methotrexate ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
folic acid analogues 1751 59-05-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • methotrexate
  • methotrexate sodium
  • amethopterin
  • amethopterine
  • L-Amethopterin
  • ledertrexate
  • metatrexan
  • methoxtrexate
  • methylaminopterin
An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.
  • Molecular weight: 454.45
  • Formula: C20H22N8O5
  • CLOGP: -0.03
  • LIPINSKI: 1
  • HAC: 13
  • HDO: 5
  • TPSA: 210.54
  • ALOGS: -3.42
  • ROTB: 9

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
2.50 mg O
2.50 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.45 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 81 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 1.10 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 33 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.43 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 2.10 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.37 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 3.90 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Dec. 7, 1953 FDA DAVA PHARMS INC
March 26, 2019 PMDA PFIZER JAPAN INC.

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 13643.69 11.89 35857 774392 783476 49011399
Drug intolerance 4585.02 11.89 10532 799717 208572 49586303
Treatment failure 3346.71 11.89 7033 803216 130604 49664271
Joint swelling 2718.21 11.89 9364 800885 235922 49558953
Therapeutic product effect incomplete 2416.73 11.89 4841 805408 86674 49708201
Death 2209.67 11.89 1233 809016 324146 49470729
Arthralgia 2187.49 11.89 13219 797030 425483 49369392
Drug hypersensitivity 2013.58 11.89 8651 801598 242359 49552516
Therapeutic product effect decreased 1961.17 11.89 5692 804557 130358 49664517
Completed suicide 1935.87 11.89 35 810214 131854 49663021
Contraindicated product administered 1908.11 11.89 5978 804271 142980 49651895
Rheumatoid arthritis 1862.31 11.89 7283 802966 195267 49599608
Synovitis 1617.07 11.89 5005 805244 118860 49676015
Musculoskeletal stiffness 1290.77 11.89 4755 805494 123726 49671149
Liver function test increased 1263.79 11.89 1793 808456 23813 49771062
Lymphoproliferative disorder 988.96 11.89 601 809648 2276 49792599
Constipation 983.85 11.89 914 809335 184794 49610081
Arthropathy 935.42 11.89 4991 805258 152915 49641960
Hypotension 921.74 11.89 1467 808782 234002 49560873
Alopecia 887.13 11.89 6834 803415 238213 49556662
Acute kidney injury 869.02 11.89 1446 808803 226612 49568263
Dyspnoea 812.49 11.89 5290 804959 542318 49252557
Dehydration 764.79 11.89 787 809462 151662 49643213
Intentional overdose 731.97 11.89 75 810174 62429 49732446
Infection 721.94 11.89 4992 805257 167962 49626913
Pain 720.89 11.89 13131 797118 565772 49229103
Psoriatic arthropathy 706.59 11.89 1999 808250 45033 49749842
Drug abuse 705.53 11.89 70 810179 59776 49735099
Psoriasis 699.11 11.89 2562 807687 66438 49728437
Somnolence 697.04 11.89 874 809375 154111 49640764
Hyponatraemia 679.22 11.89 345 809904 95794 49699081
C-reactive protein abnormal 642.76 11.89 1394 808855 26415 49768460
Dizziness 627.88 11.89 3132 807117 343237 49451638
Anaemia 621.35 11.89 2023 808226 250433 49544442
Hepatic enzyme increased 620.93 11.89 4045 806204 133335 49661540
Bradycardia 612.43 11.89 140 810109 64286 49730589
Arthritis 595.74 11.89 2859 807390 83862 49711013
Cardiac arrest 571.98 11.89 313 809936 83338 49711537
Electrocardiogram QT prolonged 570.96 11.89 77 810172 51809 49743066
Abdominal discomfort 568.66 11.89 5938 804311 225703 49569172
Swelling 563.27 11.89 5294 804955 195578 49599297
Multiple sclerosis relapse 561.08 11.89 31 810218 42933 49751942
C-reactive protein increased 560.15 11.89 2329 807920 64145 49730730
Tremor 557.28 11.89 610 809639 114293 49680582
Mouth ulceration 549.18 11.89 1316 808933 26708 49768167
Red blood cell sedimentation rate increased 543.06 11.89 1350 808899 28066 49766809
Overdose 539.39 11.89 481 809768 99246 49695629
Anxiety 494.57 11.89 1343 808906 176263 49618612
Diarrhoea 494.28 11.89 6554 803695 581922 49212953
Hyperkalaemia 493.55 11.89 87 810162 48002 49746873
Gastrointestinal disorder 491.82 11.89 2885 807364 91571 49703304
Toxicity to various agents 490.56 11.89 1750 808499 210749 49584126
Red blood cell sedimentation rate abnormal 487.36 11.89 911 809338 15432 49779443
Cardio-respiratory arrest 487.15 11.89 130 810119 53762 49741113
Peripheral swelling 466.15 11.89 5195 805054 200741 49594134
Injection site pain 462.43 11.89 3204 807045 107820 49687055
Decreased appetite 459.54 11.89 1661 808588 199262 49595613
Loss of personal independence in daily activities 448.60 11.89 2264 807985 67786 49727089
Condition aggravated 440.67 11.89 6938 803311 290120 49504755
Joint stiffness 439.41 11.89 1272 808977 29036 49765839
Agitation 433.70 11.89 156 810093 53228 49741647
Inflammation 431.05 11.89 1931 808318 54981 49739894
Exposure during pregnancy 429.84 11.89 801 809448 120214 49674661
Device expulsion 425.28 11.89 7 810242 28815 49766060
Asthenia 424.74 11.89 3177 807072 315865 49479010
Hallucination 422.75 11.89 112 810137 46545 49748330
Systemic lupus erythematosus 422.65 11.89 3763 806486 136859 49658016
Drug interaction 417.38 11.89 1711 808538 197910 49596965
Pancytopenia 417.18 11.89 2535 807714 81495 49713380
Depressed level of consciousness 415.00 11.89 156 810093 51797 49743078
Hypokalaemia 413.63 11.89 479 809770 87513 49707362
Oedema peripheral 404.20 11.89 1243 809006 156718 49638157
Seizure 403.12 11.89 798 809451 117076 49677799
Cardiac failure congestive 402.45 11.89 454 809795 83928 49710947
International normalised ratio increased 401.73 11.89 98 810151 43054 49751821
Fall 397.64 11.89 3440 806809 331492 49463383
Suicide attempt 395.74 11.89 166 810083 51566 49743309
Injection site reaction 394.37 11.89 1718 808531 48314 49746561
Hypoglycaemia 389.36 11.89 185 810064 53396 49741479
Syncope 388.12 11.89 657 809592 102345 49692530
Sedation 376.43 11.89 30 810219 30580 49764295
Rhabdomyolysis 372.49 11.89 84 810165 38943 49755932
Pneumocystis jirovecii pneumonia 372.43 11.89 764 809485 13899 49780976
Malignant neoplasm progression 371.39 11.89 326 809923 67798 49727077
Hand deformity 369.07 11.89 2808 807441 97391 49697484
Rheumatoid nodule 365.00 11.89 698 809551 12037 49782838
Balance disorder 354.17 11.89 364 809885 70226 49724649
Diffuse large B-cell lymphoma 339.50 11.89 436 809813 5226 49789649
Lactic acidosis 338.68 11.89 62 810187 33293 49761582
Tuberculosis 337.48 11.89 591 809658 9492 49785383
Foot deformity 337.19 11.89 865 809384 18345 49776530
Confusional state 333.99 11.89 1685 808564 184243 49610632
Product use issue 328.51 11.89 3750 806499 145725 49649150
Tachycardia 327.81 11.89 691 809558 99072 49695803
Lower respiratory tract infection 326.87 11.89 2625 807624 92576 49702299
Haemoglobin decreased 324.70 11.89 1002 809247 126214 49668661
Muscle spasms 319.67 11.89 990 809259 124563 49670312
Osteoarthritis 318.13 11.89 2034 808215 66572 49728303
Coma 312.69 11.89 270 809979 56609 49738266
Fluid retention 312.07 11.89 214 810035 50435 49744440
Pemphigus 308.34 11.89 3110 807139 117056 49677819
Therapeutic response decreased 306.17 11.89 1532 808717 45699 49749176
Drug withdrawal syndrome 304.49 11.89 26 810223 25055 49769820
Hospitalisation 301.11 11.89 387 809862 67550 49727325
Product dose omission issue 300.84 11.89 1719 808530 182119 49612756
Blood glucose increased 297.22 11.89 425 809824 70899 49723976
Mobility decreased 295.18 11.89 2242 808007 77706 49717169
Platelet count decreased 292.07 11.89 746 809503 99980 49694895
Respiratory arrest 291.63 11.89 62 810187 29947 49764928
Rheumatoid factor positive 291.21 11.89 1571 808678 48288 49746587
Metabolic acidosis 286.80 11.89 131 810118 38694 49756181
Bone erosion 284.00 11.89 598 809651 11089 49783786
Intentional self-injury 283.23 11.89 23 810226 23089 49771786
Interstitial lung disease 281.68 11.89 1632 808617 51544 49743331
Gastrointestinal haemorrhage 276.78 11.89 467 809782 72854 49722021
Serotonin syndrome 275.88 11.89 35 810214 24678 49770197
Sopor 273.74 11.89 10 810239 19869 49775006
Nasopharyngitis 273.52 11.89 4474 805775 188453 49606422
Chest pain 272.45 11.89 1686 808563 175196 49619679
Acute graft versus host disease 269.72 11.89 325 809924 3633 49791242
Orthostatic hypotension 268.53 11.89 70 810179 29411 49765464
Pain in extremity 266.43 11.89 5976 804273 266889 49527986
Hyperhidrosis 264.94 11.89 655 809594 88771 49706104
Nodule 264.39 11.89 732 809517 16271 49778604
Musculoskeletal pain 261.92 11.89 2016 808233 70161 49724714
Joint range of motion decreased 259.74 11.89 768 809481 17744 49777131
Stomatitis 257.59 11.89 2618 807631 98726 49696149
Unresponsive to stimuli 256.27 11.89 85 810164 30524 49764351
Epstein Barr virus positive mucocutaneous ulcer 251.34 11.89 124 810125 271 49794604
Herpes zoster 250.68 11.89 1966 808283 68820 49726055
Chest discomfort 250.51 11.89 711 809538 92011 49702864
Finger deformity 249.99 11.89 377 809872 5305 49789570
Cognitive disorder 249.22 11.89 204 810045 43919 49750956
Renal failure 245.18 11.89 879 809370 105754 49689121
Product quality issue 242.54 11.89 95 810154 30763 49764112
Basal cell carcinoma 240.39 11.89 872 809377 22484 49772391
Vomiting 238.74 11.89 5589 804660 455169 49339706
Pulmonary fibrosis 238.64 11.89 897 809352 23540 49771335
Drug reaction with eosinophilia and systemic symptoms 236.11 11.89 80 810169 28344 49766531
Knee arthroplasty 234.63 11.89 1166 809083 34680 49760195
Neuropathy peripheral 232.96 11.89 782 809467 95975 49698900
Hypoxia 231.98 11.89 286 809963 50837 49744038
Grip strength decreased 231.85 11.89 564 809685 11557 49783318
Epstein-Barr virus associated lymphoproliferative disorder 229.24 11.89 201 810048 1488 49793387
Cerebrovascular accident 228.09 11.89 765 809484 93915 49700960
Leukoencephalopathy 220.34 11.89 291 809958 3592 49791283
Vision blurred 219.19 11.89 594 809655 78053 49716822
Flushing 218.57 11.89 466 809783 66549 49728326
Disease progression 216.58 11.89 796 809453 95070 49699805
Pulmonary tuberculosis 216.35 11.89 303 809946 3970 49790905
Suicidal ideation 216.26 11.89 345 809904 55040 49739835
Loss of consciousness 216.24 11.89 897 809352 103456 49691419
Epstein-Barr virus infection 214.83 11.89 395 809854 6602 49788273
Musculoskeletal disorder 214.78 11.89 689 809560 16660 49778215
Lymphoma 213.54 11.89 474 809775 9127 49785748
Pulmonary embolism 212.76 11.89 871 809378 100833 49694042
Impaired healing 211.74 11.89 1872 808377 67914 49726961
Sinusitis 209.85 11.89 3867 806382 166691 49628184
Injection site erythema 208.53 11.89 1973 808276 72963 49721912
Foetal exposure during pregnancy 207.29 11.89 89 810160 27270 49767605
White blood cell count decreased 204.79 11.89 1066 809183 115656 49679219
Blood potassium decreased 204.72 11.89 174 810075 36771 49758104
Full blood count decreased 203.63 11.89 53 810196 22293 49772582
Dysgeusia 201.68 11.89 195 810054 38721 49756154
Glossodynia 201.31 11.89 2777 807472 112792 49682083
Myalgia 200.80 11.89 1167 809082 123152 49671723
Disorientation 200.47 11.89 164 810085 35320 49759555
Injection site bruising 200.30 11.89 1137 809112 35631 49759244
Dyspnoea exertional 200.17 11.89 319 809930 50914 49743961
Plasma cell myeloma 200.17 11.89 127 810122 31195 49763680
Cardiac failure 199.60 11.89 591 809658 75449 49719426
Mental status changes 198.35 11.89 173 810076 36099 49758776
Premature delivery 192.42 11.89 69 810180 23594 49771281
Ankylosing spondylitis 192.28 11.89 382 809867 6783 49788092
Palpitations 191.08 11.89 820 809429 93686 49701189
Depression 190.96 11.89 1710 808539 163713 49631162
Atrial fibrillation 188.31 11.89 912 809337 100833 49694042
Blood pressure decreased 187.17 11.89 383 809866 55526 49739349
Mucosal inflammation 185.94 11.89 1190 809059 38952 49755923
Restlessness 181.20 11.89 88 810161 25085 49769790
Abdominal pain 180.79 11.89 2677 807572 233551 49561324
Pulmonary hypertension 180.78 11.89 161 810088 33256 49761619
Skin ulcer 180.58 11.89 1074 809175 34244 49760631
Hypomagnesaemia 179.18 11.89 73 810176 23083 49771792
Gastrooesophageal reflux disease 178.33 11.89 626 809623 75802 49719073
Hypervolaemia 177.75 11.89 93 810156 25406 49769469
Dyskinesia 176.62 11.89 114 810135 27747 49767128
Fear of injection 175.49 11.89 335 809914 5768 49789107
Pulmonary oedema 175.34 11.89 322 809927 48616 49746259
Hypersensitivity 174.97 11.89 4597 805652 210564 49584311
Pneumonia aspiration 173.04 11.89 145 810104 30859 49764016
Lethargy 170.30 11.89 333 809916 49099 49745776
Tuberculin test positive 168.93 11.89 231 810018 2955 49791920
Device dislocation 168.23 11.89 67 810182 21479 49773396
Withdrawal syndrome 167.56 11.89 38 810211 17552 49777323
Lung disorder 166.78 11.89 1259 808990 43540 49751335
Wheezing 166.65 11.89 477 809772 61570 49733305
Chronic graft versus host disease 166.00 11.89 217 810032 2650 49792225
Breast cancer 165.14 11.89 1215 809034 41675 49753200
Injection site pruritus 164.97 11.89 1161 809088 39250 49755625
Blood calcium decreased 163.96 11.89 63 810186 20643 49774232
Uveitis 163.14 11.89 419 809830 8891 49785984
Arthritis bacterial 161.88 11.89 309 809940 5320 49789555
Aggression 161.08 11.89 68 810181 21048 49773827
Palmar-plantar erythrodysaesthesia syndrome 161.06 11.89 60 810189 20038 49774837
Hyperglycaemia 160.64 11.89 208 810041 36197 49758678
Angiocentric lymphoma 160.55 11.89 104 810145 452 49794423
Joint destruction 159.88 11.89 251 809998 3665 49791210
Caesarean section 158.91 11.89 29 810220 15610 49779265
Abnormal behaviour 158.69 11.89 58 810191 19600 49775275
Blood alkaline phosphatase increased 156.90 11.89 223 810026 37303 49757572
Anti-cyclic citrullinated peptide antibody positive 153.56 11.89 1768 808481 68819 49726056
Disturbance in attention 150.58 11.89 166 810083 31020 49763855
Dysphagia 149.79 11.89 684 809565 76834 49718041
Joint effusion 149.43 11.89 504 809745 12517 49782358
Pulmonary arterial hypertension 149.37 11.89 69 810180 20250 49774625
Neuroleptic malignant syndrome 148.56 11.89 7 810242 11123 49783752
Epistaxis 148.41 11.89 525 809724 63429 49731446
Neutrophil count decreased 145.97 11.89 325 809924 45701 49749174
Asthma 145.08 11.89 837 809412 88500 49706375
Hallucination, visual 144.25 11.89 43 810206 16539 49778336
Blood iron abnormal 143.94 11.89 219 810030 3107 49791768
B-cell lymphoma 142.77 11.89 206 810043 2779 49792096
Respiratory depression 141.64 11.89 14 810235 11996 49782879
Juvenile idiopathic arthritis 141.10 11.89 201 810048 2678 49792197
Dactylitis 140.42 11.89 161 810088 1700 49793175
Tenosynovitis 140.37 11.89 430 809819 10135 49784740
Delirium 139.77 11.89 248 810001 37944 49756931
Disseminated tuberculosis 138.63 11.89 187 810062 2359 49792516
Emotional distress 136.83 11.89 154 810095 28509 49766366
Premature baby 136.78 11.89 61 810188 18276 49776599
Blood creatinine increased 136.68 11.89 690 809559 75470 49719405
Torsade de pointes 136.47 11.89 15 810234 11820 49783055
Infusion related reaction 136.40 11.89 3618 806631 165939 49628936
Oedema 136.35 11.89 618 809631 69563 49725312
Psychotic disorder 135.89 11.89 91 810158 21721 49773154
Diabetic ketoacidosis 135.61 11.89 58 810191 17814 49777061
Pulmonary toxicity 135.60 11.89 285 809964 5277 49789598
Deep vein thrombosis 135.07 11.89 658 809591 72646 49722229
Right ventricular failure 135.04 11.89 43 810206 15850 49779025
Sinus bradycardia 134.92 11.89 24 810225 13159 49781716
Deformity 134.67 11.89 353 809896 7587 49787288
Injection site swelling 133.16 11.89 1133 809116 40640 49754235
Folliculitis 132.02 11.89 1077 809172 38148 49756727
Rash 131.65 11.89 8399 801850 429072 49365803
Wound 131.51 11.89 2403 807846 103391 49691484
Blood urea increased 130.76 11.89 111 810138 23474 49771401
Disability 130.64 11.89 476 809773 12299 49782576
Fine motor skill dysfunction 130.24 11.89 235 810014 3868 49791007
Creatinine renal clearance decreased 129.81 11.89 18 810231 11863 49783012
Angioedema 129.61 11.89 254 809995 37422 49757453
Myoclonus 128.68 11.89 36 810213 14434 49780441
Pulmonary mass 128.51 11.89 617 809632 18088 49776787
Lymphocyte count decreased 127.05 11.89 140 810109 26167 49768708
Histoplasmosis disseminated 126.48 11.89 128 810121 1158 49793717
Febrile bone marrow aplasia 126.44 11.89 299 809950 6012 49788863
Heart rate increased 126.37 11.89 722 809527 76528 49718347
Insomnia 126.05 11.89 2004 808245 172861 49622014
Malignant melanoma 125.63 11.89 402 809847 9706 49785169
Contraindication to medical treatment 125.00 11.89 93 810156 527 49794348
Irritability 124.81 11.89 163 810086 28263 49766612
Blood creatine phosphokinase increased 124.41 11.89 143 810106 26224 49768651
Ill-defined disorder 124.32 11.89 1381 808868 53273 49741602
Urinary retention 123.62 11.89 142 810107 26048 49768827
Osteoporosis 123.50 11.89 1179 809070 43700 49751175
Arrhythmia 121.37 11.89 215 810034 32917 49761958
Melaena 121.11 11.89 151 810098 26713 49768162
Intentional product misuse 120.62 11.89 366 809883 46368 49748507
Fibromyalgia 119.54 11.89 1173 809076 43805 49751070
Nightmare 119.22 11.89 54 810195 16032 49778843
Pustular psoriasis 118.78 11.89 222 810027 3759 49791116
Blood sodium decreased 117.89 11.89 99 810150 21048 49773827
Memory impairment 117.64 11.89 765 809484 78595 49716280
Abortion spontaneous 117.48 11.89 314 809935 41458 49753417
Muscle twitching 117.21 11.89 50 810199 15381 49779494
Acute graft versus host disease in skin 117.10 11.89 189 810060 2829 49792046
Extrapyramidal disorder 117.09 11.89 23 810226 11747 49783128
Ventricular tachycardia 115.87 11.89 54 810195 15767 49779108
Paraesthesia 114.60 11.89 1301 808948 118942 49675933
Acute respiratory failure 114.52 11.89 177 810072 28605 49766270
Tubulointerstitial nephritis 114.41 11.89 50 810199 15161 49779714
Muscle injury 113.81 11.89 998 809251 36113 49758762
Dystonia 113.13 11.89 26 810223 11900 49782975
Neoplasm progression 112.51 11.89 183 810066 28974 49765901
Coronary artery disease 112.45 11.89 189 810060 29537 49765338
Poisoning 112.26 11.89 30 810219 12399 49782476
Thrombocytopenia 111.50 11.89 1408 808841 126265 49668610
Arthrodesis 110.92 11.89 166 810083 2319 49792556
Adverse reaction 110.86 11.89 346 809903 8240 49786635
Lupus-like syndrome 110.36 11.89 369 809880 9122 49785753
Mania 109.29 11.89 21 810228 10895 49783980
Panniculitis 109.19 11.89 342 809907 8161 49786714
Drug clearance decreased 108.71 11.89 112 810137 1037 49793838
Thrombosis 108.24 11.89 492 809757 55341 49739534
Myocardial infarction 108.10 11.89 908 809341 88119 49706756
Urinary tract infection 108.02 11.89 2745 807504 221275 49573600
Parkinsonism 107.86 11.89 9 810240 8838 49786037
Rash maculo-papular 107.76 11.89 162 810087 26479 49768396
Immunosuppression 106.95 11.89 311 809938 7115 49787760
Blood bilirubin increased 106.77 11.89 220 810029 31818 49763057
Bone pain 106.72 11.89 392 809857 46837 49748038
Impaired work ability 106.37 11.89 467 809782 13173 49781702
Hypocalcaemia 105.65 11.89 166 810083 26650 49768225
Acute myocardial infarction 105.39 11.89 192 810057 29081 49765794
Diverticulitis 105.23 11.89 899 809350 32283 49762592
Chronic kidney disease 105.14 11.89 308 809941 39463 49755412
Anhedonia 105.07 11.89 14 810235 9510 49785365
Sinus tachycardia 104.94 11.89 112 810137 21242 49773633
Mycobacterium tuberculosis complex test positive 104.32 11.89 135 810114 1631 49793244
Akathisia 104.22 11.89 7 810242 8222 49786653
Polyarthritis 103.79 11.89 321 809928 7606 49787269
Premature labour 103.08 11.89 28 810221 11448 49783427
Cardiac disorder 102.95 11.89 348 809901 42631 49752244
Circulatory collapse 102.71 11.89 101 810148 19899 49774976
Transfusion 102.62 11.89 39 810210 12866 49782009
Deafness transitory 102.53 11.89 135 810114 1661 49793214
Upper gastrointestinal haemorrhage 102.47 11.89 65 810184 15970 49778905
Dysarthria 101.56 11.89 286 809963 37117 49757758
Electrolyte imbalance 101.21 11.89 76 810173 17093 49777782
Speech disorder 100.88 11.89 266 809983 35282 49759593
Haemophagocytic lymphohistiocytosis 100.69 11.89 336 809913 8297 49786578
Abdominal distension 100.48 11.89 718 809531 72185 49722690
Pericarditis 100.46 11.89 1795 808454 76894 49717981
Cholecystitis chronic 100.27 11.89 17 810232 9652 49785223
Rheumatoid lung 99.26 11.89 157 810092 2308 49792567
Demyelination 98.24 11.89 264 809985 5762 49789113
Injection site warmth 97.89 11.89 461 809788 13405 49781470
Hip arthroplasty 96.80 11.89 825 809424 29604 49765271
Venoocclusive liver disease 96.60 11.89 212 810037 4049 49790826
Pregnancy 96.13 11.89 206 810043 29371 49765504
Presyncope 96.09 11.89 149 810100 24049 49770826
Infusion site pain 95.39 11.89 39 810210 12307 49782568
Hypothermia 94.41 11.89 37 810212 11979 49782896
Shoulder arthroplasty 93.93 11.89 185 810064 3263 49791612
Foot operation 93.48 11.89 245 810004 5265 49789610
Dry skin 93.36 11.89 365 809884 42826 49752049
Cardiogenic shock 93.31 11.89 68 810181 15531 49779344
Latent tuberculosis 93.29 11.89 145 810104 2098 49792777
Haemorrhage 92.58 11.89 490 809759 52951 49741924
Head injury 92.45 11.89 151 810098 23869 49771006
Blood glucose decreased 92.33 11.89 93 810156 18118 49776757
Full blood count abnormal 91.93 11.89 145 810104 23243 49771632
Flatulence 90.17 11.89 212 810037 29246 49765629
Obstructive airways disorder 90.08 11.89 71 810178 15581 49779294
Irritable bowel syndrome 89.85 11.89 1237 809012 50204 49744671
Bone marrow failure 89.49 11.89 752 809497 26872 49768003
Altered state of consciousness 88.84 11.89 133 810116 21777 49773098
Chills 88.66 11.89 1055 809194 95632 49699243
Muscle rigidity 88.25 11.89 24 810225 9805 49785070
Sensitivity to weather change 88.05 11.89 253 809996 5748 49789127
Hallucination, auditory 86.01 11.89 32 810217 10696 49784179
Product substitution issue 85.76 11.89 60 810189 13997 49780878
Acute hepatic failure 85.43 11.89 75 810174 15602 49779273
Neutropenia 85.37 11.89 1763 808486 146202 49648673
Mucosal ulceration 85.32 11.89 86 810163 774 49794101
Joint arthroplasty 85.18 11.89 135 810114 1988 49792887
Oxygen saturation decreased 84.94 11.89 756 809493 72492 49722383
Chronic obstructive pulmonary disease 84.93 11.89 504 809745 52931 49741944
Paranoia 84.43 11.89 30 810219 10318 49784557
Wrong technique in product usage process 84.35 11.89 531 809718 54979 49739896
Urinary incontinence 83.97 11.89 206 810043 28002 49766873
Delusion 83.94 11.89 32 810217 10537 49784338
Immobile 82.98 11.89 222 810027 4832 49790043
Feeling abnormal 82.59 11.89 1462 808787 124030 49670845
Cerebral haemorrhage 82.55 11.89 195 810054 26857 49768018
Blood magnesium decreased 81.87 11.89 38 810211 11122 49783753
Hepatotoxicity 80.30 11.89 726 809523 26500 49768375
Jaundice 80.26 11.89 191 810058 26238 49768637
Complication associated with device 79.99 11.89 70 810179 14585 49780290
Complication of device insertion 79.99 11.89 4 810245 6037 49788838
Hodgkin's disease 79.78 11.89 80 810169 715 49794160
Injury 79.60 11.89 458 809791 48467 49746408
Tardive dyskinesia 79.59 11.89 11 810238 7268 49787607
Swollen tongue 79.15 11.89 217 810032 28413 49766462
Hospice care 79.14 11.89 3 810246 5769 49789106
Schizophrenia 78.97 11.89 12 810237 7385 49787490
Haematocrit decreased 78.56 11.89 291 809958 34685 49760190
Hypofibrinogenaemia 78.55 11.89 93 810156 1019 49793856
Mental disorder 78.49 11.89 145 810104 21846 49773029
Synovial cyst 78.27 11.89 298 809951 7868 49787007
Foetal methotrexate syndrome 78.09 11.89 35 810214 55 49794820
Stevens-Johnson syndrome 78.01 11.89 143 810106 21609 49773266
Elbow deformity 77.30 11.89 103 810146 1283 49793592
Status epilepticus 76.92 11.89 61 810188 13345 49781530
Rectal haemorrhage 76.40 11.89 337 809912 38221 49756654
Ulcer 75.90 11.89 569 809680 19631 49775244
Atrial septal defect 75.81 11.89 7 810242 6334 49788541
Haematemesis 75.27 11.89 212 810037 27513 49767362
Hepatitis B reactivation 74.66 11.89 126 810123 1961 49792914
Graft versus host disease 74.61 11.89 243 810006 5923 49788952
Haematoma 74.47 11.89 245 810004 30265 49764610
Pleural effusion 74.21 11.89 890 809359 80564 49714311
Myelopathy 74.16 11.89 141 810108 2420 49792455
Pharyngitis 73.85 11.89 507 809742 16996 49777879
Limb deformity 73.82 11.89 176 810073 3558 49791317
Product administration error 73.81 11.89 126 810123 19573 49775302
Respiratory failure 73.57 11.89 1022 809227 90159 49704716
Abnormal dreams 73.46 11.89 29 810220 9348 49785527
Infusion site erythema 73.46 11.89 24 810225 8703 49786172
Adverse drug reaction 73.07 11.89 1267 808982 53955 49740920
Dementia 73.07 11.89 89 810160 15908 49778967
Oral herpes 72.97 11.89 575 809674 20150 49774725
Musculoskeletal deformity 72.76 11.89 84 810165 894 49793981
Electrocardiogram QRS complex prolonged 72.52 11.89 3 810246 5341 49789534
Respiratory distress 72.25 11.89 248 810001 30241 49764634
Depressed mood 71.96 11.89 290 809959 33733 49761142
Leukocytosis 71.94 11.89 159 810090 22420 49772455
Atrioventricular block first degree 71.14 11.89 8 810241 6193 49788682
Generalised tonic-clonic seizure 70.82 11.89 202 810047 26108 49768767
Discomfort 70.69 11.89 2253 807996 106127 49688748
Sleep apnoea syndrome 70.50 11.89 175 810074 23693 49771182
Off label use 70.37 11.89 8648 801601 465778 49329097
Sleep disorder due to general medical condition, insomnia type 70.31 11.89 792 809457 30655 49764220
Eosinophilia 70.17 11.89 119 810130 18533 49776342
Red blood cell count decreased 69.93 11.89 291 809958 33544 49761331
Ejection fraction decreased 69.82 11.89 118 810131 18402 49776473
Uterine perforation 69.42 11.89 10 810239 6405 49788470
Histoplasmosis 69.40 11.89 111 810138 1648 49793227
Infusion site swelling 69.36 11.89 15 810234 7161 49787714
Sleep disorder 69.34 11.89 1296 808953 55987 49738888
Moebius II syndrome 68.84 11.89 23 810226 4 49794871
Lip swelling 68.75 11.89 187 810062 24549 49770326
Ventricular extrasystoles 68.07 11.89 42 810207 10474 49784401
Atrioventricular block 68.04 11.89 11 810238 6467 49788408
Atypical mycobacterial infection 67.79 11.89 75 810174 759 49794116
Enthesopathy 67.71 11.89 261 809988 6932 49787943
Haematotoxicity 67.52 11.89 278 809971 7617 49787258
Localised infection 66.90 11.89 663 809586 24822 49770053
Gamma-glutamyltransferase increased 66.83 11.89 246 810003 29377 49765498
Spinal stenosis 66.66 11.89 408 809841 13142 49781733
Hepatic fibrosis 66.66 11.89 154 810095 3048 49791827
Mydriasis 66.65 11.89 44 810205 10583 49784292
Granuloma skin 66.58 11.89 225 810024 5593 49789282
Ascites 65.98 11.89 322 809927 35539 49759336
Pollakiuria 65.77 11.89 181 810068 23670 49771205
Mucocutaneous ulceration 65.74 11.89 38 810211 128 49794747
Diabetes mellitus inadequate control 65.65 11.89 68 810181 13077 49781798
Transplant rejection 65.57 11.89 36 810213 9573 49785302
Epicondylitis 65.32 11.89 113 810136 1796 49793079
Joint injury 64.76 11.89 582 809667 21207 49773668
Cyanosis 64.69 11.89 89 810160 15095 49779780
Swelling face 64.47 11.89 535 809714 52060 49742815
Bronchitis chronic 64.36 11.89 171 810078 3706 49791169
Epidermal necrosis 64.04 11.89 76 810173 835 49794040
Injection site haemorrhage 63.87 11.89 571 809678 20775 49774100
Treatment noncompliance 63.76 11.89 257 809992 29893 49764982
Neuroendocrine carcinoma of the skin 63.72 11.89 56 810193 416 49794459
Inflammatory marker increased 63.70 11.89 217 810032 5417 49789458
Joint dislocation 63.64 11.89 376 809873 11957 49782918
Fear 63.28 11.89 84 810165 14465 49780410
Hepatic encephalopathy 63.05 11.89 38 810211 9598 49785277
Somnambulism 62.92 11.89 4 810245 4920 49789955
Tricuspid valve incompetence 62.72 11.89 67 810182 12703 49782172
Pallor 62.53 11.89 178 810071 23021 49771854
Anuria 62.23 11.89 53 810196 11191 49783684
Gestational diabetes 62.01 11.89 21 810228 7444 49787431
Device difficult to use 61.91 11.89 41 810208 9845 49785030
Wrist deformity 61.79 11.89 107 810142 1702 49793173
Product use in unapproved indication 61.63 11.89 2352 807897 113467 49681408
Lymph node tuberculosis 61.47 11.89 68 810181 688 49794187
Hepatic steatosis 61.43 11.89 629 809620 23755 49771120
Retinal toxicity 61.28 11.89 85 810164 1103 49793772
Aphthous ulcer 61.22 11.89 333 809916 10264 49784611
Hot flush 60.85 11.89 435 809814 43734 49751141
Hypothyroidism 60.73 11.89 310 809939 33815 49761060
Dialysis 60.67 11.89 38 810211 9400 49785475
Renal injury 60.62 11.89 31 810218 8580 49786295
Retching 60.41 11.89 70 810179 12792 49782083
Acute generalised exanthematous pustulosis 60.25 11.89 34 810215 8904 49785971
X-ray abnormal 60.18 11.89 132 810117 2520 49792355
Investigation abnormal 60.06 11.89 87 810162 1178 49793697
Therapy non-responder 59.92 11.89 1149 809100 49873 49745002
No adverse event 59.77 11.89 305 809944 33273 49761602
Chromaturia 59.70 11.89 88 810161 14502 49780373
Dysuria 59.63 11.89 244 810005 28260 49766615
Pre-eclampsia 59.62 11.89 27 810222 8017 49786858
Hypomania 59.59 11.89 3 810246 4502 49790373
Pulseless electrical activity 59.03 11.89 18 810231 6823 49788052
Transient ischaemic attack 58.80 11.89 290 809959 31920 49762955
Hypophosphataemia 58.18 11.89 31 810218 8383 49786492
Haemoptysis 57.93 11.89 212 810037 25361 49769514
Psychomotor hyperactivity 57.67 11.89 39 810210 9262 49785613
Product complaint 57.62 11.89 59 810190 11407 49783468
Pneumonia cryptococcal 57.36 11.89 61 810188 588 49794287
Skin cancer 56.86 11.89 299 809950 9095 49785780
Lennox-Gastaut syndrome 56.86 11.89 42 810207 235 49794640
Drug dependence 56.71 11.89 147 810102 19612 49775263
Lung adenocarcinoma 56.55 11.89 170 810079 3964 49790911
Pneumonitis 56.24 11.89 721 809528 28789 49766086
Visceral leishmaniasis 56.10 11.89 53 810196 437 49794438
Incorrect product administration duration 56.04 11.89 40 810209 9235 49785640
Rheumatoid factor negative 55.89 11.89 58 810191 542 49794333
Drug tolerance decreased 55.75 11.89 292 809957 8868 49786007
Ageusia 55.53 11.89 62 810187 11521 49783354
Scleritis 55.27 11.89 144 810105 3083 49791792
Tonsillitis 55.12 11.89 189 810060 4734 49790141
Body height below normal 54.83 11.89 106 810143 1843 49793032
Ventricular fibrillation 54.59 11.89 53 810196 10506 49784369
Unevaluable event 54.48 11.89 473 809776 45593 49749282
Acidosis 54.44 11.89 50 810199 10177 49784698
Hypovolaemia 54.39 11.89 43 810206 9422 49785453
Ankle deformity 54.25 11.89 49 810200 379 49794496
Temporal lobe epilepsy 54.21 11.89 46 810203 324 49794551
Inappropriate antidiuretic hormone secretion 54.05 11.89 79 810170 13064 49781811
Salivary hypersecretion 53.96 11.89 19 810230 6572 49788303
Product physical issue 53.95 11.89 4 810245 4328 49790547
Toxic epidermal necrolysis 53.73 11.89 165 810084 20827 49774048
SLE arthritis 53.54 11.89 58 810191 572 49794303
Acute graft versus host disease in intestine 53.46 11.89 95 810154 1544 49793331
Blood potassium increased 53.46 11.89 114 810135 16284 49778591
Epilepsy 53.46 11.89 172 810077 21395 49773480
Nervousness 53.38 11.89 244 810005 27407 49767468
Joint noise 53.38 11.89 152 810097 3435 49791440
Haemorrhage intracranial 53.25 11.89 72 810177 12302 49782573
Device use error 53.00 11.89 10 810239 5256 49789619
Blood parathyroid hormone decreased 52.78 11.89 240 810009 6874 49788001
Muscle tightness 52.69 11.89 52 810197 10228 49784647
Gastrointestinal pain 52.66 11.89 262 809987 7794 49787081
Acute lymphocytic leukaemia recurrent 52.64 11.89 105 810144 1870 49793005
Stillbirth 52.57 11.89 15 810234 5937 49788938
Metastases to bone 52.32 11.89 133 810116 17862 49777013
Mood altered 52.31 11.89 77 810172 12696 49782179
Epstein-Barr virus associated lymphoma 52.31 11.89 50 810199 419 49794456
Blood loss anaemia 52.00 11.89 33 810216 8106 49786769
Transaminases increased 51.84 11.89 677 809572 27147 49767728
Glycosylated haemoglobin increased 51.70 11.89 56 810193 10550 49784325
Device breakage 51.63 11.89 46 810203 9501 49785374
Skin necrosis 51.45 11.89 324 809925 10543 49784332
Cytokine release syndrome 51.17 11.89 38 810211 8596 49786279
Graft versus host disease in skin 51.10 11.89 121 810128 2435 49792440
Hyperlipidaemia 51.06 11.89 129 810120 17361 49777514
Aspartate aminotransferase increased 50.87 11.89 910 809339 77088 49717787
Liver function test abnormal 50.87 11.89 995 809254 43344 49751531
Paraesthesia oral 50.71 11.89 73 810176 12148 49782727
Sarcoidosis 50.51 11.89 186 810063 4831 49790044
Pregnancy with contraceptive device 50.14 11.89 4 810245 4075 49790800
Non-Hodgkin's lymphoma 50.01 11.89 84 810165 1302 49793573
Respiratory acidosis 50.00 11.89 17 810232 6011 49788864
Bradyphrenia 49.91 11.89 18 810231 6134 49788741
Anger 49.73 11.89 65 810184 11268 49783607
Supraventricular tachycardia 49.71 11.89 80 810169 12721 49782154
Liver disorder 49.59 11.89 855 809394 36367 49758508
Pneumonia legionella 49.22 11.89 82 810167 1262 49793613
Pleurisy 49.05 11.89 240 810009 7091 49787784
Rheumatoid factor increased 48.99 11.89 84 810165 1325 49793550
Metabolic encephalopathy 48.90 11.89 11 810238 5110 49789765
Genital haemorrhage 48.82 11.89 22 810227 6552 49788323
Wrist surgery 48.71 11.89 62 810187 736 49794139
Eye disorder 48.46 11.89 486 809763 18253 49776622
Onychomycosis 48.32 11.89 184 810065 4858 49790017
Renal impairment 48.01 11.89 887 809362 74774 49720101
Chronic graft versus host disease in skin 47.98 11.89 57 810192 627 49794248
Panic attack 47.42 11.89 155 810094 19187 49775688
Hyperthyroidism 47.36 11.89 76 810173 12099 49782776
Face oedema 47.25 11.89 138 810111 17701 49777174
Normal newborn 47.23 11.89 24 810225 6667 49788208
Thinking abnormal 47.21 11.89 50 810199 9517 49785358
Forced expiratory volume decreased 47.20 11.89 7 810242 4387 49790488
Blister 47.20 11.89 1742 808507 83676 49711199
Helicobacter infection 47.19 11.89 1085 809164 48617 49746258
Adult T-cell lymphoma/leukaemia 47.03 11.89 34 810215 183 49794692
Tachypnoea 46.97 11.89 102 810147 14475 49780400
Osteonecrosis of jaw 46.94 11.89 316 809933 32210 49762665
Ear infection 46.77 11.89 628 809621 25342 49769533
Hypoaesthesia oral 46.60 11.89 62 810187 10666 49784209
Vertigo 46.56 11.89 568 809681 51264 49743611
Hypersensitivity pneumonitis 46.51 11.89 110 810139 2212 49792663
Injection site rash 46.50 11.89 429 809820 15748 49779127
Troponin increased 46.50 11.89 37 810212 8081 49786794
Neck pain 46.46 11.89 1220 809029 55847 49739028
Injection site urticaria 46.39 11.89 345 809904 11872 49783003
Lung neoplasm malignant 46.22 11.89 414 809835 15070 49779805
Hypercapnia 46.12 11.89 9 810240 4618 49790257
Atrioventricular block second degree 46.09 11.89 3 810246 3618 49791257
Spinal column injury 45.88 11.89 94 810155 1708 49793167
Amyotrophic lateral sclerosis 45.81 11.89 70 810179 997 49793878
Lip ulceration 45.77 11.89 94 810155 1711 49793164
Synovectomy 45.68 11.89 31 810218 148 49794727
Nasal ulcer 45.48 11.89 90 810159 1593 49793282
Bradykinesia 45.46 11.89 5 810244 3938 49790937
Tinnitus 45.41 11.89 264 809985 27868 49767007
Underdose 45.35 11.89 169 810080 20109 49774766
Muscular weakness 45.23 11.89 1166 809083 93847 49701028
Aspiration 45.06 11.89 49 810200 9215 49785660
Hyperreflexia 45.01 11.89 13 810236 5105 49789770
Adenovirus infection 44.97 11.89 132 810117 3036 49791839
Renal tubular necrosis 44.95 11.89 58 810191 10110 49784765
Mycobacterium marinum infection 44.90 11.89 33 810216 183 49794692
Surgical failure 44.69 11.89 64 810185 857 49794018
Varicella zoster virus infection 44.63 11.89 113 810136 2376 49792499
Skin erosion 44.08 11.89 108 810141 2223 49792652
Hereditary angioedema 44.02 11.89 16 810233 5426 49789449
Neurotoxicity 43.94 11.89 394 809855 14346 49780529
Dry mouth 43.77 11.89 634 809615 55544 49739331
Pre-existing condition improved 43.68 11.89 30 810219 7067 49787808
Eye swelling 43.68 11.89 170 810079 19974 49774901
Amnesia 43.53 11.89 449 809800 41811 49753064
Heparin-induced thrombocytopenia 43.33 11.89 6 810243 3959 49790916
Organising pneumonia 43.13 11.89 171 810078 4603 49790272
Physical disability 43.13 11.89 93 810156 1754 49793121
Malignant respiratory tract neoplasm 42.99 11.89 20 810229 36 49794839
Hepatosplenic T-cell lymphoma 42.90 11.89 50 810199 538 49794337
Non-alcoholic steatohepatitis 42.78 11.89 80 810169 1355 49793520
Neutrophil count increased 42.77 11.89 103 810146 14092 49780783
Prothrombin time prolonged 42.71 11.89 47 810202 8791 49786084
Dermatitis allergic 42.65 11.89 349 809900 12371 49782504
Hip fracture 42.58 11.89 242 810007 25689 49769186
Catatonia 42.41 11.89 5 810244 3731 49791144
Adactyly 42.34 11.89 19 810230 30 49794845
Blood pressure fluctuation 42.15 11.89 807 809442 35016 49759859
Transaminases abnormal 42.06 11.89 49 810200 527 49794348
Encephalitis 42.02 11.89 231 810018 7149 49787726
Clonus 41.87 11.89 8 810241 4167 49790708
Cholelithiasis 41.81 11.89 397 809852 37576 49757299
Shock 41.81 11.89 179 810070 20471 49774404
Personality change 41.75 11.89 19 810230 5626 49789249
Erythema multiforme 41.71 11.89 50 810199 9000 49785875
Low birth weight baby 41.66 11.89 21 810228 5860 49789015
Atrioventricular block complete 41.64 11.89 33 810216 7222 49787653
Exposure to toxic agent 41.27 11.89 5 810244 3653 49791222
Patent ductus arteriosus 41.23 11.89 6 810243 3814 49791061
Foetal death 41.21 11.89 42 810207 8138 49786737
Cholestasis 41.20 11.89 238 810011 25163 49769712
Lower gastrointestinal haemorrhage 41.13 11.89 30 810219 6849 49788026
Spondyloarthropathy 40.97 11.89 56 810193 716 49794159
Application site erythema 40.90 11.89 11 810238 4527 49790348
Mental impairment 40.73 11.89 82 810167 11962 49782913
Hypotonia 40.71 11.89 42 810207 8092 49786783
Infusion site pruritus 40.65 11.89 7 810242 3930 49790945
Urine output decreased 40.58 11.89 65 810184 10356 49784519
Oral mucosal exfoliation 40.49 11.89 82 810167 1477 49793398
Ovarian hyperstimulation syndrome 40.39 11.89 3 810246 3241 49791634
Pancreatitis acute 40.31 11.89 220 810029 23592 49771283
Induced abortion failed 40.26 11.89 32 810217 203 49794672
Vascular access complication 39.86 11.89 68 810181 1068 49793807
Hepatitis E 39.79 11.89 71 810178 1158 49793717
Blood calcium increased 39.61 11.89 39 810210 7680 49787195
Encephalopathy 39.48 11.89 347 809902 33364 49761511
Hepatic cirrhosis 39.43 11.89 443 809806 17134 49777741
Maternal drugs affecting foetus 39.29 11.89 16 810233 5061 49789814
Pericardial effusion 39.27 11.89 244 810005 25345 49769530
Intestinal obstruction 39.24 11.89 254 809995 26129 49768746
Cutaneous vasculitis 39.21 11.89 156 810093 4206 49790669
Dizziness postural 39.14 11.89 25 810224 6120 49788755
Sickle cell anaemia with crisis 39.12 11.89 12 810237 4531 49790344
Peritonitis bacterial 38.91 11.89 13 810236 4648 49790227
Catheter site erythema 38.87 11.89 8 810241 3954 49790921
Leukopenia 38.73 11.89 1383 808866 66145 49728730
Rheumatic disorder 38.71 11.89 80 810169 1463 49793412
Graft versus host disease in gastrointestinal tract 38.65 11.89 115 810134 2666 49792209
Product preparation error 38.65 11.89 11 810238 4361 49790514
Abortion incomplete 38.61 11.89 3 810246 3123 49791752
Oligohydramnios 38.58 11.89 22 810227 5728 49789147
Hypernatraemia 38.53 11.89 27 810222 6294 49788581
Posterior reversible encephalopathy syndrome 38.52 11.89 387 809862 14541 49780334
End stage renal disease 38.42 11.89 22 810227 5715 49789160
Peritoneal tuberculosis 38.29 11.89 43 810206 443 49794432
Glaucoma 38.26 11.89 402 809847 15284 49779591
Blood prolactin increased 38.20 11.89 3 810246 3096 49791779
Subdural haematoma 38.18 11.89 95 810154 12852 49782023
Mitral valve incompetence 38.16 11.89 147 810102 17324 49777551
Ovarian neoplasm 38.15 11.89 57 810192 795 49794080
Ventricular septal defect 37.95 11.89 9 810240 4032 49790843
Acute coronary syndrome 37.91 11.89 57 810192 9317 49785558
Thyroid neoplasm 37.84 11.89 133 810116 3374 49791501
Atrial flutter 37.70 11.89 51 810198 8712 49786163
Cardiomegaly 37.57 11.89 130 810119 15815 49779060
Faecaloma 37.54 11.89 35 810214 7073 49787802
Skin plaque 37.33 11.89 200 810049 6128 49788747
Throat tightness 37.30 11.89 189 810060 20658 49774217
Nausea 37.30 11.89 10395 799854 695003 49099872
Taste disorder 37.30 11.89 47 810202 8277 49786598
Tenderness 37.26 11.89 458 809791 18107 49776768
Human antichimeric antibody positive 37.12 11.89 77 810172 1412 49793463
Myelitis 37.05 11.89 69 810180 1165 49793710
Hypoaesthesia 37.04 11.89 1662 808587 125595 49669280
Foetal growth restriction 36.97 11.89 31 810218 6596 49788279
Coordination abnormal 36.93 11.89 81 810168 11453 49783422
Ischaemic stroke 36.92 11.89 131 810118 15817 49779058
Extranodal marginal zone B-cell lymphoma (MALT type) 36.83 11.89 41 810208 418 49794457
Bone swelling 36.76 11.89 68 810181 1142 49793733
Coagulopathy 36.66 11.89 155 810094 17789 49777086
Bronchospasm 36.44 11.89 119 810130 14735 49780140
Cold sweat 36.39 11.89 72 810177 10572 49784303
Ear pain 36.36 11.89 646 809603 27637 49767238
Complications of bone marrow transplant 36.32 11.89 41 810208 425 49794450
Hepatic failure 36.19 11.89 336 809913 31947 49762928
Systemic lupus erythematosus rash 36.09 11.89 84 810165 1671 49793204
Bronchial carcinoma 36.08 11.89 48 810201 597 49794278
Application site pruritus 36.04 11.89 8 810241 3751 49791124
Unintended pregnancy 36.04 11.89 17 810232 4929 49789946
Pruritus 36.02 11.89 3982 806267 279586 49515289
Hypertension 35.89 11.89 2902 807347 208301 49586574
Cutaneous T-cell lymphoma 35.87 11.89 69 810180 1195 49793680
Joint space narrowing 35.71 11.89 30 810219 208 49794667
Duodenal ulcer perforation 35.67 11.89 970 809279 44641 49750234
Hepatic enzyme abnormal 35.54 11.89 163 810086 4686 49790189
Osteoporotic fracture 35.44 11.89 121 810128 3024 49791851
Synostosis 35.43 11.89 18 810231 43 49794832
Alveolitis 35.42 11.89 105 810144 2429 49792446
Haematuria 35.40 11.89 252 809997 25361 49769514
Ileus 35.29 11.89 102 810147 13127 49781748
Drug screen positive 35.24 11.89 6 810243 3396 49791479
Left ventricular dysfunction 35.12 11.89 72 810177 10434 49784441
Rhinitis allergic 35.11 11.89 38 810211 7162 49787713
Electrocardiogram abnormal 35.06 11.89 42 810207 7563 49787312
Oxygen consumption increased 34.99 11.89 7 810242 3529 49791346
White blood cell count increased 34.93 11.89 471 809778 41769 49753106
Labelled drug-drug interaction medication error 34.86 11.89 72 810177 10405 49784470
Product residue present 34.84 11.89 8 810241 3664 49791211
Accidental exposure to product 34.79 11.89 221 810028 22836 49772039
Macular degeneration 34.79 11.89 116 810133 14272 49780603
Vaginal haemorrhage 34.69 11.89 240 810009 24311 49770564
Increased appetite 34.63 11.89 50 810199 8311 49786564
Iritis 34.62 11.89 104 810145 2424 49792451
Palmoplantar pustulosis 34.61 11.89 38 810211 381 49794494
Diffuse large B-cell lymphoma stage IV 34.49 11.89 31 810218 238 49794637
Activated partial thromboplastin time prolonged 34.43 11.89 31 810218 6371 49788504
Synovial disorder 34.43 11.89 56 810193 844 49794031
Faeces discoloured 34.37 11.89 137 810112 15987 49778888
Seronegative arthritis 34.31 11.89 91 810158 1970 49792905
Mycobacterium chelonae infection 34.28 11.89 39 810210 408 49794467
Tuberculous pleurisy 34.22 11.89 37 810212 364 49794511
Oliguria 34.16 11.89 49 810200 8167 49786708
Pharyngitis streptococcal 34.16 11.89 250 809999 8558 49786317
Ketoacidosis 34.06 11.89 10 810239 3885 49790990
Erythema 34.00 11.89 1957 808292 144457 49650418
Haemorrhoids 33.94 11.89 173 810076 18880 49775995
Aphasia 33.94 11.89 292 809957 28202 49766673
Drug specific antibody 33.92 11.89 84 810165 1741 49793134
Breast cancer stage III 33.86 11.89 122 810127 3134 49791741
Sacroiliitis 33.85 11.89 105 810144 2492 49792383
Leukaemia recurrent 33.82 11.89 67 810182 1187 49793688
Screaming 33.77 11.89 4 810245 2974 49791901
Long QT syndrome 33.61 11.89 4 810245 2963 49791912
Blood pressure inadequately controlled 33.57 11.89 14 810235 4366 49790509
Secretion discharge 33.56 11.89 270 809979 9521 49785354
C-reactive protein decreased 33.52 11.89 52 810197 751 49794124
Mucosal toxicity 33.42 11.89 33 810216 289 49794586
Hypoxic-ischaemic encephalopathy 33.35 11.89 10 810239 3832 49791043
Colon cancer 33.32 11.89 246 810003 8445 49786430
Eye irritation 33.23 11.89 151 810098 16989 49777886
Glomerular filtration rate decreased 33.20 11.89 87 810162 11565 49783310
Polyuria 33.18 11.89 39 810210 7082 49787793
Ankle arthroplasty 33.14 11.89 63 810186 1081 49793794
Choking 33.10 11.89 53 810196 8445 49786430
Visual acuity reduced 33.03 11.89 188 810061 19951 49774924
Ulcerative keratitis 32.92 11.89 97 810152 2236 49792639
Squamous cell carcinoma of lung 32.90 11.89 51 810198 736 49794139
Angina pectoris 32.72 11.89 265 809984 25923 49768952
Haemodialysis 32.71 11.89 52 810197 8310 49786565
Small intestinal obstruction 32.70 11.89 139 810110 15929 49778946
Pain in jaw 32.69 11.89 426 809823 38002 49756873
Skin lesion 32.44 11.89 605 809644 26122 49768753
Tonsillar ulcer 32.41 11.89 31 810218 260 49794615
Urine leukocyte esterase positive 32.38 11.89 4 810245 2879 49791996
Headache 32.36 11.89 7400 802849 499135 49295740
Pulmonary arterial pressure increased 32.36 11.89 7 810242 3341 49791534
Bundle branch block right 32.28 11.89 17 810232 4628 49790247
Therapy change 32.28 11.89 22 810227 5203 49789672
Blood glucose fluctuation 32.19 11.89 13 810236 4133 49790742
Ataxia 32.08 11.89 113 810136 13673 49781202
Incontinence 32.07 11.89 70 810179 9915 49784960
Vascular device infection 32.05 11.89 15 810234 4369 49790506
Failure to thrive 31.63 11.89 33 810216 6325 49788550
Pulmonary sarcoidosis 31.62 11.89 53 810196 820 49794055
Apnoea 31.56 11.89 39 810210 6927 49787948
Sudden death 31.45 11.89 60 810189 8931 49785944
Euglycaemic diabetic ketoacidosis 31.44 11.89 4 810245 2815 49792060
Renal disorder 31.38 11.89 285 809964 27220 49767655
Disability assessment scale score increased 31.35 11.89 96 810153 2262 49792613
Joint laxity 31.30 11.89 97 810152 2301 49792574
Aspiration bone marrow abnormal 31.26 11.89 15 810234 30 49794845
Blood pressure systolic abnormal 31.20 11.89 221 810028 7485 49787390
Hepatitis B 31.19 11.89 124 810125 3342 49791533
Product label confusion 31.05 11.89 40 810209 481 49794394
Application site pain 31.00 11.89 11 810238 3787 49791088
Arachnoiditis 30.97 11.89 30 810219 256 49794619
Viral upper respiratory tract infection 30.92 11.89 205 810044 6791 49788084
Drooling 30.88 11.89 8 810241 3376 49791499
Rheumatic fever 30.84 11.89 409 809840 16458 49778417
Arthritis infective 30.83 11.89 173 810076 5396 49789479
Brain natriuretic peptide increased 30.83 11.89 17 810232 4510 49790365
Small for dates baby 30.65 11.89 9 810240 3496 49791379
Carpal tunnel syndrome 30.62 11.89 409 809840 16484 49778391
Arteriosclerosis 30.52 11.89 62 810187 9015 49785860
Bronchitis 30.45 11.89 1996 808253 102163 49692712
Abortion induced 30.43 11.89 65 810184 9279 49785596
Extrapulmonary tuberculosis 30.42 11.89 31 810218 283 49794592
Skin reaction 30.39 11.89 301 809948 11267 49783608
Acute pulmonary histoplasmosis 30.35 11.89 22 810227 119 49794756
Skin exfoliation 30.31 11.89 368 809881 33244 49761631
Bundle branch block left 30.25 11.89 33 810216 6197 49788678
Cerebral toxoplasmosis 30.21 11.89 46 810203 653 49794222
Anaemia macrocytic 30.20 11.89 100 810149 2459 49792416
Tooth abscess 30.17 11.89 327 809922 12533 49782342
Epstein-Barr viraemia 30.17 11.89 52 810197 824 49794051
Product prescribing error 30.06 11.89 204 810045 20757 49774118
Colitis ischaemic 30.03 11.89 67 810182 9416 49785459
Feeling hot 29.98 11.89 444 809805 38758 49756117
Disease recurrence 29.98 11.89 470 809779 19611 49775264
Infective tenosynovitis 29.97 11.89 27 810222 208 49794667
Migraine 29.94 11.89 947 809302 74333 49720542
Aplasia pure red cell 29.93 11.89 15 810234 4200 49790675
Bunion operation 29.77 11.89 60 810189 1077 49793798
Cytomegalovirus chorioretinitis 29.76 11.89 71 810178 1436 49793439
Restless legs syndrome 29.67 11.89 142 810107 15755 49779120
Jaundice cholestatic 29.64 11.89 23 810226 5088 49789787
Myocarditis 29.62 11.89 51 810198 7896 49786979
Infusion site haemorrhage 29.61 11.89 6 810243 2998 49791877
Sciatica 29.51 11.89 494 809755 20888 49773987
Psychomotor retardation 29.48 11.89 9 810240 3409 49791466
Proteinuria 29.40 11.89 151 810098 16446 49778429
Hyperventilation 29.32 11.89 26 810223 5383 49789492
Lung transplant 29.22 11.89 5 810244 2820 49792055
Limb operation 29.20 11.89 119 810130 3245 49791630
Haemolytic anaemia 29.14 11.89 66 810183 9226 49785649
Cutaneous leishmaniasis 29.08 11.89 18 810231 71 49794804
Epstein-Barr virus antigen positive 28.86 11.89 14 810235 29 49794846
Cataract 28.68 11.89 975 809274 46325 49748550
Infusion site extravasation 28.62 11.89 42 810207 6934 49787941
Embolic stroke 28.60 11.89 10 810239 3474 49791401
Hallucinations, mixed 28.54 11.89 15 810234 4088 49790787
Angioimmunoblastic T-cell lymphoma stage IV 28.35 11.89 9 810240 0 49794875
Coma scale abnormal 28.27 11.89 21 810228 4750 49790125
Hyperlactacidaemia 28.27 11.89 3 810246 2430 49792445
Synovial rupture 28.22 11.89 23 810226 152 49794723
Tongue neoplasm malignant stage unspecified 28.18 11.89 47 810202 724 49794151
Device occlusion 28.05 11.89 33 810216 5990 49788885
Gastric disorder 28.03 11.89 645 809604 28903 49765972
Ventricular arrhythmia 28.03 11.89 9 810240 3300 49791575
Respiratory tract congestion 27.94 11.89 349 809900 13850 49781025
Antibody test positive 27.89 11.89 91 810158 2220 49792655
Blood bicarbonate decreased 27.80 11.89 5 810244 2720 49792155
Blood thyroid stimulating hormone increased 27.71 11.89 34 810215 6058 49788817
Hepatitis 27.53 11.89 679 809570 30774 49764101
Eyelid oedema 27.49 11.89 70 810179 9396 49785479
COVID-19 27.46 11.89 554 809695 46108 49748767
Neoplasm recurrence 27.45 11.89 92 810157 2277 49792598
Azotaemia 27.37 11.89 15 810234 3993 49790882
International normalised ratio abnormal 27.36 11.89 6 810243 2837 49792038
Diplopia 27.35 11.89 188 810061 19072 49775803
Ophthalmic herpes zoster 27.31 11.89 74 810175 1623 49793252
Haemorrhagic stroke 27.31 11.89 26 810223 5202 49789673
Catheter site pain 27.30 11.89 13 810236 3749 49791126
Blood pressure diastolic abnormal 27.28 11.89 249 810000 9112 49785763
Cerebral infarction 27.27 11.89 218 810031 21386 49773489
Metastases to central nervous system 27.25 11.89 91 810158 11191 49783684
Bronchiectasis 27.22 11.89 268 809981 10015 49784860
Amylase increased 27.22 11.89 28 810221 5402 49789473
Viral vasculitis 27.18 11.89 15 810234 45 49794830
Lacrimation increased 27.13 11.89 160 810089 16832 49778043
Mycobacterial infection 27.11 11.89 71 810178 1525 49793350
Cryptococcosis 27.10 11.89 50 810199 838 49794037
Respiration abnormal 27.09 11.89 25 810224 5077 49789798
Dysphoria 27.04 11.89 22 810227 4752 49790123
Food allergy 27.00 11.89 56 810193 8081 49786794
Hypertonia 26.94 11.89 15 810234 3958 49790917
Episcleritis 26.87 11.89 47 810202 754 49794121
Immune thrombocytopenia 26.72 11.89 66 810183 8951 49785924
Dislocation of vertebra 26.63 11.89 109 810140 2978 49791897
Weight decreased 26.62 11.89 3118 807131 218127 49576748
Heavy menstrual bleeding 26.60 11.89 143 810106 15394 49779481
Ovarian cancer 26.58 11.89 157 810092 4992 49789883
Rales 26.56 11.89 77 810172 9901 49784974
Hypokinesia 26.55 11.89 103 810146 12114 49782761
Pneumonia viral 26.52 11.89 194 810055 6640 49788235
Coronary arterial stent insertion 26.51 11.89 5 810244 2629 49792246
Traumatic lung injury 26.44 11.89 66 810183 1375 49793500
Squamous cell carcinoma 26.30 11.89 213 810036 7526 49787349
Gait disturbance 26.26 11.89 2765 807484 147240 49647635
Red cell distribution width decreased 26.22 11.89 56 810193 1049 49793826
Joint warmth 26.19 11.89 64 810185 1315 49793560
Blood phosphorus decreased 26.14 11.89 14 810235 3775 49791100
Disturbance in social behaviour 26.11 11.89 7 810242 2887 49791988
Asphyxia 26.07 11.89 29 810220 5398 49789477
Antinuclear antibody positive 26.06 11.89 181 810068 6091 49788784
Eosinophil count increased 25.87 11.89 65 810184 8765 49786110
Cancer pain 25.85 11.89 5 810244 2582 49792293
Mean platelet volume decreased 25.83 11.89 71 810178 1571 49793304
Myocardial ischaemia 25.83 11.89 97 810152 11516 49783359
Multiple sclerosis 25.77 11.89 207 810042 20286 49774589
Exercise tolerance decreased 25.74 11.89 24 810225 4850 49790025
Coccidioidomycosis 25.63 11.89 48 810201 814 49794061
Joint lock 25.55 11.89 82 810167 1983 49792892
Laryngeal disorder 25.54 11.89 49 810200 847 49794028
Device leakage 25.50 11.89 34 810215 5844 49789031
Clostridium difficile infection 25.50 11.89 272 809977 25167 49769708
Spinal pain 25.48 11.89 275 809974 10528 49784347
Post-traumatic stress disorder 25.42 11.89 19 810230 4284 49790591
Enterovirus test positive 25.39 11.89 20 810229 125 49794750
Therapeutic response unexpected 25.34 11.89 150 810099 15765 49779110
Isosporiasis 25.33 11.89 13 810236 32 49794843
Back pain 25.31 11.89 3110 807139 216920 49577955
Tooth infection 25.30 11.89 341 809908 13771 49781104
Insurance issue 25.30 11.89 5 810244 2543 49792332
Angioimmunoblastic T-cell lymphoma 25.23 11.89 17 810232 80 49794795
Anaplastic large-cell lymphoma 25.23 11.89 17 810232 80 49794795
Carcinoma in situ of skin 25.21 11.89 24 810225 200 49794675
Blood thyroid stimulating hormone decreased 25.20 11.89 18 810231 4154 49790721
Urine abnormality 25.16 11.89 38 810211 6200 49788675
Post procedural haemorrhage 25.01 11.89 49 810200 7221 49787654
Pulse absent 24.99 11.89 24 810225 4782 49790093
Catheterisation cardiac 24.97 11.89 17 810232 4023 49790852
Varicella 24.89 11.89 72 810177 1642 49793233
Lower respiratory tract infection viral 24.84 11.89 41 810208 626 49794249
Performance status decreased 24.83 11.89 10 810239 3185 49791690
Peripheral coldness 24.80 11.89 83 810166 10200 49784675
Diffuse large B-cell lymphoma stage III 24.79 11.89 13 810236 34 49794841
Tendon disorder 24.77 11.89 158 810091 5164 49789711
Cartilage atrophy 24.63 11.89 21 810228 149 49794726
Bone tuberculosis 24.59 11.89 23 810226 187 49794688
Hypersomnia 24.56 11.89 144 810105 15170 49779705
Blood lactic acid increased 24.54 11.89 32 810217 5553 49789322
Craniosynostosis 24.52 11.89 21 810228 150 49794725
Swollen joint count increased 24.49 11.89 354 809895 14519 49780356
Tendon rupture 24.49 11.89 197 810052 6947 49787928
Therapeutic response shortened 24.38 11.89 202 810047 7187 49787688
Toxic skin eruption 24.36 11.89 95 810154 11156 49783719
Granuloma 24.35 11.89 147 810102 4711 49790164
Feeling jittery 24.31 11.89 94 810155 11066 49783809
Hypophagia 24.09 11.89 306 809943 27422 49767453
Intervertebral disc space narrowing 24 11.89 49 810200 888 49793987
Growth failure 23.98 11.89 28 810221 302 49794573
Breast cancer female 23.94 11.89 190 810059 6672 49788203
Meningoencephalitis herpetic 23.92 11.89 53 810196 1019 49793856
Galactorrhoea 23.91 11.89 15 810234 3708 49791167
Hepatitis B virus test positive 23.86 11.89 23 810226 195 49794680
Skin papilloma 23.83 11.89 132 810117 4097 49790778
Nail disorder 23.77 11.89 249 810000 9459 49785416
Emotional disorder 23.71 11.89 103 810146 11733 49783142
Ganglioneuroma 23.61 11.89 19 810230 123 49794752
Haemodynamic instability 23.56 11.89 59 810190 7965 49786910
Pleuropericarditis 23.56 11.89 24 810225 219 49794656
Hypovolaemic shock 23.55 11.89 29 810220 5159 49789716
Rheumatoid factor 23.54 11.89 15 810234 63 49794812
Hepatosplenomegaly 23.51 11.89 86 810163 2226 49792649
Extra dose administered 23.44 11.89 28 810221 5048 49789827
Rectal cancer 23.43 11.89 71 810178 1663 49793212
Wheelchair user 23.39 11.89 148 810101 4824 49790051
Ankle operation 23.36 11.89 57 810192 1170 49793705
Anaphylactic shock 23.36 11.89 208 810041 19947 49774928
Biliary dyskinesia 23.32 11.89 6 810243 2544 49792331
Blood chloride decreased 23.30 11.89 27 810222 4934 49789941
Anaemia megaloblastic 23.27 11.89 27 810222 289 49794586
Paradoxical psoriasis 23.26 11.89 19 810230 126 49794749
Rash erythematous 23.23 11.89 405 809844 34447 49760428
Dermatitis psoriasiform 23.19 11.89 70 810179 1636 49793239
Mycobacterium avium complex infection 23.16 11.89 91 810158 2439 49792436
Toe operation 23.15 11.89 40 810209 635 49794240
Disease susceptibility 23.14 11.89 22 810227 183 49794692
Low turnover osteopathy 23.13 11.89 18 810231 3976 49790899
Blood albumin decreased 23.12 11.89 121 810128 13115 49781760
Human rhinovirus test positive 23.02 11.89 20 810229 146 49794729
Colitis microscopic 23.01 11.89 181 810068 6339 49788536
Inhibitory drug interaction 22.99 11.89 4 810245 2229 49792646
Middle lobe syndrome 22.99 11.89 12 810237 31 49794844
Injection site inflammation 22.94 11.89 107 810142 3098 49791777
Oropharyngeal pain 22.93 11.89 1492 808757 76309 49718566
Plasma cell myeloma recurrent 22.92 11.89 7 810242 2651 49792224
Myelodysplastic syndrome 22.91 11.89 355 809894 14777 49780098
Tubal rupture 22.76 11.89 9 810240 8 49794867
Rash macular 22.76 11.89 198 810051 19079 49775796
Cardiac murmur 22.75 11.89 92 810157 10692 49784183
Decubitus ulcer 22.72 11.89 76 810173 9342 49785533
Infected dermal cyst 22.70 11.89 32 810217 422 49794453
Application site rash 22.63 11.89 5 810244 2352 49792523
Growth retardation 22.61 11.89 52 810197 1026 49793849
Drug ineffective for unapproved indication 22.56 11.89 472 809777 20809 49774066
Abdominal pain lower 22.46 11.89 231 810018 21525 49773350
Sensory disturbance 22.46 11.89 105 810144 11724 49783151
Malignant peritoneal neoplasm 22.45 11.89 39 810210 622 49794253
Gastritis 22.40 11.89 382 809867 32601 49762274
Stress cardiomyopathy 22.39 11.89 59 810190 7828 49787047
Blood triglycerides increased 22.32 11.89 99 810150 11213 49783662
Urine ketone body present 22.30 11.89 5 810244 2328 49792547
Hyperthermia 22.28 11.89 57 810192 7639 49787236
Infection reactivation 22.25 11.89 49 810200 938 49793937
General physical health deterioration 22.23 11.89 1970 808279 140464 49654411
Eye movement disorder 22.15 11.89 24 810225 4521 49790354
Myelitis transverse 22.15 11.89 50 810199 974 49793901
Urticarial vasculitis 22.11 11.89 36 810213 543 49794332
Haemolysis 22.06 11.89 39 810210 5977 49788898
Osteophyte fracture 22.05 11.89 7 810242 0 49794875
Mood swings 22.03 11.89 157 810092 15797 49779078
Cutaneous tuberculosis 21.94 11.89 19 810230 138 49794737
Alcohol use 21.85 11.89 3 810246 1992 49792883
Abdominal wall haematoma 21.84 11.89 8 810241 2700 49792175
Cystitis haemorrhagic 21.84 11.89 117 810132 3585 49791290
Thirst 21.75 11.89 92 810157 10558 49784317
Cardiac failure acute 21.72 11.89 64 810185 8186 49786689
Cardioactive drug level increased 21.69 11.89 3 810246 1981 49792894
Nodular melanoma 21.63 11.89 13 810236 48 49794827
Pancreatitis 21.61 11.89 518 809731 42096 49752779
Red blood cell sedimentation rate 21.61 11.89 114 810135 3472 49791403
Epstein-Barr virus test positive 21.59 11.89 35 810214 526 49794349
Ocular sarcoidosis 21.52 11.89 12 810237 37 49794838
Sexual dysfunction 21.51 11.89 13 810236 3279 49791596
Catheter site haemorrhage 21.51 11.89 9 810240 2801 49792074
Major depression 21.50 11.89 49 810200 6835 49788040
Clostridium difficile colitis 21.50 11.89 181 810068 17561 49777314
Injection site irritation 21.41 11.89 131 810118 4219 49790656
Dermatitis acneiform 21.40 11.89 20 810229 4037 49790838
Walking aid user 21.30 11.89 176 810073 6257 49788618
Pruritus allergic 21.29 11.89 52 810197 1068 49793807
Cardiomyopathy 21.22 11.89 154 810095 15432 49779443
Feeling cold 21.15 11.89 205 810044 19326 49775549
Incorrect dosage administered 21.15 11.89 68 810181 1646 49793229
Refusal of treatment by patient 21.14 11.89 30 810219 5023 49789852
Anal abscess 21.14 11.89 118 810131 3673 49791202
Electrocardiogram T wave inversion 21.14 11.89 13 810236 3248 49791627
Foot fracture 21.10 11.89 445 809804 19646 49775229
Exostosis 21.07 11.89 282 809967 11371 49783504
Respiratory disorder 21.01 11.89 651 809598 30536 49764339
Multiple drug therapy 21.01 11.89 3 810246 1934 49792941
Peptic ulcer haemorrhage 20.88 11.89 49 810200 980 49793895
Tearfulness 20.87 11.89 17 810232 3670 49791205
Self-injurious ideation 20.86 11.89 5 810244 2224 49792651
Chronic recurrent multifocal osteomyelitis 20.85 11.89 12 810237 40 49794835
Post procedural infection 20.82 11.89 199 810050 7377 49787498
Amenorrhoea 20.79 11.89 68 810181 8416 49786459
Initial insomnia 20.78 11.89 31 810218 5084 49789791
Subdural haemorrhage 20.73 11.89 9 810240 2740 49792135
Obsessive-compulsive disorder 20.72 11.89 14 810235 3326 49791549
Diastolic dysfunction 20.71 11.89 33 810216 5269 49789606
Dermatitis contact 20.70 11.89 70 810179 8576 49786299
Overlap syndrome 20.67 11.89 37 810212 605 49794270
Prosthesis user 20.60 11.89 14 810235 67 49794808
Eye pruritus 20.56 11.89 117 810132 12417 49782458
Mesenteritis 20.55 11.89 18 810231 133 49794742
Lyme disease 20.54 11.89 88 810161 2455 49792420
Plasmablastic lymphoma 20.53 11.89 20 810229 172 49794703
Blood cholesterol increased 20.49 11.89 1081 809168 54134 49740741
Salivary gland cancer 20.45 11.89 19 810230 153 49794722
Borrelia infection 20.44 11.89 17 810232 116 49794759
Acquired claw toe 20.44 11.89 20 810229 173 49794702
Therapeutic product effect delayed 20.41 11.89 75 810174 1946 49792929
Pyrexia 20.38 11.89 5598 804651 374605 49420270
Hyperuricaemia 20.37 11.89 27 810222 4653 49790222
Tibia fracture 20.31 11.89 132 810117 4343 49790532
Eczema 20.30 11.89 249 810000 22453 49772422
Sinus node dysfunction 20.28 11.89 20 810229 3935 49790940
Logorrhoea 20.26 11.89 6 810243 2318 49792557
Injection site haematoma 20.17 11.89 166 810083 5894 49788981
Mucormycosis 20.11 11.89 86 810163 2397 49792478
Pulmonary nocardiosis 20.08 11.89 19 810230 157 49794718
Catheter site discharge 20.01 11.89 3 810246 1865 49793010
Ammonia increased 20.01 11.89 23 810226 4218 49790657
Mycotic allergy 20.00 11.89 42 810207 777 49794098
Peripheral T-cell lymphoma unspecified 19.99 11.89 19 810230 158 49794717
Central nervous system lesion 19.99 11.89 81 810168 9408 49785467
Seasonal allergy 19.98 11.89 145 810104 14531 49780344
Meningitis coccidioides 19.93 11.89 10 810239 23 49794852
Hypergammaglobulinaemia benign monoclonal 19.93 11.89 37 810212 623 49794252
Snoring 19.92 11.89 15 810234 3369 49791506
Inadequate analgesia 19.89 11.89 8 810241 2550 49792325
Incoherent 19.89 11.89 23 810226 4207 49790668
Adverse event 19.87 11.89 874 809375 42889 49751986
Pelvic pain 19.87 11.89 102 810147 11111 49783764
Knee deformity 19.87 11.89 48 810201 979 49793896
Poor venous access 19.85 11.89 253 809996 10087 49784788
Metatarsalgia 19.84 11.89 23 810226 246 49794629
Leishmaniasis 19.81 11.89 13 810236 58 49794817
Malignant melanoma in situ 19.79 11.89 42 810207 783 49794092
Social avoidant behaviour 19.79 11.89 10 810239 2787 49792088
Infiltration anaesthesia 19.75 11.89 18 810231 141 49794734
Empyema 19.71 11.89 70 810179 1785 49793090
Alcohol interaction 19.70 11.89 5 810244 2139 49792736
Legionella infection 19.69 11.89 29 810220 399 49794476
Bicytopenia 19.68 11.89 72 810177 1864 49793011
Electrocardiogram ST segment elevation 19.68 11.89 16 810233 3457 49791418
Eructation 19.66 11.89 54 810195 7067 49787808
Varicella zoster pneumonia 19.65 11.89 10 810239 24 49794851
Procedural pain 19.65 11.89 135 810114 13697 49781178
Nystagmus 19.55 11.89 37 810212 5524 49789351
Blood sodium increased 19.53 11.89 7 810242 2395 49792480
Diffuse large B-cell lymphoma stage II 19.45 11.89 12 810237 47 49794828
Cervix carcinoma stage 0 19.44 11.89 25 810224 300 49794575
Acute graft versus host disease in liver 19.44 11.89 35 810214 575 49794300
Catheter site infection 19.41 11.89 24 810225 4262 49790613
Acute pulmonary oedema 19.40 11.89 56 810193 7211 49787664
Oropharyngeal cancer 19.38 11.89 10 810239 25 49794850
Nocturia 19.37 11.89 50 810199 6680 49788195
Haematochezia 19.35 11.89 488 809761 39394 49755481
Inflammatory pain 19.34 11.89 40 810209 732 49794143
Abscess sweat gland 19.32 11.89 8 810241 9 49794866
Pemphigoid 19.31 11.89 41 810208 5866 49789009
Double stranded DNA antibody positive 19.29 11.89 24 810225 278 49794597
Cytomegalovirus infection 19.24 11.89 399 809850 17563 49777312
Bone density decreased 19.20 11.89 266 809983 10809 49784066
Medial tibial stress syndrome 19.14 11.89 15 810234 93 49794782
Chest X-ray abnormal 19.12 11.89 117 810132 3768 49791107
Extrasystoles 19.12 11.89 28 810221 4627 49790248
Accidental overdose 19.11 11.89 210 810039 19323 49775552
Keratopathy 19.11 11.89 30 810219 438 49794437
Electrocardiogram ST segment depression 19.10 11.89 9 810240 2611 49792264
Micturition urgency 19.05 11.89 68 810181 8196 49786679
Malignant neoplasm of conjunctiva 19.04 11.89 11 810238 37 49794838
Hypoacusis 19.02 11.89 225 810024 20422 49774453
Laryngitis fungal 18.97 11.89 17 810232 130 49794745
Decreased immune responsiveness 18.97 11.89 118 810131 3823 49791052
Hair follicle tumour benign 18.94 11.89 27 810222 360 49794515
Back injury 18.92 11.89 185 810064 6900 49787975
Arthritis viral 18.90 11.89 6 810243 0 49794875
Ectrodactyly 18.90 11.89 6 810243 0 49794875
Oropharyngeal discolouration 18.90 11.89 6 810243 0 49794875
Subdural abscess 18.85 11.89 10 810239 27 49794848
Oesophagitis 18.82 11.89 131 810118 13252 49781623
Purpura 18.81 11.89 88 810161 9823 49785052
Chondropathy 18.79 11.89 75 810174 2025 49792850
Rheumatoid vasculitis 18.79 11.89 25 810224 311 49794564
Hypoventilation 18.78 11.89 21 810228 3900 49790975
Laboratory test abnormal 18.75 11.89 260 809989 22948 49771927
Rib fracture 18.67 11.89 207 810042 19014 49775861
Hepatic function abnormal 18.64 11.89 390 809859 32291 49762584
Diverticular perforation 18.60 11.89 100 810149 3068 49791807
Malnutrition 18.60 11.89 129 810120 13060 49781815
Visual impairment 18.59 11.89 898 809351 67377 49727498
Prescribed overdose 18.58 11.89 147 810102 14453 49780422
Blood pH decreased 18.57 11.89 8 810241 2447 49792428
Road traffic accident 18.55 11.89 276 809973 24076 49770799
Laryngospasm 18.44 11.89 10 810239 2678 49792197
Wernicke's encephalopathy 18.44 11.89 9 810240 19 49794856
Angina unstable 18.41 11.89 51 810198 6655 49788220
Intervertebral disc protrusion 18.38 11.89 442 809807 19951 49774924
Bedridden 18.33 11.89 230 810019 9137 49785738
Psychiatric symptom 18.28 11.89 28 810221 4542 49790333
Crying 18.23 11.89 224 810025 20192 49774683
Tongue neoplasm 18.23 11.89 11 810238 41 49794834
Alanine aminotransferase increased 18.22 11.89 1194 809055 87165 49707710
Angle closure glaucoma 18.20 11.89 5 810244 2029 49792846
Implant site pain 18.19 11.89 6 810243 2163 49792712
Torus fracture 18.19 11.89 16 810233 119 49794756
Mass excision 18.19 11.89 22 810227 247 49794628
Bradyarrhythmia 18.17 11.89 4 810245 1886 49792989
Cardiac pacemaker insertion 18.13 11.89 19 810230 3634 49791241
Mononeuritis 18.12 11.89 10 810239 30 49794845
Incorrect dose administered 18.07 11.89 614 809635 47800 49747075
Dyspnoea at rest 18.06 11.89 19 810230 3628 49791247
Mucosal disorder 18.03 11.89 69 810180 1826 49793049
Cholestatic liver injury 18.02 11.89 5 810244 2016 49792859
Perineal infection 17.99 11.89 16 810233 121 49794754
Glioma 17.95 11.89 23 810226 275 49794600
Chemotherapeutic drug level above therapeutic 17.89 11.89 10 810239 31 49794844
Multiple-drug resistance 17.88 11.89 16 810233 3298 49791577
Tender joint count increased 17.84 11.89 11 810238 43 49794832
Interferon gamma release assay positive 17.84 11.89 11 810238 43 49794832
Cervical dysplasia 17.80 11.89 90 810159 2695 49792180
Blood pressure increased 17.73 11.89 1863 808386 131269 49663606
Bloody discharge 17.71 11.89 50 810199 1124 49793751
Neck mass 17.68 11.89 103 810146 3258 49791617
Thrombosis in device 17.67 11.89 11 810238 2730 49792145
Dermatomyositis 17.62 11.89 75 810174 2086 49792789
Petit mal epilepsy 17.60 11.89 16 810233 3273 49791602
Electrocardiogram T wave abnormal 17.60 11.89 7 810242 2246 49792629
Sinus arrest 17.58 11.89 3 810246 1695 49793180
Hypermobility syndrome 17.54 11.89 38 810211 719 49794156
Squamous cell carcinoma of the cervix 17.54 11.89 22 810227 257 49794618
Acute myeloid leukaemia 17.53 11.89 339 809910 14735 49780140
Squamous cell carcinoma of the oral cavity 17.53 11.89 23 810226 282 49794593
Congestive hepatopathy 17.52 11.89 9 810240 2485 49792390
Invasive ductal breast carcinoma 17.51 11.89 158 810091 5763 49789112
Granulomatosis with polyangiitis 17.51 11.89 66 810183 1734 49793141
Apathy 17.47 11.89 62 810187 7486 49787389
Lung cancer metastatic 17.46 11.89 78 810171 2217 49792658
Portal tract inflammation 17.45 11.89 10 810239 33 49794842
Quadriplegia 17.45 11.89 64 810185 1659 49793216
Blood lactate dehydrogenase increased 17.33 11.89 215 810034 19347 49775528
Lichen myxoedematosus 17.31 11.89 9 810240 23 49794852
Medical device discomfort 17.28 11.89 3 810246 1674 49793201
Meningitis tuberculous 17.27 11.89 31 810218 508 49794367
Engraftment syndrome 17.27 11.89 24 810225 312 49794563
JC virus infection 17.20 11.89 66 810183 1749 49793126
Pyoderma gangrenosum 17.06 11.89 90 810159 2741 49792134
Ocular toxicity 17.02 11.89 31 810218 514 49794361
Fear-related avoidance of activities 17.01 11.89 15 810234 112 49794763
Body height decreased 16.96 11.89 79 810170 8829 49786046
Hypertensive crisis 16.94 11.89 132 810117 13022 49781853
Osteochondrosis 16.91 11.89 47 810202 1047 49793828
Breast abscess 16.90 11.89 55 810194 1340 49793535
Tumour marker increased 16.87 11.89 22 810227 3818 49791057
Ocular hyperaemia 16.87 11.89 226 810023 20066 49774809
Pyomyositis 16.87 11.89 25 810224 346 49794529
Atelectasis 16.87 11.89 199 810050 18071 49776804
Folate deficiency 16.84 11.89 69 810180 1886 49792989
Vitamin D deficiency 16.84 11.89 110 810139 11292 49783583
Nasal polyps 16.81 11.89 10 810239 2544 49792331
Malignant neoplasm of ampulla of Vater 16.79 11.89 9 810240 25 49794850
Lymphadenopathy 16.79 11.89 676 809573 32823 49762052
Device physical property issue 16.78 11.89 3 810246 1639 49793236
Respiratory rate decreased 16.78 11.89 15 810234 3093 49791782
Blood pressure diastolic decreased 16.76 11.89 369 809880 16412 49778463
Language disorder 16.76 11.89 4 810245 1784 49793091
Immunodeficiency 16.75 11.89 332 809917 14496 49780379
Herpes simplex 16.75 11.89 182 810067 6980 49787895
Stress at work 16.70 11.89 46 810203 1019 49793856
Small intestinal haemorrhage 16.70 11.89 5 810244 1918 49792957
Central nervous system lymphoma 16.70 11.89 54 810195 1311 49793564
Anaplastic thyroid cancer 16.67 11.89 8 810241 16 49794859
Disseminated sporotrichosis 16.67 11.89 8 810241 16 49794859
Injection site discolouration 16.67 11.89 178 810071 6796 49788079
Cyst 16.61 11.89 281 809968 11906 49782969
Transplant dysfunction 16.61 11.89 31 810218 4653 49790222
Root canal infection 16.57 11.89 20 810229 224 49794651
Concomitant disease progression 16.56 11.89 6 810243 2039 49792836
Body temperature increased 16.54 11.89 636 809613 30705 49764170
Hyperparathyroidism 16.54 11.89 9 810240 2405 49792470
Malabsorption 16.53 11.89 21 810228 3685 49791190
Osteomyelitis 16.52 11.89 472 809777 21881 49772994
Gallbladder necrosis 16.52 11.89 6 810243 3 49794872
Stenosis 16.52 11.89 49 810200 1134 49793741
Pharyngeal abscess 16.52 11.89 21 810228 249 49794626
Alcoholism 16.47 11.89 3 810246 1617 49793258
West Nile viral infection 16.46 11.89 25 810224 354 49794521
Obliterative bronchiolitis 16.44 11.89 66 810183 1787 49793088
Hepatitis cholestatic 16.43 11.89 47 810202 6070 49788805
Blood urine present 16.43 11.89 129 810120 12704 49782171
Application site irritation 16.40 11.89 3 810246 1612 49793263
Secondary immunodeficiency 16.39 11.89 49 810200 1139 49793736
Left ventricular hypertrophy 16.37 11.89 33 810216 4812 49790063
Morphoea 16.34 11.89 22 810227 277 49794598
Dermatitis atopic 16.33 11.89 20 810229 3566 49791309
Brachiocephalic artery stenosis 16.31 11.89 9 810240 27 49794848
Gout 16.27 11.89 112 810137 11358 49783517
Gastric cancer 16.21 11.89 93 810156 2925 49791950
Product taste abnormal 16.17 11.89 4 810245 1741 49793134
Economic problem 16.15 11.89 5 810244 1877 49792998
Lymphoedema 16.15 11.89 83 810166 9039 49785836
Q fever 16.13 11.89 12 810237 68 49794807
Communication disorder 16.13 11.89 8 810241 2253 49792622
Lip and/or oral cavity cancer 16.11 11.89 23 810226 307 49794568
Ecchymosis 16.11 11.89 96 810153 10073 49784802
Skin tightness 16.09 11.89 22 810227 3741 49791134
Libido decreased 16.07 11.89 9 810240 2367 49792508
Euphoric mood 16.07 11.89 25 810224 4030 49790845
Papulopustular rosacea 16.06 11.89 8 810241 18 49794857
Blood glucose abnormal 15.99 11.89 54 810195 6618 49788257
Oral mucosa erosion 15.99 11.89 45 810204 1010 49793865
Mixed liver injury 15.97 11.89 19 810230 3432 49791443
Drug eruption 15.97 11.89 493 809756 23113 49771762
Oral disorder 15.95 11.89 194 810055 7650 49787225
Protein total decreased 15.94 11.89 38 810211 5218 49789657
Chronic graft versus host disease oral 15.93 11.89 14 810235 104 49794771
Bone disorder 15.87 11.89 403 809846 18349 49776526
Post procedural inflammation 15.86 11.89 9 810240 29 49794846
Gastrointestinal inflammation 15.85 11.89 127 810122 4473 49790402
Superior sagittal sinus thrombosis 15.83 11.89 35 810214 672 49794203
Metastatic bronchial carcinoma 15.83 11.89 14 810235 105 49794770
Respiratory tract ulceration 15.75 11.89 5 810244 0 49794875
Exposed bone in jaw 15.74 11.89 13 810236 2787 49792088
Myopathy 15.71 11.89 84 810165 9055 49785820
Guttate psoriasis 15.70 11.89 24 810225 342 49794533
Appetite disorder 15.69 11.89 48 810201 6066 49788809
Dyspepsia 15.67 11.89 999 809250 73098 49721777
Premature rupture of membranes 15.64 11.89 31 810218 4549 49790326
Lung squamous cell carcinoma stage I 15.62 11.89 7 810242 11 49794864
Reactive gastropathy 15.59 11.89 25 810224 372 49794503
Idiopathic pneumonia syndrome 15.59 11.89 23 810226 317 49794558
Brain injury 15.58 11.89 47 810202 5967 49788908
Arteriosclerosis coronary artery 15.57 11.89 66 810183 7570 49787305
Infusion site infection 15.55 11.89 3 810246 1552 49793323
Hypoglycaemic coma 15.55 11.89 9 810240 2324 49792551
Blood pressure diastolic increased 15.54 11.89 185 810064 7258 49787617
Middle insomnia 15.53 11.89 94 810155 9827 49785048
Brain oedema 15.53 11.89 125 810124 12245 49782630
Leukodystrophy 15.50 11.89 8 810241 20 49794855
Eye pain 15.50 11.89 342 809907 28107 49766768
Diabetic retinopathy 15.49 11.89 8 810241 2202 49792673
Follicle centre lymphoma, follicular grade I, II, III 15.48 11.89 12 810237 73 49794802
Expired product administered 15.48 11.89 40 810209 5342 49789533
Dry eye 15.47 11.89 645 809604 31450 49763425
Pleural fibrosis 15.47 11.89 100 810149 3284 49791591
Haemoperitoneum 15.46 11.89 11 810238 2544 49792331
Multiple fractures 15.46 11.89 168 810081 6443 49788432
Duodenal ulcer 15.45 11.89 56 810193 6719 49788156
Large granular lymphocytosis 15.44 11.89 17 810232 171 49794704
Electroencephalogram abnormal 15.42 11.89 20 810229 3479 49791396
Subarachnoid haemorrhage 15.39 11.89 105 810144 10671 49784204
Bile duct cancer 15.38 11.89 32 810217 588 49794287
Vasculitis 15.38 11.89 312 809937 13679 49781196
Erythema induratum 15.38 11.89 16 810233 150 49794725
Lymphoplasmacytoid lymphoma/immunocytoma 15.35 11.89 6 810243 5 49794870
Nephrolithiasis 15.34 11.89 691 809558 34002 49760873
Decreased interest 15.31 11.89 15 810234 2961 49791914
Bipolar disorder 15.31 11.89 56 810193 6701 49788174
Ischaemic cardiomyopathy 15.29 11.89 9 810240 2303 49792572
Tonsil cancer 15.29 11.89 18 810231 196 49794679
Acute interstitial pneumonitis 15.28 11.89 32 810217 591 49794284
Pharyngeal ulceration 15.28 11.89 32 810217 591 49794284
Respiratory rate increased 15.25 11.89 113 810136 11272 49783603
Premature separation of placenta 15.25 11.89 4 810245 1674 49793201
Scleroderma renal crisis 15.22 11.89 21 810228 271 49794604
Enzyme level increased 15.18 11.89 22 810227 298 49794577
Anxiety disorder 15.18 11.89 22 810227 3651 49791224
International normalised ratio decreased 15.11 11.89 27 810222 4121 49790754
Colitis ulcerative 15.10 11.89 365 809884 16489 49778386
Injection site induration 15.09 11.89 203 810046 8194 49786681
Iris adhesions 15.08 11.89 22 810227 300 49794575
Device use issue 15.06 11.89 6 810243 1923 49792952
Perineal necrosis 15.04 11.89 14 810235 113 49794762
Pseudomonas test positive 15.01 11.89 33 810216 631 49794244
Hiatus hernia 15 11.89 205 810044 18139 49776736
Supraventricular extrasystoles 14.98 11.89 25 810224 3919 49790956
Subclavian artery occlusion 14.98 11.89 8 810241 22 49794853
Hydronephrosis 14.96 11.89 78 810171 8463 49786412
Anal incontinence 14.94 11.89 115 810134 11375 49783500
Flank pain 14.91 11.89 136 810113 12979 49781896
Tongue oedema 14.90 11.89 24 810225 3815 49791060
Heart rate irregular 14.90 11.89 219 810030 19141 49775734
Respiratory tract infection 14.89 11.89 641 809608 31376 49763499
Follicular lymphoma 14.88 11.89 12 810237 78 49794797
Tendon graft 14.84 11.89 6 810243 6 49794869
Metastases to reproductive organ 14.84 11.89 6 810243 6 49794869
Breast cancer metastatic 14.80 11.89 101 810148 10263 49784612
Myeloid leukaemia 14.77 11.89 22 810227 306 49794569
Oesophageal squamous cell carcinoma 14.77 11.89 14 810235 116 49794759
Mucosal necrosis 14.74 11.89 8 810241 23 49794852
Acute lymphocytic leukaemia 14.73 11.89 73 810176 2168 49792707
Genital infection 14.70 11.89 10 810239 48 49794827
Coronary artery occlusion 14.60 11.89 66 810183 7437 49787438
Infusion site reaction 14.60 11.89 72 810177 2134 49792741
Exposure to communicable disease 14.56 11.89 29 810220 516 49794359
Endometrial adenocarcinoma 14.51 11.89 44 810205 1031 49793844
Chronic graft versus host disease in liver 14.50 11.89 20 810229 258 49794617
Diabetic metabolic decompensation 14.50 11.89 3 810246 1477 49793398
Spinal disorder 14.48 11.89 199 810050 8071 49786804
Night sweats 14.48 11.89 667 809582 32907 49761968
Carbohydrate antigen 125 increased 14.44 11.89 11 810238 2456 49792419
Maternal exposure before pregnancy 14.39 11.89 145 810104 5452 49789423
Eye infection toxoplasmal 14.39 11.89 20 810229 260 49794615
Intramedullary rod insertion 14.38 11.89 7 810242 1993 49792882
Cytomegalovirus enteritis 14.37 11.89 18 810231 210 49794665
Injection site hypersensitivity 14.32 11.89 62 810187 1738 49793137
Thyroid cancer 14.31 11.89 115 810134 4054 49790821
Thrombotic thrombocytopenic purpura 14.30 11.89 22 810227 3563 49791312
Blood creatine increased 14.30 11.89 36 810213 4851 49790024
Keratitis 14.29 11.89 78 810171 2407 49792468
Tubular breast carcinoma 14.26 11.89 9 810240 37 49794838
Sputum increased 14.26 11.89 6 810243 1861 49793014
Metastases to liver 14.25 11.89 231 810018 19873 49775002
Lower respiratory tract inflammation 14.25 11.89 13 810236 102 49794773
Skin mass 14.17 11.89 135 810114 5000 49789875
Granulomatous dermatitis 14.15 11.89 13 810236 103 49794772
Product monitoring error 14.14 11.89 14 810235 2750 49792125
Influenza 14.08 11.89 1639 808610 87899 49706976
Extremity contracture 14.05 11.89 48 810201 1200 49793675
Quadrantanopia 14.05 11.89 8 810241 26 49794849
Intentional product use issue 14.04 11.89 1422 808827 75496 49719379
Abscess limb 14.04 11.89 117 810132 4170 49790705
Fracture 14.02 11.89 361 809888 16472 49778403
Listeriosis 14.01 11.89 51 810198 1317 49793558
Blood parathyroid hormone increased 13.99 11.89 15 810234 2839 49792036
Femoroacetabular impingement 13.98 11.89 7 810242 16 49794859
Cervix carcinoma 13.98 11.89 79 810170 2471 49792404
Maternal exposure during breast feeding 13.94 11.89 19 810230 3235 49791640
Bone density abnormal 13.93 11.89 90 810159 2955 49791920
Abscess bacterial 13.91 11.89 17 810232 193 49794682
Rotator cuff syndrome 13.90 11.89 261 809988 11283 49783592
Herpes zoster oticus 13.90 11.89 19 810230 243 49794632
Vasculitic rash 13.89 11.89 48 810201 1207 49793668
Tachyarrhythmia 13.84 11.89 28 810221 4077 49790798
Perirectal abscess 13.82 11.89 38 810211 841 49794034
Nephrogenic anaemia 13.81 11.89 5 810244 1700 49793175
Gastrointestinal lymphoma 13.81 11.89 10 810239 54 49794821
Prosthesis implantation 13.81 11.89 10 810239 54 49794821
Drug level increased 13.79 11.89 221 810028 19047 49775828
Self-medication 13.78 11.89 10 810239 2289 49792586
Homicidal ideation 13.77 11.89 5 810244 1697 49793178
T-cell lymphoma 13.76 11.89 31 810218 603 49794272
Right ventricular dysfunction 13.76 11.89 4 810245 1564 49793311
Breath sounds abnormal 13.74 11.89 71 810178 7721 49787154
Septic arthritis staphylococcal 13.72 11.89 24 810225 385 49794490
Herpes simplex meningoencephalitis 13.70 11.89 7 810242 17 49794858
Spinal meningioma benign 13.69 11.89 13 810236 108 49794767
Generalised oedema 13.68 11.89 147 810102 13584 49781291
Erythrodermic psoriasis 13.68 11.89 39 810210 882 49793993
Abdominal pain upper 13.63 11.89 2292 807957 157017 49637858
Pertussis 13.63 11.89 31 810218 607 49794268
Shock haemorrhagic 13.63 11.89 78 810171 8266 49786609
Polydipsia 13.62 11.89 18 810231 3106 49791769
Red blood cell sedimentation rate decreased 13.62 11.89 15 810234 151 49794724
Poor quality product administered 13.61 11.89 15 810234 2804 49792071
Cutaneous sarcoidosis 13.60 11.89 21 810228 302 49794573
Musculoskeletal chest pain 13.58 11.89 211 810038 18275 49776600
Foreign body sensation in eyes 13.54 11.89 6 810243 1805 49793070
Ventricular hypokinesia 13.54 11.89 27 810222 3953 49790922
Ventricular hypertrophy 13.54 11.89 19 810230 3196 49791679
Cerebral haematoma 13.50 11.89 19 810230 3192 49791683
Bursitis infective 13.49 11.89 47 810202 1187 49793688
Mean cell volume decreased 13.47 11.89 80 810169 2549 49792326
Steroid dependence 13.46 11.89 22 810227 333 49794542
Pneumocystis jirovecii infection 13.45 11.89 48 810201 1227 49793648
Fontanelle bulging 13.45 11.89 5 810244 3 49794872
Local reaction 13.45 11.89 29 810220 547 49794328
Blood chloride increased 13.44 11.89 12 810237 2476 49792399
Serum amyloid A protein increased 13.41 11.89 13 810236 111 49794764
Candida pneumonia 13.41 11.89 13 810236 111 49794764
Product name confusion 13.40 11.89 10 810239 57 49794818
Renal artery stenosis 13.38 11.89 5 810244 1667 49793208
Localised oedema 13.37 11.89 37 810212 4830 49790045
DNA antibody positive 13.36 11.89 21 810228 307 49794568
Cranial nerve disorder 13.32 11.89 22 810227 336 49794539
Pulmonary function test decreased 13.32 11.89 21 810228 3367 49791508
Laryngitis 13.29 11.89 248 810001 10708 49784167
Vaginal cancer 13.29 11.89 18 810231 228 49794647
Ovarian epithelial cancer 13.28 11.89 20 810229 281 49794594
Ototoxicity 13.26 11.89 44 810205 1083 49793792
Chromosomal deletion 13.22 11.89 8 810241 30 49794845
Device alarm issue 13.22 11.89 3 810246 1385 49793490
Metabolic disorder 13.21 11.89 42 810207 5244 49789631
Corneal oedema 13.20 11.89 3 810246 1384 49793491
Necrotising retinitis 13.18 11.89 20 810229 283 49794592
Pulmonary granuloma 13.17 11.89 48 810201 1240 49793635
Laryngitis viral 13.17 11.89 7 810242 19 49794856
Waldenstrom's macroglobulinaemia 13.17 11.89 7 810242 19 49794856
Therapy interrupted 13.17 11.89 235 810014 19917 49774958
Central venous catheterisation 13.12 11.89 9 810240 2121 49792754
Ear infection bacterial 13.10 11.89 9 810240 44 49794831
Cholesteatoma 13.01 11.89 14 810235 137 49794738
Abnormal faeces 13.00 11.89 30 810219 4166 49790709
Sternal fracture 12.95 11.89 8 810241 1994 49792881
Iridocyclitis 12.94 11.89 66 810183 1983 49792892
Histiocytic sarcoma 12.88 11.89 10 810239 61 49794814
Cytomegalovirus gastrointestinal ulcer 12.88 11.89 5 810244 4 49794871
Cutaneous amyloidosis 12.88 11.89 5 810244 4 49794871
Device related infection 12.86 11.89 244 810005 20491 49774384
Discontinued product administered 12.84 11.89 8 810241 32 49794843
Akinesia 12.83 11.89 4 810245 1495 49793380
Rash morbilliform 12.82 11.89 16 810233 2830 49792045
Subcutaneous abscess 12.81 11.89 127 810122 4755 49790120
Antithrombin III decreased 12.80 11.89 17 810232 211 49794664
Genital cyst 12.80 11.89 9 810240 46 49794829
Drug-device interaction 12.80 11.89 11 810238 79 49794796
Nail psoriasis 12.79 11.89 22 810227 348 49794527
Tuberculosis of central nervous system 12.79 11.89 20 810229 291 49794584
Attention deficit hyperactivity disorder 12.78 11.89 12 810237 2417 49792458
Diabetic eye disease 12.78 11.89 14 810235 140 49794735
Adjustment disorder with depressed mood 12.77 11.89 83 810166 2731 49792144
Application site vesicles 12.76 11.89 3 810246 1352 49793523
Deafness neurosensory 12.75 11.89 119 810130 4382 49790493
Infective exacerbation of bronchiectasis 12.75 11.89 21 810228 320 49794555
Intestinal sepsis 12.73 11.89 18 810231 238 49794637
Menstruation irregular 12.73 11.89 53 810196 6109 49788766
Compartment syndrome 12.71 11.89 8 810241 1974 49792901
Neck deformity 12.70 11.89 64 810185 1914 49792961
Pneumonia adenoviral 12.69 11.89 7 810242 21 49794854
Epstein-Barr virus infection reactivation 12.67 11.89 27 810222 505 49794370
Non-cardiac chest pain 12.67 11.89 48 810201 5684 49789191
Carbon dioxide decreased 12.61 11.89 7 810242 1850 49793025
Staphylococcal sepsis 12.61 11.89 170 810079 6866 49788009
Hair colour changes 12.61 11.89 15 810234 2709 49792166
CSF myelin basic protein increased 12.60 11.89 4 810245 0 49794875
Bursa injury 12.60 11.89 4 810245 0 49794875
Bladder papilloma 12.60 11.89 4 810245 0 49794875
Angioimmunoblastic T-cell lymphoma stage III 12.60 11.89 4 810245 0 49794875
Thymoma malignant 12.60 11.89 4 810245 0 49794875
Leptotrichia infection 12.60 11.89 4 810245 0 49794875
Chronic villitis of unknown etiology 12.60 11.89 4 810245 0 49794875
Torticollis 12.60 11.89 6 810243 1730 49793145
Infusion site rash 12.58 11.89 3 810246 1339 49793536
Photopsia 12.57 11.89 28 810221 3938 49790937
Internal haemorrhage 12.57 11.89 33 810216 4384 49790491
Protein urine present 12.56 11.89 44 810205 5333 49789542
Ovarian granulosa cell tumour 12.50 11.89 6 810243 12 49794863
Infusion site bruising 12.48 11.89 11 810238 2284 49792591
BK virus infection 12.48 11.89 84 810165 2797 49792078
Nasopharyngeal cancer 12.46 11.89 7 810242 22 49794853
Loose body in joint 12.45 11.89 45 810204 1158 49793717
Combined immunodeficiency 12.42 11.89 12 810237 102 49794773
Cutaneous lymphoma 12.41 11.89 14 810235 145 49794730
Device failure 12.41 11.89 46 810203 5482 49789393
Lipodystrophy acquired 12.40 11.89 3 810246 1326 49793549
Diffuse alveolar damage 12.39 11.89 35 810214 787 49794088
Toxic leukoencephalopathy 12.38 11.89 30 810219 613 49794262
Gelatinous transformation of the bone marrow 12.37 11.89 5 810244 5 49794870
Bowen's disease 12.34 11.89 17 810232 219 49794656
Orthopnoea 12.34 11.89 48 810201 5641 49789234
Panic reaction 12.32 11.89 24 810225 3545 49791330
Mucocutaneous leishmaniasis 12.30 11.89 21 810228 330 49794545
Plasmacytoma 12.30 11.89 12 810237 2373 49792502
Skin burning sensation 12.30 11.89 104 810145 10081 49784794
Soft tissue swelling 12.30 11.89 39 810210 937 49793938
Tongue ulceration 12.28 11.89 88 810161 2992 49791883
Productive cough 12.27 11.89 704 809545 51990 49742885
N-terminal prohormone brain natriuretic peptide increased 12.27 11.89 6 810243 1704 49793171
Chloroma 12.26 11.89 16 810233 195 49794680
Psychogenic seizure 12.26 11.89 5 810244 1580 49793295
Duodenal ulcer haemorrhage 12.25 11.89 10 810239 2156 49792719
Vulval cancer 12.24 11.89 31 810218 652 49794223
Polycystic ovaries 12.24 11.89 13 810236 2471 49792404
Immunisation reaction 12.24 11.89 7 810242 23 49794852
Monoclonal gammopathy 12.23 11.89 29 810220 584 49794291
Ocular lymphoma 12.23 11.89 9 810240 50 49794825
Allergy to vaccine 12.23 11.89 15 810234 171 49794704
Hepatic necrosis 12.22 11.89 43 810206 5205 49789670
Lung adenocarcinoma stage III 12.20 11.89 6 810243 13 49794862
Parapsoriasis 12.16 11.89 12 810237 105 49794770
Vaginal discharge 12.16 11.89 43 810206 5197 49789678
Anal cancer 12.14 11.89 25 810224 456 49794419
Conduction disorder 12.11 11.89 3 810246 1305 49793570
International normalised ratio fluctuation 12.10 11.89 68 810181 2122 49792753
Blood pressure abnormal 12.09 11.89 138 810111 12609 49782266
Red blood cells urine positive 12.09 11.89 16 810233 2759 49792116
Vitreous floaters 12.07 11.89 44 810205 5270 49789605
Gastrointestinal sounds abnormal 12.07 11.89 25 810224 3609 49791266
Pulmonary thrombosis 12.04 11.89 71 810178 7470 49787405
Intertrigo 12.03 11.89 22 810227 366 49794509
Loss of control of legs 12.02 11.89 3 810246 1298 49793577
Chemotherapeutic drug level increased 12.02 11.89 13 810236 128 49794747
Anovulatory cycle 12.02 11.89 13 810236 128 49794747
Graft versus host disease in lung 12 11.89 21 810228 337 49794538
Joint tuberculosis 11.99 11.89 12 810237 107 49794768
Neoplasm malignant 11.99 11.89 479 809770 23236 49771639
Bursitis infective staphylococcal 11.98 11.89 8 810241 37 49794838
Infusion site warmth 11.97 11.89 4 810245 1430 49793445
Bone cyst 11.96 11.89 64 810185 1960 49792915
Second primary malignancy 11.96 11.89 166 810083 6748 49788127
Tension 11.96 11.89 16 810233 2746 49792129
Papilloma viral infection 11.96 11.89 47 810202 1260 49793615
Intervertebral disc compression 11.93 11.89 38 810211 915 49793960
Placental disorder 11.92 11.89 4 810245 1426 49793449
Myxoid liposarcoma 11.91 11.89 5 810244 6 49794869

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 4388.07 11.18 10170 269495 353000 28941862
Drug intolerance 1452.23 11.18 2027 277638 46352 29248510
Joint swelling 1320.72 11.18 1964 277701 47666 29247196
Death 1309.66 11.18 813 278852 341271 28953591
Rheumatoid arthritis 1200.70 11.18 1500 278165 30652 29264210
Synovitis 983.14 11.18 819 278846 10071 29284791
Arthralgia 965.01 11.18 3206 276459 136411 29158451
Treatment failure 941.20 11.18 1433 278232 35506 29259356
Psoriasis 886.54 11.18 1296 278369 30931 29263931
Therapeutic product effect incomplete 756.92 11.18 1344 278321 37961 29256901
Psoriatic arthropathy 747.29 11.18 804 278861 13887 29280975
Drug abuse 707.52 11.18 9 279656 79874 29214988
Completed suicide 701.47 11.18 37 279628 90209 29204653
Musculoskeletal stiffness 699.68 11.18 1264 278401 36194 29258668
Therapeutic product effect decreased 625.72 11.18 1052 278613 28399 29266463
Mucosal inflammation 619.33 11.18 1089 278576 30506 29264356
Acute graft versus host disease 540.13 11.18 445 279220 5379 29289483
Contraindicated product administered 529.01 11.18 753 278912 17513 29277349
Drug hypersensitivity 515.79 11.18 1620 278045 66786 29228076
Arthropathy 509.35 11.18 808 278857 20746 29274116
Lymphoproliferative disorder 462.91 11.18 292 279373 2235 29292627
Hypotension 446.34 11.18 719 278946 193635 29101227
Febrile neutropenia 417.80 11.18 2131 277534 110109 29184753
Arthritis 402.07 11.18 792 278873 24227 29270635
Chronic graft versus host disease 388.64 11.18 315 279350 3714 29291148
Leukoencephalopathy 377.13 11.18 301 279364 3466 29291396
Stomatitis 375.97 11.18 978 278687 36135 29258727
Constipation 369.03 11.18 322 279343 113838 29181024
Dyspnoea 365.58 11.18 1720 277945 325012 28969850
Bone erosion 359.29 11.18 258 279407 2502 29292360
Rhabdomyolysis 355.96 11.18 71 279594 60737 29234125
Posterior reversible encephalopathy syndrome 343.09 11.18 424 279241 8552 29286310
Hyperkalaemia 338.49 11.18 82 279583 61310 29233552
Fall 333.12 11.18 739 278926 176439 29118423
Drug clearance decreased 328.33 11.18 191 279474 1239 29293623
C-reactive protein abnormal 320.57 11.18 351 279314 6185 29288677
Pain 318.81 11.18 2735 276930 168697 29126165
Dehydration 308.32 11.18 379 279286 114369 29180493
Dizziness 297.21 11.18 868 278797 188816 29106046
Confusional state 284.84 11.18 482 279183 127395 29167467
Graft versus host disease 267.12 11.18 389 279276 9239 29285623
Apparent death 258.57 11.18 235 279430 3269 29291593
Acute graft versus host disease in skin 257.98 11.18 267 279398 4397 29290465
Cardiac failure congestive 255.92 11.18 209 279456 76372 29218490
Pancytopenia 255.24 11.18 1499 278166 81669 29213193
Acute kidney injury 251.07 11.18 1477 278188 263790 29031072
Bradycardia 250.97 11.18 155 279510 65474 29229388
Cardiac arrest 247.91 11.18 266 279399 85325 29209537
Pneumocystis jirovecii pneumonia 239.71 11.18 506 279159 16273 29278589
Intentional overdose 236.15 11.18 40 279625 38488 29256374
Syncope 235.53 11.18 253 279412 81118 29213744
International normalised ratio increased 235.47 11.18 64 279601 44308 29250554
Product use in unapproved indication 233.98 11.18 1514 278151 85361 29209501
Venoocclusive liver disease 233.19 11.18 307 279358 6610 29288252
Liver function test increased 231.88 11.18 409 279256 11476 29283386
Red blood cell sedimentation rate increased 231.47 11.18 318 279347 7143 29287719
Diarrhoea 224.11 11.18 2041 277624 330657 28964205
Pulmonary fibrosis 220.39 11.18 468 279197 15114 29279748
Febrile bone marrow aplasia 220.10 11.18 308 279357 7043 29287819
Pain in extremity 217.72 11.18 1786 277879 108647 29186215
Mobility decreased 216.01 11.18 634 279031 25146 29269716
Plasma cell myeloma 215.77 11.18 44 279621 37071 29257791
Overdose 214.95 11.18 263 279402 79556 29215306
Epstein-Barr virus infection 213.93 11.18 288 279377 6341 29288521
Red blood cell sedimentation rate abnormal 213.59 11.18 176 279489 2127 29292735
Decreased appetite 211.85 11.18 687 278978 144655 29150207
C-reactive protein increased 211.84 11.18 905 278760 43358 29251504
Tuberculosis 211.73 11.18 299 279366 6897 29287965
Hypoglycaemia 208.48 11.18 98 279567 48248 29246614
Electrocardiogram QT prolonged 207.69 11.18 44 279621 36093 29258769
Hypofibrinogenaemia 206.19 11.18 145 279520 1356 29293506
Asthenia 205.31 11.18 1195 278470 214055 29080807
Hallucination 204.89 11.18 83 279582 44629 29250233
Myelopathy 202.45 11.18 160 279505 1814 29293048
Somnolence 199.25 11.18 365 279300 93590 29201272
Atrial fibrillation 198.78 11.18 440 279225 105206 29189656
Bone marrow failure 195.59 11.18 638 279027 26811 29268051
Hospitalisation 195.57 11.18 95 279570 45893 29248969
Anaemia 192.99 11.18 1113 278552 199838 29095024
Fatigue 191.97 11.18 1994 277671 314827 28980035
Osteoarthritis 187.29 11.18 481 279184 17622 29277240
Ankylosing spondylitis 187.19 11.18 214 279451 3962 29290900
Gastrointestinal haemorrhage 183.26 11.18 293 279372 79240 29215622
Blood glucose increased 182.51 11.18 173 279492 58811 29236051
Hand deformity 181.47 11.18 155 279510 1975 29292887
Malignant neoplasm progression 180.87 11.18 261 279404 73598 29221264
Hyponatraemia 180.86 11.18 224 279441 67409 29227453
Aggression 178.09 11.18 57 279608 35484 29259378
Joint stiffness 175.83 11.18 319 279346 9154 29285708
Epstein-Barr virus associated lymphoproliferative disorder 174.24 11.18 139 279526 1599 29293263
Diverticulitis 172.52 11.18 460 279205 17244 29277618
Haemoglobin decreased 170.84 11.18 494 279171 107881 29186981
Basal cell carcinoma 170.50 11.18 445 279220 16465 29278397
Agitation 166.45 11.18 144 279521 51160 29243702
Cardio-respiratory arrest 165.42 11.18 141 279524 50460 29244402
Inflammation 161.68 11.18 528 279137 22200 29272662
Drug interaction 158.55 11.18 1154 278511 196231 29098631
Diffuse large B-cell lymphoma 157.55 11.18 242 279423 6034 29288828
Knee arthroplasty 154.34 11.18 230 279435 5579 29289283
Loss of consciousness 154.05 11.18 291 279374 73765 29221097
Haematotoxicity 153.88 11.18 248 279417 6451 29288411
Off label use 153.81 11.18 3824 275841 296976 28997886
Lymphoma 151.67 11.18 306 279359 9522 29285340
Loss of personal independence in daily activities 151.38 11.18 557 279108 24883 29269979
Blood creatine phosphokinase increased 149.85 11.18 100 279565 40544 29254318
Rheumatoid nodule 146.26 11.18 137 279528 1985 29292877
Gastrointestinal disorder 145.95 11.18 598 279067 28108 29266754
Graft versus host disease in gastrointestinal tract 144.42 11.18 166 279499 3092 29291770
Neurotoxicity 142.69 11.18 380 279285 14233 29280629
Haemophagocytic lymphohistiocytosis 142.23 11.18 310 279355 10194 29284668
Suicide attempt 141.20 11.18 73 279592 34037 29260825
Infection 140.36 11.18 1221 278444 75530 29219332
Nodule 139.56 11.18 205 279460 4907 29289955
Sedation 138.76 11.18 6 279659 17399 29277463
Neuroleptic malignant syndrome 137.95 11.18 3 279662 16145 29278717
Angiocentric lymphoma 136.46 11.18 61 279604 203 29294659
Histoplasmosis disseminated 135.46 11.18 101 279564 1043 29293819
Anxiety 131.66 11.18 393 279272 84972 29209890
Disability 130.67 11.18 184 279481 4232 29290630
Pulmonary tuberculosis 127.99 11.18 180 279485 4135 29290727
Foot deformity 127.37 11.18 173 279492 3842 29291020
Mouth ulceration 127.22 11.18 294 279371 10061 29284801
Suicidal ideation 123.22 11.18 89 279576 34627 29260235
Pneumonia aspiration 121.73 11.18 101 279564 36636 29258226
Blood creatinine increased 121.26 11.18 406 279259 84696 29210166
Cystitis haemorrhagic 117.75 11.18 184 279481 4658 29290204
Metabolic acidosis 117.02 11.18 110 279555 37552 29257310
Polyarthritis 116.18 11.18 164 279501 3781 29291081
Graft versus host disease in skin 115.48 11.18 151 279514 3228 29291634
Grip strength decreased 115.05 11.18 125 279540 2182 29292680
Arthritis bacterial 114.78 11.18 173 279492 4240 29290622
Herpes zoster 114.57 11.18 575 279090 29477 29265385
Sarcoidosis 114.48 11.18 133 279532 2507 29292355
Acute lymphocytic leukaemia recurrent 112.88 11.18 129 279536 2387 29292475
Foetal exposure during pregnancy 112.35 11.18 93 279572 33774 29261088
Dactylitis 111.85 11.18 74 279591 620 29294242
Acute graft versus host disease in intestine 111.81 11.18 124 279541 2217 29292645
Coma 111.49 11.18 125 279540 39325 29255537
Product use issue 109.39 11.18 847 278818 50597 29244265
Lactic acidosis 109.38 11.18 76 279589 30171 29264691
Visceral leishmaniasis 108.19 11.18 65 279600 451 29294411
Rheumatoid factor positive 108.08 11.18 71 279594 587 29294275
Cardiac failure 107.73 11.18 386 279279 78901 29215961
Joint effusion 107.37 11.18 163 279502 4021 29290841
Product dose omission issue 107.36 11.18 507 279158 95876 29198986
Hypokalaemia 106.37 11.18 195 279470 50008 29244854
Immunosuppression 105.81 11.18 184 279481 5102 29289760
Skin plaque 105.80 11.18 153 279512 3609 29291253
Drug reaction with eosinophilia and systemic symptoms 105.72 11.18 67 279598 27925 29266937
Joint range of motion decreased 104.98 11.18 198 279467 5856 29289006
Cerebrovascular accident 104.78 11.18 374 279291 76537 29218325
Therapeutic response decreased 104.41 11.18 487 279178 24224 29270638
Hepatic enzyme increased 104.04 11.18 610 279055 33189 29261673
Enthesopathy 103.48 11.18 151 279514 3592 29291270
Synovial cyst 102.04 11.18 107 279558 1790 29293072
Delirium 101.63 11.18 134 279531 39263 29255599
Chondropathy 99.98 11.18 77 279588 838 29294024
Cutaneous leishmaniasis 99.93 11.18 46 279619 167 29294695
Epidermal necrosis 99.55 11.18 59 279606 398 29294464
Intentional product misuse 98.85 11.18 109 279556 34552 29260310
Injection site pain 98.85 11.18 584 279081 31862 29263000
Anti-cyclic citrullinated peptide antibody positive 98.13 11.18 73 279592 751 29294111
Abnormal behaviour 96.45 11.18 49 279616 23078 29271784
Swelling 96.11 11.18 617 279048 34666 29260196
Respiratory arrest 95.97 11.18 63 279602 25770 29269092
Orthostatic hypotension 95.80 11.18 47 279618 22582 29272280
Tuberculin test positive 95.35 11.18 80 279585 993 29293869
Sleep disorder due to general medical condition, insomnia type 94.86 11.18 86 279579 1192 29293670
Toxicity to various agents 94.82 11.18 1118 278547 172543 29122319
Nasopharyngitis 93.78 11.18 919 278746 58746 29236116
Impaired work ability 93.53 11.18 181 279484 5459 29289403
Drug withdrawal syndrome 93.41 11.18 27 279638 17957 29276905
Tremor 92.76 11.18 369 279296 73169 29221693
Sacroiliitis 91.93 11.18 80 279585 1047 29293815
Tenosynovitis 90.98 11.18 142 279523 3591 29291271
Chest pain 90.03 11.18 654 279011 111319 29183543
Sopor 89.79 11.18 3 279662 10931 29283931
Acute myocardial infarction 89.16 11.18 204 279461 48234 29246628
Depressed level of consciousness 87.98 11.18 133 279532 36809 29258053
Platelet count decreased 85.77 11.18 608 279057 104064 29190798
Respiratory depression 85.18 11.18 13 279652 13510 29281352
Myocardial infarction 84.48 11.18 653 279012 109643 29185219
Serotonin syndrome 84.38 11.18 30 279635 17482 29277380
Squamous cell carcinoma 83.83 11.18 250 279415 10001 29284861
Hypocalcaemia 82.92 11.18 46 279619 20619 29274243
Rheumatoid factor negative 82.39 11.18 66 279599 764 29294098
Musculoskeletal pain 82.39 11.18 512 279153 28441 29266421
Hyperglycaemia 81.12 11.18 124 279541 34163 29260699
Drug specific antibody present 80.71 11.18 110 279555 2451 29292411
Psychotic disorder 80.67 11.18 46 279619 20308 29274554
Unevaluable event 80.66 11.18 98 279567 29753 29265109
Delusion 80.05 11.18 7 279658 11209 29283653
Prostate cancer 80.04 11.18 463 279202 25064 29269798
Spermatozoa abnormal 79.68 11.18 27 279638 29 29294833
Hepatotoxicity 79.09 11.18 357 279308 17510 29277352
Condition aggravated 78.95 11.18 1875 277790 144420 29150442
Disseminated tuberculosis 78.72 11.18 95 279570 1867 29292995
Peripheral swelling 78.02 11.18 934 278731 62805 29232057
Multiple sclerosis relapse 76.64 11.18 9 279656 11410 29283452
Oedema peripheral 76.56 11.18 619 279046 102938 29191924
Intentional self-injury 76.20 11.18 13 279652 12448 29282414
Malignant melanoma 75.84 11.18 192 279473 6969 29287893
Bone cyst 75.58 11.18 54 279611 519 29294343
Oxidative stress 75.34 11.18 27 279638 39 29294823
Pulmonary toxicity 75.14 11.18 152 279513 4738 29290124
Disease progression 75.07 11.18 460 279205 81456 29213406
Chronic kidney disease 74.88 11.18 144 279521 36272 29258590
Cytomegalovirus infection 74.70 11.18 424 279241 22791 29272071
Restlessness 74.45 11.18 60 279605 22085 29272777
Cardiogenic shock 73.75 11.18 45 279620 19145 29275717
Chemotherapeutic drug level increased 73.21 11.18 37 279628 173 29294689
Blood urea increased 73.13 11.18 95 279570 28017 29266845
Epstein Barr virus positive mucocutaneous ulcer 72.38 11.18 41 279624 251 29294611
Urinary retention 72.01 11.18 119 279546 31779 29263083
Mycobacterium tuberculosis complex test positive 71.79 11.18 67 279598 966 29293896
Sensitivity to weather change 70.96 11.18 77 279588 1342 29293520
Pulmonary mass 70.49 11.18 243 279422 10505 29284357
Dislocation of vertebra 70.32 11.18 45 279620 354 29294508
Uveitis 69.94 11.18 166 279499 5781 29289081
X-ray abnormal 69.93 11.18 48 279617 430 29294432
Melaena 69.74 11.18 117 279548 31059 29263803
Demyelination 68.96 11.18 104 279561 2550 29292312
Diabetic ketoacidosis 68.62 11.18 33 279632 16040 29278822
Hypomagnesaemia 68.48 11.18 40 279625 17428 29277434
Blood pressure fluctuation 68.45 11.18 370 279295 19524 29275338
Inappropriate schedule of product administration 68.40 11.18 682 278983 43790 29251072
Blood potassium increased 67.41 11.18 27 279638 14624 29280238
Extrapyramidal disorder 66.89 11.18 11 279654 10820 29284042
Vein rupture 66.45 11.18 54 279611 639 29294223
Finger deformity 66.19 11.18 67 279598 1073 29293789
Cardiac disorder 66.12 11.18 160 279505 37103 29257759
Foetal methotrexate syndrome 66.07 11.18 18 279647 0 29294862
Atlantoaxial instability 66.04 11.18 41 279624 304 29294558
Epstein-Barr virus infection reactivation 65.95 11.18 49 279616 503 29294359
Haemorrhage 65.55 11.18 213 279452 44859 29250003
Nightmare 65.38 11.18 14 279651 11403 29283459
Venoocclusive disease 65.27 11.18 99 279566 2440 29292422
Skin ulcer 65.23 11.18 351 279314 18489 29276373
Angioedema 64.93 11.18 127 279538 31788 29263074
Wrist deformity 64.86 11.18 41 279624 315 29294547
Skin lesion 64.30 11.18 346 279319 18226 29276636
Fear of injection 64.28 11.18 57 279608 766 29294096
Abscess 64.27 11.18 221 279444 9541 29285321
Spinal instability 63.92 11.18 41 279624 324 29294538
Leukaemia recurrent 63.36 11.18 74 279591 1403 29293459
Joint ankylosis 63.31 11.18 43 279622 378 29294484
Mineral metabolism disorder 63.21 11.18 41 279624 331 29294531
Haematocrit decreased 63.01 11.18 111 279554 28911 29265951
Hip arthroplasty 62.80 11.18 121 279544 3637 29291225
Dysgeusia 62.79 11.18 73 279592 22601 29272261
Coronary artery disease 62.77 11.18 211 279454 43979 29250883
Cytogenetic abnormality 62.54 11.18 56 279609 763 29294099
Renal impairment 62.49 11.18 481 279184 80852 29214010
Complications of bone marrow transplant 62.21 11.18 34 279631 192 29294670
General physical health deterioration 62.07 11.18 647 279018 102210 29192652
Bladder transitional cell carcinoma 61.91 11.18 95 279570 2366 29292496
Myalgia 61.55 11.18 428 279237 73591 29221271
Product quality issue 61.47 11.18 37 279628 15858 29279004
Vomiting 61.44 11.18 1533 278132 210727 29084135
Balance disorder 61.30 11.18 159 279506 36011 29258851
Lymphadenopathy 60.97 11.18 426 279239 24623 29270239
Mucocutaneous ulceration 60.95 11.18 30 279635 131 29294731
Hallucination, visual 60.85 11.18 33 279632 14982 29279880
Full blood count decreased 60.76 11.18 38 279627 15954 29278908
Blood pressure decreased 60.67 11.18 223 279442 45254 29249608
Dyskinesia 60.67 11.18 60 279605 20001 29274861
Oedema 60.49 11.18 189 279476 40294 29254568
Mycobacterial infection 60.44 11.18 81 279584 1775 29293087
Pleurisy 60.13 11.18 128 279537 4139 29290723
Insomnia 60.02 11.18 543 279122 88218 29206644
Histoplasmosis 59.95 11.18 69 279596 1287 29293575
Injury 59.89 11.18 55 279610 18991 29275871
Latent tuberculosis 59.24 11.18 61 279604 998 29293864
Sinus bradycardia 59.20 11.18 18 279647 11585 29283277
Blood potassium decreased 58.94 11.18 38 279627 15696 29279166
Myoclonus 58.87 11.18 26 279639 13283 29281579
Cytomegalovirus chorioretinitis 58.76 11.18 108 279557 3130 29291732
Lung neoplasm malignant 58.49 11.18 280 279385 14077 29280785
Hepatic steatosis 58.38 11.18 288 279377 14658 29280204
Haematemesis 58.30 11.18 89 279576 24537 29270325
Intervertebral disc space narrowing 57.51 11.18 52 279613 718 29294144
Miosis 57.16 11.18 5 279660 8004 29286858
Angioimmunoblastic T-cell lymphoma 57.01 11.18 36 279629 276 29294586
Rheumatoid lung 55.96 11.18 39 279626 359 29294503
Cytomegalovirus infection reactivation 55.83 11.18 108 279557 3256 29291606
Cutaneous T-cell lymphoma 55.83 11.18 65 279600 1228 29293634
Medial tibial stress syndrome 55.80 11.18 19 279646 21 29294841
Pneumonia legionella 55.78 11.18 72 279593 1519 29293343
Dystonia 55.73 11.18 12 279653 9737 29285125
Atrial flutter 55.64 11.18 31 279634 13863 29280999
Abdominal distension 55.59 11.18 234 279431 45677 29249185
Clinodactyly 55.51 11.18 33 279632 224 29294638
Onychoclasis 54.79 11.18 75 279590 1678 29293184
Urinary tract infection 54.60 11.18 430 279235 71924 29222938
Disease recurrence 54.09 11.18 295 279370 15619 29279243
White blood cell count increased 54.06 11.18 178 279487 37338 29257524
Acute graft versus host disease in liver 54.03 11.18 65 279600 1273 29293589
Stevens-Johnson syndrome 53.85 11.18 46 279619 16451 29278411
Disorientation 53.74 11.18 125 279540 29390 29265472
B-cell lymphoma 53.19 11.18 114 279551 3704 29291158
Seronegative arthritis 53.09 11.18 54 279611 870 29293992
Depression 52.84 11.18 532 279133 84615 29210247
Hypertriglyceridaemia 52.55 11.18 173 279492 7302 29287560
Acne cystic 52.51 11.18 41 279624 456 29294406
Limb discomfort 52.36 11.18 204 279461 9364 29285498
Haematuria 52.20 11.18 227 279438 43912 29250950
Musculoskeletal discomfort 52.18 11.18 155 279510 6186 29288676
Ventricular tachycardia 52.09 11.18 83 279582 22491 29272371
Superior sagittal sinus thrombosis 51.79 11.18 32 279633 235 29294627
Engraftment syndrome 51.63 11.18 51 279614 792 29294070
Irritability 51.54 11.18 81 279584 22071 29272791
Joint destruction 51.53 11.18 33 279632 260 29294602
Anal fistula 51.41 11.18 119 279546 4076 29290786
Fluid retention 51.24 11.18 90 279575 23470 29271392
Kidney transplant rejection 51.02 11.18 4 279661 7001 29287861
Cognitive disorder 50.90 11.18 90 279575 23409 29271453
Chronic graft versus host disease in skin 50.79 11.18 50 279615 773 29294089
Aplasia 50.61 11.18 116 279549 3947 29290915
Adenovirus infection 50.01 11.18 122 279543 4325 29290537
Pulmonary oedema 49.79 11.18 221 279444 42514 29252348
Vision blurred 49.74 11.18 203 279462 39973 29254889
Hypersensitivity 49.31 11.18 738 278927 52165 29242697
Wheezing 49.08 11.18 156 279509 33084 29261778
Tachycardia 48.93 11.18 443 279222 71967 29222895
Drug eruption 48.84 11.18 298 279367 16443 29278419
Blood sodium decreased 48.41 11.18 41 279624 14726 29280136
Blood glucose decreased 48.22 11.18 27 279638 12042 29282820
Flushing 47.94 11.18 129 279536 28863 29265999
Hypovolaemia 47.87 11.18 9 279656 8036 29286826
Abscess limb 47.62 11.18 98 279567 3093 29291769
Paranoia 47.45 11.18 17 279648 9860 29285002
Injection site swelling 46.91 11.18 195 279470 9222 29285640
Unresponsive to stimuli 46.89 11.18 105 279560 25021 29269841
Seizure 46.77 11.18 610 279055 92513 29202349
Erectile dysfunction 46.69 11.18 61 279604 17948 29276914
Intestinal polyp 46.59 11.18 50 279615 860 29294002
Bursitis 46.50 11.18 125 279540 4707 29290155
Erythrodermic psoriasis 46.42 11.18 47 279618 753 29294109
Photosensitivity reaction 46.35 11.18 192 279473 9066 29285796
Haemoptysis 46.08 11.18 142 279523 30408 29264454
Akathisia 46.03 11.18 5 279660 6737 29288125
Injection site bruising 45.94 11.18 167 279498 7413 29287449
Pericarditis 45.73 11.18 184 279481 8573 29286289
Neuropathy peripheral 45.64 11.18 440 279225 70587 29224275
Juvenile idiopathic arthritis 45.64 11.18 61 279604 1333 29293529
Swollen tongue 45.44 11.18 30 279635 12236 29282626
Pulmonary hypertension 45.26 11.18 66 279599 18542 29276320
Injection site haemorrhage 45.24 11.18 178 279487 8208 29286654
Squamous cell carcinoma of lung 45.19 11.18 66 279599 1571 29293291
Anhedonia 45.17 11.18 7 279658 7193 29287669
Skin cancer 45.08 11.18 179 279486 8289 29286573
Palpitations 44.73 11.18 158 279507 32446 29262416
Lupus-like syndrome 44.31 11.18 78 279587 2184 29292678
Mental status changes 44.17 11.18 175 279490 34752 29260110
Muscle rigidity 43.86 11.18 17 279648 9394 29285468
Clear cell renal cell carcinoma 43.78 11.18 51 279614 964 29293898
Arthritis infective 43.65 11.18 88 279577 2736 29292126
Lung disorder 43.52 11.18 459 279206 29903 29264959
Joint arthroplasty 43.46 11.18 42 279623 634 29294228
Hepatic cirrhosis 43.34 11.18 259 279406 14185 29280677
Acute myeloid leukaemia 43.26 11.18 286 279379 16227 29278635
Post transplant lymphoproliferative disorder 43.06 11.18 132 279533 5361 29289501
Peritonitis bacterial 42.74 11.18 3 279662 5753 29289109
Thrombotic microangiopathy 42.65 11.18 179 279486 8502 29286360
Oral herpes 42.37 11.18 116 279549 4416 29290446
Treatment noncompliance 42.21 11.18 105 279560 24122 29270740
Rash 42.01 11.18 1422 278243 188397 29106465
Hepatic encephalopathy 41.75 11.18 37 279628 12998 29281864
Colitis ulcerative 41.59 11.18 234 279431 12535 29282327
Upper gastrointestinal haemorrhage 41.36 11.18 91 279574 21823 29273039
Fear 41.36 11.18 19 279646 9485 29285377
Rash maculo-papular 40.98 11.18 107 279558 24182 29270680
Contraindication to medical treatment 40.92 11.18 34 279631 416 29294446
Immunodeficiency 40.87 11.18 113 279552 4327 29290535
Intentional product use issue 40.83 11.18 596 279069 41902 29252960
Arrhythmia 40.81 11.18 155 279510 31158 29263704
Osteonecrosis of jaw 40.71 11.18 58 279607 16452 29278410
Subdural haematoma 40.02 11.18 69 279596 18124 29276738
Arachnoiditis 39.83 11.18 30 279635 315 29294547
Transient ischaemic attack 39.65 11.18 102 279563 23168 29271694
Interstitial lung disease 39.51 11.18 766 278899 56952 29237910
Graft versus host disease in liver 39.41 11.18 50 279615 1036 29293826
Hyperbilirubinaemia 39.33 11.18 259 279406 14675 29280187
Joint lock 39.33 11.18 51 279614 1081 29293781
Red blood cell count decreased 39.33 11.18 118 279547 25484 29269378
Molluscum contagiosum 39.32 11.18 27 279638 242 29294620
Lymph node tuberculosis 39.24 11.18 33 279632 411 29294451
Tooth fracture 39.20 11.18 90 279575 3066 29291796
Poisoning 39.01 11.18 23 279642 9970 29284892
Troponin increased 38.97 11.18 19 279646 9164 29285698
Therapy partial responder 38.97 11.18 123 279542 5076 29289786
End stage renal disease 38.90 11.18 12 279653 7652 29287210
Dysphagia 38.88 11.18 332 279333 54594 29240268
Glioma 38.86 11.18 28 279637 273 29294589
Wrong technique in product usage process 38.78 11.18 159 279506 31269 29263593
Peritoneal tuberculosis 38.62 11.18 30 279635 331 29294531
Haematoma 38.59 11.18 103 279562 23109 29271753
Alanine aminotransferase abnormal 38.59 11.18 86 279579 2871 29291991
Tardive dyskinesia 38.30 11.18 3 279662 5255 29289607
Cerebral haemorrhage 38.14 11.18 160 279505 31266 29263596
Faeces discoloured 38.04 11.18 42 279623 13309 29281553
Craniosynostosis 37.88 11.18 28 279637 285 29294577
Cerebral venous sinus thrombosis 37.86 11.18 31 279634 371 29294491
Hyperhidrosis 37.68 11.18 409 279256 64131 29230731
Progressive multifocal leukoencephalopathy 37.68 11.18 173 279492 8546 29286316
Mass 37.60 11.18 150 279515 6961 29287901
Hepatic fibrosis 37.41 11.18 90 279575 3162 29291700
Myelosuppression 37.17 11.18 220 279445 12007 29282855
Epstein-Barr viraemia 37.04 11.18 46 279619 932 29293930
Aphthous ulcer 36.92 11.18 103 279562 3965 29290897
Pneumonia cryptococcal 36.88 11.18 41 279624 735 29294127
Pulmonary thrombosis 36.76 11.18 141 279524 6424 29288438
Non-Hodgkin's lymphoma 36.56 11.18 57 279608 1440 29293422
Hiccups 36.55 11.18 19 279646 8834 29286028
Therapeutic response shortened 36.51 11.18 114 279551 4677 29290185
Therapy non-responder 36.50 11.18 450 279215 30461 29264401
Cytomegalovirus viraemia 36.43 11.18 137 279528 6183 29288679
Oral disorder 36.38 11.18 98 279567 3695 29291167
Ileal stenosis 36.05 11.18 51 279614 1178 29293684
Memory impairment 35.94 11.18 200 279465 36270 29258592
Cytology abnormal 35.91 11.18 30 279635 370 29294492
Spondyloarthropathy 35.68 11.18 33 279632 470 29294392
Myelodysplastic syndrome 35.61 11.18 289 279376 17505 29277357
Decreased immune responsiveness 35.43 11.18 55 279610 1384 29293478
Osteonecrosis 35.32 11.18 234 279431 13285 29281577
Viral haemorrhagic cystitis 35.26 11.18 44 279621 896 29293966
Neutrophil count increased 35.16 11.18 53 279612 14689 29280173
Amnesia 35.04 11.18 104 279561 22539 29272323
Aspiration 34.95 11.18 27 279638 10153 29284709
Premature baby 34.93 11.18 69 279596 17211 29277651
Fibromyalgia 34.92 11.18 77 279588 2552 29292310
Disturbance in attention 34.92 11.18 96 279569 21328 29273534
Eosinophilia 34.86 11.18 101 279564 22060 29272802
Ill-defined disorder 34.78 11.18 209 279456 11469 29283393
Faecal calprotectin increased 34.77 11.18 57 279608 1504 29293358
Hypervolaemia 34.66 11.18 71 279594 17474 29277388
Blood calcium decreased 34.63 11.18 22 279643 9160 29285702
Intervertebral discitis 34.59 11.18 60 279605 1660 29293202
Inflammatory marker increased 34.42 11.18 94 279571 3573 29291289
Arthrodesis 34.35 11.18 31 279634 427 29294435
Hypoxia 34.15 11.18 285 279380 47094 29247768
Failure to thrive 34.00 11.18 15 279650 7669 29287193
Device occlusion 33.96 11.18 6 279659 5602 29289260
Heart rate increased 33.92 11.18 222 279443 38716 29256146
Obliterative bronchiolitis 33.76 11.18 47 279618 1069 29293793
Mania 33.73 11.18 20 279645 8643 29286219
Angina pectoris 33.67 11.18 142 279523 27708 29267154
Head injury 33.57 11.18 63 279602 16018 29278844
Chromaturia 33.56 11.18 43 279622 12759 29282103
Hallucination, auditory 33.50 11.18 25 279640 9568 29285294
Gingivitis ulcerative 33.38 11.18 14 279651 38 29294824
Mucormycosis 33.28 11.18 116 279549 5042 29289820
Withdrawal syndrome 33.09 11.18 33 279632 10959 29283903
Facial paralysis 33.06 11.18 179 279486 9450 29285412
Speech disorder 32.90 11.18 113 279552 23403 29271459
Tenderness 32.89 11.18 124 279541 5603 29289259
Poisoning deliberate 32.87 11.18 7 279658 5724 29289138
Fungal infection 32.86 11.18 232 279433 13453 29281409
Pustular psoriasis 32.81 11.18 55 279610 1479 29293383
Engraft failure 32.81 11.18 29 279636 388 29294474
Blood stem cell transplant failure 32.75 11.18 29 279636 389 29294473
Central nervous system leukaemia 32.73 11.18 24 279641 241 29294621
Jaundice 32.63 11.18 154 279511 29142 29265720
Drug tolerance decreased 32.52 11.18 51 279614 1295 29293567
Acute promyelocytic leukaemia 32.51 11.18 30 279635 426 29294436
Atrial septal defect 32.08 11.18 12 279653 6777 29288085
Full blood count abnormal 32.06 11.18 58 279607 14955 29279907
Schizophrenia 32.05 11.18 11 279654 6554 29288308
Hyperthyroidism 31.95 11.18 21 279644 8587 29286275
Cytotoxic oedema 31.92 11.18 20 279645 151 29294711
Osteosclerosis 31.90 11.18 46 279619 1082 29293780
Oropharyngeal pain 31.89 11.18 420 279245 28865 29265997
Tubulointerstitial nephritis 31.89 11.18 75 279590 17568 29277294
Labelled drug-drug interaction medication error 31.71 11.18 41 279624 12118 29282744
Cutaneous lymphoma 31.63 11.18 16 279649 75 29294787
Skin erosion 31.63 11.18 58 279607 1678 29293184
Dry mouth 31.62 11.18 103 279562 21681 29273181
Depressed mood 31.29 11.18 68 279597 16380 29278482
Staphylococcal sepsis 31.28 11.18 166 279499 8696 29286166
Venous injury 31.10 11.18 24 279641 262 29294600
Right ventricular failure 31.02 11.18 18 279647 7872 29286990
Lung cancer metastatic 31.02 11.18 70 279595 2357 29292505
Oral mucosa erosion 30.97 11.18 39 279626 802 29294060
Lymphocyte count decreased 30.92 11.18 87 279578 19184 29275678
Acute myeloid leukaemia recurrent 30.59 11.18 58 279607 1722 29293140
Salivary hypersecretion 30.44 11.18 16 279649 7393 29287469
Herpes simplex oesophagitis 30.42 11.18 18 279647 121 29294741
Bronchial carcinoma 30.28 11.18 40 279625 864 29293998
Exposure during pregnancy 30.25 11.18 22 279643 8532 29286330
Presyncope 30.21 11.18 67 279598 16022 29278840
Gastrointestinal toxicity 30.11 11.18 64 279601 2067 29292795
Dysuria 29.94 11.18 110 279555 22330 29272532
Inflammatory bowel disease 29.92 11.18 67 279598 2244 29292618
Frequent bowel movements 29.88 11.18 169 279496 9070 29285792
Palmar-plantar erythrodysaesthesia syndrome 29.78 11.18 59 279606 14700 29280162
Myelitis transverse 29.73 11.18 41 279624 924 29293938
Gastric disorder 29.63 11.18 188 279477 10516 29284346
Pleuropericarditis 29.63 11.18 21 279644 199 29294663
Drug ineffective for unapproved indication 29.61 11.18 233 279432 13981 29280881
Shock haemorrhagic 29.53 11.18 28 279637 9523 29285339
Bone tuberculosis 29.43 11.18 25 279640 316 29294546
Neutropenia 29.39 11.18 1525 278140 130186 29164676
Supraventricular tachycardia 29.38 11.18 30 279635 9854 29285008
Vertigo 29.28 11.18 107 279558 21754 29273108
Glioblastoma multiforme 29.18 11.18 34 279631 643 29294219
Bursitis infective 29.17 11.18 30 279635 490 29294372
Mucosal toxicity 29.15 11.18 20 279645 179 29294683
Colitis 29.13 11.18 436 279229 30812 29264050
Diffuse large B-cell lymphoma recurrent 28.94 11.18 71 279594 2526 29292336
Osteopenia 28.88 11.18 96 279569 4072 29290790
Ventricular fibrillation 28.86 11.18 67 279598 15766 29279096
Scleroderma 28.66 11.18 48 279617 1290 29293572
Spinal pain 28.50 11.18 106 279559 4758 29290104
Serum procollagen type III N-terminal propeptide increased 28.49 11.18 13 279652 46 29294816
Lethargy 28.49 11.18 223 279442 37357 29257505
Cytomegalovirus test positive 28.48 11.18 84 279581 3339 29291523
Lung adenocarcinoma 28.43 11.18 91 279574 3784 29291078
Cerebral salt-wasting syndrome 28.28 11.18 13 279652 47 29294815
Adult T-cell lymphoma/leukaemia 28.17 11.18 17 279648 119 29294743
Transaminases increased 28.10 11.18 333 279332 22329 29272533
Cardiac failure chronic 28.03 11.18 13 279652 6454 29288408
Varicella zoster virus infection 27.96 11.18 50 279615 1418 29293444
Tricuspid valve incompetence 27.89 11.18 23 279642 8371 29286491
Tonsil cancer 27.85 11.18 39 279626 892 29293970
Gliosis 27.78 11.18 18 279647 145 29294717
Tropical infectious disease 27.75 11.18 12 279653 36 29294826
Pseudostroke 27.75 11.18 12 279653 36 29294826
White blood cell count decreased 27.70 11.18 589 279076 82773 29212089
Rheumatoid factor increased 27.68 11.18 30 279635 522 29294340
Poor venous access 27.67 11.18 79 279586 3082 29291780
Lipoma 27.59 11.18 49 279616 1382 29293480
Axial spondyloarthritis 27.58 11.18 22 279643 253 29294609
Aspergillus infection 27.56 11.18 183 279482 10398 29284464
Minimal residual disease 27.28 11.18 24 279641 319 29294543
Skin mass 27.24 11.18 83 279582 3360 29291502
Anger 27.10 11.18 38 279627 10852 29284010
Renal injury 27.02 11.18 34 279631 10168 29284694
Impaired healing 27.02 11.18 220 279445 13338 29281524
Electrocardiogram abnormal 26.99 11.18 18 279647 7304 29287558
Liver disorder 26.98 11.18 390 279275 27359 29267503
Thinking abnormal 26.93 11.18 8 279657 5228 29289634
Bundle branch block right 26.87 11.18 15 279650 6702 29288160
Complications of transplanted kidney 26.82 11.18 3 279662 3951 29290911
Blood fibrinogen decreased 26.79 11.18 38 279627 880 29293982
Infectious pleural effusion 26.79 11.18 58 279607 1898 29292964
Priapism 26.75 11.18 5 279660 4483 29290379
Psychomotor hyperactivity 26.68 11.18 23 279642 8190 29286672
Chemotherapeutic drug level above therapeutic 26.41 11.18 9 279656 10 29294852
Hypothermia 26.39 11.18 29 279636 9210 29285652
Meningitis tuberculous 26.29 11.18 31 279634 594 29294268
Acute lymphocytic leukaemia 26.27 11.18 69 279596 2562 29292300
Non-alcoholic steatohepatitis 26.18 11.18 35 279630 765 29294097
Human herpesvirus 8 infection 26.12 11.18 36 279629 811 29294051
Myelitis 26.11 11.18 33 279632 681 29294181
Facial paresis 26.10 11.18 69 279596 2572 29292290
Dyspnoea exertional 26.07 11.18 220 279445 36270 29258592
Product substitution issue 25.97 11.18 29 279636 9143 29285719
Bicytopenia 25.97 11.18 55 279610 1772 29293090
Actinomycotic pulmonary infection 25.95 11.18 9 279656 11 29294851
T-cell lymphoma 25.86 11.18 37 279628 864 29293998
Atrioventricular block first degree 25.81 11.18 9 279656 5310 29289552
Tooth loss 25.80 11.18 85 279580 3589 29291273
Incorrect disposal of product 25.77 11.18 22 279643 280 29294582
Cerebral venous thrombosis 25.77 11.18 31 279634 607 29294255
Hepatic enzyme abnormal 25.74 11.18 62 279603 2180 29292682
Angioimmunoblastic T-cell lymphoma stage III 25.69 11.18 7 279658 0 29294862
Joint tuberculosis 25.68 11.18 11 279654 32 29294830
Chronic graft versus host disease in intestine 25.66 11.18 19 279646 194 29294668
Ageusia 25.59 11.18 28 279637 8910 29285952
Soft tissue swelling 25.59 11.18 23 279642 315 29294547
Septic arthritis staphylococcal 25.54 11.18 27 279638 456 29294406
Meningitis haemophilus 25.53 11.18 8 279657 5 29294857
Bronchospasm 25.48 11.18 32 279633 9577 29285285
Aspiration bone marrow abnormal 25.45 11.18 15 279650 100 29294762
Obsessive-compulsive disorder 25.42 11.18 6 279659 4570 29290292
Sweat gland tumour 25.37 11.18 25 279640 387 29294475
Hidradenitis 25.32 11.18 33 279632 703 29294159
Graft versus host disease in eye 25.29 11.18 20 279645 227 29294635
Synovial disorder 25.28 11.18 18 279647 172 29294690
Oesophageal stenosis 25.13 11.18 49 279616 1486 29293376
Lentigo 25.12 11.18 24 279641 357 29294505
Pachymeningitis 25.07 11.18 14 279651 83 29294779
Hypoxic-ischaemic encephalopathy 25.05 11.18 5 279660 4279 29290583
Chronic obstructive pulmonary disease 24.92 11.18 257 279408 40698 29254164
Neuroendocrine carcinoma of the skin 24.84 11.18 30 279635 590 29294272
Sudden death 24.69 11.18 61 279604 14049 29280813
Ankle deformity 24.65 11.18 19 279646 207 29294655
Chest discomfort 24.64 11.18 297 279368 45686 29249176
Gastric haemorrhage 24.61 11.18 31 279634 9266 29285596
Brain natriuretic peptide increased 24.61 11.18 5 279660 4225 29290637
Bradyphrenia 24.47 11.18 5 279660 4209 29290653
Osteolysis 24.47 11.18 49 279616 1516 29293346
Cheilitis 24.47 11.18 58 279607 2018 29292844
Mucocutaneous leishmaniasis 24.43 11.18 13 279652 69 29294793
Injection site erythema 24.41 11.18 220 279445 13736 29281126
Glycosylated haemoglobin increased 24.36 11.18 32 279633 9394 29285468
Ventricular extrasystoles 24.32 11.18 39 279626 10543 29284319
Enterovirus infection 24.30 11.18 31 279634 646 29294216
Leukopenia 24.29 11.18 689 278976 54514 29240348
Therapeutic product effect delayed 24.28 11.18 40 279625 1060 29293802
Abnormal dreams 24.21 11.18 18 279647 6902 29287960
Atrioventricular block complete 24.17 11.18 24 279641 7987 29286875
Shock 24.14 11.18 112 279553 21292 29273570
Blood loss anaemia 24.03 11.18 20 279645 7246 29287616
Acidosis 24.02 11.18 34 279631 9671 29285191
Subdural hygroma 23.94 11.18 21 279644 278 29294584
Peritonsillar abscess 23.92 11.18 22 279643 311 29294551
Extradural abscess 23.91 11.18 29 279636 573 29294289
Granulomatous pneumonitis 23.88 11.18 10 279655 27 29294835
Pruritus 23.82 11.18 884 278781 115965 29178897
Terminal state 23.79 11.18 80 279585 3414 29291448
Pyopneumothorax 23.76 11.18 12 279653 56 29294806
Altered state of consciousness 23.68 11.18 102 279563 19787 29275075
Hypophosphataemia 23.61 11.18 24 279641 7900 29286962
Flatulence 23.50 11.18 87 279578 17622 29277240
Alopecia 23.47 11.18 280 279385 18804 29276058
Nail psoriasis 23.43 11.18 12 279653 58 29294804
Pulmonary arteriopathy 23.43 11.18 13 279652 76 29294786
Medication error 23.33 11.18 112 279553 21099 29273763
Acute monocytic leukaemia 23.31 11.18 22 279643 322 29294540
Antithrombin III decreased 23.28 11.18 21 279644 289 29294573
Acute respiratory failure 23.26 11.18 150 279515 26252 29268610
Angina unstable 23.18 11.18 42 279623 10823 29284039
Granulocytopenia 23.11 11.18 14 279651 5980 29288882
Toxic leukoencephalopathy 23.03 11.18 20 279645 261 29294601
Syringe issue 22.97 11.18 4 279661 3774 29291088
Hepatic function abnormal 22.91 11.18 509 279156 38750 29256112
Ventricular hypertrophy 22.89 11.18 6 279659 4258 29290604
Meningitis listeria 22.84 11.18 23 279642 366 29294496
Hepatitis cholestatic 22.76 11.18 19 279646 6874 29287988
Terminal ileitis 22.75 11.18 14 279651 102 29294760
Hyperuricaemia 22.74 11.18 19 279646 6870 29287992
Prescribed underdose 22.73 11.18 24 279641 7762 29287100
Osteosarcoma recurrent 22.69 11.18 9 279656 20 29294842
Catatonia 22.67 11.18 7 279658 4461 29290401
Inflammatory pain 22.64 11.18 15 279650 126 29294736
Limb deformity 22.63 11.18 26 279639 484 29294378
Hepatitis B virus test positive 22.60 11.18 20 279645 268 29294594
Bacterial infection 22.59 11.18 204 279461 12744 29282118
Pemphigoid 22.55 11.18 23 279642 7558 29287304
Macule 22.50 11.18 37 279628 979 29293883
C-reactive protein decreased 22.40 11.18 47 279618 1504 29293358
Meningitis aseptic 22.40 11.18 61 279604 2315 29292547
Faecaloma 22.39 11.18 6 279659 4196 29290666
Endocarditis bacterial 22.27 11.18 33 279632 796 29294066
Pneumocystis jirovecii infection 22.24 11.18 45 279620 1403 29293459
Abdominal discomfort 22.23 11.18 602 279063 47301 29247561
Lennox-Gastaut syndrome 22.21 11.18 10 279655 34 29294828
Intestinal sepsis 22.13 11.18 24 279641 418 29294444
Human rhinovirus test positive 22.12 11.18 16 279649 157 29294705
Acute myelomonocytic leukaemia 22.10 11.18 14 279651 108 29294754
Rheumatoid vasculitis 22.01 11.18 18 279647 215 29294647
Ischaemic cardiomyopathy 21.97 11.18 13 279652 5625 29289237
Symptom recurrence 21.96 11.18 20 279645 279 29294583
Synovectomy 21.92 11.18 12 279653 68 29294794
Low density lipoprotein increased 21.92 11.18 5 279660 3899 29290963
Sepsis 21.92 11.18 1599 278066 141083 29153779
Second primary malignancy 21.92 11.18 123 279542 6582 29288280
Pyoderma gangrenosum 21.91 11.18 38 279627 1051 29293811
Leukocytosis 21.90 11.18 114 279551 21028 29273834
Paraplegia 21.86 11.18 63 279602 2471 29292391
Meningitis staphylococcal 21.84 11.18 11 279654 51 29294811
Infective myositis 21.84 11.18 9 279656 23 29294839
Parkinsonism 21.74 11.18 22 279643 7256 29287606
Physical disability 21.72 11.18 41 279624 1213 29293649
Encephalitis 21.72 11.18 119 279546 6311 29288551
Acute lymphocytic leukaemia refractory 21.66 11.18 13 279652 90 29294772
Renal cell carcinoma 21.66 11.18 95 279570 4601 29290261
Juvenile melanoma benign 21.65 11.18 12 279653 70 29294792
Hodgkin's disease 21.59 11.18 33 279632 819 29294043
Urticaria 21.55 11.18 673 278992 53987 29240875
Iron deficiency anaemia 21.47 11.18 32 279633 8910 29285952
Abdominal pain upper 21.43 11.18 427 279238 60566 29234296
Ependymoma malignant 21.40 11.18 8 279657 14 29294848
Capnocytophaga infection 21.35 11.18 11 279654 54 29294808
Blood alkaline phosphatase increased 21.32 11.18 169 279496 28237 29266625
Bronchopulmonary aspergillosis 21.29 11.18 194 279471 12150 29282712
Injection site papule 21.28 11.18 20 279645 291 29294571
Carcinoma in situ of skin 21.24 11.18 12 279653 73 29294789
Joint warmth 21.15 11.18 19 279646 260 29294602
Polyuria 21.15 11.18 23 279642 7339 29287523
Device leakage 21.15 11.18 8 279657 4487 29290375
Epstein-Barr virus test positive 21.12 11.18 25 279640 481 29294381
Listeriosis 21.10 11.18 34 279631 884 29293978
Acute pulmonary histoplasmosis 21.09 11.18 15 279650 143 29294719
Neck pain 21.07 11.18 302 279363 21145 29273717
Osteoporosis 21.06 11.18 174 279491 10595 29284267
Refusal of treatment by patient 21.03 11.18 9 279656 4685 29290177
Muscle swelling 21.01 11.18 21 279644 331 29294531
Trichosporon infection 20.94 11.18 28 279637 612 29294250
Dermatitis acneiform 20.92 11.18 13 279652 5478 29289384
Skin dystrophy 20.91 11.18 7 279658 7 29294855
Angioimmunoblastic T-cell lymphoma stage IV 20.91 11.18 7 279658 7 29294855
Swollen joint count increased 20.90 11.18 14 279651 120 29294742
Neutropenic colitis 20.86 11.18 60 279605 2351 29292511
Escherichia infection 20.75 11.18 122 279543 6642 29288220
Escherichia sepsis 20.64 11.18 83 279582 3866 29290996
Staphylococcal bacteraemia 20.64 11.18 126 279539 6953 29287909
Tuberculous pleurisy 20.61 11.18 21 279644 339 29294523
Pneumonia cytomegaloviral 20.61 11.18 64 279601 2618 29292244
Pollakiuria 20.60 11.18 86 279579 16830 29278032
No adverse event 20.58 11.18 90 279575 17388 29277474
Gout 20.58 11.18 86 279579 16825 29278037
Episcleritis 20.53 11.18 14 279651 124 29294738
Mycobacterium marinum infection 20.46 11.18 19 279646 272 29294590
Dyspnoea at rest 20.45 11.18 3 279662 3211 29291651
Meningitis chemical 20.43 11.18 11 279654 60 29294802
Anal abscess 20.37 11.18 101 279564 5150 29289712
Shoulder arthroplasty 20.36 11.18 23 279642 420 29294442
Tinea versicolour 20.35 11.18 19 279646 274 29294588
Product complaint 20.32 11.18 13 279652 5392 29289470
Circulatory collapse 20.30 11.18 99 279566 18574 29276288
Stenotrophomonas infection 20.27 11.18 48 279617 1669 29293193
Refractoriness to platelet transfusion 20.26 11.18 10 279655 44 29294818
Intestinal ischaemia 20.25 11.18 20 279645 6672 29288190
Pneumonia fungal 20.24 11.18 108 279557 5669 29289193
Blood magnesium decreased 20.24 11.18 13 279652 5381 29289481
JC virus infection 20.23 11.18 51 279614 1846 29293016
Empyema 20.15 11.18 65 279600 2714 29292148
Spondylitis 20.13 11.18 36 279629 1021 29293841
Epstein-Barr virus antigen positive 20.12 11.18 9 279656 30 29294832
Vascular access complication 20.07 11.18 17 279648 214 29294648
Dysarthria 20.05 11.18 191 279474 30720 29264142
Tongue disorder 20.04 11.18 92 279573 4544 29290318
Nocturia 20.00 11.18 30 279635 8332 29286530
Epstein-Barr virus associated lymphoma 19.95 11.18 26 279639 554 29294308
Infusion related reaction 19.94 11.18 550 279115 43336 29251526
Sinusitis 19.93 11.18 445 279220 33905 29260957
Bone marrow transplant rejection 19.92 11.18 16 279649 186 29294676
Thymus enlargement 19.91 11.18 10 279655 46 29294816
Prothrombin time prolonged 19.88 11.18 33 279632 8799 29286063
Body temperature fluctuation 19.86 11.18 43 279622 1407 29293455
Leishmaniasis 19.81 11.18 19 279646 284 29294578
Bladder transitional cell carcinoma recurrent 19.74 11.18 13 279652 108 29294754
Cerebral thrombosis 19.69 11.18 32 279633 838 29294024
Asphyxia 19.68 11.18 13 279652 5302 29289560
Steatohepatitis 19.65 11.18 19 279646 287 29294575
Herpes simplex 19.65 11.18 95 279570 4795 29290067
Metastatic bronchial carcinoma 19.63 11.18 17 279648 221 29294641
Muscle haemorrhage 19.50 11.18 4 279661 3358 29291504
Cutaneous symptom 19.48 11.18 18 279647 256 29294606
Pericarditis tuberculous 19.46 11.18 11 279654 67 29294795
Infectious thyroiditis 19.44 11.18 12 279653 88 29294774
Blood glucose fluctuation 19.43 11.18 5 279660 3592 29291270
Lipodystrophy acquired 19.43 11.18 3 279662 3091 29291771
Muscle spasticity 19.40 11.18 11 279654 4872 29289990
Nephrolithiasis 19.33 11.18 342 279323 24992 29269870
Mesenteritis 19.28 11.18 9 279656 34 29294828
Neonatal respiratory distress syndrome 19.28 11.18 6 279659 3804 29291058
Oral surgery 19.20 11.18 25 279640 532 29294330
Immune recovery uveitis 19.19 11.18 7 279658 11 29294851
Drug dependence 19.10 11.18 118 279547 20863 29273999
Hypogammaglobulinaemia 19.07 11.18 108 279557 5799 29289063
Fine motor skill dysfunction 19.01 11.18 44 279621 1507 29293355
International normalised ratio decreased 18.82 11.18 8 279657 4182 29290680
Granulomatosis with polyangiitis 18.74 11.18 32 279633 874 29293988
Ligament calcification 18.72 11.18 16 279649 204 29294658
Anaphylactic shock 18.71 11.18 64 279601 13272 29281590
Ophthalmic herpes zoster 18.64 11.18 29 279636 731 29294131
Coordination abnormal 18.54 11.18 24 279641 7090 29287772
Mucosal disorder 18.50 11.18 43 279622 1477 29293385
Varicella 18.48 11.18 42 279623 1421 29293441
Localised infection 18.46 11.18 206 279459 13610 29281252
Amyloidosis 18.44 11.18 51 279614 1953 29292909
Cerebral infarction 18.43 11.18 147 279518 24528 29270334
Steroid diabetes 18.42 11.18 46 279619 1655 29293207
Coma scale abnormal 18.40 11.18 5 279660 3464 29291398
Musculoskeletal disorder 18.39 11.18 98 279567 5142 29289720
Heavy chain disease 18.35 11.18 5 279660 0 29294862
Squamous cell carcinoma of the tongue 18.33 11.18 17 279648 243 29294619
Haemorrhagic stroke 18.30 11.18 17 279648 5839 29289023
Respiratory acidosis 18.30 11.18 9 279656 4319 29290543
Electrocardiogram QRS complex prolonged 18.22 11.18 8 279657 4102 29290760
Herpes virus infection 18.17 11.18 59 279606 2472 29292390
Meningitis 18.08 11.18 85 279580 4240 29290622
Acute coronary syndrome 18.08 11.18 58 279607 12267 29282595
Hypothyroidism 18.07 11.18 83 279582 15823 29279039
Cytopenia 18.06 11.18 157 279508 9702 29285160
Mediastinal mass 18.06 11.18 14 279651 154 29294708
Muscle twitching 18.06 11.18 30 279635 7996 29286866
Iritis 18.03 11.18 38 279627 1220 29293642
Gastrointestinal inflammation 18.00 11.18 66 279599 2942 29291920
Pseudomonal sepsis 17.98 11.18 65 279600 2877 29291985
Legionella infection 17.97 11.18 22 279643 439 29294423
Leukodystrophy 17.92 11.18 6 279659 6 29294856
Morphoea 17.91 11.18 14 279651 156 29294706
Product administration error 17.90 11.18 72 279593 14238 29280624
Splenic infection fungal 17.89 11.18 11 279654 80 29294782
Thirst 17.86 11.18 21 279644 6470 29288392
Large intestinal stenosis 17.84 11.18 40 279625 1341 29293521
Cystitis escherichia 17.84 11.18 14 279651 157 29294705
Eye infection toxoplasmal 17.82 11.18 15 279650 187 29294675
Monoclonal B-cell lymphocytosis 17.81 11.18 8 279657 27 29294835
Lip swelling 17.79 11.18 59 279606 12351 29282511
Osteosarcoma 17.76 11.18 15 279650 188 29294674
Tooth abscess 17.75 11.18 94 279571 4920 29289942
Atrioventricular block 17.74 11.18 24 279641 6958 29287904
Stem cell transplant 17.73 11.18 50 279615 1937 29292925
Micrognathia 17.70 11.18 18 279647 290 29294572
Cushingoid 17.65 11.18 57 279608 2381 29292481
Exostosis 17.63 11.18 74 279591 3515 29291347
Strongyloidiasis 17.61 11.18 55 279610 2257 29292605
Face oedema 17.57 11.18 45 279620 10238 29284624
Post procedural infection 17.56 11.18 84 279581 4221 29290641
Cardiac murmur 17.55 11.18 22 279643 6591 29288271
Cystitis viral 17.54 11.18 23 279642 493 29294369
Systemic candida 17.49 11.18 62 279603 2718 29292144
Alveolitis 17.47 11.18 43 279622 1533 29293329
Arthroscopy 17.46 11.18 11 279654 84 29294778
Dysphonia 17.45 11.18 108 279557 19088 29275774
Haemodynamic instability 17.41 11.18 31 279634 8042 29286820
Temporal lobe epilepsy 17.34 11.18 14 279651 164 29294698
Granuloma 17.29 11.18 57 279608 2407 29292455
Bursitis infective staphylococcal 17.23 11.18 7 279658 17 29294845
Glottis carcinoma 17.23 11.18 7 279658 17 29294845
Nasal cavity cancer 17.22 11.18 13 279652 137 29294725
Lung neoplasm 17.21 11.18 84 279581 4256 29290606
Ischaemic stroke 17.20 11.18 85 279580 15892 29278970
Prostatic specific antigen increased 17.15 11.18 61 279604 12503 29282359
Body temperature decreased 17.09 11.18 165 279500 10499 29284363
Iris adhesions 17.07 11.18 16 279649 232 29294630
Bone sarcoma 17.05 11.18 10 279655 66 29294796
Meningoencephalitis herpetic 17.02 11.18 28 279637 741 29294121
Dysplastic naevus syndrome 17.02 11.18 6 279659 8 29294854
Silicosis 16.95 11.18 7 279658 18 29294844
Sinusitis fungal 16.93 11.18 20 279645 384 29294478
Somnambulism 16.93 11.18 3 279662 2795 29292067
Neoplasm recurrence 16.91 11.18 49 279616 1928 29292934
Urine output decreased 16.91 11.18 39 279626 9199 29285663
Precursor T-lymphoblastic lymphoma/leukaemia 16.88 11.18 9 279656 48 29294814
Asthma 16.87 11.18 222 279443 33627 29261235
Pharyngeal inflammation 16.85 11.18 18 279647 308 29294554
Extranodal marginal zone B-cell lymphoma (MALT type) 16.80 11.18 14 279651 172 29294690
Phototherapy 16.79 11.18 8 279657 32 29294830
Protein urine present 16.69 11.18 12 279653 4682 29290180
Cerebrosclerosis 16.69 11.18 7 279658 19 29294843
Visual acuity reduced 16.68 11.18 78 279587 14798 29280064
Bone marrow oedema 16.66 11.18 22 279643 475 29294387
Central nervous system infection 16.66 11.18 23 279642 519 29294343
Chronic myeloid leukaemia 16.65 11.18 49 279616 1945 29292917
Electrocardiogram ST segment elevation 16.62 11.18 11 279654 4481 29290381
Purulent pericarditis 16.61 11.18 6 279659 9 29294853
Myocarditis 16.46 11.18 51 279614 10905 29283957
Hepatic candidiasis 16.44 11.18 9 279656 51 29294811
Toxoplasmosis 16.44 11.18 35 279630 1132 29293730
Prescribed overdose 16.43 11.18 36 279629 8647 29286215
Intestinal stenosis 16.35 11.18 47 279618 1841 29293021
Psychomotor retardation 16.34 11.18 4 279661 2972 29291890
Ketoacidosis 16.27 11.18 7 279658 3632 29291230
Swelling face 16.25 11.18 119 279546 20231 29274631
International normalised ratio abnormal 16.23 11.18 4 279661 2959 29291903
Secondary amyloidosis 16.23 11.18 10 279655 73 29294789
West Nile viral infection 16.22 11.18 25 279640 625 29294237
Scab 16.22 11.18 77 279588 3857 29291005
Stomatitis haemorrhagic 16.17 11.18 9 279656 53 29294809
Q fever 16.17 11.18 12 279653 123 29294739
Septic shock 16.17 11.18 735 278930 61825 29233037
Autoimmune lymphoproliferative syndrome 16.05 11.18 13 279652 153 29294709
Thyroid cancer 16.00 11.18 38 279627 1324 29293538
Palmoplantar pustulosis 15.98 11.18 11 279654 99 29294763
Transplant rejection 15.98 11.18 40 279625 9172 29285690
Taste disorder 15.98 11.18 13 279652 4763 29290099
Thrombosis in device 15.98 11.18 5 279660 3159 29291703
Lymphopenia 15.97 11.18 197 279468 13336 29281526
Salivary gland cancer 15.92 11.18 16 279649 254 29294608
Electrolyte imbalance 15.89 11.18 54 279611 11220 29283642
Tonsillar ulcer 15.78 11.18 13 279652 157 29294705
Bronchiolitis obliterans syndrome 15.78 11.18 13 279652 157 29294705
Diffuse large B-cell lymphoma stage III 15.77 11.18 9 279656 56 29294806
Antisynthetase syndrome 15.77 11.18 9 279656 56 29294806
Tonsillar disorder 15.72 11.18 11 279654 102 29294760
Muscle abscess 15.71 11.18 21 279644 459 29294403
Bundle branch block left 15.70 11.18 16 279649 5261 29289601
Meningitis enterococcal 15.70 11.18 10 279655 78 29294784
Rectal haemorrhage 15.65 11.18 231 279434 34318 29260544
Bladder neoplasm 15.65 11.18 36 279629 1228 29293634
Gynaecomastia 15.60 11.18 34 279631 8183 29286679
Cauda equina syndrome 15.57 11.18 19 279646 378 29294484
Keratitis 15.54 11.18 35 279630 1177 29293685
Crohn's disease 15.53 11.18 63 279602 2946 29291916
Adactyly 15.52 11.18 9 279656 58 29294804
Alcohol abuse 15.51 11.18 11 279654 4322 29290540
Osteomyelitis 15.51 11.18 198 279467 13511 29281351
Hot flush 15.50 11.18 80 279585 14790 29280072
Mental disorder 15.47 11.18 66 279599 12839 29282023
Erythema multiforme 15.44 11.18 31 279634 7686 29287176
Blood testosterone decreased 15.40 11.18 9 279656 3921 29290941
Pharyngitis 15.40 11.18 116 279549 6867 29287995
Infective tenosynovitis 15.39 11.18 9 279656 59 29294803
B-cell lymphoma stage IV 15.39 11.18 9 279656 59 29294803
T-cell type acute leukaemia 15.39 11.18 10 279655 81 29294781
Anal inflammation 15.37 11.18 17 279648 303 29294559
Mucosal ulceration 15.34 11.18 29 279636 859 29294003
Pneumatosis intestinalis 15.30 11.18 65 279600 3104 29291758
Mucosal necrosis 15.27 11.18 9 279656 60 29294802
Malignant melanoma stage I 15.19 11.18 10 279655 83 29294779
Myocardial ischaemia 15.19 11.18 89 279576 15939 29278923
Anaplastic large cell lymphoma T- and null-cell types 15.19 11.18 10 279655 83 29294779
Systemic lupus erythematosus 15.10 11.18 56 279609 2510 29292352
Bursa disorder 15.05 11.18 14 279651 201 29294661
Cerebral toxoplasmosis 15.03 11.18 38 279627 1378 29293484
Blood culture positive 14.98 11.18 84 279581 4493 29290369
Tender joint count increased 14.95 11.18 8 279657 43 29294819
Infective aneurysm 14.94 11.18 21 279644 482 29294380
Bladder neck operation 14.93 11.18 5 279660 5 29294857
Osteomyelitis salmonella 14.89 11.18 7 279658 27 29294835
Injection site rash 14.87 11.18 70 279595 3494 29291368
White matter lesion 14.84 11.18 24 279641 626 29294236
Bradykinesia 14.83 11.18 7 279658 3440 29291422
Ventricular arrhythmia 14.83 11.18 13 279652 4591 29290271
Rheumatic disorder 14.81 11.18 21 279644 486 29294376
Organising pneumonia 14.81 11.18 90 279575 4958 29289904
Small fibre neuropathy 14.81 11.18 8 279657 44 29294818
Ammonia increased 14.74 11.18 10 279655 4021 29290841
Sudden cardiac death 14.72 11.18 6 279659 3216 29291646
Joint abscess 14.72 11.18 11 279654 114 29294748
Anal squamous cell carcinoma 14.69 11.18 9 279656 65 29294797
Fear-related avoidance of activities 14.68 11.18 4 279661 0 29294862
Oral toxicity 14.68 11.18 4 279661 0 29294862
Actinomycosis 14.67 11.18 18 279647 360 29294502
Hepatitis B reactivation 14.65 11.18 65 279600 3164 29291698
Hemiparesis 14.64 11.18 205 279460 14281 29280581
Hypersensitivity pneumonitis 14.63 11.18 36 279629 1283 29293579
Subcutaneous abscess 14.63 11.18 68 279597 3376 29291486
Defaecation urgency 14.63 11.18 43 279622 1706 29293156
Demyelinating polyneuropathy 14.62 11.18 33 279632 1111 29293751
Mood swings 14.62 11.18 29 279636 7222 29287640
Injection site reaction 14.58 11.18 166 279499 11022 29283840
Small cell lung cancer 14.58 11.18 43 279622 1709 29293153
Blood cholesterol increased 14.57 11.18 87 279578 15508 29279354
Cartilage injury 14.56 11.18 21 279644 494 29294368
Adenoviral hepatitis 14.56 11.18 14 279651 210 29294652
Cutaneous tuberculosis 14.53 11.18 10 279655 90 29294772
Azotaemia 14.52 11.18 13 279652 4544 29290318
Stupor 14.47 11.18 4 279661 2740 29292122
Gastrooesophageal reflux disease 14.47 11.18 210 279455 31286 29263576
Bladder cancer 14.46 11.18 153 279512 9974 29284888
Hypotonia 14.44 11.18 27 279638 6875 29287987
Neutrophil count decreased 14.41 11.18 308 279357 43259 29251603
Stress ulcer 14.36 11.18 9 279656 68 29294794
Blood cholesterol abnormal 14.31 11.18 38 279627 1420 29293442
Panniculitis 14.27 11.18 34 279631 1187 29293675
Superior mesenteric artery syndrome 14.25 11.18 9 279656 69 29294793
Haematopoietic neoplasm 14.25 11.18 8 279657 48 29294814
Post lumbar puncture syndrome 14.23 11.18 13 279652 182 29294680
Hepatic failure 14.17 11.18 211 279454 31301 29263561
Total lung capacity decreased 14.16 11.18 22 279643 554 29294308
Fusarium infection 14.15 11.18 30 279635 967 29293895
Ossicle disorder 14.15 11.18 7 279658 31 29294831
Nephrogenic systemic fibrosis 14.12 11.18 10 279655 3932 29290930
Hyperthermia 14.10 11.18 44 279621 9386 29285476
Quadriplegia 14.05 11.18 39 279626 1497 29293365
Echinococciasis 14.04 11.18 5 279660 7 29294855
CNS ventriculitis 14.04 11.18 14 279651 220 29294642
Splenic lesion 14.04 11.18 11 279654 123 29294739
Scedosporium infection 14.02 11.18 26 279639 759 29294103
Bronchoalveolar lavage abnormal 13.94 11.18 9 279656 72 29294790
Intestinal atresia 13.94 11.18 9 279656 72 29294790
Cardiomegaly 13.87 11.18 75 279590 13701 29281161
Hepatitis E 13.85 11.18 41 279624 1633 29293229
Diffuse large B-cell lymphoma stage IV 13.84 11.18 14 279651 224 29294638
Urinary incontinence 13.83 11.18 95 279570 16386 29278476
Inflammatory myofibroblastic tumour 13.83 11.18 11 279654 126 29294736
Emotional distress 13.79 11.18 76 279589 13819 29281043
Gallbladder oedema 13.79 11.18 13 279652 190 29294672
Hepatosplenic candidiasis 13.79 11.18 13 279652 190 29294672
Acute pulmonary oedema 13.76 11.18 27 279638 6752 29288110
Inadequate analgesia 13.75 11.18 4 279661 2650 29292212
Encephalitis viral 13.75 11.18 32 279633 1100 29293762
Cerebral fungal infection 13.74 11.18 14 279651 226 29294636
Lower respiratory tract infection 13.74 11.18 338 279327 26164 29268698
Drug level below therapeutic 13.73 11.18 78 279587 4193 29290669
Abscess intestinal 13.70 11.18 37 279628 1397 29293465
Faecal calprotectin abnormal 13.68 11.18 13 279652 192 29294670
Oesophageal squamous cell carcinoma 13.67 11.18 17 279648 345 29294517
Cardiac failure acute 13.66 11.18 43 279622 9149 29285713
Conus medullaris syndrome 13.65 11.18 5 279660 8 29294854
Ear canal stenosis 13.65 11.18 5 279660 8 29294854
Encephalitis brain stem 13.64 11.18 9 279656 75 29294787
Encephalitis Japanese B 13.64 11.18 6 279659 19 29294843
Wrist surgery 13.62 11.18 11 279654 129 29294733
Mitral valve incompetence 13.59 11.18 72 279593 13221 29281641
Ascites 13.58 11.18 254 279411 36365 29258497
Blood urine present 13.56 11.18 47 279618 9708 29285154
Graft versus host disease in lung 13.54 11.18 20 279645 481 29294381
Hypersomnia 13.52 11.18 54 279611 10700 29284162
Atypical mycobacterial infection 13.51 11.18 24 279641 677 29294185
Intracranial pressure increased 13.50 11.18 67 279598 3418 29291444
Nail dystrophy 13.49 11.18 12 279653 162 29294700
Diverticular perforation 13.48 11.18 60 279605 2924 29291938
Pulmonary congestion 13.48 11.18 66 279599 12370 29282492
Nervousness 13.45 11.18 58 279607 11248 29283614
Chronic actinic dermatitis 13.41 11.18 6 279659 20 29294842
Suspected product quality issue 13.41 11.18 11 279654 132 29294730
Body height decreased 13.38 11.18 8 279657 3442 29291420
Meningitis viral 13.37 11.18 26 279639 787 29294075
Communication disorder 13.34 11.18 3 279662 2362 29292500
Diffuse idiopathic skeletal hyperostosis 13.33 11.18 7 279658 36 29294826
Chills 13.29 11.18 545 279120 70755 29224107
CSF myelin basic protein increased 13.29 11.18 5 279660 9 29294853
Musculoskeletal deformity 13.29 11.18 5 279660 9 29294853
Eructation 13.28 11.18 11 279654 3995 29290867
Cyanosis 13.28 11.18 58 279607 11209 29283653
Post inflammatory pigmentation change 13.27 11.18 14 279651 236 29294626
Transfusion 13.21 11.18 31 279634 7267 29287595
Herpes zoster oticus 13.20 11.18 10 279655 106 29294756
Pain of skin 13.15 11.18 71 279594 3744 29291118
Testicular seminoma (pure) 13.14 11.18 8 279657 57 29294805
Pneumonitis chemical 13.08 11.18 11 279654 137 29294725
Spinal cord disorder 13.05 11.18 24 279641 696 29294166
Gastroenteritis Escherichia coli 13.03 11.18 12 279653 170 29294692
Furuncle 13.00 11.18 59 279606 2900 29291962
Dialysis 12.99 11.18 51 279614 10157 29284705
HLA-B*27 positive 12.99 11.18 6 279659 22 29294840
Abscess sterile 12.99 11.18 6 279659 22 29294840
Tonsillitis 12.99 11.18 45 279620 1950 29292912
Crystal nephropathy 12.98 11.18 17 279648 364 29294498
Meningitis noninfective 12.95 11.18 5 279660 10 29294852
Solar urticaria 12.95 11.18 5 279660 10 29294852
Folate deficiency 12.94 11.18 31 279634 1086 29293776
Mycobacterium avium complex infection 12.92 11.18 49 279616 2220 29292642
Burkitt's lymphoma 12.90 11.18 10 279655 110 29294752
Amyotrophic lateral sclerosis 12.87 11.18 27 279638 864 29293998
Staphylococcal infection 12.87 11.18 365 279300 28875 29265987
Cholangitis 12.87 11.18 33 279632 7504 29287358
Euphoric mood 12.86 11.18 16 279649 4809 29290053
Anaemia megaloblastic 12.86 11.18 12 279653 173 29294689
C-reactive protein 12.82 11.18 10 279655 111 29294751
Laboratory test abnormal 12.82 11.18 110 279555 18075 29276787
Cerebral haematoma 12.81 11.18 13 279652 4283 29290579
Cryptococcal fungaemia 12.81 11.18 9 279656 84 29294778
Nail pitting 12.80 11.18 13 279652 209 29294653
Spinal cord abscess 12.80 11.18 13 279652 209 29294653
Mucosal infection 12.80 11.18 13 279652 209 29294653
Double stranded DNA antibody 12.79 11.18 6 279659 23 29294839
Investigation abnormal 12.78 11.18 18 279647 414 29294448
Oesophageal adenocarcinoma 12.78 11.18 25 279640 760 29294102
Pseudolymphoma 12.78 11.18 20 279645 507 29294355
Loss of libido 12.78 11.18 3 279662 2293 29292569
Pancreatic neoplasm 12.75 11.18 26 279639 815 29294047
Chronic graft versus host disease in liver 12.71 11.18 16 279649 329 29294533
Hepatosplenomegaly 12.69 11.18 69 279596 3648 29291214
Glomerular filtration rate decreased 12.67 11.18 59 279606 11207 29283655
Extrapulmonary tuberculosis 12.64 11.18 9 279656 86 29294776
Sleep disorder due to a general medical condition 12.62 11.18 7 279658 3139 29291723
Haemangioma of liver 12.62 11.18 19 279646 465 29294397
Herpes simplex encephalitis 12.62 11.18 15 279650 290 29294572
Iridocyclitis 12.62 11.18 36 279629 1404 29293458
Ileus 12.59 11.18 82 279583 14320 29280542
Spinal cord oedema 12.58 11.18 12 279653 178 29294684
Lung abscess 12.58 11.18 50 279615 2316 29292546
Escherichia bacteraemia 12.56 11.18 57 279608 2801 29292061
Dermatitis psoriasiform 12.56 11.18 31 279634 1107 29293755
Coronary arterial stent insertion 12.55 11.18 11 279654 3886 29290976
Coccidioidomycosis 12.55 11.18 22 279643 614 29294248
Pericardial haemorrhage 12.54 11.18 6 279659 2925 29291937
Acanthosis 12.54 11.18 10 279655 115 29294747
Cardiomyopathy 12.52 11.18 85 279580 14702 29280160
Muscle oedema 12.52 11.18 11 279654 146 29294716
Skin infection 12.52 11.18 105 279560 6422 29288440
Left ventricular hypertrophy 12.51 11.18 28 279637 6675 29288187
Candida infection 12.51 11.18 208 279457 15017 29279845
Pleomorphic malignant fibrous histiocytoma 12.47 11.18 4 279661 3 29294859
Personality change due to a general medical condition 12.47 11.18 7 279658 42 29294820
Blood beta-D-glucan increased 12.46 11.18 17 279648 379 29294483
Vitreous floaters 12.44 11.18 7 279658 3114 29291748
Viral mutation identified 12.44 11.18 4 279661 2484 29292378
Radial nerve palsy 12.39 11.18 8 279657 64 29294798
Antinuclear antibody positive 12.39 11.18 34 279631 1296 29293566
Blood glucose abnormal 12.39 11.18 18 279647 5065 29289797
Vasculitis 12.38 11.18 122 279543 7806 29287056
Myeloid leukaemia 12.38 11.18 16 279649 338 29294524
Raoultella ornithinolytica infection 12.35 11.18 5 279660 12 29294850
Injection site warmth 12.33 11.18 42 279623 1804 29293058
VIth nerve paralysis 12.33 11.18 24 279641 727 29294135
Palindromic rheumatism 12.32 11.18 12 279653 183 29294679
Intestinal fibrosis 12.31 11.18 9 279656 90 29294772
Thyroid gland abscess 12.29 11.18 8 279657 65 29294797
Pneumoconiosis 12.28 11.18 13 279652 220 29294642
Ankle operation 12.28 11.18 13 279652 220 29294642
Toxic epidermal necrolysis 12.27 11.18 111 279554 18042 29276820
Food intolerance 12.27 11.18 30 279635 1065 29293797
Adenoviral haemorrhagic cystitis 12.23 11.18 17 279648 386 29294476
Mediastinal abscess 12.23 11.18 6 279659 26 29294836
Abscess bacterial 12.16 11.18 11 279654 152 29294710
Nocardiosis 12.15 11.18 62 279603 3198 29291664
Gastric mucosal hypertrophy 12.14 11.18 9 279656 92 29294770
Knee operation 12.13 11.18 36 279629 1436 29293426
Elbow operation 12.12 11.18 10 279655 121 29294741
Impaired quality of life 12.09 11.18 53 279612 2566 29292296
Hepatitis infectious mononucleosis 12.08 11.18 7 279658 45 29294817
Impaired gastric emptying 12.08 11.18 7 279658 3063 29291799
Purulent discharge 12.08 11.18 52 279613 2498 29292364
Ewing's sarcoma 12.07 11.18 5 279660 13 29294849
Metastatic neoplasm 12.07 11.18 54 279611 2638 29292224
Blood pressure diastolic abnormal 12.06 11.18 52 279613 2499 29292363
Joint noise 12.06 11.18 20 279645 533 29294329
Lymphocytic leukaemia 12.04 11.18 11 279654 154 29294708
Oxygen saturation decreased 12.03 11.18 328 279337 44609 29250253
Hallucinations, mixed 12.01 11.18 4 279661 2429 29292433
Herpes ophthalmic 12.00 11.18 18 279647 439 29294423
Conjunctival haemorrhage 11.99 11.18 5 279660 2643 29292219
Adverse reaction 11.94 11.18 55 279610 2720 29292142
Cavernous sinus thrombosis 11.93 11.18 11 279654 156 29294706
Cyst rupture 11.90 11.18 8 279657 69 29294793
Hyperlipidaemia 11.88 11.18 70 279595 12520 29282342
Parakeratosis 11.86 11.18 10 279655 125 29294737
Tuberculosis liver 11.84 11.18 7 279658 47 29294815
Viral vasculitis 11.81 11.18 8 279657 70 29294792
Ocular hypertension 11.76 11.18 23 279642 699 29294163
Muscle enzyme increased 11.74 11.18 13 279652 232 29294630
Pulmonary air leakage 11.73 11.18 10 279655 127 29294735
Nail injury 11.72 11.18 6 279659 29 29294833
Inflammatory pseudotumour 11.72 11.18 6 279659 29 29294833
Poikiloderma 11.71 11.18 11 279654 160 29294702
Mydriasis 11.70 11.18 25 279640 6060 29288802
Injection site pruritus 11.70 11.18 95 279570 5754 29289108
Vascular stent thrombosis 11.70 11.18 5 279660 2605 29292257
Pulmonary nocardiosis 11.69 11.18 20 279645 547 29294315
Disseminated aspergillosis 11.66 11.18 17 279648 404 29294458
Activated partial thromboplastin time prolonged 11.66 11.18 36 279629 7706 29287156
Small for dates baby 11.65 11.18 10 279655 3569 29291293
Otitis media acute 11.65 11.18 18 279647 451 29294411
Sinus tachycardia 11.61 11.18 89 279576 14980 29279882
Therapy change 11.61 11.18 5 279660 2593 29292269
Xyphoid retraction 11.60 11.18 11 279654 162 29294700
Increased appetite 11.59 11.18 25 279640 6039 29288823
Immobile 11.58 11.18 47 279618 2198 29292664
Rocky mountain spotted fever 11.56 11.18 5 279660 15 29294847
Superficial spreading melanoma stage unspecified 11.55 11.18 11 279654 163 29294699
Exposure to communicable disease 11.54 11.18 10 279655 130 29294732
Neurological decompensation 11.50 11.18 50 279615 2412 29292450
Oral pustule 11.48 11.18 13 279652 238 29294624
Myositis 11.48 11.18 54 279611 10229 29284633
Joint injury 11.47 11.18 108 279557 6825 29288037
Synostosis 11.46 11.18 9 279656 101 29294761
Bacterial sepsis 11.45 11.18 80 279585 4623 29290239
Rheumatoid factor 11.45 11.18 8 279657 74 29294788
Cell marker increased 11.45 11.18 17 279648 411 29294451
Hypercapnia 11.43 11.18 11 279654 3715 29291147
Gastric ulcer haemorrhage 11.40 11.18 18 279647 4896 29289966
Rash pruritic 11.39 11.18 146 279519 22217 29272645
Arteriosclerosis 11.37 11.18 54 279611 10202 29284660
Arteriospasm coronary 11.36 11.18 5 279660 2560 29292302
Prerenal failure 11.35 11.18 40 279625 1748 29293114
Cancer pain 11.34 11.18 4 279661 2343 29292519
Joint space narrowing 11.27 11.18 8 279657 76 29294786
Hepatitis acute 11.26 11.18 28 279637 6434 29288428
Follicular lymphoma 11.25 11.18 6 279659 32 29294830
Psoriasis area severity index increased 11.25 11.18 6 279659 32 29294830
Human herpesvirus 6 infection 11.25 11.18 41 279624 1822 29293040
Neoplasm progression 11.23 11.18 117 279548 18495 29276367
Low birth weight baby 11.23 11.18 29 279636 6579 29288283
Dry skin 11.20 11.18 154 279511 23153 29271709

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 12793.26 11.11 31410 813173 808837 62845312
Drug intolerance 4919.08 11.11 8818 835765 179174 63474975
Joint swelling 3241.20 11.11 8061 836522 207321 63446828
Treatment failure 3132.80 11.11 5543 839040 111273 63542876
Arthralgia 2751.99 11.11 12261 832322 429999 63224150
Completed suicide 2634.59 11.11 64 844519 224350 63429799
Death 2617.01 11.11 1542 843041 481163 63172986
Drug hypersensitivity 2508.45 11.11 7821 836762 229994 63424155
Rheumatoid arthritis 2235.29 11.11 5923 838660 158371 63495778
Therapeutic product effect incomplete 2219.99 11.11 4465 840118 99017 63555132
Synovitis 2045.35 11.11 4208 840375 94882 63559267
Contraindicated product administered 1719.04 11.11 4130 840453 103699 63550450
Musculoskeletal stiffness 1622.43 11.11 4390 840193 118816 63535333
Therapeutic product effect decreased 1549.84 11.11 4141 840442 111210 63542939
Drug abuse 1427.63 11.11 74 844509 132300 63521849
Lymphoproliferative disorder 1409.53 11.11 862 843721 4241 63649908
Psoriasis 1316.16 11.11 2904 841679 68799 63585350
Arthropathy 1286.32 11.11 3993 840590 116974 63537175
Hypotension 1217.18 11.11 1945 842638 379029 63275120
Psoriatic arthropathy 1152.42 11.11 2049 842534 41232 63612917
Acute kidney injury 1146.57 11.11 2624 841959 446616 63207533
Dyspnoea 1013.64 11.11 5413 839170 713261 62940888
Pain 977.25 11.11 11303 833280 542208 63111941
Liver function test increased 966.94 11.11 1574 843009 29396 63624753
Arthritis 940.49 11.11 2820 841763 80994 63573155
Constipation 932.56 11.11 976 843607 228361 63425788
Cardiac arrest 858.29 11.11 474 844109 153590 63500559
Bradycardia 845.03 11.11 249 844334 117970 63536179
Dehydration 844.16 11.11 956 843627 215807 63438342
Hyperkalaemia 837.55 11.11 155 844428 100974 63553175
Intentional overdose 826.93 11.11 102 844481 89842 63564307
C-reactive protein abnormal 813.17 11.11 1406 843177 27641 63626508
Hyponatraemia 796.91 11.11 477 844106 147862 63506287
Alopecia 791.92 11.11 4268 840315 161422 63492727
Rhabdomyolysis 769.53 11.11 136 844447 91590 63562559
Acute graft versus host disease 715.45 11.11 731 843852 8353 63645796
Pancytopenia 710.98 11.11 3730 840853 139579 63514570
Cardiac failure congestive 701.23 11.11 420 844163 130160 63523989
Mucosal inflammation 696.55 11.11 2100 842483 60484 63593665
Somnolence 696.36 11.11 991 843592 202654 63451495
Overdose 682.85 11.11 649 843934 158917 63495232
Injection site pain 679.80 11.11 3077 841506 108331 63545818
Cardio-respiratory arrest 678.47 11.11 221 844362 98172 63555977
Anaemia 674.30 11.11 2614 841969 376066 63278083
Red blood cell sedimentation rate abnormal 668.54 11.11 941 843642 15365 63638784
Red blood cell sedimentation rate increased 664.44 11.11 1344 843239 29891 63624258
Electrocardiogram QT prolonged 661.66 11.11 120 844463 79328 63574821
Hepatic enzyme increased 656.17 11.11 3399 841184 126544 63527605
Mouth ulceration 652.42 11.11 1364 843219 31080 63623069
Dizziness 648.11 11.11 3163 841420 427000 63227149
International normalised ratio increased 639.32 11.11 129 844454 79038 63575111
Drug interaction 633.38 11.11 2517 842066 359566 63294583
Confusional state 624.00 11.11 1577 843006 259567 63394582
Infection 622.35 11.11 4350 840233 180530 63473619
Swelling 603.67 11.11 3877 840706 156341 63497808
C-reactive protein increased 596.76 11.11 2645 841938 92264 63561885
Toxicity to various agents 595.35 11.11 2592 841991 360921 63293228
Syncope 590.08 11.11 717 843866 156918 63497231
Pain in extremity 587.85 11.11 6310 838273 296775 63357374
Peripheral swelling 567.97 11.11 4679 839904 204474 63449675
Hypoglycaemia 555.98 11.11 240 844343 89652 63564497
Gastrointestinal disorder 534.73 11.11 2461 842122 87248 63566901
Decreased appetite 530.83 11.11 1895 842688 279394 63374755
Stomatitis 529.86 11.11 2833 841750 106772 63547377
Fall 506.50 11.11 3288 841295 413538 63240611
Hallucination 504.41 11.11 162 844421 72626 63581523
Agitation 502.00 11.11 265 844318 88102 63566047
Leukoencephalopathy 499.17 11.11 533 844050 6434 63647715
Nasopharyngitis 496.08 11.11 4318 840265 191755 63462394
Inflammation 492.06 11.11 1924 842659 63376 63590773
Pneumocystis jirovecii pneumonia 487.41 11.11 1102 843481 26532 63627617
Loss of personal independence in daily activities 481.20 11.11 2053 842530 70401 63583748
Bone erosion 481.07 11.11 673 843910 10922 63643227
Depressed level of consciousness 479.39 11.11 233 844350 81203 63572946
Gastrointestinal haemorrhage 477.20 11.11 619 843964 131693 63522456
Abdominal discomfort 476.85 11.11 4045 840538 178277 63475872
Tremor 471.11 11.11 758 843825 147472 63506677
Joint stiffness 468.32 11.11 1150 843433 29254 63624895
Chronic graft versus host disease 465.38 11.11 489 844094 5787 63648362
Hypokalaemia 464.10 11.11 547 844036 121356 63532793
Malignant neoplasm progression 463.27 11.11 476 844107 112395 63541754
Condition aggravated 458.74 11.11 7132 837451 365294 63288855
Suicide attempt 456.22 11.11 179 844404 70828 63583321
Mobility decreased 449.59 11.11 2269 842314 83571 63570578
Diffuse large B-cell lymphoma 448.79 11.11 614 843969 9747 63644402
Asthenia 445.91 11.11 3529 841054 424515 63229634
Lactic acidosis 444.87 11.11 126 844457 61284 63592865
Osteoarthritis 434.07 11.11 1812 842771 61524 63592625
Rheumatoid factor positive 430.54 11.11 1216 843367 33722 63620427
Sedation 426.21 11.11 30 844553 41432 63612717
Diarrhoea 425.23 11.11 6785 837798 715919 62938230
Atrial fibrillation 416.30 11.11 1023 843560 170066 63484083
Coma 414.02 11.11 324 844259 87291 63566858
Multiple sclerosis relapse 413.64 11.11 33 844550 41102 63613047
Hand deformity 413.24 11.11 1774 842809 60997 63593152
Respiratory arrest 406.18 11.11 97 844486 52888 63601261
Haemoglobin decreased 405.59 11.11 1259 843324 193804 63460345
Metabolic acidosis 404.20 11.11 212 844371 70746 63583403
Rheumatoid nodule 401.64 11.11 648 843935 12003 63642146
Epstein-Barr virus infection 399.67 11.11 642 843941 11846 63642303
Therapeutic response decreased 398.30 11.11 1544 843039 50644 63603505
Sinusitis 395.49 11.11 3264 841319 142664 63511485
Product use issue 393.43 11.11 3360 841223 148355 63505794
Epstein-Barr virus associated lymphoproliferative disorder 392.05 11.11 326 844257 2793 63651356
Oedema peripheral 387.85 11.11 1430 843153 208887 63445262
Loss of consciousness 376.13 11.11 868 843715 147497 63506652
Nodule 375.43 11.11 767 843816 17180 63636969
Tuberculosis 373.91 11.11 638 843945 12400 63641749
Drug clearance decreased 372.02 11.11 294 844289 2325 63651824
Foot deformity 368.79 11.11 725 843858 15779 63638370
Anxiety 362.52 11.11 1395 843188 201254 63452895
Herpes zoster 361.85 11.11 2016 842567 77171 63576978
Drug reaction with eosinophilia and systemic symptoms 359.45 11.11 130 844453 54087 63600062
Pulmonary fibrosis 346.00 11.11 1017 843566 28861 63625288
Cardiac failure 344.84 11.11 763 843820 131610 63522539
Blood glucose increased 342.18 11.11 470 844113 97603 63556546
Injection site erythema 342.01 11.11 1830 842753 68970 63585179
Tachycardia 339.59 11.11 926 843657 148653 63505496
Sopor 338.28 11.11 11 844572 29650 63624499
Injection site bruising 335.00 11.11 1144 843439 35229 63618920
Orthostatic hypotension 334.66 11.11 98 844485 46640 63607509
Musculoskeletal pain 333.91 11.11 2012 842571 79282 63574867
Serotonin syndrome 325.59 11.11 60 844523 39222 63614927
Epstein Barr virus positive mucocutaneous ulcer 321.77 11.11 165 844418 532 63653617
Aggression 314.84 11.11 106 844477 46126 63608023
Injection site reaction 312.67 11.11 1326 843257 45338 63608811
Systemic lupus erythematosus 312.50 11.11 1911 842672 75701 63578448
Blood creatine phosphokinase increased 309.12 11.11 192 844391 58366 63595783
Platelet count decreased 306.04 11.11 1145 843438 166566 63487583
Balance disorder 303.17 11.11 392 844191 83534 63570615
Knee arthroplasty 302.19 11.11 908 843675 26091 63628058
Myelopathy 300.67 11.11 313 844270 3661 63650488
Joint range of motion decreased 297.20 11.11 731 843852 18612 63635537
Angiocentric lymphoma 296.29 11.11 164 844419 643 63653506
Ankylosing spondylitis 292.31 11.11 444 844139 7790 63646359
Acute graft versus host disease in skin 292.03 11.11 403 844180 6452 63647697
Pneumonia aspiration 291.80 11.11 210 844373 59061 63595088
Cerebrovascular accident 290.14 11.11 882 843701 136701 63517448
Chest pain 289.35 11.11 1855 842728 234125 63420024
Neuroleptic malignant syndrome 286.03 11.11 9 844574 24987 63629162
Graft versus host disease 282.65 11.11 585 843998 13228 63640921
Posterior reversible encephalopathy syndrome 282.08 11.11 798 843785 22148 63632001
Hospitalisation 277.13 11.11 346 844237 74861 63579288
Grip strength decreased 275.35 11.11 526 844057 11198 63642951
Seizure 272.64 11.11 1190 843393 165702 63488447
Unresponsive to stimuli 270.50 11.11 162 844421 50231 63603918
Acute myocardial infarction 267.24 11.11 311 844272 69407 63584742
Lower respiratory tract infection 266.86 11.11 2136 842447 92478 63561671
Intentional self-injury 266.72 11.11 33 844550 29011 63625138
Fluid retention 262.41 11.11 236 844347 59370 63594779
Finger deformity 258.08 11.11 329 844254 4857 63649292
Drug withdrawal syndrome 256.76 11.11 49 844534 31242 63622907
Lymphoma 255.97 11.11 565 844018 13376 63640773
Plasma cell myeloma 254.59 11.11 143 844440 45932 63608217
Coronary artery disease 251.15 11.11 252 844331 60181 63593968
Disease progression 250.88 11.11 979 843604 140701 63513448
Blood creatinine increased 250.30 11.11 923 843660 134859 63519290
Vomiting 249.46 11.11 5411 839172 545706 63108443
Pulmonary tuberculosis 249.24 11.11 385 844198 6859 63647290
Product use in unapproved indication 248.55 11.11 3463 841120 173155 63480994
Hypoxia 246.41 11.11 488 844095 87661 63566488
Musculoskeletal disorder 241.25 11.11 644 843939 17262 63636887
Myocardial infarction 240.55 11.11 1234 843349 164587 63489562
Device expulsion 240.46 11.11 8 844575 21128 63633021
Basal cell carcinoma 239.88 11.11 918 843665 29920 63624229
Injection site pruritus 239.70 11.11 1057 843526 36769 63617380
Bone marrow failure 239.46 11.11 1251 843332 46701 63607448
Hypomagnesaemia 237.14 11.11 96 844487 37280 63616869
Histoplasmosis disseminated 235.01 11.11 201 844382 1797 63652352
Delirium 233.00 11.11 340 844243 68854 63585295
Anti-cyclic citrullinated peptide antibody positive 229.15 11.11 1266 843317 48296 63605853
Arthritis bacterial 226.64 11.11 385 844198 7454 63646695
Disability 224.27 11.11 494 844089 11678 63642471
Injection site swelling 223.41 11.11 1103 843480 40250 63613899
Abnormal behaviour 222.22 11.11 81 844502 33541 63620608
Tuberculin test positive 222.06 11.11 236 844347 2832 63651317
Respiratory depression 221.85 11.11 24 844559 23419 63630730
Disorientation 221.65 11.11 242 844341 55586 63598563
Haematotoxicity 220.43 11.11 508 844075 12388 63641761
Pulmonary oedema 219.51 11.11 436 844147 78238 63575911
Hyperhidrosis 219.36 11.11 866 843717 124054 63530095
Suicidal ideation 219.17 11.11 332 844251 66210 63587939
Restlessness 219.07 11.11 124 844459 39661 63614488
Melaena 218.31 11.11 227 844356 53321 63600828
Blood urea increased 215.30 11.11 158 844425 43995 63610154
Dactylitis 213.88 11.11 188 844395 1750 63652399
Hyperglycaemia 213.82 11.11 291 844292 60677 63593472
Hypersensitivity 212.62 11.11 3685 840898 192767 63461382
Pulmonary embolism 212.35 11.11 1089 843494 145267 63508882
Cognitive disorder 209.76 11.11 247 844336 54840 63599309
Angioedema 208.91 11.11 303 844280 61518 63592631
Joint effusion 207.87 11.11 510 844073 12963 63641186
Mental status changes 207.44 11.11 299 844284 60863 63593286
Skin ulcer 205.80 11.11 1127 843456 42847 63611302
Off label use 205.79 11.11 10190 834393 622616 63031533
Renal failure 204.76 11.11 1464 843119 180224 63473925
Intentional product misuse 202.25 11.11 400 844183 71895 63582254
Fibromyalgia 200.16 11.11 963 843620 34768 63619381
Diverticulitis 198.72 11.11 1016 843567 37602 63616547
Impaired healing 198.49 11.11 1415 843168 59058 63595091
Myalgia 195.76 11.11 1244 843339 157373 63496776
Blood pressure decreased 194.52 11.11 535 844048 85664 63568485
Osteoporosis 191.28 11.11 1070 843513 41010 63613139
Sinus bradycardia 189.65 11.11 35 844548 22858 63631291
Chest discomfort 188.87 11.11 829 843754 115277 63538872
Pemphigus 188.14 11.11 1401 843182 59300 63594849
Exposure during pregnancy 187.57 11.11 466 844117 77209 63576940
Hallucination, visual 187.46 11.11 65 844518 27769 63626380
Myoclonus 184.77 11.11 50 844533 25068 63629081
Haemophagocytic lymphohistiocytosis 184.74 11.11 579 844004 17030 63637119
Cardiogenic shock 182.99 11.11 98 844485 32329 63621820
Polyarthritis 182.07 11.11 397 844186 9318 63644831
Urinary retention 181.62 11.11 226 844357 48975 63605174
Infusion related reaction 181.15 11.11 3094 841489 161373 63492776
Immunosuppression 181.14 11.11 421 844162 10325 63643824
Diabetic ketoacidosis 180.82 11.11 82 844501 29763 63624386
Dyspnoea exertional 180.65 11.11 439 844144 73291 63580858
Venoocclusive liver disease 180.62 11.11 403 844180 9612 63644537
Dyskinesia 180.60 11.11 150 844433 39238 63614911
White blood cell count decreased 179.69 11.11 1268 843315 156569 63497580
Juvenile idiopathic arthritis 178.86 11.11 237 844346 3642 63650507
Tenosynovitis 178.41 11.11 444 844139 11389 63642760
Breast cancer 178.27 11.11 806 843777 28342 63625807
Blood potassium decreased 177.76 11.11 160 844423 40239 63613910
Uveitis 177.25 11.11 463 844120 12245 63641904
Ventricular tachycardia 177.19 11.11 115 844468 34150 63619999
Pulmonary hypertension 176.84 11.11 182 844401 42957 63611192
Psychotic disorder 176.17 11.11 118 844465 34460 63619689
Joint destruction 175.18 11.11 227 844356 3409 63650740
Blood calcium decreased 175.02 11.11 58 844525 25496 63628653
Dysgeusia 174.82 11.11 215 844368 46832 63607317
Flushing 174.59 11.11 492 844091 78156 63575993
Hypervolaemia 174.06 11.11 147 844436 38138 63616011
Febrile bone marrow aplasia 172.53 11.11 425 844158 10830 63643319
Vision blurred 171.66 11.11 606 843977 89710 63564439
Torsade de pointes 168.92 11.11 16 844567 17347 63636802
Wheezing 165.25 11.11 523 844060 80056 63574093
Palpitations 163.37 11.11 757 843826 103731 63550418
Arrhythmia 163.18 11.11 276 844307 52668 63601481
Pulmonary mass 162.83 11.11 685 843898 23331 63630818
Hypocalcaemia 161.35 11.11 185 844398 41568 63612581
Blood alkaline phosphatase increased 160.35 11.11 308 844275 55971 63598178
Extrapyramidal disorder 159.61 11.11 31 844552 19521 63634628
Product dose omission issue 159.56 11.11 1704 842879 193043 63461106
Visceral leishmaniasis 158.05 11.11 118 844465 849 63653300
Upper gastrointestinal haemorrhage 157.96 11.11 137 844446 35083 63619066
Disseminated tuberculosis 154.84 11.11 214 844369 3431 63650718
Oedema 154.05 11.11 649 843934 91286 63562863
Poisoning 152.78 11.11 48 844535 21831 63632318
Pericarditis 151.20 11.11 1364 843219 61152 63592997
Neurotoxicity 150.91 11.11 735 843848 26669 63627480
Withdrawal syndrome 149.58 11.11 60 844523 23432 63630717
Fine motor skill dysfunction 149.58 11.11 241 844342 4458 63649691
Fear of injection 148.50 11.11 273 844310 5639 63648510
Blood sodium decreased 148.34 11.11 102 844481 29380 63624769
Epidermal necrosis 148.23 11.11 131 844452 1229 63652920
Dystonia 147.63 11.11 33 844550 18832 63635317
Miosis 147.54 11.11 6 844577 13260 63640889
Rash maculo-papular 146.92 11.11 243 844340 46783 63607366
Delusion 146.13 11.11 29 844554 17985 63636164
Product quality issue 146.11 11.11 106 844477 29693 63624456
Acute respiratory failure 144.26 11.11 271 844312 49663 63604486
Tubulointerstitial nephritis 143.83 11.11 116 844467 30793 63623356
Mycobacterium tuberculosis complex test positive 143.82 11.11 155 844428 1892 63652257
Haematemesis 142.11 11.11 248 844335 46751 63607398
Rheumatoid lung 140.65 11.11 168 844415 2311 63651838
Poisoning deliberate 140.47 11.11 9 844574 13449 63640700
Febrile neutropenia 140.39 11.11 3332 841251 184325 63469824
Circulatory collapse 139.75 11.11 141 844442 33591 63620558
Right ventricular failure 138.09 11.11 54 844529 21417 63632732
Malignant melanoma 137.59 11.11 428 844155 12536 63641613
Lung disorder 137.53 11.11 1306 843277 59394 63594755
Latent tuberculosis 137.34 11.11 175 844408 2582 63651567
Acute lymphocytic leukaemia recurrent 137.15 11.11 213 844370 3813 63650336
Graft versus host disease in gastrointestinal tract 137.01 11.11 256 844327 5356 63648793
Graft versus host disease in skin 136.95 11.11 249 844334 5098 63649051
Disturbance in attention 135.18 11.11 205 844378 40869 63613280
Blood pressure fluctuation 134.90 11.11 1150 843433 50721 63603428
Synovial cyst 134.38 11.11 306 844277 7401 63646748
Impaired work ability 134.31 11.11 472 844111 14747 63639402
Injection site warmth 133.34 11.11 434 844149 13028 63641121
Palmar-plantar erythrodysaesthesia syndrome 133.05 11.11 109 844474 28710 63625439
Injection site haemorrhage 132.14 11.11 649 843934 23629 63630520
Cerebral haemorrhage 131.72 11.11 296 844287 50794 63603355
Lymphocyte count decreased 131.19 11.11 206 844377 40493 63613656
Hypofibrinogenaemia 130.87 11.11 138 844445 1640 63652509
Lethargy 130.76 11.11 498 844085 72096 63582053
Acute graft versus host disease in intestine 130.08 11.11 196 844387 3413 63650736
Nightmare 129.83 11.11 56 844527 20937 63633212
B-cell lymphoma 129.59 11.11 246 844337 5211 63648938
Neuropathy peripheral 128.95 11.11 954 843629 116571 63537578
Mania 128.43 11.11 28 844555 16258 63637891
Glossodynia 128.24 11.11 1354 843229 63342 63590807
Sensitivity to weather change 127.68 11.11 276 844307 6438 63647711
Atrial flutter 127.54 11.11 47 844536 19333 63634816
Anhedonia 127.26 11.11 15 844568 13691 63640458
Panniculitis 126.40 11.11 326 844257 8553 63645596
Hepatic encephalopathy 125.88 11.11 59 844524 21007 63633142
Chronic kidney disease 125.84 11.11 366 844217 57553 63596596
Full blood count decreased 124.87 11.11 70 844513 22512 63631637
Muscle rigidity 124.41 11.11 37 844546 17436 63636713
Oral herpes 124.04 11.11 597 843986 21555 63632594
Device dislocation 123.97 11.11 61 844522 21117 63633032
Pustular psoriasis 122.99 11.11 207 844376 3976 63650173
Neutrophil count decreased 122.61 11.11 556 844027 76640 63577509
Contraindication to medical treatment 122.46 11.11 102 844481 876 63653273
Enthesopathy 122.19 11.11 339 844244 9299 63644850
Deep vein thrombosis 122.11 11.11 840 843743 104342 63549807
Irritability 121.31 11.11 183 844400 36563 63617586
Eosinophilia 119.64 11.11 196 844387 37880 63616269
Wound 119.64 11.11 1529 843054 74948 63579201
Haematocrit decreased 119.02 11.11 345 844238 54310 63599839
Jaundice 118.70 11.11 289 844294 48223 63605926
Cutaneous leishmaniasis 118.53 11.11 64 844519 236 63653913
Hip arthroplasty 117.81 11.11 573 844010 20778 63633371
Premature delivery 117.51 11.11 48 844535 18541 63635608
Renal impairment 117.26 11.11 1165 843418 133852 63520297
Haemoptysis 117.04 11.11 296 844287 48752 63605397
Interstitial lung disease 116.92 11.11 1864 842719 95868 63558281
Stevens-Johnson syndrome 116.55 11.11 167 844416 34082 63620067
Akathisia 116.37 11.11 9 844574 11501 63642648
Abdominal distension 115.75 11.11 758 843825 95236 63558913
Cardiac disorder 115.33 11.11 361 844222 55455 63598694
Dysphagia 115.29 11.11 871 843712 105941 63548208
Demyelination 114.38 11.11 267 844316 6567 63647582
Oropharyngeal pain 114.37 11.11 1716 842867 87151 63566998
Abdominal pain 113.87 11.11 3166 841417 309209 63344940
Depression 113.75 11.11 1701 842882 181590 63472559
Presyncope 113.68 11.11 177 844406 34912 63619237
Head injury 112.89 11.11 159 844424 32683 63621466
Haematuria 112.72 11.11 409 844174 60062 63594087
Muscle spasms 112.62 11.11 1241 843342 139782 63514367
Joint arthroplasty 112.06 11.11 136 844447 1904 63652245
Hypothermia 112.05 11.11 60 844523 19796 63634353
Histoplasmosis 111.40 11.11 135 844448 1887 63652262
Injury 110.91 11.11 369 844214 55623 63598526
Parkinsonism 110.76 11.11 26 844557 14347 63639802
Kidney transplant rejection 110.37 11.11 3 844580 9508 63644641
Sarcoidosis 109.36 11.11 246 844337 5900 63648249
Mucocutaneous ulceration 109.26 11.11 63 844520 272 63653877
Paranoia 108.72 11.11 39 844544 16313 63637836
Substance abuse 107.58 11.11 3 844580 9289 63644860
Altered state of consciousness 107.47 11.11 208 844375 37694 63616455
Emotional distress 105.50 11.11 194 844389 35844 63618305
Chronic obstructive pulmonary disease 103.92 11.11 527 844056 70521 63583628
Ill-defined disorder 102.38 11.11 953 843630 43099 63611050
Wrist deformity 102.15 11.11 122 844461 1678 63652471
Ventricular fibrillation 102.00 11.11 97 844486 23763 63630386
Creatinine renal clearance decreased 101.84 11.11 31 844552 14390 63639759
Sinus tachycardia 101.78 11.11 165 844418 32023 63622126
Atrioventricular block first degree 101.54 11.11 11 844572 10723 63643426
Gastrooesophageal reflux disease 101.52 11.11 654 843929 82489 63571660
Haematoma 101.40 11.11 291 844292 45959 63608190
Haemorrhage 101.11 11.11 616 843967 78735 63575414
Muscle twitching 100.65 11.11 62 844521 18936 63635213
Hepatotoxicity 100.26 11.11 879 843704 39083 63615066
Neoplasm progression 100.25 11.11 244 844339 40720 63613429
Pulmonary toxicity 99.67 11.11 292 844291 8269 63645880
Arthrodesis 99.51 11.11 129 844454 1938 63652211
Aphthous ulcer 99.38 11.11 383 844200 12523 63641626
Ulcer 98.83 11.11 576 844007 22414 63631735
Respiratory failure 98.57 11.11 1500 843083 159683 63494466
Lupus-like syndrome 97.74 11.11 295 844288 8496 63645653
Electrolyte imbalance 97.36 11.11 112 844471 25131 63629018
Hallucination, auditory 97.34 11.11 50 844533 16889 63637260
Drug tolerance decreased 96.61 11.11 254 844329 6744 63647405
Skin plaque 96.59 11.11 297 844286 8643 63645506
Sleep disorder due to general medical condition, insomnia type 96.47 11.11 632 843951 25638 63628511
Subdural haematoma 95.26 11.11 137 844446 27917 63626232
Inappropriate schedule of product administration 94.33 11.11 1716 842867 90570 63563579
Cystitis haemorrhagic 94.19 11.11 273 844310 7683 63646466
Heparin-induced thrombocytopenia 93.74 11.11 4 844579 8475 63645674
Dysarthria 93.06 11.11 430 844153 58976 63595173
Hepatic steatosis 92.87 11.11 710 843873 30297 63623852
General physical health deterioration 92.68 11.11 2005 842578 202420 63451729
Pulmonary arterial hypertension 92.07 11.11 118 844465 25249 63628900
Speech disorder 92.04 11.11 325 844258 48116 63606033
Caesarean section 91.76 11.11 18 844565 11256 63642893
Leukocytosis 91.41 11.11 226 844357 37514 63616635
Transfusion 90.87 11.11 62 844521 17932 63636217
Elbow deformity 90.25 11.11 97 844486 1180 63652969
Blood potassium increased 90.07 11.11 125 844458 25855 63628294
Blood glucose decreased 89.83 11.11 102 844481 23021 63631128
Sacroiliitis 89.82 11.11 150 844433 2862 63651287
Swollen tongue 89.70 11.11 203 844380 34751 63619398
Rectal haemorrhage 89.01 11.11 461 844122 61356 63592793
Cytomegalovirus chorioretinitis 88.96 11.11 198 844385 4714 63649435
Asthma 88.91 11.11 807 843776 94418 63559731
Hypovolaemia 88.56 11.11 46 844537 15440 63638709
Chronic graft versus host disease in skin 88.51 11.11 100 844483 1291 63652858
Schizophrenia 88.47 11.11 19 844564 11149 63643000
Deformity 88.41 11.11 230 844353 6067 63648082
Discomfort 88.04 11.11 1519 843064 79359 63574790
Rheumatoid factor negative 87.96 11.11 89 844494 1004 63653145
Tardive dyskinesia 87.86 11.11 9 844574 9169 63644980
Hospice care 86.34 11.11 3 844580 7622 63646527
Transient ischaemic attack 86.25 11.11 293 844290 43889 63610260
Ascites 86.14 11.11 468 844115 61533 63592616
Hyperthyroidism 86.12 11.11 67 844516 18112 63636037
Electrocardiogram QRS complex prolonged 86.12 11.11 10 844573 9234 63644915
Blood bilirubin increased 85.82 11.11 424 844159 57129 63597020
Salivary hypersecretion 85.61 11.11 26 844557 12087 63642062
Myocardial ischaemia 85.59 11.11 107 844476 23144 63631005
Acute hepatic failure 85.27 11.11 131 844452 25981 63628168
Hypophosphataemia 85.26 11.11 43 844540 14677 63639472
Troponin increased 84.76 11.11 48 844535 15351 63638798
Chromaturia 84.35 11.11 103 844480 22508 63631641
Neck pain 83.81 11.11 1200 843383 60333 63593816
Joint injury 83.62 11.11 551 844032 22396 63631753
Heart rate increased 83.34 11.11 857 843726 97818 63556331
Helicobacter infection 83.25 11.11 818 843765 37544 63616605
Cataract 83.20 11.11 1032 843551 50230 63603919
Supraventricular tachycardia 83.03 11.11 75 844508 18832 63635317
Atrioventricular block 82.75 11.11 27 844556 11988 63642161
Leukaemia recurrent 82.51 11.11 133 844450 2461 63651688
Foot operation 81.58 11.11 175 844408 4060 63650089
Lung neoplasm malignant 81.21 11.11 520 844063 20928 63633221
X-ray abnormal 81.04 11.11 99 844484 1396 63652753
Atrioventricular block complete 80.73 11.11 44 844539 14374 63639775
Spinal stenosis 80.58 11.11 379 844204 13552 63640597
Disease recurrence 80.56 11.11 696 843887 30814 63623335
White blood cell count increased 80.21 11.11 520 844063 65494 63588655
Skin lesion 80.19 11.11 780 843803 35702 63618447
Ventricular extrasystoles 80.05 11.11 67 844516 17462 63636687
Folliculitis 79.88 11.11 670 843913 29407 63624742
Blood loss anaemia 79.83 11.11 41 844542 13851 63640298
Fear 79.43 11.11 88 844495 20083 63634066
Granuloma skin 79.35 11.11 216 844367 5858 63648291
Blood magnesium decreased 78.49 11.11 42 844541 13863 63640286
Tricuspid valve incompetence 77.63 11.11 65 844518 16938 63637211
Bronchospasm 77.52 11.11 102 844481 21580 63632569
Renal injury 76.80 11.11 54 844529 15375 63638774
Peritonitis bacterial 76.70 11.11 13 844570 9030 63645119
Acidosis 76.47 11.11 72 844511 17723 63636426
Bronchitis 76.18 11.11 1914 842669 106829 63547320
Neutrophil count increased 75.95 11.11 133 844450 25041 63629108
Labelled drug-drug interaction medication error 75.64 11.11 107 844476 21955 63632194
Diabetes mellitus inadequate control 75.51 11.11 101 844482 21220 63632929
Skin cancer 75.39 11.11 334 844249 11640 63642509
Red blood cell count decreased 75.33 11.11 351 844232 48035 63606114
Pleurisy 75.07 11.11 280 844303 9011 63645138
Insomnia 74.88 11.11 1994 842589 195842 63458307
Dysuria 74.77 11.11 290 844293 41767 63612382
Sudden death 74.48 11.11 92 844491 20004 63634145
Localised infection 74.41 11.11 661 843922 29500 63624649
Shock 74.37 11.11 254 844329 37986 63616163
Shoulder arthroplasty 74.32 11.11 130 844453 2579 63651570
Hypothyroidism 73.84 11.11 276 844307 40181 63613968
Lymph node tuberculosis 73.59 11.11 76 844507 880 63653269
Treatment noncompliance 73.41 11.11 306 844277 43176 63610973
Thrombocytopenia 73.30 11.11 2301 842282 221500 63432649
Musculoskeletal deformity 73.29 11.11 64 844519 590 63653559
Lip swelling 72.73 11.11 197 844386 31710 63622439
Product substitution issue 72.47 11.11 76 844507 17785 63636364
Aspiration 71.76 11.11 69 844514 16816 63637333
Chemotherapeutic drug level increased 71.43 11.11 49 844534 303 63653846
Chondropathy 71.41 11.11 118 844465 2231 63651918
Chills 71.29 11.11 1316 843267 135948 63518201
Cholecystitis chronic 71.17 11.11 17 844566 9270 63644879
Bundle branch block right 70.86 11.11 23 844560 10246 63643903
Gamma-glutamyltransferase increased 70.83 11.11 360 844223 48150 63605999
Adult T-cell lymphoma/leukaemia 70.81 11.11 47 844536 273 63653876
Dislocation of vertebra 70.71 11.11 138 844445 2986 63651163
Injection site rash 70.67 11.11 399 844184 15343 63638806
Full blood count abnormal 70.67 11.11 180 844403 29577 63624572
Drug dependence 70.55 11.11 213 844370 33099 63621050
Hodgkin's disease 70.48 11.11 70 844513 771 63653378
Ejection fraction decreased 70.24 11.11 171 844412 28536 63625613
Angioimmunoblastic T-cell lymphoma 69.99 11.11 52 844531 371 63653778
Blood parathyroid hormone decreased 69.85 11.11 234 844349 7132 63647017
Epstein-Barr virus associated lymphoma 69.72 11.11 73 844510 860 63653289
Cyanosis 69.65 11.11 114 844469 22041 63632108
End stage renal disease 69.62 11.11 25 844558 10450 63643699
Mydriasis 69.34 11.11 59 844524 15253 63638896
Catatonia 69.13 11.11 9 844574 7611 63646538
Non-alcoholic steatohepatitis 68.92 11.11 105 844478 1847 63652302
Complications of bone marrow transplant 68.88 11.11 61 844522 574 63653575
Fungal infection 68.88 11.11 719 843864 33532 63620617
Pneumonia cryptococcal 68.71 11.11 83 844500 1156 63652993
Cutaneous T-cell lymphoma 68.63 11.11 116 844467 2236 63651913
Inflammatory marker increased 68.54 11.11 255 844328 8196 63645953
Cytokine release syndrome 68.49 11.11 104 844479 20725 63633424
Arachnoiditis 68.46 11.11 63 844520 626 63653523
Transplant rejection 68.43 11.11 76 844507 17325 63636824
Angina pectoris 67.86 11.11 331 844252 44750 63609399
Haemorrhage intracranial 67.77 11.11 131 844452 23753 63630396
Mycobacterial infection 67.64 11.11 132 844451 2856 63651293
Limb deformity 67.19 11.11 141 844442 3220 63650929
Hepatic enzyme abnormal 66.87 11.11 198 844385 5641 63648508
Bradyphrenia 66.82 11.11 20 844563 9386 63644763
Neuroendocrine carcinoma of the skin 66.77 11.11 74 844509 934 63653215
Skin erosion 66.59 11.11 153 844430 3723 63650426
Product administration error 66.59 11.11 166 844417 27477 63626672
Epicondylitis 65.97 11.11 100 844483 1751 63652398
Flatulence 65.96 11.11 242 844341 35424 63618725
Depressed mood 65.94 11.11 294 844289 40718 63613431
Erythema multiforme 65.76 11.11 65 844518 15636 63638513
Bronchitis chronic 65.13 11.11 153 844430 3779 63650370
Psychomotor hyperactivity 65.05 11.11 56 844527 14395 63639754
Ankle deformity 64.83 11.11 60 844523 601 63653548
Pallor 64.80 11.11 274 844309 38507 63615642
Respiratory acidosis 64.68 11.11 24 844559 9831 63644318
Medial tibial stress syndrome 64.44 11.11 33 844550 106 63654043
Tonsillitis 64.42 11.11 195 844388 5625 63648524
Seronegative arthritis 64.33 11.11 123 844460 2620 63651529
Pneumonia legionella 64.04 11.11 115 844468 2331 63651818
Acute coronary syndrome 63.90 11.11 96 844487 19214 63634935
Toxic epidermal necrolysis 63.71 11.11 260 844323 36906 63617243
Irritable bowel syndrome 63.55 11.11 759 843824 36610 63617539
Respiratory distress 63.18 11.11 413 844170 51918 63602231
Faeces discoloured 63.16 11.11 153 844430 25576 63628573
Injection site urticaria 63.08 11.11 302 844281 10879 63643270
Body height below normal 63.07 11.11 97 844486 1721 63652428
Anuria 63.02 11.11 94 844489 18870 63635279
Epstein-Barr virus infection reactivation 62.86 11.11 77 844506 1089 63653060
Apparent death 62.76 11.11 120 844463 2556 63651593
Venoocclusive disease 62.70 11.11 152 844431 3833 63650316
SLE arthritis 62.68 11.11 54 844529 488 63653661
Cytomegalovirus infection 62.58 11.11 754 843829 36445 63617704
Angina unstable 62.54 11.11 66 844517 15401 63638748
Muscle injury 62.47 11.11 574 844009 25863 63628286
Intervertebral disc space narrowing 62.37 11.11 83 844500 1281 63652868
Electrocardiogram abnormal 62.21 11.11 51 844532 13430 63640719
Dialysis 62.14 11.11 78 844505 16842 63637307
Urinary tract infection 62.09 11.11 2441 842142 229155 63424994
Cerebral infarction 61.99 11.11 301 844282 40743 63613406
Faecaloma 61.68 11.11 25 844558 9703 63644446
Prothrombin time prolonged 61.62 11.11 69 844514 15672 63638477
Tenderness 61.61 11.11 454 844129 19148 63635001
Urinary incontinence 61.28 11.11 254 844329 35897 63618252
Mycobacterium marinum infection 61.06 11.11 47 844536 356 63653793
Glycosylated haemoglobin increased 60.78 11.11 72 844511 15947 63638202
Epistaxis 60.72 11.11 911 843672 97220 63556929
Surgical failure 60.57 11.11 63 844520 736 63653413
Status epilepticus 60.45 11.11 120 844463 21543 63632606
Atypical mycobacterial infection 60.44 11.11 80 844503 1228 63652921
Investigation abnormal 60.26 11.11 81 844502 1263 63652886
Aspartate aminotransferase increased 60.17 11.11 1155 843428 118633 63535516
Secondary immunodeficiency 60.05 11.11 119 844464 2605 63651544
Rheumatoid factor increased 59.95 11.11 83 844500 1333 63652816
Acute graft versus host disease in liver 59.92 11.11 91 844492 1596 63652553
Ischaemic stroke 59.82 11.11 188 844395 28847 63625302
Gastric disorder 59.70 11.11 615 843968 28582 63625567
Spondyloarthropathy 59.63 11.11 62 844521 724 63653425
Mitral valve incompetence 59.48 11.11 156 844427 25382 63628767
Drug screen positive 59.30 11.11 4 844579 5725 63648424
Ileus 59.24 11.11 133 844450 22833 63631316
Epilepsy 59.10 11.11 232 844351 33299 63620850
Hepatitis B reactivation 59.08 11.11 169 844414 4720 63649429
Varicella zoster virus infection 58.73 11.11 146 844437 3742 63650407
Hepatic failure 58.67 11.11 454 844129 54940 63599209
Complications of transplanted kidney 58.67 11.11 3 844580 5432 63648717
Arthritis infective 58.59 11.11 214 844369 6816 63647333
Erectile dysfunction 57.99 11.11 48 844535 12579 63641570
Oxygen saturation decreased 57.70 11.11 1021 843562 106155 63547994
Hyperlipidaemia 57.69 11.11 135 844448 22841 63631308
Joint noise 57.66 11.11 129 844454 3082 63651067
Scleritis 57.63 11.11 123 844460 2843 63651306
Obstructive airways disorder 57.60 11.11 137 844446 23048 63631101
Therapeutic response shortened 57.60 11.11 275 844308 9895 63644254
Lennox-Gastaut syndrome 57.50 11.11 36 844547 186 63653963
Adenovirus infection 57.25 11.11 217 844366 7038 63647111
Renal tubular necrosis 57.06 11.11 128 844455 21982 63632167
Hypoxic-ischaemic encephalopathy 57 11.11 12 844571 7140 63647009
Acute generalised exanthematous pustulosis 56.83 11.11 60 844523 13998 63640151
Mycobacterium chelonae infection 56.62 11.11 101 844482 2036 63652113
Duodenal ulcer perforation 56.58 11.11 698 843885 33927 63620222
Oral mucosal exfoliation 56.42 11.11 80 844503 1315 63652834
Therapy non-responder 56.40 11.11 1193 843390 64706 63589443
Pharyngitis streptococcal 56.26 11.11 244 844339 8424 63645725
Myocarditis 56.13 11.11 85 844498 16958 63637191
Hypersensitivity pneumonitis 55.99 11.11 128 844455 3104 63651045
Amyotrophic lateral sclerosis 55.79 11.11 87 844496 1563 63652586
Unevaluable event 55.75 11.11 409 844174 50080 63604069
Oral disorder 55.53 11.11 248 844335 8673 63645476
Temporal lobe epilepsy 55.52 11.11 43 844540 329 63653820
Dry skin 55.27 11.11 417 844166 50744 63603405
Poor venous access 55.26 11.11 314 844269 12103 63642046
Bradypnoea 55.21 11.11 3 844580 5156 63648993
Bacterial infection 55.10 11.11 534 844049 24416 63629733
Adverse reaction 55.05 11.11 223 844360 7464 63646685
Hepatic fibrosis 54.99 11.11 179 844404 5373 63648776
Long QT syndrome 54.96 11.11 3 844580 5136 63649013
Uterine perforation 54.96 11.11 6 844577 5814 63648335
Mental disorder 54.65 11.11 171 844412 26274 63627875
Engraftment syndrome 54.42 11.11 70 844513 1043 63653106
Mucosal ulceration 54.19 11.11 88 844495 1639 63652510
Tooth abscess 54.07 11.11 338 844245 13488 63640661
Activated partial thromboplastin time prolonged 53.87 11.11 53 844530 12778 63641371
Infusion site pain 53.61 11.11 35 844548 10362 63643787
Anaphylactic shock 53.35 11.11 210 844373 30118 63624031
Polyuria 53.34 11.11 52 844531 12591 63641558
Glaucoma 53.31 11.11 382 844201 15966 63638183
Physical disability 53.02 11.11 102 844481 2183 63651966
Device occlusion 53.00 11.11 32 844551 9881 63644268
Cardiac failure chronic 52.98 11.11 26 844557 9015 63645134
Hypomania 52.96 11.11 6 844577 5648 63648501
Face oedema 52.67 11.11 158 844425 24603 63629546
Influenza 52.64 11.11 1795 842788 104736 63549413
Euglycaemic diabetic ketoacidosis 52.59 11.11 5 844578 5405 63648744
Lower gastrointestinal haemorrhage 52.52 11.11 63 844520 13876 63640273
Joint dislocation 52.40 11.11 292 844291 11173 63642976
Bradykinesia 52.30 11.11 11 844572 6549 63647600
Pharyngitis 52.09 11.11 427 844156 18612 63635537
Limb discomfort 52.09 11.11 565 844018 26610 63627539
Intentional product use issue 51.80 11.11 1625 842958 93739 63560410
Hypercapnia 51.75 11.11 18 844565 7676 63646473
Immobile 51.74 11.11 185 844398 5830 63648319
Squamous cell carcinoma of lung 51.71 11.11 94 844489 1924 63652225
Blood pressure diastolic abnormal 51.49 11.11 299 844284 11618 63642531
Cytomegalovirus infection reactivation 51.20 11.11 179 844404 5577 63648572
Joint lock 51.14 11.11 114 844469 2717 63651432
Brain natriuretic peptide increased 51.10 11.11 18 844565 7615 63646534
Glioma 51.00 11.11 48 844535 492 63653657
Immunodeficiency 50.99 11.11 374 844209 15750 63638399
Premature labour 50.96 11.11 18 844565 7602 63646547
Drug specific antibody present 50.90 11.11 166 844417 4988 63649161
Pulseless electrical activity 50.80 11.11 55 844528 12684 63641465
Urine output decreased 50.78 11.11 86 844497 16406 63637743
Haemorrhagic stroke 50.63 11.11 34 844549 9917 63644232
Respiratory tract congestion 50.57 11.11 374 844209 15791 63638358
Complication of device insertion 50.44 11.11 4 844579 5008 63649141
Drug specific antibody 50.44 11.11 95 844488 2000 63652149
Extranodal marginal zone B-cell lymphoma (MALT type) 50.38 11.11 47 844536 476 63653673
Blood pressure systolic abnormal 50.04 11.11 260 844323 9682 63644467
Coordination abnormal 49.90 11.11 74 844509 14890 63639259
Exposure to toxic agent 49.78 11.11 10 844573 6149 63648000
Failure to thrive 49.72 11.11 38 844545 10366 63643783
Ischaemic cardiomyopathy 49.57 11.11 14 844569 6824 63647325
Bone swelling 49.53 11.11 70 844513 1147 63653002
Thinking abnormal 49.37 11.11 47 844536 11509 63642640
Liver disorder 49.34 11.11 977 843606 52374 63601775
Osteonecrosis of jaw 49.25 11.11 312 844271 39513 63614636
Pleuropericarditis 49.15 11.11 42 844541 375 63653774
Glomerular filtration rate decreased 49.14 11.11 115 844468 19457 63634692
Atrioventricular block second degree 49.09 11.11 12 844571 6442 63647707
Lymphadenopathy 49.06 11.11 872 843711 45814 63608335
Complication associated with device 48.91 11.11 76 844507 15004 63639145
Lung adenocarcinoma 48.76 11.11 198 844385 6635 63647514
Myelitis 48.60 11.11 94 844489 2020 63652129
Acute myeloid leukaemia 48.55 11.11 562 844021 26901 63627248
Dermatitis acneiform 48.40 11.11 25 844558 8418 63645731
Encephalitis 48.34 11.11 306 844277 12265 63641884
Onychomycosis 48.33 11.11 164 844419 5032 63649117
Nasal ulcer 48.21 11.11 78 844505 1448 63652701
Abnormal dreams 48.01 11.11 39 844544 10317 63643832
Hyperthermia 47.96 11.11 81 844502 15469 63638680
Pancreatitis acute 47.88 11.11 346 844237 42509 63611640
Angioimmunoblastic T-cell lymphoma stage IV 47.86 11.11 16 844567 7 63654142
Ophthalmic herpes zoster 47.65 11.11 95 844488 2089 63652060
Vein rupture 47.57 11.11 78 844505 1465 63652684
Pemphigoid 47.55 11.11 60 844523 12926 63641223
Hypophagia 47.49 11.11 313 844270 39274 63614875
Dementia 47.49 11.11 128 844455 20638 63633511
Ear infection 47.39 11.11 492 844091 22912 63631237
Generalised tonic-clonic seizure 47.38 11.11 316 844267 39541 63614608
Ageusia 47.34 11.11 67 844516 13746 63640403
Clinodactyly 47.20 11.11 16 844567 8 63654141
Atlantoaxial instability 47.15 11.11 36 844547 269 63653880
Superior sagittal sinus thrombosis 47.12 11.11 61 844522 915 63653234
Ventricular arrhythmia 47.11 11.11 19 844564 7396 63646753
Electrocardiogram ST segment elevation 47.10 11.11 18 844565 7241 63646908
Breast cancer stage III 46.99 11.11 112 844471 2793 63651356
Somnambulism 46.82 11.11 6 844577 5135 63649014
Nephrogenic systemic fibrosis 46.72 11.11 10 844573 5882 63648267
Mineral metabolism disorder 46.32 11.11 36 844547 277 63653872
Ketoacidosis 46.26 11.11 16 844567 6847 63647302
Skin necrosis 46.25 11.11 334 844249 13995 63640154
Tachypnoea 46.09 11.11 185 844398 26386 63627763
Ear pain 46.07 11.11 518 844065 24618 63629531
Abscess 46.05 11.11 420 844163 18884 63635265
Epstein-Barr virus antigen positive 46.04 11.11 23 844560 69 63654080
Pollakiuria 46.02 11.11 234 844349 31296 63622853
Anger 45.84 11.11 85 844498 15656 63638493
Pleural effusion 45.68 11.11 1284 843299 125275 63528874
Retching 45.66 11.11 81 844502 15175 63638974
Human antichimeric antibody positive 45.59 11.11 73 844510 1343 63652806
Cholestasis 45.56 11.11 372 844211 44500 63609649
Swelling face 45.49 11.11 525 844058 58641 63595508
Synovial disorder 45.38 11.11 59 844524 889 63653260
Gestational diabetes 45.34 11.11 9 844574 5581 63648568
Bundle branch block left 45.03 11.11 39 844544 9995 63644154
Erythrodermic psoriasis 44.92 11.11 77 844506 1502 63652647
Bone cyst 44.89 11.11 93 844490 2104 63652045
Disability assessment scale score increased 44.72 11.11 101 844482 2429 63651720
Myelitis transverse 44.67 11.11 78 844505 1545 63652604
Tooth infection 44.65 11.11 336 844247 14265 63639884
Wrong technique in product usage process 44.51 11.11 591 843992 64383 63589766
Asphyxia 44.38 11.11 36 844547 9530 63644619
Foot fracture 44.31 11.11 397 844186 17760 63636389
Hyperreflexia 44.31 11.11 19 844564 7129 63647020
Memory impairment 44.30 11.11 822 843761 84860 63569289
Colitis ulcerative 44.24 11.11 479 844104 22549 63631600
Eye disorder 44.23 11.11 409 844174 18460 63635689
Myelodysplastic syndrome 44.22 11.11 554 844029 27025 63627124
Metabolic encephalopathy 44.19 11.11 25 844558 8000 63646149
Device difficult to use 44.07 11.11 38 844545 9760 63644389
Hyperuricaemia 44.07 11.11 41 844542 10150 63643999
Bone pain 44.02 11.11 404 844179 47168 63606981
Molluscum contagiosum 43.81 11.11 41 844542 417 63653732
Synovectomy 43.81 11.11 31 844552 203 63653946
Deafness transitory 43.80 11.11 54 844529 769 63653380
Wrist surgery 43.78 11.11 51 844532 682 63653467
Device use error 43.77 11.11 15 844568 6456 63647693
Device leakage 43.75 11.11 27 844556 8239 63645910
Spinal pain 43.55 11.11 299 844284 12322 63641827
Paraesthesia 43.54 11.11 1385 843198 133137 63521012
Intestinal obstruction 43.48 11.11 287 844296 35999 63618150
Squamous cell carcinoma 43.46 11.11 321 844262 13548 63640601
Spinal instability 43.15 11.11 37 844546 332 63653817
Vertigo 42.93 11.11 530 844053 58481 63595668
Blood pressure diastolic decreased 42.90 11.11 464 844119 21837 63632312
Osteopenia 42.77 11.11 349 844234 15191 63638958
Abscess limb 42.75 11.11 177 844406 5984 63648165
Joint laxity 42.72 11.11 94 844489 2220 63651929
Drug ineffective for unapproved indication 42.72 11.11 608 843975 30525 63623624
Cardiac failure acute 42.69 11.11 94 844489 16250 63637899
Hepatitis cholestatic 42.62 11.11 58 844525 12097 63642052
Extrapulmonary tuberculosis 42.46 11.11 37 844546 340 63653809
Organising pneumonia 42.30 11.11 232 844351 8823 63645326
Chemotherapeutic drug level above therapeutic 42.30 11.11 20 844563 51 63654098
Cardiomegaly 42.30 11.11 163 844420 23521 63630628
Osteoporotic fracture 42.15 11.11 123 844460 3475 63650674
Rash 42.13 11.11 6727 837856 451822 63202327
Haemodynamic instability 42.13 11.11 82 844501 14830 63639319
Proteinuria 42.04 11.11 203 844380 27520 63626629
Bone tuberculosis 42.03 11.11 41 844542 441 63653708
Sciatica 41.98 11.11 428 844155 19836 63634313
Iritis 41.90 11.11 112 844471 3004 63651145
Oral mucosa erosion 41.84 11.11 78 844505 1629 63652520
Coma scale abnormal 41.70 11.11 25 844558 7749 63646400
Therapy change 41.67 11.11 16 844567 6418 63647731
Hepatic cirrhosis 41.63 11.11 527 844056 25771 63628378
Hyperprolactinaemia 41.60 11.11 3 844580 4062 63650087
Thrombosis 41.59 11.11 662 843921 69980 63584169
Forced expiratory volume decreased 41.39 11.11 19 844564 6848 63647301
Transaminases increased 41.36 11.11 817 843766 43777 63610372
Bursitis 41.32 11.11 447 844136 21038 63633111
Alveolitis 41.15 11.11 124 844459 3568 63650581
Neoplasm recurrence 41.13 11.11 125 844458 3614 63650535
Shock haemorrhagic 41.09 11.11 100 844483 16691 63637458
Aspiration bone marrow abnormal 41.03 11.11 25 844558 122 63654027
Secretion discharge 41.02 11.11 283 844300 11681 63642468
Product complaint 40.96 11.11 58 844525 11896 63642253
Hiccups 40.79 11.11 30 844553 8346 63645803
Haemodialysis 40.78 11.11 103 844480 16974 63637175
Dry eye 40.74 11.11 569 844014 28450 63625699
Hepatitis E 40.71 11.11 95 844488 2336 63651813
Coronary arterial stent insertion 40.62 11.11 12 844571 5680 63648469
Inflammatory pain 40.55 11.11 53 844530 803 63653346
International normalised ratio abnormal 40.52 11.11 8 844575 4980 63649169
Alcohol interaction 40.41 11.11 5 844578 4396 63649753
Thyroid neoplasm 40.37 11.11 100 844483 2557 63651592
Peritoneal tuberculosis 40.35 11.11 41 844542 465 63653684
Tuberculous pleurisy 40.33 11.11 44 844539 545 63653604
Acute pulmonary oedema 40.18 11.11 66 844517 12743 63641406
Oxygen consumption increased 40.17 11.11 6 844577 4575 63649574
Inappropriate antidiuretic hormone secretion 40.06 11.11 153 844430 22136 63632013
Cardiomyopathy 40.02 11.11 183 844400 25173 63628976
Infusion site erythema 39.92 11.11 20 844563 6853 63647296
Anal fistula 39.72 11.11 155 844428 5098 63649051
Pre-eclampsia 39.53 11.11 16 844567 6215 63647934
Amylase increased 39.53 11.11 41 844542 9644 63644505
Rhinorrhoea 39.49 11.11 1047 843536 58922 63595227
Mucosal toxicity 39.48 11.11 40 844543 452 63653697
Pseudomonal sepsis 39.42 11.11 153 844430 5019 63649130
Ovarian cancer 39.40 11.11 114 844469 3205 63650944
Ventricular hypertrophy 39.32 11.11 18 844565 6498 63647651
Arteriosclerosis 39.30 11.11 94 844489 15783 63638366
Diffuse large B-cell lymphoma stage IV 39.28 11.11 40 844543 455 63653694
Refusal of treatment by patient 39.17 11.11 31 844552 8308 63645841
Bone disorder 39.15 11.11 363 844220 16396 63637753
Left ventricular dysfunction 39.15 11.11 104 844479 16850 63637299
Varicella 39.15 11.11 98 844485 2523 63651626
Palmoplantar pustulosis 39.14 11.11 40 844543 457 63653692
Hepatosplenic T-cell lymphoma 39.10 11.11 51 844532 771 63653378
Paraesthesia oral 39.04 11.11 70 844513 13061 63641088
Hypernatraemia 38.99 11.11 62 844521 12127 63642022
Ovarian neoplasm 38.96 11.11 43 844540 540 63653609
Cancer pain 38.69 11.11 5 844578 4252 63649897
Aplasia 38.64 11.11 187 844396 6766 63647383
Clear cell renal cell carcinoma 38.53 11.11 87 844496 2092 63652057
Lipodystrophy acquired 38.42 11.11 4 844579 4023 63650126
Blood glucose fluctuation 38.26 11.11 15 844568 5940 63648209
Knee deformity 38.11 11.11 53 844530 855 63653294
Obliterative bronchiolitis 38.09 11.11 98 844485 2567 63651582
Lyme disease 37.87 11.11 92 844491 2323 63651826
Infective tenosynovitis 37.86 11.11 32 844551 281 63653868
Priapism 37.73 11.11 4 844579 3966 63650183
Azotaemia 37.68 11.11 26 844557 7476 63646673
Therapeutic product effect delayed 37.51 11.11 95 844488 2464 63651685
Mesenteritis 37.43 11.11 27 844556 183 63653966
Lung cancer metastatic 37.42 11.11 108 844475 3032 63651117
Dyspnoea at rest 37.39 11.11 18 844565 6311 63647838
Cerebral venous sinus thrombosis 37.29 11.11 78 844505 1777 63652372
Skin mass 37.28 11.11 188 844395 6918 63647231
Leukopenia 37.27 11.11 1652 842931 99590 63554559
Second primary malignancy 37.22 11.11 283 844300 12054 63642095
Tonsillar ulcer 37.21 11.11 36 844547 383 63653766
Post procedural haemorrhage 37.20 11.11 66 844517 12365 63641784
Performance status decreased 37.04 11.11 12 844571 5352 63648797
Pericardial effusion 36.91 11.11 332 844251 38922 63615227
C-reactive protein decreased 36.87 11.11 84 844499 2032 63652117
Hyperlactacidaemia 36.86 11.11 9 844574 4835 63649314
Injection site discolouration 36.85 11.11 183 844400 6692 63647457
Dizziness postural 36.82 11.11 44 844539 9708 63644441
Diffuse large B-cell lymphoma stage III 36.79 11.11 20 844563 75 63654074
Blood bicarbonate decreased 36.69 11.11 9 844574 4820 63649329
Hepatitis B virus test positive 36.53 11.11 37 844546 418 63653731
Nail disorder 36.37 11.11 215 844368 8409 63645740
Cyst 36.35 11.11 276 844307 11751 63642398
Joint warmth 36.34 11.11 66 844517 1350 63652799
Product monitoring error 36.27 11.11 13 844570 5441 63648708
Carcinoma in situ of skin 36.14 11.11 25 844558 157 63653992
Small intestinal obstruction 36.10 11.11 172 844411 23401 63630748
Carpal tunnel syndrome 36.06 11.11 341 844242 15487 63638662
Hypoaesthesia oral 36.01 11.11 60 844523 11520 63642629
Osteosclerosis 35.99 11.11 114 844469 3372 63650777
Vascular access complication 35.89 11.11 57 844526 1041 63653108
Abscess bacterial 35.87 11.11 47 844536 714 63653435
Cholelithiasis 35.68 11.11 402 844181 45104 63609045
Granulomatosis with polyangiitis 35.67 11.11 83 844500 2037 63652112
Personality change 35.50 11.11 36 844547 8557 63645592
Subarachnoid haemorrhage 35.49 11.11 123 844460 18315 63635834
Non-Hodgkin's lymphoma 35.46 11.11 67 844516 1414 63652735
Granulocytopenia 35.43 11.11 51 844532 10389 63643760
Mood altered 35.42 11.11 100 844483 15879 63638270
Viral vasculitis 35.41 11.11 23 844560 128 63654021
Hypophysitis 35.38 11.11 3 844580 3556 63650593
Muscle tightness 35.12 11.11 57 844526 11058 63643091
Episcleritis 35.12 11.11 49 844534 793 63653356
Blood lactic acid increased 35.11 11.11 51 844532 10350 63643799
Decreased immune responsiveness 35.07 11.11 133 844450 4315 63649834
Spinal column injury 35.07 11.11 76 844507 1776 63652373
Granuloma 35.05 11.11 176 844407 6465 63647684
Blood prolactin increased 35.00 11.11 3 844580 3525 63650624
Dry mouth 34.96 11.11 568 844015 59850 63594299
Gait disturbance 34.93 11.11 2662 841921 169493 63484656
Cutaneous lymphoma 34.88 11.11 28 844555 227 63653922
International normalised ratio decreased 34.87 11.11 28 844555 7450 63646699
Faecal calprotectin increased 34.84 11.11 116 844467 3524 63650625
Gastric haemorrhage 34.83 11.11 78 844505 13403 63640746
Clonus 34.72 11.11 18 844565 6049 63648100
Hypergammaglobulinaemia benign monoclonal 34.69 11.11 44 844539 646 63653503
Hallucinations, mixed 34.57 11.11 18 844565 6034 63648115
Joint space narrowing 34.41 11.11 27 844556 211 63653938
Epstein-Barr viraemia 34.32 11.11 74 844509 1723 63652426
Exostosis 34.30 11.11 262 844321 11176 63642973
Cold sweat 34.28 11.11 106 844477 16349 63637800
Sleep apnoea syndrome 34.23 11.11 239 844344 29593 63624556
Cardioactive drug level increased 34.23 11.11 3 844580 3462 63650687
Tinnitus 34.18 11.11 284 844299 33849 63620300
Alcohol use 34.15 11.11 9 844574 4593 63649556
Acute pulmonary histoplasmosis 34.02 11.11 27 844556 215 63653934
Spinal disorder 33.97 11.11 213 844370 8509 63645640
Body temperature decreased 33.85 11.11 502 844081 25426 63628723
Incorrect product administration duration 33.77 11.11 47 844536 9711 63644438
Human rhinovirus test positive 33.71 11.11 34 844549 382 63653767
Immune system disorder 33.61 11.11 220 844363 8921 63645228
Device breakage 33.59 11.11 39 844544 8716 63645433
Rheumatoid vasculitis 33.58 11.11 35 844548 410 63653739
Adverse drug reaction 33.55 11.11 806 843777 44658 63609491
Angioimmunoblastic T-cell lymphoma stage III 33.49 11.11 10 844573 0 63654149
Prescribed underdose 33.46 11.11 122 844461 17893 63636256
Bicytopenia 33.41 11.11 114 844469 3508 63650641
Blood stem cell transplant failure 33.26 11.11 38 844545 497 63653652
Alcohol abuse 33.25 11.11 11 844572 4841 63649308
Chronic graft versus host disease in intestine 33.15 11.11 29 844554 268 63653881
Arteriosclerosis coronary artery 33.09 11.11 99 844484 15430 63638719
Aplasia pure red cell 33.04 11.11 26 844557 6988 63647161
Psychomotor retardation 32.96 11.11 13 844570 5130 63649019
Leishmaniasis 32.92 11.11 31 844552 318 63653831
Respiration abnormal 32.91 11.11 21 844562 6294 63647855
Anaplastic large-cell lymphoma 32.89 11.11 24 844559 166 63653983
Retinal toxicity 32.88 11.11 61 844522 1269 63652880
Visual acuity reduced 32.86 11.11 214 844369 26927 63627222
Bunion operation 32.85 11.11 46 844537 747 63653402
Pulmonary arterial pressure increased 32.61 11.11 7 844576 4109 63650040
Morphoea 32.57 11.11 33 844550 373 63653776
Lung transplant 32.52 11.11 7 844576 4101 63650048
Diastolic dysfunction 32.50 11.11 41 844542 8834 63645315
Joint ankylosis 32.44 11.11 45 844538 724 63653425
Axial spondyloarthritis 32.43 11.11 33 844550 375 63653774
Rheumatic disorder 32.39 11.11 66 844517 1475 63652674
Toxic skin eruption 32.36 11.11 136 844447 19148 63635001
Urine ketone body present 32.30 11.11 3 844580 3304 63650845
Mucocutaneous leishmaniasis 32.25 11.11 34 844549 404 63653745
Hypotonia 32.24 11.11 61 844522 11151 63642998
Stress 32.21 11.11 1029 843554 59505 63594644
Lip ulceration 32.21 11.11 77 844506 1924 63652225
Thrombosis in device 32.20 11.11 13 844570 5058 63649091
Multiple injuries 32.20 11.11 3 844580 3296 63650853
Cerebral haematoma 32.15 11.11 28 844555 7157 63646992
Hypovolaemic shock 32.10 11.11 53 844530 10213 63643936
Disturbance in social behaviour 32.07 11.11 6 844577 3881 63650268
Pseudostroke 32.03 11.11 16 844567 48 63654101
Herpes simplex 31.96 11.11 242 844341 10294 63643855
West Nile viral infection 31.92 11.11 49 844534 868 63653281
Blood chloride decreased 31.87 11.11 30 844553 7386 63646763
Antinuclear antibody positive 31.84 11.11 164 844419 6086 63648063
Blood thyroid stimulating hormone increased 31.69 11.11 32 844551 7622 63646527
Duodenal ulcer haemorrhage 31.66 11.11 22 844561 6303 63647846
Viral upper respiratory tract infection 31.61 11.11 200 844383 8015 63646134
Iris adhesions 31.58 11.11 37 844546 498 63653651
Bronchial carcinoma 31.55 11.11 55 844528 1088 63653061
Incoherent 31.54 11.11 28 844555 7090 63647059
Transaminases abnormal 31.54 11.11 44 844539 712 63653437
Myelodysplastic syndrome transformation 31.53 11.11 41 844542 618 63653531
Epstein-Barr virus test positive 31.51 11.11 51 844532 947 63653202
Anaemia megaloblastic 31.50 11.11 36 844547 471 63653678
Neoplasm malignant 31.46 11.11 476 844107 24212 63629937
Immune thrombocytopenia 31.43 11.11 97 844486 14969 63639180
Rheumatic fever 31.37 11.11 219 844364 9075 63645074
Metastases to bone 31.36 11.11 149 844434 20286 63633863
Swollen joint count increased 31.35 11.11 190 844393 7499 63646650
Cytomegalovirus viraemia 31.34 11.11 246 844337 10582 63643567
Thrombotic microangiopathy 31.33 11.11 345 844238 16310 63637839
Amnesia 31.28 11.11 444 844139 47825 63606324
Intervertebral disc protrusion 31.27 11.11 403 844180 19788 63634361
Inhibitory drug interaction 31.24 11.11 5 844578 3622 63650527
Skin papilloma 31.16 11.11 143 844440 5060 63649089
Injection site inflammation 31.14 11.11 103 844480 3118 63651031
Anaemia macrocytic 31.03 11.11 127 844456 4271 63649878
Adverse event 30.96 11.11 706 843877 38783 63615366
Mucormycosis 30.95 11.11 183 844400 7158 63646991
Urine leukocyte esterase positive 30.92 11.11 4 844579 3399 63650750
Meningoencephalitis herpetic 30.79 11.11 70 844513 1691 63652458
Osteomyelitis 30.68 11.11 520 844063 27067 63627082
Nail psoriasis 30.55 11.11 31 844552 351 63653798
Herpes virus infection 30.54 11.11 162 844421 6082 63648067
Hypoglycaemic coma 30.52 11.11 9 844574 4265 63649884
Pyoderma gangrenosum 30.41 11.11 100 844483 3018 63651131
Cutaneous vasculitis 30.34 11.11 166 844417 6307 63647842
Cerebral toxoplasmosis 30.19 11.11 71 844512 1755 63652394
Nocturia 30.17 11.11 63 844520 11102 63643047
Infusion site swelling 30.13 11.11 17 844566 5448 63648701
Blood pH decreased 30.13 11.11 10 844573 4392 63649757
Compartment syndrome 30.06 11.11 9 844574 4223 63649926
Iridocyclitis 30.00 11.11 98 844485 2947 63651202
Coccidioidomycosis 29.97 11.11 53 844530 1061 63653088
Subdural haemorrhage 29.96 11.11 16 844567 5287 63648862
Throat tightness 29.90 11.11 179 844404 22981 63631168
Product prescribing error 29.89 11.11 306 844277 34963 63619186
Drug eruption 29.89 11.11 651 843932 35485 63618664
Blood triglycerides increased 29.87 11.11 136 844447 18730 63635419
Intestinal ischaemia 29.69 11.11 67 844516 11482 63642667
Haemolytic anaemia 29.63 11.11 109 844474 15944 63638205
Acute myeloid leukaemia recurrent 29.62 11.11 92 844491 2692 63651457
Bursitis infective 29.62 11.11 55 844528 1145 63653004
Ankle operation 29.58 11.11 50 844533 964 63653185
Gout 29.53 11.11 162 844421 21251 63632898
Neck mass 29.51 11.11 118 844465 3926 63650223
Eye swelling 29.41 11.11 171 844412 22110 63632039
Blood pressure inadequately controlled 29.32 11.11 17 844566 5367 63648782
Coronary artery occlusion 29.28 11.11 89 844494 13802 63640347
Toxic leukoencephalopathy 29.22 11.11 47 844536 868 63653281
Sputum increased 29.17 11.11 6 844577 3629 63650520
Ammonia increased 29.09 11.11 29 844554 6948 63647201
Keratitis 29.09 11.11 101 844482 3136 63651013
Abdominal wall haematoma 29.08 11.11 10 844573 4295 63649854
Embolic stroke 29.02 11.11 27 844556 6684 63647465
Pneumonitis 28.88 11.11 864 843719 49501 63604648
Choking 28.87 11.11 59 844524 10479 63643670
Mental impairment 28.85 11.11 113 844470 16230 63637919
Normal newborn 28.84 11.11 19 844564 5598 63648551
Muscle haemorrhage 28.81 11.11 20 844563 5733 63648416
Blood pressure diastolic increased 28.80 11.11 240 844343 10512 63643637
Thirst 28.80 11.11 92 844491 14045 63640104
Systemic lupus erythematosus rash 28.74 11.11 60 844523 1365 63652784
JC virus infection 28.70 11.11 103 844480 3252 63650897
Drooling 28.68 11.11 17 844566 5302 63648847
Application site pain 28.47 11.11 10 844573 4238 63649911
Invasive ductal breast carcinoma 28.31 11.11 136 844447 4906 63649243
Musculoskeletal discomfort 28.29 11.11 332 844251 15945 63638204
Ganglioneuroma 28.26 11.11 20 844563 131 63654018
Colitis ischaemic 28.24 11.11 86 844497 13328 63640821
Toe operation 28.23 11.11 34 844549 472 63653677
Pregnancy with contraceptive device 28.20 11.11 4 844579 3170 63650979
Panic attack 28.09 11.11 160 844423 20793 63633356
Obsessive-compulsive disorder 28.01 11.11 14 844569 4804 63649345
Communication disorder 27.98 11.11 7 844576 3699 63650450
Viral mutation identified 27.96 11.11 5 844578 3341 63650808
Enterovirus test positive 27.93 11.11 24 844559 216 63653933
Genital haemorrhage 27.92 11.11 19 844564 5503 63648646
Anal abscess 27.79 11.11 181 844402 7327 63646822
Onychomadesis 27.68 11.11 92 844491 2792 63651357
Engraft failure 27.66 11.11 37 844546 574 63653575
Oligohydramnios 27.61 11.11 4 844579 3120 63651029
Rash macular 27.54 11.11 189 844394 23496 63630653
Meningitis tuberculous 27.52 11.11 51 844532 1060 63653089
Cystitis 27.50 11.11 743 843840 41932 63612217
Acute promyelocytic leukaemia 27.48 11.11 58 844525 1330 63652819
Behaviour disorder 27.44 11.11 12 844571 4450 63649699
Tendonitis 27.39 11.11 395 844188 19887 63634262
Electrocardiogram T wave inversion 27.30 11.11 15 844568 4879 63649270
Fracture 27.24 11.11 370 844213 18385 63635764
Congestive hepatopathy 27.24 11.11 9 844574 3964 63650185
Limb operation 27.22 11.11 90 844493 2724 63651425
Mass 27.18 11.11 313 844270 14963 63639186
Stillbirth 27.16 11.11 7 844576 3626 63650523
Infected dermal cyst 27.12 11.11 42 844541 750 63653399
Left ventricular hypertrophy 27.09 11.11 52 844531 9454 63644695
Mucosal disorder 27.05 11.11 95 844488 2967 63651182
Homicidal ideation 26.93 11.11 5 844578 3252 63650897
Oliguria 26.88 11.11 99 844484 14477 63639672
Q fever 26.87 11.11 22 844561 184 63653965
Coronary artery bypass 26.83 11.11 22 844561 5793 63648356
Laryngitis 26.82 11.11 241 844342 10790 63643359
Underdose 26.74 11.11 213 844370 25616 63628533
Ovarian hyperstimulation syndrome 26.70 11.11 3 844580 2842 63651307
Post procedural infection 26.67 11.11 216 844367 9381 63644768
Graft versus host disease in liver 26.66 11.11 61 844522 1480 63652669
Respiratory tract infection 26.65 11.11 660 843923 36747 63617402
Photosensitivity reaction 26.59 11.11 359 844224 17814 63636335
Eosinophil count increased 26.59 11.11 95 844488 14017 63640132
Gastrointestinal pain 26.47 11.11 180 844403 7394 63646755
Paradoxical psoriasis 26.43 11.11 19 844564 128 63654021
Folate deficiency 26.40 11.11 88 844495 2675 63651474
Pulse absent 26.32 11.11 48 844535 8898 63645251
Myeloid leukaemia 26.28 11.11 36 844547 572 63653577
Medication error 26.24 11.11 478 844105 49488 63604661
Intestinal sepsis 26.24 11.11 37 844546 605 63653544
Accidental overdose 26.09 11.11 297 844286 33260 63620889
Arteriospasm coronary 26.07 11.11 20 844563 5445 63648704
Nervousness 26.06 11.11 254 844329 29302 63624847
Nephrolithiasis 26.04 11.11 753 843830 42930 63611219
Duodenal ulcer 26.00 11.11 99 844484 14336 63639813
Traumatic lung injury 25.89 11.11 77 844506 2199 63651950
Cutaneous tuberculosis 25.87 11.11 22 844561 195 63653954
Joint tuberculosis 25.86 11.11 19 844564 133 63654016
Gastrointestinal inflammation 25.84 11.11 154 844429 6041 63648108
Blood iron abnormal 25.81 11.11 51 844532 1114 63653035
Conduction disorder 25.77 11.11 4 844579 2964 63651185
Catheter site haemorrhage 25.72 11.11 14 844569 4577 63649572
Pruritus 25.69 11.11 3642 840941 308758 63345391
Laryngeal disorder 25.68 11.11 44 844539 858 63653291
Sudden cardiac death 25.68 11.11 14 844569 4573 63649576
Inadequate analgesia 25.59 11.11 10 844573 3968 63650181
Myoglobin blood increased 25.52 11.11 3 844580 2744 63651405
Alanine aminotransferase abnormal 25.46 11.11 166 844417 6722 63647427
Social avoidant behaviour 25.38 11.11 14 844569 4543 63649606
Breast cancer female 25.37 11.11 133 844450 4970 63649179
Acute lymphocytic leukaemia 25.34 11.11 119 844464 4252 63649897
Viral haemorrhagic cystitis 25.34 11.11 62 844521 1573 63652576
Meningitis haemophilus 25.33 11.11 10 844573 13 63654136
Cerebral salt-wasting syndrome 25.31 11.11 17 844566 101 63654048
Alcohol poisoning 25.29 11.11 12 844571 4243 63649906
High density lipoprotein decreased 25.25 11.11 10 844573 3936 63650213
Coronary artery stenosis 25.22 11.11 70 844513 11178 63642971
Hypertensive crisis 25.19 11.11 138 844445 18110 63636039
Extrasystoles 25.18 11.11 30 844553 6628 63647521
Herpes zoster oticus 25.17 11.11 28 844555 355 63653794
Central nervous system leukaemia 25.05 11.11 28 844555 357 63653792
Mitochondrial toxicity 25.03 11.11 3 844580 2703 63651446
Sinus arrest 25.01 11.11 5 844578 3085 63651064
Chronic graft versus host disease in liver 24.97 11.11 34 844549 537 63653612
Mixed liver injury 24.97 11.11 21 844562 5460 63648689
Craniosynostosis 24.97 11.11 15 844568 71 63654078
No adverse event 24.95 11.11 246 844337 28315 63625834
Akinesia 24.88 11.11 5 844578 3074 63651075
T-cell lymphoma 24.88 11.11 51 844532 1145 63653004
Tongue oedema 24.85 11.11 25 844558 5965 63648184
Logorrhoea 24.82 11.11 11 844572 4048 63650101
Sickle cell anaemia with crisis 24.82 11.11 20 844563 5312 63648837
Abortion spontaneous 24.82 11.11 210 844373 24933 63629216
Hidradenitis 24.81 11.11 77 844506 2252 63651897
Hyperammonaemic encephalopathy 24.81 11.11 11 844572 4047 63650102
Haemorrhoids 24.81 11.11 198 844385 23803 63630346
Pleural fibrosis 24.77 11.11 112 844471 3938 63650211
Interferon gamma release assay positive 24.72 11.11 11 844572 23 63654126
Product residue present 24.71 11.11 6 844577 3236 63650913
Sexual dysfunction 24.64 11.11 29 844554 6442 63647707
Pancreatitis 24.61 11.11 593 843990 59014 63595135
Red blood cells urine positive 24.59 11.11 14 844569 4464 63649685
Chronic recurrent multifocal osteomyelitis 24.53 11.11 14 844569 59 63654090
Blood sodium increased 24.51 11.11 13 844570 4313 63649836
Pregnancy 24.51 11.11 166 844417 20699 63633450
Paraplegia 24.41 11.11 120 844463 4370 63649779
Incontinence 24.34 11.11 79 844504 12002 63642147
Ataxia 24.33 11.11 179 844404 21905 63632244
Iron deficiency anaemia 24.31 11.11 177 844406 21712 63632437
Prescribed overdose 24.26 11.11 161 844422 20170 63633979
Pulmonary nocardiosis 24.26 11.11 39 844544 720 63653429
Pulmonary arteriopathy 24.23 11.11 16 844567 92 63654057
Self-injurious ideation 24.21 11.11 6 844577 3191 63650958
Thyroid cancer 24.13 11.11 110 844473 3881 63650268
Mycobacterium avium complex infection 24.12 11.11 109 844474 3831 63650318
Bone density abnormal 24.10 11.11 85 844498 2660 63651489
Meniscus injury 24.10 11.11 146 844437 5761 63648388
Tropical infectious disease 24.02 11.11 12 844571 36 63654113
Hepatitis acute 24.00 11.11 92 844491 13297 63640852
Nasopharyngeal cancer 23.97 11.11 19 844564 151 63653998
Decubitus ulcer 23.94 11.11 92 844491 13287 63640862
Trigger finger 23.94 11.11 101 844482 3444 63650705
Cushingoid 23.84 11.11 176 844407 7427 63646722
Metabolic disorder 23.83 11.11 40 844543 7657 63646492
Liver function test abnormal 23.82 11.11 978 843605 58423 63595726
Protein urine present 23.81 11.11 51 844532 8905 63645244
Oesophageal squamous cell carcinoma 23.73 11.11 30 844553 439 63653710
Eye infection 23.72 11.11 205 844378 9076 63645073
Hepatosplenomegaly 23.70 11.11 135 844448 5208 63648941
Tonsil cancer 23.70 11.11 44 844539 916 63653233
Cartilage atrophy 23.67 11.11 19 844564 154 63653995
Hyperventilation 23.62 11.11 33 844550 6807 63647342
Blood urine present 23.55 11.11 142 844441 18198 63635951
Anaesthetic complication 23.51 11.11 3 844580 2576 63651573
Bone density decreased 23.47 11.11 216 844367 9736 63644413
Blood phosphorus decreased 23.45 11.11 24 844559 5681 63648468
Heavy chain disease 23.44 11.11 7 844576 0 63654149
Osteophyte fracture 23.44 11.11 7 844576 0 63654149
Septic arthritis staphylococcal 23.33 11.11 37 844546 675 63653474
Diverticular perforation 23.31 11.11 132 844451 5081 63649068
Taste disorder 23.22 11.11 56 844527 9377 63644772
Vascular device infection 23.21 11.11 28 844555 6152 63647997
Rhinitis allergic 23.19 11.11 44 844539 8034 63646115
Blood albumin decreased 23.12 11.11 171 844412 20902 63633247
Hyperkinesia 23.12 11.11 3 844580 2543 63651606
Serum procollagen type III N-terminal propeptide increased 23.11 11.11 12 844571 40 63654109
Malnutrition 23.05 11.11 151 844432 18974 63635175
Tendon disorder 23.04 11.11 152 844431 6180 63647969
Catheter site pain 23.03 11.11 15 844568 4447 63649702
Catheterisation cardiac 23.03 11.11 18 844565 4855 63649294
Systemic infection 23.03 11.11 14 844569 4307 63649842
Urine abnormality 23.03 11.11 38 844545 7324 63646825
Tuberculosis of central nervous system 23.02 11.11 28 844555 393 63653756
Meningitis aseptic 22.98 11.11 141 844442 5589 63648560
Viral infection 22.94 11.11 628 843955 35512 63618637
Bloody discharge 22.88 11.11 56 844527 1421 63652728
Glioblastoma multiforme 22.88 11.11 48 844535 1096 63653053
PCO2 decreased 22.86 11.11 5 844578 2897 63651252
Cytomegalovirus test positive 22.84 11.11 130 844453 5014 63649135
Eye infection toxoplasmal 22.83 11.11 30 844553 457 63653692
Rales 22.81 11.11 112 844471 15117 63639032
N-terminal prohormone brain natriuretic peptide increased 22.80 11.11 9 844574 3550 63650599
Growth failure 22.79 11.11 21 844562 209 63653940
Legionella infection 22.79 11.11 37 844546 689 63653460
Follicular lymphoma 22.71 11.11 18 844565 143 63654006
Surgery 22.61 11.11 506 844077 27707 63626442
Pericardial haemorrhage 22.61 11.11 13 844570 4123 63650026
Application site pruritus 22.59 11.11 9 844574 3530 63650619
Multiple fractures 22.59 11.11 146 844437 5894 63648255
Salivary gland cancer 22.57 11.11 27 844556 372 63653777
Red blood cell sedimentation rate decreased 22.56 11.11 21 844562 212 63653937
Nodal rhythm 22.54 11.11 5 844578 2869 63651280
Incorrect disposal of product 22.54 11.11 40 844543 803 63653346
Middle lobe syndrome 22.50 11.11 11 844572 31 63654118
Screaming 22.49 11.11 9 844574 3520 63650629
Antibody test positive 22.41 11.11 76 844507 2331 63651818
Bursitis infective staphylococcal 22.41 11.11 14 844569 72 63654077
Scleroderma renal crisis 22.41 11.11 27 844556 375 63653774
Spinal fusion surgery 22.35 11.11 101 844482 3550 63650599
Enterovirus infection 22.31 11.11 55 844528 1402 63652747
Cytology abnormal 22.29 11.11 25 844558 320 63653829
Gastritis 22.29 11.11 408 844175 42210 63611939
Hair follicle tumour benign 22.28 11.11 28 844555 407 63653742
Hip fracture 22.20 11.11 237 844346 26862 63627287
Encephalitis brain stem 22.19 11.11 20 844563 193 63653956
Tongue neoplasm malignant stage unspecified 22.18 11.11 42 844541 888 63653261
Empyema 22.15 11.11 101 844482 3564 63650585
Angle closure glaucoma 22.14 11.11 4 844579 2653 63651496
Dissociation 22.13 11.11 6 844577 3005 63651144
Foetal death 22.13 11.11 27 844556 5903 63648246
Tumour haemorrhage 22.11 11.11 9 844574 3484 63650665
Lipase increased 22.10 11.11 105 844478 14297 63639852
Multiple sclerosis 22.10 11.11 151 844432 18790 63635359
Nephrogenic anaemia 21.99 11.11 8 844575 3317 63650832
Antithrombin III decreased 21.98 11.11 28 844555 413 63653736
Mucosal necrosis 21.96 11.11 15 844568 92 63654057
Post transplant lymphoproliferative disorder 21.93 11.11 206 844377 9338 63644811
Rash morbilliform 21.86 11.11 21 844562 5120 63649029
Crystal nephropathy 21.80 11.11 50 844533 1215 63652934
Psoriasis area severity index increased 21.71 11.11 15 844568 94 63654055
Fusarium infection 21.71 11.11 57 844526 1512 63652637
Tooth disorder 21.64 11.11 413 844170 21989 63632160
Catheter site erythema 21.57 11.11 19 844564 4830 63649319
Thrombotic thrombocytopenic purpura 21.55 11.11 28 844555 5956 63648193
Breast abscess 21.45 11.11 46 844537 1067 63653082
Rheumatoid factor 21.44 11.11 16 844567 115 63654034
Linear IgA disease 21.41 11.11 5 844578 2769 63651380
Solar urticaria 21.40 11.11 13 844570 63 63654086
Gastrointestinal toxicity 21.37 11.11 131 844452 5191 63648958
Muscular weakness 21.36 11.11 1408 843175 125930 63528219
Actinomycotic pulmonary infection 21.29 11.11 10 844573 25 63654124
Haematopoietic neoplasm 21.27 11.11 14 844569 80 63654069
Injection site hypersensitivity 21.23 11.11 59 844524 1620 63652529
Restless legs syndrome 21.21 11.11 134 844449 16982 63637167
Cerebrosclerosis 21.15 11.11 9 844574 16 63654133
Tibia fracture 21.12 11.11 120 844463 4625 63649524
Anticonvulsant drug level increased 21.11 11.11 3 844580 2374 63651775
Overlap syndrome 21.08 11.11 36 844547 700 63653449
Inflammatory bowel disease 21.02 11.11 116 844467 4422 63649727
Varicella zoster pneumonia 20.99 11.11 15 844568 100 63654049
Extra dose administered 20.97 11.11 35 844548 6715 63647434
Cerebral venous thrombosis 20.93 11.11 75 844508 2366 63651783
Cholestatic liver injury 20.93 11.11 11 844572 3668 63650481
Human herpesvirus 6 infection 20.91 11.11 118 844465 4536 63649613
Diabetic metabolic decompensation 20.89 11.11 5 844578 2723 63651426
Exposure to communicable disease 20.89 11.11 29 844554 467 63653682
Purpura 20.87 11.11 136 844447 17110 63637039
Kidney infection 20.86 11.11 339 844244 17499 63636650
Lacunar infarction 20.84 11.11 25 844558 5507 63648642
Blister 20.82 11.11 1277 843306 79690 63574459
Prostatic specific antigen increased 20.79 11.11 53 844530 8707 63645442
Infiltration anaesthesia 20.78 11.11 17 844566 142 63654007
Hot flush 20.76 11.11 454 844129 45781 63608368
Eructation 20.75 11.11 57 844526 9134 63645015
Polyomavirus-associated nephropathy 20.74 11.11 20 844563 4868 63649281
Aortic stenosis 20.72 11.11 32 844551 6333 63647816
Anticoagulation drug level above therapeutic 20.70 11.11 7 844576 3038 63651111
Increased appetite 20.69 11.11 66 844517 10080 63644069
Anion gap increased 20.68 11.11 7 844576 3037 63651112
Nystagmus 20.65 11.11 56 844527 9012 63645137
Low density lipoprotein increased 20.64 11.11 44 844539 7696 63646453
Capnocytophaga infection 20.64 11.11 13 844570 68 63654081
Meningitis noninfective 20.60 11.11 12 844571 53 63654096
Post-traumatic stress disorder 20.56 11.11 15 844568 4190 63649959
Atelectasis 20.54 11.11 243 844340 27023 63627126
Neck deformity 20.51 11.11 59 844524 1653 63652496
Osteosarcoma recurrent 20.50 11.11 10 844573 28 63654121
Laryngitis fungal 20.50 11.11 16 844567 124 63654025
Tongue ulceration 20.50 11.11 98 844485 3528 63650621
Prosthesis user 20.49 11.11 13 844570 69 63654080
Ankle arthroplasty 20.48 11.11 40 844543 866 63653283
Blood pressure systolic increased 20.47 11.11 817 843766 48636 63605513
Stress cardiomyopathy 20.47 11.11 58 844525 9199 63644950
Tongue neoplasm 20.43 11.11 12 844571 54 63654095
CSF myelin basic protein increased 20.43 11.11 8 844575 10 63654139
Hypertonia 20.39 11.11 32 844551 6293 63647856
Radiation pneumonitis 20.38 11.11 9 844574 3319 63650830
Hyperparathyroidism 20.38 11.11 6 844577 2846 63651303
Scab 20.37 11.11 194 844389 8828 63645321
Blood glucose abnormal 20.33 11.11 55 844528 8858 63645291
Pulmonary congestion 20.31 11.11 207 844376 23673 63630476
Sweat gland tumour 20.31 11.11 29 844554 480 63653669
Malignant neoplasm of conjunctiva 20.29 11.11 11 844572 41 63654108
Accidental exposure to product 20.24 11.11 234 844349 26130 63628019
Jaundice cholestatic 20.16 11.11 53 844530 8617 63645532
Stomatitis haemorrhagic 20.11 11.11 14 844569 89 63654060
Arthritis viral 20.09 11.11 6 844577 0 63654149
Oropharyngeal discolouration 20.09 11.11 6 844577 0 63654149
Adactyly 20.09 11.11 6 844577 0 63654149
Foetal methotrexate syndrome 20.09 11.11 6 844577 0 63654149
Insurance issue 20.09 11.11 6 844577 2820 63651329
Idiopathic pneumonia syndrome 20.05 11.11 30 844553 519 63653630
Blood calcium increased 20.03 11.11 52 844531 8490 63645659
Mass excision 20.01 11.11 22 844561 275 63653874
Tearfulness 19.97 11.11 19 844564 4654 63649495
Therapy cessation 19.95 11.11 302 844281 32187 63621962
Renal artery stenosis 19.88 11.11 7 844576 2962 63651187
Cell-mediated immune deficiency 19.86 11.11 14 844569 91 63654058
Gynaecomastia 19.82 11.11 30 844553 5986 63648163
Staphylococcal sepsis 19.78 11.11 257 844326 12642 63641507
Electrocardiogram ST segment depression 19.77 11.11 17 844566 4372 63649777
Neutropenia 19.75 11.11 2793 841790 236831 63417318
Loose body in joint 19.75 11.11 47 844536 1171 63652978
Subcutaneous abscess 19.74 11.11 159 844424 6894 63647255
Ocular hypertension 19.73 11.11 48 844535 1213 63652936
Procedural haemorrhage 19.73 11.11 16 844567 4236 63649913
Gait inability 19.70 11.11 709 843874 41659 63612490
Quadriplegia 19.69 11.11 85 844498 2928 63651221
Cardiac pacemaker insertion 19.68 11.11 22 844561 5001 63649148
Pachymeningitis 19.67 11.11 20 844563 227 63653922
Multiple drug therapy 19.66 11.11 3 844580 2251 63651898
Burkitt's lymphoma 19.65 11.11 15 844568 112 63654037
Small intestinal haemorrhage 19.63 11.11 13 844570 3820 63650329
Granulomatous pneumonitis 19.62 11.11 12 844571 59 63654090
Raoultella ornithinolytica infection 19.62 11.11 8 844575 12 63654137
Colon cancer 19.62 11.11 254 844329 12485 63641664
Focal segmental glomerulosclerosis 19.61 11.11 7 844576 2937 63651212
Plantar fasciitis 19.56 11.11 81 844502 2739 63651410
Osteosarcoma metastatic 19.52 11.11 11 844572 45 63654104
Intervertebral discitis 19.50 11.11 101 844482 3756 63650393
Bladder transitional cell carcinoma 19.48 11.11 71 844512 2259 63651890
Ileal stenosis 19.47 11.11 66 844517 2024 63652125
Local reaction 19.45 11.11 28 844555 467 63653682
Fanconi syndrome acquired 19.42 11.11 4 844579 2417 63651732
Ecchymosis 19.38 11.11 106 844477 13916 63640233
Tender joint count increased 19.34 11.11 15 844568 115 63654034
Double stranded DNA antibody positive 19.31 11.11 25 844558 375 63653774
Guttate psoriasis 19.26 11.11 25 844558 376 63653773
Ependymoma malignant 19.24 11.11 8 844575 13 63654136
Injection site vesicles 19.24 11.11 77 844506 2563 63651586
Hepatitis B 19.23 11.11 170 844413 7575 63646574
Cell marker increased 19.18 11.11 32 844551 610 63653539
Splenic infection fungal 19.17 11.11 14 844569 97 63654052
Injection site induration 19.15 11.11 190 844393 8742 63645407
Electrocardiogram T wave abnormal 19.14 11.11 10 844573 3346 63650803
Benign prostatic hyperplasia 19.12 11.11 59 844524 9106 63645043
Blood cholesterol increased 19.10 11.11 820 843763 49246 63604903
Apnoea 19.08 11.11 71 844512 10351 63643798
Disease susceptibility 19.08 11.11 20 844563 236 63653913
Localised oedema 19.08 11.11 41 844542 7150 63646999
Pharyngeal ulceration 19.07 11.11 37 844546 797 63653352
Haemorrhagic transformation stroke 19.06 11.11 4 844579 2385 63651764
Listeriosis 19.05 11.11 63 844520 1907 63652242
Aspergillus infection 19.05 11.11 311 844272 16068 63638081
Squamous cell carcinoma of the oral cavity 19.03 11.11 27 844556 444 63653705
Wernicke's encephalopathy 19.02 11.11 9 844574 23 63654126
Malignant respiratory tract neoplasm 19.02 11.11 9 844574 23 63654126
Stupor 19.02 11.11 31 844552 6004 63648145
Lip oedema 18.97 11.11 24 844559 5165 63648984
Application site erythema 18.97 11.11 20 844563 4669 63649480
Mycotic allergy 18.95 11.11 41 844542 957 63653192
Bradyarrhythmia 18.91 11.11 13 844570 3745 63650404
Sinus node dysfunction 18.90 11.11 38 844545 6790 63647359
Plasmablastic lymphoma 18.87 11.11 25 844558 384 63653765
Precancerous cells present 18.86 11.11 41 844542 960 63653189
Protein total decreased 18.85 11.11 48 844535 7888 63646261
Acute monocytic leukaemia 18.80 11.11 26 844557 417 63653732
Leukodystrophy 18.76 11.11 9 844574 24 63654125
Acute myelomonocytic leukaemia 18.71 11.11 21 844562 269 63653880
Skin neoplasm excision 18.69 11.11 38 844545 848 63653301
Sinus congestion 18.65 11.11 295 844288 15144 63639005
Gingivitis ulcerative 18.63 11.11 20 844563 243 63653906
Intertrigo 18.58 11.11 31 844552 591 63653558
Cytotoxic oedema 18.56 11.11 22 844561 300 63653849
Perineal infection 18.53 11.11 23 844560 330 63653819
Endometrial adenocarcinoma 18.51 11.11 39 844544 893 63653256
Refractoriness to platelet transfusion 18.51 11.11 14 844569 103 63654046
Dermatitis psoriasiform 18.46 11.11 66 844517 2080 63652069
Haemolysis 18.43 11.11 78 844505 10961 63643188
Oesophageal stenosis 18.43 11.11 99 844484 3735 63650414
Skin infection 18.42 11.11 288 844295 14749 63639400
Catheter site pruritus 18.41 11.11 3 844580 2145 63652004
Lip and/or oral cavity cancer 18.40 11.11 28 844555 492 63653657
Myositis 18.40 11.11 132 844451 16245 63637904
Squamous cell carcinoma of the tongue 18.39 11.11 32 844551 632 63653517
Walking aid user 18.35 11.11 143 844440 6138 63648011
Pseudomonas test positive 18.33 11.11 54 844529 1534 63652615
Blood thyroid stimulating hormone decreased 18.29 11.11 25 844558 5205 63648944
T-cell type acute leukaemia 18.28 11.11 16 844567 148 63654001
Concomitant disease progression 18.27 11.11 10 844573 3259 63650890
Cryptococcosis 18.22 11.11 78 844505 2677 63651472
Diabetic nephropathy 18.21 11.11 6 844577 2648 63651501
Disseminated sporotrichosis 18.21 11.11 8 844575 16 63654133
Foetal exposure during pregnancy 18.21 11.11 19 844564 4457 63649692
Gliosis 18.20 11.11 24 844559 367 63653782
Psychiatric symptom 18.15 11.11 34 844549 6239 63647910
Subdural hygroma 18.13 11.11 26 844557 432 63653717
Palindromic rheumatism 18.13 11.11 22 844561 308 63653841
Cytopenia 18.08 11.11 294 844289 15177 63638972
Supraventricular extrasystoles 18.07 11.11 31 844552 5884 63648265
Injection site discomfort 18.06 11.11 106 844477 4135 63650014
Pneumonia viral 18.06 11.11 169 844414 7653 63646496
Bone sarcoma 18.03 11.11 13 844570 88 63654061
Cerebellar haemorrhage 18.03 11.11 6 844577 2631 63651518
Tachyarrhythmia 18.03 11.11 32 844551 5994 63648155
Exercise tolerance decreased 18.03 11.11 47 844536 7663 63646486
Brachiocephalic artery stenosis 18.02 11.11 9 844574 27 63654122
Transplant dysfunction 18.00 11.11 38 844545 6670 63647479
Euphoric mood 17.97 11.11 37 844546 6554 63647595
Blood phosphorus increased 17.96 11.11 23 844560 4923 63649226
Pulmonary granuloma 17.95 11.11 59 844524 1780 63652369
Immunosuppressant drug level increased 17.95 11.11 43 844540 7216 63646933
Red blood cell sedimentation rate 17.92 11.11 96 844487 3618 63650531
Ocular lymphoma 17.92 11.11 13 844570 89 63654060
Meningitis coccidioides 17.92 11.11 10 844573 40 63654109
Progressive multifocal leukoencephalopathy 17.91 11.11 337 844246 17895 63636254
Intussusception 17.90 11.11 38 844545 875 63653274
Anaplastic thyroid cancer 17.90 11.11 8 844575 17 63654132
Hyperthermia malignant 17.89 11.11 5 844578 2454 63651695
Nasal cavity cancer 17.87 11.11 16 844567 153 63653996
Haemoperitoneum 17.83 11.11 15 844568 3900 63650249
Osteosarcoma 17.79 11.11 21 844562 285 63653864
Heart rate decreased 17.79 11.11 887 843696 54180 63599969
Human bocavirus infection 17.79 11.11 29 844554 542 63653607
Cervix carcinoma 17.78 11.11 59 844524 1789 63652360
Herpes simplex reactivation 17.77 11.11 20 844563 257 63653892
Vasoplegia syndrome 17.73 11.11 7 844576 2760 63651389
Infusion site pruritus 17.70 11.11 6 844577 2600 63651549
Large intestine anastomosis 17.69 11.11 13 844570 91 63654058
Secondary amyloidosis 17.69 11.11 14 844569 111 63654038
Pulmonary sarcoidosis 17.64 11.11 43 844540 1088 63653061
Papulopustular rosacea 17.60 11.11 8 844575 18 63654131
Tendon rupture 17.57 11.11 217 844366 10550 63643599
Coagulopathy 17.51 11.11 303 844280 31617 63622532
Acanthosis 17.49 11.11 24 844559 382 63653767
Osteonecrosis 17.49 11.11 489 844094 27740 63626409
Rectal cancer 17.46 11.11 78 844505 2728 63651421
Product preparation error 17.45 11.11 16 844567 3989 63650160
Furuncle 17.45 11.11 144 844439 6289 63647860
Eyelid oedema 17.43 11.11 92 844491 12187 63641962
Catheter site discharge 17.37 11.11 4 844579 2237 63651912
Colitis microscopic 17.37 11.11 161 844422 7271 63646878
Ischaemia 17.30 11.11 44 844539 7234 63646915
Arterial haemorrhage 17.26 11.11 4 844579 2227 63651922
Generalised oedema 17.23 11.11 182 844401 20671 63633478
Laryngospasm 17.22 11.11 12 844571 3433 63650716
Psychomotor skills impaired 17.19 11.11 15 844568 3830 63650319
Spondylitis 17.15 11.11 83 844500 3003 63651146
Synovial rupture 17.14 11.11 21 844562 297 63653852
Pertussis 17.06 11.11 35 844548 786 63653363
Infected bite 16.99 11.11 47 844536 1287 63652862
Hypoventilation 16.99 11.11 33 844550 5973 63648176
Immune recovery uveitis 16.97 11.11 7 844576 11 63654138
Troponin I increased 16.97 11.11 15 844568 3806 63650343
Infusion site reaction 16.96 11.11 63 844520 2023 63652126
Alcoholism 16.95 11.11 12 844571 3405 63650744
Gangrene 16.95 11.11 45 844538 7293 63646856
Facial paresis 16.94 11.11 116 844467 4776 63649373
Ventricular hypokinesia 16.94 11.11 49 844534 7720 63646429
Perineal necrosis 16.92 11.11 14 844569 119 63654030
Therapy partial responder 16.92 11.11 207 844376 10041 63644108
Cervical dysplasia 16.90 11.11 59 844524 1837 63652312
Orthopnoea 16.87 11.11 62 844521 9072 63645077
Plasma cell myeloma recurrent 16.83 11.11 17 844566 4048 63650101
Micturition urgency 16.81 11.11 74 844509 10285 63643864
Breath sounds abnormal 16.80 11.11 87 844496 11582 63642567
Amyloidosis 16.80 11.11 71 844512 2423 63651726
Cardiac murmur 16.77 11.11 86 844497 11477 63642672
Diplopia 16.71 11.11 248 844335 26517 63627632
Injection site papule 16.69 11.11 35 844548 799 63653350
Precursor T-lymphoblastic lymphoma/leukaemia 16.67 11.11 12 844571 81 63654068
Chromosomal deletion 16.67 11.11 12 844571 81 63654068
Perirectal abscess 16.67 11.11 57 844526 1756 63652393
Carotid artery stenosis 16.65 11.11 51 844532 7890 63646259
Extremity contracture 16.65 11.11 53 844530 1572 63652577
Skin bacterial infection 16.63 11.11 23 844560 369 63653780
Autoimmune lymphoproliferative syndrome 16.63 11.11 16 844567 169 63653980
HLA-B*27 positive 16.56 11.11 12 844571 82 63654067
Major depression 16.53 11.11 50 844533 7766 63646383
Pneumocystis jirovecii infection 16.52 11.11 68 844515 2293 63651856
Endotracheal intubation 16.46 11.11 16 844567 3879 63650270
Bone abscess 16.44 11.11 25 844558 439 63653710
Facial paralysis 16.43 11.11 344 844239 18622 63635527
Bone marrow transplant rejection 16.43 11.11 19 844564 252 63653897
Stress fracture 16.40 11.11 128 844455 5496 63648653
Deafness neurosensory 16.40 11.11 141 844442 6233 63647916
Accidental exposure to product by child 16.40 11.11 6 844577 2479 63651670
Middle insomnia 16.38 11.11 100 844483 12777 63641372
Haemarthrosis 16.35 11.11 27 844556 5202 63648947
Eczema 16.34 11.11 282 844301 29438 63624711
Acute psychosis 16.34 11.11 15 844568 3737 63650412
Hypersomnia 16.33 11.11 172 844411 19545 63634604
Pupillary reflex impaired 16.32 11.11 10 844573 3063 63651086
Wheelchair user 16.31 11.11 111 844472 4561 63649588
Infusion site haemorrhage 16.30 11.11 5 844578 2310 63651839
Hereditary angioedema 16.29 11.11 16 844567 3860 63650289
Bronchiectasis 16.26 11.11 268 844315 13872 63640277
Pyomyositis 16.25 11.11 27 844556 513 63653636
Cholesteatoma 16.23 11.11 13 844570 105 63654044
Graft versus host disease in eye 16.21 11.11 20 844563 285 63653864
Central nervous system lymphoma 16.21 11.11 59 844524 1876 63652273
Coronavirus infection 16.21 11.11 126 844457 5404 63648745
Steatohepatitis 16.18 11.11 34 844549 777 63653372
Device physical property issue 16.16 11.11 4 844579 2129 63652020
Application site rash 16.16 11.11 3 844580 1951 63652198
Peripheral T-cell lymphoma unspecified 16.14 11.11 29 844554 588 63653561
Sinusitis bacterial 16.14 11.11 42 844541 1108 63653041
Isosporiasis 16.14 11.11 13 844570 106 63654043
Stem cell transplant 16.14 11.11 89 844494 3392 63650757
Pain in jaw 16.13 11.11 408 844175 40347 63613802
Pterygium 16.11 11.11 20 844563 287 63653862
Hair colour changes 16.11 11.11 15 844568 3712 63650437
Skin fissures 16.08 11.11 206 844377 10100 63644049
Skin atrophy 16.06 11.11 115 844468 4805 63649344
Atrial thrombosis 16.01 11.11 10 844573 3032 63651117
Myxoid liposarcoma 16.01 11.11 6 844577 6 63654143
Tendon graft 16.01 11.11 6 844577 6 63654143
Diffuse large B-cell lymphoma stage II 16.00 11.11 12 844571 87 63654062
Androgenetic alopecia 16.00 11.11 15 844568 153 63653996
Contraindication to vaccination 15.99 11.11 17 844566 204 63653945
Blood lactate dehydrogenase increased 15.97 11.11 321 844262 32757 63621392
Tension 15.96 11.11 16 844567 3824 63650325
Bronchioloalveolar carcinoma 15.92 11.11 10 844573 52 63654097
Immune effector cell-associated neurotoxicity syndrome 15.92 11.11 7 844576 2588 63651561
Peritonsillar abscess 15.92 11.11 33 844550 747 63653402
Product storage error 15.91 11.11 254 844329 13064 63641085
Gastritis erosive 15.90 11.11 68 844515 9527 63644622
Scarlet fever 15.89 11.11 12 844571 88 63654061
Suicidal behaviour 15.89 11.11 9 844574 2878 63651271
Injection site haematoma 15.88 11.11 97 844486 3839 63650310
Pleural thickening 15.87 11.11 74 844509 2636 63651513
Meningitis enterococcal 15.79 11.11 12 844571 89 63654060
Purulent pericarditis 15.78 11.11 10 844573 53 63654096
Inflammatory pseudotumour 15.78 11.11 10 844573 53 63654096
Occult blood positive 15.74 11.11 37 844546 6250 63647899
Nodular melanoma 15.69 11.11 15 844568 157 63653992
Cranial nerve disorder 15.68 11.11 35 844548 835 63653314
Rotator cuff syndrome 15.65 11.11 234 844349 11873 63642276
Lower respiratory tract infection viral 15.64 11.11 37 844546 918 63653231
Ulcerative keratitis 15.59 11.11 81 844502 3016 63651133
Infectious thyroiditis 15.58 11.11 13 844570 112 63654037
Breast mass 15.57 11.11 121 844462 5189 63648960
Pancreatic calcification 15.56 11.11 17 844566 211 63653938
Hepatocellular carcinoma 15.54 11.11 57 844526 8346 63645803
Vascular purpura 15.52 11.11 7 844576 2549 63651600
Peripheral coldness 15.50 11.11 109 844474 13475 63640674
Lymphocyte percentage decreased 15.49 11.11 23 844560 4626 63649523
Feeling jittery 15.48 11.11 79 844504 10556 63643593
Pericarditis tuberculous 15.48 11.11 12 844571 92 63654057
Chronic myeloid leukaemia 15.46 11.11 86 844497 3288 63650861
Rotator cuff repair 15.46 11.11 49 844534 1450 63652699
Cervix carcinoma stage 0 15.43 11.11 17 844566 213 63653936
Device alarm issue 15.42 11.11 3 844580 1887 63652262
Ear infection bacterial 15.41 11.11 9 844574 40 63654109
Diabetic retinopathy 15.41 11.11 9 844574 2830 63651319
Intraventricular haemorrhage 15.40 11.11 19 844564 4134 63650015
Myelosuppression 15.38 11.11 415 844168 23415 63630734
Venous injury 15.37 11.11 28 844555 574 63653575
Fracture delayed union 15.36 11.11 59 844524 1926 63652223
Self-medication 15.33 11.11 19 844564 4126 63650023
Hypokinesia 15.32 11.11 141 844442 16455 63637694
Cytogenetic abnormality 15.31 11.11 39 844544 1015 63653134
Myelomalacia 15.31 11.11 13 844570 115 63654034
Cheilitis 15.30 11.11 109 844474 4547 63649602
Post transplant distal limb syndrome 15.28 11.11 26 844557 504 63653645
Spinal meningioma benign 15.27 11.11 12 844571 94 63654055
Herpes simplex oesophagitis 15.27 11.11 18 844565 244 63653905
Dermatomyositis 15.26 11.11 75 844508 2731 63651418
Vasculitic rash 15.26 11.11 59 844524 1932 63652217
Prostate cancer 15.23 11.11 353 844230 19442 63634707
Graft versus host disease in lung 15.23 11.11 33 844550 771 63653378
Pneumonitis chemical 15.22 11.11 21 844562 336 63653813
Oesophageal varices haemorrhage 15.22 11.11 15 844568 3614 63650535
Malignant melanoma stage I 15.22 11.11 13 844570 116 63654033
Bipolar disorder 15.21 11.11 42 844541 6719 63647430
Hepatic candidiasis 15.20 11.11 11 844572 75 63654074
Drug-device interaction 15.20 11.11 11 844572 75 63654074
Metatarsalgia 15.19 11.11 17 844566 217 63653932
Flank pain 15.18 11.11 137 844446 16052 63638097
Squamous cell carcinoma of the cervix 15.18 11.11 16 844567 190 63653959
Cardiac valve disease 15.17 11.11 28 844555 5167 63648982
Renal cell carcinoma 15.17 11.11 134 844449 5970 63648179
Growth retardation 15.17 11.11 50 844533 1511 63652638
Herpes ophthalmic 15.16 11.11 43 844540 1195 63652954
Myopathy 15.14 11.11 153 844430 17527 63636622
Trichosporon infection 15.09 11.11 35 844548 857 63653292
Galactorrhoea 15.08 11.11 12 844571 3207 63650942
Bladder transitional cell carcinoma recurrent 15.07 11.11 14 844569 141 63654008
Product prescribing issue 15.06 11.11 5 844578 2196 63651953
Bursa disorder 15.05 11.11 16 844567 192 63653957
Hypertriglyceridaemia 15.04 11.11 218 844365 10987 63643162
Intestinal polyp 15.04 11.11 53 844530 1658 63652491
Anti-cyclic citrullinated peptide antibody 15.01 11.11 46 844537 1336 63652813
Arthroscopy 15.01 11.11 25 844558 476 63653673
Incision site pain 15.00 11.11 8 844575 2646 63651503
Tinea versicolour 14.97 11.11 20 844563 310 63653839
Diffuse large B-cell lymphoma recurrent 14.96 11.11 81 844502 3065 63651084
Paranasal sinus hypersecretion 14.92 11.11 80 844503 3016 63651133
Feeling cold 14.92 11.11 219 844364 23459 63630690
Economic problem 14.91 11.11 5 844578 2182 63651967
Liver transplant 14.89 11.11 19 844564 4073 63650076
Nodal arrhythmia 14.88 11.11 3 844580 1840 63652309
Endocarditis bacterial 14.87 11.11 45 844538 1298 63652851
Femur fracture 14.85 11.11 567 844016 33568 63620581
Vulval cancer 14.84 11.11 23 844560 411 63653738
Elbow operation 14.83 11.11 18 844565 252 63653897
Snoring 14.80 11.11 24 844559 4658 63649491
Stress at work 14.79 11.11 37 844546 952 63653197
Antiphospholipid syndrome 14.77 11.11 50 844533 1532 63652617
Subcutaneous haematoma 14.76 11.11 7 844576 2476 63651673
Complicated appendicitis 14.76 11.11 9 844574 44 63654105
Uterine cancer 14.73 11.11 76 844507 2822 63651327
Heavy menstrual bleeding 14.73 11.11 95 844488 11982 63642167
Intra-abdominal haematoma 14.72 11.11 7 844576 2472 63651677
Product taste abnormal 14.71 11.11 4 844579 1999 63652150
Incorrect dosage administered 14.71 11.11 63 844520 2163 63651986
Combined immunodeficiency 14.69 11.11 12 844571 100 63654049
Pyopneumothorax 14.68 11.11 10 844573 61 63654088
Purulent discharge 14.68 11.11 122 844461 5339 63648810
Catheter site infection 14.66 11.11 33 844550 5660 63648489
Oral infection 14.65 11.11 110 844473 4667 63649482
Infection reactivation 14.62 11.11 59 844524 1971 63652178
Genital abscess 14.61 11.11 14 844569 147 63654002
Subacute combined cord degeneration 14.59 11.11 20 844563 318 63653831
Chloroma 14.59 11.11 30 844553 675 63653474
Monoclonal gammopathy 14.54 11.11 31 844552 716 63653433
Laryngitis viral 14.50 11.11 7 844576 19 63654130
Differential white blood cell count abnormal 14.50 11.11 3 844580 1807 63652342
Sluggishness 14.49 11.11 33 844550 5637 63648512
Alcohol withdrawal syndrome 14.42 11.11 3 844580 1800 63652349
Joint surgery 14.41 11.11 18 844565 260 63653889
Mucosal infection 14.41 11.11 23 844560 422 63653727
Pyrexia 14.40 11.11 6863 837720 551781 63102368
Induced abortion failed 14.37 11.11 15 844568 176 63653973
Cryptococcus test positive 14.34 11.11 6 844577 10 63654139
Glottis carcinoma 14.34 11.11 6 844577 10 63654139
Hypermobility syndrome 14.32 11.11 25 844558 495 63653654
Histiocytic sarcoma 14.31 11.11 10 844573 64 63654085
Unintended pregnancy 14.28 11.11 12 844571 3122 63651027
Blood parathyroid hormone increased 14.28 11.11 12 844571 3122 63651027
Abdominal pain lower 14.28 11.11 252 844331 26217 63627932
Ligament calcification 14.25 11.11 16 844567 205 63653944
Postoperative wound infection 14.24 11.11 202 844381 10134 63644015
Soft tissue swelling 14.21 11.11 39 844544 1063 63653086
Cauda equina syndrome 14.18 11.11 39 844544 1064 63653085
Norovirus test positive 14.18 11.11 23 844560 428 63653721
PO2 decreased 14.17 11.11 9 844574 2704 63651445
Abortion induced 14.14 11.11 40 844543 6348 63647801
Lentigo 14.14 11.11 23 844560 429 63653720
Presbyacusis 14.13 11.11 69 844514 2506 63651643
Thyroiditis 14.06 11.11 16 844567 3608 63650541
Plasmacytoma 14.05 11.11 18 844565 3852 63650297
Malignant melanoma in situ 14.00 11.11 54 844529 1766 63652383
Loss of libido 13.96 11.11 7 844576 2397 63651752
Hyperphosphataemia 13.95 11.11 19 844564 3962 63650187
Petit mal epilepsy 13.93 11.11 28 844555 5004 63649145
Blood chloride increased 13.93 11.11 26 844557 4777 63649372
Cytomegalovirus enteritis 13.91 11.11 29 844554 659 63653490
Pharyngeal inflammation 13.91 11.11 35 844548 904 63653245
Anaplastic large cell lymphoma T- and null-cell types 13.88 11.11 12 844571 109 63654040
Apathy 13.88 11.11 88 844495 11144 63643005
Muscle swelling 13.87 11.11 30 844553 700 63653449
Scedosporium infection 13.87 11.11 42 844541 1212 63652937
Human herpesvirus 8 infection 13.86 11.11 38 844545 1035 63653114
Intestinal malrotation 13.86 11.11 5 844578 4 63654145
Congenital foot malformation 13.86 11.11 5 844578 4 63654145
Neutrophil percentage increased 13.85 11.11 23 844560 4422 63649727
Limb mass 13.84 11.11 77 844506 2944 63651205
Parakeratosis 13.83 11.11 20 844563 335 63653814
Herpes zoster meningitis 13.83 11.11 13 844570 133 63654016
Salivary gland neoplasm 13.82 11.11 11 844572 88 63654061
Lipoma 13.80 11.11 69 844514 2530 63651619
Hepatitis C 13.77 11.11 86 844497 10929 63643220
Antisynthetase syndrome 13.76 11.11 13 844570 134 63654015
Rhonchi 13.75 11.11 15 844568 3448 63650701
Diarrhoea haemorrhagic 13.74 11.11 215 844368 11012 63643137
Leptotrichia infection 13.73 11.11 9 844574 51 63654098
Genital infection 13.73 11.11 9 844574 51 63654098
Anal inflammation 13.73 11.11 23 844560 440 63653709
Eyelid exfoliation 13.71 11.11 12 844571 111 63654038
Night sweats 13.66 11.11 590 843993 35456 63618693
Liver sarcoidosis 13.66 11.11 6 844577 12 63654137
Pathogen resistance 13.66 11.11 102 844481 12441 63641708
Oesophagitis 13.65 11.11 200 844383 21430 63632719
Biliary dyskinesia 13.63 11.11 7 844576 2365 63651784
Nocardiosis 13.63 11.11 108 844475 4659 63649490
Subdural abscess 13.60 11.11 9 844574 52 63654097
Hypergammaglobulinaemia 13.59 11.11 28 844555 631 63653518
Infusion site extravasation 13.57 11.11 45 844538 6792 63647357
Carpal tunnel decompression 13.55 11.11 24 844559 481 63653668
Adenoviral hepatitis 13.55 11.11 23 844560 445 63653704
Bronchiolitis obliterans syndrome 13.54 11.11 17 844566 247 63653902
Syringe issue 13.52 11.11 22 844561 4264 63649885
Follicle centre lymphoma, follicular grade I, II, III 13.50 11.11 10 844573 71 63654078
Renal disorder 13.47 11.11 356 844227 35009 63619140
Overwork 13.46 11.11 9 844574 53 63654096
Essential hypertension 13.46 11.11 30 844553 5164 63648985
Lichen myxoedematosus 13.46 11.11 8 844575 37 63654112
Resuscitation 13.45 11.11 5 844578 2046 63652103
Acute interstitial pneumonitis 13.44 11.11 37 844546 1010 63653139
Meningitis chemical 13.43 11.11 15 844568 191 63653958
Encephalopathy 13.43 11.11 631 843952 58188 63595961
Red cell distribution width decreased 13.42 11.11 38 844545 1055 63653094
Food allergy 13.40 11.11 55 844528 7796 63646353
Blau syndrome 13.40 11.11 4 844579 0 63654149
Myocarditis bacterial 13.40 11.11 4 844579 0 63654149
Peripheral T-cell lymphoma unspecified stage II 13.40 11.11 4 844579 0 63654149
Necrotising fasciitis staphylococcal 13.40 11.11 4 844579 0 63654149
Oral toxicity 13.40 11.11 4 844579 0 63654149
Leukaemia monocytic 13.40 11.11 4 844579 0 63654149
Mucinous breast carcinoma 13.40 11.11 4 844579 0 63654149
Respiratory tract ulceration 13.40 11.11 4 844579 0 63654149
Torus fracture 13.39 11.11 10 844573 72 63654077
Carbon dioxide decreased 13.37 11.11 12 844571 3023 63651126
Gastrointestinal sounds abnormal 13.36 11.11 27 844556 4816 63649333
Bladder neck operation 13.34 11.11 5 844578 5 63654144
Spinal rod insertion 13.34 11.11 5 844578 5 63654144
Wound infection 13.34 11.11 271 844312 14593 63639556
Hyperkeratosis 13.31 11.11 140 844443 6541 63647608
Erythema induratum 13.30 11.11 14 844569 166 63653983
Respiratory rate decreased 13.30 11.11 24 844559 4467 63649682
Acral lentiginous melanoma 13.29 11.11 8 844575 38 63654111
Hypogammaglobulinaemia 13.29 11.11 199 844384 10100 63644049
Pseudopolyp 13.28 11.11 21 844562 382 63653767
Portal fibrosis 13.28 11.11 26 844557 564 63653585
Blood creatine phosphokinase MB increased 13.27 11.11 9 844574 2612 63651537
Vaginal infection 13.27 11.11 110 844473 4810 63649339
Extradural abscess 13.27 11.11 40 844543 1151 63652998
Back disorder 13.27 11.11 194 844389 9796 63644353
Tic 13.26 11.11 9 844574 2610 63651539
Dyslipidaemia 13.25 11.11 69 844514 9173 63644976
Sleep disorder 13.24 11.11 930 843653 58779 63595370
Retroperitoneal haematoma 13.23 11.11 26 844557 4685 63649464
Lung abscess 13.22 11.11 86 844497 3480 63650669
Pulmonary function test decreased 13.19 11.11 42 844541 6419 63647730
Post procedural inflammation 13.17 11.11 10 844573 74 63654075
Large intestinal stenosis 13.16 11.11 65 844518 2372 63651777
Infectious pleural effusion 13.15 11.11 73 844510 2789 63651360
Urine output increased 13.14 11.11 4 844579 1857 63652292
Stenotrophomonas infection 13.13 11.11 77 844506 3003 63651146
Discouragement 13.08 11.11 30 844553 729 63653420
Dermatitis allergic 13.08 11.11 274 844309 14835 63639314
Hypertension 13.07 11.11 3102 841481 256159 63397990
Frequent bowel movements 13.05 11.11 323 844260 17982 63636167
Hydronephrosis 13.05 11.11 120 844463 14005 63640144
Strongyloidiasis 13.01 11.11 77 844506 3013 63651136
Arthropod bite 13.00 11.11 140 844443 6581 63647568
Upper limb fracture 13.00 11.11 270 844313 14596 63639553
Premature rupture of membranes 12.99 11.11 18 844565 3726 63650423
Shoulder operation 12.98 11.11 59 844524 2079 63652070
Multifocal motor neuropathy 12.98 11.11 8 844575 40 63654109
Testicular seminoma (pure) 12.98 11.11 8 844575 40 63654109
Vaccination failure 12.98 11.11 33 844550 858 63653291
Feeling abnormal 12.97 11.11 1541 843042 132061 63522088
Dyspnoea paroxysmal nocturnal 12.95 11.11 5 844578 1999 63652150
Peripheral vascular disorder 12.95 11.11 50 844533 7211 63646938
Candida test positive 12.94 11.11 37 844546 1033 63653116
Psychogenic seizure 12.92 11.11 4 844579 1837 63652312
Pain of skin 12.92 11.11 186 844397 9361 63644788
Meningitis viral 12.91 11.11 51 844532 1687 63652462
Knee operation 12.90 11.11 103 844480 4454 63649695
Exposed bone in jaw 12.88 11.11 16 844567 3471 63650678
Tooth fracture 12.88 11.11 192 844391 9735 63644414
Joint fluid drainage 12.87 11.11 18 844565 292 63653857
Device use issue 12.84 11.11 4 844579 1829 63652320
Rhinocerebral mucormycosis 12.81 11.11 23 844560 466 63653683
Neck surgery 12.81 11.11 46 844537 1453 63652696
Hiatus hernia 12.78 11.11 184 844399 19773 63634376
Fontanelle bulging 12.77 11.11 6 844577 15 63654134
Cyclic neutropenia 12.77 11.11 6 844577 15 63654134
Soft tissue disorder 12.76 11.11 80 844503 3196 63650953
Streptococcal infection 12.75 11.11 152 844431 7327 63646822
Abnormal faeces 12.74 11.11 37 844546 5822 63648327
Atrial septal defect 12.72 11.11 3 844580 1650 63652499
Lupus vasculitis 12.71 11.11 23 844560 469 63653680
Herpes simplex meningoencephalitis 12.71 11.11 9 844574 59 63654090
Psoas abscess 12.69 11.11 33 844550 870 63653279
Bronchopleural fistula 12.67 11.11 26 844557 584 63653565
Hypertensive emergency 12.66 11.11 7 844576 2269 63651880
Granulomatous liver disease 12.65 11.11 40 844543 1182 63652967
Meningitis listeria 12.59 11.11 30 844553 748 63653401
Pneumonia 12.58 11.11 6904 837679 552672 63101477
Lymphocele 12.58 11.11 3 844580 1638 63652511
Central nervous system necrosis 12.56 11.11 17 844566 267 63653882
Phototherapy 12.54 11.11 7 844576 28 63654121
Tissue injury 12.53 11.11 8 844575 43 63654106
Injection site paraesthesia 12.53 11.11 24 844559 512 63653637
Adult T-cell lymphoma/leukaemia recurrent 12.51 11.11 6 844577 16 63654133
Haematochezia 12.50 11.11 726 843857 65647 63588502
Hypopnoea 12.50 11.11 14 844569 3180 63650969
Appetite disorder 12.50 11.11 43 844540 6418 63647731
Allergy to vaccine 12.49 11.11 13 844570 152 63653997
Rash erythematous 12.49 11.11 515 844068 48118 63606031
Tongue disorder 12.46 11.11 225 844358 11855 63642294
Atrial tachycardia 12.46 11.11 17 844566 3542 63650607
Arthritis enteropathic 12.46 11.11 16 844567 238 63653911
Squamous cell carcinoma of the vagina 12.46 11.11 5 844578 7 63654142
Vulvovaginitis streptococcal 12.46 11.11 5 844578 7 63654142
Atrial septal defect acquired 12.46 11.11 5 844578 7 63654142
Diabetic neuropathy 12.45 11.11 35 844548 5566 63648583
Cystic fibrosis 12.43 11.11 16 844567 3418 63650731
Adenocarcinoma of the cervix 12.43 11.11 13 844570 153 63653996
Investigation 12.42 11.11 7 844576 2245 63651904
Blood creatine increased 12.41 11.11 60 844523 8132 63646017
Extravasation 12.38 11.11 14 844569 3166 63650983
Demyelinating polyneuropathy 12.36 11.11 45 844538 1431 63652718
Injection site extravasation 12.36 11.11 161 844422 7925 63646224
Sebaceous gland infection 12.30 11.11 11 844572 105 63654044
Hepatic necrosis 12.30 11.11 63 844520 8410 63645739
Leukaemia 12.29 11.11 111 844472 4977 63649172
Bone marrow disorder 12.28 11.11 71 844512 2754 63651395
Carotid intima-media thickness increased 12.27 11.11 10 844573 83 63654066
Acquired claw toe 12.27 11.11 10 844573 83 63654066
Intervertebral disc compression 12.27 11.11 35 844548 976 63653173
Retinitis 12.26 11.11 57 844526 2028 63652121
Macrocytosis 12.26 11.11 64 844519 2388 63651761
Tuberculosis of eye 12.25 11.11 8 844575 45 63654104
Lung squamous cell carcinoma stage I 12.25 11.11 6 844577 17 63654132
Haematocolpos 12.25 11.11 8 844575 45 63654104
DNA antibody positive 12.23 11.11 17 844566 274 63653875
Bone marrow oedema 12.23 11.11 38 844545 1112 63653037
Inflammatory myofibroblastic tumour 12.23 11.11 13 844570 156 63653993
Intestinal stenosis 12.21 11.11 78 844505 3136 63651013
Device malfunction 12.21 11.11 160 844423 17473 63636676
Injection related reaction 12.21 11.11 27 844556 640 63653509
Myocardial necrosis marker increased 12.19 11.11 11 844572 2764 63651385
Cutaneous T-cell lymphoma stage I 12.18 11.11 7 844576 30 63654119
Vaginal haemorrhage 12.16 11.11 179 844404 19165 63634984
Conjunctival deposit 12.07 11.11 5 844578 8 63654141
Ear canal stenosis 12.07 11.11 5 844578 8 63654141
Troponin T increased 12.02 11.11 8 844575 2345 63651804
Device infusion issue 12.02 11.11 4 844579 1754 63652395
Silicosis 12.01 11.11 6 844577 18 63654131
Ossicle disorder 12.01 11.11 7 844576 31 63654118
Anal incontinence 12.01 11.11 134 844449 15062 63639087
Allogenic bone marrow transplantation therapy 12.01 11.11 7 844576 31 63654118
Neutrophilia 12.00 11.11 46 844537 6648 63647501
Hepatitis fulminant 11.98 11.11 42 844541 6232 63647917
Schizoaffective disorder 11.98 11.11 3 844580 1584 63652565
Gastroenteritis Escherichia coli 11.96 11.11 19 844564 347 63653802
Vitreous floaters 11.94 11.11 43 844540 6330 63647819
Bezoar 11.94 11.11 7 844576 2196 63651953
Right ventricular dysfunction 11.94 11.11 7 844576 2196 63651953
Bronchopulmonary aspergillosis 11.93 11.11 331 844252 18754 63635395
Foreign body sensation in eyes 11.92 11.11 4 844579 1745 63652404
Aortic valve incompetence 11.89 11.11 62 844521 8239 63645910
Stomatitis necrotising 11.86 11.11 14 844569 190 63653959
Implant site pain 11.86 11.11 5 844578 1895 63652254
Application site irritation 11.85 11.11 3 844580 1573 63652576
Discontinued product administered 11.85 11.11 8 844575 48 63654101
Metastatic bronchial carcinoma 11.84 11.11 15 844568 220 63653929
Tenosynovitis stenosans 11.83 11.11 54 844529 1906 63652243
Blood fibrinogen decreased 11.83 11.11 44 844539 1414 63652735
Cardiovascular disorder 11.79 11.11 142 844441 15739 63638410
Procedural pain 11.76 11.11 138 844445 15370 63638779
Blood culture positive 11.75 11.11 156 844427 7712 63646437
Thymus enlargement 11.75 11.11 11 844572 112 63654037
Peritonitis 11.73 11.11 244 844339 24779 63629370
Joint abscess 11.73 11.11 19 844564 353 63653796
Herpes dermatitis 11.73 11.11 10 844573 89 63654060
Nephrogenic diabetes insipidus 11.72 11.11 5 844578 1882 63652267
Vulval cancer stage III 11.71 11.11 5 844578 9 63654140
Inability to afford medication 11.71 11.11 5 844578 1881 63652268
Mucosal atrophy 11.71 11.11 9 844574 68 63654081
Internal haemorrhage 11.71 11.11 56 844527 7611 63646538
Torticollis 11.68 11.11 7 844576 2170 63651979
Blood uric acid increased 11.68 11.11 61 844522 8102 63646047
Optic ischaemic neuropathy 11.66 11.11 10 844573 2575 63651574
Dysphoria 11.66 11.11 25 844558 4363 63649786
Transplant evaluation 11.64 11.11 3 844580 1554 63652595
Persecutory delusion 11.63 11.11 23 844560 4135 63650014
Tetany 11.63 11.11 7 844576 2165 63651984
Candida infection 11.63 11.11 513 844070 30906 63623243
Device failure 11.62 11.11 37 844546 5655 63648494
Poor quality product administered 11.62 11.11 15 844568 3200 63650949
Erythema nodosum 11.61 11.11 91 844492 3913 63650236
Blood beta-D-glucan increased 11.56 11.11 23 844560 505 63653644
Oral mucosal roughening 11.56 11.11 6 844577 20 63654129
Chronic actinic dermatitis 11.56 11.11 6 844577 20 63654129
Gelatinous transformation of the bone marrow 11.56 11.11 6 844577 20 63654129
Medical device discomfort 11.55 11.11 3 844580 1546 63652603
Sinus arrhythmia 11.54 11.11 5 844578 1865 63652284
Fungaemia 11.52 11.11 87 844496 3698 63650451
Keratopathy 11.48 11.11 29 844554 751 63653398
Oxygen therapy 11.45 11.11 8 844575 2285 63651864
Infectious mononucleosis 11.41 11.11 49 844534 1684 63652465
Endometriosis 11.39 11.11 69 844514 2723 63651426
Loss of control of legs 11.38 11.11 4 844579 1695 63652454
Hamartoma 11.38 11.11 5 844578 10 63654139
Ureterocele 11.38 11.11 5 844578 10 63654139
Genital herpes zoster 11.38 11.11 5 844578 10 63654139
Diffuse alveolar damage 11.38 11.11 77 844506 3158 63650991
Methaemoglobinaemia 11.36 11.11 25 844558 4323 63649826
Pasteurella infection 11.36 11.11 7 844576 35 63654114
Herpes zoster infection neurological 11.35 11.11 12 844571 143 63654006
Cytomegalovirus gastrointestinal ulcer 11.35 11.11 8 844575 52 63654097
Brain injury 11.35 11.11 80 844503 9885 63644264
Lower respiratory tract congestion 11.34 11.11 72 844511 2889 63651260
Brain oedema 11.33 11.11 212 844371 21863 63632286
Pancreatolithiasis 11.32 11.11 17 844566 295 63653854
Nerve injury 11.32 11.11 152 844431 7533 63646616
Philadelphia chromosome positive 11.32 11.11 25 844558 592 63653557
Libido decreased 11.31 11.11 29 844554 4755 63649394
Infected seroma 11.31 11.11 9 844574 72 63654077
Ankle brachial index decreased 11.31 11.11 9 844574 72 63654077
Meningitis staphylococcal 11.30 11.11 10 844573 94 63654055
Necrotising fasciitis streptococcal 11.29 11.11 12 844571 144 63654005
CSF protein increased 11.28 11.11 36 844547 1069 63653080
Ovarian epithelial cancer 11.27 11.11 14 844569 201 63653948
Hypopituitarism 11.27 11.11 11 844572 2662 63651487
Otitis media acute 11.26 11.11 36 844547 1070 63653079
Pleocytosis 11.24 11.11 36 844547 1071 63653078
Rash pustular 11.24 11.11 187 844396 9698 63644451
Carbon dioxide increased 11.24 11.11 6 844577 1983 63652166
Bacillus test positive 11.22 11.11 10 844573 95 63654054
Cystitis bacterial 11.22 11.11 20 844563 403 63653746
Alopecia scarring 11.22 11.11 10 844573 95 63654054
Stoma site discharge 11.20 11.11 4 844579 1678 63652471
Paranasal sinus haemorrhage 11.20 11.11 4 844579 3 63654146
Tuberculin test false negative 11.20 11.11 4 844579 3 63654146
Varicella post vaccine 11.20 11.11 4 844579 3 63654146
Yersinia test positive 11.20 11.11 4 844579 3 63654146
Synovial fluid white blood cells positive 11.20 11.11 4 844579 3 63654146
Lower limb fracture 11.19 11.11 244 844339 13301 63640848
Aortic arteriosclerosis 11.19 11.11 55 844528 7421 63646728
Hypercholesterolaemia 11.18 11.11 272 844311 15101 63639048
Enuresis 11.17 11.11 12 844571 2778 63651371
Blood testosterone decreased 11.17 11.11 7 844576 2118 63652031
Arrhythmia supraventricular 11.16 11.11 5 844578 1828 63652321
Therapeutic response delayed 11.16 11.11 31 844552 851 63653298
Portal tract inflammation 11.16 11.11 11 844572 120 63654029
Yersinia infection 11.14 11.11 6 844577 22 63654127
Lung neoplasm 11.13 11.11 129 844454 6176 63647973
Bronchial secretion retention 11.12 11.11 10 844573 2517 63651632
Disseminated coccidioidomycosis 11.12 11.11 8 844575 54 63654095
Symptom recurrence 11.12 11.11 32 844551 897 63653252
Orthosis user 11.12 11.11 8 844575 54 63654095

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L01BA01 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
ANTIMETABOLITES
Folic acid analogues
ATC L04AX03 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
IMMUNOSUPPRESSANTS
IMMUNOSUPPRESSANTS
Other immunosuppressants
FDA MoA N0000000111 Folic Acid Metabolism Inhibitors
FDA EPC N0000175584 Folate Analog Metabolic Inhibitor
MeSH PA D000019 Abortifacient Agents
MeSH PA D000020 Abortifacient Agents, Nonsteroidal
MeSH PA D000963 Antimetabolites
MeSH PA D000964 Antimetabolites, Antineoplastic
MeSH PA D000970 Antineoplastic Agents
MeSH PA D018501 Antirheumatic Agents
MeSH PA D003879 Dermatologic Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D005493 Folic Acid Antagonists
MeSH PA D007155 Immunologic Factors
MeSH PA D007166 Immunosuppressive Agents
MeSH PA D009676 Noxae
MeSH PA D019384 Nucleic Acid Synthesis Inhibitors
MeSH PA D012102 Reproductive Control Agents
CHEBI has role CHEBI:35221 antimetabolite
CHEBI has role CHEBI:35610 antineoplastic agents
CHEBI has role CHEBI:35705 immunosuppressive agents
CHEBI has role CHEBI:35842 anti-rheumatic drugs
CHEBI has role CHEBI:50177 dermatologic agent
CHEBI has role CHEBI:50683 dihydrofolic acid reductase inhibitors
CHEBI has role CHEBI:50691 abortifacient drug
CHEBI has role CHEBI:59517 DNA synthesis inhibitors

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Psoriasis indication 9014002 DOID:8893
Rheumatoid arthritis indication 69896004 DOID:7148
Acute lymphoid leukemia indication 91857003 DOID:9952
Non-Hodgkin's lymphoma indication 118601006
Burkitt's lymphoma indication 118617000
Mycosis fungoides indication 118618005
Psoriatic arthritis indication 156370009 DOID:9008
Plaque psoriasis indication 200965009
Pustular psoriasis indication 200973000
Erythrodermic psoriasis indication 200977004
Malignant tumor of head and/or neck indication 255056009
Osteosarcoma of bone indication 307576001 DOID:3376
Malignant tumor of lung indication 363358000
Juvenile rheumatoid arthritis indication 410795001
Carcinoma of female breast indication 447782002
Gestational trophoblastic neoplasia indication 609519004 DOID:3590
Meningeal Leukemia indication
Polymyositis off-label use 31384009
Vasculitis off-label use 31996006 DOID:865
Psoriasis with arthropathy off-label use 33339001
Systemic lupus erythematosus off-label use 55464009 DOID:9074
Acute myeloid leukemia, disease off-label use 91861009
Acute promyelocytic leukemia, FAB M3 off-label use 110004001
Wegener's granulomatosis off-label use 195353004 DOID:12132
Malignant tumor of urinary bladder off-label use 399326009 DOID:11054
Systemic Dermatomyositis off-label use
Alcoholism contraindication 7200002
Peptic ulcer contraindication 13200003 DOID:750
Dehydration contraindication 34095006
Fibrosis of lung contraindication 51615001 DOID:3770
Acute nephropathy contraindication 58574008
Hepatic failure contraindication 59927004
Stomatitis contraindication 61170000 DOID:9637
Interstitial pneumonia contraindication 64667001
Ulcerative colitis contraindication 64766004 DOID:8577
Leukopenia contraindication 84828003 DOID:615
Kidney disease contraindication 90708001 DOID:557
Disease of liver contraindication 235856003 DOID:409
Anemia contraindication 271737000 DOID:2355
Pregnancy, function contraindication 289908002
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Bone marrow depression contraindication 307762000
Ascites contraindication 389026000
Gastric ulcer contraindication 397825006 DOID:10808
Breastfeeding (mother) contraindication 413712001
Disorder of immune function contraindication 414029004
Methotrexate Toxicity contraindication
Pleural Effusions contraindication




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.61 acidic
pKa2 5.15 acidic
pKa3 12.92 acidic
pKa4 5.73 Basic
pKa5 4.51 Basic
pKa6 1.39 Basic
pKa7 0.75 Basic
pKa8 0.08 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
10MG/0.20ML (10MG/0.20ML) RASUVO MEDEXUS N205776 July 10, 2014 RX SOLUTION SUBCUTANEOUS 8664231 June 1, 2029 SUBCUTANEOUS INJECTION OF METHOTREXATE
12.5MG/0.25ML (12.5MG/0.25ML) RASUVO MEDEXUS N205776 July 10, 2014 RX SOLUTION SUBCUTANEOUS 8664231 June 1, 2029 SUBCUTANEOUS INJECTION OF METHOTREXATE
15MG/0.30ML (15MG/0.30ML) RASUVO MEDEXUS N205776 July 10, 2014 RX SOLUTION SUBCUTANEOUS 8664231 June 1, 2029 SUBCUTANEOUS INJECTION OF METHOTREXATE
17.5MG/0.35ML (17.5MG/0.35ML) RASUVO MEDEXUS N205776 July 10, 2014 RX SOLUTION SUBCUTANEOUS 8664231 June 1, 2029 SUBCUTANEOUS INJECTION OF METHOTREXATE
20MG/0.4ML (20MG/0.4ML) RASUVO MEDEXUS N205776 July 10, 2014 RX SOLUTION SUBCUTANEOUS 8664231 June 1, 2029 SUBCUTANEOUS INJECTION OF METHOTREXATE
22.5MG/0.45ML (22.5MG/0.45ML) RASUVO MEDEXUS N205776 July 10, 2014 RX SOLUTION SUBCUTANEOUS 8664231 June 1, 2029 SUBCUTANEOUS INJECTION OF METHOTREXATE
25MG/0.5ML (25MG/0.5ML) RASUVO MEDEXUS N205776 July 10, 2014 RX SOLUTION SUBCUTANEOUS 8664231 June 1, 2029 SUBCUTANEOUS INJECTION OF METHOTREXATE
27.5MG/0.55ML (27.5MG/0.55ML) RASUVO MEDEXUS N205776 July 10, 2014 DISCN SOLUTION SUBCUTANEOUS 8664231 June 1, 2029 SUBCUTANEOUS INJECTION OF METHOTREXATE
30MG/0.6ML (30MG/0.6ML) RASUVO MEDEXUS N205776 July 10, 2014 RX SOLUTION SUBCUTANEOUS 8664231 June 1, 2029 SUBCUTANEOUS INJECTION OF METHOTREXATE
7.5MG/0.15ML (7.5MG/0.15ML) RASUVO MEDEXUS N205776 July 10, 2014 RX SOLUTION SUBCUTANEOUS 8664231 June 1, 2029 SUBCUTANEOUS INJECTION OF METHOTREXATE
10MG/0.4ML (10MG/0.4ML) OTREXUP OTTER PHARMS N204824 Oct. 11, 2013 RX SOLUTION SUBCUTANEOUS 8480631 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
10MG/0.4ML (10MG/0.4ML) OTREXUP OTTER PHARMS N204824 Oct. 11, 2013 RX SOLUTION SUBCUTANEOUS 8579865 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
10MG/0.4ML (10MG/0.4ML) OTREXUP OTTER PHARMS N204824 Oct. 11, 2013 RX SOLUTION SUBCUTANEOUS 8945063 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
10MG/0.4ML (10MG/0.4ML) OTREXUP OTTER PHARMS N204824 Oct. 11, 2013 RX SOLUTION SUBCUTANEOUS 9421333 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
12.5MG/0.4ML (12.5MG/0.4ML) OTREXUP OTTER PHARMS N204824 March 24, 2016 RX SOLUTION SUBCUTANEOUS 8480631 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
12.5MG/0.4ML (12.5MG/0.4ML) OTREXUP OTTER PHARMS N204824 March 24, 2016 RX SOLUTION SUBCUTANEOUS 8579865 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
12.5MG/0.4ML (12.5MG/0.4ML) OTREXUP OTTER PHARMS N204824 March 24, 2016 RX SOLUTION SUBCUTANEOUS 8945063 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
12.5MG/0.4ML (12.5MG/0.4ML) OTREXUP OTTER PHARMS N204824 March 24, 2016 RX SOLUTION SUBCUTANEOUS 9421333 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
15MG/0.4ML (15MG/0.4ML) OTREXUP OTTER PHARMS N204824 Oct. 11, 2013 RX SOLUTION SUBCUTANEOUS 8480631 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
15MG/0.4ML (15MG/0.4ML) OTREXUP OTTER PHARMS N204824 Oct. 11, 2013 RX SOLUTION SUBCUTANEOUS 8579865 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
15MG/0.4ML (15MG/0.4ML) OTREXUP OTTER PHARMS N204824 Oct. 11, 2013 RX SOLUTION SUBCUTANEOUS 8945063 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
15MG/0.4ML (15MG/0.4ML) OTREXUP OTTER PHARMS N204824 Oct. 11, 2013 RX SOLUTION SUBCUTANEOUS 9421333 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
17.5MG/0.4ML (17.5MG/0.4ML) OTREXUP OTTER PHARMS N204824 March 24, 2016 RX SOLUTION SUBCUTANEOUS 8480631 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
17.5MG/0.4ML (17.5MG/0.4ML) OTREXUP OTTER PHARMS N204824 March 24, 2016 RX SOLUTION SUBCUTANEOUS 8579865 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
17.5MG/0.4ML (17.5MG/0.4ML) OTREXUP OTTER PHARMS N204824 March 24, 2016 RX SOLUTION SUBCUTANEOUS 8945063 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
17.5MG/0.4ML (17.5MG/0.4ML) OTREXUP OTTER PHARMS N204824 March 24, 2016 RX SOLUTION SUBCUTANEOUS 9421333 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
20MG/0.4ML (20MG/0.4ML) OTREXUP OTTER PHARMS N204824 Oct. 11, 2013 RX SOLUTION SUBCUTANEOUS 8480631 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
20MG/0.4ML (20MG/0.4ML) OTREXUP OTTER PHARMS N204824 Oct. 11, 2013 RX SOLUTION SUBCUTANEOUS 8579865 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
20MG/0.4ML (20MG/0.4ML) OTREXUP OTTER PHARMS N204824 Oct. 11, 2013 RX SOLUTION SUBCUTANEOUS 8945063 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
20MG/0.4ML (20MG/0.4ML) OTREXUP OTTER PHARMS N204824 Oct. 11, 2013 RX SOLUTION SUBCUTANEOUS 9421333 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
22.5MG/0.4ML (22.5MG/0.4ML) OTREXUP OTTER PHARMS N204824 March 24, 2016 RX SOLUTION SUBCUTANEOUS 8480631 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
22.5MG/0.4ML (22.5MG/0.4ML) OTREXUP OTTER PHARMS N204824 March 24, 2016 RX SOLUTION SUBCUTANEOUS 8579865 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
22.5MG/0.4ML (22.5MG/0.4ML) OTREXUP OTTER PHARMS N204824 March 24, 2016 RX SOLUTION SUBCUTANEOUS 8945063 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
22.5MG/0.4ML (22.5MG/0.4ML) OTREXUP OTTER PHARMS N204824 March 24, 2016 RX SOLUTION SUBCUTANEOUS 9421333 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
25MG/0.4ML (25MG/0.4ML) OTREXUP OTTER PHARMS N204824 Oct. 11, 2013 RX SOLUTION SUBCUTANEOUS 8480631 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
25MG/0.4ML (25MG/0.4ML) OTREXUP OTTER PHARMS N204824 Oct. 11, 2013 RX SOLUTION SUBCUTANEOUS 8579865 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
25MG/0.4ML (25MG/0.4ML) OTREXUP OTTER PHARMS N204824 Oct. 11, 2013 RX SOLUTION SUBCUTANEOUS 8945063 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
25MG/0.4ML (25MG/0.4ML) OTREXUP OTTER PHARMS N204824 Oct. 11, 2013 RX SOLUTION SUBCUTANEOUS 9421333 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
7.5MG/0.4ML (7.5MG/0.4ML) OTREXUP OTTER PHARMS N204824 Nov. 7, 2014 DISCN SOLUTION SUBCUTANEOUS 8480631 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
7.5MG/0.4ML (7.5MG/0.4ML) OTREXUP OTTER PHARMS N204824 Nov. 7, 2014 DISCN SOLUTION SUBCUTANEOUS 8579865 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
7.5MG/0.4ML (7.5MG/0.4ML) OTREXUP OTTER PHARMS N204824 Nov. 7, 2014 DISCN SOLUTION SUBCUTANEOUS 8945063 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
7.5MG/0.4ML (7.5MG/0.4ML) OTREXUP OTTER PHARMS N204824 Nov. 7, 2014 DISCN SOLUTION SUBCUTANEOUS 9421333 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
EQ 2.5MG BASE/ML XATMEP AZURITY N208400 April 25, 2017 RX SOLUTION ORAL 10231927 Jan. 2, 2033 A METHOD FOR TREATING ACUTE LYMPHOBLASTIC LEUKEMIA
EQ 2.5MG BASE/ML XATMEP AZURITY N208400 April 25, 2017 RX SOLUTION ORAL 10231927 Jan. 2, 2033 TREATMENT OF JUVENILE RHEUMATOID ARTHRITIS
EQ 2.5MG BASE/ML XATMEP AZURITY N208400 April 25, 2017 RX SOLUTION ORAL 11116724 Jan. 2, 2033 A METHOD FOR TREATING ACUTE LYMPHOBLASTIC LEUKEMIA
EQ 2.5MG BASE/ML XATMEP AZURITY N208400 April 25, 2017 RX SOLUTION ORAL 11116724 Jan. 2, 2033 TREATMENT OF JUVENILE RHEUMATOID ARTHRITIS

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
EQ 2.5MG BASE/ML XATMEP AZURITY N208400 April 25, 2017 RX SOLUTION ORAL April 25, 2024 TREATMENT OF OLIGOARTICULAR JUVENILE IDIOPATHIC ARTHRITIS (PERSISTENT OLIGOARTHRITIS, PSORIATIC JUVENILE IDIOPATHIC ARTHRITIS, ENTHESITIS-RELATED ARTHRITIS, OR UNDIFFERENTIATED ARTHRITIS) & POLYARTICULAR JUVENILE IDIOPATHIC ARTHRITIS IN CHILDREN 0-16 YRS
EQ 2.5MG BASE/ML XATMEP AZURITY N208400 April 25, 2017 RX SOLUTION ORAL April 25, 2024 TREATMENT OF PEDIATRIC PATIENTS WITH ACUTE LYMPHOBLASTIC LEUKEMIA AS A COMPONENT OF A COMBINATION CHEOMOTHERAPY MAINTENANCE REGIMEN

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Dihydrofolate reductase Enzyme INHIBITOR Ki 8.92 IUPHAR DRUG LABEL
Canalicular multispecific organic anion transporter 1 Transporter WOMBAT-PK
Multidrug resistance-associated protein 1 Transporter WOMBAT-PK
ATP-binding cassette sub-family G member 2 Transporter WOMBAT-PK
Thymidylate synthase Enzyme Ki 6.22 CHEMBL
Multidrug resistance-associated protein 5 Transporter WOMBAT-PK
Folylpolyglutamate synthase, mitochondrial Enzyme IC50 5.49 CHEMBL
Multidrug resistance-associated protein 4 Transporter WOMBAT-PK
Folate receptor beta Membrane receptor IC50 6.97 CHEMBL
Proton-coupled folate transporter Transporter IC50 6.92 CHEMBL
Multidrug resistance protein 1 Transporter WOMBAT-PK
Folate transporter 1 Transporter Ki 5.46 CHEMBL
Folate receptor alpha Membrane receptor IC50 6.94 CHEMBL
High mobility group protein B1 Nuclear other Kd 7.62 CHEMBL
Bifunctional purine biosynthesis protein PURH Enzyme Ki 6.06 CHEMBL
Bifunctional dihydrofolate reductase-thymidylate synthase Enzyme IC50 8.85 CHEMBL
Dihydrofolate reductase Enzyme IC50 9 CHEMBL
Bifunctional dihydrofolate reductase-thymidylate synthase Enzyme IC50 7.08 CHEMBL
Dihydrofolate reductase Enzyme Ki 5.41 CHEMBL
Dihydrofolate reductase Enzyme Ki 10.14 CHEMBL
Dihydrofolate reductase Enzyme Ki 10.68 CHEMBL
Dihydrofolate reductase Enzyme IC50 8.89 CHEMBL
Bifunctional dihydrofolate reductase-thymidylate synthase Enzyme Ki 9.89 CHEMBL
Dihydrofolate reductase Enzyme IC50 7.72 CHEMBL
Thymidylate synthase Enzyme IC50 4.40 CHEMBL
Dihydrofolate reductase Enzyme Ki 10.68 CHEMBL
Thymidylate synthase Enzyme IC50 5.74 CHEMBL
Pteridine reductase 1 Enzyme Ki 7.41 CHEMBL
Dihydrofolate reductase Enzyme Ki 9 CHEMBL
Dihydrofolate reductase Enzyme IC50 8.08 CHEMBL
Dihydrofolate reductase Enzyme IC50 7.91 CHEMBL
Dihydrofolate reductase Enzyme IC50 8.77 CHEMBL
Dihydrofolate reductase Enzyme IC50 8.85 CHEMBL
Thymidylate synthase Enzyme Ki 4.35 CHEMBL

External reference:

IDSource
4019828 VUID
N0000147916 NUI
D00142 KEGG_DRUG
7413-34-5 SECONDARY_CAS_RN
4017903 VANDF
4019828 VANDF
C0025677 UMLSCUI
CHEBI:44185 CHEBI
MTX PDB_CHEM_ID
CHEMBL34259 ChEMBL_ID
CHEMBL426 ChEMBL_ID
CHEMBL3244648 ChEMBL_ID
D008727 MESH_DESCRIPTOR_UI
DB00563 DRUGBANK_ID
4815 IUPHAR_LIGAND_ID
926 INN_ID
YL5FZ2Y5U1 UNII
126941 PUBCHEM_CID
287734 RXNORM
12261 MMSL
30391 MMSL
5077 MMSL
6313 MMSL
73119 MMSL
d00060 MMSL
002644 NDDF
002645 NDDF
387381009 SNOMEDCT_US
412247000 SNOMEDCT_US
68887009 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Methotrexate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0054-4550 TABLET 2.50 mg ORAL ANDA 28 sections
Methotrexate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0054-8550 TABLET 2.50 mg ORAL ANDA 28 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 0143-9367 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 1 g INTRA-ARTERIAL ANDA 23 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 0143-9516 SOLUTION 25 mg INTRA-ARTERIAL ANDA 33 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 0143-9517 SOLUTION 25 mg INTRA-ARTERIAL ANDA 33 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 0143-9518 SOLUTION 25 mg INTRA-ARTERIAL ANDA 33 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 0143-9519 SOLUTION 25 mg INTRA-ARTERIAL ANDA 33 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 0143-9830 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 1 g INTRA-ARTERIAL ANDA 23 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 0378-0014 TABLET 2.50 mg ORAL ANDA 28 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 0378-0014 TABLET 2.50 mg ORAL ANDA 28 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 0555-0572 TABLET 2.50 mg ORAL ANDA 28 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 0703-3671 INJECTION, SOLUTION 25 mg INTRA-ARTERIAL ANDA 28 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 0703-3675 INJECTION, SOLUTION 25 mg INTRA-ARTERIAL ANDA 28 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 0703-3678 INJECTION, SOLUTION 25 mg INTRA-ARTERIAL ANDA 28 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 0703-3678 INJECTION, SOLUTION 25 mg INTRA-ARTERIAL ANDA 28 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 0904-7141 TABLET 2.50 mg ORAL ANDA 26 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 16729-277 INJECTION 25 mg INTRA-ARTERIAL ANDA 29 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 16729-486 TABLET 2.50 mg ORAL ANDA 30 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 42291-505 TABLET 2.50 mg ORAL ANDA 28 sections
Methotrexate Human Prescription Drug Label 1 47335-235 TABLET 2.50 mg ORAL ANDA 30 sections
METHOTREXATE HUMAN PRESCRIPTION DRUG LABEL 1 47781-482 TABLET 2.50 mg ORAL ANDA 27 sections
Methotrexate Human Prescription Drug Label 1 50090-3418 TABLET 2.50 mg ORAL ANDA 30 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 50090-5457 TABLET 2.50 mg ORAL ANDA 28 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 50268-527 TABLET 2.50 mg ORAL ANDA 28 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 51079-570 TABLET 2.50 mg ORAL ANDA 29 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 51079-670 TABLET 2.50 mg ORAL ANDA 29 sections
Trexall HUMAN PRESCRIPTION DRUG LABEL 1 51285-366 TABLET, FILM COATED 5 mg ORAL ANDA 28 sections
Trexall HUMAN PRESCRIPTION DRUG LABEL 1 51285-367 TABLET, FILM COATED 7.50 mg ORAL ANDA 28 sections
Trexall HUMAN PRESCRIPTION DRUG LABEL 1 51285-368 TABLET, FILM COATED 10 mg ORAL ANDA 28 sections
Trexall HUMAN PRESCRIPTION DRUG LABEL 1 51285-369 TABLET, FILM COATED 15 mg ORAL ANDA 28 sections