Stem definition | Drug id | CAS RN |
---|---|---|
vinca alkaloids | 2828 | 42971-09-5 |
Dose | Unit | Route |
---|---|---|
15 | mg | O |
Property | Value | Reference |
---|---|---|
BA (Bioavailability) | 6.70 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 2.08 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 6.10 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.02 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 4.83 hours | Lombardo F, Berellini G, Obach RS |
None
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Psychomotor retardation | 52.53 | 45.83 | 11 | 489 | 3222 | 46682340 |
Bradykinesia | 50.29 | 45.83 | 11 | 489 | 3955 | 46681607 |
Flat affect | 49.35 | 45.83 | 9 | 491 | 1289 | 46684273 |
Tension | 47.90 | 45.83 | 10 | 490 | 2882 | 46682680 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|
Source | Code | Description |
---|---|---|
ATC | N06BX18 | NERVOUS SYSTEM PSYCHOANALEPTICS PSYCHOSTIMULANTS, AGENTS USED FOR ADHD AND NOOTROPICS Other psychostimulants and nootropics |
MeSH PA | D002317 | Cardiovascular Agents |
MeSH PA | D002491 | Central Nervous System Agents |
MeSH PA | D004791 | Enzyme Inhibitors |
MeSH PA | D018696 | Neuroprotective Agents |
MeSH PA | D018697 | Nootropic Agents |
MeSH PA | D010726 | Phosphodiesterase Inhibitors |
MeSH PA | D020011 | Protective Agents |
MeSH PA | D014665 | Vasodilator Agents |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Dementia | indication | 52448006 |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 7.03 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A | Enzyme | IC50 | 5.10 | CHEMBL | |||||
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C | Enzyme | INHIBITOR | IC50 | 4.30 | IUPHAR | ||||
Phosphodiesterase 1 | Enzyme | IC50 | 4.72 | CHEMBL |
ID | Source |
---|---|
4024909 | VUID |
N0000171574 | NUI |
D01371 | KEGG_DRUG |
4024909 | VANDF |
C0124496 | UMLSCUI |
CHEBI:32297 | CHEBI |
CHEMBL71752 | ChEMBL_ID |
DB12131 | DRUGBANK_ID |
443955 | PUBCHEM_CID |
C013983 | MESH_SUPPLEMENTAL_RECORD_UI |
4046 | INN_ID |
543512OBTC | UNII |
5285 | IUPHAR_LIGAND_ID |
24506 | RXNORM |
005991 | NDDF |
716059001 | SNOMEDCT_US |
None