thalidomide ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
2616 50-35-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • thalidomide
  • (+/-)-Thalidomide
  • thalomid
A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
  • Molecular weight: 258.23
  • Formula: C13H10N2O4
  • CLOGP: 0.53
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 1
  • TPSA: 83.55
  • ALOGS: -2
  • ROTB: 1

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.10 g O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.05 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 22.13 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution) 0.95 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 3.40 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.40 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 4.70 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
July 16, 1998 FDA CELGENE
Feb. 24, 2021 PMDA Fujimoto Pharmaceutical Corporation

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Disease progression 1536.37 14.74 832 26674 95034 50482584
Death 1339.08 14.74 1223 26283 324156 50253462
Plasma cell myeloma 769.97 14.74 364 27142 30958 50546660
Human chorionic gonadotropin increased 655.14 14.74 149 27357 1102 50576516
Neuropathy peripheral 626.22 14.74 475 27031 96282 50481336
Malignant neoplasm progression 286.64 14.74 261 27245 67863 50509755
Deep vein thrombosis 194.63 14.74 219 27287 73085 50504533
Osteonecrosis 194.42 14.74 132 27374 22385 50555233
Pneumonia 171.69 14.74 522 26984 377879 50199739
Renal failure 152.49 14.74 235 27271 106398 50471220
Hepatosplenic T-cell lymphoma 129.70 14.74 35 27471 553 50577065
Plasma cell myeloma recurrent 114.67 14.74 46 27460 2612 50575006
Sepsis 102.13 14.74 224 27282 132701 50444917
Plasmacytoma 95.08 14.74 39 27467 2346 50575272
Pregnancy test urine positive 94.78 14.74 16 27490 13 50577605
Plasma cell leukaemia 94.46 14.74 31 27475 984 50576634
Human chorionic gonadotropin positive 87.41 14.74 16 27490 30 50577588
Arthralgia 85.67 14.74 68 27438 438634 50138984
Human chorionic gonadotropin abnormal 78.04 14.74 14 27492 22 50577596
Pulmonary embolism 77.63 14.74 171 27335 101533 50476085
Unevaluable event 76.50 14.74 109 27397 45957 50531661
Polyneuropathy 74.75 14.74 58 27448 12073 50565545
Myelodysplastic syndrome 73.55 14.74 63 27443 15069 50562549
Pancytopenia 73.05 14.74 149 27357 83881 50493737
Complications of bone marrow transplant 72.03 14.74 21 27485 445 50577173
Maternal exposure during pregnancy 70.66 14.74 4 27502 159774 50417844
Headache 68.67 14.74 106 27400 506429 50071189
Varicella zoster virus infection 67.45 14.74 31 27475 2458 50575160
Acute myeloid leukaemia 65.72 14.74 59 27447 15015 50562603
Alopecia 63.31 14.74 27 27479 245020 50332598
Abdominal discomfort 62.32 14.74 24 27482 231617 50346001
Drug ineffective 62.23 14.74 233 27273 819100 49758518
Drug hypersensitivity 59.70 14.74 31 27475 250979 50326639
Drug interaction 54.82 14.74 20 27486 199601 50378017
Thrombocytopenia 53.71 14.74 172 27334 127501 50450117
Osteonecrosis of jaw 52.58 14.74 76 27430 32450 50545168
Thrombosis 50.88 14.74 101 27405 55732 50521886
Therapeutic product effect decreased 50.53 14.74 7 27499 136043 50441575
Haemoglobin decreased 50.46 14.74 168 27338 127048 50450570
Body dysmorphic disorder 50.22 14.74 14 27492 251 50577367
Infusion related reaction 50.04 14.74 15 27491 169542 50408076
Pain 49.67 14.74 156 27350 578747 49998871
Bone lesion 48.67 14.74 32 27474 5138 50572480
Hip fracture 48.50 14.74 65 27441 25866 50551752
Mesenteric abscess 48.26 14.74 11 27495 82 50577536
Refractory cytopenia with multilineage dysplasia 48.14 14.74 12 27494 136 50577482
Bone disorder 47.94 14.74 55 27451 18697 50558921
Cardiac disorder 46.93 14.74 84 27422 42895 50534723
Jaw operation 46.18 14.74 17 27489 763 50576855
Pregnancy test false positive 45.88 14.74 12 27494 167 50577451
Injection site pain 45.55 14.74 4 27502 111020 50466598
Glossodynia 45.22 14.74 5 27501 115564 50462054
Constipation 45.00 14.74 210 27296 185498 50392120
Large intestinal ulcer perforation 44.81 14.74 10 27496 67 50577551
Epstein-Barr viraemia 44.26 14.74 17 27489 859 50576759
Acute leukaemia 44.21 14.74 18 27488 1062 50576556
Growth failure 42.87 14.74 13 27493 317 50577301
Musculoskeletal stiffness 42.46 14.74 9 27497 128472 50449146
Platelet count decreased 41.71 14.74 135 27371 100591 50477027
Respiratory failure 41.24 14.74 126 27380 91055 50486563
Gastrointestinal fungal infection 41.08 14.74 12 27494 256 50577362
Hair follicle tumour benign 40.82 14.74 13 27493 374 50577244
Synovitis 40.28 14.74 9 27497 123856 50453762
Acute lymphocytic leukaemia 40.02 14.74 21 27485 2220 50575398
Rhesus antigen positive 39.30 14.74 10 27496 124 50577494
Hepatic enzyme increased 39.02 14.74 13 27493 137367 50440251
Pruritus 38.64 14.74 59 27447 283509 50294109
Posterior reversible encephalopathy syndrome 38.52 14.74 44 27462 14884 50562734
Nasal abscess 38.38 14.74 10 27496 137 50577481
Asthenia 37.04 14.74 298 27208 318744 50258874
Tooth extraction 36.59 14.74 34 27472 9041 50568577
Metastatic malignant melanoma 36.19 14.74 16 27490 1158 50576460
Joint ankylosis 35.67 14.74 14 27492 750 50576868
Adverse drug reaction 35.66 14.74 87 27419 55135 50522483
Morganella infection 35.56 14.74 13 27493 572 50577046
Endocarditis bacterial 35.32 14.74 13 27493 583 50577035
Pregnancy test positive 35.05 14.74 9 27497 116 50577502
Oedema peripheral 34.91 14.74 174 27332 157787 50419831
Sinus polyp 34.86 14.74 11 27495 307 50577311
Cerebrovascular accident 34.86 14.74 122 27384 94558 50483060
Graft versus host disease 34.80 14.74 28 27478 6138 50571480
Joint swelling 33.44 14.74 51 27455 245235 50332383
Condition aggravated 33.11 14.74 70 27436 296988 50280630
Cardiac failure congestive 33.05 14.74 111 27395 84271 50493347
Full blood count decreased 32.92 14.74 50 27456 22296 50555322
Overdose 32.92 14.74 7 27499 99720 50477898
Laboratory test abnormal 32.89 14.74 51 27455 23157 50554461
Actinomycosis 32.45 14.74 14 27492 955 50576663
Hypersensitivity 32.04 14.74 42 27464 215119 50362499
Arthropathy 31.32 14.74 24 27482 157882 50419736
Clostridium bacteraemia 31.27 14.74 9 27497 182 50577436
Hypoglossal nerve paresis 31.09 14.74 8 27498 104 50577514
Stem cell transplant 30.84 14.74 16 27490 1652 50575966
Anaemia 29.92 14.74 237 27269 252219 50325399
Pleural effusion 29.16 14.74 104 27402 81350 50496268
Peripheral sensory neuropathy 29.13 14.74 26 27480 6565 50571053
Mucosal inflammation 28.91 14.74 66 27440 40076 50537542
Encephalitis viral 28.62 14.74 15 27491 1582 50576036
Wound 28.35 14.74 11 27495 105783 50471835
Diverticular perforation 28.35 14.74 19 27487 3149 50574469
Pathological fracture 27.58 14.74 27 27479 7655 50569963
Weight increased 27.48 14.74 42 27464 201849 50375769
Therapy non-responder 27.39 14.74 75 27431 50947 50526671
Haematocrit decreased 26.86 14.74 59 27447 34917 50542701
Syncope 26.79 14.74 119 27387 102883 50474735
Cytomegalovirus infection reactivation 26.52 14.74 17 27489 2614 50575004
Discomfort 26.30 14.74 13 27493 108367 50469251
Malnutrition 26.11 14.74 34 27472 13155 50564463
Blood immunoglobulin M decreased 26.05 14.74 11 27495 712 50576906
Inappropriate schedule of product administration 25.95 14.74 4 27502 71827 50505791
Hypoaesthesia 25.88 14.74 137 27369 127120 50450498
Enterococcal sepsis 25.81 14.74 13 27493 1262 50576356
Blood immunoglobulin G decreased 25.56 14.74 15 27491 1970 50575648
Migraine 25.43 14.74 5 27501 75275 50502343
Swelling 25.27 14.74 44 27462 200828 50376790
Bone debridement 25.06 14.74 8 27498 232 50577386
Viraemia 24.85 14.74 12 27494 1063 50576555
Protein total increased 24.84 14.74 16 27490 2480 50575138
Exposure during pregnancy 24.49 14.74 18 27488 120997 50456621
Intentional product use issue 24.18 14.74 6 27500 76912 50500706
Anxiety 24.12 14.74 37 27469 177569 50400049
Blood albumin increased 24.03 14.74 11 27495 864 50576754
Squamous cell carcinoma of skin 24.03 14.74 21 27485 5157 50572461
Debridement 23.80 14.74 12 27494 1167 50576451
Metastases to central nervous system 23.77 14.74 30 27476 11252 50566366
Systemic lupus erythematosus 23.54 14.74 25 27481 140597 50437021
VIth nerve paresis 23.25 14.74 6 27500 79 50577539
Dehydration 23.17 14.74 152 27354 152297 50425321
Mucosal erosion 22.81 14.74 12 27494 1275 50576343
Lung infiltration 22.67 14.74 32 27474 13361 50564257
Immunoglobulins decreased 22.52 14.74 11 27495 999 50576619
Oral surgery 22.51 14.74 11 27495 1000 50576618
Splenomegaly 22.47 14.74 27 27479 9633 50567985
Nausea 22.31 14.74 261 27245 705137 49872481
Failure to thrive 22.18 14.74 22 27484 6336 50571282
Osteolysis 22.08 14.74 15 27491 2542 50575076
Chronic kidney disease 21.88 14.74 59 27447 39712 50537906
Blood luteinising hormone increased 21.77 14.74 6 27500 103 50577515
Paraesthesia 21.48 14.74 125 27381 120118 50457500
Spinal cord compression 21.27 14.74 17 27489 3692 50573926
Osteomyelitis 21.03 14.74 41 27465 22312 50555306
Hypercalcaemia 20.97 14.74 42 27464 23310 50554308
Herpes zoster 20.89 14.74 85 27421 70701 50506917
Endocarditis 20.33 14.74 19 27487 5088 50572530
Leukaemia 19.98 14.74 16 27490 3483 50574135
Infection reactivation 19.79 14.74 10 27496 977 50576641
Protein urine present 19.50 14.74 19 27487 5358 50572260
Stress 19.42 14.74 3 27503 53790 50523828
Monoclonal immunoglobulin present 19.38 14.74 9 27497 731 50576887
Staphylococcal bacteraemia 19.13 14.74 18 27488 4859 50572759
Febrile neutropenia 19.07 14.74 104 27402 97563 50480055
Pneumonia fungal 19.01 14.74 17 27489 4303 50573315
Jaw disorder 18.93 14.74 18 27488 4925 50572693
Neoplasm progression 18.88 14.74 46 27460 29111 50548507
Light chain analysis increased 18.79 14.74 10 27496 1088 50576530
Hodgkin's disease 18.76 14.74 9 27497 786 50576832
Graft versus host disease in gastrointestinal tract 18.68 14.74 14 27492 2767 50574851
Rectal adenocarcinoma 18.62 14.74 8 27498 540 50577078
Musculoskeletal pain 18.53 14.74 8 27498 72169 50505449
Hospitalisation 18.30 14.74 7 27499 67930 50509688
Decubitus ulcer 18.21 14.74 24 27482 9394 50568224
Fungal oesophagitis 18.16 14.74 8 27498 574 50577044
White blood cell count decreased 18.10 14.74 117 27389 116605 50461013
Diarrhoea 18.09 14.74 219 27287 588257 49989361
Septic shock 17.95 14.74 70 27436 57105 50520513
Flushing 17.90 14.74 7 27499 67008 50510610
Nasopharyngitis 17.89 14.74 50 27456 192877 50384741
Listeria sepsis 17.86 14.74 8 27498 597 50577021
Oral fungal infection 17.74 14.74 13 27493 2482 50575136
Large intestine perforation 17.52 14.74 21 27485 7473 50570145
Graft versus host disease in skin 17.46 14.74 13 27493 2543 50575075
Treatment failure 17.44 14.74 30 27476 137607 50440011
Blood albumin decreased 17.25 14.74 28 27478 13208 50564410
Blood immunoglobulin G increased 16.96 14.74 10 27496 1325 50576293
Cellulitis staphylococcal 16.96 14.74 8 27498 673 50576945
Amyloidosis 16.95 14.74 9 27497 974 50576644
Oral disorder 16.75 14.74 21 27485 7823 50569795
Haemophagocytic lymphohistiocytosis 16.69 14.74 22 27484 8611 50569007
Hyperbaric oxygen therapy 16.69 14.74 4 27502 38 50577580
Refractory anaemia with ringed sideroblasts 16.61 14.74 3 27503 5 50577613
Cardiac amyloidosis 16.42 14.74 8 27498 723 50576895
Electrocardiogram QT prolonged 16.40 14.74 4 27502 51882 50525736
Cardiopulmonary failure 16.30 14.74 14 27492 3359 50574259
Therapy partial responder 16.29 14.74 19 27487 6572 50571046
Growth retardation 16.17 14.74 9 27497 1069 50576549
BK virus infection 16.08 14.74 13 27493 2868 50574750
Endothelial dysfunction 16.07 14.74 5 27501 133 50577485
Mobility decreased 16.03 14.74 12 27494 79936 50497682
Neutropenia 15.93 14.74 136 27370 147829 50429789
Myalgia 15.83 14.74 27 27479 124292 50453326
Bradycardia 15.67 14.74 73 27433 64353 50513265
Cutaneous tuberculosis 15.44 14.74 5 27501 152 50577466
B precursor type acute leukaemia 15.44 14.74 5 27501 152 50577466
Maxillofacial operation 15.40 14.74 3 27503 9 50577609
Basal cell carcinoma 15.29 14.74 37 27469 23319 50554299
Anxiety disorder 15.27 14.74 14 27492 3659 50573959
Incorrect dose administered 14.79 14.74 4 27502 48410 50529208

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Disease progression 2023.91 14.30 1221 32683 80695 29459928
Death 1634.72 14.30 1967 31937 340117 29200506
Plasma cell myeloma 689.79 14.30 464 33440 36651 29503972
Neuropathy peripheral 624.17 14.30 570 33334 70457 29470166
Malignant neoplasm progression 345.43 14.30 424 33480 73435 29467188
Osteonecrosis 322.41 14.30 198 33706 13321 29527302
Deep vein thrombosis 293.59 14.30 345 33559 57054 29483569
Plasma cell myeloma recurrent 256.27 14.30 111 33793 3572 29537051
Plasmacytoma 188.68 14.30 86 33818 3129 29537494
Pneumonia 152.29 14.30 746 33158 319426 29221197
Bone disorder 143.70 14.30 87 33817 5696 29534927
Acute myeloid leukaemia 133.84 14.30 127 33777 16386 29524237
Pulmonary embolism 128.57 14.30 276 33628 76258 29464365
Tooth extraction 112.70 14.30 66 33838 4063 29536560
Drug interaction 112.37 14.30 43 33861 197342 29343281
Unevaluable event 88.81 14.30 138 33766 29713 29510910
Renal failure 85.26 14.30 314 33590 118285 29422338
Polyneuropathy 82.73 14.30 85 33819 12067 29528556
Squamous cell carcinoma of skin 80.76 14.30 75 33829 9411 29531212
Constipation 79.33 14.30 299 33605 113861 29426762
Completed suicide 77.74 14.30 7 33897 90239 29450384
Pregnancy of partner 72.56 14.30 23 33881 297 29540326
Plasma cell leukaemia 68.75 14.30 28 33876 769 29539854
Sepsis 64.89 14.30 329 33575 142353 29398270
Spinal cord compression 64.48 14.30 44 33860 3538 29537085
Overdose 64.11 14.30 8 33896 79811 29460812
Basal cell carcinoma 63.07 14.30 87 33817 16823 29523800
Myelodysplastic syndrome 55.35 14.30 84 33820 17710 29522913
Thrombosis 54.42 14.30 139 33765 42906 29497717
Leukaemia 52.97 14.30 40 33864 3770 29536853
Full blood count decreased 51.89 14.30 77 33827 15915 29524708
Osteomyelitis 51.83 14.30 71 33833 13638 29526985
Bone debridement 47.80 14.30 15 33889 187 29540436
Bone lesion 45.81 14.30 32 33872 2672 29537951
Debridement 45.18 14.30 21 33883 799 29539824
Pruritus 43.37 14.30 42 33862 116807 29423816
JC virus infection 43.20 14.30 27 33877 1870 29538753
Oedema peripheral 41.68 14.30 231 33673 103326 29437297
Off label use 41.35 14.30 191 33713 300609 29240014
Type 2 lepra reaction 40.86 14.30 13 33891 170 29540453
Progressive multifocal leukoencephalopathy 40.51 14.30 50 33854 8669 29531954
Acute leukaemia 39.99 14.30 21 33883 1043 29539580
Metastases to central nervous system 39.95 14.30 45 33859 7086 29533537
Stem cell transplant 39.59 14.30 26 33878 1961 29538662
Hypoaesthesia 39.54 14.30 143 33761 53324 29487299
Inappropriate schedule of product administration 39.52 14.30 3 33901 44469 29496154
Osteonecrosis of jaw 39.22 14.30 69 33835 16441 29524182
Hospitalisation 38.44 14.30 4 33900 45984 29494639
Adverse drug reaction 37.27 14.30 84 33820 23936 29516687
Pathological fracture 35.78 14.30 32 33872 3823 29536800
Neoplasm progression 35.73 14.30 71 33833 18541 29522082
Metastatic malignant melanoma 34.35 14.30 23 33881 1792 29538831
Bone sequestrum 34.18 14.30 15 33889 498 29540125
Sequestrectomy 34.08 14.30 12 33892 218 29540405
Pancytopenia 33.76 14.30 186 33718 82982 29457641
Metastasis 32.89 14.30 29 33875 3400 29537223
Jaw disorder 32.23 14.30 23 33881 1987 29538636
Asthenia 31.97 14.30 382 33522 214868 29325755
Rhabdomyolysis 31.71 14.30 15 33889 60793 29479830
Infusion related reaction 31.58 14.30 6 33898 43880 29496743
Headache 31.27 14.30 99 33805 173908 29366715
Therapy non-responder 31.26 14.30 92 33812 30819 29509804
Amyloidosis 30.01 14.30 22 33882 1982 29538641
Oral surgery 29.87 14.30 14 33890 543 29540080
Respiratory failure 28.59 14.30 200 33704 96931 29443692
Acute kidney injury 28.38 14.30 183 33721 265084 29275539
Blood creatine phosphokinase increased 28.32 14.30 6 33898 40638 29499985
Pain in jaw 28.10 14.30 49 33855 11592 29529031
Alanine aminotransferase increased 28.09 14.30 24 33880 70920 29469703
Blood pressure increased 27.98 14.30 26 33878 73777 29466846
Laboratory test abnormal 27.55 14.30 63 33841 18122 29522501
Drug ineffective 27.17 14.30 276 33628 362894 29177729
Hypoglycaemia 26.66 14.30 11 33893 48335 29492288
Failure to thrive 26.37 14.30 38 33866 7646 29532977
Cardiac failure congestive 26.36 14.30 164 33740 76417 29464206
Urticaria 26.25 14.30 15 33889 54645 29485978
Hypercalcaemia 26.10 14.30 50 33854 12709 29527914
Conjunctival irritation 25.40 14.30 8 33896 101 29540522
Osteolysis 25.30 14.30 18 33886 1547 29539076
Hip fracture 25.11 14.30 44 33860 10448 29530175
Cerebral toxoplasmosis 24.56 14.30 17 33887 1399 29539224
Insomnia 24.46 14.30 40 33864 88721 29451902
Peripheral sensory neuropathy 24.34 14.30 32 33872 5907 29534716
Diverticular perforation 24.26 14.30 23 33881 2961 29537662
Cardiac disorder 23.69 14.30 95 33809 37168 29503455
Paraesthesia 23.59 14.30 123 33781 53722 29486901
Diarrhoea 23.18 14.30 257 33647 332441 29208182
Enterococcal infection 22.88 14.30 37 33867 8231 29532392
Acute lymphocytic leukaemia 22.77 14.30 21 33883 2610 29538013
Intentional product misuse 22.41 14.30 6 33898 34655 29505968
Compression fracture 22.39 14.30 21 33883 2667 29537956
Varicella zoster virus infection 21.72 14.30 16 33888 1452 29539171
Genital erythema 21.56 14.30 8 33896 170 29540453
Blood bilirubin decreased 21.48 14.30 9 33895 266 29540357
Malignant neoplasm of unknown primary site 21.45 14.30 10 33894 383 29540240
Hyperviscosity syndrome 21.17 14.30 8 33896 179 29540444
Follicular mucinosis 21.04 14.30 5 33899 19 29540604
Arthralgia 20.72 14.30 86 33818 139531 29401092
Impaired healing 20.57 14.30 47 33857 13511 29527112
VIth nerve paralysis 20.48 14.30 12 33892 739 29539884
Jaw operation 20.46 14.30 8 33896 197 29540426
Laryngeal cancer metastatic 20.41 14.30 6 33898 59 29540564
Electrocardiogram QT prolonged 20.29 14.30 8 33896 36129 29504494
Infection 20.26 14.30 154 33750 76597 29464026
Hepatitis B 20.07 14.30 28 33876 5469 29535154
Aggression 19.74 14.30 8 33896 35533 29505090
Haemoglobin decreased 19.55 14.30 200 33704 108175 29432448
Wrong technique in product usage process 19.29 14.30 6 33898 31422 29509201
Lung infiltration 19.17 14.30 42 33862 11737 29528886
Suicidal ideation 18.98 14.30 8 33896 34708 29505915
Renal cell carcinoma 18.78 14.30 25 33879 4671 29535952
Flushing 18.78 14.30 5 33899 28987 29511636
Hepatic function abnormal 18.53 14.30 11 33893 39248 29501375
Genotoxicity 18.38 14.30 5 33899 36 29540587
Weight decreased 18.27 14.30 100 33804 150805 29389818
Hyponatraemia 18.15 14.30 31 33873 67602 29473021
Hypercapnic coma 18.15 14.30 7 33897 166 29540457
VIth nerve paresis 17.60 14.30 5 33899 43 29540580
Malaise 17.59 14.30 109 33795 159493 29381130
Incorrect dose administered 17.40 14.30 8 33896 32976 29507647
Anaphylactic reaction 17.40 14.30 5 33899 27568 29513055
Varicella 17.39 14.30 14 33890 1449 29539174
Abdominal pain 17.33 14.30 88 33816 135269 29405354
Aspartate aminotransferase increased 17.32 14.30 26 33878 59699 29480924
Agitation 17.26 14.30 20 33884 51284 29489339
Squamous cell carcinoma 17.20 14.30 37 33867 10214 29530409
Hallucination 16.65 14.30 16 33888 44696 29495927
Arachnoiditis 16.45 14.30 8 33896 337 29540286
Myalgia 16.36 14.30 38 33866 73981 29466642
Haematocrit decreased 16.11 14.30 71 33833 28951 29511672
Refractory cancer 16.02 14.30 6 33898 131 29540492
Neutropenic sepsis 15.99 14.30 39 33865 11688 29528935
Actinomycosis 15.76 14.30 8 33896 370 29540253
Acute generalised exanthematous pustulosis 15.47 14.30 25 33879 5558 29535065
Refractory anaemia with an excess of blasts 15.39 14.30 8 33896 389 29540234
Tachycardia 15.35 14.30 38 33866 72372 29468251
Bladder transitional cell carcinoma stage III 15.33 14.30 4 33900 24 29540599
Brain neoplasm malignant 15.33 14.30 9 33895 556 29540067
Hepatic enzyme increased 15.21 14.30 10 33894 33789 29506834
Rheumatoid arthritis 15.18 14.30 9 33895 32143 29508480
Metastatic neoplasm 15.10 14.30 17 33887 2675 29537948
Bone pain 15.05 14.30 51 33853 18401 29522222
Lymphocytic leukaemia 14.93 14.30 6 33898 159 29540464
Pallor 14.86 14.30 3 33901 21021 29519602
Brain cancer metastatic 14.85 14.30 5 33899 79 29540544
Malignant melanoma 14.57 14.30 28 33876 7133 29533490
Musculoskeletal stiffness 14.42 14.30 13 33891 37445 29503178
Cachexia 14.39 14.30 26 33878 6323 29534300

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Disease progression 3795.63 13.50 1929 46664 139751 64310388
Death 3162.87 13.50 2714 45879 479991 63970148
Plasma cell myeloma 1252.00 13.50 636 47957 45439 64404700
Neuropathy peripheral 827.27 13.50 694 47899 116831 64333308
Malignant neoplasm progression 782.97 13.50 661 47932 112210 64337929
Human chorionic gonadotropin increased 457.42 13.50 111 48482 775 64449364
Plasma cell myeloma recurrent 448.71 13.50 153 48440 3912 64446227
Deep vein thrombosis 443.95 13.50 468 48125 104714 64345425
Osteonecrosis 412.77 13.50 260 48333 27969 64422170
Pneumonia 301.17 13.50 1014 47579 558562 63891577
Plasmacytoma 263.62 13.50 102 48491 3768 64446371
Renal failure 230.67 13.50 456 48137 181232 64268907
Pulmonary embolism 204.93 13.50 383 48210 145973 64304166
Acute myeloid leukaemia 184.09 13.50 158 48435 27305 64422834
Unevaluable event 158.74 13.50 193 48400 50296 64399843
Sepsis 156.96 13.50 454 48139 229887 64220252
Plasma cell leukaemia 138.95 13.50 50 48543 1503 64448636
Polyneuropathy 136.47 13.50 116 48477 19778 64430361
Completed suicide 133.94 13.50 9 48584 224405 64225734
Drug interaction 128.61 13.50 56 48537 362027 64088112
Tooth extraction 126.82 13.50 83 48510 9518 64440621
Myelodysplastic syndrome 125.62 13.50 128 48465 27451 64422688
Squamous cell carcinoma of skin 115.37 13.50 85 48508 11791 64438348
Rheumatoid arthritis 109.77 13.50 3 48590 164291 64285848
Bone disorder 105.40 13.50 93 48500 16666 64433473
Headache 103.82 13.50 149 48444 529318 63920821
Drug hypersensitivity 103.23 13.50 26 48567 237789 64212350
Arthralgia 102.92 13.50 109 48484 442151 64007988
Pregnancy test urine positive 92.59 13.50 16 48577 8 64450131
Pancytopenia 89.43 13.50 274 48319 143035 64307104
Pruritus 87.02 13.50 65 48528 312335 64137804
Basal cell carcinoma 85.91 13.50 111 48482 30727 64419412
Acute leukaemia 84.16 13.50 35 48558 1563 64448576
Overdose 83.03 13.50 11 48582 159555 64290584
Leukaemia 82.27 13.50 50 48543 5038 64445101
Constipation 79.64 13.50 363 48230 228974 64221165
Metastases to central nervous system 77.27 13.50 72 48521 13840 64436299
Hepatosplenic T-cell lymphoma 75.55 13.50 27 48566 795 64449344
Metastatic malignant melanoma 74.50 13.50 37 48556 2504 64447635
Infusion related reaction 73.26 13.50 17 48576 164450 64285689
Varicella zoster virus infection 72.79 13.50 42 48551 3846 64446293
Human chorionic gonadotropin positive 72.36 13.50 14 48579 25 64450114
Injection site pain 71.01 13.50 3 48590 111405 64338734
Cardiac failure congestive 69.96 13.50 237 48356 130343 64319796
Complications of bone marrow transplant 66.56 13.50 23 48570 612 64449527
Stem cell transplant 66.23 13.50 38 48555 3443 64446696
Haemoglobin decreased 65.65 13.50 306 48287 194757 64255382
Thrombosis 64.02 13.50 155 48438 70487 64379652
Arthropathy 63.74 13.50 8 48585 120959 64329180
Bone debridement 62.11 13.50 20 48573 425 64449714
Oedema peripheral 60.84 13.50 316 48277 210001 64240138
Bone lesion 59.66 13.50 41 48552 5096 64445043
Drug ineffective 58.23 13.50 383 48210 839864 63610275
Alopecia 58.14 13.50 26 48567 165664 64284475
Full blood count decreased 57.82 13.50 78 48515 22504 64427635
Amyloidosis 57.79 13.50 31 48562 2463 64447676
Oral surgery 57.18 13.50 23 48570 942 64449197
Inappropriate schedule of product administration 57.14 13.50 3 48590 92283 64357856
Osteonecrosis of jaw 56.59 13.50 105 48488 39720 64410419
Respiratory failure 56.55 13.50 256 48337 160927 64289212
Thrombocytopenia 55.83 13.50 323 48270 223478 64226661
Jaw operation 55.25 13.50 21 48572 738 64449401
Malaise 54.31 13.50 138 48455 396109 64054030
Pain 54.19 13.50 224 48369 553287 63896852
Osteomyelitis 54.14 13.50 84 48509 27503 64422636
Weight increased 53.66 13.50 49 48544 213299 64236840
Therapeutic product effect decreased 53.23 13.50 11 48582 115340 64334799
Haematocrit decreased 52.85 13.50 123 48470 54532 64395607
Musculoskeletal stiffness 52.40 13.50 14 48579 123192 64326947
Joint swelling 52.37 13.50 51 48542 215331 64234808
Spinal cord compression 51.33 13.50 39 48554 5664 64444475
Acute lymphocytic leukaemia 51.03 13.50 35 48558 4336 64445803
Abdominal discomfort 50.63 13.50 38 48555 182284 64267855
Nasopharyngitis 50.54 13.50 44 48549 196029 64254110
Diverticular perforation 49.93 13.50 37 48556 5176 64444963
Hypersensitivity 49.54 13.50 45 48548 196407 64253732
Therapy non-responder 48.77 13.50 134 48459 65765 64384374
Human chorionic gonadotropin abnormal 47.69 13.50 9 48584 13 64450126
Asthenia 47.54 13.50 512 48081 427532 64022607
Synovitis 46.66 13.50 9 48584 99081 64351058
Debridement 45.68 13.50 23 48570 1603 64448536
Hepatic enzyme increased 44.63 13.50 21 48572 129922 64320217
Neoplasm progression 42.72 13.50 95 48498 40869 64409270
Peripheral sensory neuropathy 41.56 13.50 47 48546 11331 64438808
Large intestinal ulcer perforation 41.56 13.50 10 48583 67 64450072
Refractory cytopenia with multilineage dysplasia 41.21 13.50 13 48580 258 64449881
Mesenteric abscess 41.12 13.50 11 48582 118 64450021
Renal cell carcinoma 40.64 13.50 35 48558 6069 64444070
Anxiety 40.61 13.50 56 48537 202593 64247546
Type 2 lepra reaction 40.10 13.50 12 48581 198 64449941
VIth nerve paresis 40.07 13.50 11 48582 131 64450008
Pleural effusion 39.97 13.50 195 48398 126364 64323775
Hypercalcaemia 39.92 13.50 79 48514 31337 64418802
Platelet count decreased 39.18 13.50 238 48355 167473 64282666
Suicide attempt 39.15 13.50 4 48589 71003 64379136
Injection site erythema 39.00 13.50 4 48589 70796 64379343
Metastasis 38.62 13.50 33 48560 5662 64444477
Pregnancy of partner 38.04 13.50 12 48581 238 64449901
Urticaria 38.02 13.50 33 48560 147284 64302855
Actinomycosis 37.71 13.50 17 48576 925 64449214
Body dysmorphic disorder 37.63 13.50 12 48581 247 64449892
Blood pressure increased 37.34 13.50 45 48548 172507 64277632
Bone sequestrum 37.15 13.50 18 48575 1154 64448985
Rhesus antigen positive 36.06 13.50 10 48583 124 64450015
Migraine 35.97 13.50 3 48590 62674 64387465
Enterococcal infection 35.66 13.50 48 48545 13818 64436321
Hair follicle tumour benign 35.18 13.50 13 48580 422 64449717
Hospitalisation 35.05 13.50 7 48586 75200 64374939
Glossodynia 34.76 13.50 4 48589 64692 64385447
Lung infiltration 34.72 13.50 59 48534 20830 64429309
Failure to thrive 34.69 13.50 41 48552 10363 64439776
Stress 34.46 13.50 3 48590 60531 64389608
Nasal abscess 34.43 13.50 10 48583 148 64449991
Pathological fracture 34.27 13.50 38 48555 8967 64441172
Wound 33.85 13.50 8 48585 76469 64373670
Electrocardiogram QT prolonged 33.83 13.50 9 48584 79439 64370700
Progressive multifocal leukoencephalopathy 33.68 13.50 54 48539 18178 64431961
Insomnia 33.63 13.50 61 48532 197775 64252364
Pregnancy test false positive 33.44 13.50 9 48584 99 64450040
Hip fracture 33.06 13.50 67 48526 27032 64423107
Mucosal inflammation 32.96 13.50 113 48480 62471 64387668
Gastrointestinal fungal infection 32.87 13.50 12 48581 376 64449763
Exposure during pregnancy 32.70 13.50 9 48584 77666 64372473
Myalgia 32.61 13.50 43 48550 158574 64291565
Osteolysis 31.67 13.50 22 48571 2781 64447358
Flushing 31.49 13.50 10 48583 78638 64371501
Alanine aminotransferase increased 31.43 13.50 35 48558 138996 64311143
Laboratory test abnormal 31.16 13.50 61 48532 24002 64426137
Anaemia 31.10 13.50 428 48165 378252 64071887
Prothrombin time prolonged 30.98 13.50 48 48545 15693 64434446
Wrong technique in product usage process 30.38 13.50 6 48587 64968 64385171
Diarrhoea 30.32 13.50 374 48219 722330 63727809
Pregnancy test positive 30.23 13.50 8 48585 82 64450057
Chronic kidney disease 30.00 13.50 104 48489 57815 64392324
Rhabdomyolysis 29.73 13.50 16 48577 91710 64358429
Nausea 29.55 13.50 416 48177 785384 63664755
Rectal adenocarcinoma 29.19 13.50 16 48577 1327 64448812
Endocarditis bacterial 29.19 13.50 16 48577 1327 64448812
Staphylococcal bacteraemia 28.41 13.50 37 48556 10318 64439821
Angioedema 28.30 13.50 6 48587 61815 64388324
Hypoglossal nerve paresis 28.29 13.50 8 48585 107 64450032
JC virus infection 28.13 13.50 22 48571 3333 64446806
Condition aggravated 28.12 13.50 165 48428 372261 64077878
Oxygen saturation decreased 27.66 13.50 24 48569 107152 64342987
Sinus polyp 27.47 13.50 11 48582 445 64449694
Conjunctival irritation 26.97 13.50 8 48585 128 64450011
Malignant neoplasm of unknown primary site 26.27 13.50 12 48581 673 64449466
Jaw disorder 25.84 13.50 24 48569 4593 64445546
Incorrect dose administered 25.65 13.50 7 48586 60758 64389381
Therapy partial responder 25.63 13.50 35 48558 10213 64439926
Nocardiosis 25.18 13.50 24 48569 4743 64445396
Blood immunoglobulin M decreased 24.98 13.50 13 48580 971 64449168
Joint ankylosis 24.95 13.50 12 48581 757 64449382
Morganella infection 24.71 13.50 13 48580 993 64449146
Clostridium bacteraemia 24.68 13.50 9 48584 281 64449858
B precursor type acute leukaemia 24.42 13.50 9 48584 290 64449849
Blood albumin decreased 24.41 13.50 51 48542 21022 64429117
Intentional product misuse 24.33 13.50 12 48581 72283 64377856
Light chain analysis increased 24.14 13.50 14 48579 1294 64448845
Oropharyngeal pain 24.04 13.50 19 48574 88848 64361291
Blood pressure fluctuation 23.81 13.50 5 48588 51866 64398273
Syncope 23.60 13.50 201 48392 157434 64292705
Cardiopulmonary failure 23.41 13.50 26 48567 6144 64443995
Blood immunoglobulin G decreased 23.38 13.50 18 48575 2665 64447474
Hyperbaric oxygen therapy 23.38 13.50 6 48587 54 64450085
Hypoglycaemia 23.35 13.50 20 48573 89872 64360267
Infection 23.24 13.50 227 48366 184653 64265486
Pericarditis 23.22 13.50 9 48584 62507 64387632
Cardiac amyloidosis 23.12 13.50 14 48579 1401 64448738
Genital erythema 23.00 13.50 8 48585 217 64449922
Dehydration 22.93 13.50 257 48336 216506 64233633
Metastatic neoplasm 22.78 13.50 22 48571 4420 64445719
Hyperviscosity syndrome 22.72 13.50 9 48584 354 64449785
Follicular mucinosis 22.54 13.50 5 48588 22 64450117
Blood creatine phosphokinase increased 22.47 13.50 8 48585 58550 64391589
Acute generalised exanthematous pustulosis 22.44 13.50 39 48554 14019 64436120
Mobility decreased 22.42 13.50 19 48574 85821 64364318
Contusion 22.31 13.50 32 48561 113933 64336206
Clostridium colitis 22.14 13.50 17 48576 2508 64447631
Aspartate aminotransferase increased 22.13 13.50 35 48558 119753 64330386
Blood immunoglobulin G increased 22.10 13.50 15 48578 1826 64448313
Weight decreased 21.87 13.50 126 48467 285613 64164526
Hepatitis B 21.75 13.50 28 48565 7717 64442422
Abdominal pain 21.69 13.50 142 48451 312233 64137906
Posterior reversible encephalopathy syndrome 21.47 13.50 51 48542 22895 64427244
Cytomegalovirus infection reactivation 21.40 13.50 24 48569 5732 64444407
Chest discomfort 21.37 13.50 34 48559 116072 64334067
Monoclonal immunoglobulin present 20.98 13.50 11 48582 834 64449305
Sequestrectomy 20.93 13.50 11 48582 838 64449301
Abdominal pain upper 20.93 13.50 65 48528 174965 64275174
Cachexia 20.85 13.50 30 48563 9187 64440952
Off label use 20.67 13.50 344 48249 632462 63817677
Febrile neutropenia 20.53 13.50 224 48369 187433 64262706
Neutropenia 20.52 13.50 273 48320 239351 64210788
Intentional product use issue 20.48 13.50 25 48568 95339 64354800
Peripheral swelling 20.16 13.50 85 48508 209068 64241071
Large intestine perforation 20.16 13.50 35 48558 12569 64437570
Erythema 19.96 13.50 73 48520 186997 64263142
Septic shock 19.96 13.50 142 48451 105295 64344844
Nasal congestion 19.93 13.50 10 48583 59648 64390491
Blister 19.86 13.50 19 48574 80948 64369191
Gastrooesophageal reflux disease 19.83 13.50 20 48573 83123 64367016
Feeling hot 19.77 13.50 5 48588 45658 64404481
Hepatic function abnormal 19.72 13.50 12 48581 64301 64385838
Wheezing 19.66 13.50 19 48574 80560 64369579
Dental care 19.41 13.50 10 48583 731 64449408
Mucosal erosion 19.14 13.50 14 48579 1920 64448219
Laryngeal cancer metastatic 19.01 13.50 5 48588 50 64450089
Drug intolerance 19.00 13.50 75 48518 187917 64262222
White blood cell count decreased 18.96 13.50 192 48401 157645 64292494
Blood cholesterol increased 18.94 13.50 7 48586 50059 64400080
Refractory cancer 18.89 13.50 7 48586 229 64449910
Staphylococcal infection 18.88 13.50 82 48511 50596 64399543
Cellulitis staphylococcal 18.78 13.50 11 48582 1036 64449103
Cardiac disorder 18.32 13.50 87 48506 55729 64394410
Aggression 18.29 13.50 6 48587 46226 64403913
Hodgkin's disease 18.22 13.50 10 48583 831 64449308
Bacteraemia 18.22 13.50 53 48540 26858 64423281
Anaphylactic reaction 18.18 13.50 15 48578 68649 64381490
Refractory anaemia with an excess of blasts 18.17 13.50 10 48583 836 64449303
Prostate cancer metastatic 18.15 13.50 17 48576 3287 64446852
Hypoaesthesia 18.06 13.50 172 48421 138936 64311203
Encephalopathy 18.00 13.50 11 48582 58808 64391331
Arthritis 17.97 13.50 22 48571 83792 64366347
Graft versus host disease 17.87 13.50 35 48558 13778 64436361
Musculoskeletal pain 17.79 13.50 21 48572 81273 64368866
Injection site bruising 17.77 13.50 3 48590 36370 64413769
VIth nerve paralysis 17.73 13.50 12 48581 1454 64448685
Pain in extremity 17.57 13.50 145 48448 302940 64147199
Therapeutic product effect incomplete 17.49 13.50 32 48561 103450 64346689
Hypoxia 17.44 13.50 120 48473 88029 64362110
Dialysis 17.37 13.50 39 48554 16881 64433258
Paraesthesia 17.30 13.50 166 48427 134356 64315783
General physical condition abnormal 17.28 13.50 21 48572 5461 64444678
Systemic lupus erythematosus 17.03 13.50 20 48573 77592 64372547
Blood pressure systolic increased 16.96 13.50 8 48585 49445 64400694
Lactic acidosis 16.77 13.50 13 48580 61397 64388742
Bone trimming 16.73 13.50 4 48589 26 64450113
Endothelial dysfunction 16.62 13.50 6 48587 182 64449957
Hot flush 16.61 13.50 7 48586 46228 64403911
Duodenal ulcer perforation 16.60 13.50 3 48590 34622 64415517
Bladder transitional cell carcinoma stage III 16.60 13.50 4 48589 27 64450112
Discomfort 16.54 13.50 22 48571 80856 64369283
Intestinal perforation 16.51 13.50 36 48557 15277 64434862
Bence Jones protein urine present 16.50 13.50 3 48590 3 64450136
Compression fracture 16.48 13.50 21 48572 5731 64444408
Immunoglobulins decreased 16.45 13.50 11 48582 1307 64448832
Feeling abnormal 16.41 13.50 49 48544 133553 64316586
Infection reactivation 16.35 13.50 13 48580 2017 64448122
Cerebrovascular accident 16.34 13.50 167 48426 137416 64312723
Heart rate increased 16.25 13.50 31 48562 98644 64351495
Lung neoplasm malignant 16.24 13.50 44 48549 21404 64428735
Depression 16.15 13.50 77 48516 183214 64266925
Agitation 16.15 13.50 26 48567 88341 64361798
Blood albumin increased 16.06 13.50 11 48582 1360 64448779
Enterococcal sepsis 16.00 13.50 14 48579 2480 64447659
Protein total increased 15.95 13.50 16 48577 3365 64446774
Blood luteinising hormone increased 15.94 13.50 6 48587 205 64449934
Atelectasis 15.93 13.50 51 48542 27215 64422924
Accidental overdose 15.89 13.50 3 48590 33554 64416585
Oedema 15.79 13.50 121 48472 91814 64358325
Medication error 15.77 13.50 9 48584 49957 64400182
Hypercapnic coma 15.46 13.50 7 48586 385 64449754
Squamous cell carcinoma 15.41 13.50 33 48560 13836 64436303
Osteoarthritis 15.37 13.50 15 48578 63321 64386818
Bence Jones proteinuria 15.28 13.50 3 48590 6 64450133
Strongyloidiasis 15.28 13.50 15 48578 3075 64447064
Atrial fibrillation 15.09 13.50 196 48397 170893 64279246
Fibrous dysplasia of bone 14.97 13.50 3 48590 7 64450132
Diverticulitis 14.78 13.50 63 48530 38555 64411584
Loss of personal independence in daily activities 14.52 13.50 20 48573 72434 64377705
Prostate cancer 14.39 13.50 40 48553 19755 64430384
Pneumonia parainfluenzae viral 14.34 13.50 6 48587 272 64449867
Chloroma 14.23 13.50 8 48585 697 64449442
Irritability 14.13 13.50 5 48588 36741 64413398
Blood culture positive 14.12 13.50 23 48570 7845 64442294
Dyskinesia 14.09 13.50 6 48587 39382 64410757
Renal amyloidosis 14.06 13.50 5 48588 145 64449994
Procalcitonin increased 14.04 13.50 13 48580 2478 64447661
Light chain analysis 13.96 13.50 3 48590 11 64450128
Vomiting 13.87 13.50 313 48280 550804 63899335
Hyperhidrosis 13.82 13.50 48 48545 124872 64325267
Swelling 13.71 13.50 68 48525 160150 64289989
Peripheral sensorimotor neuropathy 13.63 13.50 13 48580 2572 64447567
Folliculitis 13.60 13.50 3 48590 30074 64420065

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L04AX02 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
IMMUNOSUPPRESSANTS
IMMUNOSUPPRESSANTS
Other immunosuppressants
FDA PE N0000008663 Decreased Immunologically Active Molecule Activity
MeSH PA D020533 Angiogenesis Inhibitors
MeSH PA D000900 Anti-Bacterial Agents
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000970 Antineoplastic Agents
MeSH PA D006131 Growth Inhibitors
MeSH PA D006133 Growth Substances
MeSH PA D007155 Immunologic Factors
MeSH PA D007166 Immunosuppressive Agents
MeSH PA D007917 Leprostatic Agents
MeSH PA D009676 Noxae
MeSH PA D013723 Teratogens
CHEBI has role CHEBI:35472 anti-inflammatory drugs
CHEBI has role CHEBI:35610 antineoplastic agents
CHEBI has role CHEBI:35623 anticonvulsants
CHEBI has role CHEBI:35705 immunosuppressive agents
CHEBI has role CHEBI:35717 hypnotics
CHEBI has role CHEBI:35816 leprostatic drugs
CHEBI has role CHEBI:48422 angiogenesis antagonist
CHEBI has role CHEBI:50905 teratogeno
CHEBI has role CHEBI:50919 antiemetico

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Crow-Fukase (POEMS) syndrome indication 79268002 DOID:14039
Multiple myeloma indication 109989006 DOID:9538
Erythema nodosum leprosum indication 240411003
Refractory upper gastrointestinal bleeding due to angiodysplasia off-label use 37372002
Pyoderma gangrenosum off-label use 74578003 DOID:8553
Discoid lupus erythematosus off-label use 200938002
Actinic prurigo off-label use 201015007
Graft-versus-host disease off-label use 234646005
Erosive oral lichen planus off-label use 238662007
Subacute cutaneous lupus erythematosus off-label use 239891002
Recurrent aphthous ulcer off-label use 398870000
Refractory upper gastrointestinal bleeding due to angiodysplasia off-label use 29731000119103
Refractory upper gastrointestinal bleeding due to angiodysplasia off-label use 1082711000119110
Prevention of Recurrent Aphthous Stomatitis off-label use
Orthostatic hypotension contraindication 28651003
Bradycardia contraindication 48867003
Epilepsy contraindication 84757009 DOID:1826
Deep venous thrombosis contraindication 128053003
Pulmonary thromboembolism contraindication 233935004
Pregnancy, function contraindication 289908002
Peripheral nerve disease contraindication 302226006
Neutropenic disorder contraindication 303011007 DOID:1227
Thromboembolic disorder contraindication 371039008
Breastfeeding (mother) contraindication 413712001




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.84 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Protein cereblon Cytosolic other MODULATOR EC50 6.39 SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE
Prostaglandin G/H synthase 1 Enzyme IC50 6.43 WOMBAT-PK
Tumor necrosis factor Cytokine IC50 8 WOMBAT-PK
Prostaglandin G/H synthase 2 Enzyme IC50 6.30 WOMBAT-PK
Prostaglandin G/H synthase 2 Enzyme IC50 6.30 CHEMBL
Cereblon isoform 4 Unclassified Ki 5.36 CHEMBL
Prostaglandin G/H synthase 1 Enzyme IC50 6.43 CHEMBL

External reference:

IDSource
4021134 VUID
N0000148588 NUI
D00754 KEGG_DRUG
4021134 VANDF
C0039736 UMLSCUI
CHEBI:9513 CHEBI
CHEMBL468 ChEMBL_ID
DB01041 DRUGBANK_ID
D013792 MESH_DESCRIPTOR_UI
5426 PUBCHEM_CID
7327 IUPHAR_LIGAND_ID
762 INN_ID
4Z8R6ORS6L UNII
10432 RXNORM
11845 MMSL
7488 MMSL
d04331 MMSL
005933 NDDF
404878004 SNOMEDCT_US
78702007 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Thalomid HUMAN PRESCRIPTION DRUG LABEL 1 59572-205 CAPSULE 50 mg ORAL NDA 30 sections
Thalomid HUMAN PRESCRIPTION DRUG LABEL 1 59572-205 CAPSULE 50 mg ORAL NDA 30 sections
Thalomid HUMAN PRESCRIPTION DRUG LABEL 1 59572-210 CAPSULE 100 mg ORAL NDA 30 sections
Thalomid HUMAN PRESCRIPTION DRUG LABEL 1 59572-210 CAPSULE 100 mg ORAL NDA 30 sections
Thalomid HUMAN PRESCRIPTION DRUG LABEL 1 59572-215 CAPSULE 150 mg ORAL NDA 30 sections
Thalomid HUMAN PRESCRIPTION DRUG LABEL 1 59572-215 CAPSULE 150 mg ORAL NDA 30 sections
Thalomid HUMAN PRESCRIPTION DRUG LABEL 1 59572-220 CAPSULE 200 mg ORAL NDA 30 sections
Thalomid HUMAN PRESCRIPTION DRUG LABEL 1 59572-220 CAPSULE 200 mg ORAL NDA 30 sections