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tegomil fumarate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 5854 | 1817769-42-8 |
Description:
| Molecule | Description |
|---|---|
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Synonyms:
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Riulvy, active substance tegomil fumarate, is a medicine used to treat multiple sclerosis, a disease in which the immune system (the body’s natural defences) attacks the protective insulation around nerves (myelin) in the brain and spinal cord, causing inflammation and damage to the nerves themselves. The mechanism by which tegomil fumarate exerts therapeutic effects in multiple sclerosis is not fully understood. Tegomil fumarate acts via the major active metabolite, monomethyl fumarate. Preclinical studies indicate that monomethyl fumarate pharmacodynamic responses appear to be primarily mediated through activation of the Nuclear factor (erythroid derived 2)-like 2 (Nrf2) transcriptional pathway. Dimethyl fumarate has been shown to up regulate Nrf2-dependent antioxidant genes in patients (e.g. NAD(P)H dehydrogenase, quinone 1; [NQO1]).
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Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| July 28, 2025 | EMA | Neuraxpharm Pharmaceuticals S.L. |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | L04AX10 | ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS IMMUNOSUPPRESSANTS IMMUNOSUPPRESSANTS Other immunosuppressants |
Related Drugs by ATC class:
L04AX Other immunosuppressants 8 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Relapsing remitting multiple sclerosis | indication | 24700007 | DOID:2377 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| CHEMBL5314544 | ChEMBL_ID |
| C5909085 | UMLSCUI |
| CHEBI:759245 | CHEBI |
| 12628 | INN_ID |
| 92042830 | PUBCHEM_CID |
| MXD6KMG2ZP | UNII |
| D13167 | KEGG_DRUG |
Pharmaceutical products:
None