vinpocetine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
vinca alkaloids	2828	42971-09-5

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

cavinton
ethyl apovincaminate tartrate
vinpocetine
apovincaminic acid ethyl ester
bravinton
ceractin
ethyl apovincaminate
vinporal

whole issue of Arzneim Forsch (23 articles) discuss this drug; Arzneim Forsch 26(10a);1976; RN given refers to parent cpd with unspecified isomeric designation

Molecular weight: 350.46
Formula: C22H26N2O2
CLOGP: 4.83
LIPINSKI: 0
HAC: 4
HDO: 0
TPSA: 34.47
ALOGS: -4.14
ROTB: 4

Drug dosage:

Dose	Unit	Route
15	mg	O

ADMET properties:

Property	Value	Reference
BA (Bioavailability)	6.70 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution)	2.08 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	6.10 mL/min/kg	Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)	0.02 %	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	4.83 hours	Lombardo F, Berellini G, Obach RS

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

Source	Code	Description
ATC	N06BX18	NERVOUS SYSTEM PSYCHOANALEPTICS PSYCHOSTIMULANTS, AGENTS USED FOR ADHD AND NOOTROPICS Other psychostimulants and nootropics
MeSH PA	D002317	Cardiovascular Agents
MeSH PA	D002491	Central Nervous System Agents
MeSH PA	D004791	Enzyme Inhibitors
MeSH PA	D018696	Neuroprotective Agents
MeSH PA	D018697	Nootropic Agents
MeSH PA	D010726	Phosphodiesterase Inhibitors
MeSH PA	D020011	Protective Agents
MeSH PA	D014665	Vasodilator Agents

Drug Use (View source of the data)

Disease	Relation	SNOMED_ID	DOID
Dementia	indication	52448006

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	7.03	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	Enzyme	P54750	PDE1A_HUMAN		IC50	5.10		CHEMBL
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	Enzyme	Q14123	PDE1C_HUMAN	INHIBITOR	IC50	4.30		IUPHAR
Phosphodiesterase 1	Enzyme		PDE1A_BOVIN PDE1B_BOVIN		IC50	4.72		CHEMBL

External reference:

ID	Source
4024909	VUID
N0000171574	NUI
C0059752	UMLSCUI
D01371	KEGG_DRUG
543512OBTC	UNII
4046	INN_ID
24506	RXNORM
4024909	VANDF
005991	NDDF
716059001	SNOMEDCT_US
CHEMBL71752	ChEMBL_ID
DB12131	DRUGBANK_ID
CHEBI:32297	CHEBI
443955	PUBCHEM_CID
5285	IUPHAR_LIGAND_ID
C013983	MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

None