azathioprine ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
269 446-86-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • BW 57-322
  • azathioprine sulfate
  • azathioprine
  • azamune
  • azanin
  • azathioprin
  • azathropine
  • azothioprine
  • azathioprine sodium
Azathioprine is an inactive pro-drug of 6-mercaptopurine (6-MP), which acts as a purine antagonist but requires cellular uptake and intracellular anabolism to thioguanine nucleotides (TGNs) for immunosuppression. TGNs and other metabolites (e.g. 6-methylmercaptopurine ribonucleotides) inhibit de novo purine synthesis and purine nucleotide interconversions. The TGNs are also incorporated into nucleic acids and this contributes to the immunosuppressive effects of the medicinal product. Other potential mechanisms of azathioprine include the inhibition of many pathways in nucleic acid biosynthesis, hence preventing proliferation and activity of cells involved in the immune response (B and T lymphocytes). Because of these mechanisms, the therapeutic effect of azathioprine may be evident only after several weeks or months of treatment. Unlike 6-MP, the activity of the azathioprine metabolite 1-methyl-4-nitro-5-thioimidazole has not been clearly determined. However, compared with 6-MP it appears to modify the activity of azathioprine in several systems. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
  • Molecular weight: 277.26
  • Formula: C9H7N7O2S
  • CLOGP: 0.51
  • LIPINSKI: 0
  • HAC: 9
  • HDO: 1
  • TPSA: 115.42
  • ALOGS: -2.41
  • ROTB: 3

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.15 g O
0.15 g P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 10 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 1 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 18.03 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 60 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
March 20, 1968 FDA PROMETHEUS LABS
Feb. 21, 2019 PMDA ASPEN JAPAN K.K.; MITSUBISHI TANABE PHARMA CORPORATION

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Off label use 753.94 9.94 3383 147798 671079 62666762
Blood iron abnormal 607.39 9.94 257 150924 3619 63334222
Drug ineffective 585.34 9.94 4359 146822 1040406 62297435
Exposure during pregnancy 523.04 9.94 1148 150033 154399 63183442
Drug intolerance 418.84 9.94 1646 149535 307015 63030826
Treatment failure 400.77 9.94 1211 149970 197832 63140009
Colitis ulcerative 365.20 9.94 377 150804 25714 63312127
Condition aggravated 326.36 9.94 1847 149334 400370 62937471
Completed suicide 321.07 9.94 5 151176 145668 63192173
Premature delivery 299.33 9.94 365 150816 29916 63307925
Lupus-like syndrome 287.63 9.94 260 150921 15035 63322806
Bone erosion 284.77 9.94 276 150905 17441 63320400
Death 283.84 9.94 284 150897 374097 62963744
Cytomegalovirus infection 258.25 9.94 283 150898 20669 63317172
Fall 225.39 9.94 367 150814 391967 62945874
Therapeutic product effect incomplete 217.60 9.94 724 150457 124332 63213509
Intestinal stenosis 215.99 9.94 115 151066 2769 63335072
Drug level below therapeutic 215.52 9.94 138 151043 4728 63333113
Cushingoid 210.23 9.94 169 151012 8316 63329525
Anal fistula 204.17 9.94 119 151062 3432 63334409
Fistula 201.99 9.94 180 151001 10213 63327628
Product use in unapproved indication 197.93 9.94 898 150283 178182 63159659
Arthritis 194.49 9.94 663 150518 115258 63222583
Demyelination 193.42 9.94 148 151033 6772 63331069
Intentional product use issue 187.66 9.94 700 150481 127192 63210649
Red blood cell sedimentation rate increased 184.52 9.94 356 150825 43626 63294215
C-reactive protein increased 181.66 9.94 567 150614 94140 63243701
Joint dislocation 176.74 9.94 221 150960 18579 63319262
SLE arthritis 176.55 9.94 65 151116 616 63337225
Therapeutic response decreased 176.54 9.94 427 150754 61098 63276743
Transplant rejection 169.60 9.94 166 151015 10614 63327227
Exostosis 169.56 9.94 211 150970 17651 63320190
Rheumatoid arthritis 169.39 9.94 1109 150072 252710 63085131
Hepatic cirrhosis 168.99 9.94 249 150932 24485 63313356
Post transplant lymphoproliferative disorder 161.65 9.94 117 151064 4914 63332927
Fatigue 161.63 9.94 1348 149833 886680 62451161
Premature labour 161.26 9.94 173 151008 12331 63325510
Maternal exposure during pregnancy 155.09 9.94 975 150206 219087 63118754
Faecal calprotectin increased 154.79 9.94 96 151085 3107 63334734
Hyponatraemia 150.77 9.94 40 151141 111860 63225981
Ileal stenosis 150.39 9.94 76 151105 1637 63336204
Frequent bowel movements 149.04 9.94 226 150955 22796 63315045
Product dose omission issue 145.12 9.94 208 150973 234105 63103736
Inflammation 143.64 9.94 477 150704 81796 63256045
Toxicity to various agents 141.12 9.94 232 150949 247018 63090823
Pre-eclampsia 140.63 9.94 139 151042 8994 63328847
Joint stiffness 140.38 9.94 309 150872 41560 63296281
Malignant neoplasm progression 139.60 9.94 16 151165 82105 63255736
Disease recurrence 139.14 9.94 244 150937 27786 63310055
Drug hypersensitivity 138.48 9.94 1235 149946 309452 63028389
Epstein-Barr virus infection 138.06 9.94 130 151051 7920 63329921
Rheumatoid nodule 135.35 9.94 185 150996 16970 63320871
Elbow deformity 135.30 9.94 68 151113 1447 63336394
Proteinuria 134.07 9.94 195 150986 18950 63318891
Cholestasis of pregnancy 133.50 9.94 63 151118 1162 63336679
Crohn's disease 132.78 9.94 103 151078 4810 63333031
Retinitis 131.84 9.94 113 151068 6083 63331758
Intestinal resection 131.68 9.94 83 151098 2765 63335076
Osteoporosis 129.64 9.94 364 150817 56974 63280867
Confusional state 129.20 9.94 228 150953 236152 63101689
Somnolence 127.92 9.94 142 151039 178543 63159298
Impaired gastric emptying 124.61 9.94 138 151043 10194 63327647
Drug abuse 123.59 9.94 14 151167 72504 63265337
Diffuse large B-cell lymphoma 122.08 9.94 112 151069 6600 63331241
Pain 121.83 9.94 1153 150028 739475 62598366
Large intestinal stenosis 121.44 9.94 69 151112 1894 63335947
Abortion spontaneous 117.06 9.94 310 150871 46885 63290956
Basal cell carcinoma 116.69 9.94 226 150955 27765 63310076
Hypotension 116.44 9.94 302 150879 272302 63065539
Cytomegalovirus viraemia 116.10 9.94 101 151080 5548 63332293
Arthralgia 112.77 9.94 1943 149238 567767 62770074
Abscess 112.71 9.94 167 151014 16501 63321340
Haematochezia 112.41 9.94 331 150850 53213 63284628
Atrial fibrillation 110.03 9.94 71 151110 116565 63221276
Therapeutic product effect decreased 109.84 9.94 812 150369 192375 63145466
Constipation 109.82 9.94 232 150949 224711 63113130
Pancreatitis 109.50 9.94 310 150871 48745 63289096
Foot deformity 109.00 9.94 219 150962 27634 63310207
Anal abscess 105.80 9.94 88 151093 4544 63333297
Vasculitis 104.32 9.94 169 151012 18040 63319801
Electrocardiogram QT prolonged 102.69 9.94 11 151170 59519 63278322
Ulcer 100.65 9.94 204 150977 25903 63311938
Kidney transplant rejection 99.34 9.94 82 151099 4189 63333652
Cardiac failure congestive 99.10 9.94 48 151133 92385 63245456
Inappropriate schedule of product administration 98.54 9.94 499 150682 103466 63234375
Lupus nephritis 98.06 9.94 69 151112 2770 63335071
Abdominal pain 97.96 9.94 1099 150082 292357 63045484
Cerebrovascular accident 97.55 9.94 69 151112 107955 63229886
Glossodynia 96.38 9.94 174 151007 178702 63159139
Hypokalaemia 95.47 9.94 65 151116 103739 63234102
Tremor 94.72 9.94 105 151076 132134 63205707
Liver function test increased 93.32 9.94 227 150954 32584 63305257
Anal fissure 92.44 9.94 80 151101 4363 63333478
Antinuclear antibody positive 91.61 9.94 104 151077 7895 63329946
Drug level decreased 90.76 9.94 103 151078 7816 63330025
Febrile neutropenia 90.52 9.94 89 151092 118360 63219481
Dyspnoea 90.17 9.94 1075 150106 660238 62677603
Leukopenia 90.09 9.94 394 150787 76896 63260945
Contusion 90.09 9.94 136 151045 149908 63187933
Pleuritic pain 89.60 9.94 103 151078 7926 63329915
Ankylosing spondylitis 88.81 9.94 117 151064 10357 63327484
Normal newborn 88.07 9.94 104 151077 8237 63329604
Asthenia 87.96 9.94 544 150637 383060 62954781
Scleritis 86.65 9.94 77 151104 4351 63333490
Diarrhoea haemorrhagic 86.11 9.94 107 151074 8935 63328906
Haemophagocytic lymphohistiocytosis 84.43 9.94 115 151066 10512 63327329
Panniculitis 84.17 9.94 119 151062 11266 63326575
Intentional overdose 83.39 9.94 36 151145 74116 63263725
Erythema nodosum 82.21 9.94 78 151103 4797 63333044
Overdose 81.72 9.94 92 151089 114986 63222855
Pneumocystis jirovecii pneumonia 81.05 9.94 145 151036 16769 63321072
Clostridium difficile infection 79.80 9.94 202 150979 29720 63308121
Stomatitis 79.23 9.94 130 151051 138595 63199246
Product use issue 79.13 9.94 838 150343 219682 63118159
Synovial fluid analysis 79.12 9.94 57 151124 2376 63335465
Syncope 78.91 9.94 98 151083 117287 63220554
Hepatosplenic T-cell lymphoma 78.22 9.94 35 151146 568 63337273
Disseminated tuberculosis 77.24 9.94 60 151121 2807 63335034
Anaphylactic reaction 77.06 9.94 337 150844 65763 63272078
Neutrophil count decreased 76.27 9.94 20 151161 56386 63281455
Loss of consciousness 75.91 9.94 102 151079 118019 63219822
Tenosynovitis stenosans 74.95 9.94 63 151118 3301 63334540
Epstein-Barr virus associated lymphoproliferative disorder 74.80 9.94 50 151131 1844 63335997
Cardio-respiratory arrest 74.26 9.94 25 151156 59934 63277907
Pemphigus 72.80 9.94 211 150970 183515 63154326
Lung transplant rejection 72.35 9.94 38 151143 889 63336952
Swelling 72.00 9.94 374 150807 275004 63062837
Product label confusion 71.72 9.94 48 151133 1774 63336067
Intestinal obstruction 71.64 9.94 198 150983 30701 63307140
Uveitis 71.21 9.94 116 151065 12437 63325404
Musculoskeletal stiffness 71.17 9.94 712 150469 183906 63153935
Anti-neutrophil cytoplasmic antibody positive vasculitis 70.24 9.94 57 151124 2842 63334999
Aphthous ulcer 70.03 9.94 122 151059 13816 63324025
Sedation 70.03 9.94 6 151175 38803 63299038
Balance disorder 69.77 9.94 59 151122 84363 63253478
Colectomy 69.05 9.94 54 151127 2552 63335289
Granulomatosis with polyangiitis 68.98 9.94 51 151130 2214 63335627
Gestational hypertension 68.22 9.94 52 151129 2365 63335476
Angiocentric lymphoma 67.38 9.94 32 151149 599 63337242
Granuloma skin 66.57 9.94 91 151090 8346 63329495
Squamous cell carcinoma 66.45 9.94 92 151089 8540 63329301
Hair follicle tumour benign 65.60 9.94 28 151153 403 63337438
Seizure 65.35 9.94 136 151045 132498 63205343
Blood parathyroid hormone decreased 64.62 9.94 97 151084 9694 63328147
Device expulsion 64.12 9.94 5 151176 34917 63302924
Depressed level of consciousness 63.90 9.94 34 151147 62044 63275797
Premature baby 63.88 9.94 148 151033 20587 63317254
Muscle injury 62.68 9.94 39 151142 65306 63272535
Pancytopenia 62.36 9.94 420 150761 96513 63241328
Gastrointestinal lymphoma 62.28 9.94 17 151164 51 63337790
Platelet count decreased 61.59 9.94 114 151067 116008 63221833
Lymphoproliferative disorder 61.49 9.94 55 151126 3135 63334706
Skin ulcer 60.89 9.94 233 150948 42812 63295029
Progressive multifocal leukoencephalopathy 60.62 9.94 110 151071 12861 63324980
Immunosuppressant drug level decreased 59.98 9.94 34 151147 929 63336912
Dizziness 59.92 9.94 695 150486 429230 62908611
Pyoderma gangrenosum 59.23 9.94 57 151124 3568 63334273
Laryngitis 58.88 9.94 127 151054 16840 63321001
Anxiety 58.79 9.94 292 150889 217249 63120592
Osteonecrosis 58.67 9.94 159 151022 24371 63313470
Irritable bowel syndrome 58.38 9.94 66 151115 82346 63255495
Lupus vasculitis 58.15 9.94 28 151153 541 63337300
Gastrointestinal inflammation 57.64 9.94 69 151112 5543 63332298
C-reactive protein abnormal 57.57 9.94 240 150941 45856 63291985
Impaired work ability 57.46 9.94 128 151053 17347 63320494
Immunosuppressant drug level increased 57.18 9.94 56 151125 3582 63334259
Blood pressure fluctuation 56.95 9.94 240 150941 46077 63291764
Cardiac arrest 56.39 9.94 83 151098 92462 63245379
Live birth 56.24 9.94 161 151020 25469 63312372
Central nervous system lymphoma 55.38 9.94 38 151143 1464 63336377
Drug tolerance decreased 55.24 9.94 126 151055 17347 63320494
Blood glucose increased 55.16 9.94 71 151110 83685 63254156
Suicidal ideation 54.87 9.94 41 151140 62380 63275461
Tuberculosis 54.86 9.94 97 151084 11114 63326727
Bradycardia 54.81 9.94 56 151125 73171 63264670
Interstitial lung disease 54.38 9.94 291 150890 61617 63276224
Pulmonary fibrosis 54.28 9.94 213 150968 39596 63298245
Injection site erythema 54.27 9.94 71 151110 83103 63254738
Histoplasmosis disseminated 54.07 9.94 37 151144 1419 63336422
Intentional product misuse 53.56 9.94 40 151141 60877 63276964
Ileostomy 53.48 9.94 37 151144 1445 63336396
Discomfort 53.48 9.94 211 150970 167163 63170678
Coma 53.16 9.94 45 151136 64319 63273522
Depression 52.95 9.94 264 150917 196228 63141613
Diabetes mellitus 52.94 9.94 268 150913 55542 63282299
Agitation 52.85 9.94 39 151142 59718 63278123
Orthostatic hypotension 52.49 9.94 11 151170 36149 63301692
Premature separation of placenta 52.44 9.94 40 151141 1821 63336020
Pulmonary tuberculosis 52.19 9.94 59 151122 4458 63333383
Hallucination 52.18 9.94 33 151148 54784 63283057
Dehydration 51.98 9.94 224 150957 173130 63164711
Cytomegalovirus colitis 51.98 9.94 44 151137 2328 63335513
Overlap syndrome 51.44 9.94 30 151151 866 63336975
Wrong technique in product usage process 50.98 9.94 44 151137 62296 63275545
Metabolic acidosis 50.48 9.94 22 151159 45047 63292794
Hypogammaglobulinaemia 50.27 9.94 73 151108 7082 63330759
Skin necrosis 50.23 9.94 106 151075 13844 63323997
Lymphopenia 50.20 9.94 125 151056 18202 63319639
Autoimmune hepatitis 50.13 9.94 80 151101 8430 63329411
Tenosynovitis 49.88 9.94 105 151076 13690 63324151
Drug specific antibody present 49.84 9.94 56 151125 4203 63333638
Caesarean section 49.67 9.94 119 151062 16913 63320928
Hyperhidrosis 49.47 9.94 115 151066 107721 63230120
Bone pain 49.19 9.94 35 151146 54606 63283235
Injection site swelling 49.04 9.94 26 151155 47546 63290295
Joint swelling 48.76 9.94 1071 150110 326595 63011246
Back pain 48.56 9.94 399 150782 263746 63074095
Hypoglycaemia 48.38 9.94 43 151138 60022 63277819
Abdominal discomfort 47.72 9.94 511 150670 320374 63017467
Serotonin syndrome 47.72 9.94 6 151175 28676 63309165
Therapeutic product effect variable 47.61 9.94 32 151149 1191 63336650
Drug level above therapeutic 47.59 9.94 58 151123 4747 63333094
Suicide attempt 47.42 9.94 45 151136 60873 63276968
Mycobacterial infection 47.36 9.94 37 151144 1746 63336095
Neoplasm progression 47.23 9.94 14 151167 36414 63301427
Full blood count decreased 47.02 9.94 4 151177 26020 63311821
Clear cell renal cell carcinoma 46.49 9.94 34 151147 1451 63336390
Hyperkalaemia 45.87 9.94 37 151144 54166 63283675
Injection site inflammation 45.77 9.94 51 151130 3792 63334049
Listeriosis 45.76 9.94 34 151147 1487 63336354
Insomnia 45.32 9.94 313 150868 214939 63122902
Impaired healing 44.94 9.94 112 151069 102430 63235411
Blister 44.49 9.94 159 151022 129655 63208186
Premature rupture of membranes 44.24 9.94 57 151124 4936 63332905
Epstein-Barr virus test positive 44.22 9.94 24 151157 601 63337240
Multiple sclerosis relapse 43.70 9.94 31 151150 48447 63289394
Intentional self-injury 43.66 9.94 5 151176 25682 63312159
Wound 43.60 9.94 220 150961 163043 63174798
Chronic obstructive pulmonary disease 43.53 9.94 51 151130 62635 63275206
Chronic allograft nephropathy 43.45 9.94 25 151156 703 63337138
Episcleritis 43.39 9.94 28 151153 972 63336869
Intestinal fistula 43.33 9.94 27 151154 881 63336960
Dermatomyositis 43.21 9.94 43 151138 2805 63335036
Palmar-plantar erythrodysaesthesia syndrome 43.10 9.94 3 151178 23012 63314829
B-cell lymphoma 43.09 9.94 46 151135 3259 63334582
Folliculitis 42.89 9.94 63 151118 70254 63267587
Papilloma viral infection 42.61 9.94 33 151148 1537 63336304
Crepitations 42.53 9.94 72 151109 7968 63329873
Paraesthesia 42.21 9.94 211 150970 156755 63181086
Histoplasmosis 42.04 9.94 36 151145 1935 63335906
Therapeutic reaction time decreased 42.04 9.94 39 151142 2331 63335510
Injection site bruising 41.61 9.94 24 151157 41886 63295955
Respiratory arrest 41.50 9.94 13 151168 32632 63305209
Cognitive disorder 41.41 9.94 43 151138 55772 63282069
Neuropathy peripheral 41.13 9.94 136 151045 113531 63224310
Therapy interrupted 41.12 9.94 13 151168 32442 63305399
Adverse reaction 40.84 9.94 81 151100 10122 63327719
Hepatitis 40.53 9.94 195 150986 39593 63298248
Drug tolerance 40.49 9.94 65 151116 6884 63330957
Foetal growth restriction 40.43 9.94 68 151113 7485 63330356
Cardiac failure 40.14 9.94 96 151085 89046 63248795
Therapeutic response shortened 40.13 9.94 88 151093 11800 63326041
Drug ineffective for unapproved indication 39.94 9.94 174 151007 33889 63303952
Secondary immunodeficiency 39.58 9.94 30 151151 1353 63336488
Drug-induced liver injury 39.45 9.94 195 150986 40027 63297814
Pulmonary mass 39.39 9.94 131 151050 22465 63315376
Acute kidney injury 39.34 9.94 419 150762 262996 63074845
Nicotinic acid deficiency 39.15 9.94 12 151169 60 63337781
Device dislocation 39.04 9.94 7 151174 25698 63312143
Restlessness 38.77 9.94 11 151170 29442 63308399
Renal impairment 38.59 9.94 350 150831 88005 63249836
Renal mass 38.45 9.94 37 151144 2316 63335525
Accidental exposure to product 38.44 9.94 9 151172 27396 63310445
Lactic acidosis 37.91 9.94 22 151159 38265 63299576
Fungal endocarditis 37.69 9.94 16 151165 227 63337614
Wrist deformity 37.68 9.94 35 151146 2095 63335746
Abdominal abscess 37.51 9.94 50 151131 4476 63333365
Rectal discharge 37.45 9.94 22 151159 644 63337197
Cholangitis sclerosing 37.11 9.94 31 151150 1610 63336231
Aspergillus infection 37.02 9.94 68 151113 8025 63329816
Injection site pain 36.92 9.94 171 151010 129629 63208212
Fluid retention 36.87 9.94 53 151128 59633 63278208
Duodenal ulcer perforation 36.87 9.94 97 151084 87112 63250729
Dyskinesia 36.84 9.94 15 151166 31987 63305854
Squamous cell carcinoma of skin 36.61 9.94 58 151123 6074 63331767
Pneumonia cytomegaloviral 36.53 9.94 35 151146 2179 63335662
Splenic abscess 36.09 9.94 14 151167 155 63337686
Disseminated cytomegaloviral infection 35.98 9.94 15 151166 203 63337638
Muscle fatigue 35.77 9.94 37 151144 2527 63335314
Feeling abnormal 35.73 9.94 207 150974 148185 63189656
Laryngeal disorder 35.24 9.94 25 151156 1017 63336824
Urinary retention 35.21 9.94 14 151167 30287 63307554
White blood cell count decreased 35.15 9.94 191 150990 138913 63198928
Plasma cell myeloma 35.03 9.94 21 151160 35884 63301957
Medication error 34.76 9.94 44 151137 52240 63285601
Arthritis enteropathic 34.51 9.94 16 151165 283 63337558
Ear infection 34.50 9.94 181 151000 38032 63299809
Drug withdrawal syndrome 34.26 9.94 11 151170 27183 63310658
Abdominal adhesions 34.13 9.94 40 151141 3142 63334699
Nocardiosis 34.05 9.94 32 151149 1944 63335897
Myasthenia gravis 34.03 9.94 48 151133 4533 63333308
Low birth weight baby 34.01 9.94 61 151120 7068 63330773
Nausea 33.89 9.94 1677 149504 852794 62485047
Hypomagnesaemia 33.85 9.94 13 151168 28724 63309117
Mental status changes 33.54 9.94 27 151154 39572 63298269
Subcutaneous abscess 33.50 9.94 53 151128 5543 63332298
Small intestinal obstruction 33.48 9.94 108 151073 18229 63319612
Intestinal fibrosis 33.27 9.94 13 151168 147 63337694
Sinusitis 33.24 9.94 362 150819 226291 63111550
Jaw fracture 33.18 9.94 36 151145 2598 63335243
Klebsiella infection 33.09 9.94 67 151114 8499 63329342
Hand deformity 32.99 9.94 233 150948 159224 63178617
Epicondylitis 32.98 9.94 33 151148 2167 63335674
Immunosuppression 32.93 9.94 68 151113 8746 63329095
Myositis 32.89 9.94 70 151111 9196 63328645
Enterocutaneous fistula 32.86 9.94 27 151154 1370 63336471
Antiphospholipid syndrome 32.81 9.94 30 151151 1760 63336081
Blood calcium decreased 32.80 9.94 11 151170 26440 63311401
Synovial cyst 32.72 9.94 75 151106 10358 63327483
Anaemia 32.55 9.94 497 150684 292933 63044908
Plasmablastic lymphoma 32.46 9.94 14 151167 207 63337634
Dysgeusia 32.43 9.94 38 151143 46672 63291169
Ileectomy 32.43 9.94 13 151168 158 63337683
Product quality issue 32.24 9.94 23 151158 35842 63301999
Liver transplant rejection 32.23 9.94 27 151154 1408 63336433
Accidental overdose 32.02 9.94 8 151173 23301 63314540
Lipase increased 31.97 9.94 72 151109 9828 63328013
Decreased appetite 31.82 9.94 414 150767 250638 63087203
Abdominal pain upper 31.78 9.94 326 150855 206118 63131723
Osteoarthritis 31.68 9.94 357 150824 94986 63242855
Myasthenia gravis crisis 31.68 9.94 18 151163 494 63337347
Nasopharyngitis 31.59 9.94 421 150760 253836 63084005
Inflammatory bowel disease 31.57 9.94 43 151138 3930 63333911
Cardiac disorder 31.51 9.94 45 151136 50771 63287070
Coombs positive haemolytic anaemia 31.23 9.94 16 151165 355 63337486
Myocardial infarction 31.21 9.94 127 151054 99766 63238075
Disturbance in attention 31.16 9.94 27 151154 38162 63299679
Natural killer-cell leukaemia 31.08 9.94 11 151170 92 63337749
Nephrotic syndrome 30.92 9.94 51 151130 5525 63332316
Mucous stools 30.81 9.94 44 151137 4204 63333637
Sleep disorder due to general medical condition, insomnia type 30.67 9.94 48 151133 52169 63285672
Anaplastic large-cell lymphoma 30.57 9.94 11 151170 97 63337744
Polyomavirus viraemia 30.50 9.94 20 151161 714 63337127
Synovitis 30.35 9.94 619 150562 186299 63151542
Pregnancy 30.23 9.94 170 151011 36666 63301175
Bone marrow failure 30.16 9.94 144 151037 29146 63308695
Mycobacterium avium complex infection 30.14 9.94 37 151144 3051 63334790
Neutropenia 30.05 9.94 269 150912 174736 63163105
Unresponsive to stimuli 29.99 9.94 22 151159 33794 63304047
Mycobacterium abscessus infection 29.82 9.94 19 151162 645 63337196
Extrapulmonary tuberculosis 29.77 9.94 15 151166 321 63337520
Conjunctivitis 29.76 9.94 113 151068 20683 63317158
Sopor 29.69 9.94 8 151173 22156 63315685
Trichodysplasia spinulosa 29.68 9.94 18 151163 559 63337282
Lupus vulgaris 29.51 9.94 52 151129 5942 63331899
Thiopurine methyltransferase decreased 29.31 9.94 15 151166 332 63337509
Serum sickness 29.11 9.94 35 151146 2825 63335016
Emotional distress 29.09 9.94 21 151160 32528 63305313
Pulmonary embolism 29.04 9.94 161 151020 116523 63221318
Phospholipidosis 28.74 9.94 12 151169 163 63337678
Red blood cell sedimentation rate abnormal 28.73 9.94 108 151073 19674 63318167
Pneumatosis intestinalis 28.70 9.94 32 151149 2381 63335460
Heart transplant rejection 28.63 9.94 18 151163 597 63337244
Eye infection toxoplasmal 28.59 9.94 14 151167 281 63337560
Brain abscess 28.54 9.94 30 151151 2088 63335753
Rectal abscess 28.53 9.94 24 151157 1259 63336582
Antinuclear antibody negative 28.51 9.94 13 151168 221 63337620
Sleep apnoea syndrome 28.47 9.94 17 151164 29116 63308725
Cough 28.46 9.94 508 150673 292235 63045606
Creatinine renal clearance decreased 28.16 9.94 3 151178 16305 63321536
Transient ischaemic attack 28.10 9.94 29 151152 37724 63300117
Chorioretinopathy 28.07 9.94 20 151161 819 63337022
Acute febrile neutrophilic dermatosis 28.01 9.94 35 151146 2939 63334902
Eosinophilic granulomatosis with polyangiitis 27.69 9.94 30 151151 2162 63335679
Complications of bone marrow transplant 27.65 9.94 16 151165 455 63337386
Ganglioneuroma 27.64 9.94 11 151170 131 63337710
Pleural effusion 27.58 9.94 121 151060 93089 63244752
Fistula discharge 27.56 9.94 22 151159 1071 63336770
Pneumonia aspiration 27.49 9.94 25 151156 34515 63303326
Rectal cancer metastatic 27.39 9.94 13 151168 243 63337598
Allergy to chemicals 27.38 9.94 35 151146 3007 63334834
Vision blurred 26.79 9.94 120 151061 91804 63246037
Gastrointestinal haemorrhage 26.77 9.94 101 151080 81075 63256766
Hepatic fibrosis 26.74 9.94 38 151143 3614 63334227
Somatic delusion 26.74 9.94 17 151164 575 63337266
Flank pain 26.73 9.94 93 151088 16317 63321524
Scleroderma renal crisis 26.71 9.94 14 151167 326 63337515
Arthritis reactive 26.69 9.94 15 151166 403 63337438
Rheumatoid lung 26.65 9.94 39 151142 3809 63334032
Gastrointestinal wall thickening 26.65 9.94 24 151157 1380 63336461
Retinal toxicity 26.61 9.94 23 151158 1252 63336589
Nodular regenerative hyperplasia 26.59 9.94 16 151165 490 63337351
Sleep disorder 26.56 9.94 102 151079 81464 63256377
Neuromyelitis optica spectrum disorder 26.48 9.94 21 151160 1013 63336828
Tuberculosis of central nervous system 26.41 9.94 14 151167 334 63337507
Colitis 26.40 9.94 202 150979 48326 63289515
Hypocalcaemia 26.39 9.94 22 151159 31691 63306150
Joint effusion 26.34 9.94 95 151086 16965 63320876
Encephalopathy 26.19 9.94 32 151149 38588 63299253
Rhegmatogenous retinal detachment 26.17 9.94 10 151171 106 63337735
Foetal death 26.08 9.94 71 151110 10909 63326932
Poor venous access 26.02 9.94 86 151095 14699 63323142
Tonsillitis 26.00 9.94 48 151133 5687 63332154
Neoplasm malignant 25.97 9.94 140 151041 29721 63308120
Varicella zoster virus infection 25.89 9.94 32 151149 2657 63335184
Femur fracture 25.87 9.94 37 151144 41719 63296122
Memory impairment 25.87 9.94 144 151037 104114 63233727
Cervical dysplasia 25.86 9.94 35 151146 3179 63334662
Kaposi's sarcoma 25.86 9.94 11 151170 157 63337684
Dry skin 25.81 9.94 61 151120 56826 63281015
Anorectal disorder 25.78 9.94 26 151155 1723 63336118
Disorientation 25.40 9.94 34 151147 39418 63298423
Tractional retinal detachment 25.32 9.94 8 151173 45 63337796
Deep vein thrombosis 25.27 9.94 108 151073 83692 63254149
Colectomy total 25.18 9.94 11 151170 168 63337673
Renal transplant failure 25.12 9.94 18 151163 744 63337097
International normalised ratio increased 25.12 9.94 45 151136 46380 63291461
Gait disturbance 25.10 9.94 297 150884 182881 63154960
Meningitis cryptococcal 25.08 9.94 23 151158 1354 63336487
Muscular dystrophy 25.03 9.94 8 151173 47 63337794
Congenital osteodystrophy 24.94 9.94 7 151174 24 63337817
Aplasia pure red cell 24.82 9.94 41 151140 4446 63333395
Carcinoid tumour pulmonary 24.82 9.94 15 151166 463 63337378
Chronic hepatitis 24.68 9.94 19 151162 877 63336964
Rebound effect 24.56 9.94 41 151140 4485 63333356
Device issue 24.50 9.94 13 151168 23768 63314073
Glomerulosclerosis 24.42 9.94 14 151167 391 63337450
Faecal calprotectin abnormal 24.29 9.94 9 151172 87 63337754
Muscle spasms 24.26 9.94 246 150935 155904 63181937
HELLP syndrome 24.19 9.94 20 151161 1024 63336817
Peripheral swelling 24.13 9.94 467 150714 265475 63072366
Meningoencephalitis viral 23.97 9.94 13 151168 325 63337516
Thrombocytopenia 23.95 9.94 237 150944 150920 63186921
Lethargy 23.89 9.94 62 151119 55945 63281896
Thrombotic microangiopathy 23.81 9.94 67 151114 10494 63327347
Abscess intestinal 23.81 9.94 24 151157 1590 63336251
Congenital cytomegalovirus infection 23.69 9.94 6 151175 12 63337829
Anogenital warts 23.63 9.94 15 151166 506 63337335
Infectious mononucleosis 23.56 9.94 26 151155 1913 63335928
Vomiting 23.55 9.94 1091 150090 558526 62779315
Tuberculosis of eye 23.35 9.94 7 151174 32 63337809
Therapy non-responder 23.34 9.94 280 150901 75621 63262220
Pulmonary nocardiosis 23.31 9.94 13 151168 344 63337497
Atypical mycobacterial infection 23.28 9.94 20 151161 1080 63336761
Pulmonary oedema 23.21 9.94 61 151120 54812 63283029
Loss of therapeutic response 23.17 9.94 16 151165 623 63337218
Strongyloidiasis 23.04 9.94 21 151160 1227 63336614
Rectal stenosis 22.97 9.94 11 151170 210 63337631
Defaecation urgency 22.90 9.94 38 151143 4137 63333704
Abscess rupture 22.80 9.94 12 151169 282 63337559
Bronchitis 22.80 9.94 189 150992 124746 63213095
Macular degeneration 22.75 9.94 15 151166 24361 63313480
Foetal exposure during pregnancy 22.68 9.94 142 151039 31820 63306021
Kidney fibrosis 22.47 9.94 25 151156 1856 63335985
Poisoning 22.47 9.94 3 151178 13697 63324144
Weber tuning fork test abnormal 22.41 9.94 9 151172 110 63337731
Mucosal inflammation 22.36 9.94 49 151132 46879 63290962
T-cell lymphoma 22.36 9.94 16 151165 660 63337181
Delirium 22.30 9.94 55 151126 50486 63287355
Small intestinal stenosis 22.14 9.94 15 151166 566 63337275
Adverse drug reaction 21.92 9.94 288 150893 79426 63258415
Antisynthetase syndrome 21.90 9.94 8 151173 74 63337767
Salmonellosis 21.86 9.94 20 151161 1174 63336667
Inappropriate antidiuretic hormone secretion 21.84 9.94 5 151176 15457 63322384
Pneumocystis jirovecii infection 21.77 9.94 22 151159 1462 63336379
Epistaxis 21.76 9.94 94 151087 72631 63265210
Bursitis infective 21.72 9.94 21 151160 1322 63336519
Contraindicated product administered 21.70 9.94 675 150506 216973 63120868
Body temperature fluctuation 21.69 9.94 27 151154 2258 63335583
Abnormal behaviour 21.66 9.94 12 151169 21414 63316427
Hydrops foetalis 21.52 9.94 15 151166 593 63337248
Congenital syphilitic osteochondritis 21.51 9.94 6 151175 20 63337821
Asthma 21.49 9.94 197 150984 127364 63210477
Diabetic ketoacidosis 21.44 9.94 11 151170 20494 63317347
Herpes simplex hepatitis 21.40 9.94 13 151168 405 63337436
Hyperglycaemia 21.40 9.94 42 151139 41825 63296016
Pruritus 21.28 9.94 677 150504 360776 62977065
Epstein-Barr virus associated lymphoma 21.24 9.94 14 151167 504 63337337
Intestinal mucosal hypertrophy 21.19 9.94 11 151170 251 63337590
Metastases to central nervous system 21.18 9.94 3 151178 13102 63324739
Atypical haemolytic uraemic syndrome 21.16 9.94 16 151165 719 63337122
Oesophageal squamous cell carcinoma 20.87 9.94 9 151172 133 63337708
Blood glucose decreased 20.80 9.94 12 151169 20940 63316901
Gastrointestinal scarring 20.71 9.94 12 151169 342 63337499
Anal cancer 20.62 9.94 14 151167 530 63337311
Food intolerance 20.61 9.94 32 151149 3293 63334548
Withdrawal syndrome 20.50 9.94 11 151170 19986 63317855
Ejection fraction decreased 20.50 9.94 14 151167 22318 63315523
Haematoma 20.46 9.94 32 151149 34788 63303053
Hip fracture 20.44 9.94 24 151157 29450 63308391
Porokeratosis 20.40 9.94 9 151172 141 63337700
Varicella 20.36 9.94 24 151157 1897 63335944
Cytomegalovirus hepatitis 20.34 9.94 12 151169 354 63337487
Obstructive airways disorder 20.34 9.94 12 151169 20687 63317154
Hepatosplenomegaly 20.33 9.94 28 151153 2586 63335255
Corynebacterium infection 20.27 9.94 14 151167 545 63337296
Intestinal anastomosis 20.18 9.94 13 151168 450 63337391
Actinomycotic skin infection 20.17 9.94 4 151177 0 63337841
Female genital tract fistula 20.12 9.94 51 151130 7508 63330333
Dysphonia 20.09 9.94 53 151128 47561 63290280
Infusion related reaction 20.06 9.94 744 150437 244777 63093064
Hot flush 20.06 9.94 59 151122 51100 63286741
Mouth ulceration 20.06 9.94 141 151040 32843 63304998
Cervix carcinoma 19.92 9.94 30 151151 3007 63334834
Sebaceous carcinoma 19.91 9.94 6 151175 28 63337813
Spinal cord infection 19.91 9.94 15 151166 670 63337171
Oral lichen planus 19.89 9.94 15 151166 671 63337170
Primary biliary cholangitis 19.87 9.94 19 151162 1180 63336661
Myelosuppression 19.85 9.94 110 151071 23593 63314248
Granuloma 19.85 9.94 43 151138 5718 63332123
Gastrointestinal fistula 19.83 9.94 13 151168 464 63337377
Melaena 19.72 9.94 26 151155 30339 63307502
Fistula of small intestine 19.69 9.94 12 151169 376 63337465
Skin lesion 19.67 9.94 133 151048 30588 63307253
Anaplastic large cell lymphoma T- and null-cell types 19.63 9.94 7 151174 60 63337781
Cholesteatoma 19.63 9.94 9 151172 155 63337686
Back injury 19.58 9.94 59 151122 9601 63328240
Eye pruritus 19.54 9.94 10 151171 18661 63319180
Small intestinal resection 19.53 9.94 13 151168 476 63337365
Lupus myocarditis 19.53 9.94 7 151174 61 63337780
Injection site mass 19.52 9.94 10 151171 18646 63319195
Helicobacter infection 19.46 9.94 135 151046 92650 63245191
Anal ulcer 19.36 9.94 14 151167 587 63337254
Chest discomfort 19.32 9.94 168 151013 109801 63228040
Cavernous sinus thrombosis 19.32 9.94 9 151172 161 63337680
Lung abscess 19.24 9.94 23 151158 1845 63335996
Hirsutism 19.23 9.94 20 151161 1375 63336466
Urinary incontinence 19.21 9.94 29 151152 31985 63305856
Cerebral toxoplasmosis 19.12 9.94 17 151164 961 63336880
Intestinal dilatation 19.06 9.94 22 151159 1700 63336141
Migraine 19.01 9.94 156 151025 103190 63234651
Abnormal faeces 18.99 9.94 41 151140 5439 63332402
Therapy cessation 18.85 9.94 27 151154 30430 63307411
Trichostasis spinulosa 18.84 9.94 5 151176 13 63337828
Rectal haemorrhage 18.81 9.94 189 150992 48841 63289000
Fear 18.79 9.94 7 151174 15759 63322082
Coronary artery disease 18.79 9.94 30 151151 32347 63305494
Enthesopathy 18.79 9.94 54 151127 8560 63329281
Tonsillar hypertrophy 18.78 9.94 17 151164 984 63336857
Oral pain 18.76 9.94 24 151157 28370 63309471
Aggression 18.71 9.94 17 151164 23481 63314360
Gastrointestinal stoma output abnormal 18.68 9.94 7 151174 70 63337771
External auditory canal atresia 18.59 9.94 7 151174 71 63337770
Dysarthria 18.43 9.94 47 151134 42664 63295177
Upper gastrointestinal haemorrhage 18.43 9.94 11 151170 18841 63319000
Photophobia 18.37 9.94 87 151094 17548 63320293
Underdose 18.36 9.94 23 151158 27433 63310408
Malignant polyp 18.32 9.94 9 151172 182 63337659
Depressed mood 18.31 9.94 43 151138 40148 63297693
Renal tubular atrophy 18.26 9.94 15 151166 761 63337080
Metastases to bone 18.22 9.94 14 151167 21005 63316836
Proctalgia 18.15 9.94 43 151138 6067 63331774
Hyperadrenocorticism 18.13 9.94 11 151170 342 63337499
Speech disorder 18.09 9.94 44 151137 40585 63297256
Transient hypogammaglobulinaemia of infancy 18.00 9.94 6 151175 41 63337800
Pyoderma 17.85 9.94 11 151170 352 63337489
Bowel movement irregularity 17.80 9.94 39 151142 5225 63332616
Hypervolaemia 17.77 9.94 25 151156 28388 63309453
Muscle rigidity 17.75 9.94 3 151178 11497 63326344
Campylobacter infection 17.73 9.94 17 151164 1059 63336782
Gestational diabetes 17.70 9.94 52 151129 8344 63329497
Lacrimation increased 17.56 9.94 14 151167 20617 63317224
Acute myocardial infarction 17.50 9.94 31 151150 32093 63305748
Actinic keratosis 17.47 9.94 26 151155 2578 63335263
Small intestine carcinoma 17.43 9.94 12 151169 465 63337376
Anastomotic stenosis 17.42 9.94 10 151171 280 63337561
Mitochondrial neurogastrointestinal encephalopathy 17.41 9.94 4 151177 4 63337837
Pseudoxanthoma elasticum-like syndrome 17.41 9.94 4 151177 4 63337837
Bone density decreased 17.40 9.94 75 151106 14537 63323304
Neoplasm skin 17.37 9.94 20 151161 1541 63336300
Head injury 17.24 9.94 24 151157 27372 63310469
Haematocrit decreased 17.20 9.94 43 151138 39297 63298544
Muscle twitching 17.18 9.94 13 151168 19655 63318186
Lymphadenopathy 17.12 9.94 153 151028 38305 63299536
Eye ulcer 17.09 9.94 11 151170 380 63337461
Bronchiectasis 17.08 9.94 80 151101 16062 63321779
Muscle spasticity 17.07 9.94 16 151165 21778 63316063
Pollakiuria 17.06 9.94 25 151156 27912 63309929
Lung infiltration 17.04 9.94 74 151107 14389 63323452
Headache 17.04 9.94 1288 149893 631953 62705888
Feeling hot 17.02 9.94 62 151119 50292 63287549
Dementia 16.96 9.94 12 151169 18782 63319059
Vertigo 16.96 9.94 79 151102 59808 63278033
Swollen tongue 16.86 9.94 36 151145 34764 63303077
Heart rate irregular 16.79 9.94 101 151080 22320 63315521
Throat cancer 16.78 9.94 13 151168 606 63337235
Rectal tenesmus 16.71 9.94 15 151166 859 63336982
Bronchomalacia 16.67 9.94 9 151172 223 63337618
Electrolyte imbalance 16.62 9.94 14 151167 20062 63317779
Aspergillosis oral 16.57 9.94 6 151175 54 63337787
Candida infection 16.55 9.94 120 151061 28231 63309610
Seronegative arthritis 16.54 9.94 32 151149 3927 63333914
Hallucination, auditory 16.49 9.94 5 151176 12819 63325022
Anorectal stenosis 16.48 9.94 5 151176 24 63337817
Mediastinal effusion 16.38 9.94 6 151175 56 63337785
Weight decreased 16.37 9.94 811 150370 275987 63061854
Nightmare 16.36 9.94 13 151168 19181 63318660
Retinal injury 16.24 9.94 9 151172 235 63337606
Blood potassium increased 16.12 9.94 12 151169 18297 63319544
Injection site warmth 16.11 9.94 8 151173 15187 63322654
Hypercalcaemia 16.03 9.94 119 151062 28203 63309638
Skin exfoliation 15.98 9.94 51 151130 43051 63294790
Dysplasia 15.91 9.94 15 151166 915 63336926
Visual impairment 15.86 9.94 286 150895 84160 63253681
Abortion missed 15.82 9.94 20 151161 1699 63336142
B-cell unclassifiable lymphoma high grade 15.80 9.94 4 151177 8 63337833
Device breakage 15.78 9.94 4 151177 11538 63326303
Polyhydramnios 15.71 9.94 23 151158 2248 63335593
Product storage error 15.67 9.94 8 151173 14948 63322893
Malignant melanoma 15.67 9.94 61 151120 11295 63326546
Myelitis 15.66 9.94 18 151163 1385 63336456
Anal stenosis 15.62 9.94 11 151170 442 63337399
Metastases to liver 15.60 9.94 20 151161 23619 63314222
Anaphylactic shock 15.59 9.94 20 151161 23613 63314228
Mucormycosis 15.57 9.94 26 151155 2845 63334996
Exercise tolerance increased 15.56 9.94 5 151176 30 63337811
Herpes simplex reactivation 15.55 9.94 12 151169 556 63337285
Opportunistic infection 15.51 9.94 21 151160 1908 63335933
Congenital bowing of long bones 15.50 9.94 6 151175 66 63337775
Skin fissures 15.46 9.94 4 151177 11384 63326457
Hypophagia 15.43 9.94 32 151149 31227 63306614
Lupus endocarditis 15.36 9.94 9 151172 262 63337579
Feeling jittery 15.36 9.94 68 151113 13335 63324506
Enterostomy 15.32 9.94 8 151173 185 63337656
Cystitis 15.30 9.94 73 151108 54918 63282923
Burning sensation 15.27 9.94 72 151109 54335 63283506
Skin laceration 15.21 9.94 19 151162 22689 63315152
Irritability 15.18 9.94 33 151148 31661 63306180
Bulimia nervosa 15.17 9.94 11 151170 463 63337378
Hepatitis viral 15.11 9.94 11 151170 466 63337375
Squamous cell carcinoma of the tongue 15.05 9.94 10 151171 365 63337476
Epidermodysplasia verruciformis 15.04 9.94 7 151174 125 63337716
Affect lability 14.98 9.94 4 151177 11147 63326694
Injection site pruritus 14.96 9.94 56 151125 45060 63292781
Sinus bradycardia 14.93 9.94 8 151173 14543 63323298
Acne conglobata 14.91 9.94 4 151177 11 63337830
Chorioretinitis 14.88 9.94 12 151169 593 63337248
Axial spondyloarthritis 14.84 9.94 10 151171 374 63337467
Proctitis 14.78 9.94 37 151144 5404 63332437
Pulmonary necrosis 14.74 9.94 7 151174 131 63337710
Product administration error 14.73 9.94 19 151162 22378 63315463
Adenocarcinoma of the cervix 14.68 9.94 8 151173 202 63337639
Small intestine operation 14.66 9.94 5 151176 37 63337804
Palatal ulcer 14.61 9.94 6 151175 78 63337763
Microsporidia infection 14.60 9.94 9 151172 288 63337553
Infusion site thrombosis 14.60 9.94 7 151174 134 63337707
Drug level abnormal 14.60 9.94 7 151174 134 63337707
Seasonal allergy 14.59 9.94 17 151164 20933 63316908
Impetigo 14.57 9.94 17 151164 1329 63336512
Hiatus hernia 14.53 9.94 18 151163 21576 63316265
American trypanosomiasis 14.47 9.94 6 151175 80 63337761
Abdominal symptom 14.47 9.94 10 151171 390 63337451
Symptom masked 14.46 9.94 13 151168 746 63337095
Spondylitis 14.43 9.94 32 151149 4322 63333519
Intestinal polyp 14.35 9.94 18 151163 1517 63336324
Stress at work 14.34 9.94 16 151165 1191 63336650
Gastrooesophageal reflux disease 14.30 9.94 152 151029 95487 63242354
Lymphoedema 14.26 9.94 5 151176 11687 63326154
Oedema 14.26 9.94 156 151025 97466 63240375
Cranial sutures widening 14.19 9.94 4 151177 14 63337827
Obliterative bronchiolitis 14.17 9.94 21 151160 2074 63335767
Tuberous sclerosis complex 14.14 9.94 6 151175 85 63337756
Complications of transplanted kidney 14.14 9.94 23 151158 2463 63335378
Anger 14.07 9.94 6 151175 12450 63325391
Hospitalisation 14.06 9.94 132 151049 84949 63252892
Restless legs syndrome 14.06 9.94 14 151167 18517 63319324
Haemorrhage in pregnancy 14.05 9.94 20 151161 1905 63335936
Blood potassium decreased 14.04 9.94 52 151129 41974 63295867
Adenocarcinoma of colon 14.01 9.94 23 151158 2481 63335360
DNA antibody 14.01 9.94 5 151176 43 63337798
Meningitis listeria 13.98 9.94 12 151169 647 63337194
Peritonitis 13.96 9.94 79 151102 17075 63320766
Oedema peripheral 13.94 9.94 344 150837 189167 63148674
Tongue disorder 13.93 9.94 56 151125 10524 63327317
Mesenteritis 13.88 9.94 9 151172 315 63337526
Ileostomy closure 13.78 9.94 8 151173 229 63337612
Anterograde amnesia 13.77 9.94 11 151170 536 63337305
Ureteral neoplasm 13.77 9.94 4 151177 16 63337825
Hyperthyroidism 13.73 9.94 9 151172 14664 63323177
Drug eruption 13.73 9.94 116 151065 28578 63309263
Blood bilirubin increased 13.73 9.94 44 151137 37096 63300745
Appendicitis 13.72 9.94 47 151134 8182 63329659
Complex regional pain syndrome 13.67 9.94 22 151159 2335 63335506
Amnesia 13.66 9.94 77 151104 55508 63282333
Cutaneous leishmaniasis 13.66 9.94 6 151175 93 63337748
Pyometra 13.66 9.94 6 151175 93 63337748
Hepatitis E 13.61 9.94 17 151164 1427 63336414
Mechanical ileus 13.60 9.94 11 151170 546 63337295
Antineutrophil cytoplasmic antibody increased 13.59 9.94 7 151174 157 63337684
Anal squamous cell carcinoma 13.59 9.94 10 151171 431 63337410
Blood sodium decreased 13.58 9.94 23 151158 24229 63313612
Cytomegalovirus mucocutaneous ulcer 13.58 9.94 4 151177 17 63337824
Lymphocytopenia neonatal 13.58 9.94 4 151177 17 63337824
Transaminases increased 13.56 9.94 124 151057 31243 63306598
Glomerulonephritis 13.53 9.94 19 151162 1787 63336054
Abnormal palmar/plantar creases 13.52 9.94 5 151176 48 63337793
Pericarditis 13.51 9.94 226 150955 131353 63206488
Abdominal pain lower 13.47 9.94 106 151075 25572 63312269
Polymyositis 13.45 9.94 19 151162 1797 63336044
Nervousness 13.44 9.94 34 151147 30945 63306896
Anovulatory cycle 13.44 9.94 7 151174 161 63337680
Tenderness 13.43 9.94 96 151085 22482 63315359
Osteomyelitis 13.43 9.94 107 151074 25913 63311928
Double stranded DNA antibody positive 13.39 9.94 9 151172 335 63337506
Delusion 13.24 9.94 6 151175 12011 63325830
Fasting 13.22 9.94 4 151177 19 63337822
Polyomavirus-associated nephropathy 13.19 9.94 19 151162 1829 63336012
Threatened labour 13.15 9.94 13 151168 841 63337000
Gingival hypertrophy 13.15 9.94 18 151163 1653 63336188
Exfoliative rash 13.12 9.94 24 151157 2823 63335018
Pancreatitis acute 13.09 9.94 110 151071 27056 63310785
Endocarditis noninfective 13.08 9.94 5 151176 53 63337788
Ventricular tachycardia 13.08 9.94 17 151164 19962 63317879
JC virus infection 13.08 9.94 20 151161 2031 63335810
Gastrointestinal motility disorder 13.07 9.94 34 151147 5085 63332756
Congenital toxoplasmosis 13.06 9.94 3 151178 3 63337838
Cafe au lait spots 13.05 9.94 4 151177 20 63337821
Subarachnoid haemorrhage 13.05 9.94 9 151172 14274 63323567
Intestinal anastomosis complication 13.03 9.94 8 151173 254 63337587
Legionella infection 13.02 9.94 10 151171 460 63337381
Failed induction of labour 13.02 9.94 9 151172 351 63337490
Tuberculin test positive 13.01 9.94 27 151154 3484 63334357
Dermatitis psoriasiform 12.98 9.94 21 151160 2238 63335603
Pelvic abscess 12.92 9.94 18 151163 1680 63336161
Perichondritis 12.92 9.94 5 151176 55 63337786
Sepsis neonatal 12.91 9.94 10 151171 466 63337375
Fear of injection 12.90 9.94 42 151139 7122 63330719
Blood cholesterol increased 12.89 9.94 304 150877 93728 63244113
Hypercholesterolaemia 12.85 9.94 91 151090 21243 63316598
Listeria sepsis 12.85 9.94 12 151169 723 63337118
Injection site haemorrhage 12.77 9.94 24 151157 24290 63313551
Maternal exposure during breast feeding 12.76 9.94 30 151151 4211 63333630
Adverse event 12.75 9.94 229 150952 67330 63270511
Precursor T-lymphoblastic lymphoma/leukaemia 12.74 9.94 4 151177 22 63337819
Pseudopolyposis 12.74 9.94 4 151177 22 63337819
Patent ductus arteriosus 12.72 9.94 30 151151 4220 63333621
Panic attack 12.67 9.94 21 151160 22310 63315531
Faecal calprotectin 12.60 9.94 3 151178 4 63337837
Microscopic polyangiitis 12.59 9.94 7 151174 184 63337657
Sciatica 12.54 9.94 131 151050 34193 63303648
Ear pain 12.52 9.94 44 151137 36074 63301767
Steatorrhoea 12.49 9.94 10 151171 489 63337352
Renal-limited thrombotic microangiopathy 12.46 9.94 5 151176 61 63337780
Neuropsychiatric lupus 12.46 9.94 7 151174 188 63337653
Lymphadenitis bacterial 12.44 9.94 4 151177 24 63337817
Mental disorder 12.40 9.94 27 151154 25892 63311949
Dyspepsia 12.39 9.94 170 151011 102026 63235815
Nephropathy toxic 12.34 9.94 50 151131 9429 63328412
Proctectomy 12.32 9.94 6 151175 119 63337722
Angina pectoris 12.30 9.94 34 151147 30044 63307797
Proctitis ulcerative 12.29 9.94 8 151173 282 63337559
Complement factor C4 decreased 12.29 9.94 8 151173 282 63337559
Hypovolaemia 12.29 9.94 5 151176 10668 63327173
Herpes virus infection 12.28 9.94 35 151146 5521 63332320
Pulmonary congestion 12.27 9.94 14 151167 17404 63320437
Acute respiratory distress syndrome 12.26 9.94 97 151084 23437 63314404
Infertility 12.23 9.94 12 151169 769 63337072
Gastrointestinal oedema 12.22 9.94 15 151166 1237 63336604
Multiple allergies 12.21 9.94 9 151172 13793 63324048
Respiratory gas exchange disorder 12.21 9.94 9 151172 389 63337452
Placental necrosis 12.17 9.94 4 151177 26 63337815
Infective pulmonary exacerbation of cystic fibrosis 12.16 9.94 3 151178 8814 63329027
Microtia 12.15 9.94 9 151172 392 63337449
Amniotic cavity infection 12.11 9.94 15 151166 1248 63336593
Germ cell cancer 12.10 9.94 5 151176 66 63337775
Complement factor C3 decreased 12.09 9.94 8 151173 290 63337551
Lung disorder 12.09 9.94 212 150969 62049 63275792
Pharyngeal oedema 12.07 9.94 9 151172 13712 63324129
Transplant dysfunction 12.07 9.94 32 151149 4840 63333001
Hallucination, visual 12.05 9.94 17 151164 19281 63318560
Lacrimal haemorrhage 12.04 9.94 4 151177 27 63337814
Muir-Torre syndrome 12.04 9.94 4 151177 27 63337814
Osteonecrosis of jaw 12.03 9.94 43 151138 35080 63302761
Myoclonus 12.02 9.94 12 151169 15856 63321985
Abnormal dreams 11.99 9.94 5 151176 10511 63327330
Intestinal operation 11.96 9.94 10 151171 520 63337321
Thymoma 11.88 9.94 7 151174 206 63337635
Calciphylaxis 11.83 9.94 24 151157 3048 63334793
Limb injury 11.81 9.94 27 151154 25450 63312391
Palpitations 11.81 9.94 193 150988 112577 63225264
Lymphocele 11.78 9.94 12 151169 805 63337036
Occult blood 11.76 9.94 15 151166 1286 63336555
Synovial disorder 11.74 9.94 19 151162 2026 63335815
Cholecystitis chronic 11.69 9.94 5 151176 10356 63327485
Mediastinal abscess 11.68 9.94 4 151177 30 63337811
Blood test abnormal 11.64 9.94 12 151169 15617 63322224
Type 1 diabetes mellitus 11.61 9.94 27 151154 3763 63334078
Anastomotic complication 11.60 9.94 6 151175 136 63337705
Procedural pain 11.58 9.94 21 151160 21548 63316293
Primary effusion lymphoma 11.53 9.94 3 151178 7 63337834
Cheilitis granulomatosa 11.53 9.94 3 151178 7 63337834
Eye infection fungal 11.52 9.94 6 151175 138 63337703
Mammoplasty 11.47 9.94 10 151171 551 63337290
Encephalitis cytomegalovirus 11.47 9.94 10 151171 551 63337290
Stoma site extravasation 11.46 9.94 8 151173 317 63337524
Biopsy muscle abnormal 11.46 9.94 4 151177 32 63337809
Histiocytic necrotising lymphadenitis 11.46 9.94 4 151177 32 63337809
Concussion 11.44 9.94 48 151133 9196 63328645
Scedosporium infection 11.44 9.94 10 151171 553 63337288
Immune-mediated myositis 11.38 9.94 15 151166 1328 63336513
Anuria 11.34 9.94 8 151173 12543 63325298
Central nervous system necrosis 11.25 9.94 6 151175 145 63337696
Disease risk factor 11.24 9.94 5 151176 80 63337761
Bronchiolitis 11.23 9.94 22 151159 2725 63335116
Cytopenia 11.20 9.94 56 151125 11545 63326296
Gastritis haemorrhagic 11.20 9.94 16 151165 1529 63336312
Injection site induration 11.16 9.94 4 151177 9222 63328619
Body height decreased 11.16 9.94 5 151176 10073 63327768
Hepatic infection bacterial 11.14 9.94 4 151177 35 63337806
Tricuspid valve incompetence 11.14 9.94 11 151170 14610 63323231
Dyspnoea exertional 11.10 9.94 91 151090 60211 63277630
Electrocardiogram abnormal 11.07 9.94 4 151177 9175 63328666
Drug specific antibody 11.04 9.94 20 151161 2335 63335506
Q fever 11.03 9.94 6 151175 151 63337690
Haemorrhage foetal 10.99 9.94 3 151178 9 63337832
Arrhythmia 10.98 9.94 50 151131 38090 63299751
Rash erythematous 10.93 9.94 58 151123 42452 63295389
Nerve injury 10.91 9.94 5 151176 9941 63327900
Acinetobacter infection 10.90 9.94 16 151165 1567 63336274
Salmonella bacteraemia 10.89 9.94 6 151175 155 63337686
IgA nephropathy 10.82 9.94 10 151171 595 63337246
Superinfection 10.80 9.94 21 151160 2586 63335255
Stillbirth 10.77 9.94 38 151143 6712 63331129
Cytomegalovirus chorioretinitis 10.76 9.94 17 151164 1776 63336065
Enterococcal sepsis 10.75 9.94 15 151166 1403 63336438
Taste disorder 10.74 9.94 10 151171 13652 63324189
Pseudomonas infection 10.74 9.94 54 151127 11159 63326682
DNA antibody positive 10.71 9.94 8 151173 353 63337488
Altered state of consciousness 10.71 9.94 28 151153 25202 63312639
Cervical incompetence 10.65 9.94 10 151171 607 63337234
Fibroadenoma of breast 10.63 9.94 9 151172 476 63337365
Intra-abdominal fluid collection 10.60 9.94 20 151161 2409 63335432
Nodule 10.60 9.94 86 151095 20940 63316901
Ileal ulcer 10.59 9.94 9 151172 479 63337362
Epiglottic erythema 10.59 9.94 4 151177 41 63337800
Mobility decreased 10.58 9.94 370 150811 120789 63217052
Urosepsis 10.58 9.94 78 151103 18446 63319395
Perirectal abscess 10.57 9.94 12 151169 911 63336930
Microangiopathic haemolytic anaemia 10.57 9.94 10 151171 613 63337228
Complication associated with device 10.56 9.94 15 151166 16963 63320878
Enterobacter infection 10.55 9.94 19 151162 2208 63335633
Hypoglycaemic seizure 10.52 9.94 9 151172 483 63337358
Oxygen saturation decreased 10.51 9.94 148 151033 88437 63249404
Coloboma 10.51 9.94 5 151176 94 63337747
Sneezing 10.46 9.94 17 151164 18201 63319640
Limb discomfort 10.44 9.94 36 151145 29680 63308161
Mucosal necrosis 10.42 9.94 4 151177 43 63337798
Cytomegalovirus oesophagitis 10.40 9.94 7 151174 261 63337580
Cleft lip and palate 10.40 9.94 10 151171 625 63337216
Complications of transplanted lung 10.38 9.94 7 151174 262 63337579
Conjunctivitis allergic 10.37 9.94 12 151169 930 63336911
Knee arthroplasty 10.34 9.94 81 151100 54125 63283716
Pulmonary venous thrombosis 10.33 9.94 3 151178 12 63337829
Meningitis aseptic 10.29 9.94 30 151151 4793 63333048
Pouchitis 10.29 9.94 9 151172 498 63337343
Ill-defined disorder 10.27 9.94 135 151046 81620 63256221
Gastroenteritis norovirus 10.26 9.94 18 151163 2050 63335791
Sinonasal papilloma 10.26 9.94 4 151177 45 63337796
Hepatotoxicity 10.25 9.94 134 151047 36907 63300934
Torsade de pointes 10.23 9.94 10 151171 13341 63324500
Hypoxia 10.21 9.94 92 151089 59700 63278141
Varicella zoster pneumonia 10.18 9.94 4 151177 46 63337795
Dysstasia 10.17 9.94 22 151159 21144 63316697
Neutrophilic dermatosis 10.14 9.94 6 151175 178 63337663
Renal phospholipidosis 10.14 9.94 5 151176 102 63337739
Hodgkin's disease stage II 10.14 9.94 3 151178 13 63337828
Intestinal fistula infection 10.14 9.94 3 151178 13 63337828
Tinnitus 10.09 9.94 47 151134 35581 63302260
Product substitution issue 10.08 9.94 14 151167 15982 63321859
Hypergammaglobulinaemia 10.08 9.94 9 151172 512 63337329
Bacillary angiomatosis 10.05 9.94 5 151176 104 63337737
Bedridden 10.05 9.94 7 151174 11044 63326797
Cardiogenic shock 10.05 9.94 17 151164 17915 63319926
Staphylococcal skin infection 10.03 9.94 12 151169 963 63336878
Tracheal disorder 10.01 9.94 7 151174 278 63337563
Large intestinal ulcer 9.97 9.94 24 151157 3420 63334421
Ubiquinone decreased 9.96 9.94 3 151178 14 63337827
Pseudopolyp 9.95 9.94 7 151174 281 63337560

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Off label use 548.70 11.11 2102 75547 417422 34461860
Colitis ulcerative 483.47 11.11 353 77296 16167 34863115
Drug ineffective 464.17 11.11 2119 75530 454632 34424650
Death 320.99 11.11 250 77399 397799 34481483
Intentional product use issue 319.26 11.11 517 77132 59299 34819983
Hepatosplenic T-cell lymphoma 276.91 11.11 82 77567 388 34878894
Drug eruption 268.61 11.11 273 77376 19625 34859657
Nodular regenerative hyperplasia 259.07 11.11 93 77556 880 34878402
Therapeutic product effect decreased 234.41 11.11 335 77314 34408 34844874
Intestinal stenosis 228.84 11.11 107 77542 2079 34877203
Fistula 224.98 11.11 157 77492 6683 34872599
Condition aggravated 216.40 11.11 922 76727 191274 34688008
Epstein-Barr virus infection 211.84 11.11 158 77491 7470 34871812
Inappropriate schedule of product administration 211.45 11.11 443 77206 61853 34817429
Post transplant lymphoproliferative disorder 205.79 11.11 146 77503 6382 34872900
Drug abuse 204.54 11.11 3 77646 99093 34780189
Treatment failure 193.36 11.11 361 77288 46336 34832946
Frequent bowel movements 186.48 11.11 183 77466 12604 34866678
Cytomegalovirus infection 185.14 11.11 258 77391 25877 34853405
Anal abscess 181.81 11.11 135 77514 6338 34872944
Lymphoproliferative disorder 174.32 11.11 96 77553 2663 34876619
Hypersensitivity 172.07 11.11 403 77246 60632 34818650
Completed suicide 168.67 11.11 13 77636 98155 34781127
Product use issue 157.49 11.11 398 77251 62818 34816464
Diffuse large B-cell lymphoma 155.82 11.11 130 77519 7240 34872042
Febrile neutropenia 148.64 11.11 59 77590 136790 34742492
Ileal stenosis 145.80 11.11 68 77581 1313 34877969
Anal fistula 143.62 11.11 109 77540 5290 34873992
Fall 142.98 11.11 144 77505 202741 34676541
Faecal calprotectin increased 140.36 11.11 81 77568 2463 34876819
Drug level below therapeutic 139.83 11.11 109 77540 5506 34873776
Hepatic function abnormal 139.55 11.11 306 77343 44057 34835225
Hypotension 136.98 11.11 175 77474 221474 34657808
Toxicity to various agents 133.58 11.11 149 77500 200213 34679069
Intestinal obstruction 130.88 11.11 204 77445 22618 34856664
Acute febrile neutrophilic dermatosis 124.81 11.11 60 77589 1243 34878039
Malignant neoplasm progression 121.42 11.11 24 77625 88022 34791260
Disseminated tuberculosis 121.10 11.11 70 77579 2135 34877147
Blood pressure fluctuation 120.85 11.11 208 77441 25041 34854241
Drug level decreased 117.59 11.11 114 77535 7732 34871550
Premature baby 117.49 11.11 179 77470 19454 34859828
Abscess 115.70 11.11 137 77512 11680 34867602
Crohn's disease 115.44 11.11 77 77572 3040 34876242
Disease recurrence 114.83 11.11 186 77463 21304 34857978
Squamous cell carcinoma 113.95 11.11 134 77515 11341 34867941
Cytomegalovirus colitis 113.41 11.11 73 77576 2711 34876571
Urticaria 106.74 11.11 343 77306 62034 34817248
Transplant rejection 106.72 11.11 123 77526 10188 34869094
Colitis 106.04 11.11 249 77400 37501 34841781
Infusion related reaction 103.09 11.11 305 77344 52752 34826530
Coombs positive haemolytic anaemia 103.05 11.11 48 77601 924 34878358
Pneumocystis jirovecii pneumonia 101.80 11.11 168 77481 19542 34859740
Dizziness 101.63 11.11 208 77441 218313 34660969
Acute kidney injury 97.68 11.11 349 77300 304639 34574643
Therapeutic response shortened 97.00 11.11 100 77549 7304 34871978
Somnolence 96.65 11.11 64 77585 111052 34768230
Drug specific antibody present 95.60 11.11 70 77579 3215 34876067
Large intestinal stenosis 94.82 11.11 53 77596 1514 34877768
Myocardial infarction 94.65 11.11 78 77571 121007 34758275
Hand deformity 94.25 11.11 73 77576 3652 34875630
Intestinal fistula 92.41 11.11 45 77604 960 34878322
Dyspnoea 90.90 11.11 480 77169 376302 34502980
Cushingoid 90.89 11.11 63 77586 2651 34876631
Pulmonary tuberculosis 90.57 11.11 79 77570 4675 34874607
JC virus infection 90.20 11.11 58 77591 2150 34877132
Haemophagocytic lymphohistiocytosis 88.77 11.11 126 77523 12847 34866435
Leukopenia 88.59 11.11 324 77325 62532 34816750
Atrial fibrillation 87.11 11.11 86 77563 122307 34756975
Stomatitis 87.00 11.11 249 77400 42265 34837017
Progressive multifocal leukoencephalopathy 85.51 11.11 107 77542 9657 34869625
Cardiac failure congestive 85.40 11.11 39 77610 83231 34796051
Lymphadenitis 84.65 11.11 54 77595 1974 34877308
Weight decreased 84.63 11.11 675 76974 175626 34703656
Night sweats 84.41 11.11 144 77505 17208 34862074
Pancytopenia 84.22 11.11 426 77223 94731 34784551
Intestinal resection 84.21 11.11 51 77598 1698 34877584
Product use in unapproved indication 83.82 11.11 496 77153 117003 34762279
Confusional state 83.69 11.11 119 77530 144041 34735241
Basal cell carcinoma 82.59 11.11 153 77496 19505 34859777
Nocardiosis 82.08 11.11 69 77580 3882 34875400
Epstein-Barr virus associated lymphoproliferative disorder 81.24 11.11 52 77597 1912 34877370
Erythema nodosum 78.55 11.11 45 77604 1349 34877933
Intentional overdose 77.24 11.11 5 77644 43669 34835613
Tuberculosis 76.73 11.11 95 77554 8482 34870800
Bradycardia 76.28 11.11 36 77613 75382 34803900
Diarrhoea haemorrhagic 75.63 11.11 84 77565 6680 34872602
Anal fissure 75.18 11.11 68 77581 4222 34875060
Colectomy 74.01 11.11 48 77601 1806 34877476
Kidney transplant rejection 73.52 11.11 87 77562 7410 34871872
Clear cell renal cell carcinoma 72.70 11.11 40 77609 1107 34878175
Haematochezia 72.54 11.11 248 77401 46286 34832996
Hyponatraemia 71.38 11.11 48 77601 82643 34796639
Weight increased 68.43 11.11 396 77253 92637 34786645
Defaecation urgency 68.26 11.11 52 77597 2537 34876745
Small intestinal stenosis 68.11 11.11 30 77619 504 34878778
Dehydration 68.04 11.11 115 77534 129854 34749428
Squamous cell carcinoma of skin 67.64 11.11 101 77548 10780 34868502
Human herpesvirus 8 infection 67.36 11.11 36 77613 939 34878343
Pemphigus 67.01 11.11 43 77606 1588 34877694
Epistaxis 66.46 11.11 281 77368 57970 34821312
Cytomegalovirus enteritis 66.34 11.11 29 77620 478 34878804
Drug intolerance 66.14 11.11 285 77364 59285 34819997
Cardiac arrest 65.64 11.11 70 77579 96089 34783193
Abdominal pain 65.60 11.11 602 77047 163016 34716266
Non-cirrhotic portal hypertension 64.63 11.11 24 77625 252 34879030
Cytomegalovirus viraemia 64.39 11.11 81 77568 7349 34871933
Epidermodysplasia verruciformis 62.76 11.11 23 77626 232 34879050
Product dose omission issue 62.59 11.11 106 77543 119605 34759677
Gastrointestinal inflammation 62.21 11.11 56 77593 3455 34875827
Therapeutic product effect incomplete 61.74 11.11 249 77400 50292 34828990
Herpes zoster 61.40 11.11 192 77457 34207 34845075
Lymphopenia 61.06 11.11 121 77528 16214 34863068
Portal hypertension 60.83 11.11 59 77590 4003 34875279
Fistula discharge 59.73 11.11 32 77617 839 34878443
Lung transplant rejection 59.71 11.11 31 77618 761 34878521
Cardio-respiratory arrest 59.66 11.11 24 77625 55249 34824033
Renal cell carcinoma 58.71 11.11 64 77585 4984 34874298
Histoplasmosis disseminated 58.65 11.11 37 77612 1326 34877956
T-cell lymphoma 58.25 11.11 33 77616 968 34878314
Plasmablastic lymphoma 58.00 11.11 24 77625 343 34878939
Neuropathy peripheral 57.51 11.11 60 77589 83203 34796079
Meningitis listeria 57.00 11.11 26 77623 476 34878806
Immunosuppression 56.67 11.11 70 77579 6234 34873048
Syncope 56.57 11.11 72 77577 91379 34787903
Pain in extremity 56.11 11.11 476 77173 126037 34753245
Blood glucose increased 55.89 11.11 40 77609 66678 34812604
Epstein-Barr virus associated lymphoma 55.74 11.11 28 77621 640 34878642
Heart transplant rejection 54.44 11.11 34 77615 1197 34878085
Muscle spasms 54.32 11.11 318 77331 74683 34804599
Overdose 53.97 11.11 74 77575 90985 34788297
B-cell lymphoma 53.70 11.11 57 77592 4306 34874976
Rebound effect 53.68 11.11 50 77599 3224 34876058
Aspergillus infection 53.52 11.11 97 77552 12157 34867125
Drug level above therapeutic 53.03 11.11 56 77593 4205 34875077
Transplant dysfunction 52.44 11.11 45 77604 2604 34876678
Arthralgia 51.14 11.11 590 77059 169451 34709831
Kaposi's sarcoma 51.08 11.11 29 77620 854 34878428
Epstein-Barr virus test positive 50.72 11.11 25 77624 548 34878734
Rheumatoid factor negative 50.60 11.11 29 77620 870 34878412
Abdominal adhesions 50.38 11.11 35 77614 1478 34877804
Loss of consciousness 50.18 11.11 66 77583 82601 34796681
Decreased appetite 50.11 11.11 195 77454 166197 34713085
Aggression 48.94 11.11 13 77636 38951 34840331
Inflammatory bowel disease 48.66 11.11 45 77604 2875 34876407
Chronic obstructive pulmonary disease 48.46 11.11 24 77625 48894 34830388
Oedema peripheral 48.33 11.11 123 77526 119689 34759593
Hypoglycaemia 48.11 11.11 31 77618 54609 34824673
Clostridium difficile infection 48.06 11.11 120 77529 18778 34860504
Acute myocardial infarction 47.96 11.11 30 77619 53689 34825593
Delirium 47.64 11.11 19 77630 43972 34835310
Low birth weight baby 47.18 11.11 72 77577 7833 34871449
Drug ineffective for unapproved indication 46.67 11.11 137 77512 23578 34855704
Intestinal perforation 46.47 11.11 77 77572 8983 34870299
Chronic allograft nephropathy 46.42 11.11 31 77618 1226 34878056
Cerebrovascular accident 46.27 11.11 73 77576 84738 34794544
Cardiac failure 45.68 11.11 83 77566 91165 34788117
Polyhydramnios 45.52 11.11 18 77631 227 34879055
Food intolerance 45.02 11.11 32 77617 1402 34877880
Hypokalaemia 44.83 11.11 38 77611 58176 34821106
Therapeutic response decreased 44.60 11.11 155 77494 29158 34850124
Plasma cell myeloma 44.16 11.11 19 77630 42018 34837264
Pneumonia aspiration 43.92 11.11 19 77630 41884 34837398
Electrocardiogram QT prolonged 43.84 11.11 18 77631 40934 34838348
Ileostomy 43.53 11.11 24 77625 667 34878615
Gastrointestinal haemorrhage 42.94 11.11 82 77567 88395 34790887
Coma 42.90 11.11 24 77625 45654 34833628
International normalised ratio increased 42.84 11.11 26 77623 47301 34831981
Neutrophil count decreased 42.32 11.11 31 77618 51073 34828209
Anal stenosis 42.02 11.11 16 77633 181 34879101
Small intestinal obstruction 41.65 11.11 98 77551 14768 34864514
Lymphocytopenia neonatal 41.42 11.11 9 77640 6 34879276
Vasculitis 41.41 11.11 83 77566 11213 34868069
Foetal exposure during pregnancy 41.28 11.11 181 77468 37920 34841362
Abscess intestinal 41.08 11.11 32 77617 1614 34877668
Abnormal behaviour 40.96 11.11 4 77645 24965 34854317
Peliosis hepatis 40.48 11.11 12 77637 57 34879225
Extrapulmonary tuberculosis 40.38 11.11 13 77636 85 34879197
Lymphoma 40.12 11.11 87 77562 12420 34866862
Wrong technique in product usage process 39.87 11.11 15 77634 35971 34843311
Hepatitis 39.54 11.11 130 77519 23774 34855508
Cytokine release syndrome 39.34 11.11 3 77646 22874 34856408
Pancreatitis 39.32 11.11 181 77468 38710 34840572
Hallucination 39.18 11.11 34 77615 51464 34827818
Histoplasmosis 38.95 11.11 30 77619 1488 34877794
Urinary retention 38.76 11.11 16 77633 36272 34843010
Depressed level of consciousness 38.13 11.11 24 77625 42817 34836465
Respiratory arrest 37.89 11.11 8 77641 28035 34851247
Proctocolectomy 37.70 11.11 13 77636 108 34879174
Tachycardia 37.38 11.11 83 77566 84689 34794593
Agitation 36.73 11.11 44 77605 57355 34821927
Asthenia 36.70 11.11 358 77291 244893 34634389
Cholangitis sclerosing 36.28 11.11 28 77621 1393 34877889
Heart rate decreased 36.08 11.11 153 77496 31592 34847690
Hospitalisation 36.01 11.11 44 77605 56858 34822424
Rectal fissure 35.90 11.11 17 77632 340 34878942
Orthostatic hypotension 35.84 11.11 7 77642 25912 34853370
Disease progression 35.58 11.11 122 77527 107955 34771327
Combined immunodeficiency 35.55 11.11 11 77638 62 34879220
Pulmonary vasculitis 35.54 11.11 20 77629 579 34878703
Candida infection 35.49 11.11 103 77546 17612 34861670
Musculoskeletal discomfort 35.40 11.11 64 77585 8004 34871278
Visceral leishmaniasis 35.14 11.11 20 77629 592 34878690
Rectal abscess 34.67 11.11 27 77622 1361 34877921
Mycobacterial infection 34.65 11.11 34 77615 2340 34876942
Enterocutaneous fistula 34.60 11.11 24 77625 1011 34878271
Varicella zoster virus infection 34.38 11.11 30 77619 1776 34877506
Cutaneous T-cell lymphoma 34.32 11.11 28 77621 1510 34877772
Foetal growth restriction 34.28 11.11 44 77605 4073 34875209
Eosinophilic granulomatosis with polyangiitis 33.85 11.11 31 77618 1956 34877326
Heart rate irregular 33.70 11.11 94 77555 15713 34863569
Herpes simplex 33.69 11.11 51 77598 5508 34873774
Accidental overdose 33.64 11.11 3 77646 20137 34859145
Phaeohyphomycosis 33.58 11.11 22 77627 842 34878440
Bone erosion 33.57 11.11 43 77606 3972 34875310
Splenomegaly 33.32 11.11 91 77558 15026 34864256
Disorientation 33.30 11.11 16 77633 33172 34846110
Serotonin syndrome 33.21 11.11 3 77646 19930 34859352
Unresponsive to stimuli 33.13 11.11 10 77639 27559 34851723
Dysgeusia 32.97 11.11 9 77640 26488 34852794
Neuroendocrine carcinoma of the skin 32.86 11.11 21 77628 770 34878512
Obliterative bronchiolitis 32.67 11.11 25 77624 1228 34878054
Hepatic enzyme increased 32.47 11.11 172 77477 38908 34840374
Granuloma 32.33 11.11 38 77611 3213 34876069
Lupus-like syndrome 32.15 11.11 35 77614 2721 34876561
Myasthenia gravis crisis 32.05 11.11 19 77630 608 34878674
Balance disorder 31.96 11.11 26 77623 40628 34838654
White blood cell count decreased 31.91 11.11 107 77542 95338 34783944
Gait disturbance 31.61 11.11 91 77558 85049 34794233
Haemolysis 31.51 11.11 61 77588 8033 34871249
Seizure 31.46 11.11 123 77526 104734 34774548
Transient ischaemic attack 31.45 11.11 11 77638 27602 34851680
Gastrointestinal disorder 31.41 11.11 154 77495 33794 34845488
Red blood cell sedimentation rate abnormal 30.90 11.11 39 77610 3550 34875732
Anxiety 30.88 11.11 115 77534 99313 34779969
Chronic gastrointestinal bleeding 30.84 11.11 15 77634 319 34878963
Mycoplasma infection 30.73 11.11 16 77633 395 34878887
Hypocalcaemia 30.70 11.11 8 77641 24281 34855001
Metabolic acidosis 30.68 11.11 31 77618 43649 34835633
Limb deformity 30.41 11.11 18 77631 574 34878708
Body temperature fluctuation 30.35 11.11 27 77622 1640 34877642
Therapeutic reaction time decreased 30.32 11.11 24 77625 1239 34878043
Intestinal anastomosis 30.31 11.11 14 77635 264 34879018
Drug tolerance decreased 30.26 11.11 29 77620 1938 34877344
Contusion 30.18 11.11 22 77627 36342 34842940
Bronchopulmonary aspergillosis 30.10 11.11 86 77563 14573 34864709
Arthropathy 30.04 11.11 129 77520 26778 34852504
Irritability 29.59 11.11 9 77640 24681 34854601
Gastrointestinal stenosis 29.58 11.11 11 77638 116 34879166
Myasthenic syndrome 29.54 11.11 17 77632 514 34878768
Drug resistance 29.49 11.11 125 77524 25802 34853480
Bone marrow failure 29.46 11.11 136 77513 29117 34850165
Lymphocyte count abnormal 29.27 11.11 23 77626 1175 34878107
Angioedema 29.26 11.11 24 77625 37350 34841932
Actinic keratosis 29.26 11.11 43 77606 4524 34874758
Abdominal abscess 29.22 11.11 41 77608 4134 34875148
C-reactive protein increased 29.15 11.11 213 77436 53885 34825397
Intestinal fibrosis 29.09 11.11 11 77638 122 34879160
Dyskinesia 29.07 11.11 7 77642 22406 34856876
Limb discomfort 28.99 11.11 71 77578 10976 34868306
Cystitis escherichia 28.78 11.11 12 77637 175 34879107
Infection reactivation 28.75 11.11 25 77624 1473 34877809
Fatigue 28.61 11.11 617 77032 370036 34509246
Retinal scar 28.52 11.11 14 77635 304 34878978
Cow pox 28.50 11.11 8 77641 30 34879252
Constipation 28.32 11.11 183 77466 136799 34742483
Cytomegalovirus infection reactivation 28.29 11.11 45 77604 5073 34874209
Pyrexia 28.20 11.11 952 76697 332061 34547221
Product prescribing error 28.13 11.11 8 77641 22919 34856363
Rectal haemorrhage 28.05 11.11 169 77480 40080 34839202
Myopathy 27.95 11.11 72 77577 11482 34867800
Malignant melanoma 27.94 11.11 58 77591 8032 34871250
Rhabdomyolysis 27.45 11.11 70 77579 68093 34811189
Angina pectoris 27.32 11.11 18 77631 31345 34847937
Small intestine adenocarcinoma 27.31 11.11 11 77638 146 34879136
Suicide attempt 27.20 11.11 28 77621 39088 34840194
Intentional product misuse 27.07 11.11 37 77612 45574 34833708
Granulomatosis with polyangiitis 27.02 11.11 22 77627 1183 34878099
Acquired gene mutation 26.79 11.11 23 77626 1332 34877950
Dry mouth 26.71 11.11 17 77632 30148 34849134
Eosinophilic bronchitis 26.69 11.11 12 77637 212 34879070
Gastrointestinal mucosa hyperaemia 26.50 11.11 13 77636 282 34879000
Mucosal inflammation 26.46 11.11 28 77621 38594 34840688
Chest pain 26.38 11.11 169 77480 126593 34752689
Gastrointestinal lymphoma 26.33 11.11 8 77641 42 34879240
Gastrointestinal fistula 26.23 11.11 15 77634 448 34878834
Complications of transplanted kidney 26.13 11.11 41 77608 4568 34874714
Coronary artery disease 25.93 11.11 42 77607 48263 34831019
Hyperkalaemia 25.88 11.11 74 77575 69315 34809967
Listeria sepsis 25.86 11.11 11 77638 169 34879113
Lung neoplasm 25.85 11.11 41 77608 4610 34874672
Stevens-Johnson syndrome 25.84 11.11 5 77644 18634 34860648
Scleroderma 25.76 11.11 24 77625 1548 34877734
Pyoderma gangrenosum 25.70 11.11 23 77626 1408 34877874
Pouchitis 25.42 11.11 17 77632 674 34878608
Epstein-Barr viraemia 25.39 11.11 22 77627 1290 34877992
Papilloma viral infection 25.38 11.11 15 77634 477 34878805
Herpes zoster meningoencephalitis 25.38 11.11 13 77636 310 34878972
Liver disorder 25.24 11.11 142 77507 32855 34846427
Therapy non-responder 25.17 11.11 161 77488 38985 34840297
Legionella infection 25.08 11.11 15 77634 488 34878794
Congenital cytomegalovirus infection 24.99 11.11 7 77642 26 34879256
Lymphocytic infiltration 24.89 11.11 17 77632 698 34878584
Amnesia 24.88 11.11 14 77635 26549 34852733
Liver transplant rejection 24.87 11.11 27 77622 2092 34877190
Uveitis 24.84 11.11 53 77596 7482 34871800
Loss of therapeutic response 24.76 11.11 16 77633 598 34878684
Jejunal stenosis 24.76 11.11 8 77641 53 34879229
Cytomegalovirus chorioretinitis 24.76 11.11 35 77614 3554 34875728
Cardiac disorder 24.59 11.11 36 77613 43090 34836192
Varicella 24.44 11.11 24 77625 1653 34877629
Lung abscess 24.43 11.11 30 77619 2655 34876627
Diffuse large B-cell lymphoma stage IV 24.43 11.11 12 77637 261 34879021
Osteonecrosis of jaw 24.38 11.11 5 77644 17884 34861398
Stiff person syndrome 24.36 11.11 9 77640 93 34879189
Periumbilical abscess 24.26 11.11 8 77641 57 34879225
Intestinal anastomosis complication 24.10 11.11 10 77639 144 34879138
Nephropathy toxic 24.07 11.11 72 77577 12516 34866766
Lactic acidosis 24.06 11.11 25 77624 34747 34844535
Insomnia 24.01 11.11 134 77515 103773 34775509
Intestinal mass 23.94 11.11 15 77634 531 34878751
Tonsil cancer 23.90 11.11 20 77629 1118 34878164
Herpes simplex hepatitis 23.86 11.11 9 77640 99 34879183
Butterfly rash 23.86 11.11 9 77640 99 34879183
Complications of transplanted lung 23.84 11.11 11 77638 207 34879075
Aphthous ulcer 23.69 11.11 41 77608 4954 34874328
Molluscum contagiosum 23.66 11.11 12 77637 280 34879002
Lupus nephritis 23.62 11.11 13 77636 360 34878922
Subdural haematoma 23.49 11.11 8 77641 20413 34858869
Hepatotoxicity 23.22 11.11 102 77547 21383 34857899
Enteritis 23.16 11.11 54 77595 8088 34871194
Rash 23.07 11.11 352 77297 222400 34656882
Graft versus host disease in lung 23.02 11.11 15 77634 569 34878713
Enterovesical fistula 22.96 11.11 17 77632 794 34878488
Mycobacterium chelonae infection 22.89 11.11 17 77632 798 34878484
Gastrointestinal wall thickening 22.88 11.11 22 77627 1476 34877806
Osteoporosis 22.86 11.11 71 77578 12597 34866685
Full blood count decreased 22.78 11.11 6 77643 18082 34861200
Strongyloidiasis 22.61 11.11 29 77620 2682 34876600
Non-Hodgkin's lymphoma 22.55 11.11 22 77627 1503 34877779
Growth retardation 22.49 11.11 24 77625 1824 34877458
Hyperglycaemia 22.46 11.11 33 77616 39447 34839835
Squamous cell carcinoma of the tongue 22.45 11.11 12 77637 313 34878969
Proctitis ulcerative 22.44 11.11 8 77641 74 34879208
Drug interaction 22.40 11.11 360 77289 225586 34653696
Systemic candida 22.32 11.11 34 77615 3692 34875590
Blood creatine phosphokinase increased 22.25 11.11 41 77608 44816 34834466
Arthritis 22.09 11.11 132 77517 31214 34848068
Listeria encephalitis 21.98 11.11 7 77642 44 34879238
Optic neuritis 21.96 11.11 33 77616 3541 34875741
Injection site pain 21.81 11.11 33 77616 38972 34840310
Proctitis 21.70 11.11 27 77622 2422 34876860
Immunosuppressant drug level increased 21.61 11.11 44 77605 6011 34873271
Mental status changes 21.50 11.11 32 77617 38051 34841231
Marrow hyperplasia 21.50 11.11 19 77630 1144 34878138
General physical health deterioration 21.42 11.11 182 77467 128087 34751195
Narcotic bowel syndrome 21.42 11.11 9 77640 134 34879148
Poor venous access 21.34 11.11 40 77609 5143 34874139
Hyperhidrosis 21.31 11.11 91 77558 75601 34803681
Platelet count decreased 21.30 11.11 167 77482 119550 34759732
Cytomegalovirus test positive 21.25 11.11 34 77615 3852 34875430
Ejection fraction decreased 21.19 11.11 8 77641 19146 34860136
Dyspnoea exertional 21.08 11.11 40 77609 43239 34836043
Pneumatosis intestinalis 21.01 11.11 34 77615 3889 34875393
Depression 20.94 11.11 128 77521 96970 34782312
Systemic lupus erythematosus 20.94 11.11 33 77616 3691 34875591
Vomiting 20.90 11.11 406 77243 247215 34632067
Cutaneous leishmaniasis 20.89 11.11 10 77639 205 34879077
Ventricular tachycardia 20.89 11.11 17 77632 26562 34852720
Brain abscess 20.86 11.11 30 77619 3095 34876187
Congenital oesophageal anomaly 20.82 11.11 8 77641 93 34879189
Hepatosplenomegaly 20.80 11.11 35 77614 4134 34875148
Epstein Barr virus positive mucocutaneous ulcer 20.79 11.11 12 77637 365 34878917
Neurological symptom 20.70 11.11 35 77614 4150 34875132
Sleep disorder 20.58 11.11 24 77625 31664 34847618
Cognitive disorder 20.57 11.11 20 77629 28673 34850609
Meningitis cryptococcal 20.50 11.11 26 77623 2378 34876904
Chronic myeloid leukaemia 20.48 11.11 25 77624 2199 34877083
Laryngeal mass 20.33 11.11 6 77643 28 34879254
Arrhythmia 20.30 11.11 30 77619 35778 34843504
Ileocaecal resection 20.21 11.11 7 77642 59 34879223
Gallbladder polyp 20.18 11.11 12 77637 386 34878896
Subcutaneous abscess 20.16 11.11 33 77616 3810 34875472
Terminal ileitis 20.13 11.11 10 77639 223 34879059
Cytomegalovirus duodenitis 20.11 11.11 7 77642 60 34879222
Congenital cystic lung 20.09 11.11 10 77639 224 34879058
Antiphospholipid syndrome 20.07 11.11 13 77636 488 34878794
Disturbance in attention 19.89 11.11 17 77632 25928 34853354
Oesophageal atresia 19.79 11.11 13 77636 500 34878782
Haematuria 19.70 11.11 52 77597 50014 34829268
Odynophagia 19.56 11.11 40 77609 5481 34873801
Peritoneal abscess 19.55 11.11 8 77641 111 34879171
Neoplasm progression 19.46 11.11 14 77635 23286 34855996
Memory impairment 19.42 11.11 42 77607 43276 34836006
Hypersensitivity vasculitis 19.37 11.11 30 77619 3305 34875977
Sebaceous adenoma 19.36 11.11 6 77643 34 34879248
Paracoccidioides infection 19.33 11.11 7 77642 68 34879214
Viral infection 19.30 11.11 84 77565 17539 34861743
Pruritus 19.24 11.11 212 77437 141769 34737513
Autoscopy 19.20 11.11 10 77639 247 34879035
Rash maculo-papular 19.07 11.11 21 77628 28430 34850852
Acne 19.03 11.11 61 77588 11005 34868277
Intestinal ulcer 19.00 11.11 16 77633 902 34878380
Rectal stenosis 18.96 11.11 9 77640 181 34879101
Anaemia 18.95 11.11 385 77264 232950 34646332
Extrapyramidal disorder 18.85 11.11 3 77646 12877 34866405
Pneumonia legionella 18.76 11.11 22 77627 1855 34877427
Neuritis 18.76 11.11 16 77633 918 34878364
Osteonecrosis 18.68 11.11 74 77575 14816 34864466
Urinary tract infection 18.57 11.11 110 77539 83971 34795311
Splenic embolism 18.57 11.11 9 77640 190 34879092
Anal cancer 18.51 11.11 12 77637 451 34878831
Dementia 18.41 11.11 4 77645 13744 34865538
Autoimmune neutropenia 18.36 11.11 10 77639 271 34879011
Mucocutaneous leishmaniasis 18.32 11.11 7 77642 80 34879202
Prostatic specific antigen increased 18.24 11.11 5 77644 14675 34864607
Nausea 18.23 11.11 596 77053 339312 34539970
Herpes simplex test positive 18.11 11.11 9 77640 201 34879081
Toxic epidermal necrolysis 18.09 11.11 13 77636 21633 34857649
Large intestinal ulcer 17.92 11.11 22 77627 1947 34877335
Vision blurred 17.89 11.11 48 77601 45915 34833367
Ventricular fibrillation 17.64 11.11 15 77634 22939 34856343
Urinary incontinence 17.60 11.11 10 77639 18864 34860418
Hypervolaemia 17.59 11.11 11 77638 19698 34859584
Gastrointestinal stoma complication 17.58 11.11 18 77631 1304 34877978
Hypoxia 17.57 11.11 63 77586 55032 34824250
Polyomavirus-associated nephropathy 17.51 11.11 31 77618 3813 34875469
Hodgkin's disease 17.51 11.11 15 77634 866 34878416
Aspiration 17.49 11.11 3 77646 12191 34867091
Chorioretinopathy 17.48 11.11 19 77630 1474 34877808
Ileal ulcer 17.38 11.11 13 77636 617 34878665
Pseudopolyp 17.15 11.11 9 77640 226 34879056
Blood pressure increased 17.14 11.11 283 77366 87819 34791463
Skin lesion 17.12 11.11 95 77554 21866 34857416
Pulmonary nocardiosis 17.12 11.11 15 77634 893 34878389
Pulmonary granuloma 17.10 11.11 19 77630 1511 34877771
Pneumonia cytomegaloviral 17.08 11.11 27 77622 3027 34876255
Cutaneous nocardiosis 16.94 11.11 8 77641 159 34879123
Haematemesis 16.93 11.11 22 77627 27689 34851593
Laser therapy 16.80 11.11 4 77645 6 34879276
Pulmonary oedema 16.77 11.11 52 77597 47477 34831805
Mycobacterium abscessus infection 16.76 11.11 12 77637 532 34878750
Intestinal diaphragm disease 16.66 11.11 9 77640 240 34879042
Oesophagopleural fistula 16.60 11.11 6 77643 58 34879224
Intentional self-injury 16.54 11.11 5 77644 13766 34865516
Prostate cancer 16.52 11.11 40 77609 39609 34839673
Autoimmune haemolytic anaemia 16.43 11.11 33 77616 4463 34874819
Carotid artery perforation 16.42 11.11 4 77645 7 34879275
Relapsing fever 16.37 11.11 8 77641 172 34879110
Sideroblastic anaemia 16.33 11.11 9 77640 250 34879032
Cytomegalovirus syndrome 16.31 11.11 7 77642 110 34879172
Dysarthria 16.20 11.11 33 77616 34749 34844533
Shoulder operation 16.20 11.11 16 77633 1110 34878172
Panniculitis 16.11 11.11 21 77628 1973 34877309
Hepatitis G 16.07 11.11 4 77645 8 34879274
Unevaluable event 15.98 11.11 30 77619 32560 34846722
Episcleritis 15.96 11.11 8 77641 182 34879100
Rectal cancer 15.93 11.11 22 77627 2185 34877097
Short-bowel syndrome 15.88 11.11 9 77640 264 34879018
Neonatal respiratory failure 15.86 11.11 10 77639 358 34878924
Suicidal ideation 15.85 11.11 42 77607 40346 34838936
Cryptococcosis 15.82 11.11 23 77626 2396 34876886
Restlessness 15.81 11.11 20 77629 25462 34853820
Sacroiliitis 15.72 11.11 18 77631 1480 34877802
Localised infection 15.71 11.11 79 77570 17508 34861774
Haemorrhage intracranial 15.52 11.11 8 77641 15938 34863344
Anorectal stenosis 15.46 11.11 4 77645 10 34879272
Testicular cancer metastatic 15.44 11.11 6 77643 72 34879210
Weight fluctuation 15.42 11.11 35 77614 5150 34874132
Cardiogenic shock 15.39 11.11 22 77627 26596 34852686
Psychotic disorder 15.37 11.11 19 77630 24433 34854849
Peripheral T-cell lymphoma unspecified stage IV 15.37 11.11 5 77644 34 34879248
Central nervous system lesion 15.35 11.11 40 77609 6423 34872859
Uveal melanoma 15.34 11.11 3 77646 0 34879282
Aqueductal stenosis 15.34 11.11 3 77646 0 34879282
Aspartate aminotransferase increased 15.33 11.11 88 77561 67695 34811587
Spermatozoa progressive motility decreased 15.30 11.11 7 77642 129 34879153
Diaphragmatic injury 15.30 11.11 7 77642 129 34879153
Skin ulcer 15.30 11.11 93 77556 22123 34857159
Gastric fistula 15.29 11.11 6 77643 74 34879208
Viral test positive 15.28 11.11 8 77641 200 34879082
Skin cancer 15.27 11.11 54 77595 10243 34869039
Drain placement 15.22 11.11 6 77643 75 34879207
Cytomegalovirus oesophagitis 15.22 11.11 11 77638 495 34878787
Antibody test abnormal 14.92 11.11 8 77641 210 34879072
Diabetic ketoacidosis 14.84 11.11 11 77638 18021 34861261
Skin laceration 14.76 11.11 61 77588 12448 34866834
Infectious mononucleosis 14.76 11.11 12 77637 644 34878638
Alanine aminotransferase increased 14.71 11.11 112 77537 80703 34798579
Pneumoperitoneum 14.70 11.11 19 77630 1771 34877511
Cardiac myxoma 14.69 11.11 4 77645 13 34879269
Exposure to SARS-CoV-2 14.69 11.11 11 77638 523 34878759
Disseminated cytomegaloviral infection 14.65 11.11 8 77641 218 34879064
Epstein-Barr virus infection reactivation 14.62 11.11 15 77634 1089 34878193
Lymphocyte count 14.61 11.11 6 77643 84 34879198
Serum sickness 14.53 11.11 20 77629 1980 34877302
Hepatic cytolysis 14.52 11.11 7 77642 14489 34864793
Coloboma 14.52 11.11 7 77642 146 34879136
Drug specific antibody absent 14.48 11.11 6 77643 86 34879196
Herpes simplex colitis 14.46 11.11 4 77645 14 34879268
Meconium peritonitis 14.46 11.11 4 77645 14 34879268
Injection site hypersensitivity 14.46 11.11 9 77640 315 34878967
Hallucination, visual 14.46 11.11 11 77638 17780 34861502
Therapy cessation 14.44 11.11 10 77639 16963 34862319
Adverse drug reaction 14.39 11.11 27 77622 29315 34849967
Dry skin 14.31 11.11 30 77619 31257 34848025
Anorectal disorder 14.31 11.11 15 77634 1117 34878165
Functional gastrointestinal disorder 14.28 11.11 21 77628 2210 34877072
Hemivertebra 14.26 11.11 7 77642 152 34879130
Muscle rigidity 14.21 11.11 3 77646 10515 34868767
Diabetes mellitus 14.20 11.11 163 77486 46710 34832572
Neutropenia 14.15 11.11 254 77395 156524 34722758
Cryptococcal cutaneous infection 14.12 11.11 6 77643 92 34879190
Vitamin B1 decreased 14.11 11.11 9 77640 329 34878953
Tuberculosis gastrointestinal 14.08 11.11 8 77641 236 34879046
Pulmonary paracoccidioidomycosis 14.05 11.11 4 77645 16 34879266
Haemophilus bacteraemia 14.05 11.11 4 77645 16 34879266
Small intestinal ulcer haemorrhage 13.96 11.11 5 77644 47 34879235
Anaplastic large cell lymphoma T- and null-cell types 13.89 11.11 6 77643 96 34879186
Steroid dependence 13.88 11.11 17 77632 1500 34877782
Oropharyngeal pain 13.88 11.11 130 77519 35355 34843927
Glycosylated haemoglobin increased 13.87 11.11 4 77645 11356 34867926
Posterior reversible encephalopathy syndrome 13.74 11.11 51 77598 9903 34869379
Lymph node tuberculosis 13.74 11.11 10 77639 455 34878827
Acute pulmonary histoplasmosis 13.70 11.11 7 77642 166 34879116
American trypanosomiasis 13.69 11.11 8 77641 249 34879033
Respiratory tract infection fungal 13.68 11.11 12 77637 715 34878567
Aplasia pure red cell 13.60 11.11 37 77612 6095 34873187
Contraindicated product administered 13.59 11.11 88 77561 21393 34857889
Campylobacter gastroenteritis 13.57 11.11 13 77636 868 34878414
Fear of injection 13.57 11.11 17 77632 1535 34877747
Listeriosis 13.56 11.11 14 77635 1024 34878258
Rectal discharge 13.55 11.11 8 77641 254 34879028
Red blood cell sedimentation rate increased 13.54 11.11 48 77601 9114 34870168
Gastroenteritis clostridial 13.54 11.11 9 77640 353 34878929
Adenocarcinoma 13.50 11.11 19 77630 1921 34877361
Necrotising herpetic retinopathy 13.49 11.11 4 77645 19 34879263
Thrombotic microangiopathy 13.47 11.11 53 77596 10577 34868705
Gastrointestinal obstruction 13.38 11.11 13 77636 884 34878398
Hiccups 13.37 11.11 3 77646 10079 34869203
Cryptosporidiosis infection 13.34 11.11 10 77639 476 34878806
Inflammation 13.33 11.11 108 77541 28187 34851095
Peritoneal candidiasis 13.33 11.11 4 77645 20 34879262
Blood sodium decreased 13.27 11.11 10 77639 16241 34863041
Hepatobiliary cancer 13.26 11.11 3 77646 3 34879279
Leiomyoma 13.26 11.11 3 77646 3 34879279
Leiomyosarcoma metastatic 13.26 11.11 3 77646 3 34879279
Hepatic angiosarcoma 13.26 11.11 3 77646 3 34879279
Precursor T-lymphoblastic lymphoma/leukaemia stage I 13.26 11.11 3 77646 3 34879279
Enterostomy 13.25 11.11 6 77643 108 34879174
Hepatitis B 13.17 11.11 36 77613 5947 34873335
Olfactory nerve disorder 13.16 11.11 4 77645 21 34879261
Altered state of consciousness 13.15 11.11 19 77630 22874 34856408
Hallucination, auditory 13.14 11.11 5 77644 11912 34867370
Respiratory symptom 13.10 11.11 18 77631 1779 34877503
Accidental exposure to product 13.10 11.11 6 77643 12796 34866486
Chromaturia 13.10 11.11 8 77641 14512 34864770
Anger 13.08 11.11 5 77644 11879 34867403
Inappropriate antidiuretic hormone secretion 13.02 11.11 6 77643 12747 34866535
Erectile dysfunction 13.01 11.11 16 77633 20621 34858661
Rheumatoid arthritis 12.98 11.11 136 77513 38102 34841180
Gastrointestinal oedema 12.88 11.11 16 77633 1433 34877849
Diffuse large B-cell lymphoma stage III 12.87 11.11 5 77644 60 34879222
Small intestinal resection 12.84 11.11 10 77639 504 34878778
Ulcer 12.81 11.11 46 77603 8789 34870493
Incorrect dose administered 12.78 11.11 142 77507 40373 34838909
Stenosis 12.67 11.11 16 77633 1457 34877825
Angina unstable 12.67 11.11 5 77644 11648 34867634
Pulmonary fibrosis 12.66 11.11 77 77572 18319 34860963
Overgrowth bacterial 12.63 11.11 6 77643 121 34879161
Oropharyngeal squamous cell carcinoma 12.58 11.11 7 77642 198 34879084
Fluctuance 12.58 11.11 4 77645 25 34879257
Migraine 12.56 11.11 74 77575 17404 34861878
Mycoplasma test positive 12.54 11.11 6 77643 123 34879159
Epstein-Barr virus antibody positive 12.53 11.11 8 77641 293 34878989
Pancreatitis acute 12.50 11.11 106 77543 28035 34851247
Polyarteritis nodosa 12.45 11.11 8 77641 296 34878986
Intestinal adenocarcinoma 12.37 11.11 5 77644 67 34879215
C-reactive protein abnormal 12.34 11.11 45 77604 8665 34870617
Skin papilloma 12.33 11.11 19 77630 2084 34877198
Thrombocytopenia 12.31 11.11 259 77390 155988 34723294
Polydipsia 12.29 11.11 27 77622 3888 34875394
Pharyngeal paraesthesia 12.28 11.11 11 77638 674 34878608
Acute respiratory failure 12.26 11.11 32 77617 30896 34848386
Eosinophilic myocarditis 12.21 11.11 10 77639 542 34878740
Nail pitting 12.19 11.11 8 77641 307 34878975
Atrial flutter 12.19 11.11 10 77639 15564 34863718
Tremor 12.12 11.11 121 77528 82466 34796816
Fluid retention 12.11 11.11 26 77623 26861 34852421
Myoclonus 12.10 11.11 9 77640 14716 34864566
Haemoglobin decreased 12.08 11.11 192 77457 120580 34758702
Rectal tenesmus 12.06 11.11 12 77637 840 34878442
Anaplastic large cell lymphoma T- and null-cell types stage III 12.05 11.11 3 77646 6 34879276
Actinic cheilitis 12.05 11.11 3 77646 6 34879276
Dysphagia 12.05 11.11 85 77564 62296 34816986
Pneumonitis 11.99 11.11 37 77612 33841 34845441
Atelectasis 11.97 11.11 13 77636 17714 34861568
Skin exfoliation 11.97 11.11 27 77622 27405 34851877
Colonoscopy abnormal 11.92 11.11 5 77644 74 34879208
Pain 11.88 11.11 355 77294 204320 34674962
Underdose 11.88 11.11 8 77641 13772 34865510
Disseminated cryptococcosis 11.83 11.11 15 77634 1371 34877911
Cheilitis 11.83 11.11 20 77629 2371 34876911
Paranoia 11.83 11.11 6 77643 12062 34867220
Small intestine ulcer 11.80 11.11 9 77640 440 34878842
Mycobacterium kansasii infection 11.79 11.11 8 77641 325 34878957
Lip swelling 11.77 11.11 11 77638 16069 34863213
Mucous stools 11.76 11.11 17 77632 1761 34877521
Gastrointestinal cancer metastatic 11.74 11.11 5 77644 77 34879205
Placental disorder 11.74 11.11 5 77644 77 34879205
B-cell lymphoma stage IV 11.74 11.11 5 77644 77 34879205
Acute haemorrhagic ulcerative colitis 11.74 11.11 3 77646 7 34879275
Fungal skin infection 11.69 11.11 21 77628 2613 34876669
Gynaecomastia 11.69 11.11 4 77645 10176 34869106
Oedema 11.67 11.11 57 77592 45684 34833598
Ischaemic stroke 11.66 11.11 14 77635 18236 34861046
Electrolyte imbalance 11.60 11.11 9 77640 14403 34864879
Atypical mycobacterial infection 11.58 11.11 12 77637 881 34878401
Drug specific antibody 11.57 11.11 8 77641 335 34878947
Cutaneous T-cell lymphoma stage III 11.52 11.11 4 77645 34 34879248
Faecal calprotectin abnormal 11.50 11.11 7 77642 235 34879047
Acute coronary syndrome 11.49 11.11 8 77641 13537 34865745
Gastrointestinal stoma output decreased 11.40 11.11 5 77644 83 34879199
Mucormycosis 11.37 11.11 34 77615 5908 34873374
Leiomyosarcoma 11.31 11.11 6 77643 154 34879128
Mood altered 11.21 11.11 3 77646 8949 34870333
Primary mediastinal large B-cell lymphoma stage IV 11.20 11.11 3 77646 9 34879273
Proctalgia 11.20 11.11 33 77616 5690 34873592
Death neonatal 11.18 11.11 8 77641 354 34878928
Blood potassium decreased 11.17 11.11 14 77635 17901 34861381
Brachycephaly 11.14 11.11 5 77644 88 34879194
Depressed mood 11.13 11.11 16 77633 19301 34859981

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Off label use 1272.61 9.74 4896 186193 902319 78650980
Drug ineffective 817.83 9.74 4884 186205 1076029 78477270
Colitis ulcerative 637.56 9.74 584 190505 34158 79519141
Condition aggravated 545.90 9.74 2510 188579 498614 79054685
Treatment failure 532.70 9.74 1227 189862 169259 79384040
Completed suicide 527.22 9.74 13 191076 245754 79307545
Intentional product use issue 502.13 9.74 1119 189970 150993 79402306
Death 482.30 9.74 391 190698 566123 78987176
Post transplant lymphoproliferative disorder 383.83 9.74 274 190815 11190 79542109
Exposure during pregnancy 379.58 9.74 784 190305 100348 79452951
Cytomegalovirus infection 371.33 9.74 484 190605 42160 79511139
Inappropriate schedule of product administration 357.41 9.74 906 190183 132722 79420577
Fall 352.13 9.74 390 190699 487239 79066060
Drug level below therapeutic 332.83 9.74 236 190853 9534 79543765
Drug abuse 323.13 9.74 16 191073 162675 79390624
Epstein-Barr virus infection 319.86 9.74 270 190819 14146 79539153
Intestinal stenosis 318.27 9.74 163 190926 3591 79549708
Toxicity to various agents 309.92 9.74 332 190757 421208 79132091
Hepatosplenic T-cell lymphoma 280.56 9.74 98 190991 780 79552519
Drug intolerance 272.72 9.74 1304 189785 262815 79290484
Product use issue 270.43 9.74 1107 189982 208715 79344584
Fistula 270.05 9.74 234 190855 12706 79540593
Hypotension 257.71 9.74 411 190678 439906 79113393
Product use in unapproved indication 256.95 9.74 1234 189855 249125 79304174
Premature delivery 248.68 9.74 294 190795 23173 79530126
Diffuse large B-cell lymphoma 248.10 9.74 217 190872 11932 79541367
Cushingoid 245.72 9.74 195 190894 9357 79543942
Faecal calprotectin increased 244.15 9.74 157 190932 5384 79547915
Disease recurrence 243.63 9.74 404 190685 43705 79509594
Anal fistula 234.84 9.74 167 190922 6777 79546522
Bone erosion 234.31 9.74 250 190839 17597 79535702
Maternal exposure during pregnancy 234.14 9.74 790 190299 135748 79417551
Febrile neutropenia 231.35 9.74 133 190956 230866 79322433
Frequent bowel movements 230.72 9.74 318 190771 29221 79524078
Nodular regenerative hyperplasia 228.60 9.74 95 190994 1266 79552033
Lupus-like syndrome 225.53 9.74 218 190871 13639 79539660
Therapeutic product effect incomplete 217.34 9.74 790 190299 140855 79412444
Malignant neoplasm progression 213 9.74 35 191054 135955 79417344
Drug eruption 211.94 9.74 379 190710 43556 79509743
Anal abscess 211.22 9.74 177 190912 9178 79544121
Therapeutic product effect decreased 209.83 9.74 863 190226 163000 79390299
Hyponatraemia 204.44 9.74 85 191004 177763 79375536
Lymphoproliferative disorder 199.08 9.74 139 190950 5476 79547823
Atrial fibrillation 196.61 9.74 115 190974 197771 79355528
Therapeutic response decreased 192.03 9.74 466 190623 66387 79486912
Transplant rejection 188.79 9.74 233 190856 19204 79534095
Ileal stenosis 188.58 9.74 99 190990 2299 79551000
Somnolence 188.25 9.74 177 190912 238804 79314495
Confusional state 187.63 9.74 295 190794 317702 79235597
Red blood cell sedimentation rate increased 183.95 9.74 366 190723 45576 79507723
Basal cell carcinoma 182.31 9.74 324 190765 37051 79516248
Drug level decreased 180.74 9.74 197 190892 14205 79539094
Abscess 174.62 9.74 244 190845 22707 79530592
SLE arthritis 173.53 9.74 62 191027 531 79552768
Disseminated tuberculosis 170.79 9.74 113 190976 4070 79549229
Haemophagocytic lymphohistiocytosis 170.40 9.74 235 190854 21602 79531697
C-reactive protein increased 169.46 9.74 685 190404 128342 79424957
Blood pressure fluctuation 161.73 9.74 438 190651 66707 79486592
Epstein-Barr virus associated lymphoproliferative disorder 160.38 9.74 102 190987 3430 79549869
Dyspnoea 157.51 9.74 1307 189782 855718 78697581
Cardiac failure congestive 157.40 9.74 72 191017 142330 79410969
Arthritis 157.36 9.74 618 190471 114262 79439037
Pneumocystis jirovecii pneumonia 156.23 9.74 280 190809 32228 79521071
Anal fissure 156.11 9.74 137 190952 7566 79545733
Intentional overdose 155.76 9.74 32 191057 105928 79447371
Acute kidney injury 154.41 9.74 680 190409 518724 79034575
Kidney transplant rejection 151.53 9.74 153 190936 10093 79543206
Haematochezia 150.96 9.74 508 190581 87137 79466162
Intestinal resection 149.79 9.74 100 190989 3657 79549642
Intestinal obstruction 145.69 9.74 320 190769 42700 79510599
Cytomegalovirus colitis 145.49 9.74 107 190982 4578 79548721
Hypokalaemia 145.48 9.74 82 191007 143958 79409341
Squamous cell carcinoma 144.89 9.74 183 190906 15439 79537860
Cytomegalovirus viraemia 143.13 9.74 165 190924 12656 79540643
Cardio-respiratory arrest 141.57 9.74 42 191047 108468 79444831
Bradycardia 141.53 9.74 74 191015 135483 79417816
Syncope 140.00 9.74 134 190955 179315 79373984
Overdose 138.59 9.74 142 190947 184064 79369235
Inflammation 135.46 9.74 513 190576 93240 79460059
Progressive multifocal leukoencephalopathy 133.47 9.74 203 190886 20397 79532902
Electrocardiogram QT prolonged 131.40 9.74 28 191061 90358 79462941
Therapeutic response shortened 128.74 9.74 174 190915 15689 79537610
Large intestinal stenosis 128.50 9.74 82 191007 2774 79550525
Acute febrile neutrophilic dermatosis 128.35 9.74 92 190997 3780 79549519
Vasculitis 128.11 9.74 222 190867 24880 79528419
Dizziness 128.03 9.74 739 190350 525702 79027597
Arthralgia 126.87 9.74 1998 189091 569805 78983494
Cardiac arrest 124.62 9.74 137 190952 171959 79381340
Rheumatoid arthritis 123.94 9.74 890 190199 207580 79345719
Cholestasis of pregnancy 123.26 9.74 56 191033 937 79552362
Demyelination 122.68 9.74 122 190967 7901 79545398
Drug specific antibody present 122.33 9.74 112 190977 6540 79546759
Neutrophil count decreased 121.43 9.74 37 191052 93922 79459377
Erythema nodosum 120.86 9.74 101 190988 5216 79548083
Colectomy 120.73 9.74 84 191005 3290 79550009
Loss of consciousness 118.00 9.74 137 190952 167806 79385493
Rheumatoid nodule 117.47 9.74 175 190914 17263 79536036
Scleritis 116.51 9.74 91 190998 4265 79549034
Hypoglycaemia 116.00 9.74 49 191040 101545 79451754
Abdominal pain 115.74 9.74 1434 189655 388135 79165164
Drug tolerance decreased 115.59 9.74 149 190940 12829 79540470
Pancytopenia 114.25 9.74 734 190355 165011 79388288
Retinitis 113.63 9.74 100 190989 5543 79547756
Elbow deformity 113.56 9.74 61 191028 1486 79551813
Clostridium difficile infection 113.55 9.74 289 190800 42396 79510903
Product dose omission issue 112.52 9.74 268 190821 247269 79306030
Blood iron abnormal 111.97 9.74 58 191031 1309 79551990
Clear cell renal cell carcinoma 111.05 9.74 72 191017 2504 79550795
Osteoporosis 110.85 9.74 333 190756 53779 79499520
Leukopenia 110.57 9.74 562 190527 115951 79437348
B-cell lymphoma 109.17 9.74 102 190987 6113 79547186
Lung transplant rejection 108.56 9.74 59 191030 1472 79551827
Pulmonary tuberculosis 108.26 9.74 113 190976 7752 79545547
Coma 107.97 9.74 53 191036 100596 79452703
Nocardiosis 107.14 9.74 97 190992 5582 79547717
Sedation 106.65 9.74 4 191085 51891 79501408
Myocardial infarction 106.44 9.74 173 190916 183956 79369343
Joint dislocation 105.63 9.74 164 190925 16775 79536524
Dehydration 105.57 9.74 278 190811 247909 79305390
Cerebrovascular accident 105.56 9.74 130 190959 155162 79398137
Coombs positive haemolytic anaemia 104.38 9.74 52 191037 1078 79552221
Premature labour 103.95 9.74 114 190975 8276 79545023
Lupus nephritis 103.23 9.74 73 191016 2935 79550364
Diarrhoea haemorrhagic 102.62 9.74 142 190947 13092 79540207
Asthenia 101.76 9.74 763 190326 510926 79042373
Aphthous ulcer 100.44 9.74 160 190929 16729 79536570
Tuberculosis 100.21 9.74 151 190938 15047 79538252
Depressed level of consciousness 99.06 9.74 54 191035 96598 79456701
Weight decreased 98.89 9.74 1292 189797 353906 79199393
Drug level above therapeutic 98.61 9.74 113 190976 8610 79544689
Pre-eclampsia 98.42 9.74 102 190987 6939 79546360
Ulcer 98.16 9.74 220 190869 29752 79523547
Histoplasmosis disseminated 97.12 9.74 64 191025 2289 79551010
Panniculitis 94.82 9.74 132 190957 12239 79541060
Normal newborn 94.48 9.74 100 190989 6972 79546327
Constipation 94.36 9.74 354 190735 282696 79270603
Platelet count decreased 93.93 9.74 204 190885 194460 79358839
Intestinal fistula 92.58 9.74 52 191037 1386 79551913
Antinuclear antibody positive 92.23 9.74 104 190985 7786 79545513
Proteinuria 90.58 9.74 224 190865 32278 79521021
Fatigue 90.13 9.74 1628 189461 928099 78625200
Contusion 89.57 9.74 136 190953 148640 79404659
Blood glucose increased 89.48 9.74 86 191003 114889 79438410
Hepatic cirrhosis 89.40 9.74 233 190856 34673 79518626
Plasmablastic lymphoma 89.24 9.74 37 191052 490 79552809
Epstein-Barr virus test positive 86.67 9.74 46 191043 1093 79552206
Exostosis 85.90 9.74 149 190940 16709 79536590
Kaposi's sarcoma 85.45 9.74 40 191049 719 79552580
Seizure 84.55 9.74 206 190883 188628 79364671
Orthostatic hypotension 84.55 9.74 16 191073 56148 79497151
Respiratory arrest 83.29 9.74 18 191071 57532 79495767
Chronic obstructive pulmonary disease 82.88 9.74 51 191038 85368 79467931
Hyperkalaemia 82.87 9.74 91 190998 114307 79438992
JC virus infection 82.63 9.74 71 191018 3810 79549489
Mycobacterial infection 81.98 9.74 69 191020 3599 79549700
Aspergillus infection 81.97 9.74 157 190932 19004 79534295
Balance disorder 79.21 9.74 72 191017 98785 79454514
Cardiac failure 79.13 9.74 157 190932 154685 79398614
Abortion spontaneous 78.71 9.74 200 190889 29307 79523992
Agitation 78.28 9.74 74 191015 99641 79453658
Tremor 78.17 9.74 183 190906 169900 79383399
Synovial fluid analysis 78.08 9.74 56 191033 2303 79550996
Histoplasmosis 77.95 9.74 56 191033 2309 79550990
Metabolic acidosis 77.70 9.74 51 191038 82478 79470821
Wrong technique in product usage process 77.58 9.74 40 191049 73835 79479464
Tenosynovitis stenosans 77.38 9.74 62 191027 3016 79550283
Lactic acidosis 77.06 9.74 36 191053 70323 79482976
Chronic allograft nephropathy 76.67 9.74 49 191040 1662 79551637
Intentional product misuse 76.62 9.74 69 191020 95096 79458203
Squamous cell carcinoma of skin 75.42 9.74 127 190962 13906 79539393
Colitis 74.79 9.74 361 190728 72946 79480353
Granulomatosis with polyangiitis 74.69 9.74 59 191030 2811 79550488
Immunosuppression 74.37 9.74 120 190969 12683 79540616
Serotonin syndrome 74.14 9.74 10 191079 45017 79508282
Ileostomy 73.97 9.74 48 191041 1672 79551627
Skin ulcer 73.85 9.74 291 190798 53859 79499440
Neuropathy peripheral 73.31 9.74 142 190947 141163 79412136
Impaired gastric emptying 72.76 9.74 106 190983 10247 79543052
Renal cell carcinoma 72.32 9.74 84 191005 6494 79546805
Decreased appetite 72.14 9.74 502 190587 341916 79211383
Granuloma skin 71.98 9.74 99 190990 9075 79544224
Defaecation urgency 71.92 9.74 79 191010 5745 79547554
Gastrointestinal haemorrhage 71.91 9.74 154 190935 147565 79405734
Musculoskeletal stiffness 71.65 9.74 687 190402 174321 79378978
Joint stiffness 71.46 9.74 238 190851 40592 79512707
Pulmonary fibrosis 70.96 9.74 250 190839 43862 79509437
Pyoderma gangrenosum 70.66 9.74 67 191022 4091 79549208
Acute myocardial infarction 70.66 9.74 49 191040 76987 79476312
Suicide attempt 70.59 9.74 57 191032 82875 79470424
Hallucination 70.44 9.74 61 191028 85684 79467615
Inflammatory bowel disease 70.38 9.74 77 191012 5574 79547725
Gastrointestinal lymphoma 70.31 9.74 23 191066 146 79553153
T-cell lymphoma 70.29 9.74 42 191047 1261 79552038
Synovitis 69.97 9.74 608 190481 150126 79403173
Hair follicle tumour benign 69.60 9.74 30 191059 440 79552859
Hepatic function abnormal 69.59 9.74 353 190736 72754 79480545
Gastrointestinal inflammation 69.37 9.74 88 191001 7456 79545843
Epstein-Barr virus associated lymphoma 69.08 9.74 39 191050 1050 79552249
Epidermodysplasia verruciformis 68.84 9.74 28 191061 352 79552947
Hyperhidrosis 68.81 9.74 164 190925 151328 79401971
Drug ineffective for unapproved indication 68.79 9.74 274 190815 50964 79502335
Pneumonia aspiration 67.77 9.74 38 191051 66929 79486370
Blood parathyroid hormone decreased 67.08 9.74 103 190986 10433 79542866
Drug hypersensitivity 67.02 9.74 1047 190042 297869 79255430
Unresponsive to stimuli 66.80 9.74 25 191064 55763 79497536
Urinary retention 66.77 9.74 26 191063 56604 79496695
Live birth 66.39 9.74 142 190947 18602 79534697
Hypersensitivity 65.59 9.74 936 190153 261303 79291996
Dyskinesia 64.80 9.74 14 191075 44759 79508540
Heart transplant rejection 64.59 9.74 42 191047 1468 79551831
Therapeutic reaction time decreased 64.48 9.74 59 191030 3442 79549857
Angiocentric lymphoma 64.37 9.74 35 191054 874 79552425
International normalised ratio increased 64.04 9.74 65 191024 84656 79468643
Foot deformity 64.03 9.74 163 190926 23911 79529388
Extrapulmonary tuberculosis 63.77 9.74 27 191062 378 79552921
Palmar-plantar erythrodysaesthesia syndrome 63.46 9.74 4 191085 33130 79520169
Anaemia 63.11 9.74 722 190367 444293 79109006
Myasthenia gravis crisis 63.04 9.74 37 191052 1074 79552225
Rebound effect 62.85 9.74 82 191007 7144 79546155
Human herpesvirus 8 infection 62.39 9.74 38 191051 1182 79552117
Accidental overdose 62.37 9.74 10 191079 39571 79513728
Infusion related reaction 62.12 9.74 833 190256 229404 79323895
Contraindicated product administered 61.82 9.74 613 190476 156925 79396374
Uveitis 61.34 9.74 129 190960 16701 79536598
Fistula discharge 60.86 9.74 39 191050 1329 79551970
Gestational hypertension 60.81 9.74 44 191045 1835 79551464
Immunosuppressant drug level increased 59.95 9.74 90 190999 8937 79544362
Cholangitis sclerosing 59.75 9.74 50 191039 2587 79550712
Intentional self-injury 58.98 9.74 5 191084 32414 79520885
Depression 58.83 9.74 293 190796 216497 79336802
Small intestinal stenosis 58.71 9.74 32 191057 803 79552496
Insomnia 58.47 9.74 346 190743 244824 79308475
Suicidal ideation 58.35 9.74 58 191031 76282 79477017
Injection site erythema 57.96 9.74 61 191028 78136 79475163
Lymphopenia 57.88 9.74 183 190906 30374 79522925
Lupus vasculitis 57.75 9.74 28 191061 546 79552753
Delirium 57.32 9.74 71 191018 84556 79468743
Heart rate irregular 56.75 9.74 190 190899 32489 79520810
Vomiting 56.69 9.74 1191 189898 664637 78888662
C-reactive protein abnormal 56.60 9.74 248 190841 48119 79505180
Oedema peripheral 56.54 9.74 363 190726 251925 79301374
Anxiety 56.50 9.74 356 190733 248156 79305143
Rheumatoid factor negative 56.08 9.74 35 191054 1138 79552161
Pleuritic pain 56.05 9.74 93 190996 10059 79543240
Listeriosis 55.88 9.74 45 191044 2205 79551094
Back pain 55.52 9.74 464 190625 303716 79249583
Central nervous system lymphoma 55.20 9.74 45 191044 2244 79551055
Pain 55.04 9.74 1276 189813 702526 78850773
Crohn's disease 55.02 9.74 43 191046 2017 79551282
Injection site swelling 54.97 9.74 22 191067 47110 79506189
Cognitive disorder 54.75 9.74 52 191037 69874 79483425
Papilloma viral infection 54.74 9.74 40 191049 1694 79551605
Bone marrow failure 54.54 9.74 255 190834 50852 79502447
Varicella zoster virus infection 54.42 9.74 60 191029 4381 79548918
Episcleritis 54.31 9.74 33 191056 1022 79552277
Hypocalcaemia 53.97 9.74 26 191063 49898 79503401
Cytomegalovirus enteritis 53.95 9.74 30 191059 784 79552515
Immunosuppressant drug level decreased 53.89 9.74 42 191047 1962 79551337
Medication error 53.80 9.74 51 191038 68591 79484708
Disorientation 53.61 9.74 43 191046 62733 79490566
Injection site pain 53.23 9.74 148 190941 129690 79423609
Aggression 52.90 9.74 28 191061 50930 79502369
Sopor 52.78 9.74 8 191081 33002 79520297
Plasma cell myeloma 52.78 9.74 31 191058 53228 79500071
Mucosal inflammation 52.69 9.74 62 191027 75518 79477781
Joint swelling 52.66 9.74 978 190111 287668 79265631
Diabetes mellitus 52.65 9.74 345 190744 78045 79475254
Osteonecrosis 52.42 9.74 179 190910 30916 79522383
Skin necrosis 51.82 9.74 126 190963 17961 79535338
Hypogammaglobulinaemia 51.61 9.74 103 190986 12848 79540451
Abnormal behaviour 51.48 9.74 12 191077 36409 79516890
Neoplasm progression 51.33 9.74 30 191059 51652 79501647
Body temperature fluctuation 51.15 9.74 54 191035 3753 79549546
Lymphadenitis 50.44 9.74 59 191030 4596 79548703
White blood cell count decreased 50.21 9.74 256 190833 188032 79365267
Nausea 50.05 9.74 1834 189255 955362 78597937
Anal stenosis 49.74 9.74 24 191065 463 79552836
Transplant dysfunction 49.40 9.74 73 191016 7148 79546151
Food intolerance 48.91 9.74 53 191036 3795 79549504
Mental status changes 48.77 9.74 53 191036 66906 79486393
Hyperglycaemia 48.70 9.74 58 191031 70277 79483022
Abdominal abscess 48.68 9.74 72 191017 7055 79546244
Laryngitis 48.40 9.74 114 190975 15925 79537374
Poor venous access 48.38 9.74 123 190966 18026 79535273
Enterocutaneous fistula 48.23 9.74 39 191050 1922 79551377
Brain abscess 47.65 9.74 59 191030 4877 79548422
Restlessness 47.59 9.74 26 191063 46466 79506833
Liver transplant rejection 47.11 9.74 48 191041 3200 79550099
Red blood cell sedimentation rate abnormal 46.75 9.74 133 190956 20830 79532469
Non-cirrhotic portal hypertension 46.73 9.74 23 191066 464 79552835
Dysgeusia 46.57 9.74 41 191048 57136 79496163
Transient ischaemic attack 46.39 9.74 35 191054 52660 79500639
Abscess intestinal 46.12 9.74 44 191045 2707 79550592
Autoimmune hepatitis 46.11 9.74 93 190996 11690 79541609
Eosinophilic granulomatosis with polyangiitis 45.81 9.74 50 191039 3610 79549689
Granuloma 45.80 9.74 76 191013 8221 79545078
Poisoning 45.70 9.74 4 191085 25268 79528031
Actinic keratosis 45.60 9.74 64 191025 5978 79547321
Neutropenia 45.49 9.74 455 190634 287255 79266044
Vision blurred 45.46 9.74 118 190971 105780 79447519
Bone pain 45.37 9.74 40 191049 55702 79497597
Tenosynovitis 45.26 9.74 109 190980 15445 79537854
Mycobacterium abscessus infection 45.08 9.74 31 191058 1191 79552108
Portal hypertension 44.57 9.74 69 191020 7039 79546260
Device expulsion 44.39 9.74 5 191084 25856 79527443
Disseminated cytomegaloviral infection 44.29 9.74 22 191067 453 79552846
Pneumonia cytomegaloviral 44.17 9.74 57 191032 4912 79548387
Full blood count decreased 44.05 9.74 6 191083 26813 79526486
Hepatosplenomegaly 43.91 9.74 63 191026 6006 79547293
Ear infection 43.73 9.74 181 190908 34251 79519048
Ventricular tachycardia 43.59 9.74 23 191066 41912 79511387
Strongyloidiasis 43.23 9.74 50 191039 3848 79549451
Rectal abscess 43.16 9.74 38 191051 2107 79551192
Premature rupture of membranes 43.14 9.74 51 191038 4018 79549281
Proctocolectomy 42.96 9.74 16 191073 156 79553143
Pulmonary oedema 42.94 9.74 92 190997 88162 79465137
Thrombocytopenia 42.56 9.74 418 190671 264841 79288458
Coronary artery disease 42.21 9.74 57 191032 65417 79487882
Peliosis hepatis 42.03 9.74 15 191074 128 79553171
Intestinal anastomosis 42.02 9.74 24 191065 661 79552638
Pancreatitis 41.98 9.74 295 190794 68280 79485019
Varicella 41.93 9.74 43 191046 2889 79550410
Chorioretinopathy 41.88 9.74 38 191051 2193 79551106
Gastrointestinal wall thickening 41.73 9.74 41 191048 2616 79550683
Anti-neutrophil cytoplasmic antibody positive vasculitis 41.64 9.74 48 191041 3681 79549618
Abdominal adhesions 41.60 9.74 47 191042 3526 79549773
Ankylosing spondylitis 41.55 9.74 91 190998 12114 79541185
Subcutaneous abscess 41.47 9.74 71 191018 7878 79545421
Herpes simplex hepatitis 41.44 9.74 22 191067 523 79552776
Rheumatoid lung 41.40 9.74 51 191038 4194 79549105
Pneumatosis intestinalis 41.38 9.74 63 191026 6334 79546965
Impaired work ability 41.13 9.74 122 190967 19559 79533740
Mucous stools 40.94 9.74 56 191033 5106 79548193
Paraesthesia 40.88 9.74 251 190838 176072 79377227
Cardiac disorder 40.64 9.74 59 191030 65698 79487601
Herpes zoster 40.37 9.74 370 190719 92713 79460586
Cytokine release syndrome 40.07 9.74 18 191071 35980 79517319
Pulmonary embolism 39.98 9.74 244 190845 171410 79381889
Aplasia pure red cell 39.75 9.74 69 191020 7741 79545558
Pulmonary vasculitis 39.68 9.74 24 191065 737 79552562
Multiple sclerosis relapse 39.58 9.74 32 191057 46501 79506798
Lung abscess 39.45 9.74 49 191040 4063 79549236
Small intestinal obstruction 39.17 9.74 149 190940 27123 79526176
Lymphoma 39.16 9.74 111 190978 17349 79535950
Meningitis listeria 39.15 9.74 27 191062 1042 79552257
Injection site bruising 39.05 9.74 25 191064 40977 79512322
Fluid retention 39.00 9.74 67 191022 69742 79483557
Hypomagnesaemia 38.98 9.74 33 191056 46878 79506421
Fungal endocarditis 38.98 9.74 22 191067 592 79552707
Osteonecrosis of jaw 38.97 9.74 28 191061 43198 79510101
Pulmonary nocardiosis 38.60 9.74 29 191060 1282 79552017
Neuroendocrine carcinoma of the skin 38.58 9.74 29 191060 1283 79552016
Blood calcium decreased 38.53 9.74 14 191075 31805 79521494
Disturbance in attention 38.36 9.74 39 191050 50762 79502537
Drug tolerance 38.24 9.74 72 191017 8603 79544696
Hypervolaemia 38.03 9.74 28 191061 42662 79510637
Device dislocation 37.83 9.74 8 191081 25962 79527337
Accidental exposure to product 37.56 9.74 14 191075 31308 79521991
Complications of transplanted kidney 37.43 9.74 60 191029 6306 79546993
Obliterative bronchiolitis 37.26 9.74 41 191048 2987 79550312
Product label confusion 37.19 9.74 31 191058 1595 79551704
Therapy non-responder 37.08 9.74 361 190728 91944 79461355
Hepatic enzyme increased 36.92 9.74 629 190460 181981 79371318
Cytomegalovirus chorioretinitis 36.84 9.74 55 191034 5435 79547864
Dysarthria 36.78 9.74 66 191023 67556 79485743
Mycobacterium avium complex infection 36.63 9.74 50 191039 4550 79548749
Inappropriate antidiuretic hormone secretion 36.54 9.74 9 191080 26304 79526995
Phaeohyphomycosis 36.41 9.74 27 191062 1170 79552129
Intestinal perforation 36.40 9.74 108 190981 17318 79535981
Melaena 36.30 9.74 56 191033 60834 79492465
Candida infection 35.99 9.74 184 190905 38030 79515269
Polyomavirus viraemia 35.88 9.74 31 191058 1676 79551623
Cutaneous T-cell lymphoma 35.71 9.74 38 191051 2665 79550634
Visceral leishmaniasis 35.67 9.74 26 191063 1097 79552202
Skin lesion 35.66 9.74 196 190893 41648 79511651
Crepitations 35.60 9.74 76 191013 9941 79543358
Angina pectoris 35.45 9.74 43 191046 51689 79501610
Hepatitis 35.45 9.74 242 190847 55485 79497814
Diabetic ketoacidosis 35.05 9.74 19 191070 34103 79519196
Rhabdomyolysis 34.96 9.74 128 190961 103003 79450296
Epicondylitis 34.94 9.74 34 191055 2144 79551155
Muscle injury 34.75 9.74 39 191050 48522 79504777
Caesarean section 34.51 9.74 86 191003 12449 79540850
Memory impairment 34.47 9.74 144 190945 111590 79441709
Ejection fraction decreased 34.44 9.74 20 191069 34557 79518742
Injection site inflammation 34.39 9.74 45 191044 3931 79549368
Sinus bradycardia 34.36 9.74 9 191080 25238 79528061
Myopathy 34.33 9.74 118 190971 20445 79532854
Renal mass 33.99 9.74 41 191048 3299 79550000
Liver function test increased 33.70 9.74 186 190903 39587 79513712
Allergy to chemicals 33.36 9.74 36 191053 2566 79550733
Legionella infection 33.36 9.74 22 191067 788 79552511
Overlap syndrome 33.19 9.74 24 191065 1000 79552299
Haematoma 33.08 9.74 46 191043 52149 79501150
Infectious mononucleosis 32.99 9.74 32 191057 2010 79551289
Emotional distress 32.14 9.74 29 191060 39940 79513359
Wrist deformity 32.01 9.74 32 191057 2085 79551214
Rectal fissure 31.94 9.74 23 191066 952 79552347
Pneumocystis jirovecii infection 31.89 9.74 37 191052 2857 79550442
Loss of therapeutic response 31.61 9.74 22 191067 862 79552437
Subdural haematoma 31.57 9.74 18 191071 31416 79521883
Anaplastic large-cell lymphoma 31.49 9.74 14 191075 222 79553077
Malignant melanoma 31.40 9.74 92 190997 14649 79538650
Muscle rigidity 31.38 9.74 5 191084 19877 79533422
Thiopurine methyltransferase decreased 31.34 9.74 16 191073 350 79552949
Antiphospholipid syndrome 31.24 9.74 30 191059 1861 79551438
Anal cancer 31.02 9.74 21 191068 786 79552513
Rectal discharge 31.00 9.74 21 191068 787 79552512
Anaphylactic reaction 30.98 9.74 322 190767 83421 79469878
Jejunal stenosis 30.91 9.74 11 191078 93 79553206
Meningitis cryptococcal 30.82 9.74 40 191049 3466 79549833
Natural killer-cell leukaemia 30.81 9.74 11 191078 94 79553205
Cardiogenic shock 30.72 9.74 33 191056 41881 79511418
Lupus vulgaris 30.71 9.74 39 191050 3307 79549992
Tachycardia 30.69 9.74 275 190814 177493 79375806
Rhegmatogenous retinal detachment 30.64 9.74 13 191076 183 79553116
Irritability 30.60 9.74 32 191057 41112 79512187
Cutaneous leishmaniasis 30.60 9.74 15 191074 300 79552999
Product quality issue 30.57 9.74 22 191067 33918 79519381
Anorectal stenosis 30.54 9.74 9 191080 38 79553261
Chest pain 30.52 9.74 484 190605 281820 79271479
Delusion 30.35 9.74 6 191083 20417 79532882
Pulmonary mass 30.34 9.74 144 190945 28890 79524409
Disease progression 30.19 9.74 289 190800 184073 79369226
Angioedema 30.18 9.74 88 191001 75947 79477352
Foetal growth restriction 30.16 9.74 31 191058 2088 79551211
Faecal calprotectin abnormal 30.14 9.74 13 191076 191 79553108
Enterovesical fistula 30.12 9.74 24 191065 1158 79552141
Therapy interrupted 30.00 9.74 19 191070 31322 79521977
Gastrointestinal mucosa hyperaemia 29.77 9.74 17 191072 468 79552831
Therapeutic product effect variable 29.71 9.74 30 191059 1979 79551320
Arrhythmia 29.70 9.74 64 191025 61208 79492091
Cytomegalovirus test positive 29.57 9.74 52 191037 5895 79547404
Gastrointestinal fistula 29.53 9.74 20 191069 749 79552550
Creatinine renal clearance decreased 29.49 9.74 5 191084 18997 79534302
Splenomegaly 29.49 9.74 113 190976 20641 79532658
Hypoxia 29.46 9.74 137 190952 103106 79450193
Atypical mycobacterial infection 29.45 9.74 28 191061 1715 79551584
Altered state of consciousness 29.43 9.74 37 191052 43785 79509514
Neoplasm skin 29.38 9.74 27 191062 1584 79551715
Therapy cessation 29.32 9.74 28 191061 37534 79515765
Electrolyte imbalance 29.17 9.74 19 191070 30862 79522437
Mycoplasma infection 29.07 9.74 20 191069 769 79552530
Withdrawal syndrome 29.00 9.74 14 191075 26840 79526459
Dry skin 29.00 9.74 76 191013 67919 79485380
Mydriasis 28.85 9.74 4 191085 17639 79535660
Hospitalisation 28.73 9.74 122 190967 94114 79459185
Cytomegalovirus infection reactivation 28.56 9.74 64 191025 8652 79544647
Rectal stenosis 28.47 9.74 15 191074 351 79552948
Ventricular fibrillation 28.36 9.74 21 191068 31905 79521394
Small intestinal resection 28.32 9.74 21 191068 910 79552389
Dyspnoea exertional 28.26 9.74 110 190979 86963 79466336
Heart rate decreased 28.24 9.74 275 190814 70041 79483258
Anorectal disorder 28.13 9.74 31 191058 2262 79551037
Lupus myocarditis 28.05 9.74 10 191079 85 79553214
Thrombotic microangiopathy 27.99 9.74 109 190980 20060 79533239
Device issue 27.98 9.74 15 191074 27093 79526206
Proctalgia 27.94 9.74 69 191020 9932 79543367
Cow pox 27.90 9.74 8 191081 30 79553269
Carcinoid tumour pulmonary 27.79 9.74 15 191074 369 79552930
Blister 27.72 9.74 170 190919 119306 79433993
Upper gastrointestinal haemorrhage 27.72 9.74 35 191054 41345 79511954
Complications of bone marrow transplant 27.71 9.74 18 191071 628 79552671
Gait disturbance 27.68 9.74 341 190748 207165 79346134
Synovial cyst 27.65 9.74 69 191020 9996 79543303
Mouth ulceration 27.64 9.74 172 190917 38222 79515077
Feeling abnormal 27.60 9.74 246 190843 158953 79394346
Rheumatoid factor positive 27.55 9.74 241 190848 59598 79493701
Systemic candida 27.53 9.74 54 191035 6652 79546647
Epstein-Barr virus infection reactivation 27.51 9.74 28 191061 1864 79551435
Squamous cell carcinoma of the tongue 27.49 9.74 19 191070 736 79552563
Intestinal anastomosis complication 27.47 9.74 14 191075 305 79552994
Complications of transplanted lung 27.46 9.74 16 191073 458 79552841
Rectal cancer metastatic 27.40 9.74 16 191073 460 79552839
Epstein-Barr viraemia 27.38 9.74 30 191059 2175 79551124
Bronchopulmonary aspergillosis 27.37 9.74 116 190973 22178 79531121
Sleep disorder 27.32 9.74 109 190980 85568 79467731
Chest discomfort 27.27 9.74 206 190883 137838 79415461
Lung infiltration 27.20 9.74 118 190971 22794 79530505
Pouchitis 27.19 9.74 21 191068 968 79552331
Urinary incontinence 26.99 9.74 35 191054 40874 79512425
Non-Hodgkin's lymphoma 26.98 9.74 25 191064 1482 79551817
Ganglioneuroma 26.92 9.74 11 191078 140 79553159
Palpitations 26.92 9.74 185 190904 126425 79426874
Blood sodium decreased 26.89 9.74 24 191065 33231 79520068
Tuberculosis of central nervous system 26.88 9.74 16 191073 477 79552822
Hypophagia 26.78 9.74 42 191047 45325 79507974
Depressed mood 26.65 9.74 47 191042 48433 79504866
Splenic abscess 26.54 9.74 17 191072 579 79552720
Ileectomy 26.45 9.74 12 191077 200 79553099
Neuromyelitis optica spectrum disorder 26.22 9.74 21 191068 1021 79552278
Myasthenia gravis 26.20 9.74 69 191020 10330 79542969
Muscle fatigue 26.15 9.74 37 191052 3482 79549817
Blood bilirubin increased 26.04 9.74 77 191012 66155 79487144
American trypanosomiasis 26.03 9.74 14 191075 342 79552957
Injection site mass 25.98 9.74 8 191081 20176 79533123
Systemic lupus erythematosus 25.84 9.74 421 190668 120728 79432571
Drug withdrawal syndrome 25.82 9.74 27 191062 34691 79518608
Extrapyramidal disorder 25.78 9.74 11 191078 22668 79530631
Epstein Barr virus positive mucocutaneous ulcer 25.77 9.74 19 191070 816 79552483
Swelling 25.67 9.74 365 190724 216346 79336953
Myasthenic syndrome 25.63 9.74 19 191070 823 79552476
Pollakiuria 25.59 9.74 31 191058 37286 79516013
Asthma 25.56 9.74 204 190885 134891 79418408
Renal transplant failure 25.53 9.74 27 191062 1880 79551419
Stevens-Johnson syndrome 25.34 9.74 34 191055 39132 79514167
Pseudopolyp 25.29 9.74 15 191074 444 79552855
Phospholipidosis 25.23 9.74 12 191077 224 79553075
Polyomavirus-associated nephropathy 25.17 9.74 47 191042 5580 79547719
Haematemesis 24.99 9.74 55 191034 52209 79501090
Serum sickness 24.99 9.74 37 191052 3629 79549670
Opportunistic infection 24.92 9.74 33 191056 2917 79550382
Listeria sepsis 24.81 9.74 18 191071 754 79552545
Weight increased 24.81 9.74 854 190235 276532 79276767
Lymphadenopathy 24.80 9.74 215 190874 53032 79500267
Irritable bowel syndrome 24.73 9.74 72 191017 62169 79491130
Autoimmune haemolytic anaemia 24.67 9.74 59 191030 8321 79544978
Fear of injection 24.62 9.74 55 191034 7419 79545880
Anaphylactic shock 24.58 9.74 30 191059 35966 79517333
Pelvic abscess 24.56 9.74 28 191061 2121 79551178
Sepsis neonatal 24.56 9.74 8 191081 50 79553249
Stiff person syndrome 24.49 9.74 13 191076 309 79552990
Infection reactivation 24.44 9.74 31 191058 2626 79550673
Enterostomy 24.43 9.74 12 191077 241 79553058
Underdose 24.41 9.74 26 191063 33125 79520174
Pregnancy 24.39 9.74 128 190961 26723 79526576
Trichodysplasia spinulosa 24.39 9.74 18 191071 774 79552525
Nicotinic acid deficiency 24.38 9.74 11 191078 181 79553118
Intestinal mass 24.37 9.74 22 191067 1261 79552038
Tonsillar hypertrophy 24.34 9.74 24 191065 1538 79551761
Jaw fracture 24.34 9.74 33 191056 2984 79550315
Cytomegalovirus duodenitis 24.32 9.74 9 191080 86 79553213
Small intestine adenocarcinoma 24.32 9.74 11 191078 182 79553117
Troponin increased 24.13 9.74 8 191081 19247 79534052
Deep vein thrombosis 24.09 9.74 180 190909 120739 79432560
Anaplastic large cell lymphoma T- and null-cell types 24.08 9.74 10 191079 133 79553166
Pruritus 24.06 9.74 741 190348 393907 79159392
Dermatomyositis 23.89 9.74 36 191053 3587 79549712
Pneumonitis 23.75 9.74 71 191018 60789 79492510
Somatic delusion 23.66 9.74 17 191072 701 79552598
Swollen tongue 23.65 9.74 41 191048 42529 79510770
Retinal scar 23.62 9.74 14 191075 414 79552885
Hallucination, auditory 23.58 9.74 10 191079 20683 79532616
Femur fracture 23.57 9.74 35 191054 38617 79514682
Hypothyroidism 23.55 9.74 57 191032 52335 79500964
Dementia 23.53 9.74 15 191074 24644 79528655
Growth retardation 23.38 9.74 26 191063 1917 79551382
Splenic embolism 23.34 9.74 11 191078 201 79553098
Laryngeal disorder 23.23 9.74 20 191069 1076 79552223
Dermatitis psoriasiform 23.21 9.74 31 191058 2763 79550536
Neoplasm malignant 23.21 9.74 143 190946 31667 79521632
Leiomyosarcoma metastatic 23.03 9.74 6 191083 14 79553285
Meningoencephalitis viral 23.00 9.74 14 191075 435 79552864
Diffuse large B-cell lymphoma stage IV 23.00 9.74 15 191074 527 79552772
Conjunctivitis 22.96 9.74 122 190967 25593 79527706
Toxic epidermal necrolysis 22.93 9.74 45 191044 44536 79508763
Amnesia 22.89 9.74 76 191013 62981 79490318
Optic neuritis 22.81 9.74 62 191027 9458 79543841
Cytomegalovirus oesophagitis 22.80 9.74 17 191072 743 79552556
Abdominal pain upper 22.78 9.74 388 190701 223431 79329868
Hypersensitivity vasculitis 22.77 9.74 51 191038 6892 79546407
Injection site warmth 22.75 9.74 4 191085 14803 79538496
Adverse reaction 22.66 9.74 61 191028 9253 79544046
Hallucination, visual 22.64 9.74 27 191062 32702 79520597
Large intestinal ulcer 22.64 9.74 41 191048 4756 79548543
Rectal haemorrhage 22.63 9.74 281 190808 76019 79477280
Nephropathy toxic 22.61 9.74 103 190986 20316 79532983
Tinnitus 22.59 9.74 45 191044 44288 79509011
Intestinal dilatation 22.49 9.74 30 191059 2670 79550629
Periumbilical abscess 22.44 9.74 8 191081 68 79553231
Weber tuning fork test abnormal 22.35 9.74 9 191080 110 79553189
Primary biliary cholangitis 22.32 9.74 20 191069 1135 79552164
Myoclonus 22.32 9.74 20 191069 27640 79525659
Gastrooesophageal reflux disease 22.32 9.74 152 190937 104094 79449205
Exposure to SARS-CoV-2 22.30 9.74 26 191063 2018 79551281
Incorrect dose administered 22.20 9.74 281 190808 76349 79476950
Rash maculo-papular 22.18 9.74 65 191024 56013 79497286
Chronic myeloid leukaemia 22.18 9.74 35 191054 3629 79549670
Chronic hepatitis 22.12 9.74 22 191067 1425 79551874
Chronic gastrointestinal bleeding 22.06 9.74 14 191075 469 79552830
Acquired gene mutation 22.05 9.74 27 191062 2206 79551093
Device difficult to use 21.97 9.74 3 191086 13382 79539917
Encephalopathy 21.96 9.74 85 191004 67312 79485987
Subarachnoid haemorrhage 21.85 9.74 16 191073 24449 79528850
Skin exfoliation 21.70 9.74 64 191025 55036 79498263
Hip fracture 21.69 9.74 25 191064 30736 79522563
Tenderness 21.68 9.74 113 190976 23529 79529770
Head injury 21.68 9.74 35 191054 37334 79515965
Paracoccidioides infection 21.66 9.74 8 191081 76 79553223
Autoimmune neutropenia 21.59 9.74 15 191074 586 79552713
Pulmonary granuloma 21.52 9.74 26 191063 2095 79551204
Cholesteatoma 21.52 9.74 9 191080 122 79553177
Haematocrit decreased 21.50 9.74 75 191014 61237 79492062
Hepatic cytolysis 21.48 9.74 20 191069 27131 79526168
Blood potassium decreased 21.39 9.74 50 191039 46462 79506837
Arthritis reactive 21.30 9.74 15 191074 599 79552700
Tuberculosis of eye 21.30 9.74 8 191081 80 79553219
Ischaemic stroke 21.19 9.74 29 191060 33102 79520197
Febrile bone marrow aplasia 21.18 9.74 3 191086 13017 79540282
Rectal tenesmus 21.17 9.74 23 191066 1652 79551647
Abscess rupture 21.16 9.74 12 191077 326 79552973
Blood glucose decreased 21.14 9.74 19 191070 26215 79527084
Psychotic disorder 21.12 9.74 42 191047 41360 79511939
Salmonellosis 21.10 9.74 24 191065 1814 79551485
Hodgkin's disease 20.93 9.74 17 191072 843 79552456
Glomerulosclerosis 20.84 9.74 19 191070 1103 79552196
Lymphocytic infiltration 20.82 9.74 22 191067 1531 79551768
Infective pulmonary exacerbation of cystic fibrosis 20.81 9.74 3 191086 12848 79540451
Pneumonia legionella 20.65 9.74 30 191059 2892 79550407
Tonsillitis 20.56 9.74 48 191041 6666 79546633
Hyperthyroidism 20.53 9.74 14 191075 22195 79531104
Nightmare 20.51 9.74 19 191070 25842 79527457
Nodule 20.47 9.74 109 190980 22885 79530414
B-cell unclassifiable lymphoma high grade 20.42 9.74 5 191084 8 79553291
Eye infection toxoplasmal 20.35 9.74 14 191075 538 79552761
Drug level abnormal 20.33 9.74 12 191077 352 79552947
Dysphonia 20.33 9.74 69 191020 56803 79496496
Cutaneous nocardiosis 20.22 9.74 10 191079 204 79553095
Tonsil cancer 20.19 9.74 19 191070 1149 79552150
Fear 20.14 9.74 14 191075 21972 79531327
Graft versus host disease in lung 20.06 9.74 17 191072 895 79552404
Graft loss 20.04 9.74 18 191071 1025 79552274
Atrioventricular block first degree 20.03 9.74 3 191086 12488 79540811
Pyoderma 20.03 9.74 13 191076 453 79552846
Hepatitis viral 19.82 9.74 18 191071 1040 79552259
Blood cholesterol increased 19.77 9.74 296 190793 83424 79469875
HELLP syndrome 19.76 9.74 16 191073 790 79552509
Marrow hyperplasia 19.74 9.74 22 191067 1626 79551673
Flank pain 19.71 9.74 97 190992 19747 79533552
Drug interaction 19.71 9.74 804 190285 414379 79138920
Cytomegalovirus syndrome 19.69 9.74 11 191078 290 79553009
Aspiration 19.60 9.74 12 191077 20146 79533153
Atrial flutter 19.50 9.74 14 191075 21611 79531688
Sleep apnoea syndrome 19.48 9.74 36 191053 36442 79516857
Blood potassium increased 19.36 9.74 25 191064 29250 79524049
Hepatitis cholestatic 19.33 9.74 75 191014 13777 79539522
Scleroderma renal crisis 19.28 9.74 14 191075 587 79552712
Injection site haemorrhage 19.27 9.74 23 191066 27847 79525452
Pleural effusion 19.26 9.74 239 190850 145023 79408276
Muscle spasticity 19.24 9.74 14 191075 21461 79531838
Haemolysis 19.23 9.74 71 191018 12741 79540558
Dysplasia 19.23 9.74 20 191069 1366 79551933
Electrocardiogram abnormal 19.21 9.74 8 191081 16729 79536570
Antisynthetase syndrome 19.17 9.74 9 191080 163 79553136
Premature separation of placenta 19.15 9.74 19 191070 1227 79552072
Intestinal ulcer 19.10 9.74 24 191065 2014 79551285
Proctitis ulcerative 19.03 9.74 11 191078 310 79552989
Blood urea increased 18.98 9.74 57 191032 48733 79504566
Parkinsonism 18.92 9.74 8 191081 16576 79536723
Oedema 18.92 9.74 189 190900 119391 79433908
Foetal death 18.88 9.74 52 191037 7992 79545307
Eye ulcer 18.84 9.74 11 191078 316 79552983
Bronchitis 18.84 9.74 211 190878 130433 79422866
Abnormal faeces 18.83 9.74 50 191039 7521 79545778
Trichostasis spinulosa 18.81 9.74 5 191084 13 79553286
Peritoneal tuberculosis 18.80 9.74 13 191076 504 79552795
Tricuspid valve incompetence 18.80 9.74 12 191077 19700 79533599
Ventricular extrasystoles 18.78 9.74 12 191077 19692 79533607
Oxygen saturation decreased 18.78 9.74 208 190881 128839 79424460
Sebaceous adenoma 18.77 9.74 6 191083 35 79553264
Premature baby 18.72 9.74 33 191056 3747 79549552
Muscle twitching 18.71 9.74 19 191070 24745 79528554
Hot flush 18.67 9.74 68 191021 54809 79498490
Anastomotic stenosis 18.60 9.74 13 191076 513 79552786
Joint effusion 18.57 9.74 89 191000 17925 79535374
Stress at work 18.52 9.74 18 191071 1133 79552166
Adenocarcinoma of colon 18.51 9.74 41 191048 5500 79547799
Necrotising herpetic retinopathy 18.46 9.74 8 191081 119 79553180
Anger 18.45 9.74 9 191080 17153 79536146
Peripheral T-cell lymphoma unspecified stage IV 18.35 9.74 6 191083 38 79553261
Sleep disorder due to general medical condition, insomnia type 18.33 9.74 49 191040 43507 79509792
Porokeratosis 18.31 9.74 10 191079 252 79553047
Oral pain 18.24 9.74 30 191059 31768 79521531
Product storage error 18.24 9.74 8 191081 16218 79537081
Lethargy 18.17 9.74 117 190972 81175 79472124
Toxic skin eruption 18.13 9.74 16 191073 22277 79531022
Chorioretinitis 18.13 9.74 17 191072 1023 79552276
Spondylitis 18.11 9.74 37 191052 4694 79548605
Intestinal mucosal hypertrophy 18.06 9.74 11 191078 342 79552957
Bowel movement irregularity 18.01 9.74 44 191045 6290 79547009
Transient hypogammaglobulinaemia of infancy 17.97 9.74 6 191083 41 79553258
Cryptococcosis 17.96 9.74 31 191058 3462 79549837
Anogenital warts 17.71 9.74 16 191073 918 79552381
Palatal ulcer 17.71 9.74 8 191081 132 79553167
Kidney fibrosis 17.69 9.74 31 191058 3504 79549795
Salivary hypersecretion 17.66 9.74 6 191083 14218 79539081
Eosinophilia 17.62 9.74 53 191036 45292 79508007
Colectomy total 17.56 9.74 11 191078 360 79552939
Polyuria 17.52 9.74 7 191082 15007 79538292
Gastrointestinal bacterial infection 17.40 9.74 16 191073 939 79552360
Product administration error 17.39 9.74 31 191058 31815 79521484
Burkitt's lymphoma stage III 17.38 9.74 5 191084 19 79553280
Pseudoxanthoma elasticum-like syndrome 17.38 9.74 4 191085 4 79553295
Cardiotoxicity 17.36 9.74 4 191085 12235 79541064
Oral lichen planus 17.36 9.74 15 191074 811 79552488
Thinking abnormal 17.33 9.74 5 191084 13156 79540143
Dysphagia 17.32 9.74 198 190891 121938 79431361
Mycoplasma test positive 17.30 9.74 9 191080 205 79553094
Angina unstable 17.27 9.74 9 191080 16518 79536781
Mucormycosis 17.22 9.74 52 191037 8417 79544882
Cervix carcinoma 17.21 9.74 24 191065 2229 79551070
Cyanosis 17.18 9.74 21 191068 25161 79528138
Steroid dependence 17.15 9.74 26 191063 2604 79550695
Gestational diabetes 17.14 9.74 43 191046 6250 79547049
Tractional retinal detachment 17.14 9.74 7 191082 89 79553210
Pulmonary congestion 17.05 9.74 24 191065 27076 79526223
Acute respiratory failure 16.99 9.74 79 191010 59462 79493837
Respiratory gas exchange disorder 16.97 9.74 15 191074 836 79552463
Blood creatine phosphokinase increased 16.96 9.74 91 190998 65999 79487300
Gastrointestinal obstruction 16.82 9.74 21 191068 1751 79551548
Pharyngeal oedema 16.80 9.74 9 191080 16263 79537036
Pseudopolyposis 16.80 9.74 7 191082 94 79553205
Prostate cancer 16.75 9.74 34 191055 33234 79520065
Oesophageal squamous cell carcinoma 16.72 9.74 12 191077 494 79552805
Vertigo 16.71 9.74 97 190992 68985 79484314
Presyncope 16.67 9.74 47 191042 41007 79512292
Drug specific antibody absent 16.65 9.74 9 191080 222 79553077
Diarrhoea 16.62 9.74 1852 189237 878637 78674662
Lymph node tuberculosis 16.59 9.74 16 191073 998 79552301
Generalised tonic-clonic seizure 16.58 9.74 52 191037 43858 79509441
Small intestine operation 16.53 9.74 6 191083 54 79553245
Aspergillosis oral 16.53 9.74 6 191083 54 79553245
Antineutrophil cytoplasmic antibody increased 16.51 9.74 9 191080 226 79553073
Microscopic polyangiitis 16.48 9.74 11 191078 402 79552897
Cervical dysplasia 16.47 9.74 23 191066 2138 79551161
Hodgkin's disease nodular sclerosis 16.45 9.74 5 191084 24 79553275
Ileal perforation 16.44 9.74 16 191073 1009 79552290
Viral test positive 16.41 9.74 11 191078 405 79552894
Cough 16.41 9.74 715 190374 366074 79187225
Small intestine carcinoma 16.30 9.74 16 191073 1020 79552279
Renal failure 16.29 9.74 362 190727 200606 79352693
Second primary malignancy 16.25 9.74 7 191082 14343 79538956
Disseminated cryptococcosis 16.24 9.74 21 191068 1813 79551486
Herpes simplex 16.21 9.74 65 191024 12122 79541177
Acute coronary syndrome 16.21 9.74 16 191073 21117 79532182
Lupus endocarditis 16.19 9.74 9 191080 235 79553064
Mediastinal effusion 16.15 9.74 6 191083 58 79553241
Anti-erythropoietin antibody negative 16.14 9.74 10 191079 321 79552978
Acne conglobata 16.12 9.74 5 191084 26 79553273
Muscular dystrophy 16.05 9.74 8 191081 166 79553133
Cytomegalovirus hepatitis 16.00 9.74 14 191075 770 79552529
Malignant polyp 15.88 9.74 8 191081 170 79553129
Stenosis 15.87 9.74 24 191065 2398 79550901
Brain stem syndrome 15.86 9.74 15 191074 913 79552386
Intestinal fibrosis 15.84 9.74 8 191081 171 79553128
Hirsutism 15.79 9.74 18 191071 1364 79551935
Diabetes mellitus inadequate control 15.76 9.74 21 191068 24243 79529056
Enteritis 15.73 9.74 73 191016 14510 79538789
Polyhydramnios 15.71 9.74 20 191069 1700 79551599
Bacillary angiomatosis 15.69 9.74 9 191080 250 79553049
Gastrointestinal ulcer 15.69 9.74 29 191060 3417 79549882
Cerebral haemorrhage 15.59 9.74 78 191011 57595 79495704
Metastases to central nervous system 15.57 9.74 10 191079 16365 79536934
Necrotising retinitis 15.57 9.74 17 191072 1228 79552071
Hyperlipidaemia 15.55 9.74 24 191065 26069 79527230
Testicular cancer metastatic 15.55 9.74 6 191083 65 79553234
Mesenteritis 15.52 9.74 10 191079 344 79552955
Enthesopathy 15.51 9.74 62 191027 11546 79541753
Dystonia 15.51 9.74 17 191072 21382 79531917
Night sweats 15.50 9.74 192 190897 51903 79501396
Acne 15.50 9.74 115 190974 27075 79526224
Leiomyosarcoma 15.47 9.74 10 191079 346 79552953
Arteriosclerosis coronary artery 15.47 9.74 12 191077 17804 79535495
Sebaceous carcinoma 15.41 9.74 7 191082 117 79553182
Myelosuppression 15.40 9.74 156 190933 40140 79513159
Exercise tolerance increased 15.39 9.74 5 191084 31 79553268
Gastrointestinal scarring 15.37 9.74 10 191079 350 79552949
Fistula of small intestine 15.35 9.74 14 191075 813 79552486
Pulmonary thrombosis 15.35 9.74 5 191084 12166 79541133
Sinusitis 15.32 9.74 354 190735 195147 79358152
Ileocaecal resection 15.31 9.74 7 191082 119 79553180
IgA nephropathy 15.28 9.74 20 191069 1748 79551551
Anastomotic complication 15.20 9.74 11 191078 459 79552840
Carotid artery perforation 15.16 9.74 4 191085 10 79553289
Feeling jittery 15.14 9.74 66 191023 12775 79540524
Ileal ulcer 15.13 9.74 16 191073 1114 79552185
Red blood cell sedimentation rate 15.13 9.74 38 191051 5527 79547772
Lower gastrointestinal haemorrhage 15.13 9.74 10 191079 16115 79537184
Sudden death 15.12 9.74 19 191070 22492 79530807
Neutrophilic dermatosis 15.08 9.74 12 191077 578 79552721
Psychomotor hyperactivity 15.07 9.74 11 191078 16838 79536461
Narcotic bowel syndrome 15.04 9.74 9 191080 271 79553028
Sideroblastic anaemia 15.01 9.74 9 191080 272 79553027
Laryngeal mass 15 9.74 6 191083 72 79553227
Mucocutaneous leishmaniasis 14.99 9.74 11 191078 469 79552830
Mania 14.98 9.74 13 191076 18247 79535052
Enzyme abnormality 14.97 9.74 10 191079 366 79552933
Vasculitis necrotising 14.96 9.74 17 191072 1283 79552016
Thymoma 14.92 9.74 9 191080 275 79553024
Complication associated with device 14.92 9.74 12 191077 17484 79535815
Trichosporon infection 14.81 9.74 15 191074 993 79552306
Diaphragmatic injury 14.80 9.74 7 191082 129 79553170
Eosinophilic bronchitis 14.75 9.74 11 191078 481 79552818
Injection site pruritus 14.64 9.74 52 191037 42231 79511068
Tinea capitis 14.63 9.74 4 191085 12 79553287
Placental necrosis 14.63 9.74 4 191085 12 79553287
Coordination abnormal 14.60 9.74 12 191077 17300 79535999
Necrosis 14.58 9.74 53 191036 9440 79543859
Pyometra 14.57 9.74 6 191083 78 79553221
Hypergammaglobulinaemia 14.57 9.74 13 191076 734 79552565
Corynebacterium infection 14.57 9.74 17 191072 1321 79551978
Drug resistance 14.53 9.74 160 190929 42053 79511246
Proctitis 14.53 9.74 41 191048 6391 79546908
DNA antibody 14.51 9.74 5 191084 38 79553261
Impaired healing 14.51 9.74 137 190952 87518 79465781
Speech disorder 14.51 9.74 74 191015 54371 79498928
Perirectal abscess 14.49 9.74 21 191068 2020 79551279
Adenocarcinoma of the cervix 14.49 9.74 8 191081 206 79553093
Dengue fever 14.46 9.74 14 191075 877 79552422
Cystitis 14.44 9.74 71 191018 52661 79500638
Duodenal ulcer perforation 14.44 9.74 96 190993 66115 79487184
Sinus tachycardia 14.44 9.74 43 191046 36865 79516434
Osteomyelitis 14.42 9.74 131 190958 32734 79520565
Mycetoma mycotic 14.42 9.74 7 191082 137 79553162
Inflammatory pain 14.40 9.74 15 191074 1026 79552273
Female genital tract fistula 14.40 9.74 39 191050 5936 79547363
Mitochondrial neurogastrointestinal encephalopathy 14.39 9.74 4 191085 13 79553286
Herpes zoster meningoencephalitis 14.36 9.74 13 191076 748 79552551
Injection site induration 14.35 9.74 3 191086 9816 79543483
Hidradenitis 14.34 9.74 26 191063 3018 79550281
Hiatus hernia 14.32 9.74 21 191068 23291 79530008
Obstructive airways disorder 14.32 9.74 34 191055 31425 79521874
Cystitis escherichia 14.30 9.74 12 191077 623 79552676
Glycosylated haemoglobin increased 14.30 9.74 15 191074 19245 79534054
Rotator cuff syndrome 14.26 9.74 8 191081 14087 79539212
Hypophosphataemia 14.24 9.74 16 191073 19897 79533402
Deformity 14.23 9.74 53 191036 9552 79543747
Listeria encephalitis 14.22 9.74 9 191080 300 79552999
Product dispensing error 14.19 9.74 7 191082 13256 79540043
Akathisia 14.19 9.74 7 191082 13252 79540047
Retinal injury 14.17 9.74 9 191080 302 79552997
Drain site complication 14.16 9.74 4 191085 14 79553285
Haemophilus infection 14.14 9.74 22 191067 2254 79551045
Epstein-Barr virus antibody positive 14.11 9.74 12 191077 635 79552664
Cardiac valve vegetation 14.10 9.74 14 191075 905 79552394
Epiglottic erythema 14.08 9.74 5 191084 42 79553257
Biopsy muscle abnormal 14.08 9.74 5 191084 42 79553257
Skin hyperpigmentation 14.07 9.74 44 191045 7259 79546040
Focal segmental glomerulosclerosis 13.94 9.74 27 191062 3294 79550005
Drain placement 13.93 9.74 7 191082 148 79553151
Tuberous sclerosis complex 13.92 9.74 6 191083 88 79553211
Lymphadenitis bacterial 13.92 9.74 6 191083 88 79553211
Skin cancer 13.87 9.74 72 191017 14968 79538331
Henoch-Schonlein purpura 13.87 9.74 24 191065 2686 79550613
Abnormal dreams 13.85 9.74 5 191084 11407 79541892
Blood pressure increased 13.79 9.74 629 190460 210731 79342568
Skin papilloma 13.77 9.74 38 191051 5848 79547451
Herpes simplex test positive 13.76 9.74 10 191079 420 79552879
Whipple's disease 13.75 9.74 4 191085 16 79553283
Ureteral neoplasm 13.75 9.74 4 191085 16 79553283
Pulmonary paracoccidioidomycosis 13.75 9.74 4 191085 16 79553283
Laparotomy 13.70 9.74 10 191079 423 79552876
Faeces discoloured 13.64 9.74 31 191058 29096 79524203
Appendicectomy 13.62 9.74 24 191065 2724 79550575
Adrenal insufficiency 13.60 9.74 30 191059 28457 79524842
Prostatic specific antigen increased 13.58 9.74 4 191085 10382 79542917
Photophobia 13.57 9.74 90 190999 20438 79532861
Hepatitis G 13.55 9.74 4 191085 17 79553282
Enterocolonic fistula 13.55 9.74 7 191082 157 79553142
Anorectal discomfort 13.53 9.74 28 191061 3583 79549716
Joint tuberculosis 13.51 9.74 7 191082 158 79553141
Blood phosphorus increased 13.50 9.74 4 191085 10343 79542956
Paranoia 13.48 9.74 16 191073 19416 79533883
Hypertensive crisis 13.47 9.74 18 191071 20752 79532547
Hospice care 13.45 9.74 4 191085 10320 79542979
Acinetobacter infection 13.44 9.74 24 191065 2753 79550546
Onychomycosis 13.44 9.74 47 191042 8214 79545085
Leiomyoma 13.39 9.74 9 191080 333 79552966
Glomerulonephritis 13.32 9.74 27 191062 3406 79549893
Primary effusion lymphoma 13.31 9.74 5 191084 50 79553249
Taste disorder 13.31 9.74 11 191078 15812 79537487
Diffuse large B-cell lymphoma stage III 13.28 9.74 6 191083 99 79553200
Infertility 13.28 9.74 12 191077 689 79552610
Folliculitis 13.26 9.74 78 191011 55302 79497997
Peripheral artery aneurysm 13.23 9.74 10 191079 446 79552853
Cardiomegaly 13.21 9.74 27 191062 26325 79526974
Hepatitis B 13.21 9.74 47 191042 8285 79545014
Infusion site thrombosis 13.16 9.74 8 191081 248 79553051
Gastrointestinal oedema 13.16 9.74 23 191066 2595 79550704
Acute pulmonary oedema 13.11 9.74 9 191080 14221 79539078
Skin abrasion 13.10 9.74 8 191081 13448 79539851
Drug specific antibody 13.09 9.74 23 191066 2605 79550694
Bone density decreased 13.08 9.74 65 191024 13282 79540017
Lung neoplasm 13.08 9.74 42 191047 7027 79546272
Oesophagopleural fistula 13.05 9.74 5 191084 53 79553246
Precursor T-lymphoblastic lymphoma/leukaemia stage I 13.04 9.74 3 191086 3 79553296
Enterostomy closure 13.04 9.74 3 191086 3 79553296
Faecaluria 13.04 9.74 3 191086 3 79553296
Gastrointestinal stoma complication 13.03 9.74 23 191066 2614 79550685
Peritoneal candidiasis 13.03 9.74 4 191085 20 79553279
Mycobacterium kansasii infection 12.92 9.74 9 191080 353 79552946
Urinary tract infection 12.92 9.74 532 190557 273980 79279319
Metastatic malignant melanoma 12.92 9.74 24 191065 2839 79550460
Gastrointestinal stoma output abnormal 12.86 9.74 6 191083 107 79553192
Butterfly rash 12.85 9.74 18 191071 1678 79551621
Helicobacter infection 12.84 9.74 106 190983 69598 79483701
Pseudomonas infection 12.83 9.74 90 190999 20813 79532486
Anal skin tags 12.83 9.74 10 191079 467 79552832
Apnoea 12.80 9.74 6 191083 11698 79541601
Burning sensation 12.79 9.74 85 191004 58547 79494752
Retinal vasculitis 12.78 9.74 16 191073 1337 79551962
Impetigo 12.75 9.74 20 191069 2063 79551236
Complications of transplanted heart 12.75 9.74 9 191080 361 79552938
Gastric ulcer haemorrhage 12.71 9.74 3 191086 9024 79544275
Cholecystitis chronic 12.62 9.74 4 191085 9902 79543397
Germ cell cancer 12.59 9.74 7 191082 183 79553116
Gamma-glutamyltransferase increased 12.58 9.74 78 191011 54602 79498697
Erectile dysfunction 12.57 9.74 10 191079 14654 79538645
Meningeal neoplasm 12.56 9.74 4 191085 23 79553276
Respiratory tract infection fungal 12.52 9.74 15 191074 1198 79552101
Device malfunction 12.52 9.74 20 191069 21428 79531871
Product monitoring error 12.46 9.74 3 191086 8903 79544396
Threatened labour 12.45 9.74 11 191078 613 79552686
Unevaluable event 12.42 9.74 80 191009 55505 79497794
Device breakage 12.42 9.74 5 191084 10670 79542629
Shock haemorrhagic 12.39 9.74 18 191071 20042 79533257
Failed induction of labour 12.37 9.74 8 191081 277 79553022
Skin mass 12.37 9.74 45 191044 8018 79545281
Neuropsychiatric lupus 12.35 9.74 7 191082 190 79553109
Left ventricular dysfunction 12.33 9.74 17 191072 19344 79533955
Klebsiella infection 12.32 9.74 72 191017 15648 79537651
Laser therapy 12.28 9.74 4 191085 25 79553274
Tongue disorder 12.27 9.74 66 191023 13909 79539390
Weight fluctuation 12.27 9.74 58 191031 11617 79541682
Torsade de pointes 12.26 9.74 17 191072 19295 79534004
Blood thyroid stimulating hormone increased 12.22 9.74 4 191085 9704 79543595
Blood glucose abnormal 12.21 9.74 5 191084 10561 79542738
Hepatitis E 12.20 9.74 24 191065 2962 79550337
Foetal exposure during pregnancy 12.20 9.74 36 191053 5754 79547545
Eye pruritus 12.18 9.74 19 191070 20551 79532748
Gastrointestinal dilation procedure 12.18 9.74 3 191086 5 79553294
Pulmonary function test increased 12.18 9.74 3 191086 5 79553294
Heparin-induced thrombocytopenia 12.17 9.74 4 191085 9678 79543621
Peripheral swelling 12.17 9.74 525 190564 269092 79284207
Gastroenterostomy 12.14 9.74 5 191084 65 79553234
Burkitt's lymphoma 12.10 9.74 6 191083 123 79553176
Synovial disorder 12.09 9.74 19 191070 1964 79551335
Oesophagitis 12.08 9.74 25 191064 24264 79529035
Crying 12.08 9.74 23 191066 23020 79530279
Mood altered 12.05 9.74 15 191074 17832 79535467
Renal cell carcinoma stage III 12.02 9.74 4 191085 27 79553272
Fungal peritonitis 12.01 9.74 14 191075 1086 79552213
Myelitis 12.01 9.74 21 191068 2370 79550929
Femoral artery aneurysm 11.99 9.74 7 191082 201 79553098
Dry mouth 11.97 9.74 144 190945 87875 79465424
Affect lability 11.96 9.74 6 191083 11253 79542046
Pancreatitis acute 11.95 9.74 176 190913 49428 79503871
Drug withdrawal syndrome neonatal 11.92 9.74 8 191081 295 79553004
Polymyositis 11.92 9.74 24 191065 3012 79550287
Gastrointestinal motility disorder 11.90 9.74 37 191052 6085 79547214
Infective tenosynovitis 11.90 9.74 9 191080 402 79552897
Cutaneous T-cell lymphoma stage III 11.89 9.74 4 191085 28 79553271
Glossodynia 11.89 9.74 175 190914 103162 79450137
Visual impairment 11.88 9.74 297 190792 91834 79461465
Cryoglobulins present 11.83 9.74 3 191086 6 79553293
Anaplastic large cell lymphoma T- and null-cell types stage III 11.83 9.74 3 191086 6 79553293
Acute haemorrhagic ulcerative colitis 11.83 9.74 3 191086 6 79553293
Actinic cheilitis 11.83 9.74 3 191086 6 79553293
Actinomycotic skin infection 11.83 9.74 3 191086 6 79553293
Hypovolaemia 11.81 9.74 15 191074 17676 79535623
Anovulatory cycle 11.80 9.74 6 191083 130 79553169
Intestinal operation 11.79 9.74 10 191079 527 79552772
Epilepsy 11.78 9.74 54 191035 40806 79512493
Arthritis enteropathic 11.78 9.74 8 191081 301 79552998
Meningitis aseptic 11.78 9.74 40 191049 6888 79546411
Rectal cancer 11.74 9.74 26 191063 3487 79549812
Cardiac failure chronic 11.73 9.74 6 191083 11129 79542170
Infected fistula 11.72 9.74 9 191080 411 79552888
Stoma complication 11.69 9.74 12 191077 807 79552492
Sacroiliitis 11.67 9.74 27 191062 3727 79549572
Abdominal pain lower 11.65 9.74 122 190967 31660 79521639
Haematuria 11.65 9.74 107 190982 68729 79484570
Oesophageal carcinoma 11.64 9.74 6 191083 11078 79542221
Injury 11.63 9.74 124 190965 77372 79475927
Nerve injury 11.60 9.74 4 191085 9388 79543911
Antineutrophil cytoplasmic antibody decreased 11.54 9.74 4 191085 31 79553268
Paraproteinaemia 11.54 9.74 9 191080 421 79552878
Human ehrlichiosis 11.47 9.74 10 191079 547 79552752
Retching 11.47 9.74 15 191074 17452 79535847
Psoriatic arthropathy 11.45 9.74 256 190833 77743 79475556
DNA antibody positive 11.44 9.74 8 191081 316 79552983
Cellulitis 11.43 9.74 188 190901 108872 79444427
Urticaria 11.40 9.74 548 190541 184653 79368646
Lentigo maligna 11.40 9.74 10 191079 552 79552747
Skin striae 11.38 9.74 18 191071 1870 79551429
Herpes virus infection 11.38 9.74 40 191049 7009 79546290
Asphyxia 11.36 9.74 7 191082 11713 79541586
Abdominal discomfort 11.36 9.74 488 190601 250239 79303060
Headache 11.30 9.74 1383 189706 652389 78900910
Intestinal polyp 11.25 9.74 19 191070 2085 79551214
Anastomotic fistula 11.25 9.74 6 191083 144 79553155
Spindle cell sarcoma 11.23 9.74 7 191082 227 79553072
Joint dislocation reduction 11.22 9.74 4 191085 34 79553265
Lacrimal haemorrhage 11.22 9.74 4 191085 34 79553265
Enterobacter infection 11.22 9.74 30 191059 4532 79548767
Pneumonia cryptococcal 11.20 9.74 16 191073 1519 79551780
Hypercalcaemia 11.16 9.74 141 190948 38289 79515010
Varicella zoster pneumonia 11.14 9.74 6 191083 147 79553152
Connective tissue disorder 11.13 9.74 15 191074 1348 79551951
Diastolic dysfunction 11.13 9.74 6 191083 10805 79542494
Cholangitis chronic 11.12 9.74 4 191085 35 79553264
Small intestine ulcer 11.12 9.74 11 191078 708 79552591
Back disorder 11.11 9.74 7 191082 11571 79541728
Skin fissures 11.10 9.74 9 191080 13064 79540235
Needle issue 11.09 9.74 9 191080 13059 79540240
Abscess neck 11.06 9.74 14 191075 1183 79552116
Dizziness postural 11.05 9.74 7 191082 11542 79541757
Anaemia macrocytic 11.04 9.74 34 191055 5563 79547736
Anal ulcer 11.01 9.74 15 191074 1363 79551936
Ophthalmic herpes simplex 10.98 9.74 11 191078 719 79552580
Haemorrhage foetal 10.97 9.74 3 191086 9 79553290
Primary mediastinal large B-cell lymphoma stage IV 10.97 9.74 3 191086 9 79553290
Myelitis transverse 10.97 9.74 18 191071 1929 79551370
Anal squamous cell carcinoma 10.95 9.74 10 191079 582 79552717
Neuritis 10.93 9.74 17 191072 1741 79551558
Nocturia 10.91 9.74 10 191079 13671 79539628
Complement factor C4 decreased 10.88 9.74 8 191081 342 79552957
Skin neoplasm excision 10.87 9.74 13 191076 1037 79552262
Dyspepsia 10.86 9.74 189 190900 108498 79444801
Pseudomonas aeruginosa meningitis 10.83 9.74 4 191085 38 79553261
Hypothermia 10.82 9.74 24 191065 22722 79530577
Cryptosporidiosis infection 10.81 9.74 11 191078 732 79552567
Product substitution issue 10.81 9.74 20 191069 20236 79533063
Musculoskeletal discomfort 10.80 9.74 83 191006 19752 79533547
Tumour lysis syndrome 10.79 9.74 26 191063 23913 79529386
Tongue ulceration 10.75 9.74 28 191061 4165 79549134
Graft complication 10.74 9.74 11 191078 738 79552561
Foetal anaemia 10.73 9.74 3 191086 10 79553289
Retinal toxicity 10.73 9.74 15 191074 1396 79551903
Gastrointestinal stenosis 10.71 9.74 7 191082 247 79553052
Bradykinesia 10.69 9.74 3 191086 8040 79545259
Vascular graft complication 10.68 9.74 6 191083 160 79553139
Vitello-intestinal duct remnant 10.68 9.74 6 191083 160 79553139
COVID-19 10.67 9.74 471 190618 157203 79396096
Malaise 10.66 9.74 1335 189754 488534 79064765
Metastases to bone 10.65 9.74 27 191062 24400 79528899
Epistaxis 10.63 9.74 346 190743 111169 79442130
Total bile acids increased 10.58 9.74 5 191084 92 79553207
Herpes simplex colitis 10.56 9.74 4 191085 41 79553258
B-cell lymphoma stage IV 10.53 9.74 5 191084 93 79553206
Immunodeficiency common variable 10.52 9.74 8 191081 360 79552939
Molluscum contagiosum 10.52 9.74 9 191080 480 79552819
Blood loss anaemia 10.49 9.74 13 191076 15485 79537814
Supraventricular tachycardia 10.49 9.74 22 191067 21248 79532051
Superinfection viral 10.48 9.74 4 191085 42 79553257
Renal atrophy 10.46 9.74 17 191072 1808 79551491
Oropharyngeal squamous cell carcinoma 10.41 9.74 7 191082 259 79553040
Hyperventilation 10.40 9.74 3 191086 7896 79545403
Quality of life decreased 10.39 9.74 51 191038 10369 79542930
Fungal skin infection 10.39 9.74 35 191054 6001 79547298
Hepatic infection bacterial 10.39 9.74 4 191085 43 79553256
Blood calcium increased 10.38 9.74 6 191083 10394 79542905
Panic attack 10.37 9.74 27 191062 24189 79529110
Infection 10.37 9.74 692 190397 241020 79312279
Mycobacterium chelonae infection 10.35 9.74 20 191069 2436 79550863
Atrioventricular block 10.35 9.74 11 191078 14030 79539269
Drug-induced liver injury 10.34 9.74 219 190870 65898 79487401
Complement factor C3 decreased 10.33 9.74 8 191081 370 79552929
Rash pustular 10.33 9.74 54 191035 11257 79542042
Myositis 10.32 9.74 80 191009 19088 79534211
Ketoacidosis 10.31 9.74 3 191086 7851 79545448
Sinonasal papilloma 10.31 9.74 4 191085 44 79553255
Hepatobiliary cancer 10.31 9.74 3 191086 12 79553287
Uveal melanoma 10.31 9.74 3 191086 12 79553287
Respiratory symptom 10.30 9.74 30 191059 4761 79548538
Cytomegalovirus enterocolitis 10.28 9.74 16 191073 1639 79551660
Colitis ischaemic 10.28 9.74 13 191076 15346 79537953
Osteoarthritis 10.25 9.74 278 190811 87031 79466268
Renal tubular atrophy 10.24 9.74 17 191072 1839 79551460
Pneumonia herpes viral 10.23 9.74 6 191083 174 79553125
Foetal malpresentation 10.20 9.74 5 191084 100 79553199
Scedosporium infection 10.19 9.74 15 191074 1463 79551836
Incorrect route of product administration 10.17 9.74 46 191043 34883 79518416
Circulatory collapse 10.15 9.74 51 191038 37617 79515682
Infusion site paraesthesia 10.12 9.74 3 191086 13 79553286
Spleen palpable 10.12 9.74 3 191086 13 79553286
Euphoric mood 10.06 9.74 3 191086 7723 79545576
Sinus node dysfunction 10.00 9.74 3 191086 7698 79545601
Infective aortitis 10 9.74 4 191085 48 79553251
Pharyngitis bacterial 10.00 9.74 7 191082 277 79553022
Isosporiasis 9.99 9.74 6 191083 182 79553117
Discomfort 9.97 9.74 227 190862 125390 79427909
Arterial rupture 9.96 9.74 11 191078 805 79552494
Panniculitis lobular 9.93 9.74 4 191085 49 79553250
Transplant failure 9.92 9.74 29 191060 4612 79548687
Pulmonary hypertension 9.85 9.74 71 191018 48009 79505290
Humerus fracture 9.84 9.74 5 191084 9308 79543991
Amniotic cavity infection 9.84 9.74 11 191078 816 79552483
Concussion 9.83 9.74 47 191042 9456 79543843
Device leakage 9.83 9.74 7 191082 10849 79542450
Hepatic fibrosis 9.82 9.74 39 191050 7241 79546058
Emotional disorder 9.81 9.74 12 191077 14375 79538924
Gastric fistula 9.81 9.74 6 191083 188 79553111
Central nervous system necrosis 9.80 9.74 7 191082 286 79553013
Cutaneous lupus erythematosus 9.78 9.74 22 191067 2981 79550318
Cushing's syndrome 9.78 9.74 12 191077 983 79552316
Deafness transitory 9.78 9.74 12 191077 983 79552316
Metastases to nasal sinuses 9.77 9.74 3 191086 15 79553284
Immune-mediated myositis 9.77 9.74 24 191065 3443 79549856
Liver sarcoidosis 9.77 9.74 3 191086 15 79553284
Abscess limb 9.77 9.74 38 191051 6989 79546310

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hydrops foetalis 56.73 35.01 17 200 80 89495

Pharmacologic Action:

SourceCodeDescription
ATC L04AX01 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
IMMUNOSUPPRESSANTS
IMMUNOSUPPRESSANTS
Other immunosuppressants
FDA CS M0015066 Nucleosides
FDA CS M0018169 Purines
FDA MoA N0000000233 Nucleic Acid Synthesis Inhibitors
MeSH PA D000963 Antimetabolites
MeSH PA D000964 Antimetabolites, Antineoplastic
MeSH PA D000970 Antineoplastic Agents
MeSH PA D018501 Antirheumatic Agents
MeSH PA D007155 Immunologic Factors
MeSH PA D007166 Immunosuppressive Agents
MeSH PA D009676 Noxae
FDA EPC N0000175712 Purine Antimetabolite

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Refractory idiopathic thrombocytopenic purpura indication 13172003
Relapsing multiple sclerosis indication 24700007 DOID:2377
Crohn's disease indication 34000006
Pemphigus vulgaris indication 49420001 DOID:0060851
Systemic lupus erythematosus indication 55464009 DOID:9074
Ulcerative colitis indication 64766004 DOID:8577
Rheumatoid arthritis indication 69896004 DOID:7148
Bullous pemphigoid indication 77090002 DOID:8506
Myasthenia gravis indication 91637004 DOID:437
Polyarteritis nodosa indication 155441006 DOID:9810
Behcet's disease indication 310701003 DOID:13241
Dermatomyositis indication 396230008 DOID:10223
Autoimmune hepatitis indication 408335007
Refractory autoimmune haemolytic anaemia indication 413603009 DOID:718
Prevention of Kidney Transplant Rejection indication
Polymyositis off-label use 31384009
Prevention of Lung Transplant Rejection off-label use
Prevention of Cardiac Transplant Rejection off-label use
Prevention of Liver Transplant Rejection off-label use
Mycosis contraindication 3218000 DOID:1564
Viral disease contraindication 34014006 DOID:934
Hepatic vein thrombosis contraindication 38739001 DOID:11512
Bacterial infectious disease contraindication 87628006
Malignant lymphoma contraindication 118600007 DOID:0060058
Liver function tests abnormal contraindication 166603001
Acute pancreatitis contraindication 197456007 DOID:2913
Impaired renal function disorder contraindication 197663003
Anemia contraindication 271737000 DOID:2355
Pregnancy, function contraindication 289908002
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Bone marrow depression contraindication 307762000
Hepatosplenic T-cell lymphoma contraindication 445406001
Thiopurine S-Methyltransferase Deficiency contraindication
Severe Leukopenia contraindication
Protozoal Infection contraindication




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.28 acidic
pKa2 3.24 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
ATP-binding cassette sub-family G member 2 Transporter WOMBAT-PK
Multidrug resistance-associated protein 5 Transporter WOMBAT-PK
Multidrug resistance-associated protein 4 Transporter WOMBAT-PK
Ras-related C3 botulinum toxin substrate 1 Enzyme WOMBAT-PK
Thiopurine S-methyltransferase Enzyme WOMBAT-PK

External reference:

IDSource
4018766 VUID
N0000147069 NUI
D00238 KEGG_DRUG
55774-33-9 SECONDARY_CAS_RN
1256 RXNORM
C0004482 UMLSCUI
CHEMBL1542 ChEMBL_ID
DB00993 DRUGBANK_ID
D001379 MESH_DESCRIPTOR_UI
2265 PUBCHEM_CID
7120 IUPHAR_LIGAND_ID
1291 INN_ID
MRK240IY2L UNII
3341 MMSL
4234 MMSL
4235 MMSL
6041 MMSL
d00024 MMSL
111165009 SNOMEDCT_US
372574004 SNOMEDCT_US
67221004 SNOMEDCT_US
CHEMBL1200400 ChEMBL_ID
4018766 VANDF
003419 NDDF
004123 NDDF

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Azathioprine Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0143-9566 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 100 mg INTRAVENOUS ANDA 22 sections
Azathioprine Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0143-9566 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 100 mg INTRAVENOUS ANDA 22 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 0378-1005 TABLET 50 mg ORAL ANDA 23 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 21695-484 TABLET 50 mg ORAL ANDA 20 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 33261-758 TABLET 50 mg ORAL ANDA 20 sections
AZATHIOPRINE HUMAN PRESCRIPTION DRUG LABEL 1 42291-063 TABLET 100 mg ORAL ANDA 19 sections
AZATHIOPRINE HUMAN PRESCRIPTION DRUG LABEL 1 42291-071 TABLET 50 mg ORAL ANDA 19 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 43353-745 TABLET 50 mg ORAL ANDA 23 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 51407-182 TABLET 50 mg ORAL ANDA 14 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 51407-182 TABLET 50 mg ORAL ANDA 14 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 51407-182 TABLET 50 mg ORAL ANDA 14 sections
IMURAN HUMAN PRESCRIPTION DRUG LABEL 1 54766-590 TABLET 50 mg ORAL NDA 23 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 54868-5310 TABLET 50 mg ORAL ANDA 20 sections
AZATHIOPRINE HUMAN PRESCRIPTION DRUG LABEL 1 60219-1076 TABLET 50 mg ORAL ANDA 19 sections
AZATHIOPRINE HUMAN PRESCRIPTION DRUG LABEL 1 60219-1076 TABLET 50 mg ORAL ANDA 19 sections
AZATHIOPRINE HUMAN PRESCRIPTION DRUG LABEL 1 60219-2036 TABLET 75 mg ORAL ANDA 19 sections
AZATHIOPRINE HUMAN PRESCRIPTION DRUG LABEL 1 60219-2036 TABLET 75 mg ORAL ANDA 19 sections
AZATHIOPRINE HUMAN PRESCRIPTION DRUG LABEL 1 60219-2037 TABLET 100 mg ORAL ANDA 19 sections
AZATHIOPRINE HUMAN PRESCRIPTION DRUG LABEL 1 60219-2037 TABLET 100 mg ORAL ANDA 19 sections
IMURAN HUMAN PRESCRIPTION DRUG LABEL 1 65483-590 TABLET 50 mg ORAL NDA 23 sections
Azasan HUMAN PRESCRIPTION DRUG LABEL 1 65649-231 TABLET 75 mg ORAL ANDA 13 sections
Azasan HUMAN PRESCRIPTION DRUG LABEL 1 65649-231 TABLET 75 mg ORAL ANDA 13 sections
Azasan HUMAN PRESCRIPTION DRUG LABEL 1 65649-241 TABLET 100 mg ORAL ANDA 13 sections
Azasan HUMAN PRESCRIPTION DRUG LABEL 1 65649-241 TABLET 100 mg ORAL ANDA 13 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 65841-602 TABLET 50 mg ORAL ANDA 1 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 65841-602 TABLET 50 mg ORAL ANDA 1 sections
Azathioprine Human Prescription Drug Label 1 67877-492 TABLET 25 mg ORAL ANDA 21 sections
Azathioprine Human Prescription Drug Label 1 67877-492 TABLET 25 mg ORAL ANDA 21 sections
Azathioprine Human Prescription Drug Label 1 67877-493 TABLET 50 mg ORAL ANDA 21 sections
Azathioprine Human Prescription Drug Label 1 67877-493 TABLET 50 mg ORAL ANDA 21 sections