thalidomide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 2616 | 50-35-1 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 0.10 | g | O |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Benet LZ, Broccatelli F, Oprea TI |
| S (Water solubility) | 0.05 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
| EoM (Fraction excreted unchanged in urine) | 0.50 % | Benet LZ, Broccatelli F, Oprea TI |
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 22.13 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
| Vd (Volume of distribution) | 0.95 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 3.40 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| fu (Fraction unbound in plasma) | 0.40 % | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 4.70 hours | Lombardo F, Berellini G, Obach RS |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| July 16, 1998 | FDA | CELGENE | |
| Feb. 24, 2021 | PMDA | Fujimoto Pharmaceutical Corporation |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Disease progression | 1536.37 | 14.74 | 832 | 26674 | 95034 | 50482584 |
| Death | 1339.08 | 14.74 | 1223 | 26283 | 324156 | 50253462 |
| Plasma cell myeloma | 769.97 | 14.74 | 364 | 27142 | 30958 | 50546660 |
| Human chorionic gonadotropin increased | 655.14 | 14.74 | 149 | 27357 | 1102 | 50576516 |
| Neuropathy peripheral | 626.22 | 14.74 | 475 | 27031 | 96282 | 50481336 |
| Malignant neoplasm progression | 286.64 | 14.74 | 261 | 27245 | 67863 | 50509755 |
| Deep vein thrombosis | 194.63 | 14.74 | 219 | 27287 | 73085 | 50504533 |
| Osteonecrosis | 194.42 | 14.74 | 132 | 27374 | 22385 | 50555233 |
| Pneumonia | 171.69 | 14.74 | 522 | 26984 | 377879 | 50199739 |
| Renal failure | 152.49 | 14.74 | 235 | 27271 | 106398 | 50471220 |
| Hepatosplenic T-cell lymphoma | 129.70 | 14.74 | 35 | 27471 | 553 | 50577065 |
| Plasma cell myeloma recurrent | 114.67 | 14.74 | 46 | 27460 | 2612 | 50575006 |
| Sepsis | 102.13 | 14.74 | 224 | 27282 | 132701 | 50444917 |
| Plasmacytoma | 95.08 | 14.74 | 39 | 27467 | 2346 | 50575272 |
| Pregnancy test urine positive | 94.78 | 14.74 | 16 | 27490 | 13 | 50577605 |
| Plasma cell leukaemia | 94.46 | 14.74 | 31 | 27475 | 984 | 50576634 |
| Human chorionic gonadotropin positive | 87.41 | 14.74 | 16 | 27490 | 30 | 50577588 |
| Arthralgia | 85.67 | 14.74 | 68 | 27438 | 438634 | 50138984 |
| Human chorionic gonadotropin abnormal | 78.04 | 14.74 | 14 | 27492 | 22 | 50577596 |
| Pulmonary embolism | 77.63 | 14.74 | 171 | 27335 | 101533 | 50476085 |
| Unevaluable event | 76.50 | 14.74 | 109 | 27397 | 45957 | 50531661 |
| Polyneuropathy | 74.75 | 14.74 | 58 | 27448 | 12073 | 50565545 |
| Myelodysplastic syndrome | 73.55 | 14.74 | 63 | 27443 | 15069 | 50562549 |
| Pancytopenia | 73.05 | 14.74 | 149 | 27357 | 83881 | 50493737 |
| Complications of bone marrow transplant | 72.03 | 14.74 | 21 | 27485 | 445 | 50577173 |
| Maternal exposure during pregnancy | 70.66 | 14.74 | 4 | 27502 | 159774 | 50417844 |
| Headache | 68.67 | 14.74 | 106 | 27400 | 506429 | 50071189 |
| Varicella zoster virus infection | 67.45 | 14.74 | 31 | 27475 | 2458 | 50575160 |
| Acute myeloid leukaemia | 65.72 | 14.74 | 59 | 27447 | 15015 | 50562603 |
| Alopecia | 63.31 | 14.74 | 27 | 27479 | 245020 | 50332598 |
| Abdominal discomfort | 62.32 | 14.74 | 24 | 27482 | 231617 | 50346001 |
| Drug ineffective | 62.23 | 14.74 | 233 | 27273 | 819100 | 49758518 |
| Drug hypersensitivity | 59.70 | 14.74 | 31 | 27475 | 250979 | 50326639 |
| Drug interaction | 54.82 | 14.74 | 20 | 27486 | 199601 | 50378017 |
| Thrombocytopenia | 53.71 | 14.74 | 172 | 27334 | 127501 | 50450117 |
| Osteonecrosis of jaw | 52.58 | 14.74 | 76 | 27430 | 32450 | 50545168 |
| Thrombosis | 50.88 | 14.74 | 101 | 27405 | 55732 | 50521886 |
| Therapeutic product effect decreased | 50.53 | 14.74 | 7 | 27499 | 136043 | 50441575 |
| Haemoglobin decreased | 50.46 | 14.74 | 168 | 27338 | 127048 | 50450570 |
| Body dysmorphic disorder | 50.22 | 14.74 | 14 | 27492 | 251 | 50577367 |
| Infusion related reaction | 50.04 | 14.74 | 15 | 27491 | 169542 | 50408076 |
| Pain | 49.67 | 14.74 | 156 | 27350 | 578747 | 49998871 |
| Bone lesion | 48.67 | 14.74 | 32 | 27474 | 5138 | 50572480 |
| Hip fracture | 48.50 | 14.74 | 65 | 27441 | 25866 | 50551752 |
| Mesenteric abscess | 48.26 | 14.74 | 11 | 27495 | 82 | 50577536 |
| Refractory cytopenia with multilineage dysplasia | 48.14 | 14.74 | 12 | 27494 | 136 | 50577482 |
| Bone disorder | 47.94 | 14.74 | 55 | 27451 | 18697 | 50558921 |
| Cardiac disorder | 46.93 | 14.74 | 84 | 27422 | 42895 | 50534723 |
| Jaw operation | 46.18 | 14.74 | 17 | 27489 | 763 | 50576855 |
| Pregnancy test false positive | 45.88 | 14.74 | 12 | 27494 | 167 | 50577451 |
| Injection site pain | 45.55 | 14.74 | 4 | 27502 | 111020 | 50466598 |
| Glossodynia | 45.22 | 14.74 | 5 | 27501 | 115564 | 50462054 |
| Constipation | 45.00 | 14.74 | 210 | 27296 | 185498 | 50392120 |
| Large intestinal ulcer perforation | 44.81 | 14.74 | 10 | 27496 | 67 | 50577551 |
| Epstein-Barr viraemia | 44.26 | 14.74 | 17 | 27489 | 859 | 50576759 |
| Acute leukaemia | 44.21 | 14.74 | 18 | 27488 | 1062 | 50576556 |
| Growth failure | 42.87 | 14.74 | 13 | 27493 | 317 | 50577301 |
| Musculoskeletal stiffness | 42.46 | 14.74 | 9 | 27497 | 128472 | 50449146 |
| Platelet count decreased | 41.71 | 14.74 | 135 | 27371 | 100591 | 50477027 |
| Respiratory failure | 41.24 | 14.74 | 126 | 27380 | 91055 | 50486563 |
| Gastrointestinal fungal infection | 41.08 | 14.74 | 12 | 27494 | 256 | 50577362 |
| Hair follicle tumour benign | 40.82 | 14.74 | 13 | 27493 | 374 | 50577244 |
| Synovitis | 40.28 | 14.74 | 9 | 27497 | 123856 | 50453762 |
| Acute lymphocytic leukaemia | 40.02 | 14.74 | 21 | 27485 | 2220 | 50575398 |
| Rhesus antigen positive | 39.30 | 14.74 | 10 | 27496 | 124 | 50577494 |
| Hepatic enzyme increased | 39.02 | 14.74 | 13 | 27493 | 137367 | 50440251 |
| Pruritus | 38.64 | 14.74 | 59 | 27447 | 283509 | 50294109 |
| Posterior reversible encephalopathy syndrome | 38.52 | 14.74 | 44 | 27462 | 14884 | 50562734 |
| Nasal abscess | 38.38 | 14.74 | 10 | 27496 | 137 | 50577481 |
| Asthenia | 37.04 | 14.74 | 298 | 27208 | 318744 | 50258874 |
| Tooth extraction | 36.59 | 14.74 | 34 | 27472 | 9041 | 50568577 |
| Metastatic malignant melanoma | 36.19 | 14.74 | 16 | 27490 | 1158 | 50576460 |
| Joint ankylosis | 35.67 | 14.74 | 14 | 27492 | 750 | 50576868 |
| Adverse drug reaction | 35.66 | 14.74 | 87 | 27419 | 55135 | 50522483 |
| Morganella infection | 35.56 | 14.74 | 13 | 27493 | 572 | 50577046 |
| Endocarditis bacterial | 35.32 | 14.74 | 13 | 27493 | 583 | 50577035 |
| Pregnancy test positive | 35.05 | 14.74 | 9 | 27497 | 116 | 50577502 |
| Oedema peripheral | 34.91 | 14.74 | 174 | 27332 | 157787 | 50419831 |
| Sinus polyp | 34.86 | 14.74 | 11 | 27495 | 307 | 50577311 |
| Cerebrovascular accident | 34.86 | 14.74 | 122 | 27384 | 94558 | 50483060 |
| Graft versus host disease | 34.80 | 14.74 | 28 | 27478 | 6138 | 50571480 |
| Joint swelling | 33.44 | 14.74 | 51 | 27455 | 245235 | 50332383 |
| Condition aggravated | 33.11 | 14.74 | 70 | 27436 | 296988 | 50280630 |
| Cardiac failure congestive | 33.05 | 14.74 | 111 | 27395 | 84271 | 50493347 |
| Full blood count decreased | 32.92 | 14.74 | 50 | 27456 | 22296 | 50555322 |
| Overdose | 32.92 | 14.74 | 7 | 27499 | 99720 | 50477898 |
| Laboratory test abnormal | 32.89 | 14.74 | 51 | 27455 | 23157 | 50554461 |
| Actinomycosis | 32.45 | 14.74 | 14 | 27492 | 955 | 50576663 |
| Hypersensitivity | 32.04 | 14.74 | 42 | 27464 | 215119 | 50362499 |
| Arthropathy | 31.32 | 14.74 | 24 | 27482 | 157882 | 50419736 |
| Clostridium bacteraemia | 31.27 | 14.74 | 9 | 27497 | 182 | 50577436 |
| Hypoglossal nerve paresis | 31.09 | 14.74 | 8 | 27498 | 104 | 50577514 |
| Stem cell transplant | 30.84 | 14.74 | 16 | 27490 | 1652 | 50575966 |
| Anaemia | 29.92 | 14.74 | 237 | 27269 | 252219 | 50325399 |
| Pleural effusion | 29.16 | 14.74 | 104 | 27402 | 81350 | 50496268 |
| Peripheral sensory neuropathy | 29.13 | 14.74 | 26 | 27480 | 6565 | 50571053 |
| Mucosal inflammation | 28.91 | 14.74 | 66 | 27440 | 40076 | 50537542 |
| Encephalitis viral | 28.62 | 14.74 | 15 | 27491 | 1582 | 50576036 |
| Wound | 28.35 | 14.74 | 11 | 27495 | 105783 | 50471835 |
| Diverticular perforation | 28.35 | 14.74 | 19 | 27487 | 3149 | 50574469 |
| Pathological fracture | 27.58 | 14.74 | 27 | 27479 | 7655 | 50569963 |
| Weight increased | 27.48 | 14.74 | 42 | 27464 | 201849 | 50375769 |
| Therapy non-responder | 27.39 | 14.74 | 75 | 27431 | 50947 | 50526671 |
| Haematocrit decreased | 26.86 | 14.74 | 59 | 27447 | 34917 | 50542701 |
| Syncope | 26.79 | 14.74 | 119 | 27387 | 102883 | 50474735 |
| Cytomegalovirus infection reactivation | 26.52 | 14.74 | 17 | 27489 | 2614 | 50575004 |
| Discomfort | 26.30 | 14.74 | 13 | 27493 | 108367 | 50469251 |
| Malnutrition | 26.11 | 14.74 | 34 | 27472 | 13155 | 50564463 |
| Blood immunoglobulin M decreased | 26.05 | 14.74 | 11 | 27495 | 712 | 50576906 |
| Inappropriate schedule of product administration | 25.95 | 14.74 | 4 | 27502 | 71827 | 50505791 |
| Hypoaesthesia | 25.88 | 14.74 | 137 | 27369 | 127120 | 50450498 |
| Enterococcal sepsis | 25.81 | 14.74 | 13 | 27493 | 1262 | 50576356 |
| Blood immunoglobulin G decreased | 25.56 | 14.74 | 15 | 27491 | 1970 | 50575648 |
| Migraine | 25.43 | 14.74 | 5 | 27501 | 75275 | 50502343 |
| Swelling | 25.27 | 14.74 | 44 | 27462 | 200828 | 50376790 |
| Bone debridement | 25.06 | 14.74 | 8 | 27498 | 232 | 50577386 |
| Viraemia | 24.85 | 14.74 | 12 | 27494 | 1063 | 50576555 |
| Protein total increased | 24.84 | 14.74 | 16 | 27490 | 2480 | 50575138 |
| Exposure during pregnancy | 24.49 | 14.74 | 18 | 27488 | 120997 | 50456621 |
| Intentional product use issue | 24.18 | 14.74 | 6 | 27500 | 76912 | 50500706 |
| Anxiety | 24.12 | 14.74 | 37 | 27469 | 177569 | 50400049 |
| Blood albumin increased | 24.03 | 14.74 | 11 | 27495 | 864 | 50576754 |
| Squamous cell carcinoma of skin | 24.03 | 14.74 | 21 | 27485 | 5157 | 50572461 |
| Debridement | 23.80 | 14.74 | 12 | 27494 | 1167 | 50576451 |
| Metastases to central nervous system | 23.77 | 14.74 | 30 | 27476 | 11252 | 50566366 |
| Systemic lupus erythematosus | 23.54 | 14.74 | 25 | 27481 | 140597 | 50437021 |
| VIth nerve paresis | 23.25 | 14.74 | 6 | 27500 | 79 | 50577539 |
| Dehydration | 23.17 | 14.74 | 152 | 27354 | 152297 | 50425321 |
| Mucosal erosion | 22.81 | 14.74 | 12 | 27494 | 1275 | 50576343 |
| Lung infiltration | 22.67 | 14.74 | 32 | 27474 | 13361 | 50564257 |
| Immunoglobulins decreased | 22.52 | 14.74 | 11 | 27495 | 999 | 50576619 |
| Oral surgery | 22.51 | 14.74 | 11 | 27495 | 1000 | 50576618 |
| Splenomegaly | 22.47 | 14.74 | 27 | 27479 | 9633 | 50567985 |
| Nausea | 22.31 | 14.74 | 261 | 27245 | 705137 | 49872481 |
| Failure to thrive | 22.18 | 14.74 | 22 | 27484 | 6336 | 50571282 |
| Osteolysis | 22.08 | 14.74 | 15 | 27491 | 2542 | 50575076 |
| Chronic kidney disease | 21.88 | 14.74 | 59 | 27447 | 39712 | 50537906 |
| Blood luteinising hormone increased | 21.77 | 14.74 | 6 | 27500 | 103 | 50577515 |
| Paraesthesia | 21.48 | 14.74 | 125 | 27381 | 120118 | 50457500 |
| Spinal cord compression | 21.27 | 14.74 | 17 | 27489 | 3692 | 50573926 |
| Osteomyelitis | 21.03 | 14.74 | 41 | 27465 | 22312 | 50555306 |
| Hypercalcaemia | 20.97 | 14.74 | 42 | 27464 | 23310 | 50554308 |
| Herpes zoster | 20.89 | 14.74 | 85 | 27421 | 70701 | 50506917 |
| Endocarditis | 20.33 | 14.74 | 19 | 27487 | 5088 | 50572530 |
| Leukaemia | 19.98 | 14.74 | 16 | 27490 | 3483 | 50574135 |
| Infection reactivation | 19.79 | 14.74 | 10 | 27496 | 977 | 50576641 |
| Protein urine present | 19.50 | 14.74 | 19 | 27487 | 5358 | 50572260 |
| Stress | 19.42 | 14.74 | 3 | 27503 | 53790 | 50523828 |
| Monoclonal immunoglobulin present | 19.38 | 14.74 | 9 | 27497 | 731 | 50576887 |
| Staphylococcal bacteraemia | 19.13 | 14.74 | 18 | 27488 | 4859 | 50572759 |
| Febrile neutropenia | 19.07 | 14.74 | 104 | 27402 | 97563 | 50480055 |
| Pneumonia fungal | 19.01 | 14.74 | 17 | 27489 | 4303 | 50573315 |
| Jaw disorder | 18.93 | 14.74 | 18 | 27488 | 4925 | 50572693 |
| Neoplasm progression | 18.88 | 14.74 | 46 | 27460 | 29111 | 50548507 |
| Light chain analysis increased | 18.79 | 14.74 | 10 | 27496 | 1088 | 50576530 |
| Hodgkin's disease | 18.76 | 14.74 | 9 | 27497 | 786 | 50576832 |
| Graft versus host disease in gastrointestinal tract | 18.68 | 14.74 | 14 | 27492 | 2767 | 50574851 |
| Rectal adenocarcinoma | 18.62 | 14.74 | 8 | 27498 | 540 | 50577078 |
| Musculoskeletal pain | 18.53 | 14.74 | 8 | 27498 | 72169 | 50505449 |
| Hospitalisation | 18.30 | 14.74 | 7 | 27499 | 67930 | 50509688 |
| Decubitus ulcer | 18.21 | 14.74 | 24 | 27482 | 9394 | 50568224 |
| Fungal oesophagitis | 18.16 | 14.74 | 8 | 27498 | 574 | 50577044 |
| White blood cell count decreased | 18.10 | 14.74 | 117 | 27389 | 116605 | 50461013 |
| Diarrhoea | 18.09 | 14.74 | 219 | 27287 | 588257 | 49989361 |
| Septic shock | 17.95 | 14.74 | 70 | 27436 | 57105 | 50520513 |
| Flushing | 17.90 | 14.74 | 7 | 27499 | 67008 | 50510610 |
| Nasopharyngitis | 17.89 | 14.74 | 50 | 27456 | 192877 | 50384741 |
| Listeria sepsis | 17.86 | 14.74 | 8 | 27498 | 597 | 50577021 |
| Oral fungal infection | 17.74 | 14.74 | 13 | 27493 | 2482 | 50575136 |
| Large intestine perforation | 17.52 | 14.74 | 21 | 27485 | 7473 | 50570145 |
| Graft versus host disease in skin | 17.46 | 14.74 | 13 | 27493 | 2543 | 50575075 |
| Treatment failure | 17.44 | 14.74 | 30 | 27476 | 137607 | 50440011 |
| Blood albumin decreased | 17.25 | 14.74 | 28 | 27478 | 13208 | 50564410 |
| Blood immunoglobulin G increased | 16.96 | 14.74 | 10 | 27496 | 1325 | 50576293 |
| Cellulitis staphylococcal | 16.96 | 14.74 | 8 | 27498 | 673 | 50576945 |
| Amyloidosis | 16.95 | 14.74 | 9 | 27497 | 974 | 50576644 |
| Oral disorder | 16.75 | 14.74 | 21 | 27485 | 7823 | 50569795 |
| Haemophagocytic lymphohistiocytosis | 16.69 | 14.74 | 22 | 27484 | 8611 | 50569007 |
| Hyperbaric oxygen therapy | 16.69 | 14.74 | 4 | 27502 | 38 | 50577580 |
| Refractory anaemia with ringed sideroblasts | 16.61 | 14.74 | 3 | 27503 | 5 | 50577613 |
| Cardiac amyloidosis | 16.42 | 14.74 | 8 | 27498 | 723 | 50576895 |
| Electrocardiogram QT prolonged | 16.40 | 14.74 | 4 | 27502 | 51882 | 50525736 |
| Cardiopulmonary failure | 16.30 | 14.74 | 14 | 27492 | 3359 | 50574259 |
| Therapy partial responder | 16.29 | 14.74 | 19 | 27487 | 6572 | 50571046 |
| Growth retardation | 16.17 | 14.74 | 9 | 27497 | 1069 | 50576549 |
| BK virus infection | 16.08 | 14.74 | 13 | 27493 | 2868 | 50574750 |
| Endothelial dysfunction | 16.07 | 14.74 | 5 | 27501 | 133 | 50577485 |
| Mobility decreased | 16.03 | 14.74 | 12 | 27494 | 79936 | 50497682 |
| Neutropenia | 15.93 | 14.74 | 136 | 27370 | 147829 | 50429789 |
| Myalgia | 15.83 | 14.74 | 27 | 27479 | 124292 | 50453326 |
| Bradycardia | 15.67 | 14.74 | 73 | 27433 | 64353 | 50513265 |
| Cutaneous tuberculosis | 15.44 | 14.74 | 5 | 27501 | 152 | 50577466 |
| B precursor type acute leukaemia | 15.44 | 14.74 | 5 | 27501 | 152 | 50577466 |
| Maxillofacial operation | 15.40 | 14.74 | 3 | 27503 | 9 | 50577609 |
| Basal cell carcinoma | 15.29 | 14.74 | 37 | 27469 | 23319 | 50554299 |
| Anxiety disorder | 15.27 | 14.74 | 14 | 27492 | 3659 | 50573959 |
| Incorrect dose administered | 14.79 | 14.74 | 4 | 27502 | 48410 | 50529208 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Disease progression | 2023.91 | 14.30 | 1221 | 32683 | 80695 | 29459928 |
| Death | 1634.72 | 14.30 | 1967 | 31937 | 340117 | 29200506 |
| Plasma cell myeloma | 689.79 | 14.30 | 464 | 33440 | 36651 | 29503972 |
| Neuropathy peripheral | 624.17 | 14.30 | 570 | 33334 | 70457 | 29470166 |
| Malignant neoplasm progression | 345.43 | 14.30 | 424 | 33480 | 73435 | 29467188 |
| Osteonecrosis | 322.41 | 14.30 | 198 | 33706 | 13321 | 29527302 |
| Deep vein thrombosis | 293.59 | 14.30 | 345 | 33559 | 57054 | 29483569 |
| Plasma cell myeloma recurrent | 256.27 | 14.30 | 111 | 33793 | 3572 | 29537051 |
| Plasmacytoma | 188.68 | 14.30 | 86 | 33818 | 3129 | 29537494 |
| Pneumonia | 152.29 | 14.30 | 746 | 33158 | 319426 | 29221197 |
| Bone disorder | 143.70 | 14.30 | 87 | 33817 | 5696 | 29534927 |
| Acute myeloid leukaemia | 133.84 | 14.30 | 127 | 33777 | 16386 | 29524237 |
| Pulmonary embolism | 128.57 | 14.30 | 276 | 33628 | 76258 | 29464365 |
| Tooth extraction | 112.70 | 14.30 | 66 | 33838 | 4063 | 29536560 |
| Drug interaction | 112.37 | 14.30 | 43 | 33861 | 197342 | 29343281 |
| Unevaluable event | 88.81 | 14.30 | 138 | 33766 | 29713 | 29510910 |
| Renal failure | 85.26 | 14.30 | 314 | 33590 | 118285 | 29422338 |
| Polyneuropathy | 82.73 | 14.30 | 85 | 33819 | 12067 | 29528556 |
| Squamous cell carcinoma of skin | 80.76 | 14.30 | 75 | 33829 | 9411 | 29531212 |
| Constipation | 79.33 | 14.30 | 299 | 33605 | 113861 | 29426762 |
| Completed suicide | 77.74 | 14.30 | 7 | 33897 | 90239 | 29450384 |
| Pregnancy of partner | 72.56 | 14.30 | 23 | 33881 | 297 | 29540326 |
| Plasma cell leukaemia | 68.75 | 14.30 | 28 | 33876 | 769 | 29539854 |
| Sepsis | 64.89 | 14.30 | 329 | 33575 | 142353 | 29398270 |
| Spinal cord compression | 64.48 | 14.30 | 44 | 33860 | 3538 | 29537085 |
| Overdose | 64.11 | 14.30 | 8 | 33896 | 79811 | 29460812 |
| Basal cell carcinoma | 63.07 | 14.30 | 87 | 33817 | 16823 | 29523800 |
| Myelodysplastic syndrome | 55.35 | 14.30 | 84 | 33820 | 17710 | 29522913 |
| Thrombosis | 54.42 | 14.30 | 139 | 33765 | 42906 | 29497717 |
| Leukaemia | 52.97 | 14.30 | 40 | 33864 | 3770 | 29536853 |
| Full blood count decreased | 51.89 | 14.30 | 77 | 33827 | 15915 | 29524708 |
| Osteomyelitis | 51.83 | 14.30 | 71 | 33833 | 13638 | 29526985 |
| Bone debridement | 47.80 | 14.30 | 15 | 33889 | 187 | 29540436 |
| Bone lesion | 45.81 | 14.30 | 32 | 33872 | 2672 | 29537951 |
| Debridement | 45.18 | 14.30 | 21 | 33883 | 799 | 29539824 |
| Pruritus | 43.37 | 14.30 | 42 | 33862 | 116807 | 29423816 |
| JC virus infection | 43.20 | 14.30 | 27 | 33877 | 1870 | 29538753 |
| Oedema peripheral | 41.68 | 14.30 | 231 | 33673 | 103326 | 29437297 |
| Off label use | 41.35 | 14.30 | 191 | 33713 | 300609 | 29240014 |
| Type 2 lepra reaction | 40.86 | 14.30 | 13 | 33891 | 170 | 29540453 |
| Progressive multifocal leukoencephalopathy | 40.51 | 14.30 | 50 | 33854 | 8669 | 29531954 |
| Acute leukaemia | 39.99 | 14.30 | 21 | 33883 | 1043 | 29539580 |
| Metastases to central nervous system | 39.95 | 14.30 | 45 | 33859 | 7086 | 29533537 |
| Stem cell transplant | 39.59 | 14.30 | 26 | 33878 | 1961 | 29538662 |
| Hypoaesthesia | 39.54 | 14.30 | 143 | 33761 | 53324 | 29487299 |
| Inappropriate schedule of product administration | 39.52 | 14.30 | 3 | 33901 | 44469 | 29496154 |
| Osteonecrosis of jaw | 39.22 | 14.30 | 69 | 33835 | 16441 | 29524182 |
| Hospitalisation | 38.44 | 14.30 | 4 | 33900 | 45984 | 29494639 |
| Adverse drug reaction | 37.27 | 14.30 | 84 | 33820 | 23936 | 29516687 |
| Pathological fracture | 35.78 | 14.30 | 32 | 33872 | 3823 | 29536800 |
| Neoplasm progression | 35.73 | 14.30 | 71 | 33833 | 18541 | 29522082 |
| Metastatic malignant melanoma | 34.35 | 14.30 | 23 | 33881 | 1792 | 29538831 |
| Bone sequestrum | 34.18 | 14.30 | 15 | 33889 | 498 | 29540125 |
| Sequestrectomy | 34.08 | 14.30 | 12 | 33892 | 218 | 29540405 |
| Pancytopenia | 33.76 | 14.30 | 186 | 33718 | 82982 | 29457641 |
| Metastasis | 32.89 | 14.30 | 29 | 33875 | 3400 | 29537223 |
| Jaw disorder | 32.23 | 14.30 | 23 | 33881 | 1987 | 29538636 |
| Asthenia | 31.97 | 14.30 | 382 | 33522 | 214868 | 29325755 |
| Rhabdomyolysis | 31.71 | 14.30 | 15 | 33889 | 60793 | 29479830 |
| Infusion related reaction | 31.58 | 14.30 | 6 | 33898 | 43880 | 29496743 |
| Headache | 31.27 | 14.30 | 99 | 33805 | 173908 | 29366715 |
| Therapy non-responder | 31.26 | 14.30 | 92 | 33812 | 30819 | 29509804 |
| Amyloidosis | 30.01 | 14.30 | 22 | 33882 | 1982 | 29538641 |
| Oral surgery | 29.87 | 14.30 | 14 | 33890 | 543 | 29540080 |
| Respiratory failure | 28.59 | 14.30 | 200 | 33704 | 96931 | 29443692 |
| Acute kidney injury | 28.38 | 14.30 | 183 | 33721 | 265084 | 29275539 |
| Blood creatine phosphokinase increased | 28.32 | 14.30 | 6 | 33898 | 40638 | 29499985 |
| Pain in jaw | 28.10 | 14.30 | 49 | 33855 | 11592 | 29529031 |
| Alanine aminotransferase increased | 28.09 | 14.30 | 24 | 33880 | 70920 | 29469703 |
| Blood pressure increased | 27.98 | 14.30 | 26 | 33878 | 73777 | 29466846 |
| Laboratory test abnormal | 27.55 | 14.30 | 63 | 33841 | 18122 | 29522501 |
| Drug ineffective | 27.17 | 14.30 | 276 | 33628 | 362894 | 29177729 |
| Hypoglycaemia | 26.66 | 14.30 | 11 | 33893 | 48335 | 29492288 |
| Failure to thrive | 26.37 | 14.30 | 38 | 33866 | 7646 | 29532977 |
| Cardiac failure congestive | 26.36 | 14.30 | 164 | 33740 | 76417 | 29464206 |
| Urticaria | 26.25 | 14.30 | 15 | 33889 | 54645 | 29485978 |
| Hypercalcaemia | 26.10 | 14.30 | 50 | 33854 | 12709 | 29527914 |
| Conjunctival irritation | 25.40 | 14.30 | 8 | 33896 | 101 | 29540522 |
| Osteolysis | 25.30 | 14.30 | 18 | 33886 | 1547 | 29539076 |
| Hip fracture | 25.11 | 14.30 | 44 | 33860 | 10448 | 29530175 |
| Cerebral toxoplasmosis | 24.56 | 14.30 | 17 | 33887 | 1399 | 29539224 |
| Insomnia | 24.46 | 14.30 | 40 | 33864 | 88721 | 29451902 |
| Peripheral sensory neuropathy | 24.34 | 14.30 | 32 | 33872 | 5907 | 29534716 |
| Diverticular perforation | 24.26 | 14.30 | 23 | 33881 | 2961 | 29537662 |
| Cardiac disorder | 23.69 | 14.30 | 95 | 33809 | 37168 | 29503455 |
| Paraesthesia | 23.59 | 14.30 | 123 | 33781 | 53722 | 29486901 |
| Diarrhoea | 23.18 | 14.30 | 257 | 33647 | 332441 | 29208182 |
| Enterococcal infection | 22.88 | 14.30 | 37 | 33867 | 8231 | 29532392 |
| Acute lymphocytic leukaemia | 22.77 | 14.30 | 21 | 33883 | 2610 | 29538013 |
| Intentional product misuse | 22.41 | 14.30 | 6 | 33898 | 34655 | 29505968 |
| Compression fracture | 22.39 | 14.30 | 21 | 33883 | 2667 | 29537956 |
| Varicella zoster virus infection | 21.72 | 14.30 | 16 | 33888 | 1452 | 29539171 |
| Genital erythema | 21.56 | 14.30 | 8 | 33896 | 170 | 29540453 |
| Blood bilirubin decreased | 21.48 | 14.30 | 9 | 33895 | 266 | 29540357 |
| Malignant neoplasm of unknown primary site | 21.45 | 14.30 | 10 | 33894 | 383 | 29540240 |
| Hyperviscosity syndrome | 21.17 | 14.30 | 8 | 33896 | 179 | 29540444 |
| Follicular mucinosis | 21.04 | 14.30 | 5 | 33899 | 19 | 29540604 |
| Arthralgia | 20.72 | 14.30 | 86 | 33818 | 139531 | 29401092 |
| Impaired healing | 20.57 | 14.30 | 47 | 33857 | 13511 | 29527112 |
| VIth nerve paralysis | 20.48 | 14.30 | 12 | 33892 | 739 | 29539884 |
| Jaw operation | 20.46 | 14.30 | 8 | 33896 | 197 | 29540426 |
| Laryngeal cancer metastatic | 20.41 | 14.30 | 6 | 33898 | 59 | 29540564 |
| Electrocardiogram QT prolonged | 20.29 | 14.30 | 8 | 33896 | 36129 | 29504494 |
| Infection | 20.26 | 14.30 | 154 | 33750 | 76597 | 29464026 |
| Hepatitis B | 20.07 | 14.30 | 28 | 33876 | 5469 | 29535154 |
| Aggression | 19.74 | 14.30 | 8 | 33896 | 35533 | 29505090 |
| Haemoglobin decreased | 19.55 | 14.30 | 200 | 33704 | 108175 | 29432448 |
| Wrong technique in product usage process | 19.29 | 14.30 | 6 | 33898 | 31422 | 29509201 |
| Lung infiltration | 19.17 | 14.30 | 42 | 33862 | 11737 | 29528886 |
| Suicidal ideation | 18.98 | 14.30 | 8 | 33896 | 34708 | 29505915 |
| Renal cell carcinoma | 18.78 | 14.30 | 25 | 33879 | 4671 | 29535952 |
| Flushing | 18.78 | 14.30 | 5 | 33899 | 28987 | 29511636 |
| Hepatic function abnormal | 18.53 | 14.30 | 11 | 33893 | 39248 | 29501375 |
| Genotoxicity | 18.38 | 14.30 | 5 | 33899 | 36 | 29540587 |
| Weight decreased | 18.27 | 14.30 | 100 | 33804 | 150805 | 29389818 |
| Hyponatraemia | 18.15 | 14.30 | 31 | 33873 | 67602 | 29473021 |
| Hypercapnic coma | 18.15 | 14.30 | 7 | 33897 | 166 | 29540457 |
| VIth nerve paresis | 17.60 | 14.30 | 5 | 33899 | 43 | 29540580 |
| Malaise | 17.59 | 14.30 | 109 | 33795 | 159493 | 29381130 |
| Incorrect dose administered | 17.40 | 14.30 | 8 | 33896 | 32976 | 29507647 |
| Anaphylactic reaction | 17.40 | 14.30 | 5 | 33899 | 27568 | 29513055 |
| Varicella | 17.39 | 14.30 | 14 | 33890 | 1449 | 29539174 |
| Abdominal pain | 17.33 | 14.30 | 88 | 33816 | 135269 | 29405354 |
| Aspartate aminotransferase increased | 17.32 | 14.30 | 26 | 33878 | 59699 | 29480924 |
| Agitation | 17.26 | 14.30 | 20 | 33884 | 51284 | 29489339 |
| Squamous cell carcinoma | 17.20 | 14.30 | 37 | 33867 | 10214 | 29530409 |
| Hallucination | 16.65 | 14.30 | 16 | 33888 | 44696 | 29495927 |
| Arachnoiditis | 16.45 | 14.30 | 8 | 33896 | 337 | 29540286 |
| Myalgia | 16.36 | 14.30 | 38 | 33866 | 73981 | 29466642 |
| Haematocrit decreased | 16.11 | 14.30 | 71 | 33833 | 28951 | 29511672 |
| Refractory cancer | 16.02 | 14.30 | 6 | 33898 | 131 | 29540492 |
| Neutropenic sepsis | 15.99 | 14.30 | 39 | 33865 | 11688 | 29528935 |
| Actinomycosis | 15.76 | 14.30 | 8 | 33896 | 370 | 29540253 |
| Acute generalised exanthematous pustulosis | 15.47 | 14.30 | 25 | 33879 | 5558 | 29535065 |
| Refractory anaemia with an excess of blasts | 15.39 | 14.30 | 8 | 33896 | 389 | 29540234 |
| Tachycardia | 15.35 | 14.30 | 38 | 33866 | 72372 | 29468251 |
| Bladder transitional cell carcinoma stage III | 15.33 | 14.30 | 4 | 33900 | 24 | 29540599 |
| Brain neoplasm malignant | 15.33 | 14.30 | 9 | 33895 | 556 | 29540067 |
| Hepatic enzyme increased | 15.21 | 14.30 | 10 | 33894 | 33789 | 29506834 |
| Rheumatoid arthritis | 15.18 | 14.30 | 9 | 33895 | 32143 | 29508480 |
| Metastatic neoplasm | 15.10 | 14.30 | 17 | 33887 | 2675 | 29537948 |
| Bone pain | 15.05 | 14.30 | 51 | 33853 | 18401 | 29522222 |
| Lymphocytic leukaemia | 14.93 | 14.30 | 6 | 33898 | 159 | 29540464 |
| Pallor | 14.86 | 14.30 | 3 | 33901 | 21021 | 29519602 |
| Brain cancer metastatic | 14.85 | 14.30 | 5 | 33899 | 79 | 29540544 |
| Malignant melanoma | 14.57 | 14.30 | 28 | 33876 | 7133 | 29533490 |
| Musculoskeletal stiffness | 14.42 | 14.30 | 13 | 33891 | 37445 | 29503178 |
| Cachexia | 14.39 | 14.30 | 26 | 33878 | 6323 | 29534300 |
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Disease progression | 3795.63 | 13.50 | 1929 | 46664 | 139751 | 64310388 |
| Death | 3162.87 | 13.50 | 2714 | 45879 | 479991 | 63970148 |
| Plasma cell myeloma | 1252.00 | 13.50 | 636 | 47957 | 45439 | 64404700 |
| Neuropathy peripheral | 827.27 | 13.50 | 694 | 47899 | 116831 | 64333308 |
| Malignant neoplasm progression | 782.97 | 13.50 | 661 | 47932 | 112210 | 64337929 |
| Human chorionic gonadotropin increased | 457.42 | 13.50 | 111 | 48482 | 775 | 64449364 |
| Plasma cell myeloma recurrent | 448.71 | 13.50 | 153 | 48440 | 3912 | 64446227 |
| Deep vein thrombosis | 443.95 | 13.50 | 468 | 48125 | 104714 | 64345425 |
| Osteonecrosis | 412.77 | 13.50 | 260 | 48333 | 27969 | 64422170 |
| Pneumonia | 301.17 | 13.50 | 1014 | 47579 | 558562 | 63891577 |
| Plasmacytoma | 263.62 | 13.50 | 102 | 48491 | 3768 | 64446371 |
| Renal failure | 230.67 | 13.50 | 456 | 48137 | 181232 | 64268907 |
| Pulmonary embolism | 204.93 | 13.50 | 383 | 48210 | 145973 | 64304166 |
| Acute myeloid leukaemia | 184.09 | 13.50 | 158 | 48435 | 27305 | 64422834 |
| Unevaluable event | 158.74 | 13.50 | 193 | 48400 | 50296 | 64399843 |
| Sepsis | 156.96 | 13.50 | 454 | 48139 | 229887 | 64220252 |
| Plasma cell leukaemia | 138.95 | 13.50 | 50 | 48543 | 1503 | 64448636 |
| Polyneuropathy | 136.47 | 13.50 | 116 | 48477 | 19778 | 64430361 |
| Completed suicide | 133.94 | 13.50 | 9 | 48584 | 224405 | 64225734 |
| Drug interaction | 128.61 | 13.50 | 56 | 48537 | 362027 | 64088112 |
| Tooth extraction | 126.82 | 13.50 | 83 | 48510 | 9518 | 64440621 |
| Myelodysplastic syndrome | 125.62 | 13.50 | 128 | 48465 | 27451 | 64422688 |
| Squamous cell carcinoma of skin | 115.37 | 13.50 | 85 | 48508 | 11791 | 64438348 |
| Rheumatoid arthritis | 109.77 | 13.50 | 3 | 48590 | 164291 | 64285848 |
| Bone disorder | 105.40 | 13.50 | 93 | 48500 | 16666 | 64433473 |
| Headache | 103.82 | 13.50 | 149 | 48444 | 529318 | 63920821 |
| Drug hypersensitivity | 103.23 | 13.50 | 26 | 48567 | 237789 | 64212350 |
| Arthralgia | 102.92 | 13.50 | 109 | 48484 | 442151 | 64007988 |
| Pregnancy test urine positive | 92.59 | 13.50 | 16 | 48577 | 8 | 64450131 |
| Pancytopenia | 89.43 | 13.50 | 274 | 48319 | 143035 | 64307104 |
| Pruritus | 87.02 | 13.50 | 65 | 48528 | 312335 | 64137804 |
| Basal cell carcinoma | 85.91 | 13.50 | 111 | 48482 | 30727 | 64419412 |
| Acute leukaemia | 84.16 | 13.50 | 35 | 48558 | 1563 | 64448576 |
| Overdose | 83.03 | 13.50 | 11 | 48582 | 159555 | 64290584 |
| Leukaemia | 82.27 | 13.50 | 50 | 48543 | 5038 | 64445101 |
| Constipation | 79.64 | 13.50 | 363 | 48230 | 228974 | 64221165 |
| Metastases to central nervous system | 77.27 | 13.50 | 72 | 48521 | 13840 | 64436299 |
| Hepatosplenic T-cell lymphoma | 75.55 | 13.50 | 27 | 48566 | 795 | 64449344 |
| Metastatic malignant melanoma | 74.50 | 13.50 | 37 | 48556 | 2504 | 64447635 |
| Infusion related reaction | 73.26 | 13.50 | 17 | 48576 | 164450 | 64285689 |
| Varicella zoster virus infection | 72.79 | 13.50 | 42 | 48551 | 3846 | 64446293 |
| Human chorionic gonadotropin positive | 72.36 | 13.50 | 14 | 48579 | 25 | 64450114 |
| Injection site pain | 71.01 | 13.50 | 3 | 48590 | 111405 | 64338734 |
| Cardiac failure congestive | 69.96 | 13.50 | 237 | 48356 | 130343 | 64319796 |
| Complications of bone marrow transplant | 66.56 | 13.50 | 23 | 48570 | 612 | 64449527 |
| Stem cell transplant | 66.23 | 13.50 | 38 | 48555 | 3443 | 64446696 |
| Haemoglobin decreased | 65.65 | 13.50 | 306 | 48287 | 194757 | 64255382 |
| Thrombosis | 64.02 | 13.50 | 155 | 48438 | 70487 | 64379652 |
| Arthropathy | 63.74 | 13.50 | 8 | 48585 | 120959 | 64329180 |
| Bone debridement | 62.11 | 13.50 | 20 | 48573 | 425 | 64449714 |
| Oedema peripheral | 60.84 | 13.50 | 316 | 48277 | 210001 | 64240138 |
| Bone lesion | 59.66 | 13.50 | 41 | 48552 | 5096 | 64445043 |
| Drug ineffective | 58.23 | 13.50 | 383 | 48210 | 839864 | 63610275 |
| Alopecia | 58.14 | 13.50 | 26 | 48567 | 165664 | 64284475 |
| Full blood count decreased | 57.82 | 13.50 | 78 | 48515 | 22504 | 64427635 |
| Amyloidosis | 57.79 | 13.50 | 31 | 48562 | 2463 | 64447676 |
| Oral surgery | 57.18 | 13.50 | 23 | 48570 | 942 | 64449197 |
| Inappropriate schedule of product administration | 57.14 | 13.50 | 3 | 48590 | 92283 | 64357856 |
| Osteonecrosis of jaw | 56.59 | 13.50 | 105 | 48488 | 39720 | 64410419 |
| Respiratory failure | 56.55 | 13.50 | 256 | 48337 | 160927 | 64289212 |
| Thrombocytopenia | 55.83 | 13.50 | 323 | 48270 | 223478 | 64226661 |
| Jaw operation | 55.25 | 13.50 | 21 | 48572 | 738 | 64449401 |
| Malaise | 54.31 | 13.50 | 138 | 48455 | 396109 | 64054030 |
| Pain | 54.19 | 13.50 | 224 | 48369 | 553287 | 63896852 |
| Osteomyelitis | 54.14 | 13.50 | 84 | 48509 | 27503 | 64422636 |
| Weight increased | 53.66 | 13.50 | 49 | 48544 | 213299 | 64236840 |
| Therapeutic product effect decreased | 53.23 | 13.50 | 11 | 48582 | 115340 | 64334799 |
| Haematocrit decreased | 52.85 | 13.50 | 123 | 48470 | 54532 | 64395607 |
| Musculoskeletal stiffness | 52.40 | 13.50 | 14 | 48579 | 123192 | 64326947 |
| Joint swelling | 52.37 | 13.50 | 51 | 48542 | 215331 | 64234808 |
| Spinal cord compression | 51.33 | 13.50 | 39 | 48554 | 5664 | 64444475 |
| Acute lymphocytic leukaemia | 51.03 | 13.50 | 35 | 48558 | 4336 | 64445803 |
| Abdominal discomfort | 50.63 | 13.50 | 38 | 48555 | 182284 | 64267855 |
| Nasopharyngitis | 50.54 | 13.50 | 44 | 48549 | 196029 | 64254110 |
| Diverticular perforation | 49.93 | 13.50 | 37 | 48556 | 5176 | 64444963 |
| Hypersensitivity | 49.54 | 13.50 | 45 | 48548 | 196407 | 64253732 |
| Therapy non-responder | 48.77 | 13.50 | 134 | 48459 | 65765 | 64384374 |
| Human chorionic gonadotropin abnormal | 47.69 | 13.50 | 9 | 48584 | 13 | 64450126 |
| Asthenia | 47.54 | 13.50 | 512 | 48081 | 427532 | 64022607 |
| Synovitis | 46.66 | 13.50 | 9 | 48584 | 99081 | 64351058 |
| Debridement | 45.68 | 13.50 | 23 | 48570 | 1603 | 64448536 |
| Hepatic enzyme increased | 44.63 | 13.50 | 21 | 48572 | 129922 | 64320217 |
| Neoplasm progression | 42.72 | 13.50 | 95 | 48498 | 40869 | 64409270 |
| Peripheral sensory neuropathy | 41.56 | 13.50 | 47 | 48546 | 11331 | 64438808 |
| Large intestinal ulcer perforation | 41.56 | 13.50 | 10 | 48583 | 67 | 64450072 |
| Refractory cytopenia with multilineage dysplasia | 41.21 | 13.50 | 13 | 48580 | 258 | 64449881 |
| Mesenteric abscess | 41.12 | 13.50 | 11 | 48582 | 118 | 64450021 |
| Renal cell carcinoma | 40.64 | 13.50 | 35 | 48558 | 6069 | 64444070 |
| Anxiety | 40.61 | 13.50 | 56 | 48537 | 202593 | 64247546 |
| Type 2 lepra reaction | 40.10 | 13.50 | 12 | 48581 | 198 | 64449941 |
| VIth nerve paresis | 40.07 | 13.50 | 11 | 48582 | 131 | 64450008 |
| Pleural effusion | 39.97 | 13.50 | 195 | 48398 | 126364 | 64323775 |
| Hypercalcaemia | 39.92 | 13.50 | 79 | 48514 | 31337 | 64418802 |
| Platelet count decreased | 39.18 | 13.50 | 238 | 48355 | 167473 | 64282666 |
| Suicide attempt | 39.15 | 13.50 | 4 | 48589 | 71003 | 64379136 |
| Injection site erythema | 39.00 | 13.50 | 4 | 48589 | 70796 | 64379343 |
| Metastasis | 38.62 | 13.50 | 33 | 48560 | 5662 | 64444477 |
| Pregnancy of partner | 38.04 | 13.50 | 12 | 48581 | 238 | 64449901 |
| Urticaria | 38.02 | 13.50 | 33 | 48560 | 147284 | 64302855 |
| Actinomycosis | 37.71 | 13.50 | 17 | 48576 | 925 | 64449214 |
| Body dysmorphic disorder | 37.63 | 13.50 | 12 | 48581 | 247 | 64449892 |
| Blood pressure increased | 37.34 | 13.50 | 45 | 48548 | 172507 | 64277632 |
| Bone sequestrum | 37.15 | 13.50 | 18 | 48575 | 1154 | 64448985 |
| Rhesus antigen positive | 36.06 | 13.50 | 10 | 48583 | 124 | 64450015 |
| Migraine | 35.97 | 13.50 | 3 | 48590 | 62674 | 64387465 |
| Enterococcal infection | 35.66 | 13.50 | 48 | 48545 | 13818 | 64436321 |
| Hair follicle tumour benign | 35.18 | 13.50 | 13 | 48580 | 422 | 64449717 |
| Hospitalisation | 35.05 | 13.50 | 7 | 48586 | 75200 | 64374939 |
| Glossodynia | 34.76 | 13.50 | 4 | 48589 | 64692 | 64385447 |
| Lung infiltration | 34.72 | 13.50 | 59 | 48534 | 20830 | 64429309 |
| Failure to thrive | 34.69 | 13.50 | 41 | 48552 | 10363 | 64439776 |
| Stress | 34.46 | 13.50 | 3 | 48590 | 60531 | 64389608 |
| Nasal abscess | 34.43 | 13.50 | 10 | 48583 | 148 | 64449991 |
| Pathological fracture | 34.27 | 13.50 | 38 | 48555 | 8967 | 64441172 |
| Wound | 33.85 | 13.50 | 8 | 48585 | 76469 | 64373670 |
| Electrocardiogram QT prolonged | 33.83 | 13.50 | 9 | 48584 | 79439 | 64370700 |
| Progressive multifocal leukoencephalopathy | 33.68 | 13.50 | 54 | 48539 | 18178 | 64431961 |
| Insomnia | 33.63 | 13.50 | 61 | 48532 | 197775 | 64252364 |
| Pregnancy test false positive | 33.44 | 13.50 | 9 | 48584 | 99 | 64450040 |
| Hip fracture | 33.06 | 13.50 | 67 | 48526 | 27032 | 64423107 |
| Mucosal inflammation | 32.96 | 13.50 | 113 | 48480 | 62471 | 64387668 |
| Gastrointestinal fungal infection | 32.87 | 13.50 | 12 | 48581 | 376 | 64449763 |
| Exposure during pregnancy | 32.70 | 13.50 | 9 | 48584 | 77666 | 64372473 |
| Myalgia | 32.61 | 13.50 | 43 | 48550 | 158574 | 64291565 |
| Osteolysis | 31.67 | 13.50 | 22 | 48571 | 2781 | 64447358 |
| Flushing | 31.49 | 13.50 | 10 | 48583 | 78638 | 64371501 |
| Alanine aminotransferase increased | 31.43 | 13.50 | 35 | 48558 | 138996 | 64311143 |
| Laboratory test abnormal | 31.16 | 13.50 | 61 | 48532 | 24002 | 64426137 |
| Anaemia | 31.10 | 13.50 | 428 | 48165 | 378252 | 64071887 |
| Prothrombin time prolonged | 30.98 | 13.50 | 48 | 48545 | 15693 | 64434446 |
| Wrong technique in product usage process | 30.38 | 13.50 | 6 | 48587 | 64968 | 64385171 |
| Diarrhoea | 30.32 | 13.50 | 374 | 48219 | 722330 | 63727809 |
| Pregnancy test positive | 30.23 | 13.50 | 8 | 48585 | 82 | 64450057 |
| Chronic kidney disease | 30.00 | 13.50 | 104 | 48489 | 57815 | 64392324 |
| Rhabdomyolysis | 29.73 | 13.50 | 16 | 48577 | 91710 | 64358429 |
| Nausea | 29.55 | 13.50 | 416 | 48177 | 785384 | 63664755 |
| Rectal adenocarcinoma | 29.19 | 13.50 | 16 | 48577 | 1327 | 64448812 |
| Endocarditis bacterial | 29.19 | 13.50 | 16 | 48577 | 1327 | 64448812 |
| Staphylococcal bacteraemia | 28.41 | 13.50 | 37 | 48556 | 10318 | 64439821 |
| Angioedema | 28.30 | 13.50 | 6 | 48587 | 61815 | 64388324 |
| Hypoglossal nerve paresis | 28.29 | 13.50 | 8 | 48585 | 107 | 64450032 |
| JC virus infection | 28.13 | 13.50 | 22 | 48571 | 3333 | 64446806 |
| Condition aggravated | 28.12 | 13.50 | 165 | 48428 | 372261 | 64077878 |
| Oxygen saturation decreased | 27.66 | 13.50 | 24 | 48569 | 107152 | 64342987 |
| Sinus polyp | 27.47 | 13.50 | 11 | 48582 | 445 | 64449694 |
| Conjunctival irritation | 26.97 | 13.50 | 8 | 48585 | 128 | 64450011 |
| Malignant neoplasm of unknown primary site | 26.27 | 13.50 | 12 | 48581 | 673 | 64449466 |
| Jaw disorder | 25.84 | 13.50 | 24 | 48569 | 4593 | 64445546 |
| Incorrect dose administered | 25.65 | 13.50 | 7 | 48586 | 60758 | 64389381 |
| Therapy partial responder | 25.63 | 13.50 | 35 | 48558 | 10213 | 64439926 |
| Nocardiosis | 25.18 | 13.50 | 24 | 48569 | 4743 | 64445396 |
| Blood immunoglobulin M decreased | 24.98 | 13.50 | 13 | 48580 | 971 | 64449168 |
| Joint ankylosis | 24.95 | 13.50 | 12 | 48581 | 757 | 64449382 |
| Morganella infection | 24.71 | 13.50 | 13 | 48580 | 993 | 64449146 |
| Clostridium bacteraemia | 24.68 | 13.50 | 9 | 48584 | 281 | 64449858 |
| B precursor type acute leukaemia | 24.42 | 13.50 | 9 | 48584 | 290 | 64449849 |
| Blood albumin decreased | 24.41 | 13.50 | 51 | 48542 | 21022 | 64429117 |
| Intentional product misuse | 24.33 | 13.50 | 12 | 48581 | 72283 | 64377856 |
| Light chain analysis increased | 24.14 | 13.50 | 14 | 48579 | 1294 | 64448845 |
| Oropharyngeal pain | 24.04 | 13.50 | 19 | 48574 | 88848 | 64361291 |
| Blood pressure fluctuation | 23.81 | 13.50 | 5 | 48588 | 51866 | 64398273 |
| Syncope | 23.60 | 13.50 | 201 | 48392 | 157434 | 64292705 |
| Cardiopulmonary failure | 23.41 | 13.50 | 26 | 48567 | 6144 | 64443995 |
| Blood immunoglobulin G decreased | 23.38 | 13.50 | 18 | 48575 | 2665 | 64447474 |
| Hyperbaric oxygen therapy | 23.38 | 13.50 | 6 | 48587 | 54 | 64450085 |
| Hypoglycaemia | 23.35 | 13.50 | 20 | 48573 | 89872 | 64360267 |
| Infection | 23.24 | 13.50 | 227 | 48366 | 184653 | 64265486 |
| Pericarditis | 23.22 | 13.50 | 9 | 48584 | 62507 | 64387632 |
| Cardiac amyloidosis | 23.12 | 13.50 | 14 | 48579 | 1401 | 64448738 |
| Genital erythema | 23.00 | 13.50 | 8 | 48585 | 217 | 64449922 |
| Dehydration | 22.93 | 13.50 | 257 | 48336 | 216506 | 64233633 |
| Metastatic neoplasm | 22.78 | 13.50 | 22 | 48571 | 4420 | 64445719 |
| Hyperviscosity syndrome | 22.72 | 13.50 | 9 | 48584 | 354 | 64449785 |
| Follicular mucinosis | 22.54 | 13.50 | 5 | 48588 | 22 | 64450117 |
| Blood creatine phosphokinase increased | 22.47 | 13.50 | 8 | 48585 | 58550 | 64391589 |
| Acute generalised exanthematous pustulosis | 22.44 | 13.50 | 39 | 48554 | 14019 | 64436120 |
| Mobility decreased | 22.42 | 13.50 | 19 | 48574 | 85821 | 64364318 |
| Contusion | 22.31 | 13.50 | 32 | 48561 | 113933 | 64336206 |
| Clostridium colitis | 22.14 | 13.50 | 17 | 48576 | 2508 | 64447631 |
| Aspartate aminotransferase increased | 22.13 | 13.50 | 35 | 48558 | 119753 | 64330386 |
| Blood immunoglobulin G increased | 22.10 | 13.50 | 15 | 48578 | 1826 | 64448313 |
| Weight decreased | 21.87 | 13.50 | 126 | 48467 | 285613 | 64164526 |
| Hepatitis B | 21.75 | 13.50 | 28 | 48565 | 7717 | 64442422 |
| Abdominal pain | 21.69 | 13.50 | 142 | 48451 | 312233 | 64137906 |
| Posterior reversible encephalopathy syndrome | 21.47 | 13.50 | 51 | 48542 | 22895 | 64427244 |
| Cytomegalovirus infection reactivation | 21.40 | 13.50 | 24 | 48569 | 5732 | 64444407 |
| Chest discomfort | 21.37 | 13.50 | 34 | 48559 | 116072 | 64334067 |
| Monoclonal immunoglobulin present | 20.98 | 13.50 | 11 | 48582 | 834 | 64449305 |
| Sequestrectomy | 20.93 | 13.50 | 11 | 48582 | 838 | 64449301 |
| Abdominal pain upper | 20.93 | 13.50 | 65 | 48528 | 174965 | 64275174 |
| Cachexia | 20.85 | 13.50 | 30 | 48563 | 9187 | 64440952 |
| Off label use | 20.67 | 13.50 | 344 | 48249 | 632462 | 63817677 |
| Febrile neutropenia | 20.53 | 13.50 | 224 | 48369 | 187433 | 64262706 |
| Neutropenia | 20.52 | 13.50 | 273 | 48320 | 239351 | 64210788 |
| Intentional product use issue | 20.48 | 13.50 | 25 | 48568 | 95339 | 64354800 |
| Peripheral swelling | 20.16 | 13.50 | 85 | 48508 | 209068 | 64241071 |
| Large intestine perforation | 20.16 | 13.50 | 35 | 48558 | 12569 | 64437570 |
| Erythema | 19.96 | 13.50 | 73 | 48520 | 186997 | 64263142 |
| Septic shock | 19.96 | 13.50 | 142 | 48451 | 105295 | 64344844 |
| Nasal congestion | 19.93 | 13.50 | 10 | 48583 | 59648 | 64390491 |
| Blister | 19.86 | 13.50 | 19 | 48574 | 80948 | 64369191 |
| Gastrooesophageal reflux disease | 19.83 | 13.50 | 20 | 48573 | 83123 | 64367016 |
| Feeling hot | 19.77 | 13.50 | 5 | 48588 | 45658 | 64404481 |
| Hepatic function abnormal | 19.72 | 13.50 | 12 | 48581 | 64301 | 64385838 |
| Wheezing | 19.66 | 13.50 | 19 | 48574 | 80560 | 64369579 |
| Dental care | 19.41 | 13.50 | 10 | 48583 | 731 | 64449408 |
| Mucosal erosion | 19.14 | 13.50 | 14 | 48579 | 1920 | 64448219 |
| Laryngeal cancer metastatic | 19.01 | 13.50 | 5 | 48588 | 50 | 64450089 |
| Drug intolerance | 19.00 | 13.50 | 75 | 48518 | 187917 | 64262222 |
| White blood cell count decreased | 18.96 | 13.50 | 192 | 48401 | 157645 | 64292494 |
| Blood cholesterol increased | 18.94 | 13.50 | 7 | 48586 | 50059 | 64400080 |
| Refractory cancer | 18.89 | 13.50 | 7 | 48586 | 229 | 64449910 |
| Staphylococcal infection | 18.88 | 13.50 | 82 | 48511 | 50596 | 64399543 |
| Cellulitis staphylococcal | 18.78 | 13.50 | 11 | 48582 | 1036 | 64449103 |
| Cardiac disorder | 18.32 | 13.50 | 87 | 48506 | 55729 | 64394410 |
| Aggression | 18.29 | 13.50 | 6 | 48587 | 46226 | 64403913 |
| Hodgkin's disease | 18.22 | 13.50 | 10 | 48583 | 831 | 64449308 |
| Bacteraemia | 18.22 | 13.50 | 53 | 48540 | 26858 | 64423281 |
| Anaphylactic reaction | 18.18 | 13.50 | 15 | 48578 | 68649 | 64381490 |
| Refractory anaemia with an excess of blasts | 18.17 | 13.50 | 10 | 48583 | 836 | 64449303 |
| Prostate cancer metastatic | 18.15 | 13.50 | 17 | 48576 | 3287 | 64446852 |
| Hypoaesthesia | 18.06 | 13.50 | 172 | 48421 | 138936 | 64311203 |
| Encephalopathy | 18.00 | 13.50 | 11 | 48582 | 58808 | 64391331 |
| Arthritis | 17.97 | 13.50 | 22 | 48571 | 83792 | 64366347 |
| Graft versus host disease | 17.87 | 13.50 | 35 | 48558 | 13778 | 64436361 |
| Musculoskeletal pain | 17.79 | 13.50 | 21 | 48572 | 81273 | 64368866 |
| Injection site bruising | 17.77 | 13.50 | 3 | 48590 | 36370 | 64413769 |
| VIth nerve paralysis | 17.73 | 13.50 | 12 | 48581 | 1454 | 64448685 |
| Pain in extremity | 17.57 | 13.50 | 145 | 48448 | 302940 | 64147199 |
| Therapeutic product effect incomplete | 17.49 | 13.50 | 32 | 48561 | 103450 | 64346689 |
| Hypoxia | 17.44 | 13.50 | 120 | 48473 | 88029 | 64362110 |
| Dialysis | 17.37 | 13.50 | 39 | 48554 | 16881 | 64433258 |
| Paraesthesia | 17.30 | 13.50 | 166 | 48427 | 134356 | 64315783 |
| General physical condition abnormal | 17.28 | 13.50 | 21 | 48572 | 5461 | 64444678 |
| Systemic lupus erythematosus | 17.03 | 13.50 | 20 | 48573 | 77592 | 64372547 |
| Blood pressure systolic increased | 16.96 | 13.50 | 8 | 48585 | 49445 | 64400694 |
| Lactic acidosis | 16.77 | 13.50 | 13 | 48580 | 61397 | 64388742 |
| Bone trimming | 16.73 | 13.50 | 4 | 48589 | 26 | 64450113 |
| Endothelial dysfunction | 16.62 | 13.50 | 6 | 48587 | 182 | 64449957 |
| Hot flush | 16.61 | 13.50 | 7 | 48586 | 46228 | 64403911 |
| Duodenal ulcer perforation | 16.60 | 13.50 | 3 | 48590 | 34622 | 64415517 |
| Bladder transitional cell carcinoma stage III | 16.60 | 13.50 | 4 | 48589 | 27 | 64450112 |
| Discomfort | 16.54 | 13.50 | 22 | 48571 | 80856 | 64369283 |
| Intestinal perforation | 16.51 | 13.50 | 36 | 48557 | 15277 | 64434862 |
| Bence Jones protein urine present | 16.50 | 13.50 | 3 | 48590 | 3 | 64450136 |
| Compression fracture | 16.48 | 13.50 | 21 | 48572 | 5731 | 64444408 |
| Immunoglobulins decreased | 16.45 | 13.50 | 11 | 48582 | 1307 | 64448832 |
| Feeling abnormal | 16.41 | 13.50 | 49 | 48544 | 133553 | 64316586 |
| Infection reactivation | 16.35 | 13.50 | 13 | 48580 | 2017 | 64448122 |
| Cerebrovascular accident | 16.34 | 13.50 | 167 | 48426 | 137416 | 64312723 |
| Heart rate increased | 16.25 | 13.50 | 31 | 48562 | 98644 | 64351495 |
| Lung neoplasm malignant | 16.24 | 13.50 | 44 | 48549 | 21404 | 64428735 |
| Depression | 16.15 | 13.50 | 77 | 48516 | 183214 | 64266925 |
| Agitation | 16.15 | 13.50 | 26 | 48567 | 88341 | 64361798 |
| Blood albumin increased | 16.06 | 13.50 | 11 | 48582 | 1360 | 64448779 |
| Enterococcal sepsis | 16.00 | 13.50 | 14 | 48579 | 2480 | 64447659 |
| Protein total increased | 15.95 | 13.50 | 16 | 48577 | 3365 | 64446774 |
| Blood luteinising hormone increased | 15.94 | 13.50 | 6 | 48587 | 205 | 64449934 |
| Atelectasis | 15.93 | 13.50 | 51 | 48542 | 27215 | 64422924 |
| Accidental overdose | 15.89 | 13.50 | 3 | 48590 | 33554 | 64416585 |
| Oedema | 15.79 | 13.50 | 121 | 48472 | 91814 | 64358325 |
| Medication error | 15.77 | 13.50 | 9 | 48584 | 49957 | 64400182 |
| Hypercapnic coma | 15.46 | 13.50 | 7 | 48586 | 385 | 64449754 |
| Squamous cell carcinoma | 15.41 | 13.50 | 33 | 48560 | 13836 | 64436303 |
| Osteoarthritis | 15.37 | 13.50 | 15 | 48578 | 63321 | 64386818 |
| Bence Jones proteinuria | 15.28 | 13.50 | 3 | 48590 | 6 | 64450133 |
| Strongyloidiasis | 15.28 | 13.50 | 15 | 48578 | 3075 | 64447064 |
| Atrial fibrillation | 15.09 | 13.50 | 196 | 48397 | 170893 | 64279246 |
| Fibrous dysplasia of bone | 14.97 | 13.50 | 3 | 48590 | 7 | 64450132 |
| Diverticulitis | 14.78 | 13.50 | 63 | 48530 | 38555 | 64411584 |
| Loss of personal independence in daily activities | 14.52 | 13.50 | 20 | 48573 | 72434 | 64377705 |
| Prostate cancer | 14.39 | 13.50 | 40 | 48553 | 19755 | 64430384 |
| Pneumonia parainfluenzae viral | 14.34 | 13.50 | 6 | 48587 | 272 | 64449867 |
| Chloroma | 14.23 | 13.50 | 8 | 48585 | 697 | 64449442 |
| Irritability | 14.13 | 13.50 | 5 | 48588 | 36741 | 64413398 |
| Blood culture positive | 14.12 | 13.50 | 23 | 48570 | 7845 | 64442294 |
| Dyskinesia | 14.09 | 13.50 | 6 | 48587 | 39382 | 64410757 |
| Renal amyloidosis | 14.06 | 13.50 | 5 | 48588 | 145 | 64449994 |
| Procalcitonin increased | 14.04 | 13.50 | 13 | 48580 | 2478 | 64447661 |
| Light chain analysis | 13.96 | 13.50 | 3 | 48590 | 11 | 64450128 |
| Vomiting | 13.87 | 13.50 | 313 | 48280 | 550804 | 63899335 |
| Hyperhidrosis | 13.82 | 13.50 | 48 | 48545 | 124872 | 64325267 |
| Swelling | 13.71 | 13.50 | 68 | 48525 | 160150 | 64289989 |
| Peripheral sensorimotor neuropathy | 13.63 | 13.50 | 13 | 48580 | 2572 | 64447567 |
| Folliculitis | 13.60 | 13.50 | 3 | 48590 | 30074 | 64420065 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | L04AX02 | ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS IMMUNOSUPPRESSANTS IMMUNOSUPPRESSANTS Other immunosuppressants |
| FDA PE | N0000008663 | Decreased Immunologically Active Molecule Activity |
| MeSH PA | D020533 | Angiogenesis Inhibitors |
| MeSH PA | D000900 | Anti-Bacterial Agents |
| MeSH PA | D000890 | Anti-Infective Agents |
| MeSH PA | D000970 | Antineoplastic Agents |
| MeSH PA | D006131 | Growth Inhibitors |
| MeSH PA | D006133 | Growth Substances |
| MeSH PA | D007155 | Immunologic Factors |
| MeSH PA | D007166 | Immunosuppressive Agents |
| MeSH PA | D007917 | Leprostatic Agents |
| MeSH PA | D009676 | Noxae |
| MeSH PA | D013723 | Teratogens |
| CHEBI has role | CHEBI:35472 | anti-inflammatory drugs |
| CHEBI has role | CHEBI:35610 | antineoplastic agents |
| CHEBI has role | CHEBI:35623 | anticonvulsants |
| CHEBI has role | CHEBI:35705 | immunosuppressive agents |
| CHEBI has role | CHEBI:35717 | hypnotics |
| CHEBI has role | CHEBI:35816 | leprostatic drugs |
| CHEBI has role | CHEBI:48422 | angiogenesis antagonist |
| CHEBI has role | CHEBI:50905 | teratogeno |
| CHEBI has role | CHEBI:50919 | antiemetico |
Drug Use (View source of the data)
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Crow-Fukase (POEMS) syndrome | indication | 79268002 | DOID:14039 |
| Multiple myeloma | indication | 109989006 | DOID:9538 |
| Erythema nodosum leprosum | indication | 240411003 | |
| Refractory upper gastrointestinal bleeding due to angiodysplasia | off-label use | 37372002 | |
| Pyoderma gangrenosum | off-label use | 74578003 | DOID:8553 |
| Discoid lupus erythematosus | off-label use | 200938002 | |
| Actinic prurigo | off-label use | 201015007 | |
| Graft-versus-host disease | off-label use | 234646005 | |
| Erosive oral lichen planus | off-label use | 238662007 | |
| Subacute cutaneous lupus erythematosus | off-label use | 239891002 | |
| Recurrent aphthous ulcer | off-label use | 398870000 | |
| Refractory upper gastrointestinal bleeding due to angiodysplasia | off-label use | 29731000119103 | |
| Refractory upper gastrointestinal bleeding due to angiodysplasia | off-label use | 1082711000119110 | |
| Prevention of Recurrent Aphthous Stomatitis | off-label use | ||
| Orthostatic hypotension | contraindication | 28651003 | |
| Bradycardia | contraindication | 48867003 | |
| Epilepsy | contraindication | 84757009 | DOID:1826 |
| Deep venous thrombosis | contraindication | 128053003 | |
| Pulmonary thromboembolism | contraindication | 233935004 | |
| Pregnancy, function | contraindication | 289908002 | |
| Peripheral nerve disease | contraindication | 302226006 | |
| Neutropenic disorder | contraindication | 303011007 | DOID:1227 |
| Thromboembolic disorder | contraindication | 371039008 | |
| Breastfeeding (mother) | contraindication | 413712001 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 7.84 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Protein cereblon | Cytosolic other | MODULATOR | EC50 | 6.39 | SCIENTIFIC LITERATURE | SCIENTIFIC LITERATURE | |||
| Prostaglandin G/H synthase 1 | Enzyme | IC50 | 6.43 | WOMBAT-PK | |||||
| Tumor necrosis factor | Cytokine | IC50 | 8 | WOMBAT-PK | |||||
| Prostaglandin G/H synthase 2 | Enzyme | IC50 | 6.30 | WOMBAT-PK | |||||
| Prostaglandin G/H synthase 2 | Enzyme | IC50 | 6.30 | CHEMBL | |||||
| Cereblon isoform 4 | Unclassified | Ki | 5.36 | CHEMBL | |||||
| Prostaglandin G/H synthase 1 | Enzyme | IC50 | 6.43 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4021134 | VUID |
| N0000148588 | NUI |
| D00754 | KEGG_DRUG |
| 4021134 | VANDF |
| C0039736 | UMLSCUI |
| CHEBI:9513 | CHEBI |
| CHEMBL468 | ChEMBL_ID |
| DB01041 | DRUGBANK_ID |
| D013792 | MESH_DESCRIPTOR_UI |
| 5426 | PUBCHEM_CID |
| 7327 | IUPHAR_LIGAND_ID |
| 762 | INN_ID |
| 4Z8R6ORS6L | UNII |
| 10432 | RXNORM |
| 11845 | MMSL |
| 7488 | MMSL |
| d04331 | MMSL |
| 005933 | NDDF |
| 404878004 | SNOMEDCT_US |
| 78702007 | SNOMEDCT_US |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Thalomid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 59572-205 | CAPSULE | 50 mg | ORAL | NDA | 30 sections |
| Thalomid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 59572-205 | CAPSULE | 50 mg | ORAL | NDA | 30 sections |
| Thalomid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 59572-210 | CAPSULE | 100 mg | ORAL | NDA | 30 sections |
| Thalomid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 59572-210 | CAPSULE | 100 mg | ORAL | NDA | 30 sections |
| Thalomid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 59572-215 | CAPSULE | 150 mg | ORAL | NDA | 30 sections |
| Thalomid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 59572-215 | CAPSULE | 150 mg | ORAL | NDA | 30 sections |
| Thalomid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 59572-220 | CAPSULE | 200 mg | ORAL | NDA | 30 sections |
| Thalomid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 59572-220 | CAPSULE | 200 mg | ORAL | NDA | 30 sections |