azathioprine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
269 446-86-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • BW 57-322
  • azathioprine sulfate
  • azathioprine
  • azamune
  • azanin
  • azathioprin
  • azathropine
  • azothioprine
  • azathioprine sodium
Azathioprine is an inactive pro-drug of 6-mercaptopurine (6-MP), which acts as a purine antagonist but requires cellular uptake and intracellular anabolism to thioguanine nucleotides (TGNs) for immunosuppression. TGNs and other metabolites (e.g. 6-methylmercaptopurine ribonucleotides) inhibit de novo purine synthesis and purine nucleotide interconversions. The TGNs are also incorporated into nucleic acids and this contributes to the immunosuppressive effects of the medicinal product. Other potential mechanisms of azathioprine include the inhibition of many pathways in nucleic acid biosynthesis, hence preventing proliferation and activity of cells involved in the immune response (B and T lymphocytes). Because of these mechanisms, the therapeutic effect of azathioprine may be evident only after several weeks or months of treatment. Unlike 6-MP, the activity of the azathioprine metabolite 1-methyl-4-nitro-5-thioimidazole has not been clearly determined. However, compared with 6-MP it appears to modify the activity of azathioprine in several systems. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
  • Molecular weight: 277.26
  • Formula: C9H7N7O2S
  • CLOGP: 0.51
  • LIPINSKI: 0
  • HAC: 9
  • HDO: 1
  • TPSA: 115.42
  • ALOGS: -2.41
  • ROTB: 3
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.15 g O
0.15 g P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 10 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 1 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 18.03 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 60 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
March 20, 1968 FDA PROMETHEUS LABS
Feb. 21, 2019 PMDA ASPEN JAPAN K.K.; MITSUBISHI TANABE PHARMA CORPORATION

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Off label use 641.97 9.81 2777 128553 553403 55607334
Colitis ulcerative 556.76 9.81 459 130871 23932 56136805
Blood iron abnormal 523.87 9.81 221 131109 3156 56157581
Drug ineffective 515.53 9.81 3776 127554 915213 55245524
Exposure during pregnancy 495.55 9.81 1026 130304 135316 56025421
Drug intolerance 326.69 9.81 1352 129978 263466 55897271
Treatment failure 323.27 9.81 1002 130328 169390 55991347
Premature delivery 259.53 9.81 318 131012 26742 56133995
Lupus-like syndrome 250.94 9.81 218 131112 12209 56148528
Condition aggravated 250.22 9.81 1515 129815 343383 55817354
Death 248.81 9.81 258 131072 341168 55819569
Crohn's disease 248.20 9.81 166 131164 6261 56154476
Cytomegalovirus infection 241.14 9.81 260 131070 19036 56141701
Bone erosion 240.43 9.81 231 131099 14743 56145994
Intestinal stenosis 222.34 9.81 113 131217 2518 56158219
Product use in unapproved indication 204.11 9.81 757 130573 140065 56020672
Fall 203.76 9.81 325 131005 357185 55803552
Cushingoid 202.83 9.81 155 131175 7229 56153508
Drug level below therapeutic 192.53 9.81 122 131208 4191 56156546
Therapeutic product effect incomplete 184.83 9.81 606 130724 105425 56055312
Fistula 184.17 9.81 158 131172 8697 56152040
Demyelination 173.21 9.81 132 131198 6130 56154607
Anal fistula 168.46 9.81 98 131232 2876 56157861
SLE arthritis 164.04 9.81 60 131270 570 56160167
Fatigue 160.90 9.81 1130 130200 787422 55373315
Ileal stenosis 159.31 9.81 76 131254 1469 56159268
Therapeutic response decreased 158.35 9.81 368 130962 52390 56108347
Post transplant lymphoproliferative disorder 157.55 9.81 111 131219 4561 56156176
Frequent bowel movements 155.83 9.81 192 131138 16232 56144505
Arthritis 153.25 9.81 547 130783 99305 56061432
Premature labour 150.02 9.81 161 131169 11721 56149016
Hepatic cirrhosis 145.63 9.81 212 131118 21051 56139686
Red blood cell sedimentation rate increased 145.13 9.81 286 131044 36337 56124400
Intentional product use issue 140.98 9.81 532 130798 99201 56061536
Proteinuria 140.94 9.81 189 131141 17381 56143356
Disease recurrence 139.49 9.81 221 131109 23639 56137098
Rheumatoid arthritis 138.12 9.81 1431 129899 381173 55779564
Joint dislocation 137.89 9.81 177 131153 15596 56145141
Exostosis 137.46 9.81 172 131158 14771 56145966
Faecal calprotectin increased 135.10 9.81 82 131248 2606 56158131
Cholestasis of pregnancy 133.81 9.81 62 131268 1119 56159618
C-reactive protein increased 131.10 9.81 443 130887 78241 56082496
Confusional state 130.35 9.81 177 131153 207978 55952759
Maternal exposure during pregnancy 129.73 9.81 821 130509 188732 55972005
Toxicity to various agents 128.84 9.81 203 131127 224361 55936376
Hyponatraemia 127.06 9.81 40 131290 102099 56058638
Product dose omission issue 126.31 9.81 176 131154 204577 55956160
Epstein-Barr virus infection 125.25 9.81 118 131212 7345 56153392
Elbow deformity 124.27 9.81 63 131267 1396 56159341
Pain 123.71 9.81 974 130356 662210 55498527
Vasculitis 123.50 9.81 163 131167 14760 56145977
Large intestinal stenosis 121.20 9.81 66 131264 1700 56159037
Malignant neoplasm progression 120.21 9.81 15 131315 73572 56087165
Intestinal resection 118.51 9.81 74 131256 2476 56158261
Abortion spontaneous 118.17 9.81 293 131037 43460 56117277
Pre-eclampsia 117.87 9.81 121 131209 8365 56152372
Transplant rejection 117.39 9.81 130 131200 9804 56150933
Lupus nephritis 115.91 9.81 75 131255 2672 56158065
Impaired gastric emptying 114.29 9.81 124 131206 9139 56151598
Glossodynia 113.34 9.81 113 131217 152345 56008392
Joint stiffness 111.70 9.81 252 131078 35173 56125564
Inflammation 111.65 9.81 385 130945 68686 56092051
Drug hypersensitivity 110.15 9.81 1052 130278 274153 55886584
Haematochezia 109.98 9.81 285 131045 43433 56117304
Drug abuse 109.91 9.81 14 131316 67596 56093141
Somnolence 107.37 9.81 134 131196 163279 55997458
Osteoporosis 106.83 9.81 315 131015 51737 56109000
Diffuse large B-cell lymphoma 106.55 9.81 105 131225 6911 56153826
Retinitis 105.88 9.81 84 131246 4140 56156597
Anal abscess 104.21 9.81 83 131247 4114 56156623
Pancreatitis 102.42 9.81 283 131047 44797 56115940
Swelling 102.07 9.81 258 131072 239513 55921224
Kidney transplant rejection 101.80 9.81 82 131248 4131 56156606
Atrial fibrillation 100.59 9.81 65 131265 108832 56051905
Rheumatoid nodule 100.10 9.81 147 131183 14710 56146027
Basal cell carcinoma 99.96 9.81 197 131133 25024 56135713
Constipation 98.34 9.81 202 131128 201741 55958996
Hypotension 97.28 9.81 282 131048 250226 55910511
Abscess 96.99 9.81 146 131184 14935 56145802
Abdominal pain 93.67 9.81 969 130361 257836 55902901
Antinuclear antibody positive 92.23 9.81 96 131234 6745 56153992
Haemophagocytic lymphohistiocytosis 90.96 9.81 112 131218 9460 56151277
Therapeutic product effect decreased 90.53 9.81 691 130639 168761 55991976
Stomatitis 90.40 9.81 89 131241 120721 56040016
Cytomegalovirus viraemia 89.86 9.81 83 131247 5037 56155700
Electrocardiogram QT prolonged 89.47 9.81 11 131319 54577 56106160
Cardiac failure congestive 88.60 9.81 47 131283 87673 56073064
Cerebrovascular accident 88 9.81 62 131268 99208 56061529
Overdose 86.29 9.81 72 131258 105758 56054979
Foot deformity 84.81 9.81 178 131152 23647 56137090
Arthralgia 83.48 9.81 1637 129693 500032 55660705
Leukopenia 83.08 9.81 357 130973 70583 56090154
Tremor 81.94 9.81 97 131233 120992 56039745
Contusion 81.56 9.81 108 131222 128322 56032415
Diarrhoea haemorrhagic 81.13 9.81 97 131233 7946 56152791
Pleuritic pain 81.07 9.81 91 131239 6966 56153771
Scleritis 80.82 9.81 68 131262 3643 56157094
Product use issue 80.80 9.81 724 130606 185317 55975420
Muscle injury 80.37 9.81 13 131317 52487 56108250
Normal newborn 80.18 9.81 93 131237 7377 56153360
Hypokalaemia 79.81 9.81 62 131268 94375 56066362
Lung transplant rejection 78.93 9.81 38 131292 750 56159987
Liver function test increased 78.72 9.81 191 131139 27942 56132795
Asthenia 78.38 9.81 474 130856 342499 55818238
Inappropriate schedule of product administration 75.93 9.81 390 130940 82997 56077740
Clostridium difficile infection 75.40 9.81 184 131146 27014 56133723
Pneumocystis jirovecii pneumonia 75.17 9.81 133 131197 15568 56145169
Pemphigus 74.21 9.81 160 131170 157052 56003685
Ankylosing spondylitis 73.87 9.81 103 131227 9827 56150910
Disseminated tuberculosis 73.33 9.81 57 131273 2726 56158011
Epstein-Barr virus associated lymphoproliferative disorder 73.07 9.81 48 131282 1755 56158982
Granulomatosis with polyangiitis 73.06 9.81 51 131279 2064 56158673
Anaphylactic reaction 73.06 9.81 302 131028 58693 56102044
Anal fissure 72.92 9.81 65 131265 3766 56156971
Synovial fluid analysis 72.30 9.81 49 131281 1889 56158848
Squamous cell carcinoma 72.10 9.81 92 131238 8056 56152681
Ulcer 72.05 9.81 161 131169 22324 56138413
Pancytopenia 71.99 9.81 402 130928 88313 56072424
Hepatosplenic T-cell lymphoma 71.65 9.81 33 131297 587 56160150
Gestational hypertension 71.50 9.81 52 131278 2247 56158490
Autoimmune hepatitis 70.98 9.81 90 131240 7831 56152906
Febrile neutropenia 70.93 9.81 85 131245 105460 56055277
Dyspnoea 70.51 9.81 967 130363 591610 55569127
Anti-neutrophil cytoplasmic antibody positive vasculitis 70.45 9.81 54 131276 2529 56158208
Drug level decreased 69.30 9.81 84 131246 6980 56153757
Tenosynovitis stenosans 67.71 9.81 53 131277 2561 56158176
Loss of consciousness 67.36 9.81 94 131236 109255 56051482
Syncope 66.66 9.81 93 131237 108106 56052631
Hair follicle tumour benign 65.65 9.81 27 131303 360 56160377
Erythema nodosum 65.08 9.81 64 131266 4201 56156536
Intestinal obstruction 64.92 9.81 177 131153 27794 56132943
Cardio-respiratory arrest 64.73 9.81 24 131306 55297 56105440
Colectomy 64.50 9.81 49 131281 2264 56158473
Irritable bowel syndrome 64.39 9.81 40 131290 68418 56092319
Folliculitis 64.08 9.81 24 131306 54955 56105782
Gastrointestinal inflammation 63.80 9.81 68 131262 4910 56155827
Premature baby 63.21 9.81 139 131191 19066 56141671
Immunosuppressant drug level decreased 62.57 9.81 34 131296 872 56159865
Progressive multifocal leukoencephalopathy 61.73 9.81 105 131225 11908 56148829
Duodenal ulcer perforation 61.47 9.81 42 131288 68300 56092437
Neutrophil count decreased 61.07 9.81 20 131310 49802 56110935
Uveitis 61.06 9.81 100 131230 10995 56149742
Interstitial lung disease 60.64 9.81 279 131051 56784 56103953
Abdominal discomfort 60.30 9.81 389 130941 276885 55883852
Sedation 59.70 9.81 6 131324 34848 56125889
Lymphopenia 59.33 9.81 125 131205 16649 56144088
Blister 59.05 9.81 102 131228 108785 56051952
Blood pressure fluctuation 58.39 9.81 217 131113 40143 56120594
Angiocentric lymphoma 58.10 9.81 29 131301 621 56160116
Gastrointestinal lymphoma 57.98 9.81 16 131314 52 56160685
Aphthous ulcer 57.78 9.81 102 131228 11917 56148820
Balance disorder 57.66 9.81 56 131274 76464 56084273
Discomfort 57.62 9.81 156 131174 141605 56019132
Anxiety 57.12 9.81 244 131086 192928 55967809
Lymphoproliferative disorder 56.89 9.81 51 131279 2977 56157760
Dizziness 56.46 9.81 583 130747 375557 55785180
Depression 56.07 9.81 223 131107 179894 55980843
Product label confusion 56.01 9.81 33 131297 992 56159745
Panniculitis 55.92 9.81 90 131240 9752 56150985
Immunosuppressant drug level increased 55.67 9.81 52 131278 3201 56157536
Wound 55.48 9.81 154 131176 138650 56022087
Histoplasmosis disseminated 55.30 9.81 36 131294 1296 56159441
Central nervous system lymphoma 54.94 9.81 38 131292 1515 56159222
Helicobacter infection 54.76 9.81 54 131276 73214 56087523
Hallucination 54.75 9.81 23 131307 49126 56111611
Intentional overdose 54.71 9.81 47 131283 68070 56092667
Hypogammaglobulinaemia 54.42 9.81 71 131259 6355 56154382
Impaired healing 54.13 9.81 74 131256 86767 56073970
Neuromyelitis optica spectrum disorder 54.13 9.81 33 131297 1057 56159680
Overlap syndrome 53.93 9.81 28 131302 653 56160084
Seizure 53.67 9.81 134 131196 124985 56035752
Caesarean section 53.57 9.81 117 131213 15974 56144763
Plasma cell myeloma 53.31 9.81 21 131309 46625 56114112
Cytomegalovirus colitis 53.11 9.81 42 131288 2060 56158677
Depressed level of consciousness 53.03 9.81 33 131297 56400 56104337
Premature separation of placenta 52.90 9.81 39 131291 1721 56159016
Insomnia 52.73 9.81 249 131081 191611 55969126
Lupus vasculitis 52.41 9.81 25 131305 483 56160254
Agitation 52.34 9.81 33 131297 56003 56104734
Platelet count decreased 51.24 9.81 107 131223 106276 56054461
Osteonecrosis 51.00 9.81 144 131186 23071 56137666
Hand deformity 50.27 9.81 154 131176 134338 56026399
Pulmonary tuberculosis 50.19 9.81 57 131273 4419 56156318
Diabetes mellitus 49.64 9.81 249 131081 52486 56108251
Therapeutic product effect variable 47.69 9.81 31 131299 1113 56159624
Dermatomyositis 47.53 9.81 44 131286 2678 56158059
Impaired work ability 47.42 9.81 105 131225 14467 56146270
Suicidal ideation 47.40 9.81 39 131291 57703 56103034
Tuberculosis 47.19 9.81 89 131241 10940 56149797
Orthostatic hypotension 47 9.81 10 131320 33189 56127548
Pulmonary mass 46.97 9.81 129 131201 20341 56140396
Coma 46.89 9.81 42 131288 59613 56101124
Papilloma viral infection 46.77 9.81 33 131297 1359 56159378
Musculoskeletal stiffness 46.71 9.81 563 130767 155444 56005293
Cardiac arrest 46.66 9.81 81 131249 86233 56074504
Intestinal fistula 46.39 9.81 27 131303 793 56159944
Epstein-Barr virus test positive 46.06 9.81 24 131306 564 56160173
Injection site swelling 46.02 9.81 22 131308 43556 56117181
C-reactive protein abnormal 46.01 9.81 189 131141 36620 56124117
Blood glucose increased 45.88 9.81 65 131265 75086 56085651
Chronic allograft nephropathy 45.63 9.81 25 131305 652 56160085
Bradycardia 44.67 9.81 55 131275 67449 56093288
Injection site erythema 44.36 9.81 70 131260 77378 56083359
Listeriosis 44.09 9.81 32 131298 1378 56159359
Premature rupture of membranes 44.06 9.81 55 131275 4710 56156027
Live birth 43.45 9.81 122 131208 19483 56141254
Intentional product misuse 43.26 9.81 34 131296 51470 56109267
Back pain 43.18 9.81 350 130980 236820 55923917
Myasthenia gravis 43.06 9.81 52 131278 4304 56156433
Histoplasmosis 42.84 9.81 35 131295 1799 56158938
Pulmonary fibrosis 42.21 9.81 159 131171 29599 56131138
Wrong technique in product usage process 42.18 9.81 44 131286 58124 56102613
Tenosynovitis 41.93 9.81 91 131239 12370 56148367
Colitis 41.91 9.81 201 131129 41610 56119127
Serotonin syndrome 41.82 9.81 6 131324 26484 56134253
Renal impairment 41.30 9.81 326 131004 80387 56080350
B-cell lymphoma 41.22 9.81 45 131285 3339 56157398
Skin ulcer 41.18 9.81 189 131141 38419 56122318
Bone pain 41.07 9.81 34 131296 50151 56110586
Nicotinic acid deficiency 40.98 9.81 12 131318 51 56160686
Dehydration 40.82 9.81 211 131119 158614 56002123
Hypoglycaemia 40.72 9.81 42 131288 55773 56104964
Phospholipidosis 40.61 9.81 12 131318 53 56160684
Suicide attempt 40.55 9.81 45 131285 57791 56102946
Laryngitis 40.50 9.81 96 131234 13834 56146903
Drug ineffective for unapproved indication 40.44 9.81 142 131188 25551 56135186
Mycobacterial infection 40.38 9.81 33 131297 1697 56159040
Metabolic acidosis 40.36 9.81 22 131308 40432 56120305
Foetal exposure during pregnancy 40.19 9.81 171 131159 33652 56127085
Decreased appetite 40.14 9.81 323 131007 218908 55941829
Episcleritis 40.11 9.81 26 131304 929 56159808
Full blood count decreased 40.04 9.81 4 131326 23345 56137392
Pneumonia cytomegaloviral 39.98 9.81 35 131295 1979 56158758
Chronic obstructive pulmonary disease 39.89 9.81 45 131285 57370 56103367
Drug specific antibody present 39.89 9.81 46 131284 3626 56157111
Granuloma skin 39.41 9.81 64 131266 6987 56153750
Ileostomy 39.35 9.81 29 131301 1279 56159458
Therapeutic response shortened 39.24 9.81 75 131255 9311 56151426
Neoplasm progression 38.98 9.81 13 131317 32003 56128734
Fungal endocarditis 38.73 9.81 16 131314 216 56160521
Intentional self-injury 38.67 9.81 6 131324 24986 56135751
Squamous cell carcinoma of skin 38.65 9.81 55 131275 5347 56155390
Hyperkalaemia 38.57 9.81 37 131293 50828 56109909
Sleep disorder due to general medical condition, insomnia type 38.48 9.81 27 131303 43311 56117426
Joint swelling 38.18 9.81 915 130415 288885 55871852
Respiratory arrest 38.05 9.81 12 131318 30613 56130124
Antiphospholipid syndrome 38.00 9.81 31 131299 1590 56159147
Palmar-plantar erythrodysaesthesia syndrome 37.77 9.81 3 131327 21062 56139675
Clear cell renal cell carcinoma 37.74 9.81 28 131302 1248 56159489
Blood parathyroid hormone decreased 37.67 9.81 69 131261 8295 56152442
Foetal death 37.62 9.81 70 131260 8517 56152220
Neuropathy peripheral 37.60 9.81 119 131211 102774 56057963
Small intestinal obstruction 37.58 9.81 105 131225 16720 56144017
Disseminated cytomegaloviral infection 37.31 9.81 15 131315 188 56160549
Muscle fatigue 37.25 9.81 36 131294 2313 56158424
Crepitations 37.16 9.81 62 131268 6922 56153815
Drug tolerance 37.08 9.81 57 131273 5937 56154800
Female genital tract fistula 37.06 9.81 49 131281 4443 56156294
Low birth weight baby 36.61 9.81 58 131272 6200 56154537
Epicondylitis 36.04 9.81 33 131297 1980 56158757
Multiple sclerosis relapse 36.03 9.81 31 131299 44872 56115865
Injection site inflammation 35.78 9.81 42 131288 3374 56157363
Acute kidney injury 35.32 9.81 375 130955 240388 55920349
Subcutaneous abscess 35.19 9.81 51 131279 5041 56155696
Foetal growth restriction 35.10 9.81 61 131269 7038 56153699
Hyperhidrosis 34.96 9.81 108 131222 93980 56066757
Intestinal fibrosis 34.95 9.81 13 131317 130 56160607
Cholangitis sclerosing 34.80 9.81 28 131302 1408 56159329
Myositis 34.59 9.81 67 131263 8401 56152336
Drug tolerance decreased 34.30 9.81 88 131242 13323 56147414
Medication error 34.25 9.81 29 131301 42306 56118431
Injection site bruising 34.20 9.81 24 131306 38497 56122240
Enterocutaneous fistula 34.08 9.81 26 131304 1209 56159528
Abdominal adhesions 34.04 9.81 38 131292 2891 56157846
Secondary immunodeficiency 33.99 9.81 26 131304 1214 56159523
Pyoderma gangrenosum 33.91 9.81 40 131290 3230 56157507
Restlessness 33.79 9.81 10 131320 26576 56134161
Arthritis enteropathic 33.78 9.81 15 131315 244 56160493
Accidental exposure to product 33.73 9.81 8 131322 24639 56136098
Cardiac failure 33.60 9.81 90 131240 82003 56078734
Chorioretinopathy 33.31 9.81 22 131308 812 56159925
Renal mass 33.27 9.81 32 131298 2044 56158693
White blood cell count decreased 33.15 9.81 166 131164 125824 56034913
Hepatitis 33.11 9.81 167 131163 35274 56125463
Rectal discharge 32.86 9.81 19 131311 551 56160186
Fluid retention 32.78 9.81 47 131283 54031 56106706
Lactic acidosis 32.75 9.81 21 131309 35325 56125412
Laryngeal disorder 32.66 9.81 23 131307 944 56159793
Immunosuppression 32.51 9.81 63 131267 7901 56152836
Inflammatory bowel disease 32.48 9.81 42 131288 3726 56157011
Drug withdrawal syndrome 32.36 9.81 10 131320 25847 56134890
Liver transplant rejection 32.20 9.81 26 131304 1314 56159423
Drug level above therapeutic 32.08 9.81 45 131285 4317 56156420
Bone marrow failure 32.07 9.81 141 131189 28145 56132592
Pregnancy 31.81 9.81 157 131173 32876 56127861
Sleep disorder 31.79 9.81 69 131261 67594 56093143
Therapeutic reaction time decreased 31.74 9.81 29 131301 1735 56159002
Device dislocation 31.61 9.81 7 131323 22599 56138138
Cognitive disorder 31.50 9.81 41 131289 49092 56111645
Bronchiectasis 31.31 9.81 77 131253 11357 56149380
Feeling abnormal 31.30 9.81 183 131147 133419 56027318
Pneumatosis intestinalis 31.30 9.81 32 131298 2201 56158536
Proctitis 31.11 9.81 34 131296 2526 56158211
Nausea 30.97 9.81 1463 129867 762715 55398022
Myasthenia gravis crisis 30.87 9.81 17 131313 448 56160289
Nephrotic syndrome 30.84 9.81 49 131281 5251 56155486
Heart transplant rejection 30.80 9.81 17 131313 450 56160287
Abdominal abscess 30.70 9.81 43 131287 4119 56156618
Dyskinesia 30.27 9.81 15 131315 29093 56131644
Blood calcium decreased 30.10 9.81 9 131321 23760 56136977
Urinary retention 29.91 9.81 14 131316 28060 56132677
Mycobacterium abscessus infection 29.87 9.81 19 131311 657 56160080
Rectal abscess 29.75 9.81 23 131307 1091 56159646
Coombs positive haemolytic anaemia 29.72 9.81 15 131315 329 56160408
Nasopharyngitis 29.70 9.81 351 130979 220608 55940129
Asthma 29.43 9.81 149 131181 112621 56048116
Natural killer-cell leukaemia 29.40 9.81 11 131319 112 56160625
Cervical dysplasia 29.28 9.81 35 131295 2866 56157871
Sinusitis 29.27 9.81 307 131023 197274 55963463
Eye infection toxoplasmal 29.23 9.81 14 131316 273 56160464
Aspergillus infection 29.20 9.81 58 131272 7407 56153330
Trichodysplasia spinulosa 29.12 9.81 17 131313 502 56160235
Hypomagnesaemia 29.01 9.81 11 131319 25004 56135733
Abdominal pain upper 28.94 9.81 271 131059 178042 55982695
Encephalopathy 28.82 9.81 24 131306 35301 56125436
Scleroderma renal crisis 28.78 9.81 14 131316 283 56160454
Mental status changes 28.76 9.81 27 131303 37474 56123263
Hepatic fibrosis 28.68 9.81 37 131293 3275 56157462
Plasmablastic lymphoma 28.55 9.81 14 131316 288 56160449
Adverse reaction 28.53 9.81 66 131264 9361 56151376
Skin necrosis 28.46 9.81 78 131252 12283 56148454
Synovial cyst 28.43 9.81 65 131265 9149 56151588
Jaw fracture 28.31 9.81 32 131298 2468 56158269
Complications of bone marrow transplant 28.11 9.81 16 131314 450 56160287
Extrapulmonary tuberculosis 28.04 9.81 14 131316 300 56160437
Ganglioneuroma 27.86 9.81 11 131319 131 56160606
Peripheral swelling 27.78 9.81 383 130947 234343 55926394
Cardiac disorder 27.69 9.81 40 131290 45847 56114890
Injection site pain 27.66 9.81 160 131170 116958 56043779
Meningitis cryptococcal 27.47 9.81 23 131307 1224 56159513
Therapy interrupted 26.96 9.81 13 131317 25612 56135125
Renal transplant failure 26.88 9.81 18 131312 680 56160057
Serum sickness 26.87 9.81 32 131298 2610 56158127
Conjunctivitis 26.87 9.81 98 131232 17962 56142775
Rhegmatogenous retinal detachment 26.80 9.81 10 131320 101 56160636
Abscess intestinal 26.62 9.81 24 131306 1411 56159326
Rectal cancer metastatic 26.58 9.81 13 131317 266 56160471
Unresponsive to stimuli 26.57 9.81 21 131309 31704 56129033
Antinuclear antibody negative 26.55 9.81 12 131318 204 56160533
Vomiting 26.53 9.81 924 130406 497304 55663433
Klebsiella infection 26.50 9.81 57 131273 7699 56153038
Sopor 26.35 9.81 8 131322 20914 56139823
Mycobacterium avium complex infection 26.34 9.81 33 131297 2836 56157901
Gastrointestinal haemorrhage 26.25 9.81 90 131240 75861 56084876
Eosinophilic granulomatosis with polyangiitis 26.14 9.81 28 131302 2033 56158704
Kaposi's sarcoma 26.07 9.81 11 131319 157 56160580
Anogenital warts 25.97 9.81 15 131315 434 56160303
Paraesthesia 25.89 9.81 188 131142 130326 56030411
Polymyositis 25.85 9.81 26 131304 1754 56158983
Myocardial infarction 25.80 9.81 120 131210 92750 56067987
Varicella zoster virus infection 25.79 9.81 31 131299 2553 56158184
Antisynthetase syndrome 25.75 9.81 9 131321 74 56160663
Nodular regenerative hyperplasia 25.58 9.81 15 131315 447 56160290
Rheumatoid lung 25.52 9.81 34 131296 3106 56157631
Tractional retinal detachment 25.48 9.81 8 131322 45 56160692
Fistula discharge 25.47 9.81 20 131310 971 56159766
Thiopurine methyltransferase decreased 25.44 9.81 13 131317 293 56160444
Dysgeusia 25.35 9.81 35 131295 40880 56119857
Product quality issue 25.35 9.81 22 131308 31714 56129023
Pneumonia aspiration 25.25 9.81 23 131307 32388 56128349
Infectious mononucleosis 25.18 9.81 26 131304 1809 56158928
Meningoencephalitis viral 25.12 9.81 13 131317 301 56160436
Hydrops foetalis 25.10 9.81 15 131315 463 56160274
Congenital osteodystrophy 25.08 9.81 7 131323 24 56160713
Somatic delusion 25.08 9.81 16 131314 556 56160181
Tuberculosis of eye 25.08 9.81 7 131323 24 56160713
Flank pain 25.03 9.81 82 131248 14243 56146494
Rectal stenosis 24.88 9.81 11 131319 177 56160560
Salmonellosis 24.80 9.81 20 131310 1009 56159728
Wrist deformity 24.77 9.81 26 131304 1844 56158893
Muscular dystrophy 24.77 9.81 8 131322 50 56160687
Delirium 24.75 9.81 38 131292 42479 56118258
Anorectal disorder 24.72 9.81 24 131306 1551 56159186
Drug-induced liver injury 24.59 9.81 151 131179 34311 56126426
Myelosuppression 24.53 9.81 93 131237 17362 56143375
Small intestinal stenosis 24.31 9.81 15 131315 491 56160246
HELLP syndrome 24.29 9.81 19 131311 917 56159820
Intestinal mucosal hypertrophy 24.28 9.81 11 131319 188 56160549
Bronchitis 24.14 9.81 158 131172 112153 56048584
Lipase increased 24.09 9.81 60 131270 8919 56151818
Body temperature fluctuation 24.07 9.81 27 131303 2065 56158672
Pneumocystis jirovecii infection 24.03 9.81 22 131308 1320 56159417
Joint effusion 24.01 9.81 83 131247 14815 56145922
Abscess rupture 24.00 9.81 12 131318 258 56160479
Ileectomy 23.75 9.81 10 131320 142 56160595
Accidental overdose 23.73 9.81 9 131321 20452 56140285
Creatinine renal clearance decreased 23.69 9.81 3 131327 14556 56146181
Ear infection 23.52 9.81 139 131191 31156 56129581
Glomerulosclerosis 23.45 9.81 13 131317 347 56160390
Sleep apnoea syndrome 23.45 9.81 16 131314 26045 56134692
Pruritus 23.45 9.81 561 130769 316062 55844675
Red blood cell sedimentation rate abnormal 23.43 9.81 96 131234 18577 56142160
Emotional distress 23.33 9.81 21 131309 29742 56130995
Disturbance in attention 23.16 9.81 25 131305 32515 56128222
Herpes simplex hepatitis 23.06 9.81 13 131317 359 56160378
Neoplasm malignant 22.87 9.81 124 131206 26931 56133806
Dementia 22.65 9.81 6 131324 17152 56143585
Congenital cytomegalovirus infection 22.62 9.81 6 131324 16 56160721
Colectomy total 22.61 9.81 10 131320 161 56160576
Rectal haemorrhage 22.60 9.81 170 131160 41297 56119440
International normalised ratio increased 22.31 9.81 43 131287 43998 56116739
Tuberculosis of central nervous system 22.30 9.81 13 131317 383 56160354
Bursitis infective 22.23 9.81 21 131309 1311 56159426
Muscle spasms 22.19 9.81 209 131121 137162 56023575
Femur fracture 22.04 9.81 36 131294 39259 56121478
Disorientation 22.01 9.81 32 131298 36581 56124156
Intestinal anastomosis 21.97 9.81 13 131317 394 56160343
Varicella 21.94 9.81 24 131306 1785 56158952
Faecal calprotectin abnormal 21.87 9.81 8 131322 76 56160661
Ill-defined disorder 21.85 9.81 84 131246 68459 56092278
Device issue 21.76 9.81 11 131319 21095 56139642
Neutropenia 21.72 9.81 250 131080 157917 56002820
Hypocalcaemia 21.71 9.81 21 131309 28739 56131998
Anal cancer 21.70 9.81 14 131316 496 56160241
Congenital syphilitic osteochondritis 21.63 9.81 6 131324 20 56160717
Cytomegalovirus hepatitis 21.46 9.81 12 131318 326 56160411
Spinal cord infection 21.38 9.81 15 131315 612 56160125
Porokeratosis 21.24 9.81 9 131321 130 56160607
Oesophageal squamous cell carcinoma 21.17 9.81 9 131321 131 56160606
Gastrointestinal stoma output abnormal 21.12 9.81 7 131323 48 56160689
Poor venous access 21.10 9.81 70 131260 12236 56148501
Aplasia pure red cell 21.06 9.81 37 131293 4305 56156432
Pulmonary oedema 20.97 9.81 56 131274 51087 56109650
Anal ulcer 20.90 9.81 14 131316 529 56160208
Defaecation urgency 20.86 9.81 32 131298 3327 56157410
Vision blurred 20.84 9.81 111 131219 82832 56077905
Epistaxis 20.82 9.81 83 131247 66940 56093797
Hepatosplenomegaly 20.79 9.81 27 131303 2406 56158331
Allergy to chemicals 20.79 9.81 27 131303 2406 56158331
Mucous stools 20.68 9.81 32 131298 3352 56157385
Primary biliary cholangitis 20.57 9.81 19 131311 1153 56159584
Cough 20.53 9.81 456 130874 259505 55901232
Transient ischaemic attack 20.53 9.81 29 131301 33548 56127189
Cholesteatoma 20.46 9.81 9 131321 143 56160594
Metastases to bone 20.36 9.81 10 131320 19498 56141239
Adverse drug reaction 20.32 9.81 237 131093 64895 56095842
Actinomycotic skin infection 20.25 9.81 4 131326 0 56160737
Nocardiosis 20.23 9.81 23 131307 1785 56158952
Gait disturbance 20.21 9.81 264 131066 163057 55997680
Pleural effusion 20.06 9.81 117 131213 85363 56075374
Strongyloidiasis 20.04 9.81 19 131311 1192 56159545
Sebaceous carcinoma 20.04 9.81 6 131324 28 56160709
Poisoning 20.00 9.81 3 131327 12810 56147927
Withdrawal syndrome 19.99 9.81 9 131321 18453 56142284
Skin lesion 19.90 9.81 123 131207 28012 56132725
Arthropathy 19.86 9.81 338 130992 199937 55960800
Lethargy 19.85 9.81 58 131272 51383 56109354
Weight decreased 19.85 9.81 717 130613 239997 55920740
Abnormal faeces 19.81 9.81 38 131292 4730 56156007
T-cell lymphoma 19.80 9.81 15 131315 690 56160047
Cavernous sinus thrombosis 19.70 9.81 9 131321 157 56160580
Lupus myocarditis 19.67 9.81 7 131323 61 56160676
Underdose 19.55 9.81 16 131314 23741 56136996
Pulmonary embolism 19.50 9.81 158 131172 106966 56053771
Corynebacterium infection 19.46 9.81 13 131317 489 56160248
Hirsutism 19.42 9.81 18 131312 1097 56159640
Proctalgia 19.42 9.81 41 131289 5468 56155269
Antineutrophil cytoplasmic antibody increased 19.37 9.81 7 131323 64 56160673
Epidermodysplasia verruciformis 19.37 9.81 7 131323 64 56160673
Anaplastic large cell lymphoma T- and null-cell types 19.28 9.81 7 131323 65 56160672
Fistula of small intestine 19.24 9.81 11 131319 312 56160425
Chronic hepatitis 19.20 9.81 16 131314 846 56159891
Epstein-Barr virus associated lymphoma 19.16 9.81 13 131317 502 56160235
Central nervous system vasculitis 19.13 9.81 16 131314 850 56159887
Lymphadenopathy 18.99 9.81 144 131186 35064 56125673
Hyperadrenocorticism 18.99 9.81 11 131319 320 56160417
Atypical haemolytic uraemic syndrome 18.95 9.81 14 131316 620 56160117
Trichostasis spinulosa 18.94 9.81 5 131325 13 56160724
Actinic keratosis 18.88 9.81 25 131305 2270 56158467
Abnormal behaviour 18.84 9.81 12 131318 20260 56140477
Brain abscess 18.83 9.81 23 131307 1926 56158811
Pericarditis 18.77 9.81 163 131167 108760 56051977
Anastomotic stenosis 18.74 9.81 10 131320 247 56160490
Bowel movement irregularity 18.73 9.81 36 131294 4487 56156250
External auditory canal atresia 18.73 9.81 7 131323 71 56160666
Gastrointestinal fistula 18.71 9.81 12 131318 421 56160316
Injury 18.66 9.81 74 131256 59777 56100960
Candida infection 18.65 9.81 113 131217 25554 56135183
Headache 18.65 9.81 1091 130239 557953 55602784
Metastases to central nervous system 18.58 9.81 3 131327 12133 56148604
Malignant polyp 18.54 9.81 9 131321 181 56160556
Nightmare 18.53 9.81 8 131322 16818 56143919
Memory impairment 18.48 9.81 122 131208 86435 56074302
Anaemia 18.43 9.81 479 130851 267032 55893705
Small intestine carcinoma 18.38 9.81 12 131318 434 56160303
Muscle spasticity 18.30 9.81 12 131318 19948 56140789
Gastrointestinal scarring 18.17 9.81 10 131320 263 56160474
Transient hypogammaglobulinaemia of infancy 18.12 9.81 6 131324 41 56160696
Transaminases increased 18.03 9.81 122 131208 28648 56132089
Lung abscess 18.01 9.81 21 131309 1675 56159062
Atypical mycobacterial infection 17.90 9.81 16 131314 930 56159807
Hip fracture 17.81 9.81 22 131308 26951 56133786
Inappropriate antidiuretic hormone secretion 17.80 9.81 5 131325 13751 56146986
Diabetic ketoacidosis 17.78 9.81 11 131319 18860 56141877
Deep vein thrombosis 17.72 9.81 106 131224 76871 56083866
Cerebral toxoplasmosis 17.71 9.81 15 131315 811 56159926
Gestational diabetes 17.69 9.81 50 131280 8014 56152723
Weber tuning fork test abnormal 17.68 9.81 7 131323 84 56160653
Irritability 17.65 9.81 26 131304 29562 56131175
Appendicitis 17.61 9.81 47 131283 7285 56153452
Steroid dependence 17.49 9.81 12 131318 472 56160265
Pseudoxanthoma elasticum-like syndrome 17.49 9.81 4 131326 4 56160733
Mitochondrial neurogastrointestinal encephalopathy 17.49 9.81 4 131326 4 56160733
Coronary artery disease 17.47 9.81 28 131302 30768 56129969
Mucosal inflammation 17.46 9.81 47 131283 42763 56117974
Tonsillitis 17.42 9.81 38 131292 5182 56155555
Oral lichen planus 17.37 9.81 13 131317 587 56160150
Bronchomalacia 17.21 9.81 9 131321 213 56160524
Osteoarthritis 17.17 9.81 273 131057 80023 56080714
Herpes simplex reactivation 17.14 9.81 12 131318 488 56160249
Abortion missed 17.06 9.81 20 131310 1604 56159133
Renal tubular atrophy 17.01 9.81 14 131316 727 56160010
Ileostomy closure 16.94 9.81 8 131322 151 56160586
Dry skin 16.84 9.81 55 131275 47054 56113683
Dysplasia 16.83 9.81 15 131315 869 56159868
Blood glucose decreased 16.80 9.81 12 131318 19075 56141662
Migraine 16.74 9.81 126 131204 86671 56074066
Melaena 16.74 9.81 25 131305 28265 56132472
Aspergillosis oral 16.69 9.81 6 131324 54 56160683
Drug level abnormal 16.65 9.81 7 131323 99 56160638
Loss of therapeutic response 16.64 9.81 10 131320 312 56160425
Retinal injury 16.59 9.81 9 131321 230 56160507
Eye ulcer 16.58 9.81 10 131320 314 56160423
Anorectal stenosis 16.58 9.81 5 131325 24 56160713
Fear 16.56 9.81 7 131323 14901 56145836
Thrombotic microangiopathy 16.56 9.81 54 131276 9357 56151380
Gastrointestinal wall thickening 16.48 9.81 17 131313 1182 56159555
Intestinal polyp 16.44 9.81 18 131312 1340 56159397
Injection site pruritus 16.38 9.81 47 131283 41884 56118853
Obstructive airways disorder 16.38 9.81 10 131320 17272 56143465
Carcinoid tumour pulmonary 16.32 9.81 11 131319 420 56160317
Small intestinal resection 16.30 9.81 11 131319 421 56160316
Granuloma 16.15 9.81 38 131292 5449 56155288
Product administration error 16.13 9.81 15 131315 20914 56139823
Symptom masked 16.12 9.81 13 131317 656 56160081
Palatal ulcer 16.04 9.81 6 131324 61 56160676
Enterostomy 16.04 9.81 8 131322 171 56160566
Hypervolaemia 16.03 9.81 23 131307 26435 56134302
Pancreatitis acute 16.02 9.81 107 131223 25017 56135720
Proctectomy 15.96 9.81 6 131324 62 56160675
Opportunistic infection 15.93 9.81 20 131310 1723 56159014
B-cell unclassifiable lymphoma high grade 15.88 9.81 4 131326 8 56160729
Mouth ulceration 15.86 9.81 121 131209 29519 56131218
Chorioretinitis 15.84 9.81 12 131318 552 56160185
Polyhydramnios 15.82 9.81 22 131308 2093 56158644
Malignant melanoma 15.81 9.81 58 131272 10661 56150076
Meningitis listeria 15.79 9.81 12 131318 555 56160182
Throat cancer 15.79 9.81 12 131318 555 56160182
Synovitis 15.71 9.81 490 130840 160815 55999922
Dyspepsia 15.71 9.81 122 131208 83349 56077388
American trypanosomiasis 15.70 9.81 6 131324 65 56160672
Dysarthria 15.70 9.81 44 131286 39506 56121231
Exercise tolerance increased 15.66 9.81 5 131325 30 56160707
Pulmonary necrosis 15.65 9.81 7 131323 116 56160621
Hyperglycaemia 15.63 9.81 42 131288 38239 56122498
Therapy non-responder 15.62 9.81 215 131115 61140 56099597
Congenital bowing of long bones 15.62 9.81 6 131324 66 56160671
Complications of transplanted kidney 15.62 9.81 23 131307 2306 56158431
Peritonitis 15.59 9.81 77 131253 16125 56144612
Acute febrile neutrophilic dermatosis 15.59 9.81 25 131305 2700 56158037
Haematoma 15.58 9.81 32 131298 31987 56128750
Gingival hypertrophy 15.58 9.81 18 131312 1422 56159315
Aggression 15.56 9.81 17 131313 21989 56138748
Ejection fraction decreased 15.55 9.81 14 131316 19827 56140910
Muscle rigidity 15.55 9.81 3 131327 10668 56150069
Injection site mass 15.53 9.81 10 131320 16783 56143954
Squamous cell carcinoma of the tongue 15.39 9.81 10 131320 359 56160378
Injection site warmth 15.33 9.81 7 131323 14236 56146501
Therapy cessation 15.27 9.81 25 131305 27239 56133498
Pelvic abscess 15.25 9.81 18 131312 1454 56159283
Stress at work 15.24 9.81 16 131314 1135 56159602
Macular degeneration 15.23 9.81 13 131317 18895 56141842
Pollakiuria 15.18 9.81 22 131308 25180 56135557
Microsporidia infection 15.17 9.81 9 131321 274 56160463
Acute myocardial infarction 15.11 9.81 30 131300 30363 56130374
Microscopic polyangiitis 15.09 9.81 8 131322 195 56160542
Hot flush 15.06 9.81 57 131273 46669 56114068
Rebound effect 15.05 9.81 30 131300 3840 56156897
Heart rate irregular 15.00 9.81 91 131239 20588 56140149
Acne conglobata 14.99 9.81 4 131326 11 56160726
Takayasu's arteritis 14.99 9.81 4 131326 11 56160726
Neoplasm skin 14.98 9.81 16 131314 1158 56159579
Head injury 14.98 9.81 22 131308 25044 56135693
Anaplastic large-cell lymphoma 14.97 9.81 7 131323 129 56160608
Dermatitis psoriasiform 14.95 9.81 20 131310 1834 56158903
Knee arthroplasty 14.92 9.81 53 131277 44206 56116531
Urinary incontinence 14.88 9.81 29 131301 29556 56131181
Cleft lip and palate 14.88 9.81 10 131320 380 56160357
Oral pain 14.83 9.81 24 131306 26269 56134468
Anal squamous cell carcinoma 14.81 9.81 10 131320 383 56160354
Immune-mediated myositis 14.78 9.81 16 131314 1176 56159561
Depressed mood 14.77 9.81 40 131290 36319 56124418
DNA antibody 14.76 9.81 5 131325 37 56160700
Retinal toxicity 14.73 9.81 16 131314 1180 56159557
Meningitis aseptic 14.66 9.81 32 131298 4367 56156370
Upper gastrointestinal haemorrhage 14.65 9.81 11 131319 17043 56143694
Patent ductus arteriosus 14.62 9.81 30 131300 3921 56156816
Breast cancer metastatic 14.59 9.81 9 131321 15460 56145277
Photophobia 14.55 9.81 75 131255 15975 56144762
Infusion related reaction 14.54 9.81 611 130719 208320 55952417
Adenocarcinoma of colon 14.46 9.81 23 131307 2467 56158270
Thrombocytopenia 14.46 9.81 227 131103 135997 56024740
Cervix carcinoma 14.41 9.81 25 131305 2880 56157857
Rectal tenesmus 14.40 9.81 12 131318 634 56160103
Tonsillar hypertrophy 14.38 9.81 14 131316 908 56159829
Acute respiratory distress syndrome 14.36 9.81 94 131236 21832 56138905
Lacrimation increased 14.32 9.81 13 131317 18335 56142402
Listeria sepsis 14.31 9.81 12 131318 640 56160097
Dysphonia 14.29 9.81 50 131280 41897 56118840
Complex regional pain syndrome 14.29 9.81 21 131309 2102 56158635
Cranial sutures widening 14.27 9.81 4 131326 14 56160723
Tuberous sclerosis complex 14.26 9.81 6 131324 85 56160652
Cutaneous leishmaniasis 14.26 9.81 6 131324 85 56160652
Impetigo 14.17 9.81 16 131314 1232 56159505
Bulimia nervosa 14.12 9.81 10 131320 414 56160323
Steatorrhoea 14.08 9.81 10 131320 416 56160321
Double stranded DNA antibody positive 14.08 9.81 9 131321 314 56160423
Anterograde amnesia 14.02 9.81 11 131319 533 56160204
Obliterative bronchiolitis 14.02 9.81 20 131310 1948 56158789
Bone density decreased 14.00 9.81 63 131267 12697 56148040
Calciphylaxis 13.97 9.81 24 131306 2743 56157994
Speech disorder 13.94 9.81 43 131287 37450 56123287
Mucormycosis 13.93 9.81 24 131306 2750 56157987
Oedema peripheral 13.91 9.81 299 131031 170955 55989782
Maternal exposure during breast feeding 13.86 9.81 28 131302 3619 56157118
Ureteral neoplasm 13.85 9.81 4 131326 16 56160721
Metastases to liver 13.85 9.81 18 131312 21568 56139169
Mental disorder 13.83 9.81 21 131309 23583 56137154
Legionella infection 13.81 9.81 10 131320 429 56160308
Abnormal palmar/plantar creases 13.81 9.81 5 131325 46 56160691
Foetal exposure during delivery 13.81 9.81 5 131325 46 56160691
Superinfection 13.81 9.81 21 131309 2167 56158570
Electrolyte imbalance 13.81 9.81 13 131317 18020 56142717
Food intolerance 13.78 9.81 24 131306 2773 56157964
Skin laceration 13.78 9.81 16 131314 20140 56140597
Intestinal anastomosis complication 13.77 9.81 8 131322 234 56160503
Blood potassium increased 13.75 9.81 12 131318 17249 56143488
Lung infiltration 13.73 9.81 66 131264 13672 56147065
Hepatitis viral 13.71 9.81 10 131320 434 56160303
Gastrointestinal oedema 13.71 9.81 15 131315 1116 56159621
Hyperthyroidism 13.70 9.81 7 131323 13345 56147392
Cytomegalovirus mucocutaneous ulcer 13.66 9.81 4 131326 17 56160720
Lymphocytopenia neonatal 13.66 9.81 4 131326 17 56160720
Pyometra 13.66 9.81 6 131324 95 56160642
Sepsis neonatal 13.61 9.81 10 131320 439 56160298
Myelitis 13.57 9.81 16 131314 1291 56159446
Anovulatory cycle 13.57 9.81 7 131323 161 56160576
Hallucination, auditory 13.48 9.81 5 131325 11519 56149218
Polyomavirus-associated nephropathy 13.39 9.81 18 131312 1659 56159078
Glomerulonephritis 13.34 9.81 18 131312 1665 56159072
Abdominal symptom 13.32 9.81 9 131321 345 56160392
Fasting 13.30 9.81 4 131326 19 56160718
Herpes virus infection 13.30 9.81 34 131296 5136 56155601
Nervousness 13.28 9.81 30 131300 28985 56131752
Chest discomfort 13.28 9.81 157 131173 98700 56062037
Endocarditis noninfective 13.27 9.81 5 131325 52 56160685
Perichondritis 13.27 9.81 5 131325 52 56160685
Failed induction of labour 13.25 9.81 9 131321 348 56160389
Cystitis 13.24 9.81 64 131266 48974 56111763
Gastrointestinal motility disorder 13.21 9.81 32 131298 4674 56156063
Mediastinal effusion 13.18 9.81 5 131325 53 56160684
Eye infection fungal 13.17 9.81 6 131324 104 56160633
Haematocrit decreased 13.16 9.81 43 131287 36786 56123951
Cafe au lait spots 13.13 9.81 4 131326 20 56160717
Congenital toxoplasmosis 13.12 9.81 3 131327 3 56160734
Infertility 13.04 9.81 12 131318 725 56160012
JC virus infection 13.02 9.81 19 131311 1890 56158847
Anal stenosis 12.98 9.81 9 131321 360 56160377
Autoimmune retinopathy 12.97 9.81 4 131326 21 56160716
Tenderness 12.95 9.81 86 131244 20069 56140668
Delusion 12.89 9.81 5 131325 11210 56149527
Myoclonus 12.81 9.81 10 131320 15193 56145544
Pseudomonas infection 12.81 9.81 52 131278 10019 56150718
Amniotic cavity infection 12.80 9.81 15 131315 1203 56159534
Amnesia 12.77 9.81 60 131270 46262 56114475
Abdominal pain lower 12.77 9.81 95 131235 22997 56137740
Sinus bradycardia 12.68 9.81 8 131322 13578 56147159
Intestinal operation 12.67 9.81 10 131320 489 56160248
Lymphoma 12.60 9.81 53 131277 10375 56150362
Haemorrhage in pregnancy 12.58 9.81 18 131312 1758 56158979
Device breakage 12.56 9.81 4 131326 10143 56150594
Affect lability 12.52 9.81 4 131326 10121 56150616
Neuropsychiatric lupus 12.49 9.81 7 131323 191 56160546
Conjunctivitis allergic 12.35 9.81 12 131318 776 56159961
Complement factor C3 decreased 12.34 9.81 8 131322 286 56160451
Burning sensation 12.32 9.81 65 131265 48631 56112106
Microtia 12.31 9.81 9 131321 392 56160345
Hypophagia 12.31 9.81 31 131299 28845 56131892
Placental necrosis 12.25 9.81 4 131326 26 56160711
Enthesopathy 12.20 9.81 44 131286 8019 56152718
Stoma site extravasation 12.17 9.81 8 131322 293 56160444
Intra-abdominal fluid collection 12.16 9.81 20 131310 2206 56158531
Threatened labour 12.16 9.81 12 131318 791 56159946
Lymphocele 12.16 9.81 12 131318 791 56159946
Anger 12.16 9.81 6 131324 11666 56149071
Feeling jittery 12.13 9.81 58 131272 11988 56148749
Muir-Torre syndrome 12.12 9.81 4 131326 27 56160710
Lacrimal haemorrhage 12.12 9.81 4 131326 27 56160710
Vertigo 12.12 9.81 76 131254 54496 56106241
Anaphylactic shock 12.11 9.81 20 131310 21720 56139017
Anastomotic complication 12.08 9.81 6 131324 127 56160610
Product storage error 12.04 9.81 8 131322 13205 56147532
Transplant dysfunction 11.99 9.81 31 131299 4715 56156022
Enterobacter infection 11.98 9.81 19 131311 2033 56158704
Fibroadenoma of breast 11.98 9.81 9 131321 409 56160328
Myopathy 11.96 9.81 50 131280 9762 56150975
Angina pectoris 11.95 9.81 30 131300 27946 56132791
Pulmonary congestion 11.90 9.81 12 131318 16103 56144634
Necrosis 11.89 9.81 32 131298 4984 56155753
Central nervous system necrosis 11.83 9.81 6 131324 133 56160604
Disease risk factor 11.81 9.81 5 131325 72 56160665
Ear pain 11.79 9.81 35 131295 30855 56129882
Cholecystitis chronic 11.79 9.81 4 131326 9744 56150993
Enterococcal sepsis 11.74 9.81 15 131315 1315 56159422
Acinetobacter infection 11.74 9.81 16 131314 1494 56159243
Cytomegalovirus chorioretinitis 11.72 9.81 17 131313 1681 56159056
Lung disorder 11.69 9.81 180 131150 52417 56108320
Contraindicated product administered 11.68 9.81 539 130791 185747 55974990
Gastrooesophageal reflux disease 11.66 9.81 131 131199 83126 56077611
Encephalitis cytomegalovirus 11.63 9.81 10 131320 552 56160185
Lymphoedema 11.61 9.81 5 131325 10525 56150212
Seronegative arthritis 11.61 9.81 22 131308 2714 56158023
Hepatitis E 11.61 9.81 15 131315 1330 56159407
Cheilitis granulomatosa 11.59 9.81 3 131327 7 56160730
DNA antibody positive 11.54 9.81 8 131322 320 56160417
Biopsy muscle abnormal 11.54 9.81 4 131326 32 56160705
Granulocyte count increased 11.51 9.81 10 131320 560 56160177
Large intestinal ulcer 11.46 9.81 24 131306 3182 56157555
Hepatitis cholestatic 11.46 9.81 37 131293 6377 56154360
Skin fissures 11.46 9.81 4 131326 9569 56151168
Kidney fibrosis 11.39 9.81 17 131313 1725 56159012
Ileal ulcer 11.37 9.81 9 131321 442 56160295
Tongue disorder 11.35 9.81 50 131280 9986 56150751
Staphylococcal skin infection 11.34 9.81 12 131318 859 56159878
Tracheal disorder 11.32 9.81 7 131323 230 56160507
Hospitalisation 11.31 9.81 116 131214 74884 56085853
Salmonella bacteraemia 11.25 9.81 6 131324 148 56160589
Panic attack 11.22 9.81 19 131311 20428 56140309
Gastrointestinal stoma complication 11.21 9.81 16 131314 1559 56159178
Lupus endocarditis 11.19 9.81 7 131323 235 56160502
Occult blood 11.18 9.81 14 131316 1203 56159534
Eye pruritus 11.16 9.81 10 131320 14196 56146541
Respiratory gas exchange disorder 11.16 9.81 8 131322 338 56160399
Blood sodium decreased 11.14 9.81 22 131308 22312 56138425
Swollen tongue 11.12 9.81 35 131295 30289 56130448
Perirectal abscess 11.07 9.81 12 131318 883 56159854
Bacillary angiomatosis 11.06 9.81 5 131325 85 56160652
Staphylococcal sepsis 11.03 9.81 40 131290 7309 56153428
Hiatus hernia 11.02 9.81 18 131312 19634 56141103
Pouchitis 11.01 9.81 9 131321 463 56160274
Restless legs syndrome 11.01 9.81 14 131316 16933 56143804
Cervical incompetence 11.01 9.81 10 131320 594 56160143
Hypoglycaemic seizure 10.99 9.81 9 131321 464 56160273
Muscle twitching 10.99 9.81 13 131317 16229 56144508
Complications of transplanted lung 10.98 9.81 7 131323 243 56160494
Hypergammaglobulinaemia 10.98 9.81 9 131321 465 56160272
Gastritis haemorrhagic 10.98 9.81 15 131315 1404 56159333
Precursor T-lymphoblastic lymphoma/leukaemia 10.94 9.81 4 131326 38 56160699
Visual impairment 10.89 9.81 238 131092 73964 56086773
Laryngeal stenosis 10.88 9.81 12 131318 901 56159836
Pharyngeal oedema 10.87 9.81 9 131321 13276 56147461
Varicella zoster pneumonia 10.84 9.81 4 131326 39 56160698
Colostomy 10.81 9.81 11 131319 752 56159985
Exfoliative rash 10.80 9.81 21 131309 2640 56158097
Tuberculin test positive 10.76 9.81 24 131306 3323 56157414
Histiocytic necrotising lymphadenitis 10.75 9.81 4 131326 40 56160697
Meningitis viral 10.71 9.81 14 131316 1255 56159482
Gastroenteritis norovirus 10.71 9.81 17 131313 1820 56158917
Mucosal necrosis 10.67 9.81 4 131326 41 56160696
Scedosporium infection 10.65 9.81 9 131321 485 56160252
Sciatica 10.64 9.81 100 131230 25910 56134827
Coloboma 10.61 9.81 5 131325 94 56160643
Burkholderia pseudomallei infection 10.59 9.81 3 131327 11 56160726
Cytopenia 10.58 9.81 48 131282 9707 56151030
Moraxella infection 10.54 9.81 8 131322 369 56160368
Proctitis ulcerative 10.53 9.81 7 131323 261 56160476
Infective pulmonary exacerbation of cystic fibrosis 10.49 9.81 3 131327 8154 56152583
Intestinal dilatation 10.46 9.81 15 131315 1468 56159269
Pseudopolyp 10.46 9.81 7 131323 264 56160473
Pyoderma 10.46 9.81 7 131323 264 56160473
Feeling hot 10.45 9.81 56 131274 41731 56119006
Drug specific antibody 10.45 9.81 18 131312 2062 56158675
Haemophilus infection 10.43 9.81 13 131317 1111 56159626
Complement factor C4 decreased 10.42 9.81 7 131323 266 56160471
Infective tenosynovitis 10.39 9.81 7 131323 267 56160470
Pulmonary venous thrombosis 10.39 9.81 3 131327 12 56160725
Pulmonary vasculitis 10.37 9.81 5 131325 99 56160638
Renal phospholipidosis 10.37 9.81 5 131325 99 56160638
Renal transplant 10.36 9.81 14 131316 1296 56159441
Stillbirth 10.35 9.81 35 131295 6179 56154558
Neutrophilic dermatosis 10.32 9.81 6 131324 176 56160561
Cholestasis 10.29 9.81 102 131228 26811 56133926
Limb discomfort 10.28 9.81 30 131300 26592 56134145
Behcet's syndrome 10.28 9.81 5 131325 101 56160636
Seasonal allergy 10.24 9.81 15 131315 17093 56143644
Renal cell carcinoma 10.20 9.81 24 131306 3441 56157296
Hodgkin's disease stage II 10.20 9.81 3 131327 13 56160724
Intestinal fistula infection 10.20 9.81 3 131327 13 56160724
Oligohydramnios 10.19 9.81 34 131296 5960 56154777
Small intestinal perforation 10.19 9.81 14 131316 1317 56159420
Hypovolaemia 10.15 9.81 5 131325 9730 56151007
Ocular toxicity 10.14 9.81 10 131320 659 56160078
Blood potassium decreased 10.14 9.81 51 131279 38621 56122116
Taste disorder 10.11 9.81 5 131325 9710 56151027
Lentigo maligna 10.11 9.81 6 131324 183 56160554
Inflammatory pain 10.09 9.81 11 131319 815 56159922
Skin exfoliation 10.05 9.81 48 131282 36852 56123885
Concussion 10.03 9.81 42 131288 8204 56152533
Infusion site thrombosis 10.02 9.81 5 131325 107 56160630
Ubiquinone decreased 10.02 9.81 3 131327 14 56160723
Primary effusion lymphoma 10.02 9.81 3 131327 14 56160723
Abnormal dreams 9.99 9.81 5 131325 9644 56151093
Hypocomplementaemia 9.99 9.81 6 131324 187 56160550
Connective tissue disorder 9.99 9.81 13 131317 1161 56159576
Bronchopulmonary aspergillosis 9.98 9.81 42 131288 8222 56152515
Necrotising retinitis 9.98 9.81 8 131322 400 56160337
Proctocolectomy 9.96 9.81 4 131326 50 56160687
Rheumatic disorder 9.95 9.81 19 131311 2357 56158380
Mental impairment 9.94 9.81 9 131321 12713 56148024
Vasculitis necrotising 9.94 9.81 9 131321 532 56160205
Osteonecrosis of jaw 9.92 9.81 42 131288 33316 56127421
Enteritis 9.92 9.81 39 131291 7404 56153333
Upper respiratory tract irritation 9.89 9.81 5 131325 110 56160627
Combined immunodeficiency 9.89 9.81 5 131325 110 56160627
Back injury 9.86 9.81 41 131289 7985 56152752
Mycetoma mycotic 9.85 9.81 3 131327 15 56160722
Ischaemic nephropathy 9.85 9.81 3 131327 15 56160722
Febrile convulsion 9.83 9.81 8 131322 409 56160328
Skin cancer 9.81 9.81 49 131281 10306 56150431

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Colitis ulcerative 734.15 10.65 478 70335 18051 31608480
Off label use 423.54 10.65 1710 69103 345564 31280967
Drug ineffective 399.70 10.65 1840 68973 393733 31232798
Death 287.08 10.65 232 70581 360337 31266194
Hepatosplenic T-cell lymphoma 267.50 10.65 82 70731 443 31626088
Drug eruption 265.44 10.65 261 70552 17926 31608605
Nodular regenerative hyperplasia 256.76 10.65 92 70721 860 31625671
Crohn's disease 234.16 10.65 134 70679 3987 31622544
Intentional product use issue 232.84 10.65 405 70408 48942 31577589
Intestinal stenosis 220.27 10.65 101 70712 1862 31624669
Fistula 210.41 10.65 141 70672 5580 31620951
Post transplant lymphoproliferative disorder 209.77 10.65 144 70669 5932 31620599
Epstein-Barr virus infection 201.28 10.65 148 70665 6805 31619726
Cytomegalovirus infection 183.11 10.65 250 70563 24457 31602074
Drug abuse 180.78 10.65 3 70810 87755 31538776
Anal abscess 180.51 10.65 129 70684 5671 31620860
Frequent bowel movements 177.27 10.65 161 70652 9998 31616533
Therapeutic product effect decreased 166.98 10.65 273 70540 31349 31595182
Hypersensitivity 166.69 10.65 378 70435 55365 31571166
Condition aggravated 163.46 10.65 762 70051 163247 31463284
Lymphoproliferative disorder 162.34 10.65 90 70723 2515 31624016
Product use issue 159.94 10.65 376 70437 56383 31570148
Completed suicide 155.89 10.65 13 70800 91501 31535030
Inappropriate schedule of product administration 149.02 10.65 342 70471 50481 31576050
Treatment failure 140.61 10.65 293 70520 40499 31586032
Febrile neutropenia 137.84 10.65 50 70763 121799 31504732
Hepatic function abnormal 136.18 10.65 291 70522 40931 31585600
Ileal stenosis 132.70 10.65 62 70751 1195 31625336
Hypotension 130.84 10.65 159 70654 204459 31422072
Intestinal obstruction 129.79 10.65 193 70620 20417 31606114
Fall 129.45 10.65 135 70678 185954 31440577
Diffuse large B-cell lymphoma 127.88 10.65 125 70688 8516 31618015
Anal fistula 125.50 10.65 96 70717 4687 31621844
Faecal calprotectin increased 119.12 10.65 66 70747 1842 31624689
Disseminated tuberculosis 115.62 10.65 68 70745 2131 31624400
Cytomegalovirus colitis 115.14 10.65 72 70741 2526 31624005
Drug level below therapeutic 114.54 10.65 93 70720 4955 31621576
Squamous cell carcinoma 114.03 10.65 130 70683 10581 31615950
Toxicity to various agents 113.91 10.65 143 70670 181344 31445187
Disease recurrence 112.16 10.65 171 70642 18490 31608041
Blood pressure fluctuation 106.35 10.65 186 70627 22550 31603981
Transplant rejection 105.34 10.65 119 70694 9589 31616942
Pemphigus 105.14 10.65 55 70758 1364 31625167
Premature baby 105 10.65 163 70650 17903 31608628
Malignant neoplasm progression 104.77 10.65 24 70789 78974 31547557
Drug level decreased 100.71 10.65 99 70714 6791 31619740
Urticaria 99.82 10.65 319 70494 57198 31569333
Haemophagocytic lymphohistiocytosis 97.01 10.65 125 70688 11553 31614978
Product use in unapproved indication 96.55 10.65 458 70355 98713 31527818
Infusion related reaction 95.99 10.65 280 70533 47775 31578756
Large intestinal stenosis 95.10 10.65 52 70761 1413 31625118
Acute febrile neutrophilic dermatosis 95.01 10.65 49 70764 1179 31625352
Dizziness 93.71 10.65 190 70623 198957 31427574
JC virus infection 92.77 10.65 57 70756 1937 31624594
Cushingoid 92.69 10.65 62 70751 2445 31624086
Leukopenia 90.76 10.65 310 70503 57518 31569013
Drug specific antibody present 89.78 10.65 64 70749 2801 31623730
Pancytopenia 89.20 10.65 409 70404 86907 31539624
Pulmonary tuberculosis 88.79 10.65 78 70735 4633 31621898
Stomatitis 88.77 10.65 240 70573 39198 31587333
Intestinal fistula 88.59 10.65 43 70770 905 31625626
Myocardial infarction 88.58 10.65 74 70739 113380 31513151
Progressive multifocal leukoencephalopathy 88.37 10.65 106 70707 9107 31617424
Colitis 87.36 10.65 217 70596 33670 31592861
Acute kidney injury 86.10 10.65 328 70485 279386 31347145
Somnolence 83.81 10.65 60 70753 99385 31527146
Pneumocystis jirovecii pneumonia 83.65 10.65 148 70665 18103 31608428
Basal cell carcinoma 82.79 10.65 147 70666 18032 31608499
Epstein-Barr virus associated lymphoproliferative disorder 82.43 10.65 51 70762 1755 31624776
Hand deformity 81.80 10.65 62 70751 2985 31623546
Cardiac failure congestive 79.42 10.65 39 70774 79348 31547183
Abscess 79.00 10.65 107 70706 10380 31616151
Dyspnoea 78.98 10.65 448 70365 343031 31283500
Atrial fibrillation 76.29 10.65 85 70728 113698 31512833
Intestinal resection 75.22 10.65 46 70767 1550 31624981
Confusional state 74.62 10.65 114 70699 133220 31493311
Therapeutic response shortened 74.59 10.65 78 70735 5759 31620772
Kidney transplant rejection 73.50 10.65 86 70727 7196 31619335
Small intestinal stenosis 73.21 10.65 30 70783 415 31626116
Epidermodysplasia verruciformis 72.84 10.65 22 70791 112 31626419
Erythema nodosum 72.62 10.65 40 70773 1103 31625428
Diarrhoea haemorrhagic 71.67 10.65 78 70735 6028 31620503
Plasma cell myeloma 71.39 10.65 19 70794 56512 31570019
Human herpesvirus 8 infection 71.11 10.65 36 70777 832 31625699
Foetal exposure during pregnancy 70.24 10.65 226 70587 40650 31585881
Nocardiosis 70 10.65 60 70753 3447 31623084
Bradycardia 69.43 10.65 34 70779 69293 31557238
Epistaxis 69.13 10.65 270 70543 53437 31573094
Squamous cell carcinoma of skin 67.98 10.65 98 70715 10076 31616455
Tuberculosis 67.27 10.65 88 70725 8253 31618278
Lymphopenia 65.41 10.65 116 70697 14213 31612318
Coombs positive haemolytic anaemia 65.02 10.65 33 70780 767 31625764
Gastrointestinal inflammation 64.01 10.65 55 70758 3170 31623361
Herpes zoster 63.46 10.65 186 70627 31807 31594724
Abdominal pain 63.45 10.65 549 70264 145403 31481128
Portal hypertension 62.95 10.65 58 70755 3667 31622864
Hyponatraemia 62.85 10.65 44 70769 73755 31552776
Cytomegalovirus viraemia 62.25 10.65 76 70737 6649 31619882
Non-cirrhotic portal hypertension 61.68 10.65 23 70790 243 31626288
Cytomegalovirus enteritis 61.67 10.65 27 70786 444 31626087
Cardiac arrest 61.38 10.65 65 70748 88997 31537534
Night sweats 61.33 10.65 119 70694 15613 31610918
Clear cell renal cell carcinoma 61.15 10.65 35 70778 1041 31625490
Immunosuppression 61.12 10.65 69 70744 5554 31620977
Lung transplant rejection 60.79 10.65 31 70782 728 31625803
Meningitis listeria 60.43 10.65 26 70787 409 31626122
Weight decreased 59.59 10.65 582 70231 159370 31467161
T-cell lymphoma 58.47 10.65 33 70780 955 31625576
Intentional overdose 58.09 10.65 11 70802 41378 31585153
Colectomy 58.07 10.65 39 70774 1548 31624983
Drug intolerance 57.05 10.65 249 70564 51784 31574747
Dehydration 56.48 10.65 113 70700 118998 31507533
Product dose omission issue 56.47 10.65 93 70720 105493 31521038
Defaecation urgency 56.07 10.65 42 70771 1986 31624545
Muscle spasms 55.52 10.65 300 70513 68018 31558513
Lymphadenitis 55.44 10.65 39 70774 1671 31624860
Anal fissure 55.26 10.65 52 70761 3377 31623154
Abdominal adhesions 54.79 10.65 35 70778 1275 31625256
Cardio-respiratory arrest 53.90 10.65 24 70789 51702 31574829
Neuropathy peripheral 53.49 10.65 54 70759 75595 31550936
Syncope 53.47 10.65 67 70746 85115 31541416
Histoplasmosis disseminated 52.99 10.65 33 70780 1149 31625382
Heart transplant rejection 52.81 10.65 33 70780 1156 31625375
Overdose 52.72 10.65 67 70746 84597 31541934
Epstein-Barr virus test positive 52.71 10.65 25 70788 499 31626032
Haematochezia 52.52 10.65 204 70609 40260 31586271
Epstein-Barr virus associated lymphoma 52.49 10.65 27 70786 646 31625885
Transplant dysfunction 51.72 10.65 43 70770 2368 31624163
Kaposi's sarcoma 50.96 10.65 29 70784 853 31625678
B-cell lymphoma 50.81 10.65 56 70757 4389 31622142
Rebound effect 50.17 10.65 43 70770 2470 31624061
Immunoglobulin G4 related disease 50.09 10.65 17 70796 133 31626398
Decreased appetite 50.09 10.65 175 70638 153042 31473489
Intestinal perforation 49.17 10.65 76 70737 8313 31618218
Pain in extremity 48.85 10.65 434 70379 115769 31510762
Blood glucose increased 48.68 10.65 39 70774 61044 31565487
Loss of consciousness 48.38 10.65 61 70752 77294 31549237
Drug level above therapeutic 48.16 10.65 50 70763 3660 31622871
Therapeutic product effect incomplete 47.81 10.65 209 70604 43487 31583044
Renal cell carcinoma 47.47 10.65 61 70752 5621 31620910
Pneumonia aspiration 47.06 10.65 14 70799 38712 31587819
Small intestinal obstruction 46.65 10.65 97 70716 13375 31613156
Acute myocardial infarction 46.39 10.65 28 70785 50795 31575736
Aggression 46.20 10.65 13 70800 37278 31589253
Chronic allograft nephropathy 46.02 10.65 30 70783 1132 31625399
Clostridium difficile infection 45.94 10.65 112 70701 17167 31609364
Aspergillus infection 45.91 10.65 88 70725 11440 31615091
Polyhydramnios 45.50 10.65 18 70795 226 31626305
Lymphoma 45.40 10.65 85 70728 10858 31615673
Delirium 45.11 10.65 18 70795 41403 31585128
Type 2 lepra reaction 44.87 10.65 20 70793 344 31626187
Cardiac failure 43.84 10.65 78 70735 85875 31540656
Rheumatoid factor negative 43.69 10.65 26 70787 833 31625698
Arthralgia 43.39 10.65 523 70290 150901 31475630
Oedema peripheral 43.35 10.65 115 70698 109724 31516807
Hypoglycaemia 42.55 10.65 31 70782 50915 31575616
Chronic obstructive pulmonary disease 42.48 10.65 24 70789 45142 31581389
Granulomatosis with polyangiitis 42.43 10.65 28 70785 1079 31625452
Inflammatory bowel disease 41.82 10.65 39 70774 2504 31624027
Systemic lupus erythematosus 41.46 10.65 42 70771 2986 31623545
Lymphocytopenia neonatal 41.37 10.65 9 70804 6 31626525
Cerebrovascular accident 40.66 10.65 72 70741 79412 31547119
Peliosis hepatis 40.41 10.65 12 70801 57 31626474
Rectal abscess 40.24 10.65 26 70787 966 31625565
International normalised ratio increased 39.78 10.65 26 70787 45197 31581334
Extrapulmonary tuberculosis 39.68 10.65 13 70800 90 31626441
Hypokalaemia 39.30 10.65 37 70776 53537 31572994
Low birth weight baby 39.25 10.65 62 70751 6908 31619623
Electrocardiogram QT prolonged 38.98 10.65 18 70795 37969 31588562
Abnormal behaviour 38.90 10.65 4 70809 23824 31602707
Vasculitis 38.74 10.65 69 70744 8481 31618050
Abscess intestinal 38.64 10.65 30 70783 1497 31625034
Weight increased 38.62 10.65 317 70496 82630 31543901
Histoplasmosis 38.55 10.65 29 70784 1380 31625151
Proctocolectomy 38.16 10.65 13 70800 103 31626428
Fistula discharge 37.62 10.65 20 70793 513 31626018
Varicella zoster virus infection 37.14 10.65 30 70783 1586 31624945
Coma 37.10 10.65 23 70790 41127 31585404
Cholangitis sclerosing 37.08 10.65 27 70786 1222 31625309
Gastrointestinal haemorrhage 36.85 10.65 81 70732 82468 31544063
Respiratory arrest 36.80 10.65 7 70806 26250 31600281
Candida infection 36.62 10.65 99 70714 16159 31610372
Hallucination 36.52 10.65 30 70783 46380 31580151
Neutrophil count decreased 36.49 10.65 30 70783 46364 31580167
Myasthenia gravis 36.31 10.65 45 70768 3998 31622533
Combined immunodeficiency 35.49 10.65 11 70802 62 31626469
Wrong technique in product usage process 35.48 10.65 15 70798 33328 31593203
Pancreatitis 35.32 10.65 166 70647 35605 31590926
Neuroendocrine carcinoma of the skin 35.17 10.65 21 70792 677 31625854
Rectal fissure 34.74 10.65 16 70797 298 31626233
Agitation 34.61 10.65 42 70771 54127 31572404
Urinary retention 34.58 10.65 16 70797 33709 31592822
Visceral leishmaniasis 34.56 10.65 19 70794 522 31626009
Mycobacterial infection 34.22 10.65 33 70780 2210 31624321
Cutaneous T-cell lymphoma 34.15 10.65 27 70786 1384 31625147
Food intolerance 34.08 10.65 26 70787 1264 31625267
Therapeutic response decreased 33.87 10.65 133 70680 26376 31600155
Foetal growth restriction 33.52 10.65 42 70771 3773 31622758
Disease progression 33.25 10.65 98 70715 90366 31536165
Mycoplasma infection 33.17 10.65 16 70797 332 31626199
Asthenia 32.97 10.65 332 70481 224423 31402108
Depressed level of consciousness 32.87 10.65 23 70790 38578 31587953
Lymphocyte count abnormal 32.80 10.65 21 70792 768 31625763
Bronchopulmonary aspergillosis 32.71 10.65 85 70728 13549 31612982
Orthostatic hypotension 32.61 10.65 7 70806 24112 31602419
Anxiety 32.46 10.65 100 70713 90933 31535598
Balance disorder 32.26 10.65 22 70791 37400 31589131
Tachycardia 32.21 10.65 77 70736 76130 31550401
Intestinal fibrosis 32.09 10.65 11 70802 89 31626442
Rectal haemorrhage 31.93 10.65 163 70650 36141 31590390
Seizure 31.87 10.65 115 70698 99653 31526878
Constipation 31.54 10.65 156 70657 123835 31502696
Lupus-like syndrome 31.27 10.65 33 70780 2462 31624069
Obliterative bronchiolitis 31.26 10.65 24 70789 1178 31625353
Heart rate irregular 31.17 10.65 86 70727 14203 31612328
Enterocutaneous fistula 31.15 10.65 21 70792 839 31625692
Serotonin syndrome 31.04 10.65 3 70810 18770 31607761
Cytomegalovirus infection reactivation 30.98 10.65 41 70772 3888 31622643
Infection reactivation 30.93 10.65 25 70788 1323 31625208
Hepatitis 30.90 10.65 114 70699 21952 31604579
Bone marrow failure 30.65 10.65 134 70679 27874 31598657
Rash 30.64 10.65 295 70518 201191 31425340
Actinic keratosis 30.50 10.65 42 70771 4137 31622394
Contusion 30.41 10.65 18 70795 33010 31593521
Hospitalisation 30.38 10.65 40 70773 49767 31576764
Granuloma 30.36 10.65 35 70778 2882 31623649
Splenomegaly 30.24 10.65 83 70730 13666 31612865
Accidental overdose 30.16 10.65 3 70810 18347 31608184
Unresponsive to stimuli 30.14 10.65 10 70803 25790 31600741
Herpes simplex 30.01 10.65 47 70766 5198 31621333
Cystitis escherichia 29.75 10.65 12 70801 159 31626372
Musculoskeletal discomfort 29.69 10.65 55 70758 6968 31619563
Disorientation 29.39 10.65 16 70797 30728 31595803
Red blood cell sedimentation rate abnormal 29.35 10.65 35 70778 2987 31623544
Gastrointestinal disorder 29.33 10.65 141 70672 30519 31596012
Heart rate decreased 29.25 10.65 133 70680 28133 31598398
Intestinal anastomosis 29.09 10.65 13 70800 225 31626306
White blood cell count decreased 29.08 10.65 99 70714 87299 31539232
Abdominal abscess 29.03 10.65 40 70773 3942 31622589
Angina pectoris 28.96 10.65 15 70798 29626 31596905
Gastrointestinal fistula 28.89 10.65 15 70798 366 31626165
Cow pox 28.45 10.65 8 70805 30 31626501
Ileostomy 28.19 10.65 17 70796 558 31625973
Complications of transplanted kidney 28.07 10.65 41 70772 4264 31622267
Enteritis 28.03 10.65 54 70759 7045 31619486
Scleroderma 27.93 10.65 24 70789 1383 31625148
Henoch-Schonlein purpura 27.68 10.65 25 70788 1540 31624991
Dysgeusia 27.58 10.65 9 70804 23457 31603074
Myopathy 27.43 10.65 69 70744 10783 31615748
Lung neoplasm 27.35 10.65 41 70772 4365 31622166
Acquired gene mutation 27.20 10.65 23 70790 1297 31625234
Body temperature fluctuation 27.16 10.65 25 70788 1578 31624953
Drug resistance 27.04 10.65 114 70699 23339 31603192
Herpes zoster meningoencephalitis 26.94 10.65 13 70800 270 31626261
Listeria sepsis 26.79 10.65 11 70802 153 31626378
Gastrointestinal lymphoma 26.77 10.65 8 70805 39 31626492
Gastrointestinal mucosa hyperaemia 26.77 10.65 13 70800 274 31626257
Insomnia 26.67 10.65 115 70698 94721 31531810
Cytokine release syndrome 26.64 10.65 3 70810 16639 31609892
Hypocalcaemia 26.60 10.65 8 70805 21970 31604561
Limb deformity 26.60 10.65 16 70797 523 31626008
Myasthenia gravis crisis 26.51 10.65 16 70797 526 31626005
Irritability 26.51 10.65 9 70804 22880 31603651
Pulmonary vasculitis 26.44 10.65 14 70799 356 31626175
Dyskinesia 26.44 10.65 7 70806 20903 31605628
Lupus nephritis 26.38 10.65 13 70800 283 31626248
Gait disturbance 26.31 10.65 87 70726 77408 31549123
Pouchitis 26.30 10.65 17 70796 632 31625899
C-reactive protein increased 25.99 10.65 192 70621 48458 31578073
Chronic gastrointestinal bleeding 25.97 10.65 13 70800 293 31626238
Liver transplant rejection 25.86 10.65 27 70786 1989 31624542
Suicide attempt 25.85 10.65 27 70786 37221 31589310
Pyrexia 25.73 10.65 873 69940 302967 31323564
Varicella 25.69 10.65 24 70789 1544 31624987
Hyperkalaemia 25.65 10.65 67 70746 64284 31562247
Congenital cytomegalovirus infection 25.61 10.65 7 70806 23 31626508
Papilloma viral infection 25.59 10.65 15 70798 467 31626064
Legionella infection 25.53 10.65 15 70798 469 31626062
Tonsil cancer 25.50 10.65 20 70793 1013 31625518
Fatigue 25.50 10.65 563 70250 334643 31291888
Nephropathy toxic 25.43 10.65 69 70744 11284 31615247
Eosinophilic bronchitis 25.40 10.65 11 70802 176 31626355
Transient ischaemic attack 25.31 10.65 11 70802 24045 31602486
Malignant melanoma 24.95 10.65 54 70759 7653 31618878
Metabolic acidosis 24.95 10.65 31 70782 39546 31586985
Drug tolerance decreased 24.86 10.65 25 70788 1762 31624769
Gastrointestinal stenosis 24.85 10.65 9 70804 87 31626444
Enterovesical fistula 24.80 10.65 17 70796 698 31625833
Myasthenic syndrome 24.78 10.65 14 70799 406 31626125
Arthropathy 24.76 10.65 113 70700 23938 31602593
Rhabdomyolysis 24.74 10.65 67 70746 63514 31563017
Proctitis 24.65 10.65 28 70785 2269 31624262
Bone erosion 24.54 10.65 34 70779 3369 31623162
Complications of transplanted lung 24.53 10.65 11 70802 192 31626339
Graft versus host disease in lung 24.51 10.65 15 70798 506 31626025
Coronary artery disease 24.24 10.65 41 70772 46046 31580485
Periumbilical abscess 24.22 10.65 8 70805 57 31626474
Mycobacterium chelonae infection 24.21 10.65 17 70796 726 31625805
Molluscum contagiosum 24.12 10.65 12 70801 267 31626264
Squamous cell carcinoma of the tongue 24.04 10.65 12 70801 269 31626262
Gastrointestinal wall thickening 24.02 10.65 22 70791 1380 31625151
Lymphocytic infiltration 24.00 10.65 16 70797 627 31625904
Mucosal inflammation 23.84 10.65 25 70788 34402 31592129
Angioedema 23.74 10.65 24 70789 33594 31592937
Stevens-Johnson syndrome 23.57 10.65 5 70808 17367 31609164
Plasmablastic lymphoma 23.29 10.65 12 70801 288 31626243
Lung abscess 23.17 10.65 28 70785 2423 31624108
Intestinal mass 23.07 10.65 14 70799 465 31626066
Eosinophilic granulomatosis with polyangiitis 23.02 10.65 23 70790 1608 31624923
Therapeutic reaction time decreased 23.00 10.65 18 70795 909 31625622
Osteonecrosis of jaw 22.99 10.65 5 70808 17066 31609465
Subdural haematoma 22.79 10.65 7 70806 18964 31607567
Arthritis 22.73 10.65 121 70692 27264 31599267
Growth retardation 22.43 10.65 23 70790 1659 31624872
Steroid dependence 22.39 10.65 14 70799 491 31626040
Uveitis 22.34 10.65 48 70765 6768 31619763
Product prescribing error 22.27 10.65 8 70805 19634 31606897
Autoimmune hepatitis 22.25 10.65 35 70778 3885 31622646
Phaeohyphomycosis 22.18 10.65 17 70796 832 31625699
Strongyloidiasis 22.15 10.65 28 70785 2538 31623993
Hepatosplenomegaly 22.10 10.65 35 70778 3908 31622623
Subcutaneous abscess 22.03 10.65 33 70780 3511 31623020
Listeria encephalitis 21.94 10.65 7 70806 44 31626487
Chest pain 21.92 10.65 162 70651 116795 31509736
Non-Hodgkin's lymphoma 21.85 10.65 22 70791 1553 31624978
Diffuse large B-cell lymphoma stage IV 21.81 10.65 12 70801 330 31626201
Loss of therapeutic response 21.69 10.65 13 70800 422 31626109
Hepatic enzyme increased 21.68 10.65 146 70667 35762 31590769
Limb discomfort 21.68 10.65 61 70752 10188 31616343
Small intestine adenocarcinoma 21.55 10.65 9 70804 131 31626400
Neutropenia 21.53 10.65 205 70608 140159 31486372
Narcotic bowel syndrome 21.49 10.65 9 70804 132 31626399
Epstein Barr virus positive mucocutaneous ulcer 21.46 10.65 12 70801 341 31626190
Cytomegalovirus chorioretinitis 21.42 10.65 32 70781 3396 31623135
Viral infection 21.36 10.65 80 70733 15513 31611018
Therapy non-responder 21.34 10.65 139 70674 33672 31592859
Amnesia 21.20 10.65 13 70800 23389 31603142
Intestinal anastomosis complication 21.19 10.65 9 70804 137 31626394
Brain abscess 21.14 10.65 29 70784 2846 31623685
Meningitis cryptococcal 21.09 10.65 26 70787 2297 31624234
Herpes simplex hepatitis 21.09 10.65 8 70805 89 31626442
Pyoderma gangrenosum 21.08 10.65 20 70793 1312 31625219
Odynophagia 20.98 10.65 39 70774 4954 31621577
Peritoneal abscess 20.93 10.65 8 70805 91 31626440
Congenital oesophageal anomaly 20.77 10.65 8 70805 93 31626438
Cutaneous leishmaniasis 20.71 10.65 10 70803 208 31626323
Butterfly rash 20.62 10.65 8 70805 95 31626436
Oesophageal atresia 20.56 10.65 13 70800 465 31626066
Hyperglycaemia 20.55 10.65 31 70782 36445 31590086
Liver disorder 20.53 10.65 125 70688 29582 31596949
Cardiac disorder 20.51 10.65 35 70778 39179 31587352
Intestinal ulcer 20.47 10.65 16 70797 806 31625725
Depression 20.45 10.65 119 70694 90696 31535835
Laryngeal mass 20.29 10.65 6 70807 28 31626503
Stiff person syndrome 20.25 10.65 8 70805 100 31626431
Congenital cystic lung 20.20 10.65 10 70803 220 31626311
Lactic acidosis 20.15 10.65 25 70788 31912 31594619
Aphthous ulcer 20.13 10.65 36 70777 4438 31622093
Anal stenosis 20.13 10.65 9 70804 156 31626375
Full blood count decreased 20.05 10.65 6 70807 16534 31609997
Injection site pain 19.93 10.65 29 70784 34605 31591926
Erectile dysfunction 19.91 10.65 9 70804 19226 31607305
Hepatotoxicity 19.79 10.65 90 70723 19036 31607495
Intentional product misuse 19.74 10.65 34 70779 37917 31588614
Haematuria 19.40 10.65 47 70766 46267 31580264
Autoimmune haemolytic anaemia 19.33 10.65 34 70779 4138 31622393
Paracoccidioides infection 19.20 10.65 7 70806 69 31626462
Ileal ulcer 19.13 10.65 13 70800 526 31626005
Dyspnoea exertional 19.11 10.65 36 70777 38801 31587730
Dry mouth 19 10.65 16 70797 24442 31602089
Gastrointestinal stoma complication 18.98 10.65 18 70795 1180 31625351
Mental status changes 18.91 10.65 32 70781 35936 31590595
Blood creatine phosphokinase increased 18.87 10.65 41 70772 41933 31584598
Splenic embolism 18.87 10.65 9 70804 182 31626349
Cytomegalovirus test positive 18.84 10.65 31 70782 3574 31622957
Skin lesion 18.82 10.65 90 70723 19437 31607094
Pulmonary granuloma 18.68 10.65 19 70794 1357 31625174
Drug interaction 18.59 10.65 341 70472 208202 31418329
Poor venous access 18.58 10.65 33 70780 4047 31622484
Autoimmune neutropenia 18.48 10.65 10 70803 266 31626265
Shoulder operation 18.47 10.65 16 70797 932 31625599
Gallbladder polyp 18.44 10.65 11 70802 354 31626177
Proctitis ulcerative 18.36 10.65 7 70806 79 31626452
Mucocutaneous leishmaniasis 18.36 10.65 7 70806 79 31626452
Haemolysis 18.36 10.65 46 70767 7170 31619361
Platelet count decreased 18.36 10.65 158 70655 110277 31516254
Psoriasis 18.34 10.65 49 70764 46670 31579861
Disturbance in attention 18.30 10.65 14 70799 22436 31604095
Ejection fraction decreased 18.29 10.65 8 70805 17426 31609105
Hypersensitivity vasculitis 18.26 10.65 29 70784 3246 31623285
Urinary tract infection 18.24 10.65 99 70714 76770 31549761
Acne 18.19 10.65 57 70756 10103 31616428
Pneumatosis intestinalis 18.18 10.65 31 70782 3680 31622851
Iron deficiency 18.13 10.65 29 70784 3265 31623266
Episcleritis 18.08 10.65 8 70805 135 31626396
Skin cancer 18.06 10.65 54 70759 9331 31617200
Osteoporosis 18.06 10.65 62 70751 11521 31615010
Herpes simplex test positive 18.02 10.65 9 70804 202 31626329
Chorioretinopathy 17.97 10.65 19 70794 1420 31625111
Retinal scar 17.95 10.65 10 70803 282 31626249
Drug ineffective for unapproved indication 17.88 10.65 83 70730 17707 31608824
Arrhythmia 17.78 10.65 29 70784 33048 31593483
Polyomavirus-associated nephropathy 17.74 10.65 30 70783 3538 31622993
Large intestinal ulcer 17.69 10.65 21 70792 1784 31624747
Anal cancer 17.64 10.65 11 70802 384 31626147
Hodgkin's disease 17.63 10.65 15 70798 853 31625678
Prostate cancer 17.52 10.65 36 70777 37565 31588966
Exposure to SARS-CoV-2 17.41 10.65 11 70802 393 31626138
Pseudopolyp 17.39 10.65 9 70804 218 31626313
Central nervous system lesion 17.37 10.65 40 70773 5908 31620623
Sleep disorder 17.28 10.65 20 70793 26328 31600203
Anaemia 17.24 10.65 355 70458 213167 31413364
Marrow hyperplasia 17.24 10.65 16 70797 1021 31625510
Sideroblastic anaemia 17.17 10.65 9 70804 224 31626307
Nausea 17.11 10.65 541 70272 307406 31319125
Immunosuppressant drug level increased 17.07 10.65 37 70776 5248 31621283
Pneumonia cytomegaloviral 16.99 10.65 26 70787 2818 31623713
Relapsing fever 16.94 10.65 8 70805 158 31626373
Extrapyramidal disorder 16.80 10.65 3 70810 11775 31614756
Laser therapy 16.77 10.65 4 70809 6 31626525
Cytomegalovirus duodenitis 16.66 10.65 6 70807 57 31626474
Ventricular tachycardia 16.64 10.65 17 70796 23684 31602847
Intestinal diaphragm disease 16.61 10.65 9 70804 240 31626291
Oesophagopleural fistula 16.56 10.65 6 70807 58 31626473
Optic neuritis 16.55 10.65 28 70785 3302 31623229
Cryptococcosis 16.32 10.65 23 70790 2315 31624216
Cytomegalovirus syndrome 16.28 10.65 7 70806 110 31626421
Pruritus 16.26 10.65 190 70623 124977 31501554
Prostatic specific antigen increased 16.25 10.65 5 70808 13533 31612998
Chronic myeloid leukaemia 16.16 10.65 25 70788 2736 31623795
Testicular cancer metastatic 16.12 10.65 6 70807 63 31626468
Aplasia pure red cell 16.12 10.65 38 70775 5699 31620832
Neoplasm progression 16.07 10.65 13 70800 20259 31606272
Hydrops foetalis 16.06 10.65 11 70802 451 31626080
Drug specific antibody absent 16.04 10.65 6 70807 64 31626467
Pancreatitis acute 16.00 10.65 105 70708 25495 31601036
Gastroenteritis clostridial 15.99 10.65 9 70804 259 31626272
Polyarteritis nodosa 15.93 10.65 9 70804 261 31626270
Serum sickness 15.91 10.65 20 70793 1802 31624729
Pneumoperitoneum 15.91 10.65 19 70794 1624 31624907
Dementia 15.89 10.65 4 70809 12356 31614175
Thrombocytopenia 15.84 10.65 224 70589 142523 31484008
Intentional self-injury 15.83 10.65 5 70808 13310 31613221
Asthma 15.76 10.65 46 70767 42565 31583966
Memory impairment 15.73 10.65 39 70774 38091 31588440
Gastric fistula 15.56 10.65 6 70807 70 31626461
Gastrointestinal obstruction 15.51 10.65 13 70800 724 31625807
Neurological symptom 15.50 10.65 29 70784 3702 31622829
Anorectal stenosis 15.44 10.65 4 70809 10 31626521
Cardiac myxoma 15.44 10.65 4 70809 10 31626521
Viral test positive 15.38 10.65 8 70805 196 31626335
Hypervolaemia 15.37 10.65 11 70802 18240 31608291
Posterior reversible encephalopathy syndrome 15.37 10.65 51 70762 9316 31617215
Vomiting 15.36 10.65 382 70431 223591 31402940
Sacroiliitis 15.33 10.65 17 70796 1341 31625190
Rash maculo-papular 15.33 10.65 21 70792 25698 31600833
Hyperhidrosis 15.33 10.65 88 70725 67305 31559226
Aqueductal stenosis 15.32 10.65 3 70810 0 31626531
Uveal melanoma 15.32 10.65 3 70810 0 31626531
Spermatozoa progressive motility decreased 15.27 10.65 7 70806 129 31626402
Diaphragmatic injury 15.27 10.65 7 70806 129 31626402
Epstein-Barr viraemia 15.26 10.65 15 70798 1028 31625503
Haematemesis 15.24 10.65 21 70792 25632 31600899
Cognitive disorder 15.21 10.65 20 70793 24903 31601628
Vitamin B1 decreased 15.19 10.65 9 70804 286 31626245
Urinary incontinence 15.17 10.65 10 70803 17310 31609221
Anorectal disorder 15.05 10.65 15 70798 1046 31625485
Fluid retention 15.04 10.65 20 70793 24782 31601749
Peripheral T-cell lymphoma unspecified stage IV 14.97 10.65 5 70808 37 31626494
Vision blurred 14.96 10.65 46 70767 41869 31584662
Schizophrenia 14.94 10.65 3 70810 10827 31615704
Diabetes mellitus 14.89 10.65 153 70660 42403 31584128
Toxic epidermal necrolysis 14.89 10.65 13 70800 19511 31607020
Disseminated cytomegaloviral infection 14.88 10.65 8 70805 210 31626321
Rectal discharge 14.84 10.65 8 70805 211 31626320
Functional gastrointestinal disorder 14.80 10.65 21 70792 2127 31624404
Aspiration 14.77 10.65 3 70810 10743 31615788
Cryptococcal cutaneous infection 14.71 10.65 6 70807 82 31626449
Hemivertebra 14.70 10.65 7 70806 141 31626390
Listeriosis 14.66 10.65 14 70799 926 31625605
Panniculitis 14.56 10.65 19 70794 1777 31624754
Coloboma 14.48 10.65 7 70806 146 31626385
Localised infection 14.45 10.65 70 70743 15195 31611336
Meconium peritonitis 14.44 10.65 4 70809 14 31626517
Herpes simplex colitis 14.44 10.65 4 70809 14 31626517
Campylobacter gastroenteritis 14.42 10.65 13 70800 799 31625732
Rectal cancer 14.41 10.65 21 70792 2180 31624351
Pulmonary oedema 14.39 10.65 51 70762 44451 31582080
Pain 14.34 10.65 313 70500 186446 31440085
Small intestinal resection 14.31 10.65 10 70803 424 31626107
Neuromyelitis optica spectrum disorder 14.26 10.65 7 70806 151 31626380
Haemorrhage intracranial 14.21 10.65 8 70805 15080 31611451
Tuberculosis gastrointestinal 14.19 10.65 8 70805 231 31626300
Hypoxia 14.14 10.65 61 70752 50252 31576279
Acute pulmonary histoplasmosis 14.06 10.65 7 70806 156 31626375
Haemophilus bacteraemia 14.02 10.65 4 70809 16 31626515
Pulmonary paracoccidioidomycosis 14.02 10.65 4 70809 16 31626515
Oropharyngeal pain 13.93 10.65 119 70694 31364 31595167
Jejunal stenosis 13.93 10.65 5 70808 47 31626484
Small intestinal ulcer haemorrhage 13.93 10.65 5 70808 47 31626484
Chronic graft versus host disease in intestine 13.88 10.65 8 70805 241 31626290
Infectious mononucleosis 13.86 10.65 11 70802 567 31625964
Hepatitis B 13.82 10.65 36 70777 5745 31620786
Acute respiratory failure 13.81 10.65 26 70787 28029 31598502
Pneumonia legionella 13.79 10.65 18 70795 1684 31624847
Respiratory tract infection fungal 13.78 10.65 12 70801 704 31625827
Gastrointestinal stoma output decreased 13.74 10.65 5 70808 49 31626482
General physical health deterioration 13.67 10.65 175 70638 113260 31513271
Unevaluable event 13.63 10.65 30 70783 30545 31595986
Neonatal respiratory failure 13.63 10.65 9 70804 347 31626184
Skin laceration 13.62 10.65 56 70757 11335 31615196
Lymph node tuberculosis 13.59 10.65 10 70803 460 31626071
Peritoneal candidiasis 13.30 10.65 4 70809 20 31626511
Mucous stools 13.30 10.65 16 70797 1378 31625153
Leiomyoma 13.25 10.65 3 70810 3 31626528
Hepatobiliary cancer 13.25 10.65 3 70810 3 31626528
Hepatic angiosarcoma 13.25 10.65 3 70810 3 31626528
Precursor T-lymphoblastic lymphoma/leukaemia stage I 13.25 10.65 3 70810 3 31626528
Cheilitis 13.21 10.65 20 70793 2148 31624383
Diabetic ketoacidosis 13.20 10.65 11 70802 16894 31609637
Rheumatoid arthritis 13.16 10.65 164 70649 47645 31578886
Olfactory nerve disorder 13.14 10.65 4 70809 21 31626510
Cytomegalovirus oesophagitis 13.13 10.65 10 70803 485 31626046
Muscle rigidity 13.12 10.65 3 70810 9894 31616637
Skin papilloma 13.02 10.65 18 70795 1779 31624752
Restlessness 13.01 10.65 20 70793 23341 31603190
Dysarthria 13.01 10.65 33 70780 31984 31594547
Fear of injection 13 10.65 15 70798 1236 31625295
Necrotising herpetic retinopathy 12.99 10.65 4 70809 22 31626509
Drug specific antibody 12.91 10.65 8 70805 276 31626255
Withdrawal syndrome 12.90 10.65 5 70808 11712 31614819
Pulmonary nocardiosis 12.89 10.65 11 70802 628 31625903
Diarrhoea 12.87 10.65 650 70163 351759 31274772
Polydipsia 12.86 10.65 26 70787 3514 31623017
Brachycephaly 12.84 10.65 5 70808 60 31626471
Overgrowth bacterial 12.82 10.65 6 70807 116 31626415
Metastases to lymph nodes 12.80 10.65 29 70784 4239 31622292
Microscopic polyangiitis 12.77 10.65 7 70806 191 31626340
Dysphagia 12.75 10.65 76 70737 57600 31568931
Adverse drug reaction 12.72 10.65 23 70790 25178 31601353
Aspartate aminotransferase increased 12.65 10.65 85 70728 62634 31563897
Oropharyngeal squamous cell carcinoma 12.64 10.65 7 70806 195 31626336
Gastrointestinal scarring 12.64 10.65 6 70807 120 31626411
Lip swelling 12.64 10.65 7 70806 13316 31613215
Epstein-Barr virus antibody positive 12.63 10.65 8 70805 287 31626244
Neoplasm skin 12.61 10.65 11 70802 647 31625884
Fluctuance 12.56 10.65 4 70809 25 31626506
Antibody test abnormal 12.51 10.65 7 70806 199 31626332
Accidental exposure to product 12.50 10.65 5 70808 11490 31615041
Psychotic disorder 12.50 10.65 19 70794 22274 31604257
Colonoscopy abnormal 12.48 10.65 5 70808 65 31626466
Red blood cell sedimentation rate increased 12.43 10.65 44 70769 8302 31618229
Drain placement 12.35 10.65 5 70808 67 31626464
Placental disorder 12.35 10.65 5 70808 67 31626464
Gastrointestinal oedema 12.30 10.65 15 70798 1310 31625221
Suicidal ideation 12.26 10.65 41 70772 36365 31590166
Skin hyperpigmentation 12.22 10.65 23 70790 2948 31623583
Glycosylated haemoglobin increased 12.20 10.65 4 70809 10396 31616135
Pseudolymphoma 12.15 10.65 10 70803 543 31625988
Lymphocyte count 12.15 10.65 5 70808 70 31626461
Ischaemic stroke 12.11 10.65 12 70801 16959 31609572
Anaplastic large cell lymphoma T- and null-cell types 12.08 10.65 6 70807 133 31626398
Mycobacterium kansasii infection 12.06 10.65 8 70805 311 31626220
Anaplastic large cell lymphoma T- and null-cell types stage III 12.04 10.65 3 70810 6 31626525
Actinic cheilitis 12.04 10.65 3 70810 6 31626525
Caesarean section 11.99 10.65 18 70795 1918 31624613
Disseminated cryptococcosis 11.99 10.65 15 70798 1345 31625186
Angina unstable 11.96 10.65 5 70808 11190 31615341
Hiccups 11.95 10.65 3 70810 9284 31617247
Blood sodium decreased 11.92 10.65 10 70803 15305 31611226
Cryptosporidiosis infection 11.91 10.65 9 70804 431 31626100
Skin ulcer 11.91 10.65 81 70732 19904 31606627
Anger 11.89 10.65 5 70808 11148 31615383
Appendicectomy 11.88 10.65 12 70801 850 31625681
Colonic abscess 11.88 10.65 9 70804 433 31626098
Alanine aminotransferase increased 11.88 10.65 108 70705 74548 31551983
Human ehrlichiosis 11.85 10.65 7 70806 221 31626310
Antiphospholipid syndrome 11.82 10.65 9 70804 436 31626095
Hepatitis cholestatic 11.80 10.65 39 70774 7107 31619424
Scar 11.78 10.65 33 70780 5497 31621034
Drug level abnormal 11.76 10.65 6 70807 141 31626390
Altered state of consciousness 11.75 10.65 18 70795 21033 31605498
Acute haemorrhagic ulcerative colitis 11.72 10.65 3 70810 7 31626524
B-cell lymphoma stage IV 11.72 10.65 5 70808 77 31626454
Gastrointestinal cancer metastatic 11.72 10.65 5 70808 77 31626454
Diffuse large B-cell lymphoma stage III 11.72 10.65 5 70808 77 31626454
Brain stem syndrome 11.66 10.65 9 70804 445 31626086
Myelitis transverse 11.64 10.65 13 70800 1034 31625497
Ventricular fibrillation 11.63 10.65 15 70798 18833 31607698
Polychondritis 11.63 10.65 7 70806 229 31626302
Adenocarcinoma 11.60 10.65 17 70796 1774 31624757
Therapy cessation 11.51 10.65 10 70803 15045 31611486
Autoscopy 11.50 10.65 6 70807 148 31626383
Alternaria infection 11.47 10.65 8 70805 338 31626193
Hallucination, visual 11.47 10.65 11 70802 15783 31610748
Death neonatal 11.41 10.65 8 70805 341 31626190
Blood bilirubin decreased 11.41 10.65 8 70805 341 31626190
Pneumocystis jirovecii infection 11.39 10.65 16 70797 1606 31624925
Short-bowel syndrome 11.36 10.65 7 70806 239 31626292
Mycobacterium abscessus infection 11.32 10.65 10 70803 598 31625933
Small intestine carcinoma 11.32 10.65 10 70803 598 31625933
Osteonecrosis 11.28 10.65 61 70752 13823 31612708
Eosinophilic myocarditis 11.27 10.65 9 70804 468 31626063
Anastomotic fistula 11.22 10.65 5 70808 86 31626445
Chromaturia 11.22 10.65 8 70805 13290 31613241
Leiomyosarcoma 11.14 10.65 6 70807 158 31626373
Oedema 11.12 10.65 53 70760 42508 31584023
Contraindicated product administered 11.11 10.65 79 70734 19693 31606838
Oesophagitis 11.10 10.65 7 70806 12409 31614122
Myoclonus 11.05 10.65 9 70804 13981 31612550
Chronic graft versus host disease in liver 11.04 10.65 8 70805 359 31626172
Nail pitting 11.03 10.65 7 70806 252 31626279
Peritoneal tuberculosis 11.03 10.65 8 70805 360 31626171
Foetal cardiac disorder 10.94 10.65 3 70810 10 31626521
Mediastinum neoplasm 10.94 10.65 3 70810 10 31626521
Perineal fistula 10.94 10.65 3 70810 10 31626521
Hodgkin's disease nodular sclerosis 10.94 10.65 3 70810 10 31626521
Haemodialysis 10.94 10.65 48 70765 9997 31616534
Diaphragmatic hernia 10.93 10.65 7 70806 256 31626275
Atrial flutter 10.88 10.65 10 70803 14645 31611886
Scleritis 10.88 10.65 9 70804 492 31626039
Xanthoma 10.86 10.65 5 70808 93 31626438
American trypanosomiasis 10.86 10.65 7 70806 259 31626272
Injury 10.86 10.65 17 70796 19692 31606839
Tumour lysis syndrome 10.84 10.65 11 70802 15374 31611157
Hypocalvaria 10.84 10.65 4 70809 41 31626490
Paranoia 10.83 10.65 5 70808 10550 31615981
Cardiogenic shock 10.82 10.65 21 70792 22387 31604144
Inappropriate antidiuretic hormone secretion 10.77 10.65 6 70807 11381 31615150
Smooth muscle cell neoplasm 10.75 10.65 6 70807 170 31626361
Complications of transplanted heart 10.74 10.65 7 70806 264 31626267
Haemoglobin decreased 10.73 10.65 182 70631 112493 31514038
Rectal stenosis 10.71 10.65 6 70807 171 31626360
Hepatitis chronic active 10.67 10.65 4 70809 43 31626488
Lymphadenopathy 10.66 10.65 97 70716 26024 31600507

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Off label use 1072.44 9.74 4002 163141 739058 70022243
Colitis ulcerative 988.03 9.74 740 166403 33183 70728118
Drug ineffective 715.37 9.74 4201 162942 935551 69825750
Completed suicide 490.31 9.74 9 167134 227126 70534175
Condition aggravated 426.16 9.74 2063 165080 425572 70335729
Death 412.50 9.74 358 166785 509703 70251598
Treatment failure 404.62 9.74 985 166158 143157 70618144
Intentional product use issue 388.60 9.74 868 166275 119274 70642027
Post transplant lymphoproliferative disorder 382.52 9.74 263 166880 10282 70751019
Exposure during pregnancy 364.96 9.74 703 166440 87014 70674287
Cytomegalovirus infection 358.12 9.74 455 166688 39303 70721998
Fall 323.51 9.74 342 166801 443754 70317547
Intestinal stenosis 316.67 9.74 156 166987 3211 70758090
Epstein-Barr virus infection 302.30 9.74 250 166893 12948 70748353
Drug level below therapeutic 284.83 9.74 204 166939 8519 70752782
Drug abuse 282.11 9.74 16 167127 147240 70614061
Product use in unapproved indication 280.37 9.74 1098 166045 206380 70554921
Toxicity to various agents 271.89 9.74 300 166843 381872 70379429
Hepatosplenic T-cell lymphoma 270.05 9.74 97 167046 861 70760440
Inappropriate schedule of product administration 268.24 9.74 703 166440 106852 70654449
Product use issue 265.12 9.74 979 166164 178958 70582343
Cushingoid 239.67 9.74 181 166962 8207 70753094
Disease recurrence 237.72 9.74 363 166780 37240 70724061
Fistula 234.50 9.74 199 166944 10682 70750619
Nodular regenerative hyperplasia 231.41 9.74 94 167049 1199 70760102
Frequent bowel movements 231.09 9.74 267 166876 20886 70740415
Hypotension 228.27 9.74 376 166767 404005 70357296
Faecal calprotectin increased 220.07 9.74 135 167008 4330 70756971
Diffuse large B-cell lymphoma 213.29 9.74 206 166937 13096 70748205
Anal abscess 211.88 9.74 168 166975 8190 70753111
Premature delivery 211.38 9.74 256 166887 21048 70740253
Anal fistula 207.96 9.74 146 166997 5904 70755397
Drug intolerance 205.83 9.74 1063 166080 224624 70536677
Maternal exposure during pregnancy 200.45 9.74 663 166480 114682 70646619
Bone erosion 199.41 9.74 211 166932 14962 70746339
Lupus-like syndrome 199.25 9.74 186 166957 11329 70749972
Febrile neutropenia 195.14 9.74 120 167023 204198 70557103
Drug eruption 192.45 9.74 339 166804 39157 70722144
Haemophagocytic lymphohistiocytosis 187.02 9.74 231 166912 19381 70741920
Lymphoproliferative disorder 186.43 9.74 130 167013 5199 70756102
Confusional state 183.25 9.74 241 166902 284157 70477144
Ileal stenosis 182.67 9.74 93 167050 2058 70759243
Malignant neoplasm progression 180.56 9.74 34 167109 121705 70639596
Therapeutic product effect incomplete 176.22 9.74 652 166491 119230 70642071
Atrial fibrillation 175.02 9.74 109 167034 184239 70577062
Transplant rejection 173.23 9.74 214 166929 17957 70743344
Hyponatraemia 171.89 9.74 81 167062 160006 70601295
Basal cell carcinoma 162.58 9.74 288 166855 33410 70727891
Disseminated tuberculosis 162.40 9.74 108 167035 3992 70757309
Epstein-Barr virus associated lymphoproliferative disorder 160.96 9.74 99 167044 3190 70758111
SLE arthritis 160.79 9.74 57 167086 485 70760816
Therapeutic response decreased 160.13 9.74 396 166747 58057 70703244
Kidney transplant rejection 157.33 9.74 153 166990 9808 70751493
Somnolence 156.73 9.74 166 166977 215440 70545861
Blood pressure fluctuation 154.54 9.74 393 166750 58619 70702682
Drug level decreased 154.38 9.74 169 166974 12455 70748846
Squamous cell carcinoma 153.94 9.74 181 166962 14423 70746878
Therapeutic product effect decreased 152.01 9.74 704 166439 142314 70618987
Red blood cell sedimentation rate increased 151.26 9.74 302 166841 38340 70722961
Crohn's disease 150.48 9.74 87 167056 2497 70758804
Cytomegalovirus colitis 142.97 9.74 101 167042 4125 70757176
Cardiac failure congestive 141.67 9.74 71 167072 135386 70625915
Vasculitis 141.18 9.74 201 166942 19357 70741944
C-reactive protein increased 138.77 9.74 572 166571 109945 70651356
Progressive multifocal leukoencephalopathy 138.01 9.74 197 166946 19017 70742284
Overdose 135.76 9.74 120 167023 169625 70591676
Pneumocystis jirovecii pneumonia 134.81 9.74 249 166894 29833 70731468
Pancytopenia 132.99 9.74 705 166438 150402 70610899
Abscess 132.80 9.74 201 166942 20453 70740848
Intestinal obstruction 132.72 9.74 287 166856 38538 70722763
Arthritis 131.70 9.74 518 166625 97462 70663839
Acute kidney injury 131.64 9.74 623 166520 474001 70287300
Large intestinal stenosis 130.17 9.74 79 167064 2484 70758817
Haematochezia 129.52 9.74 423 166720 72658 70688643
Dyspnoea 129.33 9.74 1177 165966 768883 69992418
Intestinal resection 127.77 9.74 86 167057 3244 70758057
Cholestasis of pregnancy 125.47 9.74 56 167087 913 70760388
Syncope 124.46 9.74 124 167019 165585 70595716
Cardio-respiratory arrest 124.38 9.74 41 167102 100636 70660665
Hypokalaemia 123.89 9.74 78 167065 131110 70630191
Cytomegalovirus viraemia 123.46 9.74 145 166998 11540 70749761
Lupus nephritis 122.36 9.74 79 167064 2775 70758526
Bradycardia 122.00 9.74 71 167072 124544 70636757
Demyelination 121.58 9.74 115 167028 7121 70754180
Anal fissure 118.21 9.74 106 167037 6127 70755174
Lung transplant rejection 115.26 9.74 59 167084 1321 70759980
Electrocardiogram QT prolonged 114.29 9.74 28 167115 83489 70677812
Scleritis 112.08 9.74 82 167061 3540 70757761
Intentional overdose 111.64 9.74 46 167097 98389 70662912
Drug specific antibody present 111.34 9.74 99 167044 5659 70755642
Leukopenia 111.32 9.74 522 166621 106038 70655263
Dizziness 110.86 9.74 641 166502 463500 70297801
Loss of consciousness 108.59 9.74 124 167019 155592 70605709
Cardiac arrest 108.54 9.74 130 167013 159704 70601597
Abdominal pain 108.10 9.74 1257 165886 340870 70420431
Clostridium difficile infection 106.32 9.74 263 166880 38553 70722748
Therapeutic response shortened 106.31 9.74 141 167002 12697 70748604
B-cell lymphoma 106.03 9.74 100 167043 6169 70755132
Pulmonary tuberculosis 104.69 9.74 110 167033 7735 70753566
Elbow deformity 103.75 9.74 56 167087 1402 70759899
Colectomy 101.95 9.74 71 167072 2833 70758468
Product dose omission issue 101.69 9.74 226 166917 217242 70544059
Diarrhoea haemorrhagic 100.49 9.74 131 167012 11599 70749702
Neutrophil count decreased 99.81 9.74 36 167107 83520 70677781
Premature labour 99.39 9.74 108 167035 7892 70753409
Hypoglycaemia 99.35 9.74 49 167094 94315 70666986
Blood iron abnormal 99.02 9.74 51 167092 1157 70760144
Erythema nodosum 98.71 9.74 83 167060 4398 70756903
Inflammation 97.82 9.74 406 166737 78259 70683042
Retinitis 97.76 9.74 80 167063 4080 70757221
Arthralgia 97.32 9.74 1696 165447 501694 70259607
Osteoporosis 95.74 9.74 293 166850 48614 70712687
Proteinuria 95.70 9.74 213 166930 29161 70732140
Rheumatoid arthritis 94.77 9.74 1078 166065 290727 70470574
Coma 94.73 9.74 49 167094 91795 70669506
Myocardial infarction 94.43 9.74 162 166981 171483 70589818
Histoplasmosis disseminated 93.02 9.74 59 167084 2009 70759292
Sedation 92.89 9.74 4 167139 46727 70714574
Granulomatosis with polyangiitis 92.25 9.74 64 167079 2538 70758763
Cerebrovascular accident 91.88 9.74 122 167021 143348 70617953
Clear cell renal cell carcinoma 91.86 9.74 61 167082 2249 70759052
Intestinal fistula 91.66 9.74 50 167093 1279 70760022
Antinuclear antibody positive 91.52 9.74 96 167047 6737 70754564
Epstein-Barr virus test positive 91.21 9.74 46 167097 997 70760304
Asthenia 91.01 9.74 668 166475 456998 70304303
Constipation 89.08 9.74 301 166842 252137 70509164
Plasma cell myeloma 88.35 9.74 31 167112 73170 70688131
Contusion 87.06 9.74 104 167039 127932 70633369
Tuberculosis 86.39 9.74 138 167005 14710 70746591
Kaposi's sarcoma 85.74 9.74 40 167103 726 70760575
Weight decreased 85.58 9.74 1112 166031 309376 70451925
Acute febrile neutrophilic dermatosis 85.50 9.74 69 167074 3450 70757851
Normal newborn 85.25 9.74 89 167054 6211 70755090
JC virus infection 84.95 9.74 69 167074 3482 70757819
Fatigue 84.56 9.74 1401 165742 822918 69938383
Joint dislocation 84.47 9.74 135 167008 14396 70746905
Dehydration 83.69 9.74 264 166879 225878 70535423
Aphthous ulcer 83.61 9.74 135 167008 14521 70746780
Rheumatoid nodule 83.53 9.74 137 167006 14930 70746371
Pre-eclampsia 83.11 9.74 89 167054 6396 70754905
Epidermodysplasia verruciformis 83.04 9.74 27 167116 171 70761130
Colitis 83.01 9.74 334 166809 63480 70697821
Hepatic cirrhosis 82.88 9.74 207 166936 30524 70730777
Depressed level of consciousness 82.51 9.74 52 167091 87379 70673922
Nocardiosis 81.41 9.74 79 167064 5050 70756251
Abortion spontaneous 80.69 9.74 187 166956 26292 70735009
Drug tolerance decreased 79.89 9.74 107 167036 9726 70751575
Histoplasmosis 79.38 9.74 54 167089 2073 70759228
Squamous cell carcinoma of skin 79.31 9.74 122 167021 12590 70748711
Chronic allograft nephropathy 78.50 9.74 48 167095 1530 70759771
Drug level above therapeutic 78.37 9.74 94 167049 7648 70753653
Respiratory arrest 77.97 9.74 16 167127 53917 70707384
Immunosuppression 76.96 9.74 114 167029 11378 70749923
Autoimmune hepatitis 76.59 9.74 110 167033 10676 70750625
Mycobacterial infection 75.58 9.74 64 167079 3424 70757877
Orthostatic hypotension 75.54 9.74 15 167128 51728 70709573
Blood glucose increased 75.10 9.74 79 167064 102903 70658398
Agitation 74.64 9.74 66 167077 93309 70667992
Insomnia 74.60 9.74 263 166880 217543 70543758
Decreased appetite 74.23 9.74 418 166725 304362 70456939
Platelet count decreased 74 9.74 197 166946 178025 70583276
Hepatic function abnormal 73.87 9.74 337 166806 67659 70693642
Gastrointestinal inflammation 73.65 9.74 85 167058 6638 70754663
Chronic obstructive pulmonary disease 73.51 9.74 46 167097 77595 70683706
Impaired gastric emptying 72.35 9.74 100 167043 9366 70751935
Exostosis 72.30 9.74 125 167018 14220 70747081
Hyperkalaemia 72.02 9.74 87 167056 106504 70654797
Seizure 71.43 9.74 200 166943 177762 70583539
Gastrointestinal lymphoma 71.10 9.74 23 167120 143 70761158
Synovial fluid analysis 71.06 9.74 48 167095 1821 70759480
Balance disorder 70.49 9.74 65 167078 90063 70671238
Tenosynovitis stenosans 70.34 9.74 52 167091 2281 70759020
Hallucination 69.72 9.74 47 167096 76213 70685088
Cardiac failure 69.70 9.74 146 166997 143395 70617906
Myasthenia gravis 69.25 9.74 86 167057 7253 70754048
Ulcer 68.95 9.74 173 166970 25581 70735720
Hair follicle tumour benign 68.58 9.74 29 167114 412 70760889
T-cell lymphoma 68.08 9.74 41 167102 1271 70760030
Aspergillus infection 67.95 9.74 138 167005 17730 70743571
Inflammatory bowel disease 67.77 9.74 71 167072 4975 70756326
Pneumonia aspiration 67.62 9.74 31 167112 62258 70699043
Heart transplant rejection 67.39 9.74 41 167102 1295 70760006
Coombs positive haemolytic anaemia 66.85 9.74 36 167107 897 70760404
Human herpesvirus 8 infection 66.66 9.74 38 167105 1061 70760240
Serotonin syndrome 66.32 9.74 10 167133 42104 70719197
Pain 66.24 9.74 1063 166080 627753 70133548
Tremor 66.14 9.74 170 166973 155454 70605847
Wrong technique in product usage process 66.01 9.74 40 167103 68658 70692643
Panniculitis 65.96 9.74 102 167041 10574 70750727
Lactic acidosis 65.13 9.74 36 167107 64988 70696313
Small intestinal stenosis 65.11 9.74 32 167111 655 70760646
Neuropathy peripheral 65.09 9.74 125 167018 126771 70634530
Epstein-Barr virus associated lymphoma 64.46 9.74 37 167106 1047 70760254
Depression 64.36 9.74 246 166897 198728 70562573
Renal cell carcinoma 64.16 9.74 82 167061 7119 70754182
Gastrointestinal haemorrhage 64.03 9.74 143 167000 137265 70624036
Gestational hypertension 63.17 9.74 44 167099 1756 70759545
Acute myocardial infarction 62.61 9.74 48 167095 72839 70688462
Suicide attempt 62.59 9.74 57 167086 79453 70681848
Lymphopenia 62.27 9.74 173 166970 27186 70734115
Extrapulmonary tuberculosis 62.02 9.74 26 167117 361 70760940
Metabolic acidosis 61.30 9.74 51 167092 74295 70687006
Defaecation urgency 60.53 9.74 64 167079 4533 70756768
Bone marrow failure 59.39 9.74 251 166892 48759 70712542
Delirium 59.32 9.74 53 167090 74561 70686740
Intentional product misuse 59.23 9.74 60 167083 79535 70681766
Papilloma viral infection 59.04 9.74 40 167103 1525 70759776
Varicella zoster virus infection 59.00 9.74 60 167083 4060 70757241
Neuromyelitis optica spectrum disorder 58.99 9.74 35 167108 1055 70760246
Anxiety 58.73 9.74 293 166850 220037 70541264
Cholangitis sclerosing 58.10 9.74 46 167097 2237 70759064
Unresponsive to stimuli 57.70 9.74 25 167118 51906 70709395
International normalised ratio increased 57.66 9.74 63 167080 80663 70680638
Hypogammaglobulinaemia 57.44 9.74 100 167043 11438 70749863
Immunosuppressant drug level decreased 57.30 9.74 42 167101 1818 70759483
Urinary retention 57.23 9.74 26 167117 52494 70708807
Episcleritis 56.64 9.74 33 167110 961 70760340
Joint stiffness 56.47 9.74 197 166946 34979 70726322
Myasthenia gravis crisis 56.43 9.74 33 167110 968 70760333
Central nervous system lymphoma 56.28 9.74 45 167098 2220 70759081
Listeriosis 56.18 9.74 43 167100 1989 70759312
Hypersensitivity 55.87 9.74 805 166338 229007 70532294
Palmar-plantar erythrodysaesthesia syndrome 55.77 9.74 4 167139 30243 70731058
Dyskinesia 55.74 9.74 14 167129 41060 70720241
Diabetes mellitus 55.71 9.74 324 166819 71500 70689801
Angiocentric lymphoma 55.26 9.74 32 167111 921 70760380
Drug hypersensitivity 54.09 9.74 894 166249 261565 70499736
Immunosuppressant drug level increased 53.76 9.74 79 167064 7828 70753473
Intentional self-injury 53.48 9.74 6 167137 31644 70729657
Foot deformity 53.47 9.74 137 167006 20518 70740783
Fistula discharge 52.57 9.74 33 167110 1103 70760198
Injection site swelling 52.55 9.74 18 167125 43139 70718162
Heart rate irregular 52.53 9.74 172 166971 29571 70731730
Infusion related reaction 52.48 9.74 703 166440 196831 70564470
Oedema peripheral 52.21 9.74 319 166824 227772 70533529
Uveitis 52.17 9.74 111 167032 14734 70746567
Lupus vasculitis 51.80 9.74 25 167118 491 70760810
Body temperature fluctuation 51.27 9.74 52 167091 3507 70757794
Plasmablastic lymphoma 51.20 9.74 26 167117 572 70760729
Live birth 50.72 9.74 105 167038 13674 70747627
Vomiting 50.65 9.74 1040 166103 592071 70169230
Muscle injury 50.57 9.74 14 167129 38480 70722821
Back pain 49.93 9.74 404 166739 270748 70490553
Injection site erythema 49.81 9.74 59 167084 72865 70688436
Skin ulcer 49.62 9.74 235 166908 47910 70713391
Accidental overdose 49.58 9.74 11 167132 35110 70726191
Pulmonary fibrosis 49.02 9.74 185 166958 34125 70727176
Therapeutic reaction time decreased 48.92 9.74 44 167099 2553 70758748
Pneumonia cytomegaloviral 48.85 9.74 57 167086 4504 70756797
Portal hypertension 48.75 9.74 68 167075 6424 70754877
Cytomegalovirus enteritis 48.58 9.74 27 167116 717 70760584
Rebound effect 48.55 9.74 65 167078 5906 70755395
Transplant dysfunction 48.38 9.74 70 167073 6839 70754462
Hyperhidrosis 48.37 9.74 154 166989 131432 70629869
Medication error 48.22 9.74 38 167105 56874 70704427
Liver transplant rejection 48.16 9.74 47 167096 3025 70758276
Type 2 lepra reaction 48.09 9.74 22 167121 381 70760920
Rheumatoid factor negative 47.96 9.74 31 167112 1091 70760210
Sopor 47.93 9.74 8 167135 31259 70730042
Suicidal ideation 47.86 9.74 56 167087 69540 70691761
Rectal abscess 47.61 9.74 36 167107 1635 70759666
Non-cirrhotic portal hypertension 47.57 9.74 22 167121 391 70760910
Pyoderma gangrenosum 47.36 9.74 51 167092 3688 70757613
Peliosis hepatis 47.25 9.74 15 167128 87 70761214
Actinic keratosis 47.22 9.74 62 167081 5528 70755773
White blood cell count decreased 47.21 9.74 223 166920 169918 70591383
Enterocutaneous fistula 47.09 9.74 36 167107 1662 70759639
Lymphoma 46.89 9.74 109 167034 15353 70745948
Aggression 46.83 9.74 28 167115 48418 70712883
Abnormal behaviour 46.78 9.74 12 167131 34697 70726604
Pleuritic pain 46.77 9.74 79 167064 8818 70752483
Chorioretinopathy 46.53 9.74 40 167103 2185 70759116
Hepatosplenomegaly 46.52 9.74 62 167081 5608 70755693
Abscess intestinal 46.42 9.74 42 167101 2456 70758845
Disorientation 46.21 9.74 41 167102 57882 70703419
Injection site pain 45.84 9.74 134 167009 117485 70643816
Small intestinal obstruction 45.74 9.74 145 166998 24510 70736791
Disseminated cytomegaloviral infection 45.64 9.74 22 167121 431 70760870
Nausea 45.31 9.74 1599 165544 850489 69910812
Ileostomy 45.05 9.74 33 167110 1427 70759874
Varicella 44.90 9.74 43 167100 2704 70758597
Hypocalcaemia 44.68 9.74 25 167118 44834 70716467
Musculoskeletal stiffness 44.38 9.74 538 166605 147222 70614079
Proctocolectomy 44.35 9.74 16 167127 144 70761157
Neutropenia 44.25 9.74 390 166753 256766 70504535
Premature rupture of membranes 43.91 9.74 50 167093 3848 70757453
Subcutaneous abscess 43.90 9.74 69 167074 7253 70754048
Systemic lupus erythematosus 43.81 9.74 399 166744 101503 70659798
Abdominal abscess 43.68 9.74 65 167078 6513 70754788
Immunoglobulin G4 related disease 43.59 9.74 18 167125 240 70761061
Anaemia 43.38 9.74 679 166464 402744 70358557
Meningitis listeria 43.27 9.74 27 167116 893 70760408
Intestinal anastomosis 43.15 9.74 23 167120 561 70760740
Mucosal inflammation 43.11 9.74 58 167085 67792 70693509
Pancreatitis 43.08 9.74 274 166869 62394 70698907
Abdominal adhesions 42.93 9.74 45 167098 3155 70758146
Joint swelling 42.79 9.74 836 166307 252375 70508926
Granuloma skin 42.78 9.74 70 167073 7612 70753689
Strongyloidiasis 42.35 9.74 48 167095 3675 70757626
Herpes zoster 42.01 9.74 344 166799 84891 70676410
Fungal endocarditis 41.98 9.74 22 167121 518 70760783
Drug ineffective for unapproved indication 41.84 9.74 191 166952 38347 70722954
Anti-neutrophil cytoplasmic antibody positive vasculitis 41.82 9.74 45 167098 3252 70758049
Pneumatosis intestinalis 41.74 9.74 60 167083 5827 70755474
Complications of transplanted kidney 41.38 9.74 60 167083 5874 70755427
Asthma 41.23 9.74 146 166997 120647 70640654
Neoplasm progression 41.17 9.74 28 167115 45200 70716101
Herpes simplex hepatitis 41.11 9.74 21 167122 468 70760833
Mental status changes 41.05 9.74 53 167090 63048 70698253
Cognitive disorder 40.90 9.74 50 167093 60906 70700395
Ankylosing spondylitis 40.83 9.74 87 167056 11559 70749742
Contraindicated product administered 40.81 9.74 491 166652 134121 70627180
Poor venous access 40.53 9.74 101 167042 14870 70746431
Synovitis 40.33 9.74 474 166669 128754 70632547
Granuloma 40.02 9.74 68 167075 7627 70753674
Red blood cell sedimentation rate abnormal 39.99 9.74 118 167025 19185 70742116
Restlessness 39.82 9.74 25 167118 42103 70719198
Candida infection 39.80 9.74 174 166969 34299 70727002
Blister 39.56 9.74 114 167029 100412 70660889
Blood parathyroid hormone decreased 39.55 9.74 74 167069 8950 70752351
C-reactive protein abnormal 39.53 9.74 188 166955 38391 70722910
Coronary artery disease 39.48 9.74 54 167089 62682 70698619
Aplasia pure red cell 39.46 9.74 66 167077 7308 70753993
Fluid retention 39.45 9.74 55 167088 63330 70697971
Mycobacterium abscessus infection 39.41 9.74 29 167114 1263 70760038
Hyperglycaemia 39.37 9.74 57 167086 64615 70696686
Brain abscess 39.12 9.74 51 167092 4515 70756786
Intestinal perforation 39.06 9.74 104 167039 15940 70745361
Poisoning 38.96 9.74 4 167139 22618 70738683
Hypomagnesaemia 38.79 9.74 24 167119 40740 70720561
Caesarean section 38.74 9.74 85 167058 11522 70749779
Swelling 38.43 9.74 273 166870 188266 70573035
Rheumatoid lung 38.34 9.74 44 167099 3415 70757886
Epicondylitis 38.26 9.74 34 167109 1942 70759359
Osteonecrosis 38.21 9.74 153 166990 29007 70732294
Obliterative bronchiolitis 38.01 9.74 40 167103 2817 70758484
Myopathy 37.82 9.74 113 167030 18499 70742802
Pulmonary mass 37.71 9.74 141 167002 25892 70735409
Pulmonary oedema 37.20 9.74 87 167056 82191 70679110
Lung abscess 37.15 9.74 45 167098 3699 70757602
Bone pain 37.03 9.74 39 167104 50783 70710518
Blood calcium decreased 36.95 9.74 11 167132 28835 70732466
Laryngitis 36.94 9.74 92 167051 13539 70747762
Full blood count decreased 36.93 9.74 6 167137 23912 70737389
Angina pectoris 36.53 9.74 36 167107 48347 70712954
Tenosynovitis 36.49 9.74 93 167050 13883 70747418
Vision blurred 36.44 9.74 109 167034 94875 70666426
Duodenal ulcer perforation 36.37 9.74 40 167103 51072 70710229
Cutaneous T-cell lymphoma 36.23 9.74 37 167106 2516 70758785
Dysgeusia 36.05 9.74 38 167105 49464 70711837
Impaired work ability 35.88 9.74 102 167041 16238 70745063
Pneumocystis jirovecii infection 35.74 9.74 37 167106 2557 70758744
Visceral leishmaniasis 35.62 9.74 25 167118 1010 70760291
Cardiac disorder 35.55 9.74 53 167090 59362 70701939
Neuroendocrine carcinoma of the skin 35.46 9.74 26 167117 1126 70760175
Legionella infection 35.08 9.74 22 167121 734 70760567
Overlap syndrome 34.66 9.74 22 167121 750 70760551
Hypervolaemia 34.29 9.74 26 167117 39680 70721621
Thrombocytopenia 34.27 9.74 379 166764 238731 70522570
Steroid dependence 34.21 9.74 21 167122 674 70760627
Skin lesion 34.16 9.74 180 166963 38280 70723021
Eosinophilic granulomatosis with polyangiitis 34.15 9.74 40 167103 3173 70758128
Injection site bruising 34.01 9.74 24 167119 38008 70723293
Osteonecrosis of jaw 33.96 9.74 28 167115 40974 70720327
Drug tolerance 33.92 9.74 62 167081 7366 70753935
Transient ischaemic attack 33.76 9.74 35 167108 45909 70715392
Accidental exposure to product 33.64 9.74 12 167131 28039 70733262
Infectious mononucleosis 33.48 9.74 31 167112 1868 70759433
Sleep disorder 33.12 9.74 72 167071 69800 70691501
Irritability 33.05 9.74 25 167118 38200 70723101
Meningitis cryptococcal 33.02 9.74 40 167103 3288 70758013
Helicobacter infection 32.96 9.74 50 167093 55606 70705695
Gastrointestinal wall thickening 32.93 9.74 34 167109 2342 70758959
Cytomegalovirus infection reactivation 32.76 9.74 58 167085 6723 70754578
Ear infection 32.69 9.74 143 167000 28193 70733108
Ventricular tachycardia 32.55 9.74 23 167120 36400 70724901
Pulmonary vasculitis 32.49 9.74 18 167125 475 70760826
Multiple sclerosis relapse 32.49 9.74 32 167111 42985 70718316
Rhegmatogenous retinal detachment 32.42 9.74 13 167130 160 70761141
Therapeutic product effect variable 32.27 9.74 29 167114 1681 70759620
Lymphadenitis 32.23 9.74 44 167099 4073 70757228
Phospholipidosis 32.14 9.74 12 167131 120 70761181
Melaena 32.07 9.74 52 167091 56303 70704998
Mucous stools 31.87 9.74 43 167100 3936 70757365
Anal cancer 31.74 9.74 20 167123 673 70760628
Dermatomyositis 31.64 9.74 40 167103 3435 70757866
Crepitations 31.60 9.74 66 167077 8648 70752653
Cutaneous leishmaniasis 31.15 9.74 15 167128 293 70761008
Proctitis 30.89 9.74 40 167103 3518 70757783
Gastrointestinal mucosa hyperaemia 30.88 9.74 17 167126 443 70760858
Malignant melanoma 30.75 9.74 87 167056 13813 70747488
Mycobacterium avium complex infection 30.70 9.74 44 167099 4262 70757039
Anorectal stenosis 30.69 9.74 9 167134 38 70761263
Bronchopulmonary aspergillosis 30.63 9.74 114 167029 20888 70740413
Dysarthria 30.55 9.74 63 167080 62250 70699051
Cytomegalovirus chorioretinitis 30.49 9.74 49 167094 5249 70756052
Skin necrosis 30.39 9.74 96 167047 16195 70745106
Antiphospholipid syndrome 30.38 9.74 28 167115 1677 70759624
Sinus bradycardia 30.28 9.74 9 167134 23614 70737687
Enterovesical fistula 30.12 9.74 23 167120 1060 70760241
Disturbance in attention 30.05 9.74 34 167109 42860 70718441
Renal mass 29.95 9.74 36 167107 2935 70758366
Device dislocation 29.91 9.74 8 167135 22499 70738802
Henoch-Schonlein purpura 29.81 9.74 33 167110 2462 70758839
Irritable bowel syndrome 29.80 9.74 46 167097 50804 70710497
Autoimmune haemolytic anaemia 29.66 9.74 60 167083 7686 70753615
Inappropriate antidiuretic hormone secretion 29.59 9.74 9 167134 23267 70738034
Pouchitis 29.54 9.74 21 167122 866 70760435
Food intolerance 29.41 9.74 37 167106 3161 70758140
Diabetic ketoacidosis 29.37 9.74 19 167124 31493 70729808
Squamous cell carcinoma of the tongue 29.26 9.74 19 167124 674 70760627
Gastrointestinal fistula 29.24 9.74 19 167124 675 70760626
Rectal discharge 29.21 9.74 19 167124 676 70760625
Natural killer-cell leukaemia 29.12 9.74 11 167132 114 70761187
Cytomegalovirus test positive 29.08 9.74 49 167094 5459 70755842
Mycoplasma infection 29.06 9.74 19 167124 682 70760619
Rectal haemorrhage 28.92 9.74 259 166884 65572 70695729
Anorectal disorder 28.88 9.74 30 167113 2081 70759220
Female genital tract fistula 28.70 9.74 36 167107 3067 70758234
Myasthenic syndrome 28.65 9.74 19 167124 699 70760602
Pruritus 28.51 9.74 609 166534 344951 70416350
Folliculitis 28.48 9.74 35 167108 42535 70718766
Foetal death 28.40 9.74 52 167091 6187 70755114
Complications of transplanted lung 28.39 9.74 16 167127 437 70760864
Anal stenosis 28.29 9.74 15 167128 362 70760939
Complications of bone marrow transplant 28.24 9.74 18 167125 618 70760683
Subdural haematoma 28.22 9.74 17 167126 29281 70732020
Lupus myocarditis 28.22 9.74 10 167133 85 70761216
Muscle rigidity 28.09 9.74 5 167138 18645 70742656
Therapy non-responder 28.06 9.74 291 166852 76624 70684677
Cow pox 28.03 9.74 8 167135 30 70761271
Lymphadenopathy 27.97 9.74 204 166939 48587 70712714
Dementia 27.80 9.74 9 167134 22356 70738945
Infection reactivation 27.69 9.74 31 167112 2342 70758959
Withdrawal syndrome 27.65 9.74 12 167131 24892 70736409
Renal transplant failure 27.63 9.74 27 167116 1741 70759560
Loss of therapeutic response 27.55 9.74 16 167127 463 70760838
Proctalgia 27.54 9.74 61 167082 8322 70752979
Anaphylactic reaction 27.51 9.74 284 166859 74690 70686611
Thiopurine methyltransferase decreased 27.45 9.74 14 167129 311 70760990
Pregnancy 27.42 9.74 120 167023 23661 70737640
Pulmonary embolism 27.40 9.74 235 166908 155632 70605669
Muscle fatigue 27.37 9.74 36 167107 3215 70758086
Opportunistic infection 27.33 9.74 33 167110 2703 70758598
Injection site inflammation 27.30 9.74 37 167106 3401 70757900
Haematoma 27.24 9.74 45 167098 48373 70712928
Memory impairment 27.13 9.74 119 167024 92522 70668779
Ganglioneuroma 27.10 9.74 11 167132 140 70761161
Delusion 27.06 9.74 6 167137 19159 70742142
Listeria sepsis 27.05 9.74 18 167125 666 70760635
Phaeohyphomycosis 26.93 9.74 22 167121 1119 70760182
Rhabdomyolysis 26.85 9.74 125 167018 95635 70665666
Rectal fissure 26.83 9.74 19 167124 779 70760522
Ejection fraction decreased 26.74 9.74 20 167123 30742 70730559
Allergy to chemicals 26.65 9.74 28 167115 1968 70759333
Serum sickness 26.60 9.74 36 167107 3305 70757996
Emotional distress 26.57 9.74 29 167114 37159 70724142
Pseudopolyp 26.47 9.74 15 167128 414 70760887
Non-Hodgkin's lymphoma 26.41 9.74 25 167118 1549 70759752
Small intestinal resection 26.24 9.74 19 167124 807 70760494
Pelvic abscess 26.20 9.74 27 167116 1856 70759445
Rectal cancer metastatic 26.03 9.74 16 167127 515 70760786
Polyomavirus-associated nephropathy 25.90 9.74 45 167098 5138 70756163
Sepsis neonatal 25.86 9.74 8 167135 42 70761259
Hepatitis 25.86 9.74 204 166939 49776 70711525
Intestinal anastomosis complication 25.81 9.74 13 167130 281 70761020
Heart rate decreased 25.72 9.74 241 166902 61774 70699527
Underdose 25.68 9.74 19 167124 29364 70731937
Splenomegaly 25.52 9.74 100 167043 18770 70742531
Sleep disorder due to general medical condition, insomnia type 25.38 9.74 28 167115 35704 70725597
Nicotinic acid deficiency 25.35 9.74 11 167132 167 70761134
Paraesthesia 25.33 9.74 220 166923 145317 70615984
Intestinal mass 25.23 9.74 21 167122 1097 70760204
Liver function test increased 25.15 9.74 151 166992 33696 70727605
Product quality issue 25.15 9.74 21 167122 30540 70730761
Creatinine renal clearance decreased 25.07 9.74 5 167138 17195 70744106
Mydriasis 25.06 9.74 4 167139 16149 70745152
Disease progression 25.03 9.74 242 166901 156430 70604871
Arrhythmia 24.87 9.74 60 167083 56083 70705218
Altered state of consciousness 24.63 9.74 35 167108 39987 70721314
Epstein Barr virus positive mucocutaneous ulcer 24.58 9.74 18 167125 778 70760523
Device issue 24.49 9.74 13 167130 24012 70737289
Hypothyroidism 24.40 9.74 44 167099 45711 70715590
Therapy cessation 24.35 9.74 26 167117 33650 70727651
Large intestinal ulcer 24.29 9.74 40 167103 4372 70756929
Meningoencephalitis viral 24.11 9.74 14 167129 405 70760896
Hepatitis cholestatic 24.02 9.74 75 167068 12575 70748726
Foetal growth restriction 24 9.74 26 167117 1893 70759408
Product label confusion 23.99 9.74 18 167125 808 70760493
Neoplasm skin 23.98 9.74 22 167121 1310 70759991
Drug withdrawal syndrome 23.95 9.74 25 167118 32690 70728611
Feeling abnormal 23.95 9.74 217 166926 142102 70619199
Splenic embolism 23.92 9.74 11 167132 193 70761108
American trypanosomiasis 23.81 9.74 13 167130 333 70760968
Acquired gene mutation 23.78 9.74 27 167116 2071 70759230
Scleroderma renal crisis 23.75 9.74 14 167129 417 70760884
Angioedema 23.75 9.74 79 167064 66531 70694770
Synovial cyst 23.69 9.74 59 167084 8683 70752618
Blood sodium decreased 23.48 9.74 23 167120 30975 70730326
Trichodysplasia spinulosa 23.44 9.74 17 167126 724 70760577
Dyspnoea exertional 23.42 9.74 100 167043 78330 70682971
Drug level abnormal 23.35 9.74 12 167131 271 70761030
Nephropathy toxic 23.35 9.74 96 167047 18418 70742883
Periumbilical abscess 23.33 9.74 8 167135 61 70761240
Cytokine release syndrome 23.28 9.74 17 167126 26450 70734851
Primary biliary cholangitis 23.24 9.74 20 167123 1094 70760207
Extrapyramidal disorder 23.03 9.74 10 167133 20740 70740561
Glossodynia 23.02 9.74 115 167028 86372 70674929
Hospitalisation 23.02 9.74 108 167035 82460 70678841
Gastrooesophageal reflux disease 22.94 9.74 123 167020 90716 70670585
Injury 22.84 9.74 78 167065 65167 70696134
Tachycardia 22.82 9.74 251 166892 158295 70603006
Faecal calprotectin abnormal 22.80 9.74 10 167133 156 70761145
Myelosuppression 22.73 9.74 135 167008 30010 70731291
Electrolyte imbalance 22.67 9.74 18 167125 26843 70734458
Tuberculosis of central nervous system 22.64 9.74 15 167128 551 70760750
Lung infiltration 22.61 9.74 106 167037 21518 70739783
Tuberculosis of eye 22.57 9.74 8 167135 68 70761233
Gait disturbance 22.49 9.74 304 166839 184802 70576499
Enterostomy 22.43 9.74 11 167132 224 70761077
Injection site warmth 22.43 9.74 3 167140 13822 70747479
Abscess rupture 22.39 9.74 12 167131 296 70761005
Rectal stenosis 22.35 9.74 12 167131 297 70761004
Bronchiectasis 22.33 9.74 86 167057 16011 70745290
Pulmonary granuloma 22.32 9.74 25 167118 1889 70759412
Microscopic polyangiitis 22.24 9.74 13 167130 381 70760920
Antisynthetase syndrome 22.19 9.74 10 167133 167 70761134
Hypophagia 22.14 9.74 40 167103 41530 70719771
Cardiogenic shock 22.10 9.74 32 167111 36275 70725026
Somatic delusion 22.00 9.74 16 167127 684 70760617
Optic neuritis 21.98 9.74 58 167085 8842 70752459
Cholesteatoma 21.93 9.74 9 167134 118 70761183
Graft versus host disease in lung 21.90 9.74 17 167126 803 70760498
Polymyositis 21.89 9.74 31 167112 2970 70758331
Head injury 21.87 9.74 29 167114 34112 70727189
Chest pain 21.83 9.74 439 166704 250821 70510480
Myoclonus 21.82 9.74 18 167125 26337 70734964
Injection site mass 21.73 9.74 8 167135 18335 70742966
Tonsil cancer 21.73 9.74 19 167124 1062 70760239
Hidradenitis 21.72 9.74 31 167112 2991 70758310
Anaplastic large cell lymphoma T- and null-cell types 21.71 9.74 10 167133 176 70761125
Paracoccidioides infection 21.70 9.74 8 167135 77 70761224
Tonsillar hypertrophy 21.70 9.74 21 167122 1338 70759963
Hypersensitivity vasculitis 21.69 9.74 49 167094 6773 70754528
Mouth ulceration 21.67 9.74 147 166996 34202 70727099
Dermatitis psoriasiform 21.66 9.74 27 167116 2286 70759015
Enteritis 21.59 9.74 73 167070 12758 70748543
Salmonellosis 21.48 9.74 22 167121 1501 70759800
Tenderness 21.47 9.74 103 167040 21107 70740194
Urinary incontinence 21.45 9.74 35 167108 37807 70723494
Bronchitis 21.40 9.74 175 166968 117068 70644233
Amnesia 21.36 9.74 58 167085 52097 70709204
Glomerulosclerosis 21.32 9.74 18 167125 959 70760342
Growth retardation 21.29 9.74 23 167120 1669 70759632
Laryngeal disorder 21.27 9.74 18 167125 962 70760339
Cytomegalovirus duodenitis 21.25 9.74 8 167135 82 70761219
Neoplasm malignant 21.15 9.74 128 167015 28646 70732655
Hypoxia 21.10 9.74 131 167012 93213 70668088
Muscle spasticity 21.06 9.74 10 167133 19679 70741622
Diffuse large B-cell lymphoma stage IV 21.05 9.74 15 167128 621 70760680
Upper gastrointestinal haemorrhage 20.93 9.74 35 167108 37442 70723859
Impaired healing 20.90 9.74 97 167046 74277 70687024
Depressed mood 20.90 9.74 45 167098 43775 70717526
Intestinal mucosal hypertrophy 20.87 9.74 11 167132 262 70761039
Pollakiuria 20.85 9.74 29 167114 33432 70727869
Eye infection toxoplasmal 20.85 9.74 14 167129 526 70760775
Conjunctivitis 20.83 9.74 107 167036 22529 70738772
Chest discomfort 20.77 9.74 190 166953 124191 70637110
Jejunal stenosis 20.75 9.74 8 167135 88 70761213
Stiff person syndrome 20.74 9.74 12 167131 345 70760956
Ventricular fibrillation 20.67 9.74 20 167123 27091 70734210
Abnormal faeces 20.66 9.74 47 167096 6526 70754775
Intestinal ulcer 20.66 9.74 23 167120 1727 70759574
Lymphocytic infiltration 20.53 9.74 21 167122 1431 70759870
B-cell unclassifiable lymphoma high grade 20.51 9.74 5 167138 8 70761293
Jaw fracture 20.37 9.74 29 167114 2792 70758509
Vasculitis necrotising 20.24 9.74 19 167124 1165 70760136
Haematemesis 20.19 9.74 54 167089 48743 70712558
Bowel movement irregularity 20.06 9.74 41 167102 5291 70756010
Femur fracture 19.94 9.74 34 167109 36098 70725203
Ischaemic stroke 19.93 9.74 26 167117 30794 70730507
Small intestine adenocarcinoma 19.88 9.74 9 167134 152 70761149
Cytomegalovirus syndrome 19.87 9.74 11 167132 290 70761011
Exposure to SARS-CoV-2 19.82 9.74 19 167124 1196 70760105
Nightmare 19.79 9.74 14 167129 22142 70739159
Antineutrophil cytoplasmic antibody increased 19.77 9.74 9 167134 154 70761147
Adenocarcinoma of colon 19.74 9.74 41 167102 5351 70755950
Stevens-Johnson syndrome 19.62 9.74 34 167109 35873 70725428
Chorioretinitis 19.57 9.74 17 167126 942 70760359
HELLP syndrome 19.50 9.74 15 167128 699 70760602
Wrist deformity 19.49 9.74 23 167120 1839 70759462
Renal transplant 19.42 9.74 26 167117 2362 70758939
Encephalopathy 19.42 9.74 77 167066 61584 70699717
Dysplasia 19.40 9.74 19 167124 1228 70760073
Rash maculo-papular 19.38 9.74 58 167085 50487 70710814
Hepatitis viral 19.34 9.74 17 167126 957 70760344
Anogenital warts 19.33 9.74 16 167127 829 70760472
Therapy interrupted 19.25 9.74 18 167125 24784 70736517
Leiomyosarcoma metastatic 19.17 9.74 6 167137 33 70761268
Hip fracture 19.15 9.74 23 167120 28240 70733061
Hepatic enzyme increased 19.14 9.74 495 166648 156495 70604806
Intestinal fibrosis 19.02 9.74 8 167135 112 70761189
Drug specific antibody absent 19.01 9.74 9 167134 169 70761132
Product administration error 18.99 9.74 25 167118 29498 70731803
Pulmonary nocardiosis 18.97 9.74 16 167127 851 70760450
Epstein-Barr viraemia 18.89 9.74 23 167120 1900 70759401
Trichostasis spinulosa 18.89 9.74 5 167138 13 70761288
Infective pulmonary exacerbation of cystic fibrosis 18.88 9.74 3 167140 12155 70749146
Hyperthyroidism 18.88 9.74 12 167131 20079 70741222
Hodgkin's disease 18.88 9.74 16 167127 857 70760444
Central nervous system vasculitis 18.82 9.74 19 167124 1274 70760027
Nodule 18.80 9.74 95 167048 19874 70741427
Blood bilirubin increased 18.74 9.74 75 167068 59826 70701475
Graft loss 18.73 9.74 17 167126 998 70760303
Porokeratosis 18.72 9.74 10 167133 245 70761056
Ileectomy 18.68 9.74 9 167134 176 70761125
Chronic hepatitis 18.66 9.74 19 167124 1287 70760014
Colectomy total 18.65 9.74 10 167133 247 70761054
Dyspepsia 18.62 9.74 128 167015 88949 70672352
Hallucination, auditory 18.56 9.74 10 167133 18318 70742983
Rheumatoid factor positive 18.55 9.74 185 166958 48215 70713086
Peritoneal tuberculosis 18.55 9.74 13 167130 524 70760777
Febrile bone marrow aplasia 18.53 9.74 3 167140 11988 70749313
Premature separation of placenta 18.50 9.74 18 167125 1154 70760147
Anaphylactic shock 18.46 9.74 30 167113 32460 70728841
Troponin increased 18.45 9.74 8 167135 16606 70744695
Flank pain 18.45 9.74 86 167057 17416 70743885
Palatal ulcer 18.41 9.74 8 167135 122 70761179
Cervical dysplasia 18.39 9.74 23 167120 1953 70759348
Chronic gastrointestinal bleeding 18.37 9.74 12 167131 430 70760871
Necrotising herpetic retinopathy 18.35 9.74 8 167135 123 70761178
Carcinoid tumour pulmonary 18.29 9.74 11 167132 340 70760961
Cryptococcosis 18.21 9.74 30 167113 3280 70758021
Blood glucose decreased 18.21 9.74 18 167125 24141 70737160
Immune-mediated myositis 18.18 9.74 29 167114 3087 70758214
Systemic candida 18.18 9.74 42 167101 5892 70755409
Dry skin 18.16 9.74 69 167074 55862 70705439
Polyhydramnios 18.13 9.74 20 167123 1486 70759815
Abdominal pain upper 18.11 9.74 334 166809 193268 70568033
Oxygen saturation decreased 18.10 9.74 181 166962 116248 70645053
Peripheral T-cell lymphoma unspecified stage IV 18.06 9.74 6 167137 41 70761260
Transient hypogammaglobulinaemia of infancy 18.06 9.74 6 167137 41 70761260
Fear of injection 18.05 9.74 45 167098 6627 70754674
Brain stem syndrome 17.95 9.74 15 167128 788 70760513
Eye ulcer 17.88 9.74 10 167133 269 70761032
Gestational diabetes 17.86 9.74 42 167101 5959 70755342
Atrioventricular block first degree 17.86 9.74 3 167140 11670 70749631
Chronic myeloid leukaemia 17.85 9.74 34 167109 4167 70757134
Joint effusion 17.77 9.74 78 167065 15399 70745902
Muscular dystrophy 17.73 9.74 8 167135 134 70761167
Weber tuning fork test abnormal 17.61 9.74 7 167136 84 70761217
Tractional retinal detachment 17.61 9.74 7 167136 84 70761217
Behcet's syndrome 17.54 9.74 7 167136 85 70761216
Fear 17.49 9.74 14 167129 20797 70740504
Burkitt's lymphoma stage III 17.47 9.74 5 167138 19 70761282
Pseudoxanthoma elasticum-like syndrome 17.45 9.74 4 167139 4 70761297
Anastomotic stenosis 17.45 9.74 12 167131 469 70760832
Autoimmune neutropenia 17.43 9.74 12 167131 470 70760831
Cytomegalovirus oesophagitis 17.38 9.74 14 167129 698 70760603
Small intestine carcinoma 17.28 9.74 16 167127 964 70760337
Pneumonia legionella 17.10 9.74 26 167117 2656 70758645
Disseminated cryptococcosis 16.96 9.74 21 167122 1766 70759535
Toxic epidermal necrolysis 16.95 9.74 43 167100 39514 70721787
Cytomegalovirus hepatitis 16.94 9.74 14 167129 724 70760577
Oesophageal squamous cell carcinoma 16.92 9.74 12 167131 493 70760808
Pancreatitis acute 16.92 9.74 172 166971 45052 70716249
Acute respiratory failure 16.91 9.74 67 167076 53598 70707703
Retinal scar 16.85 9.74 11 167132 394 70760907
Marrow hyperplasia 16.81 9.74 19 167124 1450 70759851
Bacillary angiomatosis 16.79 9.74 9 167134 222 70761079
Lymph node tuberculosis 16.79 9.74 16 167127 1000 70760301
Blood potassium decreased 16.76 9.74 48 167095 42373 70718928
Hallucination, visual 16.75 9.74 27 167116 29310 70731991
Viral test positive 16.72 9.74 11 167132 399 70760902
Atrial flutter 16.68 9.74 14 167129 20313 70740988
Aspergillosis oral 16.63 9.74 6 167137 54 70761247
Leiomyosarcoma 16.60 9.74 10 167133 310 70760991
Ileal ulcer 16.59 9.74 16 167127 1015 70760286
Prostate cancer 16.59 9.74 30 167113 31133 70730168
Hodgkin's disease nodular sclerosis 16.53 9.74 5 167138 24 70761277
Injection site pruritus 16.52 9.74 43 167100 39167 70722134
Gastrointestinal obstruction 16.50 9.74 19 167124 1480 70759821
Haematocrit decreased 16.49 9.74 74 167069 57184 70704117
Respiratory gas exchange disorder 16.45 9.74 14 167129 754 70760547
Skin exfoliation 16.43 9.74 59 167084 48567 70712734
Salivary hypersecretion 16.43 9.74 5 167138 12920 70748381
Abdominal discomfort 16.34 9.74 383 166760 214275 70547026
Epstein-Barr virus infection reactivation 16.33 9.74 19 167124 1497 70759804
Deep vein thrombosis 16.29 9.74 175 166968 110867 70650434
Tricuspid valve incompetence 16.26 9.74 11 167132 17806 70743495
Cystitis escherichia 16.22 9.74 12 167131 527 70760774
Rectal tenesmus 16.20 9.74 18 167125 1348 70759953
Necrotising retinitis 16.19 9.74 17 167126 1194 70760107
Cough 16.19 9.74 615 166528 324762 70436539
Malignant polyp 16.18 9.74 8 167135 166 70761135
Testicular cancer metastatic 16.16 9.74 6 167137 59 70761242
Psychotic disorder 16.14 9.74 41 167102 37660 70723641
Skin cancer 16.14 9.74 69 167074 13467 70747834
Device difficult to use 16.14 9.74 3 167140 10846 70750455
Swollen tongue 16.09 9.74 40 167103 37006 70724295
Dysphagia 16.08 9.74 179 166964 112655 70648646
Palpitations 16.07 9.74 175 166968 110578 70650723
Sideroblastic anaemia 16.06 9.74 9 167134 243 70761058
Parkinsonism 16.06 9.74 8 167135 15317 70745984
Anger 16.05 9.74 9 167134 16123 70745178
Stress at work 16.05 9.74 16 167127 1057 70760244
Meningitis aseptic 16.02 9.74 42 167101 6377 70754924
Inflammatory pain 15.98 9.74 15 167128 920 70760381
Wound 15.97 9.74 152 166991 98580 70662721
Narcotic bowel syndrome 15.96 9.74 9 167134 246 70761055
Hirsutism 15.91 9.74 16 167127 1068 70760233
Gastrointestinal stoma output abnormal 15.90 9.74 6 167137 62 70761239
Acne conglobata 15.90 9.74 5 167138 28 70761273
Lung neoplasm 15.87 9.74 42 167101 6412 70754889
Oesophagitis 15.82 9.74 18 167125 22634 70738667
Lethargy 15.79 9.74 108 167035 75142 70686159
Hypergammaglobulinaemia 15.78 9.74 13 167130 669 70760632
Anastomotic complication 15.77 9.74 11 167132 440 70760861
Blood potassium increased 15.75 9.74 25 167118 27301 70734000
Mucocutaneous leishmaniasis 15.68 9.74 11 167132 444 70760857
Intestinal dilatation 15.67 9.74 23 167120 2277 70759024
Ventricular extrasystoles 15.65 9.74 12 167131 18214 70743087
Neutrophilic dermatosis 15.64 9.74 12 167131 557 70760744
Drug resistance 15.63 9.74 148 166995 38042 70723259
Polyuria 15.63 9.74 6 167137 13400 70747901
Angina unstable 15.62 9.74 9 167134 15884 70745417
Sebaceous carcinoma 15.58 9.74 7 167136 116 70761185
Hot flush 15.56 9.74 62 167081 49522 70711779
Anaplastic large-cell lymphoma 15.55 9.74 10 167133 349 70760952
Discomfort 15.53 9.74 166 166977 105270 70656031
Diarrhoea 15.52 9.74 1613 165530 781728 69979573
Gastrointestinal stoma complication 15.51 9.74 23 167120 2297 70759004
Necrosis 15.49 9.74 50 167093 8531 70752770
Pulmonary congestion 15.47 9.74 22 167121 25132 70736169
Exercise tolerance increased 15.47 9.74 5 167138 31 70761270
Pneumonitis 15.46 9.74 71 167072 54526 70706775
Mycetoma mycotic 15.42 9.74 7 167136 119 70761182
Drug specific antibody 15.37 9.74 23 167120 2316 70758985
Corynebacterium infection 15.37 9.74 16 167127 1113 70760188
DNA antibody 15.33 9.74 5 167138 32 70761269
Fistula of small intestine 15.28 9.74 13 167130 700 70760601
Pharyngeal oedema 15.27 9.74 9 167134 15687 70745614
Sleep apnoea syndrome 15.26 9.74 34 167109 32679 70728622
Herpes zoster meningoencephalitis 15.25 9.74 13 167130 702 70760599
Appendicectomy 15.23 9.74 23 167120 2335 70758966
Haemophilus infection 15.20 9.74 21 167122 1966 70759335
Blood cholesterol increased 15.15 9.74 225 166918 64379 70696922
Peripheral swelling 15.11 9.74 433 166710 236130 70525171
Laryngeal mass 15.10 9.74 6 167137 72 70761229
Injection site haemorrhage 15.05 9.74 23 167120 25504 70735797
Atypical mycobacterial infection 15.03 9.74 18 167125 1462 70759839
Drug interaction 15.02 9.74 740 166403 380701 70380600
Connective tissue disorder 15.01 9.74 16 167127 1144 70760157
Focal segmental glomerulosclerosis 14.96 9.74 27 167116 3177 70758124
Cardiac valve vegetation 14.93 9.74 14 167129 857 70760444
Pseudomonas infection 14.93 9.74 86 167057 18908 70742393
Diaphragmatic injury 14.91 9.74 7 167136 129 70761172
Proctitis ulcerative 14.89 9.74 9 167134 281 70761020
Oral lichen planus 14.88 9.74 13 167130 726 70760575
Sinusitis 14.87 9.74 295 166848 168900 70592401
Acinetobacter infection 14.87 9.74 24 167119 2580 70758721
Electrocardiogram abnormal 14.85 9.74 8 167135 14656 70746645
Mycoplasma test positive 14.76 9.74 8 167135 202 70761099
Aspiration 14.72 9.74 12 167131 17663 70743638
Thinking abnormal 14.72 9.74 5 167138 12046 70749255
Placental necrosis 14.70 9.74 4 167139 12 70761289
Tinea capitis 14.70 9.74 4 167139 12 70761289
Blood urea increased 14.67 9.74 57 167086 45852 70715449
Epstein-Barr virus antibody positive 14.65 9.74 12 167131 613 70760688
Gastrointestinal bacterial infection 14.63 9.74 13 167130 742 70760559
Product storage error 14.63 9.74 8 167135 14533 70746768
Acne 14.62 9.74 105 167038 24884 70736417
Cardiotoxicity 14.59 9.74 4 167139 11066 70750235
Oral pain 14.58 9.74 29 167114 29037 70732264
Hyperlipidaemia 14.55 9.74 21 167122 23842 70737459
Laparotomy 14.54 9.74 10 167133 391 70760910
Herpes simplex test positive 14.54 9.74 10 167133 391 70760910
Mitochondrial neurogastrointestinal encephalopathy 14.46 9.74 4 167139 13 70761288
Retinal injury 14.41 9.74 9 167134 298 70761003
Pyometra 14.40 9.74 6 167137 82 70761219
Hepatitis B 14.39 9.74 47 167096 8067 70753234
Infertility 14.38 9.74 12 167131 629 70760672
Listeria encephalitis 14.36 9.74 9 167134 300 70761001
Eosinophilic bronchitis 14.25 9.74 10 167133 404 70760897
Human ehrlichiosis 14.23 9.74 10 167133 405 70760896
Ileal perforation 14.21 9.74 14 167129 912 70760389
Biopsy muscle abnormal 14.16 9.74 5 167138 42 70761259
Skin papilloma 14.14 9.74 36 167107 5370 70755931
Pleural effusion 14.11 9.74 224 166919 132640 70628661
Toxic skin eruption 14.10 9.74 16 167127 20146 70741155
Metastases to central nervous system 14.10 9.74 9 167134 15025 70746276
Tuberous sclerosis complex 14.02 9.74 6 167137 88 70761213
Retinal vasculitis 14.00 9.74 16 167127 1236 70760065
Herpes simplex 13.97 9.74 58 167085 11174 70750127
Acute coronary syndrome 13.97 9.74 16 167127 20063 70741238
Complications of transplanted heart 13.97 9.74 9 167134 315 70760986
Skin mass 13.96 9.74 44 167099 7412 70753889
Anal skin tags 13.95 9.74 10 167133 418 70760883
Cystitis 13.92 9.74 60 167083 46881 70714420
Pulmonary haemosiderosis 13.86 9.74 5 167138 45 70761256
Enterobacter infection 13.85 9.74 30 167113 4030 70757271
Glomerulonephritis 13.85 9.74 26 167117 3152 70758149
Ureteral neoplasm 13.81 9.74 4 167139 16 70761285
Pulmonary paracoccidioidomycosis 13.81 9.74 4 167139 16 70761285
Generalised tonic-clonic seizure 13.78 9.74 51 167092 41610 70719691
Diabetes mellitus inadequate control 13.74 9.74 20 167123 22625 70738676
Oedema 13.72 9.74 167 166976 103414 70657887
Adverse reaction 13.72 9.74 48 167095 8534 70752767
Dysphonia 13.69 9.74 66 167077 50034 70711267
Enterocolonic fistula 13.66 9.74 7 167136 157 70761144
Renal failure 13.66 9.74 340 166803 188730 70572571
Gastrointestinal oedema 13.61 9.74 22 167121 2368 70758933
Premature baby 13.60 9.74 27 167116 3412 70757889
Cyanosis 13.59 9.74 21 167122 23185 70738116
Joint tuberculosis 13.54 9.74 7 167136 160 70761141
Arteriosclerosis coronary artery 13.52 9.74 11 167132 16204 70745097
Spondylitis 13.50 9.74 27 167116 3430 70757871
Proctectomy 13.49 9.74 6 167137 97 70761204
Second primary malignancy 13.40 9.74 7 167136 13044 70748257
Respiratory tract infection fungal 13.35 9.74 15 167128 1138 70760163
Blood creatine phosphokinase increased 13.32 9.74 87 167056 61176 70700125
Coordination abnormal 13.27 9.74 11 167132 16055 70745246
Takayasu's arteritis 13.26 9.74 4 167139 19 70761282
Anal ulcer 13.25 9.74 15 167128 1147 70760154
Incorrect dose administered 13.25 9.74 226 166917 66493 70694808
Epistaxis 13.21 9.74 326 166817 102301 70659000
Tonsillitis 13.16 9.74 38 167105 6102 70755199
Obstructive airways disorder 13.14 9.74 26 167117 26087 70735214
Oesophagopleural fistula 13.14 9.74 5 167138 53 70761248
Rhinitis 13.11 9.74 58 167085 11489 70749812
Cholecystitis chronic 13.11 9.74 3 167140 9373 70751928
Peritoneal candidiasis 13.09 9.74 4 167139 20 70761281
Pulmonary thrombosis 13.09 9.74 5 167138 11203 70750098
Precursor T-lymphoblastic lymphoma/leukaemia stage I 13.09 9.74 3 167140 3 70761298
Enterostomy closure 13.09 9.74 3 167140 3 70761298
Antineutrophil cytoplasmic antibody decreased 13.09 9.74 3 167140 3 70761298
Faecaluria 13.09 9.74 3 167140 3 70761298
Subarachnoid haemorrhage 13.08 9.74 16 167127 19488 70741813
Perirectal abscess 13.02 9.74 19 167124 1871 70759430
Product dispensing error 12.99 9.74 6 167137 12002 70749299
Mediastinal effusion 12.97 9.74 5 167138 55 70761246
Myelitis transverse 12.94 9.74 18 167125 1696 70759605
Eosinophilia 12.92 9.74 50 167093 40269 70721032
Neuropsychiatric lupus 12.91 9.74 7 167136 177 70761124
Erectile dysfunction 12.88 9.74 8 167135 13554 70747747
Gastrointestinal scarring 12.84 9.74 8 167135 264 70761037
Tumour lysis syndrome 12.83 9.74 19 167124 21341 70739960
Tinnitus 12.83 9.74 43 167100 36133 70725168
Gastrointestinal ulcer 12.81 9.74 25 167118 3120 70758181
Scleroderma 12.77 9.74 33 167110 4968 70756333
Mania 12.71 9.74 13 167130 17161 70744140
Mycobacterium kansasii infection 12.71 9.74 9 167134 369 70760932
Urticaria 12.69 9.74 487 166656 162562 70598739
Renal impairment 12.69 9.74 436 166707 143501 70617800
Vitamin B1 decreased 12.69 9.74 9 167134 370 70760931
Hepatic fibrosis 12.68 9.74 38 167105 6229 70755072
Injection site induration 12.68 9.74 3 167140 9165 70752136
Complication associated with device 12.68 9.74 11 167132 15702 70745599
Impetigo 12.64 9.74 19 167124 1921 70759380
Whipple's disease 12.63 9.74 4 167139 23 70761278
Immunodeficiency common variable 12.62 9.74 8 167135 272 70761029
Hepatic cytolysis 12.60 9.74 16 167127 19176 70742125
Intestinal polyp 12.60 9.74 19 167124 1926 70759375
Pyoderma 12.58 9.74 9 167134 375 70760926
Drug withdrawal syndrome neonatal 12.57 9.74 8 167135 274 70761027
Gastroenterostomy 12.51 9.74 5 167138 61 70761240
Fungal peritonitis 12.50 9.74 14 167129 1058 70760243
Intestinal operation 12.49 9.74 10 167133 494 70760807
Failed induction of labour 12.49 9.74 8 167135 277 70761024
Pneumonia cryptococcal 12.47 9.74 16 167127 1394 70759907
Herpes virus infection 12.47 9.74 39 167104 6545 70754756
Skin striae 12.44 9.74 17 167126 1575 70759726
Sudden death 12.39 9.74 19 167124 21045 70740256
Dystonia 12.36 9.74 17 167126 19689 70741612
Laser therapy 12.35 9.74 4 167139 25 70761276
DNA antibody positive 12.34 9.74 8 167135 283 70761018
Anal squamous cell carcinoma 12.34 9.74 10 167133 503 70760798
Femoral artery aneurysm 12.29 9.74 7 167136 195 70761106
Butterfly rash 12.29 9.74 16 167127 1414 70759887
Anastomotic fistula 12.29 9.74 6 167137 121 70761180
Presyncope 12.27 9.74 46 167097 37392 70723909
Lower gastrointestinal haemorrhage 12.25 9.74 10 167133 14710 70746591
Lupus vulgaris 12.24 9.74 12 167131 777 70760524
Gastrointestinal dilation procedure 12.23 9.74 3 167140 5 70761296
Pulmonary function test increased 12.23 9.74 3 167140 5 70761296
Psychomotor hyperactivity 12.22 9.74 11 167132 15422 70745879
Cerebral infarction 12.14 9.74 56 167087 42953 70718348
Diffuse large B-cell lymphoma stage III 12.11 9.74 6 167137 125 70761176
Mucormycosis 12.10 9.74 44 167099 7970 70753331
Lupus endocarditis 12.07 9.74 7 167136 202 70761099
Iron deficiency 12.07 9.74 43 167100 7713 70753588
Cutaneous lupus erythematosus 12.04 9.74 23 167120 2825 70758476
Akathisia 12.03 9.74 7 167136 12286 70749015
Pseudopolyposis 12.02 9.74 5 167138 68 70761233
Skin hyperpigmentation 12.01 9.74 39 167104 6676 70754625
Shock haemorrhagic 11.99 9.74 15 167128 18091 70743210
Trichosporon infection 11.98 9.74 13 167130 948 70760353
Thrombocytosis 11.98 9.74 43 167100 7741 70753560
Herpes simplex colitis 11.96 9.74 4 167139 28 70761273
Abnormal dreams 11.94 9.74 5 167138 10598 70750703
Abscess neck 11.94 9.74 14 167129 1112 70760189
Peripheral artery aneurysm 11.92 9.74 9 167134 408 70760893
Anovulatory cycle 11.90 9.74 6 167137 130 70761171
Varicella zoster pneumonia 11.90 9.74 6 167137 130 70761171
Acute haemorrhagic ulcerative colitis 11.88 9.74 3 167140 6 70761295
Actinic cheilitis 11.88 9.74 3 167140 6 70761295
Actinomycotic skin infection 11.88 9.74 3 167140 6 70761295
Cryoglobulins present 11.88 9.74 3 167140 6 70761295
Anaplastic large cell lymphoma T- and null-cell types stage III 11.88 9.74 3 167140 6 70761295
Rash pustular 11.87 9.74 52 167091 10256 70751045
Cardiomegaly 11.87 9.74 25 167118 24520 70736781
Epilepsy 11.86 9.74 49 167094 38735 70722566
Taste disorder 11.84 9.74 6 167137 11379 70749922
Dengue fever 11.79 9.74 12 167131 813 70760488
Hypertensive crisis 11.70 9.74 17 167126 19245 70742056
Infection 11.66 9.74 608 166535 210177 70551124
Vertigo 11.66 9.74 93 167050 62550 70698751
Feeling jittery 11.64 9.74 56 167087 11487 70749814
Headache 11.62 9.74 1194 165949 579211 70182090
Haemolysis 11.62 9.74 56 167087 11495 70749806
Polychondritis 11.62 9.74 10 167133 547 70760754
Blood glucose abnormal 11.61 9.74 4 167139 9553 70751748
Mood altered 11.60 9.74 13 167130 16462 70744839
Burning sensation 11.53 9.74 75 167068 52795 70708506
Gastrointestinal motility disorder 11.50 9.74 34 167109 5532 70755769
Metastases to bone 11.50 9.74 22 167121 22354 70738947
Cholangitis chronic 11.50 9.74 4 167139 32 70761269
Drain placement 11.50 9.74 6 167137 140 70761161
Muscle spasms 11.49 9.74 458 166685 153588 70607713
Graft complication 11.47 9.74 11 167132 693 70760608
Cerebral haemorrhage 11.45 9.74 77 167066 53787 70707514
Renal atrophy 11.45 9.74 17 167126 1700 70759601
Rotator cuff syndrome 11.43 9.74 8 167135 12726 70748575
Prostatic specific antigen increased 11.43 9.74 4 167139 9462 70751839
Transplant failure 11.42 9.74 28 167115 4079 70757222
Speech disorder 11.42 9.74 71 167072 50509 70710792
Abdominal pain lower 11.37 9.74 109 167034 28107 70733194
Gastric ulcer haemorrhage 11.37 9.74 3 167140 8515 70752786
Chronic graft versus host disease in intestine 11.36 9.74 8 167135 325 70760976
Vascular graft complication 11.34 9.74 6 167137 144 70761157
Cardiac failure chronic 11.32 9.74 5 167138 10264 70751037
Spindle cell sarcoma 11.31 9.74 7 167136 228 70761073
Acute pulmonary oedema 11.30 9.74 9 167134 13403 70747898
Joint dislocation reduction 11.29 9.74 4 167139 34 70761267
Lacrimal haemorrhage 11.29 9.74 4 167139 34 70761267
Threatened labour 11.27 9.74 10 167133 570 70760731
Foetal exposure during pregnancy 11.21 9.74 34 167109 5611 70755690
Osteomyelitis 11.19 9.74 115 167028 30203 70731098
Fasting 11.19 9.74 4 167139 35 70761266
Cervix carcinoma 11.18 9.74 19 167124 2131 70759170
Burkitt's lymphoma 11.16 9.74 6 167137 149 70761152
Campylobacter gastroenteritis 11.16 9.74 14 167129 1193 70760108
Small intestinal perforation 11.16 9.74 23 167120 2986 70758315
Anaemia macrocytic 11.14 9.74 32 167111 5123 70756178
Mycobacterium chelonae infection 11.14 9.74 20 167123 2344 70758957
Device leakage 11.13 9.74 4 167139 9304 70751997
Bone density decreased 11.10 9.74 55 167088 11419 70749882
Nervousness 11.03 9.74 37 167106 31083 70730218
Hepatobiliary cancer 11.02 9.74 3 167140 9 70761292
B-cell lymphoma stage IV 10.96 9.74 5 167138 86 70761215
Primary effusion lymphoma 10.96 9.74 5 167138 86 70761215
Rectal cancer 10.95 9.74 24 167119 3250 70758051
Eosinophilic myocarditis 10.95 9.74 12 167131 885 70760416
Gastric fistula 10.91 9.74 6 167137 156 70761145
Glycosylated haemoglobin increased 10.91 9.74 15 167128 17376 70743925
Total bile acids increased 10.91 9.74 5 167138 87 70761214
IgA nephropathy 10.91 9.74 16 167127 1583 70759718
Molluscum contagiosum 10.88 9.74 9 167134 466 70760835
Lentigo maligna 10.86 9.74 9 167134 467 70760834
Germ cell cancer 10.84 9.74 6 167137 158 70761143
Faeces discoloured 10.84 9.74 30 167113 26779 70734522
Kidney fibrosis 10.82 9.74 24 167119 3276 70758025
Apnoea 10.80 9.74 6 167137 10803 70750498
Iron deficiency anaemia 10.77 9.74 92 167051 22980 70738321
Cerebral fungal infection 10.76 9.74 8 167135 354 70760947
Paranoia 10.75 9.74 15 167128 17273 70744028
Hospice care 10.75 9.74 3 167140 8202 70753099
Skin abrasion 10.72 9.74 8 167135 12309 70748992
Photophobia 10.70 9.74 78 167065 18572 70742729
Stoma complication 10.68 9.74 10 167133 611 70760690
Hiatus hernia 10.67 9.74 21 167122 21113 70740188
Laryngeal stenosis 10.66 9.74 12 167131 912 70760389
Muscle twitching 10.63 9.74 19 167124 19808 70741493
Chronic granulomatous disease 10.63 9.74 4 167139 41 70761260
Vascular shunt 10.63 9.74 4 167139 41 70761260
Superinfection viral 10.63 9.74 4 167139 41 70761260
Pharyngitis bacterial 10.62 9.74 7 167136 255 70761046
Heparin-induced thrombocytopenia 10.61 9.74 4 167139 9033 70752268
Pneumonia herpes viral 10.61 9.74 6 167137 165 70761136
Overgrowth bacterial 10.57 9.74 6 167137 166 70761135
Gingival hypertrophy 10.57 9.74 22 167121 2876 70758425
Complement factor C3 decreased 10.55 9.74 8 167135 365 70760936
Infective tenosynovitis 10.55 9.74 8 167135 365 70760936
Oropharyngeal squamous cell carcinoma 10.54 9.74 7 167136 258 70761043
Anorectal discomfort 10.48 9.74 23 167120 3118 70758183
Thrombotic microangiopathy 10.44 9.74 75 167068 17773 70743528
Deafness transitory 10.41 9.74 12 167131 936 70760365
Myelitis 10.39 9.74 19 167124 2258 70759043
Skin neoplasm excision 10.39 9.74 12 167131 938 70760363
Cushing's syndrome 10.38 9.74 12 167131 939 70760362
Metastatic malignant melanoma 10.37 9.74 23 167120 3141 70758160
Uveal melanoma 10.36 9.74 3 167140 12 70761289
Back disorder 10.36 9.74 6 167137 10558 70750743
Peritoneal abscess 10.35 9.74 7 167136 266 70761035
Visual impairment 10.35 9.74 255 166888 79995 70681306
Cytomegalovirus enterocolitis 10.35 9.74 15 167128 1468 70759833
Colonoscopy abnormal 10.32 9.74 6 167137 174 70761127
Stenosis 10.31 9.74 18 167125 2063 70759238
Panic attack 10.31 9.74 23 167120 22096 70739205
Urinary tract infection 10.30 9.74 480 166663 248289 70513012
Foetal malpresentation 10.28 9.74 5 167138 100 70761201
Sinus tachycardia 10.27 9.74 43 167100 33870 70727431
Renal cell carcinoma stage III 10.22 9.74 4 167139 46 70761255
Spleen palpable 10.17 9.74 3 167140 13 70761288
Cryptococcal cutaneous infection 10.17 9.74 6 167137 179 70761122
Infusion site paraesthesia 10.17 9.74 3 167140 13 70761288
Red blood cell sedimentation rate 10.15 9.74 30 167113 4880 70756421
Weight fluctuation 10.14 9.74 47 167096 9494 70751807
Amniotic cavity infection 10.14 9.74 11 167132 802 70760499
Polyarteritis nodosa 10.14 9.74 9 167134 513 70760788
Panniculitis lobular 10.14 9.74 4 167139 47 70761254
Cutaneous nocardiosis 10.14 9.74 6 167137 180 70761121
Klebsiella infection 10.14 9.74 63 167080 14229 70747072
Relapsing fever 10.10 9.74 8 167135 389 70760912
Paraproteinaemia 10.10 9.74 8 167135 389 70760912
Central nervous system necrosis 10.10 9.74 7 167136 277 70761024
Superficial spreading melanoma stage unspecified 10.08 9.74 7 167136 278 70761023
Hepatitis chronic active 10.08 9.74 6 167137 182 70761119
Infective aortitis 10.07 9.74 4 167139 48 70761253
Colonic abscess 10.04 9.74 13 167130 1143 70760158
Torsade de pointes 10.04 9.74 17 167126 18099 70743202
Pachymeningitis 10.04 9.74 7 167136 280 70761021
Throat cancer 10.02 9.74 14 167129 1324 70759977
Parvovirus B19 infection 9.93 9.74 14 167129 1335 70759966
Tongue ulceration 9.92 9.74 25 167118 3706 70757595
Renal tubular atrophy 9.87 9.74 16 167127 1726 70759575
Herpes ophthalmic 9.87 9.74 14 167129 1343 70759958
Renal phospholipidosis 9.85 9.74 5 167138 110 70761191
Fibroadenoma of breast 9.84 9.74 7 167136 289 70761012
Ocular toxicity 9.84 9.74 11 167132 830 70760471
Gastroenteritis clostridial 9.82 9.74 11 167132 831 70760470
Unevaluable event 9.82 9.74 77 167066 51986 70709315
Metastases to nasal sinuses 9.82 9.74 3 167140 15 70761286
Conjunctivochalasis 9.82 9.74 3 167140 15 70761286
Liver sarcoidosis 9.82 9.74 3 167140 15 70761286
Left ventricular dysfunction 9.82 9.74 17 167126 17940 70743361
Emotional disorder 9.80 9.74 10 167133 13216 70748085
Muir-Torre syndrome 9.78 9.74 4 167139 52 70761249
Telangiectasia 9.77 9.74 13 167130 1174 70760127

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hydrops foetalis 56.73 35.01 17 200 80 89495

Pharmacologic Action:

SourceCodeDescription
ATC L04AX01 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
IMMUNOSUPPRESSANTS
IMMUNOSUPPRESSANTS
Other immunosuppressants
FDA CS M0015066 Nucleosides
FDA CS M0018169 Purines
FDA MoA N0000000233 Nucleic Acid Synthesis Inhibitors
MeSH PA D000963 Antimetabolites
MeSH PA D000964 Antimetabolites, Antineoplastic
MeSH PA D000970 Antineoplastic Agents
MeSH PA D018501 Antirheumatic Agents
MeSH PA D007155 Immunologic Factors
MeSH PA D007166 Immunosuppressive Agents
MeSH PA D009676 Noxae
FDA EPC N0000175712 Purine Antimetabolite

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Refractory idiopathic thrombocytopenic purpura indication 13172003
Relapsing multiple sclerosis indication 24700007 DOID:2377
Crohn's disease indication 34000006
Pemphigus vulgaris indication 49420001 DOID:0060851
Systemic lupus erythematosus indication 55464009 DOID:9074
Ulcerative colitis indication 64766004 DOID:8577
Rheumatoid arthritis indication 69896004 DOID:7148
Bullous pemphigoid indication 77090002 DOID:8506
Myasthenia gravis indication 91637004 DOID:437
Polyarteritis nodosa indication 155441006 DOID:9810
Behcet's disease indication 310701003 DOID:13241
Dermatomyositis indication 396230008 DOID:10223
Autoimmune hepatitis indication 408335007
Refractory autoimmune haemolytic anaemia indication 413603009 DOID:718
Prevention of Kidney Transplant Rejection indication
Polymyositis off-label use 31384009
Prevention of Lung Transplant Rejection off-label use
Prevention of Cardiac Transplant Rejection off-label use
Prevention of Liver Transplant Rejection off-label use
Mycosis contraindication 3218000 DOID:1564
Viral disease contraindication 34014006 DOID:934
Hepatic vein thrombosis contraindication 38739001 DOID:11512
Bacterial infectious disease contraindication 87628006
Malignant lymphoma contraindication 118600007 DOID:0060058
Liver function tests abnormal contraindication 166603001
Acute pancreatitis contraindication 197456007 DOID:2913
Impaired renal function disorder contraindication 197663003
Anemia contraindication 271737000 DOID:2355
Pregnancy, function contraindication 289908002
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Bone marrow depression contraindication 307762000
Hepatosplenic T-cell lymphoma contraindication 445406001
Thiopurine S-Methyltransferase Deficiency contraindication
Severe Leukopenia contraindication
Protozoal Infection contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.28 acidic
pKa2 3.24 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
ATP-binding cassette sub-family G member 2 Transporter WOMBAT-PK
Multidrug resistance-associated protein 5 Transporter WOMBAT-PK
Multidrug resistance-associated protein 4 Transporter WOMBAT-PK
Ras-related C3 botulinum toxin substrate 1 Enzyme WOMBAT-PK
Thiopurine S-methyltransferase Enzyme WOMBAT-PK

External reference:

IDSource
4018766 VUID
N0000147069 NUI
D00238 KEGG_DRUG
1256 RXNORM
4018766 VANDF
C0004482 UMLSCUI
CHEMBL1542 ChEMBL_ID
DB00993 DRUGBANK_ID
D001379 MESH_DESCRIPTOR_UI
2265 PUBCHEM_CID
7120 IUPHAR_LIGAND_ID
1291 INN_ID
55774-33-9 SECONDARY_CAS_RN
MRK240IY2L UNII
3341 MMSL
4234 MMSL
4235 MMSL
6041 MMSL
d00024 MMSL
003419 NDDF
004123 NDDF
111165009 SNOMEDCT_US
372574004 SNOMEDCT_US
67221004 SNOMEDCT_US
CHEMBL1200400 ChEMBL_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Azathioprine Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0143-9566 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 100 mg INTRAVENOUS ANDA 22 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 0378-1005 TABLET 50 mg ORAL ANDA 23 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 21695-484 TABLET 50 mg ORAL ANDA 20 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 33261-758 TABLET 50 mg ORAL ANDA 20 sections
AZATHIOPRINE HUMAN PRESCRIPTION DRUG LABEL 1 42291-071 TABLET 50 mg ORAL ANDA 19 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 43353-745 TABLET 50 mg ORAL ANDA 23 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 51407-182 TABLET 50 mg ORAL ANDA 14 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 51407-182 TABLET 50 mg ORAL ANDA 14 sections
IMURAN HUMAN PRESCRIPTION DRUG LABEL 1 54766-590 TABLET 50 mg ORAL NDA 23 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 54868-5310 TABLET 50 mg ORAL ANDA 20 sections
AZATHIOPRINE HUMAN PRESCRIPTION DRUG LABEL 1 60219-1076 TABLET 50 mg ORAL ANDA 19 sections
AZATHIOPRINE HUMAN PRESCRIPTION DRUG LABEL 1 60219-2036 TABLET 75 mg ORAL ANDA 19 sections
AZATHIOPRINE HUMAN PRESCRIPTION DRUG LABEL 1 60219-2037 TABLET 100 mg ORAL ANDA 19 sections
IMURAN HUMAN PRESCRIPTION DRUG LABEL 1 65483-590 TABLET 50 mg ORAL NDA 23 sections
Azasan HUMAN PRESCRIPTION DRUG LABEL 1 65649-231 TABLET 75 mg ORAL ANDA 13 sections
Azasan HUMAN PRESCRIPTION DRUG LABEL 1 65649-241 TABLET 100 mg ORAL ANDA 13 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 65841-602 TABLET 50 mg ORAL ANDA 1 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 65841-602 TABLET 50 mg ORAL ANDA 1 sections
Azathioprine Human Prescription Drug Label 1 67877-492 TABLET 25 mg ORAL ANDA 21 sections
Azathioprine Human Prescription Drug Label 1 67877-492 TABLET 25 mg ORAL ANDA 21 sections
Azathioprine Human Prescription Drug Label 1 67877-493 TABLET 50 mg ORAL ANDA 21 sections
Azathioprine Human Prescription Drug Label 1 67877-493 TABLET 50 mg ORAL ANDA 21 sections
Azathioprine Human Prescription Drug Label 1 67877-494 TABLET 75 mg ORAL ANDA 21 sections
Azathioprine Human Prescription Drug Label 1 67877-494 TABLET 75 mg ORAL ANDA 21 sections
Azathioprine Human Prescription Drug Label 1 67877-495 TABLET 100 mg ORAL ANDA 21 sections
Azathioprine Human Prescription Drug Label 1 67877-495 TABLET 100 mg ORAL ANDA 21 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 68084-229 TABLET 50 mg ORAL ANDA 20 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 68084-229 TABLET 50 mg ORAL ANDA 20 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 68382-003 TABLET 50 1 ORAL ANDA 20 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 68382-003 TABLET 50 mg ORAL ANDA 20 sections