methotrexate Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
folic acid analogues 1751 59-05-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • methotrexate
  • methotrexate sodium
  • amethopterin
  • amethopterine
  • L-Amethopterin
  • ledertrexate
  • metatrexan
  • methoxtrexate
  • methylaminopterin
An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.
  • Molecular weight: 454.45
  • Formula: C20H22N8O5
  • CLOGP: -0.53
  • LIPINSKI: 1
  • HAC: 13
  • HDO: 5
  • TPSA: 210.54
  • ALOGS: -3.42
  • ROTB: 9

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
2.50 mg O
2.50 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.45 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 81 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 1.10 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 33 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.43 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 2.10 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.37 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 3.90 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Dec. 7, 1953 FDA DAVA PHARMS INC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 14992.61 11.08 30841 633702 646997 45374522
Rheumatoid arthritis 8649.62 11.08 13582 650961 226633 45794886
Drug intolerance 5187.12 11.08 8250 656293 138799 45882720
Treatment failure 3917.93 11.08 5674 658869 87413 45934106
Joint swelling 2822.39 11.08 6855 657688 159218 45862301
Therapeutic product effect incomplete 2770.78 11.08 4400 660143 73753 45947766
Contraindicated product administered 2259.93 11.08 4069 660474 75878 45945641
Arthralgia 2219.04 11.08 10651 653892 353952 45667567
Therapeutic product effect decreased 2184.62 11.08 4085 660458 78516 45943003
Synovitis 2098.73 11.08 3391 661152 57684 45963835
Death 2078.70 11.08 1095 663448 334453 45687066
Completed suicide 1923.10 11.08 30 664513 145890 45875629
Drug hypersensitivity 1879.34 11.08 7649 656894 236176 45785343
Liver function test increased 1386.83 11.08 1668 662875 21158 46000361
Musculoskeletal stiffness 1319.15 11.08 3711 660832 94282 45927237
Arthropathy 1004.87 11.08 3067 661476 81633 45939886
Dyspnoea 926.95 11.08 3988 660555 511560 45509959
Alopecia 926.76 11.08 4666 659877 157748 45863771
Lymphoproliferative disorder 853.79 11.08 512 664031 2180 46019339
Acute kidney injury 803.49 11.08 1325 663218 234530 45786989
Constipation 776.88 11.08 799 663744 173298 45848221
Psoriatic arthropathy 775.16 11.08 1645 662898 34734 45986785
Hypotension 763.46 11.08 1338 663205 231251 45790268
Hepatic enzyme increased 749.14 11.08 2714 661829 79073 45942446
Dehydration 708.58 11.08 735 663808 158805 45862714
C-reactive protein abnormal 706.84 11.08 1164 663379 20106 46001413
Confusional state 701.85 11.08 744 663799 159148 45862371
Drug abuse 685.91 11.08 58 664485 63350 45958169
Intentional overdose 671.76 11.08 71 664472 64873 45956646
Hyponatraemia 661.37 11.08 307 664236 101025 45920494
Infection 658.91 11.08 3688 660855 129904 45891615
Injection site pain 648.01 11.08 3131 661412 104021 45917498
Somnolence 625.66 11.08 785 663758 155736 45865783
Arthritis 599.04 11.08 2433 662110 74883 45946636
Bradycardia 576.74 11.08 120 664423 66178 45955341
Dizziness 571.23 11.08 2698 661845 337716 45683803
Cardiac arrest 569.90 11.08 287 664256 90112 45931407
Pain 567.14 11.08 9729 654814 467219 45554300
Red blood cell sedimentation rate increased 564.69 11.08 1100 663443 21789 45999730
Psoriasis 563.19 11.08 2415 662128 76189 45945330
Abdominal discomfort 547.36 11.08 3856 660687 147309 45874210
Anaemia 542.80 11.08 1847 662696 253932 45767587
Overdose 539.44 11.08 398 664145 101581 45919938
Mouth ulceration 527.84 11.08 1175 663368 25657 45995862
Anxiety 521.87 11.08 1133 663410 180824 45840695
Red blood cell sedimentation rate abnormal 515.50 11.08 792 663751 12857 46008662
Cardio-respiratory arrest 509.28 11.08 114 664429 59755 45961764
Electrocardiogram QT prolonged 508.65 11.08 65 664478 51260 45970259
Loss of personal independence in daily activities 503.57 11.08 1874 662669 55309 45966210
Tremor 482.06 11.08 561 663982 115078 45906441
Multiple sclerosis relapse 480.01 11.08 30 664513 42095 45979424
Hyperkalaemia 477.30 11.08 75 664468 50634 45970885
Injection site reaction 465.45 11.08 1620 662923 46229 45975290
Exposure during pregnancy 457.52 11.08 519 664024 107693 45913826
Joint stiffness 451.24 11.08 1112 663431 25996 45995523
Asthenia 451.00 11.08 2591 661952 308484 45713035
C-reactive protein increased 436.57 11.08 1822 662721 56768 45964751
Condition aggravated 435.15 11.08 5364 659179 239688 45781831
Decreased appetite 429.33 11.08 1373 663170 192463 45829056
Mobility decreased 421.15 11.08 1845 662698 58749 45962770
Toxicity to various agents 418.53 11.08 1575 662968 210191 45811328
Hand deformity 411.49 11.08 1254 663289 33320 45988199
Inflammation 409.90 11.08 1575 662968 47206 45974313
Hallucination 407.38 11.08 104 664439 49847 45971672
Diarrhoea 404.47 11.08 5578 658965 554024 45467495
Cardiac failure congestive 404.46 11.08 425 664118 91325 45930194
Swelling 398.52 11.08 3085 661458 121426 45900093
International normalised ratio increased 397.28 11.08 90 664453 46793 45974726
Rheumatoid factor positive 396.81 11.08 891 663652 19570 46001949
Agitation 386.81 11.08 152 664391 55263 45966256
Pancytopenia 384.28 11.08 2295 662248 82763 45938756
Drug interaction 381.78 11.08 1541 663002 201553 45819966
Systemic lupus erythematosus 381.14 11.08 1887 662656 63293 45958226
Rheumatoid nodule 380.13 11.08 551 663992 8469 46013050
Gastrointestinal disorder 378.87 11.08 1767 662776 57809 45963710
Oedema peripheral 377.28 11.08 1098 663445 158608 45862911
Hypokalaemia 375.51 11.08 419 664124 87605 45933914
Suicide attempt 374.33 11.08 157 664386 54879 45966640
Seizure 373.03 11.08 742 663801 122312 45899207
Peripheral swelling 370.73 11.08 3657 660886 154414 45867105
Foot deformity 361.99 11.08 726 663817 14699 46006820
Device expulsion 361.08 11.08 6 664537 27536 45993983
Rhabdomyolysis 348.07 11.08 84 664459 41825 45979694
Hypoglycaemia 346.30 11.08 170 664373 54179 45967340
Syncope 339.57 11.08 607 663936 104196 45917323
Bone erosion 331.67 11.08 530 664013 8913 46012606
Therapeutic response decreased 330.23 11.08 1353 663190 41792 45979727
Plasma cell myeloma 317.08 11.08 118 664425 44360 45977159
Pneumocystis jirovecii pneumonia 316.05 11.08 682 663861 14566 46006953
Lactic acidosis 312.73 11.08 53 664490 33856 45987663
Haemoglobin decreased 310.73 11.08 878 663665 128071 45893448
Depressed level of consciousness 310.41 11.08 144 664399 47425 45974094
Osteoarthritis 309.12 11.08 1718 662825 60307 45961212
Fall 305.70 11.08 3102 661441 325995 45695524
Tuberculosis 305.59 11.08 535 664008 9730 46011789
Herpes zoster 299.93 11.08 1821 662722 66051 45955468
Musculoskeletal pain 296.36 11.08 1860 662683 68268 45953251
Joint range of motion decreased 294.83 11.08 660 663883 14464 46007055
Respiratory arrest 294.47 11.08 61 664482 33755 45987764
Drug withdrawal syndrome 293.50 11.08 26 664517 27358 45994161
Product use issue 292.21 11.08 2326 662217 92318 45929201
Fluid retention 290.11 11.08 184 664359 50862 45970657
Knee arthroplasty 289.72 11.08 867 663676 22798 45998721
Injection site erythema 288.21 11.08 1931 662612 72496 45949023
Malignant neoplasm progression 286.93 11.08 300 664243 64626 45956893
Nodule 283.19 11.08 662 663881 14943 46006576
Coma 277.07 11.08 253 664290 58096 45963423
Pain in extremity 275.28 11.08 5190 659353 253490 45768029
Muscle spasms 275.19 11.08 868 663675 122245 45899274
Tachycardia 274.96 11.08 633 663910 98989 45922530
Metabolic acidosis 274.56 11.08 104 664439 38676 45982843
Diffuse large B-cell lymphoma 272.78 11.08 378 664165 5560 46015959
Acute graft versus host disease 270.43 11.08 310 664233 3720 46017799
Interstitial lung disease 269.94 11.08 1496 663047 52453 45969066
Pulmonary fibrosis 266.99 11.08 758 663785 19334 46002185
Pemphigus 262.67 11.08 1308 663235 43966 45977553
Intentional self-injury 261.57 11.08 22 664521 24144 45997375
Gastrointestinal haemorrhage 260.74 11.08 437 664106 76936 45944583
Hospitalisation 260.26 11.08 311 664232 63074 45958445
Product quality issue 256.76 11.08 93 664450 35555 45985964
Balance disorder 255.02 11.08 326 664217 64195 45957324
Injection site bruising 254.35 11.08 1094 663449 34542 45986977
Blood glucose increased 253.68 11.08 395 664148 71618 45949901
Nasopharyngitis 251.65 11.08 3321 661222 150677 45870842
Foetal exposure during pregnancy 248.81 11.08 65 664478 30682 45990837
Basal cell carcinoma 248.36 11.08 748 663795 19739 46001780
Unresponsive to stimuli 247.39 11.08 75 664468 32099 45989420
Finger deformity 246.78 11.08 335 664208 4827 46016692
Chest pain 244.73 11.08 1488 663055 174836 45846683
Sopor 242.28 11.08 9 664534 19819 46001700
Vomiting 241.31 11.08 4771 659772 448023 45573496
Cerebrovascular accident 241.12 11.08 691 663852 100348 45921171
Platelet count decreased 240.95 11.08 681 663862 99343 45922176
Renal failure 239.29 11.08 822 663721 112772 45908747
Grip strength decreased 237.55 11.08 434 664109 8172 46013347
Lower respiratory tract infection 235.14 11.08 1465 663078 53624 45967895
Product dose omission issue 234.46 11.08 1421 663122 167099 45854420
Serotonin syndrome 234.40 11.08 33 664510 24187 45997332
Sedation 229.43 11.08 28 664515 22882 45998637
Drug reaction with eosinophilia and systemic symptoms 226.97 11.08 69 664474 29479 45992040
Juvenile idiopathic arthritis 226.77 11.08 287 664256 3845 46017674
Depression 224.45 11.08 1458 663085 168646 45852873
Fear of injection 224.36 11.08 286 664257 3861 46017658
Injection site pruritus 221.96 11.08 1136 663407 38607 45982912
Loss of consciousness 220.77 11.08 794 663749 107444 45914075
Pulmonary embolism 217.87 11.08 802 663741 107783 45913736
Musculoskeletal disorder 215.92 11.08 596 663947 14949 46006570
Hypoxia 208.94 11.08 258 664285 51580 45969939
Mucosal inflammation 208.62 11.08 1101 663442 37875 45983644
Pulmonary tuberculosis 208.15 11.08 295 664248 4436 46017083
Hyperhidrosis 207.10 11.08 619 663924 88689 45932830
Chest discomfort 206.22 11.08 630 663913 89639 45931880
Suicidal ideation 203.63 11.08 304 664239 56078 45965441
Lymphoma 202.32 11.08 438 664105 9375 46012144
Epstein-Barr virus infection 201.19 11.08 353 664190 6431 46015088
Pulmonary arterial hypertension 200.14 11.08 60 664483 25868 45995651
Insomnia 193.32 11.08 1463 663080 163461 45858058
Fluid overload 190.62 11.08 74 664469 27111 45994408
Blood potassium decreased 190.44 11.08 157 664386 37906 45983613
Leukoencephalopathy 190.12 11.08 259 664284 3745 46017774
Atrial fibrillation 190.01 11.08 793 663750 102797 45918722
Injection site swelling 189.01 11.08 1099 663444 39228 45982291
Chronic graft versus host disease 188.59 11.08 213 664330 2512 46019007
Cardiac failure 188.35 11.08 550 663993 79398 45942121
Asthma 187.67 11.08 670 663873 90872 45930647
Dysgeusia 184.68 11.08 182 664361 40309 45981210
Vision blurred 183.70 11.08 554 663989 79154 45942365
Blood pressure decreased 183.31 11.08 333 664210 56826 45964693
Mental status changes 182.17 11.08 164 664379 37924 45983595
Uveitis 179.65 11.08 387 664156 8254 46013265
Skin ulcer 179.31 11.08 925 663618 31533 45989986
Abdominal pain 177.59 11.08 2259 662284 227772 45793747
Neuropathy peripheral 177.32 11.08 679 663864 90214 45931305
Tuberculin test positive 176.63 11.08 216 664327 2788 46018731
Palpitations 176.08 11.08 727 663816 94532 45926987
Myalgia 175.82 11.08 1029 663514 122059 45899460
Disorientation 175.33 11.08 160 664383 36758 45984761
Ankylosing spondylitis 173.76 11.08 330 664213 6407 46015112
Restlessness 173.23 11.08 73 664470 25451 45996068
Orthostatic hypotension 173.09 11.08 67 664476 24591 45996928
Pulmonary hypertension 172.12 11.08 155 664388 35838 45985681
Sinusitis 171.88 11.08 2698 661845 127070 45894449
Joint destruction 171.62 11.08 215 664328 2849 46018670
Anti-cyclic citrullinated peptide antibody positive 171.41 11.08 631 663912 18514 46003005
Full blood count decreased 168.56 11.08 53 664490 22158 45999361
Disease progression 168.00 11.08 698 663845 90602 45930917
Dyspnoea exertional 166.66 11.08 287 664256 50002 45971517
Flushing 166.05 11.08 426 664117 64188 45957331
Blood iron abnormal 165.81 11.08 215 664328 2955 46018564
Pulmonary oedema 164.53 11.08 297 664246 50808 45970711
Epstein-Barr virus associated lymphoproliferative disorder 163.65 11.08 149 664394 1330 46020189
Cognitive disorder 163.41 11.08 170 664373 36713 45984806
Epstein Barr virus positive mucocutaneous ulcer 162.59 11.08 76 664467 166 46021353
Lung disorder 161.28 11.08 1113 663430 42191 45979328
Breast cancer 158.50 11.08 1151 663392 44367 45977152
Stomatitis 157.84 11.08 1576 662967 66721 45954798
Aggression 157.68 11.08 63 664480 22681 45998838
Emotional distress 156.94 11.08 124 664419 30583 45990936
Lethargy 155.41 11.08 308 664235 50863 45970656
Dyskinesia 155.29 11.08 111 664432 28814 45992705
Infusion related reaction 154.26 11.08 2156 662387 99052 45922467
Withdrawal syndrome 153.23 11.08 35 664508 18099 46003420
Premature delivery 153.21 11.08 61 664482 22008 45999511
Caesarean section 152.98 11.08 26 664517 16577 46004942
Pneumonia aspiration 150.06 11.08 137 664406 31468 45990051
Joint effusion 149.21 11.08 442 664101 11553 46009966
Abnormal behaviour 148.18 11.08 57 664486 21001 46000518
Disability 147.39 11.08 396 664147 9771 46011748
Hyperglycaemia 147.24 11.08 169 664374 34902 45986617
Gastrooesophageal reflux disease 147.18 11.08 552 663991 73792 45947727
Fibromyalgia 147.10 11.08 956 663587 35507 45986012
Device dislocation 146.93 11.08 63 664480 21739 45999780
Oedema 146.90 11.08 477 664066 66594 45954925
Tenosynovitis 146.52 11.08 328 664215 7187 46014332
White blood cell count decreased 146.39 11.08 965 663578 111266 45910253
Fine motor skill dysfunction 145.78 11.08 219 664324 3481 46018038
Premature baby 143.31 11.08 40 664503 18072 46003447
Arthritis bacterial 143.06 11.08 277 664266 5459 46016060
Palmar-plantar erythrodysaesthesia syndrome 142.84 11.08 56 664487 20395 46001124
Blood creatinine increased 141.87 11.08 582 663961 75821 45945698
Delirium 141.06 11.08 194 664349 37034 45984485
Blood alkaline phosphatase increased 139.70 11.08 217 664326 39392 45982127
Hypomagnesaemia 139.15 11.08 71 664472 22139 45999380
Disseminated tuberculosis 138.28 11.08 183 664360 2569 46018950
Deep vein thrombosis 138.13 11.08 624 663919 79149 45942370
Wheezing 137.15 11.08 352 664191 53034 45968485
Malignant melanoma 135.86 11.08 386 664157 9848 46011671
Hallucination, visual 135 11.08 43 664500 17830 46003689
Disturbance in attention 134.77 11.08 150 664393 31410 45990109
Injury 133.70 11.08 265 664278 43762 45977757
Dysphagia 133.11 11.08 606 663937 76706 45944813
Pulmonary toxicity 132.49 11.08 239 664304 4454 46017065
Pregnancy 130.79 11.08 116 664427 27021 45994498
Neuroleptic malignant syndrome 129.50 11.08 7 664536 11115 46010404
Adverse reaction 129.47 11.08 327 664216 7763 46013756
B-cell lymphoma 128.40 11.08 194 664349 3100 46018419
Pulmonary mass 128.00 11.08 549 663994 17308 46004211
Angiocentric lymphoma 127.85 11.08 81 664462 388 46021131
Deformity 127.47 11.08 304 664239 6953 46014566
Acute graft versus host disease in skin 126.87 11.08 183 664360 2799 46018720
Injection site warmth 126.74 11.08 458 664085 13314 46008205
Psychotic disorder 126.51 11.08 83 664460 22538 45998981
Blood urea increased 126.29 11.08 105 664438 25247 45996272
Diabetic ketoacidosis 125.32 11.08 51 664492 18159 46003360
Epistaxis 124.99 11.08 481 664062 63824 45957695
Poisoning 124.43 11.08 24 664519 13970 46007549
Pustular psoriasis 124.31 11.08 213 664330 3804 46017715
Glossodynia 124.21 11.08 1067 663476 43306 45978213
Sinus bradycardia 123.90 11.08 23 664520 13759 46007760
Coronary artery disease 123.79 11.08 180 664363 33572 45987947
Lupus-like syndrome 122.36 11.08 314 664229 7530 46013989
Hip arthroplasty 121.59 11.08 546 663997 17566 46003953
Torsade de pointes 121.34 11.08 15 664528 12139 46009380
Impaired work ability 121.22 11.08 426 664117 12210 46009309
Ventricular tachycardia 120.93 11.08 45 664498 16922 46004597
Heart rate increased 120.71 11.08 600 663943 74191 45947328
Myocardial infarction 120.51 11.08 852 663691 96676 45924843
Febrile bone marrow aplasia 120.04 11.08 287 664256 6575 46014944
Arrhythmia 119.92 11.08 194 664349 34647 45986872
Product use in unapproved indication 119.88 11.08 1878 662665 88395 45933124
Neutrophil count decreased 119.69 11.08 276 664267 43150 45978369
Osteoporosis 118.71 11.08 986 663557 39622 45981897
Right ventricular failure 117.56 11.08 41 664502 16052 46005467
Respiratory depression 116.59 11.08 14 664529 11586 46009933
Rheumatoid lung 116.15 11.08 132 664411 1568 46019951
Histoplasmosis disseminated 114.41 11.08 108 664435 1014 46020505
Blood creatine phosphokinase increased 113.80 11.08 136 664407 27588 45993931
Irritability 113.57 11.08 147 664396 28799 45992720
Haemophagocytic lymphohistiocytosis 113.05 11.08 317 664226 8025 46013494
Arthrodesis 112.91 11.08 150 664393 2114 46019405
Intentional product misuse 112.59 11.08 322 664221 46806 45974713
Diverticulitis 110.76 11.08 828 663715 32211 45989308
Dactylitis 110.64 11.08 109 664434 1084 46020435
Angioedema 110.08 11.08 248 664295 39094 45982425
Chronic kidney disease 108.46 11.08 265 664278 40606 45980913
Hypocalcaemia 108.24 11.08 133 664410 26652 45994867
Panniculitis 107.91 11.08 246 664297 5458 46016061
Urinary retention 107.87 11.08 127 664416 25934 45995585
Extrapyramidal disorder 107.53 11.08 16 664527 11252 46010267
Contraindication to medical treatment 107.16 11.08 80 664463 523 46020996
Nightmare 107.10 11.08 51 664492 16547 46004972
Lymphocyte count decreased 106.67 11.08 124 664419 25465 45996054
Pruritus 106.14 11.08 2632 661911 239720 45781799
Circulatory collapse 105.95 11.08 91 664452 21533 45999986
Abortion spontaneous 105.89 11.08 296 664247 43350 45978169
Myoclonus 105.82 11.08 36 664507 14316 46007203
Melaena 104.93 11.08 145 664398 27627 45993892
Blood sodium decreased 104.54 11.08 93 664450 21633 45999886
Rash maculo-papular 103.86 11.08 147 664396 27727 45993792
Shoulder arthroplasty 103.10 11.08 170 664373 2938 46018581
Adverse drug reaction 103.10 11.08 1025 663518 43337 45978182
Dysarthria 102.79 11.08 239 664304 37259 45984260
Anhedonia 102.58 11.08 13 664530 10322 46011197
Acute myocardial infarction 102.32 11.08 186 664357 31738 45989781
Speech disorder 102.00 11.08 227 664316 35940 45985579
Mycobacterium tuberculosis complex test positive 101.88 11.08 119 664424 1459 46020060
Acute respiratory failure 101.45 11.08 161 664382 28977 45992542
Dystonia 100.74 11.08 19 664524 11238 46010281
Impaired healing 99.95 11.08 878 663665 35865 45985654
Demyelination 99.83 11.08 238 664305 5442 46016077
Immunosuppression 99.67 11.08 283 664260 7217 46014302
Venoocclusive liver disease 99.63 11.08 200 664343 4051 46017468
Polyarthritis 99.08 11.08 259 664284 6283 46015236
Memory impairment 98.79 11.08 669 663874 76668 45944851
Drug clearance decreased 98.60 11.08 98 664445 986 46020533
Oral herpes 98.48 11.08 540 664003 18850 46002669
Latent tuberculosis 96.43 11.08 129 664414 1831 46019688
Transfusion 96.15 11.08 34 664509 13197 46008322
Joint arthroplasty 96.06 11.08 131 664412 1896 46019623
Blood bilirubin increased 96.03 11.08 215 664328 33969 45987550
Graft versus host disease 95.90 11.08 257 664286 6331 46015188
Mania 95.59 11.08 19 664524 10827 46010692
Cholecystitis chronic 95.51 11.08 17 664526 10482 46011037
Paraesthesia 94.72 11.08 1142 663401 116295 45905224
Upper gastrointestinal haemorrhage 94.17 11.08 61 664482 16677 46004842
Bone marrow failure 94.11 11.08 734 663809 28935 45992584
Peritonitis bacterial 93.31 11.08 8 664535 8645 46012874
Sensitivity to weather change 92.53 11.08 227 664316 5289 46016230
Jaundice 92.50 11.08 168 664375 28677 45992842
Deafness transitory 92.18 11.08 115 664428 1517 46020002
Blood glucose decreased 91.95 11.08 80 664463 18812 46002707
Tubulointerstitial nephritis 91.56 11.08 48 664495 14740 46006779
Foot operation 91.51 11.08 206 664337 4531 46016988
Sinus tachycardia 91.22 11.08 104 664439 21545 45999974
Cardiac disorder 91.18 11.08 319 664224 43539 45977980
Thrombocytopenia 89.92 11.08 1264 663279 125317 45896202
Thrombosis 89.21 11.08 452 664091 55617 45965902
Hypothermia 89.06 11.08 31 664512 12152 46009367
X-ray abnormal 88.88 11.08 97 664446 1098 46020421
Muscle twitching 88.83 11.08 49 664494 14623 46006896
Immobile 87.52 11.08 199 664344 4407 46017112
Altered state of consciousness 87.12 11.08 123 664420 23225 45998294
Haemorrhage 86.91 11.08 443 664100 54426 45967093
Abdominal distension 86.63 11.08 649 663894 72702 45948817
Injection site haemorrhage 86.62 11.08 548 663995 20161 46001358
Bone pain 86.51 11.08 358 664185 46532 45974987
Premature labour 85.66 11.08 27 664516 11272 46010247
Neoplasm progression 85.04 11.08 156 664387 26527 45994992
Electrolyte imbalance 84.99 11.08 72 664471 17154 46004365
Schizophrenia 84.51 11.08 11 664532 8557 46012962
Presyncope 84.31 11.08 136 664407 24318 45997201
Chronic obstructive pulmonary disease 84.27 11.08 478 664065 57155 45964364
Akathisia 83.54 11.08 7 664536 7707 46013812
Hodgkin's disease 83.37 11.08 80 664463 768 46020751
Blood calcium decreased 83.01 11.08 61 664482 15612 46005907
Delusion 82.59 11.08 28 664515 11160 46010359
Product substitution issue 81.58 11.08 57 664486 14974 46006545
Cardiogenic shock 81.43 11.08 68 664475 16316 46005203
Parkinsonism 81.36 11.08 9 664534 7939 46013580
Head injury 81.24 11.08 141 664402 24495 45997024
Localised infection 80.63 11.08 598 663945 23203 45998316
Elbow deformity 80.19 11.08 98 664445 1264 46020255
Flatulence 80.01 11.08 183 664360 28695 45992824
Haematocrit decreased 79.07 11.08 246 664297 34811 45986708
Limb deformity 77.62 11.08 163 664380 3413 46018106
Mucosal ulceration 77.45 11.08 79 664464 822 46020697
Stevens-Johnson syndrome 77.13 11.08 133 664410 23164 45998355
Wound 76.96 11.08 940 663603 41862 45979657
Synovial cyst 76.90 11.08 255 664288 7091 46014428
Therapy non-responder 75.40 11.08 907 663636 40245 45981274
Muscle rigidity 75.17 11.08 24 664519 9937 46011582
Breast cancer stage III 74.99 11.08 95 664448 1274 46020245
Pericarditis 74.81 11.08 590 663953 23337 45998182
Mental disorder 74.27 11.08 128 664415 22297 45999222
Swollen tongue 74.10 11.08 194 664349 29038 45992481
Musculoskeletal deformity 74.10 11.08 73 664470 726 46020793
Paranoia 74.03 11.08 29 664514 10568 46010951
Dry skin 73.90 11.08 316 664227 40700 45980819
Status epilepticus 73.27 11.08 55 664488 13924 46007595
Hypofibrinogenaemia 72.96 11.08 83 664460 987 46020532
Hepatotoxicity 72.95 11.08 607 663936 24402 45997117
Urinary incontinence 72.58 11.08 189 664354 28341 45993178
Complication associated with device 72.03 11.08 68 664475 15373 46006146
Abnormal dreams 72.03 11.08 28 664515 10251 46011268
Spinal stenosis 71.73 11.08 361 664182 12182 46009337
Tardive dyskinesia 71.31 11.08 11 664532 7532 46013987
Joint dislocation 71.21 11.08 332 664211 10854 46010665
Hallucination, auditory 71.02 11.08 32 664511 10724 46010795
Pharyngitis 70.90 11.08 461 664082 17122 46004397
Urinary tract infection 70.90 11.08 2494 662049 217772 45803747
Histoplasmosis 70.86 11.08 103 664440 1587 46019932
Hypersensitivity 70.74 11.08 2712 661831 147609 45873910
Lip swelling 70.29 11.08 161 664382 25234 45996285
Uterine perforation 70.08 11.08 10 664533 7257 46014262
Cerebral haemorrhage 69.86 11.08 191 664352 28180 45993339
Off label use 69.40 11.08 6292 658251 373549 45647970
Respiratory failure 69.39 11.08 941 663602 93875 45927644
Chills 69.23 11.08 956 663587 95076 45926443
Feeling abnormal 69.19 11.08 1308 663235 123752 45897767
Pneumonitis 69.13 11.08 663 663880 27757 45993762
Haematemesis 68.66 11.08 197 664346 28609 45992910
Skin cancer 68.51 11.08 278 664265 8545 46012974
Ulcer 68.31 11.08 453 664090 16939 46004580
Aphthous ulcer 68.01 11.08 293 664250 9255 46012264
Retinal toxicity 67.75 11.08 80 664463 993 46020526
Bronchitis chronic 67.28 11.08 169 664374 3998 46017521
Granuloma skin 67.14 11.08 151 664392 3319 46018200
Blood count abnormal 66.88 11.08 94 664449 17784 46003735
Red blood cell count decreased 66.66 11.08 239 664304 32384 45989135
Respiratory distress 66.43 11.08 232 664311 31684 45989835
Drug tolerance decreased 65.89 11.08 139 664404 2920 46018599
Injection site rash 65.86 11.08 418 664125 15395 46006124
Myelopathy 65.81 11.08 125 664418 2427 46019092
Ventricular extrasystoles 65.46 11.08 38 664505 11025 46010494
Infusion site pain 65.29 11.08 31 664512 10076 46011443
Atrial septal defect 65.25 11.08 7 664536 6325 46015194
Hypertension 65.09 11.08 2215 662328 194141 45827378
Leukocytosis 65.04 11.08 148 664395 23250 45998269
Electrocardiogram QRS complex prolonged 64.81 11.08 3 664540 5446 46016073
Haematoma 64.79 11.08 234 664309 31638 45989881
Blood magnesium decreased 64.70 11.08 38 664505 10954 46010565
Sleep disorder 64.57 11.08 980 663563 45815 45975704
Epilepsy 64.49 11.08 152 664391 23586 45997933
Atrioventricular block 64.24 11.08 10 664533 6801 46014718
Neutropenia 64.02 11.08 1550 662993 141654 45879865
Injection site urticaria 63.97 11.08 338 664205 11629 46009890
Oxygen saturation decreased 63.90 11.08 652 663891 68512 45953007
Fear 63.57 11.08 82 664461 16090 46005429
Acute lymphocytic leukaemia recurrent 63.41 11.08 110 664433 1985 46019534
Tricuspid valve incompetence 63.30 11.08 61 664482 13656 46007863
Joint injury 63.02 11.08 479 664064 18730 46002789
Hospice care 62.70 11.08 3 664540 5292 46016227
Lymph node tuberculosis 62.61 11.08 66 664477 716 46020803
Gamma-glutamyltransferase increased 62.57 11.08 236 664307 31504 45990015
Enthesopathy 62.35 11.08 177 664366 4513 46017006
Epidermal necrosis 62.22 11.08 68 664475 771 46020748
Product administration error 61.89 11.08 116 664427 19565 46001954
Cyanosis 61.74 11.08 82 664461 15889 46005630
Acute hepatic failure 61.72 11.08 71 664472 14650 46006869
Mucocutaneous ulceration 61.71 11.08 35 664508 131 46021388
Depressed mood 61.70 11.08 254 664289 33065 45988454
Product complaint 61.66 11.08 49 664494 12052 46009467
Transient ischaemic attack 61.60 11.08 271 664272 34632 45986887
Ear infection 61.59 11.08 548 663995 22465 45999054
Body height below normal 61.56 11.08 101 664442 1738 46019781
Atrioventricular block first degree 60.87 11.08 8 664535 6178 46015341
Eosinophilia 60.66 11.08 113 664430 19104 46002415
Dementia 60.47 11.08 74 664469 14856 46006663
Obstructive airways disorder 60.33 11.08 61 664482 13351 46008168
Generalised tonic-clonic seizure 59.98 11.08 192 664351 26930 45994589
Neck pain 59.73 11.08 1113 663430 54193 45967326
Pleural effusion 59.71 11.08 826 663717 82126 45939393
No adverse event 59.68 11.08 267 664276 33964 45987555
Hepatic steatosis 59.53 11.08 563 663980 23479 45998040
Dialysis 59.50 11.08 35 664508 10081 46011438
Rheumatoid factor negative 59.46 11.08 55 664488 502 46021017
Investigation abnormal 59.32 11.08 74 664469 976 46020543
Renal injury 59.02 11.08 31 664512 9510 46012009
Rectal haemorrhage 58.81 11.08 312 664231 37943 45983576
Epicondylitis 58.75 11.08 96 664447 1646 46019873
Nervousness 58.59 11.08 208 664335 28267 45993252
Diabetes mellitus inadequate control 58.42 11.08 61 664482 13153 46008366
Infusion site erythema 58.40 11.08 18 664525 7624 46013895
Face oedema 58.38 11.08 115 664428 19038 46002481
Haemoptysis 58.19 11.08 185 664358 26004 45995515
Tonsillitis 58.05 11.08 179 664364 4785 46016734
Rash 57.31 11.08 5853 658690 350659 45670860
Chromaturia 57.15 11.08 78 664465 14941 46006578
Liver function test abnormal 57.15 11.08 955 663588 45532 45975987
Wrist deformity 56.93 11.08 88 664455 1436 46020083
Neuroendocrine carcinoma of the skin 56.73 11.08 49 664494 405 46021114
Treatment noncompliance 56.72 11.08 224 664319 29507 45992012
Onychomycosis 56.69 11.08 158 664385 3985 46017534
Sarcoidosis 56.63 11.08 182 664361 4977 46016542
Ascites 56.45 11.08 298 664245 36286 45985233
Pallor 56.27 11.08 157 664386 23009 45998510
Somnambulism 56.16 11.08 4 664539 5033 46016486
Acute generalised exanthematous pustulosis 56.08 11.08 32 664511 9373 46012146
Mydriasis 55.99 11.08 41 664502 10512 46011007
General physical health deterioration 55.95 11.08 1238 663305 114531 45906988
Hepatic encephalopathy 55.81 11.08 38 664505 10119 46011400
Seronegative arthritis 55.73 11.08 61 664482 693 46020826
Scleritis 55.54 11.08 126 664417 2786 46018733
Transplant rejection 55.32 11.08 34 664509 9562 46011957
Wrist surgery 55.22 11.08 62 664481 726 46020793
Gestational diabetes 55.18 11.08 17 664526 7202 46014317
Complication of device insertion 54.91 11.08 4 664539 4940 46016579
Eye disorder 54.90 11.08 444 664099 17697 46003822
Product physical issue 54.68 11.08 4 664539 4923 46016596
Aspartate aminotransferase increased 54.40 11.08 790 663753 77910 45943609
Joint noise 54.36 11.08 132 664411 3055 46018464
Ankle deformity 54.32 11.08 46 664497 369 46021150
Pneumonia legionella 53.98 11.08 81 664462 1286 46020233
SLE arthritis 53.94 11.08 55 664488 572 46020947
Acute graft versus host disease in intestine 53.94 11.08 91 664452 1604 46019915
Inflammatory marker increased 53.74 11.08 186 664357 5289 46016230
Incorrect product administration duration 53.74 11.08 35 664508 9542 46011977
Mood altered 53.17 11.08 64 664479 12943 46008576
Tinnitus 53.11 11.08 208 664335 27465 45994054
Swelling face 52.88 11.08 491 664052 52568 45968951
Drug dependence 52.82 11.08 129 664414 19772 46001747
Atypical mycobacterial infection 52.80 11.08 65 664478 845 46020674
Pulseless electrical activity 52.80 11.08 18 664525 7149 46014370
Retching 52.58 11.08 65 664478 12992 46008527
Anuria 52.55 11.08 51 664492 11380 46010139
Visceral leishmaniasis 52.54 11.08 47 664496 409 46021110
Epstein-Barr virus associated lymphoma 52.48 11.08 39 664504 253 46021266
Pre-eclampsia 52.44 11.08 24 664519 7970 46013549
Acidosis 52.37 11.08 49 664494 11125 46010394
Blood parathyroid hormone decreased 52.19 11.08 159 664384 4222 46017297
Stillbirth 51.98 11.08 14 664529 6477 46015042
Unevaluable event 51.95 11.08 414 664129 45761 45975758
Blood pressure fluctuation 51.86 11.08 662 663881 29786 45991733
Renal tubular necrosis 51.83 11.08 46 664497 10713 46010806
Forced expiratory volume decreased 51.69 11.08 6 664537 5098 46016421
Creatinine renal clearance decreased 51.64 11.08 17 664526 6903 46014616
Non-Hodgkin's lymphoma 51.55 11.08 85 664458 1469 46020050
Psychomotor hyperactivity 51.45 11.08 37 664506 9576 46011943
Pollakiuria 51.41 11.08 175 664368 24086 45997433
Transaminases increased 51.35 11.08 613 663930 27148 45994371
Wrong technique in product usage process 51.11 11.08 511 664032 53911 45967608
Dysuria 51.02 11.08 213 664330 27620 45993899
Inappropriate antidiuretic hormone secretion 50.93 11.08 76 664467 14026 46007493
Osteonecrosis of jaw 50.46 11.08 285 664258 34117 45987402
Graft versus host disease in skin 50.34 11.08 107 664436 2260 46019259
Lip ulceration 50.24 11.08 89 664454 1634 46019885
Foetal methotrexate syndrome 50.20 11.08 23 664520 47 46021472
Bronchitis 50.06 11.08 1913 662630 104066 45917453
Hot flush 49.97 11.08 388 664155 43129 45978390
Sleep apnoea syndrome 49.91 11.08 156 664387 22045 45999474
Pleurisy 49.87 11.08 231 664312 7531 46013988
Lennox-Gastaut syndrome 49.79 11.08 37 664506 240 46021279
Ventricular fibrillation 49.78 11.08 54 664489 11442 46010077
Ageusia 49.55 11.08 54 664489 11418 46010101
Skin necrosis 49.46 11.08 248 664295 8356 46013163
Ejection fraction decreased 49.42 11.08 114 664429 17823 46003696
Supraventricular tachycardia 49.41 11.08 70 664473 13200 46008319
Pregnancy with contraceptive device 49.00 11.08 4 664539 4499 46017020
Lung adenocarcinoma 48.61 11.08 151 664392 4053 46017466
Synovectomy 48.54 11.08 31 664512 151 46021368
Hepatosplenic T-cell lymphoma 48.50 11.08 52 664491 576 46020943
Hypothyroidism 48.50 11.08 255 664288 31083 45990436
Thinking abnormal 48.44 11.08 41 664502 9773 46011746
Blood loss anaemia 48.39 11.08 31 664512 8526 46012993
Toxic epidermal necrolysis 48.37 11.08 159 664384 22119 45999400
Surgical failure 47.97 11.08 64 664479 906 46020613
Neurotoxicity 47.81 11.08 347 664196 13370 46008149
Hyperlipidaemia 47.78 11.08 122 664421 18417 46003102
Rheumatoid factor increased 47.75 11.08 77 664466 1305 46020214
Haemorrhage intracranial 47.50 11.08 67 664476 12657 46008862
Blood potassium increased 47.42 11.08 107 664436 16860 46004659
Shock 47.36 11.08 156 664387 21689 45999830
Rheumatic disorder 47.22 11.08 78 664465 1350 46020169
Device breakage 47.22 11.08 41 664502 9651 46011868
Chronic graft versus host disease in skin 47.16 11.08 51 664492 571 46020948
Bradyphrenia 47.03 11.08 15 664528 6215 46015304
Spinal column injury 46.99 11.08 89 664454 1724 46019795
Mycobacterium marinum infection 46.84 11.08 27 664516 105 46021414
Hepatic fibrosis 46.82 11.08 120 664423 2875 46018644
Hypovolaemia 46.77 11.08 43 664500 9845 46011674
Device use error 46.71 11.08 8 664535 5073 46016446
Heparin-induced thrombocytopenia 46.42 11.08 4 664539 4305 46017214
Infusion site swelling 46.19 11.08 12 664531 5687 46015832
Respiratory acidosis 46.06 11.08 15 664528 6133 46015386
Sciatica 45.90 11.08 443 664100 18577 46002942
Hepatitis E 45.52 11.08 71 664472 1168 46020351
Ovarian neoplasm 45.51 11.08 57 664486 755 46020764
Dermatitis allergic 45.18 11.08 321 664222 12282 46009237
Temporal lobe epilepsy 45.17 11.08 40 664503 343 46021176
Dislocation of vertebra 45.15 11.08 73 664470 1240 46020279
Glycosylated haemoglobin increased 45.01 11.08 53 664490 10823 46010696
Oral mucosal exfoliation 45.00 11.08 80 664463 1473 46020046
Multiple sclerosis 44.66 11.08 191 664352 24600 45996919
Metabolic encephalopathy 44.52 11.08 11 664532 5392 46016127
Salivary hypersecretion 44.43 11.08 18 664525 6427 46015092
Nasal ulcer 44.09 11.08 76 664467 1364 46020155
Liver disorder 43.90 11.08 760 663783 36486 45985033
Adenovirus infection 43.84 11.08 113 664430 2717 46018802
Anger 43.66 11.08 63 664480 11789 46009730
Cytokine release syndrome 43.52 11.08 17 664526 6206 46015313
Transaminases abnormal 43.50 11.08 46 664497 501 46021018
Amyotrophic lateral sclerosis 43.43 11.08 64 664479 999 46020520
Eye swelling 43.28 11.08 144 664399 19959 46001560
Varicella zoster virus infection 43.16 11.08 100 664443 2243 46019276
Hypercapnia 43.16 11.08 7 664536 4619 46016900
Cutaneous vasculitis 43.09 11.08 140 664403 3851 46017668
Skin erosion 43.03 11.08 99 664444 2210 46019309
Pneumonia cryptococcal 43 11.08 47 664496 533 46020986
Gastrointestinal pain 42.94 11.08 215 664328 7240 46014279
Renal impairment 42.94 11.08 772 663771 73600 45947919
Organising pneumonia 42.56 11.08 160 664383 4742 46016777
Atrioventricular block second degree 42.40 11.08 3 664540 3796 46017723
Encephalitis 42.33 11.08 214 664329 7234 46014285
Ill-defined disorder 42.24 11.08 575 663968 26252 45995267
Panic attack 42.22 11.08 147 664396 20095 46001424
Vascular access complication 42.15 11.08 60 664483 906 46020613
Glaucoma 42.03 11.08 378 664165 15543 46005976
Bradykinesia 41.87 11.08 4 664539 3962 46017557
Human antichimeric antibody positive 41.86 11.08 73 664470 1323 46020196
Malignant respiratory tract neoplasm 41.82 11.08 20 664523 47 46021472
Muscle tightness 41.81 11.08 51 664492 10254 46011265
Pyrexia 41.66 11.08 4338 660205 344464 45677055
Erythema multiforme 41.56 11.08 46 664497 9658 46011861
Coordination abnormal 41.53 11.08 57 664486 10892 46010627
Spondyloarthropathy 41.25 11.08 50 664493 639 46020880
Hypophosphataemia 41.23 11.08 27 664516 7340 46014179
Genital haemorrhage 41.11 11.08 21 664522 6545 46014974
Hypoaesthesia oral 41.03 11.08 54 664489 10505 46011014
Drug screen positive 40.88 11.08 4 664539 3887 46017632
Complications of bone marrow transplant 40.84 11.08 41 664502 418 46021101
Ankle arthroplasty 40.75 11.08 47 664496 568 46020951
Tenderness 40.65 11.08 393 664150 16488 46005031
Lung neoplasm malignant 40.51 11.08 367 664176 15122 46006397
Muscular weakness 40.50 11.08 996 663547 90848 45930671
Vertigo 40.47 11.08 510 664033 51538 45969981
Secretion discharge 40.46 11.08 247 664296 8972 46012547
Cholestasis 40.42 11.08 221 664322 26672 45994847
Headache 40.11 11.08 6087 658456 472265 45549254
Device difficult to use 40.05 11.08 33 664510 7971 46013548
Urine output decreased 39.89 11.08 60 664483 11037 46010482
Leukopenia 39.85 11.08 1264 663279 67079 45954440
Prothrombin time prolonged 39.46 11.08 47 664496 9549 46011970
Joint laxity 39.21 11.08 90 664453 2006 46019513
Blood pressure systolic abnormal 39.06 11.08 169 664374 5348 46016171
Foetal death 39.06 11.08 40 664503 8703 46012816
Hyperreflexia 39.04 11.08 13 664530 5241 46016278
Tachypnoea 38.90 11.08 92 664451 14259 46007260
Hereditary angioedema 38.69 11.08 15 664528 5501 46016018
Extranodal marginal zone B-cell lymphoma (MALT type) 38.65 11.08 40 664503 424 46021095
Cholelithiasis 38.52 11.08 358 664185 38323 45983196
Application site erythema 38.48 11.08 11 664532 4893 46016626
Dizziness postural 38.34 11.08 22 664521 6424 46015095
Physical disability 38.32 11.08 83 664460 1777 46019742
Lower gastrointestinal haemorrhage 38.11 11.08 29 664514 7291 46014228
Thyroid neoplasm 38.08 11.08 127 664416 3542 46017977
Blood pressure diastolic abnormal 38.02 11.08 184 664359 6110 46015409
Peritoneal tuberculosis 37.88 11.08 43 664500 510 46021009
Acute coronary syndrome 37.82 11.08 54 664489 10150 46011369
Aspiration 37.80 11.08 48 664495 9483 46012036
Cardiomegaly 37.79 11.08 125 664418 17357 46004162
Low birth weight baby 37.75 11.08 15 664528 5419 46016100
Graft versus host disease in gastrointestinal tract 37.64 11.08 100 664443 2450 46019069
Alveolitis 37.56 11.08 99 664444 2414 46019105
Faecaloma 37.52 11.08 33 664510 7719 46013800
Atrioventricular block complete 37.48 11.08 32 664511 7595 46013924
Neutrophil count increased 37.35 11.08 93 664450 14160 46007359
Iritis 37.33 11.08 95 664448 2266 46019253
Posterior reversible encephalopathy syndrome 37.20 11.08 354 664189 14787 46006732
Unintended pregnancy 37.12 11.08 17 664526 5643 46015876
Maternal drugs affecting foetus 37.09 11.08 16 664527 5502 46016017
Hypersensitivity pneumonitis 37.02 11.08 95 664448 2278 46019241
Epstein-Barr viraemia 37.02 11.08 49 664494 688 46020831
Faeces discoloured 37.00 11.08 119 664424 16668 46004851
Central nervous system lymphoma 36.86 11.08 65 664478 1189 46020330
Skin exfoliation 36.74 11.08 296 664247 32642 45988877
Catatonia 36.70 11.08 5 664538 3757 46017762
Viral upper respiratory tract infection 36.68 11.08 197 664346 6821 46014698
Mitral valve incompetence 36.62 11.08 141 664402 18711 46002808
Amnesia 36.59 11.08 397 664146 41234 45980285
Arthritis infective 36.49 11.08 157 664386 4956 46016563
Paraesthesia oral 36.48 11.08 70 664473 11703 46009816
Atrial flutter 36.36 11.08 46 664497 9102 46012417
Synovial disorder 36.30 11.08 52 664491 790 46020729
Subdural haematoma 36.29 11.08 82 664461 12915 46008604
Hip fracture 36.29 11.08 225 664318 26331 45995188
Mental impairment 36.09 11.08 77 664466 12379 46009140
Pneumonia viral 36.03 11.08 188 664355 6436 46015083
Haematuria 35.96 11.08 229 664314 26629 45994890
Oropharyngeal pain 35.78 11.08 1342 663201 72826 45948693
Product preparation error 35.75 11.08 7 664536 4032 46017487
Metastases to bone 35.72 11.08 128 664415 17348 46004171
Patent ductus arteriosus 35.68 11.08 6 664537 3856 46017663
Synostosis 35.53 11.08 17 664526 40 46021479
Abortion incomplete 35.24 11.08 3 664540 3261 46018258
Adult T-cell lymphoma/leukaemia 35.02 11.08 33 664510 309 46021210
Squamous cell carcinoma of lung 34.98 11.08 51 664492 788 46020731
Weight increased 34.97 11.08 1949 662594 162524 45858995
Joint space narrowing 34.95 11.08 23 664520 119 46021400
Ulcerative keratitis 34.95 11.08 91 664452 2202 46019317
Cold sweat 34.86 11.08 64 664479 10881 46010638
White blood cell count increased 34.48 11.08 433 664110 43786 45977733
Disability assessment scale score increased 34.45 11.08 89 664454 2143 46019376
Hepatic cirrhosis 34.39 11.08 359 664184 15373 46006146
Blood pressure inadequately controlled 34.36 11.08 10 664533 4396 46017123
Hepatic enzyme abnormal 34.28 11.08 136 664407 4136 46017383
Mycobacterium chelonae infection 34.23 11.08 37 664506 414 46021105
Clonus 34.22 11.08 8 664535 4072 46017447
Non-alcoholic steatohepatitis 34.19 11.08 69 664474 1403 46020116
Hypotonia 34.16 11.08 40 664503 8189 46013330
Hepatitis B reactivation 34.02 11.08 70 664473 1444 46020075
Dry mouth 34.00 11.08 563 663980 54363 45967156
Bronchial carcinoma 33.99 11.08 45 664498 632 46020887
Bone swelling 33.98 11.08 62 664481 1166 46020353
Pancreatitis acute 33.85 11.08 211 664332 24661 45996858
Hypernatraemia 33.79 11.08 25 664518 6376 46015143
Disease recurrence 33.78 11.08 407 664136 18064 46003455
Carpal tunnel syndrome 33.77 11.08 360 664183 15499 46006020
Colon cancer 33.76 11.08 237 664306 9032 46012487
Infusion site pruritus 33.57 11.08 3 664540 3135 46018384
Troponin increased 33.53 11.08 37 664506 7779 46013740
Pharyngitis streptococcal 33.52 11.08 221 664322 8247 46013272
Hyperthyroidism 33.43 11.08 73 664470 11638 46009881
Skin plaque 33.41 11.08 168 664375 5667 46015852
Pre-existing condition improved 33.41 11.08 27 664516 6585 46014934
Application site pruritus 33.40 11.08 8 664535 4005 46017514
Tonsillar ulcer 33.36 11.08 29 664514 242 46021277
Pulmonary sarcoidosis 33.22 11.08 51 664492 827 46020692
C-reactive protein decreased 33.06 11.08 45 664498 650 46020869
Catheter site erythema 33.03 11.08 8 664535 3975 46017544
Cerebral toxoplasmosis 33.02 11.08 46 664497 680 46020839
Sacroiliitis 32.98 11.08 86 664457 2083 46019436
Osteoporotic fracture 32.97 11.08 106 664437 2899 46018620
Neoplasm recurrence 32.97 11.08 91 664452 2282 46019237
Nonalcoholic fatty liver disease 32.95 11.08 48 664495 741 46020778
Foetal growth restriction 32.95 11.08 27 664516 6540 46014979
Aspiration bone marrow abnormal 32.94 11.08 15 664528 30 46021489
Small for dates baby 32.84 11.08 6 664537 3631 46017888
Oliguria 32.82 11.08 46 664497 8713 46012806
Aphasia 32.65 11.08 255 664288 28312 45993207
Joint warmth 32.60 11.08 62 664481 1205 46020314
Electrocardiogram abnormal 32.57 11.08 31 664512 6981 46014538
Cataract 32.53 11.08 862 663681 44553 45976966
Angina pectoris 32.51 11.08 235 664308 26540 45994979
Colitis ischaemic 32.49 11.08 59 664484 10073 46011446
Limb operation 32.42 11.08 113 664430 3225 46018294
Leukaemia recurrent 32.38 11.08 63 664480 1246 46020273
End stage renal disease 32.37 11.08 22 664521 5864 46015655
Mucosal toxicity 32.28 11.08 31 664512 298 46021221
Diplopia 32.26 11.08 154 664389 19251 46002268
Normal newborn 32.25 11.08 23 664520 5978 46015541
Ileus 32.20 11.08 98 664445 13966 46007553
Helicobacter infection 32.20 11.08 281 664262 11455 46010064
Blood prolactin increased 32.10 11.08 3 664540 3024 46018495
Intestinal obstruction 32.07 11.08 228 664315 25847 45995672
Underdose 32.05 11.08 156 664387 19402 46002117
Haemodialysis 32.01 11.08 51 664492 9166 46012353
Vaginal haemorrhage 31.93 11.08 223 664320 25381 45996138
Rheumatic fever 31.85 11.08 101 664442 2742 46018777
Haemolytic anaemia 31.84 11.08 57 664486 9785 46011734
Product residue present 31.80 11.08 8 664535 3874 46017645
Ventricular septal defect 31.74 11.08 9 664534 4025 46017494
Screaming 31.70 11.08 4 664539 3187 46018332
Breast cancer female 31.58 11.08 168 664375 5795 46015724
Extrapulmonary tuberculosis 31.58 11.08 29 664514 262 46021257
Skin reaction 31.56 11.08 265 664278 10681 46010838
Anti-cyclic citrullinated peptide antibody 31.49 11.08 29 664514 263 46021256
Bronchospasm 31.47 11.08 116 664427 15591 46005928
Visual acuity reduced 31.46 11.08 185 664358 21928 45999591
Skin lesion 31.45 11.08 545 663998 26168 45995351
Diffuse large B-cell lymphoma stage IV 31.45 11.08 26 664517 201 46021318
Activated partial thromboplastin time prolonged 31.36 11.08 31 664512 6858 46014661
Tooth abscess 31.36 11.08 296 664247 12337 46009182
Aplasia pure red cell 31.09 11.08 12 664531 4413 46017106
Oxygen consumption increased 31.09 11.08 7 664536 3656 46017863
Cutaneous leishmaniasis 31.04 11.08 18 664525 71 46021448
Folliculitis 30.99 11.08 172 664371 6031 46015488
Respiratory tract infection 30.92 11.08 599 663944 29373 45992146
Glomerular filtration rate decreased 30.88 11.08 76 664467 11618 46009901
Sudden death 30.79 11.08 55 664488 9449 46012070
Prescribed overdose 30.77 11.08 64 664479 10385 46011134
Tongue neoplasm malignant stage unspecified 30.76 11.08 48 664495 790 46020729
Increased appetite 30.75 11.08 46 664497 8481 46013038
Tooth infection 30.56 11.08 288 664255 11998 46009521
Hypoxic-ischaemic encephalopathy 30.40 11.08 10 664533 4063 46017456
Choking 30.38 11.08 45 664498 8331 46013188
Bronchiectasis 30.38 11.08 232 664311 9084 46012435
Blood calcium increased 30.31 11.08 38 664505 7549 46013970
Long QT syndrome 30.27 11.08 4 664539 3076 46018443
Epstein-Barr virus antigen positive 30.12 11.08 14 664529 30 46021489
Haemorrhoids 30.07 11.08 151 664392 18626 46002893
Antibody test positive 30.05 11.08 83 664460 2082 46019437
Arteriosclerosis 30.05 11.08 58 664485 9675 46011844
Hypertonia 29.94 11.08 13 664530 4453 46017066
Psychomotor retardation 29.92 11.08 5 664538 3228 46018291
Personality change 29.80 11.08 19 664524 5239 46016280
Acute lymphocytic leukaemia 29.69 11.08 97 664446 2676 46018843
Arachnoiditis 29.57 11.08 30 664513 310 46021209
Low turnover osteopathy 29.53 11.08 12 664531 4277 46017242
Ischaemic stroke 29.41 11.08 130 664413 16592 46004927
Angioimmunoblastic T-cell lymphoma stage IV 29.40 11.08 9 664534 0 46021519
Cerebral infarction 29.38 11.08 203 664340 23163 45998356
Bundle branch block right 29.31 11.08 16 664527 4803 46016716
Hepatic failure 29.23 11.08 319 664224 33097 45988422
Pain in jaw 29.08 11.08 378 664165 37994 45983525
Choriocarcinoma 29.07 11.08 19 664524 97 46021422
Acute pulmonary histoplasmosis 29.04 11.08 20 664523 113 46021406
Pulmonary arterial pressure increased 29.03 11.08 6 664537 3326 46018193
Ketoacidosis 29.02 11.08 10 664533 3945 46017574
Dry eye 28.95 11.08 599 663944 29723 45991796
Coagulopathy 28.92 11.08 150 664393 18349 46003170
Incorrect dosage administered 28.80 11.08 70 664473 1621 46019898
Antinuclear antibody positive 28.67 11.08 170 664373 6110 46015409
Red cell distribution width decreased 28.65 11.08 48 664495 841 46020678
Viral vasculitis 28.61 11.08 15 664528 46 46021473
Bone density decreased 28.60 11.08 237 664306 9515 46012004
Keratopathy 28.46 11.08 28 664515 278 46021241
Hypoaesthesia 28.39 11.08 1392 663151 117477 45904042
Hepatitis B 28.38 11.08 116 664427 3577 46017942
Joint lock 28.36 11.08 79 664464 1992 46019527
Proteinuria 28.32 11.08 130 664413 16423 46005096
Cutaneous T-cell lymphoma 28.28 11.08 61 664482 1302 46020217
Small intestinal obstruction 28.27 11.08 126 664417 16046 46005473
Mycobacterial infection 28.24 11.08 68 664475 1565 46019954
Application site pain 28.12 11.08 11 664532 4012 46017507
Failure to thrive 28.09 11.08 32 664511 6632 46014887
Apnoea 28.04 11.08 38 664505 7301 46014218
Oligohydramnios 28.01 11.08 22 664521 5443 46016076
Leishmaniasis 27.93 11.08 13 664530 28 46021491
Blood glucose fluctuation 27.90 11.08 12 664531 4134 46017385
Post procedural infection 27.90 11.08 193 664350 7320 46014199
Toxic skin eruption 27.87 11.08 87 664456 12300 46009219
Injection site irritation 27.85 11.08 128 664415 4159 46017360
Pericardial effusion 27.82 11.08 231 664312 25312 45996207
Clostridium difficile infection 27.80 11.08 226 664317 24877 45996642
Polyuria 27.75 11.08 37 664506 7158 46014361
Pancreatitis 27.72 11.08 445 664098 43182 45978337
Incontinence 27.72 11.08 62 664481 9800 46011719
Encephalopathy 27.67 11.08 325 664218 33264 45988255
Ophthalmic herpes zoster 27.63 11.08 65 664478 1473 46020046
Injection site haematoma 27.61 11.08 165 664378 5947 46015572
Eyelid oedema 27.59 11.08 67 664476 10290 46011229
Hypophagia 27.58 11.08 275 664268 29031 45992488
Injection site inflammation 27.56 11.08 102 664441 3000 46018519
Brain natriuretic peptide increased 27.47 11.08 16 664527 4634 46016885
Carcinoma in situ of skin 27.45 11.08 24 664519 202 46021317
Gait disturbance 27.44 11.08 2413 662130 142850 45878669
Injection site induration 27.37 11.08 203 664340 7876 46013643
Hepatitis B virus test positive 27.21 11.08 23 664520 184 46021335
Product label confusion 27.20 11.08 29 664514 319 46021200
Coma scale abnormal 27.14 11.08 19 664524 4987 46016532
Therapeutic response unexpected 27.10 11.08 122 664421 15494 46006025
Gastric disorder 26.97 11.08 532 664011 26173 45995346
Haematotoxicity 26.87 11.08 180 664363 6753 46014766
Drug specific antibody 26.85 11.08 57 664486 1203 46020316
Abortion induced 26.84 11.08 67 664476 10193 46011326
Meningoencephalitis herpetic 26.81 11.08 52 664491 1026 46020493
Infective tenosynovitis 26.38 11.08 24 664519 214 46021305
Eye irritation 26.38 11.08 134 664409 16480 46005039
Lower respiratory tract infection viral 26.36 11.08 35 664508 493 46021026
Bicytopenia 26.36 11.08 67 664476 1597 46019922
Adactyly 26.35 11.08 12 664531 24 46021495
Erythema 26.35 11.08 1715 662828 141105 45880414
Coccidioidomycosis 26.25 11.08 46 664497 837 46020682
Tuberculous pleurisy 26.23 11.08 32 664511 412 46021107
Hyperventilation 26.19 11.08 25 664518 5622 46015897
Toe operation 26.17 11.08 37 664506 555 46020964
Sickle cell anaemia with crisis 26.16 11.08 12 664531 3980 46017539
Throat tightness 26.11 11.08 179 664364 20460 46001059
Hepatitis cholestatic 26.09 11.08 34 664509 6643 46014876
Laryngeal disorder 26.09 11.08 45 664498 808 46020711
Respiration abnormal 26.09 11.08 16 664527 4505 46017014
Poor venous access 26.04 11.08 205 664338 8103 46013416
Squamous cell carcinoma 26.04 11.08 196 664347 7640 46013879
Left ventricular dysfunction 26.03 11.08 68 664475 10187 46011332
Migraine 26.02 11.08 778 663765 69248 45952271
Injection site discolouration 25.95 11.08 178 664365 6732 46014787
Chondropathy 25.85 11.08 74 664469 1896 46019623
Dermatitis psoriasiform 25.77 11.08 68 664475 1659 46019860
Azotaemia 25.67 11.08 15 664528 4336 46017183
International normalised ratio abnormal 25.65 11.08 6 664537 3053 46018466
Lung transplant 25.63 11.08 5 664538 2887 46018632
Urine leukocyte esterase positive 25.62 11.08 3 664540 2532 46018987
Wheelchair user 25.54 11.08 119 664424 3889 46017630
Blood bicarbonate decreased 25.54 11.08 5 664538 2880 46018639
Rectal cancer 25.47 11.08 71 664472 1791 46019728
Dysphoria 25.44 11.08 17 664526 4572 46016947
Embolic stroke 25.35 11.08 10 664533 3629 46017890
Pulse absent 25.34 11.08 20 664523 4936 46016583
Cartilage atrophy 25.34 11.08 21 664522 163 46021356
Empyema 25.25 11.08 70 664473 1760 46019759
Growth failure 25.19 11.08 27 664516 299 46021220
Rhinitis allergic 25.17 11.08 37 664506 6871 46014648
Skin papilloma 25.17 11.08 122 664421 4054 46017465
Spinal pain 25.16 11.08 233 664310 9659 46011860
Coronary arterial stent insertion 25.14 11.08 5 664538 2848 46018671
Granuloma 25.12 11.08 114 664429 3684 46017835
Infected dermal cyst 25.10 11.08 32 664511 432 46021087
Disease susceptibility 25.08 11.08 22 664521 186 46021333
Ankle operation 24.84 11.08 54 664489 1159 46020360
Bunion operation 24.82 11.08 43 664500 775 46020744
Prescribed underdose 24.82 11.08 88 664455 11965 46009554
Dermatomyositis 24.69 11.08 74 664469 1947 46019572
Palmoplantar pustulosis 24.67 11.08 28 664515 332 46021187
Ganglioneuroma 24.67 11.08 19 664524 131 46021388
Bundle branch block left 24.58 11.08 33 664510 6366 46015153
Isosporiasis 24.53 11.08 13 664530 41 46021478
Ventricular arrhythmia 24.50 11.08 9 664534 3412 46018107
Maternal exposure during pregnancy 24.47 11.08 1201 663342 101348 45920171
Renal disorder 24.46 11.08 252 664291 26434 45995085
Alcohol use 24.41 11.08 3 664540 2439 46019080
Live birth 24.36 11.08 71 664472 10259 46011260
Product prescribing error 24.31 11.08 176 664367 19871 46001648
Varicella 24.28 11.08 66 664477 1640 46019879
Haemorrhagic stroke 24.26 11.08 26 664517 5540 46015979
Breast cancer metastatic 24.25 11.08 106 664437 13572 46007947
Therapy change 24.23 11.08 22 664521 5068 46016451
Asphyxia 24.21 11.08 24 664519 5302 46016217
Traumatic lung injury 24.14 11.08 59 664484 1371 46020148
Performance status decreased 24.07 11.08 8 664535 3229 46018290
Mean platelet volume decreased 23.97 11.08 62 664481 1494 46020025
Anaemia megaloblastic 23.93 11.08 27 664516 318 46021201
Walking aid user 23.92 11.08 133 664410 4667 46016852
Blood thyroid stimulating hormone increased 23.86 11.08 29 664514 5840 46015679
Obsessive-compulsive disorder 23.81 11.08 8 664535 3207 46018312
Drooling 23.74 11.08 8 664535 3201 46018318
Myocardial ischaemia 23.72 11.08 97 664446 12652 46008867
Synovial rupture 23.66 11.08 20 664523 160 46021359
Jaundice cholestatic 23.63 11.08 22 664521 5007 46016512
Ataxia 23.48 11.08 110 664433 13820 46007699
Rheumatoid factor 23.45 11.08 14 664529 59 46021460
Neck mass 23.41 11.08 101 664442 3192 46018327
Anaplastic large-cell lymphoma 23.39 11.08 17 664526 106 46021413
Diffuse large B-cell lymphoma stage III 23.31 11.08 12 664531 35 46021484
Exostosis 23.29 11.08 236 664307 10027 46011492
Ovarian cancer 23.27 11.08 151 664392 5604 46015915
Amylase increased 23.24 11.08 26 664517 5433 46016086
Nail disorder 23.21 11.08 192 664351 7704 46013815
Salivary gland cancer 23.16 11.08 18 664525 126 46021393
Chest X-ray abnormal 23.15 11.08 110 664433 3625 46017894
Systemic lupus erythematosus rash 23.12 11.08 54 664489 1218 46020301
Mood swings 23.10 11.08 136 664407 16116 46005403
Nodular melanoma 23.05 11.08 13 664530 48 46021471
Pulmonary nocardiosis 23.02 11.08 16 664527 92 46021427
Blood triglycerides increased 22.97 11.08 88 664455 11695 46009824
Peptic ulcer haemorrhage 22.95 11.08 47 664496 966 46020553
Engraftment syndrome 22.72 11.08 24 664519 261 46021258
Middle lobe syndrome 22.68 11.08 11 664532 27 46021492
Blood chloride decreased 22.66 11.08 26 664517 5371 46016148
Steroid dependence 22.62 11.08 16 664527 95 46021424
Mucormycosis 22.61 11.08 78 664465 2214 46019305
Back pain 22.54 11.08 2631 661912 207408 45814111
Urticarial vasculitis 22.52 11.08 30 664513 424 46021095
Clostridium difficile colitis 22.44 11.08 163 664380 18390 46003129
Catheterisation cardiac 22.42 11.08 15 664528 4032 46017487
Pelvic pain 22.39 11.08 87 664456 11515 46010004
Cystitis haemorrhagic 22.37 11.08 105 664438 3442 46018077
Hepatitis 22.37 11.08 609 663934 31606 45989913
Bone tuberculosis 22.36 11.08 20 664523 174 46021345
Restless legs syndrome 22.29 11.08 133 664410 15710 46005809
Anaphylactic shock 22.24 11.08 183 664360 20091 46001428
Immune thrombocytopenia 22.20 11.08 53 664490 8188 46013331
Biliary dyskinesia 22.17 11.08 6 664537 2767 46018752
Malignant melanoma in situ 22.15 11.08 41 664502 780 46020739
Feeling hot 22.10 11.08 393 664150 37535 45983984
Granulomatosis with polyangiitis 22.03 11.08 66 664477 1736 46019783
Tendon disorder 22.03 11.08 134 664409 4861 46016658
Tearfulness 22.02 11.08 16 664527 4119 46017400
Blood phosphorus decreased 22.02 11.08 14 664529 3866 46017653
Taste disorder 21.89 11.08 31 664512 5847 46015672
Myelitis transverse 21.83 11.08 47 664496 1002 46020517
Colitis microscopic 21.79 11.08 164 664379 6392 46015127
Intervertebral disc space narrowing 21.78 11.08 42 664501 825 46020694
Application site rash 21.78 11.08 5 664538 2577 46018942
Pruritus allergic 21.76 11.08 47 664496 1004 46020515
Blood albumin decreased 21.74 11.08 111 664432 13634 46007885
Red blood cell sedimentation rate 21.73 11.08 65 664478 1708 46019811
Anaemia macrocytic 21.73 11.08 85 664458 2568 46018951
Hair follicle tumour benign 21.71 11.08 27 664516 355 46021164
Cardiac murmur 21.70 11.08 86 664457 11318 46010201
Hallucinations, mixed 21.69 11.08 14 664529 3835 46017684
Borrelia infection 21.65 11.08 17 664526 121 46021398
Malnutrition 21.63 11.08 114 664429 13889 46007630
Haemolysis 21.55 11.08 33 664510 6026 46015493
Alcoholism 21.51 11.08 3 664540 2215 46019304
Device occlusion 21.51 11.08 32 664511 5913 46015606
Legionella infection 21.48 11.08 28 664515 387 46021132
Hyperlactacidaemia 21.47 11.08 3 664540 2212 46019307
Myocarditis 21.47 11.08 49 664494 7690 46013829
Bedridden 21.45 11.08 212 664331 8947 46012572
Therapeutic product effect delayed 21.42 11.08 68 664475 1847 46019672
Acquired claw toe 21.42 11.08 20 664523 185 46021334
JC virus infection 21.39 11.08 62 664481 1600 46019919
Therapeutic response shortened 21.38 11.08 137 664406 5062 46016457
Adjustment disorder with depressed mood 21.38 11.08 49 664494 1091 46020428
Decreased immune responsiveness 21.35 11.08 105 664438 3510 46018009
Diverticular perforation 21.30 11.08 99 664444 3232 46018287
Lymphadenopathy 21.29 11.08 626 663917 32862 45988657
Myelodysplastic syndrome 21.27 11.08 328 664215 15383 46006136
Mass excision 21.23 11.08 23 664520 258 46021261
Catheter site pain 21.23 11.08 14 664529 3792 46017727
Acute graft versus host disease in liver 21.22 11.08 35 664508 605 46020914
Overlap syndrome 21.22 11.08 34 664509 573 46020946
Hepatosplenomegaly 21.21 11.08 79 664464 2331 46019188
Pharyngeal ulceration 21.15 11.08 32 664511 512 46021007
Post-traumatic stress disorder 21.12 11.08 16 664527 4032 46017487
Thrombophlebitis superficial 21.11 11.08 24 664519 4979 46016540
Foot fracture 21.10 11.08 394 664149 19188 46002331
Immunodeficiency 21.08 11.08 282 664261 12824 46008695
Injection site hypersensitivity 21.07 11.08 58 664485 1452 46020067
Acute pulmonary oedema 21.06 11.08 51 664492 7840 46013679
Cervix carcinoma stage 0 21.01 11.08 25 664518 313 46021206
Hypermobility syndrome 21.01 11.08 36 664507 643 46020876
Apathy 21.00 11.08 45 664498 7223 46014296
Epstein-Barr virus test positive 20.98 11.08 33 664510 547 46020972
Infusion site haemorrhage 20.95 11.08 3 664540 2171 46019348
Cardiac failure acute 20.94 11.08 53 664490 8025 46013494
Vascular device infection 20.92 11.08 12 664531 3505 46018014
Malignant neoplasm of conjunctiva 20.92 11.08 11 664532 34 46021485
Blood lactic acid increased 20.91 11.08 30 664513 5627 46015892
Alanine aminotransferase increased 20.88 11.08 1037 663506 87414 45934105
Eosinophil count increased 20.86 11.08 51 664492 7815 46013704
Acute myeloid leukaemia 20.82 11.08 328 664215 15450 46006069
Hypovolaemic shock 20.66 11.08 26 664517 5157 46016362
Bursitis 20.62 11.08 397 664146 19445 46002074
Mesenteritis 20.61 11.08 17 664526 131 46021388
Rash macular 20.60 11.08 175 664368 19085 46002434
Fear-related avoidance of activities 20.58 11.08 15 664528 94 46021425
Cyst 20.57 11.08 263 664280 11837 46009682
Diffuse large B-cell lymphoma stage II 20.57 11.08 12 664531 48 46021471
Nausea 20.46 11.08 9164 655379 678290 45343229
Infiltration anaesthesia 20.41 11.08 17 664526 133 46021386
Tendon rupture 20.37 11.08 184 664359 7575 46013944
Prosthesis user 20.34 11.08 14 664529 79 46021440
Purpura 20.31 11.08 73 664470 9885 46011634
Oesophageal carcinoma 20.29 11.08 40 664503 799 46020720
Secondary immunodeficiency 20.28 11.08 44 664499 943 46020576
Maternal exposure before pregnancy 20.26 11.08 121 664422 4360 46017159
Glioma 20.25 11.08 23 664520 273 46021246
Malignant peritoneal neoplasm 20.25 11.08 36 664507 663 46020856
Abscess sweat gland 20.23 11.08 8 664535 9 46021510
Cytomegalovirus infection 20.23 11.08 367 664176 17777 46003742
Laryngitis fungal 20.21 11.08 17 664526 135 46021384
Cancer pain 20.16 11.08 5 664538 2445 46019074
Thirst 20.11 11.08 84 664459 10892 46010627
Alcohol interaction 20.10 11.08 5 664538 2440 46019079
Dermatitis acneiform 20.09 11.08 17 664526 4053 46017466
Erythema induratum 19.96 11.08 10 664533 27 46021492
Ocular sarcoidosis 19.96 11.08 10 664533 27 46021492
Subdural abscess 19.96 11.08 10 664533 27 46021492
Abdominal wall haematoma 19.94 11.08 8 664535 2873 46018646
Hypokinesia 19.92 11.08 88 664455 11234 46010285
Sinus node dysfunction 19.87 11.08 19 664524 4270 46017249
Erythrodermic psoriasis 19.85 11.08 41 664502 848 46020671
Catheter site infection 19.84 11.08 23 664520 4730 46016789
Plasmablastic lymphoma 19.84 11.08 21 664522 229 46021290
Galactorrhoea 19.82 11.08 15 664528 3782 46017737
Post procedural haemorrhage 19.81 11.08 48 664495 7378 46014141
Emotional disorder 19.79 11.08 99 664444 12225 46009294
Swollen joint count increased 19.74 11.08 77 664466 2323 46019196
Enterovirus test positive 19.73 11.08 16 664527 120 46021399
Major depression 19.68 11.08 41 664502 6649 46014870
Tongue neoplasm 19.63 11.08 11 664532 40 46021479
Arthritis viral 19.60 11.08 6 664537 0 46021519
Oropharyngeal discolouration 19.60 11.08 6 664537 0 46021519
Osteophyte fracture 19.60 11.08 6 664537 0 46021519
Electrocardiogram T wave inversion 19.52 11.08 13 664530 3503 46018016
Hypersomnia 19.48 11.08 134 664409 15305 46006214
Cardioactive drug level increased 19.47 11.08 3 664540 2056 46019463
Myelitis 19.47 11.08 48 664495 1122 46020397
Gastric cancer 19.43 11.08 88 664455 2841 46018678
Eczema herpeticum 19.43 11.08 14 664529 86 46021433
Human rhinovirus test positive 19.42 11.08 16 664527 123 46021396
Hypoventilation 19.29 11.08 18 664525 4092 46017427
Inadequate analgesia 19.28 11.08 8 664535 2816 46018703
Blood thyroid stimulating hormone decreased 19.28 11.08 17 664526 3972 46017547
Hypergammaglobulinaemia benign monoclonal 19.28 11.08 34 664509 622 46020897
Squamous cell carcinoma of the oral cavity 19.27 11.08 23 664520 289 46021230
Angina unstable 19.20 11.08 50 664493 7498 46014021
Anal abscess 19.17 11.08 101 664442 3471 46018048
Eye movement disorder 19.15 11.08 24 664519 4769 46016750
Discomfort 19.15 11.08 830 663713 45840 45975679
Knee deformity 19.11 11.08 38 664505 764 46020755
Logorrhoea 19.06 11.08 5 664538 2354 46019165
Chronic recurrent multifocal osteomyelitis 19.04 11.08 11 664532 43 46021476
Dermatitis contact 19.03 11.08 56 664487 8067 46013452
Thyroid cancer 19.02 11.08 107 664436 3771 46017748
Lip and/or oral cavity cancer 19.00 11.08 22 664521 267 46021252
Hyperthermia 18.95 11.08 55 664488 7959 46013560
Euglycaemic diabetic ketoacidosis 18.92 11.08 3 664540 2013 46019506
Cutaneous sarcoidosis 18.88 11.08 24 664519 323 46021196
Sensory disturbance 18.88 11.08 100 664443 12167 46009352
Lyme disease 18.78 11.08 75 664468 2288 46019231
Refusal of treatment by patient 18.77 11.08 30 664513 5385 46016134
Subdural haemorrhage 18.71 11.08 9 664534 2903 46018616
Blood pH decreased 18.67 11.08 7 664536 2620 46018899
Mycobacterium avium complex infection 18.66 11.08 81 664462 2567 46018952
Incoherent 18.66 11.08 22 664521 4490 46017029
Back injury 18.62 11.08 165 664378 6756 46014763
Decubitus ulcer 18.61 11.08 75 664468 9823 46011696
Cardiomyopathy 18.59 11.08 143 664400 15930 46005589
Accidental overdose 18.59 11.08 189 664354 19877 46001642
Lichen myxoedematosus 18.58 11.08 9 664534 22 46021497
Stress at work 18.57 11.08 43 664500 964 46020555
Q fever 18.55 11.08 12 664531 60 46021459
Accidental exposure to product 18.54 11.08 201 664342 20880 46000639
Squamous cell carcinoma of the cervix 18.52 11.08 22 664521 275 46021244
Feeling jittery 18.51 11.08 87 664456 10921 46010598
Listeriosis 18.44 11.08 47 664496 1122 46020397
Scleroderma renal crisis 18.44 11.08 21 664522 250 46021269
Catheter site discharge 18.36 11.08 3 664540 1969 46019550
Self-injurious ideation 18.34 11.08 5 664538 2295 46019224
Rheumatoid vasculitis 18.34 11.08 24 664519 333 46021186
Oropharyngeal cancer 18.33 11.08 10 664533 34 46021485
Nocturia 18.33 11.08 47 664496 7085 46014434
Varicella zoster pneumonia 18.31 11.08 9 664534 23 46021496
Gastritis 18.24 11.08 362 664181 34016 45987503
Cytomegalovirus chorioretinitis 18.24 11.08 55 664488 1452 46020067
Exercise tolerance decreased 18.20 11.08 23 664520 4554 46016965
Nephrolithiasis 18.15 11.08 607 663936 32444 45989075
Metatarsalgia 18.12 11.08 18 664525 181 46021338
Hepatic function abnormal 18.10 11.08 363 664180 34058 45987461
Labelled drug-drug interaction medication error 18.10 11.08 67 664476 8994 46012525
Eructation 18.04 11.08 49 664494 7246 46014273
Oesophagitis 17.96 11.08 117 664426 13534 46007985
Lacrimation increased 17.93 11.08 142 664401 15719 46005800
Social avoidant behaviour 17.90 11.08 9 664534 2830 46018689
Pharyngeal abscess 17.89 11.08 19 664524 208 46021311
Pleural fibrosis 17.86 11.08 99 664444 3470 46018049
Maculopathy 17.83 11.08 57 664486 1554 46019965
Extrasystoles 17.82 11.08 26 664517 4843 46016676
Malignant neoplasm of ampulla of Vater 17.79 11.08 9 664534 25 46021494
Haematochezia 17.79 11.08 402 664141 37091 45984428
Lung cancer metastatic 17.78 11.08 76 664467 2392 46019127
Blood sodium increased 17.77 11.08 7 664536 2542 46018977
Pyomyositis 17.72 11.08 24 664519 345 46021174
Chemotherapeutic drug level above therapeutic 17.71 11.08 10 664533 37 46021482
Tachyarrhythmia 17.68 11.08 24 664519 4608 46016911
Amenorrhoea 17.62 11.08 66 664477 8829 46012690
Abdominal pain upper 17.57 11.08 1805 662738 143500 45878019
Electrocardiogram ST segment elevation 17.56 11.08 16 664527 3679 46017840
Cryptococcosis 17.53 11.08 38 664505 814 46020705
Spinal disorder 17.49 11.08 183 664360 7841 46013678
Influenza 17.48 11.08 1487 663056 87783 45933736
Device leakage 17.42 11.08 31 664512 5334 46016185
Cervical dysplasia 17.36 11.08 86 664457 2883 46018636
Road traffic accident 17.36 11.08 235 664308 23456 45998063
Gestational trophoblastic tumour 17.33 11.08 10 664533 39 46021480
Guttate psoriasis 17.32 11.08 24 664519 353 46021166
Muscle haemorrhage 17.32 11.08 13 664530 3291 46018228
Ocular lymphoma 17.31 11.08 11 664532 53 46021466
Tonsil cancer 17.31 11.08 18 664525 192 46021327
Brachiocephalic artery stenosis 17.31 11.08 9 664534 27 46021492
Heart rate irregular 17.27 11.08 175 664368 18416 46003103
Mucosal disorder 17.25 11.08 63 664480 1841 46019678
Bursitis infective 17.22 11.08 46 664497 1131 46020388
Intervertebral disc protrusion 17.21 11.08 396 664147 20009 46001510
Eye pruritus 17.21 11.08 99 664444 11799 46009720
Urticaria 17.19 11.08 1444 663099 116448 45905071
Bipolar disorder 17.16 11.08 49 664494 7128 46014391
Skin burning sensation 17.11 11.08 86 664457 10606 46010913
Abdominal pain lower 17.04 11.08 206 664337 20975 46000544
Metastases to central nervous system 16.97 11.08 92 664451 11129 46010390
Rash erythematous 16.96 11.08 366 664177 33984 45987535
Stress 16.96 11.08 897 663646 50654 45970865
Injection site discomfort 16.89 11.08 97 664446 3445 46018074
Gastrointestinal inflammation 16.87 11.08 112 664431 4189 46017330
Personality disorder 16.84 11.08 12 664531 3121 46018398
Carbon dioxide decreased 16.83 11.08 3 664540 1848 46019671
Episcleritis 16.82 11.08 35 664508 728 46020791
Libido decreased 16.81 11.08 8 664535 2597 46018922
Laryngospasm 16.81 11.08 10 664533 2863 46018656
Premature rupture of membranes 16.80 11.08 23 664520 4400 46017119
Disseminated varicella zoster virus infection 16.79 11.08 34 664509 693 46020826
Exposure to toxic agent 16.79 11.08 4 664539 2010 46019509
Keratitis 16.77 11.08 75 664468 2408 46019111
Growth retardation 16.77 11.08 40 664503 915 46020604
Sleep disorder due to general medical condition, insomnia type 16.72 11.08 130 664413 5119 46016400
Exposure to communicable disease 16.70 11.08 28 664515 491 46021028
Bradyarrhythmia 16.69 11.08 4 664539 2002 46019517
Cholesteatoma 16.66 11.08 14 664529 111 46021408
Intervertebral discitis 16.63 11.08 76 664467 2463 46019056
Myeloid leukaemia 16.61 11.08 22 664521 309 46021210
Double stranded DNULL antibody positive 16.61 11.08 18 664525 202 46021317
Respiratory rate increased 16.61 11.08 95 664448 11338 46010181
Renal cancer 16.61 11.08 89 664454 3079 46018440
Retinitis 16.59 11.08 24 664519 368 46021151
Chronic villitis of unknown etiology 16.59 11.08 6 664537 4 46021515
Adverse event 16.59 11.08 619 663924 33565 45987954
Thrombosis in device 16.56 11.08 11 664532 2968 46018551
Metastatic bronchial carcinoma 16.56 11.08 14 664529 112 46021407
Inhibitory drug interaction 16.56 11.08 4 664539 1991 46019528
Cutaneous tuberculosis 16.55 11.08 15 664528 133 46021386
Infusion site extravasation 16.51 11.08 31 664512 5225 46016294
Weight decreased 16.48 11.08 2693 661850 208156 45813363
Hyperuricaemia 16.48 11.08 26 664517 4691 46016828
Psychiatric symptom 16.47 11.08 24 664519 4473 46017046
Catheter site haemorrhage 16.47 11.08 9 664534 2700 46018819
T-cell lymphoma 16.45 11.08 31 664512 598 46020921
Urine ketone body present 16.45 11.08 5 664538 2137 46019382
Incorrect dose administered 16.44 11.08 508 664035 45042 45976477
Cardiac pacemaker insertion 16.44 11.08 17 664526 3682 46017837
Application site irritation 16.43 11.08 3 664540 1816 46019703
Angle closure glaucoma 16.42 11.08 5 664538 2134 46019385
Wernicke's encephalopathy 16.41 11.08 9 664534 31 46021488
Lung squamous cell carcinoma stage I 16.41 11.08 7 664536 11 46021508
Bone density abnormal 16.41 11.08 87 664456 2997 46018522
Large granular lymphocytosis 16.41 11.08 16 664527 157 46021362
Torus fracture 16.40 11.08 13 664530 94 46021425
Leukodystrophy 16.39 11.08 8 664535 20 46021499
Extra dose administered 16.39 11.08 26 664517 4681 46016838
Ammonia increased 16.39 11.08 23 664520 4354 46017165
Exposed bone in jaw 16.33 11.08 13 664530 3195 46018324
Angioimmunoblastic T-cell lymphoma stage III 16.33 11.08 5 664538 0 46021519
Respiratory tract ulceration 16.33 11.08 5 664538 0 46021519
Pertussis 16.30 11.08 30 664513 568 46020951
Electrocardiogram ST segment depression 16.29 11.08 9 664534 2684 46018835
Pleuropericarditis 16.28 11.08 18 664525 207 46021312
Rales 16.26 11.08 76 664467 9555 46011964
Snoring 16.24 11.08 15 664528 3427 46018092
Thrombotic thrombocytopenic purpura 16.24 11.08 19 664524 3891 46017628
Quadriplegia 16.18 11.08 58 664485 1679 46019840
Product taste abnormal 16.17 11.08 4 664539 1959 46019560
Duodenal ulcer haemorrhage 16.16 11.08 7 664536 2401 46019118
Plasma cell myeloma recurrent 16.15 11.08 7 664536 2400 46019119
Drug-device interaction 16.13 11.08 11 664532 61 46021458
Coronary artery occlusion 16.12 11.08 60 664483 8042 46013477
Idiopathic pneumonia syndrome 16.08 11.08 23 664520 349 46021170
Portal tract inflammation 16.05 11.08 7 664536 12 46021507
Chronic graft versus host disease in liver 15.95 11.08 16 664527 163 46021356
Peripheral coldness 15.92 11.08 79 664464 9776 46011743
Insurance issue 15.91 11.08 3 664540 1775 46019744
Stoma site discharge 15.89 11.08 4 664539 1936 46019583
Nystagmus 15.88 11.08 36 664507 5663 46015856
Ecchymosis 15.84 11.08 87 664456 10489 46011030
Duodenal ulcer perforation 15.84 11.08 188 664355 8314 46013205
Cholestatic liver injury 15.83 11.08 5 664538 2085 46019434
Soft tissue disorder 15.82 11.08 108 664435 4078 46017441
Infection reactivation 15.78 11.08 35 664508 762 46020757
Rib fracture 15.77 11.08 183 664360 18771 46002748
Cardiovascular disorder 15.76 11.08 105 664438 12082 46009437
Meningitis tuberculous 15.73 11.08 29 664514 550 46020969
Perineal infection 15.72 11.08 14 664529 121 46021398
Endometrial adenocarcinoma 15.71 11.08 44 664499 1113 46020406
International normalised ratio decreased 15.71 11.08 25 664518 4495 46017024
Femoroacetabular impingement 15.70 11.08 7 664536 13 46021506
Cytomegalovirus enteritis 15.67 11.08 17 664526 191 46021328
Respiratory tract congestion 15.60 11.08 262 664281 12502 46009017
Fracture 15.59 11.08 325 664218 16146 46005373
Infusion site reaction 15.58 11.08 58 664485 1711 46019808
Metastasis 15.56 11.08 110 664433 4202 46017317
Herpes virus infection 15.55 11.08 119 664424 4663 46016856
Ocular toxicity 15.54 11.08 26 664517 455 46021064
Gallbladder necrosis 15.53 11.08 6 664537 6 46021513
Tendon graft 15.53 11.08 6 664537 6 46021513
Wound infection 15.48 11.08 220 664323 10139 46011380
Electrocardiogram T wave abnormal 15.46 11.08 7 664536 2339 46019180
Mononeuritis 15.43 11.08 9 664534 36 46021483
Hyperparathyroidism 15.42 11.08 8 664535 2471 46019048
Atelectasis 15.40 11.08 182 664361 18608 46002911
Pulmonary function test decreased 15.40 11.08 19 664524 3801 46017718
Ischaemic cardiomyopathy 15.39 11.08 9 664534 2601 46018918
Post procedural inflammation 15.38 11.08 8 664535 24 46021495
Lower respiratory tract inflammation 15.38 11.08 13 664530 104 46021415
Nasopharyngeal cancer 15.37 11.08 7 664536 14 46021505
Rotator cuff syndrome 15.37 11.08 241 664302 11342 46010177
Medication error 15.36 11.08 329 664214 30582 45990937
Ventricular hypertrophy 15.34 11.08 19 664524 3795 46017724
Respiratory rate decreased 15.34 11.08 13 664530 3097 46018422
Blood pressure diastolic decreased 15.34 11.08 286 664257 13925 46007594
Histiocytic sarcoma 15.34 11.08 11 664532 67 46021452
Herpes zoster oticus 15.33 11.08 18 664525 222 46021297
Pneumocystis jirovecii infection 15.33 11.08 46 664497 1211 46020308
Sinus arrest 15.32 11.08 3 664540 1728 46019791
Iris adhesions 15.30 11.08 21 664522 306 46021213
Protein total decreased 15.29 11.08 35 664508 5488 46016031
Premature separation of placenta 15.29 11.08 3 664540 1725 46019794
Eye infection toxoplasmal 15.26 11.08 20 664523 278 46021241
Tubular breast carcinoma 15.24 11.08 9 664534 37 46021482
Implant site pain 15.22 11.08 6 664537 2178 46019341
Arteriosclerosis coronary artery 15.21 11.08 62 664481 8094 46013425
Chorioretinopathy 15.19 11.08 33 664510 708 46020811
Fatigue 15.17 11.08 8160 656383 600537 45420982
Genital infection 15.16 11.08 10 664533 52 46021467
Diastolic dysfunction 15.09 11.08 33 664510 5259 46016260
Portal fibrosis 15.08 11.08 17 664526 200 46021319
Papulopustular rosacea 15.06 11.08 7 664536 15 46021504
Economic problem 15.01 11.08 5 664538 2015 46019504
Hypoglycaemic coma 15.01 11.08 9 664534 2565 46018954
Concomitant disease progression 14.97 11.08 6 664537 2156 46019363
Left ventricular hypertrophy 14.95 11.08 30 664513 4933 46016586
Quadrantanopia 14.93 11.08 8 664535 26 46021493
Communication disorder 14.91 11.08 8 664535 2425 46019094
Cytomegalovirus viraemia 14.87 11.08 112 664431 4366 46017153
Haemodynamic instability 14.86 11.08 58 664485 7667 46013852
Neck deformity 14.86 11.08 59 664484 1795 46019724
Folate deficiency 14.85 11.08 56 664487 1662 46019857
Throat cancer 14.84 11.08 25 664518 440 46021079
Blood pressure diastolic increased 14.84 11.08 140 664403 5834 46015685
Skin swelling 14.83 11.08 63 664480 1977 46019542
Gastrointestinal lymphoma 14.72 11.08 9 664534 40 46021479
Deafness neurosensory 14.70 11.08 112 664431 4382 46017137
Body height decreased 14.68 11.08 79 664464 9573 46011946
Chloroma 14.67 11.08 16 664527 181 46021338
Duodenal ulcer 14.66 11.08 53 664490 7165 46014354
Anxiety disorder 14.65 11.08 17 664526 3494 46018025
Follicle centre lymphoma, follicular grade I, II, III 14.61 11.08 11 664532 73 46021446
Gout 14.61 11.08 98 664445 11258 46010261
DNULL antibody positive 14.57 11.08 21 664522 321 46021198
Invasive ductal breast carcinoma 14.56 11.08 143 664400 6025 46015494
Respiratory tract haemorrhage 14.54 11.08 22 664521 352 46021167
Inflammatory pain 14.51 11.08 30 664513 621 46020898
Mean cell volume decreased 14.50 11.08 71 664472 2369 46019150
Immunisation reaction 14.48 11.08 7 664536 17 46021502
Herpes simplex 14.47 11.08 162 664381 7061 46014458
Acute interstitial pneumonitis 14.45 11.08 31 664512 659 46020860
Intestinal sepsis 14.45 11.08 18 664525 237 46021282
Central nervous system lesion 14.45 11.08 79 664464 9536 46011983
Hypertensive crisis 14.43 11.08 124 664419 13491 46008028
Tension 14.37 11.08 12 664531 2880 46018639
Pleural thickening 14.36 11.08 74 664469 2521 46018998
Lip oedema 14.35 11.08 16 664527 3348 46018171
Anal cancer 14.30 11.08 25 664518 454 46021065
Mucosal necrosis 14.29 11.08 8 664535 29 46021490
Root canal infection 14.28 11.08 13 664530 116 46021403
Osteochondrosis 14.28 11.08 38 664505 932 46020587
Second primary malignancy 14.27 11.08 150 664393 6434 46015085
Abscess limb 14.27 11.08 107 664436 4166 46017353
Corneal oedema 14.26 11.08 3 664540 1643 46019876
Skin mass 14.26 11.08 126 664417 5154 46016365
BK virus infection 14.23 11.08 79 664464 2770 46018749
Psoriasis area severity index increased 14.22 11.08 9 664534 43 46021476
Akinesia 14.21 11.08 4 664539 1797 46019722
Tibia fracture 14.20 11.08 111 664432 4378 46017141
Supraventricular extrasystoles 14.20 11.08 23 664520 4106 46017413
Fungal infection 14.19 11.08 534 664009 28986 45992533
Cystic fibrosis 14.19 11.08 19 664524 3669 46017850
Scarlet fever 14.15 11.08 11 664532 77 46021442
Oral disorder 14.15 11.08 172 664371 7650 46013869
Immune system disorder 14.11 11.08 175 664368 7820 46013699
Cerebral haematoma 14.11 11.08 16 664527 3323 46018196
Monoclonal gammopathy 14.10 11.08 29 664514 598 46020921
Septic arthritis staphylococcal 14.09 11.08 23 664520 394 46021125
Tongue oedema 14.07 11.08 22 664521 3984 46017535
Renal artery stenosis 14.05 11.08 4 664539 1784 46019735
Malabsorption 14.04 11.08 20 664523 3763 46017756
Skin tightness 14.04 11.08 21 664522 3872 46017647
Fontanelle bulging 14.02 11.08 5 664538 3 46021516
Food allergy 14.02 11.08 51 664492 6882 46014637
Extremity contracture 14.02 11.08 43 664500 1146 46020373
Medial tibial stress syndrome 14.00 11.08 12 664531 98 46021421
Stress cardiomyopathy 14.00 11.08 60 664483 7724 46013795
Crying 13.98 11.08 214 664329 20927 46000592
Waldenstrom's macroglobulinaemia 13.95 11.08 7 664536 19 46021500
Intervertebral disc compression 13.93 11.08 38 664505 946 46020573
Small intestinal haemorrhage 13.91 11.08 5 664538 1921 46019598
Uterine cancer 13.90 11.08 91 664452 3387 46018132
Bone cyst 13.89 11.08 62 664481 1989 46019530
Dyspepsia 13.87 11.08 815 663728 67657 45953862
Meningitis 13.87 11.08 141 664402 5995 46015524
Lung adenocarcinoma stage III 13.86 11.08 6 664537 10 46021509
Polymerase chain reaction 13.86 11.08 6 664537 10 46021509
Pasteurella infection 13.86 11.08 6 664537 10 46021509
Protein urine present 13.82 11.08 33 664510 5098 46016421
Electroencephalogram abnormal 13.78 11.08 20 664523 3734 46017785
Subcutaneous abscess 13.77 11.08 121 664422 4942 46016577
Congestive hepatopathy 13.77 11.08 9 664534 2449 46019070
Genital cyst 13.76 11.08 9 664534 46 46021473
Nephrogenic anaemia 13.76 11.08 5 664538 1908 46019611
Peripheral T-cell lymphoma unspecified 13.75 11.08 17 664526 222 46021297
Eye infection 13.74 11.08 194 664349 8929 46012590
Blood lactate dehydrogenase increased 13.73 11.08 207 664336 20293 46001226
Oesophageal squamous cell carcinoma 13.72 11.08 12 664531 101 46021418
Bone disorder 13.71 11.08 378 664165 19655 46001864
West Nile viral infection 13.64 11.08 22 664521 373 46021146
Bronchiolitis obliterans syndrome 13.62 11.08 11 664532 82 46021437
Micturition urgency 13.61 11.08 61 664482 7756 46013763
Euphoric mood 13.59 11.08 25 664518 4247 46017272
Multiple-drug resistance 13.56 11.08 10 664533 2555 46018964
Bursitis infective staphylococcal 13.53 11.08 8 664535 33 46021486
Anaplastic thyroid cancer 13.53 11.08 8 664535 33 46021486
Urine abnormality 13.52 11.08 38 664505 5556 46015963
Hip surgery 13.51 11.08 70 664473 2390 46019129
Diabetic retinopathy 13.49 11.08 8 664535 2294 46019225
Cervix carcinoma 13.48 11.08 75 664468 2632 46018887
Subclavian artery occlusion 13.46 11.08 7 664536 21 46021498
Combined immunodeficiency 13.45 11.08 12 664531 104 46021415
Cytomegalovirus gastrointestinal ulcer 13.45 11.08 5 664538 4 46021515
Lymphoplasmacytoid lymphoma/immunocytoma 13.45 11.08 5 664538 4 46021515
Impetigo 13.45 11.08 37 664506 926 46020593
Vaginal cancer 13.42 11.08 17 664526 228 46021291
Blood urine present 13.41 11.08 111 664432 12171 46009348
Ovarian epithelial cancer 13.40 11.08 20 664523 316 46021203
Morphoea 13.39 11.08 19 664524 286 46021233
Ocular vasculitis 13.35 11.08 8 664535 34 46021485
Foreign body sensation in eyes 13.33 11.08 5 664538 1871 46019648
Prosthesis implantation 13.32 11.08 10 664533 66 46021453
T-cell type acute leukaemia 13.32 11.08 10 664533 66 46021453
Vasculitic rash 13.29 11.08 45 664498 1265 46020254
Dyspnoea at rest 13.29 11.08 19 664524 3569 46017950
Appendicitis 13.28 11.08 145 664398 6281 46015238
Bursa disorder 13.28 11.08 12 664531 106 46021413
Bowen's disease 13.25 11.08 17 664526 231 46021288
Papilloma viral infection 13.25 11.08 46 664497 1310 46020209
Erythema migrans 13.23 11.08 7 664536 22 46021497
Effusion 13.22 11.08 49 664494 1442 46020077
Loose body in joint 13.22 11.08 39 664504 1017 46020502
Iridocyclitis 13.20 11.08 60 664483 1940 46019579
Intramedullary rod insertion 13.20 11.08 7 664536 2136 46019383
Perineal necrosis 13.19 11.08 12 664531 107 46021412
Joint tuberculosis 13.19 11.08 12 664531 107 46021412
Rash morbilliform 13.18 11.08 14 664529 2995 46018524
Metastases to reproductive organ 13.18 11.08 6 664537 12 46021507
DNULL antibody 13.18 11.08 8 664535 35 46021484
Joint surgery 13.17 11.08 20 664523 321 46021198
Pulmonary granuloma 13.17 11.08 45 664498 1271 46020248
Blood parathyroid hormone increased 13.17 11.08 14 664529 2994 46018525
N-terminal prohormone brain natriuretic peptide increased 13.13 11.08 4 664539 1707 46019812
Musculoskeletal chest pain 13.12 11.08 180 664363 17926 46003593
Clear cell renal cell carcinoma 13.10 11.08 38 664505 981 46020538
Muscle injury 13.08 11.08 116 664427 4750 46016769
Cutaneous T-cell lymphoma recurrent 13.07 11.08 4 664539 0 46021519
Bladder papilloma 13.07 11.08 4 664539 0 46021519
Ectrodactyly 13.07 11.08 4 664539 0 46021519
Bursa injury 13.07 11.08 4 664539 0 46021519
CSF myelin basic protein increased 13.07 11.08 4 664539 0 46021519
Leptotrichia infection 13.07 11.08 4 664539 0 46021519
Thrombotic microangiopathy 13.06 11.08 178 664365 8128 46013391
Breast mass 13.06 11.08 141 664402 6090 46015429
Pneumonia adenoviral 13.01 11.08 7 664536 23 46021496
Petit mal epilepsy 13.00 11.08 16 664527 3204 46018315
Expired product administered 12.99 11.08 39 664504 5583 46015936
Anovulatory cycle 12.99 11.08 13 664530 132 46021387
Furuncle 12.98 11.08 119 664424 4919 46016600
Injection related reaction 12.90 11.08 25 664518 493 46021026
Tumour marker increased 12.87 11.08 19 664524 3522 46017997
Tender joint count increased 12.87 11.08 6 664537 13 46021506
Cutaneous lymphoma 12.86 11.08 14 664529 158 46021361
Blood chloride increased 12.85 11.08 11 664532 2608 46018911
Chromosomal deletion 12.84 11.08 8 664535 37 46021482
Abscess bacterial 12.84 11.08 15 664528 184 46021335
Pseudomonas test positive 12.83 11.08 31 664512 715 46020804
Arthritis enteropathic 12.83 11.08 16 664527 211 46021308
Allergy to vaccine 12.79 11.08 14 664529 159 46021360
Bloody discharge 12.79 11.08 37 664506 954 46020565
Serum ferritin decreased 12.78 11.08 52 664491 1600 46019919
Pemphigoid 12.78 11.08 40 664503 5651 46015868
Breast pain 12.78 11.08 60 664483 7534 46013985
Cytomegalovirus infection reactivation 12.74 11.08 48 664495 1424 46020095
Bone marrow disorder 12.70 11.08 55 664488 1741 46019778
Transplant dysfunction 12.70 11.08 30 664513 4652 46016867
Pyoderma gangrenosum 12.69 11.08 74 664469 2643 46018876
Right ventricular dysfunction 12.69 11.08 3 664540 1515 46020004
Diffuse alveolar damage 12.69 11.08 32 664511 759 46020760
Infected seroma 12.65 11.08 9 664534 54 46021465
Brain oedema 12.63 11.08 115 664428 12363 46009156
Skin bacterial infection 12.62 11.08 17 664526 243 46021276
Craniosynostosis 12.62 11.08 13 664530 137 46021382
Skin neoplasm excision 12.62 11.08 27 664516 573 46020946
Device failure 12.61 11.08 43 664500 5916 46015603
Nodal osteoarthritis 12.61 11.08 32 664511 762 46020757
Larynx irritation 12.60 11.08 12 664531 114 46021405
Seasonal allergy 12.60 11.08 125 664418 13209 46008310
Pterygium 12.60 11.08 14 664529 162 46021357
Enzyme level increased 12.59 11.08 15 664528 188 46021331
Pneumonia influenzal 12.57 11.08 3 664540 1506 46020013
Granulomatous lymphadenitis 12.55 11.08 13 664530 138 46021381
Hiatus hernia 12.54 11.08 184 664359 18118 46003401
Dysphonia 12.54 11.08 434 664109 37980 45983539
Ocular hyperaemia 12.53 11.08 201 664342 19509 46002010
Stenosis 12.53 11.08 33 664510 804 46020715
Adenocarcinoma of the cervix 12.53 11.08 14 664529 163 46021356
Generalised anxiety disorder 12.53 11.08 4 664539 1656 46019863
Lipodystrophy acquired 12.53 11.08 3 664540 1502 46020017
Brain death 12.51 11.08 13 664530 2810 46018709
Homicidal ideation 12.48 11.08 5 664538 1797 46019722
Myxoid liposarcoma 12.48 11.08 5 664538 6 46021513
Genital herpes 12.46 11.08 50 664493 1529 46019990
Chronic cutaneous lupus erythematosus 12.45 11.08 11 664532 94 46021425
Product container issue 12.44 11.08 5 664538 1794 46019725
Maternal exposure timing unspecified 12.43 11.08 3 664540 1494 46020025
Breath sounds abnormal 12.42 11.08 63 664480 7752 46013767
Blood pressure increased 12.40 11.08 1596 662947 125070 45896449
Vitreous floaters 12.39 11.08 34 664509 5011 46016508
Decreased interest 12.37 11.08 16 664527 3136 46018383
Hypoacusis 12.30 11.08 217 664326 20752 46000767
Aortic arteriosclerosis 12.30 11.08 41 664502 5680 46015839
CSF cell count increased 12.30 11.08 6 664537 15 46021504
Middle insomnia 12.29 11.08 82 664461 9433 46012086
Ischaemia 12.28 11.08 28 664515 4396 46017123
Tuberculosis gastrointestinal 12.28 11.08 20 664523 342 46021177
Herpes zoster meningitis 12.28 11.08 9 664534 57 46021462
Panic reaction 12.27 11.08 21 664522 3668 46017851
Blood glucose abnormal 12.26 11.08 51 664492 6621 46014898
Cellulitis 12.26 11.08 1161 663382 69127 45952392
Ileal perforation 12.24 11.08 20 664523 343 46021176
Lymphangitis 12.24 11.08 34 664509 856 46020663
Vulval cancer 12.22 11.08 29 664514 661 46020858
Swollen joint count 12.22 11.08 17 664526 251 46021268
Creatinine urine abnormal 12.19 11.08 7 664536 27 46021492
Molluscum contagiosum 12.19 11.08 15 664528 195 46021324
Drug ineffective for unapproved indication 12.18 11.08 313 664230 16100 46005419
Anal incontinence 12.16 11.08 108 664435 11670 46009849
Medulloblastoma recurrent 12.13 11.08 10 664533 77 46021442
Onychomadesis 12.12 11.08 76 664467 2787 46018732
Non-cardiac chest pain 12.10 11.08 45 664498 6033 46015486
Poor quality product administered 12.09 11.08 15 664528 2994 46018525
Feeling cold 12.08 11.08 191 664352 18580 46002939
Graft versus host disease in lung 12.08 11.08 19 664524 315 46021204
Injection site vesicles 12.07 11.08 72 664471 2593 46018926
Solar urticaria 12.07 11.08 8 664535 42 46021477
Complicated appendicitis 12.05 11.08 5 664538 7 46021512
Laryngitis 12.04 11.08 193 664350 9123 46012396
Laryngitis viral 12.03 11.08 6 664537 16 46021503
Application site vesicles 12.03 11.08 3 664540 1461 46020058
Bronchopleural fistula 12.02 11.08 16 664527 226 46021293
Abscess rupture 12.02 11.08 15 664528 198 46021321
Parapsoriasis 12.01 11.08 11 664532 99 46021420
Photopsia 12.01 11.08 24 664519 3952 46017567
Eczema 12.01 11.08 211 664332 20189 46001330
Diffuse axonal injury 12.00 11.08 7 664536 28 46021491
Sluggishness 11.99 11.08 31 664512 4660 46016859
Blood creatine increased 11.99 11.08 30 664513 4560 46016959
Generalised oedema 11.98 11.08 139 664404 14260 46007259
Candida test positive 11.97 11.08 35 664508 908 46020611
Infusion site infection 11.96 11.08 3 664540 1456 46020063
Peritonitis 11.95 11.08 215 664328 20499 46001020
Infected bite 11.95 11.08 44 664499 1291 46020228
Brain injury 11.94 11.08 46 664497 6104 46015415
Bronchioloalveolar carcinoma 11.93 11.08 10 664533 79 46021440
Therapeutic response delayed 11.89 11.08 25 664518 524 46020995
Retroperitoneal haematoma 11.88 11.08 12 664531 2628 46018891
Device physical property issue 11.84 11.08 3 664540 1446 46020073
Polymyositis 11.84 11.08 50 664493 1565 46019954
Kidney infection 11.83 11.08 318 664225 16471 46005048
Large intestine anastomosis 11.81 11.08 7 664536 29 46021490
Cardiac failure chronic 11.77 11.08 20 664523 3504 46018015
Human herpesvirus 6 infection 11.77 11.08 67 664476 2372 46019147
Toxic leukoencephalopathy 11.76 11.08 25 664518 528 46020991
Breast cancer in situ 11.75 11.08 47 664496 1435 46020084
Initial insomnia 11.70 11.08 29 664514 4423 46017096
Staphylococcal sepsis 11.68 11.08 161 664382 7371 46014148
Tubal rupture 11.67 11.08 5 664538 8 46021511
Cryptococcus test positive 11.67 11.08 5 664538 8 46021511
Torulopsis infection 11.67 11.08 5 664538 8 46021511
Conjunctival deposit 11.67 11.08 5 664538 8 46021511
Intestinal adenocarcinoma 11.66 11.08 13 664530 151 46021368
Subarachnoid haemorrhage 11.63 11.08 102 664441 11051 46010468
Human bocavirus infection 11.62 11.08 19 664524 326 46021193
C-reactive protein 11.62 11.08 19 664524 326 46021193
Retinal injury 11.58 11.08 15 664528 206 46021313
Genital tract inflammation 11.54 11.08 6 664537 18 46021501
Bone sarcoma 11.54 11.08 6 664537 18 46021501
Diabetic eye disease 11.53 11.08 13 664530 153 46021366
Polydipsia 11.52 11.08 18 664525 3261 46018258
Eye pain 11.50 11.08 306 664237 27634 45993885
Haemoperitoneum 11.50 11.08 11 664532 2471 46019048
Streptococcal infection 11.47 11.08 113 664430 4765 46016754
Affect lability 11.46 11.08 67 664476 7953 46013566
Cushingoid 11.43 11.08 138 664405 6128 46015391
Gastric neoplasm 11.42 11.08 17 664526 268 46021251
Orthopnoea 11.41 11.08 44 664499 5836 46015683
Mouth swelling 11.37 11.08 22 664521 3667 46017852
Pancreatolithiasis 11.37 11.08 16 664527 239 46021280
Hydronephrosis 11.36 11.08 73 664470 8472 46013047
Type I hypersensitivity 11.34 11.08 10 664533 2336 46019183
Thromboangiitis obliterans 11.31 11.08 5 664538 9 46021510
Local reaction 11.31 11.08 22 664521 435 46021084
Herpes simplex meningoencephalitis 11.30 11.08 7 664536 32 46021487
Gallbladder disorder 11.28 11.08 178 664365 17320 46004199
Retinal deposits 11.25 11.08 9 664534 66 46021453
Urine analysis abnormal 11.25 11.08 27 664516 4163 46017356
Conduction disorder 11.22 11.08 3 664540 1395 46020124
Felty's syndrome 11.20 11.08 11 664532 109 46021410
Medical device pain 11.19 11.08 4 664539 1542 46019977
Infective exacerbation of bronchiectasis 11.19 11.08 20 664523 370 46021149
Ventricular hypokinesia 11.17 11.08 26 664517 4052 46017467
Device alarm issue 11.13 11.08 3 664540 1387 46020132
Localised oedema 11.13 11.08 36 664507 5033 46016486
Rectal cancer metastatic 11.13 11.08 16 664527 244 46021275
Flank pain 11.12 11.08 112 664431 11801 46009718
Psoas abscess 11.11 11.08 20 664523 372 46021147
Parkinson's disease 11.11 11.08 4 664539 1535 46019984
Contusion 11.09 11.08 1083 663460 86404 45935115
Drug level increased 11.09 11.08 190 664353 18251 46003268

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 4436.93 11.18 9140 241832 331247 29370259
Rheumatoid arthritis 2999.13 11.18 2597 248375 38600 29662906
Drug intolerance 1384.03 11.18 1799 249173 43492 29658014
Death 1294.36 11.18 695 250277 356588 29344918
Joint swelling 1281.70 11.18 1765 249207 45181 29656325
Synovitis 997.57 11.18 752 250220 9031 29692475
Arthralgia 894.03 11.18 2832 248140 132959 29568547
Treatment failure 858.90 11.18 1245 249727 33434 29668072
Therapeutic product effect incomplete 799.33 11.18 1188 249784 32646 29668860
Psoriatic arthropathy 756.05 11.18 790 250182 14971 29686535
Psoriasis 755.44 11.18 1311 249661 41195 29660311
Completed suicide 685.79 11.18 36 250936 99456 29602050
Drug abuse 649.50 11.18 7 250965 82065 29619441
Therapeutic product effect decreased 637.17 11.18 986 249986 28090 29673416
Musculoskeletal stiffness 627.46 11.18 1099 249873 34782 29666724
Mucosal inflammation 604.78 11.18 988 249984 29506 29672000
Acute graft versus host disease 558.71 11.18 433 250539 5431 29696075
Contraindicated product administered 553.21 11.18 702 250270 16529 29684977
Drug hypersensitivity 489.68 11.18 1472 249500 67047 29634459
Arthropathy 466.82 11.18 712 250260 20015 29681491
Hypotension 416.19 11.18 649 250323 199916 29501590
Chronic graft versus host disease 396.43 11.18 306 250666 3813 29697693
Stomatitis 372.91 11.18 907 250065 36372 29665134
Arthritis 371.40 11.18 704 250268 23697 29677809
Lymphoproliferative disorder 356.90 11.18 230 250742 2100 29699406
Bone erosion 343.00 11.18 223 250749 2070 29699436
Dyspnoea 337.40 11.18 1543 249429 331752 29369754
Rhabdomyolysis 327.26 11.18 67 250905 63513 29637993
Hyperkalaemia 322.76 11.18 78 250894 65932 29635574
Posterior reversible encephalopathy syndrome 321.92 11.18 381 250591 8326 29693180
Fall 319.04 11.18 653 250319 181219 29520287
Constipation 318.77 11.18 286 250686 112620 29588886
Dehydration 318.68 11.18 339 250633 123200 29578306
Febrile neutropenia 317.53 11.18 1745 249227 104948 29596558
Leukoencephalopathy 316.45 11.18 265 250707 3737 29697769
Plasma cell myeloma 295.32 11.18 47 250925 53415 29648091
Product use in unapproved indication 293.74 11.18 1310 249662 72383 29629123
C-reactive protein abnormal 287.37 11.18 291 250681 5302 29696204
Drug clearance decreased 282.83 11.18 160 250812 1123 29700383
Graft versus host disease 281.59 11.18 385 250587 9765 29691741
Cardiac failure congestive 277.40 11.18 183 250789 84224 29617282
Apparent death 272.77 11.18 231 250741 3311 29698195
Dizziness 268.66 11.18 793 250179 194116 29507390
Confusional state 267.39 11.18 449 250523 134385 29567121
Acute graft versus host disease in skin 259.96 11.18 250 250722 4266 29697240
Acute kidney injury 255.05 11.18 1305 249667 272537 29428969
Pain 249.84 11.18 2373 248599 170268 29531238
Cardiac arrest 248.16 11.18 247 250725 92603 29608903
Venoocclusive liver disease 240.55 11.18 287 250685 6326 29695180
Liver function test increased 232.56 11.18 371 250601 10845 29690661
International normalised ratio increased 230.24 11.18 58 250914 47681 29653825
Pain in extremity 224.59 11.18 1637 249335 108584 29592922
Febrile bone marrow aplasia 224.41 11.18 307 250665 7790 29693716
Pancytopenia 224.01 11.18 1347 249625 83705 29617801
Intentional overdose 221.28 11.18 40 250932 41441 29660065
Pneumocystis jirovecii pneumonia 220.83 11.18 461 250511 16659 29684847
Anaemia 218.82 11.18 948 250024 207044 29494462
Bradycardia 218.06 11.18 140 250832 65386 29636120
Overdose 217.82 11.18 231 250741 84106 29617400
Syncope 212.15 11.18 239 250733 84664 29616842
Epstein-Barr virus infection 210.10 11.18 270 250702 6436 29695070
Hypofibrinogenaemia 210.04 11.18 145 250827 1500 29700006
Hallucination 208.70 11.18 75 250897 48984 29652522
Red blood cell sedimentation rate increased 207.34 11.18 280 250692 7015 29694491
Diarrhoea 206.52 11.18 1800 249172 332303 29369203
Decreased appetite 205.60 11.18 611 250361 149299 29552207
Asthenia 200.48 11.18 1064 249908 220226 29481280
Basal cell carcinoma 198.35 11.18 425 250547 15643 29685863
Mobility decreased 197.31 11.18 571 250401 25428 29676078
Pulmonary fibrosis 196.97 11.18 421 250551 15469 29686037
Atrial fibrillation 192.90 11.18 384 250588 107740 29593766
Electrocardiogram QT prolonged 192.34 11.18 34 250938 35801 29665705
Hypoglycaemia 191.09 11.18 94 250878 50887 29650619
Red blood cell sedimentation rate abnormal 191.05 11.18 141 250831 1634 29699872
Myelopathy 190.32 11.18 146 250826 1801 29699705
Bone marrow failure 185.90 11.18 611 250361 29174 29672332
Loss of personal independence in daily activities 183.15 11.18 493 250479 21042 29680464
Somnolence 182.81 11.18 332 250640 96431 29605075
Fatigue 182.32 11.18 1764 249208 318909 29382597
Haemoglobin decreased 180.62 11.18 433 250539 113665 29587841
Diverticulitis 179.23 11.18 429 250543 17016 29684490
Hand deformity 177.73 11.18 138 250834 1735 29699771
Epstein-Barr virus associated lymphoproliferative disorder 176.46 11.18 133 250839 1595 29699911
Tuberculosis 175.52 11.18 273 250699 7804 29693702
Agitation 173.87 11.18 120 250852 53953 29647553
Cardio-respiratory arrest 172.84 11.18 136 250836 57170 29644336
Blood glucose increased 172.14 11.18 157 250815 61373 29640133
Hospitalisation 168.71 11.18 80 250892 44239 29657267
Joint stiffness 167.73 11.18 290 250682 9071 29692435
Osteoarthritis 166.15 11.18 430 250542 17919 29683587
Aggression 164.67 11.18 52 250920 36855 29664651
Ankylosing spondylitis 160.36 11.18 194 250778 4340 29697166
Acute lymphocytic leukaemia recurrent 159.88 11.18 151 250821 2516 29698990
Knee arthroplasty 159.86 11.18 216 250756 5414 29696092
Gastrointestinal haemorrhage 159.67 11.18 284 250688 83162 29618344
Diffuse large B-cell lymphoma 153.89 11.18 253 250719 7588 29693918
Suicide attempt 152.87 11.18 58 250914 36639 29664867
Malignant neoplasm progression 149.42 11.18 234 250738 72053 29629453
Hyponatraemia 149.19 11.18 207 250765 66995 29634511
Off label use 147.70 11.18 2918 248054 246372 29455134
Infection 146.69 11.18 1138 249834 76936 29624570
Rheumatoid nodule 146.37 11.18 118 250854 1572 29699934
Loss of consciousness 144.89 11.18 278 250694 79097 29622409
Nodule 144.10 11.18 189 250783 4599 29696907
Neurotoxicity 142.83 11.18 331 250641 12851 29688655
Blood creatine phosphokinase increased 142.71 11.18 96 250876 43752 29657754
Angiocentric lymphoma 142.12 11.18 64 250908 254 29701252
Injection site pain 140.95 11.18 565 250407 29745 29671761
Foot deformity 139.79 11.18 158 250814 3279 29698227
Haemophagocytic lymphohistiocytosis 137.33 11.18 273 250699 9518 29691988
Disability 137.02 11.18 177 250795 4241 29697265
Anxiety 136.74 11.18 348 250624 89523 29611983
Graft versus host disease in gastrointestinal tract 135.02 11.18 147 250825 2922 29698584
Lymphoma 133.39 11.18 275 250697 9846 29691660
Suicidal ideation 131.71 11.18 69 250903 36045 29665461
Blood creatinine increased 131.30 11.18 364 250608 91011 29610495
Inflammation 129.59 11.18 443 250529 21583 29679923
C-reactive protein increased 124.36 11.18 704 250268 42769 29658737
Drug interaction 123.40 11.18 1074 249898 198494 29503012
Cystitis haemorrhagic 122.95 11.18 175 250797 4612 29696894
Pulmonary tuberculosis 122.46 11.18 176 250796 4681 29696825
Neuroleptic malignant syndrome 122.12 11.18 3 250969 16292 29685214
Arthritis bacterial 121.81 11.18 168 250804 4296 29697210
Sarcoidosis 120.55 11.18 131 250841 2598 29698908
Gastrointestinal disorder 117.12 11.18 507 250465 27630 29673876
Cerebrovascular accident 116.63 11.18 337 250635 83140 29618366
Graft versus host disease in skin 116.14 11.18 141 250831 3166 29698340
Haematotoxicity 115.62 11.18 195 250777 5975 29695531
Sedation 112.45 11.18 6 250966 16367 29685139
Mouth ulceration 112.32 11.18 264 250708 10345 29691161
Lactic acidosis 110.37 11.18 62 250910 31151 29670355
Pneumonia aspiration 109.74 11.18 93 250879 37687 29663819
Myocardial infarction 109.11 11.18 612 250360 125013 29576493
Herpes zoster 108.56 11.18 518 250454 29425 29672081
Therapeutic response decreased 108.52 11.18 448 250524 23901 29677605
Chondropathy 107.59 11.18 75 250897 789 29700717
Nasopharyngitis 106.75 11.18 851 250121 57998 29643508
Metabolic acidosis 106.64 11.18 94 250878 37367 29664139
Drug withdrawal syndrome 105.84 11.18 19 250953 19790 29681716
Acute graft versus host disease in intestine 105.46 11.18 115 250857 2290 29699216
Visceral leishmaniasis 104.35 11.18 60 250912 436 29701070
Juvenile idiopathic arthritis 103.68 11.18 79 250893 964 29700542
Respiratory arrest 103.62 11.18 58 250914 29200 29672306
Drug reaction with eosinophilia and systemic symptoms 103.04 11.18 55 250917 28433 29673073
Product use issue 102.62 11.18 699 250273 45317 29656189
Rheumatoid factor positive 101.82 11.18 60 250912 459 29701047
Acute myocardial infarction 99.58 11.18 182 250790 52757 29648749
Product dose omission issue 99.57 11.18 412 250560 91219 29610287
Prostate cancer 99.18 11.18 431 250541 23526 29677980
Sleep disorder due to general medical condition, insomnia type 97.71 11.18 81 250891 1125 29700381
Grip strength decreased 97.40 11.18 105 250867 2063 29699443
Cardiac failure 96.39 11.18 366 250606 83052 29618454
Cutaneous leishmaniasis 96.14 11.18 38 250934 99 29701407
Histoplasmosis disseminated 95.79 11.18 73 250899 891 29700615
Skin plaque 95.71 11.18 135 250837 3527 29697979
Delirium 95.41 11.18 120 250852 40511 29660995
Intentional product misuse 95.10 11.18 90 250882 34577 29666929
Coma 93.39 11.18 121 250851 40328 29661178
Abnormal behaviour 93.36 11.18 49 250923 25574 29675932
Foetal exposure during pregnancy 92.89 11.18 103 250869 36768 29664738
Synovial cyst 91.85 11.18 92 250880 1653 29699853
Sacroiliitis 91.85 11.18 68 250904 792 29700714
Oxidative stress 91.18 11.18 27 250945 14 29701492
Immunosuppression 90.98 11.18 159 250813 5016 29696490
Toxicity to various agents 89.93 11.18 1000 249972 176183 29525323
Impaired work ability 89.78 11.18 166 250806 5477 29696029
Tuberculin test positive 89.68 11.18 71 250901 920 29700586
Dactylitis 88.93 11.18 53 250919 415 29701091
Musculoskeletal pain 88.44 11.18 501 250471 30439 29671067
Chest pain 88.10 11.18 600 250372 117027 29584479
Joint range of motion decreased 88.09 11.18 168 250804 5677 29695829
Anti-cyclic citrullinated peptide antibody positive 87.11 11.18 62 250910 676 29700830
Drug specific antibody present 86.50 11.18 96 250876 1951 29699555
Orthostatic hypotension 85.69 11.18 47 250925 23932 29677574
Squamous cell carcinoma 84.47 11.18 232 250740 10018 29691488
Cytomegalovirus infection 83.97 11.18 407 250565 23267 29678239
Delusion 83.58 11.18 4 250968 11985 29689521
Polyarthritis 83.21 11.18 119 250853 3150 29698356
Hypokalaemia 82.92 11.18 186 250786 50006 29651500
Disseminated tuberculosis 82.72 11.18 95 250877 2007 29699499
Hepatic enzyme increased 82.70 11.18 522 250450 32972 29668534
Tenosynovitis 82.29 11.18 123 250849 3392 29698114
Intentional self-injury 81.60 11.18 9 250963 13523 29687983
Peripheral swelling 80.93 11.18 825 250147 60249 29641257
Swelling 80.51 11.18 547 250425 35428 29666078
Spermatozoa abnormal 80.19 11.18 27 250945 35 29701471
Joint effusion 79.85 11.18 124 250848 3539 29697967
Tremor 79.30 11.18 343 250629 75020 29626486
Disease progression 78.97 11.18 372 250600 79502 29622004
Epidermal necrosis 78.18 11.18 48 250924 399 29701107
Pulmonary toxicity 77.13 11.18 137 250835 4379 29697127
Acute lymphocytic leukaemia 76.98 11.18 111 250861 2961 29698545
Platelet count decreased 76.68 11.18 547 250425 105582 29595924
Demyelination 76.65 11.18 102 250870 2518 29698988
Bone cyst 76.64 11.18 51 250921 494 29701012
Unevaluable event 76.60 11.18 92 250880 31693 29669813
Blood urea increased 76.51 11.18 90 250882 31291 29670215
Psychotic disorder 75.68 11.18 43 250929 21472 29680034
Chemotherapeutic drug level increased 74.72 11.18 37 250935 190 29701316
Mycobacterium tuberculosis complex test positive 74.66 11.18 63 250909 898 29700608
Vein rupture 74.53 11.18 53 250919 577 29700929
Restlessness 74.16 11.18 49 250923 22550 29678956
Hypocalcaemia 73.38 11.18 44 250928 21332 29680174
Serotonin syndrome 73.30 11.18 29 250943 17862 29683644
Depressed level of consciousness 73.13 11.18 130 250842 38092 29663414
Dislocation of vertebra 73.05 11.18 44 250928 352 29701154
Hyperglycaemia 71.69 11.18 115 250857 35085 29666421
Sensitivity to weather change 71.69 11.18 74 250898 1380 29700126
Bladder transitional cell carcinoma 70.99 11.18 95 250877 2358 29699148
Leukaemia recurrent 70.82 11.18 76 250896 1485 29700021
Pulmonary mass 70.60 11.18 226 250746 10636 29690870
Malignant melanoma 70.52 11.18 177 250795 7234 29694272
Cytogenetic abnormality 69.95 11.18 56 250916 738 29700768
Hepatotoxicity 69.49 11.18 319 250653 17826 29683680
Urinary retention 69.47 11.18 105 250867 32812 29668694
Atlantoaxial instability 69.42 11.18 40 250932 292 29701214
Cardiac disorder 69.07 11.18 144 250828 39749 29661757
Insomnia 68.92 11.18 478 250494 92858 29608648
Enthesopathy 68.47 11.18 102 250870 2804 29698702
Product quality issue 68.25 11.18 36 250936 18738 29682768
Spinal instability 67.88 11.18 40 250932 306 29701200
Injection site swelling 67.71 11.18 194 250778 8586 29692920
Angioedema 67.55 11.18 115 250857 34269 29667237
Injury 67.50 11.18 50 250922 21681 29679825
Mineral metabolism disorder 67.45 11.18 40 250932 310 29701196
Oedema peripheral 67.30 11.18 565 250407 105267 29596239
Venoocclusive disease 66.98 11.18 95 250877 2495 29699011
Central nervous system lymphoma 66.95 11.18 57 250915 823 29700683
Chronic kidney disease 66.85 11.18 135 250837 37703 29663803
X-ray abnormal 66.70 11.18 46 250926 475 29701031
Fear of injection 66.37 11.18 50 250922 599 29700907
Complications of bone marrow transplant 66.37 11.18 34 250938 190 29701316
Dyskinesia 65.57 11.18 52 250920 21782 29679724
Blood potassium increased 65.25 11.18 27 250945 16186 29685320
Hip arthroplasty 64.57 11.18 114 250858 3626 29697880
Rheumatoid factor negative 64.22 11.18 46 250926 507 29700999
Joint ankylosis 63.71 11.18 38 250934 298 29701208
Intervertebral disc space narrowing 63.70 11.18 49 250923 607 29700899
Onychoclasis 63.65 11.18 74 250898 1585 29699921
Uveitis 63.18 11.18 141 250831 5336 29696170
Wrist deformity 63.09 11.18 38 250934 304 29701202
Vomiting 63.02 11.18 1383 249589 218435 29483071
Finger deformity 63.00 11.18 58 250914 934 29700572
Coronary artery disease 62.80 11.18 210 250762 49502 29652004
Dysgeusia 62.77 11.18 69 250903 24732 29676774
Mucocutaneous ulceration 61.98 11.18 26 250946 83 29701423
Haemorrhage 61.45 11.18 190 250782 45889 29655617
Renal impairment 61.22 11.18 433 250539 83751 29617755
Multiple sclerosis relapse 61.20 11.18 9 250963 10853 29690653
Condition aggravated 61.19 11.18 1550 249422 136316 29565190
Pleurisy 60.68 11.18 126 250846 4534 29696972
Lymphadenopathy 60.23 11.18 380 250592 23996 29677510
Haematocrit decreased 60.01 11.18 103 250869 30596 29670910
Blood pressure fluctuation 59.98 11.18 298 250674 17205 29684301
Hallucination, visual 59.91 11.18 30 250942 16083 29685423
Melaena 59.67 11.18 113 250859 32324 29669182
Nightmare 59.51 11.18 14 250958 12062 29689444
Post transplant lymphoproliferative disorder 59.42 11.18 135 250837 5171 29696335
Respiratory depression 59.40 11.18 12 250960 11491 29690015
Stevens-Johnson syndrome 59.06 11.18 37 250935 17519 29683987
Oedema 58.96 11.18 175 250797 42818 29658688
Hypersensitivity 58.36 11.18 701 250271 53327 29648179
Depression 58.30 11.18 481 250491 89956 29611550
Haematemesis 57.82 11.18 81 250891 26122 29675384
Abscess 57.78 11.18 201 250771 9877 29691629
White blood cell count increased 57.71 11.18 157 250815 39516 29661990
Myalgia 57.39 11.18 391 250581 76276 29625230
Blood pressure decreased 57.34 11.18 202 250770 46873 29654633
Joint destruction 57.30 11.18 31 250941 197 29701309
Injection site haemorrhage 57.16 11.18 170 250802 7685 29693821
Acute graft versus host disease in liver 56.80 11.18 61 250911 1193 29700313
Pneumonia legionella 56.62 11.18 68 250904 1509 29699997
Balance disorder 56.46 11.18 140 250832 36353 29665153
Diabetic ketoacidosis 56.15 11.18 32 250940 15954 29685552
Hepatic steatosis 55.86 11.18 259 250713 14534 29686972
Extrapyramidal disorder 55.54 11.18 11 250961 10682 29690824
Acne cystic 55.24 11.18 40 250932 449 29701057
Skin lesion 55.18 11.18 303 250669 18191 29683315
Clinodactyly 55.04 11.18 26 250946 118 29701388
Skin ulcer 55.03 11.18 307 250665 18542 29682964
Blood potassium decreased 54.84 11.18 36 250936 16626 29684880
Schizophrenia 54.60 11.18 6 250966 9042 29692464
Histoplasmosis 54.58 11.18 60 250912 1206 29700300
Injection site bruising 54.53 11.18 160 250812 7178 29694328
Hypertriglyceridaemia 54.01 11.18 170 250802 7928 29693578
Chronic graft versus host disease in skin 53.48 11.18 46 250926 674 29700832
Mycobacterial infection 53.44 11.18 69 250903 1652 29699854
Inappropriate schedule of product administration 53.24 11.18 538 250434 39190 29662316
Limb discomfort 53.20 11.18 182 250790 8868 29692638
Rheumatoid lung 53.15 11.18 34 250938 306 29701200
Atrial flutter 52.48 11.18 27 250945 14254 29687252
Ventricular tachycardia 52.42 11.18 74 250898 23788 29677718
Drug eruption 52.20 11.18 287 250685 17239 29684267
Disease recurrence 52.05 11.18 246 250726 13915 29687591
Hypomagnesaemia 51.79 11.18 38 250934 16560 29684946
Engraftment syndrome 51.54 11.18 48 250924 785 29700721
Disorientation 51.42 11.18 117 250855 31301 29670205
Thrombotic microangiopathy 51.35 11.18 174 250798 8436 29693070
Sinus bradycardia 51.23 11.18 17 250955 11678 29689828
Pulmonary oedema 50.72 11.18 193 250779 43782 29657724
Fluid retention 50.59 11.18 82 250890 24916 29676590
Adenovirus infection 50.50 11.18 111 250861 4157 29697349
Full blood count decreased 50.33 11.18 35 250937 15682 29685824
Cardiogenic shock 49.58 11.18 41 250931 16820 29684686
Anhedonia 49.38 11.18 6 250966 8363 29693143
Mental status changes 49.36 11.18 153 250819 36926 29664580
Photosensitivity reaction 49.35 11.18 186 250786 9508 29691998
General physical health deterioration 49.07 11.18 568 250404 99376 29602130
Abdominal distension 48.69 11.18 207 250765 45502 29656004
Superior sagittal sinus thrombosis 48.28 11.18 31 250941 281 29701225
Irritability 48.17 11.18 74 250898 22976 29678530
Squamous cell carcinoma of lung 48.04 11.18 66 250906 1681 29699825
Kidney transplant rejection 47.90 11.18 4 250968 7505 29694001
Aplasia 47.77 11.18 105 250867 3932 29697574
Myoclonus 47.69 11.18 26 250946 13286 29688220
Miosis 47.33 11.18 5 250967 7771 29693735
Bursitis 47.33 11.18 113 250859 4473 29697033
Blood sodium decreased 47.31 11.18 38 250934 15818 29685688
Lung neoplasm malignant 47.23 11.18 251 250721 14881 29686625
Cutaneous T-cell lymphoma 47.01 11.18 57 250915 1278 29700228
Latent tuberculosis 46.85 11.18 48 250924 887 29700619
Colitis ulcerative 46.83 11.18 242 250730 14192 29687314
Skin cancer 46.71 11.18 160 250812 7801 29693705
Epstein Barr virus positive mucocutaneous ulcer 46.59 11.18 28 250944 223 29701283
Dystonia 46.52 11.18 12 250960 9715 29691791
Hypovolaemia 46.52 11.18 8 250964 8597 29692909
Joint arthroplasty 46.45 11.18 40 250932 587 29700919
Lupus-like syndrome 46.31 11.18 72 250900 2057 29699449
Pulmonary hypertension 45.96 11.18 55 250917 18981 29682525
Seizure 45.91 11.18 566 250406 97909 29603597
Mass 45.90 11.18 148 250824 6992 29694514
Cognitive disorder 45.83 11.18 80 250892 23610 29677896
Angioimmunoblastic T-cell lymphoma 45.80 11.18 32 250940 338 29701168
Flushing 44.95 11.18 114 250858 29378 29672128
Osteonecrosis of jaw 44.73 11.18 54 250918 18564 29682942
Intestinal polyp 44.68 11.18 46 250926 855 29700651
Blood glucose decreased 44.61 11.18 27 250945 13026 29688480
Cytomegalovirus chorioretinitis 44.48 11.18 90 250882 3178 29698328
Tachycardia 44.47 11.18 399 250573 73340 29628166
B-cell lymphoma 44.27 11.18 109 250863 4401 29697105
Urinary tract infection 44.24 11.18 399 250573 73260 29628246
Swollen tongue 44.10 11.18 28 250944 13164 29688342
Arthritis infective 43.63 11.18 80 250892 2622 29698884
Lung disorder 43.54 11.18 429 250543 31040 29670466
Muscle rigidity 43.08 11.18 16 250956 10245 29691261
Seronegative arthritis 43.04 11.18 43 250929 770 29700736
Vision blurred 42.94 11.18 192 250780 41624 29659882
Transient ischaemic attack 42.75 11.18 92 250880 25108 29676398
Abscess limb 42.39 11.18 86 250886 3043 29698463
Haemoptysis 42.25 11.18 127 250845 30951 29670555
Rash maculo-papular 42.12 11.18 94 250878 25324 29676182
Upper gastrointestinal haemorrhage 42.06 11.18 75 250897 21953 29679553
Fear 42.01 11.18 19 250953 10806 29690700
Dysphagia 42.00 11.18 290 250682 56408 29645098
Unresponsive to stimuli 41.93 11.18 100 250872 26319 29675187
Foetal methotrexate syndrome 41.70 11.18 11 250961 0 29701506
Subdural haematoma 41.51 11.18 59 250913 18913 29682593
Immunodeficiency 41.32 11.18 103 250869 4191 29697315
Arrhythmia 41.28 11.18 141 250831 33028 29668478
Inflammatory marker increased 41.27 11.18 86 250886 3102 29698404
Pulmonary thrombosis 41.24 11.18 132 250840 6211 29695295
Tooth fracture 41.07 11.18 87 250885 3175 29698331
Paranoia 40.94 11.18 17 250955 10171 29691335
Palpitations 40.92 11.18 144 250828 33429 29668077
Arachnoiditis 40.91 11.18 29 250943 314 29701192
Erectile dysfunction 40.90 11.18 55 250917 18047 29683459
Anal fistula 40.90 11.18 98 250874 3888 29697618
Haematuria 40.73 11.18 215 250757 44619 29656887
Epstein-Barr viraemia 40.51 11.18 44 250928 872 29700634
Acute myeloid leukaemia 40.40 11.18 274 250698 17732 29683774
Alanine aminotransferase abnormal 40.36 11.18 76 250896 2543 29698963
Hepatic encephalopathy 39.91 11.18 36 250936 14156 29687350
Craniosynostosis 39.83 11.18 25 250947 217 29701289
Poisoning 39.67 11.18 23 250949 11359 29690147
Wheezing 39.54 11.18 130 250842 30808 29670698
Decreased immune responsiveness 39.31 11.18 51 250921 1227 29700279
Viral haemorrhagic cystitis 39.20 11.18 42 250930 819 29700687
Cytology abnormal 39.11 11.18 30 250942 370 29701136
Renal injury 39.07 11.18 25 250947 11704 29689802
Treatment noncompliance 38.97 11.18 97 250875 25156 29676350
Peritoneal tuberculosis 38.84 11.18 30 250942 374 29701132
Rash 38.75 11.18 1269 249703 190620 29510886
Lymph node tuberculosis 38.51 11.18 32 250940 446 29701060
Musculoskeletal discomfort 38.18 11.18 128 250844 6172 29695334
Joint lock 38.02 11.18 46 250926 1029 29700477
Pustular psoriasis 37.97 11.18 57 250915 1578 29699928
Central nervous system leukaemia 37.84 11.18 25 250947 239 29701267
Jaundice 37.83 11.18 142 250830 32344 29669162
Non-Hodgkin's lymphoma 37.78 11.18 59 250913 1692 29699814
Angina pectoris 37.75 11.18 124 250848 29394 29672112
Arthrodesis 37.62 11.18 30 250942 393 29701113
Injection site erythema 37.55 11.18 221 250751 13613 29687893
Graft versus host disease in liver 37.28 11.18 44 250928 958 29700548
Acute promyelocytic leukaemia 37.21 11.18 34 250938 542 29700964
Head injury 37.17 11.18 53 250919 16967 29684539
Therapy non-responder 37.15 11.18 394 250578 29059 29672447
Cytomegalovirus viraemia 37.05 11.18 119 250853 5610 29695896
Fungal infection 36.75 11.18 217 250755 13383 29688123
Fibromyalgia 36.71 11.18 73 250899 2545 29698961
Eosinophilia 36.68 11.18 82 250890 22078 29679428
Clear cell renal cell carcinoma 36.51 11.18 42 250930 889 29700617
Molluscum contagiosum 36.50 11.18 25 250947 255 29701251
Amnesia 36.31 11.18 95 250877 24226 29677280
Depressed mood 36.23 11.18 54 250918 16975 29684531
Cerebral haemorrhage 36.22 11.18 147 250825 32740 29668766
Red blood cell count decreased 36.18 11.18 107 250865 26214 29675292
Erythrodermic psoriasis 36.17 11.18 38 250934 724 29700782
Therapy partial responder 36.01 11.18 89 250883 3602 29697904
Oral herpes 35.88 11.18 100 250872 4355 29697151
Glioma 35.82 11.18 26 250946 293 29701213
Human herpesvirus 8 infection 35.67 11.18 36 250936 653 29700853
Fluid overload 35.56 11.18 66 250906 19026 29682480
Oral disorder 35.54 11.18 94 250878 3968 29697538
Mucormycosis 35.51 11.18 111 250861 5157 29696349
Akathisia 35.41 11.18 4 250968 5900 29695606
Blood stem cell transplant failure 35.38 11.18 29 250943 396 29701110
Lymphocyte count decreased 35.38 11.18 66 250906 18989 29682517
Neutropenia 34.92 11.18 1362 249610 127178 29574328
Progressive multifocal leukoencephalopathy 34.91 11.18 159 250813 8854 29692652
Colitis 34.64 11.18 403 250569 30417 29671089
Chronic obstructive pulmonary disease 34.62 11.18 235 250737 45891 29655615
Hiccups 34.42 11.18 18 250954 9416 29692090
Neuropathy peripheral 34.39 11.18 401 250571 70074 29631432
Epstein-Barr virus infection reactivation 34.21 11.18 23 250949 227 29701279
Neutrophil count increased 34.17 11.18 47 250925 15276 29686230
Infusion related reaction 34.11 11.18 503 250469 40061 29661445
Pneumonia cryptococcal 34.09 11.18 36 250936 690 29700816
Obliterative bronchiolitis 34.07 11.18 46 250926 1152 29700354
Contraindication to medical treatment 34.04 11.18 30 250942 455 29701051
Facial paralysis 34.02 11.18 168 250804 9675 29691831
Haematoma 33.93 11.18 96 250876 23857 29677649
Heart rate increased 33.90 11.18 188 250784 38533 29662973
Hypoxia 33.86 11.18 248 250724 47606 29653900
Hepatic fibrosis 33.54 11.18 85 250887 3495 29698011
Ill-defined disorder 33.47 11.18 175 250797 10309 29691197
Hepatitis C 33.13 11.18 37 250935 13168 29688338
Failure to thrive 33.08 11.18 13 250959 8041 29693465
Gingivitis ulcerative 33.08 11.18 14 250958 46 29701460
Right ventricular failure 32.96 11.18 13 250959 8023 29693483
Staphylococcal sepsis 32.81 11.18 162 250810 9329 29692177
Palmar-plantar erythrodysaesthesia syndrome 32.77 11.18 46 250926 14824 29686682
Hepatic cirrhosis 32.69 11.18 238 250734 15761 29685745
Chromaturia 32.48 11.18 41 250931 13824 29687682
Myelitis transverse 32.48 11.18 41 250931 959 29700547
Device occlusion 32.41 11.18 6 250966 6114 29695392
Venous injury 32.37 11.18 23 250949 250 29701256
End stage renal disease 32.23 11.18 11 250961 7424 29694082
Varicella zoster virus infection 32.04 11.18 46 250926 1222 29700284
Cerebral venous sinus thrombosis 32.03 11.18 24 250948 285 29701221
Cutaneous lymphoma 31.94 11.18 15 250957 67 29701439
Faeces discoloured 31.89 11.18 42 250930 13904 29687602
Scleroderma 31.87 11.18 47 250925 1280 29700226
Cytomegalovirus infection reactivation 31.86 11.18 54 250918 1661 29699845
Disturbance in attention 31.85 11.18 88 250884 22041 29679465
Hepatitis cholestatic 31.85 11.18 13 250959 7859 29693647
Faecal calprotectin increased 31.78 11.18 44 250928 1129 29700377
Engraft failure 31.75 11.18 28 250944 425 29701081
Intervertebral discitis 31.54 11.18 54 250918 1675 29699831
Tardive dyskinesia 31.43 11.18 3 250969 5054 29696452
Osteosclerosis 31.35 11.18 44 250928 1144 29700362
Bursitis infective 31.20 11.18 29 250943 473 29701033
Memory impairment 31.19 11.18 183 250789 36991 29664515
Mucosal toxicity 31.08 11.18 20 250952 182 29701324
Lung adenocarcinoma 31.05 11.18 90 250882 4009 29697497
Herpes simplex oesophagitis 30.95 11.18 18 250954 134 29701372
Frequent bowel movements 30.88 11.18 146 250826 8259 29693247
Oropharyngeal pain 30.87 11.18 370 250602 28126 29673380
Troponin increased 30.72 11.18 18 250954 8839 29692667
Hyperhidrosis 30.35 11.18 388 250584 66702 29634804
Hyperbilirubinaemia 30.14 11.18 244 250728 16698 29684808
Medial tibial stress syndrome 30.12 11.18 10 250962 12 29701494
Speech disorder 29.96 11.18 105 250867 24407 29677099
Withdrawal syndrome 29.93 11.18 30 250942 11220 29690286
Drug tolerance decreased 29.87 11.18 42 250930 1094 29700412
Salivary hypersecretion 29.80 11.18 13 250959 7553 29693953
Myelosuppression 29.74 11.18 131 250841 7191 29694315
Blood calcium decreased 29.69 11.18 22 250950 9540 29691966
Spondyloarthropathy 29.62 11.18 27 250945 429 29701077
Sinusitis 29.42 11.18 417 250555 32928 29668578
Aspiration 29.39 11.18 27 250945 10524 29690982
Cytotoxic oedema 29.34 11.18 19 250953 175 29701331
Mucocutaneous leishmaniasis 29.18 11.18 13 250959 50 29701456
Tropical infectious disease 29.15 11.18 12 250960 36 29701470
Pseudostroke 29.15 11.18 12 250960 36 29701470
Pericarditis 29.11 11.18 146 250826 8460 29693046
Gastric disorder 28.98 11.18 169 250803 10374 29691132
Ileal stenosis 28.97 11.18 42 250930 1126 29700380
Tubulointerstitial nephritis 28.97 11.18 67 250905 17824 29683682
Myelitis 28.92 11.18 32 250940 648 29700858
Toxic leukoencephalopathy 28.88 11.18 20 250952 208 29701298
Abnormal dreams 28.85 11.18 16 250956 8099 29693407
Poisoning deliberate 28.79 11.18 7 250965 5897 29695609
Poor venous access 28.78 11.18 64 250908 2416 29699090
Cytomegalovirus test positive 28.55 11.18 81 250891 3564 29697942
Hallucination, auditory 28.53 11.18 24 250948 9765 29691741
Mania 28.50 11.18 21 250951 9133 29692373
Myelodysplastic syndrome 28.46 11.18 261 250711 18517 29682989
Gliosis 28.42 11.18 18 250954 159 29701347
Drug ineffective for unapproved indication 28.37 11.18 172 250800 10708 29690798
Oesophageal stenosis 28.30 11.18 49 250923 1534 29699972
Therapeutic response shortened 28.20 11.18 80 250892 3520 29697986
Emotional distress 28.05 11.18 56 250916 15709 29685797
Skin mass 27.88 11.18 78 250894 3404 29698102
Tricuspid valve incompetence 27.88 11.18 19 250953 8604 29692902
Exposure during pregnancy 27.87 11.18 22 250950 9239 29692267
Presyncope 27.75 11.18 58 250914 15998 29685508
Infectious pleural effusion 27.74 11.18 56 250916 1974 29699532
Iron deficiency anaemia 27.72 11.18 21 250951 9003 29692503
Septic arthritis staphylococcal 27.63 11.18 26 250946 431 29701075
Product substitution issue 27.57 11.18 26 250946 10009 29691497
Tenderness 27.31 11.18 108 250864 5647 29695859
Sweat gland tumour 27.18 11.18 25 250947 402 29701104
Epstein-Barr virus associated lymphoma 27.13 11.18 28 250944 522 29700984
Tooth loss 27.09 11.18 84 250888 3885 29697621
T-cell type acute leukaemia 26.99 11.18 18 250954 175 29701331
Bicytopenia 26.99 11.18 51 250921 1711 29699795
Gastrointestinal toxicity 26.97 11.18 55 250917 1953 29699553
Prothrombin time prolonged 26.88 11.18 23 250949 9280 29692226
Wrong technique in product usage process 26.87 11.18 152 250820 31003 29670503
Osteosarcoma 26.74 11.18 18 250954 178 29701328
Lipoma 26.64 11.18 46 250926 1437 29700069
Premature baby 26.63 11.18 63 250909 16628 29684878
Intestinal sepsis 26.59 11.18 25 250947 414 29701092
Angioimmunoblastic T-cell lymphoma stage III 26.53 11.18 7 250965 0 29701506
Serum procollagen type III N-terminal propeptide increased 26.53 11.18 13 250959 65 29701441
Mycobacterium marinum infection 26.52 11.18 20 250952 240 29701266
Symptom recurrence 26.48 11.18 17 250955 154 29701352
Meningitis haemophilus 26.48 11.18 8 250964 5 29701501
Bladder cancer 26.40 11.18 148 250824 8954 29692552
T-cell lymphoma 26.38 11.18 36 250936 911 29700595
Impaired healing 26.31 11.18 208 250764 14132 29687374
Meningitis listeria 26.25 11.18 23 250949 346 29701160
Second primary malignancy 26.03 11.18 114 250858 6242 29695264
Spondylitis 25.94 11.18 39 250933 1081 29700425
Acute myelomonocytic leukaemia 25.86 11.18 16 250956 135 29701371
Asthma 25.82 11.18 187 250785 35987 29665519
Chemotherapeutic drug level above therapeutic 25.79 11.18 9 250963 14 29701492
Oral mucosa erosion 25.72 11.18 33 250939 785 29700721
Aspergillus infection 25.70 11.18 160 250812 10054 29691452
Acidosis 25.69 11.18 29 250943 10272 29691234
Vertigo 25.67 11.18 100 250872 22535 29678971
Atrial septal defect 25.64 11.18 12 250960 6689 29694817
Leukopenia 25.63 11.18 634 250338 55525 29645981
Glycosylated haemoglobin increased 25.60 11.18 25 250947 9466 29692040
Lethargy 25.53 11.18 210 250762 39309 29662197
Shock haemorrhagic 25.46 11.18 27 250945 9838 29691668
Diffuse large B-cell lymphoma recurrent 25.42 11.18 55 250917 2037 29699469
Dysuria 25.30 11.18 100 250872 22441 29679065
Dry mouth 25.25 11.18 102 250870 22748 29678758
Prescribed underdose 25.21 11.18 17 250955 7742 29693764
Pyopneumothorax 25.14 11.18 12 250960 56 29701450
Aspiration bone marrow abnormal 24.89 11.18 14 250958 97 29701409
Bundle branch block right 24.87 11.18 14 250958 7028 29694478
Incorrect disposal of product 24.86 11.18 19 250953 233 29701273
Alcohol abuse 24.85 11.18 7 250965 5346 29696160
Cerebral venous thrombosis 24.85 11.18 28 250944 579 29700927
Therapeutic product effect delayed 24.81 11.18 38 250934 1071 29700435
Ankle deformity 24.72 11.18 18 250954 204 29701302
Lung cancer metastatic 24.71 11.18 61 250911 2467 29699039
Pruritus 24.70 11.18 778 250194 117426 29584080
Thinking abnormal 24.56 11.18 7 250965 5304 29696202
Encephalitis 24.53 11.18 113 250859 6323 29695183
Supraventricular tachycardia 24.46 11.18 30 250942 10242 29691264
Priapism 24.38 11.18 5 250967 4738 29696768
Axial spondyloarthritis 24.30 11.18 16 250956 152 29701354
Squamous cell carcinoma of the tongue 24.30 11.18 17 250955 180 29701326
Rheumatoid factor increased 24.23 11.18 25 250947 466 29701040
Acute lymphocytic leukaemia refractory 24.21 11.18 14 250958 103 29701403
Acute monocytic leukaemia 24.16 11.18 22 250950 349 29701157
Subdural hygroma 24.12 11.18 21 250951 313 29701193
Escherichia sepsis 24.07 11.18 81 250891 3913 29697593
Complications of transplanted kidney 24.05 11.18 3 250969 4098 29697408
Hepatic function abnormal 24.00 11.18 489 250483 41456 29660050
Hypoxic-ischaemic encephalopathy 23.97 11.18 5 250967 4682 29696824
Nephrolithiasis 23.82 11.18 315 250657 24495 29677011
Human rhinovirus test positive 23.79 11.18 16 250956 158 29701348
Osteosarcoma recurrent 23.75 11.18 9 250963 20 29701486
Pneumonia cytomegaloviral 23.75 11.18 64 250908 2732 29698774
Tongue disorder 23.74 11.18 85 250887 4237 29697269
Blood fibrinogen decreased 23.71 11.18 35 250937 954 29700552
Atrioventricular block first degree 23.66 11.18 9 250963 5679 29695827
Disseminated aspergillosis 23.60 11.18 13 250959 86 29701420
Bone sarcoma 23.60 11.18 13 250959 86 29701420
Urticaria 23.60 11.18 612 250360 53994 29647512
Pleuropericarditis 23.54 11.18 17 250955 190 29701316
Skin erosion 23.53 11.18 48 250924 1705 29699801
Sudden death 23.52 11.18 60 250912 15432 29686074
Fine motor skill dysfunction 23.51 11.18 38 250934 1123 29700383
Osteopenia 23.51 11.18 89 250883 4559 29696947
Actinomycotic pulmonary infection 23.50 11.18 8 250964 11 29701495
Macule 23.45 11.18 33 250939 860 29700646
Shock 23.43 11.18 105 250867 22754 29678752
Ventricular hypertrophy 23.43 11.18 6 250966 4881 29696625
Angina unstable 23.42 11.18 42 250930 12268 29689238
Low density lipoprotein increased 23.40 11.18 3 250969 4013 29697493
Extradural abscess 23.36 11.18 28 250944 620 29700886
Joint warmth 23.27 11.18 18 250954 225 29701281
Pneumocystis jirovecii infection 23.22 11.18 41 250931 1304 29700202
Injection site papule 23.20 11.18 20 250952 294 29701212
Neck pain 23.15 11.18 273 250699 20671 29680835
Blood loss anaemia 23.10 11.18 18 250954 7609 29693897
Hypophosphataemia 23.08 11.18 21 250951 8224 29693282
Neutropenic colitis 23.07 11.18 55 250917 2175 29699331
Pyoderma gangrenosum 23.04 11.18 36 250936 1033 29700473
Hepatic enzyme abnormal 23.00 11.18 55 250917 2179 29699327
Anger 22.95 11.18 36 250936 11084 29690422
Empyema 22.89 11.18 64 250908 2792 29698714
Iritis 22.88 11.18 40 250932 1262 29700244
Blood count abnormal 22.85 11.18 39 250933 11613 29689893
Bronchospasm 22.76 11.18 32 250940 10306 29691200
Paraplegia 22.69 11.18 61 250911 2600 29698906
Cerebral thrombosis 22.66 11.18 32 250940 837 29700669
Cheilitis 22.65 11.18 55 250917 2201 29699305
Bronchial carcinoma 22.64 11.18 33 250939 889 29700617
Granulomatous pneumonitis 22.62 11.18 9 250963 24 29701482
Limb deformity 22.61 11.18 24 250948 463 29701043
Ageusia 22.55 11.18 25 250947 8928 29692578
Granulocytopenia 22.54 11.18 12 250960 6214 29695292
Refractoriness to platelet transfusion 22.54 11.18 10 250962 38 29701468
Chest discomfort 22.48 11.18 258 250714 45222 29656284
Stenotrophomonas infection 22.43 11.18 45 250927 1579 29699927
Hodgkin's disease 22.37 11.18 33 250939 899 29700607
Joint tuberculosis 22.34 11.18 10 250962 39 29701467
Bone marrow transplant rejection 22.29 11.18 16 250956 177 29701329
Hyperthyroidism 22.23 11.18 21 250951 8077 29693429
Transaminases increased 22.18 11.18 297 250675 23160 29678346
Hypogammaglobulinaemia 22.12 11.18 95 250877 5157 29696349
Dyspnoea exertional 22.10 11.18 190 250782 35240 29666266
Atrioventricular block complete 22.10 11.18 23 250949 8454 29693052
Inflammatory bowel disease 22.06 11.18 55 250917 2238 29699268
Facial paresis 22.00 11.18 63 250909 2787 29698719
Swollen joint count increased 21.98 11.18 11 250961 58 29701448
Ventricular extrasystoles 21.96 11.18 39 250933 11435 29690071
Ventricular fibrillation 21.94 11.18 60 250912 15078 29686428
Flatulence 21.92 11.18 78 250894 18051 29683455
Interstitial lung disease 21.91 11.18 660 250312 59537 29641969
Tuberculous pleurisy 21.85 11.18 21 250951 358 29701148
Psychomotor hyperactivity 21.80 11.18 22 250950 8202 29693304
Angioimmunoblastic T-cell lymphoma stage IV 21.74 11.18 7 250965 7 29701499
Hyperuricaemia 21.71 11.18 18 250954 7376 29694130
JC virus infection 21.68 11.18 47 250925 1743 29699763
Hypothermia 21.68 11.18 29 250943 9538 29691968
Abdominal pain upper 21.65 11.18 381 250591 62170 29639336
Terminal state 21.64 11.18 73 250899 3531 29697975
White blood cell count decreased 21.50 11.18 537 250435 83410 29618096
Bladder transitional cell carcinoma recurrent 21.48 11.18 13 250959 105 29701401
Rheumatoid vasculitis 21.43 11.18 17 250955 221 29701285
Non-alcoholic steatohepatitis 21.42 11.18 29 250943 728 29700778
Synovial disorder 21.38 11.18 13 250959 106 29701400
Glioblastoma multiforme 21.36 11.18 31 250941 832 29700674
Ependymoma malignant 21.35 11.18 8 250964 17 29701489
Cutaneous symptom 21.31 11.18 18 250954 257 29701249
Minimal residual disease 21.30 11.18 17 250955 223 29701283
Chronic graft versus host disease in intestine 21.30 11.18 17 250955 223 29701283
Acute respiratory failure 21.28 11.18 128 250844 25722 29675784
Blood cholesterol increased 21.21 11.18 72 250900 16898 29684608
Epstein-Barr virus antigen positive 21.17 11.18 9 250963 30 29701476
Antithrombin III decreased 21.16 11.18 21 250951 373 29701133
Carcinoma in situ of skin 21.12 11.18 12 250960 85 29701421
Meningitis chemical 21.12 11.18 11 250961 64 29701442
Juvenile melanoma benign 21.12 11.18 11 250961 64 29701442
Tonsil cancer 21.10 11.18 29 250943 739 29700767
Oral surgery 21.09 11.18 25 250947 547 29700959
Atrioventricular block 21.05 11.18 18 250954 7264 29694242
Infective myositis 21.05 11.18 8 250964 18 29701488
No adverse event 21.03 11.18 75 250897 17344 29684162
C-reactive protein decreased 20.93 11.18 43 250929 1535 29699971
Pulmonary arteriopathy 20.84 11.18 11 250961 66 29701440
Micrognathia 20.75 11.18 18 250954 267 29701239
Varicella 20.66 11.18 42 250930 1488 29700018
Gout 20.61 11.18 75 250897 17240 29684266
Dermatitis acneiform 20.54 11.18 11 250961 5678 29695828
Leishmaniasis 20.53 11.18 19 250953 308 29701198
Graft versus host disease in eye 20.42 11.18 16 250956 204 29701302
Osteonecrosis 20.42 11.18 216 250756 15919 29685587
Leukodystrophy 20.34 11.18 6 250966 3 29701503
Meningitis staphylococcal 20.32 11.18 11 250961 70 29701436
Muscle spasticity 20.30 11.18 9 250963 5179 29696327
Bronchopulmonary aspergillosis 20.29 11.18 174 250798 12110 29689396
Thyroid cancer 20.27 11.18 38 250934 1267 29700239
Acute coronary syndrome 20.27 11.18 53 250919 13520 29687986
Pneumonia fungal 20.24 11.18 96 250876 5437 29696069
Cardiac failure chronic 20.22 11.18 12 250960 5851 29695655
Ischaemic cardiomyopathy 20.19 11.18 14 250958 6283 29695223
Soft tissue swelling 20.16 11.18 17 250955 242 29701264
Gastric haemorrhage 20.16 11.18 30 250942 9437 29692069
Muscle swelling 20.16 11.18 20 250952 355 29701151
West Nile viral infection 20.09 11.18 25 250947 576 29700930
Blood alkaline phosphatase increased 20.02 11.18 168 250804 31319 29670187
Skin dystrophy 20.01 11.18 7 250965 11 29701495
Faecaloma 20.01 11.18 6 250966 4399 29697107
Vasculitis 20.00 11.18 125 250847 7865 29693641
Intestinal ischaemia 19.99 11.18 17 250955 6880 29694626
Secondary amyloidosis 19.94 11.18 10 250962 53 29701453
Infectious thyroiditis 19.92 11.18 12 250960 96 29701410
Intentional product use issue 19.92 11.18 422 250550 36018 29665488
Aphthous ulcer 19.88 11.18 78 250894 4063 29697443
Hepatitis B virus test positive 19.85 11.18 16 250956 213 29701293
Pachymeningitis 19.82 11.18 12 250960 97 29701409
Adult T-cell lymphoma/leukaemia 19.77 11.18 17 250955 249 29701257
Steatohepatitis 19.67 11.18 19 250953 326 29701180
Keratitis 19.56 11.18 35 250937 1125 29700381
Face oedema 19.54 11.18 41 250931 11293 29690213
Ophthalmic herpes zoster 19.53 11.18 26 250946 642 29700864
Alopecia 19.46 11.18 247 250725 19028 29682478
Refusal of treatment by patient 19.41 11.18 9 250963 5044 29696462
Stem cell transplant 19.34 11.18 50 250922 2081 29699425
Brain natriuretic peptide increased 19.25 11.18 5 250967 4030 29697476
Liver disorder 19.21 11.18 353 250619 29369 29672137
Peritonitis 19.13 11.18 103 250869 21272 29680234
Nasal cavity cancer 19.11 11.18 13 250959 131 29701375
Iris adhesions 19.10 11.18 15 250957 192 29701314
Acute myeloid leukaemia recurrent 19.09 11.18 41 250931 1511 29699995
Pemphigoid 18.98 11.18 21 250951 7507 29693999
Cerebral infarction 18.98 11.18 136 250836 26237 29675269
Lung neoplasm 18.97 11.18 82 250890 4464 29697042
Epstein-Barr virus test positive 18.96 11.18 23 250949 516 29700990
Heavy chain disease 18.95 11.18 5 250967 0 29701506
Injection site rash 18.93 11.18 69 250903 3470 29698036
Large intestinal stenosis 18.92 11.18 36 250936 1214 29700292
Muscle haemorrhage 18.84 11.18 4 250968 3699 29697807
Mucosal disorder 18.82 11.18 41 250931 1526 29699980
Physical disability 18.78 11.18 34 250938 1103 29700403
Monoclonal B-cell lymphocytosis 18.74 11.18 8 250964 27 29701479
Salivary gland cancer 18.74 11.18 16 250956 232 29701274
Bradyphrenia 18.70 11.18 5 250967 3952 29697554
Morphoea 18.55 11.18 13 250959 138 29701368
Crohn's disease 18.54 11.18 79 250893 4273 29697233
Body temperature fluctuation 18.54 11.18 36 250936 1233 29700273
Small fibre neuropathy 18.53 11.18 8 250964 28 29701478
Product complaint 18.50 11.18 13 250959 5793 29695713
Alveolitis 18.47 11.18 43 250929 1674 29699832
Metastatic bronchial carcinoma 18.35 11.18 15 250957 204 29701302
Thymus enlargement 18.30 11.18 10 250962 65 29701441
Synovectomy 18.30 11.18 10 250962 65 29701441
Burkitt's lymphoma 18.23 11.18 14 250958 173 29701333
Muscle twitching 18.20 11.18 25 250947 8130 29693376
Obsessive-compulsive disorder 18.17 11.18 6 250966 4135 29697371
Nail dystrophy 18.14 11.18 12 250960 115 29701391
Catatonia 18.10 11.18 7 250965 4373 29697133
Meningitis tuberculous 18.09 11.18 23 250949 542 29700964
Musculoskeletal disorder 18.01 11.18 85 250887 4804 29696702
Thirst 17.95 11.18 19 250953 6930 29694576
International normalised ratio decreased 17.90 11.18 8 250964 4582 29696924
Lower respiratory tract infection 17.87 11.18 319 250653 26395 29675111
Blood magnesium decreased 17.84 11.18 12 250960 5471 29696035
Osteolysis 17.81 11.18 40 250932 1520 29699986
Immune recovery uveitis 17.77 11.18 7 250965 18 29701488
Drug dependence 17.77 11.18 105 250867 21190 29680316
Circulatory collapse 17.76 11.18 98 250874 20116 29681390
Rectal haemorrhage 17.74 11.18 197 250775 34742 29666764
Medication error 17.71 11.18 103 250869 20869 29680637
Granulomatosis with polyangiitis 17.58 11.18 29 250943 872 29700634
Pericarditis tuberculous 17.57 11.18 11 250961 95 29701411
Polychondritis 17.52 11.18 13 250959 152 29701354
Sepsis 17.49 11.18 1439 249533 144956 29556550
Autoimmune lymphoproliferative syndrome 17.38 11.18 13 250959 154 29701352
Tooth abscess 17.36 11.18 87 250885 5039 29696467
Somnambulism 17.35 11.18 3 250969 3211 29698295
Cystitis escherichia 17.33 11.18 14 250958 187 29701319
Eye infection toxoplasmal 17.33 11.18 14 250958 187 29701319
Infective tenosynovitis 17.33 11.18 9 250963 52 29701454
Shoulder arthroplasty 17.32 11.18 20 250952 425 29701081
Purulent pericarditis 17.32 11.18 6 250966 9 29701497
Cushingoid 17.32 11.18 53 250919 2434 29699072
Spinal cord disorder 17.30 11.18 24 250948 617 29700889
Neonatal respiratory distress syndrome 17.28 11.18 6 250966 4006 29697500
Hemiparesis 17.28 11.18 195 250777 14607 29686899
Altered state of consciousness 17.27 11.18 97 250875 19822 29681684
Glottis carcinoma 17.25 11.18 7 250965 20 29701486
Cerebrosclerosis 17.25 11.18 7 250965 20 29701486
Rheumatic disorder 17.24 11.18 21 250951 473 29701033
Meningitis enterococcal 17.24 11.18 10 250962 74 29701432
Abdominal discomfort 17.23 11.18 533 250439 48258 29653248
Mediastinal mass 17.17 11.18 13 250959 157 29701349
Ischaemic stroke 17.14 11.18 74 250898 16201 29685305
Palmoplantar pustulosis 17.13 11.18 10 250962 75 29701431
Ligament calcification 17.05 11.18 9 250963 54 29701452
Adenoviral hepatitis 17.04 11.18 13 250959 159 29701347
Injection site pruritus 16.93 11.18 92 250880 5500 29696006
Episcleritis 16.92 11.18 12 250960 130 29701376
Inflammatory myofibroblastic tumour 16.92 11.18 12 250960 130 29701376
Precursor T-lymphoblastic lymphoma/leukaemia 16.92 11.18 10 250962 77 29701429
Haemorrhagic stroke 16.80 11.18 16 250956 6131 29695375
Spinal pain 16.73 11.18 78 250894 4386 29697120
Polyuria 16.71 11.18 22 250950 7284 29694222
Labelled drug-drug interaction medication error 16.63 11.18 40 250932 10498 29691008
Hepatitis E 16.61 11.18 40 250932 1592 29699914
Blood glucose fluctuation 16.61 11.18 5 250967 3656 29697850
Body temperature decreased 16.60 11.18 138 250834 9517 29691989
Hyperfibrinogenaemia 16.59 11.18 6 250966 11 29701495
Cystitis viral 16.54 11.18 20 250952 447 29701059
Pollakiuria 16.53 11.18 79 250893 16827 29684679
Exostosis 16.53 11.18 65 250907 3390 29698116
Cardiomegaly 16.51 11.18 64 250908 14445 29687061
Parkinsonism 16.51 11.18 22 250950 7247 29694259
Meningoencephalitis herpetic 16.49 11.18 26 250946 752 29700754
Activated partial thromboplastin time prolonged 16.48 11.18 25 250947 7803 29693703
Vascular access complication 16.45 11.18 14 250958 202 29701304
Folate deficiency 16.45 11.18 30 250942 979 29700527
Organising pneumonia 16.41 11.18 85 250887 4989 29696517
Strongyloidiasis 16.34 11.18 50 250922 2296 29699210
Erythema multiforme 16.34 11.18 26 250946 7959 29693547
Scab 16.33 11.18 70 250902 3796 29697710
Gastroenteritis Escherichia coli 16.33 11.18 12 250960 138 29701368
Gynaecomastia 16.33 11.18 28 250944 8323 29693183
Amyloidosis 16.24 11.18 47 250925 2092 29699414
Bladder neoplasm 16.22 11.18 32 250940 1109 29700397
Nocturia 16.14 11.18 28 250944 8284 29693222
Hepatic failure 16.09 11.18 195 250777 33848 29667658
Quadriplegia 16.03 11.18 38 250934 1497 29700009
Herpes simplex 16.00 11.18 77 250895 4387 29697119
Iridocyclitis 15.94 11.18 36 250936 1373 29700133
Small cell lung cancer 15.94 11.18 43 250929 1837 29699669
Leukocytosis 15.90 11.18 110 250862 21392 29680114
Blood cholesterol abnormal 15.88 11.18 35 250937 1313 29700193
Electrocardiogram QRS complex prolonged 15.84 11.18 8 250964 4269 29697237
Central nervous system infection 15.84 11.18 20 250952 468 29701038
Cavernous sinus thrombosis 15.76 11.18 11 250961 116 29701390
Anaphylactic shock 15.75 11.18 62 250910 13931 29687575
Systemic candida 15.73 11.18 55 250917 2709 29698797
Infective aneurysm 15.72 11.18 18 250954 379 29701127
Meningitis aseptic 15.72 11.18 49 250923 2273 29699233
Gastrointestinal inflammation 15.69 11.18 57 250915 2862 29698644
Cauda equina syndrome 15.68 11.18 18 250954 380 29701126
Thrombosis in device 15.66 11.18 5 250967 3521 29697985
Silicosis 15.64 11.18 6 250966 14 29701492
Dysplastic naevus syndrome 15.64 11.18 6 250966 14 29701492
Cutaneous tuberculosis 15.54 11.18 10 250962 91 29701415
Arthroscopy 15.54 11.18 10 250962 91 29701415
Bladder neck operation 15.53 11.18 5 250967 5 29701501
Sudden cardiac death 15.50 11.18 6 250966 3746 29697760
Trichosporon infection 15.50 11.18 23 250949 630 29700876
Mucosal necrosis 15.47 11.18 9 250963 67 29701439
Ketoacidosis 15.46 11.18 6 250966 3740 29697766
Hepatic candidiasis 15.43 11.18 8 250964 46 29701460
Body height decreased 15.38 11.18 6 250966 3728 29697778
B-cell lymphoma stage IV 15.36 11.18 9 250963 68 29701438
Electrocardiogram abnormal 15.34 11.18 16 250956 5876 29695630
Legionella infection 15.32 11.18 18 250954 390 29701116
IVth nerve paralysis 15.29 11.18 8 250964 47 29701459
Malignant melanoma stage I 15.27 11.18 10 250962 94 29701412
Neutrophil count decreased 15.20 11.18 257 250715 42197 29659309
Oral toxicity 15.16 11.18 4 250968 0 29701506
Fear-related avoidance of activities 15.16 11.18 4 250968 0 29701506
Blood testosterone decreased 15.15 11.18 9 250963 4387 29697119
Localised infection 15.15 11.18 179 250793 13558 29687948
CNS ventriculitis 15.13 11.18 14 250958 227 29701279
Post lumbar puncture syndrome 15.12 11.18 12 250960 156 29701350
Tinea versicolour 15.12 11.18 12 250960 156 29701350
Graft versus host disease in lung 15.08 11.18 20 250952 492 29701014
Injection site warmth 15.06 11.18 41 250931 1761 29699745
Superior mesenteric artery syndrome 15.05 11.18 9 250963 71 29701435
Escherichia bacteraemia 15.03 11.18 56 250916 2846 29698660
Palindromic rheumatism 15.03 11.18 13 250959 192 29701314
Injection site reaction 15.03 11.18 147 250825 10613 29690893
Haematopoietic neoplasm 15.03 11.18 8 250964 49 29701457
Meningitis 14.98 11.18 77 250895 4505 29697001
Asphyxia 14.97 11.18 14 250958 5411 29696095
Visual acuity reduced 14.94 11.18 75 250897 15771 29685735
Intestinal atresia 14.94 11.18 9 250963 72 29701434
Swelling face 14.94 11.18 110 250862 21094 29680412
Respiratory tract infection 14.94 11.18 197 250775 15309 29686197
Tonsillar ulcer 14.92 11.18 13 250959 194 29701312
Mental disorder 14.88 11.18 60 250912 13389 29688117
Splenic lesion 14.87 11.18 11 250961 128 29701378
International normalised ratio abnormal 14.82 11.18 4 250968 3142 29698364
Protein urine present 14.81 11.18 11 250961 4764 29696742
Pseudomonal sepsis 14.81 11.18 57 250915 2943 29698563
Syringe issue 14.77 11.18 3 250969 2862 29698644
Product administration error 14.76 11.18 66 250906 14311 29687195
Pharyngitis 14.68 11.18 103 250869 6739 29694767
Temporal lobe epilepsy 14.66 11.18 11 250961 131 29701375
Nail psoriasis 14.64 11.18 8 250964 52 29701454
Testicular seminoma (pure) 14.64 11.18 8 250964 52 29701454
Panniculitis 14.64 11.18 26 250946 831 29700675
Coma scale abnormal 14.62 11.18 5 250967 3371 29698135
Transfusion 14.61 11.18 25 250947 7436 29694070
Joint abscess 14.60 11.18 10 250962 102 29701404
Intracranial pressure increased 14.60 11.18 63 250909 3427 29698079
Intestinal stenosis 14.60 11.18 42 250930 1863 29699643
Diverticular perforation 14.58 11.18 59 250913 3118 29698388
Pharyngeal inflammation 14.54 11.18 16 250956 322 29701184
Inflammatory pain 14.52 11.18 8 250964 53 29701453
Extranodal marginal zone B-cell lymphoma (MALT type) 14.51 11.18 12 250960 166 29701340
Euphoric mood 14.48 11.18 9 250963 4281 29697225
Coccidioidomycosis 14.47 11.18 22 250950 616 29700890
Adverse reaction 14.47 11.18 55 250917 2823 29698683
Crystal nephropathy 14.45 11.18 17 250955 369 29701137
Hepatosplenic candidiasis 14.39 11.18 13 250959 204 29701302
Post procedural infection 14.38 11.18 76 250896 4496 29697010
Anal squamous cell carcinoma 14.35 11.18 9 250963 78 29701428
Encephalitis Japanese B 14.34 11.18 6 250966 19 29701487
Spinal cord oedema 14.34 11.18 12 250960 169 29701337
Body mass index abnormal 14.26 11.18 9 250963 79 29701427
Tongue neoplasm 14.24 11.18 5 250967 8 29701498
Cytopenia 14.20 11.18 118 250854 8138 29693368
Mucosal ulceration 14.18 11.18 26 250946 852 29700654
Bursa disorder 14.17 11.18 12 250960 172 29701334
Impaired quality of life 14.16 11.18 36 250936 1483 29700023
Injection site irritation 14.14 11.18 28 250944 973 29700533
Osteomyelitis salmonella 14.13 11.18 7 250965 36 29701470
Myocardial ischaemia 14.12 11.18 86 250886 17231 29684275
Abscess sterile 14.11 11.18 6 250966 20 29701486
Chronic actinic dermatitis 14.11 11.18 6 250966 20 29701486
Brain abscess 14.11 11.18 52 250920 2629 29698877
Escherichia infection 14.09 11.18 97 250875 6308 29695198
Skin infection 14.08 11.18 94 250878 6050 29695456
Staphylococcal bacteraemia 14.01 11.18 101 250871 6667 29694839
Lip swelling 14.01 11.18 57 250915 12687 29688819
Anal inflammation 14.01 11.18 16 250956 336 29701170
Cartilage injury 14.00 11.18 18 250954 429 29701077
Hepatocellular carcinoma 13.99 11.18 38 250934 9572 29691934
Pulmonary nocardiosis 13.99 11.18 17 250955 382 29701124
Prostate infection 13.98 11.18 23 250949 690 29700816
Acute pulmonary oedema 13.97 11.18 26 250946 7489 29694017
Granuloma 13.97 11.18 48 250924 2344 29699162
Respiratory acidosis 13.93 11.18 9 250963 4193 29697313
Subcutaneous abscess 13.92 11.18 62 250910 3419 29698087
Human herpesvirus 6 infection 13.89 11.18 42 250930 1916 29699590
Bronchoalveolar lavage abnormal 13.89 11.18 9 250963 83 29701423
CSF myelin basic protein increased 13.88 11.18 5 250967 9 29701497
Lymphopenia 13.85 11.18 170 250802 12993 29688513
Cerebral toxoplasmosis 13.84 11.18 35 250937 1437 29700069
Neurological decompensation 13.84 11.18 47 250925 2281 29699225
Endocarditis bacterial 13.83 11.18 25 250947 810 29700696
Coordination abnormal 13.83 11.18 25 250947 7280 29694226
Spinal cord abscess 13.79 11.18 13 250959 216 29701290
Renal failure 13.78 11.18 913 250059 128053 29573453
Urine output decreased 13.77 11.18 39 250933 9690 29691816
Transplant rejection 13.71 11.18 36 250936 9170 29692336
Renal cell carcinoma 13.69 11.18 89 250883 5677 29695829
HLA-B*27 positive 13.68 11.18 6 250966 22 29701484
Meningitis viral 13.67 11.18 23 250949 703 29700803
Nephrogenic systemic fibrosis 13.65 11.18 10 250962 4361 29697145
Bone abscess 13.62 11.18 11 250961 147 29701359
Diffuse large B-cell lymphoma stage III 13.60 11.18 8 250964 61 29701445
Hyperlipidaemia 13.59 11.18 65 250907 13842 29687664
Solar urticaria 13.54 11.18 5 250967 10 29701496
Oropharyngitis fungal 13.54 11.18 5 250967 10 29701496
Meningitis noninfective 13.54 11.18 5 250967 10 29701496
Oesophageal squamous cell carcinoma 13.53 11.18 16 250956 349 29701157
Rebound effect 13.53 11.18 36 250936 1525 29699981
Double stranded DNULL antibody 13.48 11.18 6 250966 23 29701483
Restless legs syndrome 13.48 11.18 23 250949 6849 29694657
Stupor 13.46 11.18 4 250968 2949 29698557
Intestinal fibrosis 13.45 11.18 9 250963 88 29701418
Hypothyroidism 13.45 11.18 72 250900 14891 29686615
Chronic graft versus host disease in liver 13.44 11.18 14 250958 264 29701242
VIth nerve paralysis 13.42 11.18 23 250949 714 29700792
Nervousness 13.42 11.18 52 250920 11736 29689770
Azotaemia 13.41 11.18 13 250959 4939 29696567
Gallbladder oedema 13.40 11.18 12 250960 186 29701320
Malignant melanoma in situ 13.37 11.18 27 250945 952 29700554
Ankle operation 13.37 11.18 13 250959 225 29701281
Diffuse large B-cell lymphoma stage IV 13.37 11.18 13 250959 225 29701281
Atypical mycobacterial infection 13.36 11.18 24 250948 774 29700732
Investigation abnormal 13.36 11.18 16 250956 354 29701152
Dermatitis psoriasiform 13.34 11.18 30 250942 1141 29700365
Bacterial infection 13.33 11.18 163 250809 12447 29689059
Myeloid leukaemia 13.32 11.18 16 250956 355 29701151
Pneumonitis chemical 13.31 11.18 11 250961 152 29701354
Cardiac murmur 13.29 11.18 23 250949 6811 29694695
Left ventricular hypertrophy 13.27 11.18 20 250952 6258 29695248
Personality change due to a general medical condition 13.26 11.18 7 250965 42 29701464
Conus medullaris syndrome 13.23 11.18 5 250967 11 29701495
Echinococciasis 13.23 11.18 5 250967 11 29701495
Bone tuberculosis 13.21 11.18 15 250957 313 29701193
Hyperthermia 13.20 11.18 42 250930 10057 29691449
Neoplasm recurrence 13.20 11.18 40 250932 1827 29699679
Q fever 13.19 11.18 10 250962 121 29701385
Capnocytophaga infection 13 11.18 7 250965 44 29701462
Elbow operation 12.99 11.18 10 250962 124 29701382
Haemodynamic instability 12.99 11.18 30 250942 7985 29693521
Pityriasis rubra pilaris 12.98 11.18 8 250964 67 29701439
Respiratory failure 12.97 11.18 700 250272 99942 29601564
Arteriospasm coronary 12.97 11.18 3 250969 2615 29698891
Pleomorphic malignant fibrous histiocytoma 12.95 11.18 4 250968 3 29701503
Ear canal stenosis 12.93 11.18 5 250967 12 29701494
Rhinocerebral mucormycosis 12.88 11.18 8 250964 68 29701438
Dyspnoea at rest 12.88 11.18 3 250969 2603 29698903
Ammonia increased 12.86 11.18 10 250962 4231 29697275
Herpes ophthalmic 12.85 11.18 17 250955 417 29701089
Mitral valve incompetence 12.85 11.18 62 250910 13172 29688334
Blood triglycerides increased 12.85 11.18 67 250905 13950 29687556
Dialysis 12.84 11.18 48 250924 10948 29690558
Electrocardiogram ST segment elevation 12.81 11.18 11 250961 4431 29697075
Dysarthria 12.81 11.18 179 250793 30311 29671195
Medulloblastoma recurrent 12.79 11.18 8 250964 69 29701437
Cyst rupture 12.79 11.18 8 250964 69 29701437
Tender joint count increased 12.74 11.18 6 250966 27 29701479
Desmoid tumour 12.73 11.18 9 250963 97 29701409
Immobile 12.71 11.18 43 250929 2083 29699423
Superficial spreading melanoma stage unspecified 12.69 11.18 11 250961 163 29701343
Suspected product quality issue 12.69 11.18 11 250961 163 29701343
Faecal calprotectin abnormal 12.69 11.18 11 250961 163 29701343
Amyotrophic lateral sclerosis 12.68 11.18 27 250945 989 29700517
Lung abscess 12.63 11.18 48 250924 2463 29699043
Stress ulcer 12.60 11.18 8 250964 71 29701435
Listeriosis 12.58 11.18 25 250947 871 29700635
Pancreatic neoplasm 12.57 11.18 26 250946 933 29700573
Hypovolaemic shock 12.52 11.18 22 250950 6478 29695028
Alcohol use 12.51 11.18 8 250964 3747 29697759
Product storage error 12.45 11.18 94 250878 6297 29695209
Diabetic neuropathy 12.43 11.18 9 250963 3950 29697556
Acanthosis 12.42 11.18 8 250964 73 29701433
Terminal ileitis 12.40 11.18 6 250966 29 29701477
Antinuclear antibody positive 12.39 11.18 33 250939 1399 29700107
Pneumatosis intestinalis 12.38 11.18 50 250922 2640 29698866
Urinary incontinence 12.36 11.18 87 250885 16853 29684653
Drug use disorder 12.36 11.18 57 250915 3191 29698315
Enzyme level increased 12.36 11.18 10 250962 134 29701372
Retroperitoneal haematoma 12.35 11.18 3 250969 2529 29698977
Blood culture positive 12.34 11.18 77 250895 4842 29696664
Viral vasculitis 12.33 11.18 8 250964 74 29701432
Rheumatoid factor 12.33 11.18 8 250964 74 29701432
Pulmonary air leakage 12.29 11.18 9 250963 103 29701403
Herpes virus infection 12.28 11.18 48 250924 2496 29699010
Cardiac failure acute 12.25 11.18 38 250934 9171 29692335
Extrapulmonary tuberculosis 12.21 11.18 9 250963 104 29701402
Rocky mountain spotted fever 12.15 11.18 5 250967 15 29701491
Device leakage 12.13 11.18 8 250964 3686 29697820
Gastric cancer 12.12 11.18 77 250895 4873 29696633
Vitreous floaters 12.12 11.18 6 250966 3238 29698268
Poikiloderma 12.11 11.18 11 250961 174 29701332
Disseminated toxoplasmosis 12.09 11.18 6 250966 31 29701475
Surgery 12.08 11.18 149 250823 11402 29690104
Arthritis fungal 12.06 11.18 8 250964 77 29701429
Parakeratosis 12.06 11.18 10 250962 139 29701367
Muscle enzyme increased 12.05 11.18 12 250960 214 29701292
Cerebral haematoma 12.05 11.18 12 250960 4502 29697004
Bradykinesia 12.03 11.18 6 250966 3224 29698282
Pseudolymphoma 12.02 11.18 18 250954 497 29701009
Mood swings 11.99 11.18 29 250943 7597 29693909
Peritonsillar abscess 11.96 11.18 14 250958 302 29701204
Anaplastic large-cell lymphoma 11.95 11.18 11 250961 177 29701329
Pulmonary arterial hypertension 11.94 11.18 39 250933 9262 29692244
Soft tissue infection 11.93 11.18 35 250937 1570 29699936
Mesenteritis 11.91 11.18 5 250967 16 29701490
Vaccination complication 11.91 11.18 5 250967 16 29701490
Laryngeal inflammation 11.91 11.18 5 250967 16 29701490
C-reactive protein 11.87 11.18 9 250963 109 29701397
Fusarium infection 11.83 11.18 27 250945 1037 29700469
Prostatic specific antigen increased 11.79 11.18 56 250916 11948 29689558
Nail injury 11.79 11.18 6 250966 33 29701473
Pelvic cyst 11.79 11.18 6 250966 33 29701473
Psoriasis area severity index increased 11.79 11.18 6 250966 33 29701473
Mediastinal abscess 11.79 11.18 6 250966 33 29701473
Skin injury 11.77 11.18 26 250946 977 29700529
Encephalitis fungal 11.76 11.18 11 250961 181 29701325
Inadequate analgesia 11.75 11.18 4 250968 2704 29698802
Growth failure 11.73 11.18 7 250965 55 29701451
Conjunctival haemorrhage 11.69 11.18 4 250968 2696 29698810
Pathogen resistance 11.69 11.18 34 250938 8376 29693130
Antiphospholipid syndrome 11.69 11.18 16 250956 406 29701100
Electrolyte imbalance 11.68 11.18 53 250919 11447 29690059
Coronary artery stenosis 11.66 11.18 38 250934 9032 29692474
Oral pustule 11.66 11.18 12 250960 223 29701283
Bowen's disease 11.66 11.18 10 250962 146 29701360
Renal colic 11.63 11.18 37 250935 1735 29699771
Skin toxicity 11.62 11.18 56 250916 3193 29698313
Blood beta-D-glucan increased 11.61 11.18 17 250955 460 29701046
Device deployment issue 11.60 11.18 9 250963 113 29701393
Lower respiratory tract congestion 11.59 11.18 26 250946 987 29700519
Hypersomnia 11.58 11.18 52 250920 11264 29690242
Cryptococcal fungaemia 11.57 11.18 8 250964 83 29701423
Oesophageal adenocarcinoma 11.57 11.18 24 250948 863 29700643
Bundle branch block left 11.57 11.18 16 250956 5188 29696318
Arteriosclerosis 11.56 11.18 49 250923 10784 29690722
Intestinal transit time decreased 11.55 11.18 4 250968 6 29701500
Cyanosis 11.54 11.18 56 250916 11879 29689627
Ureaplasma infection 11.52 11.18 11 250961 186 29701320
Pneumoconiosis 11.49 11.18 13 250959 270 29701236
Abscess intestinal 11.49 11.18 32 250940 1393 29700113
Cell marker increased 11.47 11.18 17 250955 465 29701041
Tonsillitis bacterial 11.47 11.18 5 250967 18 29701488
Gastric mucosal hypertrophy 11.41 11.18 8 250964 85 29701421
Bladder cancer recurrent 11.37 11.18 14 250958 319 29701187
Herpes simplex viraemia 11.37 11.18 3 250969 0 29701506
Bone callus excessive 11.37 11.18 3 250969 0 29701506
Chronic tonsillitis 11.37 11.18 3 250969 0 29701506
Bronchitis fungal 11.37 11.18 3 250969 0 29701506
Papillary tumour of renal pelvis 11.37 11.18 3 250969 0 29701506
Hepatitis B e antibody positive 11.37 11.18 3 250969 0 29701506
Acute lymphocytic leukaemia (in remission) 11.37 11.18 3 250969 0 29701506
Vascular wall hypertrophy 11.37 11.18 3 250969 0 29701506
Lymphadenitis 11.37 11.18 36 250936 1684 29699822
Chromosomal deletion 11.37 11.18 6 250966 36 29701470
Coronary arterial stent insertion 11.37 11.18 11 250961 4183 29697323
Mucosal infection 11.36 11.18 12 250960 230 29701276
Systemic lupus erythematosus 11.36 11.18 47 250925 2509 29698997
Oxygen saturation decreased 11.35 11.18 277 250695 43163 29658343
Chills 11.31 11.18 493 250479 71845 29629661
Renal tubular necrosis 11.29 11.18 78 250894 15173 29686333
Hepatosplenomegaly 11.28 11.18 61 250911 3640 29697866
Pneumonia adenoviral 11.28 11.18 10 250962 153 29701353
Candida osteomyelitis 11.27 11.18 5 250967 19 29701487
Hypotonia 11.26 11.18 26 250946 6922 29694584
Hip deformity 11.26 11.18 8 250964 87 29701419
SARS-CoV-2 test negative 11.24 11.18 6 250966 37 29701469
Pancreatic calcification 11.24 11.18 11 250961 192 29701314
Eye irritation 11.23 11.18 19 250953 5677 29695829
Extramedullary haemopoiesis 11.22 11.18 7 250965 60 29701446
Tuberculosis liver 11.22 11.18 7 250965 60 29701446
Encephalitis enteroviral 11.22 11.18 10 250962 154 29701352
Anaplastic large cell lymphoma T- and null-cell types 11.22 11.18 9 250963 119 29701387
Infected dermal cyst 11.22 11.18 15 250957 372 29701134

Pharmacologic Action:

SourceCodeDescription
ATC L01BA01 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
ANTIMETABOLITES
Folic acid analogues
ATC L04AX03 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
IMMUNOSUPPRESSANTS
IMMUNOSUPPRESSANTS
Other immunosuppressants
MeSH PA D000019 Abortifacient Agents
MeSH PA D000020 Abortifacient Agents, Nonsteroidal
MeSH PA D000963 Antimetabolites
MeSH PA D000964 Antimetabolites, Antineoplastic
MeSH PA D000970 Antineoplastic Agents
MeSH PA D018501 Antirheumatic Agents
MeSH PA D003879 Dermatologic Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D005493 Folic Acid Antagonists
MeSH PA D007155 Immunologic Factors
MeSH PA D007166 Immunosuppressive Agents
MeSH PA D009676 Noxae
MeSH PA D019384 Nucleic Acid Synthesis Inhibitors
MeSH PA D012102 Reproductive Control Agents
FDA MoA N0000000111 Folic Acid Metabolism Inhibitors
FDA EPC N0000175584 Folate Analog Metabolic Inhibitor
CHEBI has role CHEBI:35221 antimetabolite
CHEBI has role CHEBI:35610 cytostatic
CHEBI has role CHEBI:35705 immunosuppressant
CHEBI has role CHEBI:35842 antirheumatic agent
CHEBI has role CHEBI:50177 dermatological agent
CHEBI has role CHEBI:50683 7,8-dihydrofolate reductase inhibitors
CHEBI has role CHEBI:50691 abortifacient agent
CHEBI has role CHEBI:59517 dna synthesis inhibitors

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Psoriasis indication 9014002 DOID:8893
Rheumatoid arthritis indication 69896004 DOID:7148
Acute lymphoid leukemia indication 91857003 DOID:9952
Non-Hodgkin's lymphoma indication 118601006
Burkitt's lymphoma indication 118617000
Mycosis fungoides indication 118618005
Malignant tumor of head and/or neck indication 255056009
Osteosarcoma of bone indication 307576001 DOID:3376
Malignant tumor of lung indication 363358000
Juvenile rheumatoid arthritis indication 410795001
Carcinoma of female breast indication 447782002
Gestational trophoblastic neoplasia indication 609519004 DOID:3590
Meningeal Leukemia indication
Polymyositis off-label use 31384009
Vasculitis off-label use 31996006 DOID:865
Psoriasis with arthropathy off-label use 33339001
Systemic lupus erythematosus off-label use 55464009 DOID:9074
Acute myeloid leukemia, disease off-label use 91861009
Acute promyelocytic leukemia, FAB M3 off-label use 110004001
Wegener's granulomatosis off-label use 195353004 DOID:12132
Malignant tumor of urinary bladder off-label use 399326009 DOID:11054
Systemic Dermatomyositis off-label use
Alcoholism contraindication 7200002
Peptic ulcer contraindication 13200003 DOID:750
Dehydration contraindication 34095006
Fibrosis of lung contraindication 51615001 DOID:3770
Acute nephropathy contraindication 58574008
Hepatic failure contraindication 59927004
Stomatitis contraindication 61170000 DOID:9637
Interstitial pneumonia contraindication 64667001
Ulcerative colitis contraindication 64766004 DOID:8577
Leukopenia contraindication 84828003 DOID:615
Kidney disease contraindication 90708001 DOID:557
Disease of liver contraindication 235856003 DOID:409
Anemia contraindication 271737000 DOID:2355
Pregnancy, function contraindication 289908002
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Bone marrow depression contraindication 307762000
Ascites contraindication 389026000
Gastric ulcer contraindication 397825006 DOID:10808
Breastfeeding (mother) contraindication 413712001
Disorder of immune function contraindication 414029004
Methotrexate Toxicity contraindication
Pleural Effusions contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.61 acidic
pKa2 5.15 acidic
pKa3 12.92 acidic
pKa4 5.73 Basic
pKa5 4.51 Basic
pKa6 1.39 Basic
pKa7 0.75 Basic
pKa8 0.08 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
EQ 2.5MG BASE/ML XATMEP AZURITY N208400 April 25, 2017 RX SOLUTION ORAL April 25, 2024 TREATMENT OF OLIGOARTICULAR JUVENILE IDIOPATHIC ARTHRITIS (PERSISTENT OLIGOARTHRITIS, PSORIATIC JUVENILE IDIOPATHIC ARTHRITIS, ENTHESITIS-RELATED ARTHRITIS, OR UNDIFFERENTIATED ARTHRITIS) & POLYARTICULAR JUVENILE IDIOPATHIC ARTHRITIS IN CHILDREN 0-16 YRS
EQ 2.5MG BASE/ML XATMEP AZURITY N208400 April 25, 2017 RX SOLUTION ORAL April 25, 2024 TREATMENT OF PEDIATRIC PATIENTS WITH ACUTE LYMPHOBLASTIC LEUKEMIA AS A COMPONENT OF A COMBINULLTION CHEOMOTHERAPY MAINTENULLNCE REGIMEN

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Dihydrofolate reductase Enzyme INHIBITOR Ki 8.92 IUPHAR DRUG LABEL
Multidrug resistance-associated protein 4 Transporter WOMBAT-PK
Multidrug resistance-associated protein 5 Transporter WOMBAT-PK
ATP-binding cassette sub-family G member 2 Transporter WOMBAT-PK
Multidrug resistance-associated protein 1 Transporter WOMBAT-PK
Canalicular multispecific organic anion transporter 1 Transporter WOMBAT-PK
Multidrug resistance protein 1 Transporter WOMBAT-PK
Thymidylate synthase Enzyme Ki 6.22 CHEMBL
Folylpolyglutamate synthase, mitochondrial Enzyme IC50 5.49 CHEMBL
Folate transporter 1 Unclassified Ki 5.46 CHEMBL
Folate receptor alpha Membrane receptor IC50 6.94 CHEMBL
Proton-coupled folate transporter Transporter IC50 6.92 CHEMBL
Folate receptor beta Membrane receptor IC50 6.97 CHEMBL
Dihydrofolate reductase Enzyme IC50 9 CHEMBL
Dihydrofolate reductase Enzyme IC50 8.89 CHEMBL
Bifunctional dihydrofolate reductase-thymidylate synthase Enzyme IC50 8.85 CHEMBL
Bifunctional dihydrofolate reductase-thymidylate synthase Enzyme Ki 9.89 CHEMBL
Thymidylate synthase Enzyme IC50 5.74 CHEMBL
Dihydrofolate reductase Unclassified IC50 8.85 CHEMBL
Thymidylate synthase Enzyme IC50 4.40 CHEMBL
Dihydrofolate reductase Unclassified IC50 8.77 CHEMBL
Dihydrofolate reductase Enzyme Ki 10.14 CHEMBL
Dihydrofolate reductase Enzyme IC50 7.91 CHEMBL
Dihydrofolate reductase Unclassified Ki 10.68 CHEMBL
Thymidylate synthase Enzyme Ki 4.35 CHEMBL
Dihydrofolate reductase Enzyme Ki 5.41 CHEMBL
Dihydrofolate reductase Enzyme IC50 7.72 CHEMBL
Pteridine reductase 1 Enzyme Ki 7.41 CHEMBL

External reference:

IDSource
4019828 VUID
N0000147916 NUI
D00142 KEGG_DRUG
7413-34-5 SECONDARY_CAS_RN
4017903 VANDF
4019828 VANDF
C0025677 UMLSCUI
CHEBI:44185 CHEBI
MTX PDB_CHEM_ID
CHEMBL34259 ChEMBL_ID
CHEMBL426 ChEMBL_ID
CHEMBL3244648 ChEMBL_ID
DB00563 DRUGBANK_ID
4112 PUBCHEM_CID
D008727 MESH_DESCRIPTOR_UI
4815 IUPHAR_LIGAND_ID
926 INN_ID
YL5FZ2Y5U1 UNII
287734 RXNORM
12261 MMSL
30391 MMSL
5077 MMSL
6313 MMSL
73119 MMSL
d00060 MMSL
002644 NDDF
002645 NDDF
387381009 SNOMEDCT_US
412247000 SNOMEDCT_US
68887009 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Methotrexate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0054-4550 TABLET 2.50 mg ORAL ANDA 28 sections
Methotrexate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0054-8550 TABLET 2.50 mg ORAL ANDA 28 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 0143-9367 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 1 g INTRA-ARTERIAL ANDA 23 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 0143-9516 SOLUTION 25 mg INTRA-ARTERIAL ANDA 23 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 0143-9517 SOLUTION 25 mg INTRA-ARTERIAL ANDA 23 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 0143-9518 SOLUTION 25 mg INTRA-ARTERIAL ANDA 23 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 0143-9519 SOLUTION 25 mg INTRA-ARTERIAL ANDA 23 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 0143-9830 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 1 g INTRA-ARTERIAL ANDA 23 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 0378-0014 TABLET 2.50 mg ORAL ANDA 28 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 0555-0572 TABLET 2.50 mg ORAL ANDA 28 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 0703-3671 INJECTION, SOLUTION 25 mg INTRA-ARTERIAL ANDA 28 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 0703-3675 INJECTION, SOLUTION 25 mg INTRA-ARTERIAL ANDA 28 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 0703-3678 INJECTION, SOLUTION 25 mg INTRA-ARTERIAL ANDA 25 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 0703-3678 INJECTION, SOLUTION 25 mg INTRA-ARTERIAL ANDA 25 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 0904-7141 TABLET 2.50 mg ORAL ANDA 26 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 16729-277 INJECTION 25 mg INTRA-ARTERIAL ANDA 29 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 16729-486 TABLET 2.50 mg ORAL ANDA 30 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 42291-505 TABLET 2.50 mg ORAL ANDA 28 sections
Methotrexate Human Prescription Drug Label 1 47335-235 TABLET 2.50 mg ORAL ANDA 30 sections
Methotrexate Human Prescription Drug Label 1 50090-3418 TABLET 2.50 mg ORAL ANDA 30 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 50090-5457 TABLET 2.50 mg ORAL ANDA 28 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 50268-527 TABLET 2.50 mg ORAL ANDA 28 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 51079-670 TABLET 2.50 mg ORAL ANDA 25 sections
Trexall HUMAN PRESCRIPTION DRUG LABEL 1 51285-366 TABLET, FILM COATED 5 mg ORAL ANDA 28 sections
Trexall HUMAN PRESCRIPTION DRUG LABEL 1 51285-367 TABLET, FILM COATED 7.50 mg ORAL ANDA 28 sections
Trexall HUMAN PRESCRIPTION DRUG LABEL 1 51285-368 TABLET, FILM COATED 10 mg ORAL ANDA 28 sections
Trexall HUMAN PRESCRIPTION DRUG LABEL 1 51285-369 TABLET, FILM COATED 15 mg ORAL ANDA 28 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 51407-121 TABLET 2.50 mg ORAL ANDA 29 sections
Xatmep HUMAN PRESCRIPTION DRUG LABEL 1 52652-2001 SOLUTION 2.50 mg ORAL NDA 28 sections
Otrexup HUMAN PRESCRIPTION DRUG LABEL 1 54436-010 INJECTION, SOLUTION 10 mg SUBCUTANEOUS NDA 30 sections