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pridinol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 2263 | 511-45-5 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
antispasmodic & muscle relaxant; RN given refers to parent cpd; structure in Merck Index, 9th ed, #7539
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 6 | mg | O |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| S (Water solubility) | 0.03 mg/mL | Bocci G, Oprea TI, Benet LZ |
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Bocci G, Oprea TI, Benet LZ |
| BA (Bioavailability) | 77 % |
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| azlogd74 | LogD at pH 7.4 | 1.813 | Moderate | 0.68 | |
| caco2-efflux | Caco-2 efflux ratio (BA/AB) | 1.180 | Moderate | 0.68 | |
| caco2-intrinsic-papp | Caco-2 intrinsic apparent permeability | 30.409 | 10^-6 cm/s | Moderate | 0.68 |
| dh-clint | Dog hepatocyte intrinsic clearance | 22.387 | uL/min/10^6 cells | Moderate | 0.68 |
| dppb | Dog plasma protein binding (% unbound) | 26.190 | % | Moderate | 0.68 |
| fcs-ppb | Fetal calf serum protein binding (% unbound) | 43.930 | % | Moderate | 0.68 |
| herg | hERG pIC50 | 5.427 | pIC50 | Moderate | 0.68 |
| hh-clint | Human hepatocyte intrinsic clearance | 9.795 | uL/min/10^6 cells | Moderate | 0.68 |
| hlm-clint | Human liver microsomal intrinsic clearance | 21.429 | uL/min/mg protein | Moderate | 0.68 |
| hppb | Human plasma protein binding (% unbound) | 30.530 | % | Moderate | 0.68 |
| kinase-safety-class | ACVR2A,ACVR2B,AKT1,AKT2,AKT3,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,ITK,JAK2,JAK3,MAP3K21,MAP3K7,MAPK12,MAPK7,MAPKAPK2,MET,NTRK2,PDK2,PDK4,PDPK1,PIK3CB,PIM2,PRKDC,SIK2,SIK3,STK33,TEK,TGFBR1,TTK | 42 | |||
| kinase-selectivity-class | AKT3,AXL,BRAF,EPHB4,ERBB2,FLT3,GRK2,PDK4,SIK2,SIK3,STK33,TEK,TGFBR1 | 13 | |||
| mdck-mdr1-efflux | MDCK-MDR1 efflux ratio | 0.527 | Moderate | 0.68 | |
| mh-clint | Mouse hepatocyte intrinsic clearance | 156.675 | Moderate | 0.68 | |
| mppb | Mouse plasma protein binding (% unbound) | 44.780 | Moderate | 0.68 | |
| nih-mdck-mdr1-efflux | NIH MDCK-MDR1 efflux ratio | 1.054 | Moderate | 0.68 | |
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 | |||
| pppb | Pig plasma protein binding (% unbound) | 54.990 | % | Moderate | 0.68 |
| rh-clint | Rat hepatocyte intrinsic clearance | 276.058 | uL/min/10^6 cells | Moderate | 0.68 |
| rh-fuinc | Rat hepatocyte fraction unbound in incubation | 67.780 | % | Moderate | 0.68 |
| rppb | Rat plasma protein binding (% unbound) | 38.960 | % | Moderate | 0.68 |
| solubility-dd | Solubility at pH 7.4 in DMSO | 841.395 | uM | Moderate | 0.68 |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | M03BX03 | MUSCULO-SKELETAL SYSTEM MUSCLE RELAXANTS MUSCLE RELAXANTS, CENTRALLY ACTING AGENTS Other centrally acting agents |
| ATC | M03BX53 | MUSCULO-SKELETAL SYSTEM MUSCLE RELAXANTS MUSCLE RELAXANTS, CENTRALLY ACTING AGENTS Other centrally acting agents |
| CHEBI has role | CHEBI:48407 | antiparkinson drug |
| CHEBI has role | CHEBI:51371 | muscle relaxant |
Related Drugs by ATC class:
M03BX Other centrally acting agents 9 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 8.8 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Muscarinic acetylcholine receptor M1 | GPCR | Ki | 8.80 | PDSP | |||||
| Muscarinic acetylcholine receptor M2 | GPCR | Ki | 8.15 | PDSP | |||||
| Muscarinic acetylcholine receptor M3 | GPCR | Ki | 8.19 | PDSP | |||||
| Muscarinic acetylcholine receptor M4 | GPCR | Ki | 8.59 | PDSP | |||||
| Muscarinic acetylcholine receptor M5 | GPCR | Ki | 7.80 | PDSP |
External reference:
| ID | Source |
|---|---|
| D08418 | KEGG_DRUG |
| C0071968 | UMLSCUI |
| CHEBI:75247 | CHEBI |
| CHEMBL404215 | ChEMBL_ID |
| DB13642 | DRUGBANK_ID |
| C009185 | MESH_SUPPLEMENTAL_RECORD_UI |
| 4904 | PUBCHEM_CID |
| 1320 | INN_ID |
| 9E75Q6SUUB | UNII |
| 34479 | RXNORM |
| 006583 | NDDF |
| 39003011000001103 | SNOMEDCT_US |
| CHEMBL1528011 | ChEMBL_ID |
Pharmaceutical products:
None