methotrexate ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
folic acid analogues 1751 59-05-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • methotrexate
  • methotrexate sodium
  • amethopterin
  • amethopterine
  • L-Amethopterin
  • ledertrexate
  • metatrexan
  • methoxtrexate
  • methylaminopterin
An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.
  • Molecular weight: 454.45
  • Formula: C20H22N8O5
  • CLOGP: -0.03
  • LIPINSKI: 1
  • HAC: 13
  • HDO: 5
  • TPSA: 210.54
  • ALOGS: -3.42
  • ROTB: 9

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
2.50 mg O
2.50 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.17 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 81 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 1.10 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 33 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.43 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 2.10 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.37 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 3.90 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
March 26, 2019 PMDA PFIZER JAPAN INC.
Dec. 7, 1953 FDA DAVA PHARMS INC
Aug. 18, 2016 EMA Nordic Group B.V.

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 13551.10 11.95 41090 948231 1003675 61496026
Drug intolerance 4557.13 11.95 12786 976535 295875 62203826
Treatment failure 3451.09 11.95 8758 980563 190285 62309416
Joint swelling 2839.18 11.95 11346 977975 316320 62183381
Arthralgia 2410.20 11.95 16136 973185 553574 61946127
Death 2184.75 11.95 1591 987730 372790 62126911
Therapeutic product effect incomplete 2159.75 11.95 5498 983823 119558 62380143
Drug hypersensitivity 2133.03 11.95 10033 979288 300654 62199047
Completed suicide 2087.30 11.95 36 989285 145637 62354064
Contraindicated product administered 1924.63 11.95 7590 981731 210058 62289643
Therapeutic product effect decreased 1880.68 11.95 6947 982374 186240 62313461
Rheumatoid arthritis 1775.45 11.95 8244 981077 245575 62254126
Synovitis 1715.92 11.95 6597 982724 180321 62319380
Musculoskeletal stiffness 1382.00 11.95 6120 983201 178498 62321203
Constipation 1221.78 11.95 1026 988295 223917 62275784
Lymphoproliferative disorder 1214.60 11.95 705 988616 2485 62497216
Liver function test increased 1213.17 11.95 1980 987341 30831 62468870
Arthropathy 1024.85 11.95 6713 982608 228079 62271622
Hypotension 1024.01 11.95 1668 987653 270936 62228765
Alopecia 942.99 11.95 8698 980623 328838 62170863
Acute kidney injury 941.27 11.95 1664 987657 261751 62237950
Dyspnoea 904.65 11.95 6317 983004 654996 61844705
Dehydration 857.55 11.95 861 988460 172493 62327208
Intentional overdose 838.89 11.95 89 989232 74063 62425638
Pain 807.22 11.95 16087 973234 724541 61775160
Hyponatraemia 802.60 11.95 369 988952 111531 62388170
Somnolence 792.13 11.95 971 988350 177714 62321987
Drug abuse 790.50 11.95 99 989222 72419 62427282
Psoriasis 743.18 11.95 3003 986318 83954 62415747
Psoriatic arthropathy 702.13 11.95 3058 986263 88462 62411239
Anaemia 699.45 11.95 2293 987028 291137 62208564
Arthritis 695.48 11.95 3607 985714 112314 62387387
Dizziness 686.78 11.95 3912 985409 426013 62073688
Infection 673.91 11.95 5974 983347 223199 62276502
C-reactive protein increased 649.22 11.95 3061 986260 91646 62408055
Electrocardiogram QT prolonged 644.65 11.95 83 989238 59447 62440254
Bradycardia 634.68 11.95 177 989144 73050 62426651
Swelling 623.03 11.95 6796 982525 268582 62231119
Hepatic enzyme increased 613.80 11.95 5311 984010 197017 62302684
Tremor 612.29 11.95 694 988627 131545 62368156
Abdominal discomfort 611.90 11.95 7662 981659 313223 62186478
Mouth ulceration 610.35 11.95 1490 987831 31494 62468207
Cardiac arrest 609.99 11.95 341 988980 92204 62407497
Multiple sclerosis relapse 604.06 11.95 38 989283 48440 62451261
C-reactive protein abnormal 591.92 11.95 1821 987500 44275 62455426
Red blood cell sedimentation rate increased 587.75 11.95 1762 987559 42220 62457481
Overdose 553.66 11.95 585 988736 114493 62385208
Condition aggravated 552.95 11.95 9068 980253 393149 62106552
Hyperkalaemia 551.16 11.95 91 989230 54112 62445589
Red blood cell sedimentation rate abnormal 540.54 11.95 1046 988275 18736 62480965
Toxicity to various agents 536.68 11.95 2010 987311 245240 62254461
Diarrhoea 521.02 11.95 7933 981388 707433 61792268
Pancytopenia 519.55 11.95 2925 986396 94008 62405693
Anxiety 519.41 11.95 1698 987623 215843 62283858
Cardio-respiratory arrest 517.62 11.95 146 989175 59813 62439888
Depressed level of consciousness 509.07 11.95 166 989155 61912 62437789
Device expulsion 506.85 11.95 7 989314 34915 62464786
Hallucination 491.15 11.95 124 989197 54693 62445008
Inflammation 489.11 11.95 2554 986767 79719 62419982
Drug interaction 486.03 11.95 1880 987441 227251 62272450
Systemic lupus erythematosus 485.16 11.95 5184 984137 203734 62295967
Agitation 484.41 11.95 163 989158 59594 62440107
Suicide attempt 483.76 11.95 172 989149 60746 62438955
Decreased appetite 477.24 11.95 2149 987172 248903 62250798
Gastrointestinal disorder 476.47 11.95 3590 985731 127649 62372052
Sedation 473.04 11.95 34 989287 38775 62460926
Seizure 465.86 11.95 846 988475 131788 62367913
Peripheral swelling 462.41 11.95 6245 983076 259697 62240004
Hypokalaemia 460.92 11.95 563 988758 103241 62396460
Asthenia 457.61 11.95 3802 985519 379802 62119899
Balance disorder 446.92 11.95 394 988927 84028 62415673
Malignant neoplasm progression 446.02 11.95 374 988947 81747 62417954
Joint stiffness 441.47 11.95 1547 987774 40322 62459379
Loss of personal independence in daily activities 439.67 11.95 2808 986513 94482 62405219
Fall 435.36 11.95 3962 985359 388372 62111329
Product dose omission issue 426.77 11.95 2037 987284 232276 62267425
Osteoarthritis 425.43 11.95 2743 986578 92600 62407101
Rhabdomyolysis 418.54 11.95 87 989234 43864 62455837
Hypoglycaemia 418.41 11.95 206 989115 59859 62439842
International normalised ratio increased 417.90 11.95 104 989217 46321 62453380
Hand deformity 411.66 11.95 4044 985277 155413 62344288
Rheumatoid nodule 408.90 11.95 857 988464 16298 62483403
Cardiac failure congestive 406.51 11.95 505 988816 91928 62407773
Syncope 405.76 11.95 756 988565 116629 62383072
Pneumocystis jirovecii pneumonia 400.87 11.95 843 988478 16071 62483630
Oedema peripheral 395.97 11.95 1564 987757 187947 62311754
Diffuse large B-cell lymphoma 391.65 11.95 503 988818 6209 62493492
Lactic acidosis 387.66 11.95 65 989256 38222 62461479
Exposure during pregnancy 380.95 11.95 1200 988121 154347 62345354
Tuberculosis 377.55 11.95 649 988672 10562 62489139
Tachycardia 372.39 11.95 803 988518 117353 62382348
Pemphigus 371.19 11.95 4437 984884 179289 62320412
Hospitalisation 351.41 11.95 487 988834 84594 62415107
Injection site reaction 351.38 11.95 1822 987499 56702 62442999
Coma 350.90 11.95 292 989029 64072 62435629
Injection site pain 347.78 11.95 3318 986003 126482 62373219
Hyperhidrosis 344.71 11.95 727 988594 107109 62392592
Orthostatic hypotension 343.45 11.95 72 989249 36088 62463613
Cognitive disorder 343.44 11.95 223 989098 55592 62444109
Metabolic acidosis 336.67 11.95 140 989181 44929 62454772
Foot deformity 335.14 11.95 1076 988245 26777 62472924
Blood glucose increased 331.53 11.95 494 988827 83262 62416439
Muscle spasms 331.03 11.95 1281 988040 154869 62344832
Fluid retention 330.07 11.95 267 989054 59419 62440282
Platelet count decreased 328.43 11.95 836 988485 115286 62384415
Product use issue 324.54 11.95 5031 984290 215489 62284212
Serotonin syndrome 317.84 11.95 37 989284 28645 62471056
Haemoglobin decreased 317.14 11.95 1180 988141 144305 62355396
Drug withdrawal syndrome 317.06 11.95 29 989292 27165 62472536
Pain in extremity 314.47 11.95 7064 982257 324422 62175279
Intentional self-injury 311.64 11.95 23 989298 25664 62474037
Respiratory arrest 310.06 11.95 65 989256 32580 62467121
Epstein Barr virus positive mucocutaneous ulcer 308.25 11.95 147 989174 300 62499401
Chest pain 308.01 11.95 2034 987287 213925 62285776
Chest discomfort 303.87 11.95 801 988520 109168 62390533
Interstitial lung disease 300.37 11.95 1820 987501 60088 62439613
Sopor 296.51 11.95 11 989310 22153 62477548
Lower respiratory tract infection 294.32 11.95 3256 986065 129051 62370650
Nodule 291.93 11.95 854 988467 20172 62479529
Nasopharyngitis 289.01 11.95 5565 983756 248692 62251009
Neuropathy peripheral 286.70 11.95 865 988456 112802 62386899
Therapeutic response decreased 283.58 11.95 1785 987536 59740 62439961
Unresponsive to stimuli 283.34 11.95 87 989234 33729 62465972
Stomatitis 279.94 11.95 3350 985971 135375 62364326
Acute graft versus host disease 279.30 11.95 345 988976 4083 62495618
Rheumatoid factor positive 278.58 11.95 2259 987062 82147 62417554
Hypoxia 278.57 11.95 312 989009 59480 62440221
Gastrointestinal haemorrhage 278.54 11.95 525 988796 80651 62419050
Bone erosion 277.74 11.95 752 988569 16965 62482736
Epstein-Barr virus associated lymphoproliferative disorder 275.89 11.95 232 989089 1662 62498039
Vision blurred 274.70 11.95 643 988678 91281 62408420
Confusional state 273.23 11.95 2361 986960 234019 62265682
Drug reaction with eosinophilia and systemic symptoms 269.54 11.95 95 989226 33741 62465960
Mobility decreased 260.53 11.95 2962 986359 118197 62381504
Glossodynia 259.65 11.95 4072 985249 174804 62324897
Herpes zoster 259.29 11.95 2183 987138 80279 62419422
Musculoskeletal pain 252.64 11.95 2370 986951 89907 62409794
Product quality issue 251.29 11.95 122 989199 35743 62463958
Vomiting 245.59 11.95 6742 982579 552875 61946826
Finger deformity 243.47 11.95 435 988886 7310 62492391
Musculoskeletal disorder 242.48 11.95 791 988530 19853 62479848
Ankylosing spondylitis 241.22 11.95 516 988805 9958 62489743
Flushing 240.95 11.95 505 988816 74582 62425119
Basal cell carcinoma 240.80 11.95 969 988352 27022 62472679
White blood cell count decreased 239.98 11.95 1232 988089 137872 62361829
Premature delivery 239.53 11.95 86 989235 30195 62469506
Suicidal ideation 237.59 11.95 378 988943 62043 62437658
Blood potassium decreased 237.40 11.95 184 989137 41842 62457859
Renal failure 236.14 11.95 986 988335 116666 62383035
Leukoencephalopathy 234.71 11.95 316 989005 4097 62495604
Disease progression 232.85 11.95 1051 988270 121707 62377994
Foetal exposure during pregnancy 232.80 11.95 103 989218 31859 62467842
Myalgia 232.27 11.95 1335 987986 145194 62354507
Cardiac failure 227.91 11.95 674 988647 88468 62411233
Palpitations 227.62 11.95 943 988378 111827 62387874
Mucosal inflammation 227.24 11.95 1379 987942 45549 62454152
Full blood count decreased 227.14 11.95 62 989259 25962 62473739
Dysgeusia 226.18 11.95 236 989085 46474 62453227
Blood calcium decreased 225.34 11.95 66 989255 26385 62473316
Joint range of motion decreased 224.13 11.95 1051 988270 31377 62468324
Asthma 223.89 11.95 1123 988198 126438 62373263
Impaired healing 223.65 11.95 2514 986807 100028 62399673
Knee arthroplasty 222.66 11.95 1528 987793 52678 62447023
Dyspnoea exertional 222.19 11.95 373 988948 59929 62439772
Epstein-Barr virus infection 221.54 11.95 427 988894 7623 62492078
Plasma cell myeloma 220.14 11.95 144 989177 35761 62463940
Uveitis 219.46 11.95 555 988766 11998 62487703
Pulmonary tuberculosis 218.53 11.95 309 989012 4208 62495493
Hypomagnesaemia 218.32 11.95 87 989234 28650 62471051
Restlessness 215.97 11.95 94 989227 29359 62470342
Mental status changes 215.39 11.95 180 989141 39419 62460282
Pulmonary embolism 213.60 11.95 1012 988309 115672 62384029
Cerebrovascular accident 212.66 11.95 912 988409 107112 62392589
Pulmonary fibrosis 210.32 11.95 1197 988124 38612 62461089
Grip strength decreased 209.97 11.95 794 988527 21493 62478208
Gastrooesophageal reflux disease 204.26 11.95 782 988539 94857 62404844
Wheezing 203.93 11.95 782 988539 94813 62404888
Dyskinesia 203.57 11.95 123 989198 31879 62467822
Lymphoma 202.91 11.95 529 988792 11658 62488043
Loss of consciousness 201.56 11.95 1050 988271 117071 62382630
Disturbance in attention 199.94 11.95 180 989141 38009 62461692
Hypersensitivity 199.50 11.95 5971 983350 286714 62212987
Neutrophil count decreased 197.74 11.95 360 988961 56046 62443655
Tuberculin test positive 195.32 11.95 257 989064 3254 62496447
Lethargy 193.19 11.95 361 988960 55646 62444055
Withdrawal syndrome 191.59 11.95 39 989282 19958 62479743
Disorientation 190.27 11.95 200 989121 39252 62460449
Hypervolaemia 189.60 11.95 103 989218 28310 62471391
Atrial fibrillation 188.95 11.95 1055 988266 115581 62384120
Creatinine renal clearance decreased 185.87 11.95 19 989302 16289 62483412
Chronic graft versus host disease 184.98 11.95 235 989086 2867 62496834
Blood pressure decreased 184.65 11.95 467 988854 64555 62435146
Palmar-plantar erythrodysaesthesia syndrome 182.66 11.95 65 989256 22950 62476751
Angiocentric lymphoma 182.59 11.95 117 989204 514 62499187
Pneumonia aspiration 180.59 11.95 163 989158 34377 62465324
Pulmonary hypertension 180.37 11.95 187 989134 36936 62462765
Fear of injection 180.26 11.95 366 988955 6798 62492903
Anti-cyclic citrullinated peptide antibody positive 179.87 11.95 2675 986646 113537 62386164
Hyperglycaemia 179.58 11.95 233 989088 41634 62458067
Tenosynovitis 178.91 11.95 547 988774 13248 62486453
Angioedema 178.27 11.95 295 989026 47670 62452031
Abdominal pain 177.43 11.95 3362 985959 290094 62209607
Skin ulcer 177.14 11.95 1214 988107 41831 62457870
Blood iron abnormal 172.70 11.95 255 989066 3621 62496080
Hallucination, visual 172.18 11.95 44 989277 19254 62480447
Arthritis bacterial 171.99 11.95 338 988983 6125 62493576
Device dislocation 171.80 11.95 93 989228 25612 62474089
Wound 171.09 11.95 3531 985790 159732 62339969
Abnormal behaviour 170.93 11.95 60 989261 21366 62478335
Juvenile idiopathic arthritis 170.58 11.95 234 989087 3092 62496609
Injection site bruising 169.51 11.95 1177 988144 40733 62458968
Pulmonary oedema 169.44 11.95 377 988944 54496 62445205
Injection site erythema 169.20 11.95 2012 987309 81162 62418539
Joint effusion 167.56 11.95 616 988705 16444 62483257
Deformity 167.43 11.95 480 988841 11204 62488497
Blood alkaline phosphatase increased 166.54 11.95 257 989064 42710 62456991
Paraesthesia 166.37 11.95 1602 987719 155364 62344337
Aggression 164.52 11.95 80 989241 23418 62476283
Caesarean section 163.63 11.95 33 989288 16999 62482702
Depression 162.98 11.95 2120 987201 194372 62305329
Ventricular tachycardia 161.02 11.95 55 989266 19924 62479777
Sinusitis 160.90 11.95 4648 984673 222005 62277696
Breast cancer 160.71 11.95 1297 988024 47086 62452615
Histoplasmosis disseminated 159.81 11.95 152 989169 1304 62498397
Poisoning deliberate 159.63 11.95 3 989318 11215 62488486
Intentional product misuse 158.31 11.95 457 988864 60460 62439241
B-cell lymphoma 158.28 11.95 225 989096 3080 62496621
Neuroleptic malignant syndrome 157.85 11.95 7 989314 12049 62487652
Psychotic disorder 156.44 11.95 104 989217 25608 62474093
Pulmonary arterial hypertension 156.35 11.95 78 989243 22499 62477202
Respiratory depression 156.26 11.95 16 989305 13699 62486002
Muscle twitching 155.32 11.95 56 989265 19612 62480089
Blood creatinine increased 154.29 11.95 773 988548 87071 62412630
Torsade de pointes 153.62 11.95 15 989306 13336 62486365
Diabetic ketoacidosis 152.65 11.95 64 989257 20441 62479260
Joint destruction 152.11 11.95 315 989006 5937 62493764
Dactylitis 151.23 11.95 195 989126 2417 62497284
Premature baby 149.16 11.95 68 989253 20667 62479034
Dysphagia 149.11 11.95 791 988530 87794 62411907
Sinus bradycardia 148.86 11.95 24 989297 14527 62485174
Injection site pruritus 146.92 11.95 1204 988117 43912 62455789
Urinary retention 146.80 11.95 153 989168 30148 62469553
Epistaxis 146.18 11.95 609 988712 72116 62427585
Dry skin 144.75 11.95 431 988890 56456 62443245
Memory impairment 143.95 11.95 991 988330 103267 62396434
Ill-defined disorder 143.81 11.95 1925 987396 79830 62419871
Blood urea increased 142.12 11.95 121 989200 26258 62473443
Pulmonary toxicity 141.91 11.95 395 988926 9060 62490641
Neoplasm progression 140.12 11.95 219 989102 36209 62463492
Acute graft versus host disease in skin 139.47 11.95 217 989104 3235 62496466
Right ventricular failure 139.07 11.95 47 989274 17141 62482560
Blood sodium decreased 138.47 11.95 105 989216 24147 62475554
Emotional distress 137.70 11.95 183 989138 32366 62467335
Lung disorder 137.31 11.95 1530 987791 60731 62438970
Disseminated tuberculosis 137.04 11.95 195 989126 2672 62497029
Obstructive airways disorder 136.72 11.95 76 989245 20623 62479078
Melaena 136.51 11.95 163 989158 30202 62469499
Irritability 136.33 11.95 176 989145 31518 62468183
Myoclonus 136.26 11.95 39 989282 15829 62483872
Febrile bone marrow aplasia 135.57 11.95 331 988990 6994 62492707
Infusion site pain 134.98 11.95 47 989274 16822 62482879
Dystonia 134.39 11.95 26 989295 13793 62485908
Rash 134.21 11.95 10308 979013 550563 61949138
Extrapyramidal disorder 133.48 11.95 23 989298 13261 62486440
Osteoporosis 133.36 11.95 1424 987897 55914 62443787
Bone pain 133.33 11.95 422 988899 54219 62445482
Malignant melanoma 132.35 11.95 434 988887 10922 62488779
Lymphocyte count decreased 132.24 11.95 166 989155 30091 62469610
Deep vein thrombosis 131.91 11.95 765 988556 83035 62416666
Insomnia 131.56 11.95 2461 986860 212791 62286910
Contraindication to medical treatment 131.12 11.95 98 989223 578 62499123
Acute respiratory failure 129.17 11.95 211 989110 34274 62465427
Urinary tract infection 128.91 11.95 3139 986182 261545 62238156
Full blood count abnormal 127.49 11.95 185 989136 31532 62468169
Drug clearance decreased 126.32 11.95 135 989186 1349 62498352
Blood bilirubin increased 125.79 11.95 242 989079 36898 62462803
Delirium 125.67 11.95 387 988934 50154 62449547
Pustular psoriasis 125.62 11.95 244 989077 4382 62495319
Thrombocytopenia 124.88 11.95 1632 987689 149525 62350176
Abortion spontaneous 124.88 11.95 351 988970 46844 62452857
Parkinsonism 124.79 11.95 10 989311 10429 62489272
Heart rate increased 124.61 11.95 907 988414 93331 62406370
Polyarthritis 122.08 11.95 392 988929 9754 62489947
Anhedonia 121.98 11.95 14 989307 10960 62488741
Folliculitis 121.33 11.95 1650 987671 68667 62431034
Haemophagocytic lymphohistiocytosis 121.05 11.95 403 988918 10224 62489477
Mania 120.83 11.95 23 989298 12344 62487357
Off label use 120.26 11.95 12130 977191 662332 61837369
Electrolyte imbalance 119.74 11.95 83 989238 19993 62479708
Fine motor skill dysfunction 117.26 11.95 243 989078 4582 62495119
Pulmonary mass 117.09 11.95 676 988645 21920 62477781
Neutropenia 117.04 11.95 1969 987352 173036 62326665
Pericarditis 116.97 11.95 2780 986541 128799 62370902
Immunosuppression 116.65 11.95 352 988969 8462 62491239
Sinus tachycardia 115.93 11.95 124 989197 24144 62475557
Arthrodesis 115.86 11.95 178 989143 2623 62497078
Transfusion 115.70 11.95 46 989275 15171 62484530
Infusion related reaction 115.37 11.95 4801 984520 240720 62258981
Poisoning 115.21 11.95 35 989286 13665 62486036
Nightmare 114.94 11.95 79 989242 19115 62480586
Akathisia 114.43 11.95 7 989314 9139 62490562
Abdominal distension 114.34 11.95 834 988487 85781 62413920
Presyncope 113.72 11.95 160 989161 27625 62472076
Circulatory collapse 112.94 11.95 105 989216 21833 62477868
Adverse reaction 112.75 11.95 383 988938 9820 62489881
Macular degeneration 112.64 11.95 128 989193 24248 62475453
Hypocalcaemia 112.40 11.95 201 989120 31512 62468189
Upper gastrointestinal haemorrhage 112.35 11.95 78 989243 18774 62480927
Hepatotoxicity 111.86 11.95 972 988349 36069 62463632
Chills 111.85 11.95 1177 988144 112201 62387500
Muscle injury 111.38 11.95 1530 987791 63815 62435886
Oedema 111.32 11.95 978 988343 96644 62403057
Disability 111.32 11.95 573 988748 17774 62481927
Myocardial infarction 111.17 11.95 1007 988314 98886 62400815
Fibromyalgia 111.00 11.95 1816 987505 78604 62421097
Premature labour 110.62 11.95 29 989292 12475 62487226
Arrhythmia 110.56 11.95 271 989050 37869 62461832
Schizophrenia 109.86 11.95 13 989308 9939 62489762
Deafness transitory 109.28 11.95 144 989177 1826 62497875
Hallucination, auditory 109.23 11.95 32 989289 12792 62486909
Paraesthesia oral 109.14 11.95 84 989237 19172 62480529
Speech disorder 109.10 11.95 300 989021 40329 62459372
Blood creatine phosphokinase increased 108.63 11.95 192 989129 30238 62469463
Diverticulitis 108.21 11.95 1016 988305 38541 62461160
Acute myocardial infarction 108.20 11.95 210 989111 31914 62467787
Wrong technique in product usage process 107.51 11.95 552 988769 61788 62437913
Cardiac disorder 107.50 11.95 417 988904 50399 62449302
Thrombosis 107.42 11.95 581 988740 64174 62435527
Pallor 107.21 11.95 195 989126 30373 62469328
Dysarthria 106.94 11.95 326 988995 42385 62457316
Mycobacterium tuberculosis complex test positive 105.97 11.95 152 989169 2099 62497602
Hospice care 105.89 11.95 4 989317 7928 62491773
Rash maculo-papular 105.28 11.95 211 989110 31685 62468016
Muscle rigidity 104.97 11.95 25 989296 11475 62488226
Demyelination 104.75 11.95 290 989031 6630 62493071
Chronic kidney disease 103.62 11.95 361 988960 45037 62454664
Altered state of consciousness 103.55 11.95 145 989176 25085 62474616
Blood glucose decreased 103.54 11.95 104 989217 20848 62478853
Cardiogenic shock 103.20 11.95 77 989244 17855 62481846
Rheumatoid lung 102.10 11.95 201 989120 3647 62496054
Impaired work ability 102.05 11.95 540 988781 16935 62482766
Synovial cyst 101.86 11.95 376 988945 10057 62489644
Panniculitis 101.83 11.95 399 988922 10986 62488715
Cholecystitis chronic 101.81 11.95 19 989302 10342 62489359
Feeling abnormal 100.70 11.95 1665 987656 146727 62352974
Head injury 99.49 11.95 171 989150 27225 62472476
Neuroendocrine carcinoma of the skin 98.95 11.95 79 989242 521 62499180
Tubulointerstitial nephritis 98.11 11.95 99 989222 19804 62479897
Shoulder arthroplasty 97.79 11.95 202 989119 3800 62495901
Injection site swelling 97.69 11.95 1153 988168 46419 62453282
Lupus-like syndrome 97.24 11.95 484 988837 14811 62484890
Oral herpes 97.16 11.95 718 988603 25356 62474345
Complication of device insertion 97.07 11.95 5 989316 7559 62492142
Discomfort 96.26 11.95 3347 985974 164027 62335674
Lip swelling 96.23 11.95 213 989108 30850 62468851
Infusion site erythema 96.13 11.95 31 989290 11648 62488053
Foot operation 95.90 11.95 289 989032 6942 62492759
Swollen tongue 95.67 11.95 254 989067 34546 62465155
Blood magnesium decreased 95.38 11.95 43 989278 13155 62486546
Hip arthroplasty 95.29 11.95 1149 988172 46497 62453204
Chronic obstructive pulmonary disease 94.56 11.95 580 988741 62106 62437595
Cerebral haemorrhage 94.14 11.95 212 989109 30517 62469184
Tardive dyskinesia 94.12 11.95 11 989310 8491 62491210
Enthesopathy 94.00 11.95 322 988999 8292 62491409
Complication associated with device 93.78 11.95 76 989245 16902 62482799
Latent tuberculosis 93.65 11.95 156 989165 2471 62497230
Bone marrow failure 93.40 11.95 778 988543 28512 62471189
Rectal haemorrhage 93.37 11.95 419 988902 48611 62451090
Mucosal ulceration 93.16 11.95 94 989227 873 62498828
Irritable bowel syndrome 93.13 11.95 1803 987518 80609 62419092
Product substitution issue 92.94 11.95 68 989253 15928 62483773
Joint injury 91.38 11.95 780 988541 28792 62470909
Hypophosphataemia 91.14 11.95 32 989289 11394 62488307
Venoocclusive liver disease 91.10 11.95 220 989101 4615 62495086
Hypothermia 90.95 11.95 49 989272 13532 62486169
Haemorrhage 90.80 11.95 567 988754 60455 62439246
Jaundice 90.27 11.95 201 989120 29050 62470651
Sensitivity to weather change 90.17 11.95 283 989038 6954 62492747
Flatulence 89.67 11.95 261 989060 34441 62465260
Infusion site swelling 89.65 11.95 21 989300 9749 62489952
Paranoia 89.30 11.95 35 989286 11644 62488057
Urinary incontinence 89.28 11.95 232 989089 31782 62467919
Injection site warmth 89.04 11.95 470 988851 14725 62484976
Status epilepticus 88.19 11.95 65 989256 15168 62484533
Pregnancy 88.11 11.95 287 989034 36549 62463152
Stevens-Johnson syndrome 87.65 11.95 159 989162 24791 62474910
Elbow deformity 87.55 11.95 113 989208 1402 62498299
Depressed mood 87.48 11.95 326 988995 39865 62459836
Pleural effusion 87.37 11.95 979 988342 92231 62407470
Swelling face 87.27 11.95 604 988717 62871 62436830
Eosinophilia 86.39 11.95 138 989183 22618 62477083
Joint arthroplasty 86.22 11.95 154 989167 2587 62497114
No adverse event 86.16 11.95 342 988979 41063 62458638
Spinal stenosis 85.65 11.95 459 988862 14466 62485235
Cytokine release syndrome 85.60 11.95 59 989262 14255 62485446
Delusion 85.52 11.95 40 989281 11977 62487724
Ejection fraction decreased 85.18 11.95 135 989186 22197 62477504
Hypomania 85.16 11.95 3 989318 6327 62493374
Hypothyroidism 85.04 11.95 358 988963 42274 62457427
Sleep apnoea syndrome 84.44 11.95 207 989114 28926 62470775
Respiratory distress 84.38 11.95 260 989061 33691 62466010
Haematoma 84.18 11.95 270 989051 34550 62465151
Coronary artery disease 84.03 11.95 243 989078 32134 62467567
Respiratory failure 84.00 11.95 1100 988221 100758 62398943
Oxygen saturation decreased 83.59 11.95 929 988392 87656 62412045
Pharyngitis 83.39 11.95 569 988752 19574 62480127
Graft versus host disease 82.92 11.95 263 989058 6500 62493201
Mental disorder 82.55 11.95 175 989146 25744 62473957
Foetal methotrexate syndrome 82.23 11.95 40 989281 87 62499614
Immobile 82.12 11.95 241 989080 5702 62493999
Device difficult to use 81.64 11.95 49 989272 12747 62486954
Dysuria 80.60 11.95 263 989058 33475 62466226
Hodgkin's disease 80.44 11.95 80 989241 729 62498972
Leukocytosis 80.21 11.95 178 989143 25757 62473944
Mycobacterium marinum infection 80.11 11.95 51 989270 221 62499480
Ascites 80.01 11.95 344 988977 40384 62459317
Acute hepatic failure 79.62 11.95 101 989220 18226 62481475
Abnormal dreams 79.61 11.95 32 989289 10484 62489217
Ulcer 79.30 11.95 686 988635 25421 62474280
Electrocardiogram QRS complex prolonged 79.25 11.95 3 989318 5935 62493766
Haematemesis 79.11 11.95 228 989093 30184 62469517
Aphthous ulcer 78.87 11.95 427 988894 13511 62486190
Mydriasis 78.82 11.95 44 989277 11912 62487789
Treatment noncompliance 78.49 11.95 307 989014 37018 62462683
Hypofibrinogenaemia 78.41 11.95 94 989227 1076 62498625
Generalised tonic-clonic seizure 78.10 11.95 214 989107 28802 62470899
Acute generalised exanthematous pustulosis 77.37 11.95 38 989283 11061 62488640
Atrioventricular block 77.36 11.95 13 989308 7634 62492067
Pollakiuria 76.73 11.95 204 989117 27733 62471968
Myelopathy 76.66 11.95 149 989172 2677 62497024
Product administration error 76.66 11.95 145 989176 22252 62477449
Red blood cell count decreased 76.41 11.95 349 988972 40296 62459405
Limb deformity 76.38 11.95 183 989138 3819 62495882
Dementia 76.15 11.95 109 989212 18685 62481016
Haematocrit decreased 75.63 11.95 335 988986 39005 62460696
Hepatic steatosis 74.77 11.95 731 988590 28038 62471663
Uterine perforation 74.66 11.95 10 989311 6953 62492748
Atrial septal defect 74.31 11.95 10 989311 6928 62492773
Histoplasmosis 74.25 11.95 120 989201 1851 62497850
Hepatic fibrosis 74.06 11.95 171 989150 3481 62496220
Cyanosis 73.91 11.95 93 989228 16842 62482859
Hepatic encephalopathy 73.68 11.95 42 989279 11240 62488461
Transient ischaemic attack 72.87 11.95 321 989000 37432 62462269
Procedural pain 72.64 11.95 141 989180 21428 62478273
Sleep disorder due to general medical condition, insomnia type 72.36 11.95 1180 988141 51037 62448664
Mucocutaneous ulceration 72.20 11.95 41 989280 137 62499564
Transplant rejection 72.04 11.95 39 989282 10741 62488960
Liver disorder 71.37 11.95 1205 988116 52482 62447219
Wrist deformity 71.31 11.95 123 989198 2007 62497694
Rhinitis allergic 70.58 11.95 48 989273 11679 62488022
Lymph node tuberculosis 70.34 11.95 74 989247 725 62498976
Somnambulism 70.09 11.95 4 989317 5539 62494162
Atrioventricular block first degree 70.06 11.95 14 989307 7259 62492442
Visceral leishmaniasis 69.98 11.95 63 989258 500 62499201
Moebius II syndrome 69.45 11.95 23 989298 4 62499697
Inflammatory marker increased 68.90 11.95 249 989072 6590 62493111
Retinal toxicity 68.88 11.95 92 989229 1183 62498518
Infusion site pruritus 68.86 11.95 7 989314 6028 62493673
Ventricular extrasystoles 68.80 11.95 49 989272 11638 62488063
Foetal death 68.72 11.95 43 989278 10937 62488764
Chromaturia 68.68 11.95 96 989225 16621 62483080
Metastases to bone 68.56 11.95 140 989181 20879 62478822
Gamma-glutamyltransferase increased 68.35 11.95 285 989036 33746 62465955
Anuria 68.31 11.95 57 989264 12494 62487207
Joint dislocation 67.96 11.95 514 988807 18286 62481415
Dialysis 67.83 11.95 39 989282 10388 62489313
Exposure to toxic agent 67.78 11.95 5 989316 5582 62494119
Fear 67.34 11.95 88 989233 15678 62484023
Incorrect product administration duration 67.19 11.95 49 989272 11497 62488204
Tachypnoea 65.61 11.95 105 989216 17197 62482504
Pulseless electrical activity 65.48 11.95 18 989303 7503 62492198
Atypical mycobacterial infection 65.07 11.95 83 989238 1017 62498684
Hot flush 64.93 11.95 498 988823 50661 62449040
Vascular device infection 64.60 11.95 17 989304 7295 62492406
Troponin increased 64.23 11.95 39 989282 10082 62489619
Acute graft versus host disease in intestine 63.88 11.95 105 989216 1644 62498057
Hypovolaemia 63.81 11.95 44 989277 10629 62489072
Toxic epidermal necrolysis 63.68 11.95 193 989128 25141 62474560
Tinnitus 63.41 11.95 312 989009 35316 62464385
Epicondylitis 63.38 11.95 119 989202 2081 62497620
Graft versus host disease in skin 63.34 11.95 140 989181 2765 62496936
Epidermal necrosis 63.33 11.95 80 989241 970 62498731
Inappropriate antidiuretic hormone secretion 63.31 11.95 89 989232 15373 62484328
Granuloma skin 63.16 11.95 280 989041 8157 62491544
Hypoaesthesia oral 62.91 11.95 66 989255 12967 62486734
Acidosis 62.40 11.95 50 989271 11183 62488518
Psychomotor hyperactivity 62.38 11.95 45 989276 10618 62489083
Ventricular fibrillation 62.03 11.95 56 989265 11811 62487890
Hepatitis 61.95 11.95 917 988404 38871 62460830
Product physical issue 61.74 11.95 4 989317 4976 62494725
Blood potassium increased 61.39 11.95 120 989201 18189 62481512
Retching 61.27 11.95 83 989238 14562 62485139
Mood altered 61.23 11.95 84 989237 14659 62485042
Diabetes mellitus inadequate control 61.01 11.95 88 989233 15038 62484663
Stillbirth 60.97 11.95 15 989306 6735 62492966
Device breakage 60.89 11.95 54 989267 11488 62488213
Adverse drug reaction 60.72 11.95 1650 987671 78064 62421637
Taste disorder 60.70 11.95 74 989247 13588 62486113
Ageusia 60.32 11.95 75 989246 13653 62486048
SLE arthritis 59.83 11.95 63 989258 618 62499083
Localised infection 59.74 11.95 727 988594 29483 62470218
Gestational diabetes 59.67 11.95 28 989293 8368 62491333
Pre-eclampsia 59.64 11.95 34 989287 9099 62490602
Blood loss anaemia 59.51 11.95 33 989288 8968 62490733
Nasal polyps 59.50 11.95 11 989310 6028 62493673
Normal newborn 59.00 11.95 28 989293 8313 62491388
Hereditary angioedema 58.92 11.95 22 989299 7540 62492161
Dermatitis allergic 58.66 11.95 421 988900 14727 62484974
Salivary hypersecretion 58.57 11.95 23 989298 7643 62492058
Insurance issue 58.51 11.95 12 989309 6109 62493592
Haemorrhage intracranial 58.24 11.95 74 989247 13345 62486356
Rheumatoid factor negative 58.14 11.95 59 989262 552 62499149
Neck pain 58.08 11.95 1453 987868 67865 62431836
Therapy non-responder 58.08 11.95 1572 987749 74329 62425372
Feeling hot 58.03 11.95 503 988818 49851 62449850
Body height below normal 57.89 11.95 114 989207 2069 62497632
Ankle deformity 57.88 11.95 53 989268 431 62499270
Lennox-Gastaut syndrome 57.88 11.95 42 989279 235 62499466
Investigation abnormal 57.77 11.95 107 989214 1851 62497850
Bronchitis chronic 57.75 11.95 174 989147 4179 62495522
Hyperthyroidism 57.59 11.95 87 989234 14586 62485115
Hyperlipidaemia 57.55 11.95 138 989183 19433 62480268
Helicobacter infection 57.51 11.95 1872 987449 90913 62408788
Product complaint 57.31 11.95 69 989252 12740 62486961
Musculoskeletal deformity 57.18 11.95 105 989216 1804 62497897
Renal injury 56.32 11.95 39 989282 9400 62490301
Haematotoxicity 56.31 11.95 292 989029 9084 62490617
Haemoptysis 56.20 11.95 243 989078 28483 62471218
Tricuspid valve incompetence 56.13 11.95 88 989233 14533 62485168
Genital haemorrhage 56.01 11.95 22 989299 7310 62492391
Nervousness 55.87 11.95 270 989051 30709 62468992
Anger 55.84 11.95 67 989254 12389 62487312
Device use error 55.68 11.95 11 989310 5750 62493951
Injection site haemorrhage 55.66 11.95 602 988719 23712 62475989
Drug tolerance decreased 55.64 11.95 464 988857 17009 62482692
Scleritis 55.03 11.95 173 989148 4255 62495446
Pneumonia cryptococcal 55.01 11.95 65 989256 732 62498969
Respiratory acidosis 54.96 11.95 18 989303 6697 62493004
Transaminases increased 54.89 11.95 738 988583 30629 62469072
Acute lymphocytic leukaemia recurrent 54.82 11.95 114 989207 2155 62497546
Pregnancy with contraceptive device 54.73 11.95 5 989316 4689 62495012
Supraventricular tachycardia 54.69 11.95 86 989235 14185 62485516
Nausea 54.60 11.95 12135 977186 842336 61657365
Unevaluable event 54.57 11.95 524 988797 50862 62448839
Jaundice cholestatic 54.29 11.95 23 989298 7301 62492400
Systemic infection 54.24 11.95 5 989316 4655 62495046
Panic attack 54.09 11.95 173 989148 22158 62477543
Hyperreflexia 53.97 11.95 13 989308 5921 62493780
Extranodal marginal zone B-cell lymphoma (MALT type) 53.71 11.95 52 989269 457 62499244
Hypersensitivity pneumonitis 53.64 11.95 124 989197 2526 62497175
Epilepsy 53.53 11.95 228 989093 26837 62472864
Gastrointestinal pain 52.97 11.95 296 989025 9480 62490221
Sickle cell anaemia with crisis 52.95 11.95 14 989307 5989 62493712
Chronic graft versus host disease in skin 52.95 11.95 62 989259 691 62499010
Epstein-Barr virus associated lymphoma 52.94 11.95 52 989269 466 62499235
Infusion site haemorrhage 52.91 11.95 8 989313 5078 62494623
Headache 52.83 11.95 8869 980452 624372 61875329
Hip fracture 52.51 11.95 258 989063 29216 62470485
Blister 52.43 11.95 2500 986821 127314 62372387
Amnesia 52.40 11.95 583 988738 55002 62444699
Liver function test abnormal 52.36 11.95 1048 988273 47133 62452568
Muscle tightness 52.30 11.95 65 989256 11835 62487866
Face oedema 52.23 11.95 152 989169 20060 62479641
Neurotoxicity 51.90 11.95 447 988874 16543 62483158
Lip ulceration 51.89 11.95 105 989216 1945 62497756
Bradyphrenia 51.61 11.95 22 989299 6958 62492743
Chronic sinusitis 51.53 11.95 75 989246 12768 62486933
Bronchospasm 51.49 11.95 121 989200 17159 62482542
Pneumonitis 51.45 11.95 803 988518 34419 62465282
Hepatic cirrhosis 51.45 11.95 601 988720 24133 62475568
Cholelithiasis 51.41 11.95 437 988884 43488 62456213
Eye swelling 51.40 11.95 195 989126 23723 62475978
Thinking abnormal 51.26 11.95 54 989267 10589 62489112
Pancreatitis acute 51.21 11.95 233 989088 26933 62472768
Hypercapnia 51.19 11.95 11 989310 5420 62494281
Lung adenocarcinoma 51.18 11.95 173 989148 4424 62495277
Cataract 51.14 11.95 1207 988114 55846 62443855
Glycosylated haemoglobin increased 51.13 11.95 71 989250 12327 62487374
Temporal lobe epilepsy 51.10 11.95 46 989275 365 62499336
Cholestasis 51.10 11.95 260 989061 29174 62470527
Injury 50.93 11.95 818 988503 72429 62427272
Blood pressure fluctuation 50.85 11.95 1009 988312 45308 62454393
Heparin-induced thrombocytopenia 50.54 11.95 6 989315 4576 62495125
Non-Hodgkin's lymphoma 50.54 11.95 84 989237 1328 62498373
Product preparation error 50.44 11.95 16 989305 6076 62493625
Ovarian hyperstimulation syndrome 50.44 11.95 3 989318 4011 62495690
Hepatitis B reactivation 50.02 11.95 134 989187 3003 62496698
Vertigo 50.00 11.95 645 988676 59242 62440459
Personality change 49.95 11.95 23 989298 6950 62492751
Bradykinesia 49.95 11.95 10 989311 5178 62494523
Migraine 49.84 11.95 1227 988094 102119 62397582
Unintended pregnancy 49.81 11.95 17 989304 6162 62493539
Sacroiliitis 49.80 11.95 137 989184 3120 62496581
Non-alcoholic steatohepatitis 49.77 11.95 92 989229 1589 62498112
Amyotrophic lateral sclerosis 49.65 11.95 75 989246 1088 62498613
Skin necrosis 49.64 11.95 380 988941 13570 62486131
Synovectomy 49.53 11.95 33 989288 157 62499544
Blood parathyroid hormone decreased 49.48 11.95 291 989030 9500 62490201
Graft versus host disease in gastrointestinal tract 49.23 11.95 136 989185 3105 62496596
Catatonia 49.05 11.95 6 989315 4471 62495230
Adult T-cell lymphoma/leukaemia 49.04 11.95 35 989286 190 62499511
Throat tightness 49.01 11.95 210 989111 24677 62475024
Skin cancer 48.95 11.95 327 988994 11168 62488533
Tonsillitis 48.89 11.95 198 989123 5537 62494164
Muscular weakness 48.84 11.95 1492 987829 120861 62378840
Dermatitis atopic 48.35 11.95 48 989273 9676 62490025
Labelled drug-drug interaction medication error 48.32 11.95 84 989237 13315 62486386
Therapy interrupted 48.05 11.95 302 989019 32153 62467548
Spondyloarthropathy 47.91 11.95 64 989257 823 62498878
Blood calcium increased 47.83 11.95 45 989276 9305 62490396
Aspartate aminotransferase increased 47.39 11.95 1058 988263 89219 62410482
Posterior reversible encephalopathy syndrome 47.18 11.95 445 988876 16900 62482801
Spinal column injury 47.18 11.95 101 989220 1950 62497751
Ischaemic stroke 47.16 11.95 134 989187 17823 62481878
Duodenal ulcer perforation 47.15 11.95 1732 987589 85477 62414224
Osteoporotic fracture 47.14 11.95 147 989174 3599 62496102
Varicella zoster virus infection 47.12 11.95 119 989202 2570 62497131
Wrist surgery 47.06 11.95 63 989258 812 62498889
Forced expiratory volume decreased 46.95 11.95 10 989311 4958 62494743
Aspiration 46.93 11.95 60 989261 10791 62488910
Atrioventricular block complete 46.75 11.95 36 989285 8215 62491486
Clonus 46.64 11.95 8 989313 4628 62495073
Drug ineffective for unapproved indication 46.54 11.95 768 988553 33295 62466406
Eye pruritus 46.38 11.95 143 989178 18528 62481173
Hepatosplenic T-cell lymphoma 46.37 11.95 52 989269 551 62499150
Onychomycosis 46.24 11.95 245 989076 7687 62492014
Seasonal allergy 46.20 11.95 169 989152 20781 62478920
Renal disorder 46.19 11.95 312 989009 32662 62467039
Atrioventricular block second degree 46.09 11.95 4 989317 3910 62495791
Electrocardiogram abnormal 46.00 11.95 45 989276 9134 62490567
Hypotonia 45.98 11.95 46 989275 9239 62490462
Neutrophil count increased 45.90 11.95 120 989201 16407 62483294
Hyperprolactinaemia 45.89 11.95 4 989317 3896 62495805
Patent ductus arteriosus 45.82 11.95 6 989315 4244 62495457
Faeces discoloured 45.81 11.95 142 989179 18367 62481334
Mesenteritis 45.78 11.95 39 989282 285 62499416
Adenovirus infection 45.75 11.95 141 989180 3430 62496271
Dry mouth 45.72 11.95 896 988425 76967 62422734
Prothrombin time prolonged 45.53 11.95 49 989272 9515 62490186
Mental impairment 45.52 11.95 95 989226 14056 62485645
Foetal growth restriction 45.34 11.95 31 989290 7522 62492179
Adactyly 45.31 11.95 20 989301 31 62499670
Erythema multiforme 45.27 11.95 55 989266 10114 62489587
Erythema 45.20 11.95 2257 987064 173494 62326207
Surgical failure 45.14 11.95 65 989256 901 62498800
Skin plaque 45.14 11.95 252 989069 8068 62491633
End stage renal disease 45.04 11.95 24 989297 6669 62493032
Rheumatoid factor increased 44.79 11.95 93 989228 1756 62497945
Renal impairment 44.53 11.95 1042 988279 87313 62412388
Breast cancer stage I 44.48 11.95 26 989295 6863 62492838
Intestinal obstruction 44.48 11.95 290 989031 30609 62469092
Shock 44.38 11.95 201 989120 23262 62476439
Palmoplantar pustulosis 44.25 11.95 47 989274 466 62499235
Pleurisy 44.18 11.95 251 989070 8089 62491612
Oligohydramnios 44.07 11.95 22 989299 6344 62493357
Lower gastrointestinal haemorrhage 43.98 11.95 35 989286 7855 62491846
Sleep disorder 43.87 11.95 1619 987702 79947 62419754
Accidental exposure to product 43.74 11.95 249 989072 27156 62472545
Granulomatous pneumonitis 43.68 11.95 21 989300 44 62499657
Tenderness 43.63 11.95 541 988780 22037 62477664
Underdose 43.53 11.95 250 989071 27206 62472495
Malignant respiratory tract neoplasm 43.51 11.95 20 989301 36 62499665
Joint noise 43.48 11.95 159 989162 4233 62495468
Glomerular filtration rate decreased 43.43 11.95 90 989231 13351 62486350
Dizziness postural 43.32 11.95 31 989290 7345 62492356
Renal tubular necrosis 43.25 11.95 74 989247 11804 62487897
Application site erythema 43.18 11.95 11 989310 4824 62494877
Drug specific antibody 43.14 11.95 106 989215 2249 62497452
Pneumonia legionella 43.12 11.95 86 989235 1576 62498125
Skin erosion 43.09 11.95 113 989208 2499 62497202
Pruritus 43.09 11.95 4952 984369 356501 62143200
Systemic lupus erythematosus rash 43 11.95 103 989218 2149 62497552
Pre-existing condition improved 42.98 11.95 39 989282 8205 62491496
Increased appetite 42.96 11.95 52 989269 9578 62490123
Blood prolactin increased 42.88 11.95 3 989318 3500 62496201
Acute coronary syndrome 42.76 11.95 57 989264 10069 62489632
Encephalopathy 42.65 11.95 390 988931 38230 62461471
Euglycaemic diabetic ketoacidosis 42.61 11.95 4 989317 3670 62496031
Mycobacterium chelonae infection 42.57 11.95 46 989275 466 62499235
Nasal ulcer 42.52 11.95 104 989217 2200 62497501
Hypernatraemia 42.10 11.95 34 989287 7575 62492126
Diffuse large B-cell lymphoma stage IV 42.06 11.95 36 989285 265 62499436
Metabolic encephalopathy 41.86 11.95 19 989302 5790 62493911
Low birth weight baby 41.82 11.95 30 989291 7099 62492602
Dermatitis psoriasiform 41.72 11.95 102 989219 2157 62497544
Left ventricular dysfunction 41.57 11.95 77 989244 11911 62487790
Pericardial effusion 41.32 11.95 286 989035 29772 62469929
Urine leukocyte esterase positive 41.23 11.95 4 989317 3575 62496126
Induced abortion failed 41.17 11.95 33 989288 219 62499482
Thyroid neoplasm 41.06 11.95 147 989174 3872 62495829
Oral mucosal exfoliation 41.02 11.95 84 989237 1570 62498131
Sleep disorder due to a general medical condition 40.76 11.95 80 989241 12108 62487593
Infusion site extravasation 40.74 11.95 62 989259 10364 62489337
Cutaneous leishmaniasis 40.69 11.95 23 989298 76 62499625
Vaginal discharge 40.68 11.95 50 989271 9148 62490553
Bone swelling 40.66 11.95 85 989236 1613 62498088
Food allergy 40.63 11.95 72 989249 11329 62488372
Thirst 40.51 11.95 100 989221 13941 62485760
Osteonecrosis of jaw 40.40 11.95 351 988970 34772 62464929
Urine output decreased 40.35 11.95 72 989249 11298 62488403
Blood pressure systolic abnormal 40.27 11.95 351 988970 13035 62486666
Peritoneal tuberculosis 40.26 11.95 44 989277 452 62499249
Hepatitis E 40.23 11.95 77 989244 1367 62498334
Eye disorder 40.22 11.95 535 988786 22150 62477551
Human antichimeric antibody positive 40.11 11.95 85 989236 1629 62498072
Peritonitis bacterial 40.07 11.95 13 989308 4866 62494835
Mitral valve incompetence 40.03 11.95 163 989158 19431 62480270
Disturbance in social behaviour 39.93 11.95 7 989314 3986 62495715
Disability assessment scale score increased 39.89 11.95 126 989195 3107 62496594
Subdural haematoma 39.82 11.95 104 989217 14224 62485477
Tendon rupture 39.80 11.95 242 989079 7997 62491704
Vaginal flatulence 39.80 11.95 3 989318 3290 62496411
Myocarditis 39.77 11.95 62 989259 10263 62489438
Cytomegalovirus chorioretinitis 39.76 11.95 87 989234 1706 62497995
Organising pneumonia 39.75 11.95 187 989134 5589 62494112
Hepatic enzyme abnormal 39.73 11.95 201 989120 6191 62493510
Catheter site erythema 39.62 11.95 9 989312 4267 62495434
Maternal drugs affecting foetus 39.60 11.95 16 989305 5226 62494475
Coagulopathy 39.45 11.95 175 989146 20369 62479332
Hypoaesthesia 39.43 11.95 2183 987138 166210 62333491
Leukopenia 39.38 11.95 1525 987796 75765 62423936
C-reactive protein decreased 39.36 11.95 61 989260 906 62498795
Rash erythematous 39.23 11.95 448 988873 42062 62457639
Vaginal haemorrhage 39.05 11.95 259 989062 27228 62472473
Ketoacidosis 39.02 11.95 10 989311 4368 62495333
Ventricular septal defect 39.02 11.95 10 989311 4368 62495333
Transaminases abnormal 39.00 11.95 50 989271 616 62499085
Respiration abnormal 38.97 11.95 26 989295 6391 62493310
Skin lesion 38.83 11.95 684 988637 30037 62469664
Proteinuria 38.65 11.95 160 989161 18985 62480716
Physical disability 38.51 11.95 112 989209 2636 62497065
Iritis 38.50 11.95 123 989198 3052 62496649
Gait disturbance 38.48 11.95 3335 985986 179843 62319858
Oxygen consumption increased 38.42 11.95 7 989314 3877 62495824
Atrial flutter 38.29 11.95 58 989263 9714 62489987
Restless legs syndrome 37.96 11.95 154 989167 18377 62481324
Blood pressure inadequately controlled 37.93 11.95 15 989306 4963 62494738
COVID-19 37.92 11.95 1410 987911 111693 62388008
Haematuria 37.86 11.95 282 989039 28875 62470826
Tonsillar ulcer 37.85 11.95 34 989287 269 62499432
Episcleritis 37.83 11.95 61 989260 939 62498762
Hypoxic-ischaemic encephalopathy 37.81 11.95 10 989311 4277 62495424
Cold sweat 37.81 11.95 82 989239 11965 62487736
Therapy change 37.80 11.95 24 989297 6057 62493644
Bronchial carcinoma 37.78 11.95 53 989268 716 62498985
Cutaneous T-cell lymphoma 37.73 11.95 73 989248 1307 62498394
Application site pruritus 37.69 11.95 8 989313 3976 62495725
Oliguria 37.65 11.95 52 989269 9049 62490652
Product residue present 37.62 11.95 8 989313 3971 62495730
Eye irritation 37.61 11.95 195 989126 21776 62477925
Cerebral toxoplasmosis 37.47 11.95 60 989261 918 62498783
Abortion incomplete 37.42 11.95 3 989318 3128 62496573
Aphasia 37.42 11.95 331 988990 32669 62467032
Multiple drug therapy 37.33 11.95 6 989315 3640 62496061
Device occlusion 37.27 11.95 36 989285 7351 62492350
Joint space narrowing 37.14 11.95 46 989275 546 62499155
Drug screen positive 37.09 11.95 6 989315 3623 62496078
Myelitis 36.88 11.95 73 989248 1330 62498371
Complications of bone marrow transplant 36.87 11.95 41 989280 430 62499271
Leukaemia recurrent 36.85 11.95 71 989250 1267 62498434
Screaming 36.66 11.95 4 989317 3258 62496443
Blood pressure diastolic abnormal 36.57 11.95 367 988954 14175 62485526
Tuberculous pleurisy 36.47 11.95 39 989282 390 62499311
Ileus 36.42 11.95 113 989208 14612 62485089
Blood lactic acid increased 36.37 11.95 34 989287 7052 62492649
Ovarian neoplasm 36.34 11.95 57 989264 856 62498845
Cardiomegaly 36.32 11.95 146 989175 17468 62482233
Encephalitis 36.26 11.95 250 989071 8630 62491071
Blood glucose fluctuation 36.18 11.95 13 989308 4563 62495138
Product use in unapproved indication 36.17 11.95 3251 986070 175829 62323872
Drug dependence 36.15 11.95 228 989093 24255 62475446
Drooling 36.12 11.95 8 989313 3860 62495841
Hepatosplenomegaly 36.11 11.95 106 989215 2508 62497193
Hallucinations, mixed 36.06 11.95 15 989306 4814 62494887
Synostosis 35.89 11.95 18 989303 43 62499658
Squamous cell carcinoma of lung 35.64 11.95 57 989264 871 62498830
Seronegative arthritis 35.61 11.95 139 989182 3820 62495881
Hyperventilation 35.53 11.95 26 989295 6090 62493611
Activated partial thromboplastin time prolonged 35.47 11.95 33 989288 6860 62492841
Rales 35.41 11.95 92 989229 12605 62487096
Faecaloma 35.29 11.95 43 989278 7898 62491803
Haemodialysis 35.16 11.95 53 989268 8894 62490807
Apnoea 35.06 11.95 44 989277 7978 62491723
Bundle branch block left 34.92 11.95 35 989286 7024 62492677
Extrapulmonary tuberculosis 34.85 11.95 34 989287 302 62499399
Small intestinal obstruction 34.73 11.95 157 989164 18180 62481521
Rheumatic disorder 34.55 11.95 116 989205 2956 62496745
Long QT syndrome 34.48 11.95 5 989316 3274 62496427
Visual acuity reduced 34.46 11.95 199 989122 21627 62478074
Injection site urticaria 34.35 11.95 353 988968 13720 62485981
Metastases to central nervous system 34.27 11.95 98 989223 13007 62486694
Intentional product use issue 34.22 11.95 2373 986948 125519 62374182
Psychomotor retardation 34.19 11.95 9 989312 3861 62495840
Skin reaction 34.15 11.95 368 988953 14481 62485220
Visual impairment 34.12 11.95 1028 988293 83418 62416283
White blood cell count increased 33.86 11.95 542 988779 48019 62451682
Eosinophil count increased 33.79 11.95 75 989246 10853 62488848
Post-traumatic stress disorder 33.65 11.95 20 989301 5231 62494470
Ventricular arrhythmia 33.63 11.95 9 989312 3819 62495882
Alveolitis 33.61 11.95 111 989210 2804 62496897
Glaucoma 33.57 11.95 446 988875 18459 62481242
Eczema 33.56 11.95 331 988990 31960 62467741
Ophthalmic herpes zoster 33.51 11.95 89 989232 1984 62497717
Foot fracture 33.34 11.95 541 988780 23373 62476328
Pulmonary sarcoidosis 33.32 11.95 59 989262 984 62498717
Spinal pain 33.24 11.95 332 988989 12807 62486894
Hepatic failure 33.20 11.95 375 988946 35281 62464420
Mucosal toxicity 33.19 11.95 35 989286 344 62499357
Amylase increased 33.10 11.95 30 989291 6315 62493386
Product administration interrupted 33.05 11.95 17 989304 4819 62494882
Blood phosphorus decreased 32.98 11.95 14 989307 4439 62495262
Subarachnoid haemorrhage 32.98 11.95 113 989208 14170 62485531
Application site pain 32.86 11.95 12 989309 4170 62495531
Hypersomnia 32.77 11.95 157 989164 17898 62481803
Pharyngitis streptococcal 32.71 11.95 281 989040 10391 62489310
Injection site rash 32.69 11.95 442 988879 18367 62481334
Small for dates baby 32.61 11.95 9 989312 3742 62495959
International normalised ratio abnormal 32.59 11.95 6 989315 3298 62496403
Tibia fracture 32.53 11.95 162 989159 4958 62494743
Peripheral coldness 32.53 11.95 90 989231 12075 62487626
Arachnoiditis 32.50 11.95 33 989288 309 62499392
Vascular access complication 32.30 11.95 89 989232 2029 62497672
Polyuria 32.24 11.95 52 989269 8490 62491211
Joint laxity 32.23 11.95 98 989223 2366 62497335
Hypertonia 32.14 11.95 16 989305 4621 62495080
Choking 32.05 11.95 66 989255 9813 62489888
Failure to thrive 31.97 11.95 39 989282 7159 62492542
Haemorrhagic stroke 31.90 11.95 26 989295 5766 62493935
Brain natriuretic peptide increased 31.83 11.95 21 989300 5192 62494509
Toxic skin eruption 31.78 11.95 99 989222 12786 62486915
Traumatic lung injury 31.78 11.95 74 989247 1515 62498186
X-ray abnormal 31.75 11.95 226 989095 7884 62491817
Arthritis infective 31.75 11.95 191 989130 6287 62493414
Tendon disorder 31.71 11.95 177 989144 5666 62494035
Septic arthritis staphylococcal 31.70 11.95 38 989283 435 62499266
Cardiac murmur 31.69 11.95 118 989203 14434 62485267
Aspiration bone marrow abnormal 31.65 11.95 15 989306 30 62499671
Azotaemia 31.64 11.95 15 989306 4456 62495245
Peripheral T-cell lymphoma unspecified 31.60 11.95 26 989295 180 62499521
Cutaneous vasculitis 31.58 11.95 164 989157 5105 62494596
Lung neoplasm malignant 31.55 11.95 455 988866 19178 62480523
Ankle arthroplasty 31.52 11.95 80 989241 1733 62497968
Bunion operation 31.45 11.95 66 989255 1256 62498445
Intervertebral disc protrusion 31.45 11.95 532 988789 23177 62476524
Malignant melanoma in situ 31.44 11.95 54 989267 878 62498823
Asphyxia 31.33 11.95 30 989291 6151 62493550
Ataxia 31.30 11.95 126 989195 15069 62484632
Pyrexia 31.27 11.95 6667 982654 463811 62035890
Viral upper respiratory tract infection 31.27 11.95 217 989104 7507 62492194
Synovial disorder 31.25 11.95 86 989235 1959 62497742
Bicytopenia 31.25 11.95 98 989223 2407 62497294
Cancer pain 31.23 11.95 6 989315 3199 62496502
Arteriosclerosis 31.19 11.95 69 989252 9997 62489704
Incontinence 31.14 11.95 86 989235 11546 62488155
Embolic stroke 31.12 11.95 10 989311 3766 62495935
Infection reactivation 31.05 11.95 62 989259 1137 62498564
Weight decreased 30.95 11.95 3808 985513 272990 62226711
Acute pulmonary histoplasmosis 30.88 11.95 22 989299 119 62499582
Extra dose administered 30.83 11.95 32 989289 6318 62493383
Ear pain 30.82 11.95 759 988562 35359 62464342
Pyoderma gangrenosum 30.78 11.95 125 989196 3500 62496201
Inhibitory drug interaction 30.77 11.95 4 989317 2845 62496856
Hyperlactacidaemia 30.77 11.95 4 989317 2845 62496856
Epstein-Barr virus antigen positive 30.73 11.95 15 989306 33 62499668
Multiple sclerosis 30.57 11.95 238 989083 24134 62475567
Respiratory tract congestion 30.56 11.95 418 988903 17414 62482287
Product prescribing error 30.56 11.95 262 989059 26027 62473674
Pain in jaw 30.48 11.95 485 988836 43011 62456690
Aplasia pure red cell 30.32 11.95 16 989305 4471 62495230
Rash macular 30.32 11.95 226 989095 23138 62476563
Mycobacterial infection 30.30 11.95 78 989243 1705 62497996
Catheterisation cardiac 30.25 11.95 17 989304 4586 62495115
Colon cancer 30.23 11.95 260 989061 9618 62490083
Lung transplant 30.17 11.95 6 989315 3122 62496579
Urine abnormality 30.16 11.95 39 989282 6980 62492721
Polycystic ovaries 30.13 11.95 16 989305 4455 62495246
Mood swings 30.10 11.95 164 989157 18084 62481617
Leishmaniasis 30.10 11.95 18 989303 68 62499633
Diplopia 30.09 11.95 231 989090 23497 62476204
Skin papilloma 30.01 11.95 155 989166 4814 62494887
Sarcoidosis 29.97 11.95 202 989119 6920 62492781
Eyelid oedema 29.94 11.95 75 989246 10404 62489297
Device leakage 29.90 11.95 40 989281 7056 62492645
Performance status decreased 29.85 11.95 10 989311 3668 62496033
Coma scale abnormal 29.82 11.95 22 989299 5131 62494570
Blood bicarbonate decreased 29.75 11.95 5 989316 2936 62496765
Clostridium difficile infection 29.74 11.95 310 989011 29612 62470089
Hepatitis B 29.67 11.95 128 989193 3684 62496017
Feeling cold 29.62 11.95 234 989087 23654 62476047
Varicella 29.57 11.95 81 989240 1840 62497861
Lacrimation increased 29.51 11.95 194 989127 20437 62479264
Plasma cell myeloma recurrent 29.30 11.95 7 989314 3206 62496495
Urticarial vasculitis 29.29 11.95 44 989277 635 62499066
Toe operation 28.90 11.95 47 989274 729 62498972
Myocardial ischaemia 28.84 11.95 103 989218 12756 62486945
Sexual dysfunction 28.79 11.95 16 989305 4343 62495358
Angioimmunoblastic T-cell lymphoma stage IV 28.60 11.95 9 989312 0 62499701
Secretion discharge 28.54 11.95 304 989017 11927 62487774
Pulse absent 28.52 11.95 25 989296 5349 62494352
Pemphigoid 28.38 11.95 44 989277 7300 62492401
Immune thrombocytopenia 28.29 11.95 78 989243 10478 62489223
Stress cardiomyopathy 28.29 11.95 66 989255 9384 62490317
Mycobacterium avium complex infection 28.25 11.95 109 989212 2979 62496722
Anaphylactic shock 28.16 11.95 234 989087 23399 62476302
Enterovirus test positive 28.16 11.95 22 989299 140 62499561
Obsessive-compulsive disorder 28.15 11.95 14 989307 4046 62495655
Skin exfoliation 28.11 11.95 487 988834 42615 62457086
Heavy menstrual bleeding 28.09 11.95 162 989159 17611 62482090
Bundle branch block right 28.07 11.95 22 989299 4976 62494725
Blood cholesterol increased 28.06 11.95 1761 987560 92271 62407430
Blood chloride decreased 27.97 11.95 27 989294 5515 62494186
Epstein-Barr virus infection reactivation 27.93 11.95 47 989274 751 62498950
Blood thyroid stimulating hormone increased 27.90 11.95 43 989278 7151 62492550
Ovarian cancer 27.90 11.95 174 989147 5802 62493899
Bronchitis 27.87 11.95 2285 987036 122650 62377051
Infective tenosynovitis 27.83 11.95 30 989291 303 62499398
Galactorrhoea 27.81 11.95 15 989306 4140 62495561
Hypokinesia 27.80 11.95 117 989204 13819 62485882
Gastric disorder 27.74 11.95 771 988550 36598 62463103
Pruritus allergic 27.71 11.95 70 989251 1512 62498189
Antibody test positive 27.64 11.95 99 989222 2608 62497093
Ulcerative keratitis 27.58 11.95 99 989222 2611 62497090
Viral vasculitis 27.57 11.95 15 989306 45 62499656
Emotional disorder 27.52 11.95 111 989210 13268 62486433
Blood pressure diastolic decreased 27.44 11.95 502 988819 22204 62477497
Ear infection 27.41 11.95 785 988536 37428 62462273
Tongue neoplasm malignant stage unspecified 27.30 11.95 48 989273 796 62498905
Dermatomyositis 27.27 11.95 102 989219 2746 62496955
Rotator cuff syndrome 27.16 11.95 326 988995 13176 62486525
Tumour marker increased 27.15 11.95 22 989299 4893 62494808
Pulmonary arterial pressure increased 27.11 11.95 11 989310 3584 62496117
Epstein-Barr viraemia 27.09 11.95 53 989268 957 62498744
Feeling jittery 27.07 11.95 112 989209 13291 62486410
Apoptotic colonopathy 27.03 11.95 12 989309 19 62499682
Rheumatic fever 27.01 11.95 871 988450 42240 62457461
Anal abscess 26.95 11.95 143 989178 4489 62495212
Eye movement disorder 26.94 11.95 25 989296 5203 62494498
Oral mucosa erosion 26.92 11.95 58 989263 1125 62498576
Post procedural haemorrhage 26.87 11.95 52 989269 7912 62491789
Squamous cell carcinoma 26.83 11.95 228 989093 8404 62491297
Human rhinovirus test positive 26.80 11.95 23 989298 170 62499531
Lower respiratory tract infection viral 26.76 11.95 50 989271 871 62498830
Nocturia 26.74 11.95 54 989267 8087 62491614
Diffuse large B-cell lymphoma stage III 26.70 11.95 14 989307 38 62499663
Liver injury 26.68 11.95 1176 988145 59344 62440357
Joint lock 26.64 11.95 88 989233 2223 62497478
Malnutrition 26.63 11.95 135 989186 15163 62484538
Colitis ischaemic 26.61 11.95 82 989239 10626 62489075
Hyperthermia 26.58 11.95 65 989256 9091 62490610
Neoplasm recurrence 26.53 11.95 96 989225 2542 62497159
Carpal tunnel syndrome 26.49 11.95 464 988857 20353 62479348
Abortion induced 26.48 11.95 77 989244 10165 62489536
Dysphoria 26.48 11.95 23 989298 4943 62494758
Wheelchair user 26.45 11.95 179 989142 6140 62493561
Craniosynostosis 26.44 11.95 22 989299 155 62499546
Metastases to liver 26.41 11.95 238 989083 23401 62476300
Coccidioidomycosis 26.36 11.95 51 989270 913 62498788
Anaplastic large-cell lymphoma 26.34 11.95 18 989303 90 62499611
Medical device site joint infection 26.33 11.95 27 989294 256 62499445
Large granular lymphocytosis 26.29 11.95 23 989298 175 62499526
Haemolytic anaemia 26.26 11.95 76 989245 10049 62489652
Joint warmth 26.26 11.95 66 989255 1421 62498280
Knee deformity 26.20 11.95 62 989259 1283 62498418
Anaemia macrocytic 26.14 11.95 115 989206 3339 62496362
Haemodynamic instability 26.08 11.95 66 989255 9124 62490577
Synovial rupture 25.89 11.95 25 989296 219 62499482
Cystitis haemorrhagic 25.87 11.95 130 989191 3993 62495708
Laboratory test abnormal 25.86 11.95 281 989040 26631 62473070
Self-injurious ideation 25.86 11.95 5 989316 2654 62497047
Angina pectoris 25.83 11.95 322 988999 29756 62469945
Bone tuberculosis 25.67 11.95 24 989297 201 62499500
Palindromic rheumatism 25.67 11.95 24 989297 201 62499500
Purpura 25.66 11.95 91 989230 11294 62488407
Isosporiasis 25.66 11.95 13 989308 32 62499669
Cerebral infarction 25.64 11.95 243 989078 23650 62476051
Tooth infection 25.58 11.95 407 988914 17513 62482188
Bloody discharge 25.49 11.95 67 989254 1484 62498217
Coordination abnormal 25.44 11.95 119 989202 13654 62486047
Disease recurrence 25.42 11.95 594 988727 27436 62472265
Infusion site bruising 25.41 11.95 14 989307 3818 62495883
Hypoventilation 25.37 11.95 22 989299 4732 62494969
Abdominal wall haematoma 25.34 11.95 8 989313 3047 62496654
Lymphoedema 25.33 11.95 95 989226 11597 62488104
Blood albumin decreased 25.31 11.95 131 989190 14635 62485066
Tooth abscess 25.29 11.95 350 988971 14619 62485082
Intertrigo 25.27 11.95 39 989282 577 62499124
Exercise tolerance decreased 25.25 11.95 29 989292 5468 62494233
Antinuclear antibody positive 25.25 11.95 212 989109 7787 62491914
Limb operation 25.23 11.95 127 989194 3904 62495797
Carcinoma in situ of skin 25.22 11.95 24 989297 206 62499495
Catheter site haemorrhage 25.14 11.95 9 989312 3166 62496535
Cartilage atrophy 25.02 11.95 21 989300 150 62499551
Lung squamous cell carcinoma recurrent 25.00 11.95 10 989311 10 62499691
Cytomegalovirus infection reactivation 24.90 11.95 125 989196 3838 62495863
Hypophagia 24.87 11.95 340 988981 30919 62468782
Blood pressure diastolic increased 24.87 11.95 252 989069 9758 62489943
Cardiomyopathy 24.82 11.95 166 989155 17418 62482283
Haemorrhoids 24.75 11.95 223 989098 21927 62477774
Catheter site infection 24.73 11.95 24 989297 4890 62494811
Abdominal pain lower 24.72 11.95 268 989053 25410 62474291
Inflammatory pain 24.64 11.95 48 989273 864 62498837
Sudden death 24.58 11.95 82 989239 10367 62489334
Appetite disorder 24.53 11.95 48 989273 7273 62492428
Faecal calprotectin increased 24.51 11.95 107 989214 3096 62496605
Borrelia infection 24.47 11.95 25 989296 236 62499465
Varicella zoster pneumonia 24.37 11.95 13 989308 37 62499664
Red blood cell sedimentation rate 24.36 11.95 144 989177 4710 62494991
Rheumatoid vasculitis 24.25 11.95 29 989292 331 62499370
Refusal of treatment by patient 24.18 11.95 30 989291 5467 62494234
Infected dermal cyst 24.17 11.95 33 989288 434 62499267
Squamous cell carcinoma of the oral cavity 24.15 11.95 27 989294 285 62499416
Granulomatosis with polyangiitis 24.13 11.95 84 989237 2181 62497520
Exostosis 24.13 11.95 402 988919 17460 62482241
Acute graft versus host disease in liver 24.13 11.95 40 989281 631 62499070
Sleep terror 24.12 11.95 6 989315 2674 62497027
Ganglioneuroma 24.07 11.95 19 989302 123 62499578
Low turnover osteopathy 24.04 11.95 18 989303 4167 62495534
Hepatitis B virus test positive 24.03 11.95 23 989298 199 62499502
Overlap syndrome 24.01 11.95 47 989274 849 62498852
Granuloma 24.00 11.95 163 989158 5598 62494103
Angioimmunoblastic T-cell lymphoma 24.00 11.95 17 989304 91 62499610
Injection site inflammation 24.00 11.95 121 989200 3722 62495979
Growth failure 23.98 11.95 28 989293 311 62499390
Cardioactive drug level increased 23.97 11.95 3 989318 2197 62497504
Inadequate analgesia 23.89 11.95 8 989313 2935 62496766
Rheumatoid factor 23.78 11.95 28 989293 314 62499387
Urine ketone body present 23.73 11.95 5 989316 2498 62497203
Electrocardiogram ST segment elevation 23.73 11.95 16 989305 3911 62495790
Myelodysplastic syndrome 23.72 11.95 380 988941 16374 62483327
Initial insomnia 23.69 11.95 37 989284 6120 62493581
Hypoacusis 23.68 11.95 251 989070 23900 62475801
Application site rash 23.67 11.95 5 989316 2493 62497208
Laryngeal disorder 23.61 11.95 51 989270 991 62498710
Anaemia megaloblastic 23.59 11.95 32 989289 418 62499283
Diffuse large B-cell lymphoma stage II 23.58 11.95 14 989307 52 62499649
Dermatitis contact 23.49 11.95 90 989231 10918 62488783
Epstein-Barr virus test positive 23.47 11.95 38 989283 587 62499114
Cross sensitivity reaction 23.43 11.95 3 989318 2159 62497542
Disease susceptibility 23.37 11.95 22 989299 186 62499515
Nystagmus 23.34 11.95 38 989283 6182 62493519
Dermatitis acneiform 23.34 11.95 26 989295 4970 62494731
Middle lobe syndrome 23.29 11.95 12 989309 31 62499670
Incorrect dosage administered 23.29 11.95 78 989243 1985 62497716
Major depression 23.21 11.95 57 989264 7961 62491740
Total lung capacity increased 23.21 11.95 4 989317 2306 62497395
Cholestatic liver injury 23.19 11.95 6 989315 2604 62497097
Tension headache 23.14 11.95 28 989293 5158 62494543
Blood triglycerides increased 23.01 11.95 108 989213 12380 62487321
Tubal rupture 23.00 11.95 9 989312 8 62499693
Snoring 22.97 11.95 19 989302 4183 62495518
Blood sodium increased 22.94 11.95 7 989314 2725 62496976
Biliary dyskinesia 22.90 11.95 7 989314 2722 62496979
Cytomegalovirus infection 22.85 11.95 456 988865 20496 62479205
Acute pulmonary oedema 22.84 11.95 59 989262 8099 62491602
Central nervous system lymphoma 22.79 11.95 63 989258 1439 62498262
Gastrointestinal toxicity 22.78 11.95 202 989119 7539 62492162
Eructation 22.77 11.95 61 989260 8272 62491429
Nail psoriasis 22.76 11.95 38 989283 603 62499098
Mean platelet volume decreased 22.63 11.95 92 989229 2577 62497124
Ankle operation 22.60 11.95 57 989264 1230 62498471
Anticipatory anxiety 22.59 11.95 56 989265 1195 62498506
T-cell lymphoma 22.58 11.95 39 989282 637 62499064
Swollen joint count increased 22.48 11.95 728 988593 35326 62464375
Alcohol interaction 22.46 11.95 5 989316 2404 62497297
Blood thyroid stimulating hormone decreased 22.43 11.95 23 989298 4567 62495134
Adverse event 22.38 11.95 1277 988044 66282 62433419
Humoral immune defect 22.37 11.95 24 989297 241 62499460
Red cell distribution width decreased 22.36 11.95 77 989244 1988 62497713
Breast cancer stage II 22.35 11.95 66 989255 8670 62491031
Cutaneous tuberculosis 22.29 11.95 19 989302 139 62499562
Alcohol use 22.26 11.95 3 989318 2076 62497625
Osteophyte fracture 22.24 11.95 7 989314 0 62499701
Therapeutic response unexpected 22.23 11.95 186 989135 18573 62481128
Pleuropericarditis 22.22 11.95 24 989297 243 62499458
Cardiac failure acute 22.22 11.95 75 989246 9448 62490253
Malignant peritoneal neoplasm 22.19 11.95 40 989281 677 62499024
Cryptococcosis 22.18 11.95 53 989268 1104 62498597
Ocular sarcoidosis 22.15 11.95 13 989308 47 62499654
Intervertebral disc space narrowing 22.15 11.95 50 989271 1002 62498699
Osteochondrosis 22.14 11.95 59 989262 1318 62498383
Cardiac pacemaker insertion 22.13 11.95 19 989302 4107 62495594
Growth retardation 22.11 11.95 58 989263 1283 62498418
Abscess 22.10 11.95 374 988947 16294 62483407
Ammonia increased 22.00 11.95 24 989297 4632 62495069
Pharyngeal ulceration 21.93 11.95 44 989277 810 62498891
Sciatica 21.90 11.95 695 988626 33629 62466072
Logorrhoea 21.87 11.95 6 989315 2504 62497197
Amenorrhoea 21.84 11.95 80 989241 9834 62489867
Body height decreased 21.76 11.95 82 989239 9996 62489705
Nodular melanoma 21.76 11.95 13 989308 49 62499652
Clostridium difficile colitis 21.73 11.95 210 989111 20359 62479342
Catheter site pain 21.73 11.95 25 989296 4710 62494991
Mixed liver injury 21.73 11.95 25 989296 4710 62494991
Dysphonia 21.69 11.95 570 988751 47044 62452657
Hypertension 21.68 11.95 3926 985395 275377 62224324
Laryngospasm 21.67 11.95 10 989311 3018 62496683
Ocular hyperaemia 21.66 11.95 269 989052 24875 62474826
Device use issue 21.61 11.95 7 989314 2623 62497078
Encephalitis fungal 21.59 11.95 12 989309 38 62499663
Atelectasis 21.58 11.95 222 989099 21261 62478440
Lip and/or oral cavity cancer 21.56 11.95 45 989276 853 62498848
Therapeutic product effect delayed 21.55 11.95 84 989237 2307 62497394
Pelvic pain 21.48 11.95 123 989198 13396 62486305
Pneumonia viral 21.42 11.95 203 989118 7719 62491982
Sensory disturbance 21.40 11.95 125 989196 13547 62486154
Electrocardiogram ST segment depression 21.38 11.95 9 989312 2868 62496833
Tongue ulceration 21.37 11.95 111 989210 3455 62496246
Catheter site discharge 21.33 11.95 3 989318 2010 62497691
Device physical property issue 21.31 11.95 3 989318 2009 62497692
Haemolysis 21.30 11.95 46 989275 6722 62492979
Bone density decreased 21.29 11.95 333 988988 14279 62485422
Electrocardiogram T wave inversion 21.28 11.95 14 989307 3467 62496234
Tongue oedema 21.28 11.95 24 989297 4562 62495139
Subdural haemorrhage 21.25 11.95 11 989310 3107 62496594
Social avoidant behaviour 21.18 11.95 10 989311 2978 62496723
Crying 21.15 11.95 247 989074 23096 62476605
Lung cancer metastatic 21.14 11.95 88 989233 2492 62497209
Language disorder 21.14 11.95 4 989317 2156 62497545
Device loosening 21.10 11.95 31 989290 438 62499263
Tearfulness 21.08 11.95 20 989301 4119 62495582
Paradoxical psoriasis 21.03 11.95 22 989299 214 62499487
Generalised oedema 21.01 11.95 152 989169 15666 62484035
Atrial tachycardia 21.00 11.95 21 989300 4219 62495482
Prosthesis user 20.95 11.95 14 989307 67 62499634
Implant site pain 20.94 11.95 6 989315 2434 62497267
Petit mal epilepsy 20.93 11.95 17 989304 3777 62495924
Acquired claw toe 20.90 11.95 21 989300 194 62499507
Abdominal pain upper 20.88 11.95 2858 986463 203586 62296115
Cervix carcinoma stage 0 20.86 11.95 27 989294 336 62499365
Osteomyelitis 20.78 11.95 542 988779 25478 62474223
Neoplasm malignant 20.75 11.95 611 988710 29250 62470451
Vitamin D deficiency 20.70 11.95 129 989192 13763 62485938
Incoherent 20.70 11.95 24 989297 4506 62495195
Skin tightness 20.67 11.95 22 989299 4294 62495407
Blood glucose abnormal 20.65 11.95 59 989262 7833 62491868
Oral disorder 20.63 11.95 220 989101 8634 62491067
Congestive hepatopathy 20.62 11.95 10 989311 2932 62496769
Peptic ulcer haemorrhage 20.56 11.95 49 989272 1019 62498682
Colorectal cancer 20.53 11.95 16 989305 3629 62496072
Chronic recurrent multifocal osteomyelitis 20.53 11.95 12 989309 43 62499658
Bradyarrhythmia 20.52 11.95 4 989317 2111 62497590
Back pain 20.49 11.95 3713 985608 260432 62239269
Drug level increased 20.43 11.95 241 989080 22495 62477206
Lyme disease 20.43 11.95 107 989214 3342 62496359
Double stranded DNA antibody positive 20.42 11.95 26 989295 318 62499383
Shock haemorrhagic 20.41 11.95 82 989239 9813 62489888
Plasmablastic lymphoma 20.41 11.95 21 989300 200 62499501
Exposure to communicable disease 20.38 11.95 35 989286 569 62499132
Dyspepsia 20.34 11.95 1345 987976 100851 62398850
Oropharyngeal cancer 20.33 11.95 12 989309 44 62499657
Myelitis transverse 20.27 11.95 54 989267 1206 62498495
Eye infection toxoplasmal 20.26 11.95 24 989297 271 62499430
Meningoencephalitis herpetic 20.24 11.95 53 989268 1171 62498530
Meningitis coccidioides 20.19 11.95 10 989311 23 62499678
Mycotic allergy 20.16 11.95 47 989274 963 62498738
Steatohepatitis 20.14 11.95 36 989285 605 62499096
Multiple allergies 20.14 11.95 129 989192 13673 62486028
Oropharyngeal pain 20.09 11.95 1722 987599 92765 62406936
Chondropathy 20.08 11.95 80 989241 2220 62497481
Salivary gland cancer 20.06 11.95 19 989302 162 62499539
Secondary immunodeficiency 19.99 11.95 57 989264 1326 62498375
Chemotherapeutic drug level above therapeutic 19.94 11.95 12 989309 46 62499655
Tender joint count increased 19.94 11.95 12 989309 46 62499655
Metastatic bronchial carcinoma 19.87 11.95 16 989305 107 62499594
Product taste abnormal 19.87 11.95 4 989317 2063 62497638
Ectrodactyly 19.79 11.95 7 989314 3 62499698
Asthma-chronic obstructive pulmonary disease overlap syndrome 19.78 11.95 4 989317 2057 62497644
Bipolar disorder 19.75 11.95 61 989260 7899 62491802
Eye pain 19.74 11.95 390 988931 33464 62466237
Inability to afford medication 19.73 11.95 6 989315 2341 62497360
Thrombosis in device 19.71 11.95 11 989310 2979 62496722
Mass excision 19.71 11.95 26 989295 330 62499371
Diverticular perforation 19.69 11.95 108 989213 3434 62496267
Brain injury 19.67 11.95 51 989270 6992 62492709
Haematochezia 19.65 11.95 660 988661 52884 62446817
Tender joint count 19.64 11.95 21 989300 210 62499491
Legionella infection 19.63 11.95 30 989291 440 62499261
Micturition urgency 19.60 11.95 80 989241 9531 62490170
Duodenal ulcer 19.55 11.95 59 989262 7697 62492004
Abscess sweat gland 19.53 11.95 8 989313 9 62499692
Nail disorder 19.49 11.95 298 989023 12717 62486984
Body temperature decreased 19.49 11.95 434 988887 19885 62479816
Listeriosis 19.43 11.95 60 989261 1461 62498240
Post procedural infection 19.43 11.95 227 989094 9115 62490586
Female genital tract fistula 19.42 11.95 57 989264 7502 62492199
Sputum increased 19.42 11.95 7 989314 2452 62497249
Superior sagittal sinus thrombosis 19.41 11.95 40 989281 751 62498950
Metatarsalgia 19.40 11.95 23 989298 260 62499441
Laryngitis fungal 19.37 11.95 17 989304 130 62499571
Protein total decreased 19.33 11.95 40 989281 5937 62493764
Attention deficit hyperactivity disorder 19.31 11.95 12 989309 3064 62496637
Disseminated sporotrichosis 19.31 11.95 9 989312 17 62499684
Electrocardiogram T wave abnormal 19.27 11.95 7 989314 2440 62497261
Coronary arterial stent insertion 19.25 11.95 10 989311 2819 62496882
Hydronephrosis 19.18 11.95 93 989228 10569 62489132
Hypovolaemic shock 19.16 11.95 43 989278 6198 62493503
Nephrogenic anaemia 19.15 11.95 5 989316 2157 62497544
Arthritis viral 19.06 11.95 6 989315 0 62499701
Hepatic steato-fibrosis 19.06 11.95 6 989315 0 62499701
Respiratory tract ulceration 19.06 11.95 6 989315 0 62499701
Oropharyngeal discolouration 19.06 11.95 6 989315 0 62499701
Hyperuricaemia 19.06 11.95 34 989287 5336 62494365
Extrasystoles 18.92 11.95 32 989289 5128 62494573
Bedridden 18.92 11.95 259 989062 10792 62488909
Product label confusion 18.92 11.95 67 989254 1755 62497946
Malignant neoplasm of conjunctiva 18.90 11.95 11 989310 39 62499662
Perineal infection 18.88 11.95 17 989304 135 62499566
Flank pain 18.87 11.95 164 989157 16246 62483455
Maternal exposure during breast feeding 18.81 11.95 23 989298 4218 62495483
Keratitis 18.80 11.95 104 989217 3318 62496383
Rectal cancer 18.79 11.95 75 989246 2083 62497618
Guttate psoriasis 18.75 11.95 29 989292 430 62499271
Breast cancer metastatic 18.75 11.95 110 989211 11908 62487793
Infiltration anaesthesia 18.70 11.95 19 989302 178 62499523
Glioma 18.70 11.95 24 989297 296 62499405
Diffuse alopecia 18.69 11.95 43 989278 873 62498828
Hair follicle tumour benign 18.69 11.95 28 989293 403 62499298
Wernicke's encephalopathy 18.68 11.95 9 989312 19 62499682
Lung squamous cell carcinoma stage I 18.67 11.95 8 989313 11 62499690
Reactive gastropathy 18.65 11.95 29 989292 432 62499269
Expired product administered 18.64 11.95 43 989278 6138 62493563
Oesophagitis 18.61 11.95 147 989174 14861 62484840
Psychiatric symptom 18.60 11.95 33 989288 5190 62494511
Alcoholism 18.59 11.95 3 989318 1815 62497886
Immune-mediated enterocolitis 18.48 11.95 5 989316 2106 62497595
JC virus infection 18.44 11.95 72 989249 1979 62497722
Genital infection 18.44 11.95 18 989303 160 62499541
Central nervous system lesion 18.42 11.95 94 989227 10541 62489160
Mononeuritis 18.38 11.95 10 989311 30 62499671
Subdural abscess 18.38 11.95 10 989311 30 62499671
Gout 18.37 11.95 126 989195 13145 62486556
Hypermobility syndrome 18.33 11.95 40 989281 783 62498918
Multiple injuries 18.32 11.95 3 989318 1795 62497906
Eczema infected 18.31 11.95 11 989310 42 62499659
Premature rupture of membranes 18.28 11.95 31 989290 4962 62494739
Sinus arrest 18.26 11.95 4 989317 1945 62497756
Infusion site infection 18.26 11.95 3 989318 1791 62497910
Small intestinal haemorrhage 18.23 11.95 5 989316 2087 62497614
Dyspnoea at rest 18.22 11.95 22 989299 4057 62495644
Gastrointestinal lymphoma 18.18 11.95 12 989309 56 62499645
Pelvic floor muscle weakness 18.18 11.95 12 989309 56 62499645
Breast abscess 18.18 11.95 65 989256 1711 62497990
Neck mass 18.15 11.95 107 989214 3496 62496205
Bone disorder 18.14 11.95 448 988873 20878 62478823
Rheumatoid arthritis-associated interstitial lung disease 18.10 11.95 15 989306 105 62499596
Upper-airway cough syndrome 18.08 11.95 104 989217 11314 62488387
Cubital tunnel syndrome 18.08 11.95 23 989298 281 62499420
Blood urine present 18.05 11.95 149 989172 14920 62484781
Torus fracture 18.04 11.95 17 989304 144 62499557
Joint ankylosis 18.03 11.95 46 989275 1000 62498701
Hypergammaglobulinaemia benign monoclonal 18.01 11.95 38 989283 726 62498975
Diastolic dysfunction 17.96 11.95 47 989274 6424 62493277
Cervical dysplasia 17.87 11.95 98 989223 3116 62496585
Angina unstable 17.87 11.95 54 989267 7041 62492660
Cyst 17.84 11.95 314 989007 13785 62485916
Blood pH decreased 17.82 11.95 9 989312 2578 62497123
Ileal stenosis 17.79 11.95 63 989258 1650 62498051
Interferon gamma release assay positive 17.75 11.95 11 989310 45 62499656
Portal tract inflammation 17.70 11.95 10 989311 33 62499668
Cardiospasm 17.70 11.95 4 989317 1903 62497798
Folate deficiency 17.67 11.95 81 989240 2394 62497307
Hypoglycaemic coma 17.67 11.95 9 989312 2566 62497135
Empyema 17.67 11.95 71 989250 1978 62497723
Carbohydrate antigen 125 increased 17.66 11.95 11 989310 2805 62496896
Herpes simplex 17.66 11.95 202 989119 8069 62491632
Application site irritation 17.65 11.95 3 989318 1747 62497954
Mucormycosis 17.65 11.95 90 989231 2781 62496920
Anal stenosis 17.64 11.95 28 989293 425 62499276
International normalised ratio fluctuation 17.62 11.95 81 989240 2397 62497304
Musculoskeletal chest pain 17.62 11.95 227 989094 20856 62478845
Psoriasis area severity index increased 17.56 11.95 12 989309 60 62499641
Rib fracture 17.54 11.95 247 989074 22350 62477351
Lichen myxoedematosus 17.54 11.95 9 989312 23 62499678
Metabolic disorder 17.47 11.95 48 989273 6455 62493246
Iron deficiency anaemia 17.44 11.95 213 989108 19756 62479945
Decreased interest 17.44 11.95 15 989306 3239 62496462
Pleural fibrosis 17.42 11.95 103 989218 3369 62496332
Cerebral haematoma 17.39 11.95 19 989302 3664 62496037
Immunodeficiency 17.39 11.95 426 988895 19828 62479873
Road traffic accident 17.36 11.95 436 988885 36196 62463505
Body temperature increased 17.35 11.95 727 988594 36465 62463236
N-terminal prohormone brain natriuretic peptide increased 17.33 11.95 6 989315 2155 62497546
Gastrointestinal inflammation 17.32 11.95 148 989173 5464 62494237
Multiple fractures 17.30 11.95 208 989113 8410 62491291
Throat clearing 17.29 11.95 8 989313 2411 62497290
Euphoric mood 17.29 11.95 31 989290 4856 62494845
Limb fracture 17.28 11.95 9 989312 24 62499677
Supraventricular extrasystoles 17.26 11.95 28 989293 4561 62495140
Poor venous access 17.21 11.95 325 988996 14460 62485241
Chondrocalcinosis 17.21 11.95 40 989281 818 62498883
Pyomyositis 17.18 11.95 25 989296 350 62499351
Blood pressure increased 17.17 11.95 2237 987084 159825 62339876
Lymphadenopathy 17.11 11.95 748 988573 37710 62461991
Decubitus ulcer 17.10 11.95 95 989226 10425 62489276
Diabetic metabolic decompensation 17.09 11.95 3 989318 1707 62497994
Incorrect drug administration rate 17.04 11.95 22 989299 3940 62495761
Mucosal disorder 17.01 11.95 73 989248 2096 62497605
Crystal nephropathy 17.01 11.95 42 989279 894 62498807
Endometrial adenocarcinoma 16.96 11.95 50 989271 1186 62498515
Medial tibial stress syndrome 16.96 11.95 15 989306 116 62499585
Infusion site rash 16.94 11.95 5 989316 1989 62497712
Pulmonary function test decreased 16.89 11.95 22 989299 3925 62495776
Bronchopulmonary aspergillosis allergic 16.88 11.95 7 989314 2251 62497450
Quadriplegia 16.85 11.95 64 989257 1736 62497965
Bronchiectasis 16.83 11.95 349 988972 15793 62483908
Economic problem 16.83 11.95 5 989316 1981 62497720
Hip surgery 16.83 11.95 99 989222 3232 62496469
Injection site irritation 16.82 11.95 134 989187 4844 62494857
Hepatic function abnormal 16.82 11.95 445 988876 36697 62463004
Back injury 16.78 11.95 227 989094 9433 62490268
Communication disorder 16.77 11.95 9 989312 2491 62497210
Soft tissue swelling 16.76 11.95 50 989271 1194 62498507
Axial spondyloarthritis 16.73 11.95 25 989296 359 62499342
Gallbladder necrosis 16.68 11.95 6 989315 3 62499698
Lip oedema 16.66 11.95 22 989299 3902 62495799
Drug-device interaction 16.61 11.95 13 989308 83 62499618
Foreign body sensation in eyes 16.58 11.95 7 989314 2227 62497474
Cardiac failure chronic 16.57 11.95 27 989294 4391 62495310
Product monitoring error 16.57 11.95 28 989293 4488 62495213
Anaplastic thyroid cancer 16.57 11.95 8 989313 17 62499684
Abscess bacterial 16.55 11.95 19 989302 207 62499494
Iris adhesions 16.54 11.95 23 989298 308 62499393
Brachiocephalic artery stenosis 16.54 11.95 9 989312 27 62499674
Bone density abnormal 16.53 11.95 100 989221 3298 62496403
Idiopathic pneumonia syndrome 16.50 11.95 24 989297 336 62499365
Cervix carcinoma 16.48 11.95 92 989229 2945 62496756
Respiratory disorder 16.48 11.95 756 988565 38326 62461375
Blood lactate dehydrogenase increased 16.45 11.95 257 989064 22859 62476842
Sluggishness 16.42 11.95 36 989285 5233 62494468
Fear-related avoidance of activities 16.38 11.95 15 989306 122 62499579
Gastritis 16.35 11.95 449 988872 36854 62462847
Internal haemorrhage 16.34 11.95 35 989286 5130 62494571
Pancreatitis 16.33 11.95 612 988709 48443 62451258
Malignant neoplasm of ampulla of Vater 16.31 11.95 9 989312 28 62499673
Product prescribing issue 16.31 11.95 11 989310 2688 62497013
Blepharospasm 16.30 11.95 44 989277 5952 62493749
Thyroid cancer 16.29 11.95 146 989175 5465 62494236
Herpes zoster meningitis 16.29 11.95 12 989309 69 62499632
Transplant dysfunction 16.27 11.95 32 989289 4840 62494861
Exposed bone in jaw 16.27 11.95 13 989308 2912 62496789
Cough 16.25 11.95 4183 985138 288560 62211141
Temperature intolerance 16.24 11.95 78 989243 8886 62490815
Apathy 16.23 11.95 76 989245 8718 62490983
Medical device discomfort 16.22 11.95 5 989316 1934 62497767
Tonsil cancer 16.21 11.95 19 989302 212 62499489
Electroencephalogram abnormal 16.20 11.95 20 989301 3652 62496049
Neoscytalidium infection 16.19 11.95 7 989314 10 62499691
Pharyngeal abscess 16.18 11.95 21 989300 262 62499439
Nodal osteoarthritis 16.18 11.95 39 989282 817 62498884
Diabetic retinopathy 16.17 11.95 8 989313 2319 62497382
Hepatitis cholestatic 16.16 11.95 54 989267 6824 62492877
Keratopathy 16.13 11.95 32 989289 584 62499117
Malabsorption 16.12 11.95 24 989297 4048 62495653
Abscess limb 16.09 11.95 131 989190 4767 62494934
Middle insomnia 16.07 11.95 123 989198 12520 62487181
Ejection fraction abnormal 16.06 11.95 4 989317 1781 62497920
Hair colour changes 16.06 11.95 15 989306 3112 62496589
Herpes zoster infection neurological 16.05 11.95 20 989301 239 62499462
Throat irritation 16.03 11.95 455 988866 37192 62462509
Molluscum contagiosum 16.01 11.95 19 989302 215 62499486
Left ventricular hypertrophy 16.01 11.95 37 989284 5278 62494423
Papulopustular rosacea 15.98 11.95 8 989313 19 62499682
West Nile viral infection 15.91 11.95 25 989296 376 62499325
Anxiety disorder 15.91 11.95 24 989297 4026 62495675
Cutaneous sporotrichosis 15.89 11.95 5 989316 0 62499701
Immunosuppressant drug level increased 15.85 11.95 20 989301 3618 62496083
Plantar fasciitis 15.84 11.95 107 989214 3668 62496033
Erythema induratum 15.82 11.95 17 989304 171 62499530
Retinal pigment epitheliopathy 15.80 11.95 20 989301 243 62499458
Dysstasia 15.79 11.95 437 988884 20729 62478972
Pruritus genital 15.79 11.95 11 989310 2643 62497058
Stress at work 15.78 11.95 48 989273 1159 62498542
Menstruation irregular 15.77 11.95 56 989265 6948 62492753
Drug eruption 15.77 11.95 571 988750 28123 62471578
Meningitis tuberculous 15.76 11.95 31 989290 562 62499139
Device infusion issue 15.76 11.95 6 989315 2032 62497669
Device issue 15.73 11.95 268 989053 23513 62476188
Self-medication 15.72 11.95 12 989309 2751 62496950
Leukodystrophy 15.71 11.95 8 989313 20 62499681
Bone marrow oedema 15.64 11.95 49 989272 1203 62498498
Product availability issue 15.63 11.95 25 989296 4096 62495605
Incorrect dose administered 15.61 11.95 769 988552 59199 62440502
Morphoea 15.61 11.95 23 989298 326 62499375
Photopsia 15.60 11.95 29 989292 4480 62495221
Anovulatory cycle 15.58 11.95 16 989305 152 62499549
Immune effector cell-associated neurotoxicity syndrome 15.57 11.95 8 989313 2269 62497432
Postoperative wound infection 15.55 11.95 248 989073 10677 62489024
International normalised ratio decreased 15.53 11.95 29 989292 4472 62495229
Orthopnoea 15.52 11.95 48 989273 6213 62493488
Tongue neoplasm 15.51 11.95 11 989310 59 62499642
Lymphoplasmacytoid lymphoma/immunocytoma 15.50 11.95 6 989315 5 62499696
Therapeutic response shortened 15.49 11.95 266 989055 11622 62488079
Anion gap increased 15.48 11.95 5 989316 1877 62497824
Haemoperitoneum 15.48 11.95 12 989309 2729 62496972
Genital herpes zoster 15.44 11.95 7 989314 12 62499689
Graft versus host disease in lung 15.41 11.95 24 989297 358 62499343
Necrotising retinitis 15.41 11.95 25 989296 387 62499314
Perineal necrosis 15.37 11.95 14 989307 113 62499588
Concomitant disease progression 15.35 11.95 7 989314 2127 62497574
Engraftment syndrome 15.29 11.95 28 989293 480 62499221
Obliterative bronchiolitis 15.29 11.95 69 989252 2026 62497675
Erythema nodosum 15.28 11.95 129 989192 4746 62494955
Sacroiliac joint dysfunction 15.25 11.95 9 989312 33 62499668
Type I hypersensitivity 15.24 11.95 14 989307 2928 62496773
Ocular toxicity 15.24 11.95 34 989287 676 62499025
Subclavian artery occlusion 15.19 11.95 8 989313 22 62499679
Central venous catheterisation 15.16 11.95 11 989310 2588 62497113
Colitis 15.15 11.95 610 988711 47918 62451783
Walking aid user 15.15 11.95 243 989078 10474 62489227
Polydipsia 15.11 11.95 20 989301 3544 62496157
Anal fistula 15.11 11.95 101 989220 3450 62496251
Injection site haematoma 15.10 11.95 168 989153 6664 62493037
Blood parathyroid hormone increased 15.10 11.95 15 989306 3023 62496678
Burning sensation 15.09 11.95 693 988628 53714 62445987
Ventricular hypokinesia 15.09 11.95 31 989290 4613 62495088
Arteriosclerosis coronary artery 15.08 11.95 73 989248 8300 62491401
Chronic graft versus host disease oral 15.06 11.95 15 989306 137 62499564
Human herpesvirus 6 infection 15.02 11.95 88 989233 2869 62496832
Metastases to reproductive organ 15.00 11.95 6 989315 6 62499695
Tendon graft 15.00 11.95 6 989315 6 62499695
Gastrointestinal sounds abnormal 14.97 11.95 25 989296 4026 62495675
Therapeutic product ineffective 14.96 11.95 61 989260 1711 62497990
Squamous cell carcinoma of the cervix 14.92 11.95 22 989299 312 62499389
Skin discolouration 14.91 11.95 462 988859 37366 62462335
Medication error 14.90 11.95 664 988657 51620 62448081
Invasive ductal breast carcinoma 14.88 11.95 170 989151 6788 62492913
Extremity contracture 14.88 11.95 49 989272 1236 62498465
Angle closure glaucoma 14.87 11.95 8 989313 2211 62497490
Ventricular hypertrophy 14.86 11.95 19 989302 3417 62496284
Colitis microscopic 14.83 11.95 216 989105 9123 62490578
Acute myeloid leukaemia 14.82 11.95 361 988960 16786 62482915
Respiratory rate decreased 14.82 11.95 20 989301 3515 62496186
Strongyloidiasis 14.82 11.95 48 989273 1200 62498501
Bone cyst 14.81 11.95 72 989249 2182 62497519
Rash morbilliform 14.78 11.95 18 989303 3307 62496394
Erythrodermic psoriasis 14.76 11.95 42 989279 976 62498725
Bile duct cancer 14.74 11.95 32 989289 624 62499077
Pertussis 14.73 11.95 33 989288 658 62499043
Bruxism 14.72 11.95 20 989301 3505 62496196
Libido decreased 14.71 11.95 12 989309 2660 62497041
Stenosis 14.70 11.95 53 989268 1401 62498300
Right ventricular dysfunction 14.67 11.95 5 989316 1814 62497887
Hidradenitis 14.65 11.95 85 989236 2761 62496940
Tendonitis 14.64 11.95 405 988916 19210 62480491
Torticollis 14.64 11.95 6 989315 1943 62497758
Device alarm issue 14.62 11.95 3 989318 1527 62498174
Follicle centre lymphoma, follicular grade I, II, III 14.59 11.95 12 989309 83 62499618
Head discomfort 14.58 11.95 136 989185 13279 62486422
Blood creatine increased 14.56 11.95 42 989279 5559 62494142
Cardiovascular disorder 14.51 11.95 116 989205 11696 62488005
Periprosthetic fracture 14.51 11.95 26 989295 438 62499263
Discouragement 14.50 11.95 48 989273 1214 62498487
Bursitis infective 14.48 11.95 50 989271 1293 62498408
Decreased immune responsiveness 14.48 11.95 128 989193 4773 62494928
BK virus infection 14.40 11.95 94 989227 3185 62496516
Chronic graft versus host disease in liver 14.38 11.95 20 989301 268 62499433
Bone marrow disorder 14.37 11.95 75 989246 2339 62497362
Product container issue 14.34 11.95 5 989316 1788 62497913
Granulomatous dermatitis 14.33 11.95 15 989306 146 62499555
Acute interstitial pneumonitis 14.31 11.95 33 989288 671 62499030
Breath sounds abnormal 14.31 11.95 106 989215 10867 62488834
Lower respiratory tract inflammation 14.27 11.95 13 989308 105 62499596
Quadrantanopia 14.25 11.95 8 989313 26 62499675
Device related thrombosis 14.23 11.95 5 989316 1780 62497921
Enzyme level increased 14.23 11.95 22 989299 326 62499375
Localised oedema 14.22 11.95 40 989281 5338 62494363
Polyarteritis nodosa 14.22 11.95 20 989301 271 62499430
Cytomegalovirus enteritis 14.22 11.95 20 989301 271 62499430
Acute lymphocytic leukaemia 14.18 11.95 77 989244 2439 62497262
Femoroacetabular impingement 14.16 11.95 7 989314 16 62499685
Intervertebral disc compression 14.15 11.95 46 989275 1152 62498549
Root canal infection 14.15 11.95 24 989297 386 62499315
Nasal congestion 14.12 11.95 858 988463 64802 62434899
Corneal oedema 14.12 11.95 3 989318 1490 62498211
Infusion site nodule 14.11 11.95 3 989318 1489 62498212
Pneumocystis jirovecii infection 14.08 11.95 53 989268 1431 62498270
Pseudomonas test positive 14.06 11.95 34 989287 714 62498987
Product administered at inappropriate site 14.05 11.95 17 989304 3132 62496569
Oesophageal squamous cell carcinoma 14.04 11.95 14 989307 128 62499573
Deafness 14.04 11.95 373 988948 17584 62482117
Blood phosphorus increased 14.01 11.95 17 989304 3128 62496573
Parakeratosis 14.00 11.95 20 989301 275 62499426
Spinal meningioma benign 13.99 11.95 13 989308 108 62499593
Device malfunction 13.93 11.95 195 989126 17662 62482039
Pulmonary thrombosis 13.92 11.95 79 989242 8623 62491078
Rash papular 13.90 11.95 167 989154 15535 62484166
Pseudomonal sepsis 13.88 11.95 74 989247 2327 62497374
Herpes simplex meningoencephalitis 13.88 11.95 7 989314 17 62499684
Coronary artery occlusion 13.85 11.95 73 989248 8118 62491583
Genital abscess 13.85 11.95 20 989301 278 62499423
Chloroma 13.85 11.95 18 989303 225 62499476
Homicidal ideation 13.81 11.95 5 989316 1747 62497954
Sinus node dysfunction 13.80 11.95 33 989288 4652 62495049
Tubular breast carcinoma 13.80 11.95 9 989312 41 62499660
Conduction disorder 13.77 11.95 3 989318 1464 62498237
Maternal exposure before pregnancy 13.76 11.95 180 989141 7423 62492278
Blood pressure abnormal 13.70 11.95 161 989160 15037 62484664
Essential hypertension 13.63 11.95 37 989284 4996 62494705
DNA antibody positive 13.63 11.95 22 989299 339 62499362
Enuresis 13.62 11.95 12 989309 2561 62497140
Vasculitic rash 13.61 11.95 50 989271 1334 62498367
Stoma site discharge 13.59 11.95 4 989317 1594 62498107
Lipodystrophy acquired 13.57 11.95 3 989318 1449 62498252
Gastroenteritis norovirus 13.54 11.95 66 989255 2002 62497699
Chest X-ray abnormal 13.54 11.95 119 989202 4430 62495271
Osteopenia 13.52 11.95 404 988917 19381 62480320
Akinesia 13.52 11.95 4 989317 1589 62498112
Conjunctivitis bacterial 13.50 11.95 21 989300 313 62499388
Infusion site discomfort 13.48 11.95 3 989318 1443 62498258
Disseminated varicella zoster virus infection 13.48 11.95 19 989302 258 62499443
Candida pneumonia 13.44 11.95 15 989306 158 62499543
Bronchial secretion retention 13.43 11.95 14 989307 2759 62496942
Diffuse alveolar damage 13.41 11.95 38 989283 881 62498820
Neck deformity 13.40 11.95 67 989254 2054 62497647
Prosthesis implantation 13.39 11.95 11 989310 76 62499625
Therapeutic response delayed 13.36 11.95 31 989290 633 62499068
Cutaneous sarcoidosis 13.36 11.95 22 989299 345 62499356
Application site vesicles 13.34 11.95 3 989318 1432 62498269
Brain oedema 13.33 11.95 149 989172 14046 62485655
Hyperammonaemic encephalopathy 13.31 11.95 11 989310 2423 62497278
Staphylococcal sepsis 13.31 11.95 189 989132 7939 62491762
Facial pain 13.30 11.95 103 989218 10458 62489243
Perirectal abscess 13.30 11.95 38 989283 885 62498816
Helicobacter gastritis 13.27 11.95 56 989265 1596 62498105
Therapy cessation 13.25 11.95 367 988954 30090 62469611
Hypocomplementaemia 13.23 11.95 16 989305 185 62499516
Scleroderma renal crisis 13.22 11.95 21 989300 319 62499382
Intermenstrual bleeding 13.20 11.95 71 989250 7855 62491846
Pustule 13.19 11.95 57 989264 1642 62498059
Hyperparathyroidism 13.18 11.95 14 989307 2735 62496966
Heart rate irregular 13.16 11.95 258 989063 22163 62477538
Vasoplegia syndrome 13.14 11.95 5 989316 1694 62498007
Eosinophil count decreased 13.13 11.95 9 989312 2181 62497520
Hiatus hernia 13.13 11.95 247 989074 21347 62478354
Loose body in joint 13.11 11.95 47 989274 1239 62498462
Diabetic eye disease 13.09 11.95 14 989307 140 62499561
Sinus disorder 13.09 11.95 287 989034 24266 62475435
General physical health deterioration 13.05 11.95 2857 986464 198545 62301156
Vagus nerve paralysis 13.01 11.95 5 989316 4 62499697
Neutrophilia 13.01 11.95 31 989290 4375 62495326
Birdshot chorioretinopathy 13.00 11.95 10 989311 62 62499639
Thrombotic thrombocytopenic purpura 12.98 11.95 25 989296 3811 62495890
Aplasia 12.98 11.95 112 989209 4147 62495554
Deafness neurosensory 12.93 11.95 124 989197 4731 62494970
Non-cardiac chest pain 12.92 11.95 52 989269 6220 62493481
Device failure 12.92 11.95 49 989272 5962 62493739
Compartment syndrome 12.90 11.95 10 989311 2274 62497427
Productive cough 12.89 11.95 830 988491 62378 62437323
Histiocytic sarcoma 12.88 11.95 10 989311 63 62499638
Genital cyst 12.87 11.95 9 989312 47 62499654
Post procedural inflammation 12.87 11.95 9 989312 47 62499654
Q fever 12.87 11.95 14 989307 143 62499558
Ovarian epithelial cancer 12.86 11.95 20 989301 298 62499403
Hyperkeratosis 12.86 11.95 147 989174 5871 62493830
Soft tissue disorder 12.81 11.95 115 989206 4307 62495394
Alanine aminotransferase increased 12.80 11.95 1418 987903 102352 62397349
Immune system disorder 12.80 11.95 220 989101 9614 62490087
Diabetes mellitus 12.80 11.95 1023 988298 54787 62444914
Hereditary motor and sensory neuropathy 12.79 11.95 12 989309 101 62499600
Gingival hypertrophy 12.79 11.95 5 989316 1666 62498035
Urine output increased 12.77 11.95 3 989318 1390 62498311
Follicular lymphoma 12.76 11.95 17 989304 218 62499483
Human bocavirus infection 12.73 11.95 23 989298 390 62499311
Mouth swelling 12.72 11.95 35 989286 4705 62494996
T-cell lymphoma stage IV 12.71 11.95 4 989317 0 62499701
Chronic villitis of unknown etiology 12.71 11.95 4 989317 0 62499701
Glycogenic acanthosis 12.71 11.95 4 989317 0 62499701
Leptotrichia infection 12.71 11.95 4 989317 0 62499701
Thymoma malignant 12.71 11.95 4 989317 0 62499701
Merkel cell polyomavirus infection 12.71 11.95 4 989317 0 62499701
Bursa injury 12.71 11.95 4 989317 0 62499701
Angioimmunoblastic T-cell lymphoma stage III 12.71 11.95 4 989317 0 62499701
Bladder papilloma 12.71 11.95 4 989317 0 62499701
Gestational trophoblastic tumour 12.71 11.95 4 989317 0 62499701
CSF myelin basic protein increased 12.71 11.95 4 989317 0 62499701
Peripheral T-cell lymphoma unspecified stage II 12.71 11.95 4 989317 0 62499701
Peripheral T-cell lymphoma unspecified stage III 12.71 11.95 4 989317 0 62499701
Oral lichen planus 12.70 11.95 31 989290 655 62499046
Slow speech 12.69 11.95 4 989317 1525 62498176
Gastric neoplasm 12.67 11.95 20 989301 302 62499399
Red blood cell sedimentation rate decreased 12.67 11.95 16 989305 194 62499507
Dislocation of vertebra 12.66 11.95 197 989124 8438 62491263
Ovarian granulosa cell tumour 12.66 11.95 6 989315 12 62499689
Intestinal fibrosis 12.65 11.95 14 989307 146 62499555
Infective exacerbation of bronchiectasis 12.63 11.95 21 989300 332 62499369
Blood potassium abnormal 12.63 11.95 13 989308 2577 62497124
Antithrombin III decreased 12.63 11.95 18 989303 247 62499454
Herpes zoster oticus 12.63 11.95 20 989301 303 62499398
Combined immunodeficiency 12.61 11.95 12 989309 103 62499598
Cushingoid 12.60 11.95 194 989127 8291 62491410
Ischaemic cardiomyopathy 12.58 11.95 12 989309 2465 62497236
Tic 12.57 11.95 4 989317 1516 62498185
Right ventricular dilatation 12.54 11.95 3 989318 1373 62498328
Bowen's disease 12.54 11.95 17 989304 222 62499479
Anticonvulsant drug level increased 12.53 11.95 4 989317 1513 62498188
Central nervous system vasculitis 12.53 11.95 38 989283 916 62498785
Respiratory rate increased 12.52 11.95 144 989177 13504 62486197
Skin mass 12.52 11.95 145 989176 5810 62493891
Gingival hyperpigmentation 12.50 11.95 5 989316 5 62499696
Gelatinous transformation of the bone marrow 12.50 11.95 5 989316 5 62499696
Breast scan 12.50 11.95 5 989316 5 62499696
Drug dose omission by device 12.48 11.95 36 989285 4765 62494936
Mucocutaneous leishmaniasis 12.46 11.95 22 989299 366 62499335
Arteriospasm coronary 12.46 11.95 27 989294 3941 62495760
Hypersensitivity vasculitis 12.46 11.95 108 989213 4004 62495697
SARS-CoV-2 test positive 12.43 11.95 74 989247 7982 62491719
Injection site hypersensitivity 12.38 11.95 65 989256 2032 62497669
Cholesteatoma 12.37 11.95 14 989307 150 62499551
Arthritis enteropathic 12.37 11.95 19 989302 280 62499421
Placental disorder 12.36 11.95 4 989317 1500 62498201
Madarosis 12.35 11.95 18 989303 3063 62496638
Intervertebral disc annular tear 12.35 11.95 6 989315 13 62499688
Feeling drunk 12.34 11.95 29 989292 4113 62495588
Hepatic infection fungal 12.34 11.95 8 989313 36 62499665
Muscle haemorrhage 12.33 11.95 19 989302 3160 62496541
Chemotherapeutic drug level increased 12.31 11.95 13 989308 128 62499573
Device related infection 12.31 11.95 274 989047 23118 62476583
Accidental overdose 12.27 11.95 273 989048 23036 62476665
Bronchiolitis obliterans syndrome 12.23 11.95 13 989308 129 62499572
Antineutrophil cytoplasmic antibody positive 12.23 11.95 29 989292 601 62499100
Cutaneous lymphoma 12.23 11.95 14 989307 152 62499549
Myeloid leukaemia 12.22 11.95 22 989299 372 62499329
Scar excision 12.18 11.95 10 989311 69 62499632
Marginal zone lymphoma 12.18 11.95 8 989313 37 62499664
Bursitis infective staphylococcal 12.18 11.95 8 989313 37 62499664
Vaginal cancer 12.17 11.95 18 989303 256 62499445
Central nervous system leukaemia 12.16 11.95 13 989308 130 62499571
Catheter site swelling 12.12 11.95 4 989317 1481 62498220
Dyshidrotic eczema 12.11 11.95 29 989292 605 62499096
Pulmonary granuloma 12.10 11.95 49 989272 1370 62498331
Chronic graft versus host disease in intestine 12.06 11.95 11 989310 89 62499612
Muscle spasticity 12.05 11.95 434 988887 21360 62478341
Premature separation of placenta 12.05 11.95 7 989314 1854 62497847
Laryngeal oedema 12.04 11.95 47 989274 5671 62494030
Myxoid liposarcoma 12.04 11.95 5 989316 6 62499695
Local reaction 12.03 11.95 31 989290 678 62499023
Eczema herpeticum 12.02 11.95 14 989307 155 62499546
Cell marker increased 12.02 11.95 18 989303 259 62499442
Food craving 11.97 11.95 5 989316 1601 62498100
Sinus arrhythmia 11.97 11.95 4 989317 1469 62498232

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 4818.51 11.21 12104 316938 444647 34183242
Drug intolerance 1514.49 11.21 2302 326740 57268 34570621
Joint swelling 1485.42 11.21 2288 326754 57602 34570287
Death 1397.99 11.21 1030 328012 397019 34230870
Rheumatoid arthritis 1328.43 11.21 1717 327325 36521 34591368
Treatment failure 1239.87 11.21 1842 327200 44855 34583034
Arthralgia 1157.94 11.21 3873 325169 166168 34461721
Synovitis 1113.18 11.21 979 328063 13087 34614802
Psoriasis 973.21 11.21 1491 327551 37321 34590568
Psoriatic arthropathy 911.55 11.21 1026 328016 18772 34609117
Musculoskeletal stiffness 889.87 11.21 1585 327457 45095 34582794
Drug abuse 794.09 11.21 32 329010 99064 34528825
Completed suicide 765.97 11.21 38 329004 98130 34529759
Therapeutic product effect incomplete 745.29 11.21 1539 327503 49002 34578887
Therapeutic product effect decreased 671.36 11.21 1187 327855 33556 34594333
Mucosal inflammation 670.91 11.21 1260 327782 37362 34590527
Arthropathy 583.92 11.21 968 328074 25939 34601950
Acute graft versus host disease 570.02 11.21 480 328562 6023 34621866
Drug hypersensitivity 550.67 11.21 1839 327203 78690 34549199
Lymphoproliferative disorder 540.11 11.21 332 328710 2427 34625462
Hypotension 534.64 11.21 787 328255 220862 34407027
Contraindicated product administered 530.83 11.21 820 328222 20661 34607228
Arthritis 490.95 11.21 979 328063 30367 34597522
Febrile neutropenia 477.85 11.21 2544 326498 134305 34493584
Dyspnoea 466.78 11.21 1897 327145 374885 34253004
Constipation 448.83 11.21 378 328664 136604 34491285
Leukoencephalopathy 443.16 11.21 346 328696 3869 34624020
Chronic graft versus host disease 442.60 11.21 351 328691 4022 34623867
Stomatitis 439.85 11.21 1126 327916 41388 34586501
Rhabdomyolysis 408.26 11.21 74 328968 68089 34559800
Pain 389.33 11.21 3270 325772 201405 34426484
Hyperkalaemia 381.30 11.21 92 328950 69297 34558592
Dizziness 363.38 11.21 965 328077 217556 34410333
Dehydration 359.63 11.21 416 328626 129553 34498336
Posterior reversible encephalopathy syndrome 356.33 11.21 454 328588 9500 34618389
C-reactive protein abnormal 351.59 11.21 422 328620 8288 34619601
Bone erosion 349.08 11.21 295 328747 3720 34624169
Fall 344.10 11.21 887 328155 201998 34425891
Drug clearance decreased 343.77 11.21 214 328828 1604 34626285
Confusional state 317.63 11.21 543 328499 143617 34484272
Acute graft versus host disease in skin 316.77 11.21 313 328729 4888 34623001
Off label use 310.06 11.21 5602 323440 413922 34213967
Pancytopenia 305.58 11.21 1730 327312 93427 34534462
Bradycardia 291.68 11.21 174 328868 75244 34552645
Graft versus host disease 284.55 11.21 420 328622 10149 34617740
Cardiac arrest 284.49 11.21 291 328751 95868 34532021
C-reactive protein increased 283.73 11.21 1134 327908 52964 34574925
Red blood cell sedimentation rate increased 283.39 11.21 389 328653 8773 34619116
Acute kidney injury 280.05 11.21 1704 327338 303284 34324605
Intentional overdose 278.11 11.21 40 329002 43634 34584255
Venoocclusive liver disease 273.64 11.21 356 328686 7610 34620279
Somnolence 266.92 11.21 395 328647 110721 34517168
Syncope 263.50 11.21 283 328759 91168 34536721
Osteoarthritis 260.98 11.21 591 328451 20051 34607838
Pneumocystis jirovecii pneumonia 258.92 11.21 573 328469 19137 34608752
Pain in extremity 258.22 11.21 2055 326987 124458 34503431
Apparent death 257.40 11.21 238 328804 3406 34624483
Cardiac failure congestive 256.67 11.21 243 328799 83027 34544862
Product use in unapproved indication 252.73 11.21 1932 327110 115567 34512322
Hyponatraemia 250.59 11.21 245 328797 82446 34545443
Pulmonary fibrosis 244.13 11.21 537 328505 17859 34610030
Ankylosing spondylitis 240.22 11.21 280 328762 5324 34622565
International normalised ratio increased 238.85 11.21 74 328968 47253 34580636
Hypoglycaemia 236.45 11.21 109 328933 54531 34573358
Atrial fibrillation 236.20 11.21 499 328543 121894 34505995
Plasma cell myeloma 234.31 11.21 54 328988 41983 34585906
Liver function test increased 234.10 11.21 460 328582 14105 34613784
Mobility decreased 233.79 11.21 719 328323 29409 34598480
Diarrhoea 233.10 11.21 2448 326594 387464 34240425
Inflammation 231.54 11.21 688 328354 27607 34600282
Decreased appetite 230.34 11.21 799 328243 165593 34462296
Anaemia 227.59 11.21 1278 327764 232057 34395832
Electrocardiogram QT prolonged 227.48 11.21 53 328989 40899 34586990
Tuberculosis 226.81 11.21 338 328704 8239 34619650
Hospitalisation 226.08 11.21 127 328915 56775 34571114
Febrile bone marrow aplasia 225.01 11.21 329 328713 7880 34620009
Overdose 222.28 11.21 320 328722 90739 34537150
Malignant neoplasm progression 217.30 11.21 307 328735 87739 34540150
Asthenia 216.70 11.21 1386 327656 243865 34384024
Hand deformity 215.48 11.21 218 328824 3507 34624382
Epstein-Barr virus infection 212.40 11.21 308 328734 7320 34620569
Red blood cell sedimentation rate abnormal 211.20 11.21 212 328830 3377 34624512
Myelopathy 209.99 11.21 180 328862 2317 34625572
Drug interaction 209.90 11.21 1257 327785 224689 34403200
Hallucination 207.40 11.21 113 328929 51385 34576504
Blood glucose increased 204.06 11.21 196 328846 66522 34561367
Joint stiffness 202.84 11.21 366 328676 10507 34617382
Aggression 201.94 11.21 58 328984 38906 34588983
Epstein-Barr virus associated lymphoproliferative disorder 201.66 11.21 159 328883 1805 34626084
Agitation 197.02 11.21 151 328891 57248 34570641
Hypofibrinogenaemia 193.90 11.21 146 328896 1540 34626349
Fatigue 192.45 11.21 2401 326641 368252 34259637
Bone marrow failure 191.67 11.21 659 328383 28594 34599295
Cardio-respiratory arrest 191.51 11.21 144 328898 55129 34572760
Rheumatoid nodule 190.03 11.21 183 328859 2764 34625125
Gastrointestinal haemorrhage 188.59 11.21 340 328702 88137 34539752
Haemoglobin decreased 177.98 11.21 564 328478 120208 34507681
Loss of consciousness 176.79 11.21 317 328725 82350 34545539
Lymphoma 174.98 11.21 373 328669 12134 34615755
Graft versus host disease in gastrointestinal tract 174.79 11.21 194 328848 3489 34624400
Loss of personal independence in daily activities 173.48 11.21 695 328347 32484 34595405
Diffuse large B-cell lymphoma 173.19 11.21 275 328767 7095 34620794
Angiocentric lymphoma 171.23 11.21 74 328968 223 34627666
Mouth ulceration 171.03 11.21 359 328683 11551 34616338
Neurotoxicity 170.84 11.21 462 328580 17548 34610341
Sedation 170.81 11.21 6 329036 21000 34606889
Basal cell carcinoma 169.45 11.21 487 328555 19171 34608718
Nodule 167.96 11.21 260 328782 6559 34621330
Suicide attempt 166.19 11.21 80 328962 39036 34588853
Blood creatine phosphokinase increased 165.77 11.21 109 328933 44748 34583141
Knee arthroplasty 165.70 11.21 271 328771 7173 34620716
Gastrointestinal disorder 159.37 11.21 688 328354 33260 34594629
Diverticulitis 157.60 11.21 480 328562 19524 34608365
Grip strength decreased 157.46 11.21 171 328871 2998 34624891
Haematotoxicity 156.91 11.21 279 328763 7915 34619974
Joint effusion 156.86 11.21 218 328824 4975 34622914
Infection 153.84 11.21 1417 327625 89498 34538391
Graft versus host disease in skin 153.23 11.21 187 328855 3738 34624151
Dactylitis 150.68 11.21 99 328943 823 34627066
Anxiety 150.23 11.21 459 328583 98969 34528920
Condition aggravated 150.12 11.21 2592 326450 189604 34438285
Neuroleptic malignant syndrome 149.88 11.21 4 329038 17930 34609959
Metabolic acidosis 149.77 11.21 115 328927 43565 34584324
Suicidal ideation 148.08 11.21 99 328943 40289 34587600
Coma 142.22 11.21 132 328910 45546 34582343
Pulmonary tuberculosis 141.25 11.21 198 328844 4556 34623333
Joint range of motion decreased 140.06 11.21 249 328793 7063 34620826
Polyarthritis 139.25 11.21 192 328850 4348 34623541
Product dose omission issue 139.21 11.21 616 328426 119095 34508794
Drug reaction with eosinophilia and systemic symptoms 137.99 11.21 69 328973 32943 34594946
Arthritis bacterial 136.13 11.21 202 328840 4904 34622985
Pneumonia aspiration 135.36 11.21 117 328925 41786 34586103
Foetal exposure during pregnancy 134.90 11.21 97 328945 38004 34589885
Uveitis 134.67 11.21 249 328793 7286 34620603
Blood creatinine increased 133.34 11.21 453 328589 94523 34533366
Inappropriate schedule of product administration 131.88 11.21 1021 328021 61275 34566614
Hypokalaemia 131.05 11.21 216 328826 57998 34569891
Foot deformity 130.42 11.21 186 328856 4351 34623538
Cystitis haemorrhagic 128.10 11.21 208 328834 5471 34622418
Skin plaque 128.01 11.21 186 328856 4428 34623461
Epstein Barr virus positive mucocutaneous ulcer 127.56 11.21 65 328977 312 34627577
Acute graft versus host disease in intestine 127.40 11.21 142 328900 2566 34625323
Acute lymphocytic leukaemia recurrent 126.98 11.21 150 328892 2894 34624995
Disability 124.87 11.21 187 328855 4578 34623311
Histoplasmosis disseminated 124.39 11.21 103 328939 1260 34626629
Hepatic enzyme increased 123.60 11.21 708 328334 38372 34589517
Rheumatoid factor positive 123.53 11.21 79 328963 624 34627265
Enthesopathy 122.27 11.21 182 328860 4431 34623458
Haemophagocytic lymphohistiocytosis 121.25 11.21 331 328711 12642 34615247
Lactic acidosis 118.63 11.21 92 328950 34680 34593209
Intentional product misuse 118.58 11.21 153 328889 45458 34582431
Impaired work ability 116.39 11.21 223 328819 6707 34621182
Therapeutic response decreased 115.99 11.21 565 328477 28748 34599141
Herpes zoster 115.28 11.21 633 328409 33766 34594123
Tremor 111.81 11.21 400 328642 82187 34545702
Tenosynovitis 110.81 11.21 173 328869 4397 34623492
Abnormal behaviour 109.25 11.21 49 328993 24920 34602969
Delirium 108.85 11.21 153 328889 43838 34584051
Cerebrovascular accident 108.79 11.21 420 328622 84391 34543498
Synovial cyst 108.71 11.21 122 328920 2222 34625667
Orthostatic hypotension 108.59 11.21 54 328988 25865 34602024
Sarcoidosis 108.56 11.21 135 328907 2753 34625136
Immunosuppression 108.52 11.21 205 328837 6099 34621790
Respiratory arrest 107.93 11.21 65 328977 27978 34599911
Respiratory depression 107.90 11.21 13 329029 16232 34611657
Cardiogenic shock 107.74 11.21 58 328984 26560 34601329
Chest pain 107.32 11.21 725 328317 126037 34501852
Drug ineffective for unapproved indication 107.01 11.21 475 328567 23240 34604649
Depressed level of consciousness 107.00 11.21 148 328894 42693 34585196
Cutaneous leishmaniasis 106.01 11.21 48 328994 167 34627722
Visceral leishmaniasis 105.62 11.21 68 328974 544 34627345
Mucocutaneous ulceration 105.37 11.21 48 328994 170 34627719
Hepatotoxicity 104.35 11.21 440 328602 21045 34606844
Product use issue 104.21 11.21 980 328062 62236 34565653
Serotonin syndrome 102.67 11.21 30 329012 19903 34607986
Drug withdrawal syndrome 101.88 11.21 30 329012 19804 34608085
Cardiac failure 100.41 11.21 479 328563 90769 34537120
Sopor 100.33 11.21 3 329039 12133 34615756
Chondropathy 98.46 11.21 78 328964 892 34626997
Skin ulcer 98.00 11.21 442 328600 21774 34606115
Psychotic disorder 96.48 11.21 55 328987 24397 34603492
Epidermal necrosis 95.89 11.21 59 328983 432 34627457
Restlessness 95.39 11.21 61 328981 25421 34602468
Platelet count decreased 95.30 11.21 697 328345 119020 34508869
Sleep disorder due to general medical condition, insomnia type 94.98 11.21 87 328955 1229 34626660
Tuberculin test positive 93.83 11.21 82 328960 1085 34626804
Vomiting 93.65 11.21 1704 327338 245917 34381972
Swelling 93.35 11.21 701 328341 41665 34586224
Blood pressure fluctuation 92.36 11.21 476 328566 24773 34603116
Oedema peripheral 91.83 11.21 705 328337 119107 34508782
Multiple sclerosis relapse 91.06 11.21 9 329033 13124 34614765
Sacroiliitis 90.93 11.21 90 328952 1408 34626481
Anti-cyclic citrullinated peptide antibody positive 90.78 11.21 99 328943 1744 34626145
Nasopharyngitis 90.78 11.21 1033 328009 68935 34558954
Epstein-Barr virus infection reactivation 89.62 11.21 78 328964 1026 34626863
Hypomagnesaemia 89.34 11.21 47 328995 21804 34606085
Acute myocardial infarction 89.16 11.21 237 328805 53482 34574407
Urinary retention 88.99 11.21 127 328915 36161 34591728
Chronic kidney disease 88.98 11.21 157 328885 41053 34586836
Myocardial infarction 87.03 11.21 725 328317 120360 34507529
General physical health deterioration 86.42 11.21 781 328261 127488 34500401
Squamous cell carcinoma 86.34 11.21 271 328771 11204 34616685
Drug specific antibody present 86.20 11.21 129 328913 3156 34624733
Intentional product use issue 85.36 11.21 900 328142 58916 34568973
Angioedema 84.72 11.21 138 328904 37236 34590653
Musculoskeletal discomfort 84.71 11.21 215 328827 7853 34620036
Venoocclusive disease 84.57 11.21 119 328923 2748 34625141
Intentional self-injury 84.49 11.21 14 329028 13757 34614132
Hypocalcaemia 84.46 11.21 63 328979 24226 34603663
Rheumatoid factor negative 84.27 11.21 69 328973 830 34627059
Extrapyramidal disorder 83.86 11.21 11 329031 12869 34615020
Peripheral swelling 83.64 11.21 1094 327948 75447 34552442
Blood urea increased 82.97 11.21 98 328944 30266 34597623
Cytomegalovirus infection reactivation 82.66 11.21 162 328880 4956 34622933
Hyperglycaemia 82.03 11.21 154 328888 39326 34588563
Melaena 81.74 11.21 129 328913 35251 34592638
Skin lesion 80.32 11.21 414 328628 21547 34606342
Spermatozoa abnormal 79.81 11.21 27 329015 29 34627860
Toxicity to various agents 79.77 11.21 1366 327676 198996 34428893
Delusion 79.42 11.21 12 329030 12623 34615266
Hallucination, visual 79.28 11.21 34 329008 17757 34610132
Malignant melanoma 79.20 11.21 210 328832 7880 34620009
Cytomegalovirus infection 78.42 11.21 467 328575 25668 34602221
Tachycardia 78.28 11.21 472 328570 84300 34543589
Diabetic ketoacidosis 77.93 11.21 36 329006 17996 34609893
Chronic graft versus host disease in skin 77.43 11.21 68 328974 906 34626983
Unevaluable event 77.04 11.21 117 328925 32473 34595416
Abdominal distension 76.05 11.21 288 328754 58204 34569685
Oxidative stress 75.46 11.21 27 329015 39 34627850
Abscess 75.45 11.21 264 328778 11553 34616336
Pulmonary mass 74.81 11.21 278 328764 12534 34615355
Finger deformity 74.05 11.21 81 328961 1432 34626457
Coronary artery disease 73.61 11.21 222 328820 48083 34579806
Foetal methotrexate syndrome 73.50 11.21 20 329022 0 34627889
Mycobacterium tuberculosis complex test positive 73.50 11.21 76 328966 1256 34626633
Myelosuppression 73.13 11.21 367 328675 18898 34608991
Full blood count decreased 72.35 11.21 40 329002 18048 34609841
Chemotherapeutic drug level increased 72.06 11.21 37 329005 181 34627708
Disseminated tuberculosis 71.79 11.21 96 328946 2109 34625780
Wheezing 71.51 11.21 179 328863 41223 34586666
Hip arthroplasty 71.40 11.21 141 328901 4338 34623551
Hepatic steatosis 71.26 11.21 352 328690 18010 34609879
Faecal calprotectin increased 71.23 11.21 103 328939 2441 34625448
Injection site pain 71.05 11.21 618 328424 38387 34589502
Dry mouth 70.63 11.21 109 328933 30056 34597833
Miosis 70.32 11.21 5 329037 9530 34618359
Myalgia 70.17 11.21 483 328559 83627 34544262
X-ray abnormal 69.86 11.21 48 328994 433 34627456
Dysgeusia 69.78 11.21 88 328954 26409 34601480
Musculoskeletal pain 69.35 11.21 527 328515 31436 34596453
Disorientation 69.35 11.21 129 328913 33059 34594830
Pulmonary toxicity 68.96 11.21 168 328874 5979 34621910
Latent tuberculosis 68.51 11.21 74 328968 1289 34626600
Cytomegalovirus chorioretinitis 68.45 11.21 122 328920 3467 34624422
Ventricular fibrillation 68.33 11.21 69 328973 22885 34605004
Urinary tract infection 68.10 11.21 487 328555 83594 34544295
Sinus bradycardia 67.70 11.21 19 329023 12944 34614945
Insomnia 67.66 11.21 638 328404 103269 34524620
Product quality issue 67.66 11.21 38 329004 16997 34610892
Aphthous ulcer 67.60 11.21 147 328895 4848 34623041
Myoclonus 67.46 11.21 27 329015 14698 34613191
Thrombotic microangiopathy 67.45 11.21 237 328805 10393 34617496
Bone cyst 67.00 11.21 79 328963 1521 34626368
Dislocation of vertebra 66.78 11.21 45 328997 392 34627497
Atlantoaxial instability 66.21 11.21 41 329001 304 34627585
Sensitivity to weather change 65.97 11.21 79 328963 1547 34626342
Balance disorder 65.47 11.21 182 328860 40472 34587417
Haematuria 65.42 11.21 246 328796 49820 34578069
Histoplasmosis 65.31 11.21 76 328966 1442 34626447
Ventricular tachycardia 65.19 11.21 93 328949 26486 34601403
Demyelination 64.68 11.21 112 328930 3109 34624780
Paranoia 64.32 11.21 17 329025 12051 34615838
Injury 64.12 11.21 60 328982 20627 34607262
Spinal instability 64.09 11.21 41 329001 324 34627565
Cognitive disorder 64.05 11.21 107 328935 28586 34599303
Haematemesis 64.05 11.21 101 328941 27610 34600279
Haematocrit decreased 64.03 11.21 129 328913 32087 34595802
Limb discomfort 63.92 11.21 239 328803 10808 34617081
Blood potassium increased 63.80 11.21 38 329004 16457 34611432
Dyskinesia 63.77 11.21 70 328972 22343 34605546
Wrist deformity 63.68 11.21 41 329001 328 34627561
Bladder transitional cell carcinoma 63.67 11.21 100 328942 2555 34625334
Adenovirus infection 63.64 11.21 148 328894 5109 34622780
Haemorrhage 63.55 11.21 258 328784 51112 34576777
Mineral metabolism disorder 63.38 11.21 41 329001 331 34627558
Disease recurrence 63.19 11.21 382 328660 21108 34606781
Bursitis 63.19 11.21 151 328891 5307 34622582
Leukaemia recurrent 63.13 11.21 77 328965 1538 34626351
Cardiac disorder 63.02 11.21 202 328840 42924 34584965
Atrial flutter 62.93 11.21 34 329008 15540 34612349
Fibromyalgia 62.52 11.21 108 328934 2992 34624897
Seronegative arthritis 62.29 11.21 62 328980 977 34626912
Aplasia 62.07 11.21 135 328907 4453 34623436
Hyperhidrosis 61.98 11.21 437 328605 75255 34552634
Angioimmunoblastic T-cell lymphoma 61.82 11.21 39 329003 300 34627589
Depression 61.60 11.21 600 328442 96498 34531391
Vein rupture 61.29 11.21 58 328984 856 34627033
Blood pressure decreased 61.07 11.21 263 328779 51252 34576637
Fear of injection 60.68 11.21 74 328968 1478 34626411
Pleurisy 60.58 11.21 136 328906 4585 34623304
Renal impairment 60.39 11.21 583 328459 93930 34533959
Complications of bone marrow transplant 60.32 11.21 34 329008 207 34627682
Nightmare 60.25 11.21 30 329012 14361 34613528
Anal fistula 59.97 11.21 147 328895 5252 34622637
Joint ankylosis 59.92 11.21 74 328968 1498 34626391
Cytogenetic abnormality 58.50 11.21 56 328986 839 34627050
Inflammatory bowel disease 57.94 11.21 101 328941 2819 34625070
Akathisia 57.71 11.21 5 329037 8104 34619785
Rash maculo-papular 57.34 11.21 113 328929 28338 34599551
Wrong technique in product usage process 57.28 11.21 162 328880 35824 34592065
Therapy partial responder 57.27 11.21 210 328832 9406 34618483
Hepatic fibrosis 57.20 11.21 131 328911 4476 34623413
Joint destruction 57.20 11.21 39 329003 347 34627542
Unresponsive to stimuli 56.86 11.21 108 328934 27461 34600428
Squamous cell carcinoma of lung 56.80 11.21 80 328962 1849 34626040
Spondyloarthropathy 56.68 11.21 48 328994 607 34627282
Dystonia 56.44 11.21 16 329026 10829 34617060
Haemoptysis 56.16 11.21 157 328885 34849 34593040
Clinodactyly 55.65 11.21 33 329009 224 34627665
Stevens-Johnson syndrome 55.52 11.21 56 328986 18583 34609306
Engraftment syndrome 55.22 11.21 57 328985 940 34626949
Neuropathy peripheral 55.15 11.21 509 328533 82754 34545135
Kidney transplant rejection 55.09 11.21 4 329038 7493 34620396
Skin erosion 54.88 11.21 82 328960 2003 34625886
Lung neoplasm malignant 54.88 11.21 315 328727 17080 34610809
Blood glucose decreased 54.81 11.21 28 329014 13209 34614680
Medial tibial stress syndrome 54.54 11.21 19 329023 24 34627865
Blood potassium decreased 54.31 11.21 53 328989 17862 34610027
Abscess limb 54.01 11.21 109 328933 3408 34624481
Frequent bowel movements 53.86 11.21 251 328791 12536 34615353
Acute graft versus host disease in liver 53.80 11.21 70 328972 1496 34626393
Troponin increased 53.63 11.21 20 329022 11369 34616520
Hepatic cirrhosis 53.63 11.21 312 328730 17002 34610887
Pulmonary hypertension 53.54 11.21 71 328971 20853 34607036
Poisoning 53.47 11.21 24 329018 12202 34615687
Fluid retention 53.14 11.21 108 328934 26779 34601110
Hospice care 53.09 11.21 3 329039 6937 34620952
Therapy non-responder 53.04 11.21 583 328459 38563 34589326
Liver disorder 52.59 11.21 508 328534 32489 34595400
Pneumonia legionella 52.56 11.21 76 328966 1801 34626088
Viral haemorrhagic cystitis 52.32 11.21 60 328982 1120 34626769
Flushing 52.31 11.21 145 328897 32275 34595614
Arrhythmia 52.12 11.21 168 328874 35640 34592249
Pulmonary oedema 51.95 11.21 250 328792 47279 34580610
Palpitations 51.89 11.21 197 328845 39789 34588100
Lymphadenopathy 51.85 11.21 451 328591 28012 34599877
Irritability 51.55 11.21 96 328946 24594 34603295
Graft versus host disease in liver 51.47 11.21 62 328980 1222 34626667
Acne cystic 51.46 11.21 41 329001 473 34627416
Hepatic enzyme abnormal 51.44 11.21 93 328949 2673 34625216
White blood cell count increased 51.32 11.21 206 328836 40945 34586944
Seizure 51.21 11.21 687 328355 104170 34523719
Superior sagittal sinus thrombosis 51.17 11.21 32 329010 242 34627647
Immunodeficiency 51.09 11.21 140 328902 5358 34622531
Ileal stenosis 51.02 11.21 64 328978 1317 34626572
Upper gastrointestinal haemorrhage 50.86 11.21 102 328940 25416 34602473
Rheumatoid lung 50.63 11.21 53 328989 889 34627000
Onychoclasis 50.41 11.21 75 328967 1825 34626064
Transient ischaemic attack 50.36 11.21 116 328926 27497 34600392
Poisoning deliberate 50.35 11.21 7 329035 7837 34620052
Muscle rigidity 50.33 11.21 18 329024 10500 34617389
Hepatic encephalopathy 49.89 11.21 39 329003 14646 34613243
Erectile dysfunction 49.83 11.21 73 328969 20564 34607325
Disturbance in attention 49.78 11.21 106 328936 25839 34602050
B-cell lymphoma 49.75 11.21 120 328922 4243 34623646
Mycobacterial infection 49.58 11.21 84 328958 2290 34625599
Joint arthroplasty 49.45 11.21 51 328991 840 34627049
Blood sodium decreased 49.35 11.21 48 328994 16203 34611686
Alanine aminotransferase abnormal 49.29 11.21 125 328917 4563 34623326
Oral mucosa erosion 49.25 11.21 53 328989 919 34626970
Osteonecrosis 49.20 11.21 273 328769 14617 34613272
Oedema 49.18 11.21 242 328800 45499 34582390
Ill-defined disorder 48.64 11.21 259 328783 13650 34614239
Cutaneous T-cell lymphoma 48.61 11.21 66 328976 1472 34626417
Interstitial lung disease 48.49 11.21 874 328168 64408 34563481
Vision blurred 48.38 11.21 245 328797 45718 34582171
Intestinal polyp 48.26 11.21 54 328988 980 34626909
Hypertriglyceridaemia 48.23 11.21 182 328860 8266 34619623
Anhedonia 48.15 11.21 7 329035 7578 34620311
Amnesia 48.12 11.21 112 328930 26451 34601438
Tenderness 47.86 11.21 159 328883 6775 34621114
Arthritis infective 47.85 11.21 102 328940 3317 34624572
Colitis ulcerative 47.52 11.21 292 328750 16228 34611661
Skin cancer 47.01 11.21 207 328835 10090 34617799
Fear 46.71 11.21 20 329022 10456 34617433
Memory impairment 46.68 11.21 229 328813 43089 34584800
Lymph node tuberculosis 46.36 11.21 37 329005 428 34627461
Juvenile idiopathic arthritis 46.25 11.21 72 328970 1825 34626064
End stage renal disease 46.25 11.21 13 329029 8848 34619041
Injection site haemorrhage 45.84 11.21 198 328844 9570 34618319
Subdural haematoma 45.72 11.21 76 328966 20345 34607544
Intervertebral disc space narrowing 45.69 11.21 53 328989 1002 34626887
Hypoxia 45.62 11.21 317 328725 54778 34573111
Labelled drug-drug interaction medication error 45.51 11.21 44 328998 14895 34612994
Mental status changes 45.40 11.21 194 328848 37889 34590000
Clear cell renal cell carcinoma 45.35 11.21 55 328987 1092 34626797
Hallucination, auditory 45.32 11.21 28 329014 11889 34616000
Premature baby 44.95 11.21 72 328970 19561 34608328
Hypophosphataemia 44.65 11.21 24 329018 11002 34616887
Aspiration 44.54 11.21 30 329012 12164 34615725
Cerebral haemorrhage 44.13 11.21 174 328868 34763 34593126
Hypovolaemia 43.85 11.21 16 329026 9218 34618671
Rash 43.84 11.21 1684 327358 221068 34406821
Dysphagia 43.65 11.21 376 328666 62005 34565884
Erythrodermic psoriasis 43.42 11.21 48 328994 859 34627030
Red blood cell count decreased 43.38 11.21 135 328907 28955 34598934
Haematoma 43.21 11.21 112 328930 25493 34602396
Peritonitis bacterial 42.85 11.21 4 329038 6106 34621783
Blood phosphorus increased 42.85 11.21 10 329032 7711 34620178
Therapeutic response shortened 42.68 11.21 160 328882 7244 34620645
Chronic graft versus host disease in liver 42.54 11.21 35 329007 424 34627465
Chronic graft versus host disease in intestine 42.40 11.21 28 329014 235 34627654
Ureaplasma infection 42.38 11.21 32 329010 339 34627550
Angina pectoris 42.34 11.21 152 328890 31211 34596678
Arachnoiditis 42.15 11.21 32 329010 342 34627547
Minimal residual disease 41.93 11.21 34 329008 403 34627486
Lupus-like syndrome 41.83 11.21 85 328957 2671 34625218
Eosinophilia 41.77 11.21 118 328924 26104 34601785
Photosensitivity reaction 41.75 11.21 204 328838 10390 34617499
Device occlusion 41.64 11.21 6 329036 6539 34621350
Scleroderma 41.63 11.21 62 328980 1510 34626379
Disease progression 41.59 11.21 741 328301 107336 34520553
Incorrect disposal of product 41.55 11.21 31 329011 322 34627567
Hypersensitivity 41.48 11.21 806 328236 60229 34567660
Cerebral venous sinus thrombosis 41.47 11.21 37 329005 504 34627385
Drug eruption 41.44 11.21 325 328717 19573 34608316
Metastatic bronchial carcinoma 41.31 11.21 30 329012 298 34627591
Hiccups 40.75 11.21 22 329020 10060 34617829
Osteopenia 40.69 11.21 119 328923 4730 34623159
Head injury 40.27 11.21 68 328974 18092 34609797
Lung disorder 40.02 11.21 501 328541 34195 34593694
Hyperthyroidism 39.94 11.21 25 329017 10541 34617348
Progressive multifocal leukoencephalopathy 39.91 11.21 190 328852 9574 34618315
Subdural hygroma 39.56 11.21 30 329012 320 34627569
Mania 39.56 11.21 20 329022 9491 34618398
Blood calcium decreased 39.32 11.21 23 329019 10061 34617828
Joint lock 39.22 11.21 54 328988 1221 34626668
Oral herpes 39 11.21 128 328914 5419 34622470
Drug tolerance decreased 38.98 11.21 68 328974 1899 34625990
Pneumonia fungal 38.92 11.21 151 328891 6949 34620940
Osteonecrosis of jaw 38.74 11.21 68 328974 17821 34610068
Soft tissue swelling 38.66 11.21 36 329006 520 34627369
Peritoneal tuberculosis 38.16 11.21 30 329012 339 34627550
Glioma 38.16 11.21 30 329012 339 34627550
Localised infection 38.16 11.21 290 328752 17297 34610592
Lymphocyte count decreased 38.13 11.21 99 328943 22523 34605366
Inflammatory marker increased 38.06 11.21 119 328923 4909 34622980
Dyspnoea exertional 37.84 11.21 245 328797 43034 34584855
Depressed mood 37.83 11.21 78 328964 19239 34608650
Salivary hypersecretion 37.75 11.21 17 329025 8627 34619262
Full blood count abnormal 37.74 11.21 74 328968 18594 34609295
Heart rate increased 37.70 11.21 268 328774 46075 34581814
Electrocardiogram abnormal 37.63 11.21 20 329022 9227 34618662
Facial paralysis 37.62 11.21 200 328842 10534 34617355
Withdrawal syndrome 37.58 11.21 37 329005 12418 34615471
Faeces discoloured 37.54 11.21 51 328991 14827 34613062
Cytomegalovirus viraemia 37.51 11.21 154 328888 7276 34620613
Molluscum contagiosum 37.44 11.21 27 329015 265 34627624
No adverse event 37.39 11.21 102 328940 22825 34605064
Presyncope 37.29 11.21 77 328965 18982 34608907
Injection site bruising 37.19 11.21 171 328871 8492 34619397
Mass 36.92 11.21 160 328882 7745 34620144
Treatment noncompliance 36.74 11.21 138 328904 27962 34599927
Hypervolaemia 36.59 11.21 82 328960 19627 34608262
Syringe issue 36.48 11.21 5 329037 5659 34622230
Jaundice 36.43 11.21 165 328877 31717 34596172
Chromaturia 36.41 11.21 50 328992 14470 34613419
Spinal pain 36.25 11.21 130 328912 5759 34622130
White blood cell count decreased 36.21 11.21 656 328386 94789 34533100
Cytotoxic oedema 35.99 11.21 22 329020 159 34627730
Cytology abnormal 35.96 11.21 30 329012 371 34627518
Non-Hodgkin's lymphoma 35.96 11.21 57 328985 1468 34626421
Hypothermia 35.94 11.21 29 329013 10719 34617170
Supraventricular tachycardia 35.94 11.21 31 329011 11086 34616803
Failure to thrive 35.90 11.21 18 329024 8583 34619306
Myelodysplastic syndrome 35.84 11.21 306 328736 18902 34608987
Central nervous system leukaemia 35.66 11.21 26 329016 260 34627629
Acute myeloid leukaemia 35.65 11.21 294 328748 17976 34609913
Gastrointestinal toxicity 35.64 11.21 79 328963 2640 34625249
Device leakage 35.54 11.21 9 329033 6566 34621323
Varicella zoster virus infection 35.23 11.21 62 328980 1744 34626145
Post transplant lymphoproliferative disorder 35.11 11.21 138 328904 6390 34621499
Hidradenitis 35.06 11.21 47 328995 1035 34626854
Hyperbilirubinaemia 35.02 11.21 275 328767 16568 34611321
Episcleritis 35.00 11.21 22 329020 168 34627721
Decreased immune responsiveness 34.91 11.21 59 328983 1605 34626284
Staphylococcal sepsis 34.90 11.21 184 328858 9660 34618229
Psychomotor hyperactivity 34.70 11.21 24 329018 9598 34618291
Injection site swelling 34.59 11.21 206 328836 11321 34616568
Oral disorder 34.44 11.21 103 328939 4146 34623743
Tooth fracture 34.41 11.21 94 328948 3591 34624298
Lung cancer metastatic 34.33 11.21 79 328963 2708 34625181
Rheumatoid factor increased 34.25 11.21 34 329008 534 34627355
Arthrodesis 34.24 11.21 31 329011 431 34627458
Brain natriuretic peptide increased 34.17 11.21 6 329036 5653 34622236
Fungal infection 34.14 11.21 262 328780 15673 34612216
Obliterative bronchiolitis 34.02 11.21 50 328992 1203 34626686
Thinking abnormal 33.95 11.21 8 329034 6129 34621760
Shock haemorrhagic 33.94 11.21 34 329008 11320 34616569
Pulmonary thrombosis 33.89 11.21 149 328893 7258 34620631
Dysuria 33.80 11.21 136 328906 27016 34600873
Leukoerythroblastosis 33.70 11.21 14 329028 37 34627852
Speech disorder 33.68 11.21 126 328916 25560 34602329
Pneumonia cryptococcal 33.57 11.21 42 329000 862 34627027
Abdominal discomfort 33.46 11.21 768 328274 59067 34568822
Obsessive-compulsive disorder 33.38 11.21 6 329036 5558 34622331
Craniosynostosis 33.19 11.21 28 329014 352 34627537
Prostate cancer 33.12 11.21 541 328501 39108 34588781
Bone marrow oedema 32.93 11.21 36 329006 636 34627253
Contraindication to medical treatment 32.92 11.21 37 329005 675 34627214
Right ventricular failure 32.91 11.21 21 329021 8763 34619126
Bronchial carcinoma 32.89 11.21 44 328998 967 34626922
Engraft failure 32.84 11.21 31 329011 456 34627433
Impaired healing 32.79 11.21 252 328790 15082 34612807
Blood stem cell transplant failure 32.62 11.21 29 329013 393 34627496
Synovial disorder 32.61 11.21 22 329020 192 34627697
Exposure during pregnancy 32.60 11.21 22 329020 8912 34618977
Bursitis infective 32.54 11.21 34 329008 569 34627320
Intervertebral discitis 32.49 11.21 67 328975 2128 34625761
Bundle branch block right 32.49 11.21 15 329027 7501 34620388
Complications of transplanted kidney 32.37 11.21 3 329039 4606 34623283
Lip swelling 32.28 11.21 64 328978 16016 34611873
Leukocytosis 32.24 11.21 117 328925 23948 34603941
Oropharyngeal pain 32.22 11.21 491 328551 34994 34592895
Altered state of consciousness 32.22 11.21 109 328933 22784 34605105
Swollen tongue 32.10 11.21 55 328987 14550 34613339
Meningitis listeria 32.04 11.21 31 329011 471 34627418
Ascites 32.00 11.21 282 328760 46289 34581600
Gingivitis ulcerative 31.97 11.21 14 329028 44 34627845
Bronchopulmonary aspergillosis 31.96 11.21 242 328800 14417 34613472
Lethargy 31.92 11.21 241 328801 40881 34587008
Blood fibrinogen decreased 31.84 11.21 48 328994 1182 34626707
Abdominal pain upper 31.84 11.21 477 328565 71013 34556876
Acute myeloid leukaemia recurrent 31.84 11.21 66 328976 2104 34625785
Aspergillus infection 31.79 11.21 211 328831 12043 34615846
Pollakiuria 31.73 11.21 88 328954 19586 34608303
Pericarditis 31.73 11.21 203 328839 11442 34616447
Food intolerance 31.63 11.21 52 328990 1382 34626507
Blood pressure systolic increased 31.62 11.21 343 328699 22609 34605280
Anaphylactic shock 31.53 11.21 64 328978 15877 34612012
Pustular psoriasis 31.48 11.21 56 328986 1589 34626300
Acidosis 31.34 11.21 34 329008 10911 34616978
Cerebral venous thrombosis 31.19 11.21 37 329005 717 34627172
Tardive dyskinesia 31.15 11.21 8 329034 5782 34622107
Bronchospasm 31.10 11.21 33 329009 10698 34617191
Palmar-plantar erythrodysaesthesia syndrome 31.07 11.21 70 328972 16725 34611164
Nail psoriasis 31.05 11.21 16 329026 79 34627810
Axial spondyloarthritis 30.88 11.21 26 329016 326 34627563
Priapism 30.81 11.21 5 329037 4989 34622900
Lipoma 30.79 11.21 57 328985 1669 34626220
Transaminases increased 30.79 11.21 387 328655 26436 34601453
Rheumatic disorder 30.72 11.21 33 329009 571 34627318
Pruritus 30.68 11.21 1061 327981 140920 34486969
Mucormycosis 30.66 11.21 124 328918 5818 34622071
Muscle twitching 30.60 11.21 31 329011 10267 34617622
Vertigo 30.48 11.21 130 328912 25406 34602483
Chest discomfort 30.47 11.21 347 328695 54183 34573706
Pyoderma gangrenosum 30.37 11.21 51 328991 1380 34626509
Tubulointerstitial nephritis 30.34 11.21 99 328943 20925 34606964
Tonsil cancer 30.30 11.21 45 328997 1093 34626796
Ankle deformity 30.25 11.21 22 329020 219 34627670
Blood loss anaemia 30.14 11.21 20 329022 8174 34619715
Sudden death 30.09 11.21 61 328981 15140 34612749
Acute promyelocytic leukaemia 30.02 11.21 30 329012 475 34627414
Atrioventricular block first degree 29.88 11.21 10 329032 6082 34621807
Dysphonia 29.82 11.21 116 328926 23267 34604622
Hepatitis cholestatic 29.77 11.21 19 329023 7928 34619961
Anger 29.72 11.21 41 329001 11843 34616046
Toxic leukoencephalopathy 29.61 11.21 27 329015 379 34627510
Anal abscess 29.45 11.21 130 328912 6343 34621546
Chronic obstructive pulmonary disease 29.45 11.21 306 328736 48612 34579277
Tricuspid valve incompetence 29.44 11.21 29 329013 9731 34618158
Osteoporosis 29.25 11.21 212 328830 12456 34615433
Bladder transitional cell carcinoma recurrent 29.23 11.21 18 329024 132 34627757
Venous injury 29.22 11.21 24 329018 290 34627599
Bradyphrenia 29.16 11.21 5 329037 4793 34623096
Inflammatory pain 29.13 11.21 21 329021 206 34627683
Drug dependence 29.08 11.21 123 328919 24094 34603795
Poor venous access 29.04 11.21 111 328931 5072 34622817
Asthma 29.00 11.21 259 328783 42397 34585492
Asphyxia 28.99 11.21 14 329028 6821 34621068
Non-alcoholic steatohepatitis 28.93 11.21 40 329002 908 34626981
Shock 28.92 11.21 123 328919 24056 34603833
Mucosal ulceration 28.90 11.21 41 329001 954 34626935
Myelitis transverse 28.82 11.21 44 328998 1096 34626793
Pleuropericarditis 28.80 11.21 21 329021 210 34627679
Bicytopenia 28.73 11.21 67 328975 2317 34625572
T-cell lymphoma 28.71 11.21 41 329001 960 34626929
Cutaneous lymphoma 28.71 11.21 16 329026 95 34627794
Lung adenocarcinoma 28.66 11.21 103 328939 4568 34623321
Terminal ileitis 28.64 11.21 21 329021 212 34627677
Glycosylated haemoglobin increased 28.60 11.21 39 329003 11321 34616568
Abnormal dreams 28.55 11.21 18 329024 7560 34620329
Serum procollagen type III N-terminal propeptide increased 28.55 11.21 13 329029 46 34627843
Therapeutic product effect delayed 28.54 11.21 47 328995 1251 34626638
Sleep disorder due to a general medical condition 28.51 11.21 7 329035 5214 34622675
Swollen joint count increased 28.46 11.21 22 329020 242 34627647
Genital erosion 28.39 11.21 22 329020 243 34627646
Cerebral salt-wasting syndrome 28.34 11.21 13 329029 47 34627842
Product substitution issue 28.20 11.21 32 329010 10063 34617826
Neutrophil count increased 28.17 11.21 76 328966 17070 34610819
Neutropenic colitis 28.17 11.21 79 328963 3065 34624824
Gastric haemorrhage 28.15 11.21 33 329009 10228 34617661
Cardiac failure chronic 27.96 11.21 20 329022 7859 34620030
Mucosal erosion 27.87 11.21 37 329005 807 34627082
Osteosclerosis 27.85 11.21 47 328995 1277 34626612
Pseudostroke 27.81 11.21 12 329030 36 34627853
Tropical infectious disease 27.81 11.21 12 329030 36 34627853
Myelitis 27.77 11.21 37 329005 810 34627079
Prescribed underdose 27.57 11.21 26 329016 8907 34618982
Pachymeningitis 27.54 11.21 16 329026 104 34627785
Ventricular extrasystoles 27.52 11.21 44 328998 11964 34615925
Anal fissure 27.52 11.21 96 328946 4194 34623695
Gastric disorder 27.47 11.21 206 328836 12235 34615654
Meningitis tuberculous 27.33 11.21 33 329009 652 34627237
Leukopenia 27.28 11.21 780 328262 62076 34565813
Ischaemic cardiomyopathy 27.23 11.21 13 329029 6376 34621513
Skin mass 27.16 11.21 91 328951 3894 34623995
Circulatory collapse 27.06 11.21 104 328938 20934 34606955
Granulomatous pneumonitis 27.04 11.21 11 329031 27 34627862
Acute lymphocytic leukaemia 27.03 11.21 76 328966 2953 34624936
Hypogammaglobulinaemia 26.98 11.21 144 328898 7596 34620293
Glioblastoma multiforme 26.94 11.21 34 329008 704 34627185
Hypoxic-ischaemic encephalopathy 26.94 11.21 5 329037 4527 34623362
Diffuse large B-cell lymphoma recurrent 26.87 11.21 79 328963 3149 34624740
Epstein-Barr viraemia 26.84 11.21 46 328996 1266 34626623
Colitis 26.83 11.21 502 328540 37248 34590641
Granuloma 26.53 11.21 79 328963 3172 34624717
Mucosal toxicity 26.52 11.21 21 329021 240 34627649
Gliosis 26.47 11.21 19 329023 185 34627704
Lentigo 26.45 11.21 28 329014 476 34627413
Dysarthria 26.45 11.21 205 328837 34577 34593312
Chemotherapeutic drug level above therapeutic 26.45 11.21 9 329033 10 34627879
Adult T-cell lymphoma/leukaemia 26.40 11.21 17 329025 136 34627753
Intervertebral disc annular tear 26.28 11.21 10 329032 19 34627870
Intestinal sepsis 26.24 11.21 32 329010 639 34627250
Therapeutic product ineffective 26.17 11.21 35 329007 769 34627120
Defaecation urgency 26.15 11.21 68 328974 2521 34625368
Blood cholesterol increased 26.14 11.21 102 328940 20441 34607448
Blood alkaline phosphatase increased 25.98 11.21 179 328863 30996 34596893
Sweat gland tumour 25.95 11.21 26 329016 413 34627476
Parkinsonism 25.93 11.21 23 329019 8115 34619774
Cytomegalovirus test positive 25.84 11.21 88 328954 3798 34624091
Renal cell carcinoma 25.78 11.21 105 328937 4943 34622946
Pharyngeal inflammation 25.74 11.21 23 329019 314 34627575
Angioimmunoblastic T-cell lymphoma stage III 25.73 11.21 7 329035 0 34627889
Bone tuberculosis 25.73 11.21 25 329017 382 34627507
Taste disorder 25.60 11.21 18 329024 7137 34620752
Gastrointestinal inflammation 25.57 11.21 82 328960 3429 34624460
Meningitis haemophilus 25.56 11.21 8 329034 5 34627884
Hepatitis E 25.55 11.21 59 328983 2027 34625862
Thirst 25.54 11.21 22 329020 7873 34620016
Cytopenia 25.50 11.21 206 328836 12517 34615372
Ventricular hypertrophy 25.50 11.21 6 329036 4601 34623288
Joint warmth 25.42 11.21 25 329017 388 34627501
Polyuria 25.26 11.21 26 329016 8548 34619341
Nodular regenerative hyperplasia 25.23 11.21 38 329004 935 34626954
Infectious pleural effusion 25.08 11.21 65 328977 2405 34625484
Joint tuberculosis 25.02 11.21 11 329031 35 34627854
Swelling face 24.97 11.21 122 328920 22983 34604906
Hepatitis B reactivation 24.90 11.21 87 328955 3804 34624085
Graft versus host disease in eye 24.87 11.21 20 329022 234 34627655
Self-consciousness 24.87 11.21 12 329030 50 34627839
Actinomycotic pulmonary infection 24.76 11.21 9 329033 14 34627875
Listeriosis 24.76 11.21 39 329003 999 34626890
Herpes simplex oesophagitis 24.60 11.21 18 329024 181 34627708
Large intestinal stenosis 24.58 11.21 49 328993 1518 34626371
Limb deformity 24.41 11.21 29 329013 563 34627326
Faecaloma 24.40 11.21 10 329032 5367 34622522
Ependymoma malignant 24.39 11.21 9 329033 15 34627874
Acute monocytic leukaemia 24.38 11.21 23 329019 338 34627551
Nipple swelling 24.35 11.21 22 329020 305 34627584
Cerebral infarction 24.21 11.21 155 328887 27300 34600589
Septic arthritis staphylococcal 24.17 11.21 27 329015 489 34627400
Gastrooesophageal reflux disease 24.17 11.21 234 328808 37690 34590199
Prostatic specific antigen increased 24.17 11.21 65 328977 14615 34613274
Steatohepatitis 24.06 11.21 22 329020 310 34627579
Leishmaniasis 24.06 11.21 22 329020 310 34627579
Enzyme abnormality 24.00 11.21 20 329022 247 34627642
Nail dystrophy 23.87 11.21 20 329022 249 34627640
C-reactive protein decreased 23.84 11.21 56 328986 1946 34625943
Pneumonia cytomegaloviral 23.78 11.21 73 328969 2981 34624908
Mucocutaneous leishmaniasis 23.76 11.21 13 329029 74 34627815
Angina unstable 23.72 11.21 46 328996 11607 34616282
Cerebral toxoplasmosis 23.69 11.21 51 328991 1670 34626219
Schizophrenia 23.64 11.21 28 329014 8638 34619251
Tooth loss 23.61 11.21 85 328957 3773 34624116
Respiratory acidosis 23.56 11.21 9 329033 5041 34622848
Terminal state 23.50 11.21 86 328956 3848 34624041
Neck pain 23.49 11.21 352 328690 24997 34602892
Pulmonary arteriopathy 23.48 11.21 13 329029 76 34627813
Refusal of treatment by patient 23.42 11.21 9 329033 5023 34622866
Ageusia 23.41 11.21 38 329004 10270 34617619
Osteolysis 23.36 11.21 74 328968 3074 34624815
Blood magnesium decreased 23.19 11.21 16 329026 6407 34621482
Acute respiratory failure 23.18 11.21 183 328859 30745 34597144
Angioimmunoblastic T-cell lymphoma stage IV 23.01 11.21 8 329034 10 34627879
BK virus infection 22.97 11.21 111 328931 5627 34622262
Facial paresis 22.93 11.21 72 328970 2977 34624912
Blood glucose fluctuation 22.92 11.21 5 329037 4039 34623850
Dermatitis acneiform 22.91 11.21 15 329027 6174 34621715
Aspiration bone marrow abnormal 22.80 11.21 15 329027 125 34627764
Peritonsillar abscess 22.78 11.21 23 329019 369 34627520
Osteosarcoma recurrent 22.73 11.21 9 329033 20 34627869
Coma scale abnormal 22.62 11.21 5 329037 4003 34623886
Pemphigoid 22.58 11.21 29 329013 8637 34619252
Hepatic function abnormal 22.54 11.21 562 328480 43801 34584088
Psoriasis area severity index increased 22.48 11.21 10 329032 33 34627856
Atrioventricular block complete 22.46 11.21 33 329009 9286 34618603
Hepatitis B virus test positive 22.40 11.21 21 329021 306 34627583
Endocarditis bacterial 22.38 11.21 36 329006 939 34626950
Human herpesvirus 8 infection 22.38 11.21 36 329006 939 34626950
Electrocardiogram QRS complex prolonged 22.37 11.21 9 329033 4885 34623004
Muscle haemorrhage 22.32 11.21 4 329038 3714 34624175
Physical disability 22.25 11.21 44 328998 1355 34626534
Staphylococcal bacteraemia 22.21 11.21 146 328896 8306 34619583
Product complaint 22.18 11.21 14 329028 5876 34622013
Electrolyte imbalance 22.11 11.21 66 328976 14346 34613543
Blood pressure diastolic abnormal 22.10 11.21 97 328945 4721 34623168
Oropharyngeal oedema 22.07 11.21 13 329029 87 34627802
Antithrombin III decreased 22.03 11.21 21 329021 313 34627576
Prothrombin time prolonged 22.00 11.21 34 329008 9372 34618517
Body temperature decreased 21.92 11.21 203 328839 12831 34615058
Acute lymphocytic leukaemia refractory 21.85 11.21 14 329028 111 34627778
Refractoriness to platelet transfusion 21.84 11.21 12 329030 69 34627820
Electrocardiogram ST segment elevation 21.81 11.21 11 329031 5227 34622662
Rheumatoid vasculitis 21.76 11.21 19 329023 251 34627638
Psychomotor retardation 21.76 11.21 4 329038 3646 34624243
Flatulence 21.73 11.21 114 328928 21084 34606805
Herpes simplex encephalitis 21.71 11.21 21 329021 319 34627570
Pyopneumothorax 21.70 11.21 12 329030 70 34627819
Juvenile melanoma benign 21.70 11.21 12 329030 70 34627819
Toxoplasmosis 21.67 11.21 42 329000 1274 34626615
Epstein-Barr virus associated lymphoma 21.62 11.21 29 329013 639 34627250
Pneumocystis jirovecii infection 21.61 11.21 50 328992 1720 34626169
Transplant rejection 21.60 11.21 40 329002 10271 34617618
Coordination abnormal 21.60 11.21 24 329018 7620 34620269
International normalised ratio decreased 21.54 11.21 8 329034 4559 34623330
Subarachnoid haemorrhage 21.52 11.21 55 328987 12580 34615309
Corneal toxicity 21.45 11.21 7 329035 6 34627883
Synovectomy 21.43 11.21 12 329030 72 34627817
Meningitis aseptic 21.43 11.21 73 328969 3151 34624738
Lipodystrophy acquired 21.43 11.21 3 329039 3341 34624548
Haemorrhagic stroke 21.42 11.21 18 329024 6521 34621368
Escherichia infection 21.40 11.21 142 328900 8103 34619786
Meningitis staphylococcal 21.39 11.21 11 329031 54 34627835
Neutrophil count decreased 21.39 11.21 345 328697 50759 34577130
Tender joint count increased 21.35 11.21 17 329025 196 34627693
Iritis 21.34 11.21 44 328998 1397 34626492
Cheilitis 21.34 11.21 60 328982 2331 34625558
Spondylitis 21.31 11.21 41 329001 1237 34626652
Face oedema 21.30 11.21 48 328994 11468 34616421
Carcinoma in situ of skin 21.30 11.21 12 329030 73 34627816
JC virus infection 21.29 11.21 57 328985 2151 34625738
Empyema 21.27 11.21 73 328969 3163 34624726
Oesophageal stenosis 21.27 11.21 49 328993 1681 34626208
Mycobacterium haemophilum infection 21.26 11.21 13 329029 94 34627795
Tongue disorder 21.17 11.21 103 328939 5236 34622653
Tuberculous pleurisy 21.16 11.21 22 329020 366 34627523
Nail pitting 21.14 11.21 20 329022 295 34627594
Atrial septal defect 21.12 11.21 23 329019 7369 34620520
Cystitis escherichia 21.08 11.21 16 329026 171 34627718
Acute myelomonocytic leukaemia 21.05 11.21 14 329028 119 34627770
Cataract 21.01 11.21 355 328687 25831 34602058
Diarrhoea haemorrhagic 21.01 11.21 122 328920 6642 34621247
Cardiotoxicity 21.01 11.21 107 328935 5541 34622348
Ventricular arrhythmia 21.01 11.21 13 329029 5515 34622374
Atrioventricular block 20.99 11.21 27 329015 8036 34619853
Skin dystrophy 20.94 11.21 7 329035 7 34627882
Human rhinovirus test positive 20.93 11.21 17 329025 202 34627687
Hodgkin's disease 20.87 11.21 33 329009 848 34627041
Dry skin 20.81 11.21 191 328851 31096 34596793
Heart rate decreased 20.81 11.21 417 328625 31328 34596561
Haemodynamic instability 20.80 11.21 36 329006 9487 34618402
Adactyly 20.77 11.21 11 329031 58 34627831
Visual impairment 20.72 11.21 226 328816 35576 34592313
Neuroendocrine carcinoma of the skin 20.66 11.21 31 329011 760 34627129
C-reactive protein 20.49 11.21 14 329028 125 34627764
Cerebral fungal infection 20.48 11.21 19 329023 273 34627616
Lennox-Gastaut syndrome 20.48 11.21 10 329032 43 34627846
Herpes simplex 20.46 11.21 105 328937 5454 34622435
Anal squamous cell carcinoma 20.29 11.21 13 329029 103 34627786
Epstein-Barr virus test positive 20.29 11.21 26 329016 547 34627342
Alopecia 20.21 11.21 332 328710 24023 34603866
Mycobacterium marinum infection 20.21 11.21 19 329023 278 34627611
Atrial septal defect acquired 20.14 11.21 8 329034 18 34627871
Ophthalmic herpes zoster 20.13 11.21 33 329009 875 34627014
Acute coronary syndrome 20.09 11.21 63 328979 13482 34614407
Shoulder arthroplasty 20.08 11.21 24 329018 469 34627420
Urticaria 20.06 11.21 747 328295 61630 34566259
Second primary malignancy 19.98 11.21 135 328907 7751 34620138
Keratitis 19.98 11.21 43 328999 1408 34626481
Thymus enlargement 19.96 11.21 10 329032 46 34627843
Epstein-Barr virus antigen positive 19.94 11.21 9 329033 31 34627858
Acute pulmonary histoplasmosis 19.94 11.21 15 329027 158 34627731
Colorectal cancer 19.82 11.21 10 329032 4751 34623138
Injection site papule 19.80 11.21 20 329022 321 34627568
Macule 19.80 11.21 44 328998 1473 34626416
Legionella infection 19.69 11.21 24 329018 479 34627410
Bone marrow transplant rejection 19.64 11.21 16 329026 191 34627698
Urinary incontinence 19.63 11.21 101 328941 18773 34609116
Neutropenia 19.59 11.21 1722 327320 155056 34472833
Hypothyroidism 19.47 11.21 116 328926 20786 34607103
Paraplegia 19.42 11.21 66 328976 2845 34625044
Hypersensitivity pneumonitis 19.41 11.21 45 328997 1550 34626339
Musculoskeletal disorder 19.34 11.21 112 328930 6092 34621797
Mesenteritis 19.32 11.21 9 329033 34 34627855
Muscle swelling 19.30 11.21 21 329021 369 34627520
Granulomatosis with polyangiitis 19.29 11.21 38 329004 1167 34626722
Granulocytopenia 19.25 11.21 20 329022 6547 34621342
Cytokine release syndrome 19.24 11.21 131 328911 22746 34605143
Increased appetite 19.22 11.21 25 329017 7404 34620485
Mucosal disorder 19.18 11.21 47 328995 1679 34626210
Blood thyroid stimulating hormone increased 19.17 11.21 8 329034 4247 34623642
International normalised ratio abnormal 19.15 11.21 4 329038 3331 34624558
Iron deficiency anaemia 19.15 11.21 43 328999 10286 34617603
Somnambulism 19.12 11.21 3 329039 3069 34624820
Knee operation 19.09 11.21 53 328989 2044 34625845
Dermatitis psoriasiform 19.09 11.21 43 328999 1453 34626436
Infectious thyroiditis 19.05 11.21 12 329030 92 34627797
Chills 19.05 11.21 599 328443 80444 34547445
Pericarditis tuberculous 19.00 11.21 11 329031 71 34627818
Varicella 18.99 11.21 46 328996 1631 34626258
Cerebral thrombosis 18.96 11.21 34 329008 971 34626918
Symptom recurrence 18.95 11.21 29 329013 724 34627165
Low density lipoprotein increased 18.95 11.21 9 329033 4427 34623462
Hypersomnia 18.91 11.21 57 328985 12350 34615539
Cholangitis 18.84 11.21 33 329009 8656 34619233
Escherichia sepsis 18.84 11.21 91 328951 4613 34623276
Hyperthermia 18.83 11.21 45 328997 10532 34617357
Ligament calcification 18.79 11.21 16 329026 204 34627685
Atypical haemolytic uraemic syndrome 18.76 11.21 19 329023 306 34627583
Disseminated toxoplasmosis 18.75 11.21 11 329031 73 34627816
Iris adhesions 18.74 11.21 17 329025 237 34627652
Spinal cord disorder 18.69 11.21 31 329011 830 34627059
Encephalitis 18.69 11.21 125 328917 7152 34620737
Meningitis chemical 18.63 11.21 11 329031 74 34627815
White matter lesion 18.61 11.21 30 329012 784 34627105
Sinusitis fungal 18.57 11.21 25 329017 553 34627336
Urine output decreased 18.50 11.21 42 329000 10007 34617882
Paraesthesia 18.49 11.21 461 328581 63711 34564178
Nocardiosis 18.47 11.21 80 328962 3871 34624018
Humoral immune defect 18.42 11.21 15 329027 179 34627710
Central nervous system lymphoma 18.40 11.21 34 329008 994 34626895
Heavy chain disease 18.38 11.21 5 329037 0 34627889
Oral toxicity 18.38 11.21 5 329037 0 34627889
Pharyngitis 18.37 11.21 133 328909 7811 34620078
Cutaneous symptom 18.37 11.21 18 329024 278 34627611
Blood testosterone decreased 18.36 11.21 9 329033 4348 34623541
Muscle spasticity 18.34 11.21 17 329025 5871 34622018
Post inflammatory pigmentation change 18.32 11.21 18 329024 279 34627610
Sudden cardiac death 18.28 11.21 6 329036 3695 34624194
Pain of skin 18.21 11.21 109 328933 6000 34621889
Oral surgery 18.20 11.21 25 329017 564 34627325
Myocardial ischaemia 18.19 11.21 93 328949 17315 34610574
Osteomyelitis 18.17 11.21 232 328810 15904 34611985
Psychomotor skills impaired 18.16 11.21 7 329035 3899 34623990
Body temperature fluctuation 18.10 11.21 45 328997 1622 34626267
Trichosporon infection 18.09 11.21 28 329014 706 34627183
Exposure to toxic agent 18.08 11.21 6 329036 3669 34624220
Mood swings 18.06 11.21 29 329013 7872 34620017
Follicular lymphoma 18.04 11.21 14 329028 155 34627734
Tinea versicolour 18.00 11.21 19 329023 322 34627567
Tonsillar disorder 17.99 11.21 16 329026 217 34627672
Leukodystrophy 17.95 11.21 6 329036 6 34627883
Exostosis 17.94 11.21 90 328952 4633 34623256
Drug level below therapeutic 17.92 11.21 102 328940 5513 34622376
Medication error 17.91 11.21 154 328888 25411 34602478
Euphoric mood 17.91 11.21 16 329026 5625 34622264
Micturition urgency 17.88 11.21 21 329021 6504 34621385
Fistula 17.88 11.21 118 328924 6722 34621167
Monoclonal B-cell lymphocytosis 17.85 11.21 8 329034 27 34627862
Cystitis viral 17.82 11.21 24 329018 531 34627358
Mental disorder 17.80 11.21 78 328964 15131 34612758
Bundle branch block left 17.76 11.21 18 329024 5961 34621928
Neoplasm recurrence 17.74 11.21 54 328988 2195 34625694
Intestinal stenosis 17.72 11.21 53 328989 2133 34625756
Amyloidosis 17.72 11.21 52 328990 2071 34625818
Sickle cell anaemia with crisis 17.66 11.21 8 329034 4045 34623844
Prescribed overdose 17.63 11.21 47 328995 10600 34617289
Bronchiolitis obliterans syndrome 17.63 11.21 15 329027 191 34627698
Lymphopenia 17.62 11.21 233 328809 16102 34611787
Protein urine present 17.61 11.21 14 329028 5214 34622675
Dyspnoea at rest 17.56 11.21 7 329035 3821 34624068
Blood pressure diastolic decreased 17.56 11.21 146 328896 8948 34618941
Ketoacidosis 17.53 11.21 9 329033 4234 34623655
Arteriosclerosis 17.52 11.21 56 328986 11912 34615977
Neonatal respiratory distress syndrome 17.51 11.21 8 329034 4026 34623863
Catatonia 17.51 11.21 13 329029 5012 34622877
Micrognathia 17.48 11.21 18 329024 296 34627593
Gallbladder oedema 17.47 11.21 16 329026 226 34627663
Faecal calprotectin abnormal 17.47 11.21 16 329026 226 34627663
Eye infection toxoplasmal 17.47 11.21 16 329026 226 34627663
Small cell lung cancer metastatic 17.45 11.21 19 329023 334 34627555
Mixed liver injury 17.45 11.21 3 329039 2870 34625019
Depressive symptom 17.33 11.21 3 329039 2856 34625033
Malignant melanoma stage I 17.29 11.21 11 329031 86 34627803
Glottis carcinoma 17.26 11.21 7 329035 17 34627872
Bursitis infective staphylococcal 17.26 11.21 7 329035 17 34627872
Product administration error 17.26 11.21 87 328955 16257 34611632
Lung neoplasm 17.22 11.21 88 328954 4563 34623326
Ischaemic stroke 17.15 11.21 101 328941 18149 34609740
Herpes zoster oticus 17.13 11.21 15 329027 199 34627690
Thrombosis in device 17.13 11.21 5 329037 3320 34624569
Systemic lupus erythematosus 17.10 11.21 75 328967 3649 34624240
Bone sarcoma 17.09 11.21 10 329032 66 34627823
Mucosal necrosis 17.09 11.21 10 329032 66 34627823
Degenerative bone disease 17.09 11.21 10 329032 66 34627823
Splenic infection fungal 17.09 11.21 11 329031 88 34627801
Mydriasis 17.08 11.21 26 329016 7211 34620678
Dysplastic naevus syndrome 17.04 11.21 6 329036 8 34627881
Polychondritis 17.02 11.21 16 329026 234 34627655
Temporal lobe epilepsy 16.99 11.21 14 329028 170 34627719
Ammonia increased 16.99 11.21 10 329032 4359 34623530
Silicosis 16.98 11.21 7 329035 18 34627871
Mediastinal mass 16.92 11.21 14 329028 171 34627718
Precursor T-lymphoblastic lymphoma/leukaemia 16.92 11.21 9 329033 48 34627841
Enterovirus infection 16.89 11.21 32 329010 954 34626935
Arthroscopy 16.88 11.21 11 329031 90 34627799
Hypotonia 16.87 11.21 30 329012 7823 34620066
Herpes virus infection 16.87 11.21 62 328980 2780 34625109
Gastrointestinal wall thickening 16.86 11.21 41 329001 1457 34626432
Nephrolithiasis 16.84 11.21 389 328653 29944 34597945
Thyroid cancer 16.84 11.21 44 328998 1636 34626253
Phototherapy 16.83 11.21 8 329034 32 34627857
Gout 16.82 11.21 109 328933 19144 34608745
Panniculitis 16.79 11.21 49 328993 1945 34625944
Anaplastic large cell lymphoma T- and null-cell types 16.79 11.21 11 329031 91 34627798
Acute pulmonary oedema 16.74 11.21 27 329015 7316 34620573
Infective tenosynovitis 16.73 11.21 10 329032 69 34627820
Behaviour disorder 16.73 11.21 13 329029 4897 34622992
Toxic epidermal necrolysis 16.73 11.21 127 328915 21519 34606370
Pseudomonal sepsis 16.72 11.21 72 328970 3475 34624414
Cerebrosclerosis 16.72 11.21 7 329035 19 34627870
Dialysis 16.72 11.21 52 328990 11156 34616733
Fusarium infection 16.69 11.21 35 329007 1125 34626764
Post procedural infection 16.69 11.21 90 328952 4766 34623123
Osteosarcoma 16.68 11.21 17 329025 276 34627613
Adenoviral hepatitis 16.67 11.21 23 329019 521 34627368
Steroid diabetes 16.66 11.21 52 328990 2143 34625746
Ulcer 16.61 11.21 141 328901 8694 34619195
Blood pressure diastolic increased 16.51 11.21 92 328950 4933 34622956
Scab 16.50 11.21 87 328955 4567 34623322
Antisynthetase syndrome 16.50 11.21 10 329032 71 34627818
Hepatic candidiasis 16.48 11.21 9 329033 51 34627838
Pulmonary congestion 16.47 11.21 70 328972 13695 34614194
Injection site erythema 16.41 11.21 225 328817 15674 34612215
Cytomegalovirus hepatitis 16.38 11.21 21 329021 442 34627447
Sinus tachycardia 16.35 11.21 96 328946 17264 34610625
Extradural abscess 16.32 11.21 29 329013 822 34627067
Low birth weight baby 16.27 11.21 31 329011 7874 34620015
Inadequate analgesia 16.22 11.21 4 329038 2971 34624918
Q fever 16.22 11.21 12 329030 123 34627766
Stomatitis haemorrhagic 16.21 11.21 9 329033 53 34627836
Hepatic failure 16.20 11.21 228 328814 34303 34593586
Retinal pigment epitheliopathy 16.20 11.21 15 329027 215 34627674
Atrial tachycardia 16.18 11.21 7 329035 3638 34624251
N-terminal prohormone brain natriuretic peptide increased 16.13 11.21 3 329039 2712 34625177
Cutaneous tuberculosis 16.12 11.21 11 329031 98 34627791
Autoimmune lymphoproliferative syndrome 16.11 11.21 13 329029 153 34627736
Joint abscess 16.06 11.21 12 329030 125 34627764
Viral mutation identified 16.05 11.21 4 329038 2950 34624939
Infusion related reaction 16.01 11.21 631 328411 52426 34575463
Joint injury 16.00 11.21 144 328898 9029 34618860
Chronic graft versus host disease oral 15.98 11.21 12 329030 126 34627763
Cushingoid 15.93 11.21 59 328983 2655 34625234
Visual acuity reduced 15.91 11.21 88 328954 16061 34611828
Subcutaneous abscess 15.86 11.21 75 328967 3768 34624121
Cyanosis 15.84 11.21 64 328978 12700 34615189
Cardiomegaly 15.84 11.21 83 328959 15355 34612534
Tonsillar ulcer 15.83 11.21 13 329029 157 34627732
Infective myositis 15.81 11.21 9 329033 56 34627833
Diffuse large B-cell lymphoma stage III 15.81 11.21 9 329033 56 34627833
Muscle strength abnormal 15.79 11.21 14 329028 189 34627700
Cardiac failure acute 15.79 11.21 49 328993 10521 34617368
Thrombosis 15.77 11.21 358 328684 50100 34577789
Chronic actinic dermatitis 15.76 11.21 7 329035 23 34627866
Secondary amyloidosis 15.74 11.21 10 329032 78 34627811
Meningitis enterococcal 15.74 11.21 10 329032 78 34627811
Vitreous floaters 15.74 11.21 7 329035 3578 34624311
Tearfulness 15.73 11.21 3 329039 2664 34625225
Diffuse large B-cell lymphoma refractory 15.72 11.21 36 329006 1230 34626659
Onycholysis 15.71 11.21 27 329015 745 34627144
Bladder neoplasm 15.64 11.21 38 329004 1350 34626539
Stem cell transplant 15.62 11.21 50 328992 2089 34625800
Morphoea 15.62 11.21 14 329028 192 34627697
Stupor 15.54 11.21 4 329038 2887 34625002
Eructation 15.53 11.21 13 329029 4718 34623171
Extranodal marginal zone B-cell lymphoma (MALT type) 15.50 11.21 14 329028 194 34627695
Skin injury 15.50 11.21 53 328989 2292 34625597
Nocturia 15.49 11.21 47 328995 10163 34617726
Steroid dependence 15.48 11.21 40 329002 1477 34626412
Hepatitis acute 15.48 11.21 30 329012 7571 34620318
Activated partial thromboplastin time prolonged 15.47 11.21 37 329005 8658 34619231
Lower gastrointestinal haemorrhage 15.45 11.21 42 329000 9410 34618479
Meningoencephalitis herpetic 15.43 11.21 28 329014 807 34627082
Graft versus host disease in lung 15.42 11.21 23 329019 561 34627328
Capnocytophaga infection 15.42 11.21 11 329031 106 34627783
Genital ulceration 15.39 11.21 20 329022 427 34627462
Abscess intestinal 15.38 11.21 42 329000 1604 34626285
Hemiparesis 15.37 11.21 221 328821 15557 34612332
Dysstasia 15.32 11.21 179 328863 12016 34615873
Atypical mycobacterial infection 15.32 11.21 29 329013 864 34627025
Iridocyclitis 15.28 11.21 42 329000 1610 34626279
Remission not achieved 15.25 11.21 11 329031 108 34627781
Muscle oedema 15.25 11.21 13 329029 166 34627723
Erythema multiforme 15.24 11.21 37 329005 8612 34619277
Squamous cell carcinoma of the tongue 15.22 11.21 17 329025 308 34627581
Laboratory test abnormal 15.12 11.21 121 328921 20270 34607619
Diastolic dysfunction 15.06 11.21 22 329020 6205 34621684
Alveolitis 15.04 11.21 43 328999 1687 34626202
Bradykinesia 15.01 11.21 9 329033 3884 34624005
Therapy interrupted 14.99 11.21 72 328970 13625 34614264
Communication disorder 14.96 11.21 3 329039 2571 34625318
Bladder neck operation 14.96 11.21 5 329037 5 34627884
Yolk sac tumour site unspecified 14.96 11.21 5 329037 5 34627884
Injection site reaction 14.94 11.21 188 328854 12845 34615044
Osteomyelitis salmonella 14.92 11.21 7 329035 27 34627862
Fine motor skill dysfunction 14.91 11.21 44 328998 1758 34626131
Demyelinating polyneuropathy 14.90 11.21 35 329007 1216 34626673
Hypercapnia 14.84 11.21 11 329031 4244 34623645
Tendon disorder 14.84 11.21 60 328982 2815 34625074
Pneumonia adenoviral 14.78 11.21 18 329024 359 34627530
Palmoplantar pustulosis 14.77 11.21 11 329031 114 34627775
Myoglobin blood increased 14.76 11.21 5 329037 3018 34624871
Cerebral haematoma 14.76 11.21 13 329029 4602 34623287
Enterovesical fistula 14.74 11.21 27 329015 784 34627105
Immune recovery uveitis 14.72 11.21 7 329035 28 34627861
Compartment syndrome 14.72 11.21 5 329037 3013 34624876
Azotaemia 14.70 11.21 15 329027 4952 34622937
Dysphotopsia 14.70 11.21 4 329038 0 34627889
Rheumatoid arthritis-associated interstitial lung disease 14.70 11.21 4 329038 0 34627889
Fear-related avoidance of activities 14.70 11.21 4 329038 0 34627889
Limbal stem cell deficiency 14.68 11.21 6 329036 15 34627874
Anti-saccharomyces cerevisiae antibody 14.68 11.21 6 329036 15 34627874
Gynaecomastia 14.64 11.21 48 328994 10132 34617757
Multiple allergies 14.61 11.21 5 329037 2998 34624891
Sleep disorder 14.60 11.21 210 328832 31478 34596411
Proteinuria 14.58 11.21 109 328933 18533 34609356
Ankle fracture 14.55 11.21 77 328965 4048 34623841
Nervousness 14.54 11.21 65 328977 12541 34615348
Throat tightness 14.53 11.21 36 329006 8322 34619567
Bursa disorder 14.51 11.21 14 329028 212 34627677
Hyperuricaemia 14.49 11.21 34 329008 8009 34619880
Pulmonary cavitation 14.49 11.21 29 329013 901 34626988
Crohn's disease 14.49 11.21 63 328979 3054 34624835
Vascular access complication 14.47 11.21 17 329025 326 34627563
T-cell type acute leukaemia 14.46 11.21 11 329031 118 34627771
Nephrogenic systemic fibrosis 14.43 11.21 10 329032 3995 34623894
Hyperlipidaemia 14.41 11.21 79 328963 14450 34613439
Purulent pericarditis 14.41 11.21 6 329036 16 34627873
Stress ulcer 14.40 11.21 9 329033 68 34627821
Muscle abscess 14.38 11.21 23 329019 597 34627292
Myocarditis 14.35 11.21 73 328969 13609 34614280
Organising pneumonia 14.35 11.21 101 328941 5878 34622011
Small cell lung cancer 14.34 11.21 45 328997 1860 34626029
Splenic lesion 14.31 11.21 15 329027 252 34627637
Bacterial infection 14.31 11.21 233 328809 16830 34611059
Haematopoietic neoplasm 14.29 11.21 8 329034 48 34627841
Antinuclear antibody positive 14.28 11.21 37 329005 1369 34626520
Arteriospasm coronary 14.23 11.21 7 329035 3375 34624514
Cardiac murmur 14.23 11.21 33 329009 7804 34620085
Aplastic anaemia 14.22 11.21 147 328895 9569 34618320
Stenotrophomonas infection 14.22 11.21 48 328994 2062 34625827
Disseminated aspergillosis 14.22 11.21 26 329016 754 34627135
Accidental exposure to product 14.18 11.21 67 328975 12735 34615154
Ossicle disorder 14.18 11.21 7 329035 31 34627858
Cutaneous T-cell lymphoma stage III 14.18 11.21 7 329035 31 34627858
Systemic candida 14.15 11.21 71 328971 3655 34624234
Liver function test abnormal 14.14 11.21 388 328654 30686 34597203
Pericardial haemorrhage 14.13 11.21 6 329036 3152 34624737
Cyst rupture 14.08 11.21 9 329033 71 34627818
Alcohol abuse 14.07 11.21 14 329028 4676 34623213
Anaemia megaloblastic 14.06 11.21 13 329029 186 34627703
Therapeutic product effect variable 13.99 11.21 3 329039 2453 34625436
Cauda equina syndrome 13.95 11.21 22 329020 564 34627325
Joint space narrowing 13.95 11.21 13 329029 188 34627701
Nasal septum perforation 13.94 11.21 11 329031 125 34627764
Hallucinations, mixed 13.93 11.21 4 329038 2685 34625204
Blood cholesterol abnormal 13.91 11.21 43 328999 1763 34626126
Interferon gamma release assay positive 13.90 11.21 6 329036 18 34627871
Small for dates baby 13.89 11.21 10 329032 3917 34623972
Seasonal allergy 13.89 11.21 26 329016 6649 34621240
B-cell lymphoma stage IV 13.88 11.21 9 329033 73 34627816
Inflammatory myofibroblastic tumour 13.87 11.21 11 329031 126 34627763
Cancer pain 13.80 11.21 4 329038 2668 34625221
Plasma cell myeloma recurrent 13.78 11.21 13 329029 4452 34623437
Pancreatic neoplasm 13.77 11.21 28 329014 880 34627009
West Nile viral infection 13.74 11.21 25 329017 722 34627167
Salivary gland cancer 13.73 11.21 16 329026 304 34627585
Nasal cavity cancer 13.73 11.21 13 329029 192 34627697
Glomerular filtration rate decreased 13.68 11.21 69 328973 12892 34614997
Ear canal stenosis 13.67 11.21 5 329037 8 34627881
Encephalitis Japanese B 13.67 11.21 6 329036 19 34627870
Muscular weakness 13.66 11.21 554 328488 72343 34555546
Chimerism 13.65 11.21 14 329028 229 34627660
Brain abscess 13.65 11.21 62 328980 3063 34624826
Chronic myeloid leukaemia 13.61 11.21 49 328993 2175 34625714
Haemorrhage intracranial 13.56 11.21 91 328951 15855 34612034
Aplasia pure red cell 13.56 11.21 23 329019 6109 34621780
Lower respiratory tract infection 13.55 11.21 392 328650 31245 34596644
Tooth abscess 13.54 11.21 98 328944 5755 34622134
Therapy change 13.52 11.21 6 329036 3071 34624818
Meningitis 13.52 11.21 85 328957 4762 34623127
Blood glucose abnormal 13.46 11.21 22 329020 5930 34621959
Encephalitis viral 13.46 11.21 33 329009 1179 34626710
Blood pressure systolic abnormal 13.45 11.21 73 328969 3875 34624014
Adenoviral haemorrhagic cystitis 13.44 11.21 18 329024 396 34627493
Blood culture positive 13.41 11.21 84 328958 4699 34623190
Viral vasculitis 13.39 11.21 9 329033 78 34627811
Left ventricular hypertrophy 13.38 11.21 36 329006 8094 34619795
Appendicitis 13.36 11.21 83 328959 14724 34613165
Lower motor neurone lesion 13.36 11.21 7 329035 36 34627853
Cartilage injury 13.36 11.21 21 329021 537 34627352
Rash pruritic 13.32 11.21 176 328866 26765 34601124
Body height decreased 13.32 11.21 10 329032 3833 34624056
Musculoskeletal deformity 13.31 11.21 5 329037 9 34627880
CSF myelin basic protein increased 13.31 11.21 5 329037 9 34627880
Impaired gastric emptying 13.29 11.21 8 329034 3445 34624444
Tension headache 13.26 11.21 6 329036 3036 34624853
Meniscus injury 13.25 11.21 49 328993 2204 34625685
Scleritis 13.19 11.21 21 329021 543 34627346
Ankle operation 13.18 11.21 14 329028 239 34627650
Liver injury 13.17 11.21 205 328837 14673 34613216
Enuresis 13.15 11.21 3 329039 2350 34625539
Scedosporium infection 13.15 11.21 27 329015 855 34627034
Feeling jittery 13.14 11.21 11 329031 3992 34623897
Ventricular septal defect 13.12 11.21 11 329031 3990 34623899
Intestinal atresia 13.12 11.21 9 329033 81 34627808
Blood chloride decreased 13.11 11.21 10 329032 3803 34624086
Limb operation 13.11 11.21 25 329017 749 34627140
Folate deficiency 13.07 11.21 33 329009 1201 34626688
Hyperlactacidaemia 13.06 11.21 6 329036 3010 34624879
Septic shock 13.03 11.21 813 328229 71021 34556868
Bronchoalveolar lavage abnormal 13.03 11.21 9 329033 82 34627807
Encephalitis brain stem 13.03 11.21 9 329033 82 34627807
Abscess sterile 13.02 11.21 6 329036 22 34627867
Skin bacterial infection 13.01 11.21 10 329032 109 34627780
SAPHO syndrome 13.00 11.21 15 329027 282 34627607
Meningitis noninfective 12.98 11.21 5 329037 10 34627879
Post lumbar puncture syndrome 12.95 11.21 13 329029 207 34627682
Blood beta-D-glucan increased 12.94 11.21 18 329024 411 34627478
Superior mesenteric artery syndrome 12.94 11.21 9 329033 83 34627806
Joint noise 12.87 11.21 23 329019 655 34627234
Rebound effect 12.87 11.21 63 328979 3211 34624678
Loss of libido 12.85 11.21 4 329038 2548 34625341
Abscess bacterial 12.85 11.21 12 329030 174 34627715
Mitral valve incompetence 12.85 11.21 85 328957 14858 34613031
Testicular seminoma (pure) 12.85 11.21 8 329034 60 34627829
Investigation abnormal 12.85 11.21 20 329022 507 34627382
Oesophageal squamous cell carcinoma 12.83 11.21 17 329025 370 34627519
Central nervous system infection 12.82 11.21 23 329019 657 34627232
Double stranded DNA antibody 12.81 11.21 6 329036 23 34627866
Laboratory test interference 12.81 11.21 19 329023 461 34627428
Gastrointestinal infection 12.80 11.21 96 328946 5702 34622187
Ocular hypertension 12.77 11.21 26 329016 818 34627071
Coronary arterial stent insertion 12.76 11.21 12 329030 4117 34623772
Skin infection 12.76 11.21 120 328922 7617 34620272
Strongyloidiasis 12.76 11.21 55 328987 2656 34625233
Respiration abnormal 12.73 11.21 7 329035 3169 34624720
Burkitt's lymphoma 12.72 11.21 10 329032 113 34627776
Staphylococcal infection 12.71 11.21 401 328641 32359 34595530
Polyarteritis nodosa 12.71 11.21 15 329027 289 34627600
Transfusion 12.68 11.21 40 329002 8545 34619344
Scrotal cancer 12.66 11.21 5 329037 11 34627878
Purulent discharge 12.65 11.21 57 328985 2806 34625083
Spinal fusion surgery 12.64 11.21 29 329013 992 34626897
Mycobacterium avium complex infection 12.64 11.21 52 328990 2459 34625430
Meningitis viral 12.63 11.21 27 329015 880 34627009
Chronic hepatitis 12.60 11.21 23 329019 666 34627223
Respiratory failure 12.59 11.21 866 328176 107706 34520183
Hot flush 12.58 11.21 109 328933 17957 34609932
Exposure to communicable disease 12.56 11.21 11 329031 146 34627743
Herpes ophthalmic 12.54 11.21 21 329021 567 34627322
Xanthogranuloma 12.53 11.21 8 329034 63 34627826
Small fibre neuropathy 12.51 11.21 9 329033 88 34627801
Personality change due to a general medical condition 12.50 11.21 7 329035 42 34627847
Depression suicidal 12.48 11.21 4 329038 2501 34625388
Mucous stools 12.47 11.21 41 329001 1737 34626152
Vascular stent thrombosis 12.47 11.21 6 329036 2929 34624960
Wrist surgery 12.44 11.21 11 329031 148 34627741
Extrapulmonary tuberculosis 12.42 11.21 9 329033 89 34627800
Mucosal infection 12.42 11.21 13 329029 218 34627671
Blood urine present 12.42 11.21 56 328986 10778 34617111
Diabetes mellitus inadequate control 12.39 11.21 75 328967 13389 34614500
Echinococciasis 12.37 11.21 5 329037 12 34627877
Oxygen saturation decreased 12.35 11.21 399 328643 53419 34574470
Pneumoconiosis 12.33 11.21 13 329029 220 34627669
Hand fracture 12.33 11.21 47 328995 2145 34625744
Thyroid gland abscess 12.33 11.21 8 329034 65 34627824
Injection site rash 12.32 11.21 74 328968 4079 34623810
Haemodialysis 12.31 11.21 54 328988 10472 34617417
Diffuse large B-cell lymphoma stage IV 12.30 11.21 14 329028 259 34627630
Social avoidant behaviour 12.29 11.21 7 329035 3107 34624782
Solar urticaria 12.25 11.21 6 329036 26 34627863
Mycobacterium chelonae infection 12.21 11.21 25 329017 790 34627099
Suspected product quality issue 12.20 11.21 11 329031 152 34627737
Muscle spasms 12.20 11.21 579 328463 74422 34553467
Acanthosis 12.16 11.21 10 329032 121 34627768
Infusion site pain 12.13 11.21 11 329031 3840 34624049
Alcohol use 12.13 11.21 8 329034 3280 34624609
Diffuse idiopathic skeletal hyperostosis 12.11 11.21 7 329035 45 34627844
Hepatitis infectious mononucleosis 12.11 11.21 7 329035 45 34627844
Infective aneurysm 12.10 11.21 21 329021 584 34627305
Ewing's sarcoma 12.09 11.21 5 329037 13 34627876
Crystal nephropathy 12.07 11.21 18 329024 439 34627450
Eye irritation 12.06 11.21 34 329008 7527 34620362
Nail disorder 12.04 11.21 45 328997 2034 34625855
Systemic infection 12.04 11.21 19 329023 5193 34622696
Atrial thrombosis 12.03 11.21 3 329039 2211 34625678
Human herpesvirus 6 infection 12.02 11.21 45 328997 2036 34625853
Palindromic rheumatism 12.01 11.21 12 329030 190 34627699
Metastatic neoplasm 11.99 11.21 58 328984 2942 34624947
Muscle enzyme increased 11.98 11.21 14 329028 267 34627622
Bacterial myositis 11.97 11.21 4 329038 4 34627885
Endotracheal intubation 11.94 11.21 7 329035 3058 34624831
Spinal cord oedema 11.91 11.21 12 329030 192 34627697
Cryptococcal fungaemia 11.87 11.21 9 329033 96 34627793
Tuberculosis liver 11.87 11.21 7 329035 47 34627842
Sleep apnoea syndrome 11.87 11.21 128 328914 20193 34607696
Tendonitis 11.86 11.21 135 328907 9005 34618884
Radiation pneumonitis 11.83 11.21 5 329037 2635 34625254
Lymphadenitis 11.83 11.21 44 328998 1984 34625905
Drainage 11.83 11.21 5 329037 14 34627875
Tender joint count 11.83 11.21 5 329037 14 34627875
Perirectal abscess 11.77 11.21 39 329003 1659 34626230
Hepatocellular injury 11.77 11.21 283 328759 21928 34605961
Cyst 11.76 11.21 78 328964 4450 34623439
Pseudolymphoma 11.75 11.21 22 329020 650 34627239
Infected dermal cyst 11.75 11.21 26 329016 868 34627021
Hepatosplenic candidiasis 11.75 11.21 13 329029 233 34627656
Inflammatory pseudotumour 11.74 11.21 6 329036 29 34627860
Nail injury 11.74 11.21 6 329036 29 34627860
Lumbosacral radiculopathy 11.71 11.21 10 329032 128 34627761
Microangiopathy 11.70 11.21 27 329015 927 34626962
Pneumatosis intestinalis 11.70 11.21 70 328972 3853 34624036
CNS ventriculitis 11.70 11.21 14 329028 274 34627615
Pallor 11.69 11.21 169 328873 25311 34602578
Myeloid leukaemia 11.66 11.21 17 329025 406 34627483
Elbow operation 11.65 11.21 10 329032 129 34627760
Xyphoid retraction 11.64 11.21 11 329031 162 34627727
Tinnitus 11.64 11.21 127 328915 19991 34607898
Incorrect product administration duration 11.63 11.21 17 329025 4794 34623095
Emphysema 11.61 11.21 139 328903 9386 34618503
Restless legs syndrome 11.60 11.21 40 329002 8314 34619575
Neoplasm malignant 11.59 11.21 257 328785 19648 34608241
Renal injury 11.59 11.21 60 328982 11135 34616754
Rocky mountain spotted fever 11.59 11.21 5 329037 15 34627874
Enzyme level increased 11.53 11.21 11 329031 164 34627725
Normochromic normocytic anaemia 11.53 11.21 14 329028 4273 34623616
Oral pustule 11.53 11.21 13 329029 238 34627651
Synostosis 11.50 11.21 9 329033 101 34627788
Incoherent 11.50 11.21 15 329027 4437 34623452
Rheumatoid factor 11.48 11.21 8 329034 74 34627815
Blood triglycerides increased 11.45 11.21 82 328960 14077 34613812
Cardiomyopathy 11.44 11.21 102 328940 16706 34611183
Angiotensin converting enzyme increased 11.39 11.21 8 329034 75 34627814
Furuncle 11.38 11.21 62 328980 3296 34624593
Candida infection 11.37 11.21 232 328810 17483 34610406
Thyroiditis 11.37 11.21 4 329038 2358 34625531
Actinomycosis 11.37 11.21 18 329024 463 34627426
Hypomania 11.35 11.21 4 329038 2355 34625534
Prostate infection 11.33 11.21 27 329015 947 34626942
Total cholesterol/HDL ratio decreased 11.29 11.21 7 329035 52 34627837
Spinal cord abscess 11.28 11.21 13 329029 244 34627645
Immobile 11.28 11.21 50 328992 2444 34625445
HLA-B*27 positive 11.28 11.21 6 329036 32 34627857
Undifferentiated connective tissue disease 11.28 11.21 6 329036 32 34627857
Cell marker increased 11.27 11.21 17 329025 419 34627470
Alanine aminotransferase increased 11.24 11.21 895 328147 79920 34547969
Attention deficit hyperactivity disorder 11.23 11.21 5 329037 2554 34625335
Superficial spreading melanoma stage unspecified 11.22 11.21 11 329031 170 34627719

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 12867.34 11.34 36579 993458 1044334 77670017
Drug intolerance 5075.77 11.34 10793 1019244 253326 78461025
Joint swelling 3520.85 11.34 9906 1020131 278740 78435611
Treatment failure 3327.36 11.34 7016 1023021 163470 78550881
Arthralgia 3164.24 11.34 15170 1014867 556633 78157718
Completed suicide 2857.57 11.34 66 1029971 245701 78468650
Death 2820.12 11.34 1937 1028100 564577 78149774
Drug hypersensitivity 2722.69 11.34 9268 1020769 289648 78424703
Synovitis 2266.61 11.34 5597 1024440 145137 78569214
Rheumatoid arthritis 2249.73 11.34 6853 1023184 201617 78512734
Therapeutic product effect incomplete 2054.31 11.34 5188 1024849 136457 78577894
Musculoskeletal stiffness 1900.62 11.34 5767 1024270 169241 78545110
Contraindicated product administered 1722.28 11.34 5204 1024833 152334 78562017
Lymphoproliferative disorder 1707.24 11.34 1004 1029033 4611 78709740
Drug abuse 1636.94 11.34 121 1029916 162570 78551781
Therapeutic product effect decreased 1605.21 11.34 5211 1024826 158652 78555699
Psoriasis 1477.40 11.34 3449 1026588 86138 78628213
Arthropathy 1409.73 11.34 5258 1024779 171853 78542498
Hypotension 1405.72 11.34 2198 1027839 438119 78276232
Acute kidney injury 1271.52 11.34 3037 1027000 516367 78197984
Psoriatic arthropathy 1237.25 11.34 2958 1027079 75041 78639310
Constipation 1208.27 11.34 1125 1028912 281925 78432426
Dyspnoea 1182.71 11.34 6384 1023653 850641 77863710
Pain 1139.45 11.34 13981 1016056 689821 78024530
Arthritis 1125.93 11.34 3655 1026382 111225 78603126
Hyponatraemia 1019.69 11.34 511 1029526 177337 78537014
Dehydration 979.37 11.34 1056 1028981 247131 78467220
Intentional overdose 969.61 11.34 115 1029922 105845 78608506
Liver function test increased 955.17 11.34 1787 1028250 37986 78676365
Hyperkalaemia 947.39 11.34 167 1029870 114231 78600120
Cardiac arrest 946.00 11.34 522 1029515 171574 78542777
Bradycardia 944.17 11.34 288 1029749 135269 78579082
Rhabdomyolysis 872.91 11.34 142 1029895 102989 78611362
Somnolence 848.59 11.34 1105 1028932 237876 78476475
Pancytopenia 844.76 11.34 4304 1025733 161441 78552910
Alopecia 824.64 11.34 5464 1024573 225891 78488460
Anaemia 804.30 11.34 2995 1027042 442020 78272331
C-reactive protein abnormal 803.48 11.34 1868 1028169 46499 78667852
C-reactive protein increased 783.08 11.34 3524 1026513 125503 78588848
Red blood cell sedimentation rate increased 781.50 11.34 1791 1028246 44151 78670200
Mucosal inflammation 779.77 11.34 2448 1027589 73132 78641219
Mouth ulceration 769.48 11.34 1599 1028438 36795 78677556
Drug interaction 759.50 11.34 2780 1027257 412403 78301948
Acute graft versus host disease 750.12 11.34 785 1029252 9382 78704969
Electrocardiogram QT prolonged 743.93 11.34 134 1029903 90252 78624099
Cardio-respiratory arrest 740.48 11.34 239 1029798 108271 78606080
Dizziness 730.30 11.34 3910 1026127 522531 78191820
Red blood cell sedimentation rate abnormal 724.32 11.34 1108 1028929 19855 78694496
Cardiac failure congestive 718.13 11.34 478 1029559 141924 78572427
Overdose 711.86 11.34 797 1029240 183409 78530942
Hepatic enzyme increased 696.59 11.34 4388 1025649 178222 78536129
Pain in extremity 677.25 11.34 7443 1022594 357095 78357256
Condition aggravated 673.39 11.34 9630 1020407 491494 78222857
International normalised ratio increased 671.02 11.34 138 1029899 84583 78629768
Swelling 659.55 11.34 4926 1025111 211785 78502566
Syncope 654.23 11.34 813 1029224 178636 78535715
Inflammation 636.49 11.34 2649 1027388 91104 78623247
Infection 629.16 11.34 5300 1024737 236412 78477939
Hypoglycaemia 619.07 11.34 268 1029769 101326 78613025
Toxicity to various agents 607.10 11.34 3090 1026947 418450 78295901
Stomatitis 598.97 11.34 3589 1026448 143168 78571183
Fall 592.63 11.34 3778 1026259 483851 78230500
Peripheral swelling 587.41 11.34 5688 1024349 263929 78450422
Leukoencephalopathy 584.60 11.34 612 1029425 7317 78707034
Depressed level of consciousness 584.12 11.34 258 1029779 96394 78617957
Agitation 582.72 11.34 279 1029758 99436 78614915
Gastrointestinal disorder 567.86 11.34 3094 1026943 119111 78595240
Malignant neoplasm progression 561.66 11.34 556 1029481 135434 78578917
Suicide attempt 559.94 11.34 186 1029851 82746 78631605
Hallucination 558.82 11.34 204 1029833 85541 78628810
Confusional state 553.39 11.34 2172 1027865 315825 78398526
Injection site pain 547.66 11.34 3203 1026834 126635 78587716
Decreased appetite 546.14 11.34 2419 1027618 339999 78374352
Tremor 543.52 11.34 847 1029190 169236 78545115
Hypokalaemia 540.42 11.34 638 1029399 143402 78570949
Sedation 535.14 11.34 34 1030003 51861 78662490
Osteoarthritis 529.08 11.34 2384 1027653 84925 78629426
Pneumocystis jirovecii pneumonia 526.22 11.34 1243 1028794 31265 78683086
Abdominal discomfort 524.86 11.34 5246 1024791 245481 78468870
Chronic graft versus host disease 524.46 11.34 537 1029500 6244 78708107
Loss of personal independence in daily activities 521.76 11.34 2663 1027374 99917 78614434
Diffuse large B-cell lymphoma 514.29 11.34 707 1029330 11442 78702909
Nasopharyngitis 514.17 11.34 5276 1024761 248605 78465746
Atrial fibrillation 505.50 11.34 1129 1028908 196757 78517594
Joint stiffness 502.40 11.34 1408 1028629 39422 78674929
Lactic acidosis 499.80 11.34 144 1029893 70215 78644136
Metabolic acidosis 494.47 11.34 223 1029814 82306 78632045
Gastrointestinal haemorrhage 490.95 11.34 716 1029321 147003 78567348
Coma 489.90 11.34 351 1029686 100298 78614053
Bone erosion 475.57 11.34 839 1029198 17008 78697343
Diarrhoea 467.72 11.34 8286 1021751 872203 77842148
Multiple sclerosis relapse 466.69 11.34 35 1030002 46498 78667853
Asthenia 461.35 11.34 4305 1025732 507384 78206967
Epstein-Barr virus associated lymphoproliferative disorder 460.63 11.34 375 1029662 3157 78711194
Hand deformity 457.38 11.34 2593 1027444 101326 78613025
Mobility decreased 448.46 11.34 2908 1027129 119267 78595084
Rheumatoid nodule 443.16 11.34 803 1029234 16635 78697716
Respiratory arrest 438.97 11.34 102 1029935 57448 78656903
Drug reaction with eosinophilia and systemic symptoms 437.37 11.34 142 1029895 64102 78650249
Nodule 427.59 11.34 929 1029108 22065 78692286
Tachycardia 422.23 11.34 1054 1028983 176714 78537637
Rheumatoid factor positive 420.41 11.34 1709 1028328 58130 78656221
Epstein Barr virus positive mucocutaneous ulcer 418.35 11.34 208 1029829 627 78713724
Oedema peripheral 417.48 11.34 1757 1028280 250531 78463820
Tuberculosis 417.34 11.34 724 1029313 14474 78699877
Orthostatic hypotension 413.85 11.34 107 1029930 56057 78658294
Therapeutic response decreased 408.40 11.34 1830 1028207 65023 78649328
Epstein-Barr virus infection 405.37 11.34 694 1029343 13722 78700629
Haemoglobin decreased 400.45 11.34 1495 1028542 220624 78493727
Drug clearance decreased 400.06 11.34 337 1029700 2990 78711361
Blood glucose increased 387.22 11.34 552 1029485 114423 78599928
Cardiac failure 386.78 11.34 894 1029143 153948 78560403
Product use issue 386.60 11.34 4279 1025758 205543 78508808
Loss of consciousness 382.51 11.34 1017 1029020 166926 78547425
Ankylosing spondylitis 381.28 11.34 616 1029421 11589 78702762
Serotonin syndrome 380.94 11.34 62 1029975 44965 78669386
Off label use 375.58 11.34 14788 1015249 892427 77821924
Foot deformity 375.06 11.34 907 1029130 23167 78691184
Sopor 371.62 11.34 12 1030025 32998 78681353
Anxiety 371.42 11.34 1797 1028240 246715 78467636
Balance disorder 369.53 11.34 439 1029598 98418 78615933
Herpes zoster 369.17 11.34 2260 1027777 90823 78623528
Acute graft versus host disease in skin 358.35 11.34 468 1029569 7190 78707161
Systemic lupus erythematosus 352.56 11.34 2726 1027311 118423 78595928
Platelet count decreased 349.68 11.34 1312 1028725 193352 78520999
Angiocentric lymphoma 347.92 11.34 189 1029848 720 78713631
Aggression 340.99 11.34 116 1029921 50842 78663509
Sinusitis 339.35 11.34 3941 1026096 191560 78522791
Pulmonary fibrosis 331.70 11.34 1287 1028750 42825 78671526
Chest pain 330.27 11.34 2211 1027826 280093 78434258
Hyperhidrosis 324.44 11.34 945 1029092 150547 78563804
Pneumonia aspiration 322.65 11.34 236 1029801 66731 78647620
Seizure 321.07 11.34 1301 1028736 187533 78526818
Hospitalisation 320.72 11.34 449 1029588 93787 78620564
Unresponsive to stimuli 315.48 11.34 163 1029874 55625 78658726
Myelopathy 314.02 11.34 342 1029695 4291 78710060
Neuroleptic malignant syndrome 310.31 11.34 10 1030027 27549 78686802
Musculoskeletal pain 308.37 11.34 2322 1027715 100032 78614319
Hypoxia 307.50 11.34 538 1029499 102705 78611646
Blood creatine phosphokinase increased 305.52 11.34 243 1029794 65847 78648504
Intentional self-injury 299.45 11.34 34 1030003 32385 78681966
Grip strength decreased 298.92 11.34 784 1029253 21085 78693266
Hypomagnesaemia 298.28 11.34 116 1029921 46795 78667556
Posterior reversible encephalopathy syndrome 296.90 11.34 879 1029158 25402 78688949
Cognitive disorder 296.65 11.34 279 1029758 69647 78644704
Graft versus host disease 296.58 11.34 622 1029415 14404 78699947
Device expulsion 296.24 11.34 8 1030029 25853 78688498
Joint range of motion decreased 295.70 11.34 1025 1029012 32257 78682094
Injection site bruising 294.34 11.34 1179 1028858 39823 78674528
Acute myocardial infarction 291.23 11.34 339 1029698 76697 78637654
Knee arthroplasty 290.25 11.34 1218 1028819 42030 78672321
Lymphoma 289.52 11.34 674 1029363 16786 78697565
Injection site erythema 289.14 11.34 1865 1028172 76332 78638019
Injection site reaction 284.59 11.34 1431 1028606 53354 78660997
Plasma cell myeloma 281.82 11.34 169 1029868 53090 78661261
Drug withdrawal syndrome 280.21 11.34 54 1029983 34664 78679687
Vomiting 277.45 11.34 6518 1023519 659310 78055041
Blood creatinine increased 275.86 11.34 1049 1028988 154008 78560343
Cerebrovascular accident 274.08 11.34 1054 1028983 154238 78560113
Angioedema 272.23 11.34 349 1029688 75686 78638665
Restlessness 270.17 11.34 131 1029906 46361 78667990
Anti-cyclic citrullinated peptide antibody positive 268.05 11.34 1917 1028120 81226 78633125
Finger deformity 265.19 11.34 400 1029637 7074 78707277
Fluid retention 265.18 11.34 306 1029731 69503 78644848
Musculoskeletal disorder 261.25 11.34 737 1029300 20711 78693640
Respiratory depression 260.24 11.34 27 1030010 27603 78686748
Uveitis 259.94 11.34 632 1029405 16198 78698153
Histoplasmosis disseminated 259.85 11.34 227 1029810 2126 78712225
Joint effusion 259.82 11.34 659 1029378 17355 78696996
Intentional product misuse 258.68 11.34 524 1029513 94641 78619710
Myocardial infarction 257.04 11.34 1363 1028674 182766 78531585
Lower respiratory tract infection 254.41 11.34 2671 1027366 126549 78587802
Pulmonary tuberculosis 253.96 11.34 403 1029634 7462 78706889
Arthritis bacterial 252.13 11.34 437 1029600 8729 78705622
Coronary artery disease 251.96 11.34 284 1029753 65190 78649161
Suicidal ideation 251.61 11.34 372 1029665 75968 78638383
Melaena 248.96 11.34 251 1029786 60639 78653712
Hypersensitivity 247.99 11.34 4761 1025276 257478 78456873
Abnormal behaviour 247.02 11.34 81 1029956 36340 78678011
Cardiogenic shock 243.71 11.34 118 1029919 41796 78672555
Hyperglycaemia 241.44 11.34 333 1029704 70002 78644349
Tuberculin test positive 238.74 11.34 256 1029781 3152 78711199
Disease progression 238.68 11.34 1399 1028638 182963 78531388
Pulmonary embolism 238.29 11.34 1273 1028764 170381 78543970
Blood urea increased 237.57 11.34 170 1029867 48620 78665731
Bone marrow failure 236.58 11.34 1293 1028744 49814 78664537
Dactylitis 236.54 11.34 231 1029806 2526 78711825
Ventricular tachycardia 236.41 11.34 123 1029914 41812 78672539
Basal cell carcinoma 235.71 11.34 1033 1029004 36342 78678009
Blood calcium decreased 235.60 11.34 60 1029977 31759 78682592
Hallucination, visual 232.39 11.34 67 1029970 32662 78681689
Disorientation 231.15 11.34 282 1029755 62494 78651857
Product dose omission issue 230.18 11.34 2065 1027972 245472 78468879
Pemphigus 229.42 11.34 2127 1027910 97455 78616896
Chest discomfort 228.39 11.34 961 1029076 137083 78577268
Skin ulcer 227.59 11.34 1335 1028702 52815 78661536
Mental status changes 226.87 11.34 320 1029717 66639 78647712
Myalgia 225.03 11.34 1438 1028599 184203 78530148
Product use in unapproved indication 224.12 11.34 4508 1025529 245851 78468500
Pulmonary oedema 221.55 11.34 508 1029529 87746 78626605
Urinary retention 220.80 11.34 243 1029794 56387 78657964
White blood cell count decreased 218.39 11.34 1478 1028559 186810 78527541
Polyarthritis 217.81 11.34 485 1029552 11717 78702634
Injection site pruritus 217.18 11.34 1101 1028936 41182 78673169
Impaired healing 217.13 11.34 1902 1028135 85753 78628598
Delirium 216.61 11.34 482 1029555 84145 78630206
Tenosynovitis 216.05 11.34 561 1029476 14993 78699358
Dyspnoea exertional 213.93 11.34 507 1029530 86566 78627785
Sinus bradycardia 210.82 11.34 36 1030001 25211 78689140
Vision blurred 210.04 11.34 684 1029353 105214 78609137
Psychotic disorder 209.92 11.34 138 1029899 41264 78673087
Diabetic ketoacidosis 209.42 11.34 89 1029948 34033 78680318
Osteoporosis 208.32 11.34 1304 1028733 52808 78661543
Venoocclusive liver disease 208.02 11.34 466 1029571 11305 78703046
Renal failure 205.95 11.34 1634 1028403 199334 78515017
Disability 202.40 11.34 582 1029455 16538 78697813
Dysgeusia 202.04 11.34 265 1029772 56912 78657439
Palpitations 201.74 11.34 894 1029143 125716 78588635
Dyskinesia 201.49 11.34 169 1029868 44604 78669747
Poisoning deliberate 201.31 11.34 10 1030027 18818 78695533
Myoclonus 201.29 11.34 54 1029983 27606 78686745
Wheezing 199.33 11.34 802 1029235 115862 78598489
Juvenile idiopathic arthritis 198.32 11.34 275 1029762 4488 78709863
Blood potassium decreased 197.96 11.34 185 1029852 46327 78668024
Immunosuppression 196.90 11.34 480 1029557 12323 78702028
Haematotoxicity 194.65 11.34 539 1029498 14980 78699371
Flushing 194.51 11.34 543 1029494 87725 78626626
Fibromyalgia 193.95 11.34 1460 1028577 62880 78651471
Extrapyramidal disorder 192.35 11.34 31 1030006 22648 78691703
Blood pressure decreased 192.08 11.34 650 1029387 98816 78615535
Disturbance in attention 191.52 11.34 224 1029813 50577 78663774
Diverticulitis 190.14 11.34 1128 1028909 44808 78669543
Torsade de pointes 189.53 11.34 16 1030021 19296 78695055
Febrile bone marrow aplasia 188.50 11.34 477 1029560 12543 78701808
Pulmonary hypertension 186.70 11.34 207 1029830 47873 78666478
Hypervolaemia 185.01 11.34 167 1029870 42523 78671828
Arrhythmia 184.51 11.34 317 1029720 60955 78653396
Upper gastrointestinal haemorrhage 184.01 11.34 158 1029879 41222 78673129
Joint destruction 183.65 11.34 298 1029739 5627 78708724
Neurotoxicity 183.64 11.34 870 1029167 31648 78682703
Haemophagocytic lymphohistiocytosis 183.21 11.34 660 1029377 21177 78693174
Exposure during pregnancy 179.29 11.34 685 1029352 100447 78613904
Withdrawal syndrome 178.15 11.34 62 1029975 26792 78687559
Injection site swelling 177.83 11.34 1130 1028907 46002 78668349
Miosis 176.81 11.34 6 1030031 15783 78698568
Hypocalcaemia 176.79 11.34 231 1029806 49693 78664658
Neuropathy peripheral 176.15 11.34 1085 1028952 140220 78574131
Poisoning 175.31 11.34 54 1029983 25218 78689133
Blood alkaline phosphatase increased 175.18 11.34 348 1029689 63316 78651035
Neutrophil count decreased 174.71 11.34 624 1029413 93335 78621016
Rash maculo-papular 171.74 11.34 287 1029750 55791 78658560
Febrile neutropenia 171.72 11.34 4050 1025987 226949 78487402
Graft versus host disease in skin 171.58 11.34 293 1029744 5780 78708571
Visceral leishmaniasis 169.60 11.34 130 1029907 993 78713358
Breast cancer 169.56 11.34 874 1029163 32907 78681444
Graft versus host disease in gastrointestinal tract 168.29 11.34 298 1029739 6058 78708293
Pericarditis 168.29 11.34 2073 1027964 102163 78612188
Ventricular fibrillation 167.94 11.34 102 1029935 31824 78682527
Blood sodium decreased 167.04 11.34 112 1029925 33143 78681208
Glossodynia 166.79 11.34 2055 1027982 101282 78613069
Dystonia 165.03 11.34 37 1030000 21362 78692989
Blood pressure fluctuation 164.74 11.34 1454 1028583 65691 78648660
Enthesopathy 163.62 11.34 421 1029616 11187 78703164
Inappropriate schedule of product administration 163.42 11.34 2529 1027508 131099 78583252
Infusion related reaction 162.78 11.34 4009 1026028 226228 78488123
Circulatory collapse 161.28 11.34 149 1029888 37519 78676832
Acute graft versus host disease in intestine 155.96 11.34 225 1029812 3816 78710535
Acute respiratory failure 155.76 11.34 335 1029702 59206 78655145
Cerebral haemorrhage 154.64 11.34 320 1029717 57353 78656998
Delusion 154.15 11.34 37 1030000 20386 78693965
Fear of injection 154.09 11.34 315 1029722 7159 78707192
Mucocutaneous ulceration 154.04 11.34 84 1029953 323 78714028
Haematemesis 153.19 11.34 275 1029762 51989 78662362
Premature delivery 152.58 11.34 56 1029981 23411 78690940
Infective pulmonary exacerbation of cystic fibrosis 150.97 11.34 3 1030034 12848 78701503
Abdominal distension 150.54 11.34 916 1029121 118734 78595617
Palmar-plantar erythrodysaesthesia syndrome 150.42 11.34 124 1029913 33010 78681341
Wound 150.27 11.34 2220 1027817 113959 78600392
Lethargy 149.73 11.34 542 1029495 80750 78633601
Full blood count decreased 149.20 11.34 80 1029957 26739 78687612
Creatinine renal clearance decreased 148.27 11.34 32 1030005 18970 78695381
Device dislocation 148.13 11.34 75 1029962 25895 78688456
Product quality issue 148.00 11.34 132 1029905 33808 78680543
Disseminated tuberculosis 147.17 11.34 223 1029814 3960 78710391
Pulmonary mass 146.99 11.34 753 1029284 28281 78686070
Latent tuberculosis 146.26 11.34 198 1029839 3155 78711196
Malignant melanoma 146.03 11.34 471 1029566 14270 78700081
Impaired work ability 145.32 11.34 571 1029466 19110 78695241
Gastrooesophageal reflux disease 145.22 11.34 772 1029265 103474 78610877
Hepatic encephalopathy 145.19 11.34 65 1029972 24101 78690250
Muscle twitching 145.07 11.34 69 1029968 24695 78689656
Lymphocyte count decreased 144.83 11.34 242 1029795 47047 78667304
Right ventricular failure 144.66 11.34 61 1029976 23436 78690915
Muscle rigidity 144.33 11.34 39 1029998 19843 78694508
Mania 144.02 11.34 30 1030007 18230 78696121
Epidermal necrosis 143.23 11.34 134 1029903 1383 78712968
Synovial cyst 141.83 11.34 365 1029672 9700 78704651
Eosinophilia 141.72 11.34 229 1029808 45116 78669235
Chronic obstructive pulmonary disease 141.65 11.34 594 1029443 84825 78629526
Mycobacterium tuberculosis complex test positive 140.66 11.34 177 1029860 2615 78711736
Presyncope 140.26 11.34 195 1029842 40859 78673492
Atrial flutter 139.93 11.34 52 1029985 21573 78692778
Anhedonia 139.17 11.34 15 1030022 14883 78699468
Fine motor skill dysfunction 139.06 11.34 249 1029788 5108 78709243
Acute lymphocytic leukaemia recurrent 138.88 11.34 232 1029805 4492 78709859
Ill-defined disorder 138.82 11.34 1381 1028656 64494 78649857
Aphthous ulcer 137.91 11.34 506 1029531 16383 78697968
Ascites 137.05 11.34 507 1029530 75055 78639296
Rheumatoid lung 136.36 11.34 217 1029820 4028 78710323
Cutaneous leishmaniasis 136.08 11.34 71 1029966 244 78714107
Akathisia 135.76 11.34 9 1030028 13250 78701101
Hypophosphataemia 135.54 11.34 44 1029993 19869 78694482
B-cell lymphoma 135.37 11.34 268 1029769 5947 78708404
Asthma 135.31 11.34 1105 1028932 133990 78580361
Interstitial lung disease 134.98 11.34 2124 1027913 110476 78603875
Chronic kidney disease 134.86 11.34 422 1029615 65732 78648619
Hepatotoxicity 133.81 11.34 1127 1028910 50225 78664126
Hallucination, auditory 133.49 11.34 50 1029987 20643 78693708
Tubulointerstitial nephritis 133.25 11.34 179 1029858 38056 78676295
Altered state of consciousness 132.60 11.34 226 1029811 43596 78670755
Jaundice 132.34 11.34 309 1029728 53040 78661311
Lung disorder 131.71 11.34 1606 1028431 78951 78635400
Irritability 131.22 11.34 205 1029832 40939 78673412
Haematuria 130.74 11.34 453 1029584 68383 78645968
Haemoptysis 130.54 11.34 335 1029702 55664 78658687
Paranoia 130.40 11.34 44 1029993 19388 78694963
Deep vein thrombosis 129.51 11.34 971 1029066 119948 78594403
Parkinsonism 129.26 11.34 28 1030009 16556 78697795
Sensitivity to weather change 128.37 11.34 306 1029731 7741 78706610
Pustular psoriasis 128.12 11.34 226 1029811 4580 78709771
Stevens-Johnson syndrome 127.93 11.34 192 1029845 38974 78675377
Discomfort 127.37 11.34 2306 1027731 123311 78591040
Haematoma 126.54 11.34 306 1029731 51889 78662462
Muscle spasms 125.52 11.34 1548 1028489 173182 78541169
Sinus tachycardia 125.40 11.34 176 1029861 36732 78677619
Joint injury 124.92 11.34 762 1029275 30573 78683778
Nightmare 124.73 11.34 91 1029946 25770 78688581
Electrolyte imbalance 124.30 11.34 129 1029908 30752 78683599
Head injury 124.19 11.34 181 1029856 37188 78677163
Oral herpes 123.31 11.34 689 1029348 26765 78687586
Injection site haemorrhage 122.90 11.34 696 1029341 27174 78687177
Hypofibrinogenaemia 122.32 11.34 140 1029897 1862 78712489
Substance abuse 121.53 11.34 3 1030034 10523 78703828
Hypothermia 120.58 11.34 72 1029965 22674 78691677
Cataract 120.29 11.34 1280 1028757 60840 78653511
Injection site warmth 119.55 11.34 442 1029595 14365 78699986
Sacroiliitis 119.35 11.34 191 1029846 3563 78710788
Cytokine release syndrome 119.01 11.34 175 1029862 35823 78678528
Panniculitis 118.70 11.34 391 1029646 11980 78702371
Dysphagia 118.69 11.34 1007 1029030 121129 78593222
Intentional product use issue 117.93 11.34 2683 1027354 149429 78564922
Neoplasm progression 117.55 11.34 313 1029724 51369 78662982
Troponin increased 116.92 11.34 51 1029986 19204 78695147
Renal impairment 116.31 11.34 1390 1028647 156393 78557958
Haematocrit decreased 116.10 11.34 404 1029633 60908 78653443
Leukocytosis 115.75 11.34 242 1029795 43213 78671138
Respiratory failure 115.62 11.34 1642 1028395 179269 78535082
Hospice care 115.33 11.34 4 1030033 10320 78704031
Ulcer 115.17 11.34 722 1029315 29250 78685101
Histoplasmosis 114.51 11.34 147 1029890 2218 78712133
Kidney transplant rejection 114.36 11.34 4 1030033 10242 78704109
Demyelination 114.14 11.34 292 1029745 7731 78706620
Chronic graft versus host disease in skin 113.38 11.34 120 1029917 1454 78712897
Contraindication to medical treatment 113.12 11.34 110 1029927 1196 78713155
Deformity 113.03 11.34 326 1029711 9279 78705072
Subdural haematoma 112.79 11.34 144 1029893 31290 78683061
Wrist deformity 112.74 11.34 138 1029899 1979 78712372
Transient ischaemic attack 112.53 11.34 329 1029708 52366 78661985
Drug ineffective for unapproved indication 112.28 11.34 1083 1028954 50155 78664196
Hepatic steatosis 111.83 11.34 853 1029184 36885 78677466
Cytomegalovirus chorioretinitis 111.55 11.34 230 1029807 5260 78709091
Oedema 111.28 11.34 997 1029040 118583 78595768
Skin plaque 110.71 11.34 348 1029689 10397 78703954
Lip swelling 110.52 11.34 226 1029811 40685 78673666
Oropharyngeal pain 109.29 11.34 2003 1028034 107350 78607001
Joint arthroplasty 107.85 11.34 154 1029883 2586 78711765
Abdominal pain 107.62 11.34 4030 1026007 385539 78328812
Pallor 107.31 11.34 312 1029725 49750 78664601
Heparin-induced thrombocytopenia 107.30 11.34 4 1030033 9678 78704673
Hip arthroplasty 106.40 11.34 809 1029228 34947 78679404
Depression 105.94 11.34 2067 1027970 214723 78499628
Cystitis haemorrhagic 105.72 11.34 309 1029728 8863 78705488
Sleep disorder due to general medical condition, insomnia type 105.70 11.34 941 1029096 42615 78671736
Pulmonary arterial hypertension 104.86 11.34 127 1029910 28239 78686112
Arthrodesis 104.78 11.34 142 1029895 2265 78712086
Dysarthria 104.38 11.34 483 1029554 67139 78647212
Labelled drug-drug interaction medication error 104.13 11.34 122 1029915 27528 78686823
Atrioventricular block first degree 103.88 11.34 18 1030019 12473 78701878
Pulmonary toxicity 103.85 11.34 385 1029652 12529 78701822
Helicobacter infection 103.47 11.34 1365 1028672 68339 78646012
Cardiac disorder 102.50 11.34 468 1029569 65289 78649062
Caesarean section 102.21 11.34 19 1030018 12516 78701835
Hyperthyroidism 102.20 11.34 82 1029955 22127 78692224
Electrocardiogram QRS complex prolonged 100.96 11.34 11 1030026 10822 78703529
Blood glucose decreased 100.69 11.34 114 1029923 26120 78688231
Schizophrenia 100.12 11.34 37 1030000 15403 78698948
Bronchospasm 99.88 11.34 104 1029933 24755 78689596
Drug tolerance decreased 99.46 11.34 381 1029656 12597 78701754
Hypothyroidism 99.35 11.34 345 1029692 52047 78662304
Haemorrhage 99.33 11.34 728 1029309 90390 78623961
Elbow deformity 99.32 11.34 111 1029926 1436 78712915
Full blood count abnormal 99.13 11.34 236 1029801 40238 78674113
Transfusion 99.10 11.34 78 1029959 21252 78693099
Dysuria 99 11.34 332 1029705 50619 78663732
Hypovolaemia 98.08 11.34 53 1029984 17638 78696713
Blood potassium increased 98.07 11.34 141 1029896 29134 78685217
Neck pain 97.84 11.34 1442 1028595 73975 78640376
Blood bilirubin increased 97.60 11.34 481 1029556 65751 78648600
Salivary hypersecretion 97.58 11.34 31 1030006 14193 78700158
Swollen tongue 96.68 11.34 258 1029779 42312 78672039
Skin lesion 96.44 11.34 894 1029143 40950 78673401
Speech disorder 95.69 11.34 370 1029667 54075 78660276
Atrioventricular block 95.61 11.34 31 1030006 14010 78700341
Ventricular extrasystoles 95.47 11.34 69 1029968 19635 78694716
Epstein-Barr virus infection reactivation 95.40 11.34 120 1029917 1772 78712579
Mycobacterium marinum infection 95.31 11.34 65 1029972 404 78713947
Emotional distress 94.79 11.34 237 1029800 39732 78674619
Blood loss anaemia 94.18 11.34 41 1029996 15457 78698894
Folliculitis 93.99 11.34 1112 1028925 54268 78660083
Hepatic enzyme abnormal 93.77 11.34 267 1029770 7543 78706808
Dry skin 92.77 11.34 507 1029530 67488 78646863
Lupus-like syndrome 92.75 11.34 390 1029647 13467 78700884
Supraventricular tachycardia 92.41 11.34 83 1029954 21187 78693164
Chromaturia 92.32 11.34 118 1029919 25628 78688723
Blood magnesium decreased 92.23 11.34 49 1029988 16463 78697888
Chills 92.20 11.34 1484 1028553 158750 78555601
Acidosis 92.15 11.34 72 1029965 19690 78694661
Myocardial ischaemia 91.46 11.34 117 1029920 25402 78688949
Liver disorder 90.97 11.34 1377 1028660 71040 78643311
Neuroendocrine carcinoma of the skin 90.93 11.34 98 1029939 1214 78713137
Rheumatoid factor negative 90.90 11.34 93 1029944 1080 78713271
Aspiration 90.81 11.34 76 1029961 20082 78694269
Tardive dyskinesia 90.66 11.34 14 1030023 10557 78703794
Spinal stenosis 90.26 11.34 424 1029613 15367 78698984
Ejection fraction decreased 89.23 11.34 196 1029841 34381 78679970
Urinary tract infection 88.46 11.34 2785 1027252 271727 78442624
Leukaemia recurrent 88.00 11.34 141 1029896 2633 78711718
Mydriasis 87.83 11.34 60 1029977 17583 78696768
Obstructive airways disorder 87.37 11.34 171 1029866 31288 78683063
Electrocardiogram abnormal 87.29 11.34 54 1029983 16683 78697668
Fear 87.19 11.34 93 1029944 21893 78692458
Foot operation 87.16 11.34 214 1029823 5519 78708832
Paraesthesia 86.79 11.34 1679 1028358 174644 78539707
Shock 85.82 11.34 282 1029755 43266 78671085
Lymph node tuberculosis 85.21 11.34 84 1029953 930 78713421
General physical health deterioration 84.95 11.34 2808 1027229 272430 78441921
Spondyloarthropathy 84.91 11.34 85 1029952 960 78713391
Atrioventricular block complete 84.69 11.34 55 1029982 16555 78697796
Rectal haemorrhage 84.42 11.34 607 1029430 75693 78638658
Skin erosion 84.25 11.34 181 1029856 4264 78710087
Exposure to toxic agent 83.59 11.34 10 1030027 9148 78705203
Paraesthesia oral 82.97 11.34 85 1029952 20386 78693965
Heart rate increased 82.77 11.34 1080 1028957 119644 78594707
Cyanosis 82.68 11.34 123 1029914 25059 78689292
Thrombocytopenia 82.38 11.34 2704 1027333 262555 78451796
Depressed mood 82.31 11.34 334 1029703 48146 78666205
Tricuspid valve incompetence 82.01 11.34 80 1029957 19632 78694719
Irritable bowel syndrome 81.49 11.34 1192 1028845 61049 78653302
End stage renal disease 81.43 11.34 28 1030009 12192 78702159
Faecal calprotectin increased 81.25 11.34 204 1029833 5337 78709014
Red blood cell count decreased 81.15 11.34 424 1029613 57089 78657262
Localised infection 80.74 11.34 791 1029246 36784 78677567
Transplant rejection 80.73 11.34 79 1029958 19358 78694993
Insomnia 80.03 11.34 2483 1027554 242687 78471664
Product substitution issue 79.97 11.34 86 1029951 20170 78694181
Non-alcoholic steatohepatitis 79.76 11.34 121 1029916 2151 78712200
Toxic epidermal necrolysis 79.61 11.34 301 1029736 44280 78670071
Granuloma skin 79.28 11.34 280 1029757 8894 78705457
Peritonitis bacterial 79.09 11.34 14 1030023 9553 78704798
Tenderness 79.01 11.34 550 1029487 23092 78691259
Cytomegalovirus infection reactivation 78.77 11.34 270 1029767 8446 78705905
Disease recurrence 78.11 11.34 893 1029144 43216 78671135
Neutrophil count increased 78.04 11.34 164 1029873 29232 78685119
Sarcoidosis 77.80 11.34 261 1029776 8074 78706277
Psychomotor hyperactivity 77.79 11.34 62 1029975 16787 78697564
Muscle injury 77.58 11.34 964 1029073 47597 78666754
Respiratory acidosis 77.56 11.34 24 1030013 11176 78703175
Haemorrhage intracranial 77.50 11.34 137 1029900 26056 78688295
Duodenal ulcer perforation 77.08 11.34 1243 1028794 64968 78649383
Shoulder arthroplasty 76.95 11.34 146 1029891 3136 78711215
Acute generalised exanthematous pustulosis 76.56 11.34 66 1029971 17188 78697163
Urinary incontinence 76.48 11.34 271 1029766 40638 78673713
Infusion site pain 76.38 11.34 44 1029993 14132 78700219
Treatment noncompliance 76.20 11.34 381 1029656 51887 78662464
Inflammatory marker increased 75.61 11.34 307 1029730 10433 78703918
Bradyphrenia 75.13 11.34 22 1030015 10618 78703733
Hypomania 74.72 11.34 6 1030031 7538 78706813
Anaphylactic shock 74.51 11.34 228 1029809 35768 78678583
Faeces discoloured 74.43 11.34 166 1029871 28961 78685390
Status epilepticus 74.06 11.34 131 1029906 24910 78689441
Therapy non-responder 73.99 11.34 1636 1028401 90669 78623682
Glycosylated haemoglobin increased 73.59 11.34 84 1029953 19176 78695175
Seronegative arthritis 73.32 11.34 177 1029860 4515 78709836
Ankle deformity 73.27 11.34 66 1029971 646 78713705
Cerebral infarction 73.03 11.34 322 1029715 45354 78668997
Angioimmunoblastic T-cell lymphoma 72.91 11.34 55 1029982 409 78713942
Faecaloma 72.84 11.34 29 1030008 11535 78702816
Cholecystitis chronic 72.72 11.34 19 1030018 9887 78704464
Mycobacterium chelonae infection 72.71 11.34 121 1029916 2335 78712016
Abscess 72.67 11.34 527 1029510 22424 78691927
Respiratory distress 72.63 11.34 448 1029589 57891 78656460
Skin cancer 72.63 11.34 385 1029652 14655 78699696
Acute coronary syndrome 72.57 11.34 100 1029937 21033 78693318
Hepatic fibrosis 72.46 11.34 233 1029804 7047 78707304
Tachypnoea 72.29 11.34 195 1029842 31868 78682483
Venoocclusive disease 71.98 11.34 173 1029864 4400 78709951
Acute hepatic failure 71.84 11.34 178 1029859 29935 78684416
Pleurisy 71.82 11.34 297 1029740 10178 78704173
White blood cell count increased 71.75 11.34 617 1029420 74016 78640335
Arachnoiditis 71.70 11.34 68 1029969 715 78713636
Blood pressure diastolic abnormal 71.57 11.34 459 1029578 18743 78695608
Myocarditis 71.50 11.34 106 1029931 21627 78692724
Chemotherapeutic drug level increased 71.42 11.34 49 1029988 308 78714043
Bundle branch block right 71.22 11.34 28 1030009 11223 78703128
Adult T-cell lymphoma/leukaemia 71.18 11.34 48 1029989 292 78714059
Dialysis 71.10 11.34 80 1029957 18382 78695969
Angina pectoris 70.98 11.34 385 1029652 51347 78663004
Wrong technique in product usage process 70.90 11.34 611 1029426 73264 78641087
Diabetes mellitus inadequate control 70.81 11.34 128 1029909 24136 78690215
Chondropathy 70.71 11.34 121 1029916 2391 78711960
Gamma-glutamyltransferase increased 70.66 11.34 415 1029622 54265 78660086
Ischaemic stroke 70.63 11.34 207 1029830 32924 78681427
Subarachnoid haemorrhage 70.55 11.34 130 1029907 24335 78690016
Blood phosphorus increased 70.18 11.34 23 1030014 10324 78704027
Sudden death 70.04 11.34 114 1029923 22397 78691954
Hodgkin's disease 69.97 11.34 70 1029967 790 78713561
Blood pressure systolic abnormal 69.75 11.34 421 1029616 16826 78697525
Adenovirus infection 69.75 11.34 254 1029783 8193 78706158
Erythema multiforme 69.62 11.34 75 1029962 17576 78696775
Complications of transplanted kidney 69.30 11.34 3 1030034 6363 78707988
Anuria 69.20 11.34 102 1029935 20861 78693490
Cytomegalovirus infection 69.18 11.34 849 1029188 41795 78672556
Epistaxis 69.16 11.34 1018 1029019 110497 78603854
SLE arthritis 69.11 11.34 59 1029978 534 78713817
Euglycaemic diabetic ketoacidosis 69.04 11.34 5 1030032 6839 78707512
Mucosal ulceration 68.97 11.34 102 1029935 1771 78712580
Hyperlipidaemia 68.91 11.34 146 1029891 25947 78688404
Complications of bone marrow transplant 68.69 11.34 61 1029976 585 78713766
Secondary immunodeficiency 68.69 11.34 138 1029899 3096 78711255
Blood parathyroid hormone decreased 68.56 11.34 294 1029743 10242 78704109
Swelling face 68.33 11.34 589 1029448 70623 78643728
Epstein-Barr virus associated lymphoma 67.97 11.34 77 1029960 1012 78713339
Erectile dysfunction 67.65 11.34 54 1029983 14610 78699741
Blood pressure diastolic decreased 67.35 11.34 641 1029396 29575 78684776
Product administration error 67.14 11.34 200 1029837 31646 78682705
Extranodal marginal zone B-cell lymphoma (MALT type) 66.83 11.34 58 1029979 538 78713813
Epicondylitis 66.77 11.34 109 1029928 2069 78712282
Limb deformity 66.68 11.34 145 1029892 3445 78710906
Device occlusion 66.59 11.34 35 1030002 11831 78702520
Prothrombin time prolonged 66.43 11.34 72 1029965 16827 78697524
Body height below normal 66.02 11.34 105 1029932 1948 78712403
Polyuria 65.93 11.34 58 1029979 14956 78699395
Bone pain 65.84 11.34 435 1029602 55307 78659044
Catatonia 65.81 11.34 16 1030021 8740 78705611
Injury 65.74 11.34 661 1029376 76835 78637516
Granulomatous pneumonitis 65.65 11.34 30 1030007 70 78714281
Scleritis 65.59 11.34 162 1029875 4194 78710157
Systemic infection 65.58 11.34 22 1030015 9730 78704621
Bradypnoea 65.39 11.34 3 1030034 6049 78708302
Anal fistula 65.31 11.34 218 1029819 6726 78707625
Acute graft versus host disease in liver 65.04 11.34 101 1029936 1834 78712517
Pollakiuria 64.68 11.34 255 1029782 37062 78677289
Varicella zoster virus infection 64.60 11.34 163 1029874 4278 78710073
Cutaneous T-cell lymphoma 64.31 11.34 121 1029916 2582 78711769
Flatulence 64.26 11.34 308 1029729 42416 78671935
Apparent death 64.16 11.34 125 1029912 2740 78711611
Gait disturbance 63.98 11.34 3286 1026751 204220 78510131
Hypersensitivity pneumonitis 63.82 11.34 146 1029891 3593 78710758
Fungal infection 63.81 11.34 822 1029215 40926 78673425
Hypoxic-ischaemic encephalopathy 63.45 11.34 12 1030025 7808 78706543
Angina unstable 63.23 11.34 72 1029965 16455 78697896
Oral mucosa erosion 63.19 11.34 100 1029937 1847 78712504
Complication of device insertion 63.04 11.34 5 1030032 6345 78708006
Pneumonia cryptococcal 62.97 11.34 88 1029949 1447 78712904
Temperature regulation disorder 62.92 11.34 3 1030034 5850 78708501
Limb discomfort 62.71 11.34 675 1029362 32175 78682176
Rheumatoid factor increased 62.54 11.34 96 1029941 1725 78712626
Mesenteritis 62.47 11.34 45 1029992 309 78714042
Drug screen positive 62.42 11.34 4 1030033 6059 78708292
Epilepsy 62.37 11.34 293 1029744 40567 78673784
Gastric disorder 62.36 11.34 749 1029288 36684 78677667
Asphyxia 62.26 11.34 37 1030000 11683 78702668
Cardiac failure chronic 62.25 11.34 33 1030004 11102 78703249
Hepatitis B reactivation 62.17 11.34 197 1029840 5911 78708440
Mitral valve incompetence 61.97 11.34 177 1029860 28388 78685963
Lower gastrointestinal haemorrhage 61.96 11.34 70 1029967 16055 78698296
Cholestasis 61.88 11.34 406 1029631 51703 78662648
Pleural effusion 61.85 11.34 1416 1028621 143846 78570505
Drug specific antibody 61.73 11.34 117 1029920 2511 78711840
Ileus 61.70 11.34 156 1029881 26055 78688296
Medial tibial stress syndrome 61.68 11.34 33 1030004 121 78714230
Hepatic cirrhosis 61.50 11.34 706 1029331 34200 78680151
Investigation abnormal 61.45 11.34 102 1029935 1964 78712387
Oral disorder 61.36 11.34 276 1029761 9819 78704532
Activated partial thromboplastin time prolonged 61.24 11.34 56 1029981 14172 78700179
Ventricular arrhythmia 61.11 11.34 19 1030018 8821 78705530
Complication associated with device 60.87 11.34 82 1029955 17414 78696937
Drug dependence 60.69 11.34 295 1029742 40474 78673877
Lung neoplasm malignant 60.67 11.34 587 1029450 27205 78687146
Pulseless electrical activity 60.63 11.34 56 1029981 14104 78700247
Bronchitis 60.58 11.34 2159 1027878 128485 78585866
Face oedema 60.56 11.34 175 1029862 27961 78686390
Hypercapnia 60.36 11.34 20 1030017 8915 78705436
Arthritis infective 60.28 11.34 239 1029798 8032 78706319
Adverse reaction 59.91 11.34 259 1029778 9055 78705296
Uterine perforation 59.77 11.34 6 1030031 6297 78708054
Device difficult to use 59.64 11.34 51 1029986 13334 78701017
Proteinuria 59.64 11.34 217 1029820 32285 78682066
Glomerular filtration rate decreased 59.14 11.34 128 1029909 22574 78691777
Mycobacterial infection 59.07 11.34 140 1029897 3528 78710823
Pneumonia legionella 58.88 11.34 122 1029915 2800 78711551
Hepatic failure 58.86 11.34 506 1029531 60706 78653645
Mental disorder 58.76 11.34 207 1029830 31095 78683256
Surgical failure 58.64 11.34 64 1029973 805 78713546
Haemorrhagic stroke 58.50 11.34 35 1030002 11011 78703340
Immunodeficiency 58.44 11.34 481 1029556 21287 78693064
Electrocardiogram ST segment elevation 58.14 11.34 18 1030019 8379 78705972
Device leakage 58.06 11.34 34 1030003 10822 78703529
Ischaemic cardiomyopathy 57.96 11.34 14 1030023 7681 78706670
Lennox-Gastaut syndrome 57.95 11.34 36 1030001 186 78714165
Musculoskeletal deformity 57.67 11.34 85 1029952 1471 78712880
Thinking abnormal 57.60 11.34 51 1029986 13110 78701241
Drug specific antibody present 57.46 11.34 203 1029834 6449 78707902
Hyperthermia 57.39 11.34 90 1029947 17947 78696404
Colorectal cancer 57.30 11.34 20 1030017 8627 78705724
Tonsillitis 57.23 11.34 204 1029833 6510 78707841
Atypical mycobacterial infection 57.23 11.34 90 1029947 1653 78712698
Pharyngitis 57.19 11.34 489 1029548 21886 78692465
Osteopenia 57.18 11.34 420 1029617 17944 78696407
Joint dislocation 57.16 11.34 395 1029642 16544 78697807
Poor venous access 57.04 11.34 416 1029621 17733 78696618
Bone swelling 56.97 11.34 89 1029948 1625 78712726
Oxygen saturation decreased 56.91 11.34 1251 1028786 127796 78586555
Rhinitis allergic 56.83 11.34 45 1029992 12224 78702127
Squamous cell carcinoma of lung 56.82 11.34 105 1029932 2209 78712142
Failure to thrive 56.70 11.34 42 1029995 11802 78702549
Episcleritis 56.55 11.34 69 1029968 986 78713365
Foot fracture 56.51 11.34 481 1029556 21500 78692851
Aspartate aminotransferase increased 56.37 11.34 1361 1028676 137280 78577071
Oral mucosal exfoliation 56.31 11.34 82 1029955 1403 78712948
Premature labour 56.29 11.34 19 1030018 8371 78705980
Hyperreflexia 56.24 11.34 19 1030018 8366 78705985
Memory impairment 56.17 11.34 1060 1028977 110674 78603677
Pemphigoid 56.15 11.34 69 1029968 15246 78699105
Bradykinesia 56.12 11.34 17 1030020 8026 78706325
Therapeutic response shortened 55.96 11.34 374 1029663 15489 78698862
Infusion site erythema 55.96 11.34 26 1030011 9434 78704917
Osteoporotic fracture 55.90 11.34 150 1029887 4090 78710261
Disability assessment scale score increased 55.70 11.34 132 1029905 3326 78711025
Atrioventricular block second degree 55.67 11.34 13 1030024 7299 78707052
Long QT syndrome 55.62 11.34 6 1030031 5949 78708402
Immobile 55.33 11.34 207 1029830 6766 78707585
Blood pressure systolic increased 55.19 11.34 1192 1028845 65794 78648557
Engraftment syndrome 55.18 11.34 79 1029958 1330 78713021
Renal tubular necrosis 55.17 11.34 154 1029883 24885 78689466
Brain natriuretic peptide increased 54.95 11.34 23 1030014 8877 78705474
Tinnitus 54.90 11.34 341 1029696 43992 78670359
Shock haemorrhagic 54.88 11.34 110 1029927 19950 78694401
Deafness transitory 54.84 11.34 66 1029971 929 78713422
Bronchitis chronic 54.57 11.34 154 1029883 4328 78710023
Thirst 54.53 11.34 98 1029939 18521 78695830
Injection site rash 54.41 11.34 408 1029629 17546 78696805
Renal injury 54.30 11.34 84 1029953 16843 78697508
Hypophagia 54.11 11.34 353 1029684 45014 78669337
Vascular device infection 53.81 11.34 33 1030004 10243 78704108
Glaucoma 53.78 11.34 438 1029599 19323 78695028
Respiratory tract congestion 53.61 11.34 441 1029596 19513 78694838
Thrombosis 53.45 11.34 764 1029273 83336 78631015
Sleep apnoea syndrome 53.12 11.34 266 1029771 36212 78678139
Ophthalmic herpes zoster 52.84 11.34 111 1029926 2573 78711778
Somnambulism 52.83 11.34 6 1030031 5715 78708636
Pyoderma gangrenosum 52.72 11.34 145 1029892 4013 78710338
Abnormal dreams 52.68 11.34 42 1029995 11370 78702981
Bundle branch block left 52.36 11.34 43 1029994 11470 78702881
Ketoacidosis 52.33 11.34 18 1030019 7836 78706515
Spinal pain 51.98 11.34 359 1029678 15033 78699318
Amyotrophic lateral sclerosis 51.85 11.34 88 1029949 1727 78712624
Joint lock 51.84 11.34 123 1029914 3102 78711249
Cardiac failure acute 51.61 11.34 104 1029933 18825 78695526
Anger 51.47 11.34 89 1029948 17073 78697278
Hypoaesthesia oral 51.40 11.34 64 1029973 14060 78700291
Superior sagittal sinus thrombosis 51.35 11.34 66 1029971 997 78713354
Glioma 51.29 11.34 51 1029986 571 78713780
Physical disability 51.09 11.34 124 1029913 3174 78711177
Dermatitis acneiform 51.07 11.34 33 1030004 9960 78704391
Unevaluable event 51.01 11.34 465 1029572 55120 78659231
Bone cyst 50.98 11.34 127 1029910 3306 78711045
Urine output decreased 50.88 11.34 97 1029940 17925 78696426
Joint noise 50.80 11.34 139 1029898 3835 78710516
Cholelithiasis 50.78 11.34 435 1029602 52229 78662122
Myelitis 50.75 11.34 102 1029935 2289 78712062
Inappropriate antidiuretic hormone secretion 50.74 11.34 172 1029865 26141 78688210
Generalised tonic-clonic seizure 50.69 11.34 345 1029692 43565 78670786
Haemodynamic instability 50.45 11.34 92 1029945 17290 78697061
Skin necrosis 50.36 11.34 403 1029634 17684 78696667
Chronic graft versus host disease in intestine 50.24 11.34 40 1029997 325 78714026
Pancreatitis acute 49.97 11.34 405 1029632 49199 78665152
Molluscum contagiosum 49.68 11.34 45 1029992 444 78713907
Pharyngitis streptococcal 49.52 11.34 271 1029766 10443 78703908
Angioimmunoblastic T-cell lymphoma stage IV 49.42 11.34 17 1030020 10 78714341
Intervertebral disc space narrowing 49.40 11.34 84 1029953 1651 78712700
Rash 49.34 11.34 8342 1021695 570016 78144335
Inflammatory pain 49.30 11.34 64 1029973 977 78713374
Therapy change 49.22 11.34 17 1030020 7382 78706969
Temporal lobe epilepsy 49.20 11.34 43 1029994 403 78713948
Aplasia 49.19 11.34 216 1029821 7604 78706747
Hypernatraemia 49.00 11.34 69 1029968 14382 78699969
Product monitoring error 48.91 11.34 27 1030010 8879 78705472
Nephrogenic systemic fibrosis 48.83 11.34 10 1030027 6150 78708201
Clinodactyly 48.82 11.34 17 1030020 11 78714340
Human antichimeric antibody positive 48.79 11.34 81 1029956 1560 78712791
Hiccups 48.76 11.34 35 1030002 9996 78704355
Injection site urticaria 48.67 11.34 308 1029729 12518 78701833
International normalised ratio abnormal 48.66 11.34 8 1030029 5760 78708591
Retching 48.45 11.34 95 1029942 17372 78696979
Blood pressure diastolic increased 48.42 11.34 338 1029699 14204 78700147
Dementia 48.37 11.34 160 1029877 24499 78689852
Epstein-Barr virus antigen positive 48.35 11.34 24 1030013 72 78714279
Gestational diabetes 48.29 11.34 11 1030026 6282 78708069
Arteriosclerosis 48.12 11.34 102 1029935 18125 78696226
Hepatitis cholestatic 48.11 11.34 65 1029972 13787 78700564
Coma scale abnormal 48.10 11.34 26 1030011 8652 78705699
Vertigo 48.08 11.34 616 1029421 68466 78645885
Sickle cell anaemia with crisis 48.07 11.34 21 1030016 7901 78706450
Device use error 47.79 11.34 16 1030021 7085 78707266
Wrong patient received product 47.68 11.34 3 1030034 4615 78709736
Atlantoaxial instability 47.59 11.34 36 1030001 269 78714082
Leishmaniasis 47.56 11.34 40 1029997 354 78713997
Nasal ulcer 47.48 11.34 93 1029944 2047 78712304
Pleuropericarditis 47.36 11.34 42 1029995 402 78713949
Tooth infection 47.31 11.34 410 1029627 18422 78695929
Procedural pain 47.22 11.34 147 1029890 22937 78691414
Intestinal obstruction 47.22 11.34 343 1029694 42677 78671674
Acute pulmonary oedema 47.21 11.34 69 1029968 14161 78700190
Cancer pain 47.21 11.34 6 1030031 5239 78709112
Blood lactic acid increased 47.17 11.34 57 1029980 12687 78701664
Synovectomy 47.05 11.34 33 1030004 216 78714135
Hepatitis E 47.04 11.34 113 1029924 2873 78711478
Cerebral toxoplasmosis 46.87 11.34 98 1029939 2264 78712087
Dry mouth 46.75 11.34 827 1029210 87192 78627159
Spinal instability 46.71 11.34 42 1029995 410 78713941
Body temperature decreased 46.66 11.34 627 1029410 31518 78682833
Onychomycosis 46.62 11.34 221 1029816 8040 78706311
Extrapulmonary tuberculosis 46.60 11.34 40 1029997 365 78713986
Hepatosplenic T-cell lymphoma 46.38 11.34 57 1029980 821 78713530
Varicella 46.24 11.34 111 1029926 2821 78711530
Squamous cell carcinoma 46.22 11.34 353 1029684 15269 78699082
Mineral metabolism disorder 46.15 11.34 36 1030001 283 78714068
Tooth abscess 46.13 11.34 363 1029674 15847 78698504
Insurance issue 46.09 11.34 9 1030028 5724 78708627
Amylase increased 46.05 11.34 46 1029991 11163 78703188
Haemodialysis 46.05 11.34 104 1029933 18064 78696287
Neoplasm malignant 45.98 11.34 620 1029417 31190 78683161
Diffuse large B-cell lymphoma stage IV 45.73 11.34 45 1029992 497 78713854
Sleep terror 45.72 11.34 3 1030034 4455 78709896
Taste disorder 45.70 11.34 84 1029953 15739 78698612
Abscess limb 45.66 11.34 196 1029841 6831 78707520
No adverse event 45.57 11.34 287 1029750 36905 78677446
Pre-eclampsia 45.44 11.34 17 1030020 7024 78707327
Forced expiratory volume decreased 45.42 11.34 22 1030015 7792 78706559
Mood altered 45.36 11.34 102 1029935 17745 78696606
Lymphadenopathy 45.31 11.34 952 1029085 52295 78662056
Alcohol interaction 45.29 11.34 5 1030032 4869 78709482
Cardiomegaly 45.08 11.34 181 1029856 26171 78688180
Blood glucose fluctuation 45.06 11.34 15 1030022 6667 78707684
Thyroid neoplasm 44.85 11.34 115 1029922 3049 78711302
Chronic graft versus host disease in liver 44.79 11.34 49 1029988 618 78713733
Immune-mediated enterocolitis 44.77 11.34 5 1030032 4825 78709526
Erythrodermic psoriasis 44.72 11.34 81 1029956 1677 78712674
Sleep disorder due to a general medical condition 44.70 11.34 72 1029965 14205 78700146
Dislocation of vertebra 44.61 11.34 211 1029826 7669 78706682
Iritis 44.55 11.34 130 1029907 3725 78710626
Knee deformity 44.50 11.34 68 1029969 1217 78713134
Exostosis 44.45 11.34 371 1029666 16487 78697864
Osteonecrosis of jaw 44.43 11.34 351 1029686 42875 78671476
Nail psoriasis 44.39 11.34 48 1029989 597 78713754
Refusal of treatment by patient 44.19 11.34 31 1030006 8960 78705391
Disturbance in social behaviour 43.98 11.34 6 1030031 4964 78709387
Ageusia 43.97 11.34 93 1029944 16539 78697812
Joint laxity 43.91 11.34 95 1029942 2249 78712102
Personality change 43.80 11.34 40 1029997 10130 78704221
Respiration abnormal 43.66 11.34 23 1030014 7765 78706586
Device breakage 43.63 11.34 44 1029993 10631 78703720
Influenza 43.58 11.34 2070 1027967 127536 78586815
Metastases to bone 43.56 11.34 165 1029872 24262 78690089
Granulomatosis with polyangiitis 43.49 11.34 107 1029930 2763 78711588
Left ventricular dysfunction 43.46 11.34 118 1029919 19243 78695108
Dizziness postural 43.44 11.34 51 1029986 11498 78702853
Chemotherapeutic drug level above therapeutic 43.40 11.34 22 1030015 70 78714281
Lung adenocarcinoma 43.38 11.34 209 1029828 7655 78706696
Psychomotor retardation 43.28 11.34 13 1030024 6171 78708180
Heart rate decreased 43.12 11.34 1202 1028835 69114 78645237
Metabolic encephalopathy 43.06 11.34 33 1030004 9114 78705237
Palmoplantar pustulosis 42.98 11.34 45 1029992 538 78713813
Cardiomyopathy 42.94 11.34 208 1029829 28566 78685785
Hyperprolactinaemia 42.94 11.34 5 1030032 4671 78709680
Bone disorder 42.86 11.34 406 1029631 18707 78695644
Ear pain 42.83 11.34 629 1029408 32240 78682111
Arteriosclerosis coronary artery 42.74 11.34 105 1029932 17711 78696640
Myelodysplastic syndrome 42.74 11.34 588 1029449 29713 78684638
Ventricular hypertrophy 42.73 11.34 18 1030019 6920 78707431
Throat tightness 42.66 11.34 200 1029837 27707 78686644
Infusion site swelling 42.58 11.34 24 1030013 7802 78706549
Performance status decreased 42.51 11.34 13 1030024 6100 78708251
Hyperlactacidaemia 42.49 11.34 10 1030027 5585 78708766
Gastric haemorrhage 42.49 11.34 81 1029956 14969 78699382
Tonsillar ulcer 42.49 11.34 39 1029998 392 78713959
Therapeutic product effect delayed 42.44 11.34 110 1029927 2936 78711415
Neutropenia 42.42 11.34 3170 1026867 284540 78429811
Post procedural haemorrhage 42.39 11.34 70 1029967 13674 78700677
Hallucinations, mixed 42.32 11.34 18 1030019 6881 78707470
Vein rupture 42.20 11.34 86 1029951 1950 78712401
Rheumatic disorder 41.92 11.34 112 1029925 3046 78711305
Peritoneal tuberculosis 41.91 11.34 42 1029995 475 78713876
Rhinorrhoea 41.88 11.34 1283 1028754 74791 78639560
Oxygen consumption increased 41.79 11.34 7 1030030 4972 78709379
Clonus 41.72 11.34 18 1030019 6822 78707529
Cyst 41.66 11.34 314 1029723 13526 78700825
X-ray abnormal 41.58 11.34 167 1029870 5646 78708705
Joint ankylosis 41.58 11.34 89 1029948 2091 78712260
Gastrointestinal toxicity 41.52 11.34 211 1029826 7898 78706453
Amnesia 41.43 11.34 569 1029468 62488 78651863
Azotaemia 41.39 11.34 28 1030009 8248 78706103
Small intestinal obstruction 41.37 11.34 196 1029841 27076 78687275
Lipodystrophy acquired 41.32 11.34 4 1030033 4321 78710030
Granuloma 41.17 11.34 214 1029823 8083 78706268
Encephalitis 41.17 11.34 329 1029708 14431 78699920
Clear cell renal cell carcinoma 41.14 11.34 98 1029939 2478 78711873
C-reactive protein decreased 41.00 11.34 100 1029937 2568 78711783
Normal newborn 40.97 11.34 20 1030017 7052 78707299
Tuberculous pleurisy 40.81 11.34 46 1029991 601 78713750
Product prescribing error 40.64 11.34 376 1029661 44437 78669914
Abscess bacterial 40.63 11.34 52 1029985 782 78713569
Transaminases increased 40.48 11.34 914 1029123 50829 78663522
Diastolic dysfunction 40.39 11.34 48 1029989 10763 78703588
Breast cancer stage I 40.28 11.34 18 1030019 6682 78707669
Blood prolactin increased 40.26 11.34 3 1030034 4008 78710343
Product complaint 40.24 11.34 69 1029968 13280 78701071
Humoral immune defect 40.18 11.34 38 1029999 398 78713953
Joint space narrowing 40.17 11.34 47 1029990 641 78713710
Incorrect product administration duration 40.17 11.34 58 1029979 11964 78702387
Lung cancer metastatic 40.15 11.34 122 1029915 3577 78710774
Atrial tachycardia 40.08 11.34 21 1030016 7112 78707239
Myelitis transverse 40.07 11.34 82 1029955 1865 78712486
Musculoskeletal discomfort 39.94 11.34 412 1029625 19423 78694928
Wrist surgery 39.90 11.34 51 1029986 766 78713585
Acute myeloid leukaemia 39.84 11.34 590 1029447 30295 78684056
Bacterial infection 39.74 11.34 596 1029441 30684 78683667
Behaviour disorder 39.49 11.34 16 1030021 6297 78708054
Hepatitis B virus test positive 39.47 11.34 40 1029997 459 78713892
Hypophysitis 39.42 11.34 4 1030033 4162 78710189
Rheumatoid vasculitis 39.40 11.34 40 1029997 460 78713891
Neoplasm recurrence 39.37 11.34 132 1029905 4082 78710269
Hyperuricaemia 39.35 11.34 57 1029980 11742 78702609
Hypotonia 39.28 11.34 66 1029971 12804 78701547
Axial spondyloarthritis 39.27 11.34 43 1029994 543 78713808
Organising pneumonia 39.25 11.34 259 1029778 10680 78703671
Coordination abnormal 39.25 11.34 105 1029932 17207 78697144
Ear infection 39.17 11.34 644 1029393 33788 78680563
Jaundice cholestatic 39.14 11.34 53 1029984 11231 78703120
Toxic skin eruption 38.85 11.34 152 1029885 22141 78692210
Obsessive-compulsive disorder 38.77 11.34 14 1030023 5913 78708438
Priapism 38.56 11.34 6 1030031 4499 78709852
Retinal toxicity 38.45 11.34 67 1029970 1344 78713007
Mucosal toxicity 38.43 11.34 43 1029994 557 78713794
Ureaplasma infection 38.40 11.34 57 1029980 993 78713358
Osteomyelitis 38.25 11.34 617 1029420 32248 78682103
Therapy partial responder 38.24 11.34 368 1029669 17029 78697322
Cerebral haematoma 38.23 11.34 28 1030009 7914 78706437
Alveolitis 38.23 11.34 130 1029907 4050 78710301
Infective tenosynovitis 38.22 11.34 36 1030001 375 78713976
Bicytopenia 38.20 11.34 140 1029897 4530 78709821
Blood bicarbonate decreased 38.02 11.34 10 1030027 5181 78709170
Viral haemorrhagic cystitis 38.00 11.34 83 1029954 1978 78712373
Inhibitory drug interaction 37.96 11.34 6 1030031 4447 78709904
Eye disorder 37.92 11.34 466 1029571 22946 78691405
Foetal death 37.90 11.34 29 1030008 8015 78706336
Bone tuberculosis 37.90 11.34 42 1029995 538 78713813
Diffuse large B-cell lymphoma stage III 37.89 11.34 21 1030016 84 78714267
Blood chloride decreased 37.86 11.34 30 1030007 8147 78706204
Thrombotic microangiopathy 37.83 11.34 413 1029624 19756 78694595
Joint warmth 37.77 11.34 72 1029965 1552 78712799
Lip ulceration 37.72 11.34 89 1029948 2236 78712115
Aspiration bone marrow abnormal 37.61 11.34 25 1030012 148 78714203
Cerebral venous sinus thrombosis 37.50 11.34 88 1029949 2203 78712148
Adverse drug reaction 37.43 11.34 1123 1028914 65269 78649082
Human herpesvirus 6 infection 37.40 11.34 153 1029884 5217 78709134
Bursitis 37.36 11.34 661 1029376 35183 78679168
Pericardial effusion 37.32 11.34 399 1029638 45838 78668513
Ovarian neoplasm 37.22 11.34 43 1029994 578 78713773
Viral vasculitis 37.19 11.34 24 1030013 134 78714217
Rheumatoid arthritis-associated interstitial lung disease 37.17 11.34 15 1030022 22 78714329
Psoriasis area severity index increased 37.08 11.34 22 1030015 103 78714248
Aplasia pure red cell 36.99 11.34 28 1030009 7782 78706569
International normalised ratio decreased 36.88 11.34 30 1030007 8040 78706311
Alanine aminotransferase abnormal 36.85 11.34 218 1029819 8649 78705702
Lyme disease 36.84 11.34 111 1029926 3239 78711112
Obliterative bronchiolitis 36.82 11.34 104 1029933 2924 78711427
Synovial disorder 36.73 11.34 80 1029957 1903 78712448
Secretion discharge 36.67 11.34 325 1029712 14697 78699654
Cardioactive drug level increased 36.60 11.34 3 1030034 3706 78710645
Keratitis 36.57 11.34 131 1029906 4191 78710160
Sciatica 36.55 11.34 618 1029419 32604 78681747
Ovarian cancer 36.55 11.34 123 1029914 3811 78710540
Hidradenitis 36.48 11.34 104 1029933 2940 78711411
Palindromic rheumatism 36.42 11.34 36 1030001 400 78713951
Blister 36.39 11.34 1890 1028147 117586 78596765
Eye swelling 36.29 11.34 197 1029840 26271 78688080
Dyspnoea at rest 36.13 11.34 25 1030012 7277 78707074
Mixed liver injury 36.11 11.34 27 1030010 7551 78706800
Urine leukocyte esterase positive 36.05 11.34 5 1030032 4086 78710265
Abortion spontaneous 36.00 11.34 228 1029809 29279 78685072
Dermatitis psoriasiform 35.99 11.34 98 1029939 2696 78711655
Alcohol use 35.98 11.34 9 1030028 4822 78709529
Carcinoma in situ of skin 35.96 11.34 25 1030012 161 78714190
Incoherent 35.90 11.34 28 1030009 7664 78706687
Osteosclerosis 35.88 11.34 123 1029914 3848 78710503
Hepatitis 35.69 11.34 958 1029079 54769 78659582
T-cell lymphoma 35.68 11.34 62 1029975 1241 78713110
Leukopenia 35.66 11.34 1844 1028193 114669 78599682
Systemic lupus erythematosus rash 35.55 11.34 76 1029961 1784 78712567
Septic arthritis staphylococcal 35.54 11.34 48 1029989 763 78713588
Sputum increased 35.52 11.34 8 1030029 4605 78709746
Pseudomonal sepsis 35.45 11.34 166 1029871 6008 78708343
Thrombosis in device 35.35 11.34 13 1030024 5429 78708922
Non-Hodgkin's lymphoma 35.28 11.34 67 1029970 1440 78712911
Bunion operation 35.28 11.34 52 1029985 900 78713451
Hypoglycaemic coma 35.19 11.34 9 1030028 4751 78709600
N-terminal prohormone brain natriuretic peptide increased 35.14 11.34 9 1030028 4746 78709605
Anal abscess 35.10 11.34 224 1029813 9131 78705220
Compartment syndrome 35.00 11.34 11 1030026 5071 78709280
Gastrointestinal inflammation 34.99 11.34 191 1029846 7353 78706998
Blood pressure inadequately controlled 34.99 11.34 18 1030019 6159 78708192
Ovarian hyperstimulation syndrome 34.93 11.34 3 1030034 3568 78710783
Adverse event 34.89 11.34 1022 1029015 59192 78655159
Ileal stenosis 34.86 11.34 88 1029949 2310 78712041
Cold sweat 34.86 11.34 124 1029913 18575 78695776
Swollen joint count increased 34.86 11.34 451 1029586 22476 78691875
Urine ketone body present 34.86 11.34 3 1030034 3562 78710789
Iris adhesions 34.75 11.34 39 1029998 507 78713844
Human rhinovirus test positive 34.73 11.34 37 1030000 452 78713899
Nail disorder 34.61 11.34 267 1029770 11585 78702766
Arteriospasm coronary 34.57 11.34 22 1030015 6694 78707657
Abdominal wall haematoma 34.55 11.34 10 1030027 4863 78709488
Rheumatic fever 34.51 11.34 539 1029498 27986 78686365
Spinal column injury 34.43 11.34 83 1029954 2115 78712236
Tongue oedema 34.38 11.34 25 1030012 7092 78707259
Genital haemorrhage 34.29 11.34 19 1030018 6236 78708115
Bronchial carcinoma 34.23 11.34 59 1029978 1173 78713178
Dysstasia 34.22 11.34 526 1029511 27220 78687131
Immune system disorder 34.20 11.34 252 1029785 10777 78703574
Ammonia increased 34.13 11.34 29 1030008 7606 78706745
Antinuclear antibody positive 34.10 11.34 196 1029841 7694 78706657
Toe operation 34.05 11.34 40 1029997 548 78713803
Cross sensitivity reaction 34.01 11.34 4 1030033 3708 78710643
Skin mass 34.00 11.34 199 1029838 7864 78706487
Cutaneous lymphoma 34.00 11.34 28 1030009 240 78714111
Bone marrow oedema 33.96 11.34 71 1029966 1640 78712711
Tendonitis 33.84 11.34 463 1029574 23367 78690984
Nasal polyps 33.78 11.34 27 1030010 7300 78707051
Blood stem cell transplant failure 33.68 11.34 38 1029999 497 78713854
Coronary arterial stent insertion 33.66 11.34 18 1030019 6026 78708325
Granulocytopenia 33.62 11.34 60 1029977 11371 78702980
Angioimmunoblastic T-cell lymphoma stage III 33.62 11.34 10 1030027 0 78714351
Skin papilloma 33.61 11.34 158 1029879 5728 78708623
Eosinophil count increased 33.54 11.34 111 1029926 16994 78697357
Pulse absent 33.50 11.34 49 1029988 10054 78704297
Tender joint count 33.34 11.34 25 1030012 184 78714167
Viral mutation identified 33.34 11.34 5 1030032 3853 78710498
Muscle haemorrhage 33.31 11.34 20 1030017 6280 78708071
Inflammatory bowel disease 33.23 11.34 153 1029884 5498 78708853
Coronary artery occlusion 33.14 11.34 95 1029942 15220 78699131
Iron deficiency anaemia 33.08 11.34 195 1029842 25477 78688874
Anal fissure 33.06 11.34 191 1029846 7512 78706839
Hypergammaglobulinaemia benign monoclonal 33.06 11.34 48 1029989 819 78713532
Bloody discharge 33.04 11.34 76 1029961 1877 78712474
Toxic leukoencephalopathy 33.03 11.34 56 1029981 1098 78713253
Lung transplant 33.01 11.34 9 1030028 4552 78709799
Dissociation 32.99 11.34 6 1030031 4015 78710336
Pharyngeal ulceration 32.96 11.34 55 1029982 1064 78713287
Therapy interrupted 32.91 11.34 253 1029784 31088 78683263
Alcohol abuse 32.89 11.34 14 1030023 5349 78709002
Acute pulmonary histoplasmosis 32.82 11.34 27 1030010 231 78714120
Visual acuity reduced 32.80 11.34 234 1029803 29235 78685116
Subdural haemorrhage 32.71 11.34 18 1030019 5930 78708421
Muscle tightness 32.67 11.34 74 1029963 12840 78701511
Drooling 32.57 11.34 18 1030019 5916 78708435
Viral upper respiratory tract infection 32.56 11.34 214 1029823 8812 78705539
Herpes simplex 32.56 11.34 269 1029768 11918 78702433
Hepatitis acute 32.48 11.34 98 1029939 15444 78698907
Mental impairment 32.40 11.34 131 1029906 18905 78695446
Pruritus 32.29 11.34 4536 1025501 390112 78324239
Duodenal ulcer haemorrhage 32.27 11.34 27 1030010 7136 78707215
Leukoerythroblastosis 32.26 11.34 29 1030008 283 78714068
Epstein-Barr virus test positive 32.24 11.34 55 1029982 1084 78713267
Pruritus genital 32.19 11.34 9 1030028 4477 78709874
Blood triglycerides increased 32.04 11.34 151 1029886 20889 78693462
Infusion site pruritus 32.00 11.34 7 1030030 4111 78710240
Morphoea 31.93 11.34 34 1030003 415 78713936
Immune thrombocytopenia 31.93 11.34 120 1029917 17685 78696666
Inadequate analgesia 31.91 11.34 10 1030027 4619 78709732
Gout 31.88 11.34 188 1029849 24561 78689790
Bursitis infective 31.81 11.34 59 1029978 1245 78713106
Hyperventilation 31.78 11.34 33 1030004 7866 78706485
Mucocutaneous leishmaniasis 31.78 11.34 35 1030002 445 78713906
Nocturia 31.76 11.34 82 1029955 13599 78700752
Limb operation 31.73 11.34 107 1029930 3319 78711032
Cardiospasm 31.68 11.34 3 1030034 3298 78711053
Multiple drug therapy 31.55 11.34 7 1030030 4071 78710280
Tension headache 31.49 11.34 28 1030009 7183 78707168
Sudden cardiac death 31.47 11.34 14 1030023 5211 78709140
Multiple injuries 31.45 11.34 4 1030033 3491 78710860
Application site pain 31.42 11.34 11 1030026 4736 78709615
Blood thyroid stimulating hormone increased 31.31 11.34 48 1029989 9660 78704691
Weight increased 31.05 11.34 4064 1025973 273322 78441029
Blood pH decreased 31.04 11.34 11 1030026 4700 78709651
Congestive hepatopathy 31.03 11.34 10 1030027 4537 78709814
Pregnancy with contraceptive device 30.97 11.34 5 1030032 3649 78710702
Carpal tunnel syndrome 30.90 11.34 387 1029650 19141 78695210
Increased appetite 30.82 11.34 68 1029969 11910 78702441
Rales 30.78 11.34 143 1029894 19858 78694493
Therapy cessation 30.77 11.34 323 1029714 37239 78677112
Liver function test abnormal 30.74 11.34 1069 1028968 63406 78650945
Tendon disorder 30.72 11.34 178 1029859 7008 78707343
Anaplastic large-cell lymphoma 30.66 11.34 25 1030012 211 78714140
Panic attack 30.64 11.34 185 1029852 24031 78690320
Decubitus ulcer 30.62 11.34 102 1029935 15585 78698766
Syringe issue 30.58 11.34 22 1030015 6276 78708075
Decreased immune responsiveness 30.56 11.34 146 1029891 5329 78709022
Myelodysplastic syndrome transformation 30.53 11.34 41 1029996 648 78713703
Graft versus host disease in liver 30.50 11.34 69 1029968 1685 78712666
Rash macular 30.48 11.34 233 1029804 28666 78685685
Oligohydramnios 30.48 11.34 4 1030033 3408 78710943
High density lipoprotein decreased 30.44 11.34 11 1030026 4644 78709707
Tongue ulceration 30.43 11.34 121 1029916 4072 78710279
Retinal pigment epitheliopathy 30.41 11.34 34 1030003 440 78713911
Coronary artery stenosis 30.40 11.34 73 1029964 12411 78701940
Intervertebral disc protrusion 30.37 11.34 451 1029586 23170 78691181
Catheter site haemorrhage 30.37 11.34 14 1030023 5103 78709248
Blood uric acid increased 30.31 11.34 81 1029956 13279 78701072
Duodenal ulcer 30.22 11.34 109 1029928 16260 78698091
Blood phosphorus decreased 30.21 11.34 25 1030012 6643 78707708
Stillbirth 30.17 11.34 7 1030030 3948 78710403
Restless legs syndrome 30.12 11.34 145 1029892 19947 78694404
Subdural hygroma 30.10 11.34 35 1030002 474 78713877
Conduction disorder 30.09 11.34 4 1030033 3375 78710976
Nodular regenerative hyperplasia 30.02 11.34 59 1029978 1302 78713049
Anaemia megaloblastic 30.01 11.34 39 1029998 596 78713755
Electrocardiogram T wave inversion 29.92 11.34 16 1030021 5356 78708995
Cytotoxic oedema 29.91 11.34 31 1030006 366 78713985
Stress cardiomyopathy 29.89 11.34 62 1029975 11104 78703247
Spinal disorder 29.88 11.34 231 1029806 10029 78704322
Injection site inflammation 29.88 11.34 116 1029921 3860 78710491
Blood iron abnormal 29.84 11.34 59 1029978 1308 78713043
Second primary malignancy 29.81 11.34 300 1029737 14050 78700301
Pneumonia 29.81 11.34 7828 1022209 652418 78061933
Incorrect disposal of product 29.80 11.34 49 1029988 936 78713415
JC virus infection 29.79 11.34 114 1029923 3767 78710584
Hepatosplenomegaly 29.74 11.34 156 1029881 5913 78708438
Communication disorder 29.73 11.34 8 1030029 4082 78710269
Hypovolaemic shock 29.73 11.34 72 1029965 12204 78702147
Immunosuppressant drug level increased 29.72 11.34 44 1029993 8983 78705368
Vascular access complication 29.59 11.34 78 1029959 2104 78712247
Infusion site haemorrhage 29.57 11.34 6 1030031 3714 78710637
Mitochondrial toxicity 29.44 11.34 3 1030034 3111 78711240
Engraft failure 29.44 11.34 41 1029996 672 78713679
Pulmonary arterial pressure increased 29.39 11.34 11 1030026 4544 78709807
Underdose 29.27 11.34 280 1029757 32871 78681480
Left ventricular hypertrophy 29.23 11.34 63 1029974 11128 78703223
Prostatic specific antigen increased 29.23 11.34 56 1029981 10330 78704021
West Nile viral infection 29.18 11.34 49 1029988 953 78713398
Thyroid cancer 29.03 11.34 146 1029891 5442 78708909
Injection site discolouration 28.99 11.34 183 1029854 7431 78706920
Transaminases abnormal 28.98 11.34 45 1029992 817 78713534
Diffuse alopecia 28.89 11.34 48 1029989 925 78713426
Mycobacterium avium complex infection 28.89 11.34 127 1029910 4473 78709878
Gastrointestinal pain 28.77 11.34 222 1029815 9633 78704718
Intertrigo 28.77 11.34 44 1029993 788 78713563
Ataxia 28.77 11.34 197 1029840 24842 78689509
Nervousness 28.75 11.34 284 1029753 33131 78681220
Tender joint count increased 28.74 11.34 26 1030011 256 78714095
Neck mass 28.74 11.34 123 1029914 4281 78710070
Ankle operation 28.69 11.34 51 1029986 1040 78713311
Muscular weakness 28.68 11.34 1741 1028296 158988 78555363
Self-injurious ideation 28.64 11.34 6 1030031 3632 78710719
Psychomotor skills impaired 28.58 11.34 16 1030021 5221 78709130
Ganglioneuroma 28.50 11.34 20 1030017 131 78714220
Choking 28.50 11.34 72 1029965 12029 78702322
Sinus arrest 28.46 11.34 6 1030031 3616 78710735
Disseminated sporotrichosis 28.44 11.34 14 1030023 41 78714310
Apoptotic colonopathy 28.38 11.34 19 1030018 114 78714237
Coronary artery bypass 28.37 11.34 22 1030015 6040 78708311
Haemolytic anaemia 28.26 11.34 126 1029911 17694 78696657
Colitis ulcerative 28.22 11.34 617 1029420 34125 78680226
Tearfulness 28.22 11.34 22 1030015 6023 78708328
Cytomegalovirus viraemia 28.08 11.34 271 1029766 12550 78701801
Medical device site joint infection 27.94 11.34 29 1030008 343 78714008
Rash morbilliform 27.93 11.34 23 1030014 6127 78708224
Meningoencephalitis herpetic 27.89 11.34 72 1029965 1917 78712434
Accidental exposure to product 27.89 11.34 264 1029773 31058 78683293
Colitis ischaemic 27.88 11.34 103 1029934 15256 78699095
Catheterisation cardiac 27.83 11.34 20 1030017 5708 78708643
Eye infection toxoplasmal 27.82 11.34 35 1030002 517 78713834
Pseudostroke 27.79 11.34 16 1030021 70 78714281
Gastritis 27.74 11.34 444 1029593 47549 78666802
Interferon gamma release assay positive 27.74 11.34 14 1030023 44 78714307
Hypertensive crisis 27.71 11.34 156 1029881 20614 78693737
Extrasystoles 27.65 11.34 33 1030004 7386 78706965
Post procedural infection 27.64 11.34 246 1029791 11138 78703213
Blood calcium increased 27.62 11.34 58 1029979 10342 78704009
Intestinal sepsis 27.57 11.34 45 1029992 854 78713497
Anion gap increased 27.57 11.34 7 1030030 3713 78710638
Anticipatory anxiety 27.54 11.34 53 1029984 1151 78713200
Meningitis tuberculous 27.51 11.34 53 1029984 1152 78713199
Peripheral T-cell lymphoma unspecified 27.48 11.34 39 1029998 651 78713700
Alcohol poisoning 27.38 11.34 14 1030023 4807 78709544
Social avoidant behaviour 27.31 11.34 14 1030023 4800 78709551
Crystal nephropathy 27.29 11.34 59 1029978 1396 78712955
Oliguria 27.28 11.34 113 1029924 16196 78698155
Blood cholesterol increased 27.26 11.34 1333 1028704 82387 78631964
Cushingoid 27.24 11.34 214 1029823 9338 78705013
Central nervous system lymphoma 27.23 11.34 78 1029959 2211 78712140
Feeling hot 27.21 11.34 576 1029461 59158 78655193
Soft tissue swelling 27.17 11.34 60 1029977 1441 78712910
Blood sodium increased 27.15 11.34 14 1030023 4784 78709567
Hypertonia 27.13 11.34 32 1030005 7200 78707151
Gait inability 27.13 11.34 973 1029064 57944 78656407
Foetal exposure during pregnancy 27.12 11.34 21 1030016 5769 78708582
Hip fracture 27.08 11.34 260 1029777 30501 78683850
Epstein-Barr viraemia 27.08 11.34 76 1029961 2129 78712222
Tooth disorder 27.07 11.34 483 1029554 25750 78688601
Akinesia 27.05 11.34 5 1030032 3307 78711044
Lip oedema 27.02 11.34 25 1030012 6291 78708060
Enterovirus test positive 27.00 11.34 26 1030011 279 78714072
Cytopenia 26.92 11.34 391 1029646 19992 78694359
Malnutrition 26.87 11.34 175 1029862 22327 78692024
Folate deficiency 26.87 11.34 100 1029937 3260 78711091
Plantar fasciitis 26.86 11.34 102 1029935 3358 78710993
Lung squamous cell carcinoma recurrent 26.82 11.34 10 1030027 10 78714341
Enterovirus infection 26.81 11.34 70 1029967 1877 78712474
Cutaneous tuberculosis 26.79 11.34 23 1030014 210 78714141
Herpes simplex reactivation 26.77 11.34 32 1030005 447 78713904
Coccidioidomycosis 26.70 11.34 55 1029982 1257 78713094
Homicidal ideation 26.61 11.34 6 1030031 3451 78710900
Discouragement 26.60 11.34 63 1029974 1587 78712764
Vasoplegia syndrome 26.58 11.34 7 1030030 3623 78710728
Invasive ductal breast carcinoma 26.54 11.34 148 1029889 5744 78708607
Mucormycosis 26.54 11.34 194 1029843 8275 78706076
Anticoagulation drug level above therapeutic 26.47 11.34 7 1030030 3613 78710738
Rheumatoid factor 26.43 11.34 29 1030008 367 78713984
Anaesthetic complication 26.40 11.34 3 1030034 2856 78711495
Multiple fractures 26.40 11.34 186 1029851 7840 78706511
Central nervous system leukaemia 26.38 11.34 30 1030007 396 78713955
Lipase increased 26.37 11.34 116 1029921 16350 78698001
Drug eruption 26.36 11.34 749 1029288 43186 78671165
Acute promyelocytic leukaemia 26.31 11.34 59 1029978 1432 78712919
Photosensitivity reaction 26.24 11.34 401 1029636 20726 78693625
Screaming 26.23 11.34 9 1030028 3924 78710427
Tonsil cancer 26.21 11.34 51 1029986 1117 78713234
Atelectasis 26.18 11.34 278 1029759 31979 78682372
Iridocyclitis 26.17 11.34 106 1029931 3598 78710753
Pleural fibrosis 26.14 11.34 115 1029922 4052 78710299
Listeriosis 26.12 11.34 76 1029961 2174 78712177
Eye pruritus 26.10 11.34 157 1029880 20413 78693938
Metastatic bronchial carcinoma 26.09 11.34 24 1030013 242 78714109
Dry eye 26.02 11.34 643 1029394 36288 78678063
Herpes virus infection 25.96 11.34 168 1029869 6881 78707470
Acute lymphocytic leukaemia 25.94 11.34 130 1029907 4839 78709512
Nephrogenic anaemia 25.90 11.34 9 1030028 3893 78710458
Benign prostatic hyperplasia 25.89 11.34 71 1029966 11541 78702810
Eczema 25.86 11.34 371 1029666 40447 78673904
Extra dose administered 25.82 11.34 43 1029994 8372 78705979
Logorrhoea 25.82 11.34 12 1030025 4353 78709998
Nystagmus 25.67 11.34 56 1029981 9848 78704503
Acute myeloid leukaemia recurrent 25.66 11.34 99 1029938 3284 78711067
Polyomavirus-associated nephropathy 25.61 11.34 21 1030016 5606 78708745
Pericardial haemorrhage 25.61 11.34 13 1030024 4482 78709869
Spondylitis 25.57 11.34 125 1029912 4606 78709745
Q fever 25.55 11.34 24 1030013 249 78714102
Generalised oedema 25.55 11.34 190 1029847 23519 78690832
Product residue present 25.55 11.34 7 1030030 3529 78710822
Cerebral venous thrombosis 25.51 11.34 86 1029951 2667 78711684
Anaemia macrocytic 25.49 11.34 141 1029896 5456 78708895
Hereditary angioedema 25.43 11.34 19 1030018 5316 78709035
Sexual dysfunction 25.40 11.34 38 1029999 7725 78706626
Kidney infection 25.34 11.34 410 1029627 21441 78692910
Purpura 25.33 11.34 148 1029889 19379 78694972
Cutaneous vasculitis 25.28 11.34 188 1029849 8064 78706287
Bone density abnormal 25.25 11.34 92 1029945 2968 78711383
PCO2 decreased 25.25 11.34 5 1030032 3149 78711202
Hyperphosphataemia 25.25 11.34 27 1030010 6349 78708002
Dermatitis allergic 25.24 11.34 351 1029686 17779 78696572
Urine abnormality 25.22 11.34 42 1029995 8177 78706174
Myoglobin blood increased 25.22 11.34 5 1030032 3146 78711205
Diabetic metabolic decompensation 25.22 11.34 6 1030031 3326 78711025
Human bocavirus infection 25.20 11.34 39 1029998 706 78713645
Traumatic lung injury 25.15 11.34 78 1029959 2313 78712038
Post-traumatic stress disorder 25.11 11.34 16 1030021 4865 78709486
Meningitis haemophilus 25.05 11.34 10 1030027 14 78714337
Nodal rhythm 25.04 11.34 5 1030032 3130 78711221
Linear IgA disease 25.00 11.34 5 1030032 3127 78711224
Craniosynostosis 24.99 11.34 15 1030022 72 78714279
Hypoventilation 24.99 11.34 34 1030003 7190 78707161
Diplopia 24.95 11.34 294 1029743 33172 78681179
Application site pruritus 24.92 11.34 9 1030028 3801 78710550
Hyperkinesia 24.86 11.34 3 1030034 2726 78711625
Eructation 24.85 11.34 66 1029971 10843 78703508
Mass excision 24.83 11.34 27 1030010 338 78714013
Pyrexia 24.82 11.34 8118 1021919 670591 78043760
Antibody test positive 24.80 11.34 86 1029951 2706 78711645
Intestinal ischaemia 24.74 11.34 88 1029949 13182 78701169
Infected dermal cyst 24.74 11.34 52 1029985 1206 78713145
Joint tuberculosis 24.70 11.34 19 1030018 146 78714205
Medication error 24.66 11.34 686 1029351 67956 78646395
Overlap syndrome 24.56 11.34 46 1029991 978 78713373
Radiation pneumonitis 24.55 11.34 10 1030027 3923 78710428
Onychomadesis 24.50 11.34 133 1029904 5109 78709242
Distributive shock 24.36 11.34 3 1030034 2684 78711667
Dermatitis atopic 24.33 11.34 59 1029978 9997 78704354
Blood urine present 24.25 11.34 168 1029869 21129 78693222
Aortic stenosis 24.23 11.34 37 1030000 7458 78706893
Herpes zoster oticus 24.21 11.34 30 1030007 436 78713915
Tropical infectious disease 24.18 11.34 12 1030025 36 78714315
Mucosal disorder 24.16 11.34 100 1029937 3428 78710923
Stupor 24.12 11.34 32 1030005 6840 78707511
Legionella infection 24.11 11.34 40 1029997 770 78713581
Cystitis 24.07 11.34 870 1029167 51862 78662489
Diffuse large B-cell lymphoma recurrent 24.07 11.34 113 1029924 4094 78710257
Pulmonary arteriopathy 24.03 11.34 16 1030021 95 78714256
Hyperparathyroidism 24.02 11.34 6 1030031 3218 78711133
Blood glucose abnormal 24.02 11.34 64 1029973 10502 78703849
Bone density decreased 23.98 11.34 271 1029766 13076 78701275
Anticonvulsant drug level increased 23.96 11.34 3 1030034 2650 78711701
Protein total decreased 23.90 11.34 51 1029986 9041 78705310
Multiple sclerosis 23.81 11.34 179 1029858 22103 78692248
Cartilage atrophy 23.81 11.34 19 1030018 155 78714196
Varicella zoster pneumonia 23.74 11.34 18 1030019 135 78714216
Troponin I increased 23.74 11.34 16 1030021 4722 78709629
Tibia fracture 23.71 11.34 134 1029903 5227 78709124
Chronic recurrent multifocal osteomyelitis 23.68 11.34 14 1030023 65 78714286
Corneal toxicity 23.66 11.34 9 1030028 10 78714341
Metabolic disorder 23.64 11.34 52 1029985 9118 78705233
Stress fracture 23.60 11.34 154 1029883 6326 78708025
Plasma cell myeloma recurrent 23.60 11.34 18 1030019 4983 78709368
Skin bacterial infection 23.59 11.34 32 1030005 511 78713840
Heavy chain disease 23.54 11.34 7 1030030 0 78714351
Foetal methotrexate syndrome 23.54 11.34 7 1030030 0 78714351
Osteophyte fracture 23.54 11.34 7 1030030 0 78714351
Hypersomnia 23.48 11.34 188 1029849 22898 78691453
Ocular hypertension 23.39 11.34 57 1029980 1463 78712888
Cerebral salt-wasting syndrome 23.34 11.34 17 1030020 119 78714232
Catheter site erythema 23.30 11.34 20 1030017 5220 78709131
Serum procollagen type III N-terminal propeptide increased 23.27 11.34 12 1030025 40 78714311
Cardiac murmur 23.26 11.34 115 1029922 15709 78698642
Red blood cells urine positive 23.24 11.34 18 1030019 4945 78709406
Red blood cell sedimentation rate 23.24 11.34 137 1029900 5428 78708923
Atrial septal defect acquired 23.22 11.34 10 1030027 19 78714332
Focal segmental glomerulosclerosis 23.21 11.34 7 1030030 3314 78711037
Incontinence 23.16 11.34 99 1029938 14065 78700286
Paradoxical psoriasis 23.15 11.34 22 1030015 232 78714119
Tendon rupture 23.06 11.34 249 1029788 11877 78702474
Supraventricular extrasystoles 23.06 11.34 34 1030003 6953 78707398
Meningitis aseptic 23.05 11.34 161 1029876 6767 78707584
Vaginal flatulence 23.04 11.34 3 1030034 2572 78711779
Vaginal discharge 23.03 11.34 38 1029999 7425 78706926
Mass 23.01 11.34 335 1029702 17137 78697214
Terminal ileitis 23.01 11.34 42 1029995 875 78713476
Laryngitis 22.93 11.34 312 1029725 15727 78698624
Apnoea 22.91 11.34 76 1029961 11628 78702723
Infection reactivation 22.88 11.34 81 1029956 2576 78711775
Micturition urgency 22.79 11.34 85 1029952 12556 78701795
Aspergillus infection 22.77 11.34 361 1029676 18800 78695551
Hot flush 22.76 11.34 537 1029500 54340 78660011
Self-consciousness 22.67 11.34 15 1030022 88 78714263
Middle lobe syndrome 22.65 11.34 11 1030026 31 78714320
Carotid artery occlusion 22.62 11.34 40 1029997 7607 78706744
Bursitis infective staphylococcal 22.59 11.34 14 1030023 72 78714279
Hyperthermia malignant 22.58 11.34 5 1030032 2912 78711439
Cytology abnormal 22.51 11.34 25 1030012 321 78714030
Hair follicle tumour benign 22.42 11.34 29 1030008 441 78713910
Product preparation error 22.42 11.34 25 1030012 5768 78708583
Protein urine present 22.42 11.34 62 1029975 10050 78704301
Rash erythematous 22.41 11.34 571 1029466 57198 78657153
Laryngeal disorder 22.37 11.34 46 1029991 1050 78713301
Fusarium infection 22.35 11.34 63 1029974 1769 78712582
Sinusitis bacterial 22.34 11.34 62 1029975 1725 78712626
Small intestinal haemorrhage 22.32 11.34 13 1030024 4150 78710201
Encephalitis fungal 22.25 11.34 19 1030018 172 78714179
Oesophageal squamous cell carcinoma 22.25 11.34 30 1030007 476 78713875
Visual impairment 22.16 11.34 968 1029069 91163 78623188
Bradyarrhythmia 22.15 11.34 13 1030024 4133 78710218
Sinus node dysfunction 22.14 11.34 41 1029996 7660 78706691
Tumour haemorrhage 22.13 11.34 13 1030024 4131 78710220
Procedural haemorrhage 22.13 11.34 17 1030020 4689 78709662
Haemorrhagic transformation stroke 22.12 11.34 4 1030033 2688 78711663
Laryngospasm 22.12 11.34 12 1030025 3985 78710366
Osteonecrosis 22.09 11.34 542 1029495 30553 78683798
Nasopharyngeal cancer 22.08 11.34 19 1030018 174 78714177
Haemorrhoids 22.06 11.34 255 1029782 28873 78685478
Exposure to communicable disease 22.04 11.34 31 1030006 513 78713838
Myelosuppression 22.01 11.34 679 1029358 39617 78674734
Ependymoma malignant 22.00 11.34 9 1030028 14 78714337
Haemolysis 21.91 11.34 88 1029949 12724 78701627
Troponin T increased 21.91 11.34 9 1030028 3513 78710838
Immune effector cell-associated neurotoxicity syndrome 21.81 11.34 26 1030011 5822 78708529
Meniscus injury 21.77 11.34 156 1029881 6612 78707739
Bronchial secretion retention 21.74 11.34 13 1030024 4091 78710260
Cholesteatoma 21.64 11.34 16 1030021 115 78714236
Mucosal necrosis 21.64 11.34 16 1030021 115 78714236
Cardiac pacemaker insertion 21.59 11.34 26 1030011 5796 78708555
Fistula 21.58 11.34 259 1029778 12681 78701670
Myeloid leukaemia 21.55 11.34 36 1030001 697 78713654
Unintended pregnancy 21.49 11.34 12 1030025 3921 78710430
Norovirus test positive 21.48 11.34 34 1030003 628 78713723
Ischaemia 21.48 11.34 45 1029992 8030 78706321
Red blood cell sedimentation rate decreased 21.47 11.34 22 1030015 256 78714095
Depressive symptom 21.45 11.34 31 1030006 6392 78707959
Haematopoietic neoplasm 21.44 11.34 14 1030023 80 78714271
Cervix carcinoma 21.43 11.34 71 1029966 2182 78712169
Orthopnoea 21.42 11.34 63 1029974 10010 78704341
Trigger finger 21.42 11.34 110 1029927 4135 78710216
Localised oedema 21.41 11.34 44 1029993 7908 78706443
Stress 21.40 11.34 1245 1028792 78367 78635984
Exercise tolerance decreased 21.34 11.34 54 1029983 9017 78705334
Embolic stroke 21.33 11.34 43 1029994 7783 78706568
Blood albumin decreased 21.30 11.34 205 1029832 24038 78690313
Neck deformity 21.28 11.34 62 1029975 1775 78712576
Cerebrosclerosis 21.27 11.34 9 1030028 16 78714335
Spinal fusion surgery 21.27 11.34 128 1029909 5110 78709241
Squamous cell carcinoma of the oral cavity 21.26 11.34 30 1030007 498 78713853
Sweat gland tumour 21.26 11.34 30 1030007 498 78713853
Device malfunction 21.20 11.34 176 1029861 21272 78693079
Intervertebral disc annular tear 21.15 11.34 10 1030027 26 78714325
Growth failure 21.13 11.34 21 1030016 235 78714116
Device use issue 21.10 11.34 5 1030032 2779 78711572
Scleroderma renal crisis 21.09 11.34 32 1030005 569 78713782
Endocarditis bacterial 21.08 11.34 55 1029982 1474 78712877
Thrombotic thrombocytopenic purpura 21.07 11.34 31 1030006 6345 78708006
Empyema 21.02 11.34 110 1029927 4166 78710185
Antithrombin III decreased 21.01 11.34 29 1030008 471 78713880
Pulmonary congestion 21.01 11.34 236 1029801 26864 78687487
Electrocardiogram T wave abnormal 21.01 11.34 11 1030026 3727 78710624
Glioblastoma multiforme 21.01 11.34 48 1029989 1180 78713171
Genital erosion 21.00 11.34 27 1030010 408 78713943
Feeling abnormal 20.97 11.34 1770 1028267 157429 78556922
Application site erythema 20.96 11.34 21 1030016 5089 78709262
Pachymeningitis 20.95 11.34 22 1030015 264 78714087
Liver injury 20.93 11.34 913 1029124 55701 78658650
Double stranded DNA antibody positive 20.83 11.34 28 1030009 443 78713908
Vascular purpura 20.81 11.34 7 1030030 3091 78711260
Accidental exposure to product by child 20.75 11.34 6 1030031 2920 78711431
Steatohepatitis 20.73 11.34 42 1029995 948 78713403
Viral infection 20.70 11.34 714 1029323 42302 78672049
Prosthesis user 20.66 11.34 13 1030024 69 78714282
Lacunar infarction 20.64 11.34 28 1030009 5929 78708422
Endometrial adenocarcinoma 20.63 11.34 44 1029993 1031 78713320
Arterial haemorrhage 20.63 11.34 4 1030033 2557 78711794
Fracture 20.61 11.34 396 1029641 21405 78692946
Papulopustular rosacea 20.60 11.34 9 1030028 18 78714333
Euphoric mood 20.59 11.34 43 1029994 7683 78706668
Extremity contracture 20.59 11.34 59 1029978 1673 78712678
Meningitis noninfective 20.59 11.34 12 1030025 54 78714297
CSF myelin basic protein increased 20.54 11.34 8 1030029 10 78714341
Low density lipoprotein increased 20.54 11.34 51 1029986 8571 78705780
Eye infection 20.51 11.34 240 1029797 11680 78702671
Dermatomyositis 20.50 11.34 97 1029940 3526 78710825
Progressive multifocal leukoencephalopathy 20.45 11.34 377 1029660 20223 78694128
Bronchopulmonary aspergillosis allergic 20.42 11.34 7 1030030 3054 78711297
Loose body in joint 20.39 11.34 49 1029988 1246 78713105
Oesophageal varices haemorrhage 20.31 11.34 15 1030022 4221 78710130
Hair colour changes 20.27 11.34 15 1030022 4217 78710134
Cytomegalovirus test positive 20.25 11.34 139 1029898 5808 78708543
T-cell type acute leukaemia 20.24 11.34 18 1030019 173 78714178
Paraplegia 20.21 11.34 123 1029914 4930 78709421
Hydronephrosis 20.21 11.34 137 1029900 17317 78697034
Atrial thrombosis 20.20 11.34 11 1030026 3645 78710706
Adactyly 20.17 11.34 6 1030031 0 78714351
Peripheral T-cell lymphoma unspecified stage II 20.17 11.34 6 1030031 0 78714351
Dysphotopsia 20.17 11.34 6 1030031 0 78714351
Arthritis viral 20.17 11.34 6 1030031 0 78714351
Oropharyngeal discolouration 20.17 11.34 6 1030031 0 78714351
Ankle arthroplasty 20.16 11.34 54 1029983 1471 78712880
Pyomyositis 20.14 11.34 32 1030005 593 78713758
Wheelchair user 20.10 11.34 142 1029895 5990 78708361
Laryngitis fungal 20.10 11.34 16 1030021 130 78714221
Skin haemorrhage 20.07 11.34 240 1029797 11741 78702610
Electrocardiogram ST segment depression 20.06 11.34 20 1030017 4858 78709493
Haemoperitoneum 20.03 11.34 16 1030021 4327 78710024
Pneumonitis 20.02 11.34 970 1029067 59890 78654461
Diarrhoea haemorrhagic 19.98 11.34 260 1029777 12974 78701377
Polycystic ovaries 19.98 11.34 12 1030025 3767 78710584
Renal artery stenosis 19.94 11.34 10 1030027 3472 78710879
Diffuse large B-cell lymphoma stage II 19.92 11.34 14 1030023 92 78714259
Actinomycotic pulmonary infection 19.91 11.34 10 1030027 31 78714320
Idiopathic pneumonia syndrome 19.88 11.34 31 1030006 565 78713786
Intervertebral disc compression 19.88 11.34 49 1029988 1267 78713084
Malignant neoplasm of conjunctiva 19.85 11.34 11 1030026 44 78714307
Tuberculosis of central nervous system 19.83 11.34 28 1030009 465 78713886
Peripheral T-cell lymphoma unspecified stage III 19.83 11.34 7 1030030 5 78714346
Antisynthetase syndrome 19.82 11.34 17 1030020 155 78714196
Salivary gland cancer 19.82 11.34 27 1030010 433 78713918
Eyelid oedema 19.81 11.34 100 1029937 13587 78700764
Breath sounds abnormal 19.76 11.34 123 1029914 15861 78698490
Ventricular hypokinesia 19.76 11.34 58 1029979 9221 78705130
Neutrophilia 19.76 11.34 46 1029991 7905 78706446
Psychiatric symptom 19.74 11.34 38 1029999 6997 78707354
Sensitisation 19.74 11.34 9 1030028 3302 78711049
Catheter site pruritus 19.73 11.34 3 1030034 2288 78712063
Refractoriness to platelet transfusion 19.72 11.34 16 1030021 134 78714217
Sinus congestion 19.71 11.34 364 1029673 19532 78694819
Incorrect dosage administered 19.69 11.34 80 1029957 2719 78711632
Stomatitis haemorrhagic 19.68 11.34 14 1030023 94 78714257
Osteosarcoma metastatic 19.66 11.34 11 1030026 45 78714306
Poor quality device used 19.66 11.34 3 1030034 2282 78712069
Infiltration anaesthesia 19.65 11.34 17 1030020 157 78714194
Pancreatitis 19.63 11.34 706 1029331 67869 78646482
Encephalitis brain stem 19.63 11.34 20 1030017 231 78714120
Burkitt's lymphoma 19.63 11.34 15 1030022 114 78714237
Nephrolithiasis 19.61 11.34 859 1029178 52432 78661919
Lip and/or oral cavity cancer 19.60 11.34 44 1029993 1069 78713282
Pregnancy 19.59 11.34 237 1029800 26614 78687737
Elbow operation 19.56 11.34 24 1030013 345 78714006
Pathogen resistance 19.52 11.34 107 1029930 14235 78700116
Angle closure glaucoma 19.52 11.34 7 1030030 2969 78711382
Hepatic cancer 19.51 11.34 70 1029967 10459 78703892
Ejection fraction 19.47 11.34 3 1030034 2266 78712085
Pulmonary sarcoidosis 19.47 11.34 50 1029987 1327 78713024
Symptom recurrence 19.46 11.34 70 1029967 2244 78712107
Gynaecomastia 19.44 11.34 44 1029993 7637 78706714
Alcoholism 19.43 11.34 12 1030025 3711 78710640
Pterygium 19.42 11.34 23 1030014 318 78714033
Device physical property issue 19.39 11.34 5 1030032 2625 78711726
Food allergy 19.38 11.34 73 1029964 10751 78703600
Breast cancer stage II 19.37 11.34 48 1029989 8072 78706279
Feeling cold 19.32 11.34 258 1029779 28471 78685880
Drug-device interaction 19.29 11.34 13 1030024 79 78714272
Tongue neoplasm malignant stage unspecified 19.25 11.34 43 1029994 1041 78713310
Gingivitis ulcerative 19.25 11.34 21 1030016 264 78714087
Thymus enlargement 19.22 11.34 15 1030022 118 78714233
Diabetic nephropathy 19.21 11.34 7 1030030 2940 78711411
Tachyarrhythmia 19.19 11.34 38 1029999 6924 78707427
Vaginal infection 19.18 11.34 136 1029901 5744 78708607
Cell marker increased 19.18 11.34 32 1030005 619 78713732
Erythema nodosum 19.14 11.34 126 1029911 5191 78709160
Wernicke's encephalopathy 19.14 11.34 9 1030028 23 78714328
Malignant respiratory tract neoplasm 19.14 11.34 9 1030028 23 78714328
Solar urticaria 19.11 11.34 14 1030023 99 78714252
Inability to afford medication 19.10 11.34 6 1030031 2767 78711584
Diverticular perforation 19.05 11.34 136 1029901 5757 78708594
Graft versus host disease in eye 18.97 11.34 22 1030015 297 78714054
Lymphoedema 18.95 11.34 89 1029948 12324 78702027
Colon cancer 18.95 11.34 278 1029759 14245 78700106
Catheter site discharge 18.95 11.34 4 1030033 2408 78711943
Cell-mediated immune deficiency 18.93 11.34 15 1030022 121 78714230
Subcutaneous abscess 18.90 11.34 171 1029866 7778 78706573
Postoperative wound infection 18.89 11.34 253 1029784 12708 78701643
Nipple swelling 18.86 11.34 22 1030015 299 78714052
Catheter site infection 18.81 11.34 37 1030000 6758 78707593
Matrix metalloproteinase-3 increased 18.77 11.34 7 1030030 7 78714344
BK virus infection 18.75 11.34 185 1029852 8619 78705732
Knee operation 18.74 11.34 135 1029902 5731 78708620
Acute myelomonocytic leukaemia 18.70 11.34 22 1030015 302 78714049
Galactorrhoea 18.69 11.34 12 1030025 3634 78710717
Splenic infection fungal 18.68 11.34 14 1030023 103 78714248
Anal stenosis 18.62 11.34 27 1030010 460 78713891
Occult blood positive 18.61 11.34 38 1029999 6845 78707506
Osteosarcoma 18.60 11.34 24 1030013 364 78713987
Transplant dysfunction 18.57 11.34 41 1029996 7180 78707171
Acute psychosis 18.53 11.34 16 1030021 4164 78710187
Essential hypertension 18.51 11.34 31 1030006 6022 78708329
Major depression 18.50 11.34 57 1029980 8923 78705428
Breast abscess 18.47 11.34 51 1029986 1415 78712936
Snoring 18.45 11.34 27 1030010 5539 78708812
Rhonchi 18.45 11.34 15 1030022 4021 78710330
Autoimmune lymphoproliferative syndrome 18.43 11.34 17 1030020 172 78714179
Cystitis bacterial 18.43 11.34 33 1030004 677 78713674
Reversible airways obstruction 18.40 11.34 3 1030034 2173 78712178
Cholestatic liver injury 18.39 11.34 22 1030015 4919 78709432
Eczema infected 18.32 11.34 12 1030025 69 78714282
Renal disorder 18.31 11.34 409 1029628 41696 78672655
Anaplastic large cell lymphoma T- and null-cell types 18.26 11.34 15 1030022 128 78714223
Bone sarcoma 18.19 11.34 13 1030024 88 78714263
Pertussis 18.18 11.34 37 1030000 838 78713513
Nausea 18.14 11.34 11704 1018333 945492 77768859
Leukodystrophy 18.13 11.34 9 1030028 27 78714324
Brachiocephalic artery stenosis 18.13 11.34 9 1030028 27 78714324
Acanthosis 18.12 11.34 27 1030010 472 78713879
Schizoaffective disorder 18.12 11.34 3 1030034 2149 78712202
Local reaction 18.10 11.34 30 1030007 577 78713774
Meningitis coccidioides 18.04 11.34 10 1030027 40 78714311
Palmoplantar keratoderma 18.02 11.34 13 1030024 3703 78710648
Guttate psoriasis 18.02 11.34 26 1030011 441 78713910
Lower respiratory tract infection viral 17.98 11.34 45 1029992 1175 78713176
Oligoarthritis 17.96 11.34 33 1030004 691 78713660
Application site rash 17.89 11.34 3 1030034 2129 78712222
Peritonsillar abscess 17.89 11.34 38 1029999 888 78713463
Vasogenic cerebral oedema 17.88 11.34 51 1029986 1442 78712909
Large intestine anastomosis 17.85 11.34 13 1030024 91 78714260
Rotator cuff repair 17.85 11.34 59 1029978 1811 78712540
Oesophageal carcinoma 17.80 11.34 78 1029959 11006 78703345
Synovial rupture 17.77 11.34 23 1030014 350 78714001
Genital infection 17.76 11.34 17 1030020 181 78714170
Polychondritis 17.74 11.34 29 1030008 551 78713800
Hepatitis B 17.70 11.34 175 1029862 8157 78706194
Osteosarcoma recurrent 17.68 11.34 10 1030027 42 78714309
Diabetic retinopathy 17.67 11.34 9 1030028 3097 78711254
Lymphocyte percentage decreased 17.64 11.34 23 1030014 4953 78709398
Ocular lymphoma 17.63 11.34 13 1030024 93 78714258
Gingival ulceration 17.62 11.34 39 1029998 938 78713413
Strongyloidiasis 17.62 11.34 98 1029939 3800 78710551
Suicidal behaviour 17.60 11.34 10 1030027 3237 78711114
Steroid dependence 17.59 11.34 74 1029963 2556 78711795
Appetite disorder 17.50 11.34 47 1029990 7692 78706659
Femur fracture 17.47 11.34 637 1029400 38015 78676336
Renal cell carcinoma 17.47 11.34 145 1029892 6433 78707918
Skin infection 17.45 11.34 332 1029705 17913 78696438
Device alarm issue 17.39 11.34 3 1030034 2086 78712265
Growth retardation 17.39 11.34 60 1029977 1883 78712468
Product taste abnormal 17.36 11.34 4 1030033 2267 78712084
Lupus nephritis 17.36 11.34 81 1029956 2927 78711424
Flank pain 17.35 11.34 168 1029869 19676 78694675
Staphylococcal sepsis 17.33 11.34 277 1029760 14449 78699902
Cerebellar haemorrhage 17.31 11.34 8 1030029 2912 78711439
Nail pitting 17.29 11.34 24 1030013 392 78713959
Large granular lymphocytosis 17.29 11.34 23 1030014 360 78713991
Pseudomonas test positive 17.29 11.34 58 1029979 1794 78712557
Hepatitis fulminant 17.26 11.34 43 1029994 7219 78707132
Differential white blood cell count abnormal 17.26 11.34 3 1030034 2074 78712277
Pupillary reflex impaired 17.24 11.34 11 1030026 3342 78711009
Peripheral coldness 17.20 11.34 128 1029909 15842 78698509
Multiple organ dysfunction syndrome 17.20 11.34 1328 1028709 118918 78595433
Urine output increased 17.20 11.34 4 1030033 2252 78712099
Disseminated toxoplasmosis 17.14 11.34 18 1030019 216 78714135
Catheter site pain 17.09 11.34 27 1030010 5369 78708982
Mood swings 17.09 11.34 169 1029868 19711 78694640
Persecutory delusion 17.09 11.34 23 1030014 4886 78709465
Neoscytalidium infection 17.07 11.34 7 1030030 11 78714340
Facial paralysis 17.04 11.34 374 1029663 20698 78693653
Prostate cancer stage IV 17.03 11.34 5 1030032 2409 78711942
Intra-abdominal haematoma 17.02 11.34 8 1030029 2883 78711468
Scab 16.94 11.34 210 1029827 10362 78703989
Infusion site extravasation 16.93 11.34 70 1029967 10038 78704313
Rotator cuff syndrome 16.92 11.34 266 1029771 13829 78700522
Self-medication 16.91 11.34 25 1030012 5107 78709244
Perineal necrosis 16.91 11.34 14 1030023 121 78714230
Oral mucosal roughening 16.87 11.34 8 1030029 21 78714330
Injection site hypersensitivity 16.85 11.34 59 1029978 1866 78712485
Feeling jittery 16.83 11.34 97 1029940 12744 78701607
Skin neoplasm excision 16.83 11.34 40 1029997 1010 78713341
Hepatic steato-fibrosis 16.81 11.34 5 1030032 0 78714351
Oesophageal stenosis 16.80 11.34 105 1029932 4249 78710102
Parakeratosis 16.78 11.34 23 1030014 371 78713980
Pneumocystis jirovecii infection 16.75 11.34 78 1029959 2816 78711535
Abdominal pain lower 16.75 11.34 299 1029738 31483 78682868
Femoroacetabular impingement 16.70 11.34 7 1030030 12 78714339
Night sweats 16.65 11.34 828 1029209 51267 78663084
Malignant mediastinal neoplasm 16.62 11.34 48 1029989 1367 78712984
Nasal septum perforation 16.62 11.34 33 1030004 734 78713617
Cystitis viral 16.59 11.34 32 1030005 696 78713655
Acute monocytic leukaemia 16.56 11.34 27 1030010 512 78713839
Philadelphia chromosome positive 16.56 11.34 31 1030006 659 78713692
Herpes zoster meningitis 16.52 11.34 16 1030021 173 78714178
Bezoar 16.51 11.34 7 1030030 2681 78711670
Alcohol withdrawal syndrome 16.50 11.34 3 1030034 2008 78712343
Tic 16.47 11.34 9 1030028 2977 78711374
Frequent bowel movements 16.47 11.34 499 1029538 29040 78685311
Cardiovascular disorder 16.44 11.34 151 1029886 17874 78696477
Intervertebral disc degeneration 16.42 11.34 291 1029746 15494 78698857
Presbyacusis 16.37 11.34 73 1029964 2587 78711764
Metastases to central nervous system 16.35 11.34 134 1029903 16241 78698110
Sluggishness 16.35 11.34 38 1029999 6534 78707817
Bronchiolitis obliterans syndrome 16.30 11.34 21 1030016 318 78714033
PO2 decreased 16.25 11.34 9 1030028 2954 78711397
Arthritis enteropathic 16.22 11.34 20 1030017 289 78714062
Precancerous cells present 16.22 11.34 43 1029994 1164 78713187
Quadriplegia 16.22 11.34 86 1029951 3274 78711077
Immunisation 16.21 11.34 4 1030033 2163 78712188
Deafness neurosensory 16.21 11.34 148 1029889 6750 78707601
Cervical dysplasia 16.20 11.34 63 1029974 2098 78712253
Bone marrow transplant rejection 16.19 11.34 19 1030018 260 78714091
Brain injury 16.19 11.34 85 1029952 11432 78702919
Androgenetic alopecia 16.17 11.34 15 1030022 153 78714198
Precursor T-lymphoblastic lymphoma/leukaemia 16.15 11.34 12 1030025 87 78714264
Tongue neoplasm 16.15 11.34 12 1030025 87 78714264
Vaginal haemorrhage 16.13 11.34 192 1029845 21625 78692726
Nodal arrhythmia 16.12 11.34 3 1030034 1975 78712376
Anaplastic thyroid cancer 16.12 11.34 8 1030029 24 78714327
Tendon graft 16.09 11.34 6 1030031 6 78714345
Nasal mucosal ulcer 16.09 11.34 6 1030031 6 78714345
Bronchioloalveolar carcinoma 16.05 11.34 10 1030027 52 78714299
White matter lesion 16.02 11.34 60 1029977 1962 78712389
Walking aid user 16.01 11.34 201 1029836 9947 78704404
Contraindication to vaccination 16.00 11.34 17 1030020 207 78714144
Graft versus host disease in lung 16.00 11.34 36 1030001 876 78713475
Anal squamous cell carcinoma 15.99 11.34 28 1030009 564 78713787
Post transplant lymphoproliferative disorder 15.98 11.34 222 1029815 11242 78703109
Asthma-chronic obstructive pulmonary disease overlap syndrome 15.97 11.34 11 1030026 3210 78711141
Cerebral fungal infection 15.97 11.34 24 1030013 423 78713928
Blood thyroid stimulating hormone decreased 15.93 11.34 31 1030006 5685 78708666
Coagulopathy 15.88 11.34 349 1029688 35657 78678694
Subcutaneous haematoma 15.87 11.34 8 1030029 2769 78711582
Ecchymosis 15.85 11.34 123 1029914 15083 78699268
Large intestinal stenosis 15.82 11.34 76 1029961 2780 78711571
Peripheral vascular disorder 15.82 11.34 52 1029985 7978 78706373
Bipolar disorder 15.82 11.34 49 1029988 7658 78706693
Total lung capacity increased 15.78 11.34 5 1030032 2293 78712058
Squamous cell carcinoma of the tongue 15.78 11.34 32 1030005 723 78713628
Bladder transitional cell carcinoma 15.77 11.34 72 1029965 2578 78711773
Tongue disorder 15.75 11.34 261 1029776 13714 78700637
Meningitis enterococcal 15.72 11.34 12 1030025 91 78714260
Oral toxicity 15.71 11.34 7 1030030 15 78714336
Chronic sinusitis 15.71 11.34 101 1029936 12925 78701426
Plasmablastic lymphoma 15.65 11.34 26 1030011 501 78713850
Deafness 15.64 11.34 369 1029668 20668 78693683
Follicular lymphoma 15.64 11.34 22 1030015 364 78713987
Myositis 15.63 11.34 165 1029872 19003 78695348
Affective disorder 15.62 11.34 55 1029982 8264 78706087
SAPHO syndrome 15.61 11.34 23 1030014 398 78713953
Thyroiditis 15.60 11.34 22 1030015 4583 78709768
Gastrointestinal sounds abnormal 15.57 11.34 29 1030008 5406 78708945
Disease susceptibility 15.52 11.34 20 1030017 303 78714048
Blood parathyroid hormone increased 15.50 11.34 13 1030024 3432 78710919
Intestinal polyp 15.50 11.34 61 1029976 2043 78712308
Pseudopolyp 15.49 11.34 24 1030013 435 78713916
Economic problem 15.48 11.34 5 1030032 2265 78712086
Perineal infection 15.45 11.34 33 1030004 774 78713577
Bone abscess 15.45 11.34 25 1030012 471 78713880
Nodular melanoma 15.43 11.34 15 1030022 163 78714188
Erythema induratum 15.43 11.34 16 1030021 189 78714162
Spinal meningioma benign 15.42 11.34 12 1030025 94 78714257
Retroperitoneal haematoma 15.40 11.34 28 1030009 5269 78709082
Fracture delayed union 15.40 11.34 61 1029976 2049 78712302
Malignant melanoma stage I 15.39 11.34 14 1030023 139 78714212
Tetany 15.38 11.34 8 1030029 2720 78711631
Infectious thyroiditis 15.37 11.34 13 1030024 116 78714235
Gliosis 15.37 11.34 25 1030012 473 78713878
Chloroma 15.34 11.34 32 1030005 738 78713613
Hepatic candidiasis 15.33 11.34 11 1030026 75 78714276
Mucosal erosion 15.33 11.34 65 1029972 2253 78712098
Lupus vasculitis 15.31 11.34 27 1030010 547 78713804
Premature rupture of membranes 15.27 11.34 18 1030019 4051 78710300
Bladder transitional cell carcinoma recurrent 15.23 11.34 14 1030023 141 78714210
Ear infection bacterial 15.23 11.34 14 1030023 141 78714210
Pulmonary granuloma 15.23 11.34 61 1029976 2060 78712291
Hypokinesia 15.17 11.34 165 1029872 18895 78695456
Hepatic infection fungal 15.15 11.34 17 1030020 221 78714130
Lung squamous cell carcinoma stage I 15.13 11.34 7 1030030 17 78714334
Hypermobility syndrome 15.12 11.34 26 1030011 516 78713835
Liver transplant 15.11 11.34 21 1030016 4402 78709949
Tuberculosis of eye 15.10 11.34 11 1030026 77 78714274
Hypopituitarism 15.08 11.34 13 1030024 3386 78710965
Injection site vesicles 15.08 11.34 79 1029958 2993 78711358
Inflammatory pseudotumour 15.07 11.34 10 1030027 59 78714292
Hypercholesterolaemia 15.07 11.34 398 1029639 22697 78691654
Thiopurine methyltransferase decreased 15.04 11.34 21 1030016 345 78714006
Minimal residual disease 15.04 11.34 25 1030012 482 78713869
Dyspnoea paroxysmal nocturnal 15.03 11.34 5 1030032 2223 78712128
Encephalopathy 15.02 11.34 714 1029323 66683 78647668
Peritonitis 15.02 11.34 263 1029774 27773 78686578
Amyloidosis 14.99 11.34 72 1029965 2634 78711717
Premature baby 14.98 11.34 16 1030021 3764 78710587
Herpes zoster infection neurological 14.98 11.34 18 1030019 253 78714098
Food intolerance 14.97 11.34 93 1029944 3755 78710596
Wound infection 14.95 11.34 411 1029626 23580 78690771
Plasmacytoma 14.95 11.34 21 1030016 4382 78709969
Haemarthrosis 14.95 11.34 33 1030004 5779 78708572
Loss of libido 14.95 11.34 8 1030029 2677 78711674
Red cell distribution width decreased 14.94 11.34 59 1029978 1979 78712372
Viraemia 14.93 11.34 75 1029962 2794 78711557
Cholangitis 14.93 11.34 100 1029937 12676 78701675
Pericarditis tuberculous 14.93 11.34 12 1030025 99 78714252
Perirectal abscess 14.89 11.34 59 1029978 1982 78712369
Soft tissue infection 14.88 11.34 94 1029943 3818 78710533
Capnocytophaga infection 14.86 11.34 13 1030024 122 78714229
Genital herpes zoster 14.86 11.34 7 1030030 18 78714333
Pleural thickening 14.86 11.34 77 1029960 2905 78711446
Combined immunodeficiency 14.83 11.34 12 1030025 100 78714251
Optic ischaemic neuropathy 14.83 11.34 10 1030027 2951 78711400
Stoma site discharge 14.83 11.34 5 1030032 2204 78712147
Intervertebral discitis 14.79 11.34 110 1029927 4718 78709633
Myxoid liposarcoma 14.79 11.34 6 1030031 9 78714342
Furuncle 14.78 11.34 156 1029881 7398 78706953
Anovulatory cycle 14.78 11.34 13 1030024 123 78714228
Bronchopulmonary aspergillosis 14.78 11.34 385 1029652 21909 78692442
Marginal zone lymphoma 14.77 11.34 11 1030026 80 78714271
Blood creatine phosphokinase MB increased 14.76 11.34 9 1030028 2802 78711549
Acral lentiginous melanoma 14.72 11.34 9 1030028 45 78714306
Viral load increased 14.71 11.34 10 1030027 2938 78711413
Uterine disorder 14.68 11.34 62 1029975 2145 78712206
Abdominal pain upper 14.68 11.34 2605 1027432 221214 78493137
Rash papular 14.67 11.34 197 1029840 21719 78692632
Subacute combined cord degeneration 14.67 11.34 20 1030017 321 78714030
Limb mass 14.65 11.34 88 1029949 3511 78710840
Skin atrophy 14.63 11.34 125 1029912 5593 78708758
Diabetic neuropathy 14.63 11.34 37 1030000 6179 78708172
Temperature intolerance 14.57 11.34 70 1029967 9635 78704716
Birdshot chorioretinopathy 14.56 11.34 10 1030027 63 78714288
Metatarsalgia 14.47 11.34 17 1030020 233 78714118
HLA-B*27 positive 14.47 11.34 12 1030025 104 78714247
Exposed bone in jaw 14.46 11.34 16 1030021 3704 78710647
Candida test positive 14.45 11.34 39 1029998 1067 78713284
Nocardiosis 14.45 11.34 124 1029913 5555 78708796
Nephrosclerosis 14.45 11.34 3 1030034 1827 78712524
Ligament calcification 14.43 11.34 16 1030021 205 78714146
Glottis carcinoma 14.42 11.34 6 1030031 10 78714341
Endotracheal intubation 14.41 11.34 24 1030013 4673 78709678
Device infusion issue 14.38 11.34 6 1030031 2320 78712031
Secondary amyloidosis 14.37 11.34 16 1030021 206 78714145
Genital abscess 14.37 11.34 16 1030021 206 78714145
Accidental overdose 14.36 11.34 395 1029642 39186 78675165
Neutrophil percentage increased 14.35 11.34 24 1030013 4665 78709686
Petit mal epilepsy 14.34 11.34 33 1030004 5694 78708657
Blood creatine increased 14.31 11.34 68 1029969 9387 78704964
Pneumonia viral 14.28 11.34 181 1029856 8977 78705374
Meningitis listeria 14.28 11.34 38 1029999 1031 78713320
Hypogammaglobulinaemia 14.28 11.34 241 1029796 12710 78701641
Foreign body sensation in eyes 14.27 11.34 5 1030032 2152 78712199
Allergy to vaccine 14.26 11.34 16 1030021 208 78714143
Vasculitic rash 14.25 11.34 61 1029976 2123 78712228
Injection site papule 14.25 11.34 35 1030002 903 78713448
Facial paresis 14.24 11.34 121 1029916 5405 78708946
Spinal cord compression 14.21 11.34 39 1029998 6338 78708013
Cervix carcinoma stage 0 14.19 11.34 17 1030020 238 78714113
Histiocytic sarcoma 14.19 11.34 10 1030027 66 78714285
Spinal cord disorder 14.17 11.34 54 1029983 1781 78712570
Hip surgery 14.16 11.34 81 1029956 3174 78711177
Pharyngeal inflammation 14.15 11.34 37 1030000 993 78713358
Scarlet fever 14.14 11.34 13 1030024 131 78714220
Cytomegalovirus enteritis 14.13 11.34 32 1030005 782 78713569
Malignant melanoma in situ 14.13 11.34 66 1029971 2386 78711965
Non-cardiac chest pain 14.12 11.34 69 1029968 9455 78704896
Muscle strength abnormal 14.10 11.34 18 1030019 270 78714081
Arthroscopy 14.09 11.34 25 1030012 509 78713842
Pancreatic calcification 14.09 11.34 17 1030020 240 78714111
Borrelia infection 14.09 11.34 17 1030020 240 78714111
Stem cell transplant 14.09 11.34 89 1029948 3615 78710736
Surgery 14.09 11.34 537 1029500 32229 78682122
Infectious mononucleosis 14.08 11.34 58 1029979 1984 78712367
Intussusception 14.05 11.34 40 1029997 1130 78713221
Tinea versicolour 14.04 11.34 20 1030017 335 78714016
Cytogenetic abnormality 14.04 11.34 39 1029998 1086 78713265
Injection site induration 14.03 11.34 191 1029846 9628 78704723
Pulmonary function test decreased 14.00 11.34 51 1029986 7586 78706765
Loss of control of legs 13.99 11.34 4 1030033 1961 78712390
Nerve injury 13.96 11.34 184 1029853 9208 78705143
Arrhythmia supraventricular 13.96 11.34 5 1030032 2122 78712229
Prostate cancer stage III 13.92 11.34 3 1030034 1780 78712571
Myelomalacia 13.91 11.34 13 1030024 134 78714217
Sputum culture positive 13.90 11.34 17 1030020 3764 78710587
Purulent discharge 13.90 11.34 129 1029908 5910 78708441
Herpes ophthalmic 13.90 11.34 47 1029990 1460 78712891
Leptotrichia infection 13.84 11.34 9 1030028 51 78714300
Skin dystrophy 13.84 11.34 10 1030027 69 78714282
Heavy menstrual bleeding 13.83 11.34 115 1029922 13896 78700455
Vulval cancer 13.82 11.34 25 1030012 517 78713834
Cytomegalovirus hepatitis 13.81 11.34 31 1030006 753 78713598
Injection site discomfort 13.79 11.34 114 1029923 5052 78709299
Sinus arrhythmia 13.78 11.34 5 1030032 2105 78712246
Carotid intima-media thickness increased 13.76 11.34 11 1030026 90 78714261
Torus fracture 13.76 11.34 11 1030026 90 78714261
Liver sarcoidosis 13.74 11.34 6 1030031 12 78714339
Rectal cancer 13.73 11.34 85 1029952 3428 78710923
Chimerism 13.71 11.34 18 1030019 278 78714073
Hiatus hernia 13.70 11.34 215 1029822 23097 78691254
Hypergammaglobulinaemia 13.68 11.34 30 1030007 717 78713634
Therapeutic response delayed 13.67 11.34 39 1029998 1103 78713248
Tenosynovitis stenosans 13.66 11.34 77 1029960 3001 78711350
Cardiac valve disease 13.64 11.34 34 1030003 5707 78708644
Implant site pain 13.64 11.34 5 1030032 2092 78712259
Fanconi syndrome acquired 13.63 11.34 9 1030028 2685 78711666
Pneumonia fungal 13.63 11.34 212 1029825 10998 78703353
Resuscitation 13.62 11.34 7 1030030 2397 78711954
Psychogenic seizure 13.62 11.34 4 1030033 1927 78712424
Oesophagitis 13.61 11.34 226 1029811 24063 78690288
Induced abortion failed 13.60 11.34 15 1030022 191 78714160
Incision site pain 13.59 11.34 10 1030027 2820 78711531
Genital ulceration 13.59 11.34 38 1029999 1062 78713289
Stoma site erythema 13.58 11.34 3 1030034 1750 78712601
Overwork 13.58 11.34 9 1030028 53 78714298
Biliary dyskinesia 13.57 11.34 8 1030029 2537 78711814
Acquired claw toe 13.57 11.34 11 1030026 92 78714259
Apathy 13.51 11.34 105 1029932 12872 78701479
Carbon dioxide increased 13.49 11.34 6 1030031 2234 78712117
Application site irritation 13.48 11.34 3 1030034 1741 78712610
Anti-cyclic citrullinated peptide antibody 13.47 11.34 125 1029912 5727 78708624
Torticollis 13.45 11.34 7 1030030 2380 78711971
Infected bite 13.45 11.34 55 1029982 1875 78712476
Myocarditis bacterial 13.45 11.34 4 1030033 0 78714351
Blau syndrome 13.45 11.34 4 1030033 0 78714351
Necrotising fasciitis staphylococcal 13.45 11.34 4 1030033 0 78714351
Leukaemia monocytic 13.45 11.34 4 1030033 0 78714351
Gestational trophoblastic tumour 13.45 11.34 4 1030033 0 78714351
Merkel cell polyomavirus infection 13.45 11.34 4 1030033 0 78714351
Device failure 13.43 11.34 39 1029998 6222 78708129
Concomitant disease progression 13.43 11.34 15 1030022 3458 78710893
Natural killer cell count increased 13.43 11.34 6 1030031 13 78714338
Large intestinal ulcer 13.42 11.34 107 1029930 4690 78709661
Spinal rod insertion 13.41 11.34 5 1030032 5 78714346
Bladder neck operation 13.41 11.34 5 1030032 5 78714346
Yolk sac tumour site unspecified 13.41 11.34 5 1030032 5 78714346
Cardiolipin antibody 13.41 11.34 5 1030032 5 78714346
Herpes dermatitis 13.38 11.34 11 1030026 94 78714257
Stomatitis necrotising 13.37 11.34 15 1030022 195 78714156
Psychiatric decompensation 13.36 11.34 19 1030018 3944 78710407
Drug dose omission by device 13.36 11.34 39 1029998 6211 78708140
Contrast media reaction 13.36 11.34 5 1030032 2065 78712286
Blood testosterone decreased 13.35 11.34 7 1030030 2370 78711981
Meningitis viral 13.34 11.34 56 1029981 1932 78712419
Venous injury 13.34 11.34 31 1030006 771 78713580
Muscle swelling 13.34 11.34 32 1030005 813 78713538
Infusion site reaction 13.33 11.34 84 1029953 3409 78710942
Respiratory rate decreased 13.30 11.34 30 1030007 5213 78709138
Cerebellar tumour 13.29 11.34 11 1030026 95 78714256
Cheilitis 13.27 11.34 116 1029921 5225 78709126
Bronchiectasis 13.25 11.34 381 1029656 22005 78692346
Lipoma 13.23 11.34 76 1029961 2983 78711368
Post transplant distal limb syndrome 13.22 11.34 26 1030011 574 78713777
Intraventricular haemorrhage 13.20 11.34 27 1030010 4860 78709491
Decreased interest 13.20 11.34 17 1030020 3680 78710671
Pyopneumothorax 13.19 11.34 10 1030027 75 78714276
Light chain analysis increased 13.19 11.34 3 1030034 1715 78712636
Hypertensive emergency 13.17 11.34 10 1030027 2775 78711576
Cauda equina syndrome 13.15 11.34 44 1029993 1359 78712992
Attention deficit hyperactivity disorder 13.12 11.34 14 1030023 3295 78711056
Urosepsis 13.11 11.34 252 1029785 26243 78688108
Eye movement disorder 13.09 11.34 56 1029981 7955 78706396
Enuresis 13.08 11.34 13 1030024 3163 78711188
Multifocal motor neuropathy 13.08 11.34 8 1030029 40 78714311
T-cell lymphoma refractory 13.06 11.34 9 1030028 57 78714294
Right ventricular dysfunction 13.06 11.34 9 1030028 2626 78711725
Tension 13.06 11.34 23 1030014 4381 78709970
Sensory disturbance 13.03 11.34 128 1029909 14949 78699402
Injection related reaction 13.01 11.34 36 1030001 1000 78713351
Breast mass 12.99 11.34 139 1029898 6615 78707736
Purulent pericarditis 12.98 11.34 10 1030027 77 78714274
Transplant evaluation 12.95 11.34 3 1030034 1694 78712657
Monoclonal B-cell lymphocytosis 12.94 11.34 9 1030028 58 78714293
Corneal oedema 12.92 11.34 9 1030028 2611 78711740
Ischaemic hepatitis 12.92 11.34 17 1030020 3647 78710704
Hepatic cytolysis 12.90 11.34 260 1029777 26891 78687460
Fontanelle bulging 12.85 11.34 6 1030031 15 78714336
Anti-saccharomyces cerevisiae antibody 12.85 11.34 6 1030031 15 78714336
Nasal cavity cancer 12.84 11.34 16 1030021 234 78714117
Mycotic allergy 12.82 11.34 46 1029991 1473 78712878
Illness 12.81 11.34 729 1029308 45782 78668569
Renal tubular atrophy 12.81 11.34 4 1030033 1852 78712499
Ankle brachial index decreased 12.78 11.34 10 1030027 79 78714272
Lower respiratory tract congestion 12.78 11.34 92 1029945 3905 78710446
Lymphocele 12.78 11.34 3 1030034 1678 78712673
Monoclonal gammopathy 12.77 11.34 33 1030004 879 78713472
Oral lichen planus 12.74 11.34 31 1030006 795 78713556
Cryptococcosis 12.71 11.34 83 1029954 3410 78710941
Blood fibrinogen decreased 12.71 11.34 55 1029982 1924 78712427
Joint fluid drainage 12.70 11.34 18 1030019 300 78714051
Bone graft 12.69 11.34 29 1030008 713 78713638
Chronic myeloid leukaemia 12.69 11.34 86 1029951 3578 78710773
Cystic fibrosis 12.69 11.34 19 1030018 3861 78710490
Granulomatous liver disease 12.67 11.34 42 1029995 1291 78713060
Joint surgery 12.66 11.34 18 1030019 301 78714050
Endometriosis 12.65 11.34 86 1029951 3582 78710769
PCO2 increased 12.64 11.34 4 1030033 1836 78712515
Lentigo 12.64 11.34 23 1030014 478 78713873
Testicular seminoma (pure) 12.63 11.34 8 1030029 43 78714308
Lichen myxoedematosus 12.63 11.34 8 1030029 43 78714308
Invasive breast carcinoma 12.63 11.34 24 1030013 516 78713835
Immune recovery uveitis 12.63 11.34 7 1030030 28 78714323
Phototherapy 12.63 11.34 7 1030030 28 78714323
Trichosporon infection 12.63 11.34 35 1030002 973 78713378
Skin reaction 12.62 11.34 284 1029753 15784 78698567
Back disorder 12.60 11.34 215 1029822 11363 78702988
Portal fibrosis 12.60 11.34 26 1030011 595 78713756
Hyperkeratosis 12.59 11.34 155 1029882 7635 78706716
Hypertriglyceridaemia 12.59 11.34 233 1029804 12507 78701844
Tissue injury 12.59 11.34 9 1030028 61 78714290
Follicle centre lymphoma, follicular grade I, II, III 12.59 11.34 10 1030027 81 78714270
Respiratory tract ulceration 12.58 11.34 6 1030031 16 78714335
Adult T-cell lymphoma/leukaemia recurrent 12.58 11.34 6 1030031 16 78714335
Joint abscess 12.57 11.34 24 1030013 518 78713833
Ejection fraction abnormal 12.55 11.34 8 1030029 2432 78711919
Stress at work 12.53 11.34 38 1029999 1113 78713238
International normalised ratio fluctuation 12.53 11.34 82 1029955 3372 78710979
Internal haemorrhage 12.52 11.34 65 1029972 8768 78705583
Complicated appendicitis 12.52 11.34 12 1030025 128 78714223
Aphasia 12.51 11.34 485 1029552 46247 78668104
Angiotensin converting enzyme increased 12.51 11.34 13 1030024 154 78714197
Urticarial vasculitis 12.50 11.34 25 1030012 559 78713792
Emotional disorder 12.49 11.34 122 1029915 14265 78700086
Pulse waveform abnormal 12.49 11.34 10 1030027 82 78714269
Squamous cell carcinoma of the cervix 12.48 11.34 16 1030021 241 78714110
Soft tissue disorder 12.48 11.34 83 1029954 3432 78710919
Osteochondrosis 12.45 11.34 55 1029982 1941 78712410
DNA antibody positive 12.45 11.34 18 1030019 306 78714045
Derealisation 12.42 11.34 3 1030034 1646 78712705
Product administered at inappropriate site 12.41 11.34 20 1030017 3945 78710406
Embolism 12.38 11.34 118 1029919 13864 78700487
Gastrointestinal lymphoma 12.38 11.34 13 1030024 156 78714195
Meningitis chemical 12.36 11.34 15 1030022 213 78714138
Gastric neoplasm 12.35 11.34 19 1030018 342 78714009
Haematocolpos 12.35 11.34 8 1030029 45 78714306
Loss of employment 12.34 11.34 66 1029971 2521 78711830
Expired product administered 12.33 11.34 48 1029989 7003 78707348
Cryptococcus test positive 12.33 11.34 6 1030031 17 78714334
Hepatic necrosis 12.33 11.34 68 1029969 9032 78705319
Central nervous system necrosis 12.32 11.34 17 1030020 276 78714075
Metastases to liver 12.32 11.34 275 1029762 28039 78686312
Shoulder operation 12.31 11.34 69 1029968 2683 78711668
Vitreous floaters 12.31 11.34 50 1029987 7206 78707145
Vascular stent thrombosis 12.30 11.34 18 1030019 3692 78710659
Mediastinal mass 12.29 11.34 25 1030012 566 78713785
Libido decreased 12.27 11.34 32 1030005 5289 78709062
Disorganised speech 12.24 11.34 6 1030031 2111 78712240
Short stature 12.24 11.34 28 1030009 689 78713662
Discontinued product administered 12.21 11.34 10 1030027 85 78714266
Bursa disorder 12.19 11.34 16 1030021 247 78714104
Oral infection 12.19 11.34 120 1029917 5587 78708764
Mean cell haemoglobin concentration abnormal 12.19 11.34 13 1030024 159 78714192
Pulmonary cavitation 12.19 11.34 48 1029989 1608 78712743
Facial bones fracture 12.15 11.34 30 1030007 5052 78709299
Herpes simplex meningoencephalitis 12.14 11.34 9 1030028 65 78714286
Ear canal stenosis 12.14 11.34 5 1030032 8 78714343
Squamous cell carcinoma of the vagina 12.14 11.34 5 1030032 8 78714343
Conjunctival deposit 12.14 11.34 5 1030032 8 78714343
Intestinal malrotation 12.14 11.34 5 1030032 8 78714343
Malignant syphilis 12.14 11.34 5 1030032 8 78714343
Skin tightness 12.14 11.34 34 1030003 5488 78708863
Gastritis erosive 12.14 11.34 86 1029951 10761 78703590
Pain in jaw 12.13 11.34 480 1029557 45671 78668680
Inflammatory myofibroblastic tumour 12.13 11.34 13 1030024 160 78714191
Glioblastoma 12.12 11.34 48 1029989 1612 78712739
Large intestinal haemorrhage 12.12 11.34 11 1030026 2794 78711557
Carpal tunnel decompression 12.10 11.34 27 1030010 653 78713698
Human herpesvirus 8 infection 12.10 11.34 39 1029998 1181 78713170
Ossicle disorder 12.09 11.34 7 1030030 31 78714320
Cyclic neutropenia 12.09 11.34 6 1030031 18 78714333
Dysphoria 12.08 11.34 27 1030010 4707 78709644
Mucosal infection 12.06 11.34 23 1030014 496 78713855
Haemorrhoidal haemorrhage 12.05 11.34 46 1029991 6749 78707602
Abortion induced 12.05 11.34 49 1029988 7060 78707291
Middle insomnia 12.04 11.34 141 1029896 15928 78698423
Acute interstitial pneumonitis 12.04 11.34 39 1029998 1184 78713167
Normochromic normocytic anaemia 12.03 11.34 55 1029982 7672 78706679
Thalamus haemorrhage 12.02 11.34 4 1030033 1778 78712573
Infusion site infection 12.01 11.34 4 1030033 1777 78712574
Physical assault 12.00 11.34 3 1030034 1608 78712743
Oxygen therapy 11.99 11.34 11 1030026 2779 78711572
Blood lactate dehydrogenase increased 11.97 11.34 400 1029637 38770 78675581
Bruxism 11.96 11.34 21 1030016 4005 78710346
Throat clearing 11.96 11.34 10 1030027 2644 78711707
B-cell lymphoma stage IV 11.93 11.34 10 1030027 88 78714263
Mixed connective tissue disease 11.90 11.34 18 1030019 319 78714032
Blood chloride increased 11.89 11.34 31 1030006 5125 78709226
Demyelinating polyneuropathy 11.88 11.34 49 1029988 1677 78712674
Product storage error 11.88 11.34 284 1029753 15942 78698409
Adenoviral haemorrhagic cystitis 11.87 11.34 23 1030014 502 78713849
Pneumonia cytomegaloviral 11.87 11.34 107 1029930 4862 78709489
Ulcerative keratitis 11.85 11.34 85 1029952 3604 78710747
Diverticulum intestinal haemorrhagic 11.85 11.34 21 1030016 3990 78710361
Multiple-drug resistance 11.83 11.34 66 1029971 8742 78705609
Conjunctivitis bacterial 11.82 11.34 21 1030016 428 78713923
Scar excision 11.82 11.34 9 1030028 68 78714283
Infusion site mass 11.80 11.34 3 1030034 1590 78712761
Vulval cancer stage III 11.78 11.34 5 1030032 9 78714342
Intestinal stenosis 11.77 11.34 86 1029951 3668 78710683
Cutaneous T-cell lymphoma stage I 11.76 11.34 7 1030030 33 78714318
Blood beta-D-glucan increased 11.75 11.34 24 1030013 545 78713806
PO2 increased 11.75 11.34 3 1030034 1585 78712766
CSF protein increased 11.72 11.34 39 1029998 1201 78713150
Otitis media acute 11.72 11.34 41 1029996 1296 78713055
Neutropenic colitis 11.71 11.34 119 1029918 5588 78708763
Pyuria 11.71 11.34 8 1030029 2344 78712007
Investigation 11.70 11.34 8 1030029 2343 78712008
Eyelid exfoliation 11.69 11.34 12 1030025 140 78714211
Eyelid ptosis 11.67 11.34 89 1029948 10955 78703396
Toxoplasmosis 11.66 11.34 67 1029970 2630 78711721
Methaemoglobinaemia 11.64 11.34 35 1030002 5522 78708829
Chronic actinic dermatitis 11.63 11.34 6 1030031 20 78714331
Myopathy 11.63 11.34 191 1029846 20372 78693979
Bedridden 11.62 11.34 220 1029817 11859 78702492
Photopsia 11.62 11.34 33 1030004 5303 78709048
Hyperammonaemic encephalopathy 11.62 11.34 28 1030009 4754 78709597
Dermatitis contact 11.61 11.34 89 1029948 10944 78703407
Frontotemporal dementia 11.61 11.34 25 1030012 590 78713761
Dysphonia 11.60 11.34 608 1029429 56264 78658087
Forced vital capacity decreased 11.60 11.34 4 1030033 1739 78712612
Generalised anxiety disorder 11.58 11.34 7 1030030 2190 78712161
Peripheral ischaemia 11.57 11.34 73 1029964 9384 78704967
Therapeutic product effect increased 11.56 11.34 3 1030034 1568 78712783
Diffuse alveolar damage 11.55 11.34 83 1029954 3521 78710830
White blood cells urine positive 11.52 11.34 40 1029997 6035 78708316
Mucosal atrophy 11.51 11.34 9 1030028 71 78714280
Cranial nerve disorder 11.48 11.34 36 1030001 1074 78713277
Adenocarcinoma of the cervix 11.48 11.34 14 1030023 200 78714151
Allergic oedema 11.47 11.34 29 1030008 762 78713589
Cerebral ischaemia 11.46 11.34 91 1029946 11104 78703247
Necrotising scleritis 11.46 11.34 15 1030022 231 78714120
Carbohydrate antigen 125 increased 11.45 11.34 7 1030030 2177 78712174
Ureterocele 11.45 11.34 5 1030032 10 78714341
Rheumatoid factor quantitative increased 11.45 11.34 5 1030032 10 78714341
Hamartoma 11.45 11.34 5 1030032 10 78714341
Vulvovaginitis streptococcal 11.45 11.34 5 1030032 10 78714341
Limbal stem cell deficiency 11.45 11.34 7 1030030 35 78714316
Rib fracture 11.44 11.34 274 1029763 27673 78686678
Tooth fracture 11.44 11.34 211 1029826 11319 78703032
Aortic valve incompetence 11.44 11.34 74 1029963 9456 78704895
Adenoviral hepatitis 11.43 11.34 32 1030005 895 78713456
Paranasal sinus hypersecretion 11.43 11.34 87 1029950 3759 78710592
Leukaemia 11.42 11.34 122 1029915 5803 78708548
Silicosis 11.42 11.34 6 1030031 21 78714330
Groin abscess 11.39 11.34 45 1029992 1510 78712841
Myasthenia gravis 11.37 11.34 83 1029954 10316 78704035
Mouth swelling 11.37 11.34 40 1029997 6011 78708340
Ligament rupture 11.36 11.34 79 1029958 3315 78711036
Chronic graft versus host disease oral 11.36 11.34 12 1030025 145 78714206
Prothrombin time shortened 11.36 11.34 15 1030022 3213 78711138

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L01BA01 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
ANTIMETABOLITES
Folic acid analogues
ATC L04AX03 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
IMMUNOSUPPRESSANTS
IMMUNOSUPPRESSANTS
Other immunosuppressants
FDA MoA N0000000111 Folic Acid Metabolism Inhibitors
FDA EPC N0000175584 Folate Analog Metabolic Inhibitor
MeSH PA D000019 Abortifacient Agents
MeSH PA D000020 Abortifacient Agents, Nonsteroidal
MeSH PA D000963 Antimetabolites
MeSH PA D000964 Antimetabolites, Antineoplastic
MeSH PA D000970 Antineoplastic Agents
MeSH PA D018501 Antirheumatic Agents
MeSH PA D003879 Dermatologic Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D005493 Folic Acid Antagonists
MeSH PA D007155 Immunologic Factors
MeSH PA D007166 Immunosuppressive Agents
MeSH PA D009676 Noxae
MeSH PA D019384 Nucleic Acid Synthesis Inhibitors
MeSH PA D012102 Reproductive Control Agents
CHEBI has role CHEBI:35221 antimetabolite
CHEBI has role CHEBI:35610 antineoplastic agents
CHEBI has role CHEBI:35705 immunosuppressive agents
CHEBI has role CHEBI:35842 anti-rheumatic drugs
CHEBI has role CHEBI:50177 dermatologic agent
CHEBI has role CHEBI:50683 dihydrofolic acid reductase inhibitors
CHEBI has role CHEBI:50691 abortifacient drug
CHEBI has role CHEBI:59517 DNA synthesis inhibitors

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Psoriasis indication 9014002 DOID:8893
Crohn's disease indication 34000006
Rheumatoid arthritis indication 69896004 DOID:7148
Acute lymphoid leukemia indication 91857003 DOID:9952
Non-Hodgkin's lymphoma indication 118601006
Burkitt's lymphoma indication 118617000
Mycosis fungoides indication 118618005
Psoriatic arthritis indication 156370009 DOID:9008
Plaque psoriasis indication 200965009
Pustular psoriasis indication 200973000
Erythrodermic psoriasis indication 200977004
Malignant tumor of head and/or neck indication 255056009
Osteosarcoma of bone indication 307576001 DOID:3376
Malignant tumor of lung indication 363358000
Juvenile idiopathic arthritis indication 410502007
Juvenile rheumatoid arthritis indication 410795001
Carcinoma of female breast indication 447782002
Gestational trophoblastic neoplasia indication 609519004 DOID:3590
Meningeal Leukemia indication
Polymyositis off-label use 31384009
Vasculitis off-label use 31996006 DOID:865
Psoriasis with arthropathy off-label use 33339001
Systemic lupus erythematosus off-label use 55464009 DOID:9074
Acute myeloid leukemia, disease off-label use 91861009
Acute promyelocytic leukemia, FAB M3 off-label use 110004001
Wegener's granulomatosis off-label use 195353004 DOID:12132
Malignant tumor of urinary bladder off-label use 399326009 DOID:11054
Systemic Dermatomyositis off-label use
Alcoholism contraindication 7200002
Peptic ulcer contraindication 13200003 DOID:750
Dehydration contraindication 34095006
Fibrosis of lung contraindication 51615001 DOID:3770
Acute nephropathy contraindication 58574008
Hepatic failure contraindication 59927004
Stomatitis contraindication 61170000 DOID:9637
Interstitial pneumonia contraindication 64667001
Ulcerative colitis contraindication 64766004 DOID:8577
Leukopenia contraindication 84828003 DOID:615
Kidney disease contraindication 90708001 DOID:557
Disease of liver contraindication 235856003 DOID:409
Anemia contraindication 271737000 DOID:2355
Pregnancy, function contraindication 289908002
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Bone marrow depression contraindication 307762000
Ascites contraindication 389026000
Gastric ulcer contraindication 397825006 DOID:10808
Breastfeeding (mother) contraindication 413712001
Disorder of immune function contraindication 414029004
Pleural Effusions contraindication
Methotrexate Toxicity contraindication




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.61 acidic
pKa2 5.15 acidic
pKa3 12.92 acidic
pKa4 5.73 Basic
pKa5 4.51 Basic
pKa6 1.39 Basic
pKa7 0.75 Basic
pKa8 0.08 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
10MG/0.20ML (10MG/0.20ML) RASUVO MEDEXUS N205776 July 10, 2014 RX SOLUTION SUBCUTANEOUS 8664231 June 1, 2029 SUBCUTANEOUS INJECTION OF METHOTREXATE
12.5MG/0.25ML (12.5MG/0.25ML) RASUVO MEDEXUS N205776 July 10, 2014 RX SOLUTION SUBCUTANEOUS 8664231 June 1, 2029 SUBCUTANEOUS INJECTION OF METHOTREXATE
15MG/0.30ML (15MG/0.30ML) RASUVO MEDEXUS N205776 July 10, 2014 RX SOLUTION SUBCUTANEOUS 8664231 June 1, 2029 SUBCUTANEOUS INJECTION OF METHOTREXATE
17.5MG/0.35ML (17.5MG/0.35ML) RASUVO MEDEXUS N205776 July 10, 2014 RX SOLUTION SUBCUTANEOUS 8664231 June 1, 2029 SUBCUTANEOUS INJECTION OF METHOTREXATE
20MG/0.4ML (20MG/0.4ML) RASUVO MEDEXUS N205776 July 10, 2014 RX SOLUTION SUBCUTANEOUS 8664231 June 1, 2029 SUBCUTANEOUS INJECTION OF METHOTREXATE
22.5MG/0.45ML (22.5MG/0.45ML) RASUVO MEDEXUS N205776 July 10, 2014 RX SOLUTION SUBCUTANEOUS 8664231 June 1, 2029 SUBCUTANEOUS INJECTION OF METHOTREXATE
25MG/0.5ML (25MG/0.5ML) RASUVO MEDEXUS N205776 July 10, 2014 RX SOLUTION SUBCUTANEOUS 8664231 June 1, 2029 SUBCUTANEOUS INJECTION OF METHOTREXATE
27.5MG/0.55ML (27.5MG/0.55ML) RASUVO MEDEXUS N205776 July 10, 2014 DISCN SOLUTION SUBCUTANEOUS 8664231 June 1, 2029 SUBCUTANEOUS INJECTION OF METHOTREXATE
30MG/0.6ML (30MG/0.6ML) RASUVO MEDEXUS N205776 July 10, 2014 RX SOLUTION SUBCUTANEOUS 8664231 June 1, 2029 SUBCUTANEOUS INJECTION OF METHOTREXATE
7.5MG/0.15ML (7.5MG/0.15ML) RASUVO MEDEXUS N205776 July 10, 2014 RX SOLUTION SUBCUTANEOUS 8664231 June 1, 2029 SUBCUTANEOUS INJECTION OF METHOTREXATE
10MG/0.4ML (10MG/0.4ML) OTREXUP OTTER PHARMS N204824 Oct. 11, 2013 RX SOLUTION SUBCUTANEOUS 8480631 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
10MG/0.4ML (10MG/0.4ML) OTREXUP OTTER PHARMS N204824 Oct. 11, 2013 RX SOLUTION SUBCUTANEOUS 8579865 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
10MG/0.4ML (10MG/0.4ML) OTREXUP OTTER PHARMS N204824 Oct. 11, 2013 RX SOLUTION SUBCUTANEOUS 8945063 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
10MG/0.4ML (10MG/0.4ML) OTREXUP OTTER PHARMS N204824 Oct. 11, 2013 RX SOLUTION SUBCUTANEOUS 9421333 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
12.5MG/0.4ML (12.5MG/0.4ML) OTREXUP OTTER PHARMS N204824 March 24, 2016 RX SOLUTION SUBCUTANEOUS 8480631 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
12.5MG/0.4ML (12.5MG/0.4ML) OTREXUP OTTER PHARMS N204824 March 24, 2016 RX SOLUTION SUBCUTANEOUS 8579865 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
12.5MG/0.4ML (12.5MG/0.4ML) OTREXUP OTTER PHARMS N204824 March 24, 2016 RX SOLUTION SUBCUTANEOUS 8945063 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
12.5MG/0.4ML (12.5MG/0.4ML) OTREXUP OTTER PHARMS N204824 March 24, 2016 RX SOLUTION SUBCUTANEOUS 9421333 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
15MG/0.4ML (15MG/0.4ML) OTREXUP OTTER PHARMS N204824 Oct. 11, 2013 RX SOLUTION SUBCUTANEOUS 8480631 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
15MG/0.4ML (15MG/0.4ML) OTREXUP OTTER PHARMS N204824 Oct. 11, 2013 RX SOLUTION SUBCUTANEOUS 8579865 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
15MG/0.4ML (15MG/0.4ML) OTREXUP OTTER PHARMS N204824 Oct. 11, 2013 RX SOLUTION SUBCUTANEOUS 8945063 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
15MG/0.4ML (15MG/0.4ML) OTREXUP OTTER PHARMS N204824 Oct. 11, 2013 RX SOLUTION SUBCUTANEOUS 9421333 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
17.5MG/0.4ML (17.5MG/0.4ML) OTREXUP OTTER PHARMS N204824 March 24, 2016 RX SOLUTION SUBCUTANEOUS 8480631 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
17.5MG/0.4ML (17.5MG/0.4ML) OTREXUP OTTER PHARMS N204824 March 24, 2016 RX SOLUTION SUBCUTANEOUS 8579865 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
17.5MG/0.4ML (17.5MG/0.4ML) OTREXUP OTTER PHARMS N204824 March 24, 2016 RX SOLUTION SUBCUTANEOUS 8945063 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
17.5MG/0.4ML (17.5MG/0.4ML) OTREXUP OTTER PHARMS N204824 March 24, 2016 RX SOLUTION SUBCUTANEOUS 9421333 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
20MG/0.4ML (20MG/0.4ML) OTREXUP OTTER PHARMS N204824 Oct. 11, 2013 RX SOLUTION SUBCUTANEOUS 8480631 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
20MG/0.4ML (20MG/0.4ML) OTREXUP OTTER PHARMS N204824 Oct. 11, 2013 RX SOLUTION SUBCUTANEOUS 8579865 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
20MG/0.4ML (20MG/0.4ML) OTREXUP OTTER PHARMS N204824 Oct. 11, 2013 RX SOLUTION SUBCUTANEOUS 8945063 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
20MG/0.4ML (20MG/0.4ML) OTREXUP OTTER PHARMS N204824 Oct. 11, 2013 RX SOLUTION SUBCUTANEOUS 9421333 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
22.5MG/0.4ML (22.5MG/0.4ML) OTREXUP OTTER PHARMS N204824 March 24, 2016 RX SOLUTION SUBCUTANEOUS 8480631 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
22.5MG/0.4ML (22.5MG/0.4ML) OTREXUP OTTER PHARMS N204824 March 24, 2016 RX SOLUTION SUBCUTANEOUS 8579865 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
22.5MG/0.4ML (22.5MG/0.4ML) OTREXUP OTTER PHARMS N204824 March 24, 2016 RX SOLUTION SUBCUTANEOUS 8945063 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
22.5MG/0.4ML (22.5MG/0.4ML) OTREXUP OTTER PHARMS N204824 March 24, 2016 RX SOLUTION SUBCUTANEOUS 9421333 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
25MG/0.4ML (25MG/0.4ML) OTREXUP OTTER PHARMS N204824 Oct. 11, 2013 RX SOLUTION SUBCUTANEOUS 8480631 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
25MG/0.4ML (25MG/0.4ML) OTREXUP OTTER PHARMS N204824 Oct. 11, 2013 RX SOLUTION SUBCUTANEOUS 8579865 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
25MG/0.4ML (25MG/0.4ML) OTREXUP OTTER PHARMS N204824 Oct. 11, 2013 RX SOLUTION SUBCUTANEOUS 8945063 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
25MG/0.4ML (25MG/0.4ML) OTREXUP OTTER PHARMS N204824 Oct. 11, 2013 RX SOLUTION SUBCUTANEOUS 9421333 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
7.5MG/0.4ML (7.5MG/0.4ML) OTREXUP OTTER PHARMS N204824 Nov. 7, 2014 DISCN SOLUTION SUBCUTANEOUS 8480631 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
7.5MG/0.4ML (7.5MG/0.4ML) OTREXUP OTTER PHARMS N204824 Nov. 7, 2014 DISCN SOLUTION SUBCUTANEOUS 8579865 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
7.5MG/0.4ML (7.5MG/0.4ML) OTREXUP OTTER PHARMS N204824 Nov. 7, 2014 DISCN SOLUTION SUBCUTANEOUS 8945063 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
7.5MG/0.4ML (7.5MG/0.4ML) OTREXUP OTTER PHARMS N204824 Nov. 7, 2014 DISCN SOLUTION SUBCUTANEOUS 9421333 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
EQ 2.5MG BASE/ML XATMEP AZURITY N208400 April 25, 2017 RX SOLUTION ORAL 10231927 Jan. 2, 2033 A METHOD FOR TREATING ACUTE LYMPHOBLASTIC LEUKEMIA
EQ 2.5MG BASE/ML XATMEP AZURITY N208400 April 25, 2017 RX SOLUTION ORAL 10231927 Jan. 2, 2033 TREATMENT OF JUVENILE RHEUMATOID ARTHRITIS
EQ 2.5MG BASE/ML XATMEP AZURITY N208400 April 25, 2017 RX SOLUTION ORAL 11116724 Jan. 2, 2033 A METHOD FOR TREATING ACUTE LYMPHOBLASTIC LEUKEMIA
EQ 2.5MG BASE/ML XATMEP AZURITY N208400 April 25, 2017 RX SOLUTION ORAL 11116724 Jan. 2, 2033 TREATMENT OF JUVENILE RHEUMATOID ARTHRITIS

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
EQ 2.5MG BASE/ML XATMEP AZURITY N208400 April 25, 2017 RX SOLUTION ORAL April 25, 2024 TREATMENT OF OLIGOARTICULAR JUVENILE IDIOPATHIC ARTHRITIS (PERSISTENT OLIGOARTHRITIS, PSORIATIC JUVENILE IDIOPATHIC ARTHRITIS, ENTHESITIS-RELATED ARTHRITIS, OR UNDIFFERENTIATED ARTHRITIS) & POLYARTICULAR JUVENILE IDIOPATHIC ARTHRITIS IN CHILDREN 0-16 YRS
EQ 2.5MG BASE/ML XATMEP AZURITY N208400 April 25, 2017 RX SOLUTION ORAL April 25, 2024 TREATMENT OF PEDIATRIC PATIENTS WITH ACUTE LYMPHOBLASTIC LEUKEMIA AS A COMPONENT OF A COMBINATION CHEOMOTHERAPY MAINTENANCE REGIMEN

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Dihydrofolate reductase Enzyme INHIBITOR Ki 8.92 IUPHAR DRUG LABEL
Canalicular multispecific organic anion transporter 1 Transporter WOMBAT-PK
Multidrug resistance-associated protein 1 Transporter WOMBAT-PK
ATP-binding cassette sub-family G member 2 Transporter WOMBAT-PK
Thymidylate synthase Enzyme Ki 6.22 CHEMBL
Multidrug resistance-associated protein 5 Transporter WOMBAT-PK
Folylpolyglutamate synthase, mitochondrial Enzyme IC50 5.49 CHEMBL
Multidrug resistance-associated protein 4 Transporter WOMBAT-PK
Folate receptor beta Membrane receptor IC50 6.97 CHEMBL
Proton-coupled folate transporter Transporter IC50 6.92 CHEMBL
Multidrug resistance protein 1 Transporter WOMBAT-PK
Toll-like receptor 4 Membrane receptor IC50 5.98 CHEMBL
Folate transporter 1 Transporter Ki 5.46 CHEMBL
Folate receptor alpha Membrane receptor IC50 6.94 CHEMBL
High mobility group protein B1 Nuclear other Kd 7.62 CHEMBL
Bifunctional purine biosynthesis protein PURH Enzyme Ki 6.06 CHEMBL
Bifunctional dihydrofolate reductase-thymidylate synthase Enzyme IC50 8.85 CHEMBL
Dihydrofolate reductase Enzyme IC50 9 CHEMBL
Bifunctional dihydrofolate reductase-thymidylate synthase Enzyme IC50 7.08 CHEMBL
Dihydrofolate reductase Enzyme Ki 5.41 CHEMBL
Dihydrofolate reductase Enzyme Ki 10.14 CHEMBL
Dihydrofolate reductase Enzyme Ki 10.68 CHEMBL
Dihydrofolate reductase Enzyme IC50 8.89 CHEMBL
Thymidylate synthase Enzyme Ki 4.35 CHEMBL
Dihydrofolate reductase Enzyme IC50 7.72 CHEMBL
Thymidylate synthase Enzyme IC50 4.40 CHEMBL
Dihydrofolate reductase Enzyme Ki 10.68 CHEMBL
Thymidylate synthase Enzyme IC50 5.74 CHEMBL
Pteridine reductase 1 Enzyme Ki 7.41 CHEMBL
Bifunctional dihydrofolate reductase-thymidylate synthase Enzyme IC50 6.96 CHEMBL
Dihydrofolate reductase Enzyme Ki 9 CHEMBL
Dihydrofolate reductase Enzyme IC50 8.08 CHEMBL
Dihydrofolate reductase Enzyme IC50 7.91 CHEMBL
Dihydrofolate reductase Enzyme IC50 8.77 CHEMBL
Dihydrofolate reductase Enzyme IC50 8.85 CHEMBL
Bifunctional dihydrofolate reductase-thymidylate synthase Enzyme Ki 9.89 CHEMBL

External reference:

IDSource
4019828 VUID
N0000147916 NUI
D00142 KEGG_DRUG
7413-34-5 SECONDARY_CAS_RN
4017903 VANDF
4019828 VANDF
C0025677 UMLSCUI
CHEBI:44185 CHEBI
MTX PDB_CHEM_ID
CHEMBL34259 ChEMBL_ID
CHEMBL426 ChEMBL_ID
CHEMBL3244648 ChEMBL_ID
D008727 MESH_DESCRIPTOR_UI
DB00563 DRUGBANK_ID
4815 IUPHAR_LIGAND_ID
926 INN_ID
YL5FZ2Y5U1 UNII
126941 PUBCHEM_CID
287734 RXNORM
12261 MMSL
30391 MMSL
5077 MMSL
6313 MMSL
73119 MMSL
d00060 MMSL
002644 NDDF
002645 NDDF
387381009 SNOMEDCT_US
412247000 SNOMEDCT_US
68887009 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Methotrexate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0054-4550 TABLET 2.50 mg ORAL ANDA 28 sections
Methotrexate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0054-4550 TABLET 2.50 mg ORAL ANDA 28 sections
Methotrexate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0054-8550 TABLET 2.50 mg ORAL ANDA 28 sections
Methotrexate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0054-8550 TABLET 2.50 mg ORAL ANDA 28 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 0143-9367 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 1 g INTRA-ARTERIAL ANDA 23 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 0143-9516 SOLUTION 25 mg INTRA-ARTERIAL ANDA 33 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 0143-9516 SOLUTION 25 mg INTRA-ARTERIAL ANDA 33 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 0143-9517 SOLUTION 25 mg INTRA-ARTERIAL ANDA 33 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 0143-9517 SOLUTION 25 mg INTRA-ARTERIAL ANDA 33 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 0143-9518 SOLUTION 25 mg INTRA-ARTERIAL ANDA 33 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 0143-9518 SOLUTION 25 mg INTRA-ARTERIAL ANDA 33 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 0143-9519 SOLUTION 25 mg INTRA-ARTERIAL ANDA 33 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 0143-9519 SOLUTION 25 mg INTRA-ARTERIAL ANDA 33 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 0143-9830 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 1 g INTRA-ARTERIAL ANDA 23 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 0378-0014 TABLET 2.50 mg ORAL ANDA 28 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 0378-0014 TABLET 2.50 mg ORAL ANDA 28 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 0555-0572 TABLET 2.50 mg ORAL ANDA 28 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 0555-0572 TABLET 2.50 mg ORAL ANDA 28 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 0703-3671 INJECTION, SOLUTION 25 mg INTRA-ARTERIAL ANDA 28 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 0703-3675 INJECTION, SOLUTION 25 mg INTRA-ARTERIAL ANDA 28 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 0703-3678 INJECTION, SOLUTION 25 mg INTRA-ARTERIAL ANDA 28 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 0703-3678 INJECTION, SOLUTION 25 mg INTRA-ARTERIAL ANDA 28 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 0703-3678 INJECTION, SOLUTION 25 mg INTRA-ARTERIAL ANDA 28 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 0904-7141 TABLET 2.50 mg ORAL ANDA 26 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 0904-7141 TABLET 2.50 mg ORAL ANDA 26 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 16729-277 INJECTION 25 mg INTRA-ARTERIAL ANDA 29 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 16729-486 TABLET 2.50 mg ORAL ANDA 30 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 42291-505 TABLET 2.50 mg ORAL ANDA 28 sections
Methotrexate Human Prescription Drug Label 1 47335-235 TABLET 2.50 mg ORAL ANDA 30 sections
METHOTREXATE HUMAN PRESCRIPTION DRUG LABEL 1 47781-482 TABLET 2.50 mg ORAL ANDA 27 sections