vinpocetine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
vinca alkaloids 2828 42971-09-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • cavinton
  • ethyl apovincaminate tartrate
  • vinpocetine
  • apovincaminic acid ethyl ester
  • bravinton
  • ceractin
  • ethyl apovincaminate
  • vinporal
whole issue of Arzneim Forsch (23 articles) discuss this drug; Arzneim Forsch 26(10a);1976; RN given refers to parent cpd with unspecified isomeric designation
  • Molecular weight: 350.46
  • Formula: C22H26N2O2
  • CLOGP: 4.83
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 0
  • TPSA: 34.47
  • ALOGS: -4.14
  • ROTB: 4

Drug dosage:

DoseUnitRoute
15 mg O

ADMET properties:

PropertyValueReference
BA (Bioavailability) 6.70 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 2.08 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 6.10 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.02 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 4.83 hours Lombardo F, Berellini G, Obach RS

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC N06BX18 NERVOUS SYSTEM
PSYCHOANALEPTICS
PSYCHOSTIMULANTS, AGENTS USED FOR ADHD AND NOOTROPICS
Other psychostimulants and nootropics
MeSH PA D002317 Cardiovascular Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D018696 Neuroprotective Agents
MeSH PA D018697 Nootropic Agents
MeSH PA D010726 Phosphodiesterase Inhibitors
MeSH PA D020011 Protective Agents
MeSH PA D014665 Vasodilator Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Dementia indication 52448006

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.03 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A Enzyme IC50 5.10 CHEMBL
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C Enzyme INHIBITOR IC50 4.30 IUPHAR
Phosphodiesterase 1 Enzyme IC50 4.72 CHEMBL

External reference:

IDSource
4024909 VUID
N0000171574 NUI
C0059752 UMLSCUI
D01371 KEGG_DRUG
543512OBTC UNII
4046 INN_ID
24506 RXNORM
4024909 VANDF
005991 NDDF
716059001 SNOMEDCT_US
CHEMBL71752 ChEMBL_ID
DB12131 DRUGBANK_ID
CHEBI:32297 CHEBI
443955 PUBCHEM_CID
5285 IUPHAR_LIGAND_ID
C013983 MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

None