methotrexate Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
folic acid analogues 1751 59-05-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • methotrexate
  • methotrexate sodium
  • amethopterin
  • amethopterine
  • L-Amethopterin
  • ledertrexate
  • metatrexan
  • methoxtrexate
  • methylaminopterin
An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.
  • Molecular weight: 454.45
  • Formula: C20H22N8O5
  • CLOGP: -0.53
  • LIPINSKI: 1
  • HAC: 13
  • HDO: 5
  • TPSA: 210.54
  • ALOGS: -3.42
  • ROTB: 9
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
2.50 mg O
2.50 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.45 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 81 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 1.10 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 33 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.43 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 2.10 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.37 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 3.90 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Dec. 7, 1953 FDA DAVA PHARMS INC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 43979.28 19.49 14727 39593 86897 2216868
Rheumatoid arthritis 15946.74 19.49 4688 49632 14452 2289313
Drug intolerance 13125.57 19.49 3749 50571 9968 2293797
Drug hypersensitivity 9895.14 19.49 4125 50195 42518 2261247
Treatment failure 8723.33 19.49 2377 51943 4862 2298903
Therapeutic product effect incomplete 6834.18 19.49 2140 52180 8391 2295374
Joint swelling 6287.31 19.49 2256 52064 14563 2289202
Nausea 5585.11 19.49 3768 50552 108421 2195344
Contraindicated product administered 5518.65 19.49 1383 52937 1638 2302127
Arthralgia 5498.94 19.49 2890 51430 51395 2252370
Alopecia 5271.77 19.49 2134 52186 19867 2283898
Synovitis 4843.91 19.49 1221 53099 1505 2302260
Pain 4484.51 19.49 2645 51675 59212 2244553
Liver function test increased 4231.54 19.49 1126 53194 1975 2301790
Therapeutic product effect decreased 4089.96 19.49 1465 52855 9324 2294441
Condition aggravated 3996.26 19.49 1967 52353 30012 2273753
Abdominal discomfort 3840.52 19.49 1595 52725 15861 2287904
Pancytopenia 3246.30 19.49 1257 53063 10195 2293570
Fatigue 3192.90 19.49 2415 51905 82458 2221307
Infection 3004.99 19.49 1355 52965 16674 2287091
Musculoskeletal stiffness 2900.94 19.49 1181 53139 11066 2292699
Hepatic enzyme increased 2841.51 19.49 1094 53226 8708 2295057
Rash 2695.08 19.49 1898 52422 57660 2246105
Peripheral swelling 2582.06 19.49 1211 53109 16386 2287379
Pneumonia 2436.98 19.49 1660 52660 47636 2256129
Gastrointestinal disorder 2272.59 19.49 907 53413 8010 2295755
Vomiting 2262.87 19.49 1842 52478 69760 2234005
Arthropathy 2257.22 19.49 855 53465 6461 2297304
C-reactive protein abnormal 1983.41 19.49 469 53851 330 2303435
Loss of personal independence in daily activities 1932.86 19.49 701 53619 4610 2299155
Diarrhoea 1876.95 19.49 1771 52549 81793 2221972
Pain in extremity 1839.10 19.49 1321 52999 41219 2262546
Mouth ulceration 1812.19 19.49 618 53702 3294 2300471
Mucosal inflammation 1809.89 19.49 665 53655 4559 2299206
Headache 1789.97 19.49 1694 52626 78485 2225280
Pyrexia 1782.91 19.49 1424 52896 52284 2251481
Swelling 1745.94 19.49 907 53413 15443 2288322
Malaise 1731.38 19.49 1420 52900 54165 2249600
Interstitial lung disease 1703.81 19.49 711 53609 7101 2296664
Off label use 1693.73 19.49 1582 52738 72016 2231749
Stomatitis 1685.47 19.49 752 53568 8958 2294807
C-reactive protein increased 1529.51 19.49 618 53702 5637 2298128
Arthritis 1506.12 19.49 701 53619 9267 2294498
Pemphigus 1497.51 19.49 362 53958 314 2303451
Febrile neutropenia 1414.33 19.49 690 53630 10192 2293573
Sepsis 1327.07 19.49 790 53530 17698 2286067
Product use in unapproved indication 1306.81 19.49 660 53660 10540 2293225
Toxicity to various agents 1286.41 19.49 961 53359 31793 2271972
Systemic lupus erythematosus 1274.43 19.49 486 53834 3735 2300030
Lymphoproliferative disorder 1265.11 19.49 310 54010 302 2303463
Red blood cell sedimentation rate abnormal 1261.37 19.49 300 54020 223 2303542
Hand deformity 1234.56 19.49 342 53978 744 2303021
Lung disorder 1226.32 19.49 527 53793 5685 2298080
Rheumatoid factor positive 1220.84 19.49 291 54029 221 2303544
Leukopenia 1204.53 19.49 606 53714 9590 2294175
Mobility decreased 1193.86 19.49 575 53745 8235 2295530
Herpes zoster 1151.67 19.49 579 53741 9146 2294619
Pneumocystis jirovecii pneumonia 1142.54 19.49 382 53938 1891 2301874
Hypersensitivity 1140.98 19.49 786 53534 22807 2280958
Osteoarthritis 1128.56 19.49 514 53806 6432 2297333
Neutropenia 1096.72 19.49 741 53579 20807 2282958
Musculoskeletal pain 1067.40 19.49 570 53750 10260 2293505
Rheumatoid nodule 1057.18 19.49 269 54051 349 2303416
Bone marrow failure 1007.13 19.49 447 53873 5239 2298526
Cough 1005.00 19.49 835 53485 32282 2271483
Liver function test abnormal 993.92 19.49 482 53838 7008 2296757
Red blood cell sedimentation rate increased 990.69 19.49 338 53982 1799 2301966
Pulmonary fibrosis 958.01 19.49 348 53972 2292 2301473
Gait disturbance 948.34 19.49 690 53630 21855 2281910
Inflammation 947.32 19.49 440 53880 5773 2297992
Bone erosion 917.35 19.49 236 54084 330 2303435
Dyspnoea 901.08 19.49 1175 53145 77558 2226207
Weight decreased 897.38 19.49 733 53587 27638 2276127
Pneumonitis 877.79 19.49 367 53953 3672 2300093
Sinusitis 870.88 19.49 581 53739 15945 2287820
Septic shock 867.34 19.49 431 53889 6623 2297142
Lower respiratory tract infection 867.12 19.49 397 53923 5027 2298738
Thrombocytopenia 846.63 19.49 604 53716 18527 2285238
Abdominal pain 831.67 19.49 762 53558 33612 2270153
Adverse drug reaction 816.04 19.49 436 53884 7847 2295918
Febrile bone marrow aplasia 802.53 19.49 232 54088 625 2303140
Fibromyalgia 802.52 19.49 325 53995 2975 2300790
Psoriatic arthropathy 801.70 19.49 341 53979 3573 2300192
Nasopharyngitis 795.98 19.49 616 53704 21440 2282325
Hepatotoxicity 778.97 19.49 323 53997 3158 2300607
Skin ulcer 770.12 19.49 335 53985 3724 2300041
Joint range of motion decreased 757.63 19.49 267 54053 1589 2302176
Anaemia 752.80 19.49 725 53595 34067 2269698
Therapeutic response decreased 743.40 19.49 391 53929 6804 2296961
Psoriasis 743.26 19.49 533 53787 16475 2287290
Epstein-Barr virus infection 743.12 19.49 232 54088 879 2302886
Product use issue 739.50 19.49 468 53852 11701 2292064
Joint stiffness 721.02 19.49 319 54001 3704 2300061
Bronchitis 717.17 19.49 480 53840 13234 2290531
Knee arthroplasty 716.92 19.49 290 54030 2645 2301120
Liver disorder 715.55 19.49 367 53953 6047 2297718
Urinary tract infection 710.84 19.49 657 53663 29285 2274480
Glossodynia 707.89 19.49 257 54063 1688 2302077
Diffuse large B-cell lymphoma 689.62 19.49 207 54113 663 2303102
Nodule 688.52 19.49 261 54059 1965 2301800
Hepatic steatosis 681.52 19.49 287 54033 2926 2300839
Alanine aminotransferase increased 681.06 19.49 469 53851 13563 2290202
Transaminases increased 659.38 19.49 312 54008 4275 2299490
Hypertension 658.35 19.49 605 53715 26756 2277009
Anti-cyclic citrullinated peptide antibody positive 641.10 19.49 145 54175 58 2303707
Back pain 640.31 19.49 636 53684 31023 2272742
Abdominal pain upper 617.67 19.49 532 53788 21568 2282197
Asthenia 615.89 19.49 751 53569 46175 2257590
Drug interaction 614.14 19.49 599 53721 28564 2275201
Musculoskeletal disorder 600.99 19.49 245 54075 2283 2301482
Posterior reversible encephalopathy syndrome 591.81 19.49 241 54079 2239 2301526
Therapy non-responder 582.34 19.49 347 53973 7757 2296008
Pulmonary mass 581.87 19.49 222 54098 1704 2302061
Hepatitis 564.08 19.49 312 54008 6025 2297740
Respiratory failure 547.77 19.49 405 53915 13123 2290642
Ulcer 522.69 19.49 204 54116 1676 2302089
Injection site reaction 513.64 19.49 407 53913 14645 2289120
Foot deformity 508.06 19.49 203 54117 1786 2301979
Basal cell carcinoma 507.10 19.49 221 54099 2466 2301299
Diverticulitis 504.41 19.49 252 54068 3913 2299852
Disability 503.53 19.49 161 54159 671 2303094
Dizziness 503.46 19.49 764 53556 57901 2245864
Joint effusion 499.59 19.49 178 54142 1098 2302667
Neck pain 495.00 19.49 307 54013 7390 2296375
Neurotoxicity 494.61 19.49 203 54117 1927 2301838
Acute kidney injury 494.16 19.49 524 53796 27598 2276167
Osteoporosis 490.56 19.49 252 54068 4162 2299603
Anaphylactic reaction 476.89 19.49 327 53993 9378 2294387
Diabetes mellitus 469.50 19.49 294 54026 7201 2296564
Pharyngitis 465.12 19.49 197 54123 2038 2301727
Pruritus 463.52 19.49 627 53693 42713 2261052
Hip arthroplasty 458.55 19.49 186 54134 1708 2302057
Non-Hodgkin's lymphoma 456.54 19.49 153 54167 762 2303003
Cellulitis 454.41 19.49 311 54009 8890 2294875
Cytomegalovirus infection 453.67 19.49 205 54115 2508 2301257
Tenderness 452.86 19.49 185 54135 1733 2302032
Fall 449.42 19.49 645 53675 46454 2257311
Breast cancer 447.90 19.49 312 54008 9183 2294582
Blood iron abnormal 446.59 19.49 105 54215 69 2303696
Eye disorder 438.32 19.49 211 54109 3008 2300757
Sleep disorder 438.08 19.49 267 54053 6222 2297543
Renal impairment 437.62 19.49 315 54005 9777 2293988
Grip strength decreased 434.92 19.49 153 54167 904 2302861
Fear of injection 432.55 19.49 147 54173 770 2302995
Aspartate aminotransferase increased 432.31 19.49 342 53978 12270 2291495
Leukoencephalopathy 426.80 19.49 141 54179 666 2303099
Maternal exposure during pregnancy 425.59 19.49 363 53957 14500 2289265
Multiple organ dysfunction syndrome 422.30 19.49 277 54043 7364 2296401
Adverse reaction 412.68 19.49 164 54156 1420 2302345
Ear infection 410.19 19.49 206 54114 3235 2300530
Tenosynovitis 405.59 19.49 122 54198 394 2303371
Infusion related reaction 404.82 19.49 297 54023 9499 2294266
Decreased appetite 402.38 19.49 477 53843 28414 2275351
Respiratory tract infection 399.14 19.49 213 54107 3816 2299949
White blood cell count decreased 396.08 19.49 381 53939 17827 2285938
Impaired work ability 394.88 19.49 165 54155 1645 2302120
Venoocclusive liver disease 394.18 19.49 124 54196 484 2303281
Deformity 379.87 19.49 115 54205 382 2303383
Hypoaesthesia 378.76 19.49 390 53930 19825 2283940
Acute myeloid leukaemia 373.10 19.49 179 54141 2531 2301234
Erythema 373.00 19.49 429 53891 24730 2279035
Pleural effusion 369.27 19.49 302 54018 11366 2292399
Hepatocellular injury 367.24 19.49 202 54118 3853 2299912
Dry eye 366.37 19.49 200 54120 3756 2300009
Haemophagocytic lymphohistiocytosis 363.11 19.49 144 54176 1239 2302526
Tuberculosis 351.63 19.49 155 54165 1780 2301985
Adverse event 350.29 19.49 247 54073 7412 2296353
Staphylococcal infection 346.34 19.49 214 54106 5112 2298653
Renal failure 345.56 19.49 346 53974 17003 2286762
Disease recurrence 343.41 19.49 183 54137 3268 2300497
Spinal stenosis 338.95 19.49 138 54182 1280 2302485
Epstein-Barr virus associated lymphoproliferative disorder 337.81 19.49 93 54227 195 2303570
Fine motor skill dysfunction 337.17 19.49 95 54225 225 2303540
Immunosuppression 336.50 19.49 127 54193 942 2302823
Hypofibrinogenaemia 335.54 19.49 81 54239 69 2303696
Deafness transitory 334.41 19.49 84 54236 99 2303666
General physical health deterioration 328.67 19.49 307 54013 13832 2289933
Urticaria 326.92 19.49 394 53926 23867 2279898
Upper respiratory tract infection 324.88 19.49 250 54070 8601 2295164
Lymphoma 321.46 19.49 146 54174 1808 2301957
Dermatitis allergic 320.93 19.49 148 54172 1903 2301862
Finger deformity 320.33 19.49 115 54205 727 2303038
Haematotoxicity 318.62 19.49 125 54195 1042 2302723
Panniculitis 317.46 19.49 102 54218 433 2303332
Oral pain 315.28 19.49 172 54148 3225 2300540
Crohn's disease 314.53 19.49 219 54101 6436 2297329
Gastrointestinal pain 314.45 19.49 122 54198 984 2302781
Sciatica 312.84 19.49 147 54173 1978 2301787
Stress 310.91 19.49 221 54099 6717 2297048
Tuberculin test positive 310.29 19.49 103 54217 495 2303270
Wound 309.60 19.49 158 54162 2570 2301195
Influenza 307.83 19.49 285 54035 12693 2291072
Lymphadenopathy 306.15 19.49 203 54117 5495 2298270
Disease progression 306.15 19.49 322 53998 16773 2286992
Glaucoma 305.57 19.49 144 54176 1951 2301814
Drug resistance 300.77 19.49 153 54167 2471 2301294
Impaired healing 298.55 19.49 196 54124 5215 2298550
Myelodysplastic syndrome 298.48 19.49 151 54169 2409 2301356
Joint injury 294.43 19.49 147 54173 2277 2301488
Skin necrosis 294.27 19.49 117 54203 1014 2302751
Skin lesion 293.31 19.49 174 54146 3851 2299914
Pulmonary toxicity 292.14 19.49 102 54218 587 2303178
Muscular weakness 289.11 19.49 293 54027 14604 2289161
Pneumonia viral 287.95 19.49 92 54228 382 2303383
Arthritis bacterial 286.11 19.49 105 54215 713 2303052
Influenza like illness 283.39 19.49 264 54056 11850 2291915
B-cell lymphoma 282.93 19.49 99 54221 574 2303191
Deafness 282.25 19.49 148 54172 2553 2301212
Juvenile idiopathic arthritis 281.06 19.49 90 54230 377 2303388
Hodgkin's disease 275.06 19.49 93 54227 478 2303287
Bursitis 274.76 19.49 130 54190 1778 2301987
Cataract 273.54 19.49 192 54128 5716 2298049
Drug-induced liver injury 272.40 19.49 161 54159 3538 2300227
Gastric disorder 271.95 19.49 161 54159 3549 2300216
Blood pressure increased 267.51 19.49 299 54021 16687 2287078
Depression 266.05 19.49 384 53936 27748 2276017
Platelet count decreased 263.98 19.49 287 54033 15526 2288239
Contusion 263.37 19.49 260 54060 12550 2291215
Encephalitis 262.56 19.49 110 54210 1104 2302661
Immunodeficiency 261.57 19.49 106 54214 970 2302795
Malignant melanoma 260.38 19.49 127 54193 1865 2301900
Acute graft versus host disease 258.63 19.49 90 54230 512 2303253
Hypophagia 258.22 19.49 160 54160 3840 2299925
Angiocentric lymphoma 257.81 19.49 62 54258 51 2303714
Acute respiratory distress syndrome 257.49 19.49 149 54171 3143 2300622
Synovial cyst 254.56 19.49 98 54222 772 2302993
Weight increased 253.47 19.49 333 53987 22004 2281761
Sjogren's syndrome 253.08 19.49 102 54218 919 2302846
Granuloma skin 252.58 19.49 62 54258 61 2303704
Hepatic cirrhosis 251.78 19.49 131 54189 2222 2301543
Haemoglobin decreased 251.35 19.49 299 54021 17852 2285913
Blood cholesterol increased 251.23 19.49 174 54146 5067 2298698
Second primary malignancy 251.08 19.49 101 54219 905 2302860
Colitis 249.33 19.49 173 54147 5053 2298712
Graft versus host disease 248.78 19.49 99 54221 860 2302905
Bronchiectasis 248.58 19.49 99 54221 862 2302903
Maternal exposure before pregnancy 248.52 19.49 96 54224 764 2303001
Visual impairment 248.02 19.49 242 54078 11513 2292252
Localised infection 245.98 19.49 138 54182 2738 2301027
Varicella zoster virus infection 244.56 19.49 76 54244 282 2303483
Candida infection 243.40 19.49 137 54183 2736 2301029
Shoulder arthroplasty 241.51 19.49 77 54243 317 2303448
Encephalopathy 241.40 19.49 161 54159 4400 2299365
Adenovirus infection 240.59 19.49 74 54246 263 2303502
Oropharyngeal pain 239.05 19.49 235 54085 11283 2292482
Cushingoid 238.41 19.49 85 54235 525 2303240
Drug eruption 237.75 19.49 141 54179 3118 2300647
Hypotension 236.97 19.49 393 53927 32043 2271722
Fungal infection 235.96 19.49 163 54157 4726 2299039
Pulmonary tuberculosis 235.30 19.49 93 54227 792 2302973
Neutropenic sepsis 231.70 19.49 106 54214 1336 2302429
Gait inability 231.27 19.49 174 54146 5781 2297984
Joint destruction 227.94 19.49 71 54249 266 2303499
Immobile 227.25 19.49 82 54238 527 2303238
Hepatic failure 227.11 19.49 169 54151 5520 2298245
Onychomycosis 225.36 19.49 80 54240 487 2303278
Blood parathyroid hormone decreased 225.27 19.49 64 54256 158 2303607
Body height below normal 224.12 19.49 55 54265 54 2303711
Acute lymphocytic leukaemia recurrent 223.86 19.49 64 54256 163 2303602
Paraesthesia 222.79 19.49 311 54009 21777 2281988
Hemiparesis 222.69 19.49 138 54182 3312 2300453
Osteopenia 219.35 19.49 112 54208 1823 2301942
Chronic graft versus host disease 217.20 19.49 71 54249 322 2303443
Lymphopenia 216.00 19.49 120 54200 2334 2301431
Chest pain 215.07 19.49 348 53972 27789 2275976
Neuropathy peripheral 214.77 19.49 221 54099 11211 2292554
Acute graft versus host disease in skin 214.76 19.49 71 54249 336 2303429
Blood creatinine increased 213.18 19.49 212 54108 10321 2293444
Nail disorder 212.88 19.49 93 54227 1043 2302722
Pleurisy 211.75 19.49 96 54224 1183 2302582
Cystitis 210.58 19.49 161 54159 5481 2298284
Hepatic function abnormal 210.34 19.49 166 54154 5926 2297839
Chills 210.06 19.49 253 54067 15299 2288466
Nephrolithiasis 208.80 19.49 147 54173 4396 2299369
Demyelination 208.74 19.49 88 54232 898 2302867
Oral herpes 208.50 19.49 113 54207 2089 2301676
Dyspepsia 206.41 19.49 202 54118 9642 2294123
Enthesopathy 205.49 19.49 56 54264 111 2303654
Bacterial infection 204.82 19.49 112 54208 2109 2301656
Bronchitis chronic 203.87 19.49 70 54250 380 2303385
Disseminated intravascular coagulation 203.65 19.49 129 54191 3221 2300544
Joint dislocation 202.91 19.49 97 54223 1359 2302406
Polyarthritis 201.67 19.49 83 54237 793 2302972
Respiratory disorder 201.51 19.49 137 54183 3867 2299898
Feeling abnormal 200.07 19.49 306 54014 23275 2280490
Epstein Barr virus positive mucocutaneous ulcer 198.22 19.49 45 54275 19 2303746
Aphthous ulcer 196.18 19.49 94 54226 1324 2302441
Neoplasm recurrence 196.00 19.49 67 54253 358 2303407
Coeliac disease 195.52 19.49 80 54240 752 2303013
Drug ineffective for unapproved indication 194.89 19.49 120 54200 2846 2300919
Hypercalcaemia 193.94 19.49 114 54206 2478 2301287
Myelopathy 191.04 19.49 64 54256 318 2303447
Joint laxity 188.82 19.49 43 54277 19 2303746
Seizure 187.49 19.49 303 54017 24163 2279602
Neoplasm malignant 184.96 19.49 143 54177 4950 2298815
Dry mouth 183.66 19.49 175 54145 8078 2295687
Photophobia 182.73 19.49 105 54215 2184 2301581
Agranulocytosis 182.06 19.49 122 54198 3360 2300405
Contraindication to medical treatment 181.97 19.49 54 54266 164 2303601
Graft versus host disease in skin 181.87 19.49 57 54263 219 2303546
Pyelonephritis 181.10 19.49 102 54218 2039 2301726
Bone disorder 180.97 19.49 119 54201 3173 2300592
Migraine 180.61 19.49 195 54125 10458 2293307
Foot operation 178.99 19.49 73 54247 680 2303085
Burning sensation 178.03 19.49 168 54152 7660 2296105
Progressive multifocal leukoencephalopathy 178.00 19.49 102 54218 2110 2301655
Alveolitis 177.25 19.49 63 54257 385 2303380
Cholestasis 177.06 19.49 123 54197 3598 2300167
Colitis microscopic 176.60 19.49 77 54243 859 2302906
Staphylococcal sepsis 176.51 19.49 80 54240 985 2302780
Insomnia 175.74 19.49 303 54017 25484 2278281
Carpal tunnel syndrome 175.43 19.49 98 54222 1927 2301838
Ankylosing spondylitis 173.92 19.49 70 54250 628 2303137
Secretion discharge 173.67 19.49 83 54237 1162 2302603
Ill-defined disorder 173.37 19.49 117 54203 3261 2300504
Elbow deformity 173.32 19.49 42 54278 37 2303728
Gastrooesophageal reflux disease 172.95 19.49 177 54143 8918 2294847
Histoplasmosis disseminated 172.36 19.49 52 54268 170 2303595
Foot fracture 171.80 19.49 109 54211 2729 2301036
Pustular psoriasis 170.96 19.49 74 54246 810 2302955
Dysphagia 170.76 19.49 207 54113 12598 2291167
Myalgia 169.36 19.49 282 54038 23051 2280714
Pulmonary embolism 168.16 19.49 245 54075 17838 2285927
Hyperbilirubinaemia 167.90 19.49 87 54233 1462 2302303
Deep vein thrombosis 167.50 19.49 206 54114 12726 2291039
Cutaneous vasculitis 165.58 19.49 56 54264 288 2303477
Device related infection 165.16 19.49 112 54208 3147 2300618
Drug clearance decreased 164.59 19.49 47 54273 119 2303646
Inappropriate schedule of product administration 163.90 19.49 198 54122 12006 2291759
Herpes simplex 163.81 19.49 76 54244 991 2302774
Sensitivity to weather change 163.40 19.49 60 54260 408 2303357
Intervertebral disc protrusion 162.49 19.49 108 54212 2933 2300832
Soft tissue disorder 162.30 19.49 51 54269 198 2303567
Discomfort 162.00 19.49 133 54187 5026 2298739
Disseminated tuberculosis 160.10 19.49 62 54258 497 2303268
Human antichimeric antibody positive 160.09 19.49 35 54285 7 2303758
Gastroenteritis 159.47 19.49 107 54213 2953 2300812
Tachycardia 159.42 19.49 227 54093 16182 2287583
Uveitis 159.33 19.49 85 54235 1520 2302245
Aspergillus infection 158.53 19.49 72 54248 891 2302874
Injection site pain 157.62 19.49 359 53961 37002 2266763
Nervous system disorder 155.33 19.49 106 54214 3010 2300755
Viral infection 154.11 19.49 124 54196 4552 2299213
Hypertriglyceridaemia 153.87 19.49 69 54251 827 2302938
Epicondylitis 153.62 19.49 50 54270 223 2303542
Bacteraemia 153.36 19.49 85 54235 1645 2302120
Rash pruritic 153.08 19.49 152 54168 7383 2296382
Organising pneumonia 152.54 19.49 68 54252 803 2302962
Drug tolerance decreased 152.38 19.49 50 54270 230 2303535
Oral candidiasis 151.17 19.49 88 54232 1877 2301888
Medication error 149.88 19.49 137 54183 5994 2297771
Graft versus host disease in gastrointestinal tract 149.58 19.49 49 54271 224 2303541
Mucosal ulceration 148.95 19.49 48 54272 206 2303559
Obesity 148.70 19.49 80 54240 1456 2302309
Atelectasis 148.52 19.49 87 54233 1878 2301887
X-ray abnormal 148.10 19.49 43 54277 118 2303647
Inflammatory marker increased 148.00 19.49 59 54261 515 2303250
Synovial fluid analysis 147.42 19.49 31 54289 0 2303765
Skin reaction 147.22 19.49 87 54233 1910 2301855
Aphasia 146.33 19.49 123 54197 4805 2298960
Acute lymphocytic leukaemia 146.23 19.49 56 54264 434 2303331
Crepitations 146.21 19.49 61 54259 605 2303160
Limb deformity 146.07 19.49 48 54272 222 2303543
Epistaxis 145.14 19.49 167 54153 9612 2294153
Hypoalbuminaemia 144.53 19.49 76 54244 1318 2302447
Oral mucosal exfoliation 144.34 19.49 46 54274 189 2303576
BK virus infection 144.09 19.49 49 54271 257 2303508
Scleritis 143.78 19.49 49 54271 259 2303506
Retinal toxicity 143.34 19.49 44 54276 155 2303610
Joint noise 143.23 19.49 59 54261 565 2303200
Oral disorder 143.16 19.49 76 54244 1345 2302420
Acute graft versus host disease in intestine 142.82 19.49 46 54274 197 2303568
Memory impairment 142.39 19.49 190 54130 12733 2291032
Loss of consciousness 141.80 19.49 231 54089 18536 2285229
Drug level increased 141.76 19.49 96 54224 2691 2301074
Still's disease 141.58 19.49 40 54280 96 2303669
Hepatic enzyme abnormal 141.31 19.49 60 54260 624 2303141
Ascites 140.16 19.49 127 54193 5493 2298272
Productive cough 140.13 19.49 124 54196 5197 2298568
Cytopenia 139.93 19.49 67 54253 942 2302823
Night sweats 139.73 19.49 104 54216 3396 2300369
Hepatitis B 138.90 19.49 63 54257 777 2302988
Lung neoplasm malignant 138.78 19.49 98 54222 2944 2300821
Rheumatoid lung 138.14 19.49 42 54278 142 2303623
Gastritis 137.39 19.49 115 54205 4466 2299299
Gastric ulcer 137.21 19.49 97 54223 2919 2300846
Abdominal distension 136.68 19.49 167 54153 10244 2293521
International normalised ratio fluctuation 136.49 19.49 48 54272 283 2303482
Skin disorder 136.33 19.49 104 54216 3527 2300238
Metastasis 136.10 19.49 64 54256 862 2302903
Hepatic fibrosis 135.73 19.49 55 54265 503 2303262
Pancreatitis 135.38 19.49 147 54173 7932 2295833
Folate deficiency 135.25 19.49 43 54277 175 2303590
Breast cancer stage III 134.18 19.49 40 54280 124 2303641
Limb discomfort 134.00 19.49 100 54220 3279 2300486
Antinuclear antibody positive 132.51 19.49 66 54254 1016 2302749
Lung infiltration 132.18 19.49 85 54235 2179 2301586
Presbyacusis 132.15 19.49 32 54288 28 2303737
Facial paralysis 131.88 19.49 87 54233 2332 2301433
Helicobacter infection 131.17 19.49 55 54265 553 2303212
Lupus-like syndrome 131.08 19.49 81 54239 1933 2301832
Atrial fibrillation 130.10 19.49 188 54132 13580 2290185
Blood culture positive 129.80 19.49 58 54262 689 2303076
Blister 129.13 19.49 132 54188 6639 2297126
Bone density decreased 128.85 19.49 70 54250 1300 2302465
Bedridden 128.69 19.49 71 54249 1361 2302404
Hepatomegaly 128.63 19.49 77 54243 1732 2302033
Bronchopulmonary aspergillosis 128.18 19.49 63 54257 941 2302824
Pseudomonas infection 127.85 19.49 66 54254 1100 2302665
Pleuritic pain 127.54 19.49 55 54265 596 2303169
Adrenal insufficiency 127.43 19.49 70 54250 1330 2302435
Spinal pain 127.27 19.49 69 54251 1276 2302489
Erysipelas 127.06 19.49 63 54257 960 2302805
Rhinorrhoea 126.61 19.49 137 54183 7363 2296402
Pericarditis 126.56 19.49 72 54248 1468 2302297
Human herpesvirus 6 infection 126.34 19.49 47 54273 333 2303432
Skin erosion 125.56 19.49 48 54272 370 2303395
Osteomyelitis 125.40 19.49 99 54221 3534 2300231
Hypoxia 125.35 19.49 125 54195 6102 2297663
Type 2 diabetes mellitus 124.72 19.49 81 54239 2113 2301652
Gastrointestinal toxicity 123.04 19.49 52 54268 534 2303231
Iron deficiency anaemia 123.03 19.49 79 54241 2020 2301745
Cardiac failure 122.92 19.49 171 54149 11923 2291842
Hypersensitivity pneumonitis 122.23 19.49 48 54272 401 2303364
Pleural fibrosis 122.03 19.49 39 54281 162 2303603
Anaemia macrocytic 121.07 19.49 46 54274 348 2303417
Urosepsis 119.69 19.49 76 54244 1905 2301860
Tenosynovitis stenosans 119.52 19.49 35 54285 100 2303665
Hepatitis E 118.31 19.49 38 54282 161 2303604
Anxiety 118.14 19.49 277 54043 29082 2274683
Diarrhoea haemorrhagic 117.72 19.49 66 54254 1307 2302458
Accidental overdose 117.64 19.49 99 54221 3873 2299892
Non-alcoholic steatohepatitis 117.02 19.49 38 54282 168 2303597
Feeding disorder 116.69 19.49 67 54253 1391 2302374
Amnesia 116.37 19.49 129 54191 7124 2296641
Clostridium difficile colitis 116.33 19.49 76 54244 2003 2301762
Liver injury 116.01 19.49 79 54241 2235 2301530
Conjunctivitis 115.95 19.49 80 54240 2313 2301452
Unevaluable event 115.70 19.49 142 54178 8749 2295016
Clostridium difficile infection 115.65 19.49 86 54234 2804 2300961
Visceral leishmaniasis 115.61 19.49 31 54289 56 2303709
Immune system disorder 115.38 19.49 66 54254 1360 2302405
Pneumonia bacterial 115.24 19.49 58 54262 914 2302851
Transaminases abnormal 114.88 19.49 33 54287 86 2303679
Gastrointestinal haemorrhage 114.87 19.49 168 54152 12267 2291498
Thyroid disorder 114.57 19.49 68 54252 1505 2302260
Arthrodesis 113.72 19.49 38 54282 187 2303578
Neck mass 113.44 19.49 43 54277 323 2303442
Back injury 113.26 19.49 57 54263 898 2302867
Neck deformity 112.67 19.49 30 54290 52 2303713
Tumour lysis syndrome 112.57 19.49 59 54261 1016 2302749
Haemorrhage 112.06 19.49 156 54164 10883 2292882
Histoplasmosis 111.87 19.49 41 54279 277 2303488
Ankle deformity 111.67 19.49 29 54291 43 2303722
Aplasia 111.62 19.49 46 54274 441 2303324
Arthritis infective 111.52 19.49 50 54270 599 2303166
Epstein-Barr viraemia 111.25 19.49 33 54287 100 2303665
Neutrophil count decreased 110.92 19.49 120 54200 6447 2297318
SLE arthritis 110.91 19.49 30 54290 57 2303708
Wheezing 110.19 19.49 118 54202 6266 2297499
Viral upper respiratory tract infection 109.22 19.49 58 54262 1027 2302738
Hepatosplenomegaly 109.14 19.49 45 54275 432 2303333
Pneumothorax 108.99 19.49 76 54244 2236 2301529
Blood bilirubin increased 108.88 19.49 108 54212 5237 2298528
Femur fracture 108.36 19.49 120 54200 6619 2297146
Mucosal toxicity 108.29 19.49 29 54291 52 2303713
Lethargy 108.10 19.49 136 54184 8594 2295171
JC virus infection 108.10 19.49 36 54284 175 2303590
Dermatitis 107.01 19.49 76 54244 2304 2301461
Onychomadesis 106.92 19.49 45 54275 457 2303308
Central nervous system lymphoma 106.46 19.49 36 54284 185 2303580
Epidermal necrosis 106.43 19.49 34 54286 141 2303624
Joint arthroplasty 106.42 19.49 42 54278 356 2303409
Dehydration 106.15 19.49 225 54095 22070 2281695
Invasive ductal breast carcinoma 106.12 19.49 54 54266 872 2302893
Cytomegalovirus viraemia 106.02 19.49 44 54276 430 2303335
Photosensitivity reaction 105.67 19.49 76 54244 2351 2301414
Rotator cuff syndrome 105.27 19.49 68 54252 1757 2302008
Hypogammaglobulinaemia 105.24 19.49 50 54270 690 2303075
Respiratory distress 105.16 19.49 104 54216 5025 2298740
Palpitations 105.09 19.49 188 54132 16268 2287497
Toxic epidermal necrolysis 104.93 19.49 84 54236 3060 2300705
Myocardial infarction 103.69 19.49 203 54117 18810 2284955
Hypokalaemia 102.87 19.49 147 54173 10507 2293258
Splenomegaly 102.52 19.49 63 54257 1488 2302277
Body temperature increased 102.18 19.49 83 54237 3088 2300677
Tooth abscess 101.91 19.49 70 54250 2009 2301756
Rheumatoid factor negative 101.82 19.49 22 54298 3 2303762
Pain in jaw 101.65 19.49 113 54207 6259 2297506
Mucormycosis 101.26 19.49 41 54279 374 2303391
Pleural thickening 100.97 19.49 28 54292 61 2303704
Pericardial effusion 100.75 19.49 91 54229 3918 2299847
Swelling face 100.64 19.49 137 54183 9356 2294409
Deafness neurosensory 100.42 19.49 44 54276 497 2303268
Incorrect dosage administered 100.34 19.49 40 54280 349 2303416
Chronic graft versus host disease in skin 99.92 19.49 27 54293 51 2303714
Scar 99.81 19.49 67 54253 1850 2301915
Wound infection 99.71 19.49 58 54262 1235 2302530
Radiculopathy 99.66 19.49 48 54272 684 2303081
Mucocutaneous ulceration 99.65 19.49 24 54296 20 2303745
Wrist surgery 99.13 19.49 31 54289 118 2303647
Asthma 98.96 19.49 149 54171 11165 2292600
Enterobacter infection 98.89 19.49 36 54284 238 2303527
Nephropathy toxic 98.85 19.49 56 54264 1132 2302633
Haematuria 98.79 19.49 93 54227 4225 2299540
Cyst 98.45 19.49 62 54258 1531 2302234
Vaginal haemorrhage 98.45 19.49 99 54221 4881 2298884
Eye pain 98.10 19.49 98 54222 4793 2298972
Polyneuropathy 97.55 19.49 64 54256 1699 2302066
Wheelchair user 97.36 19.49 41 54279 417 2303348
Pulmonary haemorrhage 97.25 19.49 56 54264 1169 2302596
Ear pain 97.22 19.49 76 54244 2673 2301092
Mycobacterium tuberculosis complex test positive 97.01 19.49 40 54280 384 2303381
Metastases to liver 96.92 19.49 78 54242 2863 2300902
Oedema peripheral 96.45 19.49 225 54095 23538 2280227
Exostosis 96.28 19.49 58 54262 1320 2302445
Synovial disorder 96.13 19.49 28 54292 78 2303687
Squamous cell carcinoma 96.09 19.49 58 54262 1325 2302440
Venoocclusive disease 95.94 19.49 35 54285 233 2303532
Pancreatitis acute 95.93 19.49 87 54233 3766 2299999
Tooth infection 95.84 19.49 66 54254 1902 2301863
Renal disorder 95.73 19.49 93 54227 4395 2299370
Complications of bone marrow transplant 95.51 19.49 25 54295 39 2303726
White blood cell count increased 95.27 19.49 115 54205 6963 2296802
Intervertebral discitis 94.67 19.49 36 54284 273 2303492
Nerve injury 94.28 19.49 53 54267 1055 2302710
Leukaemia recurrent 94.28 19.49 34 54286 218 2303547
Spinal column injury 94.01 19.49 34 54286 220 2303545
Lennox-Gastaut syndrome 93.83 19.49 22 54298 14 2303751
Colitis ulcerative 93.80 19.49 75 54245 2727 2301038
Chronic obstructive pulmonary disease 93.65 19.49 114 54206 6963 2296802
Cystitis haemorrhagic 93.60 19.49 44 54276 592 2303173
Impaired gastric emptying 93.27 19.49 50 54270 903 2302862
Chronic kidney disease 92.88 19.49 88 54232 4030 2299735
Injection site bruising 92.86 19.49 151 54169 12092 2291673
Vertigo 92.85 19.49 131 54189 9253 2294512
Malignant neoplasm progression 92.55 19.49 150 54170 11978 2291787
Bacterial sepsis 91.59 19.49 40 54280 448 2303317
Sarcoidosis 91.04 19.49 48 54272 837 2302928
Skin infection 91.03 19.49 57 54263 1393 2302372
Acute respiratory failure 90.54 19.49 76 54244 2962 2300803
Surgical failure 90.07 19.49 28 54292 104 2303661
Abscess 89.87 19.49 69 54251 2362 2301403
Nonalcoholic fatty liver disease 89.84 19.49 23 54297 31 2303734
Blood lactate dehydrogenase increased 89.36 19.49 80 54240 3404 2300361
Blood pressure fluctuation 89.24 19.49 62 54258 1813 2301952
Subcutaneous abscess 88.80 19.49 48 54272 882 2302883
Wrist deformity 88.60 19.49 26 54294 75 2303690
Peritonitis 88.53 19.49 70 54250 2504 2301261
Red blood cell count decreased 88.38 19.49 87 54233 4179 2299586
Mouth haemorrhage 87.81 19.49 49 54271 961 2302804
Muscle spasms 87.30 19.49 204 54116 21362 2282403
Hepatitis B reactivation 87.15 19.49 33 54287 247 2303518
Hepatosplenic T-cell lymphoma 87.06 19.49 23 54297 38 2303727
Red blood cell sedimentation rate 87.03 19.49 20 54300 10 2303755
Klebsiella infection 86.00 19.49 45 54275 772 2302993
Fungaemia 85.98 19.49 32 54288 227 2303538
Appendicitis 85.79 19.49 51 54269 1132 2302633
Viraemia 85.48 19.49 27 54293 107 2303658
Confusional state 85.47 19.49 218 54102 24126 2279639
Neoplasm progression 85.39 19.49 89 54231 4579 2299186
Pharyngeal oedema 85.26 19.49 78 54242 3415 2300350
Skin papilloma 84.91 19.49 40 54280 541 2303224
Abdominal pain lower 84.59 19.49 72 54248 2861 2300904
Therapy cessation 84.40 19.49 93 54227 5100 2298665
Adult T-cell lymphoma/leukaemia 84.32 19.49 27 54293 113 2303652
Walking aid user 84.24 19.49 43 54277 699 2303066
Musculoskeletal deformity 83.96 19.49 20 54300 15 2303750
Dactylitis 83.74 19.49 25 54295 78 2303687
Bone density abnormal 83.40 19.49 36 54284 391 2303374
Cutaneous T-cell lymphoma 82.68 19.49 33 54287 289 2303476
Cerebral toxoplasmosis 82.52 19.49 26 54294 102 2303663
Meningitis 82.02 19.49 48 54272 1034 2302731
Exposure during pregnancy 81.55 19.49 219 54101 25000 2278765
Osteonecrosis 80.93 19.49 108 54212 7234 2296531
Skin mass 80.91 19.49 47 54273 998 2302767
Blood test abnormal 80.71 19.49 51 54269 1267 2302498
Pseudomonas test positive 80.61 19.49 27 54293 134 2303631
Epigastric discomfort 80.53 19.49 38 54282 516 2303249
Oedema 80.32 19.49 128 54192 10075 2293690
Haematocrit decreased 80.19 19.49 83 54237 4235 2299530
Mycobacterial infection 79.88 19.49 31 54289 250 2303515
Thyroid neoplasm 79.83 19.49 40 54280 624 2303141
Musculoskeletal discomfort 79.73 19.49 61 54259 2077 2301688
Spinal disorder 79.59 19.49 49 54271 1161 2302604
Blood disorder 79.20 19.49 45 54275 915 2302850
Upper limb fracture 78.85 19.49 67 54253 2656 2301109
Enterococcal infection 78.01 19.49 41 54279 710 2303055
Enterococcal bacteraemia 77.80 19.49 26 54294 128 2303637
Lyme disease 77.75 19.49 34 54286 382 2303383
Multiple allergies 77.57 19.49 43 54277 832 2302933
Gamma-glutamyltransferase increased 77.53 19.49 92 54228 5470 2298295
Secondary immunodeficiency 77.46 19.49 23 54297 70 2303695
Rectal cancer 77.44 19.49 34 54286 386 2303379
Bone marrow toxicity 77.39 19.49 33 54287 347 2303418
Clostridium test positive 77.22 19.49 31 54289 276 2303489
Dysphonia 76.97 19.49 98 54222 6266 2297499
Lung adenocarcinoma 76.93 19.49 40 54280 677 2303088
Escherichia urinary tract infection 76.92 19.49 49 54271 1235 2302530
Lower limb fracture 76.79 19.49 59 54261 2022 2301743
Generalised tonic-clonic seizure 76.78 19.49 90 54230 5282 2298483
Thrombosis 76.54 19.49 118 54202 9026 2294739
Lip ulceration 76.48 19.49 29 54291 218 2303547
Nasal ulcer 76.45 19.49 30 54290 250 2303515
Treatment noncompliance 76.26 19.49 91 54229 5443 2298322
Extremity contracture 76.21 19.49 24 54296 94 2303671
Dysarthria 76.15 19.49 97 54223 6205 2297560
Hyperhidrosis 76.13 19.49 158 54162 15264 2288501
Foetal methotrexate syndrome 76.09 19.49 16 54304 0 2303765
Ileus paralytic 75.77 19.49 41 54279 755 2303010
Pneumonia legionella 75.69 19.49 29 54291 225 2303540
Hypergammaglobulinaemia benign monoclonal 75.61 19.49 24 54296 97 2303668
Blood albumin decreased 75.39 19.49 55 54265 1740 2302025
Vasculitis 75.37 19.49 61 54259 2257 2301508
Post procedural infection 75.09 19.49 46 54274 1080 2302685
Skin atrophy 75.04 19.49 38 54282 607 2303158
Growth failure 74.99 19.49 20 54300 35 2303730
Nasal congestion 74.54 19.49 101 54219 6865 2296900
Candida test positive 74.47 19.49 24 54296 103 2303662
Shock 74.42 19.49 77 54243 3927 2299838
Constipation 74.17 19.49 192 54128 21437 2282328
Spinal osteoarthritis 74.17 19.49 54 54266 1703 2302062
Paralysis 74.06 19.49 55 54265 1789 2301976
Mycobacterium avium complex infection 73.92 19.49 33 54287 391 2303374
Intentional product use issue 73.77 19.49 73 54247 3529 2300236
Osteosclerosis 73.55 19.49 31 54289 316 2303449
Odynophagia 73.36 19.49 43 54277 929 2302836
Poor quality sleep 73.09 19.49 56 54264 1911 2301854
Coagulopathy 73.04 19.49 66 54254 2843 2300922
Traumatic lung injury 72.94 19.49 30 54290 286 2303479
Investigation abnormal 72.67 19.49 22 54298 73 2303692
Obliterative bronchiolitis 72.67 19.49 28 54292 221 2303544
Petechiae 72.66 19.49 57 54263 2015 2301750
Sacroiliitis 72.55 19.49 29 54291 255 2303510
Rash erythematous 72.24 19.49 92 54228 5884 2297881
Temporal lobe epilepsy 72.22 19.49 22 54298 75 2303690
Necrosis 72.11 19.49 43 54277 960 2302805
Tonsillitis 72.05 19.49 41 54279 836 2302929
Osteoporotic fracture 72.04 19.49 31 54289 334 2303431
Hyperlipidaemia 71.76 19.49 63 54257 2611 2301154
Acute promyelocytic leukaemia 71.70 19.49 28 54292 230 2303535
Neuroendocrine carcinoma of the skin 71.50 19.49 23 54297 98 2303667
Surgery 71.36 19.49 88 54232 5447 2298318
Haematochezia 71.21 19.49 86 54234 5209 2298556
Limb operation 70.89 19.49 35 54285 528 2303237
Spinal fracture 70.86 19.49 64 54256 2755 2301010
Paraplegia 70.75 19.49 34 54286 482 2303283
Whipple's disease 70.00 19.49 18 54302 25 2303740
Skin cancer 69.82 19.49 52 54268 1699 2302066
Streptococcal infection 69.80 19.49 40 54280 827 2302938
Pneumonia cryptococcal 69.49 19.49 22 54298 88 2303677
Plasmablastic lymphoma 68.95 19.49 19 54301 40 2303725
Dislocation of vertebra 68.91 19.49 22 54298 91 2303674
Gingival bleeding 68.77 19.49 55 54265 2000 2301765
Syncope 68.69 19.49 160 54160 16715 2287050
Flank pain 68.68 19.49 49 54271 1496 2302269
Encephalitis viral 68.51 19.49 26 54294 196 2303569
Idiopathic pneumonia syndrome 68.15 19.49 17 54303 19 2303746
Metastases to lung 68.12 19.49 51 54269 1680 2302085
Laboratory test abnormal 68.03 19.49 84 54236 5206 2298559
Abortion spontaneous 67.84 19.49 139 54181 13306 2290459
Functional gastrointestinal disorder 67.58 19.49 32 54288 438 2303327
Thrombotic microangiopathy 67.55 19.49 46 54274 1301 2302464
Extranodal marginal zone B-cell lymphoma (MALT type) 67.25 19.49 22 54298 100 2303665
Drug specific antibody 67.09 19.49 20 54300 62 2303703
Jaundice 66.90 19.49 85 54235 5423 2298342
Neurological symptom 66.80 19.49 40 54280 900 2302865
Mycobacterium chelonae infection 66.73 19.49 21 54299 82 2303683
Fungal skin infection 66.66 19.49 33 54287 501 2303264
Toxic encephalopathy 66.56 19.49 38 54282 780 2302985
Bone cyst 66.53 19.49 24 54296 154 2303611
Cholelithiasis 66.49 19.49 87 54233 5716 2298049
Emphysema 66.48 19.49 42 54278 1043 2302722
Retinitis 66.38 19.49 20 54300 65 2303700
Meningoencephalitis herpetic 66.22 19.49 26 54294 217 2303548
Metastases to bone 66.05 19.49 56 54264 2213 2301552
Guillain-Barre syndrome 65.74 19.49 35 54285 623 2303142
Iron deficiency 65.41 19.49 34 54286 575 2303190
Bicytopenia 65.41 19.49 26 54294 225 2303540
Somnolence 65.20 19.49 193 54127 23292 2280473
Hair follicle tumour benign 65.05 19.49 16 54304 16 2303749
Pseudomonal sepsis 65.04 19.49 27 54293 264 2303501
Skin discolouration 64.82 19.49 83 54237 5337 2298428
Impaired quality of life 64.76 19.49 24 54296 168 2303597
Escherichia sepsis 64.73 19.49 33 54287 535 2303230
Wernicke's encephalopathy 64.69 19.49 19 54301 55 2303710
Intervertebral disc degeneration 64.64 19.49 48 54272 1561 2302204
Systemic candida 64.63 19.49 28 54292 307 2303458
Bursitis infective 64.60 19.49 20 54300 73 2303692
Stress fracture 64.59 19.49 44 54276 1245 2302520
Cerebral infarction 64.51 19.49 75 54245 4362 2299403
Ulcerative keratitis 64.51 19.49 33 54287 539 2303226
Poor venous access 64.50 19.49 38 54282 829 2302936
Haematemesis 64.43 19.49 72 54248 4010 2299755
Cerebral venous sinus thrombosis 64.19 19.49 29 54291 354 2303411
Rheumatic disorder 63.57 19.49 24 54296 178 2303587
Cerebral venous thrombosis 63.53 19.49 30 54290 408 2303357
Irritable bowel syndrome 63.17 19.49 50 54270 1791 2301974
Viral vasculitis 63.12 19.49 15 54305 11 2303754
Toe operation 62.94 19.49 22 54298 127 2303638
Vitamin D deficiency 62.70 19.49 46 54274 1468 2302297
Platelet count increased 62.65 19.49 54 54266 2183 2301582
Staphylococcal bacteraemia 62.56 19.49 33 54287 576 2303189
Breast mass 62.27 19.49 41 54279 1095 2302670
Hypercholesterolaemia 62.18 19.49 47 54273 1571 2302194
Mucosal disorder 62.13 19.49 30 54290 430 2303335
Renal cancer 61.70 19.49 34 54286 650 2303115
Bone pain 61.59 19.49 106 54214 8890 2294875
Vascular access complication 61.30 19.49 21 54299 113 2303652
Post transplant lymphoproliferative disorder 61.28 19.49 31 54289 494 2303271
Strongyloidiasis 61.22 19.49 23 54297 168 2303597
Endocarditis 60.97 19.49 35 54285 726 2303039
Rhinovirus infection 60.02 19.49 26 54294 285 2303480
Escherichia bacteraemia 59.95 19.49 27 54293 327 2303438
Pneumonia haemophilus 59.86 19.49 18 54302 58 2303707
Blood magnesium increased 59.85 19.49 22 54298 150 2303615
Mental status changes 59.82 19.49 81 54239 5501 2298264
Skin toxicity 59.76 19.49 35 54285 755 2303010
Meningitis aseptic 59.46 19.49 33 54287 640 2303125
Accident 59.27 19.49 36 54284 832 2302933
Infection reactivation 59.11 19.49 20 54300 103 2303662
Mesenteritis 59.06 19.49 14 54306 10 2303755
Pyelonephritis acute 58.97 19.49 31 54289 537 2303228
Herpes virus infection 58.96 19.49 36 54284 840 2302925
Lung consolidation 58.10 19.49 30 54290 500 2303265
Physical disability 58.06 19.49 22 54298 165 2303600
Antibody test positive 57.96 19.49 25 54295 271 2303494
Respiratory symptom 57.46 19.49 23 54297 203 2303562
Neuralgia 57.43 19.49 57 54263 2765 2301000
Mass 57.38 19.49 47 54273 1769 2301996
Gastroenteritis viral 56.86 19.49 54 54266 2480 2301285
Toothache 56.78 19.49 55 54265 2589 2301176
Tibia fracture 56.62 19.49 34 54286 769 2302996
Hot flush 56.22 19.49 90 54230 7109 2296656
Ovarian neoplasm 56.20 19.49 22 54298 182 2303583
Hypothyroidism 56.07 19.49 70 54250 4387 2299378
Epstein-Barr virus test positive 56.02 19.49 20 54300 124 2303641
Bronchial carcinoma 55.89 19.49 20 54300 125 2303640
Breast cancer recurrent 55.77 19.49 33 54287 726 2303039
Disease susceptibility 55.62 19.49 15 54305 28 2303737
Isosporiasis 55.61 19.49 13 54307 8 2303757
Hyperglycaemia 55.59 19.49 73 54247 4812 2298953
Back disorder 55.54 19.49 44 54276 1578 2302187
Synostosis 55.50 19.49 14 54306 17 2303748
Hepatitis acute 55.50 19.49 43 54277 1492 2302273
Sleep disorder due to general medical condition, insomnia type 55.49 19.49 26 54294 347 2303418
Empyema 55.41 19.49 24 54296 263 2303502
Metastases to lymph nodes 55.25 19.49 36 54284 944 2302821
Crying 55.23 19.49 69 54251 4327 2299438
Pharyngitis streptococcal 55.10 19.49 43 54277 1508 2302257
Arachnoiditis 55.05 19.49 19 54301 105 2303660
Trichodysplasia spinulosa 54.56 19.49 16 54304 46 2303719
Kidney infection 54.35 19.49 53 54267 2516 2301249
Anal incontinence 54.19 19.49 45 54275 1727 2302038
Sinusitis fungal 53.96 19.49 18 54302 88 2303677
Gastrointestinal infection 53.85 19.49 37 54283 1062 2302703
Ataxia 53.82 19.49 52 54268 2440 2301325
Intestinal perforation 53.77 19.49 45 54275 1746 2302019
Hyperkeratosis 53.67 19.49 33 54287 780 2302985
Acute interstitial pneumonitis 53.47 19.49 18 54302 91 2303674
No adverse event 53.47 19.49 103 54217 9425 2294340
Quality of life decreased 53.40 19.49 32 54288 721 2303044
Eye haemorrhage 53.28 19.49 40 54280 1323 2302442
Keratopathy 52.99 19.49 18 54302 94 2303671
Diverticular perforation 52.78 19.49 27 54293 441 2303324
Breast cancer female 52.58 19.49 40 54280 1350 2302415
Cell death 52.36 19.49 25 54295 349 2303416
Chest X-ray abnormal 52.27 19.49 30 54290 622 2303143
Cervical dysplasia 51.99 19.49 31 54289 692 2303073
Takayasu's arteritis 51.84 19.49 17 54303 78 2303687
Folliculitis 51.82 19.49 29 54291 572 2303193
Generalised oedema 51.63 19.49 50 54270 2353 2301412
Varicella 51.61 19.49 25 54295 361 2303404
Gastrointestinal inflammation 51.55 19.49 31 54289 703 2303062
Pyomyositis 51.44 19.49 15 54305 42 2303723
Brain oedema 51.40 19.49 49 54271 2261 2301504
Antithrombin III 51.35 19.49 11 54309 1 2303764
Bone marrow disorder 51.30 19.49 25 54295 366 2303399
Gastroenteritis norovirus 51.29 19.49 22 54298 235 2303530
Quadriplegia 51.12 19.49 25 54295 369 2303396
Cryptococcosis 51.02 19.49 19 54301 135 2303630
Oesophageal candidiasis 51.02 19.49 30 54290 652 2303113
Pneumocystis jirovecii infection 50.98 19.49 21 54299 201 2303564
Human bocavirus infection 50.96 19.49 12 54308 8 2303757
Neutropenic colitis 50.89 19.49 23 54297 281 2303484
Tongue ulceration 50.79 19.49 27 54293 479 2303286
Toe amputation 50.52 19.49 24 54296 331 2303434
Atypical mycobacterial infection 50.35 19.49 21 54299 208 2303557
Respiratory tract congestion 50.26 19.49 49 54271 2325 2301440
Cholecystitis acute 50.09 19.49 36 54284 1112 2302653
Colon cancer 50.00 19.49 44 54276 1829 2301936
Epstein-Barr virus associated lymphoma 49.96 19.49 15 54305 48 2303717
Anterior chamber cleavage syndrome 49.82 19.49 12 54308 10 2303755
Systemic inflammatory response syndrome 49.78 19.49 31 54289 750 2303015
Abscess limb 49.60 19.49 28 54292 562 2303203
Skin fissures 49.54 19.49 37 54283 1214 2302551
Glioma 49.40 19.49 16 54304 70 2303695
Leukaemia 49.38 19.49 31 54289 761 2303004
Bladder cancer 49.36 19.49 30 54290 694 2303071
Lymph node tuberculosis 49.34 19.49 20 54300 183 2303582
Depressed mood 49.11 19.49 71 54249 5127 2298638
Tachypnoea 49.06 19.49 47 54273 2182 2301583
Vision blurred 49.03 19.49 129 54191 14539 2289226
Blindness 49.03 19.49 59 54261 3559 2300206
Cholecystitis 48.86 19.49 47 54273 2193 2301572
Fibrosis 48.77 19.49 26 54294 464 2303301
Cardiomyopathy 48.63 19.49 52 54268 2755 2301010
Keratitis 48.59 19.49 27 54293 525 2303240
Acne 48.39 19.49 55 54265 3121 2300644
Tinnitus 48.31 19.49 70 54250 5065 2298700
Perineal necrosis 48.20 19.49 11 54309 5 2303760
Growth retardation 48.18 19.49 21 54299 234 2303531
Vasculitic rash 48.04 19.49 19 54301 162 2303603
Granuloma 48.01 19.49 28 54292 599 2303166
Chloroma 47.98 19.49 15 54305 57 2303708
Bloody discharge 47.97 19.49 18 54302 131 2303634
Bone swelling 47.96 19.49 20 54300 198 2303567
Embolism 47.95 19.49 37 54283 1276 2302489
Hiatus hernia 47.88 19.49 45 54275 2039 2301726
Oxygen saturation decreased 47.55 19.49 86 54234 7500 2296265
Cytomegalovirus colitis 47.54 19.49 22 54298 285 2303480
Temperature intolerance 47.52 19.49 33 54287 964 2302801
Serum ferritin increased 47.47 19.49 31 54289 816 2302949
Angioedema 47.40 19.49 91 54229 8305 2295460
Superior sagittal sinus thrombosis 47.34 19.49 19 54301 169 2303596
Necrotising fasciitis 47.32 19.49 26 54294 494 2303271
Anal abscess 47.17 19.49 27 54293 557 2303208
Escherichia infection 47.09 19.49 37 54283 1311 2302454
Acute graft versus host disease in liver 46.87 19.49 17 54303 111 2303654
Mean cell haemoglobin decreased 46.58 19.49 21 54299 255 2303510
Oral mucosal blistering 46.49 19.49 31 54289 846 2302919
Bunion operation 46.40 19.49 18 54302 145 2303620
Hypermobility syndrome 46.36 19.49 13 54307 30 2303735
Product prescribing error 46.36 19.49 52 54268 2908 2300857
Intervertebral disc compression 46.29 19.49 18 54302 146 2303619
Incorrect dose administered 46.29 19.49 98 54222 9597 2294168
Eating disorder 46.28 19.49 46 54274 2235 2301530
Staphylococcus test positive 46.26 19.49 25 54295 459 2303306
Goitre 46.11 19.49 31 54289 858 2302907
Myelitis 46.08 19.49 21 54299 262 2303503
Eye infection 46.00 19.49 36 54284 1268 2302497
Breath sounds abnormal 45.80 19.49 29 54291 723 2303042
Joint warmth 45.79 19.49 21 54299 266 2303499
Ovarian cancer 45.78 19.49 36 54284 1277 2302488
Choriocarcinoma 45.76 19.49 11 54309 9 2303756
Chronic lymphocytic leukaemia 45.74 19.49 26 54294 529 2303236
Perineal infection 45.74 19.49 12 54308 19 2303746
Kaposi's sarcoma 45.72 19.49 21 54299 267 2303498
Myelitis transverse 45.71 19.49 20 54300 225 2303540
Ewing's sarcoma 45.67 19.49 14 54306 49 2303716
Autoimmune hepatitis 45.62 19.49 40 54280 1655 2302110
Laryngeal disorder 45.40 19.49 16 54304 95 2303670
Eczema herpeticum 45.36 19.49 12 54308 20 2303745
Enterocolitis 45.27 19.49 30 54290 810 2302955
Coma 44.94 19.49 93 54227 8963 2294802
Skin exfoliation 44.69 19.49 72 54248 5718 2298047
Mean cell volume decreased 44.65 19.49 20 54300 239 2303526
Intervertebral disc space narrowing 44.57 19.49 16 54304 101 2303664
Soft tissue infection 44.49 19.49 22 54298 333 2303432
Lipase increased 44.44 19.49 37 54283 1425 2302340
Restrictive pulmonary disease 44.38 19.49 18 54302 165 2303600
Limb injury 44.37 19.49 47 54273 2463 2301302
Cerebrovascular accident 44.26 19.49 153 54167 20033 2283732
Pulmonary nocardiosis 44.23 19.49 11 54309 12 2303753
Rash pustular 44.23 19.49 38 54282 1529 2302236
Red cell distribution width decreased 44.03 19.49 14 54306 57 2303708
Cytomegalovirus chorioretinitis 44.00 19.49 18 54302 169 2303596
Dyspnoea exertional 43.97 19.49 71 54249 5649 2298116
Ototoxicity 43.85 19.49 20 54300 250 2303515
Nodular melanoma 43.77 19.49 11 54309 13 2303752
Latent tuberculosis 43.74 19.49 21 54299 297 2303468
Dermatitis bullous 43.53 19.49 37 54283 1467 2302298
Tendonitis 43.51 19.49 44 54276 2183 2301582
Drug dependence 43.48 19.49 51 54269 2994 2300771
Venous thrombosis 43.47 19.49 29 54291 792 2302973
Aspiration bone marrow abnormal 43.31 19.49 12 54308 26 2303739
Aplastic anaemia 43.27 19.49 30 54290 874 2302891
Motor dysfunction 43.24 19.49 34 54286 1206 2302559
Tendon rupture 43.23 19.49 37 54283 1481 2302284
Delirium 43.14 19.49 67 54253 5156 2298609
Partial seizures 43.03 19.49 30 54290 882 2302883
Feeling jittery 43.02 19.49 41 54279 1891 2301874
Stem cell transplant 42.97 19.49 22 54298 360 2303405
Enteritis 42.74 19.49 32 54288 1054 2302711
Gastrointestinal necrosis 42.61 19.49 26 54294 606 2303159
Hypertensive crisis 42.56 19.49 46 54274 2467 2301298
Ophthalmic herpes zoster 42.46 19.49 21 54299 318 2303447
Embolism venous 42.35 19.49 21 54299 320 2303445
Non-small cell lung cancer 42.33 19.49 25 54295 548 2303217
Pleocytosis 42.29 19.49 15 54305 91 2303674
Pneumonia pneumococcal 42.22 19.49 20 54300 274 2303491
West Nile viral infection 42.09 19.49 13 54307 47 2303718
Combined immunodeficiency 42.09 19.49 11 54309 17 2303748
Papillary thyroid cancer 42.06 19.49 22 54298 377 2303388
Macrocytosis 42.05 19.49 19 54301 232 2303533
Extrapulmonary tuberculosis 41.88 19.49 13 54307 48 2303717
Pulmonary oedema 41.81 19.49 80 54240 7283 2296482
Blood pressure systolic increased 41.71 19.49 44 54276 2295 2301470
Laryngitis fungal 41.70 19.49 11 54309 18 2303747
Pneumonia cytomegaloviral 41.65 19.49 20 54300 283 2303482
Rhinitis 41.63 19.49 32 54288 1097 2302668
Rebound effect 41.60 19.49 26 54294 633 2303132
Dysstasia 41.59 19.49 49 54271 2890 2300875
Systemic lupus erythematosus rash 41.58 19.49 18 54302 197 2303568
Systemic mycosis 41.45 19.49 16 54304 127 2303638
Angina pectoris 41.43 19.49 57 54263 3930 2299835
Rectal haemorrhage 41.40 19.49 70 54250 5786 2297979
Bronchopleural fistula 41.26 19.49 13 54307 51 2303714
Sleep disorder due to a general medical condition 41.21 19.49 21 54299 340 2303425
Increased tendency to bruise 41.19 19.49 37 54283 1581 2302184
Malignant neoplasm of conjunctiva 41.16 19.49 10 54310 9 2303756
Infiltration anaesthesia 41.00 19.49 9 54311 2 2303763
Oral mucosa erosion 41.00 19.49 19 54301 247 2303518
Fungal sepsis 40.97 19.49 17 54303 166 2303599
Ocular toxicity 40.97 19.49 15 54305 101 2303664
Enterococcus test positive 40.91 19.49 16 54304 132 2303633
Ileus 40.78 19.49 42 54278 2130 2301635
Cachexia 40.77 19.49 28 54292 803 2302962
Hyperammonaemia 40.74 19.49 28 54292 804 2302961
Abnormal loss of weight 40.68 19.49 26 54294 659 2303106
Ocular hyperaemia 40.67 19.49 57 54263 3999 2299766
Heart rate increased 40.57 19.49 101 54219 11004 2292761
Tumour necrosis 40.53 19.49 17 54303 171 2303594
Mean platelet volume decreased 40.47 19.49 15 54305 105 2303660
Infection susceptibility increased 40.46 19.49 19 54301 255 2303510
Urinary incontinence 40.25 19.49 58 54262 4175 2299590
Antithrombin III decreased 40.11 19.49 13 54307 57 2303708
Breast neoplasm 40.11 19.49 18 54302 216 2303549
Alanine aminotransferase abnormal 40.11 19.49 18 54302 216 2303549
Diffuse large B-cell lymphoma stage IV 40.06 19.49 12 54308 38 2303727
Chronic sinusitis 40.04 19.49 24 54296 541 2303224
Iris adhesions 40.03 19.49 14 54306 81 2303684
Fusarium infection 40.03 19.49 14 54306 81 2303684
Postoperative wound infection 40.00 19.49 32 54288 1164 2302601
Candida sepsis 40.00 19.49 16 54304 141 2303624
Otitis media 39.95 19.49 25 54295 610 2303155
Injection site erythema 39.92 19.49 185 54135 27702 2276063
Nephritis 39.90 19.49 22 54298 421 2303344
Pneumonia aspiration 39.64 19.49 54 54266 3688 2300077
Escherichia test positive 39.62 19.49 19 54301 268 2303497
Loeffler's syndrome 39.50 19.49 9 54311 4 2303761
Overdose 39.47 19.49 146 54174 19761 2284004
Gastroenteritis clostridial 39.46 19.49 14 54306 85 2303680
Paraparesis 39.43 19.49 21 54299 374 2303391
Cerebellar syndrome 39.42 19.49 24 54296 557 2303208
T-cell lymphoma 39.41 19.49 16 54304 147 2303618
Pulmonary sarcoidosis 39.35 19.49 17 54303 185 2303580
Aortic valve stenosis 39.35 19.49 20 54300 322 2303443
Therapy partial responder 39.33 19.49 21 54299 376 2303389
Ankle fracture 39.31 19.49 42 54278 2223 2301542
Adactyly 39.27 19.49 10 54310 13 2303752
Multiple fractures 39.24 19.49 25 54295 630 2303135
Balance disorder 39.19 19.49 92 54228 9655 2294110
Nodal osteoarthritis 39.19 19.49 14 54306 87 2303678
Raynaud's phenomenon 39.16 19.49 29 54291 939 2302826
Vitamin D decreased 38.97 19.49 30 54290 1031 2302734
Adjustment disorder with depressed mood 38.92 19.49 14 54306 89 2303676
Soft tissue swelling 38.90 19.49 13 54307 64 2303701
Pharyngeal ulceration 38.86 19.49 16 54304 153 2303612
Enterovirus test positive 38.84 19.49 10 54310 14 2303751
Cardiotoxicity 38.83 19.49 32 54288 1215 2302550
Respiratory tract haemorrhage 38.79 19.49 14 54306 90 2303675
Perirectal abscess 38.76 19.49 16 54304 154 2303611
Dry skin 38.66 19.49 73 54247 6579 2297186
Enterobacter bacteraemia 38.48 19.49 11 54309 28 2303737
Blood iron decreased 38.42 19.49 32 54288 1233 2302532
Lichen myxoedematosus 38.22 19.49 9 54311 6 2303759
Joint space narrowing 38.22 19.49 9 54311 6 2303759
Quadriparesis 38.00 19.49 19 54301 295 2303470
Joint contracture 37.96 19.49 17 54303 203 2303562
Varices oesophageal 37.90 19.49 21 54299 406 2303359
Full blood count abnormal 37.77 19.49 19 54301 299 2303466
Mitral valve disease 37.76 19.49 20 54300 352 2303413
Enterocolitis haemorrhagic 37.76 19.49 20 54300 352 2303413
Blood pressure abnormal 37.62 19.49 36 54284 1669 2302096
Peripheral sensory neuropathy 37.56 19.49 29 54291 1001 2302764
Lupus nephritis 37.54 19.49 19 54301 303 2303462
Menopausal symptoms 37.51 19.49 20 54300 357 2303408
Hemiplegia 37.50 19.49 33 54287 1372 2302393
Thyroid cancer 37.43 19.49 28 54292 921 2302844
Squamous cell carcinoma of lung 37.42 19.49 15 54305 133 2303632
Intraocular pressure increased 37.41 19.49 34 54286 1475 2302290
Magnetic resonance imaging brain abnormal 37.35 19.49 21 54299 418 2303347
Human rhinovirus test positive 37.31 19.49 10 54310 18 2303747
Abdominal tenderness 37.14 19.49 29 54291 1018 2302747
Emotional disorder 37.13 19.49 40 54280 2137 2301628
Serum amyloid A protein increased 37.10 19.49 9 54311 8 2303757
Pneumonia fungal 36.97 19.49 20 54300 368 2303397
Encopresis 36.97 19.49 10 54310 19 2303746
Spinal compression fracture 36.95 19.49 37 54283 1814 2301951
IIIrd nerve paralysis 36.93 19.49 15 54305 138 2303627
Scab 36.88 19.49 30 54290 1118 2302647
Altered state of consciousness 36.86 19.49 53 54267 3807 2299958
Anaphylactic shock 36.83 19.49 56 54264 4230 2299535
Ulcer haemorrhage 36.73 19.49 23 54297 562 2303203
Groin pain 36.61 19.49 32 54288 1318 2302447
Lung abscess 36.61 19.49 18 54302 269 2303496
Feeling hot 36.57 19.49 73 54247 6855 2296910
Skin haemorrhage 36.53 19.49 29 54291 1043 2302722
Intracranial pressure increased 36.47 19.49 28 54292 958 2302807
Sputum discoloured 36.47 19.49 30 54290 1136 2302629
Hydronephrosis 36.32 19.49 31 54289 1236 2302529
Skin hyperpigmentation 36.23 19.49 27 54293 883 2302882
Decubitus ulcer 36.19 19.49 32 54288 1339 2302426
Periodontitis 36.15 19.49 24 54296 650 2303115
Obstructive airways disorder 36.15 19.49 32 54288 1341 2302424
Subclavian vein thrombosis 36.14 19.49 17 54303 229 2303536
Subdural haematoma 36.11 19.49 40 54280 2206 2301559
Pelvic fracture 36.11 19.49 32 54288 1343 2302422
Injection site hypersensitivity 36.08 19.49 20 54300 387 2303378
Superinfection 35.97 19.49 18 54302 280 2303485
Renal cell carcinoma 35.95 19.49 25 54295 732 2303033
Endometrial adenocarcinoma 35.88 19.49 16 54304 189 2303576
Cholangiocarcinoma 35.84 19.49 15 54305 150 2303615
Skin plaque 35.82 19.49 31 54289 1260 2302505
Restless legs syndrome 35.74 19.49 40 54280 2231 2301534
Pruritus allergic 35.66 19.49 15 54305 152 2303613
Acute myeloid leukaemia recurrent 35.66 19.49 16 54304 192 2303573
Iridocyclitis 35.57 19.49 21 54299 460 2303305
Leukocytosis 35.48 19.49 50 54270 3526 2300239
Peripheral motor neuropathy 35.43 19.49 17 54303 240 2303525
Episcleritis 35.33 19.49 14 54306 120 2303645
Computerised tomogram thorax abnormal 35.32 19.49 15 54305 156 2303609
Stenotrophomonas infection 35.32 19.49 15 54305 156 2303609
Effusion 35.31 19.49 17 54303 242 2303523
Nonspecific reaction 35.22 19.49 20 54300 406 2303359
Sinus disorder 35.20 19.49 43 54277 2635 2301130
Body temperature decreased 35.16 19.49 31 54289 1292 2302473
Klebsiella bacteraemia 35.13 19.49 14 54306 122 2303643
Overlap syndrome 35.12 19.49 12 54308 64 2303701
Cognitive disorder 35.00 19.49 62 54258 5319 2298446
Beta haemolytic streptococcal infection 35.00 19.49 17 54303 247 2303518
Anaemia megaloblastic 34.95 19.49 13 54307 92 2303673
Post procedural complication 34.95 19.49 45 54275 2909 2300856
Appetite disorder 34.94 19.49 23 54297 614 2303151
Hypoproteinaemia 34.91 19.49 19 54301 354 2303411
Vaginal cancer 34.81 19.49 12 54308 66 2303699
Therapeutic response shortened 34.72 19.49 22 54298 549 2303216
Proteinuria 34.64 19.49 44 54276 2806 2300959
Cutaneous leishmaniasis 34.40 19.49 9 54311 14 2303751
Intraductal proliferative breast lesion 34.21 19.49 19 54301 369 2303396
Tooth disorder 34.21 19.49 53 54267 4070 2299695
Hydrocephalus 34.19 19.49 26 54294 877 2302888
Abscess rupture 34.17 19.49 11 54309 47 2303718
Cerebral thrombosis 34.12 19.49 19 54301 371 2303394
Haemodynamic instability 34.11 19.49 29 54291 1150 2302615
Tongue neoplasm malignant stage unspecified 34.11 19.49 15 54305 171 2303594
Spinal operation 33.99 19.49 25 54295 801 2302964
Menopause 33.98 19.49 18 54302 317 2303448
Varicose ulceration 33.80 19.49 11 54309 49 2303716
Septic embolus 33.72 19.49 14 54306 137 2303628
Myeloid leukaemia 33.53 19.49 12 54308 75 2303690
Blood alkaline phosphatase increased 33.40 19.49 68 54252 6477 2297288
Purulent discharge 33.27 19.49 25 54295 828 2302937
Gallbladder disorder 33.26 19.49 43 54277 2791 2300974
Monocyte count increased 33.25 19.49 21 54299 521 2303244
Blood pressure diastolic abnormal 33.13 19.49 12 54308 78 2303687
Moraxella infection 33.11 19.49 11 54309 53 2303712
Intestinal adenocarcinoma 33.07 19.49 10 54310 33 2303732
Carotid intima-media thickness increased 33.04 19.49 8 54312 7 2303758
Areflexia 32.97 19.49 22 54298 601 2303164
Polymyalgia rheumatica 32.93 19.49 20 54300 462 2303303
Helicobacter gastritis 32.85 19.49 16 54304 234 2303531
Left ventricular dysfunction 32.84 19.49 29 54291 1211 2302554
Hyperaesthesia 32.78 19.49 29 54291 1214 2302551
Mass excision 32.77 19.49 11 54309 55 2303710
Genital ulceration 32.75 19.49 13 54307 112 2303653
Pneumatosis intestinalis 32.68 19.49 19 54301 404 2303361
Leishmaniasis 32.64 19.49 9 54311 19 2303746
Granulomatosis with polyangiitis 32.57 19.49 15 54305 192 2303573
Completed suicide 32.56 19.49 13 54307 21021 2282744
Gastrointestinal lymphoma 32.52 19.49 8 54312 8 2303757
Decreased immune responsiveness 32.50 19.49 23 54297 693 2303072
Vascular injury 32.44 19.49 14 54306 152 2303613
Lymphocytosis 32.43 19.49 19 54301 410 2303355
White matter lesion 32.36 19.49 15 54305 195 2303570
Paresis 32.33 19.49 20 54300 478 2303287
Intra-abdominal fluid collection 32.31 19.49 16 54304 243 2303522
Gastric haemorrhage 32.30 19.49 27 54293 1046 2302719
Lymphadenectomy 32.28 19.49 14 54306 154 2303611
Electrolyte imbalance 32.27 19.49 36 54284 2001 2301764
Middle insomnia 32.23 19.49 31 54289 1446 2302319
Oesophageal squamous cell carcinoma 32.20 19.49 10 54310 37 2303728
Haematoma 32.02 19.49 58 54262 5063 2298702
Autoimmune haemolytic anaemia 31.98 19.49 23 54297 711 2303054
Metapneumovirus infection 31.90 19.49 12 54308 88 2303677
Flatulence 31.87 19.49 54 54266 4471 2299294
Lymphocyte count decreased 31.86 19.49 46 54274 3317 2300448
Smear cervix abnormal 31.86 19.49 17 54303 304 2303461
Acidosis 31.80 19.49 32 54288 1578 2302187
Pneumonitis chemical 31.78 19.49 10 54310 39 2303726
Transverse sinus thrombosis 31.69 19.49 13 54307 123 2303642
Hepatitis B virus test positive 31.69 19.49 11 54309 62 2303703
Salivary gland cancer 31.69 19.49 11 54309 62 2303703
CSF protein increased 31.65 19.49 14 54306 162 2303603
Spinal fusion surgery 31.57 19.49 20 54300 499 2303266
Incorrect route of product administration 31.56 19.49 59 54261 5277 2298488
Tachyphylaxis 31.54 19.49 11 54309 63 2303702
Intussusception 31.51 19.49 13 54307 125 2303640
Mycobacterium marinum infection 31.45 19.49 9 54311 23 2303742
Anaplastic large-cell lymphoma 31.45 19.49 9 54311 23 2303742
Bone tuberculosis 31.39 19.49 10 54310 41 2303724
Small cell carcinoma 31.39 19.49 10 54310 41 2303724
Loss of employment 31.33 19.49 13 54307 127 2303638
Rosacea 31.32 19.49 20 54300 506 2303259
Tongue disorder 31.22 19.49 27 54293 1096 2302669
Bacterial test positive 31.21 19.49 21 54299 582 2303183
Duodenal ulcer perforation 31.18 19.49 17 54303 318 2303447
Recurrent cancer 31.13 19.49 17 54303 319 2303446
Inflammatory pain 31.11 19.49 11 54309 66 2303699
Meningitis tuberculous 31.00 19.49 12 54308 96 2303669
Humerus fracture 30.98 19.49 27 54293 1108 2302657
Seronegative arthritis 30.97 19.49 11 54309 67 2303698
Craniosynostosis 30.97 19.49 11 54309 67 2303698
Chronic graft versus host disease in liver 30.92 19.49 9 54311 25 2303740
Acute hepatic failure 30.87 19.49 40 54280 2602 2301163
Lung neoplasm 30.86 19.49 25 54295 926 2302839
Rectal cancer metastatic 30.83 19.49 10 54310 44 2303721
Nocardiosis 30.81 19.49 16 54304 270 2303495
Pneumonia klebsiella 30.81 19.49 16 54304 270 2303495
Disseminated large cell lymphoma 30.80 19.49 7 54313 3 2303762
Ankle operation 30.76 19.49 14 54306 174 2303591
Diffuse large B-cell lymphoma stage II 30.75 19.49 8 54312 12 2303753
Septic arthritis staphylococcal 30.70 19.49 11 54309 69 2303696
Cholangitis 30.50 19.49 24 54296 852 2302913
Cushing's syndrome 30.50 19.49 23 54297 766 2302999
Iritis 30.47 19.49 20 54300 531 2303234
Large intestine perforation 30.44 19.49 28 54292 1234 2302531
Viral haemorrhagic cystitis 30.44 19.49 11 54309 71 2303694
Cytomegalovirus test positive 30.42 19.49 18 54302 396 2303369
Infected seroma 30.36 19.49 8 54312 13 2303752
Mucosal erosion 30.34 19.49 15 54305 227 2303538
Diverticulum 30.33 19.49 30 54290 1449 2302316
Secondary adrenocortical insufficiency 30.30 19.49 13 54307 139 2303626
Stevens-Johnson syndrome 30.22 19.49 51 54269 4208 2299557
Lymphangitis 30.21 19.49 14 54306 182 2303583
C-reactive protein 30.16 19.49 9 54311 28 2303737
Ankle brachial index decreased 30.14 19.49 7 54313 4 2303761
Pulse waveform abnormal 30.14 19.49 7 54313 4 2303761
Urinary tract obstruction 30.09 19.49 16 54304 284 2303481
Neurogenic bladder 30.06 19.49 18 54302 405 2303360
Intervertebral disc disorder 30.04 19.49 21 54299 620 2303145
Peripheral T-cell lymphoma unspecified 29.93 19.49 11 54309 75 2303690
Haemorrhage intracranial 29.88 19.49 39 54281 2555 2301210
Cerebral ischaemia 29.87 19.49 27 54293 1163 2302602
Intestinal ischaemia 29.87 19.49 26 54294 1065 2302700
Potentiating drug interaction 29.72 19.49 21 54299 631 2303134
Chemotherapeutic drug level increased 29.64 19.49 8 54312 15 2303750
Large intestinal ulcer 29.51 19.49 19 54301 488 2303277
Bacteriuria 29.40 19.49 12 54308 112 2303653
Ligament laxity 29.30 19.49 8 54312 16 2303749
Knee deformity 29.27 19.49 13 54307 152 2303613
Intentional product misuse 29.24 19.49 81 54239 9408 2294357
Gastric ulcer haemorrhage 29.22 19.49 23 54297 817 2302948
Device related sepsis 29.18 19.49 18 54302 428 2303337
Genital herpes 29.12 19.49 16 54304 304 2303461
Metastases to central nervous system 29.06 19.49 35 54285 2113 2301652
Neck surgery 29.03 19.49 14 54306 200 2303565
Autoimmune thyroiditis 29.02 19.49 20 54300 577 2303188
Chromosomal deletion 28.98 19.49 8 54312 17 2303748
Gestational trophoblastic tumour 28.97 19.49 7 54313 6 2303759
Primary immunodeficiency syndrome 28.97 19.49 7 54313 6 2303759
Red cell distribution width increased 28.84 19.49 20 54300 583 2303182
Hepatitis C 28.79 19.49 29 54291 1432 2302333
Heart rate decreased 28.76 19.49 46 54274 3630 2300135
Movement disorder 28.74 19.49 40 54280 2788 2300977
Eosinophilia 28.69 19.49 41 54279 2929 2300836
Cerebral hypoperfusion 28.64 19.49 11 54309 86 2303679
Contraindicated product prescribed 28.64 19.49 11 54309 86 2303679
Metastases to meninges 28.61 19.49 17 54303 377 2303388
Listeriosis 28.37 19.49 14 54306 211 2303554
Infected skin ulcer 28.35 19.49 16 54304 321 2303444
Hyponatraemia 28.34 19.49 100 54220 13225 2290540
Legionella infection 28.31 19.49 11 54309 89 2303676
Groin abscess 28.26 19.49 13 54307 166 2303599
Scleroderma renal crisis 28.21 19.49 11 54309 90 2303675
Rash vesicular 28.17 19.49 21 54299 687 2303078
Jaw fracture 28.14 19.49 18 54302 457 2303308
Ovarian cyst 28.10 19.49 33 54287 1940 2301825
Metastases to breast 28.01 19.49 10 54310 62 2303703
Live birth 27.99 19.49 27 54293 1264 2302501
Diffuse large B-cell lymphoma stage III 27.98 19.49 7 54313 8 2303757
Gingival ulceration 27.91 19.49 13 54307 171 2303594
Cerebral disorder 27.90 19.49 20 54300 615 2303150
Pulmonary sepsis 27.90 19.49 14 54306 219 2303546
Metastatic neoplasm 27.83 19.49 21 54299 700 2303065
Alpha haemolytic streptococcal infection 27.83 19.49 12 54308 130 2303635
Rheumatoid factor increased 27.62 19.49 14 54306 224 2303541
Infected varicose vein 27.61 19.49 6 54314 1 2303764
Oropharyngeal discolouration 27.61 19.49 6 54314 1 2303764
Papule 27.58 19.49 23 54297 888 2302877
Dependence 27.56 19.49 17 54303 404 2303361
Muscle spasticity 27.54 19.49 30 54290 1623 2302142
Varicella zoster pneumonia 27.53 19.49 7 54313 9 2303756
Plantar fascial fibromatosis 27.53 19.49 7 54313 9 2303756
Intra-abdominal haemorrhage 27.52 19.49 18 54302 475 2303290
Acute hepatitis B 27.50 19.49 9 54311 41 2303724
Infective tenosynovitis 27.50 19.49 9 54311 41 2303724
Pancreatic necrosis 27.48 19.49 10 54310 66 2303699
Myopathy 27.46 19.49 29 54291 1514 2302251
Serum ferritin decreased 27.46 19.49 14 54306 227 2303538
Uterine leiomyoma 27.43 19.49 29 54291 1516 2302249
Osteonecrosis of jaw 27.41 19.49 71 54249 7925 2295840
Haemoptysis 27.41 19.49 44 54276 3483 2300282
Burkitt's lymphoma 27.32 19.49 9 54311 42 2303723
Q fever 27.28 19.49 8 54312 23 2303742
Spinal deformity 27.26 19.49 13 54307 181 2303584
Myositis 27.23 19.49 27 54293 1308 2302457
Shoulder operation 27.12 19.49 16 54304 350 2303415
Injury 27.06 19.49 59 54261 5895 2297870
Retinopathy 27.03 19.49 19 54301 566 2303199
Therapeutic product effect delayed 27.00 19.49 18 54302 491 2303274
Eyelid ptosis 26.97 19.49 25 54295 1113 2302652
Breakthrough pain 26.94 19.49 13 54307 186 2303579
Fracture 26.82 19.49 38 54282 2693 2301072
Erythropoiesis abnormal 26.82 19.49 9 54311 45 2303720
Respiratory syncytial virus infection 26.78 19.49 20 54300 656 2303109
Sensorimotor disorder 26.73 19.49 11 54309 105 2303660
Pseudomonal bacteraemia 26.73 19.49 11 54309 105 2303660
Leukodystrophy 26.71 19.49 7 54313 11 2303754
Injection site swelling 26.66 19.49 107 54213 15044 2288721
Hip surgery 26.56 19.49 18 54302 505 2303260
Pulmonary congestion 26.55 19.49 32 54288 1933 2301832
Stenosis 26.46 19.49 11 54309 108 2303657
Oesophageal stenosis 26.46 19.49 17 54303 435 2303330
Chest discomfort 26.42 19.49 104 54216 14491 2289274
Meningitis viral 26.40 19.49 14 54306 247 2303518
Glucose tolerance impaired 26.40 19.49 19 54301 588 2303177
Herpes zoster disseminated 26.38 19.49 12 54308 149 2303616
Immunoglobulins decreased 26.37 19.49 11 54309 109 2303656
Engraftment syndrome 26.34 19.49 9 54311 48 2303717
Infectious pleural effusion 26.34 19.49 13 54307 196 2303569
Subdural abscess 26.34 19.49 7 54313 12 2303753
Breast cyst excision 26.34 19.49 7 54313 12 2303753
Pneumonia streptococcal 26.28 19.49 13 54307 197 2303568
Blood creatinine decreased 26.28 19.49 18 54302 514 2303251
Skin warm 26.21 19.49 20 54300 678 2303087
Peritoneal tuberculosis 26.19 19.49 11 54309 111 2303654
Eye irritation 26.19 19.49 43 54277 3469 2300296
Auditory disorder 26.16 19.49 10 54310 77 2303688
Scedosporium infection 26.16 19.49 10 54310 77 2303688
Arthritis viral 26.11 19.49 6 54314 3 2303762
Overwork 26.11 19.49 6 54314 3 2303762
Alopecia totalis 26.05 19.49 10 54310 78 2303687
Blood folate decreased 26.02 19.49 11 54309 113 2303652
Haemorrhagic diathesis 25.97 19.49 18 54302 524 2303241
Eye operation 25.97 19.49 15 54305 315 2303450
Blood glucose increased 25.93 19.49 92 54228 12198 2291567
Skin laceration 25.87 19.49 37 54283 2645 2301120
Blood pressure diastolic decreased 25.84 19.49 24 54296 1071 2302694
Rheumatoid vasculitis 25.74 19.49 9 54311 52 2303713
Hypertransaminasaemia 25.71 19.49 19 54301 613 2303152
Induration 25.71 19.49 15 54305 321 2303444
Fasciitis 25.68 19.49 11 54309 117 2303648
Transitional cell carcinoma 25.60 19.49 11 54309 118 2303647
Diffuse alveolar damage 25.55 19.49 12 54308 161 2303604
Atrophy 25.55 19.49 15 54305 325 2303440
Post lumbar puncture syndrome 25.49 19.49 12 54308 162 2303603
Swollen tongue 25.49 19.49 54 54266 5289 2298476
Laryngitis 25.47 19.49 27 54293 1416 2302349
Abdominal abscess 25.42 19.49 20 54300 710 2303055
Malnutrition 25.41 19.49 30 54290 1773 2301992
Refractory anaemia with an excess of blasts 25.41 19.49 10 54310 84 2303681
Jugular vein thrombosis 25.40 19.49 16 54304 395 2303370
Uterine cancer 25.35 19.49 21 54299 803 2302962
Nephrotic syndrome 25.31 19.49 24 54296 1100 2302665
Blood potassium increased 25.27 19.49 33 54287 2163 2301602
Cardiac disorder 25.27 19.49 68 54252 7765 2296000
Diplopia 25.26 19.49 42 54278 3423 2300342
Guttate psoriasis 25.20 19.49 11 54309 123 2303642
Rales 25.14 19.49 24 54296 1109 2302656
Invasive lobular breast carcinoma 25.12 19.49 11 54309 124 2303641
Contraindication to vaccination 25.07 19.49 8 54312 33 2303732
Glioblastoma 25.05 19.49 13 54307 219 2303546
Pneumococcal infection 25.01 19.49 10 54310 88 2303677
Speech disorder 24.89 19.49 60 54260 6404 2297361
Infection in an immunocompromised host 24.89 19.49 11 54309 127 2303638
Toxoplasmosis 24.85 19.49 12 54308 172 2303593
Wrist fracture 24.84 19.49 29 54291 1694 2302071
Affect lability 24.83 19.49 32 54288 2070 2301695
Urinary retention 24.82 19.49 43 54277 3624 2300141
Tinea infection 24.81 19.49 11 54309 128 2303637
Graft versus host disease in liver 24.78 19.49 9 54311 59 2303706
Dental caries 24.66 19.49 30 54290 1830 2301935
Tonsil cancer 24.66 19.49 9 54311 60 2303705
Intentional dose omission 24.60 19.49 15 54305 349 2303416
Vitamin B12 deficiency 24.60 19.49 18 54302 572 2303193
Central nervous system vasculitis 24.54 19.49 13 54307 229 2303536
Tuberculous pleurisy 24.53 19.49 10 54310 93 2303672
Cutaneous tuberculosis 24.52 19.49 8 54312 36 2303729
Philadelphia chromosome positive 24.52 19.49 8 54312 36 2303729
Drug use disorder 24.49 19.49 15 54305 352 2303413
Shock haemorrhagic 24.43 19.49 25 54295 1258 2302507
Diverticulum intestinal 24.43 19.49 19 54301 663 2303102
Herpes ophthalmic 24.42 19.49 12 54308 179 2303586
Bacillus bacteraemia 24.39 19.49 6 54314 6 2303759
Oestrogen receptor positive breast cancer 24.34 19.49 8 54312 37 2303728
Infusion site reaction 24.29 19.49 13 54307 234 2303531
Blood count abnormal 24.27 19.49 33 54287 2249 2301516
Weight fluctuation 24.21 19.49 19 54301 672 2303093
Osteochondrosis 24.19 19.49 12 54308 183 2303582
Allergy to vaccine 24.16 19.49 7 54313 19 2303746
Hypergammaglobulinaemia 24.16 19.49 10 54310 97 2303668
Facial paresis 24.06 19.49 18 54302 592 2303173
Corneal disorder 24.04 19.49 15 54305 364 2303401
Cardiac failure acute 24.04 19.49 23 54297 1066 2302699
Granulocytopenia 23.95 19.49 25 54295 1288 2302477
Listeria sepsis 23.93 19.49 9 54311 66 2303699
Epidermodysplasia verruciformis 23.90 19.49 7 54313 20 2303745
Granulomatous liver disease 23.89 19.49 10 54310 100 2303665
Joint instability 23.84 19.49 12 54308 189 2303576
Dysuria 23.84 19.49 44 54276 3897 2299868
Angioimmunoblastic T-cell lymphoma stage III 23.78 19.49 5 54315 0 2303765
Angioimmunoblastic T-cell lymphoma stage IV 23.78 19.49 5 54315 0 2303765
Thiopurine methyltransferase decreased 23.78 19.49 5 54315 0 2303765
Vulvovaginal candidiasis 23.76 19.49 15 54305 372 2303393
Hepatic infarction 23.72 19.49 10 54310 102 2303663
Pain of skin 23.64 19.49 26 54294 1422 2302343
White blood cell count abnormal 23.63 19.49 19 54301 696 2303069
Body mass index increased 23.53 19.49 11 54309 146 2303619
Sexually transmitted disease 23.52 19.49 8 54312 42 2303723
Eye inflammation 23.51 19.49 20 54300 794 2302971
Cardiogenic shock 23.49 19.49 34 54286 2457 2301308
Haematopoietic neoplasm 23.47 19.49 6 54314 8 2303757
Bladder disorder 23.47 19.49 23 54297 1098 2302667
Tendon disorder 23.46 19.49 20 54300 796 2302969
Periorbital oedema 23.42 19.49 22 54298 996 2302769
Meningoencephalitis viral 23.41 19.49 7 54313 22 2303743
Trichosporon infection 23.36 19.49 8 54312 43 2303722
Paradoxical drug reaction 23.35 19.49 16 54304 457 2303308
Pulmonary alveolar haemorrhage 23.31 19.49 19 54301 710 2303055
Cerebral haemorrhage 23.28 19.49 53 54267 5451 2298314
Necrotising retinitis 23.25 19.49 9 54311 72 2303693
Anal cancer 23.22 19.49 10 54310 108 2303657
Vasogenic cerebral oedema 23.14 19.49 9 54311 73 2303692
Diffuse alopecia 23.13 19.49 10 54310 109 2303656
Idiopathic pulmonary fibrosis 23.11 19.49 13 54307 259 2303506
Skin swelling 23.10 19.49 15 54305 391 2303374
Malignant melanoma in situ 23.08 19.49 12 54308 203 2303562
Ganglioneuroma 23.06 19.49 6 54314 9 2303756
Candida pneumonia 23.06 19.49 8 54312 45 2303720
Blastomycosis 23.06 19.49 8 54312 45 2303720
Mood swings 23.00 19.49 39 54281 3230 2300535
Glomerular filtration rate decreased 22.99 19.49 26 54294 1467 2302298
Anti-neutrophil cytoplasmic antibody positive vasculitis 22.95 19.49 14 54306 326 2303439
Lacrimation increased 22.95 19.49 36 54284 2794 2300971
Endodontic procedure 22.93 19.49 16 54304 471 2303294
Sneezing 22.92 19.49 33 54287 2373 2301392
Pallor 22.91 19.49 42 54278 3700 2300065
Device loosening 22.91 19.49 8 54312 46 2303719
Phlebitis 22.90 19.49 22 54298 1025 2302740
Brachiocephalic artery stenosis 22.87 19.49 5 54315 1 2303764
Respiratory tract ulceration 22.87 19.49 5 54315 1 2303764
Omental necrosis 22.87 19.49 5 54315 1 2303764
Sinusitis noninfective 22.87 19.49 5 54315 1 2303764
Pharyngeal abscess 22.83 19.49 9 54311 76 2303689
Cardiac arrest 22.81 19.49 101 54219 14829 2288936
Loss of proprioception 22.77 19.49 8 54312 47 2303718
Product dose omission 22.75 19.49 203 54117 38054 2265711
Cholecystectomy 22.75 19.49 27 54293 1605 2302160
Blast cells present 22.73 19.49 9 54311 77 2303688
Feeling cold 22.72 19.49 38 54282 3112 2300653
Bursitis infective staphylococcal 22.68 19.49 6 54314 10 2303755
Osteosarcoma 22.63 19.49 8 54312 48 2303717
Urine output decreased 22.62 19.49 26 54294 1493 2302272
Multi-organ disorder 22.59 19.49 13 54307 271 2303494
Cheilitis 22.57 19.49 20 54300 839 2302926
Postoperative wound complication 22.57 19.49 12 54308 213 2303552
Optic neuritis 22.56 19.49 27 54293 1619 2302146
Pneumonia pseudomonal 22.55 19.49 13 54307 272 2303493
Primary biliary cholangitis 22.52 19.49 12 54308 214 2303551
Blood immunoglobulin G decreased 22.52 19.49 12 54308 214 2303551
Blood fibrinogen decreased 22.51 19.49 11 54309 162 2303603
Colonic abscess 22.51 19.49 10 54310 117 2303648
Dermatitis exfoliative generalised 22.50 19.49 14 54306 338 2303427
Metatarsalgia 22.49 19.49 8 54312 49 2303716
Ankle arthroplasty 22.49 19.49 8 54312 49 2303716
Inappropriate antidiuretic hormone secretion 22.48 19.49 32 54288 2277 2301488
Metastases to skin 22.47 19.49 12 54308 215 2303550
Aphonia 22.39 19.49 24 54296 1275 2302490
Femoral neck fracture 22.39 19.49 24 54296 1275 2302490
Disseminated cryptococcosis 22.35 19.49 8 54312 50 2303715
Muscle atrophy 22.32 19.49 22 54298 1058 2302707
Adrenal atrophy 22.32 19.49 6 54314 11 2303754
T-cell type acute leukaemia 22.32 19.49 6 54314 11 2303754
American trypanosomiasis 22.31 19.49 7 54313 27 2303738
Epilepsy 22.26 19.49 47 54273 4592 2299173
Urinary tract infection bacterial 22.24 19.49 16 54304 495 2303270
Gastric cancer 22.21 19.49 18 54302 667 2303098
Status epilepticus 22.18 19.49 33 54287 2445 2301320
Polyp 22.14 19.49 18 54302 670 2303095
Multiple sclerosis relapse 22.12 19.49 4 54316 10939 2292826
Ureaplasma infection 22.11 19.49 7 54313 28 2303737
Dermatomyositis 22.09 19.49 15 54305 422 2303343
Tuberculosis of central nervous system 22.09 19.49 8 54312 52 2303713
Rash macular 22.09 19.49 40 54280 3491 2300274
Hyperpyrexia 22.08 19.49 17 54303 584 2303181
Sinusitis bacterial 22.05 19.49 9 54311 84 2303681
Thoracic vertebral fracture 22.03 19.49 17 54303 586 2303179
Tubular breast carcinoma 21.98 19.49 6 54314 12 2303753
Pyoderma gangrenosum 21.96 19.49 16 54304 505 2303260
Lumbar spinal stenosis 21.94 19.49 18 54302 679 2303086
Immune-mediated myositis 21.93 19.49 11 54309 172 2303593
Acinetobacter infection 21.93 19.49 11 54309 172 2303593
Lip and/or oral cavity cancer 21.92 19.49 10 54310 125 2303640
Ischaemic stroke 21.91 19.49 39 54281 3358 2300407
Premature menopause 21.89 19.49 12 54308 227 2303538
Megacolon 21.89 19.49 13 54307 288 2303477
Marrow hyperplasia 21.85 19.49 10 54310 126 2303639
Proctitis 21.85 19.49 13 54307 289 2303476
Incontinence 21.84 19.49 25 54295 1429 2302336
Ejection fraction decreased 21.84 19.49 35 54285 2766 2300999
Hepatic necrosis 21.81 19.49 22 54298 1088 2302677
Hypocalcaemia 21.81 19.49 42 54278 3841 2299924
Subarachnoid haemorrhage 21.78 19.49 30 54290 2070 2301695
Vasculitis necrotising 21.76 19.49 11 54309 175 2303590
Ecchymosis 21.75 19.49 26 54294 1557 2302208
Stress cardiomyopathy 21.75 19.49 25 54295 1436 2302329
Herpes zoster meningoencephalitis 21.73 19.49 7 54313 30 2303735
Synovectomy 21.71 19.49 8 54312 55 2303710
Rotator cuff repair 21.70 19.49 12 54308 231 2303534
Otitis media acute 21.64 19.49 10 54310 129 2303636
Upper respiratory tract inflammation 21.57 19.49 13 54307 296 2303469
Portal fibrosis 21.54 19.49 7 54313 31 2303734
Substance-induced psychotic disorder 21.53 19.49 13 54307 297 2303468
Renal neoplasm 21.48 19.49 11 54309 180 2303585
Gastric ulcer perforation 21.47 19.49 12 54308 236 2303529
Mitral valve incompetence 21.46 19.49 33 54287 2517 2301248
Lymphadenitis 21.46 19.49 15 54305 443 2303322
Swollen joint count 21.44 19.49 5 54315 3 2303762
Cranial nerve paralysis 21.37 19.49 7 54313 32 2303733
Myelomalacia 21.35 19.49 6 54314 14 2303751
JC virus granule cell neuronopathy 21.35 19.49 6 54314 14 2303751
Anal prolapse 21.35 19.49 6 54314 14 2303751
Abdominal adhesions 21.34 19.49 16 54304 528 2303237
Oesophagitis 21.32 19.49 29 54291 1977 2301788
Carotid artery occlusion 21.28 19.49 15 54305 449 2303316
Gallbladder rupture 21.24 19.49 9 54311 93 2303672
Lymphoedema 21.24 19.49 22 54298 1123 2302642
Medial tibial stress syndrome 21.19 19.49 7 54313 33 2303732
Normochromic normocytic anaemia 21.17 19.49 18 54302 714 2303051
Nephropathy 21.17 19.49 19 54301 811 2302954
Injection site inflammation 21.17 19.49 19 54301 811 2302954
Rectocele 21.16 19.49 11 54309 186 2303579
Portal hypertension 21.16 19.49 16 54304 535 2303230
Joint lock 21.16 19.49 14 54306 377 2303388
Infected dermal cyst 20.89 19.49 8 54312 62 2303703
Cardiac murmur 20.87 19.49 26 54294 1625 2302140
Tendon graft 20.85 19.49 5 54315 4 2303761
Ureterocele 20.85 19.49 5 54315 4 2303761
Superinfection bacterial 20.83 19.49 9 54311 98 2303667
Allergic oedema 20.83 19.49 9 54311 98 2303667
Prosthesis user 20.79 19.49 6 54314 16 2303749
Ovulation pain 20.79 19.49 6 54314 16 2303749
Bacillus test positive 20.79 19.49 6 54314 16 2303749
Eyelid exfoliation 20.78 19.49 8 54312 63 2303702
Glioblastoma multiforme 20.75 19.49 11 54309 194 2303571
Papilloma viral infection 20.75 19.49 13 54307 318 2303447
Cytogenetic abnormality 20.73 19.49 10 54310 143 2303622
Bone marrow oedema 20.73 19.49 10 54310 143 2303622
Morganella infection 20.69 19.49 7 54313 36 2303729
Blood pressure systolic abnormal 20.67 19.49 9 54311 100 2303665
Congestive cardiomyopathy 20.62 19.49 20 54300 943 2302822
Streptococcal bacteraemia 20.61 19.49 10 54310 145 2303620
Oral discomfort 20.59 19.49 23 54297 1280 2302485
Upper gastrointestinal haemorrhage 20.57 19.49 29 54291 2045 2301720
Nerve block 20.56 19.49 8 54312 65 2303700
Cardiovascular disorder 20.56 19.49 31 54289 2324 2301441
Symblepharon 20.54 19.49 7 54313 37 2303728
Pneumonia lipoid 20.52 19.49 6 54314 17 2303748
Gastritis haemorrhagic 20.52 19.49 12 54308 258 2303507
Labelled drug-drug interaction medication error 20.52 19.49 23 54297 1285 2302480
Intestinal obstruction 20.50 19.49 44 54276 4349 2299416
Infectious mononucleosis 20.49 19.49 14 54306 398 2303367
Cerebral aspergillosis 20.46 19.49 8 54312 66 2303699
Inflammatory bowel disease 20.36 19.49 16 54304 567 2303198
Skull malformation 20.36 19.49 9 54311 104 2303661
Carcinoid tumour of the caecum 20.33 19.49 5 54315 5 2303760
Complicated appendicitis 20.33 19.49 5 54315 5 2303760
Drug specific antibody present 20.28 19.49 18 54302 757 2303008
Brain herniation 20.26 19.49 16 54304 571 2303194
Steatohepatitis 20.25 19.49 8 54312 68 2303697
Menorrhagia 20.25 19.49 39 54281 3567 2300198
Butterfly rash 20.21 19.49 11 54309 205 2303560
Infective aneurysm 20.15 19.49 8 54312 69 2303696
Thyroid cyst 20.13 19.49 9 54311 107 2303658
Encephalomyelitis 20.08 19.49 7 54313 40 2303725
Ligament sprain 20.06 19.49 24 54296 1439 2302326
Neurological decompensation 20.05 19.49 13 54307 338 2303427
Meningitis cryptococcal 20.02 19.49 11 54309 209 2303556
Haemochromatosis 19.98 19.49 9 54311 109 2303656
Reversible cerebral vasoconstriction syndrome 19.96 19.49 12 54308 272 2303493
Malignant peritoneal neoplasm 19.95 19.49 10 54310 156 2303609
Graft versus host disease in lung 19.94 19.49 7 54313 41 2303724
Chemotherapeutic drug level above therapeutic 19.85 19.49 5 54315 6 2303759
Ocular lymphoma 19.85 19.49 5 54315 6 2303759
Lung squamous cell carcinoma stage I 19.85 19.49 5 54315 6 2303759
Lymphadenopathy mediastinal 19.85 19.49 13 54307 344 2303421
Breast cancer metastatic 19.83 19.49 29 54291 2115 2301650
Sinus congestion 19.82 19.49 28 54292 1979 2301786
Scleral disorder 19.80 19.49 7 54313 42 2303723
Peptostreptococcus infection 19.80 19.49 6 54314 20 2303745
Rib fracture 19.75 19.49 32 54288 2553 2301212
Furuncle 19.75 19.49 20 54300 994 2302771
Compression fracture 19.74 19.49 19 54301 887 2302878
Mycotic allergy 19.66 19.49 7 54313 43 2303722
Chronic gastritis 19.61 19.49 12 54308 281 2303484
Cerebral haemangioma 19.57 19.49 6 54314 21 2303744
Lung hyperinflation 19.56 19.49 9 54311 115 2303650
Cryoglobulinaemia 19.56 19.49 9 54311 115 2303650
Metabolic disorder 19.54 19.49 16 54304 602 2303163
Corona virus infection 19.53 19.49 7 54313 44 2303721
Scar pain 19.53 19.49 7 54313 44 2303721
Neoplasm 19.49 19.49 21 54299 1122 2302643

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 9649.92 22.74 4046 20951 59755 1662029
Rheumatoid arthritis 2938.91 22.74 867 24130 3718 1718066
Drug intolerance 2290.94 22.74 766 24231 5296 1716488
Febrile neutropenia 2180.54 22.74 865 24132 10235 1711549
Pancytopenia 1859.49 22.74 777 24220 10580 1711204
Mucosal inflammation 1637.76 22.74 543 24454 3626 1718158
Treatment failure 1553.73 22.74 529 24468 3872 1717912
Neutropenia 1480.67 22.74 768 24229 17492 1704292
Joint swelling 1460.98 22.74 556 24441 5797 1715987
Drug hypersensitivity 1456.49 22.74 715 24282 14420 1707364
Pyrexia 1412.83 22.74 1043 23954 45357 1676427
Therapeutic product effect incomplete 1384.13 22.74 513 24484 4935 1716849
Pneumonia 1311.52 22.74 996 24001 45186 1676598
Stomatitis 1242.18 22.74 473 24524 4931 1716853
Off label use 1219.66 22.74 888 24109 37683 1684101
Nausea 1193.06 22.74 983 24014 50213 1671571
Product use in unapproved indication 1140.82 22.74 522 24475 8900 1712884
Arthralgia 1135.05 22.74 704 24293 22740 1699044
Synovitis 1001.25 22.74 253 24744 492 1721292
Pain 989.85 22.74 678 24319 25979 1695805
Sepsis 968.71 22.74 595 24402 18843 1702941
Contraindicated product administered 966.02 22.74 283 24714 1161 1720623
Bone marrow failure 893.25 22.74 369 24628 4831 1716953
Febrile bone marrow aplasia 888.60 22.74 238 24759 640 1721144
Condition aggravated 880.68 22.74 578 24419 20572 1701212
Therapeutic product effect decreased 838.06 22.74 373 24624 5924 1715860
Thrombocytopenia 779.61 22.74 537 24460 20712 1701072
Posterior reversible encephalopathy syndrome 770.77 22.74 239 24758 1236 1720548
Toxicity to various agents 739.97 22.74 590 24407 28551 1693233
Infection 731.15 22.74 423 24574 11937 1709847
Pain in extremity 722.92 22.74 486 24511 17986 1703798
Acute kidney injury 718.39 22.74 626 24371 34318 1687466
Liver function test increased 715.14 22.74 228 24769 1311 1720473
Musculoskeletal stiffness 692.90 22.74 320 24677 5556 1716228
Septic shock 692.30 22.74 354 24643 7755 1714029
Leukoencephalopathy 661.41 22.74 185 24812 615 1721169
Pneumocystis jirovecii pneumonia 643.86 22.74 237 24760 2219 1719565
Leukopenia 612.28 22.74 331 24666 8149 1713635
Renal failure 585.12 22.74 441 24556 19576 1702208
Headache 554.30 22.74 538 24459 33838 1687946
Hypofibrinogenaemia 554.02 22.74 124 24873 94 1721690
Vomiting 553.96 22.74 565 24432 37750 1684034
Alanine aminotransferase increased 520.78 22.74 340 24657 11938 1709846
Venoocclusive liver disease 520.43 22.74 159 24838 774 1721010
Hepatic enzyme increased 510.26 22.74 270 24727 6351 1715433
Multiple organ dysfunction syndrome 508.40 22.74 302 24695 8940 1712844
Epstein-Barr virus infection 503.39 22.74 162 24835 963 1720821
Drug clearance decreased 498.03 22.74 115 24882 117 1721667
Drug interaction 496.88 22.74 462 24535 27496 1694288
Psoriasis 493.19 22.74 322 24675 11303 1710481
Gastrointestinal disorder 490.08 22.74 236 24761 4512 1717272
Pulmonary fibrosis 475.07 22.74 191 24806 2313 1719471
Neurotoxicity 474.49 22.74 180 24817 1844 1719940
Interstitial lung disease 472.03 22.74 293 24704 9403 1712381
Graft versus host disease 463.53 22.74 165 24832 1388 1720396
Diarrhoea 460.90 22.74 606 24391 53246 1668538
Respiratory failure 460.31 22.74 336 24661 14169 1707615
Anaemia 459.44 22.74 453 24544 29004 1692780
Haemophagocytic lymphohistiocytosis 454.31 22.74 160 24837 1300 1720484
Hypertension 452.96 22.74 375 24622 19073 1702711
Peripheral swelling 450.18 22.74 265 24732 7706 1714078
Cytomegalovirus infection 446.61 22.74 198 24799 3103 1718681
Lymphoproliferative disorder 440.38 22.74 120 24877 351 1721433
Arthropathy 436.83 22.74 187 24810 2680 1719104
Fatigue 421.30 22.74 563 24434 50218 1671566
Hepatic function abnormal 417.44 22.74 242 24755 6832 1714952
Haematotoxicity 412.48 22.74 134 24863 824 1720960
Bone erosion 410.91 22.74 98 24899 129 1721655
Hyperbilirubinaemia 408.25 22.74 167 24830 2120 1719664
Abdominal pain 406.53 22.74 368 24629 21122 1700662
Acute graft versus host disease 391.35 22.74 125 24872 722 1721062
Loss of personal independence in daily activities 390.46 22.74 164 24833 2235 1719549
Hepatotoxicity 385.35 22.74 175 24822 2909 1718875
Mouth ulceration 378.85 22.74 147 24850 1608 1720176
Acute lymphocytic leukaemia recurrent 378.21 22.74 97 24900 205 1721579
C-reactive protein abnormal 370.09 22.74 93 24904 174 1721610
Mobility decreased 364.57 22.74 183 24814 3837 1717947
Hypertriglyceridaemia 362.84 22.74 129 24868 1080 1720704
Diffuse large B-cell lymphoma 359.94 22.74 126 24871 1003 1720781
Hypersensitivity 349.52 22.74 250 24747 10194 1711590
Basal cell carcinoma 348.94 22.74 153 24844 2330 1719454
Dyspnoea 342.57 22.74 517 24480 51542 1670242
Acute myeloid leukaemia 340.71 22.74 160 24837 2881 1718903
Abdominal discomfort 340.29 22.74 233 24764 8848 1712936
Rash 331.14 22.74 436 24561 38257 1683527
Lymphadenopathy 328.79 22.74 172 24825 3942 1717842
Lung disorder 328.39 22.74 185 24812 4934 1716850
C-reactive protein increased 327.80 22.74 194 24803 5691 1716093
Psoriatic arthropathy 327.16 22.74 143 24854 2160 1719624
Colitis 326.21 22.74 172 24825 4008 1717776
Chronic graft versus host disease 323.56 22.74 98 24899 460 1721324
Arthritis 322.85 22.74 168 24829 3807 1717977
Epistaxis 322.82 22.74 218 24779 8088 1713696
Acute graft versus host disease in skin 321.17 22.74 98 24899 474 1721310
Osteoarthritis 321.08 22.74 141 24856 2155 1719629
Cough 319.00 22.74 306 24691 18891 1702893
Pleural effusion 317.86 22.74 242 24755 10868 1710916
Hand deformity 317.80 22.74 81 24916 165 1721619
Myelopathy 317.59 22.74 87 24910 261 1721523
Myelodysplastic syndrome 313.80 22.74 155 24842 3134 1718650
Hepatic steatosis 311.37 22.74 143 24854 2441 1719343
White blood cell count decreased 306.73 22.74 254 24743 12895 1708889
Pneumonitis 305.23 22.74 161 24836 3754 1718030
Liver function test abnormal 303.93 22.74 183 24814 5543 1716241
Malaise 300.19 22.74 363 24634 29202 1692582
Drug eruption 297.43 22.74 144 24853 2782 1719002
Diverticulitis 293.79 22.74 133 24864 2192 1719592
Encephalopathy 288.54 22.74 162 24835 4290 1717494
Transaminases increased 288.23 22.74 155 24842 3762 1718022
Apparent death 287.75 22.74 78 24919 222 1721562
Urticaria 284.53 22.74 236 24761 12005 1709779
Seizure 272.07 22.74 289 24708 20152 1701632
Herpes zoster 271.11 22.74 157 24840 4416 1717368
Graft versus host disease in gastrointestinal tract 258.73 22.74 77 24920 336 1721448
Weight decreased 258.40 22.74 296 24701 22457 1699327
Hepatic cirrhosis 255.95 22.74 126 24871 2527 1719257
Graft versus host disease in skin 251.89 22.74 76 24921 351 1721433
Disease recurrence 250.20 22.74 123 24874 2459 1719325
Epstein-Barr virus associated lymphoproliferative disorder 245.09 22.74 71 24926 276 1721508
Therapeutic response decreased 244.36 22.74 157 24840 5343 1716441
Muscular weakness 243.13 22.74 200 24797 10049 1711735
Renal impairment 240.61 22.74 215 24782 12099 1709685
Asthenia 238.48 22.74 352 24645 34318 1687466
Pulmonary embolism 237.51 22.74 219 24778 12840 1708944
Disability 232.41 22.74 76 24921 478 1721306
Fungal infection 231.92 22.74 112 24885 2150 1719634
Skin lesion 225.34 22.74 120 24877 2852 1718932
Platelet count decreased 224.00 22.74 236 24761 16287 1705497
Liver disorder 223.85 22.74 150 24847 5486 1716298
Hepatocellular injury 221.43 22.74 122 24875 3109 1718675
Therapy non-responder 221.05 22.74 155 24842 6111 1715673
General physical health deterioration 219.39 22.74 210 24787 12908 1708876
Bacteraemia 210.79 22.74 99 24898 1781 1720003
Drug level increased 210.18 22.74 112 24885 2665 1719119
Red blood cell sedimentation rate increased 209.37 22.74 84 24913 1009 1720775
Nodule 207.78 22.74 79 24918 813 1720971
Rheumatoid nodule 206.61 22.74 53 24944 112 1721672
Arthritis bacterial 205.90 22.74 73 24924 605 1721179
Second primary malignancy 204.98 22.74 82 24915 977 1720807
Aspartate aminotransferase increased 204.56 22.74 185 24812 10571 1711213
Alopecia 204.41 22.74 122 24875 3631 1718153
Skin ulcer 204.16 22.74 110 24887 2678 1719106
Foot deformity 203.19 22.74 66 24931 405 1721379
Back pain 201.90 22.74 224 24773 16389 1705395
Angiocentric lymphoma 201.58 22.74 46 24951 42 1721742
Red blood cell sedimentation rate abnormal 200.53 22.74 47 24950 54 1721730
Pulmonary toxicity 197.93 22.74 75 24922 764 1721020
Respiratory distress 194.65 22.74 133 24864 5024 1716760
Cytomegalovirus chorioretinitis 193.93 22.74 61 24936 332 1721452
Tumour lysis syndrome 192.60 22.74 91 24906 1660 1720124
Acute respiratory distress syndrome 192.27 22.74 115 24882 3436 1718348
Lymphoma 192.27 22.74 96 24901 1986 1719798
Lymphopenia 191.46 22.74 95 24902 1938 1719846
Post transplant lymphoproliferative disorder 191.33 22.74 71 24926 679 1721105
Staphylococcal sepsis 189.99 22.74 81 24916 1146 1720638
Cytogenetic abnormality 188.48 22.74 53 24944 180 1721604
Swelling 188.16 22.74 147 24850 6849 1714935
Musculoskeletal pain 187.11 22.74 129 24868 4945 1716839
Squamous cell carcinoma 186.85 22.74 91 24906 1780 1720004
Hemiparesis 186.69 22.74 103 24894 2631 1719153
Bronchopulmonary aspergillosis 186.54 22.74 86 24911 1480 1720304
Blood bilirubin increased 183.49 22.74 138 24859 6072 1715712
Coagulopathy 182.32 22.74 102 24895 2679 1719105
Staphylococcal infection 181.46 22.74 123 24874 4584 1717200
Cystitis haemorrhagic 180.80 22.74 66 24931 600 1721184
Aplasia 180.49 22.74 60 24937 400 1721384
Tuberculosis 175.14 22.74 87 24910 1779 1720005
Immunosuppression 174.53 22.74 69 24928 795 1720989
Acute lymphocytic leukaemia 172.73 22.74 61 24936 499 1721285
Muscle spasms 171.86 22.74 174 24823 11447 1710337
Inflammation 169.51 22.74 105 24892 3345 1718439
Ascites 169.19 22.74 126 24871 5460 1716324
Joint range of motion decreased 168.54 22.74 66 24931 740 1721044
Hypoxia 168.42 22.74 129 24868 5834 1715950
Cellulitis 165.53 22.74 132 24865 6336 1715448
Progressive multifocal leukoencephalopathy 164.52 22.74 80 24917 1559 1720225
Facial paralysis 164.20 22.74 84 24913 1832 1719952
Kaposi's sarcoma 163.88 22.74 66 24931 801 1720983
Neutropenic sepsis 162.43 22.74 77 24920 1415 1720369
Erythema 161.57 22.74 185 24812 14003 1707781
Pancreatitis 161.54 22.74 136 24861 7051 1714733
Aspergillus infection 159.16 22.74 74 24923 1299 1720485
Tachycardia 158.08 22.74 173 24824 12455 1709329
Aphasia 156.65 22.74 100 24897 3361 1718423
Product use issue 156.24 22.74 144 24853 8427 1713357
Osteonecrosis 156.21 22.74 105 24892 3857 1717927
Knee arthroplasty 156.16 22.74 65 24932 863 1720921
Device related infection 155.74 22.74 86 24911 2200 1719584
Decreased appetite 154.80 22.74 236 24761 23635 1698149
Impaired work ability 154.42 22.74 68 24929 1045 1720739
Cholestasis 153.85 22.74 101 24896 3564 1718220
Vein rupture 153.29 22.74 36 24961 42 1721742
Limb discomfort 153.13 22.74 73 24924 1359 1720425
Hypotension 151.34 22.74 263 24734 29391 1692393
Candida infection 151.06 22.74 80 24917 1878 1719906
Anti-cyclic citrullinated peptide antibody positive 149.74 22.74 33 24964 21 1721763
Nephrolithiasis 148.36 22.74 102 24895 3890 1717894
Deep vein thrombosis 147.51 22.74 149 24848 9771 1712013
Abscess 146.33 22.74 78 24919 1856 1719928
Diabetes mellitus 145.61 22.74 126 24871 6782 1715002
Mucormycosis 145.11 22.74 58 24939 689 1721095
Neuropathy peripheral 144.99 22.74 143 24854 9110 1712674
Joint stiffness 144.95 22.74 75 24922 1676 1720108
Paraesthesia 142.80 22.74 150 24847 10301 1711483
Cataract 141.62 22.74 89 24908 2909 1718875
Venoocclusive disease 141.16 22.74 47 24950 315 1721469
Chills 140.89 22.74 157 24840 11530 1710254
Acute graft versus host disease in intestine 140.66 22.74 45 24952 261 1721523
Neutrophil count decreased 140.64 22.74 117 24880 5964 1715820
Sleep disorder due to general medical condition, insomnia type 140.46 22.74 38 24959 107 1721677
Nasopharyngitis 139.14 22.74 145 24852 9865 1711919
Bacterial infection 139.11 22.74 75 24922 1827 1719957
Escherichia sepsis 138.72 22.74 54 24943 595 1721189
Adenovirus infection 137.57 22.74 49 24948 412 1721372
Lower respiratory tract infection 137.49 22.74 96 24901 3755 1718029
Prostate cancer 137.08 22.74 103 24894 4523 1717261
Hypogammaglobulinaemia 135.99 22.74 53 24944 586 1721198
Oxidative stress 135.76 22.74 27 24970 0 1721784
Crohn's disease 135.63 22.74 102 24895 4485 1717299
Blood creatinine increased 134.33 22.74 167 24830 13779 1708005
Cardiac failure 132.90 22.74 158 24839 12444 1709340
Mycobacterial infection 128.57 22.74 42 24955 263 1721521
Tenderness 127.43 22.74 58 24939 967 1720817
Synovial cyst 126.43 22.74 41 24956 250 1721534
Cytopenia 126.03 22.74 56 24941 880 1720904
Escherichia infection 126.02 22.74 57 24940 936 1720848
Osteomyelitis 125.97 22.74 75 24922 2220 1719564
Blood culture positive 125.70 22.74 53 24944 728 1721056
Dysphagia 124.97 22.74 138 24859 10030 1711754
Encephalitis 124.70 22.74 59 24938 1079 1720705
Rheumatoid factor positive 124.69 22.74 30 24967 42 1721742
Intentional product use issue 124.13 22.74 79 24918 2640 1719144
Mass 121.64 22.74 58 24939 1080 1720704
Drug-induced liver injury 120.97 22.74 83 24914 3154 1718630
Chemotherapeutic drug level increased 120.23 22.74 26 24971 13 1721771
Cytomegalovirus viraemia 120.16 22.74 47 24950 525 1721259
Hypoaesthesia 120.03 22.74 133 24864 9702 1712082
Sinusitis 119.75 22.74 100 24897 5123 1716661
Oropharyngeal pain 118.31 22.74 96 24901 4722 1717062
Bone cyst 117.25 22.74 29 24968 49 1721735
Hepatitis 115.95 22.74 96 24901 4859 1716925
Disease progression 115.13 22.74 173 24824 17090 1704694
Upper respiratory tract infection 114.35 22.74 88 24909 4005 1717779
Pulmonary mass 113.63 22.74 59 24938 1328 1720456
Bladder transitional cell carcinoma 113.05 22.74 41 24956 365 1721419
Inappropriate schedule of product administration 112.63 22.74 113 24884 7346 1714438
Hodgkin's disease 112.27 22.74 49 24948 736 1721048
Drug resistance 111.76 22.74 79 24918 3151 1718633
Histoplasmosis disseminated 111.35 22.74 36 24961 217 1721567
Chronic graft versus host disease in skin 111.27 22.74 30 24967 83 1721701
Influenza 110.51 22.74 107 24890 6660 1715124
Spermatozoa abnormal 109.39 22.74 27 24970 45 1721739
Disseminated intravascular coagulation 108.25 22.74 81 24916 3533 1718251
Hypoalbuminaemia 107.97 22.74 58 24939 1402 1720382
Burkitt's lymphoma 107.29 22.74 31 24966 119 1721665
Grip strength decreased 107.26 22.74 39 24958 350 1721434
Onychoclasis 106.59 22.74 34 24963 195 1721589
Nervous system disorder 106.34 22.74 69 24928 2385 1719399
Pleurisy 106 22.74 49 24948 848 1720936
Hepatomegaly 105.55 22.74 60 24937 1625 1720159
Leukaemia recurrent 105.45 22.74 36 24961 263 1721521
Respiratory tract infection 105.34 22.74 69 24928 2424 1719360
Hepatic failure 105.26 22.74 98 24899 5805 1715979
Paraplegia 104.91 22.74 42 24955 501 1721283
Urinary tract infection 104.89 22.74 126 24871 10027 1711757
Mental status changes 104.77 22.74 99 24898 5976 1715808
Bronchitis 104.31 22.74 94 24903 5338 1716446
Pulmonary tuberculosis 103.88 22.74 51 24946 1015 1720769
Neutropenic colitis 103.32 22.74 35 24962 249 1721535
Insomnia 102.72 22.74 159 24838 16117 1705667
Malignant melanoma 102.55 22.74 58 24939 1555 1720229
Emphysema 101.86 22.74 53 24944 1198 1720586
Skin mass 101.06 22.74 42 24955 555 1721229
Gait disturbance 100.63 22.74 138 24859 12532 1709252
Agranulocytosis 100.15 22.74 77 24920 3499 1718285
Demyelination 99.79 22.74 42 24955 574 1721210
Liver injury 99.39 22.74 60 24937 1822 1719962
Blood pressure increased 99.10 22.74 126 24871 10627 1711157
Sarcoidosis 98.67 22.74 40 24957 494 1721290
Cutaneous leishmaniasis 98.32 22.74 23 24974 26 1721758
Generalised tonic-clonic seizure 98.03 22.74 80 24917 3966 1717818
Splenomegaly 97.77 22.74 62 24935 2058 1719726
Clostridium difficile infection 97.21 22.74 58 24939 1723 1720061
Oesophagitis 97.05 22.74 57 24940 1644 1720140
Inflammatory marker increased 96.92 22.74 36 24961 345 1721439
Ill-defined disorder 96.84 22.74 59 24938 1822 1719962
Oral candidiasis 96.79 22.74 52 24945 1257 1720527
Bursitis 96.64 22.74 42 24955 624 1721160
Sensitivity to weather change 96.25 22.74 29 24968 133 1721651
Gamma-glutamyltransferase increased 95.49 22.74 87 24910 5011 1716773
Polyneuropathy 95.39 22.74 57 24940 1698 1720086
Non-Hodgkin's lymphoma 94.45 22.74 46 24951 899 1720885
Pericarditis 94.28 22.74 54 24943 1484 1720300
Haematochezia 94.01 22.74 85 24912 4847 1716937
Osteoporosis 93.72 22.74 54 24943 1501 1720283
Pneumocystis jirovecii infection 93.53 22.74 33 24964 269 1721515
Depression 93.06 22.74 154 24843 16515 1705269
Mucocutaneous ulceration 92.48 22.74 20 24977 10 1721774
Epstein Barr virus positive mucocutaneous ulcer 92.19 22.74 22 24975 29 1721755
Visceral leishmaniasis 92.18 22.74 27 24970 110 1721674
Clostridium difficile colitis 92.17 22.74 54 24943 1550 1720234
Juvenile idiopathic arthritis 92.08 22.74 30 24967 186 1721598
Gastric disorder 91.83 22.74 57 24940 1821 1719963
Fear of injection 91.70 22.74 31 24966 219 1721565
Joint effusion 91.31 22.74 39 24958 554 1721230
Dysarthria 91.25 22.74 86 24911 5173 1716611
Neck pain 91.04 22.74 71 24926 3295 1718489
Hypophagia 90.78 22.74 72 24925 3425 1718359
B-cell lymphoma 90.69 22.74 43 24954 790 1720994
Pericardial effusion 90.59 22.74 71 24926 3319 1718465
Facial paresis 90.48 22.74 36 24961 422 1721362
Hepatic enzyme abnormal 90.41 22.74 37 24960 469 1721315
Blood alkaline phosphatase increased 90.23 22.74 85 24912 5110 1716674
Immunodeficiency 89.79 22.74 38 24959 527 1721257
Folate deficiency 88.56 22.74 26 24971 107 1721677
Drug ineffective for unapproved indication 88.14 22.74 55 24942 1774 1720010
Bone marrow toxicity 88.05 22.74 33 24964 325 1721459
Photosensitivity reaction 87.82 22.74 54 24943 1696 1720088
Organising pneumonia 87.62 22.74 43 24954 855 1720929
Haemoglobin decreased 87.45 22.74 152 24845 16962 1704822
Confusional state 87.39 22.74 172 24825 21106 1700678
Pruritus 87.39 22.74 181 24816 23041 1698743
Acute promyelocytic leukaemia 87.06 22.74 27 24970 139 1721645
Productive cough 86.99 22.74 71 24926 3520 1718264
Toxic epidermal necrolysis 86.71 22.74 60 24937 2311 1719473
Arthritis infective 86.19 22.74 34 24963 389 1721395
Hepatic fibrosis 86.04 22.74 38 24959 588 1721196
Complications of bone marrow transplant 85.91 22.74 22 24975 46 1721738
Oral herpes 85.86 22.74 40 24957 705 1721079
Dyspnoea exertional 85.84 22.74 75 24922 4086 1717698
Intracranial pressure increased 85.46 22.74 40 24957 713 1721071
Herpes simplex 84.94 22.74 39 24958 664 1721120
Gastrointestinal toxicity 84.89 22.74 33 24964 362 1721422
Disseminated tuberculosis 84.75 22.74 36 24961 504 1721280
Viral haemorrhagic cystitis 84.69 22.74 23 24974 66 1721718
Renal cell carcinoma 84.63 22.74 50 24947 1458 1720326
Enterococcal infection 84.51 22.74 42 24955 859 1720925
Impaired healing 84.44 22.74 61 24936 2518 1719266
Human herpesvirus 8 infection 84.35 22.74 24 24973 86 1721698
Central nervous system lymphoma 84.18 22.74 27 24970 158 1721626
Lethargy 83.95 22.74 95 24902 7089 1714695
Staphylococcal bacteraemia 83.63 22.74 40 24957 750 1721034
Infusion related reaction 83.61 22.74 91 24906 6502 1715282
Drug specific antibody present 83.54 22.74 33 24964 379 1721405
Haematuria 83.33 22.74 97 24900 7463 1714321
Pseudomonas infection 83.20 22.74 47 24950 1257 1720527
Acne cystic 82.63 22.74 22 24975 57 1721727
Gait inability 82.53 22.74 67 24930 3296 1718488
Klebsiella infection 82.44 22.74 40 24957 775 1721009
Pulmonary mycosis 82.25 22.74 27 24970 172 1721612
Cushingoid 81.76 22.74 32 24965 358 1721426
Weight increased 81.71 22.74 118 24879 11239 1710545
Epstein-Barr viraemia 81.32 22.74 24 24973 101 1721683
Hip arthroplasty 81.26 22.74 39 24958 737 1721047
Potentiating drug interaction 81.10 22.74 38 24959 679 1721105
Hypokalaemia 80.87 22.74 88 24909 6286 1715498
Acute graft versus host disease in liver 80.80 22.74 26 24971 154 1721630
Tooth loss 79.92 22.74 36 24961 585 1721199
Oedema peripheral 79.29 22.74 138 24859 15412 1706372
Pulmonary thrombosis 79.03 22.74 39 24958 785 1720999
Diverticular perforation 78.67 22.74 33 24964 447 1721337
Subcutaneous abscess 78.52 22.74 37 24960 670 1721114
Nephropathy toxic 78.25 22.74 50 24947 1682 1720102
Pneumonia cytomegaloviral 78.17 22.74 31 24966 360 1721424
Adverse reaction 77.97 22.74 36 24961 621 1721163
Ataxia 77.82 22.74 56 24941 2297 1719487
Tachypnoea 77.72 22.74 56 24941 2302 1719482
Blood pressure fluctuation 77.58 22.74 45 24952 1267 1720517
Osteopenia 77.51 22.74 34 24963 517 1721267
Lung infiltration 77.46 22.74 54 24943 2105 1719679
Amyloidosis 77.43 22.74 30 24967 326 1721458
Oral disorder 76.64 22.74 36 24961 647 1721137
Joint ankylosis 76.13 22.74 19 24978 34 1721750
Oesophageal stenosis 75.86 22.74 29 24968 303 1721481
Diffuse large B-cell lymphoma recurrent 75.72 22.74 23 24974 109 1721675
Ankylosing spondylitis 74.48 22.74 37 24960 756 1721028
Brain oedema 74.32 22.74 53 24944 2143 1719641
Accidental overdose 73.97 22.74 69 24928 4095 1717689
Vitamin D deficiency 73.95 22.74 32 24965 470 1721314
Histoplasmosis 73.54 22.74 28 24969 289 1721495
Stenotrophomonas infection 73.54 22.74 25 24972 180 1721604
Wrist deformity 73.47 22.74 19 24978 42 1721742
Epidermal necrosis 72.96 22.74 24 24973 154 1721630
Stem cell transplant 72.85 22.74 31 24966 436 1721348
Glioblastoma multiforme 72.74 22.74 26 24971 221 1721563
Skin exfoliation 72.69 22.74 71 24926 4464 1717320
Bicytopenia 72.53 22.74 26 24971 223 1721561
Contraindication to medical treatment 72.53 22.74 23 24974 129 1721655
Strongyloidiasis 71.94 22.74 30 24967 400 1721384
Bacterial sepsis 71.74 22.74 34 24963 624 1721160
Rectal haemorrhage 71.15 22.74 77 24920 5465 1716319
Spinal compression fracture 71.00 22.74 37 24960 839 1720945
Atelectasis 70.86 22.74 49 24948 1885 1719899
Glioma 70.65 22.74 20 24977 70 1721714
Molluscum contagiosum 70.47 22.74 21 24976 92 1721692
Hepatosplenomegaly 69.71 22.74 33 24964 604 1721180
Hepatitis B 69.65 22.74 43 24954 1360 1720424
Intestinal polyp 69.47 22.74 23 24974 151 1721633
Herpes simplex oesophagitis 69.40 22.74 16 24981 16 1721768
Pancreatitis acute 69.30 22.74 66 24931 4021 1717763
Mucosal ulceration 68.96 22.74 23 24974 155 1721629
BK virus infection 68.88 22.74 30 24967 448 1721336
Lung adenocarcinoma 68.82 22.74 34 24963 686 1721098
Pneumothorax 68.60 22.74 55 24942 2657 1719127
Skin toxicity 68.53 22.74 32 24965 567 1721217
Dizziness 68.20 22.74 210 24787 34151 1687633
Clinodactyly 66.56 22.74 17 24980 35 1721749
Craniosynostosis 66.51 22.74 20 24977 91 1721693
Acute monocytic leukaemia 66.23 22.74 17 24980 36 1721748
Escherichia bacteraemia 66.02 22.74 26 24971 296 1721488
Polyarthritis 65.75 22.74 30 24967 503 1721281
Rheumatoid lung 65.74 22.74 19 24978 73 1721711
Thrombotic microangiopathy 65.08 22.74 40 24957 1255 1720529
Necrosis 64.77 22.74 36 24961 932 1720852
Blood lactate dehydrogenase increased 63.56 22.74 60 24937 3615 1718169
Hepatitis E 63.53 22.74 24 24973 242 1721542
Immune reconstitution inflammatory syndrome 63.31 22.74 42 24955 1507 1720277
Graft versus host disease in liver 63.09 22.74 20 24977 112 1721672
Medication error 62.82 22.74 67 24930 4676 1717108
Neoplasm recurrence 62.80 22.74 27 24970 390 1721394
Intervertebral discitis 62.46 22.74 25 24972 298 1721486
Non-alcoholic steatohepatitis 62.36 22.74 20 24977 117 1721667
Venous injury 62.03 22.74 17 24980 51 1721733
Rheumatoid factor negative 61.89 22.74 13 24984 4 1721780
Abscess limb 61.70 22.74 27 24970 408 1721376
Dactylitis 61.68 22.74 16 24981 36 1721748
Enterocolitis 61.64 22.74 34 24963 867 1720917
Tuberculin test positive 61.53 22.74 26 24971 359 1721425
Areflexia 60.75 22.74 28 24969 481 1721303
Acute respiratory failure 60.65 22.74 53 24944 2887 1718897
Mucosal toxicity 60.40 22.74 15 24982 26 1721758
Fall 60.32 22.74 173 24824 27041 1694743
Alveolitis 60.24 22.74 25 24972 329 1721455
Meningitis 60.06 22.74 34 24963 913 1720871
Renal disorder 60.00 22.74 61 24936 4025 1717759
Epilepsy 59.78 22.74 60 24937 3899 1717885
Skin infection 59.62 22.74 34 24963 926 1720858
Viral infection 59.53 22.74 52 24945 2831 1718953
Bladder cancer 59.16 22.74 45 24952 2011 1719773
Diarrhoea haemorrhagic 59.13 22.74 35 24962 1024 1720760
Spondylitis 59.12 22.74 22 24975 212 1721572
Pharyngitis 59.07 22.74 36 24961 1112 1720672
Myelitis transverse 58.90 22.74 21 24976 177 1721607
Myalgia 58.80 22.74 122 24875 15536 1706248
Inappropriate antidiuretic hormone secretion 58.72 22.74 42 24955 1706 1720078
Pseudostroke 58.49 22.74 12 24985 2 1721782
Gastrointestinal haemorrhage 58.14 22.74 115 24882 14152 1707632
Cytology abnormal 58.02 22.74 14 24983 20 1721764
Peritonitis 57.76 22.74 50 24947 2689 1719095
Dermatitis 57.33 22.74 41 24956 1665 1720119
Arachnoiditis 57.32 22.74 17 24980 73 1721711
Varicella zoster virus infection 57.31 22.74 21 24976 193 1721591
Chronic kidney disease 57.21 22.74 61 24936 4256 1717528
Pneumatosis intestinalis 56.99 22.74 27 24970 495 1721289
Pneumonia legionella 56.82 22.74 24 24973 331 1721453
Gilbert's syndrome 56.77 22.74 17 24980 76 1721708
Deafness 56.50 22.74 43 24954 1923 1719861
Pneumonia klebsiella 56.37 22.74 24 24973 338 1721446
Blood albumin decreased 56.29 22.74 40 24957 1608 1720176
Aphthous ulcer 55.80 22.74 30 24967 726 1721058
Skin erosion 55.74 22.74 24 24973 348 1721436
Metabolic acidosis 55.69 22.74 67 24930 5335 1716449
Chest pain 55.66 22.74 138 24859 19776 1702008
Autoimmune lymphoproliferative syndrome 55.49 22.74 12 24985 6 1721778
Motor dysfunction 55.45 22.74 34 24963 1062 1720722
Petechiae 55.36 22.74 39 24958 1546 1720238
Thrombosis 55.33 22.74 79 24918 7442 1714342
Sacroiliitis 55.05 22.74 19 24978 144 1721640
Liver abscess 55.03 22.74 28 24969 603 1721181
Pseudomonal sepsis 54.95 22.74 24 24973 361 1721423
Visual impairment 54.34 22.74 71 24926 6147 1715637
Keratitis 54.34 22.74 23 24974 319 1721465
C-reactive protein decreased 54.27 22.74 16 24981 67 1721717
Hyponatraemia 54.06 22.74 86 24911 8914 1712870
JC virus infection 53.90 22.74 20 24977 191 1721593
Whipple's disease 53.78 22.74 15 24982 49 1721735
Drug use disorder 53.74 22.74 25 24972 439 1721345
Lung neoplasm 53.71 22.74 29 24968 708 1721076
Cytotoxic oedema 53.70 22.74 13 24984 19 1721765
Parainfluenzae virus infection 53.54 22.74 20 24977 195 1721589
Infectious pleural effusion 53.51 22.74 23 24974 332 1721452
Lung abscess 53.38 22.74 25 24972 446 1721338
Empyema 53.23 22.74 25 24972 449 1721335
Laboratory test abnormal 53.23 22.74 59 24938 4300 1717484
Subdural hygroma 53.17 22.74 16 24981 73 1721711
Musculoskeletal discomfort 52.84 22.74 32 24965 977 1720807
Streptococcal infection 52.82 22.74 28 24969 658 1721126
Malignant neoplasm progression 52.79 22.74 110 24887 14048 1707736
Hyperhidrosis 52.50 22.74 102 24895 12386 1709398
Atrial fibrillation 52.41 22.74 114 24883 14997 1706787
Intervertebral disc protrusion 52.31 22.74 37 24960 1476 1720308
Chondropathy 51.97 22.74 18 24979 138 1721646
Incorrect dose administered 51.84 22.74 76 24921 7333 1714451
Lymph node tuberculosis 51.74 22.74 18 24979 140 1721644
Hyperglycaemia 51.52 22.74 63 24934 5102 1716682
T-cell type acute leukaemia 51.48 22.74 13 24984 25 1721759
Poor venous access 51.25 22.74 21 24976 267 1721517
Vasculitis 50.98 22.74 37 24960 1538 1720246
Abdominal distension 50.84 22.74 70 24927 6374 1715410
Toxic encephalopathy 50.76 22.74 28 24969 714 1721070
Tenosynovitis 50.69 22.74 21 24976 275 1721509
Pneumonia cryptococcal 50.66 22.74 18 24979 150 1721634
Fluid overload 50.54 22.74 41 24956 2014 1719770
Leukocytosis 50.52 22.74 52 24945 3481 1718303
Oral mucosa erosion 50.43 22.74 19 24978 190 1721594
Pseudomonas test positive 50.41 22.74 17 24980 119 1721665
Pneumonia bacterial 50.32 22.74 33 24964 1161 1720623
Odynophagia 50.23 22.74 28 24969 729 1721055
Portal hypertension 50.01 22.74 27 24970 659 1721125
Systemic inflammatory response syndrome 49.97 22.74 29 24968 817 1720967
Cerebral thrombosis 49.92 22.74 20 24977 239 1721545
Jaundice 49.56 22.74 67 24930 5995 1715789
Cerebral venous thrombosis 49.55 22.74 18 24979 161 1721623
Quadriplegia 49.54 22.74 22 24975 345 1721439
Oral pain 49.51 22.74 35 24962 1395 1720389
Spinal instability 49.32 22.74 11 24986 8 1721776
Anaphylactic reaction 49.12 22.74 67 24930 6046 1715738
Pyopneumothorax 48.99 22.74 12 24985 19 1721765
Skin plaque 48.91 22.74 29 24968 851 1720933
Night sweats 48.91 22.74 42 24955 2234 1719550
Feeding disorder 48.85 22.74 29 24968 853 1720931
Joint contracture 48.59 22.74 18 24979 171 1721613
Necrotising fasciitis 48.59 22.74 26 24971 623 1721161
Salivary gland cancer 48.56 22.74 15 24982 76 1721708
Prerenal failure 48.48 22.74 20 24977 259 1721525
Ulcer 48.46 22.74 32 24965 1139 1720645
Joint arthroplasty 48.40 22.74 15 24982 77 1721707
Actinic keratosis 48.32 22.74 25 24972 558 1721226
Varicella 48.15 22.74 22 24975 370 1721414
Dehydration 47.90 22.74 121 24876 17537 1704247
Lung neoplasm malignant 47.66 22.74 48 24949 3131 1718653
Adverse drug reaction 47.59 22.74 58 24939 4680 1717104
Fungaemia 47.21 22.74 20 24977 278 1721506
Epstein-Barr virus associated lymphoma 47.17 22.74 15 24982 85 1721699
Human rhinovirus test positive 46.95 22.74 13 24984 41 1721743
Squamous cell carcinoma of skin 46.75 22.74 32 24965 1210 1720574
Glomerular filtration rate decreased 46.64 22.74 34 24963 1423 1720361
Necrotising colitis 46.62 22.74 19 24978 238 1721546
Neoplasm progression 46.56 22.74 48 24949 3219 1718565
Injection site swelling 46.52 22.74 48 24949 3223 1718561
Systemic candida 46.24 22.74 21 24976 348 1721436
Atlantoaxial instability 46.24 22.74 10 24987 5 1721779
Therapy partial responder 46.20 22.74 20 24977 294 1721490
Injection site haemorrhage 46.02 22.74 44 24953 2693 1719091
Spinal pain 45.80 22.74 25 24972 624 1721160
Nasal cavity cancer 45.66 22.74 12 24985 29 1721755
Feeling abnormal 45.47 22.74 90 24907 11076 1710708
Tonsillar ulcer 45.47 22.74 11 24986 16 1721768
West Nile viral infection 45.37 22.74 15 24982 98 1721686
Fibromyalgia 45.30 22.74 20 24977 309 1721475
Gastrooesophageal reflux disease 45.25 22.74 56 24941 4591 1717193
Localised infection 45.22 22.74 36 24961 1721 1720063
Pyelonephritis 45.17 22.74 26 24971 721 1721063
Ankle deformity 45.07 22.74 11 24986 17 1721767
Neoplasm malignant 45.03 22.74 54 24943 4285 1717499
Steatorrhoea 44.98 22.74 15 24982 101 1721683
T-cell lymphoma 44.93 22.74 18 24979 215 1721569
Brain abscess 44.89 22.74 22 24975 436 1721348
Leishmaniasis 44.77 22.74 13 24984 51 1721733
Rheumatoid factor increased 44.61 22.74 15 24982 104 1721680
Cutaneous T-cell lymphoma 44.56 22.74 20 24977 322 1721462
Migraine 44.36 22.74 40 24957 2271 1719513
Foetal exposure during pregnancy 44.16 22.74 65 24932 6294 1715490
Pulmonary haemorrhage 44.13 22.74 35 24962 1664 1720120
Fine motor skill dysfunction 44.12 22.74 15 24982 108 1721676
Chronic myeloid leukaemia 44.10 22.74 25 24972 673 1721111
Constipation 44.09 22.74 106 24891 14894 1706890
Pneumonia pseudomonal 44.08 22.74 21 24976 390 1721394
Restrictive pulmonary disease 43.96 22.74 16 24981 144 1721640
Intervertebral disc space narrowing 43.80 22.74 13 24984 56 1721728
Cheilitis 43.79 22.74 23 24974 530 1721254
Folliculitis 43.64 22.74 25 24972 687 1721097
Leukaemia 43.58 22.74 26 24971 772 1721012
Total lung capacity decreased 43.42 22.74 15 24982 114 1721670
Gliosis 43.08 22.74 13 24984 60 1721724
Injection site papule 43.07 22.74 14 24983 86 1721698
Chronic obstructive pulmonary disease 43.00 22.74 62 24935 5891 1715893
Hypercalcaemia 42.98 22.74 36 24961 1850 1719934
Product prescribing error 42.92 22.74 40 24957 2370 1719414
Diverticulum 42.87 22.74 28 24969 978 1720806
Dermatitis exfoliative generalised 42.85 22.74 20 24977 354 1721430
Finger deformity 42.82 22.74 17 24980 198 1721586
Overdose 42.78 22.74 112 24885 16589 1705195
Blister 42.58 22.74 51 24946 4041 1717743
Engraftment syndrome 42.54 22.74 14 24983 90 1721694
Mean cell volume increased 42.50 22.74 18 24979 250 1721534
Dermatitis bullous 42.47 22.74 30 24967 1194 1720590
Neck mass 42.44 22.74 17 24980 203 1721581
Exercise tolerance decreased 42.39 22.74 23 24974 567 1721217
Unresponsive to stimuli 42.23 22.74 54 24943 4575 1717209
Gallbladder oedema 42.17 22.74 12 24985 43 1721741
Acute myelomonocytic leukaemia 42.17 22.74 12 24985 43 1721741
Adenocarcinoma of colon 42.14 22.74 21 24976 432 1721352
Hepatitis B reactivation 42.05 22.74 20 24977 370 1721414
Radiculopathy 41.87 22.74 21 24976 438 1721346
Endocarditis bacterial 41.78 22.74 16 24981 168 1721616
Stress 41.67 22.74 41 24956 2600 1719184
Paresis 41.66 22.74 20 24977 378 1721406
Abdominal pain upper 41.62 22.74 86 24911 10915 1710869
Blood fibrinogen decreased 41.53 22.74 16 24981 171 1721613
Trichosporon infection 41.40 22.74 14 24983 99 1721685
Physical disability 41.01 22.74 15 24982 137 1721647
Monoparesis 40.95 22.74 18 24979 275 1721509
Alanine aminotransferase abnormal 40.67 22.74 17 24980 228 1721556
Hodgkin's disease nodular sclerosis stage III 40.67 22.74 9 24988 6 1721778
Malnutrition 40.64 22.74 32 24965 1505 1720279
Thyroid cancer 40.62 22.74 19 24978 338 1721446
Fallot's tetralogy 40.45 22.74 15 24982 143 1721641
Hypercholesterolaemia 40.43 22.74 29 24968 1183 1720601
Brain herniation 40.34 22.74 23 24974 626 1721158
Osteolysis 40.32 22.74 18 24979 286 1721498
Pyoderma gangrenosum 40.32 22.74 18 24979 286 1721498
Rebound effect 39.95 22.74 17 24980 239 1721545
Still's disease 39.83 22.74 12 24985 55 1721729
Blindness 39.70 22.74 41 24956 2755 1719029
Pulmonary oedema 39.64 22.74 63 24934 6523 1715261
Pneumomediastinum 39.60 22.74 18 24979 299 1721485
Chylothorax 39.58 22.74 14 24983 115 1721669
Haematopoietic stem cell mobilisation 39.55 22.74 9 24988 8 1721776
Immobile 39.44 22.74 19 24978 362 1721422
Bone sarcoma 39.42 22.74 11 24986 36 1721748
Uveitis 39.37 22.74 27 24970 1024 1720760
Mineral metabolism disorder 39.34 22.74 10 24987 20 1721764
Peripheral sensory neuropathy 39.24 22.74 25 24972 836 1720948
Acute myeloid leukaemia recurrent 39.08 22.74 17 24980 253 1721531
Infective aneurysm 39.05 22.74 13 24984 87 1721697
Juvenile melanoma benign 39.04 22.74 9 24988 9 1721775
Lung consolidation 38.95 22.74 22 24975 588 1721196
Mycobacterium tuberculosis complex test positive 38.90 22.74 18 24979 312 1721472
Nocardiosis 38.84 22.74 21 24976 514 1721270
Rash pustular 38.74 22.74 28 24969 1156 1720628
Shock 38.69 22.74 49 24948 4112 1717672
Neurological symptom 38.66 22.74 23 24974 679 1721105
Ileus 38.64 22.74 38 24959 2408 1719376
Urinary incontinence 38.63 22.74 40 24957 2696 1719088
Scleroderma 38.54 22.74 17 24980 262 1721522
Diffuse alveolar damage 38.49 22.74 17 24980 263 1721521
Oedema 38.47 22.74 64 24933 6884 1714900
Serum procollagen type III N-terminal propeptide increased 38.44 22.74 8 24989 2 1721782
Endocarditis 38.43 22.74 26 24971 964 1720820
Thrombocytosis 38.19 22.74 22 24975 611 1721173
Peripheral arterial occlusive disease 38.17 22.74 24 24973 784 1721000
Synovial disorder 38.10 22.74 10 24987 24 1721760
Dermatitis exfoliative 38.08 22.74 31 24966 1530 1720254
Tooth fracture 37.96 22.74 20 24977 464 1721320
Angioimmunoblastic T-cell lymphoma 37.91 22.74 11 24986 43 1721741
Cytokine release syndrome 37.87 22.74 21 24976 541 1721243
Hepatorenal syndrome 37.50 22.74 20 24977 476 1721308
Haemorrhage 37.37 22.74 77 24920 9752 1712032
Dialysis 37.33 22.74 37 24960 2367 1719417
Inflammatory myofibroblastic tumour 37.26 22.74 10 24987 27 1721757
Cerebral infarction 37.26 22.74 54 24943 5155 1716629
Musculoskeletal disorder 37.18 22.74 26 24971 1018 1720766
Tonsil cancer 37.07 22.74 14 24983 141 1721643
Altered state of consciousness 37.07 22.74 44 24953 3453 1718331
Mucosal infection 37.00 22.74 10 24987 28 1721756
Thymus enlargement 36.84 22.74 9 24988 14 1721770
Cardio-respiratory arrest 36.75 22.74 74 24923 9219 1712565
Respiratory alkalosis 36.73 22.74 16 24981 239 1721545
Malignant melanoma in situ 36.56 22.74 14 24983 147 1721637
Oxygen saturation decreased 36.54 22.74 56 24941 5619 1716165
Meningitis staphylococcal 36.49 22.74 10 24987 30 1721754
C-reactive protein 36.46 22.74 9 24988 15 1721769
Bladder neoplasm 36.31 22.74 17 24980 303 1721481
Central nervous system leukaemia 36.24 22.74 11 24986 52 1721732
Osteosarcoma 36.24 22.74 11 24986 52 1721732
Premature baby 36.23 22.74 40 24957 2902 1718882
Cerebral aspergillosis 36.22 22.74 14 24983 151 1721633
Meningitis haemophilus 35.76 22.74 8 24989 6 1721778
Burkitt's lymphoma recurrent 35.76 22.74 8 24989 6 1721778
Mucosal erosion 35.66 22.74 14 24983 158 1721626
Pneumoperitoneum 35.62 22.74 17 24980 317 1721467
Adult T-cell lymphoma/leukaemia 35.62 22.74 13 24984 118 1721666
Micrognathia 35.59 22.74 12 24985 84 1721700
Pharyngeal inflammation 35.59 22.74 12 24985 84 1721700
Limb deformity 35.59 22.74 12 24985 84 1721700
Guillain-Barre syndrome 35.50 22.74 24 24973 889 1720895
Asthma 35.31 22.74 51 24946 4853 1716931
Papilloedema 35.30 22.74 21 24976 620 1721164
Skin necrosis 35.27 22.74 23 24974 801 1720983
Myeloid leukaemia 35.22 22.74 12 24985 87 1721697
Brain injury 35.15 22.74 25 24972 1006 1720778
Intussusception 35.14 22.74 13 24984 123 1721661
Cerebral haemorrhage 34.99 22.74 58 24939 6219 1715565
Skin cancer 34.94 22.74 28 24969 1351 1720433
Joint destruction 34.87 22.74 12 24985 90 1721694
Pulmonary air leakage 34.77 22.74 9 24988 20 1721764
X-ray abnormal 34.76 22.74 12 24985 91 1721693
Granulomatous pneumonitis 34.70 22.74 8 24989 8 1721776
Morphoea 34.69 22.74 10 24987 38 1721746
Dislocation of vertebra 34.69 22.74 10 24987 38 1721746
Pallor 34.65 22.74 42 24955 3369 1718415
Erysipelas 34.45 22.74 22 24975 739 1721045
Metastases to lung 34.36 22.74 29 24968 1506 1720278
Squamous cell carcinoma of lung 34.34 22.74 16 24981 282 1721502
Viral vasculitis 34.22 22.74 8 24989 9 1721775
Intestinal atresia 34.22 22.74 8 24989 9 1721775
Gingivitis ulcerative 34.17 22.74 9 24988 22 1721762
Body temperature decreased 34.13 22.74 25 24972 1054 1720730
Intestinal pseudo-obstruction 34.09 22.74 14 24983 179 1721605
Transfusion reaction 33.90 22.74 13 24984 137 1721647
Joint injury 33.88 22.74 25 24972 1066 1720718
Left ventricular dysfunction 33.73 22.74 26 24971 1185 1720599
Renal tubular necrosis 33.62 22.74 33 24964 2086 1719698
Cerebellar syndrome 33.56 22.74 19 24978 510 1721274
Tremor 33.55 22.74 88 24909 13043 1708741
White blood cell count increased 33.53 22.74 62 24935 7250 1714534
Hemiplegia 33.46 22.74 27 24970 1316 1720468
Glomerulonephritis membranous 33.45 22.74 15 24982 241 1721543
Cryptococcosis 33.44 22.74 16 24981 300 1721484
Chest discomfort 33.42 22.74 62 24935 7269 1714515
Hepatosplenic candidiasis 33.35 22.74 9 24988 25 1721759
Sleep disorder 33.35 22.74 45 24952 4018 1717766
Chronic graft versus host disease in liver 33.34 22.74 10 24987 45 1721739
Musculoskeletal chest pain 33.33 22.74 27 24970 1323 1720461
Pneumonia viral 33.24 22.74 17 24980 370 1721414
Dyspepsia 33.24 22.74 50 24947 4935 1716849
Electrolyte imbalance 33.19 22.74 28 24969 1453 1720331
Central nervous system lesion 33.01 22.74 24 24973 1000 1720784
Neuroendocrine carcinoma of the skin 32.93 22.74 13 24984 149 1721635
Haematopoietic neoplasm 32.92 22.74 8 24989 12 1721772
Periorbital infection 32.92 22.74 8 24989 12 1721772
Ureaplasma infection 32.92 22.74 8 24989 12 1721772
Muscle abscess 32.87 22.74 12 24985 109 1721675
Cytomegalovirus colitis 32.83 22.74 16 24981 313 1721471
Rash erythematous 32.67 22.74 44 24953 3921 1717863
Haemoptysis 32.64 22.74 49 24948 4827 1716957
Hyperkeratosis 32.63 22.74 20 24977 624 1721160
Angiodysplasia 32.62 22.74 11 24986 77 1721707
Meningitis chemical 32.60 22.74 9 24988 28 1721756
Metastasis 32.51 22.74 22 24975 816 1720968
Hepatic necrosis 32.50 22.74 21 24976 720 1721064
Bronchiectasis 32.46 22.74 19 24978 544 1721240
Erythrodermic psoriasis 32.33 22.74 14 24983 206 1721578
Oesophageal candidiasis 32.30 22.74 19 24978 549 1721235
Gastroenteritis 32.22 22.74 32 24965 2052 1719732
Cholelithiasis 32.20 22.74 39 24958 3126 1718658
Pneumonia fungal 32.14 22.74 18 24979 473 1721311
Systemic mycosis 31.96 22.74 13 24984 162 1721622
Anal abscess 31.95 22.74 22 24975 840 1720944
Somnolence 31.94 22.74 101 24896 16638 1705146
Fracture 31.91 22.74 24 24973 1054 1720730
Clostridium test positive 31.86 22.74 15 24982 271 1721513
Panniculitis 31.82 22.74 13 24984 164 1721620
Acute lymphocytic leukaemia refractory 31.81 22.74 8 24989 15 1721769
Diplopia 31.74 22.74 35 24962 2535 1719249
Cutaneous tuberculosis 31.68 22.74 9 24988 32 1721752
Extradural abscess 31.67 22.74 13 24984 166 1721618
Small cell lung cancer 31.59 22.74 16 24981 341 1721443
Superior sagittal sinus thrombosis 31.57 22.74 11 24986 86 1721698
Peritoneal tuberculosis 31.57 22.74 11 24986 86 1721698
Foetal growth restriction 31.52 22.74 20 24977 664 1721120
Graft versus host disease in eye 31.47 22.74 9 24988 33 1721751
Cardiomyopathy 31.46 22.74 36 24961 2716 1719068
Angioimmunoblastic T-cell lymphoma stage IV 31.43 22.74 7 24990 5 1721779
Pulmonary veno-occlusive disease 31.24 22.74 11 24986 89 1721695
Haemodialysis 31.23 22.74 35 24962 2581 1719203
Type 2 diabetes mellitus 31.21 22.74 30 24967 1848 1719936
Otitis media 31.15 22.74 17 24980 424 1721360
Haemolytic uraemic syndrome 30.94 22.74 17 24980 430 1721354
Contusion 30.87 22.74 50 24947 5259 1716525
Graft versus host disease in lung 30.83 22.74 10 24987 61 1721723
Mouth haemorrhage 30.72 22.74 22 24975 895 1720889
Terminal state 30.70 22.74 21 24976 793 1720991
Herpes simplex encephalitis 30.69 22.74 10 24987 62 1721722
Drug dependence 30.64 22.74 39 24958 3288 1718496
Peripheral motor neuropathy 30.61 22.74 14 24983 236 1721548
Necrotising fasciitis streptococcal 30.54 22.74 8 24989 19 1721765
Cardiac aneurysm 30.52 22.74 12 24985 136 1721648
Lymphoedema 30.41 22.74 17 24980 445 1721339
Proctalgia 30.41 22.74 20 24977 707 1721077
Surgery 30.31 22.74 36 24961 2827 1718957
Aplastic anaemia 30.21 22.74 20 24977 715 1721069
Foetal methotrexate syndrome 30.17 22.74 6 24991 0 1721784
Decreased immune responsiveness 30.12 22.74 15 24982 308 1721476
Dry mouth 30.10 22.74 42 24955 3871 1717913
Rhinorrhoea 30.07 22.74 42 24955 3875 1717909
Scab 30.03 22.74 20 24977 722 1721062
Pleuropericarditis 30.03 22.74 10 24987 67 1721717
Escherichia test positive 29.98 22.74 12 24985 143 1721641
Rheumatic disorder 29.93 22.74 11 24986 102 1721682
Hypersensitivity vasculitis 29.91 22.74 24 24973 1160 1720624
Haemorrhagic pneumonia 29.88 22.74 7 24990 8 1721776
Actinomycotic pulmonary infection 29.88 22.74 7 24990 8 1721776
Demyelinating polyneuropathy 29.78 22.74 14 24983 252 1721532
Meningitis listeria 29.74 22.74 11 24986 104 1721680
Atypical fibroxanthoma 29.70 22.74 8 24989 22 1721762
Candida endophthalmitis 29.70 22.74 8 24989 22 1721762
Large intestine infection 29.68 22.74 12 24985 147 1721637
Neurological decompensation 29.58 22.74 16 24981 392 1721392
Enterobacter infection 29.48 22.74 14 24983 258 1721526
Urine output decreased 29.47 22.74 26 24971 1434 1720350
Osteosclerosis 29.47 22.74 11 24986 107 1721677
Pancreatic calcification 29.44 22.74 8 24989 23 1721761
Mucosal haemorrhage 29.44 22.74 13 24984 201 1721583
Diffuse large B-cell lymphoma stage III 29.43 22.74 7 24990 9 1721775
Hepatic lesion 29.42 22.74 17 24980 475 1721309
Pancreatic neoplasm 29.39 22.74 12 24985 151 1721633
Herpes virus infection 29.38 22.74 17 24980 476 1721308
Back disorder 29.33 22.74 22 24975 962 1720822
Nodular regenerative hyperplasia 29.25 22.74 12 24985 153 1721631
Angioimmunoblastic T-cell lymphoma stage III 29.24 22.74 6 24991 1 1721783
Hypersensitivity pneumonitis 29.06 22.74 15 24982 333 1721451
Skin graft failure 29.01 22.74 7 24990 10 1721774
Rheumatoid vasculitis 28.95 22.74 8 24989 25 1721759
Spinal cord abscess 28.91 22.74 9 24988 47 1721737
Wernicke's encephalopathy 28.85 22.74 11 24986 114 1721670
Malabsorption 28.72 22.74 16 24981 416 1721368
Pneumonia escherichia 28.72 22.74 10 24987 78 1721706
Rash pruritic 28.62 22.74 43 24954 4239 1717545
Mucosal atrophy 28.61 22.74 7 24990 11 1721773
Cardiac arrest 28.47 22.74 94 24903 15836 1705948
Movement disorder 28.36 22.74 27 24970 1643 1720141
Chronic myelomonocytic leukaemia 28.31 22.74 12 24985 167 1721617
Vascular access complication 28.30 22.74 9 24988 51 1721733
Encephalitis enteroviral 28.23 22.74 7 24990 12 1721772
Fusarium infection 28.19 22.74 11 24986 122 1721662
Enterocolitis infectious 28.18 22.74 12 24985 169 1721615
Bursitis infective 28.18 22.74 10 24987 83 1721701
Traumatic lung injury 28.18 22.74 14 24983 286 1721498
Gastrointestinal necrosis 28.17 22.74 18 24979 605 1721179
Hepatitis B virus test positive 28.15 22.74 9 24988 52 1721732
Speech disorder 28.05 22.74 44 24953 4504 1717280
Pneumonia adenoviral 28.04 22.74 8 24989 29 1721755
Delirium 27.99 22.74 53 24944 6309 1715475
Renal function test abnormal 27.98 22.74 16 24981 438 1721346
Meningitis tuberculous 27.97 22.74 10 24987 85 1721699
Axial spondyloarthritis 27.88 22.74 7 24990 13 1721771
Enterococcal sepsis 27.87 22.74 12 24985 174 1721610
Eye disorder 27.86 22.74 26 24971 1543 1720241
Congestive cardiomyopathy 27.76 22.74 23 24974 1164 1720620
Immune recovery uveitis 27.74 22.74 6 24991 3 1721781
Anal fistula 27.73 22.74 18 24979 622 1721162
Coma 27.73 22.74 57 24940 7205 1714579
Keratoacanthoma 27.71 22.74 11 24986 128 1721656
Cholecystitis 27.70 22.74 26 24971 1554 1720230
Skin fissures 27.67 22.74 19 24978 722 1721062
Apnoea 27.65 22.74 25 24972 1424 1720360
Oliguria 27.57 22.74 23 24974 1175 1720609
Drug tolerance 27.53 22.74 15 24982 373 1721411
Rash vesicular 27.53 22.74 16 24981 452 1721332
Axonal neuropathy 27.50 22.74 12 24985 180 1721604
Epstein-Barr virus test positive 27.49 22.74 11 24986 131 1721653
Duodenal perforation 27.44 22.74 12 24985 181 1721603
Hypokinesia 27.42 22.74 23 24974 1184 1720600
Abdominal pain lower 27.42 22.74 23 24974 1184 1720600
Obliterative bronchiolitis 27.40 22.74 13 24984 239 1721545
Cryptosporidiosis infection 27.37 22.74 10 24987 91 1721693
Epididymitis 27.31 22.74 15 24982 379 1721405
Acute hepatic failure 27.29 22.74 29 24968 2014 1719770
Adenoviral hepatitis 27.23 22.74 8 24989 33 1721751
Septic arthritis staphylococcal 27.19 22.74 9 24988 59 1721725
Intestinal perforation 27.16 22.74 26 24971 1593 1720191
Hyperfibrinogenaemia 27.11 22.74 6 24991 4 1721780
Soft tissue infection 27.02 22.74 13 24984 247 1721537
Post procedural complication 26.98 22.74 31 24966 2349 1719435
Bacterial test positive 26.94 22.74 16 24981 471 1721313
Aspiration bone marrow abnormal 26.91 22.74 7 24990 16 1721768
Clear cell renal cell carcinoma 26.90 22.74 11 24986 139 1721645
Abscess fungal 26.85 22.74 8 24989 35 1721749
Hypothyroidism 26.79 22.74 32 24965 2528 1719256
Myelofibrosis 26.75 22.74 15 24982 395 1721389
Spinal osteoarthritis 26.68 22.74 19 24978 766 1721018
Depressed level of consciousness 26.67 22.74 53 24944 6539 1715245
Encephalitis fungal 26.61 22.74 7 24990 17 1721767
Meningitis aseptic 26.61 22.74 16 24981 482 1721302
Mycobacterium avium complex infection 26.60 22.74 14 24983 324 1721460
Iris adhesions 26.57 22.74 9 24988 64 1721720
Herpes simplex test positive 26.57 22.74 9 24988 64 1721720
Lumbar vertebral fracture 26.52 22.74 14 24983 326 1721458
Encephalitis viral 26.36 22.74 12 24985 200 1721584
Circulatory collapse 26.35 22.74 37 24960 3430 1718354
Sweat gland tumour 26.33 22.74 9 24988 66 1721718
Optic nerve disorder 26.28 22.74 11 24986 148 1721636
Neuroendocrine tumour 26.28 22.74 11 24986 148 1721636
Oesophageal squamous cell carcinoma 26.21 22.74 9 24988 67 1721717
Tubulointerstitial nephritis 26.18 22.74 34 24963 2924 1718860
Chronic graft versus host disease in intestine 26.15 22.74 8 24989 39 1721745
Minimal residual disease 26.02 22.74 6 24991 6 1721778
Blood test abnormal 26.01 22.74 20 24977 908 1720876
Cytomegalovirus test positive 25.97 22.74 16 24981 504 1721280
Skin disorder 25.92 22.74 29 24968 2135 1719649
Haemolytic anaemia 25.89 22.74 27 24970 1835 1719949
Sensory loss 25.87 22.74 19 24978 804 1720980
Crystal nephropathy 25.87 22.74 9 24988 70 1721714
Disorientation 25.87 22.74 47 24950 5422 1716362
Metastases to meninges 25.63 22.74 13 24984 278 1721506
Leptotrichia infection 25.55 22.74 6 24991 7 1721777
Tropical infectious disease 25.55 22.74 6 24991 7 1721777
Sinusitis fungal 25.54 22.74 9 24988 73 1721711
Nail dystrophy 25.51 22.74 8 24989 43 1721741
Myositis 25.50 22.74 25 24972 1578 1720206
Dysaesthesia 25.48 22.74 15 24982 434 1721350
Hyperammonaemia 25.44 22.74 21 24976 1057 1720727
Neoplasm 25.41 22.74 19 24978 827 1720957
Cryptococcal fungaemia 25.30 22.74 7 24990 22 1721762
Tooth abscess 25.29 22.74 19 24978 833 1720951
Staphylococcus test positive 25.18 22.74 15 24982 444 1721340
Furuncle 25.16 22.74 17 24980 629 1721155
Chronic hepatitis 25.15 22.74 11 24986 166 1721618
Enterovesical fistula 25.09 22.74 11 24986 167 1721617
Memory impairment 25.09 22.74 52 24945 6611 1715173
Superior mesenteric artery syndrome 25.06 22.74 7 24990 23 1721761
Jaundice cholestatic 25.05 22.74 19 24978 845 1720939
Loss of consciousness 25.01 22.74 86 24911 14789 1706995
Melaena 24.93 22.74 45 24952 5165 1716619
Tuberculous pleurisy 24.92 22.74 10 24987 120 1721664
Multiple-drug resistance 24.85 22.74 13 24984 297 1721487
Genitalia external ambiguous 24.84 22.74 7 24990 24 1721760
Joint warmth 24.82 22.74 9 24988 80 1721704
Inflammatory bowel disease 24.73 22.74 15 24982 459 1721325
Anxiety 24.58 22.74 88 24909 15439 1706345
Myocardial infarction 24.53 22.74 130 24867 27044 1694740
Rash maculo-papular 24.48 22.74 37 24960 3666 1718118
Cutaneous vasculitis 24.47 22.74 12 24985 238 1721546
Pustular psoriasis 24.42 22.74 14 24983 385 1721399
Heart rate decreased 24.42 22.74 32 24965 2777 1719007
Eosinophilia 24.40 22.74 36 24961 3491 1718293
Incorrect drug administration rate 24.35 22.74 13 24984 310 1721474
Microalbuminuria 24.34 22.74 10 24987 128 1721656
Ependymoma malignant 24.31 22.74 6 24991 10 1721774
Subcutaneous emphysema 24.29 22.74 11 24986 181 1721603
Bone pain 24.25 22.74 35 24962 3327 1718457
Injection site reaction 24.25 22.74 35 24962 3327 1718457
Nephrotic syndrome 24.25 22.74 23 24974 1393 1720391
Heavy chain disease 24.23 22.74 5 24992 1 1721783
Visual field defect 24.16 22.74 21 24976 1135 1720649
Focal dyscognitive seizures 24.09 22.74 13 24984 317 1721467
Gingival bleeding 24.03 22.74 22 24975 1274 1720510
Extensor plantar response 24.02 22.74 11 24986 186 1721598
Delayed puberty 23.97 22.74 8 24989 54 1721730
Tooth disorder 23.96 22.74 23 24974 1414 1720370
Mucocutaneous leishmaniasis 23.95 22.74 6 24991 11 1721773
Cerebrosclerosis 23.95 22.74 6 24991 11 1721773
Myeloproliferative neoplasm 23.93 22.74 10 24987 134 1721650
Opportunistic infection 23.87 22.74 13 24984 323 1721461
Sinus tachycardia 23.82 22.74 30 24967 2502 1719282
Gastroenteritis Escherichia coli 23.80 22.74 7 24990 29 1721755
Malignant melanoma stage I 23.80 22.74 7 24990 29 1721755
CNS ventriculitis 23.72 22.74 8 24989 56 1721728
Partial seizures 23.69 22.74 17 24980 694 1721090
Oesophageal adenocarcinoma 23.67 22.74 10 24987 138 1721646
Septic embolus 23.65 22.74 11 24986 193 1721591
Recurrent cancer 23.64 22.74 12 24985 257 1721527
Apoptotic colonopathy 23.60 22.74 6 24991 12 1721772
Gastrointestinal wall thickening 23.60 22.74 10 24987 139 1721645
Toxic leukoencephalopathy 23.60 22.74 8 24989 57 1721727
Reticulocyte count increased 23.46 22.74 9 24988 95 1721689
Blood cholesterol abnormal 23.40 22.74 11 24986 198 1721586
Ejection fraction decreased 23.39 22.74 28 24969 2217 1719567
Temporal lobe epilepsy 23.36 22.74 8 24989 59 1721725
White blood cell disorder 23.35 22.74 12 24985 264 1721520
Skin injury 23.30 22.74 11 24986 200 1721584
Blood stem cell transplant failure 23.25 22.74 7 24990 32 1721752
Mycobacterium marinum infection 23.13 22.74 8 24989 61 1721723
Pseudomonal bacteraemia 23.13 22.74 9 24988 99 1721685
Serum ferritin increased 23.05 22.74 18 24979 836 1720948
Adrenal insufficiency 23.05 22.74 22 24975 1343 1720441
Pneumoconiosis 23.02 22.74 8 24989 62 1721722
Carpal tunnel syndrome 23.01 22.74 17 24980 726 1721058
Skin laceration 23.01 22.74 26 24971 1935 1719849
Cerebral venous sinus thrombosis 22.97 22.74 9 24988 101 1721683
Respiratory tract infection fungal 22.89 22.74 9 24988 102 1721682
Campylobacter infection 22.89 22.74 9 24988 102 1721682
Product dispensing error 22.88 22.74 24 24973 1642 1720142
Fungal test positive 22.81 22.74 9 24988 103 1721681
Squamous cell carcinoma of the tongue 22.80 22.74 8 24989 64 1721720
Conus medullaris syndrome 22.80 22.74 5 24992 3 1721781
Embolism 22.76 22.74 20 24977 1097 1720687
Anal haemorrhage 22.75 22.74 12 24985 279 1721505

Pharmacologic Action:

SourceCodeDescription
ATC L01BA01 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
ANTIMETABOLITES
Folic acid analogues
ATC L04AX03 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
IMMUNOSUPPRESSANTS
IMMUNOSUPPRESSANTS
Other immunosuppressants
MeSH PA D000019 Abortifacient Agents
MeSH PA D000020 Abortifacient Agents, Nonsteroidal
FDA EPC N0000175584 Folate Analog Metabolic Inhibitor
FDA MoA N0000000111 Folic Acid Metabolism Inhibitors
MeSH PA D000963 Antimetabolites
MeSH PA D000964 Antimetabolites, Antineoplastic
MeSH PA D000970 Antineoplastic Agents
MeSH PA D018501 Antirheumatic Agents
MeSH PA D003879 Dermatologic Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D005493 Folic Acid Antagonists
MeSH PA D007155 Immunologic Factors
MeSH PA D007166 Immunosuppressive Agents
MeSH PA D009676 Noxae
MeSH PA D019384 Nucleic Acid Synthesis Inhibitors
MeSH PA D012102 Reproductive Control Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Psoriasis indication 9014002 DOID:8893
Rheumatoid arthritis indication 69896004 DOID:7148
Acute lymphoid leukemia indication 91857003 DOID:9952
Non-Hodgkin's lymphoma indication 118601006
Burkitt's lymphoma indication 118617000
Mycosis fungoides indication 118618005
Malignant tumor of head and/or neck indication 255056009
Osteosarcoma of bone indication 307576001 DOID:3376
Malignant tumor of lung indication 363358000
Juvenile rheumatoid arthritis indication 410795001
Carcinoma of female breast indication 447782002
Gestational trophoblastic neoplasia indication 609519004 DOID:3590
Meningeal Leukemia indication
Polymyositis off-label use 31384009
Vasculitis off-label use 31996006 DOID:865
Psoriasis with arthropathy off-label use 33339001
Systemic lupus erythematosus off-label use 55464009 DOID:9074
Acute myeloid leukemia, disease off-label use 91861009
Acute promyelocytic leukemia, FAB M3 off-label use 110004001
Wegener's granulomatosis off-label use 195353004 DOID:12132
Malignant tumor of urinary bladder off-label use 399326009 DOID:11054
Systemic Dermatomyositis off-label use
Alcoholism contraindication 7200002
Peptic ulcer contraindication 13200003 DOID:750
Dehydration contraindication 34095006
Fibrosis of lung contraindication 51615001 DOID:3770
Acute nephropathy contraindication 58574008
Hepatic failure contraindication 59927004
Stomatitis contraindication 61170000 DOID:9637
Interstitial pneumonia contraindication 64667001
Ulcerative colitis contraindication 64766004 DOID:8577
Leukopenia contraindication 84828003 DOID:615
Kidney disease contraindication 90708001 DOID:557
Disease of liver contraindication 235856003 DOID:409
Anemia contraindication 271737000 DOID:2355
Pregnancy, function contraindication 289908002
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Bone marrow depression contraindication 307762000
Ascites contraindication 389026000
Gastric ulcer contraindication 397825006 DOID:10808
Breastfeeding (mother) contraindication 413712001
Disorder of immune function contraindication 414029004
Methotrexate Toxicity contraindication
Pleural Effusions contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.61 acidic
pKa2 5.15 acidic
pKa3 12.92 acidic
pKa4 5.73 Basic
pKa5 4.51 Basic
pKa6 1.39 Basic
pKa7 0.75 Basic
pKa8 0.08 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
10MG/0.20ML (10MG/0.20ML) RASUVO MEDEXUS N205776 July 10, 2014 RX SOLUTION SUBCUTANEOUS 8664231 June 1, 2029 SUBCUTANEOUS INJECTION OF METHOTREXATE
12.5MG/0.25ML (12.5MG/0.25ML) RASUVO MEDEXUS N205776 July 10, 2014 RX SOLUTION SUBCUTANEOUS 8664231 June 1, 2029 SUBCUTANEOUS INJECTION OF METHOTREXATE
15MG/0.30ML (15MG/0.30ML) RASUVO MEDEXUS N205776 July 10, 2014 RX SOLUTION SUBCUTANEOUS 8664231 June 1, 2029 SUBCUTANEOUS INJECTION OF METHOTREXATE
17.5MG/0.35ML (17.5MG/0.35ML) RASUVO MEDEXUS N205776 July 10, 2014 RX SOLUTION SUBCUTANEOUS 8664231 June 1, 2029 SUBCUTANEOUS INJECTION OF METHOTREXATE
20MG/0.4ML (20MG/0.4ML) RASUVO MEDEXUS N205776 July 10, 2014 RX SOLUTION SUBCUTANEOUS 8664231 June 1, 2029 SUBCUTANEOUS INJECTION OF METHOTREXATE
22.5MG/0.45ML (22.5MG/0.45ML) RASUVO MEDEXUS N205776 July 10, 2014 RX SOLUTION SUBCUTANEOUS 8664231 June 1, 2029 SUBCUTANEOUS INJECTION OF METHOTREXATE
25MG/0.5ML (25MG/0.5ML) RASUVO MEDEXUS N205776 July 10, 2014 RX SOLUTION SUBCUTANEOUS 8664231 June 1, 2029 SUBCUTANEOUS INJECTION OF METHOTREXATE
27.5MG/0.55ML (27.5MG/0.55ML) RASUVO MEDEXUS N205776 July 10, 2014 DISCN SOLUTION SUBCUTANEOUS 8664231 June 1, 2029 SUBCUTANEOUS INJECTION OF METHOTREXATE
30MG/0.6ML (30MG/0.6ML) RASUVO MEDEXUS N205776 July 10, 2014 RX SOLUTION SUBCUTANEOUS 8664231 June 1, 2029 SUBCUTANEOUS INJECTION OF METHOTREXATE
7.5MG/0.15ML (7.5MG/0.15ML) RASUVO MEDEXUS N205776 July 10, 2014 RX SOLUTION SUBCUTANEOUS 8664231 June 1, 2029 SUBCUTANEOUS INJECTION OF METHOTREXATE
10MG/0.4ML (10MG/0.4ML) OTREXUP ANTARES PHARMA INC N204824 Oct. 11, 2013 RX SOLUTION SUBCUTANEOUS 8480631 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
10MG/0.4ML (10MG/0.4ML) OTREXUP ANTARES PHARMA INC N204824 Oct. 11, 2013 RX SOLUTION SUBCUTANEOUS 8579865 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
10MG/0.4ML (10MG/0.4ML) OTREXUP ANTARES PHARMA INC N204824 Oct. 11, 2013 RX SOLUTION SUBCUTANEOUS 8945063 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
10MG/0.4ML (10MG/0.4ML) OTREXUP ANTARES PHARMA INC N204824 Oct. 11, 2013 RX SOLUTION SUBCUTANEOUS 9421333 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
12.5MG/0.4ML (12.5MG/0.4ML) OTREXUP ANTARES PHARMA INC N204824 March 24, 2016 RX SOLUTION SUBCUTANEOUS 8480631 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
12.5MG/0.4ML (12.5MG/0.4ML) OTREXUP ANTARES PHARMA INC N204824 March 24, 2016 RX SOLUTION SUBCUTANEOUS 8579865 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
12.5MG/0.4ML (12.5MG/0.4ML) OTREXUP ANTARES PHARMA INC N204824 March 24, 2016 RX SOLUTION SUBCUTANEOUS 8945063 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
12.5MG/0.4ML (12.5MG/0.4ML) OTREXUP ANTARES PHARMA INC N204824 March 24, 2016 RX SOLUTION SUBCUTANEOUS 9421333 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
15MG/0.4ML (15MG/0.4ML) OTREXUP ANTARES PHARMA INC N204824 Oct. 11, 2013 RX SOLUTION SUBCUTANEOUS 8480631 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
15MG/0.4ML (15MG/0.4ML) OTREXUP ANTARES PHARMA INC N204824 Oct. 11, 2013 RX SOLUTION SUBCUTANEOUS 8579865 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
15MG/0.4ML (15MG/0.4ML) OTREXUP ANTARES PHARMA INC N204824 Oct. 11, 2013 RX SOLUTION SUBCUTANEOUS 8945063 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
15MG/0.4ML (15MG/0.4ML) OTREXUP ANTARES PHARMA INC N204824 Oct. 11, 2013 RX SOLUTION SUBCUTANEOUS 9421333 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
17.5MG/0.4ML (17.5MG/0.4ML) OTREXUP ANTARES PHARMA INC N204824 March 24, 2016 RX SOLUTION SUBCUTANEOUS 8480631 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
17.5MG/0.4ML (17.5MG/0.4ML) OTREXUP ANTARES PHARMA INC N204824 March 24, 2016 RX SOLUTION SUBCUTANEOUS 8579865 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
17.5MG/0.4ML (17.5MG/0.4ML) OTREXUP ANTARES PHARMA INC N204824 March 24, 2016 RX SOLUTION SUBCUTANEOUS 8945063 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
17.5MG/0.4ML (17.5MG/0.4ML) OTREXUP ANTARES PHARMA INC N204824 March 24, 2016 RX SOLUTION SUBCUTANEOUS 9421333 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
20MG/0.4ML (20MG/0.4ML) OTREXUP ANTARES PHARMA INC N204824 Oct. 11, 2013 RX SOLUTION SUBCUTANEOUS 8480631 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
20MG/0.4ML (20MG/0.4ML) OTREXUP ANTARES PHARMA INC N204824 Oct. 11, 2013 RX SOLUTION SUBCUTANEOUS 8579865 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
20MG/0.4ML (20MG/0.4ML) OTREXUP ANTARES PHARMA INC N204824 Oct. 11, 2013 RX SOLUTION SUBCUTANEOUS 8945063 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
20MG/0.4ML (20MG/0.4ML) OTREXUP ANTARES PHARMA INC N204824 Oct. 11, 2013 RX SOLUTION SUBCUTANEOUS 9421333 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
22.5MG/0.4ML (22.5MG/0.4ML) OTREXUP ANTARES PHARMA INC N204824 March 24, 2016 RX SOLUTION SUBCUTANEOUS 8480631 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
22.5MG/0.4ML (22.5MG/0.4ML) OTREXUP ANTARES PHARMA INC N204824 March 24, 2016 RX SOLUTION SUBCUTANEOUS 8579865 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
22.5MG/0.4ML (22.5MG/0.4ML) OTREXUP ANTARES PHARMA INC N204824 March 24, 2016 RX SOLUTION SUBCUTANEOUS 8945063 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
22.5MG/0.4ML (22.5MG/0.4ML) OTREXUP ANTARES PHARMA INC N204824 March 24, 2016 RX SOLUTION SUBCUTANEOUS 9421333 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
25MG/0.4ML (25MG/0.4ML) OTREXUP ANTARES PHARMA INC N204824 Oct. 11, 2013 RX SOLUTION SUBCUTANEOUS 8480631 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
25MG/0.4ML (25MG/0.4ML) OTREXUP ANTARES PHARMA INC N204824 Oct. 11, 2013 RX SOLUTION SUBCUTANEOUS 8579865 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
25MG/0.4ML (25MG/0.4ML) OTREXUP ANTARES PHARMA INC N204824 Oct. 11, 2013 RX SOLUTION SUBCUTANEOUS 8945063 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
25MG/0.4ML (25MG/0.4ML) OTREXUP ANTARES PHARMA INC N204824 Oct. 11, 2013 RX SOLUTION SUBCUTANEOUS 9421333 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
7.5MG/0.4ML (7.5MG/0.4ML) OTREXUP ANTARES PHARMA INC N204824 Nov. 7, 2014 DISCN SOLUTION SUBCUTANEOUS 8480631 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
7.5MG/0.4ML (7.5MG/0.4ML) OTREXUP ANTARES PHARMA INC N204824 Nov. 7, 2014 DISCN SOLUTION SUBCUTANEOUS 8579865 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
7.5MG/0.4ML (7.5MG/0.4ML) OTREXUP ANTARES PHARMA INC N204824 Nov. 7, 2014 DISCN SOLUTION SUBCUTANEOUS 8945063 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
7.5MG/0.4ML (7.5MG/0.4ML) OTREXUP ANTARES PHARMA INC N204824 Nov. 7, 2014 DISCN SOLUTION SUBCUTANEOUS 9421333 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
EQ 2MG BASE/ML XATMEP SILVERGATE PHARMS N208400 April 25, 2017 RX SOLUTION ORAL 10231927 Jan. 2, 2033 A METHOD FOR TREATING ACUTE LYMPHOBLASTIC LEUKEMIA
EQ 2MG BASE/ML XATMEP SILVERGATE PHARMS N208400 April 25, 2017 RX SOLUTION ORAL 10231927 Jan. 2, 2033 TREATMENT OF JUVENILE RHEUMATOID ARTHRITIS

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
EQ 2MG BASE/ML XATMEP SILVERGATE PHARMS N208400 April 25, 2017 RX SOLUTION ORAL April 25, 2024 TREATMENT OF OLIGOARTICULAR JUVENILE IDIOPATHIC ARTHRITIS (PERSISTENT OLIGOARTHRITIS, PSORIATIC JUVENILE IDIOPATHIC ARTHRITIS, ENTHESITIS-RELATED ARTHRITIS, OR UNDIFFERENTIATED ARTHRITIS) & POLYARTICULAR JUVENILE IDIOPATHIC ARTHRITIS IN CHILDREN 0-16 YRS
EQ 2MG BASE/ML XATMEP SILVERGATE PHARMS N208400 April 25, 2017 RX SOLUTION ORAL April 25, 2024 TREATMENT OF PEDIATRIC PATIENTS WITH ACUTE LYMPHOBLASTIC LEUKEMIA AS A COMPONENT OF A COMBINATION CHEOMOTHERAPY MAINTENANCE REGIMEN

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Dihydrofolate reductase Enzyme INHIBITOR Ki 8.92 IUPHAR DRUG LABEL
Multidrug resistance-associated protein 4 Transporter WOMBAT-PK
Multidrug resistance-associated protein 5 Transporter WOMBAT-PK
ATP-binding cassette sub-family G member 2 Transporter WOMBAT-PK
Multidrug resistance-associated protein 1 Transporter WOMBAT-PK
Canalicular multispecific organic anion transporter 1 Transporter WOMBAT-PK
Multidrug resistance protein 1 Transporter WOMBAT-PK
Thymidylate synthase Enzyme Ki 6.22 CHEMBL
Folylpolyglutamate synthase, mitochondrial Enzyme IC50 5.49 CHEMBL
Folate transporter 1 Unclassified Ki 5.46 CHEMBL
Proton-coupled folate transporter Transporter IC50 6.92 CHEMBL
Folate receptor alpha Membrane receptor IC50 6.94 CHEMBL
Folate receptor beta Membrane receptor IC50 6.97 CHEMBL
Dihydrofolate reductase Enzyme IC50 9 CHEMBL
Dihydrofolate reductase Enzyme IC50 8.89 CHEMBL
Bifunctional dihydrofolate reductase-thymidylate synthase Enzyme IC50 8.85 CHEMBL
Bifunctional dihydrofolate reductase-thymidylate synthase Enzyme Ki 9.89 CHEMBL
Thymidylate synthase Enzyme IC50 5.74 CHEMBL
Dihydrofolate reductase Unclassified IC50 8.85 CHEMBL
Thymidylate synthase Enzyme IC50 4.40 CHEMBL
Dihydrofolate reductase Unclassified IC50 8.77 CHEMBL
Dihydrofolate reductase Enzyme Ki 10.14 CHEMBL
Dihydrofolate reductase Enzyme IC50 7.91 CHEMBL
Dihydrofolate reductase Unclassified Ki 10.68 CHEMBL
Thymidylate synthase Enzyme Ki 4.35 CHEMBL
Dihydrofolate reductase Enzyme Ki 5.41 CHEMBL
Dihydrofolate reductase Enzyme IC50 7.72 CHEMBL
Pteridine reductase 1 Enzyme Ki 7.41 CHEMBL

External reference:

IDSource
4019828 VUID
N0000147916 NUI
C0025677 UMLSCUI
D00142 KEGG_DRUG
3IG1E710ZN UNII
7413-34-5 SECONDARY_CAS_RN
68887009 SNOMEDCT_US
387381009 SNOMEDCT_US
4019828 VANDF
6851 RXNORM
d00060 MMSL
73119 MMSL
12261 MMSL
002644 NDDF
CHEMBL426 ChEMBL_ID
CHEMBL34259 ChEMBL_ID
DB00563 DRUGBANK_ID
MTX PDB_CHEM_ID
CHEBI:50681 CHEBI
926 INN_ID
D008727 MESH_DESCRIPTOR_UI
CHEMBL3244648 ChEMBL_ID
126941 PUBCHEM_CID
4815 IUPHAR_LIGAND_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Methotrexate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0054-4550 TABLET 2.50 mg ORAL ANDA 15 sections
Methotrexate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0054-8550 TABLET 2.50 mg ORAL ANDA 15 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 0143-9367 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 1 g INTRA-ARTERIAL ANDA 14 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 0143-9516 SOLUTION 25 mg INTRA-ARTERIAL ANDA 14 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 0143-9517 SOLUTION 25 mg INTRA-ARTERIAL ANDA 14 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 0143-9518 SOLUTION 25 mg INTRA-ARTERIAL ANDA 14 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 0143-9519 SOLUTION 25 mg INTRA-ARTERIAL ANDA 14 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 0143-9830 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 1 g INTRA-ARTERIAL ANDA 14 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 0378-0014 TABLET 2.50 mg ORAL ANDA 15 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 0555-0572 TABLET 2.50 mg ORAL ANDA 15 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 0703-3671 INJECTION, SOLUTION 25 mg INTRA-ARTERIAL ANDA 12 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 0703-3675 INJECTION, SOLUTION 25 mg INTRA-ARTERIAL ANDA 12 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 0703-3678 INJECTION, SOLUTION 25 mg INTRA-ARTERIAL ANDA 13 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 16729-277 INJECTION 25 mg INTRA-ARTERIAL ANDA 14 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 21695-111 TABLET 2.50 mg ORAL ANDA 13 sections
METHOTREXATE HUMAN PRESCRIPTION DRUG LABEL 1 42254-110 TABLET 2.50 mg ORAL NDA 14 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 42291-594 TABLET 2.50 mg ORAL ANDA 14 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 43063-439 TABLET 2.50 mg ORAL ANDA 15 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 47335-235 TABLET 2.50 mg ORAL ANDA 16 sections
METHOTREXATE HUMAN PRESCRIPTION DRUG LABEL 1 50090-0294 TABLET 2.50 mg ORAL NDA 16 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 50090-3418 TABLET 2.50 mg ORAL ANDA 16 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 51079-670 TABLET 2.50 mg ORAL ANDA 15 sections
Trexall HUMAN PRESCRIPTION DRUG LABEL 1 51285-366 TABLET, FILM COATED 5 mg ORAL ANDA 14 sections
Trexall HUMAN PRESCRIPTION DRUG LABEL 1 51285-367 TABLET, FILM COATED 7.50 mg ORAL ANDA 14 sections
Trexall HUMAN PRESCRIPTION DRUG LABEL 1 51285-368 TABLET, FILM COATED 10 mg ORAL ANDA 14 sections
Trexall HUMAN PRESCRIPTION DRUG LABEL 1 51285-369 TABLET, FILM COATED 15 mg ORAL ANDA 14 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 51407-121 TABLET 2.50 mg ORAL ANDA 15 sections
Xatmep HUMAN PRESCRIPTION DRUG LABEL 1 52652-2001 SOLUTION 2.50 mg ORAL NDA 19 sections
Otrexup HUMAN PRESCRIPTION DRUG LABEL 1 54436-010 INJECTION, SOLUTION 10 mg SUBCUTANEOUS NDA 19 sections
Otrexup HUMAN PRESCRIPTION DRUG LABEL 1 54436-012 INJECTION, SOLUTION 12.50 mg SUBCUTANEOUS NDA 19 sections