methotrexate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
folic acid analogues 1751 59-05-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • methotrexate
  • methotrexate sodium
  • amethopterin
  • amethopterine
  • L-Amethopterin
  • ledertrexate
  • metatrexan
  • methoxtrexate
  • methylaminopterin
An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.
  • Molecular weight: 454.45
  • Formula: C20H22N8O5
  • CLOGP: -0.03
  • LIPINSKI: 1
  • HAC: 13
  • HDO: 5
  • TPSA: 210.54
  • ALOGS: -3.42
  • ROTB: 9
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
2.50 mg O
2.50 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.45 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 81 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 1.10 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 33 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.43 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 2.10 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.37 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 3.90 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Dec. 7, 1953 FDA DAVA PHARMS INC
March 26, 2019 PMDA PFIZER JAPAN INC.

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 13119.83 11.74 38287 871900 880702 54501178
Rheumatoid arthritis 7638.14 11.74 18138 892049 364466 55017414
Drug intolerance 4448.43 11.74 11774 898413 253044 55128836
Treatment failure 3179 11.74 7888 902299 162504 55219376
Joint swelling 2686.10 11.74 10512 899675 279288 55102592
Therapeutic product effect incomplete 2283.17 11.74 5193 904994 100838 55281042
Arthralgia 2230.18 11.74 14790 895397 486879 54895001
Death 2221.51 11.74 1391 908796 340035 55041845
Drug hypersensitivity 2025.05 11.74 9309 900878 265896 55115984
Completed suicide 1982.98 11.74 36 910151 133797 55248083
Therapeutic product effect decreased 1839.59 11.74 6473 903714 162979 55218901
Contraindicated product administered 1833.13 11.74 6892 903295 179394 55202486
Synovitis 1585.69 11.74 5967 904220 155338 55226542
Musculoskeletal stiffness 1281.16 11.74 5457 904730 150550 55231330
Liver function test increased 1229.52 11.74 1870 908317 26263 55355617
Constipation 1130.51 11.74 962 909225 200981 55180899
Lymphoproliferative disorder 1090.40 11.74 654 909533 2374 55379506
Hypotension 1011.17 11.74 1554 908633 248954 55132926
Acute kidney injury 952.20 11.74 1514 908673 239249 55142631
Arthropathy 936.63 11.74 5990 904197 194285 55187595
Alopecia 878.77 11.74 7902 902285 285556 55096324
Dyspnoea 866.83 11.74 5822 904365 586755 54795125
Dehydration 827.43 11.74 808 909379 158017 55223863
Intentional overdose 822.77 11.74 76 910111 68041 55313839
Drug abuse 799.36 11.74 82 910105 67528 55314352
Somnolence 766.02 11.74 908 909279 162505 55219375
Hyponatraemia 750.13 11.74 356 909831 101783 55280097
Psoriatic arthropathy 744.56 11.74 2760 907427 71248 55310632
Pain 705.27 11.74 14812 895375 648372 54733508
Anaemia 701.35 11.74 2113 908074 265398 55116482
Infection 671.35 11.74 5530 904657 194676 55187204
Dizziness 645.51 11.74 3511 906676 372629 55009251
Arthritis 643.98 11.74 3256 906931 96596 55285284
Bradycardia 624.73 11.74 160 910027 67344 55314536
Electrocardiogram QT prolonged 615.75 11.74 78 910109 54510 55327370
C-reactive protein abnormal 615.05 11.74 1637 908550 35172 55346708
C-reactive protein increased 600.52 11.74 2694 907493 75990 55305890
Hepatic enzyme increased 598.26 11.74 4778 905409 166606 55215274
Cardiac arrest 594.72 11.74 327 909860 85987 55295893
Tremor 589.90 11.74 652 909535 120437 55261443
Multiple sclerosis relapse 588.22 11.74 34 910153 44869 55337011
Psoriasis 586.13 11.74 3006 907181 89686 55292194
Abdominal discomfort 570.28 11.74 6920 903267 270354 55111526
Overdose 564.27 11.74 527 909660 105303 55276577
Swelling 558.70 11.74 6131 904056 233640 55148240
Mouth ulceration 551.82 11.74 1373 908814 28267 55353613
Toxicity to various agents 548.88 11.74 1830 908357 222734 55159146
Red blood cell sedimentation rate increased 543.80 11.74 1560 908627 35063 55346817
Hyperkalaemia 540.30 11.74 87 910100 50778 55331102
Diarrhoea 530.62 11.74 7211 902976 631296 54750584
Anxiety 523.93 11.74 1501 908686 191671 55190209
Cardio-respiratory arrest 504.52 11.74 135 910052 55186 55326694
Red blood cell sedimentation rate abnormal 502.17 11.74 1002 909185 17671 55364209
Decreased appetite 492.01 11.74 1852 908335 217379 55164501
Suicide attempt 479.06 11.74 168 910019 57668 55324212
Depressed level of consciousness 474.22 11.74 160 910027 56273 55325607
Agitation 472.41 11.74 158 910029 55878 55326002
Gastrointestinal disorder 465.41 11.74 3270 906917 109432 55272448
Drug interaction 463.52 11.74 1783 908404 207972 55173908
Seizure 463.34 11.74 820 909367 124299 55257581
Inflammation 462.65 11.74 2277 907910 66794 55315086
Condition aggravated 456.23 11.74 7971 902216 336927 55044953
Hallucination 455.72 11.74 116 910071 49033 55332847
Device expulsion 455.69 11.74 7 910180 30442 55351438
Peripheral swelling 450.05 11.74 5783 904404 228943 55152937
Loss of personal independence in daily activities 449.35 11.74 2543 907644 78826 55303054
Hypokalaemia 444.14 11.74 523 909664 93914 55287966
Sedation 439.92 11.74 32 910155 34822 55347058
Asthenia 439.82 11.74 3494 906693 339479 55042401
Joint stiffness 433.34 11.74 1410 908777 34015 55347865
Systemic lupus erythematosus 424.33 11.74 4616 905571 175462 55206418
Pancytopenia 421.68 11.74 2666 907521 86049 55295831
Malignant neoplasm progression 420.59 11.74 343 909844 73244 55308636
Cardiac failure congestive 417.69 11.74 481 909706 87239 55294641
Hypoglycaemia 416.71 11.74 190 909997 55625 55326255
Fall 415.29 11.74 3738 906449 353772 55028108
International normalised ratio increased 414.04 11.74 101 910086 43940 55337940
Exposure during pregnancy 409.29 11.74 1007 909180 135335 55246545
Balance disorder 405.54 11.74 383 909804 76137 55305743
Syncope 402.50 11.74 707 909480 107492 55274388
Oedema peripheral 398.35 11.74 1425 908762 169829 55212051
Injection site pain 396.88 11.74 3244 906943 113874 55268006
Rhabdomyolysis 394.63 11.74 87 910100 40571 55341309
Plasma cell myeloma 383.75 11.74 137 910050 46509 55335371
Rheumatoid nodule 376.66 11.74 778 909409 14079 55367801
Pneumocystis jirovecii pneumonia 372.27 11.74 800 909387 14901 55366979
Lactic acidosis 371.94 11.74 62 910125 35284 55346596
Injection site reaction 371.38 11.74 1776 908411 51471 55330409
Hand deformity 365.51 11.74 3550 906637 130942 55250938
Osteoarthritis 360.72 11.74 2379 907808 77917 55303963
Product dose omission issue 351.71 11.74 1909 908278 202844 55179036
Tachycardia 350.94 11.74 741 909446 105135 55276745
Coma 340.98 11.74 278 909909 59377 55322503
Haemoglobin decreased 334.40 11.74 1083 909104 133054 55248826
Foot deformity 330.81 11.74 991 909196 22834 55359046
Tuberculosis 329.77 11.74 619 909568 10410 55371470
Muscle spasms 328.82 11.74 1129 909058 136242 55245638
Diffuse large B-cell lymphoma 327.36 11.74 481 909706 6535 55375345
Hospitalisation 326.93 11.74 440 909747 74560 55307320
Orthostatic hypotension 322.29 11.74 71 910116 33128 55348752
Platelet count decreased 320.58 11.74 784 909403 105599 55276281
Fluid retention 320.46 11.74 243 909944 53835 55328045
Pemphigus 317.94 11.74 3913 906274 153299 55228581
Blood glucose increased 316.45 11.74 452 909735 74699 55307181
Intentional self-injury 315.25 11.74 23 910164 24969 55356911
Drug withdrawal syndrome 311.78 11.74 29 910158 25828 55356052
Product use issue 311.75 11.74 4475 905712 181566 55200314
Metabolic acidosis 304.65 11.74 136 910051 40318 55341562
Respiratory arrest 302.39 11.74 63 910124 30562 55351318
Serotonin syndrome 300.79 11.74 37 910150 26453 55355427
Cognitive disorder 297.31 11.74 216 909971 48917 55332963
Confusional state 294.33 11.74 2062 908125 206093 55175787
Chest pain 293.08 11.74 1831 908356 187966 55193914
Lower respiratory tract infection 292.42 11.74 2990 907197 111804 55270076
Therapeutic response decreased 291.93 11.74 1650 908537 51108 55330772
Sopor 289.66 11.74 11 910176 20911 55360969
Hyperhidrosis 289.33 11.74 686 909501 93402 55288478
Interstitial lung disease 286.86 11.74 1740 908447 55323 55326557
Gastrointestinal haemorrhage 279.96 11.74 499 909688 75452 55306428
Juvenile idiopathic arthritis 277.81 11.74 364 909823 4409 55377471
Epstein Barr virus positive mucocutaneous ulcer 277.14 11.74 137 910050 297 55381583
Chest discomfort 276.02 11.74 757 909430 98100 55283780
Unresponsive to stimuli 273.48 11.74 86 910101 31639 55350241
Pain in extremity 273.32 11.74 6514 903673 290917 55090963
Neuropathy peripheral 272.52 11.74 808 909379 102085 55279795
Nodule 272.37 11.74 789 909398 17830 55364050
Asthma 269.04 11.74 928 909259 111842 55270038
Rheumatoid factor positive 266.00 11.74 1971 908216 67089 55314791
Acute graft versus host disease 265.99 11.74 333 909854 3842 55378038
Foetal exposure during pregnancy 263.80 11.74 108 910079 33715 55348165
Nasopharyngitis 262.92 11.74 5025 905162 215934 55165946
Mobility decreased 261.05 11.74 2597 907590 96394 55285486
Bone erosion 259.30 11.74 675 909512 14299 55367581
Renal failure 257.78 11.74 918 909269 109582 55272298
Musculoskeletal pain 257.34 11.74 2215 907972 78937 55302943
Vomiting 256.76 11.74 6117 904070 492111 54889769
Product quality issue 256.32 11.74 96 910091 31640 55350240
Hypoxia 256.02 11.74 296 909891 53601 55328279
Pulmonary fibrosis 252.27 11.74 1052 909135 28706 55353174
Epstein-Barr virus associated lymphoproliferative disorder 251.79 11.74 219 909968 1584 55380296
Drug reaction with eosinophilia and systemic symptoms 245.87 11.74 91 910096 30213 55351667
Disease progression 244.50 11.74 875 909312 104298 55277582
Herpes zoster 244.12 11.74 2078 908109 73811 55308069
Vision blurred 243.04 11.74 620 909567 82323 55299557
Finger deformity 241.63 11.74 404 909783 6173 55375707
Basal cell carcinoma 236.46 11.74 920 909267 24301 55357579
Stomatitis 236.00 11.74 2988 907199 117822 55264058
Suicidal ideation 233.61 11.74 357 909830 57385 55324495
Joint range of motion decreased 233.54 11.74 920 909267 24445 55357435
Flushing 232.75 11.74 490 909697 69610 55312270
Cardiac failure 231.89 11.74 625 909562 81468 55300412
Grip strength decreased 231.21 11.74 682 909505 15574 55366306
White blood cell count decreased 230.59 11.74 1149 909038 124841 55257039
Pulmonary arterial hypertension 229.96 11.74 71 910116 26432 55355448
Cerebrovascular accident 229.36 11.74 828 909359 98442 55283438
Premature delivery 228.57 11.74 76 910111 26984 55354896
Blood potassium decreased 227.55 11.74 175 910012 38497 55343383
Leukoencephalopathy 226.35 11.74 304 909883 3778 55378102
Lymphoma 225.37 11.74 512 909675 9916 55371964
Musculoskeletal disorder 223.32 11.74 750 909437 18397 55363483
Pulmonary embolism 221.60 11.74 934 909253 106190 55275690
Dysgeusia 221.22 11.74 201 909986 40714 55341166
Dyspnoea exertional 218.50 11.74 341 909846 54348 55327532
Full blood count decreased 216.64 11.74 55 910132 23294 55358586
Myalgia 216.16 11.74 1250 908937 130775 55251105
Knee arthroplasty 215.75 11.74 1339 908848 42920 55338960
Impaired healing 215.43 11.74 2250 907937 84591 55297289
Glossodynia 215.27 11.74 3563 906624 148895 55232985
Loss of consciousness 213.68 11.74 974 909213 108375 55273505
Disorientation 212.49 11.74 168 910019 36445 55345435
Epstein-Barr virus infection 212.19 11.74 410 909777 7053 55374827
Mental status changes 211.51 11.74 177 910010 37324 55344556
Ankylosing spondylitis 207.37 11.74 481 909706 9449 55372431
Depression 207.01 11.74 1887 908300 178230 55203650
Atrial fibrillation 205.69 11.74 982 909205 107915 55273965
Blood calcium decreased 205.65 11.74 64 910123 23705 55358175
Uveitis 205.46 11.74 513 909674 10582 55371298
Pulmonary tuberculosis 204.70 11.74 304 909883 4172 55377708
Pulmonary hypertension 203.53 11.74 169 910018 35775 55346105
Palpitations 203.10 11.74 874 909313 98798 55283082
Gastrooesophageal reflux disease 198.63 11.74 685 909502 82572 55299308
Abdominal pain 196.81 11.74 2971 907216 255834 55126046
Restlessness 196.10 11.74 92 910095 26494 55355386
Blood pressure decreased 192.50 11.74 417 909770 58633 55323247
Hypomagnesaemia 191.67 11.74 82 910105 24933 55356947
Hypervolaemia 188.41 11.74 96 910091 26362 55355518
Dyskinesia 188.09 11.74 119 910068 28989 55352891
Lethargy 187.72 11.74 340 909847 51101 55330779
Injection site erythema 186.16 11.74 1994 908193 75454 55306426
Mucosal inflammation 182.93 11.74 1253 908934 41557 55340323
Pneumonia aspiration 182.76 11.74 153 910034 32258 55349622
Withdrawal syndrome 182.22 11.74 38 910149 18424 55363456
Injection site bruising 181.90 11.74 1156 909031 37365 55344515
Hypersensitivity 180.86 11.74 5426 904761 250982 55130898
Pulmonary oedema 180.47 11.74 345 909842 50798 55331082
Wheezing 177.14 11.74 620 909567 74406 55307474
Neutrophil count decreased 175.88 11.74 336 909851 49486 55332394
Sinusitis 175.40 11.74 4308 905879 193273 55188607
Palmar-plantar erythrodysaesthesia syndrome 174.73 11.74 61 910126 21004 55360876
Hyperglycaemia 172.52 11.74 219 909968 38062 55343818
Tuberculin test positive 171.61 11.74 240 909947 3107 55378773
Creatinine renal clearance decreased 171.15 11.74 18 910169 14541 55367339
Blood alkaline phosphatase increased 170.17 11.74 228 909959 38717 55343163
Skin ulcer 169.74 11.74 1138 909049 37470 55344410
Fear of injection 168.48 11.74 344 909843 6171 55375709
Abnormal behaviour 167.65 11.74 59 910128 20213 55361667
Device dislocation 167.08 11.74 78 910109 22528 55359352
Aggression 164.09 11.74 75 910112 21931 55359949
Tenosynovitis 163.32 11.74 508 909679 11953 55369927
Chronic graft versus host disease 163.27 11.74 231 909956 3025 55378855
Caesarean section 161.14 11.74 32 910155 16059 55365821
Joint effusion 161.03 11.74 569 909618 14329 55367551
Arthritis bacterial 160.41 11.74 320 909867 5641 55376239
Dysphagia 158.84 11.74 732 909455 81215 55300665
Angiocentric lymphoma 158.81 11.74 110 910077 540 55381340
Anti-cyclic citrullinated peptide antibody positive 157.16 11.74 2352 907835 96248 55285632
Hallucination, visual 156.66 11.74 44 910143 17424 55364456
Dactylitis 156.43 11.74 181 910006 1911 55379969
Disturbance in attention 156.38 11.74 177 910010 32363 55349517
Neuroleptic malignant syndrome 155.66 11.74 7 910180 11471 55370409
Injection site pruritus 153.68 11.74 1183 909004 40748 55341132
Pulmonary toxicity 151.80 11.74 370 909817 7513 55374367
Epistaxis 151.51 11.74 564 909623 66459 55315421
Premature baby 150.29 11.74 61 910126 19144 55362736
Psychotic disorder 149.91 11.74 98 910089 23460 55358420
Deformity 148.48 11.74 433 909754 9822 55372058
Torsade de pointes 147.22 11.74 15 910172 12425 55369455
Poisoning deliberate 146.00 11.74 3 910184 9950 55371930
Urinary retention 144.65 11.74 144 910043 27930 55353950
Respiratory depression 144.58 11.74 16 910171 12419 55369461
Diabetic ketoacidosis 144.36 11.74 62 910125 18809 55363071
Joint destruction 144.07 11.74 278 909909 4777 55377103
Delirium 142.97 11.74 295 909892 42222 55339658
Sinus bradycardia 142.56 11.74 24 910163 13562 55368318
Right ventricular failure 141.88 11.74 44 910143 16335 55365545
Blood creatinine increased 141.75 11.74 740 909447 79451 55302429
Angioedema 141.61 11.74 285 909902 41168 55340712
Blood iron abnormal 141.20 11.74 220 909967 3157 55378723
Myoclonus 140.68 11.74 36 910151 15167 55366713
Deep vein thrombosis 140.22 11.74 703 909484 76274 55305606
Blood urea increased 139.88 11.74 114 910073 24359 55357521
Emotional distress 139.67 11.74 165 910022 29598 55352282
Lung disorder 139.60 11.74 1382 908805 51215 55330665
B-cell lymphoma 139.47 11.74 219 909968 3165 55378715
Wound 138.66 11.74 3077 907110 135727 55246153
Lymphocyte count decreased 136.42 11.74 150 910037 27789 55354091
Thrombocytopenia 135.25 11.74 1478 908709 134746 55247134
Insomnia 134.82 11.74 2235 907952 189625 55192255
Neoplasm progression 133.32 11.74 194 909993 31822 55350058
Blood sodium decreased 132.75 11.74 100 910087 22234 55359646
Urinary tract infection 132.13 11.74 2922 907265 237591 55144289
Disseminated tuberculosis 131.58 11.74 192 909995 2591 55379289
Irritability 130.51 11.74 172 910015 29416 55352464
Melaena 130.46 11.74 159 910028 28131 55353749
Intentional product misuse 130.23 11.74 413 909774 51091 55330789
Ventricular tachycardia 130.13 11.74 55 910132 16846 55365034
Muscle twitching 129.71 11.74 50 910137 16192 55365688
Nightmare 129.16 11.74 55 910132 16771 55365109
Paraesthesia 128.79 11.74 1418 908769 129096 55252784
Ill-defined disorder 128.57 11.74 1683 908504 66860 55315020
Contraindication to medical treatment 127.51 11.74 97 910090 565 55381315
Febrile bone marrow aplasia 127.12 11.74 309 909878 6263 55375617
Extrapyramidal disorder 127.08 11.74 23 910164 12333 55369547
Abortion spontaneous 126.64 11.74 329 909858 43424 55338456
Heart rate increased 125.99 11.74 808 909379 82465 55299415
Schizophrenia 125.98 11.74 12 910175 10487 55371393
Memory impairment 125.84 11.74 850 909337 85707 55296173
Oedema 124.39 11.74 794 909393 81126 55300754
Folliculitis 123.59 11.74 1397 908790 53582 55328298
Histoplasmosis disseminated 123.46 11.74 129 910058 1203 55380677
Acute respiratory failure 122.14 11.74 195 909992 30799 55351081
Breast cancer 121.88 11.74 1267 908920 47566 55334314
Fine motor skill dysfunction 121.72 11.74 241 909946 4224 55377656
Dystonia 121.70 11.74 26 910161 12395 55369485
Bone pain 121.64 11.74 410 909777 49775 55332105
Pustular psoriasis 121.23 11.74 241 909946 4237 55377643
Parkinsonism 119.78 11.74 9 910178 9537 55372343
Mania 119.45 11.74 21 910166 11499 55370381
Malignant melanoma 118.97 11.74 413 909774 10306 55371574
Osteoporosis 118.54 11.74 1326 908861 50726 55331154
Tubulointerstitial nephritis 117.86 11.74 61 910126 16604 55365276
Disability 117.06 11.74 536 909651 15244 55366636
Hepatotoxicity 117.00 11.74 884 909303 30269 55351611
Blood bilirubin increased 116.79 11.74 226 909961 33128 55348752
Acute graft versus host disease in skin 116.71 11.74 196 909991 3006 55378874
Arrhythmia 116.62 11.74 245 909942 34838 55347042
Acute myocardial infarction 116.23 11.74 195 909992 30198 55351682
Cardiac disorder 115.98 11.74 368 909819 45519 55336361
Rash 115.91 11.74 9363 900824 483684 54898196
Blood creatine phosphokinase increased 115.78 11.74 170 910017 27782 55354098
Infusion related reaction 115.65 11.74 4298 905889 204633 55177247
Drug clearance decreased 115.65 11.74 126 910061 1238 55380642
Hypocalcaemia 115.18 11.74 179 910008 28581 55353299
Dry skin 114.78 11.74 384 909803 46725 55335155
Speech disorder 113.90 11.74 275 909912 37218 55344662
Injection site swelling 113.69 11.74 1141 909046 42437 55339443
Chronic kidney disease 113.66 11.74 327 909860 41729 55340151
Circulatory collapse 112.69 11.74 102 910085 20701 55361179
Neutropenia 112.57 11.74 1838 908349 156329 55225551
Presyncope 112.54 11.74 149 910038 25433 55356447
Fibromyalgia 112.41 11.74 1465 908722 58138 55323742
Pulmonary mass 112.40 11.74 639 909548 19831 55362049
Immunosuppression 112.18 11.74 333 909854 7631 55374249
Anhedonia 112.18 11.74 14 910173 9900 55371980
Electrolyte imbalance 112.08 11.74 77 910110 17956 55363924
Abdominal distension 112.00 11.74 764 909423 76862 55305018
Akathisia 111.94 11.74 7 910180 8645 55373235
Obstructive airways disorder 111.18 11.74 71 910116 17211 55364669
Full blood count abnormal 110.52 11.74 160 910027 26302 55355578
Infusion site pain 110.51 11.74 42 910145 13720 55368160
Thrombosis 110.36 11.74 539 909648 58888 55322992
Premature labour 110.21 11.74 28 910159 11854 55370026
Myocardial infarction 110.08 11.74 965 909222 91905 55289975
Poisoning 109.95 11.74 35 910152 12778 55369102
Mycobacterium tuberculosis complex test positive 109.55 11.74 147 910040 1825 55380055
Arthrodesis 109.13 11.74 172 910015 2494 55379386
Polyarthritis 109.05 11.74 350 909837 8378 55373502
Transfusion 109.00 11.74 41 910146 13479 55368401
Muscle injury 108.67 11.74 1313 908874 51187 55330693
Sinus tachycardia 107.94 11.74 122 910065 22322 55359558
Adverse reaction 107.05 11.74 366 909821 9061 55372819
Pericarditis 106.35 11.74 2407 907780 106516 55275364
Upper gastrointestinal haemorrhage 105.75 11.74 73 910114 16981 55364899
Deafness transitory 105.20 11.74 143 910044 1799 55380081
Chills 105.13 11.74 1105 909082 101499 55280381
Impaired work ability 103.70 11.74 489 909698 14083 55367797
Diverticulitis 102.52 11.74 957 909230 34895 55346985
Coronary artery disease 102.42 11.74 215 909972 30581 55351299
Haemophagocytic lymphohistiocytosis 102.09 11.74 364 909823 9208 55372672
Dysarthria 101.49 11.74 315 909872 39235 55342645
Altered state of consciousness 101.36 11.74 134 910053 22887 55358993
Panniculitis 101.35 11.74 370 909817 9472 55372408
Head injury 101.34 11.74 155 910032 24911 55356969
Hypothermia 100.23 11.74 38 910149 12432 55369448
Cardiogenic shock 99.75 11.74 71 910116 16254 55365626
Lupus-like syndrome 99.64 11.74 432 909755 11995 55369885
Muscle rigidity 99.26 11.74 25 910162 10646 55371234
Cholecystitis chronic 98.43 11.74 19 910168 9729 55372151
Haemorrhage 98.22 11.74 523 909664 55874 55326006
Hallucination, auditory 97.97 11.74 32 910155 11492 55370388
Flatulence 97.83 11.74 226 909961 31062 55350818
Status epilepticus 97.69 11.74 62 910125 15079 55366801
Rash maculo-papular 97.66 11.74 200 909987 28707 55353173
Pregnancy 97.44 11.74 246 909941 32787 55349093
Wrong technique in product usage process 97.14 11.74 547 909640 57621 55324259
Blood glucose decreased 97.08 11.74 99 910088 18988 55362892
Chronic obstructive pulmonary disease 96.38 11.74 539 909648 56876 55325004
Oxygen saturation decreased 96.19 11.74 816 909371 78251 55303629
Rheumatoid lung 96.07 11.74 178 910009 2962 55378918
Demyelination 95.11 11.74 269 909918 5993 55375887
Synovial cyst 94.55 11.74 346 909841 8868 55373012
Shoulder arthroplasty 93.59 11.74 194 909993 3519 55378361
Product substitution issue 92.53 11.74 61 910126 14538 55367342
Cerebral haemorrhage 92.40 11.74 203 909984 28403 55353477
Tardive dyskinesia 91.71 11.74 11 910176 8020 55373860
Hip arthroplasty 91.65 11.74 992 909195 37631 55344249
Venoocclusive liver disease 91.05 11.74 213 909974 4208 55377672
Latent tuberculosis 90.99 11.74 153 910034 2349 55379531
Blood magnesium decreased 90.84 11.74 39 910148 11835 55370045
Joint injury 90.25 11.74 717 909470 24937 55356943
Injection site warmth 89.97 11.74 462 909725 13781 55368099
Urinary incontinence 89.87 11.74 217 909970 29368 55352512
Irritable bowel syndrome 89.29 11.74 1580 908607 66878 55315002
Foot operation 89.18 11.74 263 909924 6004 55375876
Rectal haemorrhage 89.16 11.74 356 909831 41111 55340769
Jaundice 88.73 11.74 193 909994 27101 55354779
Swollen tongue 88.54 11.74 227 909960 30097 55351783
Oral herpes 88.48 11.74 654 909533 22236 55359644
Acute hepatic failure 87.77 11.74 83 910104 16495 55365385
Mucosal ulceration 87.63 11.74 90 910097 821 55381059
Feeling abnormal 87.15 11.74 1577 908610 132025 55249855
Complication associated with device 87.11 11.74 72 910115 15278 55366602
Mental disorder 87.01 11.74 155 910032 23449 55358431
Complication of device insertion 86.85 11.74 4 910183 6420 55375460
Respiratory failure 85.91 11.74 1053 909134 94009 55287871
Graft versus host disease 85.70 11.74 273 909914 6508 55375372
Bone marrow failure 85.42 11.74 764 909423 27522 55354358
Infusion site erythema 84.66 11.74 25 910162 9581 55372299
Sensitivity to weather change 84.32 11.74 268 909919 6381 55375499
Paranoia 84.27 11.74 34 910153 10710 55371170
Joint arthroplasty 84.23 11.74 152 910035 2476 55379404
Immobile 84.20 11.74 237 909950 5265 55376615
Delusion 83.96 11.74 38 910149 11177 55370703
Ejection fraction decreased 83.82 11.74 119 910068 19722 55362158
Respiratory distress 83.55 11.74 249 909938 31418 55350462
Pleural effusion 83.38 11.74 931 909256 84549 55297331
Hospice care 83.06 11.74 4 910183 6176 55375704
Haematoma 82.17 11.74 255 909932 31764 55350116
Sleep apnoea syndrome 81.68 11.74 188 909999 25873 55356007
Generalised tonic-clonic seizure 81.53 11.74 205 909982 27361 55354519
Stevens-Johnson syndrome 80.71 11.74 152 910035 22511 55359369
Foetal methotrexate syndrome 80.20 11.74 36 910151 56 55381824
Depressed mood 80.18 11.74 309 909878 36050 55345830
Haematemesis 79.63 11.74 221 909966 28537 55353343
Eosinophilia 79.40 11.74 126 910061 19951 55361929
Dementia 78.51 11.74 97 910090 17061 55364819
Product administration error 78.45 11.74 136 910051 20793 55361087
Elbow deformity 78.38 11.74 107 910080 1352 55380528
Discomfort 78.32 11.74 2916 907271 138845 55243035
Haematocrit decreased 78.04 11.74 318 909869 36511 55345369
Hodgkin's disease 78.04 11.74 80 910107 728 55381152
Atrioventricular block first degree 77.91 11.74 9 910178 6756 55375124
Hypofibrinogenaemia 77.78 11.74 94 910093 1043 55380837
Neuroendocrine carcinoma of the skin 77.31 11.74 66 910121 464 55381416
Gamma-glutamyltransferase increased 76.72 11.74 251 909936 30754 55351126
Treatment noncompliance 76.70 11.74 270 909917 32353 55349527
Hypothyroidism 76.50 11.74 337 909850 37859 55344021
Spinal stenosis 75.97 11.74 436 909751 13578 55368302
Ascites 75.95 11.74 330 909857 37214 55344666
Dysuria 75.87 11.74 249 909938 30480 55351400
Electrocardiogram QRS complex prolonged 75.25 11.74 3 910184 5464 55376416
Limb deformity 75.19 11.74 183 910004 3712 55378168
Leukocytosis 75.07 11.74 171 910016 23620 55358260
Abnormal dreams 74.93 11.74 31 910156 9618 55372262
Atrioventricular block 74.90 11.74 11 910176 6876 55375004
Infusion site swelling 74.76 11.74 18 910169 7903 55373977
Swelling face 74.48 11.74 565 909622 55504 55326376
Pharyngitis 74.14 11.74 534 909653 18004 55363876
Atrial septal defect 74.07 11.74 9 910178 6497 55375383
Hypophosphataemia 74.01 11.74 32 910155 9670 55372210
Epilepsy 73.57 11.74 189 909998 25042 55356838
Mydriasis 73.28 11.74 44 910143 11027 55370853
Enthesopathy 73.04 11.74 291 909896 7772 55374108
Ulcer 72.94 11.74 617 909570 21868 55360012
No adverse event 72.80 11.74 321 909866 36053 55345827
Off label use 72.31 11.74 10151 900036 546029 54835851
Paraesthesia oral 72.29 11.74 76 910111 14373 55367507
Uterine perforation 71.65 11.74 10 910177 6495 55375385
Lip swelling 71.19 11.74 204 909983 26068 55355812
Myelopathy 71.07 11.74 142 910045 2506 55379374
Gestational diabetes 71.05 11.74 21 910166 8043 55373837
Pollakiuria 71.03 11.74 192 909995 25010 55356870
Multiple sclerosis 70.93 11.74 222 909965 27580 55354300
Device difficult to use 70.90 11.74 43 910144 10718 55371162
Red blood cell count decreased 70.38 11.74 328 909859 36289 55345591
Acute generalised exanthematous pustulosis 69.98 11.74 36 910151 9833 55372047
Transplant rejection 69.31 11.74 37 910150 9897 55371983
Moebius II syndrome 68.62 11.74 23 910164 4 55381876
Cyanosis 68.61 11.74 93 910094 15717 55366163
Macular degeneration 68.06 11.74 126 910061 18782 55363098
Hepatic fibrosis 67.59 11.74 159 910028 3153 55378727
Sleep disorder due to general medical condition, insomnia type 67.54 11.74 1030 909157 42308 55339572
Fear 67.46 11.74 85 910102 14823 55367057
Incorrect product administration duration 67.01 11.74 42 910145 10284 55371596
Pallor 66.55 11.74 186 910001 23963 55357917
Histoplasmosis 66.50 11.74 112 910075 1722 55380158
Hypomania 66.44 11.74 3 910184 4899 55376981
Somnambulism 66.24 11.74 4 910183 5088 55376792
Atypical mycobacterial infection 66.01 11.74 79 910108 867 55381013
Joint dislocation 65.79 11.74 459 909728 15314 55366566
Hepatic encephalopathy 65.77 11.74 41 910146 10069 55371811
Cytokine release syndrome 65.53 11.74 48 910139 10827 55371053
Mucocutaneous ulceration 65.40 11.74 38 910149 128 55381752
Hot flush 65.35 11.74 464 909723 46262 55335618
Adverse drug reaction 65.33 11.74 1445 908742 63687 55318193
Epicondylitis 65.25 11.74 117 910070 1896 55379984
Psychomotor hyperactivity 65.03 11.74 39 910148 9781 55372099
Dialysis 65.00 11.74 38 910149 9664 55372216
Liver disorder 64.76 11.74 1043 909144 43327 55338553
Chromaturia 64.65 11.74 92 910095 15233 55366647
Anuria 64.49 11.74 57 910130 11703 55370177
Ventricular extrasystoles 64.18 11.74 49 910138 10821 55371059
Epidermal necrosis 63.77 11.74 79 910108 901 55380979
Retching 63.49 11.74 75 910112 13455 55368425
Visceral leishmaniasis 63.40 11.74 59 910128 471 55381409
Aphthous ulcer 63.25 11.74 371 909816 11648 55370232
Diabetes mellitus inadequate control 62.96 11.74 80 910107 13900 55367980
Mycobacterium marinum infection 62.87 11.74 43 910144 206 55381674
Injury 62.75 11.74 641 909546 59210 55322670
Granuloma skin 62.69 11.74 253 909934 6798 55375082
Tricuspid valve incompetence 62.69 11.74 73 910114 13180 55368700
Pulseless electrical activity 62.42 11.74 18 910169 7006 55374874
Wrist deformity 62.30 11.74 110 910077 1760 55380120
Inflammatory marker increased 61.91 11.74 228 909959 5862 55376018
Haematotoxicity 61.62 11.74 284 909903 8099 55373781
Pre-eclampsia 61.61 11.74 30 910157 8456 55373424
Hepatic steatosis 61.59 11.74 672 909515 25542 55356338
Hepatitis B reactivation 61.51 11.74 127 910060 2297 55379583
Bronchitis chronic 61.24 11.74 172 910015 3816 55378064
COVID-19 60.98 11.74 850 909337 74208 55307672
Inappropriate antidiuretic hormone secretion 60.63 11.74 80 910107 13676 55368204
Hyperthyroidism 60.55 11.74 76 910111 13276 55368604
Blood potassium increased 60.39 11.74 117 910070 17144 55364736
Retinal toxicity 60.19 11.74 85 910102 1111 55380769
Metastases to bone 60.11 11.74 142 910045 19366 55362514
Hereditary angioedema 59.85 11.74 18 910169 6817 55375063
Product complaint 59.80 11.74 61 910126 11699 55370181
Lymph node tuberculosis 59.74 11.74 69 910118 727 55381153
Renal injury 59.27 11.74 35 910152 8852 55373028
Musculoskeletal deformity 59.10 11.74 96 910091 1430 55380450
Therapy non-responder 58.97 11.74 1353 908834 60002 55321878
Acidosis 58.67 11.74 50 910137 10451 55371429
Transient ischaemic attack 58.66 11.74 311 909876 33266 55348614
Hypovolaemia 58.62 11.74 43 910144 9692 55372188
Ageusia 58.45 11.74 69 910118 12382 55369498
Product physical issue 58.41 11.74 4 910183 4578 55377302
Localised infection 58.22 11.74 689 909498 26723 55355157
Salivary hypersecretion 57.47 11.74 21 910166 7029 55374851
Injection site haemorrhage 57.28 11.74 580 909607 21621 55360259
Hyperlipidaemia 57.26 11.74 130 910057 17979 55363901
Tinnitus 57.21 11.74 270 909917 29772 55352108
Device breakage 57.08 11.74 48 910139 10099 55371781
Stillbirth 56.95 11.74 15 910172 6199 55375681
Ventricular fibrillation 56.62 11.74 56 910131 10896 55370984
Device use error 56.45 11.74 10 910177 5446 55376434
Normal newborn 56.41 11.74 25 910162 7445 55374435
Haemorrhage intracranial 56.40 11.74 74 910113 12681 55369199
Scleritis 55.96 11.74 159 910028 3552 55378328
Supraventricular tachycardia 55.86 11.74 80 910107 13211 55368669
Haemoptysis 55.85 11.74 230 909957 26330 55355550
Nervousness 55.71 11.74 260 909927 28755 55353125
Acute lymphocytic leukaemia recurrent 55.55 11.74 118 910069 2179 55379701
Investigation abnormal 55.45 11.74 100 910087 1628 55380252
Transaminases increased 55.43 11.74 710 909477 28060 55353820
Rheumatoid factor negative 55.42 11.74 58 910129 542 55381338
Unevaluable event 55.39 11.74 498 909689 47189 55334691
Tachypnoea 55.38 11.74 103 910084 15327 55366553
Gastrointestinal pain 54.95 11.74 284 909903 8493 55373387
Acute graft versus host disease in intestine 54.93 11.74 99 910088 1611 55380269
Body height below normal 54.91 11.74 109 910078 1914 55379966
Dermatitis atopic 54.90 11.74 33 910154 8266 55373614
Blood loss anaemia 54.88 11.74 33 910154 8264 55373616
Aspartate aminotransferase increased 54.79 11.74 972 909215 81630 55300250
Mood altered 54.55 11.74 82 910105 13273 55368607
Lennox-Gastaut syndrome 54.52 11.74 42 910145 250 55381630
Ankle deformity 54.22 11.74 50 910137 394 55381486
Graft versus host disease in skin 54.21 11.74 129 910058 2578 55379302
Sleep disorder 53.97 11.74 1455 908732 66208 55315672
Sarcoidosis 53.90 11.74 203 909984 5277 55376603
Infusion site pruritus 53.88 11.74 7 910180 4800 55377080
Troponin increased 53.49 11.74 37 910150 8598 55373282
Epstein-Barr virus associated lymphoma 53.42 11.74 53 910134 462 55381418
Anger 53.39 11.74 66 910121 11606 55370274
Genital haemorrhage 53.36 11.74 22 910165 6840 55375040
Vertigo 53.35 11.74 594 909593 53978 55327902
Pneumonia cryptococcal 53.28 11.74 63 910124 682 55381198
Rheumatoid factor increased 53.24 11.74 90 910097 1388 55380492
Muscle tightness 53.09 11.74 58 910129 10778 55371102
SLE arthritis 53.07 11.74 58 910129 572 55381308
Hypersensitivity pneumonitis 53.04 11.74 120 910067 2317 55379563
Hypoaesthesia oral 52.96 11.74 64 910123 11367 55370513
Toxic epidermal necrolysis 52.78 11.74 181 910006 21861 55360019
Dermatomyositis 52.66 11.74 128 910059 2594 55379286
Pregnancy with contraceptive device 52.57 11.74 4 910183 4195 55377685
Nausea 52.49 11.74 11242 898945 752936 54628944
Drug tolerance decreased 52.30 11.74 384 909803 13027 55368853
Temporal lobe epilepsy 52.13 11.74 46 910141 340 55381540
Tonsillitis 51.87 11.74 194 909993 5026 55376854
Bradyphrenia 51.84 11.74 21 910166 6599 55375281
Pneumonitis 51.84 11.74 757 909430 30807 55351073
Face oedema 51.68 11.74 141 910046 18311 55363569
Hepatitis 51.68 11.74 833 909354 34608 55347272
Panic attack 51.65 11.74 164 910023 20283 55361597
Joint noise 51.64 11.74 157 910030 3647 55378233
Hypercapnia 51.31 11.74 10 910177 5086 55376794
Glycosylated haemoglobin increased 51.21 11.74 63 910124 11102 55370778
Thinking abnormal 51.20 11.74 51 910136 9890 55371990
Respiratory acidosis 50.85 11.74 18 910169 6145 55375735
Bradykinesia 50.00 11.74 9 910178 4845 55377035
Renal impairment 49.72 11.74 962 909225 79751 55302129
X-ray abnormal 49.70 11.74 169 910018 4172 55377708
Helicobacter infection 49.50 11.74 1543 908644 71725 55310155
Forced expiratory volume decreased 49.41 11.74 8 910179 4652 55377228
Amyotrophic lateral sclerosis 49.29 11.74 75 910112 1053 55380827
Underdose 49.17 11.74 207 909980 23550 55358330
Pancreatitis acute 48.91 11.74 224 909963 24900 55356980
Cholestasis 48.86 11.74 246 909941 26667 55355213
Migraine 48.86 11.74 1050 909137 85747 55296133
Taste disorder 48.72 11.74 51 910136 9664 55372216
Blood parathyroid hormone decreased 48.51 11.74 265 909922 8099 55373781
Atrioventricular block second degree 48.40 11.74 3 910184 3733 55378147
Spondyloarthropathy 48.32 11.74 64 910123 784 55381096
Wrist surgery 48.08 11.74 63 910124 763 55381117
Encephalopathy 47.85 11.74 354 909833 34971 55346909
Dermatitis allergic 47.71 11.74 388 909799 13590 55368290
Hip fracture 47.59 11.74 249 909938 26724 55355156
Heparin-induced thrombocytopenia 47.56 11.74 6 910181 4208 55377672
Hyperreflexia 47.50 11.74 13 910174 5237 55376643
Neck pain 47.49 11.74 1318 908869 60237 55321643
Liver function test abnormal 47.31 11.74 1018 909169 44653 55337227
Ovarian hyperstimulation syndrome 47.30 11.74 3 910184 3661 55378219
Skin cancer 47.18 11.74 308 909879 10047 55371833
Non-Hodgkin's lymphoma 47.15 11.74 84 910103 1354 55380526
Throat tightness 47.14 11.74 194 909993 22213 55359667
Hypertension 46.75 11.74 3359 906828 240919 55140961
Blister 46.71 11.74 2181 908006 106706 55275174
Vascular device infection 46.68 11.74 16 910171 5574 55376306
Dry mouth 46.66 11.74 743 909444 63462 55318418
Foetal death 46.63 11.74 42 910145 8545 55373335
Rhinitis allergic 46.55 11.74 41 910146 8433 55373447
Hypotonia 46.45 11.74 43 910144 8634 55373246
Sickle cell anaemia with crisis 46.34 11.74 12 910175 5016 55376864
Hepatic cirrhosis 46.29 11.74 537 909650 20726 55361154
Eye swelling 46.28 11.74 183 910004 21193 55360687
Lip ulceration 46.20 11.74 97 910090 1776 55380104
Skin necrosis 45.98 11.74 350 909837 12011 55369869
Erythema multiforme 45.87 11.74 52 910135 9502 55372378
Pleurisy 45.79 11.74 246 909941 7470 55374410
Renal tubular necrosis 45.68 11.74 65 910122 10763 55371117
Low birth weight baby 45.62 11.74 22 910165 6236 55375644
Mental impairment 45.59 11.74 85 910102 12637 55369243
Lower gastrointestinal haemorrhage 45.59 11.74 30 910157 7157 55374723
Lung adenocarcinoma 45.46 11.74 170 910017 4404 55377476
Cholelithiasis 45.45 11.74 413 909774 39051 55342829
Pre-existing condition improved 45.43 11.74 32 910155 7366 55374514
Synovectomy 45.40 11.74 31 910156 148 55381732
Amnesia 45.36 11.74 504 909683 45818 55336062
Neurotoxicity 45.34 11.74 422 909765 15373 55366507
Osteonecrosis of jaw 45.32 11.74 334 909853 33024 55348856
Neutrophil count increased 45.26 11.74 110 910077 14855 55367025
Atrioventricular block complete 45.25 11.74 33 910154 7461 55374419
Skin plaque 44.95 11.74 229 909958 6809 55375071
Prothrombin time prolonged 44.94 11.74 48 910139 9012 55372868
Spinal column injury 44.90 11.74 97 910090 1813 55380067
Ischaemic stroke 44.74 11.74 132 910055 16710 55365170
Personality change 44.67 11.74 19 910168 5798 55376082
Chronic graft versus host disease in skin 44.56 11.74 57 910130 673 55381207
Erythema 44.36 11.74 2064 908123 153875 55228005
Varicella zoster virus infection 44.24 11.74 116 910071 2468 55379412
Non-alcoholic steatohepatitis 44.12 11.74 83 910104 1398 55380482
Intestinal obstruction 44.04 11.74 268 909919 27703 55354177
Shock 43.93 11.74 191 909996 21537 55360343
Catatonia 43.88 11.74 6 910181 3958 55377922
Adenovirus infection 43.80 11.74 138 910049 3270 55378610
End stage renal disease 43.77 11.74 22 910165 6089 55375791
Patent ductus arteriosus 43.69 11.74 6 910181 3945 55377935
Bronchospasm 43.69 11.74 120 910067 15549 55366331
Muscular weakness 43.66 11.74 1320 908867 103132 55278748
Hepatosplenic T-cell lymphoma 43.63 11.74 52 910135 568 55381312
Surgical failure 43.52 11.74 64 910123 870 55381010
Clonus 43.50 11.74 8 910179 4241 55377639
Onychomycosis 43.49 11.74 216 909971 6356 55375524
Product preparation error 43.43 11.74 12 910175 4804 55377076
Blood pressure fluctuation 43.22 11.74 904 909283 39456 55342424
Accidental exposure to product 43.22 11.74 228 909959 24419 55357461
Foetal growth restriction 43.21 11.74 31 910156 7068 55374812
Pruritus 43.16 11.74 4471 905716 312152 55069728
Nasal ulcer 43.14 11.74 97 910090 1865 55380015
Granulomatous pneumonitis 42.94 11.74 21 910166 44 55381836
Acute coronary syndrome 42.85 11.74 57 910130 9711 55372169
Mitral valve incompetence 42.83 11.74 150 910037 18003 55363877
Malignant respiratory tract neoplasm 42.81 11.74 20 910167 36 55381844
Headache 42.80 11.74 8178 902009 550866 54831014
Drug dependence 42.62 11.74 203 909984 22330 55359550
Application site erythema 42.36 11.74 11 910176 4589 55377291
Aspiration 42.35 11.74 56 910131 9565 55372315
Oligohydramnios 42.30 11.74 22 910165 5972 55375908
Transaminases abnormal 42.16 11.74 50 910137 543 55381337
Adactyly 42.16 11.74 19 910168 30 55381850
Faecaloma 42.10 11.74 35 910152 7406 55374474
Exposure to toxic agent 42.09 11.74 5 910182 3673 55378207
Eye disorder 42.09 11.74 511 909676 19941 55361939
Breast cancer metastatic 42.00 11.74 120 910067 15349 55366531
Coagulopathy 41.95 11.74 158 910029 18558 55363322
Blood prolactin increased 41.86 11.74 3 910184 3306 55378574
Blood calcium increased 41.80 11.74 42 910145 8112 55373768
Skin erosion 41.70 11.74 108 910079 2280 55379600
Pneumonia legionella 41.61 11.74 82 910105 1432 55380448
Graft versus host disease in gastrointestinal tract 41.50 11.74 123 910064 2816 55379064
Hypernatraemia 41.50 11.74 28 910159 6592 55375288
Dizziness postural 41.38 11.74 27 910160 6471 55375409
Urine output decreased 41.34 11.74 69 910118 10708 55371172
Thyroid neoplasm 41.10 11.74 145 910042 3648 55378232
Diffuse large B-cell lymphoma stage IV 41.06 11.74 37 910150 282 55381598
Subdural haematoma 41.01 11.74 99 910088 13400 55368480
Vaginal haemorrhage 40.94 11.74 245 909942 25428 55356452
Breast cancer stage I 40.90 11.74 25 910162 6205 55375675
Atrial flutter 40.74 11.74 53 910134 9116 55372764
Posterior reversible encephalopathy syndrome 40.71 11.74 416 909771 15544 55366336
Duodenal ulcer perforation 40.70 11.74 1418 908769 66924 55314956
Hypoaesthesia 40.60 11.74 1871 908316 139620 55242260
Peritonitis bacterial 40.49 11.74 13 910174 4720 55377160
Pericardial effusion 40.41 11.74 265 909922 26910 55354970
Faeces discoloured 40.40 11.74 140 910047 16856 55365024
Bone swelling 40.37 11.74 81 910106 1434 55380446
Maternal drugs affecting foetus 40.14 11.74 16 910171 5077 55376803
Labelled drug-drug interaction medication error 40.13 11.74 79 910108 11507 55370373
Hepatic failure 40.08 11.74 347 909840 33139 55348741
Palmoplantar pustulosis 40.03 11.74 44 910143 437 55381443
Injection site urticaria 40.00 11.74 348 909839 12435 55369445
Injection site rash 39.97 11.74 435 909752 16523 55365357
Infusion site haemorrhage 39.96 11.74 6 910181 3689 55378191
Renal disorder 39.94 11.74 297 909890 29308 55352572
Ventricular septal defect 39.85 11.74 9 910178 4129 55377751
Unintended pregnancy 39.79 11.74 17 910170 5174 55376706
Ileus 39.69 11.74 105 910082 13777 55368103
Electrocardiogram abnormal 39.45 11.74 44 910143 8100 55373780
Glomerular filtration rate decreased 39.40 11.74 88 910099 12241 55369639
Metabolic encephalopathy 39.36 11.74 18 910169 5262 55376618
Increased appetite 39.32 11.74 50 910137 8685 55373195
Induced abortion failed 39.28 11.74 32 910155 209 55381671
Abortion incomplete 39.09 11.74 3 910184 3124 55378756
Tenderness 39.08 11.74 498 909689 19657 55362223
Catheter site erythema 38.90 11.74 9 910178 4061 55377819
Oral mucosal exfoliation 38.86 11.74 82 910105 1507 55380373
Organising pneumonia 38.67 11.74 180 910007 5155 55376725
Osteoporotic fracture 38.64 11.74 130 910057 3191 55378689
Systemic infection 38.53 11.74 4 910183 3265 55378615
Left ventricular dysfunction 38.39 11.74 76 910111 11047 55370833
Hepatitis E 38.37 11.74 74 910113 1271 55380609
Physical disability 38.24 11.74 104 910083 2263 55379617
Cardiomegaly 38.23 11.74 137 910050 16330 55365550
Rheumatic disorder 37.99 11.74 104 910083 2272 55379608
Systemic lupus erythematosus rash 37.87 11.74 92 910095 1864 55380016
Human antichimeric antibody positive 37.46 11.74 80 910107 1483 55380397
Application site pruritus 37.40 11.74 8 910179 3811 55378069
Euglycaemic diabetic ketoacidosis 37.34 11.74 4 910183 3185 55378695
Synovial disorder 37.34 11.74 66 910121 1057 55380823
Oliguria 37.28 11.74 49 910138 8391 55373489
Cutaneous T-cell lymphoma 37.22 11.74 74 910113 1301 55380579
Encephalitis 37.08 11.74 241 909946 7849 55374031
Product residue present 37.06 11.74 8 910179 3787 55378093
Ketoacidosis 37.04 11.74 10 910177 4065 55377815
White blood cell count increased 37.02 11.74 505 909682 44254 55337626
Choking 36.98 11.74 55 910132 8942 55372938
Cataract 36.96 11.74 1088 909099 50159 55331721
Infusion site extravasation 36.95 11.74 47 910140 8163 55373717
Eye irritation 36.83 11.74 170 910017 18858 55363022
Oxygen consumption increased 36.82 11.74 7 910180 3624 55378256
Extranodal marginal zone B-cell lymphoma (MALT type) 36.81 11.74 43 910144 459 55381421
Cold sweat 36.72 11.74 76 910111 10867 55371013
Central nervous system lymphoma 36.66 11.74 79 910108 1474 55380406
Drug screen positive 36.61 11.74 6 910181 3458 55378422
Leukaemia recurrent 36.59 11.74 72 910115 1256 55380624
Myocarditis 36.56 11.74 54 910133 8804 55373076
Pulmonary sarcoidosis 36.56 11.74 60 910127 902 55380978
Incontinence 36.49 11.74 74 910113 10661 55371219
Small intestinal obstruction 36.45 11.74 144 910043 16681 55365199
Urine leukocyte esterase positive 36.43 11.74 4 910183 3124 55378756
Ovarian neoplasm 36.33 11.74 57 910130 823 55381057
Activated partial thromboplastin time prolonged 36.31 11.74 32 910155 6580 55375300
Ear infection 36.18 11.74 709 909478 30586 55351294
Myelitis 36.18 11.74 71 910116 1236 55380644
Restless legs syndrome 36.11 11.74 146 910041 16801 55365079
Peritoneal tuberculosis 36.06 11.74 43 910144 470 55381410
Blood pressure inadequately controlled 36.00 11.74 14 910173 4510 55377370
Complications of bone marrow transplant 35.99 11.74 41 910146 425 55381455
Alveolitis 35.98 11.74 110 910077 2563 55379317
Long QT syndrome 35.66 11.74 4 910183 3072 55378808
Procedural pain 35.41 11.74 139 910048 16132 55365748
Haematuria 35.34 11.74 273 909914 26714 55355166
Screaming 35.33 11.74 4 910183 3050 55378830
Polyuria 35.28 11.74 42 910145 7509 55374371
Synostosis 35.26 11.74 18 910169 43 55381837
Hypoxic-ischaemic encephalopathy 35.26 11.74 10 910177 3935 55377945
Drug specific antibody 35.23 11.74 93 910094 1987 55379893
Aphasia 35.16 11.74 318 909869 30097 55351783
Cutaneous vasculitis 35.11 11.74 162 910025 4622 55377258
Jaundice cholestatic 35.06 11.74 23 910164 5496 55376384
Haemodialysis 34.85 11.74 53 910134 8538 55373342
Feeling hot 34.73 11.74 471 909716 41316 55340564
Blood glucose fluctuation 34.67 11.74 13 910174 4282 55377598
Failure to thrive 34.65 11.74 33 910154 6537 55375343
Proteinuria 34.59 11.74 156 910031 17414 55364466
C-reactive protein decreased 34.58 11.74 55 910132 804 55381076
Hepatic enzyme abnormal 34.52 11.74 170 910017 4985 55376895
Sacroiliitis 34.49 11.74 111 910076 2661 55379219
Mesenteritis 34.38 11.74 30 910157 218 55381662
Seasonal allergy 34.22 11.74 151 910036 16957 55364923
Episcleritis 34.20 11.74 58 910129 897 55380983
Skin lesion 34.09 11.74 642 909545 27493 55354387
Weight decreased 34.02 11.74 3390 906797 237324 55144556
Iritis 33.80 11.74 110 910077 2653 55379227
Pain in jaw 33.73 11.74 450 909737 39586 55342294
Cutaneous leishmaniasis 33.66 11.74 20 910167 71 55381809
Seronegative arthritis 33.53 11.74 109 910078 2627 55379253
Glaucoma 33.53 11.74 428 909759 16901 55364979
Joint space narrowing 33.48 11.74 36 910151 348 55381532
Visual acuity reduced 33.47 11.74 197 909990 20529 55361351
Ear pain 33.44 11.74 693 909494 30197 55351683
Therapy change 33.36 11.74 24 910163 5464 55376416
Psychomotor retardation 33.35 11.74 9 910178 3660 55378220
Adult T-cell lymphoma/leukaemia 33.20 11.74 34 910153 309 55381571
Insurance issue 33.18 11.74 10 910177 3782 55378098
Tonsillar ulcer 33.13 11.74 32 910155 269 55381611
Application site pain 33.12 11.74 11 910176 3909 55377971
Hallucinations, mixed 33.10 11.74 15 910172 4409 55377471
Apnoea 33.07 11.74 41 910146 7201 55374679
Bronchial carcinoma 32.93 11.74 48 910139 647 55381233
Drooling 32.86 11.74 8 910179 3486 55378394
Vascular access complication 32.74 11.74 80 910107 1627 55380253
Hyperventilation 32.66 11.74 26 910161 5622 55376258
Pharyngitis streptococcal 32.61 11.74 264 909923 9234 55372646
Tuberculous pleurisy 32.59 11.74 37 910150 382 55381498
Respiration abnormal 32.58 11.74 26 910161 5615 55376265
Device occlusion 32.36 11.74 35 910152 6534 55375346
Arteriosclerosis 32.27 11.74 65 910122 9388 55372492
Pyrexia 32.19 11.74 6124 904063 412649 54969231
Viral upper respiratory tract infection 32.14 11.74 214 909973 7028 55374852
Haemorrhoids 32.13 11.74 193 909994 20013 55361867
Ulcerative keratitis 32.09 11.74 100 910087 2355 55379525
Aplasia pure red cell 32.06 11.74 15 910172 4327 55377553
Cancer pain 31.94 11.74 5 910182 2981 55378899
Ophthalmic herpes zoster 31.77 11.74 81 910106 1693 55380187
Rales 31.75 11.74 81 910106 10759 55371121
Skin exfoliation 31.73 11.74 413 909774 36487 55345393
Squamous cell carcinoma of lung 31.71 11.74 51 910136 753 55381127
Traumatic lung injury 31.63 11.74 74 910113 1462 55380418
Small for dates baby 31.45 11.74 9 910178 3521 55378359
Tendon rupture 31.40 11.74 220 909967 7350 55374530
Lung transplant 31.38 11.74 5 910182 2942 55378938
Lung neoplasm malignant 31.30 11.74 424 909763 16972 55364908
Granulomatosis with polyangiitis 31.29 11.74 90 910097 2025 55379855
Bundle branch block right 31.23 11.74 19 910168 4728 55377152
Bundle branch block left 31.23 11.74 34 910153 6328 55375552
Skin reaction 31.21 11.74 336 909851 12727 55369153
Epstein-Barr virus antigen positive 31.12 11.74 15 910172 30 55381850
Aspiration bone marrow abnormal 31.12 11.74 15 910172 30 55381850
Embolic stroke 31.04 11.74 10 910177 3623 55378257
Hyperlactacidaemia 30.94 11.74 3 910184 2585 55379295
Cytomegalovirus chorioretinitis 30.90 11.74 78 910109 1620 55380260
Leukopenia 30.86 11.74 1423 908764 69517 55312363
Angina pectoris 30.83 11.74 296 909891 27680 55354200
Ankle arthroplasty 30.79 11.74 71 910116 1389 55380491
Mycobacterium chelonae infection 30.77 11.74 39 910148 456 55381424
Arachnoiditis 30.72 11.74 30 910157 256 55381624
Disability assessment scale score increased 30.69 11.74 106 910081 2638 55379242
Joint laxity 30.65 11.74 98 910089 2341 55379539
Asphyxia 30.62 11.74 29 910158 5760 55376120
Urine abnormality 30.52 11.74 38 910149 6661 55375219
Amylase increased 30.42 11.74 29 910158 5742 55376138
Ventricular arrhythmia 30.42 11.74 9 910178 3445 55378435
Eyelid oedema 30.18 11.74 71 910116 9697 55372183
Extrapulmonary tuberculosis 30.16 11.74 31 910156 283 55381597
Ataxia 30.11 11.74 125 910062 14278 55367602
Skin papilloma 30.03 11.74 148 910039 4341 55377539
Myocardial ischaemia 30.03 11.74 98 910089 12018 55369862
Coma scale abnormal 29.91 11.74 21 910166 4842 55377038
Hypersomnia 29.87 11.74 149 910038 16192 55365688
Clostridium difficile infection 29.87 11.74 288 909899 26910 55354970
Haemorrhagic stroke 29.85 11.74 26 910161 5377 55376503
International normalised ratio abnormal 29.80 11.74 6 910181 2982 55378898
Acute pulmonary histoplasmosis 29.74 11.74 22 910165 122 55381758
Azotaemia 29.73 11.74 15 910172 4143 55377737
Mucosal toxicity 29.70 11.74 33 910154 332 55381548
Product prescribing error 29.68 11.74 236 909951 22950 55358930
Dermatitis psoriasiform 29.49 11.74 81 910106 1773 55380107
Blood pressure systolic abnormal 29.48 11.74 264 909923 9513 55372367
Peripheral coldness 29.46 11.74 86 910101 10925 55370955
Haemolytic anaemia 29.44 11.74 71 910116 9614 55372266
Urticarial vasculitis 29.36 11.74 45 910142 636 55381244
Lacrimation increased 29.31 11.74 175 910012 18173 55363707
Blood phosphorus decreased 29.22 11.74 14 910173 3983 55377897
Multiple drug therapy 29.14 11.74 5 910182 2787 55379093
Breast cancer stage II 29.13 11.74 30 910157 5728 55376152
Eczema 29.12 11.74 276 909911 25877 55356003
Blood lactic acid increased 29.12 11.74 33 910154 6031 55375849
Blood thyroid stimulating hormone increased 29.10 11.74 38 910149 6525 55375355
Hepatitis B 29.07 11.74 126 910061 3498 55378382
Food allergy 29.01 11.74 62 910125 8762 55373118
Gait disturbance 29.00 11.74 3041 907146 160280 55221600
Product use in unapproved indication 28.94 11.74 2649 907538 138173 55243707
Immune thrombocytopenia 28.91 11.74 71 910116 9554 55372326
Hypertonia 28.90 11.74 15 910172 4077 55377803
Metastases to central nervous system 28.82 11.74 100 910087 12036 55369844
Enterovirus test positive 28.81 11.74 22 910165 129 55381751
Post-traumatic stress disorder 28.71 11.74 19 910168 4519 55377361
Rash erythematous 28.65 11.74 426 909761 36795 55345085
Bronchitis 28.55 11.74 2147 908040 110164 55271716
Disturbance in social behaviour 28.53 11.74 7 910180 3034 55378846
Colitis ischaemic 28.49 11.74 76 910111 9944 55371936
Blood bicarbonate decreased 28.48 11.74 5 910182 2741 55379139
Synovial rupture 28.41 11.74 24 910163 166 55381714
Dysphoria 28.37 11.74 22 910165 4820 55377060
Brain natriuretic peptide increased 28.29 11.74 21 910166 4705 55377175
Therapy interrupted 28.29 11.74 271 909916 25354 55356526
Catheterisation cardiac 28.28 11.74 17 910170 4258 55377622
Extra dose administered 28.28 11.74 28 910159 5445 55376435
Angioimmunoblastic T-cell lymphoma stage IV 28.27 11.74 9 910178 0 55381880
Eosinophil count increased 28.24 11.74 72 910115 9565 55372315
Device leakage 28.17 11.74 37 910150 6338 55375542
Feeling jittery 28.11 11.74 100 910087 11946 55369934
Bunion operation 28.10 11.74 61 910126 1144 55380736
Heavy menstrual bleeding 27.83 11.74 151 910036 16058 55365822
Cardiac murmur 27.72 11.74 93 910094 11308 55370572
Blood thyroid stimulating hormone decreased 27.60 11.74 18 910169 4315 55377565
Human rhinovirus test positive 27.57 11.74 23 910164 156 55381724
Rheumatic fever 27.47 11.74 635 909552 28192 55353688
Cerebral infarction 27.47 11.74 232 909955 22273 55359607
Secretion discharge 27.43 11.74 276 909911 10270 55371610
Carpal tunnel syndrome 27.41 11.74 429 909758 17715 55364165
Post procedural haemorrhage 27.38 11.74 49 910138 7400 55374480
Coordination abnormal 27.35 11.74 108 910079 12513 55369367
Antibody test positive 27.27 11.74 94 910093 2337 55379543
Blood chloride decreased 27.26 11.74 27 910160 5250 55376630
Respiratory tract congestion 27.23 11.74 378 909809 15213 55366667
Hypophagia 27.17 11.74 317 909870 28559 55353321
Back pain 27.09 11.74 3389 906798 233781 55148099
Viral vasculitis 27.05 11.74 15 910172 45 55381835
Arthritis infective 27.04 11.74 177 910010 5779 55376101
Toxic skin eruption 27.03 11.74 98 910089 11641 55370239
Haemodynamic instability 26.98 11.74 59 910128 8270 55373610
Mycobacterial infection 26.94 11.74 75 910112 1655 55380225
Tongue neoplasm malignant stage unspecified 26.93 11.74 48 910139 774 55381106
Performance status decreased 26.92 11.74 10 910177 3313 55378567
Hypokinesia 26.84 11.74 111 910076 12692 55369188
Abortion induced 26.79 11.74 74 910113 9571 55372309
Drug ineffective for unapproved indication 26.70 11.74 573 909614 25120 55356760
Sudden death 26.62 11.74 74 910113 9551 55372329
Hyperthermia 26.58 11.74 59 910128 8226 55373654
Epstein-Barr viraemia 26.47 11.74 52 910135 906 55380974
Galactorrhoea 26.46 11.74 15 910172 3880 55378000
Hepatosplenomegaly 26.36 11.74 93 910094 2340 55379540
Pulmonary arterial pressure increased 26.34 11.74 11 910176 3394 55378486
Choriocarcinoma 26.29 11.74 19 910168 101 55381779
Infective tenosynovitis 26.23 11.74 27 910160 247 55381633
Nasal polyps 26.16 11.74 10 910177 3255 55378625
Pulse absent 26.14 11.74 25 910162 4942 55376938
Tooth abscess 26.14 11.74 337 909850 13338 55368542
Mood swings 26.08 11.74 161 910026 16586 55365294
Gastric disorder 25.87 11.74 712 909475 32498 55349382
Spinal pain 25.81 11.74 300 909887 11584 55370296
Catheter site pain 25.80 11.74 19 910168 4274 55377606
Varicella zoster pneumonia 25.77 11.74 13 910174 30 55381850
Colon cancer 25.73 11.74 252 909935 9309 55372571
Exercise tolerance decreased 25.73 11.74 27 910160 5111 55376769
Limb operation 25.65 11.74 121 910066 3485 55378395
Blood albumin decreased 25.64 11.74 123 910064 13505 55368375
Acute lymphocytic leukaemia 25.64 11.74 100 910087 2644 55379236
Feeling cold 25.60 11.74 219 909968 20968 55360912
Intervertebral disc protrusion 25.59 11.74 493 909694 21201 55360679
Abdominal pain lower 25.58 11.74 244 909943 22848 55359032
Obsessive-compulsive disorder 25.57 11.74 14 910173 3692 55378188
Emotional disorder 25.52 11.74 107 910080 12188 55369692
Tendon disorder 25.51 11.74 164 910023 5321 55376559
Coccidioidomycosis 25.45 11.74 50 910137 871 55381009
Lower respiratory tract infection viral 25.45 11.74 47 910140 780 55381100
Joint warmth 25.29 11.74 66 910121 1400 55380480
Alcoholism 25.29 11.74 3 910184 2206 55379674
Blood pressure diastolic abnormal 25.28 11.74 293 909894 11305 55370575
Clostridium difficile colitis 25.27 11.74 188 909999 18550 55363330
Anaphylactic shock 25.26 11.74 227 909960 21513 55360367
Joint lock 25.25 11.74 85 910102 2087 55379793
Tibia fracture 25.21 11.74 146 910041 4562 55377318
Foot fracture 25.18 11.74 494 909693 21315 55360565
Major depression 25.17 11.74 53 910134 7531 55374349
Pneumonia viral 25.14 11.74 200 909987 6958 55374922
Eye pruritus 25.14 11.74 131 910056 14075 55367805
Therapeutic response unexpected 24.94 11.74 167 910020 16877 55365003
Inhibitory drug interaction 24.91 11.74 4 910183 2340 55379540
Varicella 24.87 11.74 75 910112 1734 55380146
Plasma cell myeloma recurrent 24.85 11.74 7 910180 2767 55379113
Neoplasm recurrence 24.84 11.74 92 910095 2372 55379508
Carcinoma in situ of skin 24.65 11.74 24 910163 204 55381676
Thirst 24.61 11.74 94 910093 10996 55370884
Catheter site haemorrhage 24.59 11.74 9 910178 3009 55378871
Squamous cell carcinoma 24.56 11.74 220 909967 7928 55373952
Antinuclear antibody positive 24.50 11.74 192 909995 6649 55375231
Sciatica 24.49 11.74 572 909615 25438 55356442
Isosporiasis 24.42 11.74 13 910174 35 55381845
Cartilage atrophy 24.34 11.74 21 910166 150 55381730
Cerebral toxoplasmosis 24.25 11.74 46 910141 780 55381100
Eye movement disorder 24.17 11.74 25 910162 4764 55377116
Pruritus allergic 24.13 11.74 60 910127 1234 55380646
Diffuse large B-cell lymphoma stage III 24.13 11.74 14 910173 47 55381833
Product label confusion 24.03 11.74 52 910135 973 55380907
Craniosynostosis 24.03 11.74 21 910166 153 55381727
Blood triglycerides increased 24.00 11.74 102 910085 11575 55370305
Wheelchair user 23.94 11.74 161 910026 5305 55376575
Bone tuberculosis 23.94 11.74 23 910164 192 55381688
Hypovolaemic shock 23.93 11.74 31 910156 5342 55376538
Application site rash 23.89 11.74 5 910182 2418 55379462
Biliary dyskinesia 23.85 11.74 6 910181 2557 55379323
Haemolysis 23.83 11.74 41 910146 6287 55375593
Visual impairment 23.80 11.74 969 909218 73233 55308647
Bone density decreased 23.78 11.74 313 909874 12447 55369433
Anaemia megaloblastic 23.78 11.74 30 910157 349 55381531
Malnutrition 23.77 11.74 131 910056 13877 55368003
Laryngeal disorder 23.76 11.74 50 910137 917 55380963
Low turnover osteopathy 23.75 11.74 18 910169 3990 55377890
Hepatitis B virus test positive 23.67 11.74 23 910164 195 55381685
Growth failure 23.62 11.74 28 910159 304 55381576
Ganglioneuroma 23.45 11.74 19 910168 123 55381757
Cardiomyopathy 23.44 11.74 160 910027 16098 55365782
Hepatic function abnormal 23.43 11.74 405 909782 34153 55347727
Rheumatoid factor 23.40 11.74 15 910172 63 55381817
Palindromic rheumatism 23.40 11.74 23 910164 198 55381682
Toe operation 23.39 11.74 41 910146 652 55381228
Intervertebral disc space narrowing 23.38 11.74 49 910138 896 55380984
Multiple-drug resistance 23.35 11.74 18 910169 3956 55377924
Pleuropericarditis 23.28 11.74 24 910163 220 55381660
Urine ketone body present 23.24 11.74 5 910182 2372 55379508
Hypoventilation 23.24 11.74 22 910165 4370 55377510
Bronchiectasis 23.23 11.74 285 909902 11149 55370731
Cardioactive drug level increased 23.22 11.74 3 910184 2066 55379814
Rash macular 23.13 11.74 217 909970 20387 55361493
Stress cardiomyopathy 23.12 11.74 64 910123 8272 55373608
Initial insomnia 23.03 11.74 34 910153 5545 55376335
Mean platelet volume decreased 23.03 11.74 83 910104 2111 55379769
Inflammatory pain 23.02 11.74 45 910142 781 55381099
Abdominal wall haematoma 22.97 11.74 8 910179 2759 55379121
Disease susceptibility 22.95 11.74 22 910165 183 55381697
Purpura 22.88 11.74 88 910099 10274 55371606
Middle lobe syndrome 22.88 11.74 12 910175 31 55381849
Tooth infection 22.87 11.74 370 909817 15382 55366498
Disease recurrence 22.86 11.74 526 909661 23334 55358546
Self-injurious ideation 22.86 11.74 5 910182 2345 55379535
Swollen joint count increased 22.82 11.74 532 909655 23652 55358228
Epstein-Barr virus test positive 22.79 11.74 37 910150 551 55381329
Anaemia macrocytic 22.72 11.74 105 910082 2998 55378882
Tubal rupture 22.67 11.74 9 910178 8 55381872
Ankle operation 22.67 11.74 57 910130 1181 55380699
Diplopia 22.66 11.74 215 909972 20154 55361726
Bicytopenia 22.65 11.74 81 910106 2052 55379828
Snoring 22.64 11.74 15 910172 3566 55378314
Alcohol interaction 22.62 11.74 5 910182 2328 55379552
Red cell distribution width decreased 22.58 11.74 68 910119 1571 55380309
Alcohol use 22.57 11.74 3 910184 2022 55379858
Subdural haemorrhage 22.57 11.74 9 910178 2855 55379025
Electrocardiogram T wave inversion 22.53 11.74 13 910174 3330 55378550
Meningoencephalitis herpetic 22.53 11.74 53 910134 1051 55380829
Refusal of treatment by patient 22.52 11.74 30 910157 5108 55376772
Infected dermal cyst 22.46 11.74 32 910155 422 55381458
Electrocardiogram ST segment elevation 22.36 11.74 16 910171 3653 55378227
Diffuse large B-cell lymphoma stage II 22.35 11.74 14 910173 56 55381824
Lyme disease 22.33 11.74 101 910086 2857 55379023
Bloody discharge 22.31 11.74 63 910124 1402 55380478
Catheter site infection 22.30 11.74 24 910163 4490 55377390
Cryptococcosis 22.21 11.74 51 910136 995 55380885
Central nervous system lesion 22.21 11.74 84 910103 9854 55372026
Sleep disorder due to a general medical condition 22.20 11.74 74 910113 9016 55372864
Tumour marker increased 22.14 11.74 22 910165 4271 55377609
Laboratory test abnormal 22.12 11.74 274 909913 24421 55357459
Myelitis transverse 22.12 11.74 53 910134 1064 55380816
Ocular sarcoidosis 22.12 11.74 13 910174 45 55381835
Hypoacusis 22.05 11.74 235 909952 21533 55360347
Osteophyte fracture 21.99 11.74 7 910180 0 55381880
Crying 21.90 11.74 231 909956 21209 55360671
Hyperuricaemia 21.85 11.74 30 910157 5043 55376837
Anal abscess 21.73 11.74 129 910058 4068 55377812
Injection site inflammation 21.71 11.74 111 910076 3305 55378575
Inadequate analgesia 21.70 11.74 8 910179 2663 55379217
Nystagmus 21.70 11.74 38 910149 5787 55376093
Sexual dysfunction 21.68 11.74 14 910173 3374 55378506
Cutaneous tuberculosis 21.68 11.74 19 910168 139 55381741
Nocturia 21.67 11.74 52 910135 7054 55374826
Incorrect dosage administered 21.63 11.74 71 910116 1720 55380160
Dermatitis contact 21.63 11.74 80 910107 9447 55372433
Pancreatitis 21.56 11.74 559 909628 44521 55337359
Dermatitis acneiform 21.56 11.74 23 910164 4321 55377559
Nodular melanoma 21.51 11.74 13 910174 48 55381832
Cholestatic liver injury 21.49 11.74 5 910182 2247 55379633
Leishmaniasis 21.46 11.74 14 910173 61 55381819
Granuloma 21.33 11.74 157 910030 5330 55376550
Acute pulmonary oedema 21.32 11.74 58 910129 7539 55374341
Petit mal epilepsy 21.29 11.74 16 910171 3562 55378318
Cervix carcinoma stage 0 21.28 11.74 27 910160 316 55381564
Morphoea 21.28 11.74 26 910161 292 55381588
Laryngospasm 21.24 11.74 10 910177 2874 55379006
Diverticular perforation 21.18 11.74 108 910079 3212 55378668
Cardiac failure acute 21.15 11.74 73 910114 8800 55373080
Borrelia infection 21.11 11.74 23 910164 226 55381654
Accidental overdose 21.08 11.74 220 909967 20241 55361639
Lymphoedema 21.02 11.74 93 910094 10437 55371443
Blood sodium increased 20.99 11.74 7 910180 2481 55379399
Tearfulness 20.98 11.74 18 910169 3750 55378130
Nail disorder 20.97 11.74 280 909907 11171 55370709
Logorrhoea 20.95 11.74 6 910181 2346 55379534
Gastritis 20.94 11.74 415 909772 34287 55347593
Chronic recurrent multifocal osteomyelitis 20.93 11.74 13 910174 51 55381829
Sensory disturbance 20.91 11.74 118 910069 12425 55369455
Colorectal cancer 20.84 11.74 15 910172 3414 55378466
Social avoidant behaviour 20.83 11.74 10 910177 2842 55379038
Knee deformity 20.82 11.74 51 910136 1039 55380841
Red blood cell sedimentation rate 20.77 11.74 130 910057 4178 55377702
Incoherent 20.75 11.74 23 910164 4246 55377634
Blood pressure increased 20.70 11.74 2043 908144 143133 55238747
Metastases to liver 20.68 11.74 236 909951 21350 55360530
Exostosis 20.59 11.74 348 909839 14595 55367285
Atelectasis 20.56 11.74 206 909981 19102 55362778
Catheter site discharge 20.52 11.74 3 910184 1882 55379998
Eructation 20.50 11.74 59 910128 7529 55374351
Prosthesis user 20.48 11.74 14 910173 67 55381813
Bipolar disorder 20.43 11.74 59 910128 7521 55374359
Micturition urgency 20.42 11.74 73 910114 8708 55373172
Blood cholesterol increased 20.42 11.74 1399 908788 71180 55310700
Acquired claw toe 20.41 11.74 21 910166 192 55381688
Acute graft versus host disease in liver 20.40 11.74 38 910149 635 55381245
Intertrigo 20.39 11.74 30 910157 408 55381472
Peptic ulcer haemorrhage 20.32 11.74 49 910138 988 55380892
Ammonia increased 20.31 11.74 24 910163 4305 55377575
Appetite disorder 20.31 11.74 48 910139 6545 55375335
Electrocardiogram ST segment depression 20.23 11.74 9 910178 2674 55379206
Blood lactate dehydrogenase increased 20.22 11.74 225 909962 20450 55361430
Pelvic pain 20.13 11.74 111 910076 11756 55370124
Chemotherapeutic drug level above therapeutic 20.12 11.74 12 910175 43 55381837
Overlap syndrome 20.08 11.74 38 910149 643 55381237
Oropharyngeal cancer 20.07 11.74 11 910176 32 55381848
Cardiac pacemaker insertion 20.03 11.74 19 910168 3771 55378109
Mass excision 19.99 11.74 25 910162 288 55381592
Adverse event 19.99 11.74 1091 909096 54285 55327595
Anaplastic large-cell lymphoma 19.97 11.74 17 910170 119 55381761
Therapeutic product effect delayed 19.96 11.74 79 910108 2103 55379777
Cytomegalovirus infection 19.95 11.74 430 909757 18866 55363014
Bradyarrhythmia 19.92 11.74 4 910183 1992 55379888
Chronic sinusitis 19.92 11.74 69 910118 8309 55373571
Implant site pain 19.89 11.74 6 910181 2268 55379612
Growth retardation 19.80 11.74 53 910134 1142 55380738
Cystitis haemorrhagic 19.74 11.74 120 910067 3817 55378063
Rheumatoid vasculitis 19.66 11.74 26 910161 318 55381562
Pulmonary nocardiosis 19.59 11.74 20 910167 181 55381699
Septic arthritis staphylococcal 19.58 11.74 29 910158 397 55381483
Euphoric mood 19.56 11.74 25 910162 4333 55377547
Rheumatoid arthritis-associated interstitial lung disease 19.54 11.74 7 910180 3 55381877
Superior sagittal sinus thrombosis 19.53 11.74 39 910148 688 55381192
Tender joint count increased 19.53 11.74 12 910175 46 55381834
Mycobacterium avium complex infection 19.49 11.74 95 910092 2774 55379106
Polycystic ovaries 19.49 11.74 15 910172 3299 55378581
Mycotic allergy 19.48 11.74 42 910145 784 55381096
Blood pressure diastolic decreased 19.46 11.74 429 909758 18894 55362986
Amenorrhoea 19.41 11.74 77 910110 8909 55372971
Metatarsalgia 19.38 11.74 23 910164 250 55381630
Medical device site joint infection 19.38 11.74 19 910168 163 55381717
Double stranded DNA antibody positive 19.37 11.74 25 910162 298 55381582
Salivary gland cancer 19.29 11.74 19 910168 164 55381716
Abscess sweat gland 19.24 11.74 8 910179 9 55381871
Infection reactivation 19.23 11.74 49 910138 1024 55380856
Angina unstable 19.19 11.74 52 910135 6769 55375111
Malignant peritoneal neoplasm 19.19 11.74 39 910148 697 55381183
Eye pain 19.19 11.74 367 909820 30480 55351400
Flank pain 19.18 11.74 144 910043 14181 55367699
Malignant melanoma in situ 19.18 11.74 43 910144 825 55381055
Cutaneous sarcoidosis 19.17 11.74 27 910160 352 55381528
Language disorder 19.14 11.74 4 910183 1937 55379943
Torus fracture 19.13 11.74 17 910170 127 55381753
Decubitus ulcer 19.11 11.74 87 910100 9688 55372192
Anticipatory anxiety 19.10 11.74 48 910139 994 55380886
Rectal cancer 19.09 11.74 72 910115 1873 55380007
Device physical property issue 19.09 11.74 3 910184 1783 55380097
Duodenal ulcer 19.06 11.74 56 910131 7099 55374781
Coronary arterial stent insertion 19.04 11.74 10 910177 2700 55379180
Road traffic accident 19.03 11.74 327 909860 27600 55354280
Body height decreased 19.02 11.74 80 910107 9105 55372775
Meningitis coccidioides 19.02 11.74 10 910177 26 55381854
Intentional product use issue 18.98 11.74 1866 908321 97867 55284013
Brain oedema 18.94 11.74 131 910056 13140 55368740
Drug level increased 18.93 11.74 229 909958 20496 55361384
Legionella infection 18.92 11.74 29 910158 410 55381470
Vaginal discharge 18.88 11.74 45 910142 6118 55375762
Congestive hepatopathy 18.86 11.74 9 910178 2567 55379313
Oropharyngeal discolouration 18.85 11.74 6 910181 0 55381880
Arthritis viral 18.85 11.74 6 910181 0 55381880
Ectrodactyly 18.85 11.74 6 910181 0 55381880
Thrombosis in device 18.83 11.74 11 910176 2799 55379081
Hydronephrosis 18.83 11.74 81 910106 9161 55372719
Laryngitis fungal 18.82 11.74 17 910170 130 55381750
Sinus arrest 18.81 11.74 3 910184 1764 55380116
Dyspepsia 18.78 11.74 1131 909056 82340 55299540
Gout 18.77 11.74 118 910069 12103 55369777
Subdural abscess 18.76 11.74 10 910177 27 55381853
Hair follicle tumour benign 18.73 11.74 27 910160 360 55381520
Squamous cell carcinoma of the oral cavity 18.72 11.74 24 910163 284 55381596
Bedridden 18.71 11.74 252 909935 10073 55371807
Immunodeficiency 18.66 11.74 366 909821 15791 55366089
Colitis microscopic 18.55 11.74 202 909985 7673 55374207
Infiltration anaesthesia 18.53 11.74 19 910168 173 55381707
Malignant neoplasm of conjunctiva 18.52 11.74 11 910176 39 55381841
Medial tibial stress syndrome 18.52 11.74 15 910172 97 55381783
Alanine aminotransferase increased 18.52 11.74 1284 908903 92378 55289502
Shock haemorrhagic 18.51 11.74 79 910108 8954 55372926
Back injury 18.51 11.74 205 909982 7821 55374059
Skin tightness 18.48 11.74 22 910165 3933 55377947
Oral mucosa erosion 18.44 11.74 49 910138 1051 55380829
Product taste abnormal 18.40 11.74 4 910183 1884 55379996
Generalised oedema 18.38 11.74 148 910039 14353 55367527
Nail psoriasis 18.37 11.74 30 910157 449 55381431
Respiratory disorder 18.36 11.74 697 909490 33260 55348620
Wernicke's encephalopathy 18.36 11.74 9 910178 19 55381861
Mixed liver injury 18.36 11.74 22 910165 3922 55377958
Angioimmunoblastic T-cell lymphoma 18.34 11.74 17 910170 135 55381745
Injection site irritation 18.33 11.74 131 910056 4405 55377475
Hypermobility syndrome 18.33 11.74 40 910147 753 55381127
Electrocardiogram T wave abnormal 18.32 11.74 7 910180 2279 55379601
Pharyngeal ulceration 18.29 11.74 37 910150 659 55381221
Diastolic dysfunction 18.28 11.74 40 910147 5605 55376275
Herpes simplex 18.25 11.74 194 909993 7324 55374556
Blood glucose abnormal 18.24 11.74 58 910129 7170 55374710
Brain injury 18.22 11.74 48 910139 6307 55375573
Extrasystoles 18.15 11.74 31 910156 4768 55377112
Empyema 18.14 11.74 70 910117 1841 55380039
Tongue neoplasm 18.13 11.74 11 910176 41 55381839
Malabsorption 18.12 11.74 21 910166 3800 55378080
Small intestinal haemorrhage 18.10 11.74 5 910182 2002 55379878
Dyspnoea at rest 18.04 11.74 21 910166 3792 55378088
Mononeuritis 18.03 11.74 10 910177 30 55381850
T-cell lymphoma 17.96 11.74 37 910150 668 55381212
Peripheral T-cell lymphoma unspecified 17.95 11.74 22 910165 248 55381632
Rotator cuff syndrome 17.92 11.74 286 909901 11857 55370023
Keratitis 17.88 11.74 95 910092 2872 55379008
Sputum increased 17.88 11.74 6 910181 2118 55379762
Blood pH decreased 17.83 11.74 9 910178 2485 55379395
Premature rupture of membranes 17.82 11.74 31 910156 4734 55377146
Therapeutic response shortened 17.81 11.74 231 909956 9155 55372725
Ocular hyperaemia 17.81 11.74 249 909938 21730 55360150
Paradoxical psoriasis 17.80 11.74 19 910168 182 55381698
Gastrointestinal lymphoma 17.78 11.74 12 910175 56 55381824
Dislocation of vertebra 17.78 11.74 149 910038 5266 55376614
Glioma 17.77 11.74 24 910163 300 55381580
Incorrect dose administered 17.76 11.74 682 909505 51865 55330015
Breast abscess 17.75 11.74 61 910126 1514 55380366
Interferon gamma release assay positive 17.74 11.74 11 910176 43 55381837
Subarachnoid haemorrhage 17.72 11.74 109 910078 11238 55370642
Q fever 17.71 11.74 14 910173 87 55381793
Psychiatric symptom 17.68 11.74 32 910155 4812 55377068
Hyperparathyroidism 17.58 11.74 10 910177 2582 55379298
Cervical dysplasia 17.56 11.74 93 910094 2808 55379072
Gestational trophoblastic tumour 17.56 11.74 11 910176 44 55381836
Protein total decreased 17.54 11.74 38 910149 5344 55376536
Infusion site bruising 17.45 11.74 12 910175 2797 55379083
Gastrointestinal toxicity 17.43 11.74 164 910023 5992 55375888
Lung cancer metastatic 17.43 11.74 82 910105 2359 55379521
Injection site haematoma 17.43 11.74 166 910021 6086 55375794
Haematochezia 17.40 11.74 556 909631 43162 55338718
Epstein-Barr virus infection reactivation 17.39 11.74 35 910152 621 55381259
Portal tract inflammation 17.36 11.74 10 910177 33 55381847
Maternal exposure during breast feeding 17.34 11.74 20 910167 3627 55378253
Device use issue 17.27 11.74 7 910180 2199 55379681
Hepatitis cholestatic 17.23 11.74 50 910137 6364 55375516
Blood pressure diastolic increased 17.22 11.74 213 909974 8348 55373532
Lichen myxoedematosus 17.22 11.74 9 910178 23 55381857
Musculoskeletal chest pain 17.19 11.74 219 909968 19422 55362458
Angle closure glaucoma 17.17 11.74 6 910181 2065 55379815
Application site irritation 17.15 11.74 3 910184 1649 55380231
Infusion site infection 17.15 11.74 3 910184 1649 55380231
Oesophagitis 17.12 11.74 145 910042 13912 55367968
Expired product administered 17.08 11.74 41 910146 5561 55376319
Perineal infection 17.07 11.74 16 910171 129 55381751
Post procedural infection 17.07 11.74 208 909979 8124 55373756
Communication disorder 17.06 11.74 8 910179 2305 55379575
Exposure to communicable disease 17.01 11.74 32 910155 539 55381341
Limb fracture 16.96 11.74 9 910178 24 55381856
Disseminated sporotrichosis 16.96 11.74 9 910178 24 55381856
Walking aid user 16.96 11.74 210 909977 8233 55373647
Osteochondrosis 16.92 11.74 49 910138 1107 55380773
Vasculitis 16.88 11.74 337 909850 14586 55367294
Mucormycosis 16.84 11.74 89 910098 2685 55379195
Rib fracture 16.84 11.74 229 909958 20080 55361800
Steroid dependence 16.81 11.74 29 910158 455 55381425
Dysphonia 16.81 11.74 533 909654 41414 55340466
Tongue oedema 16.80 11.74 24 910163 3968 55377912
Economic problem 16.79 11.74 5 910182 1906 55379974
Arteriosclerosis coronary artery 16.78 11.74 67 910120 7738 55374142
Quadriplegia 16.78 11.74 64 910123 1674 55380206
Osteomyelitis 16.77 11.74 514 909673 23832 55358048
Transplant dysfunction 16.75 11.74 32 910155 4714 55377166
Large granular lymphocytosis 16.74 11.74 18 910169 174 55381706
Oropharyngeal pain 16.73 11.74 1573 908614 82215 55299665
Chest X-ray abnormal 16.72 11.74 118 910069 3952 55377928
Nephrogenic anaemia 16.70 11.74 5 910182 1899 55379981
Pyomyositis 16.68 11.74 25 910162 346 55381534
Exposed bone in jaw 16.61 11.74 13 910174 2835 55379045
Hypergammaglobulinaemia benign monoclonal 16.60 11.74 37 910150 707 55381173
Squamous cell carcinoma of the cervix 16.58 11.74 22 910165 270 55381610
JC virus infection 16.58 11.74 68 910119 1841 55380039
Hiatus hernia 16.51 11.74 221 909966 19431 55362449
Gallbladder necrosis 16.46 11.74 6 910181 3 55381877
Vitamin D deficiency 16.46 11.74 122 910065 12048 55369832
Blood urine present 16.43 11.74 140 910047 13415 55368465
Decreased interest 16.42 11.74 15 910172 3031 55378849
Left ventricular hypertrophy 16.40 11.74 35 910152 4949 55376931
Neck mass 16.36 11.74 103 910084 3317 55378563
Cyst 16.32 11.74 294 909893 12484 55369396
Self-medication 16.30 11.74 10 910177 2477 55379403
Pemphigoid 16.29 11.74 50 910137 6250 55375630
Carbohydrate antigen 125 increased 16.26 11.74 11 910176 2586 55379294
Necrotising retinitis 16.26 11.74 26 910161 382 55381498
Diabetic retinopathy 16.25 11.74 8 910179 2241 55379639
Multiple fractures 16.25 11.74 186 910001 7155 55374725
Hypoglycaemic coma 16.25 11.74 9 910178 2358 55379522
General physical health deterioration 16.24 11.74 2456 907731 167554 55214326
Brachiocephalic artery stenosis 16.23 11.74 9 910178 27 55381853
Chondropathy 16.22 11.74 75 910112 2142 55379738
Meningitis tuberculous 16.21 11.74 31 910156 529 55381351
Electroencephalogram abnormal 16.20 11.74 20 910167 3519 55378361
West Nile viral infection 16.18 11.74 25 910162 356 55381524
Supraventricular extrasystoles 16.16 11.74 26 910161 4094 55377786
Myelodysplastic syndrome 16.13 11.74 363 909824 16043 55365837
Ovarian cancer 16.10 11.74 163 910024 6075 55375805
Keratopathy 16.09 11.74 31 910156 532 55381348
Genital abscess 16.09 11.74 20 910167 229 55381651
Pharyngeal abscess 16.05 11.74 21 910166 254 55381626
Anxiety disorder 16.05 11.74 23 910164 3797 55378083
Ocular lymphoma 16.04 11.74 11 910176 53 55381827
Apathy 16.03 11.74 70 910117 7884 55373996
Pneumocystis jirovecii infection 16.03 11.74 53 910134 1289 55380591
Malignant neoplasm of ampulla of Vater 16.00 11.74 9 910178 28 55381852
Papulopustular rosacea 15.99 11.74 8 910179 18 55381862
Tonsil cancer 15.98 11.74 19 910168 207 55381673
Pyoderma gangrenosum 15.97 11.74 99 910088 3171 55378709
Device related infection 15.96 11.74 253 909934 21627 55360253
Respiratory rate increased 15.92 11.74 124 910063 12113 55369767
Mucosal disorder 15.91 11.74 70 910117 1956 55379924
Fear-related avoidance of activities 15.91 11.74 15 910172 122 55381758
Abscess 15.89 11.74 337 909850 14744 55367136
Pleural fibrosis 15.83 11.74 103 910084 3356 55378524
Heart rate irregular 15.80 11.74 237 909950 20442 55361438
Neoplasm malignant 15.76 11.74 560 909627 26495 55355385
Ocular toxicity 15.76 11.74 34 910153 635 55381245
International normalised ratio fluctuation 15.73 11.74 79 910108 2335 55379545
Cough 15.71 11.74 3846 906341 256115 55125765
Angioimmunoblastic T-cell lymphoma stage III 15.70 11.74 5 910182 0 55381880
Respiratory tract ulceration 15.70 11.74 5 910182 0 55381880
Throat irritation 15.70 11.74 405 909782 32278 55349602
Concomitant disease progression 15.67 11.74 7 910180 2075 55379805
Diabetic metabolic decompensation 15.67 11.74 3 910184 1545 55380335
Productive cough 15.63 11.74 746 909441 55486 55326394
Attention deficit hyperactivity disorder 15.62 11.74 12 910175 2642 55379238
Body temperature increased 15.57 11.74 690 909497 33552 55348328
Lung squamous cell carcinoma stage I 15.55 11.74 7 910180 11 55381869
Bone density abnormal 15.50 11.74 98 910089 3161 55378719
Eczema herpeticum 15.45 11.74 15 910172 127 55381753
Leukodystrophy 15.43 11.74 8 910179 20 55381860
Breath sounds abnormal 15.41 11.74 84 910103 8923 55372957
Respiratory rate decreased 15.39 11.74 18 910169 3244 55378636
Follicle centre lymphoma, follicular grade I, II, III 15.38 11.74 12 910175 73 55381807
Guttate psoriasis 15.36 11.74 25 910162 373 55381507
Product monitoring error 15.36 11.74 20 910167 3439 55378441
Haemoperitoneum 15.34 11.74 12 910175 2618 55379262
Libido decreased 15.34 11.74 10 910177 2398 55379482
Poor venous access 15.32 11.74 282 909905 12024 55369856
Erythema induratum 15.30 11.74 17 910170 171 55381709
Lymphoplasmacytoid lymphoma/immunocytoma 15.29 11.74 6 910181 5 55381875
Central venous catheterisation 15.19 11.74 11 910176 2496 55379384
Middle insomnia 15.18 11.74 109 910078 10841 55371039
Pseudomonas test positive 15.18 11.74 34 910153 652 55381228
Polymyositis 15.14 11.74 63 910124 1717 55380163
Polydipsia 15.11 11.74 18 910169 3217 55378663
Anovulatory cycle 15.09 11.74 16 910171 152 55381728
Abscess bacterial 15.08 11.74 18 910169 197 55381683
International normalised ratio decreased 15.07 11.74 28 910159 4168 55377712
Oral disorder 15.01 11.74 200 909987 7975 55373905
Coronary artery occlusion 14.99 11.74 69 910118 7660 55374220
Cerebral haematoma 14.98 11.74 19 910168 3304 55378576
Abdominal pain upper 14.95 11.74 2595 907592 175718 55206162
Perineal necrosis 14.93 11.74 14 910173 113 55381767
Subclavian artery occlusion 14.91 11.74 8 910179 22 55381858
Decreased immune responsiveness 14.91 11.74 122 910065 4281 55377599
Ecchymosis 14.89 11.74 102 910085 10254 55371626
Pulmonary thrombosis 14.85 11.74 73 910114 7964 55373916
Medication error 14.85 11.74 547 909640 41788 55340092
Blood parathyroid hormone increased 14.85 11.74 15 910172 2890 55378990
Rash morbilliform 14.84 11.74 16 910171 2991 55378889
Secondary immunodeficiency 14.84 11.74 49 910138 1191 55380689
Pertussis 14.83 11.74 33 910154 630 55381250
Idiopathic pneumonia syndrome 14.81 11.74 23 910164 329 55381551
Enzyme level increased 14.81 11.74 22 910165 302 55381578
Iris adhesions 14.81 11.74 22 910165 302 55381578
Gastrointestinal inflammation 14.79 11.74 134 910053 4844 55377036
Scleroderma renal crisis 14.79 11.74 21 910166 276 55381604
Metastases to reproductive organ 14.78 11.74 6 910181 6 55381874
Poor quality product administered 14.78 11.74 15 910172 2884 55378996
Tendon graft 14.78 11.74 6 910181 6 55381874
Reactive gastropathy 14.77 11.74 25 910162 386 55381494
Hair colour changes 14.74 11.74 15 910172 2880 55379000
Erythrodermic psoriasis 14.73 11.74 42 910145 940 55380940
Nodal osteoarthritis 14.73 11.74 37 910150 766 55381114
Cardiac failure chronic 14.73 11.74 27 910160 4040 55377840
Folate deficiency 14.73 11.74 72 910115 2105 55379775
Pulmonary function test decreased 14.71 11.74 22 910165 3569 55378311
Obliterative bronchiolitis 14.71 11.74 67 910120 1901 55379979
Iridocyclitis 14.61 11.74 74 910113 2195 55379685
Blood chloride increased 14.56 11.74 12 910175 2550 55379330
Plasmablastic lymphoma 14.52 11.74 21 910166 281 55381599
Medical device discomfort 14.48 11.74 5 910182 1734 55380146
Myeloid leukaemia 14.45 11.74 22 910165 309 55381571
Internal haemorrhage 14.42 11.74 35 910152 4729 55377151
Incorrect drug administration rate 14.42 11.74 18 910169 3152 55378728
Menstruation irregular 14.33 11.74 54 910133 6342 55375538
Histiocytic sarcoma 14.32 11.74 12 910175 82 55381798
Bile duct cancer 14.31 11.74 32 910155 613 55381267
Infusion site rash 14.29 11.74 4 910183 1588 55380292
Product prescribing issue 14.26 11.74 6 910181 1843 55380037
Polyarteritis nodosa 14.25 11.74 21 910166 286 55381594
Device loosening 14.24 11.74 25 910162 398 55381482
Invasive ductal breast carcinoma 14.24 11.74 171 910016 6655 55375225
Stress at work 14.24 11.74 46 910141 1105 55380775
Localised oedema 14.24 11.74 38 910149 4971 55376909
Photopsia 14.19 11.74 28 910159 4075 55377805
Ileal stenosis 14.19 11.74 56 910131 1489 55380391
N-terminal prohormone brain natriuretic peptide increased 14.17 11.74 6 910181 1836 55380044
Faecal calprotectin increased 14.16 11.74 83 910104 2605 55379275
Skin discolouration 14.14 11.74 435 909752 33921 55347959
Blood creatine increased 14.14 11.74 40 910147 5133 55376747
Bone disorder 14.11 11.74 415 909772 19128 55362752
Ventricular hypertrophy 14.10 11.74 19 910168 3219 55378661
Nasal congestion 14.09 11.74 756 909431 55614 55326266
Homicidal ideation 14.07 11.74 5 910182 1703 55380177
Lower respiratory tract inflammation 14.04 11.74 13 910174 103 55381777
Gastrointestinal sounds abnormal 14.01 11.74 25 910162 3780 55378100
Drug eruption 13.98 11.74 529 909658 25234 55356646
Quadrantanopia 13.97 11.74 8 910179 26 55381854
Axial spondyloarthritis 13.97 11.74 20 910167 265 55381615
Extremity contracture 13.95 11.74 49 910138 1230 55380650
Vasculitic rash 13.93 11.74 49 910138 1231 55380649
Femoroacetabular impingement 13.92 11.74 7 910180 16 55381864
Multiple organ dysfunction syndrome 13.90 11.74 704 909483 52066 55329814
Corneal oedema 13.88 11.74 3 910184 1419 55380461
Non-cardiac chest pain 13.88 11.74 49 910138 5867 55376013
Device alarm issue 13.87 11.74 3 910184 1418 55380462
Eye infection toxoplasmal 13.86 11.74 20 910167 267 55381613
Abscess limb 13.84 11.74 122 910065 4376 55377504
Bipolar I disorder 13.83 11.74 5 910182 1685 55380195
Eczema infected 13.83 11.74 9 910178 39 55381841
Vitreous floaters 13.82 11.74 45 910142 5522 55376358
Discouragement 13.80 11.74 42 910145 976 55380904
Candida pneumonia 13.77 11.74 14 910173 126 55381754
Oesophageal squamous cell carcinoma 13.77 11.74 14 910173 126 55381754
Orthopnoea 13.76 11.74 48 910139 5768 55376112
Body temperature decreased 13.76 11.74 387 909800 17721 55364159
Temperature intolerance 13.75 11.74 75 910112 7965 55373915
Device failure 13.71 11.74 46 910141 5593 55376287
Foreign body sensation in eyes 13.71 11.74 7 910180 1920 55379960
Listeriosis 13.68 11.74 52 910135 1358 55380522
Acute interstitial pneumonitis 13.65 11.74 32 910155 633 55381247
Metabolic disorder 13.65 11.74 44 910143 5417 55376463
Bursitis infective 13.65 11.74 50 910137 1282 55380598
Herpes simplex meningoencephalitis 13.64 11.74 7 910180 17 55381863
Root canal infection 13.62 11.74 22 910165 326 55381554
Blood pressure abnormal 13.62 11.74 148 910039 13512 55368368
Chronic graft versus host disease oral 13.61 11.74 14 910173 128 55381752
Stenosis 13.61 11.74 50 910137 1284 55380596
Hip surgery 13.60 11.74 87 910100 2818 55379062
Device infusion issue 13.60 11.74 5 910182 1667 55380213
Chronic graft versus host disease in liver 13.59 11.74 20 910167 272 55381608
Lip oedema 13.59 11.74 22 910165 3456 55378424
Sluggishness 13.58 11.74 35 910152 4633 55377247
Spinal meningioma benign 13.58 11.74 13 910174 108 55381772
Soft tissue swelling 13.57 11.74 43 910144 1022 55380858
Right ventricular dysfunction 13.56 11.74 5 910182 1664 55380216
Tongue ulceration 13.55 11.74 93 910094 3086 55378794
Akinesia 13.53 11.74 4 910183 1532 55380348
Injection site discolouration 13.50 11.74 178 910009 7081 55374799
Tubular breast carcinoma 13.50 11.74 9 910178 41 55381839
Plasmacytoma 13.46 11.74 12 910175 2454 55379426
Compartment syndrome 13.46 11.74 8 910179 2016 55379864
Torticollis 13.41 11.74 6 910181 1777 55380103
Ventricular hypokinesia 13.41 11.74 30 910157 4171 55377709
Neutrophil count abnormal 13.41 11.74 14 910173 2656 55379224
Cardiovascular disorder 13.40 11.74 112 910075 10777 55371103
Decreased activity 13.36 11.74 46 910141 5550 55376330
Metastatic bronchial carcinoma 13.36 11.74 14 910173 131 55381749
Bruxism 13.36 11.74 19 910168 3147 55378733
Catheter site swelling 13.34 11.74 3 910184 1380 55380500
Post procedural inflammation 13.34 11.74 9 910178 42 55381838
Granulomatous dermatitis 13.31 11.74 13 910174 111 55381769
Psychogenic seizure 13.29 11.74 5 910182 1644 55380236
Red blood cell sedimentation rate decreased 13.28 11.74 15 910172 154 55381726
Lip and/or oral cavity cancer 13.27 11.74 32 910155 645 55381235
BK virus infection 13.27 11.74 90 910097 2974 55378906
Conduction disorder 13.27 11.74 3 910184 1375 55380505
Immunosuppressant drug level increased 13.26 11.74 20 910167 3233 55378647
DNA antibody positive 13.20 11.74 21 910166 307 55381573
Inability to afford medication 13.18 11.74 6 910181 1759 55380121
Thrombotic thrombocytopenic purpura 13.17 11.74 25 910162 3692 55378188
Perirectal abscess 13.16 11.74 38 910149 857 55381023
Chromosomal deletion 13.15 11.74 8 910179 30 55381850
Injection site induration 13.13 11.74 204 909983 8411 55373469
Laryngitis viral 13.11 11.74 7 910180 19 55381861
Waldenstrom's macroglobulinaemia 13.11 11.74 7 910180 19 55381861
Cytomegalovirus enteritis 13.10 11.74 18 910169 229 55381651
Herpes zoster oticus 13.09 11.74 19 910168 255 55381625
Sinus node dysfunction 13.09 11.74 33 910154 4401 55377479
Application site vesicles 13.08 11.74 3 910184 1362 55380518
Infusion site warmth 13.05 11.74 4 910183 1496 55380384
Discontinued product administered 13.02 11.74 9 910178 44 55381836
Feeling drunk 13.01 11.74 26 910161 3766 55378114
Ototoxicity 13.00 11.74 45 910142 1121 55380759
Device malfunction 13.00 11.74 183 910004 15953 55365927
Lipodystrophy acquired 12.97 11.74 3 910184 1354 55380526
Tender joint count 12.97 11.74 12 910175 95 55381785
Liver injury 12.91 11.74 813 909374 41035 55340845
Periprosthetic fracture 12.90 11.74 25 910162 431 55381449
Thyroid cancer 12.88 11.74 133 910054 4983 55376897
Head discomfort 12.86 11.74 128 910059 11886 55369994
Neck deformity 12.85 11.74 66 910121 1969 55379911
Vagus nerve paralysis 12.83 11.74 5 910182 4 55381876
Genital herpes zoster 12.83 11.74 5 910182 4 55381876
Device related thrombosis 12.82 11.74 5 910182 1608 55380272
Cholesteatoma 12.82 11.74 14 910173 138 55381742
Blepharospasm 12.81 11.74 22 910165 3376 55378504
Fasciitis 12.80 11.74 28 910159 528 55381352
Bronchiolitis obliterans syndrome 12.79 11.74 13 910174 117 55381763
Gestational hypertension 12.78 11.74 11 910176 2288 55379592
Lymphadenopathy 12.77 11.74 694 909493 34514 55347366
Immune effector cell-associated neurotoxicity syndrome 12.76 11.74 5 910182 1603 55380277
Genital cyst 12.72 11.74 9 910178 46 55381834
Drug-device interaction 12.71 11.74 11 910176 79 55381801
Protein urine present 12.67 11.74 48 910139 5628 55376252
Diabetic eye disease 12.67 11.74 14 910173 140 55381740
Vaginal cancer 12.65 11.74 18 910169 237 55381643
Fracture 12.57 11.74 381 909806 17637 55364243
Chronic villitis of unknown etiology 12.56 11.74 4 910183 0 55381880
Bladder papilloma 12.56 11.74 4 910183 0 55381880
CSF myelin basic protein increased 12.56 11.74 4 910183 0 55381880
Hepatic steato-fibrosis 12.56 11.74 4 910183 0 55381880
Leptotrichia infection 12.56 11.74 4 910183 0 55381880
Bursa injury 12.56 11.74 4 910183 0 55381880
Loose body in joint 12.56 11.74 47 910140 1218 55380662
Genital infection 12.55 11.74 10 910177 63 55381817
Joint ankylosis 12.54 11.74 38 910149 881 55380999
Hyperkeratosis 12.53 11.74 137 910050 5210 55376670
Infective exacerbation of bronchiectasis 12.51 11.74 21 910166 322 55381558
Conjunctivitis bacterial 12.50 11.74 20 910167 294 55381586
Iron deficiency anaemia 12.47 11.74 209 909978 17710 55364170
Product name confusion 12.43 11.74 10 910177 64 55381816
Engraftment syndrome 12.41 11.74 24 910163 413 55381467
Placental disorder 12.41 11.74 4 910183 1449 55380431
Pulmonary granuloma 12.41 11.74 48 910139 1264 55380616
Anal incontinence 12.36 11.74 133 910054 12165 55369715
Bone cyst 12.34 11.74 67 910120 2043 55379837
Gelatinous transformation of the bone marrow 12.32 11.74 5 910182 5 55381875
Eosinophil count decreased 12.31 11.74 7 910180 1808 55380072
Essential hypertension 12.31 11.74 37 910150 4656 55377224
Low density lipoprotein increased 12.27 11.74 51 910136 5823 55376057
Gastric neoplasm 12.26 11.74 20 910167 299 55381581
Deafness neurosensory 12.24 11.74 123 910064 4575 55377305
Combined immunodeficiency 12.24 11.74 12 910175 103 55381777
Bowen's disease 12.22 11.74 17 910170 219 55381661
Ischaemic cardiomyopathy 12.21 11.74 12 910175 2342 55379538
T-cell type acute leukaemia 12.19 11.74 10 910177 66 55381814
Injection site hypersensitivity 12.18 11.74 62 910125 1843 55380037
Diffuse alveolar damage 12.15 11.74 36 910151 824 55381056
Maternal exposure before pregnancy 12.15 11.74 166 910021 6657 55375223
Lung adenocarcinoma stage III 12.14 11.74 6 910181 13 55381867
Gallbladder disorder 12.12 11.74 202 909985 17132 55364748
Hypertonic bladder 12.11 11.74 21 910166 3211 55378669
Blood potassium abnormal 12.11 11.74 12 910175 2333 55379547
Carbon dioxide decreased 12.10 11.74 8 910179 1904 55379976
Skin mass 12.10 11.74 136 910051 5208 55376672
Hypopnoea 12.08 11.74 13 910174 2432 55379448
Anion gap increased 12.02 11.74 5 910182 1546 55380334
Anticonvulsant drug level increased 11.98 11.74 4 910183 1417 55380463
Nasopharyngeal cancer 11.96 11.74 7 910180 24 55381856
Intervertebral disc compression 11.95 11.74 39 910148 942 55380938
Local reaction 11.95 11.74 30 910157 621 55381259
Lip squamous cell carcinoma 11.95 11.74 14 910173 150 55381730
Antithrombin III decreased 11.94 11.74 17 910170 224 55381656
Chemotherapeutic drug level increased 11.91 11.74 13 910174 128 55381752
Bursitis infective staphylococcal 11.91 11.74 8 910179 37 55381843
Mucosal necrosis 11.91 11.74 8 910179 37 55381843
Gastroenteritis norovirus 11.89 11.74 60 910127 1777 55380103
Infusion site reaction 11.89 11.74 84 910103 2814 55379066
Endometrial adenocarcinoma 11.88 11.74 45 910142 1173 55380707
Focal dyscognitive seizures 11.88 11.74 17 910170 2808 55379072
Enuresis 11.87 11.74 12 910175 2311 55379569
Myxoid liposarcoma 11.86 11.74 5 910182 6 55381874
Bone sarcoma 11.85 11.74 6 910181 14 55381866
Molluscum contagiosum 11.84 11.74 16 910171 200 55381680
Hepatic necrosis 11.83 11.74 45 910142 5271 55376609
Ovarian epithelial cancer 11.81 11.74 20 910167 309 55381571
Follicular lymphoma 11.81 11.74 12 910175 108 55381772
Product container issue 11.80 11.74 5 910182 1529 55380351
Stupor 11.79 11.74 30 910157 3988 55377892
Medical device pain 11.77 11.74 5 910182 1527 55380353
Anaplastic thyroid cancer 11.75 11.74 8 910179 38 55381842

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 4410.51 11.54 10807 292006 384766 31009765
Rheumatoid arthritis 3270.43 11.54 3082 299731 44727 31349804
Drug intolerance 1498.74 11.54 2149 300664 49884 31344647
Joint swelling 1386.33 11.54 2101 300712 51330 31343201
Death 1367.83 11.54 885 301928 359684 31034847
Arthralgia 1060.32 11.54 3516 299297 147908 31246623
Treatment failure 1018.14 11.54 1576 301237 39216 31355315
Synovitis 1007.32 11.54 878 301935 11405 31383126
Psoriatic arthropathy 922.79 11.54 1042 301771 18841 31375690
Psoriasis 906.70 11.54 1612 301201 45107 31349424
Musculoskeletal stiffness 787.81 11.54 1415 301398 39910 31354621
Drug abuse 756.22 11.54 17 302796 87741 31306790
Therapeutic product effect incomplete 752.35 11.54 1432 301381 42264 31352267
Completed suicide 721.41 11.54 37 302776 91477 31303054
Therapeutic product effect decreased 648.17 11.54 1118 301695 30504 31364027
Mucosal inflammation 634.69 11.54 1162 301651 33265 31361266
Arthropathy 559.31 11.54 900 301913 23151 31371380
Acute graft versus host disease 541.34 11.54 458 302355 5695 31388836
Contraindicated product administered 527.02 11.54 788 302025 18984 31375547
Drug hypersensitivity 522.07 11.54 1703 301110 70896 31323635
Hypotension 487.75 11.54 751 302062 203867 31190664
Lymphoproliferative disorder 484.35 11.54 305 302508 2300 31392231
Arthritis 446.09 11.54 877 301936 26508 31368023
Constipation 421.33 11.54 340 302473 123651 31270880
Febrile neutropenia 420.92 11.54 2283 300530 119566 31274965
Leukoencephalopathy 409.70 11.54 322 302491 3580 31390951
Chronic graft versus host disease 398.90 11.54 333 302480 4059 31390472
Dyspnoea 398.14 11.54 1810 301003 341669 31052862
Stomatitis 382.33 11.54 1029 301784 38409 31356122
Rhabdomyolysis 378.10 11.54 74 302739 63507 31331024
Plasma cell myeloma 357.53 11.54 56 302757 56475 31338056
Hyperkalaemia 356.16 11.54 88 302725 64263 31330268
Bone erosion 355.52 11.54 280 302533 3123 31391408
Pain 349.29 11.54 3007 299806 183752 31210779
C-reactive protein abnormal 339.78 11.54 395 302418 7374 31387157
Posterior reversible encephalopathy syndrome 334.65 11.54 430 302383 8937 31385594
Fall 330.23 11.54 813 302000 185276 31209255
Dehydration 324.82 11.54 396 302417 118715 31275816
Drug clearance decreased 322.56 11.54 198 302615 1419 31393112
Dizziness 320.81 11.54 913 301900 198234 31196297
Confusional state 313.81 11.54 493 302320 132841 31261690
Graft versus host disease 290.76 11.54 425 302388 10022 31384509
Acute kidney injury 274.09 11.54 1561 301252 278153 31116378
Cardiac arrest 271.49 11.54 270 302543 88792 31305739
Bradycardia 271.19 11.54 163 302650 69164 31325367
Acute graft versus host disease in skin 269.19 11.54 279 302534 4553 31389978
Intentional overdose 261.69 11.54 41 302772 41348 31353183
Pancytopenia 259.21 11.54 1572 301241 85744 31308787
C-reactive protein increased 258.15 11.54 1034 301779 47616 31346915
Red blood cell sedimentation rate increased 258.03 11.54 357 302456 7989 31386542
Apparent death 256.58 11.54 238 302575 3367 31391164
Cardiac failure congestive 255.64 11.54 229 302584 79158 31315373
Venoocclusive liver disease 253.46 11.54 333 302480 7079 31387452
Syncope 249.71 11.54 267 302546 84915 31309616
International normalised ratio increased 240.37 11.54 67 302746 45156 31349375
Pulmonary fibrosis 239.78 11.54 507 302306 16153 31378378
Liver function test increased 237.76 11.54 432 302381 12282 31382249
Pain in extremity 234.90 11.54 1905 300908 114298 31280233
Pneumocystis jirovecii pneumonia 233.81 11.54 530 302283 17721 31376810
Osteoarthritis 229.20 11.54 540 302273 18527 31376004
Diarrhoea 229.06 11.54 2209 300604 350200 31044331
Somnolence 226.99 11.54 375 302438 99070 31295461
Atrial fibrillation 226.94 11.54 466 302347 113317 31281214
Electrocardiogram QT prolonged 226.23 11.54 44 302769 37943 31356588
Mobility decreased 225.42 11.54 675 302138 26794 31367737
Overdose 223.87 11.54 288 302525 84376 31310155
Anaemia 220.17 11.54 1171 301642 212351 31182180
Febrile bone marrow aplasia 219.51 11.54 320 302493 7526 31387005
Hypoglycaemia 219.37 11.54 106 302707 50840 31343691
Ankylosing spondylitis 216.42 11.54 274 302539 5607 31388924
Hyponatraemia 214.42 11.54 233 302580 73566 31320965
Red blood cell sedimentation rate abnormal 214.09 11.54 199 302614 2823 31391708
Decreased appetite 213.74 11.54 749 302064 152468 31242063
Epstein-Barr virus infection 212.83 11.54 296 302517 6657 31387874
Product use in unapproved indication 211.43 11.54 1646 301167 97525 31297006
Asthenia 208.89 11.54 1275 301538 223480 31171051
Myelopathy 207.57 11.54 172 302641 2073 31392458
Hospitalisation 204.94 11.54 110 302703 49697 31344834
Hallucination 203.77 11.54 94 302719 46316 31348215
Hand deformity 203.14 11.54 194 302619 2853 31391678
Off label use 200.75 11.54 4529 298284 342745 31051786
Malignant neoplasm progression 200.43 11.54 277 302536 78721 31315810
Hypofibrinogenaemia 196.30 11.54 145 302668 1458 31393073
Tuberculosis 195.00 11.54 313 302500 8028 31386503
Aggression 194.94 11.54 57 302756 37234 31357297
Inflammation 192.88 11.54 605 302208 24636 31369895
Gastrointestinal haemorrhage 191.42 11.54 308 302505 82241 31312290
Drug interaction 191.14 11.54 1188 301625 207355 31187176
Blood glucose increased 190.93 11.54 181 302632 60902 31333629
Fatigue 189.64 11.54 2170 300643 333036 31061495
Bone marrow failure 189.44 11.54 644 302169 27364 31367167
Joint stiffness 186.74 11.54 340 302473 9681 31384850
Epstein-Barr virus associated lymphoproliferative disorder 185.22 11.54 147 302666 1659 31392872
Agitation 184.45 11.54 148 302665 54021 31340510
Haemoglobin decreased 176.42 11.54 523 302290 112152 31282379
Lymphoma 176.36 11.54 349 302464 10594 31383937
Cardio-respiratory arrest 174.04 11.54 143 302670 51583 31342948
Basal cell carcinoma 172.74 11.54 471 302342 17708 31376823
Diffuse large B-cell lymphoma 172.33 11.54 302 302511 8339 31386192
Diverticulitis 170.16 11.54 476 302337 18169 31376362
Suicide attempt 167.34 11.54 73 302740 37175 31357356
Rheumatoid nodule 166.16 11.54 164 302649 2517 31392014
Knee arthroplasty 164.25 11.54 254 302559 6304 31388227
Loss of consciousness 163.50 11.54 306 302507 77049 31317482
Neurotoxicity 161.82 11.54 428 302385 15798 31378733
Blood creatine phosphokinase increased 159.50 11.54 102 302711 41872 31352659
Haematotoxicity 156.25 11.54 260 302553 6877 31387654
Loss of personal independence in daily activities 155.43 11.54 608 302205 27680 31366851
Sedation 154.78 11.54 6 302807 18959 31375572
Nodule 150.44 11.54 226 302587 5464 31389067
Acute lymphocytic leukaemia recurrent 150.16 11.54 168 302645 3002 31391529
Gastrointestinal disorder 149.45 11.54 635 302178 30025 31364506
Neuroleptic malignant syndrome 146.24 11.54 3 302810 16866 31377665
Angiocentric lymphoma 145.80 11.54 68 302745 253 31394278
Graft versus host disease in gastrointestinal tract 144.01 11.54 172 302641 3307 31391224
Infection 143.23 11.54 1301 301512 80630 31313901
Anxiety 142.85 11.54 422 302391 90611 31303920
Polyarthritis 136.13 11.54 185 302628 4067 31390464
Histoplasmosis disseminated 136.00 11.54 103 302710 1079 31393452
Dactylitis 135.30 11.54 90 302723 753 31393778
Suicidal ideation 134.90 11.54 91 302722 36315 31358216
Haemophagocytic lymphohistiocytosis 133.07 11.54 324 302489 11354 31383177
Mouth ulceration 132.28 11.54 309 302504 10539 31383992
Foetal exposure during pregnancy 131.41 11.54 118 302695 40758 31353773
Metabolic acidosis 131.17 11.54 111 302702 39466 31355065
Pneumonia aspiration 130.33 11.54 107 302706 38619 31355912
Cystitis haemorrhagic 127.10 11.54 201 302612 5088 31389443
Acute graft versus host disease in intestine 126.79 11.54 138 302675 2388 31392143
Grip strength decreased 126.66 11.54 141 302672 2505 31392026
Joint range of motion decreased 126.65 11.54 228 302585 6433 31388098
Disability 125.91 11.54 187 302626 4474 31390057
Joint effusion 124.93 11.54 185 302628 4414 31390117
Foot deformity 124.55 11.54 175 302638 3974 31390557
Pulmonary tuberculosis 124.39 11.54 187 302626 4524 31390007
Blood creatinine increased 124.37 11.54 435 302378 88643 31305888
Sarcoidosis 124.36 11.54 142 302671 2597 31391934
Hypokalaemia 124.04 11.54 200 302613 53374 31341157
Cardiac failure 123.21 11.54 415 302398 85538 31308993
Graft versus host disease in skin 122.04 11.54 161 302652 3436 31391095
Coma 121.61 11.54 128 302685 41022 31353509
Drug reaction with eosinophilia and systemic symptoms 120.99 11.54 68 302745 29950 31364581
Product dose omission issue 118.89 11.54 561 302252 105025 31289506
Skin plaque 117.05 11.54 167 302646 3848 31390683
Rheumatoid factor positive 116.01 11.54 76 302737 618 31393913
Herpes zoster 115.27 11.54 607 302206 31386 31363145
Arthritis bacterial 113.86 11.54 177 302636 4413 31390118
Enthesopathy 112.95 11.54 170 302643 4117 31390414
Product use issue 112.05 11.54 926 301887 55833 31338698
Delirium 110.35 11.54 140 302673 41281 31353250
Lactic acidosis 110.28 11.54 86 302727 31851 31362680
Synovial cyst 109.25 11.54 116 302697 1949 31392582
Intentional product misuse 107.77 11.54 122 302691 37829 31356702
Therapeutic response decreased 107.49 11.54 520 302293 25989 31368542
Hepatic enzyme increased 107.35 11.54 648 302165 35260 31359271
Immunosuppression 106.31 11.54 192 302621 5431 31389100
Impaired work ability 105.21 11.54 196 302617 5681 31388850
Visceral leishmaniasis 104.74 11.54 65 302748 476 31394055
Condition aggravated 104.48 11.54 2171 300642 161838 31232693
Cerebrovascular accident 104.45 11.54 398 302415 79086 31315445
Toxicity to various agents 104.15 11.54 1170 301643 180317 31214214
Tenosynovitis 103.95 11.54 162 302651 4048 31390483
Abnormal behaviour 103.43 11.54 49 302764 23779 31370752
Respiratory arrest 100.85 11.54 63 302750 26194 31368337
Swelling 100.37 11.54 656 302157 36702 31357829
Tremor 100.19 11.54 383 302430 76037 31318494
Cutaneous leishmaniasis 98.46 11.54 46 302767 172 31394359
Epidermal necrosis 98.28 11.54 59 302754 404 31394127
Depressed level of consciousness 98.20 11.54 135 302678 38466 31356065
Orthostatic hypotension 98.12 11.54 54 302759 24065 31370466
Uveitis 97.56 11.54 207 302606 6609 31387922
Chondropathy 97.37 11.54 77 302736 864 31393667
Drug withdrawal syndrome 97.36 11.54 29 302784 18721 31375810
Sopor 96.56 11.54 3 302810 11549 31382982
Anti-cyclic citrullinated peptide antibody positive 95.78 11.54 91 302722 1329 31393202
Serotonin syndrome 95.74 11.54 30 302783 18743 31375788
Nasopharyngitis 95.52 11.54 974 301839 62271 31332260
Tuberculin test positive 95.38 11.54 82 302731 1043 31393488
Sleep disorder due to general medical condition, insomnia type 95.31 11.54 87 302726 1204 31393327
Respiratory depression 94.88 11.54 13 302800 14497 31380034
Hepatotoxicity 94.64 11.54 398 302415 18728 31375803
Cardiogenic shock 94.35 11.54 48 302765 22360 31372171
Epstein Barr virus positive mucocutaneous ulcer 93.63 11.54 52 302761 301 31394230
Chest pain 93.60 11.54 693 302120 116264 31278267
Sacroiliitis 93.45 11.54 88 302725 1270 31393261
Platelet count decreased 91.93 11.54 647 302166 109788 31284743
Inappropriate schedule of product administration 91.80 11.54 813 302000 50010 31344521
Central nervous system lymphoma 89.40 11.54 79 302734 1045 31393486
Squamous cell carcinoma 88.59 11.54 264 302549 10447 31384084
Acute myocardial infarction 86.82 11.54 226 302587 50597 31343934
Injection site pain 86.33 11.54 597 302216 34037 31360494
Myocardial infarction 85.26 11.54 684 302129 112770 31281761
Juvenile idiopathic arthritis 84.07 11.54 93 302720 1640 31392891
Hypocalcaemia 84.04 11.54 53 302760 21925 31372606
Psychotic disorder 83.55 11.54 55 302758 22238 31372293
Multiple sclerosis relapse 83.17 11.54 9 302804 12038 31382493
Restlessness 83.10 11.54 61 302752 23300 31371231
Unevaluable event 82.84 11.54 102 302711 30473 31364058
Intentional self-injury 82.33 11.54 14 302799 13301 31381230
Rheumatoid factor negative 81.90 11.54 67 302746 792 31393739
Drug specific antibody present 81.81 11.54 118 302695 2747 31391784
Oedema peripheral 81.71 11.54 664 302149 109175 31285356
Hypomagnesaemia 81.48 11.54 40 302773 19018 31375513
Peripheral swelling 81.02 11.54 998 301815 66867 31327664
Hyperglycaemia 79.96 11.54 141 302672 36335 31358196
Skin ulcer 79.56 11.54 390 302423 19595 31374936
Blood urea increased 79.43 11.54 96 302717 28916 31365615
Spermatozoa abnormal 79.41 11.54 27 302786 29 31394502
Blood pressure fluctuation 78.91 11.54 427 302386 22309 31372222
Urinary retention 78.90 11.54 125 302688 33600 31360931
Musculoskeletal pain 78.43 11.54 521 302292 29307 31365224
Delusion 77.85 11.54 11 302802 11986 31382545
Chronic kidney disease 77.76 11.54 153 302660 37822 31356709
Extrapyramidal disorder 75.96 11.54 11 302802 11767 31382764
Oxidative stress 75.07 11.54 27 302786 39 31394492
Melaena 74.54 11.54 123 302690 32531 31362000
Abscess 73.42 11.54 244 302569 10243 31384288
Vomiting 73.09 11.54 1607 301206 222366 31172165
Hip arthroplasty 73.07 11.54 136 302677 3939 31390592
Diabetic ketoacidosis 73.00 11.54 35 302778 16870 31377661
Epstein-Barr virus infection reactivation 72.92 11.54 62 302751 776 31393755
Chemotherapeutic drug level increased 72.69 11.54 37 302776 174 31394357
Cytomegalovirus infection 72.65 11.54 444 302369 24263 31370268
Nightmare 72.37 11.54 14 302799 12123 31382408
Cardiac disorder 71.96 11.54 168 302645 39046 31355485
Bone cyst 71.91 11.54 71 302742 1090 31393441
General physical health deterioration 71.58 11.54 715 302098 112720 31281811
Angioedema 70.97 11.54 133 302680 33485 31361046
Acute lymphocytic leukaemia 70.51 11.54 123 302690 3383 31391148
Coronary artery disease 69.83 11.54 217 302596 45870 31348661
Musculoskeletal discomfort 69.76 11.54 185 302628 6838 31387693
Myalgia 69.59 11.54 442 302371 76816 31317715
X-ray abnormal 69.49 11.54 48 302765 430 31394101
Disseminated tuberculosis 69.37 11.54 95 302718 2104 31392427
Mycobacterium tuberculosis complex test positive 69.18 11.54 69 302744 1073 31393458
Venoocclusive disease 69.03 11.54 105 302708 2567 31391964
Malignant melanoma 68.58 11.54 195 302618 7512 31387019
Renal impairment 68.40 11.54 513 302300 85836 31308695
Hallucination, visual 67.75 11.54 33 302780 15761 31378770
Leukaemia recurrent 67.62 11.54 80 302733 1522 31393009
Pulmonary toxicity 67.57 11.54 155 302658 5222 31389309
Blood potassium increased 67.45 11.54 31 302782 15314 31379217
Vein rupture 67.33 11.54 57 302756 709 31393822
Pulmonary mass 67.02 11.54 249 302564 11057 31383474
Sensitivity to weather change 66.77 11.54 77 302736 1424 31393107
Disease progression 66.75 11.54 548 302265 89916 31304615
Skin lesion 66.59 11.54 365 302448 19162 31375369
Dislocation of vertebra 66.26 11.54 45 302768 391 31394140
Dysgeusia 66.00 11.54 76 302737 23390 31371141
Foetal methotrexate syndrome 65.89 11.54 18 302795 0 31394531
Full blood count decreased 65.88 11.54 38 302775 16502 31378029
Bladder transitional cell carcinoma 65.71 11.54 100 302713 2446 31392085
Atlantoaxial instability 65.66 11.54 41 302772 304 31394227
Mucocutaneous ulceration 65.19 11.54 32 302781 137 31394394
Latent tuberculosis 65.18 11.54 69 302744 1155 31393376
Haematocrit decreased 65.17 11.54 117 302696 29944 31364587
Finger deformity 65.13 11.54 69 302744 1156 31393375
Myoclonus 65.10 11.54 26 302787 13964 31380567
Cytomegalovirus chorioretinitis 64.74 11.54 117 302696 3311 31391220
Balance disorder 64.22 11.54 166 302647 37256 31357275
Product quality issue 64.19 11.54 37 302776 16074 31378457
Haematemesis 63.96 11.54 91 302722 25562 31368969
Spinal instability 63.54 11.54 41 302772 324 31394207
Wrist deformity 63.54 11.54 41 302772 324 31394207
Abdominal distension 63.23 11.54 259 302554 50425 31344106
Injury 63.20 11.54 57 302756 19652 31374879
Joint ankylosis 63.13 11.54 64 302749 1016 31393515
Tachycardia 63.12 11.54 447 302366 75760 31318771
Dyskinesia 62.94 11.54 64 302749 20846 31373685
Miosis 62.90 11.54 5 302808 8565 31385966
Mineral metabolism disorder 62.82 11.54 41 302772 331 31394200
Haemorrhage 62.81 11.54 236 302577 47098 31347433
Hepatic steatosis 62.58 11.54 314 302499 15925 31378606
Blood pressure decreased 62.37 11.54 242 302571 47849 31346682
Sinus bradycardia 62.20 11.54 19 302794 12068 31382463
Urinary tract infection 62.16 11.54 454 302359 76415 31318116
Limb discomfort 61.82 11.54 227 302586 10022 31384509
Cytogenetic abnormality 61.75 11.54 56 302757 768 31393763
Depression 61.71 11.54 562 302251 90253 31304278
Complications of bone marrow transplant 61.33 11.54 34 302779 196 31394335
Intentional product use issue 61.19 11.54 731 302082 48616 31345915
Demyelination 61.17 11.54 105 302708 2850 31391681
Disorientation 61.12 11.54 126 302687 30618 31363913
Blood potassium decreased 60.92 11.54 41 302772 16385 31378146
Insomnia 60.55 11.54 596 302217 94240 31300291
Histoplasmosis 60.53 11.54 71 302742 1338 31393193
Dystonia 60.53 11.54 12 302801 10213 31384318
Stevens-Johnson syndrome 59.69 11.54 47 302766 17325 31377206
Haematuria 59.46 11.54 234 302579 46080 31348451
Pleurisy 59.31 11.54 131 302682 4301 31390230
Faecal calprotectin increased 58.05 11.54 81 302732 1827 31392704
Lymphadenopathy 58.02 11.54 438 302375 25683 31368848
Atrial flutter 57.90 11.54 34 302779 14621 31379910
Oedema 57.25 11.54 211 302602 42350 31352181
Cutaneous T-cell lymphoma 57.16 11.54 69 302744 1342 31393189
Fear of injection 57.04 11.54 65 302748 1186 31393345
Cytomegalovirus infection reactivation 57.01 11.54 120 302693 3809 31390722
Adenovirus infection 56.41 11.54 134 302679 4620 31389911
Anal fistula 55.88 11.54 134 302679 4649 31389882
Bursitis 55.38 11.54 138 302675 4907 31389624
Clinodactyly 55.20 11.54 33 302780 224 31394307
Cognitive disorder 54.93 11.54 96 302717 24827 31369704
Aplasia 54.86 11.54 123 302690 4080 31390451
Disease recurrence 54.64 11.54 335 302478 18326 31376205
Erectile dysfunction 54.42 11.54 62 302751 19173 31375358
Ventricular tachycardia 54.35 11.54 89 302724 23612 31370919
Medial tibial stress syndrome 54.26 11.54 19 302794 24 31394507
Chronic graft versus host disease in skin 54.23 11.54 54 302759 838 31393693
Kidney transplant rejection 54.15 11.54 4 302809 7278 31387253
Wheezing 54.12 11.54 170 302643 35816 31358715
Acute graft versus host disease in liver 54.03 11.54 67 302746 1341 31393190
Angioimmunoblastic T-cell lymphoma 53.97 11.54 37 302776 327 31394204
Drug ineffective for unapproved indication 53.76 11.54 322 302491 17468 31377063
Paranoia 53.58 11.54 17 302796 10538 31383993
Joint destruction 53.39 11.54 35 302778 285 31394246
Fluid retention 53.34 11.54 97 302716 24705 31369826
Abscess limb 53.20 11.54 106 302707 3233 31391298
Pulmonary hypertension 53.09 11.54 68 302745 19973 31374558
Onychoclasis 52.82 11.54 75 302738 1720 31392811
Neuropathy peripheral 52.76 11.54 465 302348 75184 31319347
Seizure 52.57 11.54 655 302158 99113 31295418
Irritability 52.44 11.54 86 302727 22803 31371728
Hypertriglyceridaemia 52.43 11.54 179 302634 7619 31386912
Schizophrenia 52.27 11.54 19 302794 10811 31383720
Blood glucose decreased 52.07 11.54 27 302786 12444 31382087
Haemoptysis 52.06 11.54 147 302666 32042 31362489
Seronegative arthritis 51.94 11.54 55 302758 921 31393610
Aphthous ulcer 51.90 11.54 125 302688 4349 31390182
Lung neoplasm malignant 51.78 11.54 298 302515 15932 31378599
Engraftment syndrome 51.56 11.54 53 302760 856 31393675
Pneumonia legionella 51.40 11.54 72 302741 1630 31392901
Thrombotic microangiopathy 51.35 11.54 201 302612 9150 31385381
Acne cystic 51.21 11.54 41 302772 469 31394062
Vision blurred 51.16 11.54 216 302597 41699 31352832
Akathisia 51.15 11.54 5 302808 7248 31387283
Pulmonary oedema 50.88 11.54 235 302578 44267 31350264
Mycobacterial infection 50.83 11.54 83 302730 2160 31392371
Blood sodium decreased 50.67 11.54 43 302770 15272 31379259
Swollen tongue 50.59 11.54 30 302783 12832 31381699
Superior sagittal sinus thrombosis 50.52 11.54 32 302781 244 31394287
Squamous cell carcinoma of lung 50.29 11.54 75 302738 1801 31392730
Unresponsive to stimuli 49.39 11.54 108 302705 25692 31368839
B-cell lymphoma 49.23 11.54 122 302691 4323 31390208
Colitis ulcerative 48.91 11.54 324 302489 18205 31376326
Mental status changes 48.58 11.54 178 302635 35790 31358741
Wrong technique in product usage process 48.41 11.54 160 302653 33183 31361348
Rash maculo-papular 48.14 11.54 109 302704 25610 31368921
Anhedonia 47.88 11.54 7 302806 7435 31387096
Spondyloarthropathy 47.87 11.54 42 302771 550 31393981
Intervertebral disc space narrowing 47.81 11.54 52 302761 899 31393632
Skin cancer 47.76 11.54 197 302616 9188 31385343
Flushing 47.68 11.54 139 302674 29989 31364542
Rash 47.63 11.54 1514 301299 199972 31194559
Rheumatoid lung 47.53 11.54 47 302766 723 31393808
Erythrodermic psoriasis 47.34 11.54 49 302764 798 31393733
Poisoning deliberate 47.03 11.54 7 302806 7337 31387194
White blood cell count increased 46.97 11.54 202 302611 38798 31355733
Muscle rigidity 46.70 11.54 18 302795 9879 31384652
Fibromyalgia 46.58 11.54 91 302722 2735 31391796
Injection site haemorrhage 46.46 11.54 191 302622 8894 31385637
Alanine aminotransferase abnormal 46.19 11.54 111 302702 3856 31390675
Viral haemorrhagic cystitis 46.05 11.54 53 302760 978 31393553
Joint arthroplasty 45.92 11.54 47 302766 755 31393776
Arthritis infective 45.89 11.54 93 302720 2872 31391659
Ventricular fibrillation 45.86 11.54 68 302745 18780 31375751
Post transplant lymphoproliferative disorder 45.81 11.54 145 302668 5931 31388600
Hyperhidrosis 45.79 11.54 417 302396 66976 31327555
Hepatic fibrosis 45.76 11.54 109 302704 3765 31390766
Hepatic encephalopathy 45.70 11.54 38 302775 13633 31380898
Hepatic cirrhosis 45.65 11.54 281 302532 15393 31379138
Intestinal polyp 45.63 11.54 51 302762 910 31393621
Treatment noncompliance 45.56 11.54 112 302701 25572 31368959
Arrhythmia 45.13 11.54 163 302650 32914 31361617
Dry mouth 44.69 11.54 105 302708 24353 31370178
Cerebral haemorrhage 44.57 11.54 162 302651 32650 31361881
Dysphagia 44.54 11.54 345 302468 57331 31337200
Troponin increased 44.28 11.54 20 302793 9982 31384549
Peritonitis bacterial 44.14 11.54 3 302810 5849 31388682
Fear 44.07 11.54 20 302793 9954 31384577
Red blood cell count decreased 43.66 11.54 122 302691 26685 31367846
Palpitations 43.58 11.54 176 302637 34407 31360124
Transient ischaemic attack 43.38 11.54 104 302709 23952 31370579
Pericarditis 43.11 11.54 190 302623 9126 31385405
Osteonecrosis 43.04 11.54 253 302560 13631 31380900
Photosensitivity reaction 42.85 11.54 198 302615 9706 31384825
Subdural haematoma 42.79 11.54 72 302741 18899 31375632
Immunodeficiency 42.73 11.54 120 302693 4589 31389942
Therapy partial responder 42.70 11.54 149 302664 6413 31388118
Drug eruption 42.68 11.54 309 302504 17878 31376653
Poisoning 42.64 11.54 23 302790 10368 31384163
Hypersensitivity 42.58 11.54 759 302054 54984 31339547
Myelosuppression 42.52 11.54 266 302547 14654 31379877
Haematoma 42.24 11.54 106 302707 24033 31370498
Graft versus host disease in liver 42.24 11.54 54 302759 1116 31393415
Joint lock 42.16 11.54 54 302759 1118 31393413
Lupus-like syndrome 41.93 11.54 81 302732 2414 31392117
Therapeutic response shortened 41.92 11.54 137 302676 5700 31388831
Hypovolaemia 41.59 11.54 14 302799 8358 31386173
Tardive dyskinesia 41.49 11.54 3 302810 5556 31388975
Ill-defined disorder 41.49 11.54 233 302580 12344 31382187
Lymph node tuberculosis 41.36 11.54 35 302778 435 31394096
End stage renal disease 41.27 11.54 13 302800 8096 31386435
Upper gastrointestinal haemorrhage 41.19 11.54 101 302712 23082 31371449
Osteonecrosis of jaw 41.14 11.54 62 302751 17009 31377522
Therapy non-responder 41.09 11.54 499 302314 33312 31361219
Lung disorder 41.08 11.54 481 302332 31831 31362700
Injection site bruising 41.05 11.54 168 302645 7807 31386724
Clear cell renal cell carcinoma 40.97 11.54 51 302762 1025 31393506
Asthma 40.85 11.54 239 302574 42372 31352159
Ileal stenosis 40.71 11.54 55 302758 1202 31393329
Disturbance in attention 40.53 11.54 97 302716 22353 31372178
Premature baby 40.35 11.54 69 302744 17997 31376534
Injection site swelling 40.25 11.54 197 302616 9890 31384641
Hyperthyroidism 39.99 11.54 21 302792 9610 31384921
Liver disorder 39.91 11.54 447 302366 29260 31365271
Tenderness 39.79 11.54 136 302677 5792 31388739
Progressive multifocal leukoencephalopathy 39.72 11.54 184 302629 9029 31385502
Pustular psoriasis 39.61 11.54 62 302751 1555 31392976
Hallucination, auditory 39.58 11.54 25 302788 10335 31384196
Faeces discoloured 39.48 11.54 44 302769 13742 31380789
Angina pectoris 39.17 11.54 148 302665 29493 31365038
Tooth fracture 39.12 11.54 94 302719 3265 31391266
Arachnoiditis 39.02 11.54 30 302783 322 31394209
Decreased immune responsiveness 38.98 11.54 59 302754 1436 31393095
Frequent bowel movements 38.83 11.54 196 302617 9963 31384568
Labelled drug-drug interaction medication error 38.81 11.54 41 302772 13122 31381409
Interstitial lung disease 38.71 11.54 812 302001 60591 31333940
Central nervous system leukaemia 38.45 11.54 27 302786 249 31394282
Molluscum contagiosum 38.19 11.54 27 302786 252 31394279
Glioma 38.13 11.54 30 302783 334 31394197
Mania 38.12 11.54 20 302793 9157 31385374
Peritoneal tuberculosis 37.84 11.54 30 302783 338 31394193
Amnesia 37.74 11.54 107 302706 23295 31371236
Withdrawal syndrome 37.43 11.54 34 302779 11683 31382848
Oral herpes 37.39 11.54 117 302696 4756 31389775
Scleroderma 37.36 11.54 56 302757 1351 31393180
Device occlusion 37.14 11.54 6 302807 5919 31388612
Contraindication to medical treatment 37.01 11.54 37 302776 577 31393954
Aspiration 37.01 11.54 29 302784 10717 31383814
Non-Hodgkin's lymphoma 36.67 11.54 59 302754 1516 31393015
Lymphocyte count decreased 36.66 11.54 90 302723 20559 31373972
Mass 36.61 11.54 153 302660 7178 31387353
Oral disorder 36.55 11.54 101 302712 3826 31390705
Memory impairment 36.48 11.54 214 302599 37916 31356615
Incorrect disposal of product 36.46 11.54 28 302785 300 31394231
Acute promyelocytic leukaemia 36.42 11.54 34 302779 485 31394046
Pulmonary thrombosis 36.20 11.54 146 302667 6739 31387792
Blood calcium decreased 36.15 11.54 23 302790 9471 31385060
Inflammatory bowel disease 36.12 11.54 77 302736 2466 31392065
Hypoxia 36.08 11.54 307 302506 50006 31344525
Hiccups 36.05 11.54 22 302791 9265 31385266
Hyperbilirubinaemia 36.05 11.54 266 302547 15484 31379047
Cerebral venous sinus thrombosis 35.87 11.54 32 302781 429 31394102
Cytomegalovirus viraemia 35.68 11.54 143 302670 6582 31387949
Cytology abnormal 35.64 11.54 30 302783 370 31394161
Eosinophilia 35.56 11.54 109 302704 23144 31371387
Pneumonia cryptococcal 35.38 11.54 42 302771 802 31393729
Jaundice 35.18 11.54 159 302654 30128 31364403
Craniosynostosis 35.06 11.54 28 302785 319 31394212
Drug tolerance decreased 35.04 11.54 62 302751 1725 31392806
Osteopenia 34.90 11.54 108 302705 4363 31390168
Intervertebral discitis 34.78 11.54 64 302749 1837 31392694
Speech disorder 34.53 11.54 117 302696 24084 31370447
Right ventricular failure 34.48 11.54 18 302795 8264 31386267
Hypervolaemia 34.44 11.54 77 302736 18174 31376357
Epstein-Barr viraemia 34.33 11.54 46 302767 997 31393534
Chromaturia 34.32 11.54 46 302767 13252 31381279
Head injury 34.19 11.54 67 302746 16591 31377940
White blood cell count decreased 34.18 11.54 608 302205 86790 31307741
Tubulointerstitial nephritis 34.12 11.54 79 302734 18417 31376114
Depressed mood 34.11 11.54 73 302740 17502 31377029
Oral mucosa erosion 34.09 11.54 42 302771 835 31393696
Arthrodesis 33.96 11.54 31 302782 429 31394102
Hepatic enzyme abnormal 33.90 11.54 73 302740 2355 31392176
Minimal residual disease 33.88 11.54 28 302785 336 31394195
Salivary hypersecretion 33.85 11.54 16 302797 7776 31386755
Spinal pain 33.84 11.54 118 302695 5077 31389454
Facial paralysis 33.76 11.54 186 302627 9783 31384748
Cytotoxic oedema 33.71 11.54 21 302792 155 31394376
Presyncope 33.61 11.54 72 302741 17256 31377275
Terminal ileitis 33.55 11.54 20 302793 135 31394396
Staphylococcal sepsis 33.33 11.54 174 302639 8963 31385568
Gingivitis ulcerative 33.24 11.54 14 302799 38 31394493
Heart rate increased 33.11 11.54 243 302570 40867 31353664
Impaired healing 33.10 11.54 240 302573 13892 31380639
Osteosarcoma 32.77 11.54 25 302788 265 31394266
Inflammatory marker increased 32.69 11.54 101 302712 4077 31390454
Vertigo 32.67 11.54 112 302701 22973 31371558
Blood stem cell transplant failure 32.49 11.54 29 302784 389 31394142
Rheumatoid factor increased 32.49 11.54 33 302780 525 31394006
Full blood count abnormal 32.48 11.54 67 302746 16280 31378251
Dysuria 32.30 11.54 121 302692 24173 31370358
Chronic obstructive pulmonary disease 32.20 11.54 276 302537 44890 31349641
Failure to thrive 32.13 11.54 18 302795 7944 31386587
Atrial septal defect 32.02 11.54 13 302800 6914 31387617
Palmar-plantar erythrodysaesthesia syndrome 32.02 11.54 62 302751 15421 31379110
Blood fibrinogen decreased 31.93 11.54 47 302766 1115 31393416
Supraventricular tachycardia 31.65 11.54 31 302782 10276 31384255
Bursitis infective 31.47 11.54 33 302780 546 31393985
Lethargy 31.32 11.54 228 302585 38413 31356118
Acute myeloid leukaemia 31.30 11.54 294 302519 18378 31376153
Electrocardiogram abnormal 31.24 11.54 19 302794 8017 31386514
Bronchial carcinoma 31.18 11.54 42 302771 915 31393616
Psychomotor hyperactivity 31.17 11.54 23 302790 8764 31385767
Exposure during pregnancy 31.16 11.54 22 302791 8576 31385955
Dyspnoea exertional 31.07 11.54 230 302583 38607 31355924
Metastatic bronchial carcinoma 30.99 11.54 23 302790 233 31394298
Cutaneous lymphoma 30.98 11.54 16 302797 78 31394453
Oropharyngeal pain 30.92 11.54 447 302366 31036 31363495
Shock haemorrhagic 30.80 11.54 31 302782 10146 31384385
Myelodysplastic syndrome 30.73 11.54 300 302513 18951 31375580
Obliterative bronchiolitis 30.72 11.54 47 302766 1155 31393376
Engraft failure 30.60 11.54 29 302784 422 31394109
Venous injury 30.59 11.54 24 302789 266 31394265
Brain natriuretic peptide increased 30.43 11.54 5 302808 4871 31389660
Poor venous access 30.42 11.54 97 302716 3983 31390548
Synovial disorder 30.32 11.54 21 302792 189 31394342
Complications of transplanted kidney 30.28 11.54 3 302810 4302 31390229
Syringe issue 30.26 11.54 5 302808 4851 31389680
Cardiac failure chronic 30.21 11.54 16 302797 7287 31387244
Tonsil cancer 30.16 11.54 43 302770 990 31393541
T-cell lymphoma 30.14 11.54 42 302771 946 31393585
Thinking abnormal 30.08 11.54 8 302805 5565 31388966
Gastric disorder 30.07 11.54 201 302612 11327 31383204
Mucormycosis 30.00 11.54 119 302694 5451 31389080
Altered state of consciousness 29.88 11.54 102 302711 20949 31373582
Myelitis transverse 29.72 11.54 43 302770 1004 31393527
Bundle branch block right 29.63 11.54 15 302798 7009 31387522
Atrioventricular block first degree 29.55 11.54 9 302804 5728 31388803
Fungal infection 29.55 11.54 239 302574 14312 31380219
Acute myeloid leukaemia recurrent 29.47 11.54 61 302752 1913 31392618
Transaminases increased 29.47 11.54 359 302454 23982 31370549
Osteolysis 29.38 11.54 67 302746 2248 31392283
Lung cancer metastatic 29.36 11.54 72 302741 2534 31391997
Pleuropericarditis 29.10 11.54 21 302792 203 31394328
Colitis 28.99 11.54 470 302343 33417 31361114
Bladder transitional cell carcinoma recurrent 28.98 11.54 18 302795 132 31394399
Hypothermia 28.96 11.54 29 302784 9515 31385016
Skin mass 28.87 11.54 88 302725 3526 31391005
Obsessive-compulsive disorder 28.80 11.54 6 302807 4931 31389600
Soft tissue swelling 28.64 11.54 26 302787 357 31394174
No adverse event 28.60 11.54 94 302719 19531 31375000
Therapeutic product effect delayed 28.57 11.54 45 302768 1135 31393396
Skin erosion 28.47 11.54 58 302755 1798 31392733
Osteosclerosis 28.45 11.54 46 302767 1187 31393344
Gastric haemorrhage 28.40 11.54 31 302782 9774 31384757
Atrioventricular block complete 28.39 11.54 24 302789 8541 31385990
Serum procollagen type III N-terminal propeptide increased 28.36 11.54 13 302800 46 31394485
Priapism 28.25 11.54 5 302808 4615 31389916
Cerebral salt-wasting syndrome 28.15 11.54 13 302800 47 31394484
Bone tuberculosis 28.09 11.54 25 302788 334 31394197
Hypophosphataemia 28.05 11.54 24 302789 8490 31386041
Ankle deformity 28.04 11.54 21 302792 216 31394315
Gastrointestinal toxicity 27.97 11.54 65 302748 2209 31392322
Localised infection 27.96 11.54 245 302568 15020 31379511
Axial spondyloarthritis 27.91 11.54 25 302788 337 31394194
Glycosylated haemoglobin increased 27.84 11.54 35 302778 10365 31384166
Abdominal discomfort 27.80 11.54 667 302146 50900 31343631
Blood loss anaemia 27.65 11.54 20 302793 7699 31386832
Pseudostroke 27.63 11.54 12 302801 36 31394495
Tropical infectious disease 27.63 11.54 12 302801 36 31394495
Pachymeningitis 27.57 11.54 16 302797 102 31394429
Anger 27.37 11.54 40 302773 11113 31383418
Mucosal ulceration 27.32 11.54 39 302774 899 31393632
Bronchospasm 27.29 11.54 33 302780 9939 31384592
Sudden death 27.27 11.54 61 302752 14396 31380135
Cytomegalovirus test positive 27.15 11.54 86 302727 3519 31391012
Pyoderma gangrenosum 27.14 11.54 47 302766 1285 31393246
Bone marrow oedema 27.12 11.54 30 302783 529 31394002
Non-alcoholic steatohepatitis 27.10 11.54 37 302776 817 31393714
Lipoma 27.05 11.54 51 302762 1492 31393039
Myelitis 27.02 11.54 36 302777 776 31393755
Device leakage 26.98 11.54 9 302804 5404 31389127
Food intolerance 26.91 11.54 46 302767 1244 31393287
Granulomatous pneumonitis 26.89 11.54 11 302802 27 31394504
Alopecia 26.71 11.54 309 302504 20386 31374145
Mucosal toxicity 26.67 11.54 21 302792 234 31394297
T-cell type acute leukaemia 26.64 11.54 19 302794 180 31394351
Pruritus 26.60 11.54 953 301860 124214 31270317
Bradyphrenia 26.43 11.54 5 302808 4399 31390132
Leukocytosis 26.34 11.54 115 302698 21999 31372532
Chemotherapeutic drug level above therapeutic 26.32 11.54 9 302804 10 31394521
Gliosis 26.26 11.54 18 302795 159 31394372
Acute myelomonocytic leukaemia 26.25 11.54 16 302797 113 31394418
Acidosis 26.08 11.54 34 302779 9912 31384619
Sweat gland tumour 26.03 11.54 26 302787 405 31394126
Chest discomfort 26.02 11.54 324 302489 49045 31345486
Abnormal dreams 26.01 11.54 18 302795 7090 31387441
Bicytopenia 26.01 11.54 60 302753 2029 31392502
Hypoxic-ischaemic encephalopathy 25.90 11.54 5 302808 4336 31390195
Actinomycotic pulmonary infection 25.86 11.54 9 302804 11 31394520
Terminal state 25.84 11.54 86 302727 3612 31390919
Shock 25.63 11.54 120 302693 22525 31372006
Angioimmunoblastic T-cell lymphoma stage III 25.62 11.54 7 302806 0 31394531
Prostate cancer 25.60 11.54 503 302310 37098 31357433
Rheumatic disorder 25.58 11.54 29 302784 526 31394005
Pneumonia fungal 25.53 11.54 124 302689 6205 31388326
Tricuspid valve incompetence 25.48 11.54 28 302785 8801 31385730
Meningitis haemophilus 25.45 11.54 8 302805 5 31394526
Nodular regenerative hyperplasia 25.43 11.54 38 302775 914 31393617
Muscle spasticity 25.37 11.54 11 302802 5624 31388907
Glioblastoma multiforme 25.34 11.54 34 302779 738 31393793
Neutrophil count increased 25.31 11.54 72 302741 15659 31378872
Aspiration bone marrow abnormal 25.31 11.54 15 302798 100 31394431
Pollakiuria 25.23 11.54 87 302726 17815 31376716
Peritonsillar abscess 25.15 11.54 23 302790 319 31394212
Human herpesvirus 8 infection 25.15 11.54 36 302777 832 31393699
Anal abscess 25.12 11.54 116 302697 5684 31388847
Product substitution issue 24.98 11.54 32 302781 9400 31385131
Acute respiratory failure 24.98 11.54 161 302652 27894 31366637
Hepatitis cholestatic 24.97 11.54 19 302794 7127 31387404
Lentigo 24.91 11.54 24 302789 357 31394174
Aspergillus infection 24.86 11.54 192 302621 11336 31383195
Tooth loss 24.83 11.54 85 302728 3623 31390908
Neck pain 24.81 11.54 331 302482 22579 31371952
Intestinal sepsis 24.79 11.54 29 302784 545 31393986
Flatulence 24.78 11.54 95 302718 18853 31375678
Angina unstable 24.78 11.54 43 302770 11152 31383379
Herpes simplex oesophagitis 24.78 11.54 18 302795 176 31394355
Blood alkaline phosphatase increased 24.74 11.54 172 302641 29281 31365250
Bone sarcoma 24.60 11.54 13 302800 67 31394464
Parkinsonism 24.58 11.54 22 302791 7614 31386917
Graft versus host disease in eye 24.54 11.54 20 302793 235 31394296
Ageusia 24.36 11.54 32 302781 9299 31385232
Facial paresis 24.36 11.54 69 302744 2652 31391879
Granulocytopenia 24.31 11.54 14 302799 6085 31388446
Leukopenia 24.29 11.54 724 302089 57104 31337427
Ischaemic cardiomyopathy 24.28 11.54 13 302800 5884 31388647
Ependymoma malignant 24.26 11.54 9 302804 15 31394516
Varicella zoster virus infection 24.20 11.54 50 302763 1566 31392965
Cerebral venous thrombosis 24.20 11.54 31 302782 642 31393889
Drug dependence 24.19 11.54 122 302691 22457 31372074
Spondylitis 24.17 11.54 41 302772 1102 31393429
Prescribed underdose 24.16 11.54 26 302787 8252 31386279
Meningitis tuberculous 24.16 11.54 31 302782 643 31393888
Septic arthritis staphylococcal 24.15 11.54 27 302786 482 31394049
Joint tuberculosis 23.98 11.54 11 302802 39 31394492
Circulatory collapse 23.93 11.54 102 302711 19642 31374889
Neutropenic colitis 23.84 11.54 68 302745 2624 31391907
Low density lipoprotein increased 23.78 11.54 5 302808 4083 31390448
Mucocutaneous leishmaniasis 23.72 11.54 13 302800 73 31394458
Infectious pleural effusion 23.69 11.54 58 302755 2039 31392492
Ventricular hypertrophy 23.67 11.54 6 302807 4310 31390221
Pyopneumothorax 23.65 11.54 12 302801 56 31394475
Urticaria 23.59 11.54 718 302095 56799 31337732
Ventricular extrasystoles 23.58 11.54 44 302769 11098 31383433
C-reactive protein decreased 23.56 11.54 53 302760 1762 31392769
Abdominal pain upper 23.52 11.54 450 302363 63552 31330979
Inflammatory pain 23.50 11.54 17 302796 165 31394366
Osteoporosis 23.38 11.54 190 302623 11393 31383138
Diffuse large B-cell lymphoma recurrent 23.35 11.54 72 302741 2903 31391628
Symptom recurrence 23.35 11.54 26 302787 462 31394069
Subdural hygroma 23.33 11.54 21 302792 285 31394246
Anaphylactic shock 23.31 11.54 64 302749 14081 31380450
Pulmonary arteriopathy 23.30 11.54 13 302800 76 31394455
Granuloma 23.27 11.54 71 302742 2846 31391685
Physical disability 23.24 11.54 44 302769 1291 31393240
Polyuria 23.22 11.54 24 302789 7759 31386772
Asphyxia 23.21 11.54 13 302800 5738 31388793
Oesophageal stenosis 23.20 11.54 49 302764 1559 31392972
Dysarthria 23.11 11.54 195 302618 31822 31362709
Mycobacterium marinum infection 23.10 11.54 21 302792 289 31394242
Toxic leukoencephalopathy 23.04 11.54 21 302792 290 31394241
Human rhinovirus test positive 22.93 11.54 17 302796 172 31394359
Hepatitis B virus test positive 22.92 11.54 21 302792 292 31394239
Chronic graft versus host disease in intestine 22.86 11.54 19 302794 230 31394301
Dysphonia 22.79 11.54 110 302703 20481 31374050
Epstein-Barr virus associated lymphoma 22.64 11.54 30 302783 643 31393888
Antithrombin III decreased 22.64 11.54 21 302792 297 31394234
Osteosarcoma recurrent 22.60 11.54 9 302804 20 31394511
Iron deficiency anaemia 22.54 11.54 34 302779 9325 31385206
Nail psoriasis 22.54 11.54 12 302801 63 31394468
Prostatic specific antigen increased 22.50 11.54 61 302752 13477 31381054
Pneumonia cytomegaloviral 22.48 11.54 69 302744 2775 31391756
Granulomatosis with polyangiitis 22.47 11.54 39 302774 1068 31393463
Cheilitis 22.44 11.54 58 302755 2110 31392421
Ascites 22.43 11.54 267 302546 40746 31353785
JC virus infection 22.37 11.54 55 302758 1939 31392592
Meningitis aseptic 22.24 11.54 71 302742 2917 31391614
Lip swelling 22.16 11.54 60 302753 13263 31381268
Swollen joint count increased 22.14 11.54 16 302797 155 31394376
Acute monocytic leukaemia 22.06 11.54 22 302791 342 31394189
Blood glucose fluctuation 22.01 11.54 5 302808 3870 31390661
Dermatitis acneiform 21.92 11.54 14 302799 5753 31388778
Refusal of treatment by patient 21.90 11.54 9 302804 4752 31389779
Cytopenia 21.90 11.54 180 302633 10830 31383701
Enterovirus infection 21.90 11.54 31 302782 709 31393822
Herpes simplex encephalitis 21.87 11.54 21 302792 311 31394220
Intestinal ischaemia 21.85 11.54 21 302792 7024 31387507
Epstein-Barr virus test positive 21.84 11.54 26 302787 498 31394033
Synovectomy 21.81 11.54 12 302801 68 31394463
Neuroendocrine carcinoma of the skin 21.79 11.54 30 302783 668 31393863
Paraplegia 21.70 11.54 66 302747 2641 31391890
Refractoriness to platelet transfusion 21.67 11.54 12 302801 69 31394462
Gastrointestinal inflammation 21.66 11.54 74 302739 3151 31391380
Listeriosis 21.59 11.54 35 302778 905 31393626
Product complaint 21.56 11.54 13 302800 5511 31389020
Product administration error 21.55 11.54 74 302739 15173 31379358
Gastrooesophageal reflux disease 21.53 11.54 213 302600 33658 31360873
Juvenile melanoma benign 21.53 11.54 12 302801 70 31394461
Mycobacterium haemophilum infection 21.53 11.54 12 302801 70 31394461
Hidradenitis 21.48 11.54 37 302776 1007 31393524
Neutropenia 21.41 11.54 1587 301226 138777 31255754
Lung adenocarcinoma 21.41 11.54 92 302721 4370 31390161
Escherichia infection 21.30 11.54 131 302682 7173 31387358
Limb deformity 21.25 11.54 26 302787 513 31394018
Capnocytophaga infection 21.24 11.54 11 302802 54 31394477
Iritis 21.21 11.54 42 302771 1275 31393256
Lipodystrophy acquired 21.16 11.54 3 302810 3261 31391270
Extradural abscess 21.15 11.54 29 302784 643 31393888
Respiratory acidosis 21.15 11.54 9 302804 4653 31389878
Carcinoma in situ of skin 21.13 11.54 12 302801 73 31394458
Faecaloma 21.10 11.54 9 302804 4647 31389884
Prothrombin time prolonged 21.09 11.54 34 302779 9078 31385453
Joint warmth 21.05 11.54 20 302793 292 31394239
Injection site papule 21.00 11.54 20 302793 293 31394238
Steatohepatitis 21.00 11.54 20 302793 293 31394238
Injection site erythema 20.99 11.54 221 302592 14241 31380290
Tuberculous pleurisy 20.89 11.54 22 302791 366 31394165
Hodgkin's disease 20.87 11.54 33 302780 835 31393696
Colorectal cancer 20.85 11.54 10 302803 4819 31389712
Skin dystrophy 20.84 11.54 7 302806 7 31394524
Angioimmunoblastic T-cell lymphoma stage IV 20.84 11.54 7 302806 7 31394524
Muscle haemorrhage 20.78 11.54 4 302809 3476 31391055
Coma scale abnormal 20.76 11.54 5 302808 3718 31390813
Defaecation urgency 20.73 11.54 54 302759 1974 31392557
Blood magnesium decreased 20.71 11.54 15 302798 5771 31388760
Cerebral infarction 20.70 11.54 154 302659 25823 31368708
Hypogammaglobulinaemia 20.69 11.54 121 302692 6506 31388025
Rheumatoid vasculitis 20.68 11.54 18 302795 233 31394298
Muscle swelling 20.63 11.54 21 302792 335 31394196
Anal inflammation 20.61 11.54 22 302791 372 31394159
Acute pulmonary histoplasmosis 20.54 11.54 15 302798 148 31394383
Pain of skin 20.51 11.54 86 302727 4040 31390491
Meningitis listeria 20.51 11.54 23 302790 412 31394119
Vasculitis 20.48 11.54 146 302667 8404 31386127
Bacterial infection 20.43 11.54 211 302602 13528 31381003
Second primary malignancy 20.43 11.54 126 302687 6906 31387625
International normalised ratio decreased 20.32 11.54 8 302805 4335 31390196
Myocarditis 20.24 11.54 53 302760 11847 31382684
Atrioventricular block 20.24 11.54 24 302789 7291 31387240
Neonatal respiratory distress syndrome 20.18 11.54 6 302807 3879 31390652
Legionella infection 20.15 11.54 24 302789 460 31394071
Haemorrhagic stroke 20.13 11.54 17 302796 6053 31388478
Medication error 20.11 11.54 131 302682 22641 31371890
Body temperature decreased 20.07 11.54 186 302627 11584 31382947
Pharyngeal inflammation 20.05 11.54 20 302793 311 31394220
Epstein-Barr virus antigen positive 20.03 11.54 9 302804 30 31394501
Tongue disorder 20.03 11.54 98 302715 4919 31389612
Episcleritis 19.95 11.54 14 302799 129 31394402
Hyperuricaemia 19.95 11.54 25 302788 7413 31387118
Morphoea 19.89 11.54 15 302798 156 31394375
Tinea versicolour 19.86 11.54 19 302794 280 31394251
Endocarditis bacterial 19.85 11.54 33 302780 872 31393659
Coordination abnormal 19.84 11.54 24 302789 7227 31387304
Blood pressure diastolic abnormal 19.83 11.54 83 302730 3896 31390635
Thymus enlargement 19.82 11.54 10 302803 46 31394485
Acute lymphocytic leukaemia refractory 19.81 11.54 13 302800 106 31394425
Hepatic function abnormal 19.79 11.54 525 302288 40697 31353834
Enzyme abnormality 19.77 11.54 16 302797 186 31394345
Bone marrow transplant rejection 19.77 11.54 16 302797 186 31394345
Encephalitis 19.73 11.54 122 302691 6693 31387838
Muscle twitching 19.72 11.54 30 302783 8200 31386331
Macule 19.63 11.54 37 302776 1082 31393449
Swelling face 19.43 11.54 122 302691 21268 31373263
Pityriasis rubra pilaris 19.42 11.54 13 302800 110 31394421
Spinal cord disorder 19.38 11.54 30 302783 745 31393786
Burkitt's lymphoma 19.34 11.54 14 302799 136 31394395
Neutrophil count decreased 19.33 11.54 319 302494 46075 31348456
Musculoskeletal disorder 19.33 11.54 107 302706 5637 31388894
Lennox-Gastaut syndrome 19.32 11.54 10 302803 49 31394482
Infectious thyroiditis 19.32 11.54 12 302801 88 31394443
Escherichia sepsis 19.29 11.54 85 302728 4082 31390449
Immune recovery uveitis 19.12 11.54 7 302806 11 31394520
Transplant rejection 19.11 11.54 40 302773 9668 31384863
Shoulder arthroplasty 19.10 11.54 23 302790 446 31394085
Meningitis staphylococcal 19.10 11.54 11 302802 69 31394462
Empyema 19.06 11.54 67 302746 2894 31391637
Face oedema 19.06 11.54 46 302767 10570 31383961
Mesenteritis 19.00 11.54 9 302804 35 31394496
Infusion related reaction 18.94 11.54 597 302216 47458 31347073
Blood pressure systolic increased 18.94 11.54 276 302537 19194 31375337
Cutaneous symptom 18.94 11.54 18 302795 263 31394268
Cardiac murmur 18.91 11.54 22 302791 6740 31387791
Trichosporon infection 18.88 11.54 28 302785 669 31393862
Psychomotor retardation 18.87 11.54 4 302809 3248 31391283
Sinusitis fungal 18.86 11.54 25 302788 536 31393995
Prescribed overdose 18.84 11.54 37 302776 9155 31385376
Acute coronary syndrome 18.81 11.54 61 302752 12728 31381803
Intestinal stenosis 18.78 11.54 51 302762 1912 31392619
Urine output decreased 18.74 11.54 39 302774 9447 31385084
Staphylococcal bacteraemia 18.73 11.54 130 302683 7418 31387113
Nephrolithiasis 18.70 11.54 366 302447 26973 31367558
Ketoacidosis 18.65 11.54 7 302806 3905 31390626
Meningitis chemical 18.60 11.54 11 302802 73 31394458
Ligament calcification 18.58 11.54 16 302797 204 31394327
Sleep disorder due to a general medical condition 18.57 11.54 7 302806 3895 31390636
Cystitis viral 18.48 11.54 24 302789 504 31394027
Pneumocystis jirovecii infection 18.47 11.54 45 302768 1577 31392954
Gout 18.46 11.54 100 302713 18074 31376457
Varicella 18.39 11.54 44 302769 1524 31393007
Thirst 18.37 11.54 22 302791 6654 31387877
Heavy chain disease 18.30 11.54 5 302808 0 31394531
B precursor type acute leukaemia 18.29 11.54 17 302796 241 31394290
Blood phosphorus increased 18.28 11.54 10 302803 4472 31390059
Cerebral toxoplasmosis 18.23 11.54 44 302769 1533 31392998
Blood testosterone decreased 18.22 11.54 9 302804 4264 31390267
Oral surgery 18.18 11.54 25 302788 556 31393975
Cushingoid 18.15 11.54 59 302754 2448 31392083
Hypothyroidism 18.09 11.54 99 302714 17848 31376683
Electrocardiogram ST segment elevation 18.08 11.54 11 302802 4640 31389891
Inflammatory myofibroblastic tumour 17.99 11.54 13 302800 126 31394405
Mucosal disorder 17.94 11.54 43 302770 1491 31393040
Electrocardiogram QRS complex prolonged 17.89 11.54 9 302804 4220 31390311
Myocardial ischaemia 17.89 11.54 90 302723 16577 31377954
Leukodystrophy 17.86 11.54 6 302807 6 31394525
Herpes simplex 17.85 11.54 98 302715 5147 31389384
Leishmaniasis 17.81 11.54 19 302794 321 31394210
Pseudomonal sepsis 17.79 11.54 69 302744 3127 31391404
Cytomegalovirus hepatitis 17.77 11.54 21 302792 399 31394132
Body temperature fluctuation 17.75 11.54 44 302769 1559 31392972
Monoclonal B-cell lymphocytosis 17.73 11.54 8 302805 27 31394504
Mucosal necrosis 17.72 11.54 10 302803 60 31394471
Cystitis escherichia 17.71 11.54 14 302799 157 31394374
Adenoviral hepatitis 17.68 11.54 23 302790 484 31394047
Drug level below therapeutic 17.64 11.54 95 302718 4953 31389578
Somnambulism 17.63 11.54 3 302810 2849 31391682
International normalised ratio abnormal 17.63 11.54 4 302809 3098 31391433
Cerebral thrombosis 17.57 11.54 32 302781 911 31393620
Mediastinal mass 17.50 11.54 14 302799 160 31394371
Diarrhoea haemorrhagic 17.48 11.54 109 302704 5997 31388534
Splenic infection fungal 17.46 11.54 11 302802 83 31394448
Infective tenosynovitis 17.46 11.54 10 302803 62 31394469
Stem cell transplant 17.43 11.54 51 302762 1997 31392534
Micrognathia 17.40 11.54 18 302795 293 31394238
Dyspnoea at rest 17.37 11.54 6 302807 3525 31391006
Bronchopulmonary aspergillosis 17.34 11.54 203 302610 13431 31381100
Taste disorder 17.34 11.54 17 302796 5633 31388898
Gallbladder oedema 17.27 11.54 16 302797 226 31394305
Pharyngitis 17.25 11.54 125 302688 7233 31387298
Pericarditis tuberculous 17.25 11.54 11 302802 85 31394446
Bronchiolitis obliterans syndrome 17.22 11.54 14 302799 164 31394367
Urinary incontinence 17.21 11.54 96 302717 17224 31377307
Glottis carcinoma 17.16 11.54 7 302806 17 31394514
Bursitis infective staphylococcal 17.16 11.54 7 302806 17 31394514
Haemodynamic instability 17.16 11.54 35 302778 8540 31385991
Electrolyte imbalance 17.14 11.54 59 302754 12089 31382442
Post procedural infection 17.10 11.54 87 302726 4436 31390095
Ventricular arrhythmia 17.10 11.54 13 302800 4878 31389653
Antisynthetase syndrome 17.08 11.54 10 302803 65 31394466
Squamous cell carcinoma of the tongue 17.06 11.54 17 302796 264 31394267
Mental disorder 17.05 11.54 71 302742 13763 31380768
Arthroscopy 17.04 11.54 11 302802 87 31394444
Erythema multiforme 16.97 11.54 32 302781 8039 31386492
Dysplastic naevus syndrome 16.96 11.54 6 302807 8 31394523
Iris adhesions 16.93 11.54 16 302797 232 31394299
Silicosis 16.88 11.54 7 302806 18 31394513
C-reactive protein 16.88 11.54 12 302801 113 31394418
Osteomyelitis 16.88 11.54 214 302599 14429 31380102
Alveolitis 16.85 11.54 43 302770 1552 31392979
Lung neoplasm 16.83 11.54 85 302728 4321 31390210
Stenotrophomonas infection 16.83 11.54 48 302765 1852 31392679
Sudden cardiac death 16.73 11.54 6 302807 3443 31391088
Self-consciousness 16.71 11.54 8 302805 32 31394499
Phototherapy 16.71 11.54 8 302805 32 31394499
Precursor T-lymphoblastic lymphoma/leukaemia 16.71 11.54 10 302803 68 31394463
Joint abscess 16.71 11.54 12 302801 115 31394416
Ophthalmic herpes zoster 16.70 11.54 30 302783 845 31393686
Hyperthermia 16.68 11.54 45 302768 9959 31384572
Hypersensitivity pneumonitis 16.67 11.54 40 302773 1388 31393143
Cerebrosclerosis 16.62 11.54 7 302806 19 31394512
Thrombosis in device 16.60 11.54 5 302808 3205 31391326
Nocturia 16.59 11.54 40 302773 9195 31385336
Catatonia 16.57 11.54 13 302800 4801 31389730
Herpes virus infection 16.53 11.54 59 302754 2568 31391963
Bundle branch block left 16.48 11.54 17 302796 5501 31389030
Adult T-cell lymphoma/leukaemia 16.42 11.54 17 302796 277 31394254
Toxic epidermal necrolysis 16.40 11.54 114 302699 19410 31375121
Ischaemic stroke 16.36 11.54 95 302718 16876 31377655
Hepatic failure 16.35 11.54 217 302596 32485 31362046
Lymphopenia 16.34 11.54 209 302604 14120 31380411
Fine motor skill dysfunction 16.26 11.54 44 302769 1646 31392885
Central nervous system infection 16.21 11.54 23 302790 527 31394004
Secondary amyloidosis 16.14 11.54 10 302803 73 31394458
Knee operation 16.13 11.54 44 302769 1654 31392877
Cytokine release syndrome 16.13 11.54 93 302720 16549 31377982
Alcohol abuse 16.12 11.54 12 302801 4552 31389979
Stomatitis haemorrhagic 16.08 11.54 9 302804 53 31394478
Protein urine present 16.05 11.54 14 302799 4906 31389625
Temporal lobe epilepsy 16.04 11.54 14 302799 182 31394349
White matter lesion 16.02 11.54 26 302787 673 31393858
Large intestinal stenosis 16.00 11.54 40 302773 1425 31393106
Tooth abscess 16.00 11.54 95 302718 5137 31389394
Mood swings 15.99 11.54 29 302784 7395 31387136
Abscess intestinal 15.96 11.54 41 302772 1486 31393045
Hepatic candidiasis 15.95 11.54 9 302804 54 31394477
Autoimmune lymphoproliferative syndrome 15.94 11.54 13 302800 153 31394378
Lymphadenitis 15.93 11.54 44 302769 1666 31392865
Meningoencephalitis herpetic 15.92 11.54 28 302785 775 31393756
Toxoplasmosis 15.87 11.54 37 302776 1260 31393271
Steroid diabetes 15.87 11.54 47 302766 1853 31392678
Sinusitis 15.83 11.54 461 302352 36235 31358296
Acute pulmonary oedema 15.82 11.54 27 302786 7049 31387482
Visual acuity reduced 15.82 11.54 84 302729 15259 31379272
Infective myositis 15.81 11.54 9 302804 55 31394476
Cauda equina syndrome 15.78 11.54 21 302792 452 31394079
Pulmonary congestion 15.78 11.54 67 302746 12916 31381615
Scab 15.76 11.54 80 302733 4075 31390456
Demyelinating polyneuropathy 15.75 11.54 35 302778 1154 31393377
Anaplastic large cell lymphoma T- and null-cell types 15.74 11.54 12 302801 127 31394404
Azotaemia 15.73 11.54 13 302800 4679 31389852
Iridocyclitis 15.73 11.54 41 302772 1499 31393032
Ammonia increased 15.71 11.54 10 302803 4117 31390414
Tonsillar ulcer 15.67 11.54 13 302800 157 31394374
Bladder neoplasm 15.66 11.54 37 302776 1271 31393260
Chronic actinic dermatitis 15.66 11.54 7 302806 23 31394508
Cholangitis 15.64 11.54 33 302780 7953 31386578
Remission not achieved 15.62 11.54 11 302802 102 31394429
Meningitis enterococcal 15.60 11.54 10 302803 78 31394453
Exostosis 15.58 11.54 76 302737 3810 31390721
Panniculitis 15.55 11.54 45 302768 1751 31392780
Neoplasm recurrence 15.53 11.54 50 302763 2064 31392467
Systemic candida 15.52 11.54 66 302747 3120 31391411
Pemphigoid 15.52 11.54 35 302778 8236 31386295
Q fever 15.44 11.54 12 302801 131 31394400
Pneumonia adenoviral 15.44 11.54 18 302795 337 31394194
Adactyly 15.43 11.54 9 302804 58 31394473
Cardiomegaly 15.42 11.54 78 302735 14347 31380184
Crohn's disease 15.39 11.54 79 302734 4042 31390489
Extranodal marginal zone B-cell lymphoma (MALT type) 15.38 11.54 14 302799 193 31394338
Cardiac failure acute 15.37 11.54 45 302768 9696 31384835
Tender joint count increased 15.36 11.54 11 302802 105 31394426
Thyroid cancer 15.31 11.54 42 302771 1584 31392947
Eye infection toxoplasmal 15.21 11.54 15 302798 230 31394301
West Nile viral infection 15.19 11.54 25 302788 655 31393876
Chills 15.19 11.54 567 302246 73583 31320948
Glomerular filtration rate decreased 15.19 11.54 60 302753 11805 31382726
Malignant melanoma stage I 15.10 11.54 10 302803 83 31394448
Faecal calprotectin abnormal 15.09 11.54 14 302799 198 31394333
Multiple sclerosis 15.09 11.54 34 302779 8003 31386528
Meningitis 15.08 11.54 85 302728 4509 31390022
Gastrointestinal wall thickening 15.02 11.54 38 302775 1364 31393167
Stupor 15.02 11.54 4 302809 2780 31391751
Blood cholesterol increased 15.01 11.54 97 302716 16796 31377735
Chronic graft versus host disease in liver 14.95 11.54 18 302795 349 31394182
Bursa disorder 14.92 11.54 14 302799 201 31394330
Viral mutation identified 14.90 11.54 4 302809 2765 31391766
Bladder neck operation 14.88 11.54 5 302808 5 31394526
Joint space narrowing 14.86 11.54 11 302802 111 31394420
Osteomyelitis salmonella 14.82 11.54 7 302806 27 31394504
Micturition urgency 14.79 11.54 20 302793 5740 31388791
Palmoplantar pustulosis 14.78 11.54 11 302802 112 31394419
Renal cell carcinoma 14.78 11.54 99 302714 5583 31388948
Amyloidosis 14.75 11.54 51 302762 2185 31392346
Eructation 14.75 11.54 11 302802 4168 31390363
Small fibre neuropathy 14.73 11.54 8 302805 44 31394487
Vascular access complication 14.71 11.54 17 302796 315 31394216
Subcutaneous abscess 14.70 11.54 70 302743 3474 31391057
Oral toxicity 14.64 11.54 4 302809 0 31394531
Fear-related avoidance of activities 14.64 11.54 4 302809 0 31394531
Behaviour disorder 14.63 11.54 12 302801 4335 31390196
Dialysis 14.63 11.54 52 302761 10551 31383980
Injection site reaction 14.61 11.54 173 302640 11478 31383053
Cyanosis 14.61 11.54 60 302753 11675 31382856
Nail pitting 14.51 11.54 15 302798 244 31394287
Nephrogenic systemic fibrosis 14.49 11.54 10 302803 3945 31390586
Eye irritation 14.46 11.54 25 302788 6493 31388038
Cutaneous tuberculosis 14.44 11.54 10 302803 90 31394441
Fusarium infection 14.42 11.54 32 302781 1054 31393477
Cataract 14.40 11.54 313 302500 23494 31371037
Blood culture positive 14.39 11.54 84 302729 4514 31390017
Hepatitis E 14.38 11.54 45 302768 1829 31392702
Hypersomnia 14.38 11.54 56 302757 11063 31383468
Nasal cavity cancer 14.35 11.54 13 302800 178 31394353
Myeloid leukaemia 14.34 11.54 18 302795 365 31394166
Purulent pericarditis 14.32 11.54 6 302807 16 31394515
Inadequate analgesia 14.28 11.54 4 302809 2689 31391842
Stress ulcer 14.27 11.54 9 302804 68 31394463
Enterovesical fistula 14.27 11.54 25 302788 690 31393841
Respiratory failure 14.26 11.54 808 302005 100641 31293890
Communication disorder 14.24 11.54 3 302810 2447 31392084
Actinomycosis 14.23 11.54 18 302795 368 31394163
Systemic lupus erythematosus 14.20 11.54 62 302751 2966 31391565
Crystal nephropathy 14.19 11.54 18 302795 369 31394162
Haematopoietic neoplasm 14.18 11.54 8 302805 48 31394483
Muscle abscess 14.15 11.54 21 302792 502 31394029
Septic shock 14.10 11.54 770 302043 65388 31329143
Encephalitis viral 14.09 11.54 33 302780 1127 31393404
Hepatitis C 14.09 11.54 53 302760 10577 31383954
Ossicle disorder 14.08 11.54 7 302806 31 31394500
Arteriosclerosis 14.07 11.54 54 302759 10713 31383818
Vitreous floaters 14.05 11.54 7 302806 3300 31391231
Salivary gland cancer 14.04 11.54 16 302797 292 31394239
Cartilage injury 14.03 11.54 21 302792 506 31394025
Strongyloidiasis 13.96 11.54 55 302758 2511 31392020
Blood urine present 13.89 11.54 50 302763 10107 31384424
Splenic lesion 13.87 11.54 11 302802 124 31394407
Infective aneurysm 13.85 11.54 21 302792 512 31394019
Coronary arterial stent insertion 13.84 11.54 11 302802 4037 31390494
Anaemia megaloblastic 13.84 11.54 13 302800 187 31394344
Polychondritis 13.82 11.54 14 302799 222 31394309
Loss of libido 13.79 11.54 3 302810 2392 31392139
Euphoric mood 13.76 11.54 16 302797 4904 31389627
B-cell lymphoma stage IV 13.76 11.54 9 302804 73 31394458
Diffuse large B-cell lymphoma stage III 13.76 11.54 9 302804 73 31394458
Mydriasis 13.75 11.54 26 302787 6526 31388005
Cerebral haematoma 13.75 11.54 13 302800 4382 31390149
Activated partial thromboplastin time prolonged 13.71 11.54 37 302776 8188 31386343
Cardiomyopathy 13.65 11.54 88 302725 15245 31379286
Restless legs syndrome 13.61 11.54 34 302779 7722 31386809
Ear canal stenosis 13.60 11.54 5 302808 8 31394523
Scrotal cancer 13.60 11.54 5 302808 8 31394523
Radiation myelopathy 13.60 11.54 5 302808 8 31394523
Encephalitis Japanese B 13.58 11.54 6 302807 19 31394512
Impaired gastric emptying 13.58 11.54 7 302806 3237 31391294
Cerebral fungal infection 13.57 11.54 14 302799 227 31394304
Anal squamous cell carcinoma 13.56 11.54 9 302804 75 31394456
Purulent discharge 13.55 11.54 56 302757 2614 31391917
Hypotonia 13.53 11.54 30 302783 7103 31387428
Ileus 13.53 11.54 87 302726 15082 31379449
Desmoid tumour 13.52 11.54 11 302802 129 31394402
Keratitis 13.49 11.54 35 302778 1276 31393255
Low birth weight baby 13.48 11.54 29 302784 6941 31387590
Chimerism 13.48 11.54 14 302799 229 31394302
Increased appetite 13.47 11.54 25 302788 6319 31388212
Sepsis 13.46 11.54 1653 301160 150276 31244255
Pericardial haemorrhage 13.41 11.54 6 302807 3011 31391520
Blood glucose abnormal 13.39 11.54 19 302794 5344 31389187
Scleritis 13.39 11.54 20 302793 481 31394050
Post lumbar puncture syndrome 13.35 11.54 13 302800 196 31394335
Cardiotoxicity 13.32 11.54 88 302725 4939 31389592
Folate deficiency 13.32 11.54 33 302780 1169 31393362
Hypercapnia 13.32 11.54 11 302802 3960 31390571
Mixed liver injury 13.31 11.54 3 302810 2334 31392197
Fistula 13.31 11.54 97 302716 5624 31388907
Skin bacterial infection 13.27 11.54 9 302804 78 31394453
Bradykinesia 13.27 11.54 9 302804 3583 31390948
Hemiparesis 13.27 11.54 208 302605 14686 31379845
Steroid dependence 13.27 11.54 20 302793 485 31394046
CSF myelin basic protein increased 13.24 11.54 5 302808 9 31394522
Musculoskeletal deformity 13.24 11.54 5 302808 9 31394522
Adenoviral haemorrhagic cystitis 13.23 11.54 18 302795 396 31394135
Gynaecomastia 13.23 11.54 44 302769 9110 31385421
Small cell lung cancer metastatic 13.22 11.54 16 302797 312 31394219
Mycobacterium avium complex infection 13.20 11.54 52 302761 2374 31392157
Bronchoalveolar lavage abnormal 13.18 11.54 9 302804 79 31394452
Abscess bacterial 13.15 11.54 12 302801 166 31394365
Dry skin 13.13 11.54 168 302645 25313 31369218
Subarachnoid haemorrhage 13.11 11.54 52 302761 10219 31384312
CNS ventriculitis 13.10 11.54 14 302799 237 31394294
Lower gastrointestinal haemorrhage 13.09 11.54 41 302772 8648 31385883
Sinus tachycardia 13.09 11.54 93 302720 15756 31378775
Pancreatic neoplasm 13.06 11.54 27 302786 846 31393685
Visual impairment 13.05 11.54 215 302598 31064 31363467
Tonsillar disorder 13.05 11.54 11 302802 136 31394395
Transfusion 13.02 11.54 34 302779 7606 31386925
Cancer pain 13.00 11.54 4 302809 2529 31392002
Diabetes mellitus inadequate control 13.00 11.54 70 302743 12671 31381860
Intestinal atresia 12.99 11.54 9 302804 81 31394450
Hepatosplenic candidiasis 12.99 11.54 13 302800 203 31394328
Pneumonitis chemical 12.98 11.54 11 302802 137 31394394
Post inflammatory pigmentation change 12.96 11.54 14 302799 240 31394291
Testicular seminoma (pure) 12.96 11.54 8 302805 58 31394473
SAPHO syndrome 12.96 11.54 10 302803 108 31394423
Gastric ulcer haemorrhage 12.94 11.54 18 302795 5105 31389426
Abscess sterile 12.93 11.54 6 302807 22 31394509
Hepatitis acute 12.91 11.54 28 302785 6681 31387850
Solar urticaria 12.91 11.54 5 302808 10 31394521
Meningitis noninfective 12.91 11.54 5 302808 10 31394521
Encephalitis brain stem 12.91 11.54 9 302804 82 31394449
Superior mesenteric artery syndrome 12.91 11.54 9 302804 82 31394449
Therapy change 12.88 11.54 5 302808 2733 31391798
Skin injury 12.88 11.54 42 302771 1745 31392786
Injection site rash 12.85 11.54 70 302743 3666 31390865
Furuncle 12.84 11.54 61 302752 3025 31391506
Diffuse idiopathic skeletal hyperostosis 12.82 11.54 7 302806 39 31394492
Lower respiratory tract infection 12.81 11.54 357 302456 27880 31366651
Graft versus host disease in lung 12.80 11.54 20 302793 501 31394030
Mitral valve incompetence 12.76 11.54 80 302733 13953 31380578
Oesophageal squamous cell carcinoma 12.74 11.54 17 302796 367 31394164
Joint noise 12.74 11.54 21 302792 551 31393980
Double stranded DNA antibody 12.73 11.54 6 302807 23 31394508
Aplasia pure red cell 12.73 11.54 22 302791 5715 31388816
Haemorrhage intracranial 12.72 11.54 88 302725 15000 31379531
Psychomotor skills impaired 12.72 11.54 7 302806 3120 31391411
Blood pressure diastolic increased 12.69 11.54 77 302736 4196 31390335
Small cell lung cancer 12.68 11.54 43 302770 1824 31392707
Body height decreased 12.68 11.54 9 302804 3498 31391033
Hallucinations, mixed 12.67 11.54 4 302809 2488 31392043
Quadriplegia 12.65 11.54 39 302774 1572 31392959
Total lung capacity decreased 12.61 11.54 22 302791 605 31393926
Immune system disorder 12.61 11.54 80 302733 4428 31390103
Exposure to communicable disease 12.60 11.54 11 302802 143 31394388
Myoglobin blood increased 12.55 11.54 4 302809 2473 31392058
Spinal cord abscess 12.55 11.54 13 302800 212 31394319
Meningitis viral 12.53 11.54 26 302787 817 31393714
Nervousness 12.50 11.54 64 302749 11736 31382795
Blood chloride decreased 12.49 11.54 10 302803 3656 31390875
Skin infection 12.49 11.54 110 302703 6753 31387778
Ocular hypertension 12.45 11.54 25 302788 767 31393764
Heart rate decreased 12.44 11.54 356 302457 27910 31366621
Hot flush 12.44 11.54 97 302716 16099 31378432
Nail dystrophy 12.43 11.54 12 302801 179 31394352
Xanthogranuloma 12.42 11.54 8 302805 63 31394468
Joint injury 12.42 11.54 122 302691 7719 31386812
Suspected product quality issue 12.42 11.54 11 302802 146 31394385
Small for dates baby 12.41 11.54 10 302803 3645 31390886
Personality change due to a general medical condition 12.40 11.54 7 302806 42 31394489
Accidental exposure to product 12.38 11.54 62 302751 11433 31383098
Immobile 12.37 11.54 50 302763 2310 31392221
Compartment syndrome 12.37 11.54 5 302808 2666 31391865
Tonsillitis 12.36 11.54 46 302767 2044 31392487
Anuria 12.33 11.54 50 302763 9764 31384767
Radial nerve palsy 12.32 11.54 8 302805 64 31394467
Dermatitis psoriasiform 12.31 11.54 32 302781 1168 31393363
Mucosal infection 12.31 11.54 13 302800 217 31394314
Wrist surgery 12.30 11.54 11 302802 148 31394383
Investigation abnormal 12.27 11.54 19 302794 472 31394059
Polyarteritis nodosa 12.26 11.54 14 302799 256 31394275
Prostate infection 12.23 11.54 26 302787 831 31393700
Multiple allergies 12.22 11.54 4 302809 2431 31392100
Thyroid gland abscess 12.22 11.54 8 302805 65 31394466
Left ventricular hypertrophy 12.21 11.54 33 302780 7299 31387232
BK virus infection 12.20 11.54 87 302726 5008 31389523
HLA-B*27 positive 12.17 11.54 6 302807 26 31394505
Palindromic rheumatism 12.17 11.54 12 302801 184 31394347
Hepatitis B reactivation 12.15 11.54 66 302747 3452 31391079
Vitreous haemorrhage 12.15 11.54 3 302810 2193 31392338
Intestinal fibrosis 12.14 11.54 9 302804 91 31394440
Proteinuria 12.14 11.54 102 302711 16661 31377870
Medulloblastoma recurrent 12.12 11.54 8 302805 66 31394465
Herpes zoster oticus 12.10 11.54 10 302803 120 31394411
Acanthosis 12.10 11.54 10 302803 120 31394411
Nasal septum perforation 12.10 11.54 10 302803 120 31394411
Blood beta-D-glucan increased 12.10 11.54 17 302796 386 31394145
Laboratory test abnormal 12.09 11.54 118 302695 18696 31375835
Dermatomyositis 12.06 11.54 32 302781 1183 31393348
Product residue present 12.05 11.54 5 302808 2625 31391906
Enuresis 12.05 11.54 3 302810 2181 31392350
N-terminal prohormone brain natriuretic peptide increased 12.05 11.54 3 302810 2181 31392350
Infected dermal cyst 12.04 11.54 25 302788 786 31393745
Drainage 12.02 11.54 5 302808 13 31394518
Feeling jittery 12.02 11.54 11 302802 3766 31390765
Hepatitis infectious mononucleosis 12.02 11.54 7 302806 45 31394486
Wrong product administered 12.01 11.54 18 302795 4950 31389581
Spinal cord oedema 12.01 11.54 12 302801 187 31394344
Diverticular perforation 12.01 11.54 61 302752 3108 31391423
Scedosporium infection 11.96 11.54 26 302787 844 31393687
Respiration abnormal 11.95 11.54 6 302807 2816 31391715
Intracranial pressure increased 11.94 11.54 67 302746 3548 31390983
Attention deficit hyperactivity disorder 11.93 11.54 4 302809 2394 31392137
Haemangioma of liver 11.93 11.54 19 302794 484 31394047
Pseudolymphoma 11.91 11.54 20 302793 533 31393998
Bacterial myositis 11.91 11.54 4 302809 4 31394527
Intervertebral disc annular tear 11.91 11.54 4 302809 4 31394527
Yolk sac tumour site unspecified 11.91 11.54 4 302809 4 31394527
Rash pruritic 11.91 11.54 159 302654 23779 31370752
Extrapulmonary tuberculosis 11.90 11.54 9 302804 94 31394437
Cryptococcal fungaemia 11.90 11.54 9 302804 94 31394437
Elbow operation 11.90 11.54 10 302803 123 31394408
Pneumoconiosis 11.90 11.54 13 302800 226 31394305
Atypical mycobacterial infection 11.89 11.54 24 302789 739 31393792
Social avoidant behaviour 11.89 11.54 7 302806 3006 31391525
Blood pressure diastolic decreased 11.89 11.54 123 302690 7890 31386641
Myositis 11.85 11.54 60 302753 11034 31383497
Ankle operation 11.85 11.54 13 302800 227 31394304
Cyst rupture 11.83 11.54 8 302805 69 31394462
Tendon disorder 11.81 11.54 52 302761 2496 31392035
Antinuclear antibody positive 11.81 11.54 34 302779 1319 31393212
Muscle oedema 11.78 11.54 11 302802 157 31394374
Total cholesterol/HDL ratio decreased 11.77 11.54 7 302806 47 31394484
Echinococciasis 11.76 11.54 5 302808 14 31394517
VIth nerve paralysis 11.74 11.54 24 302789 746 31393785
Viral vasculitis 11.73 11.54 8 302805 70 31394461
Injection site warmth 11.72 11.54 42 302771 1832 31392699
Throat tightness 11.69 11.54 36 302777 7633 31386898
Vascular stent thrombosis 11.67 11.54 6 302807 2779 31391752
Cavernous sinus thrombosis 11.67 11.54 11 302802 159 31394372
Inflammatory pseudotumour 11.66 11.54 6 302807 29 31394502
Nail injury 11.66 11.54 6 302807 29 31394502
Brain sarcoma 11.65 11.54 7 302806 48 31394483
Pulmonary air leakage 11.64 11.54 10 302803 127 31394404
Anal fissure 11.62 11.54 64 302749 3365 31391166
Alcohol use 11.61 11.54 8 302805 3159 31391372
Poikiloderma 11.61 11.54 11 302802 160 31394371
Nocardiosis 11.58 11.54 65 302748 3442 31391089
Ulcer 11.58 11.54 120 302693 7701 31386830
Shoulder operation 11.55 11.54 27 302786 921 31393610

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 12620.43 11.57 33778 906420 905974 69082272
Rheumatoid arthritis 7941.75 11.57 14008 926190 277797 69710449
Drug intolerance 4959.87 11.57 9896 930302 215791 69772455
Joint swelling 3325.28 11.57 9075 931123 244136 69744110
Treatment failure 3141.01 11.57 6303 933895 137839 69850407
Arthralgia 2918.83 11.57 13788 926410 489602 69498644
Death 2799.35 11.57 1649 938549 508412 69479834
Completed suicide 2701.12 11.57 65 940133 227070 69761176
Drug hypersensitivity 2590.14 11.57 8505 931693 253954 69734292
Therapeutic product effect incomplete 2137.44 11.57 4833 935365 115049 69873197
Synovitis 2080.11 11.57 5005 935193 124223 69864023
Musculoskeletal stiffness 1715.83 11.57 5070 935128 142690 69845556
Contraindicated product administered 1705.45 11.57 4766 935432 129846 69858400
Drug abuse 1574.67 11.57 94 940104 147162 69841084
Therapeutic product effect decreased 1554.74 11.57 4795 935403 138223 69850023
Lymphoproliferative disorder 1527.90 11.57 926 939272 4403 69983843
Hypotension 1341.88 11.57 2054 938144 402327 69585919
Arthropathy 1320.69 11.57 4684 935514 145373 69842873
Psoriasis 1284.71 11.57 3524 936674 94909 69893337
Psoriatic arthropathy 1280.35 11.57 2723 937475 62048 69926198
Acute kidney injury 1259.01 11.57 2766 937432 471858 69516388
Constipation 1103.10 11.57 1032 939166 251406 69736840
Dyspnoea 1086.62 11.57 5894 934304 764166 69224080
Arthritis 1048.40 11.57 3268 936930 94712 69893534
Pain 1021.37 11.57 12765 927433 616051 69372195
Liver function test increased 959.92 11.57 1659 938539 32188 69956058
Intentional overdose 938.52 11.57 104 940094 98331 69889915
Hyponatraemia 916.73 11.57 489 939709 159598 69828648
Dehydration 916.33 11.57 987 939211 225155 69763091
Cardiac arrest 914.14 11.57 489 939709 159345 69828901
Hyperkalaemia 907.43 11.57 159 940039 106432 69881814
Bradycardia 901.11 11.57 266 939932 124349 69863897
Alopecia 818.02 11.57 4959 935239 193531 69794715
Rhabdomyolysis 816.99 11.57 142 940056 95618 69892628
C-reactive protein abnormal 812.55 11.57 1665 938533 36914 69951332
Somnolence 775.53 11.57 1033 939165 214573 69773673
Anaemia 773.67 11.57 2748 937450 400675 69587571
Cardiac failure congestive 723.80 11.57 450 939748 135007 69853239
Electrocardiogram QT prolonged 720.95 11.57 120 940078 83397 69904849
Drug interaction 718.87 11.57 2617 937581 378824 69609422
Overdose 717.77 11.57 714 939484 169031 69819215
Acute graft versus host disease 713.91 11.57 752 939446 8810 69979436
Cardio-respiratory arrest 706.08 11.57 227 939971 100450 69887796
Pancytopenia 705.60 11.57 3903 936295 147204 69841042
Red blood cell sedimentation rate increased 701.33 11.57 1570 938628 37072 69951174
Mucosal inflammation 694.35 11.57 2229 937969 65621 69922625
Red blood cell sedimentation rate abnormal 692.91 11.57 1053 939145 18250 69969996
C-reactive protein increased 690.06 11.57 3100 937098 107417 69880829
Hepatic enzyme increased 670.09 11.57 3959 936239 153031 69835215
Dizziness 668.95 11.57 3523 936675 460618 69527628
Mouth ulceration 662.37 11.57 1430 938768 32919 69955327
International normalised ratio increased 660.22 11.57 133 940065 80593 69907653
Toxicity to various agents 657.28 11.57 2720 937478 379452 69608794
Syncope 632.12 11.57 759 939439 164950 69823296
Swelling 626.14 11.57 4463 935735 184076 69804170
Pain in extremity 615.74 11.57 6853 933345 321229 69667017
Infection 612.71 11.57 4835 935363 205950 69782296
Injection site pain 604.11 11.57 3119 937079 114500 69873746
Hypoglycaemia 598.85 11.57 250 939948 94114 69894132
Confusional state 583.73 11.57 1880 938318 282518 69705728
Peripheral swelling 576.27 11.57 5216 934982 231347 69756899
Inflammation 567.76 11.57 2306 937892 76359 69911887
Agitation 555.61 11.57 271 939927 93104 69895142
Suicide attempt 554.47 11.57 181 940017 79329 69908917
Decreased appetite 547.86 11.57 2131 938067 302649 69685597
Fall 543.73 11.57 3551 936647 440545 69547701
Depressed level of consciousness 543.07 11.57 239 939959 87192 69901054
Gastrointestinal disorder 540.20 11.57 2794 937404 102633 69885613
Leukoencephalopathy 532.76 11.57 567 939631 6727 69981519
Malignant neoplasm progression 526.20 11.57 502 939696 121237 69867009
Hallucination 525.83 11.57 177 940021 76083 69912163
Condition aggravated 521.96 11.57 8260 931938 419375 69568871
Hypokalaemia 517.36 11.57 585 939613 130603 69857643
Plasma cell myeloma 515.12 11.57 164 940034 73037 69915209
Stomatitis 514.63 11.57 3188 937010 125323 69862923
Tremor 510.70 11.57 795 939403 154829 69833417
Abdominal discomfort 502.94 11.57 4694 935504 209964 69778282
Loss of personal independence in daily activities 502.62 11.57 2345 937853 82565 69905681
Atrial fibrillation 495.16 11.57 1065 939133 183283 69804963
Sedation 492.81 11.57 32 940166 46699 69941547
Gastrointestinal haemorrhage 492.15 11.57 660 939538 136748 69851498
Nasopharyngitis 488.93 11.57 4795 935403 217411 69770835
Joint stiffness 478.21 11.57 1279 938919 33897 69954349
Pneumocystis jirovecii pneumonia 477.75 11.57 1160 939038 28922 69959324
Lactic acidosis 475.09 11.57 136 940062 64888 69923358
Chronic graft versus host disease 467.69 11.57 511 939687 6259 69981987
Diarrhoea 462.73 11.57 7456 932742 775885 69212361
Bone erosion 456.95 11.57 764 939434 14409 69973837
Diffuse large B-cell lymphoma 456.85 11.57 711 939487 12591 69975655
Osteoarthritis 456.79 11.57 2072 938126 72075 69916171
Coma 450.58 11.57 335 939863 91509 69896737
Asthenia 447.80 11.57 3896 936302 453770 69534476
Metabolic acidosis 443.48 11.57 215 939983 74131 69914115
Multiple sclerosis relapse 443.34 11.57 33 940165 42984 69945262
Mobility decreased 431.22 11.57 2585 937613 100414 69887832
Hand deformity 427.86 11.57 2270 937928 84212 69904034
Respiratory arrest 422.37 11.57 98 940100 53835 69934411
Epstein-Barr virus associated lymphoproliferative disorder 420.59 11.57 349 939849 2940 69985306
Haemoglobin decreased 418.06 11.57 1360 938838 203799 69784447
Rheumatoid factor positive 415.07 11.57 1499 938699 46901 69941345
Cardiac failure 405.04 11.57 806 939392 142735 69845511
Rheumatoid nodule 400.58 11.57 718 939480 14349 69973897
Epstein-Barr virus infection 396.72 11.57 664 939534 12534 69975712
Nodule 396.07 11.57 841 939357 19128 69969118
Oedema peripheral 394.93 11.57 1618 938580 226473 69761773
Therapeutic response decreased 394.65 11.57 1679 938519 56774 69931472
Drug reaction with eosinophilia and systemic symptoms 392.43 11.57 139 940059 57874 69930372
Product use issue 387.91 11.57 3867 936331 176070 69812176
Loss of consciousness 383.83 11.57 942 939256 154774 69833472
Tachycardia 382.33 11.57 970 939228 157576 69830670
Orthostatic hypotension 382.13 11.57 106 940092 51637 69936609
Pulmonary fibrosis 379.32 11.57 1158 939040 33152 69955094
Drug clearance decreased 373.46 11.57 314 939884 2699 69985547
Anxiety 371.48 11.57 1579 938619 218751 69769495
Foot deformity 367.80 11.57 833 939365 19822 69968424
Sinusitis 367.53 11.57 3642 936556 165553 69822693
Epstein Barr virus positive mucocutaneous ulcer 366.93 11.57 189 940009 607 69987639
Serotonin syndrome 360.12 11.57 62 940136 42052 69946194
Sopor 360.04 11.57 12 940186 31255 69956991
Blood glucose increased 359.30 11.57 504 939694 102478 69885768
Tuberculosis 356.30 11.57 677 939521 14171 69974075
Herpes zoster 355.99 11.57 2138 938060 83097 69905149
Balance disorder 342.27 11.57 414 939784 89714 69898532
Platelet count decreased 340.23 11.57 1215 938983 177007 69811239
Aggression 332.99 11.57 113 940085 48333 69939913
Juvenile idiopathic arthritis 331.68 11.57 397 939801 5403 69982843
Ankylosing spondylitis 331.65 11.57 572 939626 11074 69977172
Systemic lupus erythematosus 327.41 11.57 2394 937804 99508 69888738
Musculoskeletal pain 323.56 11.57 2179 938019 88148 69900098
Injection site erythema 315.96 11.57 1847 938351 71077 69917169
Pneumonia aspiration 314.91 11.57 220 939978 62069 69926177
Seizure 314.51 11.57 1252 938946 176710 69811536
Blood creatine phosphokinase increased 312.87 11.57 214 939984 61049 69927197
Injection site bruising 311.86 11.57 1161 939037 36871 69951375
Graft versus host disease 309.93 11.57 643 939555 14380 69973866
Chest pain 307.46 11.57 2008 938190 249252 69738994
Neuroleptic malignant syndrome 302.99 11.57 9 940189 25998 69962248
Angiocentric lymphoma 302.90 11.57 177 940021 776 69987470
Myelopathy 302.62 11.57 326 939872 3925 69984321
Injection site reaction 300.97 11.57 1385 938813 48467 69939779
Acute graft versus host disease in skin 300.69 11.57 420 939778 6717 69981529
Intentional self-injury 300.18 11.57 34 940164 31616 69956630
Grip strength decreased 295.51 11.57 647 939551 15038 69973208
Acute myocardial infarction 293.89 11.57 319 939879 72568 69915678
Unresponsive to stimuli 292.15 11.57 162 940036 51769 69936477
Hospitalisation 291.11 11.57 401 939797 82167 69906079
Joint range of motion decreased 291.06 11.57 882 939316 25144 69963102
Cerebrovascular accident 287.36 11.57 958 939240 142512 69845734
Lymphoma 287.00 11.57 634 939564 14828 69973418
Knee arthroplasty 279.49 11.57 1045 939153 33256 69954990
Posterior reversible encephalopathy syndrome 274.80 11.57 829 939369 23573 69964673
Disease progression 273.17 11.57 1108 939090 155564 69832682
Coronary artery disease 270.65 11.57 259 939939 62477 69925769
Hypoxia 268.56 11.57 518 939680 92826 69895420
Drug withdrawal syndrome 267.24 11.57 54 940144 32661 69955585
Vomiting 265.64 11.57 5916 934282 587195 69401051
Hypomagnesaemia 263.43 11.57 105 940093 40659 69947587
Fluid retention 262.73 11.57 271 939927 63114 69925132
Device expulsion 258.07 11.57 8 940190 22238 69966008
Blood creatinine increased 256.47 11.57 1000 939198 142001 69846245
Lower respiratory tract infection 254.65 11.57 2433 937765 109480 69878766
Hyperhidrosis 254.45 11.57 892 939306 130694 69857552
Finger deformity 253.91 11.57 358 939840 5778 69982468
Cognitive disorder 251.10 11.57 262 939936 60694 69927552
Anti-cyclic citrullinated peptide antibody positive 250.66 11.57 1692 938506 68493 69919753
Myocardial infarction 248.12 11.57 1300 938898 170345 69817901
Musculoskeletal disorder 247.44 11.57 702 939496 19269 69968977
Dactylitis 246.91 11.57 218 939980 2015 69986231
Delirium 243.84 11.57 382 939816 74232 69914014
Disorientation 240.81 11.57 247 939951 57676 69930570
Restlessness 240.50 11.57 129 940069 41999 69946247
Off label use 239.89 11.57 12089 928109 730971 69257275
Abnormal behaviour 238.47 11.57 81 940117 34628 69953618
Suicidal ideation 237.40 11.57 346 939852 69250 69918996
Respiratory depression 237.20 11.57 26 940172 24805 69963441
Angioedema 236.31 11.57 322 939876 66288 69921958
Basal cell carcinoma 235.25 11.57 978 939220 32720 69955526
Pulmonary embolism 234.63 11.57 1164 939034 154703 69833543
Blood urea increased 233.58 11.57 161 940037 45748 69942498
Melaena 233.51 11.57 241 939957 56114 69932132
Hypersensitivity 233.47 11.57 4312 935886 225500 69762746
Histoplasmosis disseminated 232.88 11.57 204 939994 1864 69986382
Pulmonary tuberculosis 232.21 11.57 392 939806 7453 69980793
Hyperglycaemia 230.07 11.57 312 939886 64360 69923886
Uveitis 229.90 11.57 567 939631 14278 69973968
Bone marrow failure 229.17 11.57 1267 938931 47743 69940503
Injection site pruritus 229.06 11.57 1079 939119 38131 69950115
Joint effusion 229.04 11.57 581 939617 14896 69973350
Pulmonary oedema 225.21 11.57 470 939728 81808 69906438
Mental status changes 223.89 11.57 305 939893 62796 69925450
Renal failure 222.16 11.57 1529 938669 187541 69800705
Cardiogenic shock 221.10 11.57 102 940096 36205 69952041
Arthritis bacterial 220.99 11.57 394 939804 7839 69980407
Tuberculin test positive 220.74 11.57 243 939955 3003 69985243
Intentional product misuse 218.43 11.57 454 939744 79141 69909105
Impaired healing 214.04 11.57 1703 938495 72671 69915575
Blood calcium decreased 213.16 11.57 59 940139 28787 69959459
Myalgia 212.79 11.57 1327 938871 166565 69821681
Pemphigus 211.60 11.57 1850 938348 81186 69907060
Haematotoxicity 211.47 11.57 522 939676 13152 69975094
White blood cell count decreased 209.88 11.57 1356 938842 168785 69819461
Disability 207.88 11.57 549 939649 14434 69973812
Urinary retention 207.17 11.57 234 939964 52286 69935960
Skin ulcer 206.31 11.57 1216 938982 46929 69941317
Hallucination, visual 205.88 11.57 66 940132 29271 69958975
Chest discomfort 204.81 11.57 899 939299 123482 69864764
Blood pressure decreased 202.38 11.57 584 939614 90931 69897315
Myoclonus 202.20 11.57 50 940148 26305 69961941
Dyspnoea exertional 201.48 11.57 464 939734 77966 69910280
Pulmonary hypertension 200.87 11.57 192 940006 46344 69941902
Polyarthritis 200.72 11.57 442 939756 10314 69977932
Injection site swelling 199.32 11.57 1112 939086 42045 69946201
Sinus bradycardia 199.31 11.57 36 940162 23587 69964659
Ventricular tachycardia 197.22 11.57 119 940079 36304 69951942
Blood potassium decreased 196.32 11.57 164 940034 42257 69945989
Diabetic ketoacidosis 195.85 11.57 86 940112 31426 69956820
Tenosynovitis 195.84 11.57 514 939684 13462 69974784
Osteoporosis 195.42 11.57 1213 938985 47694 69940552
Diverticulitis 192.52 11.57 1075 939123 40659 69947587
Dysgeusia 191.53 11.57 224 939974 49278 69938968
Psychotic disorder 190.76 11.57 133 940065 37568 69950678
Product use in unapproved indication 189.93 11.57 3832 936366 203646 69784600
Dyskinesia 189.83 11.57 159 940039 40915 69947331
Venoocclusive liver disease 189.40 11.57 430 939768 10248 69977998
Immunosuppression 188.73 11.57 449 939749 11043 69977203
Vision blurred 187.57 11.57 638 939560 94346 69893900
Fibromyalgia 186.68 11.57 1180 939018 46694 69941552
Product dose omission issue 185.76 11.57 1913 938285 215555 69772691
Poisoning deliberate 184.98 11.57 10 940188 17050 69971196
Exposure during pregnancy 183.74 11.57 574 939624 87143 69901103
Flushing 183.44 11.57 522 939676 81650 69906596
Hypervolaemia 181.91 11.57 155 940043 39551 69948695
Torsade de pointes 180.83 11.57 16 940182 18100 69970146
Asthma 180.65 11.57 904 939294 119889 69868357
Arrhythmia 178.20 11.57 293 939905 55850 69932396
Haemophagocytic lymphohistiocytosis 177.18 11.57 618 939580 18994 69969252
Extrapyramidal disorder 176.41 11.57 31 940167 20719 69967527
Blood alkaline phosphatase increased 176.06 11.57 316 939882 58205 69930041
Hypocalcaemia 175.70 11.57 201 939997 44658 69943588
Febrile bone marrow aplasia 174.18 11.57 447 939751 11544 69976702
Palpitations 171.32 11.57 819 939379 109934 69878312
Pericarditis 171.15 11.57 1797 938401 82908 69905338
Joint destruction 170.43 11.57 257 939941 4421 69983825
Wheezing 168.50 11.57 659 939539 93511 69894735
Infusion related reaction 167.60 11.57 3608 936590 193926 69794320
Withdrawal syndrome 166.15 11.57 61 940137 24843 69963403
Neuropathy peripheral 164.91 11.57 995 939203 125901 69862345
Upper gastrointestinal haemorrhage 164.83 11.57 152 940046 37325 69950921
Blood sodium decreased 164.06 11.57 104 940094 30894 69957352
Neurotoxicity 163.55 11.57 806 939392 29020 69959226
Visceral leishmaniasis 162.71 11.57 124 940074 911 69987335
Pulmonary arterial hypertension 162.18 11.57 119 940079 32736 69955510
Miosis 160.30 11.57 6 940192 14095 69974151
Dystonia 159.97 11.57 33 940165 19673 69968573
Acute lymphocytic leukaemia recurrent 157.19 11.57 254 939944 4650 69983596
Product quality issue 155.70 11.57 107 940091 30454 69957792
Poisoning 155.05 11.57 53 940145 22569 69965677
Circulatory collapse 154.70 11.57 145 940053 35329 69952917
Neutrophil count decreased 154.48 11.57 577 939621 82979 69905267
Acute respiratory failure 153.30 11.57 299 939899 53366 69934880
Rash maculo-papular 152.89 11.57 272 939926 50273 69937973
Haematemesis 151.78 11.57 258 939940 48539 69939707
Cerebral haemorrhage 151.37 11.57 303 939895 53561 69934685
Tubulointerstitial nephritis 150.45 11.57 130 940068 32946 69955300
Delusion 149.69 11.57 35 940163 19130 69969116
Glossodynia 149.33 11.57 1779 938419 84708 69903538
Right ventricular failure 147.86 11.57 55 940143 22219 69966027
Disturbance in attention 146.52 11.57 213 939985 42681 69945565
Infective pulmonary exacerbation of cystic fibrosis 146.22 11.57 3 940195 12155 69976091
Lethargy 146.16 11.57 509 939689 74741 69913505
Lymphocyte count decreased 145.99 11.57 219 939979 43320 69944926
Epidermal necrosis 145.48 11.57 133 940065 1292 69986954
Acute graft versus host disease in intestine 145.26 11.57 214 939984 3602 69984644
Palmar-plantar erythrodysaesthesia syndrome 144.88 11.57 113 940085 30134 69958112
Pulmonary mass 144.53 11.57 706 939492 25327 69962919
Breast cancer 144.14 11.57 848 939350 32701 69955545
Premature delivery 144.14 11.57 51 940147 21253 69966993
Mycobacterium tuberculosis complex test positive 143.88 11.57 166 940032 2167 69986079
Fine motor skill dysfunction 143.37 11.57 247 939951 4777 69983469
Nightmare 143.27 11.57 57 940141 22099 69966147
Blood pressure fluctuation 142.22 11.57 1299 938899 57713 69930533
Fear of injection 141.66 11.57 289 939909 6383 69981863
Mania 141.00 11.57 28 940170 17146 69971100
Disseminated tuberculosis 140.58 11.57 219 939979 3881 69984365
Graft versus host disease in gastrointestinal tract 140.12 11.57 269 939929 5675 69982571
Impaired work ability 139.98 11.57 506 939692 15834 69972412
Synovial cyst 139.73 11.57 338 939860 8404 69979842
Latent tuberculosis 139.51 11.57 189 940009 2932 69985314
Graft versus host disease in skin 139.17 11.57 260 939938 5370 69982876
Atrial flutter 138.66 11.57 48 940150 20279 69967967
Schizophrenia 138.37 11.57 27 940171 16741 69971505
Full blood count decreased 138.35 11.57 72 940126 23846 69964400
Muscle rigidity 136.22 11.57 39 940159 18611 69969635
Chronic kidney disease 136.18 11.57 388 939810 60669 69927577
Device dislocation 135.85 11.57 64 940134 22443 69965803
Enthesopathy 135.57 11.57 383 939815 10486 69977760
Anhedonia 135.46 11.57 15 940183 14198 69974048
Deep vein thrombosis 135.35 11.57 888 939310 110154 69878092
Wound 135.35 11.57 1947 938251 96785 69891461
Creatinine renal clearance decreased 135.16 11.57 31 940167 17169 69971077
Pustular psoriasis 134.52 11.57 230 939968 4420 69983826
Oedema 134.15 11.57 813 939385 102768 69885478
Hepatic encephalopathy 133.34 11.57 63 940135 22055 69966191
Abdominal distension 133.23 11.57 826 939372 103843 69884403
Gastrooesophageal reflux disease 132.87 11.57 685 939513 90154 69898092
Chronic obstructive pulmonary disease 132.80 11.57 553 939645 77088 69911158
Hepatotoxicity 131.94 11.57 1017 939181 42969 69945277
Presyncope 131.75 11.57 182 940016 37256 69950990
Rheumatoid lung 131.70 11.57 194 940004 3265 69984981
Depression 131.03 11.57 1852 938346 197122 69791124
Ventricular fibrillation 130.22 11.57 101 940097 27010 69961236
Febrile neutropenia 130.19 11.57 3589 936609 200729 69787517
Jaundice 129.85 11.57 295 939903 49813 69938433
Eosinophilia 129.28 11.57 209 939989 40110 69948136
Malignant melanoma 129.04 11.57 442 939756 13458 69974788
Akathisia 127.90 11.57 9 940189 12284 69975962
Lung disorder 127.86 11.57 1447 938751 68037 69920209
Altered state of consciousness 127.82 11.57 208 939990 39814 69948432
Renal impairment 127.47 11.57 1255 938943 142682 69845564
Irritability 125.54 11.57 195 940003 38030 69950216
Injection site haemorrhage 125.44 11.57 669 939529 24858 69963388
Dysphagia 125.39 11.57 927 939271 111907 69876339
Haemoptysis 125.31 11.57 313 939885 51139 69937107
Cardiac disorder 124.98 11.57 388 939810 59027 69929219
Injection site warmth 124.33 11.57 435 939763 13390 69974856
Stevens-Johnson syndrome 123.93 11.57 177 940021 35730 69952516
Parkinsonism 123.71 11.57 26 940172 15299 69972947
Sensitivity to weather change 123.42 11.57 291 939907 7114 69981132
Hypofibrinogenaemia 123.21 11.57 139 940059 1768 69986478
B-cell lymphoma 123.12 11.57 263 939935 6006 69982240
Cutaneous leishmaniasis 121.76 11.57 66 940132 242 69988004
Hypothermia 120.60 11.57 61 940137 20533 69967713
Head injury 120.12 11.57 166 940032 33975 69954271
Respiratory failure 119.96 11.57 1546 938652 167189 69821057
Sarcoidosis 119.91 11.57 269 939929 6358 69981888
Haematocrit decreased 119.67 11.57 375 939823 56883 69931363
Panniculitis 119.54 11.57 362 939836 10314 69977932
Haematoma 119.13 11.57 293 939905 48125 69940121
Haematuria 118.82 11.57 437 939761 63136 69925110
Abdominal pain 118.70 11.57 3540 936658 338587 69649659
Oral herpes 118.27 11.57 633 939565 23553 69964693
Muscle spasms 117.97 11.57 1389 938809 152657 69835589
Contraindication to medical treatment 117.87 11.57 109 940089 1076 69987170
Interstitial lung disease 117.82 11.57 1997 938201 102688 69885558
Ill-defined disorder 117.55 11.57 1176 939022 53565 69934681
Inappropriate schedule of product administration 116.45 11.57 2039 938159 105516 69882730
Substance abuse 116.09 11.57 3 940195 9834 69978412
Joint injury 114.58 11.57 679 939519 26253 69961993
Paranoia 114.23 11.57 43 940155 17245 69971001
Neoplasm progression 114.20 11.57 270 939928 44958 69943288
Kidney transplant rejection 114.06 11.57 4 940194 9957 69978289
Hallucination, auditory 113.93 11.57 50 940148 18278 69969968
Ascites 113.11 11.57 485 939713 67062 69921184
Sinus tachycardia 112.33 11.57 172 940026 33741 69954505
Atrioventricular block first degree 112.06 11.57 12 940186 11661 69976585
Muscle twitching 111.29 11.57 62 940136 19765 69968481
Mucocutaneous ulceration 111.23 11.57 65 940133 285 69987961
Discomfort 110.65 11.57 1989 938209 103447 69884799
Aphthous ulcer 109.14 11.57 434 939764 14222 69974024
Electrolyte imbalance 108.88 11.57 117 940081 26744 69961502
Skin plaque 108.87 11.57 331 939867 9452 69978794
Histoplasmosis 107.78 11.57 137 940061 1990 69986256
Demyelination 107.44 11.57 272 939926 6964 69981282
Pulmonary toxicity 107.01 11.57 351 939847 10447 69977799
Hyperthyroidism 106.88 11.57 67 940131 20024 69968222
Subdural haematoma 106.58 11.57 139 940059 29159 69959087
Joint arthroplasty 103.91 11.57 148 940050 2412 69985834
Haemorrhage 103.28 11.57 668 939530 83147 69905099
Emotional distress 102.95 11.57 211 939987 36977 69951269
Hip arthroplasty 102.49 11.57 680 939518 27360 69960886
Wrist deformity 102.47 11.57 125 940073 1737 69986509
Leukocytosis 102.41 11.57 234 939964 39434 69948812
Hypophosphataemia 102.34 11.57 44 940154 16282 69971964
Heparin-induced thrombocytopenia 102.20 11.57 4 940194 9033 69979213
Sleep disorder due to general medical condition, insomnia type 102.12 11.57 817 939381 34915 69953331
Ulcer 101.77 11.57 637 939561 25117 69963129
Swollen tongue 101.03 11.57 212 939986 36834 69951412
Speech disorder 101.02 11.57 338 939860 50242 69938004
Oropharyngeal pain 100.41 11.57 1815 938383 94495 69893751
Arthrodesis 99.11 11.57 136 940062 2137 69986109
Tardive dyskinesia 98.48 11.57 9 940189 9920 69978326
Troponin increased 97.61 11.57 49 940149 16565 69971681
Thrombocytopenia 97.15 11.57 2419 937779 236691 69751555
Blood potassium increased 97.00 11.57 132 940066 27194 69961052
Cystitis haemorrhagic 96.81 11.57 292 939906 8301 69979945
Deformity 96.37 11.57 285 939913 8012 69980234
Drug tolerance decreased 95.98 11.57 318 939880 9515 69978731
Blood glucose decreased 95.97 11.57 107 940091 24052 69964194
Cytokine release syndrome 95.83 11.57 126 940072 26341 69961905
Cytomegalovirus chorioretinitis 95.80 11.57 215 939983 5083 69983163
Dysarthria 95.63 11.57 462 939736 61851 69926395
Hepatic steatosis 95.48 11.57 771 939427 33042 69955204
Caesarean section 95.13 11.57 19 940179 11588 69976658
Hospice care 95.00 11.57 3 940195 8202 69980044
Sacroiliitis 94.82 11.57 162 940036 3111 69985135
Transfusion 94.56 11.57 67 940131 18769 69969477
Dysuria 94.24 11.57 302 939896 45492 69942754
Myocardial ischaemia 94.15 11.57 109 940089 24091 69964155
Lupus-like syndrome 93.94 11.57 351 939847 11164 69977082
Cataract 93.15 11.57 1138 939060 54507 69933739
Helicobacter infection 92.64 11.57 1137 939061 54519 69933727
Salivary hypersecretion 92.62 11.57 28 940170 12897 69975349
Folliculitis 92.60 11.57 917 939281 41653 69946593
Blood bilirubin increased 92.00 11.57 444 939754 59457 69928789
Electrocardiogram QRS complex prolonged 91.83 11.57 11 940187 9795 69978451
Atrioventricular block 91.81 11.57 27 940171 12661 69975585
Supraventricular tachycardia 91.44 11.57 76 940122 19634 69968612
Transient ischaemic attack 90.41 11.57 309 939889 45635 69942611
Elbow deformity 90.35 11.57 104 940094 1354 69986892
Atrioventricular block complete 90.17 11.57 44 940154 15119 69973127
Neck pain 89.95 11.57 1311 938887 65346 69922900
Hypovolaemia 89.78 11.57 50 940148 15943 69972303
Chronic graft versus host disease in skin 89.60 11.57 104 940094 1367 69986879
Leukaemia recurrent 89.31 11.57 144 940054 2631 69985615
Hypothyroidism 89.17 11.57 309 939889 45446 69942800
Labelled drug-drug interaction medication error 88.24 11.57 114 940084 24013 69964233
Rectal haemorrhage 88.24 11.57 511 939687 65320 69922926
Chromaturia 87.27 11.57 110 940088 23418 69964828
Blood loss anaemia 87.26 11.57 41 940157 14400 69973846
Bronchospasm 87.23 11.57 104 940094 22688 69965558
Rheumatoid factor negative 86.90 11.57 90 940108 1032 69987214
Ventricular extrasystoles 86.14 11.57 69 940129 18157 69970089
Urinary tract infection 85.96 11.57 2575 937623 246194 69742052
Spinal stenosis 85.40 11.57 403 939795 14250 69973996
Blood magnesium decreased 85.36 11.57 45 940153 14796 69973450
Treatment noncompliance 85.17 11.57 323 939875 46251 69941995
Fear 85.07 11.57 90 940108 20721 69967525
Epilepsy 84.62 11.57 249 939949 38535 69949711
Full blood count abnormal 84.14 11.57 204 939994 33674 69954572
Injury 83.47 11.57 514 939684 64731 69923515
Ejection fraction decreased 83.08 11.57 177 940021 30585 69957661
General physical health deterioration 83.08 11.57 2437 937761 233594 69754652
Acidosis 82.79 11.57 72 940126 18191 69970055
Status epilepticus 82.58 11.57 123 940075 24403 69963843
Chills 82.56 11.57 1385 938813 143401 69844845
Skin lesion 82.46 11.57 826 939372 37634 69950612
Acute hepatic failure 81.81 11.57 151 940047 27521 69960725
Mycobacterium marinum infection 81.24 11.57 59 940139 399 69987847
Shock 80.82 11.57 270 939928 40155 69948091
Heart rate increased 80.52 11.57 959 939239 105189 69883057
Foot operation 80.01 11.57 190 940008 4667 69983579
Spondyloarthropathy 79.72 11.57 79 940119 856 69987390
Peritonitis bacterial 79.67 11.57 13 940185 9171 69979075
Mydriasis 79.08 11.57 59 940139 16094 69972152
Tricuspid valve incompetence 78.66 11.57 72 940126 17745 69970501
Granuloma skin 78.19 11.57 252 939946 7430 69980816
Lip swelling 77.71 11.57 214 939984 33840 69954406
Red blood cell count decreased 77.58 11.57 391 939807 51770 69936476
Insomnia 77.36 11.57 2246 937952 215560 69772686
Aspiration 77.35 11.57 72 940126 17603 69970643
End stage renal disease 76.44 11.57 26 940172 11107 69977139
Irritable bowel syndrome 76.24 11.57 1019 939179 49831 69938415
Transplant rejection 76.07 11.57 77 940121 18094 69970152
Intentional product use issue 76.06 11.57 2109 938089 118033 69870213
Psychomotor hyperactivity 76.03 11.57 56 940142 15377 69972869
Gamma-glutamyltransferase increased 75.92 11.57 379 939819 50306 69937940
Product substitution issue 75.75 11.57 80 940118 18433 69969813
Cyanosis 75.61 11.57 119 940079 23087 69965159
Diabetes mellitus inadequate control 74.86 11.57 115 940083 22530 69965716
White blood cell count increased 74.71 11.57 577 939621 68996 69919250
Neuroendocrine carcinoma of the skin 74.48 11.57 84 940114 1068 69987178
Haemorrhage intracranial 74.32 11.57 134 940064 24643 69963603
Epstein-Barr virus infection reactivation 74.23 11.57 96 940102 1420 69986826
Angina pectoris 74.08 11.57 359 939839 48024 69940222
Electrocardiogram abnormal 73.83 11.57 52 940146 14612 69973634
Depressed mood 73.75 11.57 314 939884 43506 69944740
Muscle injury 73.70 11.57 808 939390 37686 69950560
Urinary incontinence 73.45 11.57 256 939942 37586 69950660
Product administration error 73.14 11.57 178 940020 29345 69958901
Myocarditis 72.73 11.57 85 940113 18708 69969538
Hepatic enzyme abnormal 72.64 11.57 216 939982 6091 69982155
Neutrophil count increased 72.51 11.57 154 940044 26641 69961605
Lymph node tuberculosis 72.47 11.57 78 940120 938 69987308
Bundle branch block right 72.47 11.57 25 940173 10585 69977661
Shoulder arthroplasty 72.07 11.57 136 940062 2831 69985415
Pleurisy 72.03 11.57 289 939909 9510 69978736
Non-alcoholic steatohepatitis 71.92 11.57 110 940088 1917 69986329
Erythema multiforme 71.87 11.57 68 940130 16496 69971750
Flatulence 71.64 11.57 262 939936 37919 69950327
Tenderness 71.35 11.57 504 939694 20706 69967540
Toxic epidermal necrolysis 71.26 11.57 276 939922 39281 69948965
Respiratory distress 71.23 11.57 428 939770 54222 69934024
Localised infection 71.02 11.57 712 939486 32446 69955800
Chemotherapeutic drug level increased 70.77 11.57 49 940149 304 69987942
Faecaloma 70.74 11.57 25 940173 10426 69977820
Respiratory acidosis 70.61 11.57 24 940174 10257 69977989
Sudden death 70.57 11.57 106 940092 20958 69967288
Bradyphrenia 70.45 11.57 22 940176 9924 69978322
Duodenal ulcer perforation 70.44 11.57 1009 939189 50103 69938143
Acute coronary syndrome 70.26 11.57 98 940100 19981 69968265
Faeces discoloured 70.14 11.57 157 940041 26652 69961594
Cerebral infarction 70.06 11.57 312 939886 42697 69945549
Epstein-Barr virus associated lymphoma 70.02 11.57 79 940119 1005 69987241
Cholecystitis chronic 69.61 11.57 19 940179 9357 69978889
Skin cancer 69.43 11.57 359 939839 13177 69975069
X-ray abnormal 69.33 11.57 123 940075 2437 69985809
Dry skin 69.29 11.57 445 939753 55486 69932760
Ileus 69.25 11.57 135 940063 24102 69964144
Bronchitis 68.93 11.57 2039 938159 115204 69873042
Liver disorder 68.70 11.57 1173 939025 60395 69927851
Rheumatoid factor increased 68.49 11.57 91 940107 1384 69986862
Cutaneous T-cell lymphoma 68.29 11.57 122 940076 2431 69985815
Disease recurrence 68.22 11.57 781 939417 36822 69951424
Complications of bone marrow transplant 68.15 11.57 61 940137 575 69987671
Glycosylated haemoglobin increased 68.02 11.57 78 940120 17313 69970933
Inflammatory marker increased 67.75 11.57 273 939925 9001 69979245
Anuria 67.70 11.57 97 940101 19556 69968690
Epistaxis 67.58 11.57 955 939243 101672 69886574
Hodgkin's disease 67.57 11.57 70 940128 803 69987443
Pallor 67.50 11.57 296 939902 40678 69947568
Chondropathy 67.42 11.57 118 940080 2312 69985934
Ankle deformity 67.36 11.57 62 940136 608 69987638
Arachnoiditis 67.26 11.57 63 940135 633 69987613
Erectile dysfunction 67.09 11.57 49 940149 13513 69974733
Dialysis 67.03 11.57 79 940119 17323 69970923
Blood parathyroid hormone decreased 67.02 11.57 267 939931 8757 69979489
Epicondylitis 66.99 11.57 105 940093 1871 69986375
Angina unstable 66.93 11.57 67 940131 15826 69972420
Obstructive airways disorder 66.63 11.57 155 940043 25958 69962288
Limb deformity 66.48 11.57 144 940054 3321 69984925
Ischaemic stroke 66.42 11.57 199 939999 30621 69957625
Acute lymphocytic leukaemia 65.86 11.57 192 940006 5353 69982893
Complications of transplanted kidney 65.86 11.57 3 940195 5931 69982315
Hepatic failure 65.65 11.57 470 939728 57155 69931091
Venoocclusive disease 65.65 11.57 161 940037 4039 69984207
Scleritis 65.51 11.57 147 940051 3475 69984771
Prothrombin time prolonged 65.08 11.57 71 940127 16119 69972127
Granulomatous pneumonitis 64.91 11.57 30 940168 70 69988176
Mitral valve incompetence 64.77 11.57 163 940035 26565 69961681
Acute generalised exanthematous pustulosis 64.73 11.57 65 940133 15332 69972914
Oxygen saturation decreased 64.66 11.57 1119 939079 115310 69872936
Seronegative arthritis 64.35 11.57 140 940058 3239 69985007
Mucosal ulceration 64.27 11.57 98 940100 1703 69986543
Pneumonia cryptococcal 63.96 11.57 86 940112 1324 69986922
Body height below normal 63.28 11.57 100 940098 1795 69986451
Injection site rash 63.04 11.57 403 939795 16007 69972239
Hyperlipidaemia 63.04 11.57 139 940059 23724 69964522
Medial tibial stress syndrome 62.96 11.57 33 940165 111 69988135
Therapy non-responder 62.95 11.57 1398 938800 75517 69912729
Apparent death 62.57 11.57 124 940074 2680 69985566
Infusion site pain 62.30 11.57 38 940160 11526 69976720
Cardiac failure chronic 62.29 11.57 29 940169 10240 69978006
Drug ineffective for unapproved indication 62.28 11.57 783 939415 37755 69950491
Aspartate aminotransferase increased 62.25 11.57 1247 938951 125731 69862515
Tonsillitis 62.11 11.57 201 939997 5939 69982307
SLE arthritis 62.11 11.57 54 940144 488 69987758
Mycobacterium chelonae infection 62.00 11.57 112 940086 2252 69985994
Acute graft versus host disease in liver 61.83 11.57 96 940102 1696 69986550
Polyuria 61.81 11.57 52 940146 13354 69974892
Skin erosion 61.77 11.57 153 940045 3863 69984383
Drug screen positive 61.56 11.57 4 940194 5836 69982410
Catatonia 61.29 11.57 16 940182 8117 69980129
Mental disorder 61.11 11.57 182 940016 28058 69960188
Adenovirus infection 61.07 11.57 234 939964 7534 69980712
Anaphylactic shock 60.92 11.57 223 939975 32267 69955979
Hypersensitivity pneumonitis 60.91 11.57 138 940060 3284 69984962
Angioimmunoblastic T-cell lymphoma 60.87 11.57 53 940145 480 69987766
Euglycaemic diabetic ketoacidosis 60.79 11.57 5 940193 6002 69982244
Drug dependence 60.64 11.57 271 939927 37050 69951196
Hepatic fibrosis 60.57 11.57 202 939996 6065 69982181
Gastric disorder 60.41 11.57 692 939506 32630 69955616
Lung neoplasm malignant 60.29 11.57 546 939652 24196 69964050
Musculoskeletal deformity 60.04 11.57 76 940122 1099 69987147
Secondary immunodeficiency 59.99 11.57 124 940074 2765 69985481
Abscess 59.97 11.57 474 939724 20180 69968066
Bradypnoea 59.82 11.57 3 940195 5456 69982790
Hypoxic-ischaemic encephalopathy 59.81 11.57 12 940186 7296 69980950
Lower gastrointestinal haemorrhage 59.79 11.57 64 940134 14656 69973590
Bronchitis chronic 59.62 11.57 153 940045 3951 69984295
Colorectal cancer 59.53 11.57 19 940179 8451 69979795
Tachypnoea 59.52 11.57 188 940010 28450 69959796
Cytomegalovirus infection 59.30 11.57 796 939402 38962 69949284
Cholestasis 59.24 11.57 381 939817 47491 69940755
Mycobacterial infection 59.14 11.57 138 940060 3350 69984896
Activated partial thromboplastin time prolonged 59.12 11.57 55 940143 13450 69974796
Hypomania 58.91 11.57 6 940192 6066 69982180
Wrong technique in product usage process 58.70 11.57 604 939594 68094 69920152
Investigation abnormal 58.68 11.57 95 940103 1742 69986504
Fungal infection 58.33 11.57 756 939442 36711 69951535
Device occlusion 58.22 11.57 34 940164 10561 69977685
Long QT syndrome 58.14 11.57 3 940195 5324 69982922
Glomerular filtration rate decreased 58.10 11.57 117 940081 20639 69967607
Surgical failure 58.00 11.57 63 940135 766 69987480
Hypercapnia 57.98 11.57 19 940179 8310 69979936
Face oedema 57.85 11.57 162 940036 25477 69962769
Atypical mycobacterial infection 57.79 11.57 84 940114 1396 69986850
Joint noise 57.37 11.57 135 940063 3296 69984950
Immobile 57.24 11.57 203 939995 6291 69981955
Injection site urticaria 57.17 11.57 305 939893 11333 69976913
Granulomatosis with polyangiitis 56.78 11.57 114 940084 2488 69985758
Uterine perforation 56.70 11.57 6 940192 5885 69982361
Bone pain 56.69 11.57 417 939781 50405 69937841
Bone swelling 56.66 11.57 85 940113 1455 69986791
Joint dislocation 56.53 11.57 358 939840 14173 69974073
Renal tubular necrosis 56.38 11.57 141 940057 23030 69965216
Premature labour 56.13 11.57 18 940180 7982 69980264
Oral disorder 56.12 11.57 257 939941 8972 69979274
Generalised tonic-clonic seizure 56.03 11.57 323 939875 41338 69946908
Adverse reaction 55.96 11.57 244 939954 8338 69979908
Hyperthermia 55.74 11.57 84 940114 16587 69971659
Complication associated with device 55.67 11.57 76 940122 15637 69972609
Pneumonia legionella 55.56 11.57 115 940083 2567 69985679
Faecal calprotectin increased 55.35 11.57 157 940041 4308 69983938
Swelling face 55.35 11.57 552 939646 62612 69925634
Unevaluable event 55.32 11.57 433 939765 51630 69936616
Pulseless electrical activity 55.32 11.57 56 940142 13159 69975087
Central nervous system lymphoma 55.24 11.57 104 940094 2161 69986085
Paraesthesia oral 55.20 11.57 74 940124 15343 69972903
Complication of device insertion 55.19 11.57 4 940194 5328 69982918
Varicella zoster virus infection 55.17 11.57 149 940049 3971 69984275
Blood pressure diastolic abnormal 54.86 11.57 373 939825 15131 69973115
Oral mucosal exfoliation 54.84 11.57 80 940118 1334 69986912
Limb discomfort 54.80 11.57 619 939579 29086 69959160
Pleural effusion 54.76 11.57 1341 938857 131523 69856723
Dislocation of vertebra 54.72 11.57 166 940032 4734 69983512
Haemorrhagic stroke 54.69 11.57 34 940164 10208 69978038
Bradykinesia 54.22 11.57 16 940182 7486 69980760
Thinking abnormal 54.04 11.57 48 940150 12003 69976243
Arthritis infective 54.00 11.57 218 939980 7194 69981052
Hypophagia 53.94 11.57 326 939872 41244 69947002
Renal injury 53.90 11.57 81 940117 16013 69972233
Pollakiuria 53.74 11.57 244 939954 33217 69955029
Atrioventricular block second degree 53.69 11.57 12 940186 6766 69981480
Lennox-Gastaut syndrome 53.58 11.57 36 940162 211 69988035
Ischaemic cardiomyopathy 53.49 11.57 14 940184 7090 69981156
Intervertebral disc space narrowing 53.35 11.57 83 940115 1469 69986777
Immunodeficiency 53.25 11.57 407 939791 17148 69971098
Multiple sclerosis 53.25 11.57 165 940033 25120 69963126
Joint lock 53.20 11.57 120 940078 2847 69985399
Pharyngitis streptococcal 52.99 11.57 257 939941 9191 69979055
Asphyxia 52.96 11.57 36 940162 10306 69977940
Pancreatitis acute 52.91 11.57 366 939832 44858 69943388
Therapeutic response shortened 52.90 11.57 321 939877 12517 69975729
Poor venous access 52.87 11.57 360 939838 14611 69973635
Ventricular arrhythmia 52.53 11.57 19 940179 7811 69980435
Urine output decreased 52.51 11.57 90 940108 16880 69971366
Drug specific antibody present 52.49 11.57 182 940016 5576 69982670
Proteinuria 52.24 11.57 206 939992 29168 69959078
Dementia 52.19 11.57 139 940059 22226 69966020
Temporal lobe epilepsy 52.02 11.57 43 940155 360 69987886
Dermatomyositis 51.99 11.57 131 940067 3344 69984902
Electrocardiogram ST segment elevation 51.79 11.57 18 940180 7586 69980660
Drug specific antibody 51.67 11.57 103 940095 2236 69986010
Amyotrophic lateral sclerosis 51.65 11.57 88 940110 1686 69986560
Squamous cell carcinoma of lung 51.65 11.57 101 940097 2161 69986085
Ketoacidosis 51.63 11.57 16 940182 7253 69980993
Paraesthesia 51.58 11.57 1501 938697 144036 69844210
Glioma 51.58 11.57 51 940147 551 69987695
Physical disability 51.45 11.57 116 940082 2751 69985495
Superior sagittal sinus thrombosis 51.40 11.57 65 940133 939 69987307
Vertigo 51.40 11.57 556 939642 62087 69926159
Device difficult to use 51.36 11.57 41 940157 10808 69977438
Glaucoma 51.33 11.57 413 939785 17679 69970567
Brain natriuretic peptide increased 51.25 11.57 22 940176 8149 69980097
Hepatic cirrhosis 51.21 11.57 628 939570 30103 69958143
Failure to thrive 51.17 11.57 41 940157 10788 69977458
Blood pressure diastolic decreased 51.14 11.57 545 939653 25235 69963011
Pharyngitis 51.07 11.57 452 939746 19899 69968347
Exposure to toxic agent 51.05 11.57 10 940188 6184 69982062
Device leakage 50.97 11.57 30 940168 9278 69978968
Gestational diabetes 50.94 11.57 9 940189 5992 69982254
Cytomegalovirus infection reactivation 50.65 11.57 201 939997 6580 69981666
Hepatitis B reactivation 50.34 11.57 171 940027 5184 69983062
Respiratory tract congestion 50.09 11.57 403 939795 17250 69970996
Tooth abscess 49.85 11.57 348 939850 14241 69974005
Engraftment syndrome 49.73 11.57 72 940126 1192 69987054
Mesenteritis 49.62 11.57 36 940162 243 69988003
Blood pressure systolic abnormal 49.58 11.57 317 939881 12592 69975654
Cardiac failure acute 49.44 11.57 98 940100 17389 69970857
Nephrogenic systemic fibrosis 49.40 11.57 10 940188 6042 69982204
Bone cyst 49.05 11.57 114 940084 2760 69985486
Abnormal dreams 49.04 11.57 41 940157 10562 69977684
Somnambulism 49.01 11.57 6 940192 5254 69982992
Myelitis 48.78 11.57 99 940099 2178 69986068
Dermatitis acneiform 48.74 11.57 29 940169 8916 69979330
Extranodal marginal zone B-cell lymphoma (MALT type) 48.67 11.57 49 940149 542 69987704
Pleuropericarditis 48.44 11.57 42 940156 378 69987868
Clinodactyly 48.39 11.57 17 940181 11 69988235
Hyperreflexia 48.36 11.57 19 940179 7423 69980823
Shock haemorrhagic 48.21 11.57 105 940093 18001 69970245
Epstein-Barr virus antigen positive 48 11.57 24 940174 71 69988175
Foot fracture 48.00 11.57 433 939765 19167 69969079
Deafness transitory 47.94 11.57 61 940137 887 69987359
Osteonecrosis of jaw 47.89 11.57 332 939866 40670 69947576
Osteoporotic fracture 47.84 11.57 134 940064 3650 69984596
Angioimmunoblastic T-cell lymphoma stage IV 47.67 11.57 16 940182 7 69988239
Haemodynamic instability 47.58 11.57 84 940114 15574 69972672
Intestinal obstruction 47.53 11.57 310 939888 38515 69949731
Bacterial infection 47.50 11.57 549 939649 25943 69962303
Ophthalmic herpes zoster 47.50 11.57 100 940098 2260 69985986
Adult T-cell lymphoma/leukaemia 47.45 11.57 47 940151 509 69987737
Wrong patient received product 47.43 11.57 3 940195 4477 69983769
Retching 47.41 11.57 87 940111 15892 69972354
Bundle branch block left 47.14 11.57 41 940157 10358 69977888
Device use error 47.09 11.57 15 940183 6681 69981565
Erythrodermic psoriasis 47.02 11.57 82 940116 1602 69986644
Temperature regulation disorder 46.98 11.57 3 940195 4441 69983805
Inappropriate antidiuretic hormone secretion 46.85 11.57 155 940043 23121 69965125
Anger 46.83 11.57 89 940109 16043 69972203
Cancer pain 46.82 11.57 5 940193 4869 69983377
Spinal pain 46.78 11.57 328 939870 13442 69974804
Oral mucosa erosion 46.77 11.57 84 940114 1681 69986565
Atlantoaxial instability 46.76 11.57 36 940162 269 69987977
Vein rupture 46.70 11.57 82 940116 1611 69986635
Hyperprolactinaemia 46.59 11.57 3 940195 4410 69983836
Nasal ulcer 46.41 11.57 85 940113 1728 69986518
Skin necrosis 46.28 11.57 372 939826 15919 69972327
Human antichimeric antibody positive 46.17 11.57 76 940122 1414 69986832
Infusion site erythema 46.14 11.57 21 940177 7514 69980732
Coma scale abnormal 46.10 11.57 25 940173 8091 69980155
Hepatosplenic T-cell lymphoma 45.87 11.57 60 940138 898 69987348
Disability assessment scale score increased 45.50 11.57 113 940085 2858 69985388
Therapy change 45.49 11.57 16 940182 6693 69981553
Inflammatory pain 45.45 11.57 59 940139 876 69987370
Palmoplantar pustulosis 45.40 11.57 46 940152 513 69987733
Forced expiratory volume decreased 45.39 11.57 20 940178 7294 69980952
Memory impairment 45.33 11.57 910 939288 91731 69896515
Mineral metabolism disorder 45.33 11.57 36 940162 283 69987963
Hyperuricaemia 45.30 11.57 47 940151 10919 69977327
Thyroid neoplasm 45.14 11.57 112 940086 2831 69985415
Ear pain 45.13 11.57 562 939636 27037 69961209
Hepatitis cholestatic 45.01 11.57 61 940137 12589 69975657
Ageusia 44.92 11.57 80 940118 14782 69973464
Onychomycosis 44.84 11.57 196 940002 6705 69981541
Thrombosis 44.71 11.57 716 939482 74689 69913557
Gait disturbance 44.70 11.57 2936 937262 182170 69806076
Influenza 44.59 11.57 1888 938310 111812 69876434
Acute pulmonary oedema 44.44 11.57 68 940130 13344 69974902
Cardiomyopathy 44.37 11.57 189 940009 26184 69962062
Chemotherapeutic drug level above therapeutic 44.26 11.57 22 940176 64 69988182
International normalised ratio abnormal 44.25 11.57 8 940190 5239 69983007
Ear infection 44.21 11.57 572 939626 27764 69960482
Abscess limb 44.18 11.57 187 940011 6306 69981940
Episcleritis 44.13 11.57 60 940138 934 69987312
Alcohol interaction 44.12 11.57 5 940193 4648 69983598
Tooth infection 44.12 11.57 371 939827 16092 69972154
Molluscum contagiosum 44 11.57 42 940156 433 69987813
Squamous cell carcinoma 43.97 11.57 338 939860 14266 69973980
Hypernatraemia 43.94 11.57 63 940135 12698 69975548
Arteriosclerosis 43.88 11.57 97 940101 16541 69971705
Cardiomegaly 43.73 11.57 172 940026 24373 69963873
Haemodialysis 43.57 11.57 104 940094 17262 69970984
Encephalitis 43.49 11.57 319 939879 13266 69974980
Synovectomy 43.46 11.57 31 940167 203 69988043
Myelitis transverse 43.42 11.57 80 940118 1634 69986612
Anal fistula 43.33 11.57 177 940021 5873 69982373
Spinal instability 43.31 11.57 38 940160 348 69987898
Sleep apnoea syndrome 43.26 11.57 255 939943 32458 69955788
Hiccups 43.12 11.57 34 940164 9018 69979228
Pre-eclampsia 43.06 11.57 16 940182 6469 69981777
Lymphadenopathy 42.86 11.57 896 939302 47895 69940351
Aplasia 42.67 11.57 200 939998 7051 69981195
Osteopenia 42.50 11.57 372 939826 16325 69971921
Product complaint 42.49 11.57 60 940138 12171 69976075
Alveolitis 42.46 11.57 129 940069 3682 69984564
Blood glucose fluctuation 42.40 11.57 15 940183 6252 69981994
Joint laxity 42.38 11.57 95 940103 2244 69986002
Left ventricular dysfunction 42.36 11.57 111 940087 17846 69970400
Synovial disorder 42.19 11.57 62 940136 1041 69987205
Diffuse large B-cell lymphoma stage IV 42.19 11.57 47 940151 589 69987657
Iritis 42.13 11.57 118 940080 3214 69985032
Oxygen consumption increased 42.02 11.57 6 940192 4674 69983572
Subarachnoid haemorrhage 41.98 11.57 126 940072 19378 69968868
Amylase increased 41.89 11.57 44 940154 10164 69978082
Osteosarcoma 41.70 11.57 39 940159 391 69987855
Systemic infection 41.63 11.57 18 940180 6639 69981607
Gastric haemorrhage 41.41 11.57 78 940120 14107 69974139
Refusal of treatment by patient 41.38 11.57 31 940167 8439 69979807
Lipodystrophy acquired 41.34 11.57 4 940194 4212 69984034
Product monitoring error 41.31 11.57 19 940179 6757 69981489
Extrapulmonary tuberculosis 41.24 11.57 37 940161 350 69987896
Hypoaesthesia oral 41.10 11.57 62 940136 12238 69976008
Azotaemia 41.04 11.57 26 940172 7727 69980519
Post procedural haemorrhage 40.95 11.57 67 940131 12799 69975447
Cholelithiasis 40.94 11.57 415 939783 46925 69941321
Ventricular hypertrophy 40.86 11.57 18 940180 6566 69981680
Incorrect product administration duration 40.78 11.57 50 940148 10774 69977472
Tinnitus 40.75 11.57 296 939902 35880 69952366
Aspiration bone marrow abnormal 40.74 11.57 25 940173 122 69988124
Wrist surgery 40.68 11.57 51 940147 730 69987516
Blood lactic acid increased 40.65 11.57 53 940145 11120 69977126
Varicella 40.52 11.57 103 940095 2644 69985602
Coordination abnormal 40.48 11.57 96 940102 15970 69972276
Performance status decreased 40.38 11.57 12 940186 5589 69982657
Lyme disease 40.22 11.57 106 940092 2783 69985463
Dizziness postural 40.21 11.57 46 940152 10222 69978024
Hyperlactacidaemia 40.14 11.57 9 940189 5063 69983183
Eye disorder 40.11 11.57 437 939761 20348 69967898
Morphoea 40.09 11.57 38 940160 388 69987858
Small intestinal obstruction 40.07 11.57 179 940019 24476 69963770
Priapism 40.04 11.57 4 940194 4106 69984140
Bone tuberculosis 39.73 11.57 41 940157 468 69987778
Mood altered 39.51 11.57 101 940097 16374 69971872
Knee deformity 39.49 11.57 57 940141 941 69987305
Dry mouth 39.48 11.57 676 939522 69781 69918465
Throat tightness 39.27 11.57 184 940014 24838 69963408
Device breakage 39.14 11.57 40 940158 9358 69978888
Metabolic encephalopathy 39.10 11.57 32 940166 8331 69979915
Therapeutic product effect delayed 39.01 11.57 102 940096 2665 69985581
Personality change 38.97 11.57 36 940162 8834 69979412
Pseudomonal sepsis 38.87 11.57 161 940037 5376 69982870
Rash 38.75 11.57 7502 932696 503060 69485186
Psychomotor retardation 38.56 11.57 13 940185 5585 69982661
Bursitis 38.54 11.57 531 939667 26142 69962104
Hallucinations, mixed 38.54 11.57 18 940180 6344 69981902
Abscess bacterial 38.44 11.57 50 940148 744 69987502
Pemphigoid 38.43 11.57 80 940118 13942 69974304
Hypophysitis 38.39 11.57 3 940195 3755 69984491
Rhinorrhoea 38.38 11.57 1152 939046 65219 69923027
Blood prolactin increased 38.34 11.57 3 940195 3751 69984495
Body temperature decreased 38.31 11.57 563 939635 28109 69960137
Exostosis 38.30 11.57 323 939875 14022 69974224
Transaminases increased 38.27 11.57 854 939344 46164 69942082
Rheumatic disorder 38.17 11.57 93 940105 2323 69985923
Hepatitis B virus test positive 38.08 11.57 39 940159 441 69987805
Ovarian neoplasm 38.05 11.57 43 940155 548 69987698
Tonsillar ulcer 37.98 11.57 37 940161 392 69987854
Sciatica 37.94 11.57 496 939702 24131 69964115
Peritoneal tuberculosis 37.91 11.57 41 940157 496 69987750
Metastases to bone 37.86 11.57 160 940038 22216 69966030
Respiration abnormal 37.76 11.57 22 940176 6842 69981404
Neutropenia 37.75 11.57 2915 937283 254241 69734005
Arteriosclerosis coronary artery 37.67 11.57 101 940097 16114 69972132
Adverse drug reaction 37.66 11.57 950 939248 52394 69935852
Tuberculous pleurisy 37.64 11.57 44 940154 583 69987663
Clonus 37.56 11.57 18 940180 6250 69981996
Cyst 37.53 11.57 293 939905 12426 69975820
Toxic skin eruption 37.40 11.57 139 940059 20023 69968223
Breast cancer stage I 37.37 11.57 17 940181 6085 69982161
Aplasia pure red cell 37.32 11.57 26 940172 7348 69980898
Granulocytopenia 37.22 11.57 52 940146 10595 69977651
Vascular device infection 37.20 11.57 31 940167 7999 69980247
Neoplasm recurrence 37.18 11.57 126 940072 3815 69984431
Joint ankylosis 36.98 11.57 71 940127 1498 69986748
Nail psoriasis 36.94 11.57 39 940159 458 69987788
C-reactive protein decreased 36.91 11.57 92 940106 2332 69985914
Human rhinovirus test positive 36.84 11.57 37 940161 408 69987838
Hepatitis E 36.79 11.57 98 940100 2590 69985656
Lung cancer metastatic 36.76 11.57 114 940084 3291 69984955
Blood chloride decreased 36.75 11.57 30 940168 7820 69980426
Alcohol abuse 36.71 11.57 11 940187 5096 69983150
Angioimmunoblastic T-cell lymphoma stage III 36.70 11.57 11 940187 0 69988246
Blood bicarbonate decreased 36.70 11.57 10 940188 4931 69983315
Bone disorder 36.70 11.57 374 939824 17116 69971130
Granuloma 36.67 11.57 200 939998 7495 69980751
Hypotonia 36.65 11.57 63 940135 11802 69976444
Pericardial effusion 36.64 11.57 365 939833 41411 69946835
Normal newborn 36.38 11.57 19 940179 6281 69981965
Blood pressure diastolic increased 36.32 11.57 285 939913 12106 69976140
Osteosclerosis 36.32 11.57 120 940078 3585 69984661
No adverse event 36.25 11.57 263 939935 31890 69956356
Lung adenocarcinoma 36.07 11.57 199 939999 7491 69980755
International normalised ratio decreased 35.99 11.57 29 940169 7609 69980637
Cardioactive drug level increased 35.95 11.57 3 940195 3559 69984687
Dyspnoea at rest 35.91 11.57 23 940175 6796 69981450
Axial spondyloarthritis 35.75 11.57 38 940160 450 69987796
Joint space narrowing 35.70 11.57 35 940163 374 69987872
Organising pneumonia 35.69 11.57 242 939956 9808 69978438
Carcinoma in situ of skin 35.62 11.57 25 940173 159 69988087
Clear cell renal cell carcinoma 35.52 11.57 88 940110 2222 69986024
Blood phosphorus increased 35.43 11.57 23 940175 6747 69981499
Joint warmth 35.39 11.57 69 940129 1473 69986773
Nail disorder 35.24 11.57 248 939950 10176 69978070
Lung transplant 35.20 11.57 7 940191 4283 69983963
Viral vasculitis 35.16 11.57 23 940175 128 69988118
Cold sweat 35.16 11.57 112 940086 16904 69971342
Coronary arterial stent insertion 35.13 11.57 17 940181 5870 69982376
Alcohol use 35.06 11.57 9 940189 4618 69983628
Skin mass 35.00 11.57 193 940005 7263 69980983
Hypovolaemic shock 34.90 11.57 56 940142 10781 69977465
Sputum increased 34.80 11.57 6 940192 4066 69984180
Cerebral haematoma 34.78 11.57 28 940170 7350 69980896
Palindromic rheumatism 34.77 11.57 35 940163 387 69987859
Disturbance in social behaviour 34.74 11.57 6 940192 4061 69984185
Infective tenosynovitis 34.59 11.57 33 940165 340 69987906
Obsessive-compulsive disorder 34.42 11.57 14 940184 5356 69982890
Mucosal toxicity 34.41 11.57 41 940157 555 69987691
Non-Hodgkin's lymphoma 34.39 11.57 69 940129 1505 69986741
Multiple injuries 34.33 11.57 3 940195 3428 69984818
Blood thyroid stimulating hormone increased 34.29 11.57 37 940161 8442 69979804
Acute promyelocytic leukaemia 34.21 11.57 67 940131 1435 69986811
Incoherent 34.10 11.57 28 940170 7278 69980968
Diastolic dysfunction 34.06 11.57 45 940153 9388 69978858
Obliterative bronchiolitis 34.01 11.57 99 940099 2758 69985488
Thrombosis in device 33.98 11.57 13 940185 5162 69983084
Rhinitis allergic 33.91 11.57 44 940154 9251 69978995
Secretion discharge 33.89 11.57 290 939908 12643 69975603
Neoplasm malignant 33.85 11.57 553 939645 28221 69960025
Behaviour disorder 33.81 11.57 15 940183 5449 69982797
Taste disorder 33.77 11.57 62 940136 11323 69976923
Urine ketone body present 33.68 11.57 3 940195 3376 69984870
Leishmaniasis 33.59 11.57 32 940166 329 69987917
Spinal column injury 33.59 11.57 79 940119 1928 69986318
Duodenal ulcer haemorrhage 33.59 11.57 24 940174 6694 69981552
Iridocyclitis 33.58 11.57 109 940089 3226 69985020
Viral upper respiratory tract infection 33.57 11.57 211 939987 8331 69979915
Rheumatoid vasculitis 33.51 11.57 36 940162 432 69987814
Compartment syndrome 33.47 11.57 9 940189 4477 69983769
Cutaneous lymphoma 33.45 11.57 28 940170 239 69988007
Myelodysplastic syndrome 33.41 11.57 568 939630 29217 69959029
Epstein-Barr virus test positive 33.40 11.57 54 940144 989 69987257
Spinal disorder 33.33 11.57 223 939975 8997 69979249
Bloody discharge 33.23 11.57 72 940126 1661 69986585
Diffuse large B-cell lymphoma stage III 33.08 11.57 21 940177 110 69988136
Product prescribing error 33.05 11.57 343 939855 38609 69949637
Amnesia 33.04 11.57 489 939709 51666 69936580
Rheumatic fever 33.03 11.57 369 939829 17291 69970955
Cerebral venous sinus thrombosis 32.97 11.57 79 940119 1952 69986294
T-cell lymphoma 32.94 11.57 61 940137 1251 69986995
Decreased immune responsiveness 32.92 11.57 141 940057 4780 69983466
Adverse event 32.92 11.57 874 939324 48587 69939659
Injection site discolouration 32.91 11.57 183 940015 6909 69981337
Blood stem cell transplant failure 32.88 11.57 38 940160 497 69987749
Osteomyelitis 32.87 11.57 575 939623 29743 69958503
Second primary malignancy 32.82 11.57 290 939908 12761 69975485
Gout 32.77 11.57 175 940023 22831 69965415
Musculoskeletal discomfort 32.63 11.57 371 939827 17461 69970785
Lip ulceration 32.59 11.57 80 940118 2008 69986238
Acute pulmonary histoplasmosis 32.58 11.57 27 940171 227 69988019
Infusion site swelling 32.51 11.57 21 940177 6177 69982069
Skin papilloma 32.47 11.57 150 940048 5256 69982990
Subdural haemorrhage 32.45 11.57 16 940182 5465 69982781
Muscle tightness 32.33 11.57 67 940131 11695 69976551
Pyoderma gangrenosum 32.21 11.57 116 940082 3623 69984623
Choking 32.12 11.57 61 940137 10999 69977247
Blood pressure inadequately controlled 32.09 11.57 17 940181 5575 69982671
Coronary artery occlusion 32.09 11.57 91 940107 14254 69973992
Intestinal ischaemia 32.09 11.57 70 940128 11994 69976252
Hypoglycaemic coma 32.07 11.57 9 940189 4352 69983894
T-cell type acute leukaemia 32.03 11.57 28 940170 255 69987991
Thirst 31.99 11.57 94 940104 14555 69973691
Urine leukocyte esterase positive 31.98 11.57 5 940193 3640 69984606
Ovarian hyperstimulation syndrome 31.97 11.57 3 940195 3237 69985009
Colitis ulcerative 31.79 11.57 629 939569 33294 69954952
Visual acuity reduced 31.71 11.57 228 939970 27702 69960544
Sickle cell anaemia with crisis 31.71 11.57 20 940178 5958 69982288
Viral mutation identified 31.70 11.57 5 940193 3617 69984629
Swollen joint count increased 31.70 11.57 299 939899 13401 69974845
Inhibitory drug interaction 31.69 11.57 6 940192 3801 69984445
Viral haemorrhagic cystitis 31.66 11.57 73 940125 1758 69986488
Systemic lupus erythematosus rash 31.66 11.57 68 940130 1559 69986687
Bunion operation 31.52 11.57 47 940151 800 69987446
Retinal toxicity 31.51 11.57 61 940137 1295 69986951
Genital haemorrhage 31.48 11.57 19 940179 5796 69982450
Hypergammaglobulinaemia benign monoclonal 31.45 11.57 46 940152 769 69987477
Dry eye 31.41 11.57 602 939596 31680 69956566
Mental impairment 31.33 11.57 120 940078 17135 69971111
Ammonia increased 31.33 11.57 29 940169 7109 69981137
Immune thrombocytopenia 31.30 11.57 111 940087 16213 69972033
Oliguria 31.14 11.57 99 940099 14952 69973294
Herpes simplex 31.10 11.57 255 939943 10977 69977269
Panic attack 31.10 11.57 169 940029 21950 69966296
Breast cancer stage II 31.06 11.57 16 940182 5330 69982916
Iris adhesions 31.05 11.57 37 940161 501 69987745
Keratitis 31.05 11.57 115 940083 3642 69984604
Abdominal wall haematoma 31.02 11.57 10 940188 4420 69983826
Haemolytic anaemia 31.01 11.57 116 940082 16678 69971568
Transaminases abnormal 30.99 11.57 45 940153 747 69987499
Myelodysplastic syndrome transformation 30.93 11.57 41 940157 622 69987624
Underdose 30.92 11.57 245 939953 29138 69959108
Antinuclear antibody positive 30.84 11.57 175 940023 6658 69981588
Mucocutaneous leishmaniasis 30.83 11.57 34 940164 421 69987825
Acute myeloid leukaemia 30.80 11.57 579 939619 30361 69957885
Muscle haemorrhage 30.78 11.57 20 940178 5864 69982382
Application site pain 30.71 11.57 10 940188 4392 69983854
Bursitis infective 30.65 11.57 58 940140 1210 69987036
West Nile viral infection 30.59 11.57 49 940149 890 69987356
Drooling 30.51 11.57 17 940181 5419 69982827
Bronchial carcinoma 30.48 11.57 57 940141 1178 69987068
Carpal tunnel syndrome 30.37 11.57 353 939845 16704 69971542
Epstein-Barr viraemia 30.36 11.57 74 940124 1849 69986397
Thrombotic microangiopathy 30.29 11.57 366 939832 17482 69970764
Pseudostroke 30.27 11.57 16 940182 55 69988191
Immune system disorder 30.16 11.57 228 939970 9573 69978673
Anal abscess 30.12 11.57 202 939996 8156 69980090
Blood triglycerides increased 30.04 11.57 146 940052 19518 69968728
Chronic graft versus host disease in intestine 30.01 11.57 29 940169 304 69987942
Injection site inflammation 29.90 11.57 107 940091 3331 69984915
Intervertebral disc protrusion 29.82 11.57 425 939773 21078 69967168
Blood pH decreased 29.80 11.57 11 940187 4465 69983781
Bicytopenia 29.77 11.57 119 940079 3909 69984337
Leukopenia 29.76 11.57 1712 938486 104848 69883398
Blood pressure systolic increased 29.72 11.57 981 939217 56278 69931968
Eye swelling 29.69 11.57 187 940011 23427 69964819
Abortion spontaneous 29.66 11.57 217 939981 26262 69961984
Cerebral toxoplasmosis 29.65 11.57 77 940121 2003 69986243
Pregnancy with contraceptive device 29.63 11.57 4 940194 3251 69984995
Stillbirth 29.62 11.57 7 940191 3798 69984448
JC virus infection 29.60 11.57 109 940089 3442 69984804
Arteriospasm coronary 29.49 11.57 22 940176 6002 69982244
Communication disorder 29.49 11.57 7 940191 3787 69984459
Oligohydramnios 29.45 11.57 4 940194 3236 69985010
Hyperammonaemic encephalopathy 29.44 11.57 11 940187 4432 69983814
Rales 29.32 11.57 122 940076 17013 69971233
Sudden cardiac death 29.31 11.57 14 940184 4871 69983375
Pulse absent 29.31 11.57 49 940149 9281 69978965
Electrocardiogram T wave inversion 29.31 11.57 15 940183 5016 69983230
Cutaneous vasculitis 29.20 11.57 180 940018 7058 69981188
Vascular access complication 29.13 11.57 69 940129 1692 69986554
Nocturia 29.12 11.57 75 940123 12129 69976117
Central nervous system leukaemia 29.11 11.57 31 940167 368 69987878
Mixed liver injury 29.11 11.57 24 940174 6225 69982021
Tendonitis 29.01 11.57 433 939765 21689 69966557
Pruritus 29.01 11.57 4076 936122 341484 69646762
Coronary artery stenosis 29.00 11.57 70 940128 11574 69976672
Ovarian cancer 29.00 11.57 120 940078 4005 69984241
Enterovirus test positive 28.89 11.57 26 940172 247 69987999
Congestive hepatopathy 28.88 11.57 9 940189 4065 69984181
Blister 28.84 11.57 1619 938579 98907 69889339
Anaemia megaloblastic 28.82 11.57 37 940161 543 69987703
Catheter site haemorrhage 28.75 11.57 14 940184 4817 69983429
Alanine aminotransferase abnormal 28.58 11.57 194 940004 7865 69980381
Colitis ischaemic 28.55 11.57 94 940104 14043 69974203
Coronary artery bypass 28.50 11.57 22 940176 5898 69982348
Toe operation 28.50 11.57 35 940163 490 69987756
Ankle operation 28.31 11.57 50 940148 987 69987259
Gastrointestinal inflammation 28.27 11.57 169 940029 6554 69981692
Meningoencephalitis herpetic 28.22 11.57 70 940128 1769 69986477
Decubitus ulcer 28.22 11.57 95 940103 14096 69974150
Enterovirus infection 28.21 11.57 66 940132 1605 69986641
Eosinophil count increased 28.20 11.57 105 940093 15117 69973129
Homicidal ideation 28.17 11.57 5 940193 3318 69984928
Hereditary angioedema 28.13 11.57 16 940182 5043 69983203
Restless legs syndrome 28.05 11.57 137 940061 18291 69969955
Neck mass 28.05 11.57 120 940078 4066 69984180
Ganglioneuroma 28.04 11.57 20 940178 131 69988115
Q fever 28.03 11.57 24 940174 212 69988034
Cytomegalovirus viraemia 28.03 11.57 257 939941 11428 69976818
Pulmonary arterial pressure increased 28 11.57 11 940187 4298 69983948
Conduction disorder 27.99 11.57 4 940194 3114 69985132
Tongue oedema 27.98 11.57 25 940173 6234 69982012
Insurance issue 27.98 11.57 7 940191 3654 69984592
Mitochondrial toxicity 27.91 11.57 3 940195 2907 69985339
Duodenal ulcer 27.91 11.57 106 940092 15174 69973072
Medication error 27.85 11.57 559 939639 56353 69931893
Iron deficiency anaemia 27.84 11.57 185 940013 22887 69965359
Alcoholism 27.83 11.57 12 940186 4433 69983813
Inadequate analgesia 27.66 11.57 10 940188 4112 69984134
High density lipoprotein decreased 27.63 11.57 10 940188 4109 69984137
Accidental overdose 27.51 11.57 315 939883 34806 69953440
Gastrointestinal pain 27.50 11.57 197 940001 8130 69980116
Pneumonia 27.50 11.57 7256 932942 588976 69399270
Myeloid leukaemia 27.46 11.57 38 940160 602 69987644
Incontinence 27.44 11.57 85 940113 12943 69975303
Nodular regenerative hyperplasia 27.44 11.57 56 940142 1237 69987009
Hepatitis acute 27.40 11.57 94 940104 13868 69974378
Hepatocellular carcinoma 27.34 11.57 59 940139 10149 69978097
Coccidioidomycosis 27.34 11.57 54 940144 1164 69987082
Left ventricular hypertrophy 27.30 11.57 59 940139 10143 69978103
Hyperventilation 27.28 11.57 33 940165 7153 69981093
N-terminal prohormone brain natriuretic peptide increased 27.23 11.57 9 940189 3915 69984331
Accidental exposure to product 27.21 11.57 239 939959 27812 69960434
Hypertensive crisis 27.17 11.57 147 940051 19115 69969131
Myoglobin blood increased 27.14 11.57 4 940194 3043 69985203
Chronic recurrent multifocal osteomyelitis 27.06 11.57 16 940182 72 69988174
Onychomadesis 27.05 11.57 117 940081 3984 69984262
Toxic leukoencephalopathy 27.02 11.57 48 940150 952 69987294
Incorrect disposal of product 27.01 11.57 46 940152 881 69987365
Social avoidant behaviour 26.95 11.57 14 940184 4642 69983604
Gastrointestinal toxicity 26.93 11.57 161 940037 6244 69982002
Sinus arrest 26.90 11.57 5 940193 3210 69985036
Bone density decreased 26.84 11.57 251 939947 11223 69977023
Prostatic specific antigen increased 26.80 11.57 53 940145 9413 69978833
Dermatitis atopic 26.76 11.57 49 940149 8958 69979288
Dissociation 26.70 11.57 6 940192 3370 69984876
Urine abnormality 26.69 11.57 39 940159 7799 69980447
Multiple drug therapy 26.63 11.57 5 940193 3187 69985059
Product residue present 26.63 11.57 6 940192 3364 69984882
Malnutrition 26.53 11.57 159 940039 20158 69968088
Intestinal sepsis 26.53 11.57 42 940156 755 69987491
Cholestatic liver injury 26.50 11.57 11 940187 4157 69984089
Nervousness 26.42 11.57 274 939924 30846 69957400
Engraft failure 26.38 11.57 38 940160 626 69987620
Anaplastic large-cell lymphoma 26.38 11.57 28 940170 331 69987915
Pharyngeal ulceration 26.38 11.57 45 940153 863 69987383
Invasive ductal breast carcinoma 26.36 11.57 149 940049 5660 69982586
Blood sodium increased 26.35 11.57 13 940185 4439 69983807
Graft versus host disease in liver 26.33 11.57 63 940135 1555 69986691
Self-injurious ideation 26.26 11.57 6 940192 3332 69984914
Gastritis 26.23 11.57 424 939774 44167 69944079
Blood phosphorus decreased 26.23 11.57 25 940173 6044 69982202
Herpes virus infection 26.10 11.57 163 940035 6421 69981825
Catheterisation cardiac 26.05 11.57 19 940179 5244 69983002
Extra dose administered 25.98 11.57 35 940163 7242 69981004
Heart rate decreased 25.96 11.57 1037 939161 60978 69927268
Akinesia 25.92 11.57 5 940193 3126 69985120
Lipase increased 25.80 11.57 109 940089 15137 69973109
Cushingoid 25.74 11.57 195 940003 8193 69980053
Traumatic lung injury 25.66 11.57 78 940120 2227 69986019
Nephrogenic anaemia 25.63 11.57 8 940190 3610 69984636
Fracture 25.62 11.57 389 939809 19555 69968691
Hepatitis 25.61 11.57 855 939343 49125 69939121
Tonsil cancer 25.58 11.57 49 940149 1032 69987214
Mucormycosis 25.55 11.57 188 940010 7826 69980420
Cutaneous tuberculosis 25.55 11.57 22 940176 196 69988050
Plantar fasciitis 25.54 11.57 96 940102 3062 69985184
Drug eruption 25.45 11.57 695 939503 38801 69949445
Rash morbilliform 25.35 11.57 21 940177 5434 69982812
Burkitt's lymphoma 25.32 11.57 19 940179 136 69988110
Infected dermal cyst 25.31 11.57 51 940147 1116 69987130
Blood iron abnormal 25.26 11.57 52 940146 1156 69987090
Varicella zoster pneumonia 25.22 11.57 18 940180 118 69988128
Hip fracture 25.17 11.57 246 939952 28017 69960229
Cerebral salt-wasting syndrome 25.12 11.57 17 940181 101 69988145
Laryngitis 25.12 11.57 284 939914 13347 69974899
Rash macular 25.06 11.57 217 939981 25327 69962919
Diabetic metabolic decompensation 25.00 11.57 5 940193 3047 69985199
Pleural fibrosis 24.97 11.57 115 940083 4024 69984222
Bone density abnormal 24.95 11.57 90 940108 2813 69985433
Mucosal disorder 24.86 11.57 96 940102 3102 69985144
Acute myeloid leukaemia recurrent 24.84 11.57 93 940105 2961 69985285
Meningitis haemophilus 24.80 11.57 10 940188 14 69988232
Craniosynostosis 24.80 11.57 15 940183 71 69988175
Photosensitivity reaction 24.76 11.57 377 939821 18963 69969283
Increased appetite 24.73 11.57 66 940132 10547 69977699
Chronic graft versus host disease in liver 24.73 11.57 35 940163 567 69987679
Multiple fractures 24.68 11.57 164 940034 6601 69981645
Jaundice cholestatic 24.67 11.57 53 940145 9131 69979115
Tendon disorder 24.62 11.57 160 940038 6391 69981855
Extrasystoles 24.60 11.57 33 940165 6841 69981405
Anaesthetic complication 24.58 11.57 3 940195 2633 69985613
Limb operation 24.53 11.57 93 940105 2979 69985267
Screaming 24.48 11.57 9 940189 3663 69984583
Blood cholesterol increased 24.48 11.57 1069 939129 63535 69924711
Blood albumin decreased 24.46 11.57 182 940016 21945 69966301
Pericardial haemorrhage 24.46 11.57 13 940185 4255 69983991
PCO2 decreased 24.45 11.57 5 940193 2999 69985247
Hyperkinesia 24.42 11.57 3 940195 2620 69985626
Folate deficiency 24.42 11.57 92 940106 2938 69985308
Meningitis tuberculous 24.42 11.57 51 940147 1146 69987100
Foetal death 24.38 11.57 28 940170 6211 69982035
Logorrhoea 24.37 11.57 12 940186 4102 69984144
Ocular lymphoma 24.33 11.57 16 940182 90 69988156
Choriocarcinoma 24.26 11.57 19 940179 146 69988100
Atelectasis 24.18 11.57 256 939942 28706 69959540
Septic arthritis staphylococcal 24.17 11.57 39 940159 713 69987533
Gait inability 24.17 11.57 807 939391 46368 69941878
Mass excision 24.14 11.57 26 940172 313 69987933
Embolic stroke 24.11 11.57 37 940161 7252 69980994
Therapy cessation 24.11 11.57 308 939890 33368 69954878
Pulmonary congestion 24.10 11.57 215 939983 24939 69963307
Joint tuberculosis 24.06 11.57 19 940179 148 69988098
Bone sarcoma 24.05 11.57 16 940182 92 69988154
Legionella infection 24.02 11.57 39 940159 717 69987529
Stress cardiomyopathy 24.00 11.57 60 940138 9802 69978444
Alcohol poisoning 24.00 11.57 14 940184 4351 69983895
Post procedural infection 23.98 11.57 226 939972 10127 69978119
Haemorrhoids 23.95 11.57 220 939978 25368 69962878
Laryngeal disorder 23.90 11.57 45 940153 935 69987311
Pyrexia 23.89 11.57 7436 932762 599516 69388730
Liver function test abnormal 23.88 11.57 1015 939183 60131 69928115
Tropical infectious disease 23.88 11.57 12 940186 36 69988210
Low density lipoprotein increased 23.85 11.57 44 940154 8021 69980225
Ataxia 23.78 11.57 195 940003 23022 69965224
Cytotoxic oedema 23.78 11.57 27 940171 346 69987900
Application site pruritus 23.72 11.57 9 940189 3592 69984654
Nodal rhythm 23.72 11.57 5 940193 2936 69985310
Interferon gamma release assay positive 23.70 11.57 11 940187 26 69988220
Pulmonary arteriopathy 23.65 11.57 16 940182 95 69988151
Prescribed underdose 23.59 11.57 176 940022 21209 69967037
COVID-19 23.56 11.57 1153 939045 104604 69883642
Herpes zoster oticus 23.56 11.57 28 940170 378 69987868
Skin bacterial infection 23.56 11.57 29 940169 407 69987839
Stupor 23.55 11.57 31 940167 6478 69981768
Pulmonary sarcoidosis 23.55 11.57 51 940147 1176 69987070
Mass 23.54 11.57 320 939878 15706 69972540
Linear IgA disease 23.52 11.57 5 940193 2919 69985327
Immunosuppressant drug level increased 23.50 11.57 43 940155 7864 69980382
Nystagmus 23.49 11.57 56 940142 9299 69978947
Bone marrow oedema 23.49 11.57 56 940142 1379 69986867
Discouragement 23.48 11.57 54 940144 1298 69986948
Intertrigo 23.39 11.57 36 940162 631 69987615
Cartilage atrophy 23.37 11.57 19 940179 155 69988091
Thyroid cancer 23.37 11.57 132 940066 5013 69983233
Osteophyte fracture 23.36 11.57 7 940191 0 69988246
Heavy chain disease 23.36 11.57 7 940191 0 69988246
Anticipatory anxiety 23.32 11.57 45 940153 953 69987293
Protein urine present 23.32 11.57 57 940141 9383 69978863
Red blood cells urine positive 23.31 11.57 17 940181 4692 69983554
Anticoagulation drug level above therapeutic 23.23 11.57 7 940191 3231 69985015
Infusion site pruritus 23.22 11.57 7 940191 3230 69985016
Ileal stenosis 23.21 11.57 72 940126 2079 69986167
Radiation pneumonitis 23.07 11.57 10 940188 3683 69984563
Antibody test positive 23.07 11.57 80 940118 2451 69985795
Sleep disorder due to a general medical condition 23.04 11.57 67 940131 10409 69977837
Pancreatitis 23.03 11.57 643 939555 62025 69926221
Anion gap increased 22.98 11.57 7 940191 3209 69985037
Serum procollagen type III N-terminal propeptide increased 22.97 11.57 12 940186 40 69988206
Immune effector cell-associated neurotoxicity syndrome 22.97 11.57 12 940186 3966 69984280
Syringe issue 22.97 11.57 22 940176 5306 69982940
Human herpesvirus 6 infection 22.96 11.57 126 940072 4733 69983513
Hyperparathyroidism 22.95 11.57 6 940192 3041 69985205
Blood urine present 22.95 11.57 156 940042 19197 69969049
Pregnancy 22.90 11.57 203 939995 23578 69964668
Lacunar infarction 22.87 11.57 25 940173 5671 69982575
Hepatosplenomegaly 22.87 11.57 141 940057 5529 69982717
Focal segmental glomerulosclerosis 22.85 11.57 7 940191 3197 69985049
Trigger finger 22.82 11.57 104 940094 3623 69984623
Polyomavirus-associated nephropathy 22.81 11.57 21 940177 5162 69983084
Cystitis 22.79 11.57 798 939400 46143 69942103
Anticonvulsant drug level increased 22.76 11.57 3 940195 2483 69985763
Cytopenia 22.69 11.57 339 939859 16984 69971262
Inflammatory bowel disease 22.62 11.57 129 940069 4917 69983329
Anaemia macrocytic 22.59 11.57 131 940067 5024 69983222
Paraplegia 22.58 11.57 123 940075 4607 69983639
Exposure to communicable disease 22.55 11.57 31 940167 488 69987758
Tearfulness 22.50 11.57 20 940178 5000 69983246
Hypertonia 22.45 11.57 32 940166 6466 69981780
Middle lobe syndrome 22.38 11.57 11 940187 31 69988215
Post transplant lymphoproliferative disorder 22.37 11.57 226 939972 10319 69977927
Viral infection 22.36 11.57 667 939531 37724 69950522
Vasoplegia syndrome 22.32 11.57 7 940191 3149 69985097
Infusion site haemorrhage 22.27 11.57 5 940193 2810 69985436
Purpura 22.26 11.57 143 940055 17832 69970414
Bursitis infective staphylococcal 22.25 11.57 14 940184 72 69988174
Scleroderma renal crisis 22.22 11.57 28 940170 403 69987843
Pachymeningitis 22.19 11.57 23 940175 264 69987982
Mucosal necrosis 22.17 11.57 16 940182 107 69988139
Pneumonitis 22.17 11.57 910 939288 53687 69934559
Tooth disorder 22.14 11.57 443 939755 23495 69964751
Red blood cell sedimentation rate decreased 22.11 11.57 21 940177 215 69988031
Benign prostatic hyperplasia 22.09 11.57 68 940130 10375 69977871
Osteosarcoma metastatic 22.07 11.57 13 940185 58 69988188
Cytology abnormal 22.04 11.57 25 940173 320 69987926
Tender joint count increased 22.03 11.57 18 940180 148 69988098
Tongue ulceration 22.02 11.57 103 940095 3628 69984618
Sexual dysfunction 22.01 11.57 34 940164 6647 69981599
Mycobacterium avium complex infection 21.94 11.57 114 940084 4192 69984054
Hot flush 21.93 11.57 495 939703 49089 69939157
Metabolic disorder 21.93 11.57 46 940152 7994 69980252
Muscular weakness 21.90 11.57 1558 938640 136778 69851468
Lip oedema 21.88 11.57 25 940173 5558 69982688
Meningitis aseptic 21.86 11.57 153 940045 6266 69981980
Angle closure glaucoma 21.85 11.57 5 940193 2774 69985472
Blood glucose abnormal 21.85 11.57 60 940138 9497 69978749
Catheter site erythema 21.84 11.57 20 940178 4928 69983318
Ependymoma malignant 21.77 11.57 9 940189 14 69988232
Eructation 21.77 11.57 62 940136 9698 69978548
Stress 21.77 11.57 1106 939092 66860 69921386
Thrombotic thrombocytopenic purpura 21.76 11.57 30 940168 6147 69982099
Rheumatoid arthritis-associated interstitial lung disease 21.76 11.57 8 940190 7 69988239
Protein total decreased 21.73 11.57 48 940150 8188 69980058
Cholesteatoma 21.71 11.57 16 940182 111 69988135
Hair follicle tumour benign 21.71 11.57 28 940170 413 69987833
Post-traumatic stress disorder 21.70 11.57 16 940182 4391 69983855
Oesophageal squamous cell carcinoma 21.69 11.57 30 940168 475 69987771
Blood calcium increased 21.67 11.57 55 940143 8938 69979308
Tibia fracture 21.66 11.57 125 940073 4785 69983461
Eczema 21.65 11.57 316 939882 33465 69954781
Meniscus injury 21.60 11.57 148 940050 6019 69982227
Small intestinal haemorrhage 21.53 11.57 13 940185 3965 69984281
Aortic stenosis 21.48 11.57 34 940164 6582 69981664
Procedural pain 21.43 11.57 145 940053 17864 69970382
Pulmonary nocardiosis 21.38 11.57 40 940158 827 69987419
Encephalitis brain stem 21.35 11.57 20 940178 201 69988045
Foetal exposure during pregnancy 21.35 11.57 26 940172 5619 69982627
Product prescribing issue 21.31 11.57 7 940191 3057 69985189
Growth failure 21.30 11.57 21 940177 226 69988020
Bradyarrhythmia 21.28 11.57 13 940185 3940 69984306
Rheumatoid factor 21.27 11.57 16 940182 115 69988131
Solar urticaria 21.26 11.57 13 940185 63 69988183
Hypoventilation 21.21 11.57 34 940164 6548 69981698
Haemorrhagic transformation stroke 21.16 11.57 4 940194 2537 69985709
Haematopoietic neoplasm 21.11 11.57 14 940184 80 69988166
Sweat gland tumour 21.10 11.57 30 940168 488 69987758
Psoriasis area severity index increased 21.06 11.57 15 940183 98 69988148
Apnoea 21.06 11.57 73 940125 10736 69977510
Cerebrosclerosis 21.05 11.57 9 940189 16 69988230
Diverticular perforation 21.04 11.57 135 940063 5369 69982877
Procedural haemorrhage 21.00 11.57 17 940181 4450 69983796
Fanconi syndrome acquired 21.00 11.57 4 940194 2523 69985723
Dermatitis psoriasiform 20.99 11.57 73 940125 2240 69986006
Neck deformity 20.94 11.57 61 940137 1700 69986546
Steroid dependence 20.93 11.57 35 940163 660 69987586
Nasopharyngeal cancer 20.91 11.57 19 940179 183 69988063
Euphoric mood 20.89 11.57 37 940161 6852 69981394
Catheter site pain 20.85 11.57 21 940177 4947 69983299
Stress fracture 20.85 11.57 141 940057 5709 69982537
Spondylitis 20.82 11.57 96 940102 3361 69984885
Double stranded DNA antibody positive 20.80 11.57 27 940171 401 69987845
Antithrombin III decreased 20.78 11.57 28 940170 432 69987814
Blood thyroid stimulating hormone decreased 20.75 11.57 25 940173 5429 69982817
Crystal nephropathy 20.75 11.57 50 940148 1240 69987006
Myositis 20.72 11.57 141 940057 17348 69970898
Acute myelomonocytic leukaemia 20.72 11.57 23 940175 287 69987959
Cardiac murmur 20.70 11.57 87 940111 12099 69976147
Tender joint count 20.64 11.57 13 940185 67 69988179
Localised oedema 20.63 11.57 42 940156 7379 69980867
Infiltration anaesthesia 20.60 11.57 17 940181 142 69988104
Generalised oedema 20.60 11.57 186 940012 21522 69966724
Psychomotor skills impaired 20.52 11.57 16 940182 4268 69983978
Hyperthermia malignant 20.51 11.57 5 940193 2656 69985590
Sinus congestion 20.48 11.57 334 939864 17039 69971207
Meningitis noninfective 20.47 11.57 12 940186 53 69988193
Electrocardiogram T wave abnormal 20.45 11.57 10 940188 3432 69984814
Nephrolithiasis 20.43 11.57 794 939404 46529 69941717
Ocular hypertension 20.43 11.57 52 940146 1336 69986910
Breast abscess 20.39 11.57 49 940149 1213 69987033
Actinomycotic pulmonary infection 20.39 11.57 10 940188 28 69988218
Tumour haemorrhage 20.37 11.57 12 940186 3710 69984536
Prosthesis user 20.35 11.57 13 940185 69 69988177
CSF myelin basic protein increased 20.34 11.57 8 940190 10 69988236
Micturition urgency 20.34 11.57 79 940119 11235 69977011
Laryngitis fungal 20.32 11.57 16 940182 124 69988122
Eyelid oedema 20.32 11.57 93 940105 12634 69975612
Paradoxical psoriasis 20.28 11.57 19 940179 191 69988055
Accidental exposure to product by child 20.25 11.57 6 940192 2800 69985446
Major depression 20.22 11.57 53 940145 8521 69979725
Exercise tolerance decreased 20.22 11.57 50 940148 8198 69980048
Tongue neoplasm malignant stage unspecified 20.19 11.57 43 940155 980 69987266
Eye infection toxoplasmal 20.15 11.57 30 940168 510 69987736
Application site erythema 20.13 11.57 20 940178 4741 69983505
Troponin I increased 20.12 11.57 15 940183 4093 69984153
Eye infection 20.11 11.57 214 939984 9904 69978342
Capnocytophaga infection 20.06 11.57 13 940185 71 69988175
Kidney infection 20.03 11.57 366 939832 19089 69969157
Arthritis viral 20.02 11.57 6 940192 0 69988246
Foetal methotrexate syndrome 20.02 11.57 6 940192 0 69988246
Adactyly 20.02 11.57 6 940192 0 69988246
Oropharyngeal discolouration 20.02 11.57 6 940192 0 69988246
Ischaemia 19.99 11.57 44 940154 7515 69980731
Supraventricular extrasystoles 19.99 11.57 32 940166 6166 69982080
Cerebral venous thrombosis 19.97 11.57 76 940122 2439 69985807
Stomatitis haemorrhagic 19.95 11.57 14 940184 89 69988157
Pyomyositis 19.95 11.57 31 940167 548 69987698
Haemolysis 19.91 11.57 82 940116 11469 69976777
Loose body in joint 19.91 11.57 49 940149 1232 69987014
Spinal fusion surgery 19.80 11.57 105 940093 3892 69984354
Distributive shock 19.78 11.57 3 940195 2234 69986012
Cytomegalovirus test positive 19.78 11.57 133 940065 5375 69982871
Breath sounds abnormal 19.77 11.57 99 940099 13132 69975114
Hidradenitis 19.76 11.57 86 940112 2936 69985310
Red blood cell sedimentation rate 19.74 11.57 122 940076 4788 69983458
Salivary gland cancer 19.73 11.57 27 940171 423 69987823
Blood lactate dehydrogenase increased 19.68 11.57 337 939861 34790 69953456
Arterial haemorrhage 19.65 11.57 4 940194 2407 69985839
Fusarium infection 19.65 11.57 59 940139 1673 69986573
Progressive multifocal leukoencephalopathy 19.62 11.57 361 939837 18853 69969393
Cell-mediated immune deficiency 19.59 11.57 14 940184 92 69988154
Laryngospasm 19.58 11.57 12 940186 3631 69984615
Sinus node dysfunction 19.57 11.57 41 940157 7128 69981118
Therapy partial responder 19.54 11.57 252 939946 12222 69976024
Overlap syndrome 19.52 11.57 36 940162 736 69987510
Polychondritis 19.44 11.57 30 940168 527 69987719
Refractoriness to platelet transfusion 19.35 11.57 16 940182 134 69988112
Tongue neoplasm 19.33 11.57 12 940186 60 69988186
SAPHO syndrome 19.31 11.57 19 940179 204 69988042
Transplant dysfunction 19.29 11.57 39 940159 6870 69981376
Coagulopathy 19.28 11.57 317 939881 32932 69955314
Listeriosis 19.20 11.57 65 940133 1967 69986279
Empyema 19.18 11.57 102 940096 3785 69984461
Idiopathic pneumonia syndrome 19.12 11.57 30 940168 535 69987711
Intervertebral discitis 19.06 11.57 107 940091 4054 69984192
Malignant neoplasm of conjunctiva 19.04 11.57 11 940187 47 69988199
Pseudomonas test positive 19.04 11.57 58 940140 1658 69986588
Cardiac pacemaker insertion 19.01 11.57 26 940172 5346 69982900
Ankle arthroplasty 19.01 11.57 46 940152 1144 69987102
Catheter site pruritus 19.00 11.57 3 940195 2168 69986078
Psychiatric symptom 18.99 11.57 37 940161 6607 69981639
Product preparation error 18.93 11.57 19 940179 4483 69983763
Metastatic bronchial carcinoma 18.92 11.57 21 940177 262 69987984
Wernicke's encephalopathy 18.92 11.57 9 940189 23 69988223
Malignant respiratory tract neoplasm 18.92 11.57 9 940189 23 69988223
Splenic infection fungal 18.90 11.57 14 940184 98 69988148
Human bocavirus infection 18.90 11.57 31 940167 575 69987671
Thymus enlargement 18.88 11.57 15 940183 118 69988128
Injection site hypersensitivity 18.83 11.57 59 940139 1713 69986533
Renal artery stenosis 18.82 11.57 10 940188 3274 69984972
Hypersomnia 18.80 11.57 180 940018 20584 69967662
Ecchymosis 18.80 11.57 112 940086 14220 69974026
Cell marker increased 18.75 11.57 32 940166 614 69987632
Bipolar disorder 18.74 11.57 46 940152 7562 69980684
Orthopnoea 18.69 11.57 63 940135 9345 69978901
Plasma cell myeloma recurrent 18.67 11.57 18 940180 4328 69983918
Leukodystrophy 18.65 11.57 9 940189 24 69988222
Precursor T-lymphoblastic lymphoma/leukaemia 18.58 11.57 15 940183 121 69988125
Subcutaneous abscess 18.57 11.57 163 940035 7159 69981087
Glioblastoma multiforme 18.55 11.57 48 940150 1246 69987000
Pain of skin 18.52 11.57 213 939985 10053 69978193
Haemoperitoneum 18.51 11.57 16 940182 4055 69984191
Hepatitis C 18.48 11.57 97 940101 12710 69975536
Device physical property issue 18.47 11.57 4 940194 2305 69985941
Hepatic cancer 18.46 11.57 66 940132 9617 69978629
Self-medication 18.40 11.57 19 940179 4424 69983822
Acanthosis 18.39 11.57 27 940171 453 69987793
Guttate psoriasis 18.38 11.57 26 940172 421 69987825
Oesophageal stenosis 18.37 11.57 103 940095 3901 69984345
Hair colour changes 18.35 11.57 15 940183 3908 69984338
Local reaction 18.33 11.57 29 940169 521 69987725
Scab 18.31 11.57 200 939998 9318 69978928
Acute psychosis 18.29 11.57 15 940183 3901 69984345
Surgery 18.28 11.57 524 939674 29465 69958781
Diffuse large B-cell lymphoma stage II 18.25 11.57 14 940184 104 69988142
Atrial thrombosis 18.22 11.57 10 940188 3215 69985031
Injection site vesicles 18.20 11.57 79 940119 2694 69985552
Medical device site joint infection 18.18 11.57 20 940178 247 69987999
Diabetic nephropathy 18.15 11.57 7 940191 2766 69985480
Catheter site discharge 18.10 11.57 4 940194 2273 69985973
Cystic fibrosis 18.08 11.57 18 940180 4263 69983983
Anal fissure 18.07 11.57 143 940055 6090 69982156
Autoimmune lymphoproliferative syndrome 18.06 11.57 17 940181 172 69988074
Gingivitis ulcerative 18.05 11.57 20 940178 249 69987997
Feeling jittery 18.05 11.57 85 940113 11458 69976788
Encephalopathy 18.00 11.57 652 939546 61009 69927237
Pertussis 17.99 11.57 37 940161 822 69987424
Suicidal behaviour 17.97 11.57 9 940189 3047 69985199
Diarrhoea haemorrhagic 17.97 11.57 236 939962 11494 69976752
Flank pain 17.93 11.57 147 940051 17355 69970891
Disseminated sporotrichosis 17.91 11.57 9 940189 27 69988219
Brachiocephalic artery stenosis 17.91 11.57 9 940189 27 69988219
Osteonecrosis 17.91 11.57 510 939688 28650 69959596
Device malfunction 17.90 11.57 164 940034 18920 69969326
Vascular purpura 17.86 11.57 7 940191 2739 69985507
Quadriplegia 17.85 11.57 85 940113 3017 69985229
Weight increased 17.83 11.57 3556 936642 238775 69749471
Anal inflammation 17.83 11.57 29 940169 534 69987712
Gynaecomastia 17.81 11.57 40 940158 6783 69981463
Electrocardiogram ST segment depression 17.72 11.57 20 940178 4471 69983775
Device use issue 17.70 11.57 4 940194 2238 69986008
Skin neoplasm excision 17.68 11.57 39 940159 911 69987335
Cervical dysplasia 17.62 11.57 62 940136 1914 69986332
Wheelchair user 17.60 11.57 124 940074 5090 69983156
Cystitis viral 17.56 11.57 32 940166 648 69987598
Large intestine anastomosis 17.55 11.57 13 940185 91 69988155
Cerebellar haemorrhage 17.53 11.57 7 940191 2708 69985538
Papulopustular rosacea 17.50 11.57 8 940190 18 69988228
Synovial rupture 17.49 11.57 22 940176 316 69987930
Squamous cell carcinoma of the oral cavity 17.47 11.57 27 940171 475 69987771
Subdural hygroma 17.46 11.57 26 940172 442 69987804
Peritonsillar abscess 17.41 11.57 36 940162 803 69987443
Pityriasis rubra pilaris 17.34 11.57 14 940184 113 69988133
Therapy interrupted 17.32 11.57 228 939970 24574 69963672
Intra-abdominal haematoma 17.28 11.57 7 940191 2685 69985561
Skin infection 17.26 11.57 305 939893 15807 69972439
Graft versus host disease in eye 17.26 11.57 21 940177 291 69987955
Schizoaffective disorder 17.25 11.57 3 940195 2020 69986226
Dermatitis allergic 17.23 11.57 310 939888 16121 69972125
Oesophageal varices haemorrhage 17.23 11.57 15 940183 3788 69984458
Tendon rupture 17.23 11.57 225 939973 10944 69977302
Hypertension 17.22 11.57 3563 936635 292470 69695776
Bronchiolitis obliterans syndrome 17.17 11.57 20 940178 264 69987982
Frequent bowel movements 17.15 11.57 384 939814 20769 69967477
Peripheral coldness 17.13 11.57 117 940081 14383 69973863
Squamous cell carcinoma of the tongue 17.12 11.57 32 940166 661 69987585
Pupillary reflex impaired 17.10 11.57 11 940187 3243 69985003
Catheter site infection 17.10 11.57 34 940164 6026 69982220
Snoring 17.09 11.57 24 940174 4880 69983366
Application site rash 17.08 11.57 3 940195 2006 69986240
Antisynthetase syndrome 17.06 11.57 16 940182 161 69988085
Lymphocyte percentage decreased 17.05 11.57 23 940175 4756 69983490
Pulmonary granuloma 17.02 11.57 60 940138 1854 69986392
Galactorrhoea 16.98 11.57 12 940186 3366 69984880
Urticarial vasculitis 16.97 11.57 29 940169 557 69987689
Lower respiratory tract infection viral 16.97 11.57 42 940156 1060 69987186
Endocarditis bacterial 16.94 11.57 50 940148 1404 69986842
Pterygium 16.94 11.57 21 940177 297 69987949
Intraventricular haemorrhage 16.93 11.57 20 940178 4381 69983865
Genital abscess 16.91 11.57 16 940182 163 69988083
Ulcerative keratitis 16.90 11.57 88 940110 3239 69985007
Immune recovery uveitis 16.89 11.57 7 940191 11 69988235
Injection site induration 16.89 11.57 191 940007 8977 69979269
Endometrial adenocarcinoma 16.86 11.57 40 940158 982 69987264
Steatohepatitis 16.83 11.57 35 940163 784 69987462
Liver transplant 16.83 11.57 19 940179 4247 69983999
Pathogen resistance 16.78 11.57 105 940093 13174 69975072
Perineal necrosis 16.77 11.57 14 940184 119 69988127
Growth retardation 16.76 11.57 55 940143 1637 69986609
Petit mal epilepsy 16.73 11.57 29 940169 5415 69982831
Bladder transitional cell carcinoma 16.72 11.57 72 940126 2447 69985799
Multiple organ dysfunction syndrome 16.71 11.57 1225 938973 107290 69880956
Haemarthrosis 16.69 11.57 29 940169 5410 69982836
Acute monocytic leukaemia 16.68 11.57 27 940171 495 69987751
Rotator cuff repair 16.66 11.57 54 940144 1597 69986649
Osteosarcoma recurrent 16.58 11.57 10 940188 47 69988199
Chromosomal deletion 16.54 11.57 12 940186 81 69988165
Femoroacetabular impingement 16.53 11.57 7 940191 12 69988234
Intussusception 16.51 11.57 38 940160 914 69987332
Product taste abnormal 16.49 11.57 4 940194 2132 69986114
Extremity contracture 16.48 11.57 54 940144 1606 69986640
Vasculitis 16.47 11.57 357 939841 19201 69969045
Blau syndrome 16.45 11.57 6 940192 5 69988241
Occult blood positive 16.41 11.57 38 940160 6375 69981871
Anaplastic large cell lymphoma T- and null-cell types 16.39 11.57 16 940182 170 69988076
Tuberculosis of central nervous system 16.38 11.57 28 940170 538 69987708
Concomitant disease progression 16.37 11.57 12 940186 3303 69984943
Diabetic retinopathy 16.34 11.57 9 940189 2888 69985358
Pneumocystis jirovecii infection 16.34 11.57 73 940125 2521 69985725
Infusion site extravasation 16.34 11.57 53 940145 7955 69980291
Furuncle 16.33 11.57 153 940045 6845 69981401
Hepatitis B 16.31 11.57 172 940026 7942 69980304
Ventricular hypokinesia 16.31 11.57 55 940143 8157 69980089
Pneumonia viral 16.31 11.57 175 940023 8117 69980129
Sinusitis bacterial 16.28 11.57 47 940151 1303 69986943
Pseudopolyp 16.25 11.57 24 940174 405 69987841
Bone marrow transplant rejection 16.24 11.57 19 940179 252 69987994
Rotator cuff syndrome 16.21 11.57 248 939950 12486 69975760
Gliosis 16.20 11.57 24 940174 406 69987840
Dysstasia 16.20 11.57 443 939755 24736 69963510
Tachyarrhythmia 16.19 11.57 38 940160 6344 69981902
Device alarm issue 16.15 11.57 3 940195 1927 69986319
Staphylococcal sepsis 16.15 11.57 259 939939 13168 69975078
Essential hypertension 16.14 11.57 30 940168 5454 69982792
Subcutaneous haematoma 16.09 11.57 7 940191 2572 69985674
Hydronephrosis 16.08 11.57 127 940071 15115 69973131
Bronchial secretion retention 16.06 11.57 10 940188 3000 69985246
Plasmacytoma 16.05 11.57 18 940180 4036 69984210
Injection site papule 16.05 11.57 35 940163 811 69987435
Bone abscess 16.05 11.57 25 940173 443 69987803
Precancerous cells present 16.04 11.57 41 940157 1056 69987190
Abdominal pain lower 16.04 11.57 270 939928 27946 69960300
Neutrophilia 16.01 11.57 46 940152 7175 69981071
Hiatus hernia 15.99 11.57 191 940007 20943 69967303
Unintended pregnancy 15.96 11.57 12 940186 3261 69984985
Walking aid user 15.96 11.57 169 940029 7812 69980434
Terminal ileitis 15.96 11.57 31 940167 660 69987586
Nasal mucosal ulcer 15.94 11.57 6 940192 6 69988240
Myxoid liposarcoma 15.94 11.57 6 940192 6 69988240
Tendon graft 15.94 11.57 6 940192 6 69988240
Prostate cancer stage IV 15.87 11.57 5 940193 2243 69986003
Facial paralysis 15.87 11.57 359 939839 19449 69968797
Mycotic allergy 15.87 11.57 41 940157 1063 69987183
Rhonchi 15.86 11.57 15 940183 3640 69984606
Nodal arrhythmia 15.84 11.57 3 940195 1900 69986346
Androgenetic alopecia 15.84 11.57 15 940183 153 69988093
Bronchioloalveolar carcinoma 15.81 11.57 10 940188 52 69988194
Facial paresis 15.80 11.57 118 940080 4935 69983311
Contraindication to vaccination 15.76 11.57 17 940181 205 69988041
Vaginal haemorrhage 15.76 11.57 183 940015 20169 69968077
Perirectal abscess 15.74 11.57 58 940140 1832 69986414
Injection site discomfort 15.73 11.57 111 940087 4558 69983688
Differential white blood cell count abnormal 15.66 11.57 3 940195 1885 69986361
Inflammatory pseudotumour 15.66 11.57 10 940188 53 69988193
Food allergy 15.66 11.57 59 940139 8465 69979781
Meningitis enterococcal 15.66 11.57 12 940186 89 69988157
Stem cell transplant 15.64 11.57 91 940107 3494 69984752
Blood parathyroid hormone increased 15.62 11.57 12 940186 3225 69985021
Blood uric acid increased 15.62 11.57 65 940133 9064 69979182
Soft tissue swelling 15.58 11.57 43 940155 1161 69987085
Blood chloride increased 15.57 11.57 26 940172 4927 69983319
Rash erythematous 15.52 11.57 545 939653 51173 69937073
Gastrointestinal sounds abnormal 15.51 11.57 27 940171 5034 69983212
PO2 decreased 15.51 11.57 9 940189 2805 69985441
Cardiac valve disease 15.48 11.57 30 940168 5368 69982878
Deafness neurosensory 15.47 11.57 145 940053 6487 69981759
Lip and/or oral cavity cancer 15.45 11.57 36 940162 873 69987373
Infectious thyroiditis 15.44 11.57 13 940185 112 69988134
Feeling cold 15.42 11.57 242 939956 25328 69962918
Disease susceptibility 15.41 11.57 20 940178 297 69987949
Gastritis erosive 15.39 11.57 75 940123 10020 69978226
Economic problem 15.39 11.57 5 940193 2199 69986047
Fracture delayed union 15.35 11.57 61 940137 1998 69986248
Parakeratosis 15.34 11.57 22 940176 361 69987885
Peritonitis 15.30 11.57 249 939949 25910 69962336
Renal disorder 15.28 11.57 385 939813 37624 69950622
Night sweats 15.27 11.57 717 939481 42967 69945279
Peripheral T-cell lymphoma unspecified 15.25 11.57 34 940164 800 69987446
Peripheral vascular disorder 15.24 11.57 51 940147 7581 69980665
Oligoarthritis 15.23 11.57 26 940172 499 69987747
Loss of libido 15.22 11.57 7 940191 2490 69985756
Nodular melanoma 15.18 11.57 15 940183 162 69988084
Shoulder operation 15.17 11.57 68 940130 2352 69985894
Myelomalacia 15.17 11.57 13 940185 115 69988131
Pleural thickening 15.15 11.57 76 940122 2756 69985490
Diplopia 15.14 11.57 272 939926 27875 69960371
Spinal meningioma benign 15.14 11.57 12 940186 94 69988152
Resuscitation 15.13 11.57 6 940192 2331 69985915
Pain in jaw 15.12 11.57 440 939758 42229 69946017
Alcohol withdrawal syndrome 15.12 11.57 3 940195 1838 69986408
Skin atrophy 15.11 11.57 119 940079 5060 69983186
Hypopituitarism 15.11 11.57 11 940187 3039 69985207
Inflammatory myofibroblastic tumour 15.10 11.57 15 940183 163 69988083
Vasculitic rash 15.09 11.57 60 940138 1966 69986280
Drug-device interaction 15.08 11.57 11 940187 75 69988171
Neutrophil percentage increased 15.08 11.57 23 940175 4519 69983727
Scarlet fever 15.04 11.57 12 940186 95 69988151
Atrial septal defect acquired 15.04 11.57 6 940192 8 69988238
Presbyacusis 14.98 11.57 72 940126 2565 69985681
Hypermobility syndrome 14.98 11.57 26 940172 506 69987740
Incision site pain 14.97 11.57 9 940189 2752 69985494
Meningitis coccidioides 14.97 11.57 10 940188 58 69988188
Ear infection bacterial 14.95 11.57 12 940186 96 69988150
Norovirus test positive 14.93 11.57 25 940173 472 69987774
Bronchiectasis 14.92 11.57 298 939900 15799 69972447
Bladder transitional cell carcinoma recurrent 14.92 11.57 14 940184 141 69988105
Infusion site reaction 14.92 11.57 75 940123 2722 69985524
Purulent discharge 14.89 11.57 127 940071 5531 69982715
Hypertensive emergency 14.87 11.57 7 940191 2456 69985790
Persecutory delusion 14.87 11.57 23 940175 4494 69983752
Cytogenetic abnormality 14.87 11.57 39 940159 1021 69987225
HLA-B*27 positive 14.85 11.57 12 940186 97 69988149
Hyperphosphataemia 14.83 11.57 21 940177 4255 69983991
Cholangitis 14.76 11.57 91 940107 11458 69976788
Tension 14.73 11.57 19 940179 4005 69984241
Feeling abnormal 14.72 11.57 1656 938542 140663 69847583
Pneumonitis chemical 14.71 11.57 21 940177 343 69987903
Vaginal infection 14.71 11.57 120 940078 5158 69983088
Familial haemophagocytic lymphohistiocytosis 14.70 11.57 10 940188 60 69988186
T-cell lymphoma refractory 14.70 11.57 10 940188 60 69988186
Tic 14.70 11.57 9 940189 2724 69985522
Premature rupture of membranes 14.69 11.57 18 940180 3880 69984366
Metatarsalgia 14.67 11.57 17 940181 223 69988023
Fistula 14.67 11.57 214 939984 10667 69977579
Vitreous floaters 14.65 11.57 43 940155 6661 69981585
Respiratory tract infection 14.63 11.57 695 939503 41703 69946543
Hepatic candidiasis 14.63 11.57 11 940187 79 69988167
Torus fracture 14.63 11.57 11 940187 79 69988167
Dyslipidaemia 14.61 11.57 74 940124 9786 69978460
Sluggishness 14.59 11.57 36 940162 5907 69982339
Tinea versicolour 14.59 11.57 20 940178 314 69987932
Pyopneumothorax 14.57 11.57 10 940188 61 69988185
Purulent pericarditis 14.57 11.57 10 940188 61 69988185
Combined immunodeficiency 14.56 11.57 12 940186 100 69988146
Leukoerythroblastosis 14.55 11.57 18 940180 254 69987992
Cytomegalovirus hepatitis 14.54 11.57 31 940167 707 69987539
Retinal pigment epitheliopathy 14.52 11.57 22 940176 380 69987866
Graft versus host disease in lung 14.52 11.57 33 940165 787 69987459
Carotid artery stenosis 14.49 11.57 58 940140 8178 69980068
Anal incontinence 14.49 11.57 144 940054 16346 69971900
Anovulatory cycle 14.49 11.57 13 940185 123 69988123
Appetite disorder 14.48 11.57 46 940152 6949 69981297
Oesophagitis 14.48 11.57 212 939986 22440 69965806
Cardiovascular disorder 14.47 11.57 146 940052 16524 69971722
Brain injury 14.44 11.57 82 940116 10535 69977711
Endotracheal intubation 14.43 11.57 22 940176 4324 69983922
Venous injury 14.42 11.57 30 940168 672 69987574
Laryngitis viral 14.42 11.57 7 940191 19 69988227
Arthroscopy 14.42 11.57 25 940173 486 69987760
Cervix carcinoma stage 0 14.39 11.57 17 940181 228 69988018
Respiratory tract ulceration 14.37 11.57 5 940193 3 69988243
Aspergillus infection 14.37 11.57 324 939874 17544 69970702
Subacute combined cord degeneration 14.36 11.57 20 940178 319 69987927
Blood creatine phosphokinase MB increased 14.34 11.57 9 940189 2688 69985558
Lymphoedema 14.27 11.57 88 940110 11081 69977165
Glottis carcinoma 14.27 11.57 6 940192 10 69988236
Malignant melanoma stage I 14.24 11.57 13 940185 126 69988120
Blood fibrinogen decreased 14.24 11.57 54 940144 1730 69986516
Squamous cell carcinoma of the cervix 14.21 11.57 16 940182 203 69988043
Biliary dyskinesia 14.21 11.57 7 940191 2392 69985854
Ejection fraction 14.20 11.57 3 940195 1759 69986487
Knee operation 14.20 11.57 115 940083 4932 69983314
Dyspnoea paroxysmal nocturnal 14.18 11.57 5 940193 2088 69986158
Urine output increased 14.17 11.57 4 940194 1927 69986319
Pancreatic calcification 14.17 11.57 17 940181 232 69988014
Perineal infection 14.11 11.57 31 940167 722 69987524
Ligament calcification 14.09 11.57 16 940182 205 69988041
Heavy menstrual bleeding 14.08 11.57 104 940094 12561 69975685
Limb mass 14.05 11.57 84 940114 3258 69984988
Oesophageal carcinoma 14.04 11.57 70 940128 9296 69978950
Retroperitoneal haematoma 14.04 11.57 28 940170 4957 69983289
Strongyloidiasis 14.04 11.57 91 940107 3632 69984614
Intestinal polyp 14.01 11.57 57 940141 1888 69986358
Diabetic neuropathy 13.98 11.57 36 940162 5822 69982424
Infected bite 13.96 11.57 50 940148 1557 69986689
Femur fracture 13.93 11.57 599 939599 35533 69952713
Muscle swelling 13.89 11.57 32 940166 770 69987476
Induced abortion failed 13.83 11.57 15 940183 182 69988064
Vulval cancer 13.83 11.57 24 940174 467 69987779
Nausea 13.82 11.57 10744 929454 841344 69146902
Thyroiditis 13.82 11.57 20 940178 4016 69984230
Hepatitis fulminant 13.82 11.57 43 940155 6538 69981708
Cauda equina syndrome 13.80 11.57 42 940156 1200 69987046
Intestinal malrotation 13.80 11.57 5 940193 4 69988242
Congenital foot malformation 13.80 11.57 5 940193 4 69988242
Exposed bone in jaw 13.79 11.57 16 940182 3533 69984713
Post transplant distal limb syndrome 13.78 11.57 26 940172 541 69987705
Psychogenic seizure 13.78 11.57 4 940194 1892 69986354
Elbow operation 13.78 11.57 19 940179 300 69987946
Medulloblastoma recurrent 13.77 11.57 13 940185 132 69988114
Breast mass 13.76 11.57 127 940071 5658 69982588
Internal haemorrhage 13.75 11.57 58 940140 8058 69980188
Incorrect dosage administered 13.72 11.57 65 940133 2302 69985944
Colitis microscopic 13.72 11.57 181 940017 8824 69979422
Hypopnoea 13.70 11.57 15 940183 3400 69984846
Follicular lymphoma 13.68 11.57 18 940180 271 69987975
Tongue disorder 13.68 11.57 249 939949 12978 69975268
Aortic valve incompetence 13.67 11.57 66 940132 8838 69979408
Cheilitis 13.65 11.57 111 940087 4766 69983480
Erythema nodosum 13.65 11.57 104 940094 4377 69983869
Infection reactivation 13.63 11.57 65 940133 2308 69985938
Leptotrichia infection 13.63 11.57 9 940189 51 69988195
Liver sarcoidosis 13.59 11.57 6 940192 12 69988234
Affective disorder 13.59 11.57 52 940146 7427 69980819
Joint surgery 13.58 11.57 18 940180 273 69987973
Pericarditis tuberculous 13.58 11.57 12 940186 111 69988135
Red cell distribution width decreased 13.58 11.57 50 940148 1579 69986667
Device infusion issue 13.57 11.57 4 940194 1873 69986373
Hepatic cytolysis 13.56 11.57 176 940022 19016 69969230
Mood swings 13.55 11.57 166 940032 18120 69970126
Erythema induratum 13.52 11.57 15 940183 187 69988059
Mucosal infection 13.52 11.57 23 940175 440 69987806
Middle insomnia 13.51 11.57 120 940078 13933 69974313
Histiocytic sarcoma 13.50 11.57 12 940186 112 69988134
Nasal cavity cancer 13.46 11.57 16 940182 216 69988030
Candida test positive 13.46 11.57 38 940160 1040 69987206
Polycystic ovaries 13.41 11.57 11 940187 2861 69985385
Acquired claw toe 13.41 11.57 11 940187 91 69988155
Alopecia universalis 13.40 11.57 15 940183 189 69988057
Postoperative wound infection 13.37 11.57 218 939980 11120 69977126
Cutaneous T-cell lymphoma stage II 13.37 11.57 8 940190 37 69988209
Overwork 13.36 11.57 9 940189 53 69988193
Peripheral T-cell lymphoma unspecified stage II 13.35 11.57 4 940194 0 69988246
Oral toxicity 13.35 11.57 4 940194 0 69988246
Myocarditis bacterial 13.35 11.57 4 940194 0 69988246
Mucinous breast carcinoma 13.35 11.57 4 940194 0 69988246
Herpes ophthalmic 13.35 11.57 44 940154 1313 69986933
Leukaemia monocytic 13.35 11.57 4 940194 0 69988246
Necrotising fasciitis staphylococcal 13.35 11.57 4 940194 0 69988246
Respiratory rate decreased 13.35 11.57 27 940171 4755 69983491
Paranasal sinus hypersecretion 13.33 11.57 83 940115 3266 69984980
Blood testosterone decreased 13.32 11.57 7 940191 2306 69985940
Demyelinating polyneuropathy 13.29 11.57 49 940149 1548 69986698
Spinal rod insertion 13.28 11.57 5 940193 5 69988241
Bladder neck operation 13.28 11.57 5 940193 5 69988241
Desmoid tumour 13.28 11.57 15 940183 191 69988055
Natural killer cell count increased 13.28 11.57 6 940192 13 69988233
Cryptococcus test positive 13.28 11.57 6 940192 13 69988233
Self-consciousness 13.26 11.57 7 940191 24 69988222
Bezoar 13.25 11.57 7 940191 2299 69985947
Acral lentiginous melanoma 13.20 11.57 8 940190 38 69988208
Injection site haematoma 13.19 11.57 97 940101 4037 69984209
Back disorder 13.17 11.57 205 939993 10359 69977887
Hypertriglyceridaemia 13.16 11.57 225 939973 11586 69976660
Prostate cancer stage III 13.14 11.57 3 940195 1667 69986579
Symptom recurrence 13.14 11.57 45 940153 1370 69986876
Apathy 13.14 11.57 98 940100 11810 69976436
Intestinal stenosis 13.13 11.57 83 940115 3284 69984962
Trichosporon infection 13.11 11.57 35 940163 926 69987320
Monoclonal B-cell lymphocytosis 13.10 11.57 9 940189 55 69988191
Troponin T increased 13.09 11.57 9 940189 2561 69985685
Granulomatous liver disease 13.07 11.57 41 940157 1191 69987055
Device failure 13.06 11.57 37 940161 5798 69982448
Myelosuppression 13.06 11.57 506 939692 29639 69958607
Nasal polyps 13.03 11.57 25 940173 4491 69983755
Depressive symptom 13.02 11.57 31 940167 5150 69983096
Injection related reaction 13.01 11.57 31 940167 763 69987483
Hypokinesia 13.01 11.57 158 940040 17274 69970972
Human herpesvirus 8 infection 13.00 11.57 38 940160 1061 69987185
Colon cancer 12.98 11.57 264 939934 14042 69974204
Spinal cord compression 12.97 11.57 38 940160 5890 69982356
Lupus vasculitis 12.97 11.57 24 940174 492 69987754
Optic ischaemic neuropathy 12.96 11.57 10 940188 2682 69985564
International normalised ratio fluctuation 12.95 11.57 80 940118 3139 69985107
Sinus arrhythmia 12.93 11.57 5 940193 1973 69986273
Portal fibrosis 12.93 11.57 26 940172 568 69987678
Retinitis 12.93 11.57 97 940101 4063 69984183
Anti-cyclic citrullinated peptide antibody 12.92 11.57 83 940115 3302 69984944
Monoclonal gammopathy 12.91 11.57 31 940167 767 69987479
Lymphocele 12.90 11.57 3 940195 1646 69986600
Dysphoria 12.90 11.57 25 940173 4473 69983773
Loss of control of legs 12.87 11.57 4 940194 1810 69986436
White matter lesion 12.87 11.57 54 940144 1814 69986432
Pharyngeal inflammation 12.86 11.57 35 940163 937 69987309
Blood creatine increased 12.86 11.57 66 940132 8698 69979548
Discontinued product administered 12.85 11.57 9 940189 57 69988189
Premature baby 12.83 11.57 16 940182 3423 69984823
Lentigo 12.82 11.57 23 940175 460 69987786
Plasmablastic lymphoma 12.81 11.57 26 940172 572 69987674
Adenoviral hepatitis 12.79 11.57 32 940166 813 69987433
Hyperkeratosis 12.79 11.57 147 940051 6937 69981309
Oral infection 12.78 11.57 116 940082 5143 69983103
Nephrogenic diabetes insipidus 12.77 11.57 5 940193 1958 69986288
Implant site pain 12.75 11.57 5 940193 1956 69986290
Hepatic necrosis 12.75 11.57 65 940133 8581 69979665
Testicular seminoma (pure) 12.74 11.57 8 940190 41 69988205
Abortion induced 12.73 11.57 45 940153 6580 69981666
Disorganised speech 12.73 11.57 4 940194 1797 69986449
Tetany 12.72 11.57 7 940191 2247 69985999
Nail pitting 12.72 11.57 19 940179 324 69987922
Cyclic neutropenia 12.70 11.57 6 940192 15 69988231
Fontanelle bulging 12.70 11.57 6 940192 15 69988231
Portosplenomesenteric venous thrombosis 12.70 11.57 6 940192 15 69988231
Joint fluid drainage 12.70 11.57 18 940180 292 69987954
Hypergammaglobulinaemia 12.70 11.57 28 940170 654 69987592
Carpal tunnel decompression 12.69 11.57 25 940173 538 69987708
Spinal cord disorder 12.68 11.57 51 940147 1680 69986566
Viral load increased 12.62 11.57 10 940188 2646 69985600
Eczema infected 12.61 11.57 9 940189 59 69988187
Tissue injury 12.61 11.57 9 940189 59 69988187
Non-cardiac chest pain 12.61 11.57 69 940129 8946 69979300
Carbon dioxide decreased 12.60 11.57 14 940184 3152 69985094
Stress at work 12.60 11.57 37 940161 1036 69987210
Adenocarcinoma of the cervix 12.59 11.57 14 940184 175 69988071
Secondary amyloidosis 12.59 11.57 14 940184 175 69988071
Chloroma 12.58 11.57 30 940168 739 69987507
Herpes zoster meningitis 12.56 11.57 13 940185 149 69988097
Methaemoglobinaemia 12.54 11.57 28 940170 4758 69983488
Pulmonary function test decreased 12.54 11.57 47 940151 6754 69981492
Application site irritation 12.54 11.57 3 940195 1614 69986632
Deafness 12.53 11.57 340 939858 18963 69969283
Diffuse large B-cell lymphoma recurrent 12.52 11.57 84 940114 3392 69984854
Stoma site discharge 12.49 11.57 4 940194 1775 69986471
Complicated appendicitis 12.48 11.57 12 940186 125 69988121
Eyelid exfoliation 12.48 11.57 12 940186 125 69988121
Phototherapy 12.46 11.57 7 940191 28 69988218
Bursa disorder 12.46 11.57 16 940182 235 69988011
Follicle centre lymphoma, follicular grade I, II, III 12.45 11.57 10 940188 80 69988166
Lichen myxoedematosus 12.44 11.57 8 940190 43 69988203
Adult T-cell lymphoma/leukaemia recurrent 12.44 11.57 6 940192 16 69988230
Cervix carcinoma 12.43 11.57 59 940139 2091 69986155
Amyloidosis 12.43 11.57 71 940127 2708 69985538
Reversible airways obstruction 12.42 11.57 3 940195 1604 69986642
Right ventricular dysfunction 12.41 11.57 8 940190 2356 69985890
Vulvovaginitis streptococcal 12.40 11.57 5 940193 7 69988239
Central nervous system necrosis 12.39 11.57 17 940181 267 69987979
Infectious mononucleosis 12.39 11.57 54 940144 1845 69986401
Gastric neoplasm 12.39 11.57 19 940179 332 69987914
Subdural abscess 12.38 11.57 9 940189 61 69988185
Meningitis chemical 12.37 11.57 15 940183 207 69988039
Product dose omission in error 12.36 11.57 104 940094 4512 69983734
Eczema herpeticum 12.35 11.57 16 940182 237 69988009
Orthostatic intolerance 12.35 11.57 4 940194 1763 69986483
Rectal cancer 12.33 11.57 80 940118 3194 69985052
Antiphospholipid syndrome 12.30 11.57 50 940148 1655 69986591
Gastrointestinal lymphoma 12.29 11.57 13 940185 153 69988093
Leukaemia 12.28 11.57 117 940081 5258 69982988
Contrast media reaction 12.27 11.57 5 940193 1911 69986335
Torticollis 12.27 11.57 7 940191 2202 69986044
Bruxism 12.26 11.57 19 940179 3710 69984536
Herpes simplex reactivation 12.23 11.57 20 940178 370 69987876
Lower limb fracture 12.22 11.57 300 939898 16472 69971774
Bedridden 12.22 11.57 211 939987 10887 69977359
Hepatic infection fungal 12.21 11.57 15 940183 210 69988036
Arrhythmia supraventricular 12.21 11.57 5 940193 1905 69986341
Lung squamous cell carcinoma stage I 12.18 11.57 6 940192 17 69988229
Carotid intima-media thickness increased 12.17 11.57 10 940188 83 69988163
Mycobacterium haemophilum infection 12.17 11.57 10 940188 83 69988163
Haematocolpos 12.16 11.57 8 940190 45 69988201
Transplant evaluation 12.16 11.57 3 940195 1581 69986665
Lower respiratory tract congestion 12.16 11.57 81 940117 3263 69984983
Genital infection 12.15 11.57 9 940189 63 69988183
Sensitisation 12.15 11.57 9 940189 2464 69985782
Lipoma 12.15 11.57 71 940127 2731 69985515
Cytomegalovirus enteritis 12.14 11.57 29 940169 715 69987531
Endometriosis 12.14 11.57 79 940119 3157 69985089
Invasive breast carcinoma 12.13 11.57 24 940174 518 69987728
Attention deficit hyperactivity disorder 12.12 11.57 13 940185 2974 69985272
Psychiatric decompensation 12.12 11.57 13 940185 2974 69985272
Product storage error 12.11 11.57 265 939933 14276 69973970
Renal tubular atrophy 12.08 11.57 4 940194 1738 69986508
Malignant mediastinal neoplasm 12.07 11.57 32 940166 843 69987403
DNA antibody positive 12.07 11.57 17 940181 274 69987972
Injection site paraesthesia 12.07 11.57 24 940174 520 69987726
Intervertebral disc compression 12.07 11.57 36 940162 1017 69987229
Sensory disturbance 12.06 11.57 121 940077 13711 69974535
Carbon dioxide increased 12.06 11.57 6 940192 2039 69986207
Oxygen therapy 12.04 11.57 9 940189 2453 69985793
Herpes simplex meningoencephalitis 12.04 11.57 9 940189 64 69988182
Expired product administered 12.03 11.57 44 940154 6369 69981877
Chimerism 12.03 11.57 17 940181 275 69987971
Corneal oedema 12.02 11.57 9 940189 2451 69985795
Inability to afford medication 12.02 11.57 6 940192 2035 69986211
Squamous cell carcinoma of the vagina 12.01 11.57 5 940193 8 69988238
Ear canal stenosis 12.01 11.57 5 940193 8 69988238
Conjunctival deposit 12.01 11.57 5 940193 8 69988238
Upper limb fracture 11.95 11.57 289 939909 15830 69972416
Salivary gland neoplasm 11.94 11.57 11 940187 108 69988138
Silicosis 11.94 11.57 6 940192 18 69988228
Physical assault 11.93 11.57 3 940195 1561 69986685
Ossicle disorder 11.93 11.57 7 940191 31 69988215
Breast cancer metastatic 11.92 11.57 82 940116 10064 69978182
Poor quality product administered 11.91 11.57 16 940182 3315 69984931
Nocardiosis 11.90 11.57 112 940086 5017 69983229
Ischaemic hepatitis 11.90 11.57 16 940182 3313 69984933
Libido decreased 11.89 11.57 30 940168 4886 69983360
Cerebellar tumour 11.89 11.57 10 940188 86 69988160
Arthritis enteropathic 11.87 11.57 16 940182 247 69987999
Visual impairment 11.86 11.57 909 939289 79341 69908905
Coronavirus infection 11.86 11.57 131 940067 6121 69982125
Prescribed overdose 11.84 11.57 272 939926 26909 69961337
Decreased interest 11.83 11.57 17 940181 3424 69984822
Acute interstitial pneumonitis 11.83 11.57 37 940161 1073 69987173
Soft tissue disorder 11.83 11.57 81 940117 3293 69984953
Cerebral ischaemia 11.82 11.57 85 940113 10327 69977919
Aphasia 11.80 11.57 461 939737 42788 69945458
Thalamus haemorrhage 11.77 11.57 4 940194 1710 69986536
PCO2 increased 11.76 11.57 4 940194 1709 69986537
Nerve injury 11.73 11.57 165 940033 8159 69980087
Extradural abscess 11.73 11.57 40 940158 1215 69987031
Peripheral ischaemia 11.72 11.57 68 940130 8690 69979556
Tuberculosis of eye 11.72 11.57 9 940189 67 69988179
Large granular lymphocytosis 11.71 11.57 19 940179 349 69987897
Joint abscess 11.67 11.57 20 940178 385 69987861
Uterine disorder 11.66 11.57 55 940143 1944 69986302
Meningitis viral 11.66 11.57 51 940147 1745 69986501
Bronchopleural fistula 11.66 11.57 26 940172 612 69987634
Vulval cancer stage III 11.65 11.57 5 940193 9 69988237
Generalised anxiety disorder 11.65 11.57 6 940192 1999 69986247
Psoas abscess 11.62 11.57 33 940165 906 69987340
Derealisation 11.62 11.57 3 940195 1533 69986713
Mucosal atrophy 11.61 11.57 9 940189 68 69988178
Allergy to vaccine 11.60 11.57 13 940185 164 69988082
Cranial nerve disorder 11.59 11.57 36 940162 1040 69987206

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L01BA01 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
ANTIMETABOLITES
Folic acid analogues
ATC L04AX03 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
IMMUNOSUPPRESSANTS
IMMUNOSUPPRESSANTS
Other immunosuppressants
FDA MoA N0000000111 Folic Acid Metabolism Inhibitors
FDA EPC N0000175584 Folate Analog Metabolic Inhibitor
MeSH PA D000019 Abortifacient Agents
MeSH PA D000020 Abortifacient Agents, Nonsteroidal
MeSH PA D000963 Antimetabolites
MeSH PA D000964 Antimetabolites, Antineoplastic
MeSH PA D000970 Antineoplastic Agents
MeSH PA D018501 Antirheumatic Agents
MeSH PA D003879 Dermatologic Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D005493 Folic Acid Antagonists
MeSH PA D007155 Immunologic Factors
MeSH PA D007166 Immunosuppressive Agents
MeSH PA D009676 Noxae
MeSH PA D019384 Nucleic Acid Synthesis Inhibitors
MeSH PA D012102 Reproductive Control Agents
CHEBI has role CHEBI:35221 antimetabolite
CHEBI has role CHEBI:35610 antineoplastic agents
CHEBI has role CHEBI:35705 immunosuppressive agents
CHEBI has role CHEBI:35842 anti-rheumatic drugs
CHEBI has role CHEBI:50177 dermatologic agent
CHEBI has role CHEBI:50683 dihydrofolic acid reductase inhibitors
CHEBI has role CHEBI:50691 abortifacient drug
CHEBI has role CHEBI:59517 DNA synthesis inhibitors

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Psoriasis indication 9014002 DOID:8893
Rheumatoid arthritis indication 69896004 DOID:7148
Acute lymphoid leukemia indication 91857003 DOID:9952
Non-Hodgkin's lymphoma indication 118601006
Burkitt's lymphoma indication 118617000
Mycosis fungoides indication 118618005
Psoriatic arthritis indication 156370009 DOID:9008
Plaque psoriasis indication 200965009
Pustular psoriasis indication 200973000
Erythrodermic psoriasis indication 200977004
Malignant tumor of head and/or neck indication 255056009
Osteosarcoma of bone indication 307576001 DOID:3376
Malignant tumor of lung indication 363358000
Juvenile rheumatoid arthritis indication 410795001
Carcinoma of female breast indication 447782002
Gestational trophoblastic neoplasia indication 609519004 DOID:3590
Meningeal Leukemia indication
Polymyositis off-label use 31384009
Vasculitis off-label use 31996006 DOID:865
Psoriasis with arthropathy off-label use 33339001
Systemic lupus erythematosus off-label use 55464009 DOID:9074
Acute myeloid leukemia, disease off-label use 91861009
Acute promyelocytic leukemia, FAB M3 off-label use 110004001
Wegener's granulomatosis off-label use 195353004 DOID:12132
Malignant tumor of urinary bladder off-label use 399326009 DOID:11054
Systemic Dermatomyositis off-label use
Alcoholism contraindication 7200002
Peptic ulcer contraindication 13200003 DOID:750
Dehydration contraindication 34095006
Fibrosis of lung contraindication 51615001 DOID:3770
Acute nephropathy contraindication 58574008
Hepatic failure contraindication 59927004
Stomatitis contraindication 61170000 DOID:9637
Interstitial pneumonia contraindication 64667001
Ulcerative colitis contraindication 64766004 DOID:8577
Leukopenia contraindication 84828003 DOID:615
Kidney disease contraindication 90708001 DOID:557
Disease of liver contraindication 235856003 DOID:409
Anemia contraindication 271737000 DOID:2355
Pregnancy, function contraindication 289908002
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Bone marrow depression contraindication 307762000
Ascites contraindication 389026000
Gastric ulcer contraindication 397825006 DOID:10808
Breastfeeding (mother) contraindication 413712001
Disorder of immune function contraindication 414029004
Methotrexate Toxicity contraindication
Pleural Effusions contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.61 acidic
pKa2 5.15 acidic
pKa3 12.92 acidic
pKa4 5.73 Basic
pKa5 4.51 Basic
pKa6 1.39 Basic
pKa7 0.75 Basic
pKa8 0.08 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
10MG/0.20ML (10MG/0.20ML) RASUVO MEDEXUS N205776 July 10, 2014 RX SOLUTION SUBCUTANEOUS 8664231 June 1, 2029 SUBCUTANEOUS INJECTION OF METHOTREXATE
12.5MG/0.25ML (12.5MG/0.25ML) RASUVO MEDEXUS N205776 July 10, 2014 RX SOLUTION SUBCUTANEOUS 8664231 June 1, 2029 SUBCUTANEOUS INJECTION OF METHOTREXATE
15MG/0.30ML (15MG/0.30ML) RASUVO MEDEXUS N205776 July 10, 2014 RX SOLUTION SUBCUTANEOUS 8664231 June 1, 2029 SUBCUTANEOUS INJECTION OF METHOTREXATE
17.5MG/0.35ML (17.5MG/0.35ML) RASUVO MEDEXUS N205776 July 10, 2014 RX SOLUTION SUBCUTANEOUS 8664231 June 1, 2029 SUBCUTANEOUS INJECTION OF METHOTREXATE
20MG/0.4ML (20MG/0.4ML) RASUVO MEDEXUS N205776 July 10, 2014 RX SOLUTION SUBCUTANEOUS 8664231 June 1, 2029 SUBCUTANEOUS INJECTION OF METHOTREXATE
22.5MG/0.45ML (22.5MG/0.45ML) RASUVO MEDEXUS N205776 July 10, 2014 RX SOLUTION SUBCUTANEOUS 8664231 June 1, 2029 SUBCUTANEOUS INJECTION OF METHOTREXATE
25MG/0.5ML (25MG/0.5ML) RASUVO MEDEXUS N205776 July 10, 2014 RX SOLUTION SUBCUTANEOUS 8664231 June 1, 2029 SUBCUTANEOUS INJECTION OF METHOTREXATE
27.5MG/0.55ML (27.5MG/0.55ML) RASUVO MEDEXUS N205776 July 10, 2014 DISCN SOLUTION SUBCUTANEOUS 8664231 June 1, 2029 SUBCUTANEOUS INJECTION OF METHOTREXATE
30MG/0.6ML (30MG/0.6ML) RASUVO MEDEXUS N205776 July 10, 2014 RX SOLUTION SUBCUTANEOUS 8664231 June 1, 2029 SUBCUTANEOUS INJECTION OF METHOTREXATE
7.5MG/0.15ML (7.5MG/0.15ML) RASUVO MEDEXUS N205776 July 10, 2014 RX SOLUTION SUBCUTANEOUS 8664231 June 1, 2029 SUBCUTANEOUS INJECTION OF METHOTREXATE
10MG/0.4ML (10MG/0.4ML) OTREXUP OTTER PHARMS N204824 Oct. 11, 2013 RX SOLUTION SUBCUTANEOUS 8480631 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
10MG/0.4ML (10MG/0.4ML) OTREXUP OTTER PHARMS N204824 Oct. 11, 2013 RX SOLUTION SUBCUTANEOUS 8579865 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
10MG/0.4ML (10MG/0.4ML) OTREXUP OTTER PHARMS N204824 Oct. 11, 2013 RX SOLUTION SUBCUTANEOUS 8945063 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
10MG/0.4ML (10MG/0.4ML) OTREXUP OTTER PHARMS N204824 Oct. 11, 2013 RX SOLUTION SUBCUTANEOUS 9421333 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
12.5MG/0.4ML (12.5MG/0.4ML) OTREXUP OTTER PHARMS N204824 March 24, 2016 RX SOLUTION SUBCUTANEOUS 8480631 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
12.5MG/0.4ML (12.5MG/0.4ML) OTREXUP OTTER PHARMS N204824 March 24, 2016 RX SOLUTION SUBCUTANEOUS 8579865 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
12.5MG/0.4ML (12.5MG/0.4ML) OTREXUP OTTER PHARMS N204824 March 24, 2016 RX SOLUTION SUBCUTANEOUS 8945063 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
12.5MG/0.4ML (12.5MG/0.4ML) OTREXUP OTTER PHARMS N204824 March 24, 2016 RX SOLUTION SUBCUTANEOUS 9421333 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
15MG/0.4ML (15MG/0.4ML) OTREXUP OTTER PHARMS N204824 Oct. 11, 2013 RX SOLUTION SUBCUTANEOUS 8480631 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
15MG/0.4ML (15MG/0.4ML) OTREXUP OTTER PHARMS N204824 Oct. 11, 2013 RX SOLUTION SUBCUTANEOUS 8579865 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
15MG/0.4ML (15MG/0.4ML) OTREXUP OTTER PHARMS N204824 Oct. 11, 2013 RX SOLUTION SUBCUTANEOUS 8945063 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
15MG/0.4ML (15MG/0.4ML) OTREXUP OTTER PHARMS N204824 Oct. 11, 2013 RX SOLUTION SUBCUTANEOUS 9421333 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
17.5MG/0.4ML (17.5MG/0.4ML) OTREXUP OTTER PHARMS N204824 March 24, 2016 RX SOLUTION SUBCUTANEOUS 8480631 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
17.5MG/0.4ML (17.5MG/0.4ML) OTREXUP OTTER PHARMS N204824 March 24, 2016 RX SOLUTION SUBCUTANEOUS 8579865 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
17.5MG/0.4ML (17.5MG/0.4ML) OTREXUP OTTER PHARMS N204824 March 24, 2016 RX SOLUTION SUBCUTANEOUS 8945063 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
17.5MG/0.4ML (17.5MG/0.4ML) OTREXUP OTTER PHARMS N204824 March 24, 2016 RX SOLUTION SUBCUTANEOUS 9421333 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
20MG/0.4ML (20MG/0.4ML) OTREXUP OTTER PHARMS N204824 Oct. 11, 2013 RX SOLUTION SUBCUTANEOUS 8480631 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
20MG/0.4ML (20MG/0.4ML) OTREXUP OTTER PHARMS N204824 Oct. 11, 2013 RX SOLUTION SUBCUTANEOUS 8579865 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
20MG/0.4ML (20MG/0.4ML) OTREXUP OTTER PHARMS N204824 Oct. 11, 2013 RX SOLUTION SUBCUTANEOUS 8945063 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
20MG/0.4ML (20MG/0.4ML) OTREXUP OTTER PHARMS N204824 Oct. 11, 2013 RX SOLUTION SUBCUTANEOUS 9421333 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
22.5MG/0.4ML (22.5MG/0.4ML) OTREXUP OTTER PHARMS N204824 March 24, 2016 RX SOLUTION SUBCUTANEOUS 8480631 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
22.5MG/0.4ML (22.5MG/0.4ML) OTREXUP OTTER PHARMS N204824 March 24, 2016 RX SOLUTION SUBCUTANEOUS 8579865 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
22.5MG/0.4ML (22.5MG/0.4ML) OTREXUP OTTER PHARMS N204824 March 24, 2016 RX SOLUTION SUBCUTANEOUS 8945063 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
22.5MG/0.4ML (22.5MG/0.4ML) OTREXUP OTTER PHARMS N204824 March 24, 2016 RX SOLUTION SUBCUTANEOUS 9421333 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
25MG/0.4ML (25MG/0.4ML) OTREXUP OTTER PHARMS N204824 Oct. 11, 2013 RX SOLUTION SUBCUTANEOUS 8480631 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
25MG/0.4ML (25MG/0.4ML) OTREXUP OTTER PHARMS N204824 Oct. 11, 2013 RX SOLUTION SUBCUTANEOUS 8579865 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
25MG/0.4ML (25MG/0.4ML) OTREXUP OTTER PHARMS N204824 Oct. 11, 2013 RX SOLUTION SUBCUTANEOUS 8945063 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
25MG/0.4ML (25MG/0.4ML) OTREXUP OTTER PHARMS N204824 Oct. 11, 2013 RX SOLUTION SUBCUTANEOUS 9421333 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
7.5MG/0.4ML (7.5MG/0.4ML) OTREXUP OTTER PHARMS N204824 Nov. 7, 2014 DISCN SOLUTION SUBCUTANEOUS 8480631 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
7.5MG/0.4ML (7.5MG/0.4ML) OTREXUP OTTER PHARMS N204824 Nov. 7, 2014 DISCN SOLUTION SUBCUTANEOUS 8579865 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
7.5MG/0.4ML (7.5MG/0.4ML) OTREXUP OTTER PHARMS N204824 Nov. 7, 2014 DISCN SOLUTION SUBCUTANEOUS 8945063 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
7.5MG/0.4ML (7.5MG/0.4ML) OTREXUP OTTER PHARMS N204824 Nov. 7, 2014 DISCN SOLUTION SUBCUTANEOUS 9421333 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
EQ 2.5MG BASE/ML XATMEP AZURITY N208400 April 25, 2017 RX SOLUTION ORAL 10231927 Jan. 2, 2033 A METHOD FOR TREATING ACUTE LYMPHOBLASTIC LEUKEMIA
EQ 2.5MG BASE/ML XATMEP AZURITY N208400 April 25, 2017 RX SOLUTION ORAL 10231927 Jan. 2, 2033 TREATMENT OF JUVENILE RHEUMATOID ARTHRITIS
EQ 2.5MG BASE/ML XATMEP AZURITY N208400 April 25, 2017 RX SOLUTION ORAL 11116724 Jan. 2, 2033 A METHOD FOR TREATING ACUTE LYMPHOBLASTIC LEUKEMIA
EQ 2.5MG BASE/ML XATMEP AZURITY N208400 April 25, 2017 RX SOLUTION ORAL 11116724 Jan. 2, 2033 TREATMENT OF JUVENILE RHEUMATOID ARTHRITIS

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
EQ 2.5MG BASE/ML XATMEP AZURITY N208400 April 25, 2017 RX SOLUTION ORAL April 25, 2024 TREATMENT OF OLIGOARTICULAR JUVENILE IDIOPATHIC ARTHRITIS (PERSISTENT OLIGOARTHRITIS, PSORIATIC JUVENILE IDIOPATHIC ARTHRITIS, ENTHESITIS-RELATED ARTHRITIS, OR UNDIFFERENTIATED ARTHRITIS) & POLYARTICULAR JUVENILE IDIOPATHIC ARTHRITIS IN CHILDREN 0-16 YRS
EQ 2.5MG BASE/ML XATMEP AZURITY N208400 April 25, 2017 RX SOLUTION ORAL April 25, 2024 TREATMENT OF PEDIATRIC PATIENTS WITH ACUTE LYMPHOBLASTIC LEUKEMIA AS A COMPONENT OF A COMBINATION CHEOMOTHERAPY MAINTENANCE REGIMEN

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Dihydrofolate reductase Enzyme INHIBITOR Ki 8.92 IUPHAR DRUG LABEL
Multidrug resistance protein 1 Transporter WOMBAT-PK
Canalicular multispecific organic anion transporter 1 Transporter WOMBAT-PK
Multidrug resistance-associated protein 1 Transporter WOMBAT-PK
ATP-binding cassette sub-family G member 2 Transporter WOMBAT-PK
Thymidylate synthase Enzyme Ki 6.22 CHEMBL
Folylpolyglutamate synthase, mitochondrial Enzyme IC50 5.49 CHEMBL
Multidrug resistance-associated protein 4 Transporter WOMBAT-PK
Folate receptor beta Membrane receptor IC50 6.97 CHEMBL
Proton-coupled folate transporter Transporter IC50 6.92 CHEMBL
Multidrug resistance-associated protein 5 Transporter WOMBAT-PK
Toll-like receptor 4 Membrane receptor IC50 5.98 CHEMBL
Folate transporter 1 Transporter Ki 5.46 CHEMBL
Folate receptor alpha Membrane receptor IC50 6.94 CHEMBL
High mobility group protein B1 Nuclear other Kd 7.62 CHEMBL
Bifunctional purine biosynthesis protein PURH Enzyme Ki 6.06 CHEMBL
Bifunctional dihydrofolate reductase-thymidylate synthase Enzyme IC50 8.85 CHEMBL
Dihydrofolate reductase Enzyme IC50 9 CHEMBL
Bifunctional dihydrofolate reductase-thymidylate synthase Enzyme IC50 7.08 CHEMBL
Dihydrofolate reductase Enzyme Ki 5.41 CHEMBL
Dihydrofolate reductase Enzyme Ki 10.14 CHEMBL
Dihydrofolate reductase Enzyme Ki 10.68 CHEMBL
Dihydrofolate reductase Enzyme IC50 8.89 CHEMBL
Bifunctional dihydrofolate reductase-thymidylate synthase Enzyme Ki 9.89 CHEMBL
Dihydrofolate reductase Enzyme IC50 7.72 CHEMBL
Thymidylate synthase Enzyme IC50 4.40 CHEMBL
Dihydrofolate reductase Enzyme Ki 10.68 CHEMBL
Thymidylate synthase Enzyme IC50 5.74 CHEMBL
Pteridine reductase 1 Enzyme Ki 7.41 CHEMBL
Dihydrofolate reductase Enzyme Ki 9 CHEMBL
Dihydrofolate reductase Enzyme IC50 8.08 CHEMBL
Dihydrofolate reductase Enzyme IC50 7.91 CHEMBL
Dihydrofolate reductase Enzyme IC50 8.77 CHEMBL
Dihydrofolate reductase Enzyme IC50 8.85 CHEMBL
Thymidylate synthase Enzyme Ki 4.35 CHEMBL

External reference:

IDSource
4019828 VUID
N0000147916 NUI
D00142 KEGG_DRUG
7413-34-5 SECONDARY_CAS_RN
4017903 VANDF
4019828 VANDF
C0025677 UMLSCUI
CHEBI:44185 CHEBI
MTX PDB_CHEM_ID
CHEMBL34259 ChEMBL_ID
CHEMBL426 ChEMBL_ID
CHEMBL3244648 ChEMBL_ID
D008727 MESH_DESCRIPTOR_UI
DB00563 DRUGBANK_ID
4815 IUPHAR_LIGAND_ID
926 INN_ID
YL5FZ2Y5U1 UNII
126941 PUBCHEM_CID
287734 RXNORM
12261 MMSL
30391 MMSL
5077 MMSL
6313 MMSL
73119 MMSL
d00060 MMSL
002644 NDDF
002645 NDDF
387381009 SNOMEDCT_US
412247000 SNOMEDCT_US
68887009 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Methotrexate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0054-4550 TABLET 2.50 mg ORAL ANDA 28 sections
Methotrexate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0054-8550 TABLET 2.50 mg ORAL ANDA 28 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 0143-9367 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 1 g INTRA-ARTERIAL ANDA 23 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 0143-9516 SOLUTION 25 mg INTRA-ARTERIAL ANDA 33 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 0143-9517 SOLUTION 25 mg INTRA-ARTERIAL ANDA 33 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 0143-9518 SOLUTION 25 mg INTRA-ARTERIAL ANDA 33 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 0143-9519 SOLUTION 25 mg INTRA-ARTERIAL ANDA 33 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 0143-9830 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 1 g INTRA-ARTERIAL ANDA 23 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 0378-0014 TABLET 2.50 mg ORAL ANDA 28 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 0378-0014 TABLET 2.50 mg ORAL ANDA 28 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 0555-0572 TABLET 2.50 mg ORAL ANDA 28 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 0555-0572 TABLET 2.50 mg ORAL ANDA 28 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 0703-3671 INJECTION, SOLUTION 25 mg INTRA-ARTERIAL ANDA 28 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 0703-3675 INJECTION, SOLUTION 25 mg INTRA-ARTERIAL ANDA 28 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 0703-3678 INJECTION, SOLUTION 25 mg INTRA-ARTERIAL ANDA 28 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 0703-3678 INJECTION, SOLUTION 25 mg INTRA-ARTERIAL ANDA 28 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 0703-3678 INJECTION, SOLUTION 25 mg INTRA-ARTERIAL ANDA 28 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 0904-7141 TABLET 2.50 mg ORAL ANDA 26 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 0904-7141 TABLET 2.50 mg ORAL ANDA 26 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 16729-277 INJECTION 25 mg INTRA-ARTERIAL ANDA 29 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 16729-486 TABLET 2.50 mg ORAL ANDA 30 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 42291-505 TABLET 2.50 mg ORAL ANDA 28 sections
Methotrexate Human Prescription Drug Label 1 47335-235 TABLET 2.50 mg ORAL ANDA 30 sections
METHOTREXATE HUMAN PRESCRIPTION DRUG LABEL 1 47781-482 TABLET 2.50 mg ORAL ANDA 27 sections
Methotrexate Human Prescription Drug Label 1 50090-3418 TABLET 2.50 mg ORAL ANDA 30 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 50090-5457 TABLET 2.50 mg ORAL ANDA 28 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 50268-527 TABLET 2.50 mg ORAL ANDA 28 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 50268-527 TABLET 2.50 mg ORAL ANDA 28 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 51079-570 TABLET 2.50 mg ORAL ANDA 29 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 51079-670 TABLET 2.50 mg ORAL ANDA 29 sections