cyclobenzaprine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	751	303-53-7

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: cyclobenzaprine proheptatrien proheptatriene cyclobenzaprine hydrochloride cyclobenzaprine HCl	structurally related to tricyclic antidepressants relieves skeletal muscle spasm of local origin without interfering with muscle function, it is ineffective in muscle spasm due to central nervous system disease Molecular weight: 275.40 Formula: C20H21N CLOGP: 4.96 LIPINSKI: 1 HAC: 1 HDO: 0 TPSA: 3.24 ALOGS: -4.60 ROTB: 3 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

cyclobenzaprine
proheptatrien
proheptatriene
cyclobenzaprine hydrochloride
cyclobenzaprine HCl

structurally related to tricyclic antidepressants relieves skeletal muscle spasm of local origin without interfering with muscle function, it is ineffective in muscle spasm due to central nervous system disease

Molecular weight: 275.40
Formula: C20H21N
CLOGP: 4.96
LIPINSKI: 1
HAC: 1
HDO: 0
TPSA: 3.24
ALOGS: -4.60
ROTB: 3

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

None

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	1	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	200 mg/mL	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	0.50 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	1.37 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability)	55 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

Date	Agency	Company	Orphan
Aug. 26, 1977	FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Completed suicide	1010.68	10.96	1107	74131	130782	50399104
Toxicity to various agents	621.51	10.96	1123	74115	211376	50318510
Drug abuse	458.42	10.96	503	74735	59343	50470543
Sedation complication	434.98	10.96	227	75011	8539	50521347
Sedation	391.85	10.96	341	74897	30269	50499617
Creatinine renal clearance decreased	378.27	10.96	230	75008	11651	50518235
Orthostatic hypotension	323.23	10.96	301	74937	29180	50500706
Cognitive disorder	292.14	10.96	344	74894	43779	50486107
Temperature regulation disorder	285.46	10.96	135	75103	4092	50525794
Blood calcium decreased	279.84	10.96	238	75000	20468	50509418
Constipation	270.07	10.96	743	74495	184965	50344921
Balance disorder	230.07	10.96	392	74846	70198	50459688
Food allergy	212.57	10.96	139	75099	7998	50521888
Depressed level of consciousness	206.80	10.96	316	74922	51637	50478249
Coeliac disease	197.22	10.96	136	75102	8549	50521337
Respiratory arrest	180.65	10.96	223	75015	29786	50500100
Immunodeficiency	171.42	10.96	156	75082	14672	50515214
Cardio-respiratory arrest	162.16	10.96	289	74949	53603	50476283
Bursitis	148.80	10.96	174	75064	21961	50507925
Pain	139.32	10.96	1391	73847	577512	49952374
Maternal exposure during pregnancy	135.80	10.96	35	75203	159743	50370143
Hyperhidrosis	123.01	10.96	351	74887	89075	50440811
Glossodynia	122.89	10.96	14	75224	115555	50414331
Mobility decreased	121.05	10.96	325	74913	79623	50450263
Drug hypersensitivity	119.96	10.96	709	74529	250301	50279585
Systemic lupus erythematosus	115.36	10.96	33	75205	140589	50389297
Hand deformity	112.09	10.96	10	75228	100189	50429697
Synovitis	109.40	10.96	25	75213	123840	50406046
Back pain	107.34	10.96	625	74613	219405	50310481
Fall	103.30	10.96	850	74388	334082	50195804
Anti-cyclic citrullinated peptide antibody positive	91.35	10.96	3	75235	70584	50459302
Fluid retention	91.31	10.96	220	75018	50429	50479457
Migraine	90.71	10.96	282	74956	74998	50454888
Pericarditis	87.61	10.96	8	75230	78681	50451205
Upper respiratory tract infection	86.10	10.96	254	74984	65644	50464242
Product dose omission issue	84.34	10.96	514	74724	183324	50346562
Cardiac arrest	79.23	10.96	289	74949	83362	50446524
Poisoning	74.19	10.96	92	75146	12337	50517549
Lower respiratory tract infection	73.29	10.96	25	75213	95176	50434710
Rash erythematous	72.29	10.96	160	75078	34692	50495194
Decorticate posture	71.87	10.96	24	75214	279	50529607
Exposure during pregnancy	71.30	10.96	46	75192	120969	50408917
Anxiety	68.84	10.96	476	74762	177130	50352756
Hyponatraemia	66.19	10.96	30	75208	96109	50433777
Asthma	64.04	10.96	283	74955	89054	50440832
Pulmonary malformation	63.79	10.96	20	75218	187	50529699
Wound	61.26	10.96	41	75197	105753	50424133
Intentional product misuse	60.90	10.96	180	75058	46554	50483332
Headache	58.51	10.96	1067	74171	505468	50024418
Fibromyalgia	56.49	10.96	171	75067	44807	50485079
Hypotension	54.87	10.96	563	74675	234906	50294980
Neutropenia	54.28	10.96	85	75153	147880	50382006
Drug ineffective	53.44	10.96	878	74360	818455	49711431
Respiratory depression	51.96	10.96	76	75162	11934	50517952
Alopecia	51.49	10.96	189	75049	244858	50285028
Therapeutic product effect decreased	51.01	10.96	77	75161	135973	50393913
Memory impairment	50.65	10.96	243	74995	79117	50450769
Psoriasis	49.00	10.96	218	75020	68782	50461104
Febrile neutropenia	48.74	10.96	44	75194	97623	50432263
Discomfort	47.09	10.96	55	75183	108325	50421561
Leukopenia	46.58	10.96	21	75217	67507	50462379
Thrombocytopenia	46.20	10.96	74	75164	127599	50402287
Pancytopenia	45.45	10.96	35	75203	83995	50445891
Cardiac failure	44.64	10.96	29	75209	76011	50453875
Joint swelling	42.94	10.96	203	75035	245083	50284803
Pyrexia	42.22	10.96	362	74876	379841	50150045
Lung cyst	42.14	10.96	14	75224	160	50529726
Myocardial depression	41.93	10.96	18	75220	432	50529454
Spinal operation	41.71	10.96	49	75189	6211	50523675
Infusion related reaction	41.66	10.96	122	75116	169435	50360451
Acute kidney injury	40.35	10.96	188	75050	227870	50302016
Anaemia	39.61	10.96	217	75021	252239	50277647
C-reactive protein increased	39.50	10.96	25	75213	66449	50463437
Suspected suicide	39.18	10.96	44	75194	5313	50524573
Post-traumatic neck syndrome	38.92	10.96	28	75210	1882	50528004
Muscle injury	38.19	10.96	5	75233	37106	50492780
Blepharospasm	38.01	10.96	33	75205	2915	50526971
Muscle spasms	37.13	10.96	316	74922	125237	50404649
Arthropathy	36.38	10.96	117	75121	157789	50372097
Contraindicated product administered	35.28	10.96	109	75129	148849	50381037
Alanine aminotransferase increased	35.09	10.96	48	75190	88311	50441575
Depression	34.97	10.96	388	74850	165035	50364851
General physical health deterioration	34.61	10.96	103	75135	142331	50387555
Treatment failure	34.56	10.96	98	75140	137539	50392347
Gastrointestinal disorder	33.00	10.96	56	75182	94400	50435486
Electrocardiogram QT prolonged	32.97	10.96	18	75220	51868	50478018
Respiratory tract malformation	32.54	10.96	10	75228	87	50529799
Libido increased	31.89	10.96	21	75217	1222	50528664
Hyperkalaemia	31.57	10.96	16	75222	48073	50481813
Therapy interrupted	31.55	10.96	83	75155	20069	50509817
Hostility	31.54	10.96	24	75214	1758	50528128
Exposure via ingestion	31.43	10.96	29	75209	2774	50527112
Renal impairment	31.17	10.96	40	75198	75621	50454265
Pre-existing condition improved	30.83	10.96	45	75193	7052	50522834
Taste disorder	30.81	10.96	49	75189	8275	50521611
Soft tissue injury	30.80	10.96	22	75216	1462	50528424
Off label use	29.90	10.96	511	74727	473915	50055971
Dysphoria	29.56	10.96	36	75202	4738	50525148
Malignant neoplasm progression	29.12	10.96	35	75203	68089	50461797
Folliculitis	28.99	10.96	11	75227	39214	50490672
International normalised ratio increased	27.37	10.96	15	75223	43137	50486749
Therapy cessation	27.30	10.96	93	75145	25918	50503968
Hypoaesthesia	27.11	10.96	299	74939	126958	50402928
Swelling	27.10	10.96	181	75057	200691	50329195
Sternal fracture	27.01	10.96	23	75215	1979	50527907
Intervertebral disc protrusion	26.99	10.96	79	75159	20314	50509572
Blood creatinine increased	26.74	10.96	45	75193	76115	50453771
Unresponsive to stimuli	26.66	10.96	103	75135	30506	50499380
Bronchitis	26.61	10.96	254	74984	103905	50425981
Surgery	26.61	10.96	102	75136	30103	50499783
Aspartate aminotransferase increased	26.55	10.96	47	75191	77951	50451935
Gamma-glutamyltransferase increased	26.09	10.96	6	75232	29617	50500269
Drug intolerance	25.91	10.96	205	75033	218899	50310987
Abdominal discomfort	25.90	10.96	220	75018	231421	50298465
Mucosal inflammation	25.40	10.96	14	75224	40128	50489758
Pleural effusion	25.17	10.96	52	75186	81402	50448484
Back disorder	24.32	10.96	47	75191	9258	50520628
Hypokalaemia	24.09	10.96	60	75178	87932	50441954
Neck pain	23.89	10.96	156	75082	56911	50472975
Rash	23.87	10.96	483	74755	436988	50092898
Urinary incontinence	23.82	10.96	94	75144	28114	50501772
Impaired healing	23.80	10.96	42	75196	69744	50460142
Lactation disorder	23.57	10.96	11	75227	323	50529563
Bone marrow failure	23.54	10.96	6	75232	27618	50502268
Concussion	23.04	10.96	41	75197	7587	50522299
Drug interaction	22.58	10.96	189	75049	199432	50330454
Fracture pain	22.50	10.96	11	75227	359	50529527
Drug-induced liver injury	22.28	10.96	7	75231	28088	50501798
Gluten sensitivity	22.12	10.96	12	75226	488	50529398
Irritability	21.84	10.96	92	75146	28334	50501552
Meniscus injury	21.83	10.96	36	75202	6266	50523620
Infection	21.77	10.96	159	75079	172795	50357091
Atrial fibrillation	21.64	10.96	78	75160	101667	50428219
Paranasal cyst	21.61	10.96	10	75228	288	50529598
Vascular malformation	21.45	10.96	10	75228	293	50529593
Device expulsion	21.43	10.96	8	75230	28814	50501072
Erythema	21.43	10.96	321	74917	146093	50383793
Decreased appetite	21.06	10.96	194	75044	200729	50329157
Stomatitis	20.70	10.96	79	75159	101265	50428621
Stress	20.69	10.96	144	75094	53649	50476237
Ascites	20.61	10.96	14	75224	35847	50494039
Jaundice	20.23	10.96	7	75231	26422	50503464
Injury	20.02	10.96	133	75105	48792	50481094
Serum sickness-like reaction	20.00	10.96	11	75227	460	50529426
Blood alkaline phosphatase increased	19.82	10.96	16	75222	37510	50492376
Hepatic function abnormal	19.82	10.96	12	75226	32669	50497217
Abortion spontaneous	19.46	10.96	20	75218	41752	50488134
Paraesthesia	19.33	10.96	268	74970	119975	50409911
Blood lactate dehydrogenase increased	19.27	10.96	3	75235	19559	50510327
Emotional distress	19.17	10.96	89	75149	28574	50501312
Dyspnoea	18.89	10.96	646	74592	546962	49982924
Poor quality sleep	18.79	10.96	61	75177	16585	50513301
Muscle twitching	18.74	10.96	58	75180	15373	50514513
Exposure via breast milk	18.74	10.96	17	75221	1591	50528295
Psoriatic arthropathy	18.74	10.96	127	75111	46905	50482981
Hyperaesthesia	18.64	10.96	39	75199	8134	50521752
Drug resistance	18.51	10.96	3	75235	18986	50510900
Feeling abnormal	18.31	10.96	275	74963	125217	50404669
Interstitial lung disease	18.13	10.96	32	75206	53144	50476742
Blister	17.82	10.96	66	75172	85352	50444534
Blood bilirubin increased	17.76	10.96	13	75225	32025	50497861
Maternal exposure during breast feeding	17.70	10.96	23	75215	3231	50526655
Liver function test abnormal	17.68	10.96	24	75214	44315	50485571
Uterine perforation	17.50	10.96	33	75205	6382	50523504
Road traffic accident	17.32	10.96	77	75161	24275	50505611
Nightmare	17.31	10.96	58	75180	16028	50513858
Infrequent bowel movements	17.28	10.96	14	75224	1124	50528762
Insomnia	17.23	10.96	360	74878	174505	50355381
Liver disorder	17.13	10.96	18	75220	37204	50492682
Withdrawal syndrome	16.82	10.96	61	75177	17529	50512357
Drug eruption	16.82	10.96	7	75231	23599	50506287
Personality disorder	16.76	10.96	26	75212	4298	50525588
Lymphatic system neoplasm	16.75	10.96	5	75233	39	50529847
Lactic acidosis	16.66	10.96	15	75223	33340	50496546
Electrocardiogram QRS complex prolonged	16.50	10.96	29	75209	5315	50524571
Mastoiditis	16.43	10.96	12	75226	826	50529060
Multiple sclerosis	16.27	10.96	67	75171	20426	50509460
Confusional state	16.01	10.96	188	75050	185740	50344146
Dry mouth	15.86	10.96	140	75098	56038	50473848
Agranulocytosis	15.84	10.96	6	75232	21415	50508471
Cardiac failure congestive	15.83	10.96	68	75170	84314	50445572
Platelet count decreased	15.53	10.96	87	75151	100639	50429247
Sepsis	15.40	10.96	125	75113	132800	50397086
Suicidal ideation	15.11	10.96	137	75101	55248	50474638
Gastrooesophageal reflux disease	15.10	10.96	177	75061	76251	50453635
Lower limb fracture	15.00	10.96	51	75187	14195	50515691
Intervertebral disc degeneration	14.90	10.96	49	75189	13412	50516474
Melaena	14.76	10.96	11	75227	26853	50503033
Oedema peripheral	14.67	10.96	157	75081	157804	50372082
Stevens-Johnson syndrome	14.63	10.96	7	75231	21745	50508141
Rib fracture	14.61	10.96	62	75176	19159	50510727
Overdose	14.33	10.96	218	75020	99509	50430377
Cholecystitis chronic	14.30	10.96	39	75199	9630	50520256
Circulatory collapse	14.14	10.96	6	75232	19994	50509892
Disseminated intravascular coagulation	14.07	10.96	4	75234	17131	50512755
Somnolence	13.96	10.96	315	74923	154670	50375216
Premature delivery	13.92	10.96	9	75229	23654	50506232
Peritonitis	13.91	10.96	3	75235	15483	50514403
Therapy non-responder	13.80	10.96	35	75203	50987	50478899
Exposure via inhalation	13.78	10.96	4	75234	28	50529858
Neutrophil count decreased	13.70	10.96	30	75208	45996	50483890
Hypoglycaemia	13.55	10.96	38	75200	53543	50476343
Multiple organ dysfunction syndrome	13.25	10.96	35	75203	50302	50479584
Haematemesis	13.22	10.96	13	75225	27712	50502174
Cholestasis	13.20	10.96	11	75227	25390	50504496
Foot fracture	13.15	10.96	62	75176	20029	50509857
Muscle strain	12.99	10.96	31	75207	7057	50522829
Neurotoxicity	12.95	10.96	3	75235	14737	50515149
Muscle neoplasm	12.89	10.96	4	75234	36	50529850
Pregnancy	12.85	10.96	15	75223	29562	50500324
Rotator cuff syndrome	12.75	10.96	42	75196	11502	50518384
Knee arthroplasty	12.74	10.96	21	75217	35825	50494061
Middle insomnia	12.71	10.96	38	75200	9883	50520003
Irritable bowel syndrome	12.63	10.96	37	75201	51404	50478482
Gallbladder neoplasm	12.61	10.96	4	75234	39	50529847
Angioedema	12.55	10.96	23	75215	37653	50492233
Product use issue	12.53	10.96	152	75086	149323	50380563
Sleep apnoea syndrome	12.38	10.96	69	75169	23799	50506087
Congenital cystic lung	12.34	10.96	4	75234	42	50529844
Hypothyroidism	12.33	10.96	90	75148	34035	50495851
Hypocalcaemia	12.31	10.96	13	75225	26803	50503083
Transaminases increased	12.21	10.96	14	75224	27810	50502076
Lymphopenia	12.19	10.96	4	75234	15617	50514269
Rash maculo-papular	12.13	10.96	13	75225	26628	50503258
Gastrointestinal haemorrhage	12.04	10.96	62	75176	73259	50456627
Bradycardia	12.03	10.96	52	75186	64374	50465512
Altered state of consciousness	12.00	10.96	9	75229	21901	50507985
Back injury	11.94	10.96	30	75208	7055	50522831
Anticholinergic syndrome	11.87	10.96	14	75224	1781	50528105
Syncope	11.87	10.96	97	75141	102905	50426981
Respiratory acidosis	11.74	10.96	27	75211	6001	50523885
Tubulointerstitial nephritis	11.69	10.96	4	75234	15207	50514679
Fatigue	11.62	10.96	1211	74027	706390	49823496
Hip arthroplasty	11.61	10.96	17	75221	30412	50499474
Multiple sclerosis relapse	11.58	10.96	106	75132	42858	50487028
Injection site mass	11.47	10.96	50	75188	15630	50514256
Liver injury	11.41	10.96	12	75226	24794	50505092
Drug withdrawal syndrome	11.38	10.96	70	75168	25011	50504875
Myalgia	11.29	10.96	253	74985	124066	50405820
Bladder discomfort	11.26	10.96	8	75230	527	50529359
Body height increased	11.24	10.96	4	75234	57	50529829
Tenderness	11.23	10.96	56	75182	18509	50511377
Copper deficiency	11.17	10.96	4	75234	58	50529828
Upper gastrointestinal haemorrhage	11.03	10.96	5	75233	16030	50513856
Rheumatoid arthritis	11.02	10.96	386	74852	202164	50327722

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Completed suicide	512.08	13.28	464	21086	89782	29463195
Drug abuse	278.34	13.28	316	21234	79567	29473410
Toxicity to various agents	216.08	13.28	423	21127	173238	29379739
Respiratory arrest	103.21	13.28	110	21440	25723	29527254
Cardio-respiratory arrest	61.02	13.28	122	21428	50479	29502498
Milk-alkali syndrome	59.64	13.28	20	21530	502	29552475
Intentional product misuse	57.56	13.28	96	21454	34565	29518412
Product dose omission issue	53.44	13.28	173	21377	96210	29456767
Back pain	46.59	13.28	172	21378	102112	29450865
General physical health deterioration	42.94	13.28	11	21539	102846	29450131
Back disorder	42.34	13.28	35	21515	5938	29547039
Spinal operation	35.35	13.28	22	21528	2392	29550585
Lymphocyte count abnormal	34.38	13.28	14	21536	613	29552364
Interstitial lung disease	31.17	13.28	3	21547	57715	29495262
Pain	29.64	13.28	220	21330	171212	29381765
Back injury	28.05	13.28	22	21528	3462	29549515
Death	27.38	13.28	374	21176	341710	29211267
Suspected suicide	27.34	13.28	23	21527	3997	29548980
Cardiac arrest	27.22	13.28	129	21421	85462	29467515
Serotonin syndrome	27.07	13.28	47	21503	17465	29535512
Thrombocytopenia	26.19	13.28	36	21514	134787	29418190
Drug hypersensitivity	25.43	13.28	108	21442	68298	29484679
Leukopenia	24.83	13.28	5	21545	55198	29497779
Ankylosing spondylitis	24.57	13.28	22	21528	4154	29548823
Overdose	23.73	13.28	118	21432	79701	29473276
Spinal fracture	23.07	13.28	26	21524	6460	29546517
Asthma-chronic obstructive pulmonary disease overlap syndrome	22.67	13.28	11	21539	732	29552245
C-reactive protein increased	22.15	13.28	3	21547	44260	29508717
Anaemia	21.37	13.28	75	21475	200876	29352101
Exposure via ingestion	21.31	13.28	15	21535	2003	29550974
Poisoning	21.20	13.28	31	21519	9962	29543015
Product use in unapproved indication	20.30	13.28	20	21530	86855	29466122
Anion gap	19.80	13.28	10	21540	726	29552251
Arthralgia	19.65	13.28	171	21379	139446	29413531
Peripheral swelling	18.77	13.28	94	21456	63645	29489332
Bronchial hyperreactivity	18.56	13.28	12	21538	1394	29551583
Cardiac failure	17.68	13.28	19	21531	79268	29473709
Metabolic alkalosis	17.43	13.28	11	21539	1225	29551752
Feeling abnormal	17.25	13.28	82	21468	54363	29498614
Blood creatinine increased	17.25	13.28	22	21528	85080	29467897
Muscle spasms	17.11	13.28	93	21457	64989	29487988
Hyponatraemia	16.47	13.28	15	21535	67618	29485359
Accidental poisoning	16.24	13.28	8	21542	550	29552427
Adverse drug reaction	15.97	13.28	46	21504	23974	29529003
Respiratory failure	15.94	13.28	29	21521	97102	29455875
Intervertebral disc protrusion	15.71	13.28	25	21525	8645	29544332
Unresponsive to stimuli	15.64	13.28	47	21503	25079	29527898
Vasoplegia syndrome	15.44	13.28	11	21539	1497	29551480
Psoriasis	15.31	13.28	55	21495	32172	29520805
Neck pain	15.17	13.28	42	21508	21405	29531572
Hepatic function abnormal	14.90	13.28	5	21545	39254	29513723
Pain in extremity	14.87	13.28	134	21416	110299	29442678
Insomnia	14.78	13.28	113	21437	88648	29464329
Irritable bowel syndrome	14.59	13.28	14	21536	2887	29550090
Anion gap abnormal	14.32	13.28	5	21545	142	29552835
Painful ejaculation	13.73	13.28	4	21546	62	29552915
Melaena	13.65	13.28	3	21547	31173	29521804
Ascites	13.32	13.28	5	21545	36614	29516363

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Completed suicide	1482.99	10.79	1586	77212	222828	64197106
Toxicity to various agents	791.81	10.79	1512	77286	362001	64057933
Drug abuse	664.31	10.79	813	77985	131561	64288373
Sedation complication	485.20	10.79	242	78556	10112	64409822
Creatinine renal clearance decreased	420.51	10.79	246	78552	14175	64405759
Sedation	399.22	10.79	361	78437	41101	64378833
Cognitive disorder	313.23	10.79	361	78437	54726	64365208
Blood calcium decreased	309.99	10.79	254	78544	25300	64394634
Temperature regulation disorder	304.82	10.79	133	78665	4078	64415856
Orthostatic hypotension	292.53	10.79	322	78476	46416	64373518
Constipation	270.07	10.79	750	78048	228587	64191347
Balance disorder	258.61	10.79	408	78390	83518	64336416
Pain	253.41	10.79	1337	77461	552174	63867760
Respiratory arrest	251.74	10.79	317	78481	52668	64367266
Coeliac disease	233.53	10.79	133	78665	7279	64412655
Food allergy	231.68	10.79	135	78663	7716	64412218
Cardio-respiratory arrest	212.56	10.79	409	78389	97984	64321950
Depressed level of consciousness	209.38	10.79	365	78433	81071	64338863
Immunodeficiency	172.29	10.79	149	78649	15975	64403959
Bursitis	172.11	10.79	169	78629	21316	64398618
Mobility decreased	161.61	10.79	337	78461	85503	64334431
Drug hypersensitivity	132.90	10.79	609	78189	237206	64182728
Back pain	131.28	10.79	629	78169	249542	64170392
Intentional product misuse	119.12	10.79	269	78529	72026	64347908
Migraine	109.78	10.79	239	78559	62438	64357496
Fall	97.53	10.79	854	77944	415972	64003962
Fluid retention	97.31	10.79	221	78577	59385	64360549
Cardiac arrest	94.63	10.79	406	78392	153658	64266276
Poisoning	88.50	10.79	121	78677	21758	64398176
Product dose omission issue	88.24	10.79	470	78328	194277	64225657
Upper respiratory tract infection	85.38	10.79	238	78560	72547	64347387
Hyperhidrosis	82.79	10.79	337	78461	124583	64295351
Thrombocytopenia	82.52	10.79	91	78707	223710	64196224
Acute kidney injury	80.18	10.79	281	78517	448959	63970975
Hyponatraemia	79.42	10.79	41	78757	148298	64271636
Decorticate posture	75.43	10.79	24	78774	293	64419641
Neutropenia	75.29	10.79	110	78688	239514	64180420
Anaemia	70.85	10.79	232	78566	378448	64041486
Asthma	68.81	10.79	264	78534	94961	64324973
Headache	67.71	10.79	963	77835	528504	63891430
Pyrexia	67.16	10.79	404	78394	558240	63861694
Fibromyalgia	66.87	10.79	140	78658	35591	64384343
Febrile neutropenia	66.24	10.79	79	78719	187578	64232356
General physical health deterioration	66.03	10.79	92	78706	204333	64215601
Cardiac failure	65.94	10.79	40	78758	132333	64287601
Rash erythematous	63.02	10.79	165	78633	48468	64371466
Leukopenia	60.40	10.79	24	78774	101218	64318716
Synovitis	59.92	10.79	23	78775	99067	64320867
Spinal operation	56.25	10.79	52	78746	6081	64413853
Suspected suicide	53.03	10.79	59	78739	8595	64411339
Hand deformity	52.96	10.79	7	78791	62764	64357170
Drug interaction	52.25	10.79	246	78552	361837	64058097
Anxiety	51.35	10.79	423	78375	202226	64217708
C-reactive protein increased	51.13	10.79	26	78772	94883	64325051
Pericarditis	50.36	10.79	8	78790	62508	64357426
Renal impairment	49.62	10.79	55	78743	134962	64284972
Memory impairment	48.91	10.79	221	78577	85461	64334473
Blood creatinine increased	48.07	10.79	57	78741	135725	64284209
Pancytopenia	47.77	10.79	63	78735	143246	64276688
Exposure via ingestion	47.76	10.79	43	78755	4859	64415075
Pulmonary malformation	47.07	10.79	14	78784	134	64419800
Interstitial lung disease	46.65	10.79	31	78767	97701	64322233
Lower respiratory tract infection	46.54	10.79	29	78769	94585	64325349
Psoriasis	46.34	10.79	192	78606	71511	64348423
Back disorder	46.19	10.79	59	78739	9931	64410003
Rheumatoid arthritis	46.03	10.79	351	78447	163943	64255991
Malignant neoplasm progression	46.02	10.79	42	78756	112829	64307105
Hyperkalaemia	45.73	10.79	34	78764	101095	64318839
Maternal exposure during pregnancy	44.98	10.79	31	78767	95853	64324081
Multiple organ dysfunction syndrome	44.70	10.79	35	78763	101378	64318556
Hepatocellular injury	43.54	10.79	3	78795	45232	64374702
Myocardial depression	43.41	10.79	18	78780	485	64419449
Off label use	42.63	10.79	532	78266	632274	63787660
Death	42.06	10.79	825	77973	481880	63938054
Post-traumatic neck syndrome	41.55	10.79	27	78771	1875	64418059
Hepatic function abnormal	40.45	10.79	14	78784	64299	64355635
Gamma-glutamyltransferase increased	39.54	10.79	6	78792	48504	64371430
Alanine aminotransferase increased	38.76	10.79	69	78729	138962	64280972
Respiratory depression	38.33	10.79	87	78711	23356	64396578
Systemic lupus erythematosus	37.88	10.79	24	78774	77588	64342346
Neck pain	36.84	10.79	161	78637	61372	64358562
Bone marrow failure	36.73	10.79	7	78791	47945	64371989
International normalised ratio increased	36.59	10.79	26	78772	79141	64340793
Hypoglycaemia	35.99	10.79	34	78764	89858	64330076
Glossodynia	35.94	10.79	17	78781	64679	64355255
Unresponsive to stimuli	35.80	10.79	139	78659	50254	64369680
Blepharospasm	35.67	10.79	31	78767	3344	64416590
Electrocardiogram QT prolonged	35.55	10.79	27	78771	79421	64340513
Ascites	34.89	10.79	16	78782	61985	64357949
Melaena	34.83	10.79	11	78787	53537	64366397
Therapy cessation	33.99	10.79	102	78696	32387	64387547
Platelet count decreased	33.95	10.79	99	78699	167612	64252322
Milk-alkali syndrome	33.84	10.79	20	78778	1173	64418761
Soft tissue injury	33.48	10.79	22	78776	1557	64418377
Lung cyst	33.07	10.79	11	78787	156	64419778
Overdose	32.65	10.79	318	78480	159248	64260686
Decreased appetite	32.35	10.79	206	78592	281083	64138851
Concussion	32.25	10.79	44	78754	7894	64412040
Hypoaesthesia	31.86	10.79	284	78514	138824	64281110
Hostility	31.17	10.79	24	78774	2183	64417751
Libido increased	30.98	10.79	22	78776	1768	64418166
Pleural effusion	30.81	10.79	68	78730	126491	64293443
Sternal fracture	30.79	10.79	24	78774	2223	64417711
Taste disorder	30.60	10.79	47	78751	9386	64410548
Hyperaesthesia	29.86	10.79	48	78750	9966	64409968
Sepsis	29.49	10.79	163	78635	230178	64189756
Surgery	28.97	10.79	88	78710	28125	64391809
Drug-induced liver injury	28.89	10.79	11	78787	47632	64372302
Lactic acidosis	28.60	10.79	20	78778	61390	64358544
Depression	28.57	10.79	346	78452	182945	64236989
Back injury	28.54	10.79	41	78757	7716	64412218
Mucosal inflammation	28.34	10.79	21	78777	62563	64357371
Injury	27.99	10.79	139	78659	55853	64364081
Aspartate aminotransferase increased	27.83	10.79	66	78732	119722	64300212
Cholestasis	27.82	10.79	10	78788	44862	64375072
Lactation disorder	27.81	10.79	10	78788	181	64419753
Intervertebral disc protrusion	27.69	10.79	70	78728	20121	64399813
Serotonin syndrome	27.62	10.79	108	78690	39174	64380760
Fatigue	27.39	10.79	1146	77652	747584	63672350
Gastrointestinal disorder	27.34	10.79	42	78756	89667	64330267
Hypotension	27.26	10.79	633	78165	380341	64039593
Blood lactate dehydrogenase increased	27.17	10.79	4	78794	33074	64386860
Atrial fibrillation	26.58	10.79	113	78685	170976	64248958
Road traffic accident	26.22	10.79	90	78708	30655	64389279
Drug eruption	26.18	10.79	6	78792	36130	64383804
Exposure during pregnancy	26.02	10.79	34	78764	77641	64342293
Meniscus injury	25.92	10.79	34	78764	5873	64414061
Electrocardiogram QRS complex prolonged	25.79	10.79	43	78755	9201	64410733
Bronchitis	25.40	10.79	223	78575	108520	64311414
Cytomegalovirus infection	25.36	10.79	7	78791	37192	64382742
Gluten sensitivity	25.12	10.79	11	78787	340	64419594
Drug resistance	25.09	10.79	6	78792	35096	64384838
Jaundice	25.08	10.79	14	78784	48498	64371436
Muscle spasms	25.02	10.79	273	78525	140750	64279184
Uterine perforation	24.77	10.79	33	78765	5787	64414147
Fracture pain	24.74	10.79	11	78787	353	64419581
Hypokalaemia	24.64	10.79	72	78726	121831	64298103
Cardiogenic shock	24.28	10.79	5	78793	32422	64387512
Disseminated intravascular coagulation	24.19	10.79	5	78793	32343	64387591
Blood alkaline phosphatase increased	24.07	10.79	20	78778	56259	64363675
Therapy interrupted	23.95	10.79	66	78732	19970	64399964
Rash maculo-papular	23.70	10.79	14	78784	47012	64372922
Emotional distress	23.67	10.79	97	78701	35941	64383993
Circulatory collapse	23.66	10.79	6	78792	33726	64386208
Pneumocystis jirovecii pneumonia	23.50	10.79	3	78795	27631	64392303
Vascular malformation	23.37	10.79	10	78788	292	64419642
Intervertebral disc degeneration	22.92	10.79	50	78748	13070	64406864
Agranulocytosis	22.89	10.79	9	78789	38220	64381714
Blood bilirubin increased	22.77	10.79	22	78776	57531	64362403
Tubulointerstitial nephritis	22.66	10.79	5	78793	30904	64389030
Altered state of consciousness	22.57	10.79	9	78789	37893	64382041
Respiratory failure	22.33	10.79	111	78687	161072	64258862
Maternal exposure during breast feeding	22.28	10.79	19	78779	1997	64417937
Paranasal cyst	22.12	10.79	10	78788	334	64419600
Personality disorder	22.06	10.79	28	78770	4683	64415251
Feeling abnormal	22.05	10.79	255	78543	133347	64286587
Lower limb fracture	21.84	10.79	50	78748	13495	64406439
Pre-existing condition improved	21.82	10.79	28	78770	4734	64415200
Gastrooesophageal reflux disease	21.81	10.79	175	78623	82968	64336966
Dyspnoea	21.73	10.79	691	78107	717983	63701951
Hypocalcaemia	21.65	10.79	12	78786	41741	64378193
Syncope	21.02	10.79	110	78688	157525	64262409
Hepatic failure	20.97	10.79	22	78776	55372	64364562
Oedema peripheral	20.74	10.79	161	78637	210156	64209778
Painful ejaculation	20.60	10.79	4	78794	3	64419931
Erythema	20.58	10.79	332	78466	186738	64233196
Serum sickness-like reaction	20.42	10.79	11	78787	539	64419395
Wound	20.38	10.79	39	78759	76438	64343496
Withdrawal syndrome	20.24	10.79	69	78729	23423	64396511
Dry mouth	19.74	10.79	134	78664	60284	64359650
Stress	19.63	10.79	134	78664	60400	64359534
Rhinorrhoea	19.59	10.79	133	78665	59836	64360098
Multiple sclerosis	19.37	10.79	59	78739	18882	64401052
Neutrophil count decreased	19.18	10.79	41	78757	77155	64342779
Exposure via breast milk	19.16	10.79	12	78786	782	64419152
Application site burn	19.13	10.79	12	78786	784	64419150
Bradycardia	19.03	10.79	77	78721	118142	64301792
Dysphoria	18.86	10.79	25	78773	4363	64415571
Pneumonia aspiration	18.79	10.79	27	78771	59244	64360690
Prescribed overdose	18.65	10.79	61	78737	20270	64399664
Infusion related reaction	18.60	10.79	121	78677	164346	64255588
Infection	18.48	10.79	141	78657	184739	64235195
Haemoglobin decreased	18.46	10.79	151	78647	194912	64225022
Poor quality sleep	18.42	10.79	58	78740	18893	64401041
Septic shock	18.04	10.79	67	78731	105370	64314564
Liver function test abnormal	17.92	10.79	28	78770	59373	64360561
Respiratory tract malformation	17.72	10.79	5	78793	39	64419895
Acute hepatic failure	17.64	10.79	5	78793	26107	64393827
Haematemesis	17.42	10.79	19	78779	46980	64372954
Lymphatic system neoplasm	17.29	10.79	5	78793	43	64419891
Lymphopenia	17.17	10.79	5	78793	25652	64394282
Neurotoxicity	17.17	10.79	6	78792	27398	64392536
Cerebral infarction	17.05	10.79	15	78783	41029	64378905
Cardiac failure congestive	16.92	10.79	92	78706	130488	64289446
Insomnia	16.77	10.79	337	78461	197499	64222435
Gastrointestinal haemorrhage	16.72	10.79	94	78704	132218	64287716
Stomatitis	16.64	10.79	73	78725	109532	64310402
Transaminases increased	16.55	10.79	18	78780	44576	64375358
Paraesthesia	16.42	10.79	243	78555	134279	64285655
Muscle injury	16.20	10.79	6	78792	26431	64393503
Stevens-Johnson syndrome	16.15	10.79	11	78787	34238	64385696
Renal failure	16.13	10.79	143	78655	181545	64238389
Hepatotoxicity	16.13	10.79	15	78783	39947	64379987
Allodynia	16.07	10.79	13	78785	1270	64418664
Proteinuria	15.84	10.79	7	78791	27716	64392218
Cholecystitis chronic	15.78	10.79	35	78763	9252	64410682
Upper gastrointestinal haemorrhage	15.71	10.79	12	78786	35208	64384726
Muscle twitching	15.67	10.79	55	78743	18943	64400991
Cerebral haemorrhage	15.49	10.79	24	78774	51066	64368868
Urinary incontinence	15.49	10.79	86	78712	36065	64383869
Blood creatine phosphokinase increased	15.48	10.79	30	78768	58528	64361406
Pneumonia	15.47	10.79	544	78254	559032	63860902
Asthma-chronic obstructive pulmonary disease overlap syndrome	15.38	10.79	12	78786	1113	64418821
Liver disorder	15.29	10.79	26	78772	53325	64366609
Disease progression	15.14	10.79	106	78692	141574	64278360
Ankylosing spondylitis	15.09	10.79	32	78766	8202	64411732
Polyneuropathy	15.03	10.79	3	78795	19891	64400043
Nightmare	14.98	10.79	58	78740	20935	64398999
Osteonecrosis of jaw	14.87	10.79	16	78782	39809	64380125
Hyperglycaemia	14.63	10.79	33	78765	60935	64358999
Rotator cuff syndrome	14.59	10.79	40	78758	12067	64407867
Therapeutic product effect decreased	14.54	10.79	82	78716	115269	64304665
Sciatica	14.47	10.79	56	78742	20208	64399726
Myelodysplastic syndrome	14.20	10.79	8	78790	27571	64392363
Bronchopulmonary aspergillosis	14.17	10.79	3	78795	19082	64400852
Psoriatic arthropathy	14.14	10.79	96	78702	43185	64376749
Ischaemic stroke	14.13	10.79	9	78789	29026	64390908
Muscle strain	14.05	10.79	31	78767	8163	64411771
Rib fracture	13.70	10.79	62	78736	23976	64395958
Injection site mass	13.39	10.79	49	78749	17221	64402713
Peritonitis	13.26	10.79	7	78791	25016	64394918
Pneumonitis	13.14	10.79	26	78772	50339	64369595
Irritability	12.91	10.79	83	78715	36663	64383271
Gait disturbance	12.89	10.79	288	78510	171867	64248067
Angioedema	12.86	10.79	36	78762	61785	64358149
Confusional state	12.86	10.79	233	78565	260911	64159023
Sinusitis	12.84	10.79	250	78548	145678	64274256
Mastoiditis	12.77	10.79	12	78786	1433	64418501
Extrapyramidal disorder	12.74	10.79	4	78794	19548	64400386
Muscle neoplasm	12.34	10.79	4	78794	52	64419882
Sinus headache	12.32	10.79	20	78778	4187	64415747
Pulmonary fibrosis	12.31	10.79	11	78787	29867	64390067
Pain in extremity	12.19	10.79	469	78329	302616	64117318
Rash	12.15	10.79	448	78350	458101	63961833
Anuria	12.15	10.79	4	78794	18960	64400974
Pelvic pain	12.12	10.79	35	78763	10875	64409059
Myocarditis	12.01	10.79	3	78795	17040	64402894
Intentional overdose	11.98	10.79	165	78633	89779	64330155
Injection site pain	11.97	10.79	197	78601	111211	64308723
Drug ineffective	11.93	10.79	875	77923	839372	63580562
Therapy non-responder	11.85	10.79	41	78757	65858	64354076
Oropharyngeal pain	11.83	10.79	163	78635	88704	64331230
Poor sucking reflex	11.76	10.79	4	78794	61	64419873
Thrombosis	11.72	10.79	135	78663	70507	64349427
Appetite disorder	11.72	10.79	25	78773	6436	64413498
Treatment failure	11.71	10.79	89	78709	116727	64303207
Major depression	11.67	10.79	28	78770	7788	64412146
Hypophagia	11.62	10.79	19	78779	39568	64380366
Myocardial ischaemia	11.60	10.79	7	78791	23244	64396690
Throat irritation	11.56	10.79	74	78724	32637	64387297
Lung disorder	11.44	10.79	37	78761	60663	64359271
Blood urea increased	11.34	10.79	23	78775	44130	64375804
Catheter site bruise	11.25	10.79	6	78792	288	64419646
Foot fracture	11.24	10.79	48	78750	18109	64401825
Gallbladder neoplasm	11.09	10.79	4	78794	73	64419861
Suicidal ideation	10.96	10.79	127	78671	66415	64353519
Total lung capacity	10.91	10.79	3	78795	21	64419913
Hypoalbuminaemia	10.85	10.79	4	78794	17670	64402264
Basal cell carcinoma	10.85	10.79	13	78785	30825	64389109

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	M03BX08	MUSCULO-SKELETAL SYSTEM MUSCLE RELAXANTS MUSCLE RELAXANTS, CENTRALLY ACTING AGENTS Other centrally acting agents
MeSH PA	D000928	Antidepressive Agents
MeSH PA	D000929	Antidepressive Agents, Tricyclic
MeSH PA	D002491	Central Nervous System Agents
MeSH PA	D002492	Central Nervous System Depressants
MeSH PA	D009125	Muscle Relaxants, Central
MeSH PA	D009465	Neuromuscular Agents
MeSH PA	D018373	Peripheral Nervous System Agents
MeSH PA	D011619	Psychotropic Drugs
MeSH PA	D014149	Tranquilizing Agents
CHEBI has role	CHEBI:35469	antidepressants
CHEBI has role	CHEBI:35473	tranquilizing drugs
CHEBI has role	CHEBI:51371	muscle relaxants
FDA PE	N0000175730	Centrally-mediated Muscle Relaxation
FDA EPC	N0000175737	Muscle Relaxant

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Spasticity	indication	221360009
Fibromyalgia	off-label use	203082005	DOID:631
Sinus tachycardia	contraindication	11092001
Glaucoma	contraindication	23986001	DOID:1686
Hyperthyroidism	contraindication	34486009	DOID:7998
Conduction disorder of the heart	contraindication	44808001
Chronic heart failure	contraindication	48447003
Hepatic failure	contraindication	59927004
Open-angle glaucoma	contraindication	84494001	DOID:1067
Heart block	contraindication	233916004
Retention of urine	contraindication	267064002
Myocardial infarction in recovery phase	contraindication	418044006

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	8.66	Basic

Orange Book patent data (new drug applications)

Formulation strength	Trade name	Applicant	Application number	Approval date	Type	Dose form	Route	Patent number	Patent expiration date	Patent use
15MG	AMRIX	TEVA PHARMS INTL	N021777	Feb. 1, 2007	RX	CAPSULE, EXTENDED RELEASE	ORAL	7544372	Nov. 14, 2023	RELIEF OF MUSCLE SPASM
15MG	AMRIX	TEVA PHARMS INTL	N021777	Feb. 1, 2007	RX	CAPSULE, EXTENDED RELEASE	ORAL	7829121	Nov. 14, 2023	RELIEF OF MUSCLE SPASM
15MG	AMRIX	TEVA PHARMS INTL	N021777	Feb. 1, 2007	RX	CAPSULE, EXTENDED RELEASE	ORAL	8877245	Nov. 14, 2023	RELIEF OF MUSCLE SPASM
15MG	AMRIX	TEVA PHARMS INTL	N021777	Feb. 1, 2007	RX	CAPSULE, EXTENDED RELEASE	ORAL	9375410	Nov. 14, 2023	RELIEF OF MUSCLE SPASM
15MG	AMRIX	TEVA PHARMS INTL	N021777	Feb. 1, 2007	RX	CAPSULE, EXTENDED RELEASE	ORAL	9399025	Nov. 14, 2023	RELIEF OF MUSCLE SPASM
30MG	AMRIX	TEVA PHARMS INTL	N021777	Feb. 1, 2007	RX	CAPSULE, EXTENDED RELEASE	ORAL	7544372	Nov. 14, 2023	RELIEF OF MUSCLE SPASM
30MG	AMRIX	TEVA PHARMS INTL	N021777	Feb. 1, 2007	RX	CAPSULE, EXTENDED RELEASE	ORAL	7829121	Nov. 14, 2023	RELIEF OF MUSCLE SPASM
30MG	AMRIX	TEVA PHARMS INTL	N021777	Feb. 1, 2007	RX	CAPSULE, EXTENDED RELEASE	ORAL	8877245	Nov. 14, 2023	RELIEF OF MUSCLE SPASM
30MG	AMRIX	TEVA PHARMS INTL	N021777	Feb. 1, 2007	RX	CAPSULE, EXTENDED RELEASE	ORAL	9375410	Nov. 14, 2023	RELIEF OF MUSCLE SPASM
30MG	AMRIX	TEVA PHARMS INTL	N021777	Feb. 1, 2007	RX	CAPSULE, EXTENDED RELEASE	ORAL	9399025	Nov. 14, 2023	RELIEF OF MUSCLE SPASM

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source	MoA source
5-hydroxytryptamine receptor 2A	GPCR	P28223	5HT2A_HUMAN	ANTAGONIST	Ki	7.54	WOMBAT-PK	CHEMBL
Sodium-dependent serotonin transporter	Transporter	P31645	SC6A4_HUMAN		Ki	6.97	WOMBAT-PK
Sodium-dependent noradrenaline transporter	Transporter	P23975	SC6A2_HUMAN		Ki	7.44	WOMBAT-PK
5-hydroxytryptamine receptor 2B	GPCR	P41595	5HT2B_HUMAN		Ki	6.81	WOMBAT-PK
5-hydroxytryptamine receptor 2C	GPCR	P28335	5HT2C_HUMAN	ANTAGONIST	Ki	7.24	WOMBAT-PK
5-hydroxytryptamine receptor 6	GPCR	P50406	5HT6R_HUMAN		Ki	6.84	WOMBAT-PK
5-hydroxytryptamine receptor 7	GPCR	P34969	5HT7R_HUMAN		Ki	6.82	WOMBAT-PK
Histamine H1 receptor	GPCR	P35367	HRH1_HUMAN		Ki	8.83	WOMBAT-PK
Muscarinic acetylcholine receptor M1	GPCR	P11229	ACM1_HUMAN		IC50	6.95	WOMBAT-PK
Muscarinic acetylcholine receptor M2	GPCR	P08172	ACM2_HUMAN		Ki	7.22	PDSP
Muscarinic acetylcholine receptor M3	GPCR	P20309	ACM3_HUMAN		Ki	8.22	PDSP
Aldehyde oxidase	Enzyme	Q06278	AOXA_HUMAN		IC50	5.51	WOMBAT-PK
Multidrug resistance protein 1	Transporter	P08183	MDR1_HUMAN		IC50	4.73	WOMBAT-PK
Proto-oncogene tyrosine-protein kinase receptor Ret	Kinase	P07949	RET_HUMAN		IC50	6.52	CHEMBL

External reference:

ID	Source
4019699	VUID
N0000147791	NUI
D00772	KEGG_DRUG
6202-23-9	SECONDARY_CAS_RN
21949	RXNORM
4017956	VANDF
4019699	VANDF
C0056732	UMLSCUI
CHEBI:3996	CHEBI
CHEMBL669	ChEMBL_ID
DB00924	DRUGBANK_ID
CHEMBL1200636	ChEMBL_ID
C004704	MESH_SUPPLEMENTAL_RECORD_UI
2895	PUBCHEM_CID
7152	IUPHAR_LIGAND_ID
791	INN_ID
69O5WQQ5TI	UNII
217	MMSL
4517	MMSL
d00963	MMSL
001678	NDDF
004680	NDDF
373779004	SNOMEDCT_US
63083007	SNOMEDCT_US
80802008	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Cyclobenzaprine Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0093-1920	CAPSULE, EXTENDED RELEASE	15 mg	ORAL	NDA authorized generic	30 sections
Cyclobenzaprine Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0093-1921	CAPSULE, EXTENDED RELEASE	30 mg	ORAL	NDA authorized generic	30 sections
Cyclobenzaprine Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0093-3420	TABLET, FILM COATED	5 mg	ORAL	ANDA	20 sections
Cyclobenzaprine Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0093-3421	TABLET, FILM COATED	7.50 mg	ORAL	ANDA	20 sections
Cyclobenzaprine Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0093-3422	TABLET, FILM COATED	10 mg	ORAL	ANDA	20 sections
Cyclobenzaprine Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0115-1436	CAPSULE, EXTENDED RELEASE	15 mg	ORAL	NDA AUTHORIZED GENERIC	28 sections
Cyclobenzaprine Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0115-1437	CAPSULE, EXTENDED RELEASE	30 mg	ORAL	NDA AUTHORIZED GENERIC	28 sections
Cyclobenzaprine Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0440-1350	TABLET, FILM COATED	10 mg	ORAL	ANDA	20 sections
Cyclobenzaprine Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0440-7350	TABLET, FILM COATED	10 mg	ORAL	ANDA	19 sections
Cyclobenzaprine Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0591-3256	TABLET, FILM COATED	5 mg	ORAL	ANDA	20 sections
Cyclobenzaprine Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0591-3330	TABLET, FILM COATED	7.50 mg	ORAL	ANDA	20 sections
Cyclobenzaprine Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0591-5658	TABLET, FILM COATED	10 mg	ORAL	ANDA	20 sections
Cyclobenzaprine Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8084	TABLET, FILM COATED	10 mg	ORAL	ANDA	21 sections
Cyclobenzaprine Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8182	TABLET, FILM COATED	5 mg	ORAL	ANDA	14 sections
Cyclobenzaprine Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0904-7809	TABLET, FILM COATED	10 mg	ORAL	ANDA	20 sections
Cyclobenzaprine Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	10544-072	TABLET, FILM COATED	10 mg	ORAL	ANDA	23 sections
Cyclobenzaprine Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	10544-159	TABLET	10 mg	ORAL	ANDA	13 sections
Cyclobenzaprine Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	10544-200	TABLET, FILM COATED	5 mg	ORAL	ANDA	13 sections
Cyclobenzaprine Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	10702-006	TABLET, FILM COATED	5 mg	ORAL	ANDA	13 sections
Cyclobenzaprine Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	10702-007	TABLET, FILM COATED	10 mg	ORAL	ANDA	13 sections
Cyclobenzaprine Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	12634-528	TABLET	10 mg	ORAL	ANDA	20 sections
Cyclobenzaprine Hydrochloride	Human Prescription Drug Label	1	16571-782	TABLET, FILM COATED	5 mg	ORAL	ANDA	23 sections
Cyclobenzaprine Hydrochloride	Human Prescription Drug Label	1	16571-783	TABLET, FILM COATED	10 mg	ORAL	ANDA	23 sections
CYCLOBENZAPRINE HYDROCHLORIDE	HUMAN PRESCRIPTION DRUG LABEL	1	16590-065	TABLET	10 mg	ORAL	ANDA	12 sections
CYCLOBENZAPRINE HYDROCHLORIDE	HUMAN PRESCRIPTION DRUG LABEL	1	16590-544	TABLET	5 mg	ORAL	ANDA	12 sections
Amrix	HUMAN PRESCRIPTION DRUG LABEL	1	16590-596	CAPSULE, EXTENDED RELEASE	15 mg	ORAL	NDA	13 sections
FEXMID	HUMAN PRESCRIPTION DRUG LABEL	1	16590-699	TABLET, FILM COATED	7.50 mg	ORAL	ANDA	22 sections
Amrix	HUMAN PRESCRIPTION DRUG LABEL	1	16590-810	CAPSULE, EXTENDED RELEASE	30 mg	ORAL	NDA	13 sections
Cyclobenzaprine Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	21695-036	TABLET	5 mg	ORAL	ANDA	13 sections
Cyclobenzaprine Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	21695-037	TABLET	10 mg	ORAL	ANDA	13 sections