cyclobenzaprine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
751 303-53-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • cyclobenzaprine
  • proheptatrien
  • proheptatriene
  • cyclobenzaprine hydrochloride
  • cyclobenzaprine HCl
structurally related to tricyclic antidepressants relieves skeletal muscle spasm of local origin without interfering with muscle function, it is ineffective in muscle spasm due to central nervous system disease
  • Molecular weight: 275.40
  • Formula: C20H21N
  • CLOGP: 5.10
  • LIPINSKI: 1
  • HAC: 1
  • HDO: 0
  • TPSA: 3.24
  • ALOGS: -4.60
  • ROTB: 3

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 200 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 1.37 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 55 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
Aug. 26, 1977 FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 1045.70 10.55 1164 66058 144756 46474084
Drug abuse 429.19 10.55 492 66730 62916 46555924
Toxicity to various agents 428.51 10.55 942 66280 210824 46408016
Respiratory arrest 236.42 10.55 267 66955 33549 46585291
Temperature regulation disorder 216.91 10.55 103 67119 3257 46615583
Food allergy 154.49 10.55 106 67116 6827 46612013
Cardio-respiratory arrest 152.00 10.55 293 66929 59576 46559264
Coeliac disease 149.06 10.55 105 67117 7056 46611784
Sedation complication 140.50 10.55 79 67143 3566 46615274
Immunodeficiency 128.40 10.55 124 67098 12982 46605858
Pain 123.00 10.55 1134 66088 475814 46143026
Bursitis 114.36 10.55 142 67080 19700 46599140
Drug hypersensitivity 109.04 10.55 661 66561 243164 46375676
Cardiac arrest 106.53 10.55 329 66893 90070 46528770
Sedation 105.75 10.55 147 67075 22763 46596077
Back pain 104.65 10.55 586 66636 209453 46409387
Constipation 101.98 10.55 508 66714 173589 46445251
Poisoning 93.53 10.55 108 67114 13886 46604954
Intentional product misuse 89.64 10.55 205 67017 46923 46571917
Hyperhidrosis 88.98 10.55 307 66915 89001 46529839
Creatinine renal clearance decreased 88.41 10.55 76 67146 6844 46611996
Fibromyalgia 75.39 10.55 164 67058 36299 46582541
Maternal exposure during pregnancy 74.89 10.55 27 67195 102522 46516318
Cognitive disorder 74.12 10.55 164 67058 36719 46582121
Exposure during pregnancy 73.27 10.55 32 67190 108180 46510660
Decorticate posture 68.57 10.55 24 67198 336 46618504
Thrombocytopenia 67.72 10.55 50 67172 126531 46492309
Hyponatraemia 65.45 10.55 32 67190 101300 46517540
Orthostatic hypotension 60.48 10.55 119 67103 24539 46594301
Fluid retention 57.52 10.55 183 67039 50863 46567977
Leukopenia 55.24 10.55 15 67207 68328 46550512
Febrile neutropenia 55.13 10.55 34 67188 94593 46524247
Upper respiratory tract infection 54.40 10.55 208 67014 63348 46555492
Anxiety 52.98 10.55 445 66777 181512 46437328
Neutropenia 52.49 10.55 78 67144 143126 46475714
Muscle spasms 50.04 10.55 326 66896 122787 46496053
Blood calcium decreased 49.00 10.55 84 67138 15589 46603251
Balance disorder 47.89 10.55 202 67020 64319 46554521
Migraine 47.22 10.55 213 67009 69813 46549027
Cardiac failure 46.19 10.55 29 67193 79919 46538921
Headache 44.76 10.55 950 66272 477402 46141438
Drug interaction 44.48 10.55 147 67075 202947 46415893
Product dose omission issue 44.29 10.55 403 66819 168117 46450723
Pancytopenia 42.45 10.55 36 67186 85022 46533818
Rash erythematous 42.27 10.55 127 67095 34223 46584617
Myocardial depression 40.39 10.55 18 67204 490 46618350
Acute kidney injury 40.01 10.55 189 67033 235666 46383174
Anaemia 38.84 10.55 213 67009 255566 46363274
Synovitis 35.49 10.55 22 67200 61053 46557787
Spinal operation 34.10 10.55 41 67181 5499 46613341
Depression 33.75 10.55 384 66838 169720 46449120
Malignant neoplasm progression 32.99 10.55 27 67195 64899 46553941
Lactic acidosis 32.45 10.55 5 67217 33904 46584936
Pulmonary malformation 32.07 10.55 10 67212 95 46618745
Injury 32.01 10.55 137 67085 43890 46574950
Hepatocellular injury 31.57 10.55 3 67219 29519 46589321
C-reactive protein increased 31.50 10.55 23 67199 58567 46560273
Hyperkalaemia 31.26 10.55 17 67205 50692 46568148
Glossodynia 30.21 10.55 13 67209 44360 46574480
Asthma 29.93 10.55 230 66992 91312 46527528
Systemic lupus erythematosus 29.67 10.55 30 67192 65150 46553690
Suspected suicide 29.52 10.55 35 67187 4626 46614214
Pyrexia 29.40 10.55 341 66881 348461 46270379
Drug ineffective 28.84 10.55 750 66472 677088 45941752
Exposure via ingestion 28.80 10.55 30 67192 3437 46615403
Fall 28.27 10.55 646 66576 328451 46290389
Renal impairment 27.73 10.55 40 67182 74332 46544508
Pleural effusion 27.72 10.55 48 67174 82904 46535936
Gamma-glutamyltransferase increased 27.53 10.55 6 67216 31734 46587106
Lower respiratory tract infection 26.65 10.55 24 67198 55065 46563775
Respiratory tract malformation 26.14 10.55 8 67214 71 46618769
Respiratory depression 26.08 10.55 54 67168 11546 46607294
Urinary incontinence 25.75 10.55 95 67127 28435 46590405
Sinusitis 25.75 10.55 293 66929 129475 46489365
Memory impairment 25.66 10.55 195 67027 77142 46541698
Intervertebral disc protrusion 25.63 10.55 76 67146 20329 46598511
Alanine aminotransferase increased 25.38 10.55 56 67166 88395 46530445
Electrocardiogram QRS complex prolonged 25.19 10.55 35 67187 5414 46613426
Depressed level of consciousness 25.13 10.55 135 67087 47434 46571406
Bone marrow failure 24.95 10.55 6 67216 29663 46589177
Electrocardiogram QT prolonged 24.07 10.55 23 67199 51302 46567538
Therapy interrupted 23.98 10.55 50 67172 10741 46608099
Dysphoria 23.53 10.55 31 67191 4558 46614282
Therapy cessation 23.47 10.55 88 67134 26541 46592299
Mobility decreased 23.11 10.55 158 67064 60436 46558404
Blood creatinine increased 23.07 10.55 47 67175 76356 46542484
Lung cyst 23.05 10.55 8 67214 109 46618731
Neck pain 22.78 10.55 147 67075 55159 46563681
Hypokalaemia 22.67 10.55 59 67163 87965 46530875
Insomnia 22.55 10.55 348 66874 164576 46454264
Gluten sensitivity 22.44 10.55 12 67210 490 46618350
Device expulsion 22.33 10.55 6 67216 27536 46591304
Off label use 22.26 10.55 399 66823 379442 46239398
Fracture pain 22.23 10.55 11 67211 381 46618459
Hand deformity 22.19 10.55 11 67211 34563 46584277
International normalised ratio increased 22 10.55 21 67201 46862 46571978
Unresponsive to stimuli 21.77 10.55 98 67124 32076 46586764
Decreased appetite 21.57 10.55 177 67045 193659 46425181
Cholestasis 21.54 10.55 6 67216 26887 46591953
Overdose 21.47 10.55 233 66989 101746 46517094
Serum sickness-like reaction 21.44 10.55 11 67211 412 46618428
Abortion spontaneous 21.13 10.55 19 67203 43627 46575213
Interstitial lung disease 21.13 10.55 28 67194 53921 46564919
Back disorder 21.08 10.55 43 67179 9098 46609742
Jaundice 20.37 10.55 8 67214 28837 46590003
Aspartate aminotransferase increased 20.07 10.55 53 67169 78647 46540193
Mucosal inflammation 20.05 10.55 16 67206 38960 46579880
Bronchitis 19.99 10.55 237 66985 105742 46513098
Peritonitis 19.94 10.55 3 67219 20711 46598129
Blood lactate dehydrogenase increased 19.66 10.55 3 67219 20497 46598343
Dry mouth 19.64 10.55 141 67081 54785 46564055
Drug screen positive 19.51 10.55 26 67196 3865 46614975
Atrial fibrillation 19.36 10.55 80 67142 103510 46515330
Post-traumatic neck syndrome 19.35 10.55 16 67206 1365 46617475
Angioedema 19.20 10.55 17 67205 39325 46579515
Sepsis 19.14 10.55 116 67106 135898 46482942
Road traffic accident 19.01 10.55 76 67146 23615 46595225
Blood bilirubin increased 18.92 10.55 13 67209 34171 46584669
Pre-existing condition improved 18.80 10.55 34 67188 6578 46612262
Meniscus injury 18.56 10.55 32 67190 5964 46612876
Liver disorder 18.29 10.55 16 67206 37230 46581610
Blood alkaline phosphatase increased 18.29 10.55 18 67204 39591 46579249
Emotional distress 18.20 10.55 90 67132 30617 46588223
Infrequent bowel movements 18.00 10.55 14 67208 1094 46617746
Drug-induced liver injury 17.97 10.55 7 67215 25361 46593479
Anti-cyclic citrullinated peptide antibody positive 17.92 10.55 3 67219 19142 46599698
Hepatic function abnormal 17.87 10.55 14 67208 34407 46584433
Agranulocytosis 17.68 10.55 5 67217 22180 46596660
Ascites 17.62 10.55 16 67206 36568 46582272
Anticholinergic syndrome 17.52 10.55 17 67205 1789 46617051
Altered state of consciousness 17.28 10.55 6 67216 23342 46595498
Intervertebral disc degeneration 17.25 10.55 50 67172 13202 46605638
Stevens-Johnson syndrome 17.22 10.55 6 67216 23291 46595549
Fatigue 17.12 10.55 1054 66168 607643 46011197
Psoriatic arthropathy 17.06 10.55 100 67122 36279 46582561
Surgery 16.80 10.55 84 67138 28701 46590139
Hypoaesthesia 16.69 10.55 252 66970 118617 46500223
General physical health deterioration 16.67 10.55 98 67124 115671 46503169
Back injury 16.48 10.55 33 67189 6888 46611952
Liver function test abnormal 16.36 10.55 26 67196 46461 46572379
Hypoglycaemia 15.93 10.55 34 67188 54315 46564525
Cardiac failure congestive 15.83 10.55 73 67149 91677 46527163
Psoriasis 15.81 10.55 178 67044 78426 46540414
Disseminated intravascular coagulation 15.68 10.55 4 67218 19001 46599839
Lymphatic system neoplasm 15.63 10.55 5 67217 52 46618788
Gastrointestinal haemorrhage 15.57 10.55 58 67164 77315 46541525
Uterine perforation 15.37 10.55 33 67189 7234 46611606
Circulatory collapse 15.26 10.55 6 67216 21618 46597222
Withdrawal syndrome 15.22 10.55 59 67163 18075 46600765
Weight increased 15.07 10.55 326 66896 164147 46454693
Lower limb fracture 14.46 10.55 45 67177 12353 46606487
Muscle strain 14.37 10.55 31 67191 6818 46612022
Platelet count decreased 14.23 10.55 85 67137 99939 46518901
Cholecystitis chronic 14.04 10.55 40 67182 10459 46608381
Spleen congestion 13.83 10.55 6 67216 153 46618687
Neutrophil count decreased 13.72 10.55 26 67196 43400 46575440
Melaena 13.55 10.55 12 67210 27760 46591080
Transaminases increased 13.54 10.55 12 67210 27749 46591091
Dyspnoea 13.50 10.55 606 66616 514942 46103898
Pericarditis 13.38 10.55 9 67213 23918 46594922
Drug eruption 13.36 10.55 7 67215 21322 46597518
Somnolence 13.32 10.55 307 66915 156214 46462626
Irritability 13.21 10.55 79 67143 28867 46589973
Epilepsy 13.18 10.55 9 67213 23729 46595111
Exposure via inhalation 13.12 10.55 4 67218 35 46618805
Disease progression 12.77 10.55 78 67144 91222 46527618
Premature delivery 12.75 10.55 8 67214 22061 46596779
Drug withdrawal syndrome 12.66 10.55 75 67147 27309 46591531
Drug intolerance 12.64 10.55 143 67079 146906 46471934
Hyperaesthesia 12.59 10.55 32 67190 7824 46611016
Joint range of motion decreased 12.52 10.55 49 67173 15075 46603765
Cardiogenic shock 12.50 10.55 4 67218 16380 46602460
Rash maculo-papular 12.49 10.55 13 67209 27861 46590979
Poor venous access 12.45 10.55 33 67189 8275 46610565
Poor quality sleep 12.29 10.55 49 67173 15204 46603636
Haematemesis 12.28 10.55 14 67208 28792 46590048
Muscle neoplasm 11.99 10.55 4 67218 48 46618792
Feeling abnormal 11.81 10.55 249 66973 124811 46494029
Copper deficiency 11.77 10.55 4 67218 51 46618789
Gallbladder neoplasm 11.77 10.55 4 67218 51 46618789
Concussion 11.72 10.55 29 67193 6974 46611866
Hostility 11.70 10.55 12 67210 1350 46617490
Antibody test positive 11.68 10.55 15 67207 2150 46616690
Multiple organ dysfunction syndrome 11.59 10.55 37 67185 51673 46567167
Cerebral infarction 11.52 10.55 10 67212 23356 46595484
Spinal cord neoplasm 11.47 10.55 6 67216 234 46618606
Bradycardia 11.29 10.55 53 67169 66245 46552595
Oedema peripheral 11.24 10.55 162 67060 159544 46459296
Upper gastrointestinal haemorrhage 11.24 10.55 5 67217 16733 46602107
Lymphopenia 11.20 10.55 4 67218 15289 46603551
Tenderness 11.11 10.55 51 67171 16830 46602010
Sleep apnoea syndrome 11.05 10.55 62 67160 22139 46596701
Neck surgery 10.96 10.55 12 67210 1455 46617385
Libido increased 10.94 10.55 9 67213 763 46618077
Treatment failure 10.80 10.55 84 67138 93003 46525837
Ischaemic hepatitis 10.73 10.55 14 67208 2039 46616801
Pregnancy 10.71 10.55 14 67208 27123 46591717
Alopecia 10.66 10.55 167 67055 162247 46456593
Body height increased 10.61 10.55 4 67218 70 46618770

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 500.38 12.41 475 21019 99017 29831967
Drug abuse 251.95 12.41 302 21192 81770 29849214
Toxicity to various agents 229.43 12.41 435 21059 176748 29754236
Respiratory arrest 143.16 12.41 138 21356 29120 29901864
Intentional product misuse 68.36 12.41 103 21391 34564 29896420
Overdose 58.27 12.41 162 21332 84175 29846809
Milk-alkali syndrome 55.39 12.41 19 21475 520 29930464
Cardio-respiratory arrest 53.04 12.41 123 21371 57183 29873801
Cardiac arrest 46.12 12.41 159 21335 92691 29838293
Back pain 45.26 12.41 169 21325 102427 29828557
Back disorder 38.56 12.41 33 21461 5961 29925023
General physical health deterioration 38.35 12.41 12 21482 99932 29831052
Product dose omission issue 36.37 12.41 146 21348 91485 29839499
Serotonin syndrome 33.61 12.41 52 21442 17839 29913145
Lymphocyte count abnormal 31.78 12.41 13 21481 585 29930399
Spinal operation 31.58 12.41 20 21474 2276 29928708
Interstitial lung disease 29.72 12.41 4 21490 60193 29870791
Pain 28.16 12.41 216 21278 172425 29758559
Back injury 28.01 12.41 22 21472 3523 29927461
Poisoning 25.59 12.41 36 21458 11346 29919638
Leukopenia 24.89 12.41 5 21489 56154 29874830
Accidental overdose 24.87 12.41 46 21448 18229 29912755
Cardiac failure 24.15 12.41 15 21479 83403 29847581
Thrombocytopenia 23.35 12.41 39 21455 137005 29793979
Drug hypersensitivity 23.15 12.41 104 21390 68415 29862569
Anaemia 22.77 12.41 75 21419 207917 29723067
Muscle spasms 21.59 12.41 98 21396 64740 29866244
Suspected suicide 21.56 12.41 18 21476 3143 29927841
C-reactive protein increased 21.19 12.41 3 21491 43470 29887514
Anion gap 21.18 12.41 10 21484 636 29930348
Spinal fracture 20.89 12.41 25 21469 6723 29924261
Exposure via ingestion 20.19 12.41 16 21478 2595 29928389
Neck pain 19.40 12.41 45 21449 20899 29910085
Death 19.18 12.41 361 21133 356922 29574062
Irritable bowel syndrome 18.47 12.41 16 21478 2936 29928048
Hyponatraemia 18.21 12.41 13 21481 67189 29863795
Vasoplegia syndrome 17.30 12.41 11 21483 1260 29929724
Pain in extremity 16.88 12.41 136 21358 110085 29820899
Arthralgia 16.38 12.41 159 21335 135632 29795352
Feeling abnormal 16.15 12.41 82 21412 56674 29874310
Ankylosing spondylitis 16.05 12.41 18 21476 4516 29926468
Malignant neoplasm progression 14.85 12.41 18 21476 72269 29858715
Insomnia 14.74 12.41 116 21378 93220 29837764
Blood creatinine increased 14.65 12.41 27 21467 91348 29839636
Anion gap abnormal 14.57 12.41 5 21489 137 29930847
Metabolic alkalosis 14.49 12.41 10 21484 1314 29929670
Product use in unapproved indication 14.46 12.41 19 21475 73674 29857310
Hepatic function abnormal 14.44 12.41 6 21488 41939 29889045
Respiratory failure 14.21 12.41 32 21462 100610 29830374
Musculoskeletal stiffness 14.07 12.41 57 21437 35824 29895160
Red blood cell sedimentation rate abnormal 13.99 12.41 11 21483 1764 29929220
Peripheral swelling 13.87 12.41 83 21411 60991 29869993
Pyrexia 13.80 12.41 140 21354 294349 29636635
Painful ejaculation 13.79 12.41 4 21490 62 29930922
Unresponsive to stimuli 13.75 12.41 46 21448 26373 29904611
Priapism 13.75 12.41 17 21477 4726 29926258
Prescribed overdose 13.51 12.41 23 21471 8538 29922446
Contusion 13.32 12.41 51 21443 31229 29899755
Respiratory depression 13.26 12.41 27 21467 11476 29919508
Ascites 12.59 12.41 5 21489 35916 29895068
Renal impairment 12.52 12.41 26 21468 84158 29846826
Gastrooesophageal reflux disease 12.45 12.41 51 21443 32204 29898780

Pharmacologic Action:

SourceCodeDescription
ATC M03BX08 MUSCULO-SKELETAL SYSTEM
MUSCLE RELAXANTS
MUSCLE RELAXANTS, CENTRALLY ACTING AGENTS
Other centrally acting agents
FDA PE N0000175730 Centrally-mediated Muscle Relaxation
FDA EPC N0000175737 Muscle Relaxant
CHEBI has role CHEBI:35469 thymoanaleptics
CHEBI has role CHEBI:35473 tranquilising drug
CHEBI has role CHEBI:51371 muscle relaxants
MeSH PA D000928 Antidepressive Agents
MeSH PA D000929 Antidepressive Agents, Tricyclic
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D009125 Muscle Relaxants, Central
MeSH PA D009465 Neuromuscular Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D011619 Psychotropic Drugs
MeSH PA D014149 Tranquilizing Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Spasticity indication 221360009
Fibromyalgia off-label use 203082005 DOID:631
Sinus tachycardia contraindication 11092001
Glaucoma contraindication 23986001 DOID:1686
Hyperthyroidism contraindication 34486009 DOID:7998
Conduction disorder of the heart contraindication 44808001
Chronic heart failure contraindication 48447003
Hepatic failure contraindication 59927004
Open-angle glaucoma contraindication 84494001 DOID:1067
Heart block contraindication 233916004
Retention of urine contraindication 267064002
Myocardial infarction in recovery phase contraindication 418044006

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.66 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
5-hydroxytryptamine receptor 2A GPCR ANTAGONIST Ki 7.54 WOMBAT-PK CHEMBL
5-hydroxytryptamine receptor 2C GPCR ANTAGONIST Ki 7.24 WOMBAT-PK
Aldehyde oxidase Enzyme IC50 5.51 WOMBAT-PK
Muscarinic acetylcholine receptor M1 GPCR IC50 6.95 WOMBAT-PK
Histamine H1 receptor GPCR Ki 8.83 WOMBAT-PK
5-hydroxytryptamine receptor 7 GPCR Ki 6.82 WOMBAT-PK
5-hydroxytryptamine receptor 6 GPCR Ki 6.84 WOMBAT-PK
5-hydroxytryptamine receptor 2B GPCR Ki 6.81 WOMBAT-PK
Sodium-dependent noradrenaline transporter Transporter Ki 7.44 WOMBAT-PK
Sodium-dependent serotonin transporter Transporter Ki 6.97 WOMBAT-PK
Multidrug resistance protein 1 Transporter IC50 4.73 WOMBAT-PK
Muscarinic acetylcholine receptor M2 GPCR Ki 7.22 PDSP
Muscarinic acetylcholine receptor M3 GPCR Ki 8.22 PDSP
Proto-oncogene tyrosine-protein kinase receptor Ret Kinase IC50 6.52 CHEMBL

External reference:

IDSource
4019699 VUID
N0000147791 NUI
D00772 KEGG_DRUG
6202-23-9 SECONDARY_CAS_RN
4017956 VANDF
4019699 VANDF
C0056732 UMLSCUI
CHEBI:3996 CHEBI
CHEMBL669 ChEMBL_ID
CHEMBL1200636 ChEMBL_ID
DB00924 DRUGBANK_ID
C004704 MESH_SUPPLEMENTAL_RECORD_UI
2895 PUBCHEM_CID
7152 IUPHAR_LIGAND_ID
791 INN_ID
69O5WQQ5TI UNII
21949 RXNORM
217 MMSL
4517 MMSL
d00963 MMSL
001678 NDDF
004680 NDDF
373779004 SNOMEDCT_US
63083007 SNOMEDCT_US
80802008 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Cyclobenzaprine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-1920 CAPSULE, EXTENDED RELEASE 15 mg ORAL NDA AUTHORIZED GENERIC 30 sections
Cyclobenzaprine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-1921 CAPSULE, EXTENDED RELEASE 30 mg ORAL NDA AUTHORIZED GENERIC 30 sections
Cyclobenzaprine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0115-1436 CAPSULE, EXTENDED RELEASE 15 mg ORAL NDA AUTHORIZED GENERIC 28 sections
Cyclobenzaprine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0115-1437 CAPSULE, EXTENDED RELEASE 30 mg ORAL NDA AUTHORIZED GENERIC 28 sections
Cyclobenzaprine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0440-1350 TABLET, FILM COATED 10 mg ORAL ANDA 20 sections
Cyclobenzaprine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0440-7350 TABLET, FILM COATED 10 mg ORAL ANDA 19 sections
Cyclobenzaprine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0591-3256 TABLET, FILM COATED 5 mg ORAL ANDA 20 sections
Cyclobenzaprine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0591-3330 TABLET, FILM COATED 7.50 mg ORAL ANDA 20 sections
Cyclobenzaprine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0591-5658 TABLET, FILM COATED 10 mg ORAL ANDA 20 sections
Cyclobenzaprine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0615-8084 TABLET, FILM COATED 10 mg ORAL ANDA 21 sections
Cyclobenzaprine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0615-8182 TABLET, FILM COATED 5 mg ORAL ANDA 14 sections
Cyclobenzaprine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0904-7809 TABLET, FILM COATED 10 mg ORAL ANDA 20 sections
Cyclobenzaprine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 10544-072 TABLET, FILM COATED 10 mg ORAL ANDA 23 sections
Cyclobenzaprine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 10544-159 TABLET 10 mg ORAL ANDA 13 sections
Cyclobenzaprine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 10544-200 TABLET, FILM COATED 5 mg ORAL ANDA 13 sections
Cyclobenzaprine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 10702-006 TABLET, FILM COATED 5 mg ORAL ANDA 13 sections
Cyclobenzaprine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 10702-007 TABLET, FILM COATED 10 mg ORAL ANDA 13 sections
Cyclobenzaprine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 12634-528 TABLET 10 mg ORAL ANDA 20 sections
Cyclobenzaprine Hydrochloride Human Prescription Drug Label 1 16571-782 TABLET, FILM COATED 5 mg ORAL ANDA 23 sections
Cyclobenzaprine Hydrochloride Human Prescription Drug Label 1 16571-783 TABLET, FILM COATED 10 mg ORAL ANDA 23 sections
CYCLOBENZAPRINE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 16590-065 TABLET 10 mg ORAL ANDA 12 sections
CYCLOBENZAPRINE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 16590-544 TABLET 5 mg ORAL ANDA 12 sections
Amrix HUMAN PRESCRIPTION DRUG LABEL 1 16590-596 CAPSULE, EXTENDED RELEASE 15 mg ORAL NDA 13 sections
FEXMID HUMAN PRESCRIPTION DRUG LABEL 1 16590-699 TABLET, FILM COATED 7.50 mg ORAL ANDA 22 sections
Amrix HUMAN PRESCRIPTION DRUG LABEL 1 16590-810 CAPSULE, EXTENDED RELEASE 30 mg ORAL NDA 13 sections
Cyclobenzaprine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 21695-036 TABLET 5 mg ORAL ANDA 13 sections
Cyclobenzaprine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 21695-037 TABLET 10 mg ORAL ANDA 13 sections
AMRIX HUMAN PRESCRIPTION DRUG LABEL 1 21695-723 CAPSULE, EXTENDED RELEASE 15 mg ORAL NDA 22 sections
Fexmid HUMAN PRESCRIPTION DRUG LABEL 1 21695-830 TABLET, FILM COATED 7.50 mg ORAL ANDA 22 sections
AMRIX HUMAN PRESCRIPTION DRUG LABEL 1 21695-953 CAPSULE, EXTENDED RELEASE 30 mg ORAL NDA 22 sections