methotrexate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
folic acid analogues 1751 59-05-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • methotrexate
  • methotrexate sodium
  • amethopterin
  • amethopterine
  • L-Amethopterin
  • ledertrexate
  • metatrexan
  • methoxtrexate
  • methylaminopterin
An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.
  • Molecular weight: 454.45
  • Formula: C20H22N8O5
  • CLOGP: -0.03
  • LIPINSKI: 1
  • HAC: 13
  • HDO: 5
  • TPSA: 210.54
  • ALOGS: -3.42
  • ROTB: 9
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
2.50 mg O
2.50 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.17 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 81 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 1.10 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 77 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.43 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 2.10 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.37 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 3.90 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,ERBB2,FLT3,GRK2,GRK3,ITK,JAK1,JAK2,MAP2K6,MAP3K14,MAP3K21,MAP3K7,MAPK10,MAPK7,MTOR,NTRK2,PDK1,PDK2,PIK3CA,PIK3CB,PIK3CD,PIK3CG,PIM2,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TTK 42
kinase-selectivity-class AXL,EIF2AK3,GRK2,GRK3,MAPK7 5
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 0.530 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pld-class Phospholipidosis risk class (1 = positive, 0 = negative) 0 High 1
rat-kpuu-brain Rat brain Kpuu 0.005 % High 1

Approvals:

DateAgencyCompanyOrphan
March 26, 2019 PMDA PFIZER JAPAN INC.
Dec. 7, 1953 FDA DAVA PHARMS INC
Aug. 18, 2016 EMA Nordic Group B.V.

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 13153.45 11.00 47374 1291359 1336924 87952790
Drug intolerance 4007.58 11.00 15098 1323635 432493 88857221
Treatment failure 3151.24 11.00 10762 1327971 293166 88996548
Joint swelling 2386.09 11.00 14116 1324617 489184 88800530
Arthralgia 2322.50 11.00 19502 1319231 759020 88530694
Death 2064.94 11.00 2220 1336513 454331 88835383
Completed suicide 1902.75 11.00 51 1338682 145007 89144707
Drug hypersensitivity 1749.99 11.00 12279 1326454 451330 88838384
Lymphoproliferative disorder 1716.04 11.00 959 1337774 3303 89286411
Therapeutic product effect incomplete 1697.68 11.00 6502 1332231 187394 89102320
Therapeutic product effect decreased 1692.15 11.00 8345 1330388 269226 89020488
Contraindicated product administered 1639.00 11.00 9170 1329563 310969 88978745
Constipation 1470.99 11.00 1190 1337543 279205 89010509
Synovitis 1380.60 11.00 8964 1329769 320788 88968926
Rheumatoid arthritis 1325.98 11.00 9534 1329199 353080 88936634
Musculoskeletal stiffness 1204.44 11.00 8001 1330732 288531 89001183
Hypotension 1116.84 11.00 1932 1336801 323465 88966249
Intentional overdose 1003.07 11.00 108 1338625 93726 89195988
Dyspnoea 969.15 11.00 8344 1330389 872611 88417103
Pancytopenia 898.09 11.00 3840 1334893 116423 89173291
Arthropathy 895.53 11.00 8800 1329933 357442 88932272
Mouth ulceration 889.47 11.00 1881 1336852 38093 89251621
Alopecia 864.65 11.00 11134 1327599 483937 88805777
Hyponatraemia 856.94 11.00 451 1338282 133087 89156627
Somnolence 850.25 11.00 1104 1337629 207980 89081734
Dehydration 835.54 11.00 984 1337749 193463 89096251
Acute kidney injury 814.20 11.00 2247 1336486 318140 88971574
Drug abuse 789.47 11.00 133 1338600 82214 89207500
Anaemia 745.56 11.00 2689 1336044 350113 88939601
Electrocardiogram QT prolonged 733.60 11.00 100 1338633 72356 89217358
Pain 723.83 11.00 19538 1319195 976803 88312911
Liver function test increased 705.57 11.00 2801 1335932 82054 89207660
Bradycardia 658.07 11.00 209 1338524 83638 89206076
Arthritis 654.71 11.00 4475 1334258 162840 89126874
Tremor 645.32 11.00 787 1337946 152386 89137328
Dizziness 630.23 11.00 5618 1333115 583666 88706048
Condition aggravated 613.59 11.00 12268 1326465 583277 88706437
Hyperkalaemia 600.91 11.00 115 1338618 64849 89224865
Cardiac arrest 597.96 11.00 408 1338325 104527 89185187
Multiple sclerosis relapse 597.06 11.00 46 1338687 52259 89237455
Psoriasis 591.27 11.00 3974 1334759 143780 89145934
Suicide attempt 581.04 11.00 194 1338539 75205 89214509
Depressed level of consciousness 573.74 11.00 180 1338553 72604 89217110
Sedation 571.31 11.00 35 1338698 48136 89241578
Swelling 569.42 11.00 9021 1329712 410037 88879677
Diffuse large B-cell lymphoma 556.82 11.00 663 1338070 7982 89281732
Device expulsion 553.08 11.00 10 1338723 40876 89248838
Abdominal discomfort 551.27 11.00 10008 1328725 467320 88822394
Red blood cell sedimentation rate abnormal 543.14 11.00 1143 1337590 23061 89266653
Malignant neoplasm progression 536.03 11.00 473 1338260 106397 89183317
Hallucination 532.80 11.00 156 1338577 65803 89223911
Overdose 529.98 11.00 948 1337785 156761 89132953
Infection 520.50 11.00 7870 1330863 354224 88935490
Product dose omission issue 520.46 11.00 2375 1336358 289312 89000402
Drug interaction 510.08 11.00 2223 1336510 274230 89015484
Diarrhoea 506.67 11.00 10313 1328420 928877 88360837
Hypokalaemia 493.10 11.00 732 1338001 130384 89159330
Agitation 492.52 11.00 187 1338546 66911 89222803
Seizure 485.04 11.00 949 1337784 151680 89138034
Cardio-respiratory arrest 475.22 11.00 169 1338564 62971 89226743
Pneumocystis jirovecii pneumonia 470.26 11.00 1008 1337725 20608 89269106
Psoriatic arthropathy 467.74 11.00 5296 1333437 223039 89066675
Balance disorder 462.85 11.00 450 1338283 96630 89193084
Lactic acidosis 461.10 11.00 92 1338641 50371 89239343
Hypoglycaemia 456.79 11.00 230 1338503 69618 89220096
Hyperhidrosis 453.79 11.00 824 1337909 135481 89154233
Rheumatoid nodule 446.33 11.00 947 1337786 19219 89270495
Epstein Barr virus positive mucocutaneous ulcer 445.98 11.00 204 1338529 392 89289322
C-reactive protein increased 444.71 11.00 4363 1334370 177026 89112688
Anxiety 443.35 11.00 2718 1336015 307054 88982660
Hepatic enzyme increased 440.08 11.00 7631 1331102 353105 88936609
Systemic lupus erythematosus 439.87 11.00 7651 1331082 354245 88935469
Mucosal inflammation 433.04 11.00 1844 1336889 55781 89233933
Tuberculosis 432.98 11.00 713 1338020 11836 89277878
Red blood cell sedimentation rate increased 426.20 11.00 2373 1336360 80222 89209492
Rhabdomyolysis 423.68 11.00 116 1338617 51140 89238574
Serotonin syndrome 422.25 11.00 37 1338696 37850 89251864
Gastrointestinal disorder 415.05 11.00 5696 1333037 250991 89038723
Exposure during pregnancy 412.30 11.00 1963 1336770 236447 89053267
Cognitive disorder 410.13 11.00 259 1338474 69148 89220566
Decreased appetite 406.63 11.00 3579 1335154 372961 88916753
Fall 400.54 11.00 4872 1333861 476938 88812776
Syncope 400.12 11.00 850 1337883 131813 89157901
Asthenia 395.71 11.00 5528 1333205 528223 88761491
Orthostatic hypotension 382.71 11.00 76 1338657 41751 89247963
Coma 380.73 11.00 308 1338425 72324 89217390
Loss of personal independence in daily activities 372.63 11.00 3352 1335381 132753 89156961
Peripheral swelling 369.59 11.00 8340 1330393 404766 88884948
International normalised ratio increased 369.38 11.00 119 1338614 47197 89242517
Epstein-Barr virus associated lymphoproliferative disorder 364.81 11.00 308 1338425 2359 89287355
Uveitis 359.14 11.00 753 1337980 15150 89274564
Hospitalisation 356.84 11.00 857 1337876 127243 89162471
Oedema peripheral 356.54 11.00 2287 1336446 255628 89034086
Cardiac failure congestive 352.88 11.00 570 1338163 98124 89191590
Acute graft versus host disease 348.30 11.00 417 1338316 5051 89284663
Toxicity to various agents 347.58 11.00 2655 1336078 285191 89004523
Asthma 345.71 11.00 2126 1336607 240034 89049680
Tachycardia 343.16 11.00 1186 1337547 156487 89133227
Intentional self-injury 342.85 11.00 23 1338710 29311 89260403
Osteoarthritis 340.15 11.00 4401 1334332 191329 89098385
Platelet count decreased 338.36 11.00 973 1337760 135996 89153718
Blood glucose increased 337.81 11.00 553 1338180 94693 89195021
Fluid retention 336.85 11.00 486 1338247 87605 89202109
Neuropathy peripheral 333.99 11.00 979 1337754 135991 89153723
Inflammation 325.34 11.00 4051 1334682 174541 89115173
Hypoxia 324.26 11.00 354 1338379 72045 89217669
Pain in extremity 323.48 11.00 8829 1329904 441700 88848014
Interstitial lung disease 322.44 11.00 2083 1336650 74322 89215392
Vision blurred 322.39 11.00 719 1338014 109574 89180140
Drug reaction with eosinophilia and systemic symptoms 319.12 11.00 116 1338617 42642 89247072
Metabolic acidosis 317.78 11.00 216 1338517 55460 89234254
Nodule 315.98 11.00 990 1337743 25696 89264018
Pemphigus 315.46 11.00 6672 1332061 320192 88969522
Chest discomfort 309.79 11.00 1028 1337705 137337 89152377
Drug withdrawal syndrome 309.63 11.00 32 1338701 28691 89261023
Joint stiffness 305.42 11.00 2088 1336645 75954 89213760
Sopor 304.46 11.00 14 1338719 24630 89265084
Unresponsive to stimuli 302.71 11.00 93 1338640 38028 89251686
Dry skin 302.52 11.00 522 1338211 87551 89202163
Leukoencephalopathy 299.58 11.00 365 1338368 4508 89285206
Hand deformity 296.92 11.00 6083 1332650 290279 88999435
Foetal exposure during pregnancy 294.03 11.00 133 1338600 42842 89246872
Herpes zoster 290.51 11.00 2391 1336342 92253 89197461
C-reactive protein abnormal 289.56 11.00 3018 1335715 124411 89165303
Ankylosing spondylitis 288.64 11.00 615 1338118 12518 89277196
Chronic graft versus host disease 284.16 11.00 328 1338405 3811 89285903
Premature delivery 282.85 11.00 109 1338624 38653 89251061
Haemoglobin decreased 276.10 11.00 1340 1337393 160616 89129098
Flushing 268.45 11.00 565 1338168 87926 89201788
Chest pain 268.05 11.00 3225 1335508 316420 88973294
Musculoskeletal disorder 266.46 11.00 817 1337916 20952 89268762
Nasopharyngitis 264.09 11.00 7877 1330856 399227 88890487
Suicidal ideation 260.78 11.00 430 1338303 73425 89216289
Vomiting 258.45 11.00 9288 1329445 779005 88510709
Gastrointestinal haemorrhage 257.52 11.00 596 1338137 89652 89200062
Basal cell carcinoma 256.69 11.00 1076 1337657 32313 89257401
White blood cell count decreased 255.48 11.00 1435 1337298 165674 89124040
Hypomagnesaemia 251.63 11.00 105 1338628 35483 89254231
Pulmonary tuberculosis 249.63 11.00 332 1338401 4502 89285212
Contraindication to medical treatment 248.48 11.00 162 1338571 787 89288927
Muscle spasms 245.98 11.00 2454 1336279 249429 89040285
Respiratory arrest 245.85 11.00 92 1338641 33219 89256495
Angioedema 245.01 11.00 361 1338372 64515 89225199
Blood calcium decreased 242.61 11.00 72 1338661 30110 89259604
Lymphoma 241.47 11.00 585 1338148 13006 89276708
Epstein-Barr virus infection 239.69 11.00 495 1338238 9849 89279865
Dysgeusia 236.47 11.00 256 1338477 52304 89237410
Neutrophil count decreased 235.72 11.00 435 1338298 71097 89218617
Stomatitis 235.48 11.00 5514 1333219 269184 89020530
Histoplasmosis disseminated 232.05 11.00 224 1338509 2081 89287633
Sedation complication 229.77 11.00 4 1338729 16940 89272774
Disturbance in attention 229.62 11.00 214 1338519 46895 89242819
Plasma cell myeloma 229.54 11.00 161 1338572 40667 89249047
Lower respiratory tract infection 228.71 11.00 5076 1333657 245583 89044131
Restlessness 228.52 11.00 121 1338612 35599 89254115
Myalgia 228.28 11.00 1580 1337153 173545 89116169
Injection site reaction 227.53 11.00 2219 1336514 89861 89199853
Palpitations 227.43 11.00 1141 1337592 135587 89154127
Poisoning deliberate 227.36 11.00 3 1338730 16483 89273231
Tenosynovitis 224.39 11.00 594 1338139 13973 89275741
Macular degeneration 223.88 11.00 142 1338591 37828 89251886
Cardiac failure 223.39 11.00 846 1337887 108650 89181064
Dyskinesia 223.27 11.00 131 1338602 36403 89253311
Joint effusion 221.31 11.00 718 1338015 18992 89270722
Tuberculin test positive 219.31 11.00 273 1338460 3452 89286262
Blood potassium decreased 218.59 11.00 229 1338504 47498 89242216
Glossodynia 213.41 11.00 6244 1332489 315535 88974179
Product use issue 209.35 11.00 6367 1332366 323552 88966162
Therapeutic response decreased 208.96 11.00 2136 1336597 87593 89202121
Arthritis bacterial 208.66 11.00 386 1338347 7059 89282655
Withdrawal syndrome 208.01 11.00 40 1338693 22484 89267230
Paraesthesia oral 207.36 11.00 104 1338629 31555 89258159
Foot deformity 207.30 11.00 1551 1337182 58100 89231614
Blood pressure decreased 206.20 11.00 504 1338229 74391 89215323
Full blood count decreased 206.07 11.00 90 1338643 29599 89260115
Dyspnoea exertional 204.95 11.00 479 1338254 71809 89217905
Knee arthroplasty 204.75 11.00 2003 1336730 81179 89208535
Breast cancer 203.61 11.00 1427 1337306 52334 89237380
Intentional product misuse 203.10 11.00 662 1338071 88942 89200772
Rheumatoid factor positive 201.03 11.00 3609 1335124 168041 89121673
Lethargy 201.00 11.00 392 1338341 62747 89226967
Pneumonia aspiration 199.51 11.00 186 1338547 40754 89248960
Device dislocation 199.41 11.00 108 1338625 31374 89258340
Angiocentric lymphoma 198.44 11.00 127 1338606 594 89289120
Hyperglycaemia 197.02 11.00 279 1338454 50691 89239023
Skin ulcer 196.04 11.00 1340 1337393 48735 89240979
Palmar-plantar erythrodysaesthesia syndrome 196.01 11.00 84 1338649 27939 89261775
Juvenile idiopathic arthritis 194.49 11.00 266 1338467 3711 89286003
Loss of consciousness 194.43 11.00 1242 1337491 138996 89150718
Mental status changes 194.01 11.00 224 1338509 44455 89245259
Creatinine renal clearance decreased 193.87 11.00 25 1338708 18874 89270840
Deformity 193.32 11.00 502 1338231 11668 89278046
Neuroleptic malignant syndrome 191.78 11.00 7 1338726 15089 89274625
Ventricular tachycardia 191.34 11.00 63 1338670 24645 89265069
Pulmonary embolism 190.50 11.00 1141 1337592 129679 89160035
Disorientation 189.58 11.00 223 1338510 43891 89245823
Blood iron abnormal 184.82 11.00 261 1338472 3759 89285955
Hypervolaemia 181.75 11.00 131 1338602 32626 89257088
B-cell lymphoma 181.54 11.00 246 1338487 3400 89286314
Disease progression 181.22 11.00 1461 1337272 155154 89134560
Diabetic ketoacidosis 179.14 11.00 68 1338665 24339 89265375
Drug clearance decreased 179.04 11.00 178 1338555 1720 89287994
Atrial fibrillation 177.80 11.00 1198 1337535 132413 89157301
Wheezing 177.69 11.00 2461 1336272 235619 89054095
Premature baby 177.28 11.00 74 1338659 25003 89264711
Renal failure 176.16 11.00 1171 1337562 129836 89159878
Acute graft versus host disease in skin 176.04 11.00 279 1338454 4477 89285237
Muscle twitching 175.03 11.00 69 1338664 24133 89265581
Cerebrovascular accident 174.88 11.00 1087 1337646 122446 89167268
Fear of injection 172.63 11.00 386 1338347 8129 89281585
Respiratory depression 171.43 11.00 16 1338717 15559 89274155
Abdominal pain 171.10 11.00 4492 1334241 391229 88898485
Musculoskeletal pain 170.31 11.00 3512 1335221 167739 89121975
Sinusitis 169.94 11.00 6433 1332300 336655 88953059
Caesarean section 169.43 11.00 34 1338699 18543 89271171
Obstructive airways disorder 169.40 11.00 85 1338648 25784 89263930
Pulmonary hypertension 169.14 11.00 228 1338505 42295 89247419
Hallucination, visual 166.73 11.00 66 1338667 23026 89266688
Disseminated tuberculosis 166.41 11.00 224 1338509 3075 89286639
Blood alkaline phosphatase increased 165.97 11.00 284 1338449 47795 89241919
Confusional state 165.38 11.00 4390 1334343 381815 88907899
Aggression 165.27 11.00 94 1338639 26574 89263140
Abnormal behaviour 164.49 11.00 64 1338669 22564 89267150
Dactylitis 164.24 11.00 242 1338491 3631 89286083
Psychotic disorder 164.19 11.00 132 1338601 31098 89258616
Extrapyramidal disorder 163.82 11.00 23 1338710 16280 89273434
Impaired healing 163.32 11.00 4574 1334159 229625 89060089
Temperature regulation disorder 163.11 11.00 14 1338719 14565 89275149
Pulmonary oedema 162.21 11.00 429 1338304 61651 89228063
Urinary retention 160.91 11.00 192 1338541 37552 89252162
Mobility decreased 160.07 11.00 4843 1333890 245891 89043823
Food allergy 159.06 11.00 89 1338644 25389 89264325
Parkinsonism 158.75 11.00 13 1338720 14052 89275662
Neoplasm progression 157.98 11.00 258 1338475 44228 89245486
Injection site pain 157.86 11.00 3516 1335217 170183 89119531
Schizophrenia 157.24 11.00 18 1338715 14896 89274818
Torsade de pointes 155.94 11.00 20 1338713 15162 89274552
Gastrooesophageal reflux disease 153.91 11.00 1641 1337092 164696 89125018
Pulmonary toxicity 153.67 11.00 446 1338287 11085 89278629
Malignant melanoma 153.00 11.00 471 1338262 12105 89277609
Sinus bradycardia 152.59 11.00 32 1338701 16920 89272794
Pulmonary arterial hypertension 151.58 11.00 100 1338633 26087 89263627
Vaginal flatulence 150.41 11.00 9 1338724 12629 89277085
Haemophagocytic lymphohistiocytosis 148.87 11.00 535 1338198 14924 89274790
Full blood count abnormal 148.86 11.00 193 1338540 36404 89253310
Bone marrow failure 148.75 11.00 899 1337834 31322 89258392
Blood creatinine increased 147.22 11.00 885 1337848 100501 89189213
Neutropenia 147.08 11.00 2385 1336348 222519 89067195
Off label use 146.11 11.00 18497 1320236 1083755 88205959
Foetal death 145.13 11.00 62 1338671 20661 89269053
Blood urea increased 144.89 11.00 141 1338592 30272 89259442
Diverticulitis 143.17 11.00 1150 1337583 44037 89245677
Thrombocytopenia 141.99 11.00 2197 1336536 206528 89083186
Wound 141.74 11.00 5646 1333087 297334 88992380
Bone pain 141.11 11.00 457 1338276 61526 89228188
Blood sodium decreased 141.10 11.00 120 1338613 27493 89262221
Epistaxis 140.60 11.00 712 1338021 84413 89205301
No adverse event 140.10 11.00 523 1338210 67459 89222255
Swollen tongue 139.72 11.00 293 1338440 45663 89244051
Dystonia 139.11 11.00 38 1338695 16781 89272933
Right ventricular failure 138.48 11.00 55 1338678 19150 89270564
Spinal stenosis 138.23 11.00 567 1338166 16857 89272857
Cardiogenic shock 138.19 11.00 96 1338637 24372 89265342
Myoclonus 138.04 11.00 55 1338678 19113 89270601
Immunosuppression 137.45 11.00 442 1338291 11635 89278079
Rheumatoid lung 137.36 11.00 230 1338503 3873 89285841
Acute respiratory failure 137.00 11.00 266 1338467 42652 89247062
Blood bilirubin increased 136.53 11.00 272 1338461 43198 89246516
Polyarthritis 136.12 11.00 585 1338148 17765 89271949
Swelling face 135.75 11.00 678 1338055 80674 89209040
Akathisia 135.73 11.00 7 1338726 11152 89278562
Procedural pain 134.59 11.00 177 1338556 33183 89256531
Injection site bruising 134.35 11.00 1271 1337462 51036 89238678
Paraesthesia 133.15 11.00 2752 1335981 247574 89042140
Hepatotoxicity 133.13 11.00 1144 1337589 44698 89245016
Irritability 131.20 11.00 202 1338531 35460 89254254
Infusion site pain 130.54 11.00 64 1338669 19674 89270040
Drug ineffective for unapproved indication 130.53 11.00 1533 1337200 65111 89224603
Melaena 130.05 11.00 195 1338538 34602 89255112
Abortion spontaneous 129.81 11.00 389 1338344 53667 89236047
Enthesopathy 129.45 11.00 368 1338365 9036 89280678
Emotional distress 128.91 11.00 214 1338519 36448 89253266
Dermatitis atopic 128.75 11.00 95 1338638 23377 89266337
Mania 128.50 11.00 26 1338707 14098 89275616
Chronic sinusitis 128.42 11.00 98 1338635 23704 89266010
Rectal haemorrhage 127.24 11.00 709 1338024 82035 89207679
Transfusion 126.23 11.00 50 1338683 17438 89272276
Arthrodesis 125.99 11.00 187 1338546 2825 89286889
Sinus tachycardia 125.92 11.00 141 1338592 28372 89261342
Nightmare 125.69 11.00 83 1338650 21642 89268072
Miosis 125.57 11.00 3 1338730 9481 89280233
Venoocclusive liver disease 125.24 11.00 275 1338458 5718 89283996
Depression 125.21 11.00 3430 1335303 297171 88992543
Hypersensitivity 125.10 11.00 8050 1330683 446627 88843087
Pulmonary mass 124.80 11.00 790 1337943 27982 89261732
Memory impairment 124.57 11.00 2105 1336628 195139 89094575
Heart rate increased 123.45 11.00 1069 1337664 111833 89177881
Anti-cyclic citrullinated peptide antibody positive 123.21 11.00 4459 1334274 231974 89057740
Febrile bone marrow aplasia 122.48 11.00 369 1338364 9369 89280345
Product quality issue 122.36 11.00 679 1338054 78646 89211068
Joint destruction 122.18 11.00 453 1338280 12834 89276880
Hospice care 121.57 11.00 5 1338728 9699 89280015
Rash maculo-papular 121.09 11.00 265 1338468 40668 89249046
Lymphocyte count decreased 121.01 11.00 207 1338526 34843 89254871
Tardive dyskinesia 120.91 11.00 11 1338722 10919 89278795
Hypocalcaemia 120.68 11.00 280 1338453 42088 89247626
Depressed mood 120.17 11.00 362 1338371 49860 89239854
Complication of device insertion 119.60 11.00 9 1338724 10427 89279287
Synovial cyst 119.44 11.00 414 1338319 11338 89278376
Wrong technique in product usage process 119.13 11.00 597 1338136 70974 89218740
Muscle rigidity 118.97 11.00 32 1338701 14277 89275437
Dysphagia 118.83 11.00 1072 1337661 111206 89178508
Altered state of consciousness 118.52 11.00 176 1338557 31356 89258358
Upper gastrointestinal haemorrhage 118.44 11.00 99 1338634 22877 89266837
Rhinitis allergic 117.90 11.00 50 1338683 16735 89272979
Sleep disorder due to a general medical condition 117.76 11.00 308 1338425 44430 89245284
Anhedonia 117.55 11.00 15 1338718 11416 89278298
Hypomania 117.09 11.00 3 1338730 8894 89280820
Joint injury 116.71 11.00 855 1337878 31809 89257905
Mycobacterium tuberculosis complex test positive 116.27 11.00 167 1338566 2445 89287269
Hypersensitivity pneumonitis 116.10 11.00 209 1338524 3739 89285975
Shoulder arthroplasty 115.51 11.00 215 1338518 3951 89285763
Demyelination 115.44 11.00 322 1338411 7818 89281896
Chills 115.34 11.00 1319 1337414 130662 89159052
Eye pruritus 115.08 11.00 156 1338577 28871 89260843
Blood glucose decreased 114.68 11.00 106 1338627 23323 89266391
Deafness transitory 114.35 11.00 146 1338587 1897 89287817
Poisoning 114.03 11.00 41 1338692 15176 89274538
Injection site erythema 113.83 11.00 2067 1336666 96435 89193279
Oedema 113.71 11.00 2178 1336555 198117 89091597
Lip swelling 113.36 11.00 251 1338482 38359 89251355
Accidental exposure to product 112.80 11.00 290 1338443 42076 89247638
Osteoporosis 112.74 11.00 2029 1336704 94502 89195212
Eczema 112.73 11.00 401 1338332 52469 89237245
Presyncope 112.43 11.00 185 1338548 31620 89258094
Mucosal ulceration 112.23 11.00 110 1338623 1043 89288671
Finger deformity 111.83 11.00 851 1337882 32046 89257668
Hepatic steatosis 111.53 11.00 930 1337803 36015 89253699
Hypophosphataemia 111.35 11.00 40 1338693 14814 89274900
Bone erosion 111.19 11.00 1236 1337497 51785 89237929
Premature labour 111.05 11.00 30 1338703 13346 89276368
Fine motor skill dysfunction 110.24 11.00 246 1338487 5173 89284541
Urinary tract infection 110.22 11.00 3556 1335177 302076 88987638
Nasal polyps 110.15 11.00 15 1338718 10865 89278849
Thrombosis 109.74 11.00 633 1338100 72618 89217096
Chronic obstructive pulmonary disease 109.00 11.00 641 1338092 73188 89216526
Impaired work ability 108.96 11.00 569 1338164 18757 89270957
Panniculitis 108.85 11.00 463 1338270 13995 89275719
Pulmonary fibrosis 108.59 11.00 2210 1336523 105293 89184421
Status epilepticus 107.99 11.00 73 1338660 18801 89270913
Hypothyroidism 107.99 11.00 411 1338322 52716 89236998
Latent tuberculosis 107.98 11.00 173 1338560 2803 89286911
Female genital tract fistula 107.87 11.00 65 1338668 17803 89271911
Cytokine release syndrome 107.24 11.00 154 1338579 27819 89261895
Circulatory collapse 106.89 11.00 126 1338607 24778 89264936
Deep vein thrombosis 106.73 11.00 853 1337880 90767 89198947
Pallor 106.25 11.00 215 1338518 33950 89255764
Injection site pruritus 106.16 11.00 1240 1337493 52594 89237120
Ill-defined disorder 106.07 11.00 3526 1335207 181365 89108349
Rash erythematous 105.55 11.00 548 1338185 64556 89225158
Foot operation 104.78 11.00 332 1338401 8669 89281045
Abdominal distension 104.67 11.00 1330 1337403 129271 89160443
Speech disorder 104.53 11.00 335 1338398 45250 89244464
Oral herpes 104.48 11.00 850 1337883 32674 89257040
Electrolyte imbalance 104.22 11.00 118 1338615 23627 89266087
Device difficult to use 104.06 11.00 65 1338668 17460 89272254
Infusion site erythema 103.86 11.00 36 1338697 13634 89276080
Feeling abnormal 103.24 11.00 1792 1336941 165443 89124271
Foetal methotrexate syndrome 103.04 11.00 45 1338688 73 89289641
Complication associated with device 102.50 11.00 82 1338651 19367 89270347
Urinary incontinence 102.45 11.00 254 1338479 37312 89252402
Myelopathy 102.15 11.00 183 1338550 3261 89286453
Rash 101.01 11.00 13327 1325406 782773 88506941
Graft versus host disease 100.93 11.00 307 1338426 7837 89281877
Hypothermia 100.75 11.00 52 1338681 15523 89274191
Cardiac disorder 100.70 11.00 464 1338269 56408 89233306
Mydriasis 100.31 11.00 48 1338685 14964 89274750
Vaginal discharge 100.17 11.00 84 1338649 19380 89270334
Product administration interrupted 100.04 11.00 30 1338703 12462 89277252
Hallucination, auditory 99.44 11.00 56 1338677 15919 89273795
Pericarditis 99.34 11.00 4912 1333821 265239 89024475
Arrhythmia 97.83 11.00 310 1338423 42022 89247692
Extranodal marginal zone B-cell lymphoma (MALT type) 97.56 11.00 75 1338658 494 89289220
Elbow deformity 95.86 11.00 115 1338618 1396 89288318
Dementia 95.85 11.00 127 1338606 23734 89265980
Hepatic fibrosis 95.80 11.00 199 1338534 3976 89285738
Ejection fraction decreased 95.34 11.00 150 1338583 26103 89263611
Respiratory distress 95.15 11.00 278 1338455 38668 89251046
Electrocardiogram QRS complex prolonged 94.78 11.00 3 1338730 7345 89282369
Head injury 94.68 11.00 199 1338534 30989 89258725
Joint arthroplasty 94.60 11.00 178 1338555 3299 89286415
Acute generalised exanthematous pustulosis 94.37 11.00 42 1338691 13661 89276053
Mucocutaneous ulceration 94.35 11.00 54 1338679 197 89289517
Tubulointerstitial nephritis 93.76 11.00 143 1338590 25200 89264514
Eosinophilia 93.56 11.00 174 1338559 28359 89261355
Paranoia 93.02 11.00 37 1338696 12871 89276843
Pharyngitis 92.96 11.00 599 1338134 21348 89268366
Acute myocardial infarction 92.75 11.00 239 1338494 34651 89255063
Mycobacterium marinum infection 92.33 11.00 57 1338676 247 89289467
Cerebral haemorrhage 92.14 11.00 236 1338497 34286 89255428
Generalised tonic-clonic seizure 92.09 11.00 240 1338493 34663 89255051
Blood creatine phosphokinase increased 92.04 11.00 231 1338502 33792 89255922
Aphthous ulcer 91.35 11.00 500 1338233 16787 89272927
Acute graft versus host disease in intestine 91.00 11.00 132 1338601 1951 89287763
Metastases to bone 90.48 11.00 148 1338585 25357 89264357
Pleural effusion 90.29 11.00 1139 1337594 110852 89178862
Neuroendocrine carcinoma of the skin 89.44 11.00 85 1338648 773 89288941
Product preparation error 89.07 11.00 21 1338712 10240 89279474
Eye irritation 88.61 11.00 235 1338498 33743 89255971
Hodgkin's disease 88.60 11.00 80 1338653 677 89289037
Vascular device infection 88.21 11.00 33 1338700 11919 89277795
Exposure to toxic agent 88.18 11.00 8 1338725 7959 89281755
Insomnia 88.04 11.00 4026 1334707 329448 88960266
Therapy interrupted 87.43 11.00 411 1338322 49697 89240017
Flatulence 87.37 11.00 315 1338418 41052 89248662
Proctitis 87.33 11.00 59 1338674 15200 89274514
Myocardial infarction 87.23 11.00 1073 1337660 104899 89184815
Sensitivity to weather change 87.12 11.00 310 1338423 8604 89281110
Exposure via skin contact 87.02 11.00 25 1338708 10680 89279034
Visceral leishmaniasis 86.82 11.00 74 1338659 575 89289139
Atrial septal defect 86.65 11.00 10 1338723 8224 89281490
Injection site warmth 86.20 11.00 497 1338236 17018 89272696
Haematoma 86.06 11.00 292 1338441 38756 89250958
Spondyloarthropathy 85.72 11.00 98 1338635 1126 89288588
Jaundice 85.48 11.00 224 1338509 32293 89257421
Cataract 85.47 11.00 1519 1337214 70573 89219141
Treatment noncompliance 85.21 11.00 433 1338300 51294 89238420
Ulcer 84.94 11.00 800 1337933 32082 89257632
Leukocytosis 84.93 11.00 209 1338524 30781 89258933
Insurance issue 84.75 11.00 28 1338705 10930 89278784
Chronic graft versus host disease in skin 84.68 11.00 98 1338635 1142 89288572
Folliculitis 84.59 11.00 3760 1334973 200593 89089121
Inappropriate antidiuretic hormone secretion 84.45 11.00 98 1338635 19407 89270307
Blood magnesium decreased 84.17 11.00 65 1338668 15628 89274086
Immobile 83.85 11.00 246 1338487 6152 89283562
Transplant rejection 83.42 11.00 42 1338691 12716 89276998
Dysuria 83.23 11.00 300 1338433 39101 89250613
Hypofibrinogenaemia 83.22 11.00 102 1338631 1268 89288446
Erythema 83.15 11.00 2665 1336068 226581 89063133
Product substitution issue 82.91 11.00 86 1338647 17922 89271792
Limb deformity 82.81 11.00 187 1338546 3965 89285749
Atrioventricular block 82.80 11.00 15 1338718 8800 89280914
Stevens-Johnson syndrome 82.18 11.00 196 1338537 29180 89260534
Hepatic encephalopathy 81.88 11.00 51 1338682 13721 89275993
Cholecystitis chronic 81.65 11.00 22 1338711 9804 89279910
Red blood cell count decreased 80.98 11.00 380 1338353 45971 89243743
Sacroiliitis 80.80 11.00 187 1338546 4032 89285682
Jaundice cholestatic 80.64 11.00 24 1338709 10019 89279695
Delirium 80.58 11.00 1071 1337662 103288 89186426
Multiple drug therapy 80.45 11.00 6 1338727 7003 89282711
Gestational diabetes 80.17 11.00 28 1338705 10554 89279160
Anuria 79.96 11.00 61 1338672 14757 89274957
Abnormal dreams 79.92 11.00 33 1338700 11224 89278490
Delusion 79.90 11.00 53 1338680 13787 89275927
Oxygen saturation decreased 79.77 11.00 1112 1337621 106371 89183343
Headache 79.59 11.00 11353 1327380 851393 88438321
Dysarthria 79.38 11.00 475 1338258 54007 89235707
Atrioventricular block first degree 78.84 11.00 15 1338718 8496 89281218
Pulseless electrical activity 78.09 11.00 18 1338715 8914 89280800
Troponin increased 77.84 11.00 50 1338683 13231 89276483
Hot flush 77.81 11.00 536 1338197 58952 89230762
Discomfort 77.69 11.00 4870 1333863 269465 89020249
Ascites 76.18 11.00 404 1338329 47336 89242378
Chromaturia 76.18 11.00 103 1338630 19084 89270630
Hyperthyroidism 76.08 11.00 95 1338638 18215 89271499
Tibia fracture 75.94 11.00 230 1338503 5857 89283857
Complication of device removal 75.84 11.00 4 1338729 6251 89283463
Grip strength decreased 75.75 11.00 1847 1336886 90729 89198985
Atypical mycobacterial infection 75.39 11.00 106 1338627 1520 89288194
Sleep apnoea syndrome 75.12 11.00 230 1338503 31517 89258197
Investigation abnormal 74.96 11.00 127 1338606 2160 89287554
Retching 74.91 11.00 104 1338629 19055 89270659
Neurotoxicity 74.47 11.00 558 1338175 20909 89268805
Histoplasmosis 74.39 11.00 124 1338609 2080 89287634
Pollakiuria 73.97 11.00 245 1338488 32760 89256954
Liver function test abnormal 73.93 11.00 1108 1337625 49737 89239977
Joint range of motion decreased 73.78 11.00 2571 1336162 133072 89156642
Dissociation 73.64 11.00 7 1338726 6708 89283006
Tinnitus 73.18 11.00 357 1338376 42745 89246969
Infusion site swelling 73.07 11.00 41 1338692 11679 89278035
Lip ulceration 72.72 11.00 123 1338610 2089 89287625
Somnambulism 72.44 11.00 5 1338728 6223 89283491
Inflammatory marker increased 72.43 11.00 299 1338434 8915 89280799
Acute lymphocytic leukaemia recurrent 72.43 11.00 138 1338595 2583 89287131
Chronic kidney disease 72.38 11.00 439 1338294 49752 89239962
Euglycaemic diabetic ketoacidosis 72.06 11.00 5 1338728 6196 89283518
Lymph node tuberculosis 71.81 11.00 74 1338659 749 89288965
Ventricular fibrillation 71.80 11.00 61 1338672 13983 89275731
Graft versus host disease in gastrointestinal tract 71.76 11.00 183 1338550 4205 89285509
Epstein-Barr virus associated lymphoma 71.64 11.00 69 1338664 639 89289075
Wrist deformity 71.58 11.00 152 1338581 3086 89286628
Localised infection 71.11 11.00 784 1337949 32778 89256936
Pruritus 71.04 11.00 6960 1331773 534565 88755149
Moebius II syndrome 70.66 11.00 23 1338710 4 89289710
Ovarian hyperstimulation syndrome 70.29 11.00 4 1338729 5858 89283856
Hip arthroplasty 70.25 11.00 1546 1337187 74662 89215052
Haemorrhage 70.08 11.00 670 1338063 68699 89221015
Osteoporotic fracture 69.80 11.00 190 1338543 4546 89285168
Muscle injury 69.33 11.00 3233 1335500 173421 89116293
Acute hepatic failure 69.29 11.00 143 1338590 22418 89267296
Infusion site pruritus 69.27 11.00 9 1338724 6756 89282958
Dermatitis psoriasiform 69.26 11.00 134 1338599 2538 89287176
Mood altered 69.12 11.00 91 1338642 17053 89272661
Tachypnoea 68.94 11.00 131 1338602 21178 89268536
Therapy non-responder 68.93 11.00 2569 1336164 134135 89155579
Hypovolaemia 68.59 11.00 50 1338683 12381 89277333
Uterine perforation 68.53 11.00 14 1338719 7540 89282174
Blood calcium increased 68.51 11.00 47 1338686 12011 89277703
Device use error 68.45 11.00 12 1338721 7209 89282505
Haematocrit decreased 68.43 11.00 351 1338382 41481 89248233
Pre-eclampsia 68.38 11.00 39 1338694 11009 89278705
Mental disorder 68.31 11.00 246 1338487 32072 89257642
Cyanosis 67.99 11.00 114 1338619 19341 89270373
Irritable bowel syndrome 67.93 11.00 3731 1335002 203717 89085997
Dialysis 67.29 11.00 42 1338691 11287 89278427
Skin lesion 67.28 11.00 846 1337887 36519 89253195
Skin erosion 67.09 11.00 152 1338581 3230 89286484
Lung disorder 66.98 11.00 2780 1335953 147103 89142611
Diabetes mellitus inadequate control 66.67 11.00 108 1338625 18576 89271138
Glycosylated haemoglobin increased 66.51 11.00 79 1338654 15483 89274231
Bronchospasm 66.40 11.00 128 1338605 20581 89269133
Feeling hot 66.05 11.00 785 1337948 77223 89212491
Hypoaesthesia oral 65.81 11.00 80 1338653 15520 89274194
Epidermal necrosis 65.65 11.00 122 1338611 2239 89287475
Lung adenocarcinoma 65.46 11.00 206 1338527 5359 89284355
Anaphylactic shock 65.29 11.00 243 1338490 31374 89258340
Retinal toxicity 64.89 11.00 92 1338641 1330 89288384
Haematemesis 64.67 11.00 267 1338466 33459 89256255
Product physical issue 64.53 11.00 5 1338728 5655 89284059
Graft versus host disease in skin 64.38 11.00 162 1338571 3691 89286023
Scleritis 64.24 11.00 196 1338537 5012 89284702
Granuloma skin 64.09 11.00 320 1338413 10360 89279354
Hereditary angioedema 64.03 11.00 29 1338704 9336 89280378
Unintended pregnancy 63.64 11.00 17 1338716 7620 89282094
Hypercapnia 63.51 11.00 11 1338722 6666 89283048
Fear 63.23 11.00 92 1338641 16530 89273184
Faecal calprotectin increased 62.85 11.00 164 1338569 3823 89285891
Bradykinesia 62.80 11.00 12 1338721 6776 89282938
Dermatitis allergic 62.73 11.00 455 1338278 16872 89272842
Cutaneous T-cell lymphoma 62.69 11.00 97 1338636 1523 89288191
Aspiration 62.55 11.00 84 1338649 15609 89274105
Device breakage 62.51 11.00 69 1338664 13975 89275739
Ventricular extrasystoles 62.46 11.00 62 1338671 13188 89276526
Salivary hypersecretion 62.41 11.00 28 1338705 9064 89280650
Ankle deformity 62.14 11.00 54 1338679 432 89289282
Ageusia 62.12 11.00 88 1338645 15988 89273726
Product administration error 62.11 11.00 192 1338541 26231 89263483
Toxic epidermal necrolysis 62.07 11.00 258 1338475 32270 89257444
Tonsillitis 61.92 11.00 235 1338498 6734 89282980
Eye swelling 61.90 11.00 224 1338509 29162 89260552
Fibromyalgia 61.78 11.00 3680 1335053 202589 89087125
Musculoskeletal deformity 61.69 11.00 105 1338628 1793 89287921
Psychomotor hyperactivity 61.50 11.00 59 1338674 12754 89276960
Incorrect product administration duration 61.45 11.00 120 1338613 19202 89270512
Hyperprolactinaemia 61.38 11.00 5 1338728 5428 89284286
Sickle cell anaemia with crisis 61.27 11.00 16 1338717 7281 89282433
Stillbirth 61.21 11.00 17 1338716 7426 89282288
Genital haemorrhage 61.00 11.00 26 1338707 8676 89281038
Blood potassium increased 60.82 11.00 135 1338598 20614 89269100
Rheumatoid factor negative 60.80 11.00 59 1338674 552 89289162
Lennox-Gastaut syndrome 60.78 11.00 44 1338689 261 89289453
Blood pressure systolic abnormal 60.77 11.00 494 1338239 18984 89270730
Acidosis 60.72 11.00 59 1338674 12677 89277037
Respiratory acidosis 60.63 11.00 22 1338711 8097 89281617
Posterior reversible encephalopathy syndrome 60.47 11.00 549 1338184 21790 89267924
Central nervous system lymphoma 60.32 11.00 109 1338624 1956 89287758
Epicondylitis 59.94 11.00 124 1338609 2470 89287244
SLE arthritis 59.93 11.00 63 1338670 654 89289060
Catatonia 59.79 11.00 9 1338724 6047 89283667
Blood loss anaemia 59.67 11.00 38 1338695 10102 89279612
Chemotherapeutic drug level increased 59.33 11.00 38 1338695 178 89289536
Pneumonia legionella 59.10 11.00 103 1338630 1794 89287920
Transaminases increased 59.03 11.00 823 1337910 36369 89253345
Body height below normal 59.00 11.00 111 1338622 2057 89287657
Gamma-glutamyltransferase increased 58.99 11.00 324 1338409 37628 89252086
Bronchitis chronic 58.97 11.00 179 1338554 4564 89285150
Disease recurrence 58.88 11.00 831 1337902 36822 89252892
Blood pressure fluctuation 58.84 11.00 1095 1337638 51318 89238396
Ischaemic stroke 58.80 11.00 152 1338581 22014 89267700
Skin plaque 58.54 11.00 297 1338436 9678 89280036
Hepatic enzyme abnormal 58.52 11.00 246 1338487 7396 89282318
Nausea 58.47 11.00 15044 1323689 1095272 88194442
Liver disorder 58.29 11.00 2267 1336466 119002 89170712
Infusion related reaction 58.05 11.00 7019 1331714 409761 88879953
Foot fracture 57.98 11.00 625 1338108 25981 89263733
Arthritis infective 57.91 11.00 253 1338480 7739 89281975
Blood pressure diastolic abnormal 57.65 11.00 496 1338237 19385 89270329
Haemoptysis 57.13 11.00 275 1338458 33045 89256669
Heparin-induced thrombocytopenia 57.04 11.00 6 1338727 5306 89284408
Transient ischaemic attack 56.97 11.00 388 1338345 42788 89246926
Foetal growth restriction 56.80 11.00 34 1338699 9346 89280368
Low birth weight baby 56.37 11.00 35 1338698 9432 89280282
End stage renal disease 56.36 11.00 28 1338705 8543 89281171
Pregnancy with contraceptive device 56.31 11.00 5 1338728 5061 89284653
Vertigo 56.27 11.00 710 1338023 69101 89220613
Neck pain 56.09 11.00 2136 1336597 111827 89177887
Hypotonia 55.56 11.00 52 1338681 11374 89278340
Hepatitis B reactivation 55.18 11.00 156 1338577 3818 89285896
Cytomegalovirus chorioretinitis 55.16 11.00 115 1338618 2304 89287410
Pyoderma gangrenosum 55.06 11.00 168 1338565 4296 89285418
Non-Hodgkin's lymphoma 55.06 11.00 84 1338649 1302 89288412
Palmoplantar pustulosis 55.01 11.00 56 1338677 558 89289156
Hyperlipidaemia 54.95 11.00 165 1338568 22751 89266963
Dysphonia 54.88 11.00 631 1338102 62453 89227261
Panic attack 54.86 11.00 202 1338531 26163 89263551
Atrioventricular block complete 54.74 11.00 39 1338694 9772 89279942
Adult T-cell lymphoma/leukaemia 54.70 11.00 39 1338694 225 89289489
Oral mucosa erosion 54.63 11.00 87 1338646 1402 89288312
Varicella zoster virus infection 54.62 11.00 153 1338580 3724 89285990
Non-alcoholic steatohepatitis 54.54 11.00 99 1338634 1783 89287931
Coronary artery disease 54.51 11.00 283 1338450 33340 89256374
Drug specific antibody 54.47 11.00 117 1338616 2395 89287319
Increased appetite 54.37 11.00 56 1338677 11709 89278005
Ileocaecal resection 54.36 11.00 53 1338680 499 89289215
Disability assessment scale score increased 54.27 11.00 154 1338579 3777 89285937
Nasal oedema 54.22 11.00 15 1338718 6569 89283145
Adverse reaction 54.04 11.00 674 1338059 29038 89260676
Tenderness 53.92 11.00 621 1338112 26247 89263467
Temporal lobe epilepsy 53.89 11.00 47 1338686 378 89289336
Epstein-Barr virus infection reactivation 53.78 11.00 91 1338642 1546 89288168
Haemorrhage intracranial 53.77 11.00 88 1338645 15074 89274640
Epilepsy 53.60 11.00 872 1337861 81334 89208380
Mesenteritis 53.58 11.00 43 1338690 304 89289410
Clonus 53.55 11.00 10 1338723 5740 89283974
Infusion site haemorrhage 53.52 11.00 8 1338725 5403 89284311
Iritis 53.45 11.00 147 1338586 3539 89286175
Bradypnoea 53.43 11.00 4 1338729 4654 89285060
Bicytopenia 53.31 11.00 149 1338584 3622 89286092
Hyperreflexia 53.29 11.00 16 1338717 6641 89283073
Throat tightness 53.12 11.00 239 1338494 29245 89260469
Total lung capacity increased 53.08 11.00 6 1338727 5015 89284699
Skin necrosis 53.03 11.00 430 1338303 16511 89273203
Bradyphrenia 52.95 11.00 23 1338710 7589 89282125
Nervousness 52.79 11.00 291 1338442 33765 89255949
Joint space narrowing 52.64 11.00 60 1338673 687 89289027
Angioimmunoblastic T-cell lymphoma 52.63 11.00 37 1338696 208 89289506
Pneumonitis 52.47 11.00 931 1337802 43239 89246475
Skin cancer 52.45 11.00 361 1338372 13158 89276556
Systemic infection 52.30 11.00 5 1338728 4770 89284944
Bone disorder 52.20 11.00 547 1338186 22573 89267141
Anger 52.13 11.00 76 1338657 13644 89276070
Anal abscess 51.98 11.00 194 1338539 5514 89284200
Hepatosplenic T-cell lymphoma 51.72 11.00 57 1338676 627 89289087
Drug dose omission by device 51.62 11.00 45 1338688 10186 89279528
Amnesia 51.57 11.00 1214 1337519 107291 89182423
Induced abortion failed 51.25 11.00 34 1338699 171 89289543
Glaucoma 51.16 11.00 500 1338233 20255 89269459
Synovectomy 51.15 11.00 35 1338698 187 89289527
Electrocardiogram abnormal 51.11 11.00 46 1338687 10252 89279462
Blood parathyroid hormone decreased 50.87 11.00 332 1338401 11884 89277830
Unevaluable event 50.74 11.00 541 1338192 54307 89235407
Metastases to central nervous system 50.71 11.00 115 1338618 17427 89272287
Embedded device 50.63 11.00 3 1338730 4245 89285469
Spinal column injury 50.63 11.00 104 1338629 2061 89287653
Respiratory failure 50.33 11.00 1347 1337386 117071 89172643
Injection site swelling 50.20 11.00 1198 1337535 58641 89231073
Hepatitis 49.92 11.00 1384 1337349 69355 89220359
Blood pressure inadequately controlled 49.75 11.00 15 1338718 6209 89283505
Muscle tightness 49.55 11.00 76 1338657 13363 89276351
Ketoacidosis 49.47 11.00 11 1338722 5584 89284130
Sleep disorder due to general medical condition, insomnia type 49.35 11.00 2350 1336383 126344 89163370
Dizziness postural 49.19 11.00 37 1338696 9016 89280698
Psoriasis area severity index increased 49.00 11.00 32 1338701 156 89289558
Adactyly 48.86 11.00 21 1338712 32 89289682
Leukaemia recurrent 48.80 11.00 82 1338651 1385 89288329
Underdose 48.69 11.00 536 1338197 53481 89236233
Faeces discoloured 48.65 11.00 157 1338576 21163 89268551
Thinking abnormal 48.61 11.00 61 1338672 11671 89278043
Cutaneous leishmaniasis 48.52 11.00 27 1338706 92 89289622
Oligohydramnios 48.15 11.00 23 1338710 7178 89282536
Glomerular filtration rate decreased 48.14 11.00 112 1338621 16820 89272894
Pneumonia cryptococcal 48.05 11.00 74 1338659 1157 89288557
Pre-existing condition improved 47.89 11.00 39 1338694 9130 89280584
Hip fracture 47.86 11.00 289 1338444 32788 89256926
Device occlusion 47.84 11.00 40 1338693 9242 89280472
Pleurisy 47.64 11.00 265 1338468 8952 89280762
Metabolic encephalopathy 47.60 11.00 20 1338713 6732 89282982
Intervertebral disc protrusion 47.37 11.00 612 1338121 26584 89263130
Intestinal obstruction 47.36 11.00 337 1338396 36794 89252920
Rash macular 47.34 11.00 258 1338475 30022 89259692
Shock 47.34 11.00 241 1338492 28537 89261177
Ileal ulcer 47.22 11.00 68 1338665 998 89288716
Pustular psoriasis 47.20 11.00 450 1338283 18106 89271608
Patent ductus arteriosus 46.97 11.00 6 1338727 4563 89285151
Initial insomnia 46.91 11.00 41 1338692 9269 89280445
Extrapulmonary tuberculosis 46.81 11.00 43 1338690 373 89289341
Granulomatous pneumonitis 46.76 11.00 32 1338701 171 89289543
Lacrimation increased 46.60 11.00 223 1338510 26839 89262875
Thyroid neoplasm 46.52 11.00 148 1338585 3873 89285841
Hypernatraemia 46.50 11.00 42 1338691 9345 89280369
Rheumatoid vasculitis 46.45 11.00 43 1338690 377 89289337
Haematotoxicity 46.44 11.00 331 1338402 12204 89277510
Leukopenia 46.14 11.00 1873 1336860 98837 89190877
Diffuse large B-cell lymphoma stage IV 46.13 11.00 40 1338693 319 89289395
Small for dates baby 46.01 11.00 9 1338724 4998 89284716
Colitis 45.90 11.00 741 1337992 69201 89220513
Wrist surgery 45.90 11.00 63 1338670 882 89288832
Subarachnoid haemorrhage 45.80 11.00 125 1338608 17779 89271935
Renal tubular necrosis 45.77 11.00 91 1338642 14464 89275250
Surgical failure 45.66 11.00 64 1338669 915 89288799
Hallucinations, mixed 45.63 11.00 15 1338718 5874 89283840
Neutrophil count increased 45.50 11.00 141 1338592 19249 89270465
Atrioventricular block second degree 45.40 11.00 6 1338727 4446 89285268
Erythema multiforme 45.40 11.00 69 1338664 12177 89277537
Pregnancy 45.30 11.00 644 1338089 61403 89228311
Respiration abnormal 45.29 11.00 31 1338702 7932 89281782
Mycobacterium haemophilum infection 45.24 11.00 32 1338701 182 89289532
Taste disorder 45.21 11.00 638 1338095 60908 89228806
Gastrointestinal pain 45.12 11.00 302 1338431 10904 89278810
Personality change 45.09 11.00 26 1338707 7295 89282419
Cholestasis 45.06 11.00 332 1338401 35967 89253747
Subdural haematoma 45.03 11.00 113 1338620 16532 89273182
Blood lactic acid increased 45.03 11.00 38 1338695 8740 89280974
Spinal pain 45.00 11.00 392 1338341 15375 89274339
Mycobacterium chelonae infection 44.99 11.00 52 1338681 605 89289109
Oxygen consumption increased 44.90 11.00 7 1338726 4582 89285132
Systemic lupus erythematosus rash 44.78 11.00 105 1338628 2284 89287430
Catheter site erythema 44.54 11.00 9 1338724 4885 89284829
Malignant respiratory tract neoplasm 44.54 11.00 20 1338713 36 89289678
Rotator cuff syndrome 44.51 11.00 394 1338339 15525 89274189
Squamous cell carcinoma of lung 44.47 11.00 66 1338667 997 89288717
Infective tenosynovitis 44.33 11.00 41 1338692 359 89289355
Restless legs syndrome 44.27 11.00 176 1338557 22294 89267420
Tricuspid valve incompetence 44.17 11.00 115 1338618 16616 89273098
Seasonal allergy 44.04 11.00 182 1338551 22801 89266913
Bronchitis 44.03 11.00 2719 1336014 150208 89139506
Infection reactivation 43.97 11.00 92 1338641 1848 89287866
Visual impairment 43.69 11.00 1557 1337176 130808 89158906
Toxic skin eruption 43.53 11.00 106 1338627 15668 89274046
Migraine 43.49 11.00 2333 1336400 188059 89101655
Faecaloma 43.47 11.00 54 1338679 10377 89279337
Nasal ulcer 43.41 11.00 111 1338622 2555 89287159
Retinal pigment epitheliopathy 43.34 11.00 35 1338698 250 89289464
Incorrect dose administered 43.32 11.00 863 1337870 78067 89211647
Human antichimeric antibody positive 43.19 11.00 87 1338646 1699 89288015
Psychomotor retardation 43.19 11.00 9 1338724 4780 89284934
Amyotrophic lateral sclerosis 43.06 11.00 74 1338659 1274 89288440
Acute coronary syndrome 42.98 11.00 58 1338675 10755 89278959
Cardiac murmur 42.91 11.00 132 1338601 18062 89271652
Blood pressure diastolic increased 42.82 11.00 332 1338401 12574 89277140
Product complaint 42.80 11.00 84 1338649 13416 89276298
Haematuria 42.68 11.00 321 1338412 34616 89255098
Application site erythema 42.64 11.00 12 1338721 5196 89284518
Asthma-chronic obstructive pulmonary disease overlap syndrome 42.58 11.00 10 1338723 4889 89284825
Tendon disorder 42.53 11.00 204 1338529 6496 89283218
Rales 42.39 11.00 108 1338625 15719 89273995
Injection site haemorrhage 42.30 11.00 620 1338113 27698 89262016
Oral mucosal exfoliation 42.21 11.00 86 1338647 1694 89288020
Drooling 42.13 11.00 8 1338725 4538 89285176
Growth retardation 42.11 11.00 86 1338647 1697 89288017
Tendon rupture 42.09 11.00 257 1338476 8986 89280728
Urine output decreased 42.08 11.00 76 1338657 12527 89277187
Blood prolactin increased 42.07 11.00 3 1338730 3634 89286080
Ocular hyperaemia 42.02 11.00 309 1338424 33489 89256225
Tonsillar ulcer 42.01 11.00 36 1338697 282 89289432
Bone swelling 42.00 11.00 85 1338648 1666 89288048
Pericardial effusion 41.93 11.00 345 1338388 36488 89253226
Adverse drug reaction 41.82 11.00 2117 1336616 114584 89175130
Cervical dysplasia 41.77 11.00 143 1338590 3891 89285823
Pancreatitis acute 41.68 11.00 290 1338443 31825 89257889
Bronchial carcinoma 41.67 11.00 55 1338678 740 89288974
Extra dose administered 41.47 11.00 44 1338689 9074 89280640
Skin papilloma 41.38 11.00 179 1338554 5451 89284263
Alveolitis 41.37 11.00 118 1338615 2903 89286811
Supraventricular tachycardia 41.08 11.00 115 1338618 16221 89273493
Diplopia 40.96 11.00 252 1338481 28462 89261252
Stress fracture 40.86 11.00 242 1338491 8369 89281345
Cholelithiasis 40.83 11.00 538 1338195 51968 89237746
Peritoneal tuberculosis 40.80 11.00 46 1338687 520 89289194
Thirst 40.77 11.00 115 1338618 16180 89273534
Proteinuria 40.65 11.00 191 1338542 23100 89266614
Tuberculous pleurisy 40.63 11.00 41 1338692 404 89289310
Weight decreased 40.58 11.00 4952 1333781 374958 88914756
Granuloma 40.48 11.00 190 1338543 5995 89283719
Complications of bone marrow transplant 40.47 11.00 42 1338691 429 89289285
Blister 40.42 11.00 4331 1334402 250667 89039047
Mental impairment 40.37 11.00 120 1338613 16600 89273114
Peritonitis bacterial 40.37 11.00 13 1338720 5158 89284556
Hypersomnia 40.33 11.00 172 1338561 21359 89268355
Device leakage 40.31 11.00 53 1338680 9938 89279776
Squamous cell carcinoma of the oral cavity 40.27 11.00 40 1338693 386 89289328
Oliguria 40.22 11.00 59 1338674 10565 89279149
Plasma cell myeloma recurrent 40.14 11.00 7 1338726 4221 89285493
Rheumatoid factor increased 39.90 11.00 101 1338632 2310 89287404
Hepatosplenomegaly 39.73 11.00 116 1338617 2893 89286821
Cancer pain 39.70 11.00 6 1338727 4019 89285695
Helicobacter infection 39.68 11.00 3879 1334854 222971 89066743
Face oedema 39.66 11.00 193 1338540 23125 89266589
Disability 39.61 11.00 833 1337900 39912 89249802
Growth failure 39.53 11.00 38 1338695 351 89289363
Joint noise 39.51 11.00 169 1338564 5121 89284593
Human herpesvirus 6 infection 39.41 11.00 126 1338607 3306 89286408
Vaginal haemorrhage 39.31 11.00 285 1338448 30986 89258728
Eosinophil count increased 39.26 11.00 84 1338649 12997 89276717
Ophthalmic herpes zoster 39.25 11.00 110 1338623 2678 89287036
Therapy change 39.16 11.00 39 1338694 8283 89281431
Erythema nodosum 39.06 11.00 178 1338555 5546 89284168
Rheumatic disorder 39.03 11.00 125 1338608 3283 89286431
Drug dependence 38.97 11.00 263 1338470 29064 89260650
Skin exfoliation 38.96 11.00 737 1337996 67176 89222538
Dermatomyositis 38.95 11.00 124 1338609 3246 89286468
Episcleritis 38.90 11.00 66 1338667 1124 89288590
Cutaneous B-cell lymphoma 38.89 11.00 18 1338715 36 89289678
Colon cancer 38.83 11.00 286 1338447 10658 89279056
Adenovirus infection 38.73 11.00 153 1338580 4469 89285245
Asphyxia 38.63 11.00 29 1338704 7074 89282640
Hyperventilation 38.52 11.00 26 1338707 6702 89283012
Pulmonary sarcoidosis 38.50 11.00 69 1338664 1230 89288484
Herpes simplex 38.40 11.00 270 1338463 9911 89279803
Blood pressure diastolic decreased 38.38 11.00 583 1338150 26243 89263471
Organising pneumonia 38.32 11.00 217 1338516 7380 89282334
Cerebral toxoplasmosis 38.32 11.00 72 1338661 1333 89288381
Application site pruritus 38.26 11.00 8 1338725 4239 89285475
Ocular lymphoma 38.20 11.00 24 1338709 108 89289606
Ventricular septal defect 38.15 11.00 16 1338717 5391 89284323
Cutaneous tuberculosis 37.93 11.00 28 1338705 172 89289542
Plantar fasciitis 37.87 11.00 144 1338589 4130 89285584
Antinuclear antibody positive 37.79 11.00 250 1338483 8991 89280723
Polyuria 37.77 11.00 56 1338677 9984 89279730
Renal injury 37.70 11.00 58 1338675 10185 89279529
Blood thyroid stimulating hormone increased 37.52 11.00 48 1338685 9107 89280607
Myelitis 37.51 11.00 90 1338643 1988 89287726
Azotaemia 37.45 11.00 16 1338717 5332 89284382
Tooth abscess 37.37 11.00 389 1338344 16024 89273690
Maternal exposure during delivery 37.33 11.00 6 1338727 3840 89285874
International normalised ratio abnormal 37.31 11.00 6 1338727 3839 89285875
Red blood cell sedimentation rate 37.28 11.00 152 1338581 4506 89285208
Prothrombin time prolonged 37.26 11.00 54 1338679 9718 89279996
Cytomegalovirus infection 37.24 11.00 576 1338157 26026 89263688
Wrong patient received product 37.15 11.00 4 1338729 3473 89286241
Myocarditis 37.14 11.00 94 1338639 13712 89276002
Mycobacterium avium complex infection 37.08 11.00 139 1338594 3959 89285755
Sleep terror 37.08 11.00 10 1338723 4454 89285260
Joint ankylosis 37.07 11.00 68 1338665 1235 89288479
Cold sweat 37.01 11.00 97 1338636 13984 89275730
Post-traumatic stress disorder 36.98 11.00 28 1338705 6800 89282914
Duodenal ulcer perforation 36.98 11.00 3772 1334961 217516 89072198
Aspartate aminotransferase increased 36.96 11.00 1198 1337535 101739 89187975
Interferon gamma release assay positive 36.95 11.00 22 1338711 88 89289626
Haematochezia 36.94 11.00 782 1337951 70131 89219583
Eructation 36.90 11.00 65 1338668 10817 89278897
Mitral valve incompetence 36.84 11.00 189 1338544 22335 89267379
Product residue present 36.82 11.00 9 1338724 4282 89285432
Synostosis 36.80 11.00 18 1338715 43 89289671
Cardiospasm 36.73 11.00 4 1338729 3442 89286272
Ovarian neoplasm 36.66 11.00 56 1338677 869 89288845
Carpal tunnel syndrome 36.57 11.00 526 1338207 23402 89266312
Acute graft versus host disease in liver 36.57 11.00 52 1338681 754 89288960
Metastases to liver 36.47 11.00 262 1338471 28545 89261169
Activated partial thromboplastin time prolonged 36.44 11.00 37 1338696 7788 89281926
Labelled drug-drug interaction medication error 36.42 11.00 103 1338630 14479 89275235
Bunion operation 36.30 11.00 69 1338664 1289 89288425
Folate deficiency 36.17 11.00 116 1338617 3049 89286665
Drug screen positive 36.15 11.00 6 1338727 3751 89285963
Bundle branch block left 35.91 11.00 38 1338695 7847 89281867
Wheelchair user 35.79 11.00 217 1338516 7568 89282146
Gait disturbance 35.69 11.00 4383 1334350 256113 89033601
C-reactive protein decreased 35.66 11.00 61 1338672 1046 89288668
Osteochondrosis 35.64 11.00 82 1338651 1761 89287953
Corneal toxicity 35.64 11.00 19 1338714 58 89289656
Gastric disorder 35.60 11.00 692 1338041 32692 89257022
Bloody discharge 35.59 11.00 93 1338640 2170 89287544
Cardiomegaly 35.56 11.00 151 1338582 18774 89270940
Disturbance in social behaviour 35.52 11.00 9 1338724 4179 89285535
Joint laxity 35.36 11.00 102 1338631 2526 89287188
Lung transplant 35.30 11.00 6 1338727 3686 89286028
Transaminases abnormal 35.29 11.00 49 1338684 694 89289020
Abortion incomplete 35.17 11.00 3 1338730 3137 89286577
Ileal stenosis 35.12 11.00 98 1338635 2380 89287334
Stress cardiomyopathy 35.10 11.00 92 1338641 13263 89276451
Lower gastrointestinal haemorrhage 35.03 11.00 48 1338685 8844 89280870
Tongue ulceration 34.95 11.00 138 1338595 4030 89285684
Ileus 34.93 11.00 126 1338607 16420 89273294
Left ventricular dysfunction 34.90 11.00 106 1338627 14563 89275151
Lyme disease 34.85 11.00 140 1338593 4122 89285592
Exercise tolerance decreased 34.83 11.00 36 1338697 7515 89282199
Mucosal toxicity 34.82 11.00 36 1338697 366 89289348
Peripheral coldness 34.79 11.00 98 1338635 13794 89275920
Performance status decreased 34.78 11.00 10 1338723 4270 89285444
Ureaplasma infection 34.76 11.00 54 1338679 851 89288863
Joint warmth 34.74 11.00 79 1338654 1683 89288031
Eye disorder 34.58 11.00 583 1338150 26807 89262907
Peripheral T-cell lymphoma unspecified 34.55 11.00 31 1338702 260 89289454
Ocular sarcoidosis 34.54 11.00 20 1338713 75 89289639
Cholestatic liver injury 34.52 11.00 7 1338726 3790 89285924
Urine leukocyte esterase positive 34.50 11.00 4 1338729 3278 89286436
Atrial tachycardia 34.50 11.00 23 1338710 5967 89283747
Bone tuberculosis 34.44 11.00 32 1338701 282 89289432
Malignant melanoma in situ 34.41 11.00 56 1338677 920 89288794
Malnutrition 34.30 11.00 149 1338584 18409 89271305
Hypoxic-ischaemic encephalopathy 34.27 11.00 13 1338720 4655 89285059
Diverticular perforation 34.18 11.00 128 1338605 3644 89286070
Intentional product use issue 34.11 11.00 3682 1335051 213210 89076504
Atrial flutter 34.05 11.00 67 1338666 10691 89279023
Hepatitis E 34.01 11.00 82 1338651 1817 89287897
Renal disorder 33.99 11.00 376 1338357 37483 89252231
Apnoea 33.98 11.00 54 1338679 9360 89280354
Radiculopathy 33.94 11.00 149 1338584 18356 89271358
Rheumatoid arthritis-associated interstitial lung disease 33.82 11.00 33 1338700 311 89289403
Cyst 33.78 11.00 384 1338349 16177 89273537
Vascular access complication 33.77 11.00 95 1338638 2318 89287396
Cushingoid 33.71 11.00 266 1338467 10129 89279585
Hypertonia 33.66 11.00 17 1338716 5138 89284576
Maternal drugs affecting foetus 33.66 11.00 17 1338716 5138 89284576
Synovial disorder 33.58 11.00 112 1338621 3006 89286708
Granulomatosis with polyangiitis 33.50 11.00 99 1338634 2486 89287228
Acute pulmonary histoplasmosis 33.45 11.00 23 1338710 124 89289590
Cutaneous vasculitis 33.39 11.00 201 1338532 6992 89282722
Anal fistula 33.36 11.00 139 1338594 4162 89285552
Normal newborn 33.34 11.00 205 1338528 23157 89266557
Tension headache 33.30 11.00 37 1338696 7472 89282242
Major depression 33.07 11.00 61 1338672 9974 89279740
BK virus infection 33.06 11.00 143 1338590 4355 89285359
Mucosal disorder 32.98 11.00 103 1338630 2668 89287046
Pain in jaw 32.96 11.00 504 1338229 47481 89242233
Inhibitory drug interaction 32.89 11.00 4 1338729 3159 89286555
Abscess 32.85 11.00 425 1338308 18466 89271248
Blood glucose fluctuation 32.83 11.00 17 1338716 5066 89284648
Traumatic lung injury 32.65 11.00 78 1338655 1718 89287996
Oral disorder 32.61 11.00 263 1338470 10082 89279632
Forced expiratory volume decreased 32.52 11.00 23 1338710 5785 89283929
Dermatitis contact 32.52 11.00 98 1338635 13497 89276217
Tumour marker increased 32.51 11.00 23 1338710 5784 89283930
Laboratory test abnormal 32.49 11.00 429 1338304 41425 89248289
Epstein-Barr viraemia 32.49 11.00 69 1338664 1401 89288313
Encephalitis 32.40 11.00 278 1338455 10856 89278858
Tendonitis 32.34 11.00 469 1338264 20903 89268811
Amylase increased 32.30 11.00 34 1338699 7038 89282676
Angioimmunoblastic T-cell lymphoma stage IV 32.30 11.00 10 1338723 0 89289714
Haemorrhagic stroke 32.26 11.00 29 1338704 6467 89283247
Mixed liver injury 32.25 11.00 39 1338694 7584 89282130
Breast cancer stage I 32.17 11.00 58 1338675 9566 89280148
Bronchopulmonary aspergillosis allergic 32.12 11.00 8 1338725 3758 89285956
Immune-mediated enterocolitis 32.11 11.00 15 1338718 4742 89284972
Brain natriuretic peptide increased 32.05 11.00 25 1338708 5980 89283734
Viral upper respiratory tract infection 31.99 11.00 228 1338505 8406 89281308
Septic arthritis staphylococcal 31.93 11.00 41 1338692 536 89289178
Screaming 31.91 11.00 8 1338725 3742 89285972
Mycobacterial infection 31.91 11.00 88 1338645 2122 89287592
Tongue neoplasm malignant stage unspecified 31.84 11.00 53 1338680 888 89288826
Cough 31.83 11.00 4873 1333860 364089 88925625
Cervix carcinoma stage 0 31.81 11.00 41 1338692 538 89289176
Long QT syndrome 31.78 11.00 10 1338723 4027 89285687
Colitis ischaemic 31.73 11.00 86 1338647 12260 89277454
Renal impairment 31.69 11.00 1254 1337479 104167 89185547
Eye pain 31.69 11.00 460 1338273 43708 89246006
Application site pain 31.68 11.00 15 1338718 4705 89285009
Lymphoedema 31.58 11.00 101 1338632 13652 89276062
Epstein-Barr virus test positive 31.47 11.00 45 1338688 656 89289058
Ataxia 31.46 11.00 148 1338585 17894 89271820
Muscular weakness 31.40 11.00 2626 1336107 204040 89085674
Pruritus genital 31.34 11.00 14 1338719 4544 89285170
Pulse absent 31.32 11.00 26 1338707 6029 89283685
Urine abnormality 31.26 11.00 41 1338692 7696 89282018
Throat clearing 31.24 11.00 9 1338724 3838 89285876
Hyperlactacidaemia 31.24 11.00 11 1338722 4125 89285589
Aplasia pure red cell 31.21 11.00 19 1338714 5175 89284539
White blood cell count increased 31.20 11.00 755 1337978 66486 89223228
Galactorrhoea 31.12 11.00 15 1338718 4657 89285057
Neoplasm malignant 31.12 11.00 687 1338046 33193 89256521
Self-injurious ideation 31.08 11.00 5 1338728 3198 89286516
Hidradenitis 31.03 11.00 137 1338596 4210 89285504
Feeling cold 30.93 11.00 258 1338475 27207 89262507
Aspiration bone marrow abnormal 30.91 11.00 15 1338718 35 89289679
Reactive gastropathy 30.87 11.00 43 1338690 611 89289103
Polycystic ovaries 30.86 11.00 23 1338710 5631 89284083
Drug specific antibody present 30.84 11.00 162 1338571 5352 89284362
Body temperature decreased 30.83 11.00 509 1338224 23307 89266407
Neoplasm recurrence 30.71 11.00 112 1338621 3147 89286567
Lower respiratory tract infection viral 30.58 11.00 53 1338680 919 89288795
Axial spondyloarthritis 30.55 11.00 42 1338691 589 89289125
Blood chloride decreased 30.44 11.00 29 1338704 6290 89283424
Leishmaniasis 30.42 11.00 18 1338715 71 89289643
Abortion induced 30.41 11.00 83 1338650 11805 89277909
Pharyngeal ulceration 30.30 11.00 54 1338679 958 89288756
Varicella 30.19 11.00 91 1338642 2311 89287403
Cystitis haemorrhagic 30.17 11.00 161 1338572 5352 89284362
Device physical property issue 30.16 11.00 3 1338730 2773 89286941
Antibody test positive 30.12 11.00 105 1338628 2884 89286830
Bundle branch block right 30.00 11.00 22 1338711 5431 89284283
Catheterisation cardiac 29.96 11.00 18 1338715 4938 89284776
Tooth infection 29.89 11.00 441 1338292 19729 89269985
Craniosynostosis 29.86 11.00 23 1338710 152 89289562
Device loosening 29.82 11.00 50 1338683 843 89288871
Epstein-Barr virus antigen positive 29.81 11.00 15 1338718 39 89289675
Encephalitis fungal 29.69 11.00 18 1338715 75 89289639
Sexual dysfunction 29.67 11.00 17 1338716 4787 89284927
Anaemia megaloblastic 29.64 11.00 36 1338697 443 89289271
Pemphigoid 29.63 11.00 55 1338678 8971 89280743
Synovial rupture 29.62 11.00 30 1338703 297 89289417
Iris adhesions 29.59 11.00 34 1338699 393 89289321
Blood phosphorus decreased 29.44 11.00 19 1338714 5015 89284699
Short stature 29.39 11.00 55 1338678 1015 89288699
Feeling jittery 29.28 11.00 122 1338611 15249 89274465
Eyelid oedema 29.15 11.00 81 1338652 11453 89278261
Varicella zoster pneumonia 29.07 11.00 20 1338713 108 89289606
Catheter site haemorrhage 29.03 11.00 9 1338724 3659 89286055
Nocturia 29.02 11.00 68 1338665 10187 89279527
Ankle arthroplasty 29.00 11.00 100 1338633 2731 89286983
Haemodialysis 28.98 11.00 53 1338680 8694 89281020
Nail psoriasis 28.98 11.00 44 1338689 679 89289035
Legionella infection 28.91 11.00 37 1338696 482 89289232
Encephalopathy 28.85 11.00 497 1338236 45947 89243767
Mood swings 28.85 11.00 183 1338550 20519 89269195
Intertrigo 28.84 11.00 47 1338686 773 89288941
Embolic stroke 28.81 11.00 12 1338721 4060 89285654
Necrotising retinitis 28.80 11.00 38 1338695 511 89289203
Inflammatory pain 28.77 11.00 54 1338679 999 89288715
Coccidioidomycosis 28.72 11.00 58 1338675 1135 89288579
JC virus infection 28.69 11.00 97 1338636 2622 89287092
Clostridium difficile infection 28.69 11.00 370 1338363 35875 89253839
Therapeutic response unexpected 28.68 11.00 197 1338536 21683 89268031
Dry mouth 28.68 11.00 2334 1336399 181725 89107989
Dysstasia 28.68 11.00 525 1338208 24527 89265187
Anaplastic large-cell lymphoma 28.65 11.00 18 1338715 81 89289633
Lupus-like syndrome 28.61 11.00 934 1337799 47912 89241802
Ventricular arrhythmia 28.59 11.00 14 1338719 4307 89285407
Nasal congestion 28.49 11.00 977 1337756 82437 89207277
Bone fissure 28.40 11.00 37 1338696 491 89289223
Large granular lymphocytosis 28.37 11.00 28 1338705 268 89289446
Hepatitis B virus test positive 28.29 11.00 25 1338708 205 89289509
Hepatitis B 28.26 11.00 137 1338596 4382 89285332
Ovarian cancer 28.23 11.00 184 1338549 6583 89283131
Bone abscess 28.21 11.00 35 1338698 441 89289273
Visual acuity reduced 28.16 11.00 216 1338517 23194 89266520
Limb operation 28.13 11.00 137 1338596 4390 89285324
Coma scale abnormal 28.08 11.00 25 1338708 5601 89284113
Immune system disorder 27.98 11.00 284 1338449 11621 89278093
Economic problem 27.92 11.00 7 1338726 3274 89286440
Chondrocalcinosis 27.92 11.00 68 1338665 1517 89288197
Choking 27.88 11.00 88 1338645 11945 89277769
Blood bicarbonate decreased 27.84 11.00 6 1338727 3113 89286601
Cardiac failure acute 27.81 11.00 87 1338646 11842 89277872
Secretion discharge 27.80 11.00 358 1338375 15538 89274176
Cytomegalovirus infection reactivation 27.76 11.00 204 1338529 7596 89282118
Squamous cell carcinoma 27.73 11.00 249 1338484 9852 89279862
Mucormycosis 27.72 11.00 121 1338612 3700 89286014
Diffuse large B-cell lymphoma stage III 27.67 11.00 14 1338719 37 89289677
Pruritus allergic 27.66 11.00 72 1338661 1676 89288038
Epidural lipomatosis 27.65 11.00 26 1338707 233 89289481
Joint dislocation 27.56 11.00 858 1337875 43724 89245990
Hypoaesthesia 27.53 11.00 4146 1334587 310064 88979650
Isosporiasis 27.47 11.00 13 1338720 28 89289686
Throat irritation 27.45 11.00 530 1338203 48165 89241549
Anaemia macrocytic 27.44 11.00 137 1338596 4435 89285279
Joint lock 27.36 11.00 92 1338641 2480 89287234
Palindromic rheumatism 27.36 11.00 23 1338710 175 89289539
Myocardial ischaemia 27.34 11.00 108 1338625 13706 89276008
Heavy menstrual bleeding 27.33 11.00 184 1338549 20346 89269368
Osteomyelitis 27.30 11.00 570 1338163 27276 89262438
Petit mal epilepsy 27.28 11.00 20 1338713 4938 89284776
Infusion site extravasation 27.26 11.00 71 1338662 10257 89279457
Multiple sclerosis 27.23 11.00 271 1338462 27569 89262145
Maternal exposure during breast feeding 27.20 11.00 31 1338702 6189 89283525
Blood pressure systolic increased 27.16 11.00 1087 1337646 57258 89232456
Upper-airway cough syndrome 27.08 11.00 123 1338610 15012 89274702
Hypoventilation 27.08 11.00 23 1338710 5273 89284441
Cervix carcinoma 27.07 11.00 110 1338623 3256 89286458
Glioma 27.06 11.00 33 1338700 408 89289306
Palmoplantar keratoderma 27.05 11.00 9 1338724 3498 89286216
Acute myeloid leukaemia 27.04 11.00 442 1338291 20198 89269516
Attention deficit hyperactivity disorder 27.02 11.00 14 1338719 4170 89285544
Pyrexia 27.02 11.00 9042 1329691 651443 88638271
Pulmonary arterial pressure increased 26.97 11.00 12 1338721 3904 89285810
Haemolysis 26.94 11.00 53 1338680 8457 89281257
Abdominal wall haematoma 26.93 11.00 8 1338725 3344 89286370
Medical device site joint infection 26.88 11.00 30 1338703 335 89289379
Hypoacusis 26.86 11.00 272 1338461 27578 89262136
Inability to afford medication 26.73 11.00 10 1338723 3612 89286102
Gout 26.71 11.00 143 1338590 16716 89272998
Pharyngitis streptococcal 26.69 11.00 297 1338436 12445 89277269
Hypophysitis 26.67 11.00 3 1338730 2517 89287197
Cross sensitivity reaction 26.54 11.00 5 1338728 2852 89286862
Nystagmus 26.52 11.00 41 1338692 7186 89282528
Skin reaction 26.46 11.00 403 1338330 18150 89271564
Prescribed overdose 26.45 11.00 1175 1337558 96450 89193264
Appetite disorder 26.30 11.00 60 1338673 9073 89280641
Peptic ulcer haemorrhage 26.29 11.00 54 1338679 1070 89288644
Metatarsalgia 26.28 11.00 32 1338701 395 89289319
Device infusion issue 26.18 11.00 4 1338729 2658 89287056
Device use issue 26.18 11.00 11 1338722 3702 89286012
Infusion site infection 26.15 11.00 4 1338729 2656 89287058
Exposure to communicable disease 26.13 11.00 40 1338693 622 89289092
Immune effector cell-associated neurotoxicity syndrome 26.05 11.00 28 1338705 5740 89283974
Catheter site infection 26.03 11.00 27 1338706 5627 89284087
Toe operation 26.02 11.00 55 1338678 1113 89288601
Infected dermal cyst 26.00 11.00 34 1338699 453 89289261
Borrelia infection 26.00 11.00 27 1338706 276 89289438
Post procedural haemorrhage 25.99 11.00 57 1338676 8741 89280973
Osteopenia 25.97 11.00 481 1338252 22521 89267193
Eye movement disorder 25.92 11.00 32 1338701 6166 89283548
Hyperthermia 25.81 11.00 73 1338660 10262 89279452
Skin weeping 25.80 11.00 5 1338728 2795 89286919
Blood thyroid stimulating hormone decreased 25.77 11.00 28 1338705 5712 89284002
Liver injury 25.77 11.00 2888 1335845 167679 89122035
Pleuropericarditis 25.71 11.00 29 1338704 328 89289386
Carcinoma in situ of skin 25.70 11.00 24 1338709 213 89289501
Laryngeal disorder 25.67 11.00 54 1338679 1089 89288625
Drug tolerance decreased 25.67 11.00 639 1338094 31491 89258223
International normalised ratio fluctuation 25.61 11.00 102 1338631 2991 89286723
Ulcerative keratitis 25.55 11.00 110 1338623 3343 89286371
Hypophagia 25.53 11.00 375 1338358 35562 89254152
Infusion site discharge 25.52 11.00 3 1338730 2432 89287282
Lung squamous cell carcinoma recurrent 25.51 11.00 10 1338723 10 89289704
Hypokinesia 25.51 11.00 132 1338601 15565 89274149
Skin burning sensation 25.49 11.00 177 1338556 19434 89270280
Keratopathy 25.47 11.00 41 1338692 667 89289047
Superior sagittal sinus thrombosis 25.42 11.00 44 1338689 762 89288952
Enterovirus test positive 25.41 11.00 22 1338711 175 89289539
Osteonecrosis of jaw 25.41 11.00 415 1338318 38688 89251026
Arteriosclerosis 25.41 11.00 79 1338654 10774 89278940
Arachnoiditis 25.40 11.00 37 1338696 549 89289165
Knee deformity 25.40 11.00 65 1338668 1497 89288217
Therapeutic product ineffective 25.37 11.00 86 1338647 2328 89287386
Snoring 25.32 11.00 23 1338710 5103 89284611
Gastrointestinal lymphoma 25.30 11.00 16 1338717 73 89289641
Catheter site pain 25.28 11.00 27 1338706 5552 89284162
Soft tissue swelling 25.22 11.00 60 1338673 1318 89288396
Tongue oedema 25.16 11.00 26 1338707 5428 89284286
Back pain 25.15 11.00 4209 1334524 312966 88976748
Ganglioneuroma 25.09 11.00 19 1338714 122 89289592
Staphylococcal abscess 24.95 11.00 44 1338689 774 89288940
Herpes zoster cutaneous disseminated 24.90 11.00 23 1338710 201 89289513
Bone density decreased 24.83 11.00 377 1338356 16968 89272746
Cardioactive drug level increased 24.83 11.00 3 1338730 2381 89287333
Gastrointestinal toxicity 24.78 11.00 231 1338502 9236 89280478
Generalised oedema 24.75 11.00 172 1338561 18881 89270833
Molluscum contagiosum 24.73 11.00 28 1338705 318 89289396
Myelodysplastic syndrome 24.61 11.00 440 1338293 20463 89269251
Frequent bowel movements 24.61 11.00 646 1338087 56289 89233425
Electrocardiogram ST segment depression 24.58 11.00 9 1338724 3294 89286420
American trypanosomiasis 24.53 11.00 24 1338709 227 89289487
Lung neoplasm malignant 24.50 11.00 499 1338234 23774 89265940
Cartilage atrophy 24.46 11.00 21 1338712 165 89289549
Occupational exposure to product 24.45 11.00 4 1338729 2527 89287187
Central nervous system vasculitis 24.45 11.00 52 1338681 1057 89288657
Failure to thrive 24.43 11.00 55 1338678 8356 89281358
Product preparation issue 24.31 11.00 3 1338730 2343 89287371
Obliterative bronchiolitis 24.31 11.00 91 1338642 2590 89287124
Tuberculosis gastrointestinal 24.29 11.00 30 1338703 376 89289338
Amenorrhoea 24.26 11.00 90 1338643 11632 89278082
Breast cancer metastatic 24.17 11.00 128 1338605 15004 89274710
Application site rash 24.10 11.00 5 1338728 2664 89287050
Intestinal fibrosis 24.05 11.00 23 1338710 211 89289503
Oropharyngeal pain 24.00 11.00 1995 1336738 113192 89176522
Prosthesis implantation 23.99 11.00 17 1338716 97 89289617
Stoma site oedema 23.99 11.00 17 1338716 97 89289617
Device issue 23.95 11.00 300 1338433 29237 89260477
Coagulopathy 23.92 11.00 224 1338509 23065 89266649
Bone marrow oedema 23.91 11.00 61 1338672 1402 89288312
Middle lobe syndrome 23.90 11.00 12 1338721 31 89289683
Double stranded DNA antibody positive 23.82 11.00 31 1338702 411 89289303
Incoherent 23.79 11.00 23 1338710 4954 89284760
Obsessive-compulsive disorder 23.72 11.00 19 1338714 4485 89285229
Dyspepsia 23.70 11.00 2563 1336170 195597 89094117
Post procedural infection 23.60 11.00 259 1338474 10815 89278899
Paradoxical psoriasis 23.58 11.00 28 1338705 336 89289378
Vitamin D deficiency 23.54 11.00 157 1338576 17399 89272315
Aphasia 23.52 11.00 468 1338265 42344 89247370
Product taste abnormal 23.51 11.00 4 1338729 2456 89287258
Hypertension 23.51 11.00 6204 1332529 451328 88838386
Stenosis 23.47 11.00 76 1338657 2008 89287706
Dysphoria 23.47 11.00 34 1338699 6120 89283594
Tubal rupture 23.46 11.00 9 1338724 8 89289706
Deafness 23.44 11.00 465 1338268 22049 89267665
Pelvic pain 23.38 11.00 132 1338601 15225 89274489
Eye infection toxoplasmal 23.37 11.00 30 1338703 392 89289322
Lung cancer metastatic 23.31 11.00 95 1338638 2816 89286898
Hepatic cirrhosis 23.18 11.00 1150 1337583 62103 89227611
T-cell lymphoma 23.15 11.00 42 1338691 756 89288958
Intervertebral disc space narrowing 23.15 11.00 51 1338682 1063 89288651
Blood sodium increased 23.13 11.00 9 1338724 3173 89286541
Psychotic symptom 23.10 11.00 3 1338730 2253 89287461
Cardiac sarcoidosis 23.08 11.00 17 1338716 104 89289610
Sudden death 23.08 11.00 83 1338650 10826 89278888
Rash papular 23.01 11.00 191 1338542 20164 89269550
Oropharyngeal cancer 22.89 11.00 12 1338721 35 89289679
Ankle operation 22.88 11.00 61 1338672 1441 89288273
Catheter site discharge 22.84 11.00 4 1338729 2405 89287309
Monoclonal gammopathy 22.83 11.00 44 1338689 831 89288883
Abdominal pain lower 22.81 11.00 311 1338422 29866 89259848
Distributive shock 22.80 11.00 11 1338722 3413 89286301
Subdural haemorrhage 22.79 11.00 11 1338722 3412 89286302
Pyomyositis 22.76 11.00 30 1338703 403 89289311
Granulomatous liver disease 22.68 11.00 46 1338687 903 89288811
Arthritis viral 22.61 11.00 7 1338726 0 89289714
Osteophyte fracture 22.61 11.00 7 1338726 0 89289714
Urine ketone body present 22.60 11.00 5 1338728 2547 89287167
Refusal of treatment by patient 22.58 11.00 31 1338702 5707 89284007
Respiratory tract congestion 22.45 11.00 547 1338186 26863 89262851
Diffuse large B-cell lymphoma stage II 22.45 11.00 14 1338719 62 89289652
Lip and/or oral cavity cancer 22.40 11.00 45 1338688 877 89288837
Squamous cell carcinoma of the cervix 22.31 11.00 29 1338704 384 89289330
Cardiomyopathy 22.22 11.00 191 1338542 20015 89269699
Infusion site mass 22.20 11.00 3 1338730 2186 89287528
Ear pain 22.18 11.00 1054 1337679 56648 89233066
Blood albumin decreased 22.17 11.00 151 1338582 16652 89273062
Brain injury 22.15 11.00 51 1338682 7687 89282027
Anosmia 22.14 11.00 73 1338660 9775 89279939
Sensory disturbance 22.12 11.00 135 1338598 15278 89274436
Mycotic allergy 22.06 11.00 49 1338684 1027 89288687
Hair follicle tumour benign 22.03 11.00 29 1338704 389 89289325
Polyhydramnios 22.03 11.00 5 1338728 2503 89287211
Red cell distribution width decreased 22.00 11.00 77 1338656 2119 89287595
Language disorder 21.92 11.00 6 1338727 2646 89287068
Nodal osteoarthritis 21.92 11.00 47 1338686 961 89288753
Chronic recurrent multifocal osteomyelitis 21.83 11.00 13 1338720 52 89289662
Anticipatory anxiety 21.83 11.00 53 1338680 1180 89288534
Ejection fraction abnormal 21.82 11.00 5 1338728 2486 89287228
Blood phosphorus increased 21.78 11.00 19 1338714 4299 89285415
Laryngospasm 21.75 11.00 11 1338722 3322 89286392
Abdominal pain upper 21.74 11.00 4460 1334273 328214 88961500
Infusion site rash 21.72 11.00 5 1338728 2478 89287236
Emotional disorder 21.71 11.00 131 1338602 14866 89274848
Blood triglycerides increased 21.65 11.00 117 1338616 13644 89276070
Prosthesis user 21.63 11.00 14 1338719 67 89289647
Enteral nutrition 21.63 11.00 22 1338711 219 89289495
Granulomatous dermatitis 21.60 11.00 21 1338712 197 89289517
Herpes zoster infection neurological 21.52 11.00 33 1338700 514 89289200
Decreased interest 21.50 11.00 20 1338713 4387 89285327
Small intestinal obstruction 21.48 11.00 205 1338528 21029 89268685
Cerebral haematoma 21.47 11.00 19 1338714 4270 89285444
Implant site pain 21.42 11.00 6 1338727 2606 89287108
Malignant peritoneal neoplasm 21.38 11.00 40 1338693 738 89288976
Type I hypersensitivity 21.30 11.00 18 1338715 4137 89285577
Oesophagitis 21.30 11.00 158 1338575 17091 89272623
Total lung capacity decreased 21.28 11.00 15 1338718 3780 89285934
Intestinal anastomosis 21.22 11.00 44 1338689 878 89288836
Enuresis 21.20 11.00 12 1338721 3402 89286312
Endometrial adenocarcinoma 21.20 11.00 58 1338675 1392 89288322
Mean platelet volume decreased 21.08 11.00 93 1338640 2857 89286857
Linear IgA disease 21.08 11.00 4 1338729 2270 89287444
Electrocardiogram ST segment elevation 21.08 11.00 17 1338716 3999 89285715
Anxiety disorder 21.02 11.00 25 1338708 4897 89284817
Nodular melanoma 21.02 11.00 14 1338719 71 89289643
Genital abscess 20.99 11.00 25 1338708 301 89289413
Carbohydrate antigen 125 increased 20.98 11.00 11 1338722 3255 89286459
Septic shock 20.92 11.00 1478 1337255 82682 89207032
Vulval cancer metastatic 20.91 11.00 8 1338725 7 89289707
Blood glucose abnormal 20.90 11.00 71 1338662 9421 89280293
Central nervous system leukaemia 20.88 11.00 22 1338711 229 89289485
Acquired claw toe 20.87 11.00 20 1338713 184 89289530
Hypoglycaemic coma 20.85 11.00 9 1338724 2981 89286733
Extrasystoles 20.85 11.00 32 1338701 5625 89284089
Incorrect drug administration rate 20.77 11.00 28 1338705 5195 89284519
Torticollis 20.75 11.00 6 1338727 2552 89287162
Plasmablastic lymphoma 20.74 11.00 22 1338711 231 89289483
Bone density abnormal 20.72 11.00 118 1338615 4022 89285692
Meningitis coccidioides 20.70 11.00 10 1338723 23 89289691
Sarcoidosis 20.66 11.00 245 1338488 10428 89279286
Diabetes mellitus 20.66 11.00 1164 1337569 63711 89226003
Blood pressure abnormal 20.58 11.00 188 1338545 19457 89270257
Ammonia increased 20.58 11.00 26 1338707 4960 89284754
Pneumonia viral 20.51 11.00 210 1338523 8613 89281101
Sputum increased 20.46 11.00 9 1338724 2948 89286766
Quadriplegia 20.46 11.00 76 1338657 2155 89287559
Gastrointestinal inflammation 20.44 11.00 169 1338564 6527 89283187
Lip oedema 20.42 11.00 23 1338710 4616 89285098
Mass excision 20.41 11.00 26 1338707 337 89289377
Cardiac pacemaker insertion 20.34 11.00 21 1338712 4386 89285328
Birdshot chorioretinopathy 20.29 11.00 14 1338719 76 89289638
Physical disability 20.27 11.00 114 1338619 3867 89285847
Nerve injury 20.22 11.00 252 1338481 10854 89278860
Rheumatoid factor 20.20 11.00 31 1338702 483 89289231
Apathy 20.18 11.00 89 1338644 10951 89278763
Brain oedema 20.17 11.00 162 1338571 17223 89272491
Arteriospasm coronary 20.16 11.00 27 1338706 5023 89284691
Viral haemorrhagic cystitis 20.14 11.00 58 1338675 1435 89288279
Flank pain 20.12 11.00 184 1338549 19038 89270676
Viral vasculitis 20.09 11.00 15 1338718 94 89289620
Anal stenosis 20.08 11.00 32 1338701 516 89289198
Haemodynamic instability 20.06 11.00 97 1338636 11642 89278072
Torus fracture 20.06 11.00 18 1338715 151 89289563
Multiple allergies 20.04 11.00 136 1338597 15010 89274704
Skin tightness 20.03 11.00 22 1338711 4466 89285248
Listeriosis 20.02 11.00 64 1338669 1679 89288035
Drug level increased 19.96 11.00 289 1338444 27473 89262241
Premature rupture of membranes 19.95 11.00 32 1338701 5526 89284188
Abscess sweat gland 19.94 11.00 8 1338725 9 89289705
Keratitis 19.93 11.00 114 1338619 3892 89285822
Bruxism 19.90 11.00 21 1338712 4342 89285372
Blood creatine increased 19.87 11.00 46 1338687 6921 89282793
Vaginal cancer 19.84 11.00 24 1338709 294 89289420
Hypergammaglobulinaemia benign monoclonal 19.82 11.00 44 1338689 922 89288792
Hypermobility syndrome 19.80 11.00 42 1338691 852 89288862
Tender joint count increased 19.76 11.00 21 1338712 221 89289493
Perineal infection 19.72 11.00 19 1338714 176 89289538
Pseudopolyp 19.72 11.00 27 1338706 377 89289337
Disseminated varicella zoster virus infection 19.69 11.00 29 1338704 435 89289279
Tearfulness 19.65 11.00 25 1338708 4755 89284959
Breast abscess 19.65 11.00 72 1338661 2028 89287686
Subdural abscess 19.61 11.00 10 1338723 27 89289687
Guttate psoriasis 19.61 11.00 33 1338700 558 89289156
Nephrogenic anaemia 19.61 11.00 6 1338727 2460 89287254
Invasive ductal breast carcinoma 19.59 11.00 189 1338544 7629 89282085
Muscle spasticity 19.57 11.00 671 1338062 34651 89255063
Infiltration anaesthesia 19.56 11.00 19 1338714 178 89289536
Bradyarrhythmia 19.54 11.00 6 1338727 2455 89287259
Meningitis haemophilus 19.50 11.00 7 1338726 4 89289710
Pneumocystis jirovecii infection 19.50 11.00 68 1338665 1868 89287846
Biliary dyskinesia 19.48 11.00 7 1338726 2592 89287122
Internal haemorrhage 19.46 11.00 39 1338694 6181 89283533
Histiocytic necrotising lymphadenitis 19.45 11.00 11 1338722 39 89289675
Malignant neoplasm of conjunctiva 19.45 11.00 11 1338722 39 89289675
Essential hypertension 19.41 11.00 40 1338693 6275 89283439
Respiratory tract ulceration 19.38 11.00 6 1338727 0 89289714
Hepatic steato-fibrosis 19.38 11.00 6 1338727 0 89289714
Oropharyngeal discolouration 19.38 11.00 6 1338727 0 89289714
Logorrhoea 19.35 11.00 8 1338725 2719 89286995
Bedridden 19.35 11.00 269 1338464 11879 89277835
Menstruation irregular 19.35 11.00 58 1338675 8002 89281712
Hip surgery 19.33 11.00 117 1338616 4078 89285636
Poor quality device used 19.31 11.00 5 1338728 2288 89287426
Protein total decreased 19.28 11.00 48 1338685 7041 89282673
Salivary gland cancer 19.24 11.00 19 1338714 182 89289532
Body temperature increased 19.22 11.00 826 1337907 43884 89245830
IgA nephropathy 19.20 11.00 42 1338691 871 89288843
Injection site haematoma 19.19 11.00 171 1338562 6751 89282963
Multiple fractures 19.18 11.00 221 1338512 9341 89280373
Application site irritation 19.17 11.00 3 1338730 1958 89287756
Hypocomplementaemia 19.16 11.00 22 1338711 254 89289460
Wernicke's encephalopathy 19.13 11.00 9 1338724 19 89289695
Lung squamous cell carcinoma stage I 19.08 11.00 8 1338725 11 89289703
Skin irritation 19.08 11.00 120 1338613 13483 89276231
Product dose omission in error 19.05 11.00 202 1338531 20301 89269413
Diffuse alopecia 19.05 11.00 50 1338683 1170 89288544
Meningoencephalitis herpetic 19.03 11.00 56 1338677 1403 89288311
Abscess limb 19.03 11.00 152 1338581 5810 89283904
Bone marrow disorder 19.02 11.00 92 1338641 2940 89286774
Pleural fibrosis 18.99 11.00 104 1338629 3492 89286222
Eosinophil count decreased 18.95 11.00 12 1338721 3200 89286514
Ventricular hypokinesia 18.94 11.00 31 1338702 5310 89284404
Therapy cessation 18.93 11.00 401 1338332 35960 89253754
Disease susceptibility 18.91 11.00 22 1338711 258 89289456
Acute pulmonary oedema 18.90 11.00 75 1338658 9505 89280209
Infusion site bruising 18.89 11.00 22 1338711 4350 89285364
Electrocardiogram T wave abnormal 18.89 11.00 8 1338725 2680 89287034
Limb fracture 18.88 11.00 10 1338723 30 89289684
Clostridium difficile colitis 18.86 11.00 279 1338454 26427 89263287
Steatohepatitis 18.85 11.00 39 1338694 777 89288937
Thrombosis in device 18.82 11.00 11 1338722 3064 89286650
Incorrect dosage administered 18.82 11.00 88 1338645 2772 89286942
Joint tuberculosis 18.82 11.00 17 1338716 144 89289570
Blood cholesterol decreased 18.77 11.00 3 1338730 1928 89287786
Cryptococcosis 18.75 11.00 56 1338677 1415 89288299
Dyspnoea at rest 18.74 11.00 26 1338707 4765 89284949
Perineal necrosis 18.61 11.00 16 1338717 126 89289588
Marginal zone lymphoma 18.59 11.00 14 1338719 89 89289625
Bipolar disorder 18.59 11.00 69 1338664 8916 89280798
Urticarial vasculitis 18.58 11.00 45 1338688 1000 89288714
Chondropathy 18.57 11.00 80 1338653 2432 89287282
Device malfunction 18.56 11.00 209 1338524 20768 89268946
Disseminated sporotrichosis 18.54 11.00 9 1338724 21 89289693
Haemorrhoids 18.49 11.00 280 1338453 26422 89263292
Cubital tunnel syndrome 18.47 11.00 23 1338710 291 89289423
Humoral immune defect 18.43 11.00 26 1338707 374 89289340
Morphoea 18.42 11.00 27 1338706 403 89289311
Pelvic floor muscle weakness 18.37 11.00 13 1338720 74 89289640
Respiratory rate decreased 18.36 11.00 19 1338714 3964 89285750
Stupor 18.36 11.00 33 1338700 5449 89284265
Neck mass 18.35 11.00 109 1338624 3773 89285941
Meningitis tuberculous 18.30 11.00 34 1338699 624 89289090
Hepatitis cholestatic 18.20 11.00 65 1338668 8496 89281218
Disorganised speech 18.16 11.00 3 1338730 1882 89287832
Chemotherapeutic drug level above therapeutic 18.14 11.00 12 1338721 60 89289654
Periprosthetic fracture 18.14 11.00 32 1338701 563 89289151
Steroid dependence 18.13 11.00 74 1338659 2195 89287519
Bronchial secretion retention 18.12 11.00 16 1338717 3599 89286115
Soft tissue disorder 18.11 11.00 117 1338616 4173 89285541
Sluggishness 18.10 11.00 38 1338695 5921 89283793
Crying 18.08 11.00 268 1338465 25377 89264337
Hair colour changes 18.08 11.00 15 1338718 3479 89286235
Intervertebral disc degeneration 18.06 11.00 357 1338376 16917 89272797
Injection site inflammation 18.06 11.00 122 1338611 4419 89285295
Cerebral infarction 18.04 11.00 280 1338453 26316 89263398
Immune thrombocytopenia 17.96 11.00 119 1338614 13207 89276507
Erythrodermic psoriasis 17.96 11.00 46 1338687 1060 89288654
Gardnerella test positive 17.95 11.00 8 1338725 14 89289700
Expired product administered 17.95 11.00 48 1338685 6874 89282840
Micturition urgency 17.95 11.00 95 1338638 11138 89278576
Human bocavirus infection 17.90 11.00 28 1338705 444 89289270
Arthritis enteropathic 17.89 11.00 26 1338707 385 89289329
Hyperuricaemia 17.88 11.00 46 1338687 6673 89283041
Product administered at inappropriate site 17.82 11.00 21 1338712 4130 89285584
Genital ulceration 17.81 11.00 45 1338688 1028 89288686
Bone cyst 17.78 11.00 76 1338657 2302 89287412
Diarrhoea haemorrhagic 17.75 11.00 238 1338495 10425 89279289
Electrocardiogram T wave inversion 17.63 11.00 17 1338716 3666 89286048
Facial pain 17.62 11.00 118 1338615 13064 89276650
Laryngitis fungal 17.56 11.00 18 1338715 181 89289533
Haemolytic anaemia 17.56 11.00 101 1338632 11596 89278118
Diabetic retinopathy 17.51 11.00 9 1338724 2693 89287021
Mononeuritis 17.48 11.00 9 1338724 25 89289689
Nasopharyngeal cancer 17.48 11.00 9 1338724 25 89289689
Pulmonary granuloma 17.47 11.00 59 1338674 1594 89288120
Sinus arrest 17.47 11.00 5 1338728 2141 89287573
Colorectal cancer 17.47 11.00 19 1338714 3874 89285840
Pharyngeal abscess 17.46 11.00 26 1338707 394 89289320
Fistula 17.40 11.00 263 1338470 11826 89277888
Postoperative wound infection 17.40 11.00 287 1338446 13139 89276575
Cytopenia 17.37 11.00 358 1338375 17091 89272623
Catheter site swelling 17.37 11.00 3 1338730 1822 89287892
Affective disorder 17.36 11.00 58 1338675 7735 89281979
Vasoplegia syndrome 17.32 11.00 10 1338723 2804 89286910
Gestational hypertension 17.31 11.00 12 1338721 3050 89286664
Thyroid cancer 17.30 11.00 155 1338578 6129 89283585
Supraventricular extrasystoles 17.29 11.00 32 1338701 5225 89284489
Electroencephalogram abnormal 17.28 11.00 21 1338712 4075 89285639
Myeloid leukaemia 17.25 11.00 29 1338704 490 89289224
Subclavian artery occlusion 17.23 11.00 9 1338724 26 89289688
Haemoperitoneum 17.22 11.00 16 1338717 3512 89286202
Swollen joint count increased 17.21 11.00 1886 1336847 109320 89180394
Carotid artery occlusion 17.20 11.00 43 1338690 6299 89283415
Stoma closure 17.19 11.00 18 1338715 186 89289528
Medial tibial stress syndrome 17.17 11.00 15 1338718 121 89289593
Cardiac failure chronic 17.16 11.00 36 1338697 5610 89284104
Aortic stenosis 17.15 11.00 43 1338690 6293 89283421
Lymphadenopathy 17.14 11.00 834 1337899 44941 89244773
Hydronephrosis 17.09 11.00 110 1338623 12292 89277422
Skin discolouration 17.06 11.00 511 1338222 43804 89245910
Lichen myxoedematosus 16.99 11.00 9 1338724 27 89289687
Malignant neoplasm of ampulla of Vater 16.99 11.00 9 1338724 27 89289687
Pulmonary function test decreased 16.97 11.00 25 1338708 4469 89285245
Aplasia 16.95 11.00 109 1338624 3882 89285832
Temperature intolerance 16.94 11.00 106 1338627 11924 89277790
Atelectasis 16.89 11.00 256 1338477 24153 89265561
Sinus node dysfunction 16.88 11.00 34 1338699 5378 89284336
Mixed connective tissue disease 16.86 11.00 31 1338702 564 89289150
Cutaneous sarcoidosis 16.83 11.00 27 1338706 438 89289276
Enterovirus infection 16.82 11.00 54 1338679 1420 89288294
Drug-device interaction 16.81 11.00 14 1338719 105 89289609
Meniscus injury 16.80 11.00 191 1338542 8046 89281668
Rectal cancer 16.79 11.00 73 1338660 2228 89287486
Physical deconditioning 16.78 11.00 6 1338727 2229 89287485
Bile duct cancer 16.74 11.00 33 1338700 634 89289080
Myelitis transverse 16.73 11.00 55 1338678 1465 89288249
Bladder disorder 16.72 11.00 92 1338641 10680 89279034
DNA antibody positive 16.68 11.00 24 1338709 352 89289362
Cutaneous sporotrichosis 16.68 11.00 8 1338725 18 89289696
Hemianopia 16.67 11.00 5 1338728 2077 89287637
Premature separation of placenta 16.65 11.00 7 1338726 2355 89287359
Subcutaneous abscess 16.63 11.00 161 1338572 6505 89283209
Transplant dysfunction 16.63 11.00 33 1338700 5249 89284465
Papulopustular rosacea 16.61 11.00 10 1338723 41 89289673
Neutrophilia 16.60 11.00 38 1338695 5740 89283974
Neutrophil count abnormal 16.55 11.00 22 1338711 4106 89285608
Matrix metalloproteinase-3 increased 16.55 11.00 7 1338726 10 89289704
Eczema infected 16.54 11.00 16 1338717 149 89289565
Immunisation 16.52 11.00 6 1338727 2207 89287507
Polydipsia 16.51 11.00 23 1338710 4208 89285506
Anal fissure 16.49 11.00 136 1338597 5249 89284465
Inadequate analgesia 16.48 11.00 14 1338719 3210 89286504
Acute interstitial pneumonitis 16.46 11.00 37 1338696 782 89288932
Anal ulcer 16.46 11.00 37 1338696 782 89288932
Bladder neoplasm 16.44 11.00 34 1338699 677 89289037
Intervertebral disc compression 16.44 11.00 48 1338685 1197 89288517
Poor venous access 16.39 11.00 391 1338342 19136 89270578
Blau syndrome 16.39 11.00 8 1338725 19 89289695
Low turnover osteopathy 16.39 11.00 23 1338710 4195 89285519
Rib fracture 16.38 11.00 283 1338450 26152 89263562
Gastroenteritis norovirus 16.30 11.00 74 1338659 2302 89287412
Extremity contracture 16.27 11.00 49 1338684 1244 89288470
Antithrombin III decreased 16.25 11.00 19 1338714 224 89289490
Vaccination failure 16.24 11.00 47 1338686 1166 89288548
N-terminal prohormone brain natriuretic peptide increased 16.23 11.00 12 1338721 2950 89286764
Coronary arterial stent insertion 16.23 11.00 11 1338722 2829 89286885
Mucositis management 16.15 11.00 5 1338728 0 89289714
Product container issue 16.13 11.00 6 1338727 2175 89287539
Genital infection 16.13 11.00 17 1338716 177 89289537
Purpura 16.11 11.00 140 1338593 14638 89275076
Brachiocephalic artery stenosis 16.10 11.00 9 1338724 31 89289683
Pharyngeal inflammation 16.10 11.00 43 1338690 1017 89288697
Apoptotic colonopathy 16.09 11.00 12 1338721 75 89289639
Foreign body sensation in eyes 16.07 11.00 15 1338718 3285 89286429
Erythema induratum 16.06 11.00 17 1338716 178 89289536
Empyema 16.05 11.00 72 1338661 2228 89287486
Weight bearing difficulty 16.04 11.00 84 1338649 2772 89286942
Infusion site nodule 16.04 11.00 3 1338730 1720 89287994
Dyshidrotic eczema 15.99 11.00 35 1338698 726 89288988
Live birth 15.94 11.00 981 1337752 78126 89211588
Secondary immunodeficiency 15.94 11.00 68 1338665 2058 89287656
Herpes zoster meningitis 15.92 11.00 14 1338719 114 89289600
Anovulatory cycle 15.91 11.00 16 1338717 157 89289557
Fracture 15.88 11.00 433 1338300 21643 89268071
Blood pH decreased 15.87 11.00 9 1338724 2549 89287165
Sputum discoloured 15.83 11.00 209 1338524 20182 89269532
Orthopnoea 15.83 11.00 50 1338683 6785 89282929
Wrong schedule 15.82 11.00 24 1338709 370 89289344
Non-small cell lung cancer stage II 15.82 11.00 6 1338727 5 89289709
Tachyphrenia 15.82 11.00 3 1338730 1703 89288011
Lymphoplasmacytoid lymphoma/immunocytoma 15.82 11.00 6 1338727 5 89289709
Pseudomonas test positive 15.82 11.00 39 1338694 877 89288837
Ectrodactyly 15.80 11.00 7 1338726 12 89289702
Rash pruritic 15.79 11.00 1024 1337709 81190 89208524
Venoocclusive disease 15.76 11.00 75 1338658 2380 89287334
Communication disorder 15.72 11.00 15 1338718 3251 89286463
Mucocutaneous rash 15.69 11.00 9 1338724 33 89289681
Central nervous system lesion 15.69 11.00 104 1338629 11542 89278172
Central venous catheterisation 15.64 11.00 11 1338722 2775 89286939
Segmented hyalinising vasculitis 15.63 11.00 11 1338722 62 89289652
Medical device discomfort 15.59 11.00 6 1338727 2130 89287584
Colitis ulcerative 15.58 11.00 729 1338004 59537 89230177
Anion gap increased 15.57 11.00 7 1338726 2263 89287451
Leukoerythroblastosis 15.56 11.00 21 1338712 289 89289425
Head discomfort 15.55 11.00 160 1338573 16173 89273541
Injection site urticaria 15.53 11.00 362 1338371 17649 89272065
Stoma site discharge 15.53 11.00 5 1338728 1984 89287730
Gastrointestinal sounds abnormal 15.53 11.00 27 1338706 4516 89285198
West Nile viral infection 15.47 11.00 28 1338705 503 89289211
Productive cough 15.47 11.00 956 1337777 76107 89213607
Neoscytalidium infection 15.45 11.00 7 1338726 13 89289701
Sternal fracture 15.43 11.00 12 1338721 2875 89286839
Cytomegalovirus enteritis 15.42 11.00 23 1338710 349 89289365
Injection site rash 15.41 11.00 467 1338266 23706 89266008
Terminal ileitis 15.38 11.00 47 1338686 1203 89288511
Diastolic dysfunction 15.38 11.00 56 1338677 7277 89282437
Chest X-ray abnormal 15.37 11.00 128 1338605 4954 89284760
Breath sounds abnormal 15.37 11.00 149 1338584 15237 89274477
Hepatic failure 15.32 11.00 458 1338275 39270 89250444
Blood potassium abnormal 15.31 11.00 13 1338720 2981 89286733
Gallbladder necrosis 15.31 11.00 6 1338727 6 89289708
Metastases to reproductive organ 15.31 11.00 6 1338727 6 89289708
Psoriasis area severity index decreased 15.31 11.00 6 1338727 6 89289708
Tendon graft 15.31 11.00 6 1338727 6 89289708
Breast scan 15.31 11.00 6 1338727 6 89289708
Bursitis infective staphylococcal 15.30 11.00 9 1338724 35 89289679
Haemorrhoidal haemorrhage 15.30 11.00 35 1338698 5288 89284426
Photopsia 15.30 11.00 32 1338701 4992 89284722
Food craving 15.26 11.00 5 1338728 1962 89287752
Pleural thickening 15.23 11.00 91 1338642 3157 89286557
Chronic graft versus host disease in liver 15.22 11.00 22 1338711 324 89289390
Infusion site discomfort 15.21 11.00 4 1338729 1812 89287902
Euphoric mood 15.20 11.00 36 1338697 5373 89284341
Shock haemorrhagic 15.20 11.00 112 1338621 12133 89277581
Decubitus ulcer 15.17 11.00 107 1338626 11706 89278008
Freezing phenomenon 15.16 11.00 4 1338729 1808 89287906
Abscess bacterial 15.16 11.00 19 1338714 242 89289472
Follicle centre lymphoma, follicular grade I, II, III 15.16 11.00 12 1338721 83 89289631
Metastatic bronchial carcinoma 15.16 11.00 17 1338716 191 89289523
Right ventricular dysfunction 15.13 11.00 8 1338725 2356 89287358
Leukodystrophy 15.12 11.00 9 1338724 36 89289678
Periorbital swelling 15.08 11.00 30 1338703 4768 89284946
Enthesophyte 15.08 11.00 15 1338718 145 89289569
Pachymeningitis 15.04 11.00 19 1338714 244 89289470
Staphylococcal sepsis 15.04 11.00 208 1338525 9175 89280539
Alcoholism 15.01 11.00 4 1338729 1796 89287918
Extravasation 15.00 11.00 13 1338720 2951 89286763
Chronic graft versus host disease oral 14.97 11.00 18 1338715 219 89289495
Fanconi syndrome 14.96 11.00 5 1338728 1938 89287776
Iridocyclitis 14.94 11.00 99 1338634 3562 89286152
Immunosuppressant drug level increased 14.94 11.00 29 1338704 4651 89285063
Social avoidant behaviour 14.94 11.00 17 1338716 3396 89286318
Skin bacterial infection 14.90 11.00 31 1338702 620 89289094
Madarosis 14.90 11.00 19 1338714 3610 89286104
Neck deformity 14.88 11.00 68 1338665 2121 89287593
Crystal nephropathy 14.84 11.00 44 1338689 1107 89288607
Neovascularisation 14.83 11.00 3 1338730 1627 89288087
Musculoskeletal chest pain 14.80 11.00 254 1338479 23496 89266218
Middle insomnia 14.78 11.00 167 1338566 16584 89273130
Loose body in joint 14.78 11.00 50 1338683 1352 89288362
Erythema of eyelid 14.75 11.00 16 1338717 3267 89286447
Feeling drunk 14.74 11.00 30 1338703 4728 89284986
White blood cells urine positive 14.72 11.00 48 1338685 6450 89283264
Scleroderma renal crisis 14.68 11.00 25 1338708 427 89289287
Ocular toxicity 14.68 11.00 42 1338691 1035 89288679
Polyarteritis nodosa 14.64 11.00 21 1338712 307 89289407
Product monitoring error 14.64 11.00 28 1338705 4516 89285198
Cardiovascular disorder 14.63 11.00 128 1338605 13364 89276350
Muscle contractions involuntary 14.63 11.00 13 1338720 2915 89286799
Chronic graft versus host disease in intestine 14.62 11.00 15 1338718 151 89289563
Vasculitic rash 14.61 11.00 50 1338683 1360 89288354
Oesophageal squamous cell carcinoma 14.59 11.00 14 1338719 129 89289585
Tic 14.57 11.00 5 1338728 1906 89287808
Blood urine present 14.57 11.00 174 1338559 17104 89272610
Perirectal abscess 14.56 11.00 39 1338694 924 89288790
Elbow operation 14.55 11.00 24 1338709 399 89289315
Root canal infection 14.55 11.00 24 1338709 399 89289315
Embryonal rhabdomyosarcoma 14.52 11.00 7 1338726 16 89289698
Splenic infection 14.52 11.00 7 1338726 16 89289698
Streptococcal infection 14.49 11.00 169 1338564 7164 89282550
Spinal meningioma benign 14.49 11.00 13 1338720 109 89289605
Tendon pain 14.49 11.00 100 1338633 3648 89286066
Corneal oedema 14.45 11.00 5 1338728 1896 89287818
Vulvovaginal erythema 14.41 11.00 29 1338704 566 89289148
Haematocolpos 14.39 11.00 10 1338723 55 89289659
Tachyarrhythmia 14.39 11.00 37 1338696 5369 89284345
Product prescribing error 14.39 11.00 337 1338396 29808 89259906
Idiopathic interstitial pneumonia 14.37 11.00 19 1338714 256 89289458
Herpes zoster oticus 14.37 11.00 26 1338707 467 89289247
Hypertensive cardiomyopathy 14.37 11.00 20 1338713 284 89289430
Dermatitis acneiform 14.35 11.00 47 1338686 6307 89283407
Abnormal weight gain 14.34 11.00 11 1338722 2654 89287060
Hypovolaemic shock 14.34 11.00 55 1338678 7039 89282675
Ileal perforation 14.33 11.00 27 1338706 501 89289213
Neurosarcoidosis 14.30 11.00 21 1338712 314 89289400
Pterygium 14.26 11.00 21 1338712 315 89289399
Retinal injury 14.25 11.00 23 1338710 375 89289339
Wound infection pseudomonas 14.25 11.00 6 1338727 2017 89287697
Tubular breast carcinoma 14.24 11.00 9 1338724 41 89289673
Anticoagulation drug level above therapeutic 14.24 11.00 6 1338727 2016 89287698
Erythema migrans 14.22 11.00 8 1338725 28 89289686
Strongyloidiasis 14.22 11.00 54 1338679 1548 89288166
Anticonvulsant drug level increased 14.21 11.00 4 1338729 1732 89287982
Akinesia 14.21 11.00 4 1338729 1732 89287982
Depressive symptom 14.20 11.00 36 1338697 5249 89284465
Conduction disorder 14.20 11.00 4 1338729 1731 89287983
High density lipoprotein decreased 14.19 11.00 11 1338722 2640 89287074
Skin mass 14.14 11.00 170 1338563 7260 89282454
Fixed eruption 14.14 11.00 4 1338729 1726 89287988
Mucocutaneous leishmaniasis 14.13 11.00 23 1338710 378 89289336
Product odour abnormal 14.07 11.00 3 1338730 1568 89288146
Carbohydrate antigen 15-3 increased 14.06 11.00 6 1338727 2001 89287713
Duodenal ulcer 14.06 11.00 83 1338650 9469 89280245
Psychomotor skills impaired 14.05 11.00 13 1338720 2859 89286855
Intestinal tuberculosis 14.04 11.00 13 1338720 114 89289600
Vulval cancer 14.03 11.00 35 1338698 793 89288921
Helicobacter gastritis 14.03 11.00 56 1338677 1644 89288070
Burning sensation 14.01 11.00 780 1337953 62672 89227042
Paranasal sinus discomfort 13.98 11.00 46 1338687 6164 89283550
Alcohol use 13.98 11.00 4 1338729 1713 89288001
Accident at work 13.97 11.00 27 1338706 511 89289203
Thyroiditis 13.96 11.00 20 1338713 3617 89286097
Product availability issue 13.96 11.00 59 1338674 7345 89282369
COVID-19 13.87 11.00 2236 1336497 166607 89123107
T-cell lymphoma refractory 13.86 11.00 10 1338723 59 89289655
Herpes gestationis 13.84 11.00 5 1338728 3 89289711
Haematoma muscle 13.84 11.00 5 1338728 1845 89287869
Bowen's disease 13.83 11.00 17 1338716 212 89289502
Spinal disorder 13.81 11.00 246 1338487 11433 89278281
Hypersensitivity vasculitis 13.80 11.00 107 1338626 4052 89285662
Coordination abnormal 13.76 11.00 227 1338506 21129 89268585
Nephrectomy 13.76 11.00 6 1338727 1975 89287739
Right ventricular dilatation 13.75 11.00 4 1338729 1695 89288019
Cutaneous lymphoma 13.68 11.00 15 1338718 164 89289550
Drug eruption 13.66 11.00 647 1338086 34760 89254954
Non-cardiac chest pain 13.65 11.00 52 1338681 6669 89283045
Chloroma 13.65 11.00 18 1338715 242 89289472
Coagulation time prolonged 13.64 11.00 4 1338729 1686 89288028
Spinal osteoarthritis 13.61 11.00 375 1338358 18773 89270941
Parakeratosis 13.60 11.00 21 1338712 329 89289385
Granulomatous lymphadenitis 13.60 11.00 17 1338716 216 89289498
Carpal tunnel decompression 13.58 11.00 41 1338692 1042 89288672
Sacroiliac joint dysfunction 13.57 11.00 11 1338722 79 89289635
Ankle brachial index decreased 13.57 11.00 11 1338722 79 89289635
Renal tubular injury 13.57 11.00 45 1338688 1204 89288510
Loss of employment 13.57 11.00 83 1338650 2904 89286810
Therapy partial responder 13.56 11.00 424 1338309 21619 89268095
Graft versus host disease in lung 13.55 11.00 27 1338706 523 89289191
Lower respiratory tract inflammation 13.53 11.00 13 1338720 120 89289594
Stenotrophomonas bacteraemia 13.53 11.00 13 1338720 120 89289594
Acute lymphocytic leukaemia 13.49 11.00 80 1338653 2768 89286946
Laryngeal stenosis 13.46 11.00 47 1338686 1292 89288422
Retroperitoneal haematoma 13.45 11.00 18 1338715 3350 89286364
Exposed bone in jaw 13.44 11.00 14 1338719 2912 89286802
Blood cholesterol increased 13.43 11.00 3364 1335369 204648 89085066
Idiopathic pneumonia syndrome 13.42 11.00 24 1338709 427 89289287
Salpingo-oophoritis 13.42 11.00 14 1338719 144 89289570
Scarlet fever 13.42 11.00 14 1338719 144 89289570
Pneumonia 13.39 11.00 8929 1329804 629130 88660584
Application site vesicles 13.38 11.00 3 1338730 1514 89288200
Pulmonary thrombosis 13.36 11.00 87 1338646 9695 89280019
Hereditary motor and sensory neuropathy 13.34 11.00 12 1338721 101 89289613
Stress at work 13.31 11.00 48 1338685 1341 89288373
Hepatitis acute 13.31 11.00 100 1338633 10787 89278927
Hepatic cytolysis 13.30 11.00 351 1338382 30565 89259149
Kidney infection 13.29 11.00 488 1338245 25428 89264286
Leptospirosis 13.27 11.00 5 1338728 4 89289710
Vagus nerve paralysis 13.27 11.00 5 1338728 4 89289710
Self-consciousness 13.23 11.00 10 1338723 64 89289650
Slow speech 13.19 11.00 6 1338727 1927 89287787
Metabolic disorder 13.19 11.00 61 1338672 7409 89282305
Heart rate decreased 13.18 11.00 939 1337794 52566 89237148
Hepatic function abnormal 13.18 11.00 554 1338179 45734 89243980
Genital cyst 13.17 11.00 9 1338724 48 89289666
Anal cancer 13.14 11.00 28 1338705 570 89289144
Aortic aneurysm 13.13 11.00 110 1338623 4265 89285449
Q fever 13.12 11.00 14 1338719 148 89289566
Adverse event 13.12 11.00 1952 1336781 115466 89174248
Stoma site erythema 13.11 11.00 3 1338730 1493 89288221
Eye discharge 13.11 11.00 70 1338663 8188 89281526
Dengue fever 13.11 11.00 36 1338697 866 89288848
Encephalitis viral 13.08 11.00 59 1338674 1830 89287884
Quadrantanopia 13.08 11.00 8 1338725 34 89289680
Necrotising ulcerative gingivostomatitis 13.08 11.00 8 1338725 34 89289680
Mycobacterium test positive 13.06 11.00 18 1338715 253 89289461
Infusion site warmth 13.04 11.00 8 1338725 2170 89287544
Preterm premature rupture of membranes 13.03 11.00 4 1338729 1637 89288077
Infective scleritis 13.02 11.00 9 1338724 49 89289665
Gastrointestinal stoma complication 13.00 11.00 10 1338723 2409 89287305
Clear cell renal cell carcinoma 13.00 11.00 52 1338681 1528 89288186
Genital herpes zoster 12.98 11.00 7 1338726 22 89289692
Femoroacetabular impingement 12.98 11.00 7 1338726 22 89289692
Dermatopathic lymphadenopathy 12.98 11.00 7 1338726 22 89289692
Device failure 12.98 11.00 55 1338678 6842 89282872
Congenital joint malformation 12.96 11.00 6 1338727 12 89289702
Cholesteatoma 12.95 11.00 15 1338718 175 89289539
Oral lichen planus 12.95 11.00 33 1338700 758 89288956
Oligoarthritis 12.95 11.00 27 1338706 541 89289173
Feeling of despair 12.92 11.00 17 1338716 3187 89286527
Glycogenic acanthosis 12.92 11.00 4 1338729 0 89289714
CSF myelin basic protein increased 12.92 11.00 4 1338729 0 89289714
T-cell lymphoma stage IV 12.92 11.00 4 1338729 0 89289714
Bladder papilloma 12.92 11.00 4 1338729 0 89289714
Leptotrichia infection 12.92 11.00 4 1338729 0 89289714
Angioimmunoblastic T-cell lymphoma stage III 12.92 11.00 4 1338729 0 89289714
Anorectal varices 12.92 11.00 4 1338729 0 89289714
Peripheral T-cell lymphoma unspecified stage III 12.92 11.00 4 1338729 0 89289714
Dysphotopsia 12.92 11.00 4 1338729 0 89289714
Merkel cell polyomavirus infection 12.92 11.00 4 1338729 0 89289714
Vaccine breakthrough infection 12.92 11.00 4 1338729 0 89289714
Peripheral T-cell lymphoma unspecified stage II 12.92 11.00 4 1338729 0 89289714
Bursa injury 12.92 11.00 4 1338729 0 89289714
Anogenital dysplasia 12.90 11.00 8 1338725 35 89289679
Thrombotic thrombocytopenic purpura 12.90 11.00 26 1338707 4112 89285602
Libido decreased 12.89 11.00 15 1338718 2967 89286747
Post procedural inflammation 12.89 11.00 13 1338720 128 89289586
Fear-related avoidance of activities 12.88 11.00 15 1338718 176 89289538
Gastric stenosis 12.88 11.00 10 1338723 67 89289647
International normalised ratio decreased 12.83 11.00 32 1338701 4692 89285022
Left ventricular hypertrophy 12.83 11.00 47 1338686 6097 89283617
Lupus vasculitis 12.82 11.00 28 1338705 580 89289134
Discontinued product administered 12.81 11.00 12 1338721 107 89289607
Angina unstable 12.81 11.00 58 1338675 7085 89282629
Ocular hypertension 12.80 11.00 54 1338679 1626 89288088
Tendon operation 12.79 11.00 20 1338713 317 89289397
Urine output increased 12.78 11.00 5 1338728 1757 89287957
Urticaria 12.77 11.00 4281 1334452 308453 88981261
Herpes simplex meningoencephalitis 12.76 11.00 7 1338726 23 89289691
Ligament rupture 12.76 11.00 97 1338636 3651 89286063
Gelatinous transformation of the bone marrow 12.76 11.00 5 1338728 5 89289709
Noninfective chorioretinitis 12.76 11.00 5 1338728 5 89289709
Gingival hyperpigmentation 12.76 11.00 5 1338728 5 89289709
Tenosynovitis stenosans 12.73 11.00 101 1338632 3852 89285862
Hyperphosphataemia 12.73 11.00 22 1338711 3689 89286025
Impaired quality of life 12.71 11.00 253 1338480 22891 89266823
Thymoma 12.71 11.00 18 1338715 260 89289454
Subdural hygroma 12.71 11.00 18 1338715 260 89289454
Small intestinal haemorrhage 12.71 11.00 9 1338724 2262 89287452
Alcohol interaction 12.68 11.00 5 1338728 1749 89287965
Body height decreased 12.67 11.00 114 1338619 11835 89277879
Placental disorder 12.66 11.00 4 1338729 1607 89288107
Angiotensin converting enzyme increased 12.66 11.00 11 1338722 88 89289626
Engraftment syndrome 12.66 11.00 31 1338702 694 89289020
Intestinal ischaemia 12.65 11.00 78 1338655 8805 89280909
Transitional cell carcinoma 12.60 11.00 31 1338702 696 89289018
Nasal obstruction 12.57 11.00 12 1338721 2600 89287114
Mucocutaneous disorder 12.57 11.00 8 1338725 37 89289677
Scar excision 12.54 11.00 10 1338723 70 89289644
Hepatitis B surface antigen positive 12.54 11.00 10 1338723 70 89289644
Localised oedema 12.53 11.00 48 1338685 6146 89283568
Hyperkeratosis 12.53 11.00 157 1338576 6771 89282943
Enterocolitis 12.52 11.00 97 1338636 10393 89279321
Vascular rupture 12.51 11.00 57 1338676 1776 89287938
Polyomavirus-associated nephropathy 12.50 11.00 11 1338722 2479 89287235
Glucose tolerance impaired 12.50 11.00 68 1338665 7917 89281797
Gastric neoplasm 12.48 11.00 20 1338713 324 89289390
Tongue neoplasm 12.47 11.00 11 1338722 90 89289624
Eczema herpeticum 12.47 11.00 16 1338717 209 89289505
Cell marker increased 12.46 11.00 18 1338715 265 89289449
Infectious mononucleosis 12.44 11.00 61 1338672 1960 89287754
HLA-B*27 positive 12.44 11.00 17 1338716 237 89289477
Sweat gland tumour 12.43 11.00 14 1338719 158 89289556
Therapeutic response delayed 12.43 11.00 34 1338699 816 89288898
Pneumocystis test positive 12.41 11.00 8 1338725 38 89289676
Frontotemporal dementia 12.40 11.00 22 1338711 389 89289325
Diffuse alveolar damage 12.39 11.00 40 1338693 1055 89288659
Anal prolapse 12.37 11.00 11 1338722 91 89289623
Blood catecholamines decreased 12.36 11.00 6 1338727 14 89289700
Ovarian epithelial cancer stage III 12.36 11.00 6 1338727 14 89289700
Cranial nerve injury 12.36 11.00 6 1338727 14 89289700
Conjunctivitis bacterial 12.36 11.00 22 1338711 390 89289324
Congestive hepatopathy 12.33 11.00 16 1338717 3017 89286697
Radiation pneumonitis 12.32 11.00 6 1338727 1852 89287862
Parosmia 12.32 11.00 58 1338675 7011 89282703
Tracheal stenosis 12.31 11.00 18 1338715 268 89289446
Tonsil cancer 12.29 11.00 19 1338714 298 89289416
T-cell type acute leukaemia 12.29 11.00 13 1338720 136 89289578
Chorea 12.29 11.00 8 1338725 2102 89287612
Mycobacterium ulcerans infection 12.25 11.00 8 1338725 39 89289675
Lip squamous cell carcinoma 12.24 11.00 14 1338719 161 89289553
Incontinence 12.23 11.00 133 1338600 13302 89276412
Jaw cyst 12.22 11.00 13 1338720 137 89289577
Bronchioloalveolar carcinoma 12.21 11.00 10 1338723 73 89289641
Pancreatitis 12.20 11.00 877 1337856 68949 89220765
Ovarian adenoma 12.17 11.00 18 1338715 271 89289443
Gastrointestinal infection 12.12 11.00 229 1338504 10761 89278953
Herpes virus infection 12.12 11.00 146 1338587 6238 89283476
Intermenstrual bleeding 12.11 11.00 83 1338650 9140 89280574
Overwork 12.10 11.00 9 1338724 56 89289658
Purpura fulminans 12.10 11.00 11 1338722 94 89289620
Stomatitis haemorrhagic 12.10 11.00 11 1338722 94 89289620
CSF cell count increased 12.10 11.00 8 1338725 40 89289674
Butterfly rash 12.09 11.00 64 1338669 2121 89287593
Weight fluctuation 12.05 11.00 212 1338521 19537 89270177
Ileostomy 12.05 11.00 59 1338674 1895 89287819
Essential tremor 12.04 11.00 3 1338730 1409 89288305
Thiopurine methyltransferase decreased 12.03 11.00 19 1338714 304 89289410
Ovarian epithelial cancer 12.02 11.00 20 1338713 335 89289379
Sleep disorder 12.01 11.00 3194 1335539 194836 89094878
Trigeminal neuralgia 12.01 11.00 27 1338706 4104 89285610
Troponin I increased 11.99 11.00 12 1338721 2543 89287171
Product leakage 11.99 11.00 3 1338730 1405 89288309
Influenza 11.99 11.00 2283 1336450 136981 89152733
Rash morbilliform 11.98 11.00 26 1338707 4003 89285711
Vena cava thrombosis 11.96 11.00 12 1338721 2540 89287174
Residual urine volume increased 11.92 11.00 11 1338722 96 89289618
Gastric cyst 11.92 11.00 11 1338722 96 89289618
Brain death 11.92 11.00 26 1338707 3995 89285719
Diabetic eye disease 11.92 11.00 14 1338719 166 89289548
Endometriosis 11.91 11.00 143 1338590 6105 89283609
Erythematotelangiectatic rosacea 11.91 11.00 12 1338721 118 89289596
Antineutrophil cytoplasmic antibody positive 11.90 11.00 31 1338702 722 89288992
Breast mass 11.89 11.00 201 1338532 9246 89280468
Glomerulonephritis rapidly progressive 11.88 11.00 44 1338689 1246 89288468
Bursitis infective 11.87 11.00 49 1338684 1461 89288253
Posthaemorrhagic hydrocephalus 11.86 11.00 9 1338724 58 89289656
Follicular lymphoma 11.85 11.00 21 1338712 371 89289343
Parapsoriasis 11.83 11.00 12 1338721 119 89289595
Sensation of foreign body 11.83 11.00 51 1338682 6315 89283399
Product name confusion 11.83 11.00 12 1338721 119 89289595
Peritonsillar abscess 11.82 11.00 27 1338706 577 89289137
Giant cell arteritis 11.82 11.00 81 1338652 2948 89286766
Histiocytic sarcoma 11.80 11.00 10 1338723 77 89289637
Combined immunodeficiency 11.80 11.00 13 1338720 143 89289571
Local reaction 11.80 11.00 32 1338701 764 89288950
Pustule 11.79 11.00 78 1338655 2805 89286909
Bronchitis bacterial 11.77 11.00 37 1338696 962 89288752
Glomerular filtration rate increased 11.74 11.00 8 1338725 2052 89287662
Intestinal sepsis 11.72 11.00 19 1338714 311 89289403
Lupus nephritis 11.71 11.00 116 1338617 4716 89284998
Respiratory rate increased 11.70 11.00 166 1338567 15835 89273879
Portal tract inflammation 11.70 11.00 10 1338723 78 89289636
Gingival ulceration 11.69 11.00 38 1338695 1006 89288708
Chorioretinopathy 11.69 11.00 34 1338699 846 89288868
Multiple system atrophy 11.69 11.00 15 1338718 196 89289518
JC polyomavirus test positive 11.68 11.00 6 1338727 1796 89287918
Nail bed inflammation 11.67 11.00 6 1338727 1795 89287919
Breast pain 11.67 11.00 98 1338635 10320 89279394
Tuberculosis of central nervous system 11.65 11.00 20 1338713 344 89289370
Pericarditis fungal 11.62 11.00 9 1338724 60 89289654
Follicular thyroid cancer 11.62 11.00 9 1338724 60 89289654
Subacute combined cord degeneration 11.61 11.00 16 1338717 225 89289489
Pulse waveform abnormal 11.61 11.00 10 1338723 79 89289635
Escherichia infection 11.59 11.00 165 1338568 15730 89273984
Postpartum haemorrhage 11.59 11.00 11 1338722 2390 89287324
Electrocardiogram repolarisation abnormality 11.59 11.00 3 1338730 1373 89288341
Infection protozoal 11.57 11.00 7 1338726 29 89289685
Haemoglobin increased 11.55 11.00 64 1338669 7417 89282297
Erysipelas 11.54 11.00 193 1338540 8859 89280855
Post transplant distal limb syndrome 11.53 11.00 20 1338713 347 89289367
Anaplastic thyroid cancer 11.51 11.00 8 1338725 44 89289670
Inflammatory bowel disease 11.51 11.00 122 1338611 5049 89284665
Uterine cancer 11.50 11.00 126 1338607 5259 89284455
Pseudarthrosis 11.49 11.00 23 1338710 447 89289267
Enterococcal gastroenteritis 11.49 11.00 5 1338728 8 89289706
Conjunctival deposit 11.49 11.00 5 1338728 8 89289706
Myxoid liposarcoma 11.49 11.00 5 1338728 8 89289706
Malignant syphilis 11.49 11.00 5 1338728 8 89289706
Torulopsis infection 11.49 11.00 5 1338728 8 89289706
Oral candidiasis 11.48 11.00 418 1338315 35037 89254677
Ischaemic cardiomyopathy 11.45 11.00 13 1338720 2600 89287114
Breast neoplasm 11.43 11.00 50 1338683 1530 89288184
Homicidal ideation 11.43 11.00 6 1338727 1774 89287940
Large intestine anastomosis 11.40 11.00 7 1338726 30 89289684
Chlamydia test positive 11.40 11.00 7 1338726 30 89289684
Ischaemia 11.39 11.00 40 1338693 5255 89284459
Behaviour disorder 11.38 11.00 33 1338700 4602 89285112
Skin disorder 11.38 11.00 657 1338076 36049 89253665
Toxic leukoencephalopathy 11.37 11.00 33 1338700 820 89288894
Moraxella infection 11.36 11.00 23 1338710 451 89289263
Candida pneumonia 11.35 11.00 15 1338718 202 89289512
Muscle haemorrhage 11.33 11.00 20 1338713 3326 89286388
Herpes simplex reactivation 11.33 11.00 37 1338696 982 89288732
Felty's syndrome 11.33 11.00 11 1338722 103 89289611
Toxoplasma serology positive 11.33 11.00 6 1338727 18 89289696
Spinal cord compression 11.32 11.00 36 1338697 4875 89284839
Vasculitis 11.32 11.00 426 1338307 22267 89267447
Malignant mediastinal neoplasm 11.31 11.00 46 1338687 1362 89288352
Gallbladder empyema 11.28 11.00 9 1338724 63 89289651
Panic reaction 11.28 11.00 34 1338699 4683 89285031
Sensory level abnormal 11.26 11.00 13 1338720 151 89289563
Ocular discomfort 11.26 11.00 52 1338681 6318 89283396
Hyperparathyroidism 11.25 11.00 20 1338713 3317 89286397
Tongue biting 11.23 11.00 9 1338724 2124 89287590
Multiple-drug resistance 11.22 11.00 68 1338665 7708 89282006
Pancreatic failure 11.21 11.00 4 1338729 1488 89288226
Palatal ulcer 11.19 11.00 15 1338718 205 89289509
Tetany 11.17 11.00 13 1338720 2571 89287143
Ventricular dysfunction 11.16 11.00 24 1338709 3707 89286007
Post procedural discomfort 11.15 11.00 3 1338730 1338 89288376
Engraft failure 11.14 11.00 20 1338713 357 89289357
Vulval cancer stage III 11.13 11.00 5 1338728 9 89289705
Fontanelle bulging 11.13 11.00 5 1338728 9 89289705
Dermatitis bullous 11.13 11.00 98 1338635 10218 89279496
Papilloma viral infection 11.12 11.00 54 1338679 1728 89287986
Joint surgery 11.12 11.00 23 1338710 458 89289256
Pneumonia influenzal 11.12 11.00 10 1338723 2230 89287484
Strabismus 11.12 11.00 12 1338721 2456 89287258
Mammoplasty 11.12 11.00 30 1338703 714 89289000
Squamous cell carcinoma of the vagina 11.10 11.00 6 1338727 19 89289695
Aortic elongation 11.10 11.00 6 1338727 19 89289695
Presbyacusis 11.08 11.00 80 1338653 2962 89286752
Staphylococcal infection 11.07 11.00 845 1337888 47594 89242120
Human T-cell lymphotropic virus type I infection 11.07 11.00 9 1338724 65 89289649
Rheumatic fever 11.06 11.00 2489 1336244 150632 89139082
Pertussis 11.06 11.00 34 1338699 873 89288841
Ligament operation 11.06 11.00 7 1338726 32 89289682
Choroid melanoma 11.06 11.00 7 1338726 32 89289682
Prerenal failure 11.04 11.00 9 1338724 2106 89287608
Gastroenteritis cryptosporidial 11.04 11.00 10 1338723 85 89289629
Cranial nerve palsies multiple 11.04 11.00 10 1338723 85 89289629
Paronychia 11.04 11.00 71 1338662 7935 89281779
Toe amputation 11.04 11.00 60 1338673 2009 89287705
Mycoplasma test positive 11.03 11.00 12 1338721 130 89289584
Oxygen therapy 11.00 11.00 18 1338715 3084 89286630

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 5154.23 11.65 15251 387571 614946 41603567
Death 1578.73 11.65 1289 401533 469896 41748617
Rheumatoid arthritis 1542.49 11.65 1953 400869 40487 42178026
Drug intolerance 1512.71 11.65 2720 400102 77704 42140809
Joint swelling 1480.11 11.65 2454 400368 65568 42152945
Treatment failure 1468.15 11.65 2337 400485 60287 42158226
Arthralgia 1247.53 11.65 4515 398307 200723 42017790
Synovitis 1207.16 11.65 1073 401749 14494 42204019
Psoriasis 1100.74 11.65 1786 401036 46818 42171695
Psoriatic arthropathy 1082.96 11.65 1257 401565 23710 42194803
Mucosal inflammation 992.36 11.65 1720 401102 47654 42170859
Drug abuse 822.97 11.65 40 402782 104731 42113782
Musculoskeletal stiffness 806.07 11.65 1724 401098 56041 42162472
Lymphoproliferative disorder 749.80 11.65 438 402384 2869 42215644
Completed suicide 741.39 11.65 42 402780 96423 42122090
Acute graft versus host disease 690.60 11.65 593 402229 7622 42210891
Therapeutic product effect incomplete 688.74 11.65 1839 400983 69100 42149413
Therapeutic product effect decreased 683.35 11.65 1283 401539 37867 42180646
Arthropathy 678.53 11.65 1094 401728 28503 42190010
Hypotension 640.11 11.65 902 401920 256729 41961784
Febrile neutropenia 603.39 11.65 3395 399427 182308 42036205
Dyspnoea 593.38 11.65 2171 400651 440450 41778063
Arthritis 565.55 11.65 1237 401585 40828 42177685
Contraindicated product administered 564.14 11.65 923 401899 24349 42194164
Leukoencephalopathy 561.65 11.65 426 402396 4528 42213985
Chronic graft versus host disease 560.25 11.65 461 402361 5564 42212949
Constipation 558.51 11.65 430 402392 161861 42056652
Pancytopenia 557.15 11.65 2397 400425 115346 42103167
Stomatitis 522.37 11.65 1338 401484 48991 42169522
Drug hypersensitivity 520.84 11.65 2088 400734 97301 42121212
Drug clearance decreased 497.82 11.65 290 402532 1888 42216625
Rhabdomyolysis 452.33 11.65 93 402729 77926 42140587
Hyperkalaemia 446.09 11.65 106 402716 80352 42138161
Dizziness 407.89 11.65 1116 401706 248138 41970375
Dehydration 405.36 11.65 445 402377 141322 42077191
Acute graft versus host disease in skin 401.86 11.65 420 402402 7004 42211509
Off label use 396.41 11.65 8328 394494 630007 41588506
Posterior reversible encephalopathy syndrome 382.37 11.65 536 402286 12285 42206228
Bone erosion 380.61 11.65 323 402499 4080 42214433
Fall 368.15 11.65 1071 401751 233449 41985064
C-reactive protein abnormal 361.44 11.65 442 402380 8819 42209694
Pain 350.12 11.65 3694 399128 241154 41977359
Drug ineffective for unapproved indication 349.44 11.65 1095 401727 45068 42173445
Somnolence 346.91 11.65 497 402325 140608 42077905
Osteoarthritis 337.41 11.65 726 402096 23679 42194834
Bradycardia 331.96 11.65 198 402624 85286 42133227
Hyponatraemia 327.49 11.65 286 402536 101176 42117337
Intentional overdose 322.81 11.65 50 402772 51406 42167107
Graft versus host disease 322.77 11.65 497 402325 12428 42206085
C-reactive protein increased 322.13 11.65 1322 401500 62238 42156275
Red blood cell sedimentation rate increased 315.65 11.65 428 402394 9496 42209017
Hospitalisation 307.64 11.65 159 402663 74171 42144342
Cardiac arrest 306.00 11.65 349 402473 108971 42109542
Pneumocystis jirovecii pneumonia 302.14 11.65 708 402114 24473 42194040
Confusional state 293.30 11.65 725 402097 166872 42051641
Ankylosing spondylitis 292.10 11.65 347 402475 6709 42211804
Epstein-Barr virus associated lymphoproliferative disorder 281.18 11.65 212 402610 2231 42216282
Neurotoxicity 279.43 11.65 661 402161 22990 42195523
Venoocclusive liver disease 278.38 11.65 411 402411 9891 42208622
Syncope 277.50 11.65 318 402504 99088 42119425
Tuberculosis 277.37 11.65 406 402416 9693 42208820
Inflammation 275.86 11.65 824 401998 33023 42185490
Mouth ulceration 270.50 11.65 498 402324 14465 42204048
Electrocardiogram QT prolonged 264.06 11.65 64 402758 47881 42170632
Hypoglycaemia 259.87 11.65 120 402702 59734 42158779
Apparent death 258.79 11.65 241 402581 3467 42215046
Malignant neoplasm progression 255.45 11.65 393 402429 108007 42110506
Atrial fibrillation 254.37 11.65 591 402231 139002 42079511
Plasma cell myeloma 249.65 11.65 70 402752 47508 42171005
Decreased appetite 248.12 11.65 962 401860 192175 42026338
Anaemia 246.21 11.65 1595 401227 278683 41939830
International normalised ratio increased 243.38 11.65 76 402746 48092 42170421
Asthenia 242.57 11.65 1606 401216 279187 41939326
Mobility decreased 242.31 11.65 810 402012 34496 42184017
Diarrhoea 240.47 11.65 2997 399825 457852 41760661
Acute kidney injury 236.10 11.65 2277 400545 365060 41853453
Bone marrow failure 235.84 11.65 769 402053 32324 42186189
Rheumatoid nodule 235.19 11.65 208 402614 2787 42215726
Product use in unapproved indication 233.13 11.65 2717 400105 181739 42036774
Fatigue 232.92 11.65 2818 400004 432823 41785690
Pain in extremity 231.92 11.65 2308 400514 148296 42070217
Hallucination 230.63 11.65 128 402694 57379 42161134
Cardiac failure congestive 230.17 11.65 282 402540 85320 42133193
Myelopathy 229.47 11.65 202 402620 2689 42215824
Drug interaction 223.15 11.65 1542 401280 265457 41953056
Graft versus host disease in gastrointestinal tract 221.31 11.65 258 402564 4885 42213628
Sedation 220.21 11.65 18 402804 30457 42188056
Liver function test increased 219.21 11.65 543 402279 19455 42199058
Epstein-Barr virus infection 216.89 11.65 355 402467 9363 42209150
Red blood cell sedimentation rate abnormal 216.59 11.65 222 402600 3614 42214899
Angiocentric lymphoma 215.17 11.65 104 402718 433 42218080
Hand deformity 214.44 11.65 219 402603 3549 42214964
Overdose 213.96 11.65 419 402403 104845 42113668
Aggression 213.80 11.65 75 402747 44088 42174425
Agitation 211.47 11.65 178 402644 64136 42154377
Uveitis 206.36 11.65 338 402484 8920 42209593
Epstein Barr virus positive mucocutaneous ulcer 205.13 11.65 103 402719 474 42218039
Product dose omission issue 204.57 11.65 759 402063 153606 42064907
Blood glucose increased 201.08 11.65 240 402582 73459 42145054
Diffuse large B-cell lymphoma 199.80 11.65 337 402485 9117 42209396
Cardio-respiratory arrest 199.36 11.65 157 402665 58479 42160034
Loss of consciousness 198.81 11.65 355 402467 91999 42126514
Febrile bone marrow aplasia 198.25 11.65 350 402472 9831 42208682
Joint stiffness 197.91 11.65 390 402432 11932 42206581
Graft versus host disease in skin 195.72 11.65 244 402578 4968 42213545
Hypofibrinogenaemia 192.33 11.65 155 402667 1812 42216701
Lymphoma 192.19 11.65 421 402401 13900 42204613
Cystitis haemorrhagic 191.72 11.65 288 402534 7041 42211472
Dactylitis 191.09 11.65 125 402697 1026 42217487
Skin plaque 188.19 11.65 254 402568 5609 42212904
Anxiety 185.30 11.65 542 402280 118018 42100495
Neuroleptic malignant syndrome 183.28 11.65 4 402818 21468 42197045
Suicide attempt 182.85 11.65 104 402718 45996 42172517
Pulmonary fibrosis 182.07 11.65 611 402211 26070 42192443
Joint effusion 179.50 11.65 249 402573 5648 42212865
Suicidal ideation 178.02 11.65 118 402704 48043 42170470
Foetal exposure during pregnancy 177.48 11.65 114 402708 47197 42171316
Knee arthroplasty 176.34 11.65 306 402516 8475 42210038
Myelosuppression 174.61 11.65 802 402020 39659 42178854
Gastrointestinal disorder 174.16 11.65 887 401935 45766 42172747
Lactic acidosis 174.01 11.65 106 402716 45155 42173358
Metabolic acidosis 172.36 11.65 142 402680 51716 42166797
Immunosuppression 171.62 11.65 296 402526 8157 42210356
Haemoglobin decreased 170.51 11.65 659 402163 131812 42086701
Basal cell carcinoma 168.98 11.65 536 402286 22197 42196316
Intentional product misuse 168.41 11.65 202 402620 61698 42156815
Grip strength decreased 167.93 11.65 188 402634 3400 42215113
Haematotoxicity 167.22 11.65 340 402482 10645 42207868
Cytomegalovirus infection reactivation 166.65 11.65 343 402479 10835 42207678
Histoplasmosis disseminated 165.76 11.65 146 402676 1945 42216568
Polyarthritis 165.16 11.65 222 402600 4882 42213631
Condition aggravated 164.92 11.65 3416 399406 257338 41961175
Coma 163.19 11.65 159 402663 53395 42165118
Drug reaction with eosinophilia and systemic symptoms 162.51 11.65 98 402724 41977 42176536
Pneumonia aspiration 161.69 11.65 141 402681 49937 42168576
Infection 161.66 11.65 1695 401127 110373 42108140
Hypokalaemia 161.37 11.65 268 402554 71453 42147060
Gastrointestinal haemorrhage 157.64 11.65 440 402382 97286 42121227
Cardiogenic shock 155.39 11.65 71 402751 35569 42182944
Acute graft versus host disease in intestine 154.86 11.65 189 402633 3762 42214751
Joint range of motion decreased 154.16 11.65 269 402553 7484 42211029
Foot deformity 152.77 11.65 213 402609 4855 42213658
Arthritis bacterial 152.66 11.65 230 402592 5638 42212875
Sarcoidosis 152.28 11.65 181 402641 3501 42215012
Tremor 151.51 11.65 443 402379 96486 42122027
Hepatic enzyme increased 150.11 11.65 840 401982 44944 42173569
Serotonin syndrome 149.33 11.65 31 402791 25814 42192699
Haemophagocytic lymphohistiocytosis 148.80 11.65 444 402378 17778 42200735
Acute lymphocytic leukaemia recurrent 148.64 11.65 179 402643 3512 42215001
Blood creatine phosphokinase increased 147.88 11.65 143 402679 48195 42170318
Hepatotoxicity 141.54 11.65 541 402281 24626 42193887
Diverticulitis 139.32 11.65 503 402319 22270 42196243
Thrombotic microangiopathy 139.02 11.65 379 402443 14403 42204110
Epidermal necrosis 138.75 11.65 86 402736 636 42217877
Pulmonary tuberculosis 137.99 11.65 212 402610 5289 42213224
Enthesopathy 135.34 11.65 196 402626 4632 42213881
Contraindication to medical treatment 135.24 11.65 91 402731 787 42217726
Cutaneous leishmaniasis 135.17 11.65 61 402761 209 42218304
Orthostatic hypotension 133.12 11.65 61 402761 30509 42188004
Rheumatoid factor positive 132.98 11.65 88 402734 738 42217775
Blood creatinine increased 132.85 11.65 561 402261 109442 42109071
Disability 130.06 11.65 215 402607 5718 42212795
Epstein-Barr virus infection reactivation 127.00 11.65 140 402682 2487 42216026
Skin ulcer 125.29 11.65 527 402295 25074 42193439
Chronic graft versus host disease in skin 125.04 11.65 111 402711 1495 42217018
Oedema peripheral 124.02 11.65 765 402057 135311 42083202
Depressed level of consciousness 123.74 11.65 163 402659 47807 42170706
Mucocutaneous ulceration 123.14 11.65 71 402751 452 42218061
Delirium 122.12 11.65 192 402630 52327 42166186
Faecal calprotectin increased 121.26 11.65 148 402674 2946 42215567
Lennox-Gastaut syndrome 121.06 11.65 44 402778 68 42218445
Cardiac failure 119.94 11.65 560 402262 106296 42112217
Chemotherapeutic drug level increased 119.72 11.65 58 402764 243 42218270
Respiratory depression 119.08 11.65 18 402804 18850 42199663
Synovial cyst 118.35 11.65 135 402687 2494 42216019
Tenosynovitis 117.86 11.65 181 402641 4514 42213999
Restlessness 117.40 11.65 65 402757 29184 42189329
Drug specific antibody present 117.24 11.65 166 402656 3840 42214673
Abnormal behaviour 116.39 11.65 52 402770 26399 42192114
Extrapyramidal disorder 115.03 11.65 11 402811 16401 42202112
Chondropathy 114.78 11.65 94 402728 1126 42217387
Tachycardia 114.50 11.65 528 402294 100559 42117954
Herpes zoster 113.63 11.65 692 402130 38185 42180328
Skin lesion 113.08 11.65 533 402289 26641 42191872
Wheezing 113.03 11.65 216 402606 54565 42163948
Hypomagnesaemia 111.92 11.65 65 402757 28423 42190090
Troponin increased 109.85 11.65 23 402799 19039 42199474
Abdominal distension 109.09 11.65 332 402490 71403 42147110
Platelet count decreased 108.89 11.65 814 402008 137767 42080746
Hepatic fibrosis 108.75 11.65 178 402644 4694 42213819
End stage renal disease 108.72 11.65 14 402808 16544 42201969
Hepatic steatosis 107.69 11.65 445 402377 21003 42197510
Hypophosphataemia 107.68 11.65 32 402790 20913 42197600
Hypocalcaemia 107.41 11.65 77 402745 30096 42188417
Sopor 107.03 11.65 4 402818 13198 42205315
Diabetic ketoacidosis 106.52 11.65 39 402783 22328 42196185
Miosis 105.92 11.65 5 402817 13441 42205072
Respiratory arrest 105.90 11.65 69 402753 28355 42190158
Ventricular fibrillation 105.76 11.65 78 402744 30045 42188468
Sacroiliitis 105.24 11.65 111 402711 1871 42216642
Vomiting 104.97 11.65 2018 400804 287705 41930808
Visceral leishmaniasis 104.57 11.65 87 402735 1067 42217446
Dry mouth 104.40 11.65 134 402688 39745 42178768
Drug withdrawal syndrome 103.59 11.65 37 402785 21512 42197001
Hallucination, visual 102.93 11.65 35 402787 20985 42197528
Chest pain 102.89 11.65 834 401988 138696 42079817
Sleep disorder due to a general medical condition 102.78 11.65 20 402802 17433 42201080
Venoocclusive disease 102.62 11.65 154 402668 3761 42214752
Disseminated tuberculosis 102.53 11.65 130 402692 2694 42215819
Angioedema 101.91 11.65 152 402670 42325 42176188
Nodule 101.01 11.65 304 402518 12230 42206283
Full blood count abnormal 100.27 11.65 81 402741 29795 42188718
Rheumatoid lung 99.35 11.65 77 402745 847 42217666
Loss of personal independence in daily activities 98.81 11.65 807 402015 49009 42169504
Blood pressure fluctuation 98.58 11.65 509 402313 26399 42192114
Musculoskeletal discomfort 98.29 11.65 252 402570 9224 42209289
Anti-cyclic citrullinated peptide antibody positive 97.85 11.65 105 402717 1807 42216706
Disease recurrence 97.59 11.65 545 402277 29133 42189380
Urinary retention 97.50 11.65 155 402667 42059 42176454
Intentional self-injury 97.10 11.65 14 402808 15188 42203325
Haemoptysis 97.03 11.65 180 402642 45987 42172526
Fibromyalgia 97.03 11.65 150 402672 3763 42214750
Psychotic disorder 95.78 11.65 81 402741 29127 42189386
Pruritus 95.56 11.65 1234 401588 187537 42030976
Abscess 95.17 11.65 324 402498 13924 42204589
Tuberculin test positive 94.88 11.65 83 402739 1095 42217418
Cerebrovascular accident 94.44 11.65 535 402287 96625 42121888
Delusion 93.11 11.65 14 402808 14720 42203793
General physical health deterioration 90.77 11.65 952 401870 150294 42068219
Melaena 90.69 11.65 141 402681 38605 42179908
Hyperglycaemia 90.15 11.65 186 402636 45673 42172840
Therapeutic response decreased 89.38 11.65 628 402194 36384 42182129
Angioimmunoblastic T-cell lymphoma 88.79 11.65 51 402771 322 42218191
Sleep disorder due to general medical condition, insomnia type 88.39 11.65 88 402734 1381 42217132
Nasopharyngitis 88.22 11.65 1196 401626 82800 42135713
Impaired work ability 87.95 11.65 283 402539 11808 42206705
Hyperhidrosis 87.63 11.65 499 402323 90013 42128500
Acute myocardial infarction 87.15 11.65 271 402551 57894 42160619
Insomnia 86.62 11.65 708 402114 117545 42100968
Spinal instability 86.05 11.65 60 402762 553 42217960
Myoclonus 86.05 11.65 27 402795 17038 42201475
Hypoxia 86.02 11.65 353 402469 69433 42149080
Adenovirus infection 85.55 11.65 195 402627 6614 42211899
Myalgia 85.50 11.65 544 402278 95536 42122977
Rheumatoid factor negative 84.81 11.65 73 402749 941 42217572
Blood phosphorus increased 83.68 11.65 10 402812 12515 42205998
Therapy non-responder 83.05 11.65 820 402002 52539 42165974
Squamous cell carcinoma 82.18 11.65 290 402532 12692 42205821
Asthma 82.04 11.65 307 402515 62007 42156506
Bursitis 82.01 11.65 182 402640 6062 42212451
Hip arthroplasty 81.70 11.65 165 402657 5140 42213373
Pulmonary mass 81.29 11.65 337 402485 15928 42202585
Wrong technique in product usage process 81.23 11.65 176 402646 42459 42176054
Aphthous ulcer 80.91 11.65 175 402647 5726 42212787
Cytomegalovirus chorioretinitis 80.24 11.65 151 402671 4460 42214053
Multiple sclerosis relapse 78.60 11.65 19 402803 14245 42204268
Atlantoaxial instability 78.40 11.65 50 402772 391 42218122
Spermatozoa abnormal 78.32 11.65 27 402795 32 42218481
Cytomegalovirus infection 77.92 11.65 548 402274 31758 42186755
Dyskinesia 77.77 11.65 75 402747 25315 42193198
Sinus bradycardia 77.62 11.65 22 402800 14831 42203682
Latent tuberculosis 77.51 11.65 87 402735 1578 42216935
Leukaemia recurrent 77.22 11.65 92 402730 1784 42216729
Foetal methotrexate syndrome 77.09 11.65 21 402801 0 42218513
Ileal stenosis 76.90 11.65 92 402730 1792 42216721
Blood potassium increased 76.13 11.65 40 402782 18496 42200017
Akathisia 75.98 11.65 6 402816 10445 42208068
Aspiration 75.85 11.65 37 402785 17849 42200664
Histoplasmosis 75.81 11.65 89 402733 1698 42216815
BK virus infection 75.50 11.65 218 402604 8566 42209947
Viral haemorrhagic cystitis 74.80 11.65 90 402732 1764 42216749
Paranoia 74.75 11.65 20 402802 14006 42204507
Myocardial infarction 74.61 11.65 780 402042 123229 42095284
Disorientation 74.60 11.65 144 402678 36245 42182268
Hepatic cirrhosis 74.48 11.65 376 402446 19326 42199187
Coronary artery disease 74.46 11.65 259 402563 53461 42165052
Intentional product use issue 74.27 11.65 1020 401802 70813 42147700
Transient ischaemic attack 74.09 11.65 128 402694 33611 42184902
Cognitive disorder 73.80 11.65 131 402691 34041 42184472
Unresponsive to stimuli 73.76 11.65 114 402708 31289 42187224
Anal fistula 73.75 11.65 174 402648 6039 42212474
Finger deformity 73.67 11.65 84 402738 1551 42216962
Osteopenia 73.63 11.65 175 402647 6103 42212410
B-cell lymphoma 73.52 11.65 151 402671 4762 42213751
Balance disorder 73.50 11.65 219 402603 47426 42171087
Seronegative arthritis 73.05 11.65 73 402749 1151 42217362
Malignant melanoma 72.95 11.65 225 402597 9175 42209338
Lung neoplasm malignant 72.80 11.65 366 402456 18781 42199732
Mycobacterium tuberculosis complex test positive 72.77 11.65 81 402741 1455 42217058
No adverse event 72.76 11.65 163 402659 38858 42179655
Hypertriglyceridaemia 71.84 11.65 235 402587 9891 42208622
Atrial flutter 71.19 11.65 37 402785 17214 42201299
Substance abuse 71.17 11.65 3 402819 8902 42209611
Osteonecrosis 71.05 11.65 318 402504 15547 42202966
Acute graft versus host disease in liver 70.87 11.65 90 402732 1868 42216645
Oral mucosa erosion 70.85 11.65 68 402754 1018 42217495
Injury 70.62 11.65 64 402758 22252 42196261
Haematemesis 70.57 11.65 110 402712 30089 42188424
Poisoning deliberate 70.48 11.65 7 402815 10127 42208386
Dry skin 70.45 11.65 228 402594 48110 42170403
Neuropathy peripheral 70.45 11.65 619 402203 101234 42117279
Inflammatory marker increased 70.42 11.65 180 402642 6576 42211937
Torsade de pointes 68.34 11.65 3 402819 8591 42209922
Inappropriate schedule of product administration 68.01 11.65 1279 401543 94623 42123890
Sleep disorder 67.93 11.65 230 402592 47865 42170648
Unevaluable event 67.45 11.65 139 402683 34149 42184364
Stevens-Johnson syndrome 67.37 11.65 66 402756 22112 42196401
Hallucination, auditory 67.34 11.65 28 402794 14836 42203677
Mycobacterial infection 67.17 11.65 103 402719 2565 42215948
Blood urea increased 67.03 11.65 130 402692 32663 42185850
Cytokine release syndrome 67.02 11.65 207 402615 44320 42174193
X-ray abnormal 66.98 11.65 48 402774 464 42218049
Wrist deformity 66.53 11.65 42 402780 322 42218191
Cardiac disorder 66.42 11.65 238 402584 48694 42169819
Blood pressure decreased 66.42 11.65 304 402518 58028 42160485
Bone cyst 66.37 11.65 80 402742 1571 42216942
Cutaneous T-cell lymphoma 66.33 11.65 88 402734 1910 42216603
Dislocation of vertebra 66.24 11.65 45 402777 396 42218117
Myasthenia gravis 66.01 11.65 35 402787 16102 42202411
Urinary tract infection 65.78 11.65 610 402212 98674 42119839
Demyelination 65.73 11.65 119 402703 3410 42215103
Chronic obstructive pulmonary disease 65.46 11.65 340 402482 62774 42155739
Mucosal ulceration 65.18 11.65 72 402750 1282 42217231
Full blood count decreased 65.01 11.65 59 402763 20501 42198012
Hyperthyroidism 64.99 11.65 27 402795 14314 42204199
Dystonia 64.91 11.65 20 402802 12770 42205743
Oxidative stress 64.72 11.65 27 402795 72 42218441
Poisoning 64.51 11.65 29 402793 14670 42203843
Hospice care 64.46 11.65 4 402818 8509 42210004
Epstein-Barr virus associated lymphoma 64.40 11.65 64 402758 1002 42217511
Rash 64.26 11.65 2061 400761 274893 41943620
Vision blurred 64.08 11.65 275 402547 53424 42165089
Pneumonia cryptococcal 63.80 11.65 75 402747 1433 42217080
Upper gastrointestinal haemorrhage 63.78 11.65 118 402704 30181 42188332
Graft versus host disease in liver 63.58 11.65 78 402744 1561 42216952
Haemorrhage 63.52 11.65 325 402497 60238 42158275
Musculoskeletal pain 63.38 11.65 535 402287 32805 42185708
Cytomegalovirus viraemia 63.29 11.65 229 402593 10148 42208365
Sensitivity to weather change 63.28 11.65 87 402735 1956 42216557
Product quality issue 63.17 11.65 46 402776 17836 42200677
Flushing 62.46 11.65 163 402659 36865 42181648
Thrombosis 62.44 11.65 385 402437 68126 42150387
Fluid retention 62.35 11.65 128 402694 31491 42187022
Skin erosion 62.34 11.65 104 402718 2787 42215726
Disturbance in attention 62.26 11.65 117 402705 29749 42188764
Onychoclasis 62.06 11.65 99 402723 2553 42215960
Engraftment syndrome 61.94 11.65 71 402751 1319 42217194
Bladder transitional cell carcinoma 61.40 11.65 99 402723 2577 42215936
Hyperphosphataemia 61.37 11.65 23 402799 12981 42205532
Blood glucose decreased 60.93 11.65 29 402793 14190 42204323
Product use issue 60.92 11.65 1042 401780 75709 42142804
Chronic kidney disease 60.71 11.65 235 402587 47006 42171507
Joint ankylosis 60.57 11.65 77 402745 1600 42216913
Pleurisy 60.47 11.65 146 402676 5144 42213369
Kidney transplant rejection 60.38 11.65 6 402816 8677 42209836
Peripheral swelling 60.29 11.65 1193 401629 89077 42129436
Activated partial thromboplastin time prolonged 60.07 11.65 38 402784 15865 42202648
Vein rupture 59.56 11.65 59 402763 920 42217593
Ventricular tachycardia 59.55 11.65 122 402700 30038 42188475
Mineral metabolism disorder 59.51 11.65 41 402781 370 42218143
Complications of bone marrow transplant 59.41 11.65 34 402788 213 42218300
Acne cystic 59.33 11.65 47 402775 535 42217978
Seizure 59.15 11.65 793 402029 119768 42098745
Clinodactyly 58.96 11.65 35 402787 237 42218276
Rash maculo-papular 58.85 11.65 171 402651 37332 42181181
Hepatitis E 58.78 11.65 106 402716 3028 42215485
Gastrointestinal inflammation 58.24 11.65 132 402690 4460 42214053
Hepatic enzyme abnormal 58.18 11.65 113 402709 3419 42215094
Squamous cell carcinoma of lung 58.08 11.65 88 402734 2168 42216345
Haematocrit decreased 57.87 11.65 155 402667 34753 42183760
Joint destruction 57.69 11.65 40 402782 365 42218148
Anaphylactic shock 57.53 11.65 83 402739 23434 42195079
Oedema 57.44 11.65 274 402548 51727 42166786
Spondyloarthropathy 57.31 11.65 56 402766 858 42217655
Dyspnoea exertional 57.30 11.65 261 402561 49887 42168626
Depression 57.02 11.65 726 402096 110637 42107876
Lymph node tuberculosis 56.84 11.65 44 402778 483 42218030
Aplasia 56.80 11.65 135 402687 4708 42213805
Chronic graft versus host disease in liver 56.59 11.65 49 402773 637 42217876
Superior sagittal sinus thrombosis 56.33 11.65 37 402785 306 42218207
Intracranial hypotension 56.08 11.65 41 402781 410 42218103
Alanine aminotransferase abnormal 56.03 11.65 136 402686 4808 42213705
Hyperbilirubinaemia 55.73 11.65 360 402462 20275 42198238
Premature baby 55.38 11.65 83 402739 23070 42195443
Treatment noncompliance 55.38 11.65 177 402645 37495 42181018
Immunodeficiency 55.19 11.65 173 402649 7117 42211396
Bicytopenia 55.07 11.65 104 402718 3080 42215433
Depressed mood 54.81 11.65 85 402737 23299 42195214
Cytogenetic abnormality 54.60 11.65 55 402767 876 42217637
Abscess limb 54.46 11.65 120 402702 3977 42214536
Erythrodermic psoriasis 54.45 11.65 59 402763 1027 42217486
Syringe issue 54.36 11.65 8 402814 8548 42209965
Dysgeusia 54.30 11.65 155 402667 34034 42184479
Hypothyroidism 54.30 11.65 141 402681 31943 42186570
Joint arthroplasty 54.18 11.65 56 402766 921 42217592
Swelling 54.16 11.65 773 402049 54112 42164401
Haematuria 54.14 11.65 322 402500 57477 42161036
Blood sodium decreased 54.07 11.65 55 402767 18107 42200406
Glioma 54.04 11.65 42 402780 464 42218049
Arachnoiditis 53.99 11.65 38 402784 356 42218157
Prostate cancer 53.75 11.65 652 402170 43991 42174522
Arrhythmia 53.47 11.65 198 402624 40119 42178394
Post transplant distal limb syndrome 53.35 11.65 40 402782 417 42218096
Pseudostroke 53.23 11.65 24 402798 82 42218431
Non-alcoholic steatohepatitis 53.14 11.65 56 402766 943 42217570
Irritability 52.85 11.65 117 402705 28011 42190502
Progressive multifocal leukoencephalopathy 52.24 11.65 232 402590 11304 42207209
Toxic leukoencephalopathy 52.18 11.65 48 402774 679 42217834
Lymphadenopathy 52.03 11.65 513 402309 32852 42185661
Leukopenia 51.99 11.65 994 401828 73752 42144761
Eosinophilia 51.63 11.65 150 402672 32749 42185764
Erectile dysfunction 51.58 11.65 98 402724 24815 42193698
Haematoma 51.48 11.65 118 402704 27905 42190608
Meningitis listeria 51.43 11.65 46 402776 626 42217887
Blood pressure systolic increased 51.16 11.65 445 402377 27523 42190990
Inflammatory bowel disease 51.09 11.65 107 402715 3422 42215091
Muscle rigidity 51.06 11.65 25 402797 12034 42206479
Head injury 50.98 11.65 72 402750 20510 42198003
Retinal pigment epitheliopathy 50.93 11.65 31 402791 221 42218292
Pneumonia fungal 50.91 11.65 196 402626 8950 42209563
Aspergillus infection 50.85 11.65 289 402533 15548 42202965
Pneumonia legionella 50.81 11.65 83 402739 2185 42216328
Memory impairment 50.71 11.65 273 402549 49949 42168564
Limb discomfort 50.63 11.65 247 402575 12520 42205993
Salivary hypersecretion 50.57 11.65 20 402802 10923 42207590
Pulmonary oedema 50.30 11.65 296 402526 52976 42165537
Chronic graft versus host disease oral 50.28 11.65 37 402785 374 42218139
Pulmonary toxicity 50.26 11.65 188 402634 8467 42210046
White blood cell count increased 50.13 11.65 237 402585 44850 42173663
Hypovolaemia 49.87 11.65 23 402799 11462 42207051
Accidental exposure to product 49.86 11.65 72 402750 20321 42198192
Blood potassium decreased 49.81 11.65 72 402750 20312 42198201
Dysphagia 49.80 11.65 443 402379 72276 42146237
Withdrawal syndrome 49.65 11.65 40 402782 14735 42203778
Leukoerythroblastosis 49.56 11.65 19 402803 37 42218476
Liver disorder 49.49 11.65 583 402239 39061 42179452
Renal impairment 49.48 11.65 738 402084 109490 42109023
Ill-defined disorder 49.47 11.65 293 402529 16003 42202510
Incorrect disposal of product 49.41 11.65 37 402785 385 42218128
Subdural hygroma 49.32 11.65 38 402784 414 42218099
Anhedonia 48.88 11.65 7 402815 7633 42210880
Ascites 48.83 11.65 324 402498 56354 42162159
Chronic graft versus host disease in intestine 48.51 11.65 38 402784 425 42218088
Altered state of consciousness 48.44 11.65 130 402692 29129 42189384
Drug tolerance decreased 48.38 11.65 83 402739 2277 42216236
Lung adenocarcinoma 48.32 11.65 135 402687 5204 42213309
Dysphonia 48.17 11.65 125 402697 28325 42190188
Bone marrow oedema 48.15 11.65 50 402772 827 42217686
Myelodysplastic syndrome 48.11 11.65 374 402448 22371 42196142
Cystitis viral 48.01 11.65 59 402763 1183 42217330
Medial tibial stress syndrome 47.99 11.65 19 402803 42 42218471
Nightmare 47.85 11.65 103 402719 24909 42193604
Labelled drug-drug interaction medication error 47.76 11.65 46 402776 15536 42202977
Arthritis infective 47.66 11.65 114 402708 3992 42214521
Palpitations 47.57 11.65 283 402539 50514 42167999
Central nervous system leukaemia 47.23 11.65 35 402787 358 42218155
White blood cell count decreased 47.21 11.65 746 402076 109650 42108863
Device leakage 47.20 11.65 19 402803 10266 42208247
Fear of injection 47.19 11.65 75 402747 1928 42216585
Axial spondyloarthritis 47.14 11.65 40 402782 505 42218008
Device occlusion 47.06 11.65 11 402811 8439 42210074
Drug dependence 46.87 11.65 131 402691 28963 42189550
Interstitial lung disease 46.84 11.65 1020 401802 77442 42141071
Staphylococcal sepsis 46.83 11.65 223 402599 11191 42207322
Hypertransaminasaemia 46.75 11.65 192 402630 9035 42209478
Diffuse large B-cell lymphoma recurrent 46.66 11.65 126 402696 4760 42213753
Amnesia 46.58 11.65 127 402695 28310 42190203
Clear cell renal cell carcinoma 46.55 11.65 59 402763 1222 42217291
Mental status changes 46.46 11.65 222 402600 41893 42176620
Blood cholesterol increased 46.42 11.65 116 402706 26625 42191888
Cerebral venous thrombosis 46.09 11.65 53 402769 988 42217525
Hiccups 46.08 11.65 29 402793 12142 42206371
Juvenile idiopathic arthritis 45.40 11.65 86 402736 2553 42215960
Episcleritis 45.35 11.65 27 402795 184 42218329
Subdural haematoma 45.34 11.65 94 402728 23044 42195469
Scleroderma 45.27 11.65 69 402753 1709 42216804
Osteoporosis 45.25 11.65 268 402554 14638 42203875
Spinal pain 45.10 11.65 154 402668 6628 42211885
Heparin-induced thrombocytopenia 44.74 11.65 5 402817 6592 42211921
Chemotherapeutic drug level above therapeutic 44.70 11.65 16 402806 23 42218490
Chest discomfort 44.69 11.65 385 402437 63231 42155282
Presyncope 44.67 11.65 90 402732 22297 42196216
Arteriosclerosis 44.49 11.65 63 402759 17926 42200587
Herpes simplex 44.48 11.65 158 402664 6937 42211576
Pulmonary vasculitis 44.45 11.65 4 402818 6262 42212251
Central nervous system lymphoma 44.44 11.65 60 402762 1325 42217188
Bronchospasm 44.41 11.65 34 402788 12851 42205662
Therapeutic product ineffective 44.39 11.65 54 402768 1071 42217442
Metastatic bronchial carcinoma 44.39 11.65 34 402788 367 42218146
Tooth fracture 44.15 11.65 112 402710 4072 42214441
Anal fissure 44.05 11.65 129 402693 5110 42213403
Psoriasis area severity index increased 44.00 11.65 20 402802 70 42218443
Lip swelling 43.95 11.65 70 402752 18983 42199530
Bronchopulmonary aspergillosis 43.63 11.65 324 402498 19105 42199408
Intervertebral disc space narrowing 43.63 11.65 54 402768 1091 42217422
Parkinsonism 43.51 11.65 23 402799 10600 42207913
Shock haemorrhagic 43.10 11.65 54 402768 16188 42202325
Fear 43.09 11.65 25 402797 10940 42207573
Priapism 43.09 11.65 5 402817 6402 42212111
Frequent bowel movements 43.08 11.65 348 402474 21059 42197454
Micturition urgency 42.82 11.65 30 402792 11868 42206645
Skin cancer 42.80 11.65 218 402604 11244 42207269
Pollakiuria 42.78 11.65 93 402729 22412 42196101
Peritonitis bacterial 42.72 11.65 7 402815 6908 42211605
Thinking abnormal 42.60 11.65 8 402814 7153 42211360
Gout 42.52 11.65 130 402692 27925 42190588
Post transplant lymphoproliferative disorder 42.50 11.65 185 402637 8935 42209578
Abdominal discomfort 42.30 11.65 970 401852 74285 42144228
Lipoma 42.27 11.65 74 402748 2064 42216449
Hypothermia 41.90 11.65 34 402788 12481 42206032
Pulmonary hypertension 41.89 11.65 101 402721 23468 42195045
Red blood cell count decreased 41.87 11.65 163 402659 32552 42185961
Mycobacterium marinum infection 41.70 11.65 37 402785 498 42218015
Rheumatoid factor increased 41.44 11.65 42 402780 674 42217839
Intestinal polyp 41.34 11.65 57 402765 1285 42217228
Blood calcium decreased 41.33 11.65 27 402795 11081 42207432
Pustular psoriasis 41.20 11.65 73 402749 2056 42216457
Oral disorder 40.95 11.65 119 402703 4693 42213820
Injection site haemorrhage 40.91 11.65 219 402603 11517 42206996
Glioblastoma multiforme 40.91 11.65 46 402776 836 42217677
Steatohepatitis 40.86 11.65 35 402787 448 42218065
Minimal residual disease 40.73 11.65 39 402783 582 42217931
Acute myeloid leukaemia 40.64 11.65 354 402468 21902 42196611
Tardive dyskinesia 40.63 11.65 8 402814 6916 42211597
Therapy partial responder 40.58 11.65 326 402496 19695 42198818
Forced expiratory volume decreased 40.43 11.65 11 402811 7619 42210894
Lupus-like syndrome 40.37 11.65 91 402731 3063 42215450
Borderline leprosy 40.23 11.65 15 402807 26 42218487
Varicella zoster virus infection 40.17 11.65 81 402741 2520 42215993
Cutaneous lymphoma 39.99 11.65 21 402801 108 42218405
Muscle twitching 39.45 11.65 32 402790 11748 42206765
Cytopenia 39.41 11.65 292 402530 17205 42201308
Inflammatory pain 39.41 11.65 37 402785 538 42217975
Leukocytosis 39.32 11.65 146 402676 29562 42188951
Localised infection 39.29 11.65 328 402494 20045 42198468
Failure to thrive 39.19 11.65 20 402802 9402 42209111
Euglycaemic diabetic ketoacidosis 39.12 11.65 4 402818 5656 42212857
Oral herpes 39.03 11.65 158 402664 7386 42211127
Lethargy 38.92 11.65 271 402551 46619 42171894
Conjunctivitis allergic 38.80 11.65 5 402817 5906 42212607
Supraventricular tachycardia 38.76 11.65 36 402786 12372 42206141
Electrocardiogram abnormal 38.65 11.65 24 402798 10121 42208392
Speech disorder 38.62 11.65 143 402679 28978 42189535
Joint lock 38.49 11.65 56 402766 1329 42217184
Nail psoriasis 38.24 11.65 21 402801 120 42218393
Facial paralysis 38.21 11.65 226 402596 12337 42206176
Tuberculosis of genitourinary system 38.18 11.65 18 402804 70 42218443
Mucosal toxicity 38.13 11.65 28 402794 282 42218231
Peritoneal tuberculosis 38.12 11.65 30 402792 338 42218175
Bronchiolitis obliterans syndrome 38.05 11.65 28 402794 283 42218230
Non-Hodgkin's lymphoma 38.04 11.65 57 402765 1390 42217123
Hidradenitis 38.04 11.65 63 402759 1678 42216835
Psychomotor hyperactivity 37.66 11.65 29 402793 10929 42207584
Mucosal erosion 37.65 11.65 47 402775 958 42217555
Cushingoid 37.58 11.65 93 402729 3329 42215184
Heart rate increased 37.53 11.65 322 402500 52933 42165580
Tenderness 37.50 11.65 175 402647 8708 42209805
Short stature 37.46 11.65 32 402790 408 42218105
Swollen joint count increased 37.42 11.65 27 402795 264 42218249
Shock 37.32 11.65 145 402677 28976 42189537
Right ventricular failure 37.24 11.65 22 402800 9533 42208980
Arthrodesis 37.19 11.65 36 402786 545 42217968
Bundle branch block right 37.16 11.65 15 402807 8091 42210422
Genital erosion 37.11 11.65 28 402794 295 42218218
Mass 36.78 11.65 172 402650 8567 42209946
Acidosis 36.76 11.65 37 402785 12242 42206271
Hypervolaemia 36.60 11.65 105 402717 23020 42195493
Complications of transplanted kidney 36.42 11.65 4 402818 5346 42213167
Normochromic normocytic anaemia 36.34 11.65 20 402802 9011 42209502
Ureaplasma infection 36.25 11.65 37 402785 599 42217914
Pyoderma gangrenosum 36.22 11.65 66 402756 1901 42216612
Cytology abnormal 36.19 11.65 30 402792 366 42218147
Hyperlipidaemia 36.07 11.65 95 402727 21421 42197092
Cerebral haemorrhage 36.00 11.65 218 402604 38748 42179765
Enterovesical fistula 35.99 11.65 45 402777 919 42217594
Therapy interrupted 35.97 11.65 100 402722 22150 42196363
Angina pectoris 35.93 11.65 174 402648 32722 42185791
Neutrophil count increased 35.88 11.65 84 402738 19720 42198793
Lung cancer metastatic 35.85 11.65 84 402738 2902 42215611
Blood loss anaemia 35.77 11.65 24 402798 9712 42208801
Chromaturia 35.70 11.65 60 402762 15929 42202584
Anal abscess 35.64 11.65 158 402664 7692 42210821
Reactive gastropathy 35.63 11.65 35 402787 540 42217973
Neutropenic colitis 35.62 11.65 108 402714 4362 42214151
JC virus infection 35.51 11.65 84 402738 2920 42215593
Blood stem cell transplant failure 35.46 11.65 32 402790 441 42218072
Brain natriuretic peptide increased 35.43 11.65 10 402812 6760 42211753
Granuloma 35.42 11.65 101 402721 3940 42214573
Cataract 35.12 11.65 443 402379 30161 42188352
Mucocutaneous leishmaniasis 34.96 11.65 19 402803 106 42218407
Molluscum contagiosum 34.63 11.65 28 402794 329 42218184
Myocarditis 34.58 11.65 80 402742 18858 42199655
Cerebral venous sinus thrombosis 34.55 11.65 39 402783 712 42217801
Meningitis aseptic 34.51 11.65 107 402715 4375 42214138
Incorrect route of product administration 34.47 11.65 116 402706 24189 42194324
Palmar-plantar erythrodysaesthesia syndrome 34.41 11.65 91 402731 20491 42198022
Aortic stenosis 34.28 11.65 20 402802 8725 42209788
Glycosylated haemoglobin increased 34.26 11.65 43 402779 12881 42205632
Transplant rejection 34.19 11.65 47 402775 13541 42204972
Swelling face 34.17 11.65 139 402683 27415 42191098
Thirst 34.07 11.65 22 402800 9086 42209427
Lymphocyte count decreased 34.04 11.65 141 402681 27668 42190845
Oropharyngeal pain 34.02 11.65 578 402244 41932 42176581
Blood pressure diastolic abnormal 33.84 11.65 131 402691 5997 42212516
Intestinal stenosis 33.79 11.65 79 402743 2725 42215788
Hepatic encephalopathy 33.75 11.65 65 402757 16377 42202136
Abnormal dreams 33.74 11.65 18 402804 8253 42210260
Neutrophil count decreased 33.72 11.65 410 402412 63005 42155508
Obliterative bronchiolitis 33.45 11.65 54 402768 1407 42217106
Obsessive-compulsive disorder 33.41 11.65 11 402811 6732 42211781
Breath sounds abnormal 33.37 11.65 39 402783 12054 42206459
Bradyphrenia 33.25 11.65 5 402817 5257 42213256
Hepatitis B reactivation 33.15 11.65 107 402715 4471 42214042
Prescribed underdose 33.12 11.65 29 402793 10253 42208260
Leishmaniasis 33.09 11.65 30 402792 416 42218097
Decreased immune responsiveness 32.83 11.65 66 402756 2049 42216464
Hypoxic-ischaemic encephalopathy 32.74 11.65 5 402817 5197 42213316
Dermatitis psoriasiform 32.67 11.65 66 402756 2056 42216457
Synovial disorder 32.62 11.65 22 402800 191 42218322
Faeces discoloured 32.60 11.65 70 402752 16944 42201569
Behaviour disorder 32.42 11.65 13 402809 7041 42211472
Tonsil cancer 32.35 11.65 47 402775 1114 42217399
Myelitis 32.23 11.65 45 402777 1027 42217486
Sudden death 32.21 11.65 68 402754 16561 42201952
Cytotoxic oedema 32.16 11.65 22 402800 196 42218317
Nocardiosis 32.04 11.65 115 402707 5075 42213438
Nipple swelling 32.03 11.65 28 402794 369 42218144
Acute myeloid leukaemia recurrent 31.98 11.65 89 402733 3423 42215090
Respiratory acidosis 31.95 11.65 10 402812 6321 42212192
Mycobacterium chelonae infection 31.82 11.65 47 402775 1131 42217382
Toxicity to various agents 31.64 11.65 1807 401015 227329 41991184
Appendicitis 31.60 11.65 95 402727 20518 42197995
Product substitution issue 31.60 11.65 36 402786 11254 42207259
Engraft failure 31.58 11.65 33 402789 550 42217963
Serum procollagen type III N-terminal propeptide increased 31.46 11.65 14 402808 46 42218467
Taste disorder 31.43 11.65 30 402792 10177 42208336
Large intestinal stenosis 31.36 11.65 62 402760 1901 42216612
Dermatitis acneiform 31.34 11.65 17 402805 7722 42210791
Mania 31.33 11.65 32 402790 10515 42207998
Asphyxia 31.30 11.65 20 402802 8306 42210207
Ankle deformity 31.18 11.65 22 402800 207 42218306
Dysstasia 31.12 11.65 234 402588 13852 42204661
Mucormycosis 31.10 11.65 142 402680 7001 42211512
Ventricular extrasystoles 31.07 11.65 49 402773 13341 42205172
Impaired healing 31.01 11.65 271 402551 16782 42201731
Mycobacterium haemophilum infection 30.81 11.65 29 402793 423 42218090
Iridocyclitis 30.80 11.65 66 402756 2145 42216368
Oesophageal stenosis 30.75 11.65 63 402759 1983 42216530
Anaemia megaloblastic 30.69 11.65 27 402795 359 42218154
Bradypnoea 30.64 11.65 3 402819 4390 42214123
Pulmonary thrombosis 30.63 11.65 158 402664 8190 42210323
Testicular seminoma (pure) 30.62 11.65 21 402801 188 42218325
Soft tissue swelling 30.60 11.65 37 402785 729 42217784
Septic arthritis staphylococcal 30.56 11.65 31 402791 498 42218015
Drug eruption 30.43 11.65 343 402479 22732 42195781
Hyperthermia 30.15 11.65 45 402777 12529 42205984
Skin mass 29.98 11.65 107 402715 4709 42213804
Abdominal pain upper 29.92 11.65 575 402247 82034 42136479
Bone tuberculosis 29.90 11.65 29 402793 440 42218073
Granulomatous pneumonitis 29.87 11.65 12 402810 28 42218485
Anger 29.86 11.65 48 402774 12970 42205543
Intervertebral discitis 29.83 11.65 80 402742 3010 42215503
Blood magnesium decreased 29.82 11.65 18 402804 7708 42210805
Blood fibrinogen decreased 29.78 11.65 54 402768 1549 42216964
Food intolerance 29.78 11.65 55 402767 1601 42216912
Craniosynostosis 29.77 11.65 28 402794 408 42218105
Electrocardiogram QRS complex prolonged 29.74 11.65 9 402813 5814 42212699
Faecaloma 29.74 11.65 11 402811 6259 42212254
T-cell lymphoma 29.72 11.65 45 402777 1108 42217405
Cerebral salt-wasting syndrome 29.58 11.65 14 402808 55 42218458
Bursitis infective 29.56 11.65 34 402788 634 42217879
Blood calcium increased 29.53 11.65 22 402800 8432 42210081
Pemphigoid 29.52 11.65 39 402783 11428 42207085
Osteosarcoma recurrent 29.51 11.65 17 402805 108 42218405
Rebound effect 29.43 11.65 143 402679 7236 42211277
Diffuse large B-cell lymphoma stage IV 29.42 11.65 31 402791 522 42217991
Neuritis 29.35 11.65 11 402811 6209 42212304
Acute lymphocytic leukaemia 29.34 11.65 85 402737 3346 42215167
Atypical mycobacterial infection 29.27 11.65 49 402773 1317 42217196
Dysarthria 29.26 11.65 238 402584 39569 42178944
Gastrooesophageal reflux disease 29.21 11.65 278 402544 44745 42173768
Exposure via skin contact 29.19 11.65 6 402816 5032 42213481
Tooth loss 29.10 11.65 96 402726 4058 42214455
Undifferentiated connective tissue disease 29.05 11.65 16 402806 92 42218421
Hepatitis cholestatic 28.96 11.65 30 402792 9794 42208719
Atrioventricular block complete 28.90 11.65 39 402783 11325 42207188
Ependymoma malignant 28.83 11.65 11 402811 21 42218492
Circulatory collapse 28.83 11.65 120 402702 23516 42194997
Psychomotor skills impaired 28.54 11.65 7 402815 5197 42213316
Cerebral toxoplasmosis 28.51 11.65 62 402760 2036 42216477
Bone formation decreased 28.51 11.65 11 402811 22 42218491
Myelitis transverse 28.44 11.65 48 402774 1299 42217214
Spinal cord disorder 28.42 11.65 40 402782 920 42217593
Colitis ulcerative 28.40 11.65 375 402447 25800 42192713
Endocarditis bacterial 28.26 11.65 46 402776 1207 42217306
Scleritis 28.24 11.65 36 402786 750 42217763
Eye infection toxoplasmal 28.22 11.65 24 402798 304 42218209
Staphylococcal bacteraemia 28.20 11.65 191 402631 10930 42207583
Polychondritis 28.20 11.65 26 402796 369 42218144
Renal cell carcinoma 28.11 11.65 115 402707 5402 42213111
Schizophrenia 28.07 11.65 35 402787 10515 42207998
Bronchial carcinoma 27.99 11.65 41 402781 979 42217534
Blood pressure systolic abnormal 27.98 11.65 115 402707 5413 42213100
Gastrointestinal toxicity 27.92 11.65 92 402730 3887 42214626
Hypersensitivity 27.84 11.65 888 401934 71482 42147031
Superficial spreading melanoma stage unspecified 27.77 11.65 21 402801 222 42218291
Rheumatic disorder 27.77 11.65 33 402789 638 42217875
Neck pain 27.74 11.65 418 402404 29596 42188917
Ischaemic stroke 27.67 11.65 112 402710 22121 42196392
Exposure during pregnancy 27.66 11.65 24 402798 8524 42209989
Human rhinovirus test positive 27.65 11.65 23 402799 282 42218231
Acute monocytic leukaemia 27.64 11.65 26 402796 379 42218134
Pneumocystis jirovecii infection 27.56 11.65 74 402748 2786 42215727
Haemorrhagic stroke 27.53 11.65 18 402804 7384 42211129
Tropical infectious disease 27.52 11.65 12 402810 37 42218476
Photosensitivity reaction 27.49 11.65 210 402612 12492 42206021
Symptom recurrence 27.44 11.65 50 402772 1440 42217073
Fungal infection 27.31 11.65 296 402526 19426 42199087
Hypersomnia 27.30 11.65 61 402761 14557 42203956
Body temperature decreased 27.23 11.65 231 402591 14182 42204331
Face oedema 27.21 11.65 55 402767 13611 42204902
Infectious pleural effusion 27.18 11.65 79 402743 3116 42215397
Xanthogranuloma 27.13 11.65 14 402808 69 42218444
Hypogammaglobulinaemia 27.10 11.65 199 402623 11692 42206821
Epstein-Barr viraemia 27.05 11.65 64 402758 2225 42216288
Sinus tachycardia 27.01 11.65 102 402720 20551 42197962
Hepatopulmonary syndrome 27.00 11.65 16 402806 108 42218405
Cytomegalovirus test positive 26.92 11.65 96 402726 4223 42214290
Post inflammatory pigmentation change 26.92 11.65 28 402794 464 42218049
Pachymeningitis 26.91 11.65 18 402804 154 42218359
Ischaemic cardiomyopathy 26.89 11.65 14 402808 6508 42212005
Listeriosis 26.81 11.65 48 402774 1363 42217150
Electrolyte imbalance 26.81 11.65 78 402744 17023 42201490
Neurosarcoidosis 26.79 11.65 20 402802 207 42218306
Neoplasm recurrence 26.77 11.65 71 402751 2653 42215860
Mydriasis 26.75 11.65 26 402796 8744 42209769
Nail dystrophy 26.73 11.65 26 402796 396 42218117
Pharyngeal ulceration 26.73 11.65 26 402796 396 42218117
Microangiopathy 26.72 11.65 53 402769 1629 42216884
Atrioventricular block first degree 26.67 11.65 14 402808 6477 42212036
Product administration interrupted 26.62 11.65 7 402815 4959 42213554
Lentigo 26.56 11.65 36 402786 798 42217715
Atrioventricular block 26.54 11.65 31 402791 9584 42208929
Limb deformity 26.52 11.65 30 402792 549 42217964
Cardiac failure chronic 26.45 11.65 31 402791 9570 42208943
Cerebral infarction 26.43 11.65 179 402643 30990 42187523
Angioimmunoblastic T-cell lymphoma stage IV 26.41 11.65 9 402813 10 42218503
Visual impairment 26.38 11.65 270 402552 42843 42175670
Osteonecrosis of jaw 26.28 11.65 92 402730 18957 42199556
Jaundice 26.26 11.65 205 402617 34384 42184129
Intervertebral disc annular tear 26.24 11.65 10 402812 19 42218494
Antisynthetase syndrome 26.24 11.65 17 402805 137 42218376
Venous injury 26.23 11.65 24 402798 337 42218176
Pericarditis 26.22 11.65 217 402605 13227 42205286
Granulomatosis with polyangiitis 26.14 11.65 49 402773 1443 42217070
Sweat gland tumour 26.07 11.65 26 402796 409 42218104
Chills 26.02 11.65 683 402139 93383 42125130
Leprosy 25.96 11.65 16 402806 117 42218396
Staphylococcal infection 25.96 11.65 500 402322 37143 42181370
Muscle haemorrhage 25.88 11.65 4 402818 4121 42214392
Cerebellar tumour 25.74 11.65 16 402806 119 42218394
Angioimmunoblastic T-cell lymphoma stage III 25.70 11.65 7 402815 0 42218513
Mental disorder 25.60 11.65 86 402736 17943 42200570
Rash pruritic 25.58 11.65 199 402623 33404 42185109
Meningitis haemophilus 25.53 11.65 8 402814 5 42218508
Pneumonia klebsiella 25.51 11.65 93 402729 4136 42214377
Ophthalmic herpes zoster 25.38 11.65 41 402781 1069 42217444
Coma scale abnormal 25.31 11.65 6 402816 4559 42213954
Gliosis 25.29 11.65 20 402802 227 42218286
Adult T-cell lymphoma/leukaemia 25.29 11.65 18 402804 172 42218341
Empyema 25.28 11.65 92 402730 4088 42214425
Flatulence 25.23 11.65 137 402685 25015 42193498
Pyopneumothorax 25.19 11.65 12 402810 48 42218465
Ventricular arrhythmia 25.13 11.65 14 402808 6265 42212248
Blood alkaline phosphatase increased 25.10 11.65 200 402622 33397 42185116
Muscle spasms 25.07 11.65 620 402202 85424 42133089
Antithrombin III decreased 25.04 11.65 29 402793 545 42217968
Bradykinesia 25.01 11.65 10 402812 5426 42213087
Hepatitis B virus test positive 24.91 11.65 23 402799 327 42218186
Nephropathy toxic 24.85 11.65 256 402566 16582 42201931
Transaminases increased 24.83 11.65 443 402379 32442 42186071
Muscle spasticity 24.82 11.65 17 402805 6805 42211708
Polyuria 24.81 11.65 35 402787 9976 42208537
Intestinal sepsis 24.81 11.65 33 402789 718 42217795
Mesenteritis 24.75 11.65 11 402811 36 42218477
Steroid diabetes 24.72 11.65 71 402751 2781 42215732
Atrial septal defect 24.71 11.65 23 402799 7896 42210617
Knee operation 24.65 11.65 67 402755 2541 42215972
Bladder transitional cell carcinoma recurrent 24.62 11.65 18 402804 180 42218333
Second primary malignancy 24.61 11.65 165 402657 9410 42209103
Ageusia 24.60 11.65 45 402777 11560 42206953
Chronic graft versus host disease in eye 24.50 11.65 21 402801 269 42218244
Spondylitis 24.42 11.65 49 402773 1519 42216994
Ketoacidosis 24.38 11.65 10 402812 5342 42213171
Meningitis tuberculous 24.24 11.65 31 402791 648 42217865
Extranodal marginal zone B-cell lymphoma (MALT type) 24.21 11.65 22 402800 306 42218207
Sickle cell anaemia with crisis 24.19 11.65 8 402814 4882 42213631
Therapeutic product effect delayed 24.16 11.65 48 402774 1477 42217036
Faecal calprotectin abnormal 24.16 11.65 22 402800 307 42218206
Gastric disorder 24.09 11.65 194 402628 11728 42206785
Brain abscess 24.00 11.65 92 402730 4192 42214321
Pericarditis tuberculous 23.99 11.65 13 402809 72 42218441
Refusal of treatment by patient 23.91 11.65 10 402812 5281 42213232
Gastric haemorrhage 23.90 11.65 39 402783 10476 42208037
Infectious thyroiditis 23.87 11.65 15 402807 114 42218399
Acute promyelocytic leukaemia 23.79 11.65 32 402790 704 42217809
Mucosal disorder 23.78 11.65 59 402763 2115 42216398
Monoclonal B-cell lymphocytosis 23.77 11.65 12 402810 56 42218457
Thymoma benign 23.77 11.65 12 402810 56 42218457
Dysuria 23.75 11.65 184 402638 30912 42187601
Drug dose omission by device 23.73 11.65 13 402809 5873 42212640
Graft versus host disease in eye 23.70 11.65 22 402800 315 42218198
Laboratory test abnormal 23.69 11.65 124 402698 22854 42195659
Cystitis escherichia 23.67 11.65 18 402804 192 42218321
Hypersensitivity pneumonitis 23.65 11.65 56 402766 1948 42216565
Candida infection 23.61 11.65 310 402512 21300 42197213
Ventricular hypertrophy 23.61 11.65 8 402814 4808 42213705
Euphoric mood 23.58 11.65 16 402806 6437 42212076
Facial paresis 23.57 11.65 76 402746 3174 42215339
Injection site bruising 23.54 11.65 188 402634 11337 42207176
Orchitis 23.49 11.65 60 402762 2191 42216322
Iritis 23.47 11.65 52 402770 1730 42216783
Pulmonary arteriopathy 23.43 11.65 13 402809 76 42218437
Subarachnoid haemorrhage 23.43 11.65 65 402757 14407 42204106
Osteosclerosis 23.42 11.65 47 402775 1457 42217056
Fusarium infection 23.40 11.65 49 402773 1567 42216946
Pleuropericarditis 23.37 11.65 22 402800 321 42218192
Disseminated aspergillosis 23.37 11.65 51 402771 1679 42216834
Exposure to toxic agent 23.36 11.65 9 402813 4995 42213518
Antinuclear antibody positive 23.35 11.65 49 402773 1569 42216944
Enzyme abnormality 23.35 11.65 20 402802 256 42218257
Blood pressure diastolic increased 23.34 11.65 121 402701 6284 42212229
Aspiration bone marrow abnormal 23.24 11.65 15 402807 120 42218393
Salmonellosis 23.20 11.65 43 402779 1255 42217258
Prostatic specific antigen increased 23.18 11.65 82 402740 16843 42201670
Muscle oedema 23.17 11.65 19 402803 228 42218285
Dissociation 23.12 11.65 4 402818 3794 42214719
Shoulder arthroplasty 23.06 11.65 33 402789 771 42217742
Synovectomy 23.03 11.65 13 402809 79 42218434
Nodular regenerative hyperplasia 23.00 11.65 38 402784 1010 42217503
Post procedural infection 22.99 11.65 112 402710 5673 42212840
Lung perforation 22.98 11.65 8 402814 10 42218503
Neuralgia 22.90 11.65 145 402677 25502 42193011
Blood uric acid increased 22.88 11.65 73 402749 15474 42203039
Hepatic function abnormal 22.87 11.65 644 402178 50923 42167590
Urinary incontinence 22.87 11.65 116 402706 21552 42196961
Plasma cell myeloma recurrent 22.80 11.65 13 402809 5744 42212769
Heart rate decreased 22.78 11.65 478 402344 36054 42182459
Tricuspid valve incompetence 22.75 11.65 44 402778 11069 42207444
Blood pressure diastolic decreased 22.72 11.65 172 402650 10203 42208310
Electrocardiogram ST segment elevation 22.69 11.65 14 402808 5925 42212588
Prothrombin time prolonged 22.59 11.65 34 402788 9435 42209078
Fistula 22.58 11.65 140 402682 7772 42210741
Multiple allergies 22.53 11.65 4 402818 3724 42214789
Prescribed overdose 22.50 11.65 56 402766 12871 42205642
Lipodystrophy acquired 22.45 11.65 3 402819 3447 42215066
Tonsillar disorder 22.41 11.65 24 402798 412 42218101
Oropharyngeal oedema 22.39 11.65 13 402809 84 42218429
Diarrhoea haemorrhagic 22.39 11.65 137 402685 7570 42210943
Hodgkin's disease 22.32 11.65 33 402789 795 42217718
Hot flush 22.28 11.65 122 402700 22229 42196284
Seminoma 22.28 11.65 21 402801 307 42218206
Acute lymphocytic leukaemia refractory 22.27 11.65 15 402807 130 42218383
Varicella zoster pneumonia 22.19 11.65 19 402803 243 42218270
Corneal toxicity 22.15 11.65 8 402814 12 42218501
Somnambulism 22.15 11.65 3 402819 3412 42215101
Psychomotor retardation 22.11 11.65 7 402815 4392 42214121
Herpes simplex oesophagitis 22.07 11.65 19 402803 245 42218268
Dysphotopsia 22.03 11.65 6 402816 0 42218513
Liver injury 21.90 11.65 277 402545 18871 42199642
Graft versus host disease in lung 21.89 11.65 31 402791 717 42217796
Self-consciousness 21.89 11.65 15 402807 134 42218379
High density lipoprotein decreased 21.85 11.65 5 402817 3892 42214621
Osteolysis 21.83 11.65 79 402743 3501 42215012
Pulmonary cavitation 21.82 11.65 42 402780 1262 42217251
Systemic lupus erythematosus 21.80 11.65 157 402665 9167 42209346
Meniscus injury 21.77 11.65 62 402760 2417 42216096
Kounis syndrome 21.75 11.65 3 402819 3365 42215148
Intervertebral disc protrusion 21.74 11.65 179 402643 10893 42207620
International normalised ratio decreased 21.72 11.65 8 402814 4564 42213949
Cheilitis 21.72 11.65 64 402758 2544 42215969
Small intestinal stenosis 21.70 11.65 34 402788 863 42217650
C-reactive protein decreased 21.69 11.65 58 402764 2178 42216335
Joint tuberculosis 21.68 11.65 11 402811 52 42218461
Juvenile melanoma benign 21.65 11.65 12 402810 70 42218443
Follicular lymphoma 21.65 11.65 24 402798 429 42218084
Central nervous system mass 21.63 11.65 33 402789 818 42217695
Drug level increased 21.61 11.65 358 402464 25842 42192671
Colitis 21.60 11.65 585 402237 45987 42172526
Terminal state 21.60 11.65 91 402731 4332 42214181
Obstructive airways disorder 21.59 11.65 141 402681 24618 42193895
Wall motion score index abnormal 21.51 11.65 33 402789 822 42217691
Onycholysis 21.47 11.65 36 402786 969 42217544
Infection in an immunocompromised host 21.44 11.65 37 402785 1020 42217493
Enterovirus test positive 21.44 11.65 13 402809 92 42218421
HCoV-HKU1 infection 21.38 11.65 10 402812 38 42218475
Infective tenosynovitis 21.32 11.65 13 402809 93 42218420
Eye irritation 21.32 11.65 47 402775 11271 42207242
Rheumatoid vasculitis 21.28 11.65 19 402803 258 42218255
Herpes virus infection 21.27 11.65 80 402742 3612 42214901
Peritonsillar abscess 21.25 11.65 25 402797 478 42218035
Liver function test abnormal 21.24 11.65 427 402395 31964 42186549
Product administration error 21.23 11.65 95 402727 18248 42200265
Angina unstable 21.19 11.65 48 402774 11400 42207113
Cancer pain 21.19 11.65 4 402818 3563 42214950
Arthritis enteropathic 21.19 11.65 15 402807 142 42218371
Iris adhesions 21.16 11.65 19 402803 260 42218253
Autoimmune lymphoproliferative syndrome 21.01 11.65 17 402805 200 42218313
Malignant melanoma stage I 20.99 11.65 13 402809 96 42218417
Legionella infection 20.98 11.65 27 402795 568 42217945
Macule 20.98 11.65 54 402768 1981 42216532
Streptococcal bacteraemia 20.98 11.65 65 402757 2657 42215856
Skin dystrophy 20.91 11.65 7 402815 7 42218506
Eructation 20.87 11.65 13 402809 5473 42213040
Cartilage injury 20.84 11.65 27 402795 572 42217941
Septic shock 20.83 11.65 1063 401759 90609 42127904
Cutaneous T-cell lymphoma refractory 20.82 11.65 9 402813 27 42218486
Neoplasm malignant 20.73 11.65 316 402506 22427 42196086
Joint warmth 20.72 11.65 28 402794 619 42217894
Hepatitis acute 20.67 11.65 33 402789 8942 42209571
Musculoskeletal disorder 20.57 11.65 120 402702 6518 42211995
Marginal zone lymphoma 20.53 11.65 14 402808 124 42218389
Cardiomegaly 20.52 11.65 85 402737 16681 42201832
Colorectal cancer 20.50 11.65 11 402811 5027 42213486
C-reactive protein 20.49 11.65 12 402810 79 42218434
Terminal ileitis 20.45 11.65 27 402795 583 42217930
Pseudomonal sepsis 20.42 11.65 87 402735 4162 42214351
Acute coronary syndrome 20.37 11.65 72 402750 14793 42203720
White matter lesion 20.33 11.65 35 402787 963 42217550
Paraplegia 20.31 11.65 73 402749 3224 42215289
Tender joint count increased 20.28 11.65 16 402806 181 42218332
Arteriosclerosis coronary artery 20.27 11.65 99 402723 18578 42199935
Cubital tunnel syndrome 20.27 11.65 17 402805 211 42218302
Airway remodelling 20.25 11.65 33 402789 867 42217646
N-terminal prohormone brain natriuretic peptide increased 20.24 11.65 4 402818 3449 42215064
Blood glucose fluctuation 20.21 11.65 9 402813 4578 42213935
Refractoriness to platelet transfusion 20.13 11.65 12 402810 82 42218431
Actinomycotic pulmonary infection 20.13 11.65 9 402813 30 42218483
Myoglobin blood increased 20.10 11.65 5 402817 3677 42214836
Azotaemia 20.09 11.65 16 402806 5928 42212585
Atrial tachycardia 20.08 11.65 7 402815 4133 42214380
Neuroendocrine carcinoma of the skin 20.07 11.65 34 402788 923 42217590
Carcinoma in situ of skin 20.01 11.65 12 402810 83 42218430
Erythema multiforme 20.00 11.65 40 402782 9937 42208576
International normalised ratio abnormal 19.99 11.65 4 402818 3419 42215094
Bundle branch block left 19.98 11.65 19 402803 6457 42212056
Small cell lung cancer 19.98 11.65 54 402768 2041 42216472
Cutaneous symptom 19.95 11.65 22 402800 391 42218122
Thymus enlargement 19.92 11.65 10 402812 46 42218467
Skin bacterial infection 19.89 11.65 18 402804 249 42218264
Parakeratosis 19.88 11.65 17 402805 217 42218296
Extrapulmonary tuberculosis 19.88 11.65 15 402807 158 42218355
Dermatitis atopic 19.86 11.65 56 402766 12348 42206165
Benign prostatic hyperplasia 19.85 11.65 117 402705 20935 42197578
Arteriospasm coronary 19.79 11.65 10 402812 4728 42213785
Hyperlactacidaemia 19.67 11.65 9 402813 4507 42214006
Cholera 19.62 11.65 6 402816 3 42218510
Infusion site erythema 19.62 11.65 5 402817 3617 42214896
Catatonia 19.61 11.65 18 402804 6221 42212292
Drug level abnormal 19.61 11.65 19 402803 288 42218225
Leukoplakia 19.60 11.65 11 402811 66 42218447
Exostosis 19.57 11.65 105 402717 5526 42212987
Epstein-Barr virus test positive 19.51 11.65 28 402794 656 42217857
Herpes simplex encephalitis 19.50 11.65 21 402801 363 42218150
Proteinuria 19.48 11.65 132 402690 22851 42195662
Underdose 19.48 11.65 86 402736 16580 42201933
Ligament calcification 19.45 11.65 17 402805 224 42218289
Drug level below therapeutic 19.43 11.65 117 402705 6428 42212085
Lymphopenia 19.42 11.65 299 402523 21264 42197249
Increased appetite 19.35 11.65 34 402788 8872 42209641
Anaplastic large cell lymphoma T- and null-cell types 19.31 11.65 14 402808 138 42218375
Type 1 lepra reaction 19.27 11.65 10 402812 50 42218463
Atrial septal defect acquired 19.26 11.65 8 402814 21 42218492
SAPHO syndrome 19.26 11.65 22 402800 407 42218106
Silicosis 19.19 11.65 7 402815 11 42218502
Oligoarthritis 19.18 11.65 16 402806 197 42218316
Seasonal allergy 19.14 11.65 29 402793 8026 42210487
Adenoviral hepatitis 19.14 11.65 25 402797 534 42217979
Tongue disorder 19.14 11.65 101 402721 5282 42213231
Escherichia infection 19.14 11.65 178 402644 11218 42207295
Coordination abnormal 19.11 11.65 29 402793 8021 42210492
Alanine aminotransferase increased 19.05 11.65 1020 401802 87386 42131127
Psychiatric decompensation 19.05 11.65 8 402814 4214 42214299
Vertigo 19.05 11.65 220 402602 34127 42184386
Immobilisation syndrome 19.03 11.65 23 402799 453 42218060
Urine output decreased 19 11.65 47 402775 10826 42207687
Keratitis 18.96 11.65 48 402774 1743 42216770
Mood swings 18.91 11.65 34 402788 8792 42209721
Infusion site pain 18.90 11.65 14 402808 5381 42213132
Nail pitting 18.89 11.65 22 402800 416 42218097
Aplasia pure red cell 18.83 11.65 24 402798 7142 42211371
Drug metabolite level high 18.82 11.65 7 402815 12 42218501
Defaecation urgency 18.82 11.65 77 402745 3617 42214896
Lung neoplasm 18.80 11.65 91 402731 4597 42213916
Gallbladder oedema 18.79 11.65 17 402805 235 42218278
Cerebral thrombosis 18.78 11.65 34 402788 974 42217539
Tuberculous pleurisy 18.73 11.65 22 402800 420 42218093
Alveolitis 18.73 11.65 49 402773 1816 42216697
Macrocytosis 18.72 11.65 36 402786 1081 42217432
Hypophysitis 18.71 11.65 3 402819 3008 42215505
Ileostomy 18.70 11.65 36 402786 1082 42217431
Pneumonia cytomegaloviral 18.70 11.65 83 402739 4043 42214470
Cardiac septal defect 18.68 11.65 33 402789 927 42217586
Osteoporotic fracture 18.68 11.65 43 402779 1468 42217045
Strongyloidiasis 18.67 11.65 73 402749 3358 42215155
Respiratory symptom 18.64 11.65 49 402773 11057 42207456
Protein-losing gastroenteropathy 18.61 11.65 22 402800 423 42218090
Injection site papule 18.60 11.65 20 402802 345 42218168
Nasal cavity cancer 18.54 11.65 16 402806 207 42218306
Acute respiratory failure 18.53 11.65 257 402565 38601 42179912
Hepatic failure 18.52 11.65 251 402571 37849 42180664
Glottis carcinoma 18.47 11.65 7 402815 13 42218500
Sudden cardiac death 18.42 11.65 7 402815 3917 42214596
Heavy chain disease 18.36 11.65 5 402817 0 42218513
Metaphyseal corner fracture 18.36 11.65 5 402817 0 42218513
Epstein-Barr virus antigen positive 18.34 11.65 9 402813 39 42218474
Atopy 18.31 11.65 33 402789 942 42217571
Cytomegalovirus gastroenteritis 18.31 11.65 19 402803 314 42218199
Spinal cord injury cervical 18.31 11.65 18 402804 278 42218235
Limbal stem cell deficiency 18.27 11.65 8 402814 25 42218488
Cerebrosclerosis 18.27 11.65 8 402814 25 42218488
Cholangitis 18.26 11.65 47 402775 10680 42207833
Extra dose administered 18.24 11.65 16 402806 5653 42212860
Tonsillar ulcer 18.23 11.65 15 402807 181 42218332
Low birth weight baby 18.22 11.65 42 402780 9913 42208600
Pulmonary alveolar haemorrhage 18.21 11.65 75 402747 14741 42203772
Ileocaecal resection 18.20 11.65 21 402801 393 42218120
Precursor T-lymphoblastic lymphoma/leukaemia 18.17 11.65 9 402813 40 42218473
Mental impairment 18.01 11.65 58 402764 12259 42206254
Hip fracture 17.96 11.65 66 402756 13406 42205107
Lymphocytic leukaemia 17.93 11.65 16 402806 217 42218296
Leukodystrophy 17.92 11.65 6 402816 6 42218507
Long QT syndrome 17.88 11.65 4 402818 3163 42215350
Anaphylactic reaction 17.86 11.65 290 402532 42453 42176060
Cerebral cavernous malformation 17.83 11.65 9 402813 42 42218471
Bone sarcoma 17.82 11.65 10 402812 60 42218453
Ammonia increased 17.78 11.65 11 402811 4648 42213865
Nocturia 17.73 11.65 57 402765 12055 42206458
Abscess intestinal 17.68 11.65 47 402775 1759 42216754
Diabetes mellitus inadequate control 17.63 11.65 80 402742 15310 42203203
Stress ulcer 17.58 11.65 17 402805 257 42218256
Meningitis chemical 17.57 11.65 11 402811 83 42218430
Bone marrow transplant rejection 17.53 11.65 16 402806 224 42218289
Tubulointerstitial nephritis 17.52 11.65 202 402620 31346 42187167
Haematochezia 17.52 11.65 697 402125 57739 42160774
Palatal disorder 17.51 11.65 15 402807 192 42218321
Poor venous access 17.47 11.65 123 402699 7129 42211384
Micrognathia 17.42 11.65 18 402804 296 42218217
Therapeutic product effect variable 17.41 11.65 4 402818 3105 42215408
Cardiac failure acute 17.39 11.65 68 402754 13565 42204948
Accident at work 17.38 11.65 32 402790 929 42217584
Mononeuropathy multiplex 17.38 11.65 23 402799 498 42218015
Pseudomonal bacteraemia 17.35 11.65 56 402766 2340 42216173
Enterovirus infection 17.33 11.65 38 402784 1255 42217258
Oral surgery 17.32 11.65 25 402797 589 42217924
Left ventricular hypertrophy 17.31 11.65 39 402783 9280 42209233
Incorrect product administration duration 17.28 11.65 18 402804 5862 42212651
Immune system disorder 17.28 11.65 107 402715 5937 42212576
Lip scab 17.25 11.65 11 402811 86 42218427
Bursitis infective staphylococcal 17.23 11.65 7 402815 17 42218496
Pain of skin 17.16 11.65 133 402689 7947 42210566
Lower gastrointestinal haemorrhage 17.16 11.65 49 402773 10759 42207754
Q fever 17.15 11.65 13 402809 138 42218375
Communication disorder 17.14 11.65 3 402819 2822 42215691
Impaired gastric emptying 17.09 11.65 10 402812 4356 42214157
Haemodynamic instability 17.08 11.65 61 402761 12496 42206017
Pulmonary embolism 17.08 11.65 940 401882 118672 42099841
Muscle strength abnormal 17.06 11.65 17 402805 267 42218246
Extradural abscess 17.05 11.65 32 402790 943 42217570
Ocular lymphoma 17.04 11.65 11 402811 88 42218425
Meningitis staphylococcal 17.04 11.65 11 402811 88 42218425
Amyloidosis 17.03 11.65 56 402766 2363 42216150
Emphysema 17.02 11.65 179 402643 11656 42206857
Oxygen saturation decreased 17.02 11.65 473 402349 64214 42154299
Dysplastic naevus syndrome 17.02 11.65 6 402816 8 42218505
Pharyngeal inflammation 17.00 11.65 26 402796 646 42217867
Sinusitis fungal 16.98 11.65 28 402794 743 42217770
Cytomegalovirus hepatitis 16.97 11.65 23 402799 510 42218003
Compartment syndrome 16.95 11.65 5 402817 3284 42215229
Toxoplasmosis 16.94 11.65 43 402779 1564 42216949
Meningoencephalitis herpetic 16.93 11.65 33 402789 1001 42217512
Cutaneous B-cell lymphoma 16.93 11.65 10 402812 67 42218446
Subcutaneous abscess 16.82 11.65 86 402736 4442 42214071
Protein urine present 16.78 11.65 18 402804 5783 42212730
Acute generalised exanthematous pustulosis 16.77 11.65 35 402787 8560 42209953
Palmoplantar pustulosis 16.74 11.65 22 402800 473 42218040
Diastolic dysfunction 16.73 11.65 25 402797 6958 42211555
Skin injury 16.72 11.65 59 402763 2582 42215931
Diffuse large B-cell lymphoma stage III 16.69 11.65 10 402812 69 42218444
Degenerative bone disease 16.58 11.65 10 402812 70 42218443
Organising pneumonia 16.57 11.65 125 402697 7407 42211106
Osteomyelitis 16.53 11.65 253 402569 17970 42200543
Malaise 16.51 11.65 1754 401068 210402 42008111
Enuresis 16.50 11.65 3 402819 2745 42215768
Lactobacillus infection 16.49 11.65 19 402803 355 42218158
Cerebral fungal infection 16.45 11.65 19 402803 356 42218157
Hemiparesis 16.45 11.65 243 402579 17133 42201380
Pericarditis constrictive 16.37 11.65 23 402799 528 42217985
Lower motor neurone lesion 16.31 11.65 9 402813 52 42218461
Muscle swelling 16.28 11.65 21 402801 443 42218070
Body temperature fluctuation 16.26 11.65 43 402779 1604 42216909
Tumour haemorrhage 16.24 11.65 7 402815 3631 42214882
Urethroscopy 16.24 11.65 6 402816 10 42218503
Acute pulmonary oedema 16.23 11.65 36 402786 8615 42209898
Inadequate analgesia 16.22 11.65 5 402817 3192 42215321
Adactyly 16.17 11.65 11 402811 97 42218416
Cyanosis 16.13 11.65 80 402742 14951 42203562
Vitreous floaters 16.12 11.65 10 402812 4220 42214293
Atypical haemolytic uraemic syndrome 16.12 11.65 23 402799 536 42217977
Neutropenia 16.11 11.65 2136 400686 197295 42021218
Stomatococcal infection 16.09 11.65 15 402807 216 42218297
Myocardial ischaemia 16.08 11.65 100 402722 17662 42200851
Post procedural inflammation 16.07 11.65 8 402814 36 42218477
Soft tissue infection 16.06 11.65 59 402763 2634 42215879
Thyroid cancer 16.05 11.65 45 402777 1738 42216775
Anal stenosis 16.01 11.65 18 402804 327 42218186
Infective myositis 15.99 11.65 11 402811 99 42218414
Diffuse alopecia 15.99 11.65 11 402811 99 42218414
Haemoglobin abnormal 15.99 11.65 14 402808 4950 42213563
Temporal lobe epilepsy 15.98 11.65 15 402807 218 42218295
Escherichia sepsis 15.97 11.65 101 402721 5646 42212867
Splenic infection fungal 15.90 11.65 11 402811 100 42218413
Autoimmune blistering disease 15.88 11.65 6 402816 11 42218502
Rash macular 15.86 11.65 94 402728 16797 42201716
Anal squamous cell carcinoma 15.85 11.65 13 402809 156 42218357
Crohn's disease 15.84 11.65 63 402759 2921 42215592
Sinusitis bacterial 15.83 11.65 23 402799 545 42217968
Gynaecomastia 15.83 11.65 63 402759 12504 42206009
Thrombosis in device 15.82 11.65 5 402817 3141 42215372
Panniculitis 15.82 11.65 51 402771 2130 42216383
Acute pulmonary histoplasmosis 15.80 11.65 14 402808 188 42218325
Dialysis 15.80 11.65 59 402763 11927 42206586
Pneumonia viral 15.75 11.65 81 402741 4193 42214320
Ankle fracture 15.75 11.65 89 402733 4777 42213736
Sebaceous adenoma 15.73 11.65 8 402814 38 42218475
Chronic actinic dermatitis 15.73 11.65 7 402815 23 42218490
Pneumonia adenoviral 15.73 11.65 19 402803 374 42218139
Ileectomy 15.72 11.65 13 402809 158 42218355
Cauda equina syndrome 15.71 11.65 31 402791 949 42217564
Scedosporium infection 15.71 11.65 41 402781 1517 42216996
Pterygium 15.71 11.65 12 402810 129 42218384
Restless legs syndrome 15.70 11.65 43 402779 9571 42208942
Anorectal disorder 15.68 11.65 36 402786 1227 42217286
Disseminated toxoplasmosis 15.68 11.65 16 402806 259 42218254
Proctocolectomy 15.63 11.65 14 402808 191 42218322
Acute myelomonocytic leukaemia 15.63 11.65 14 402808 191 42218322
Small cell lung cancer metastatic 15.61 11.65 19 402803 377 42218136
Small for dates baby 15.60 11.65 16 402806 5247 42213266
Joint space narrowing 15.57 11.65 14 402808 192 42218321
Blood beta-D-glucan increased 15.57 11.65 22 402800 508 42218005
Splenic lesion 15.55 11.65 18 402804 338 42218175
Bladder neoplasm 15.55 11.65 40 402782 1467 42217046
Rheumatoid arthritis-associated interstitial lung disease 15.55 11.65 6 402816 12 42218501
Muscular weakness 15.53 11.65 638 402184 82860 42135653
Pharyngitis 15.51 11.65 140 402682 8750 42209763
Oesophageal squamous cell carcinoma 15.50 11.65 19 402803 380 42218133
Secondary amyloidosis 15.48 11.65 12 402810 132 42218381
Meningitis 15.47 11.65 101 402721 5708 42212805
Hypovolaemic shock 15.47 11.65 37 402785 8622 42209891
Osteosarcoma 15.46 11.65 17 402805 301 42218212
Oral toxicity 15.45 11.65 5 402817 4 42218509
Bacterial myositis 15.45 11.65 5 402817 4 42218509
Gastrointestinal infection 15.45 11.65 113 402709 6630 42211883
Neonatal respiratory distress syndrome 15.44 11.65 12 402810 4501 42214012
Stomatitis haemorrhagic 15.38 11.65 11 402811 106 42218407
Staphylococcal skin infection 15.37 11.65 32 402790 1019 42217494
Encephalitis 15.36 11.65 143 402679 9015 42209498
Mood altered 15.30 11.65 51 402771 10667 42207846
Encephalitis viral 15.19 11.65 40 402782 1488 42217025
Klebsiella infection 15.19 11.65 169 402653 11163 42207350
Joint noise 15.19 11.65 31 402791 973 42217540
Lung disorder 15.16 11.65 575 402247 47348 42171165
Adenoviral haemorrhagic cystitis 15.15 11.65 22 402800 521 42217992
Retching 15.13 11.65 32 402790 7789 42210724
Nervousness 15.11 11.65 71 402751 13461 42205052
Alopecia 15.11 11.65 373 402449 28903 42189610
Anosmia 15.04 11.65 16 402806 5160 42213353
IgA nephropathy 15.00 11.65 53 402769 2321 42216192
Gastroenteritis rotavirus 14.95 11.65 17 402805 313 42218200
Bladder neck operation 14.94 11.65 5 402817 5 42218508
Yolk sac tumour site unspecified 14.94 11.65 5 402817 5 42218508
Chronic idiopathic pain syndrome 14.91 11.65 12 402810 140 42218373
Mucosal necrosis 14.91 11.65 10 402812 86 42218427
Tenosynovitis stenosans 14.89 11.65 7 402815 27 42218486
Vascular stent thrombosis 14.86 11.65 6 402816 3236 42215277
Human herpesvirus 6 encephalitis 14.85 11.65 23 402799 578 42217935
Depressive symptom 14.84 11.65 9 402813 3844 42214669
Iron deficiency anaemia 14.81 11.65 68 402754 12971 42205542
Tachypnoea 14.80 11.65 132 402690 21530 42196983
Squamous cell carcinoma of the tongue 14.76 11.65 18 402804 358 42218155
Ileus 14.73 11.65 113 402709 19026 42199487
Varicella 14.71 11.65 48 402774 2017 42216496
Product complaint 14.71 11.65 21 402801 5956 42212557
Chronic recurrent multifocal osteomyelitis 14.70 11.65 7 402815 28 42218485
Phototherapy 14.70 11.65 7 402815 28 42218485
Human herpesvirus 8 infection 14.69 11.65 39 402783 1458 42217055
Fear-related avoidance of activities 14.68 11.65 4 402818 0 42218513
Oral mucosal roughening 14.68 11.65 4 402818 0 42218513
Subclavian vein perforation 14.68 11.65 4 402818 0 42218513
Blood thyroid stimulating hormone increased 14.67 11.65 17 402805 5275 42213238
Anti-saccharomyces cerevisiae antibody 14.65 11.65 6 402816 15 42218498
Demyelinating polyneuropathy 14.63 11.65 41 402781 1583 42216930
Tinea versicolour 14.63 11.65 21 402801 492 42218021
Bursa disorder 14.62 11.65 14 402808 209 42218304
Tension headache 14.57 11.65 7 402815 3407 42215106
Fibrinous bronchitis 14.57 11.65 11 402811 116 42218397
Disseminated Bacillus Calmette-Guerin infection 14.57 11.65 16 402806 283 42218230
Drug effective for unapproved indication 14.54 11.65 110 402712 6523 42211990
Epididymitis 14.49 11.65 62 402760 2972 42215541
Systemic candida 14.48 11.65 93 402729 5226 42213287
Tendon disorder 14.48 11.65 67 402755 3322 42215191
Steroid dependence 14.47 11.65 111 402711 6611 42211902
B-cell lymphoma stage IV 14.47 11.65 9 402813 67 42218446
Thymus disorder 14.45 11.65 15 402807 248 42218265
Anuria 14.41 11.65 58 402764 11474 42207039
Distributive shock 14.40 11.65 3 402819 2493 42216020
Blood glucose abnormal 14.37 11.65 28 402794 7025 42211488
Arthroscopy 14.37 11.65 12 402810 148 42218365
Osteomyelitis salmonella 14.33 11.65 7 402815 30 42218483
Glomerulonephritis membranous 14.29 11.65 38 402784 1422 42217091
Rash morbilliform 14.26 11.65 11 402811 4142 42214371
Social avoidant behaviour 14.20 11.65 7 402815 3357 42215156
Stupor 14.18 11.65 6 402816 3147 42215366
Herpes zoster oticus 14.17 11.65 15 402807 254 42218259
Blood chloride decreased 14.16 11.65 11 402811 4128 42214385
Radiation pneumonitis 14.16 11.65 5 402817 2928 42215585
Hepatic candidiasis 14.15 11.65 9 402813 70 42218443
Ossicle disorder 14.15 11.65 7 402815 31 42218482
Dystrophic calcification 14.15 11.65 7 402815 31 42218482
Metastases to bone 14.13 11.65 82 402740 14727 42203786
Haematopoietic neoplasm 14.12 11.65 8 402814 49 42218464
Feeling abnormal 14.11 11.65 528 402294 69258 42149255
Feeling jittery 14.11 11.65 13 402809 4485 42214028
Neck mass 14.09 11.65 44 402778 1806 42216707
Generalised oedema 14.06 11.65 86 402736 15250 42203263
Campylobacter infection 14.03 11.65 37 402785 1378 42217135
Low density lipoprotein increased 14.00 11.65 18 402804 5337 42213176
Purulent pericarditis 13.98 11.65 7 402815 32 42218481
Cutaneous tuberculosis 13.97 11.65 11 402811 124 42218389
Drug clearance increased 13.97 11.65 11 402811 124 42218389
Viral mutation identified 13.96 11.65 7 402815 3324 42215189
Encephalitis cytomegalovirus 13.95 11.65 34 402788 1205 42217308
Tendon rupture 13.95 11.65 127 402695 7956 42210557
Cerebral candidiasis 13.95 11.65 9 402813 72 42218441
Allergic fungal rhinosinusitis 13.87 11.65 8 402814 51 42218462
Impulsive behaviour 13.82 11.65 3 402819 2422 42216091
Pallor 13.79 11.65 191 402631 28695 42189818
Physical disability 13.77 11.65 44 402778 1829 42216684
Myeloproliferative neoplasm 13.74 11.65 26 402796 771 42217742
Philadelphia positive acute lymphocytic leukaemia 13.74 11.65 8 402814 52 42218461
Exposure to communicable disease 13.74 11.65 13 402809 191 42218322
Intertrigo 13.73 11.65 20 402802 475 42218038
Paraesthesia 13.72 11.65 561 402261 72898 42145615
Dyspnoea at rest 13.66 11.65 12 402810 4237 42214276
Ear canal stenosis 13.65 11.65 5 402817 8 42218505
Cutaneous T-cell lymphoma stage III 13.65 11.65 7 402815 34 42218479
Encephalitis Japanese B 13.64 11.65 6 402816 19 42218494
Product preparation error 13.63 11.65 15 402807 4763 42213750
Pruritus genital 13.62 11.65 4 402818 2635 42215878
Ocular hypertension 13.59 11.65 32 402790 1109 42217404
Device difficult to use 13.59 11.65 14 402808 4582 42213931
Exophthalmos 13.59 11.65 27 402795 831 42217682
Blood immunoglobulin A decreased 13.57 11.65 24 402798 675 42217838
Loss of libido 13.56 11.65 6 402816 3064 42215449
Gingivitis ulcerative 13.56 11.65 14 402808 230 42218283
Adenocarcinoma of colon 13.55 11.65 72 402750 3775 42214738
Immune-mediated lung disease 13.53 11.65 8 402814 3465 42215048
Leukocyturia 13.49 11.65 26 402796 782 42217731
Muscle enzyme increased 13.48 11.65 16 402806 309 42218204
Sepsis 13.46 11.65 2113 400709 197221 42021292
Investigation abnormal 13.40 11.65 23 402799 631 42217882
Swollen tongue 13.38 11.65 132 402690 21099 42197414
Systemic toxicity 13.38 11.65 8 402814 55 42218458
Herpes ophthalmic 13.37 11.65 24 402798 683 42217830
Hyperuricaemia 13.35 11.65 45 402777 9379 42209134
Gastrointestinal wall thickening 13.33 11.65 43 402779 1796 42216717
Depression suicidal 13.33 11.65 7 402815 3238 42215275
Blood testosterone decreased 13.32 11.65 16 402806 4886 42213627
Arthritis reactive 13.31 11.65 17 402805 355 42218158
Meningeal thickening 13.29 11.65 5 402817 9 42218504
CSF myelin basic protein increased 13.29 11.65 5 402817 9 42218504
Aphakia 13.29 11.65 5 402817 9 42218504
Bone atrophy 13.29 11.65 5 402817 9 42218504
Cardiovascular disorder 13.29 11.65 73 402749 13292 42205221
Stomatitis necrotising 13.28 11.65 10 402812 105 42218408
Nasal septum perforation 13.27 11.65 14 402808 236 42218277
Performance status decreased 13.26 11.65 15 402807 4705 42213808
Aplastic anaemia 13.26 11.65 177 402645 12207 42206306
Spinal cord oedema 13.24 11.65 15 402807 275 42218238
Plasmacytoma 13.24 11.65 13 402809 4351 42214162
Periorbital cellulitis 13.24 11.65 17 402805 357 42218156
Skin candida 13.23 11.65 23 402799 638 42217875
Medulloblastoma recurrent 13.20 11.65 10 402812 106 42218407
Vasculitis necrotising 13.20 11.65 29 402793 959 42217554
Rocky mountain spotted fever 13.20 11.65 6 402816 21 42218492
Staphylococcal osteomyelitis 13.18 11.65 7 402815 37 42218476
Coronary artery stenosis 13.09 11.65 52 402770 10327 42208186
Salivary gland cancer 13.09 11.65 16 402806 319 42218194
Intestinal atresia 13.08 11.65 9 402813 81 42218432
Guttate psoriasis 13.07 11.65 21 402801 545 42217968
Stem cell transplant 13.07 11.65 55 402767 2617 42215896
Acute respiratory distress syndrome 13.07 11.65 375 402447 29733 42188780
Poikiloderma 13.05 11.65 16 402806 320 42218193
Incoherent 13.04 11.65 15 402807 4670 42213843
Hypotonia 13.02 11.65 46 402776 9453 42209060
Abscess sterile 12.99 11.65 6 402816 22 42218491
Troponin T increased 12.98 11.65 5 402817 2775 42215738
Antithrombin III deficiency 12.96 11.65 11 402811 139 42218374
Infective aneurysm 12.94 11.65 30 402792 1029 42217484
Astrocytoma 12.91 11.65 13 402809 207 42218306
Chimerism 12.91 11.65 14 402808 244 42218269
Capnocytophaga infection 12.89 11.65 11 402811 140 42218373
Genital ulceration 12.88 11.65 27 402795 864 42217649
Visual acuity reduced 12.86 11.65 105 402717 17445 42201068
Morphoea 12.86 11.65 14 402808 245 42218268
Blood urine present 12.85 11.65 62 402760 11671 42206842
Pericardial haemorrhage 12.84 11.65 9 402813 3560 42214953
Prostate cancer stage IV 12.84 11.65 4 402818 2536 42215977
Hand fracture 12.82 11.65 58 402764 2848 42215665
Hypernatraemia 12.82 11.65 50 402772 9982 42208531
Double stranded DNA antibody 12.79 11.65 6 402816 23 42218490
Insurance issue 12.79 11.65 12 402810 4104 42214409
Trichosporon infection 12.79 11.65 28 402794 924 42217589
Disseminated strongyloidiasis 12.78 11.65 20 402802 507 42218006
Chest expansion decreased 12.77 11.65 11 402811 142 42218371
Scrotal cancer 12.64 11.65 5 402817 11 42218502
Cyst rupture 12.64 11.65 9 402813 86 42218427
Lung adenocarcinoma stage IV 12.64 11.65 11 402811 144 42218369
Psoas abscess 12.63 11.65 26 402796 821 42217692
Respiratory rate decreased 12.63 11.65 6 402816 2939 42215574
Cerebellar syndrome 12.61 11.65 57 402765 2798 42215715
Burkitt's lymphoma 12.61 11.65 10 402812 114 42218399
Troponin I increased 12.61 11.65 7 402815 3139 42215374
Portal hypertension 12.61 11.65 83 402739 4704 42213809
Glomerulonephritis minimal lesion 12.61 11.65 23 402799 663 42217850
Central nervous system enteroviral infection 12.60 11.65 8 402814 62 42218451
Prescription drug used without a prescription 12.60 11.65 5 402817 2725 42215788
Hypomania 12.59 11.65 4 402818 2504 42216009
Actinomycosis 12.58 11.65 21 402801 563 42217950
Inflammatory myofibroblastic tumour 12.58 11.65 11 402811 145 42218368
Granulocyte count decreased 12.57 11.65 38 402784 1532 42216981
Productive cough 12.57 11.65 381 402441 51186 42167327
Subperiosteal abscess 12.56 11.65 9 402813 87 42218426
Candida test positive 12.54 11.65 19 402803 468 42218045
Wrist surgery 12.52 11.65 11 402811 146 42218367
Mediastinal mass 12.51 11.65 14 402808 253 42218260
Carotid artery stenosis 12.51 11.65 20 402802 5416 42213097
Sleep terror 12.49 11.65 6 402816 2920 42215593
Personality change due to a general medical condition 12.47 11.65 7 402815 42 42218471
Cardiac sarcoidosis 12.46 11.65 11 402811 147 42218366
Acanthosis 12.46 11.65 11 402811 147 42218366
Inguinal hernia 12.45 11.65 134 402688 8778 42209735
Wound infection 12.37 11.65 127 402695 8219 42210294
Pancreatic neoplasm 12.35 11.65 28 402794 946 42217567
Echinococciasis 12.35 11.65 5 402817 12 42218501
Lung squamous cell carcinoma stage III 12.34 11.65 7 402815 43 42218470
Ventricular septal defect 12.34 11.65 14 402808 4385 42214128
Tinea pedis 12.32 11.65 45 402777 2003 42216510
Mycobacterium avium complex infection 12.32 11.65 59 402763 2968 42215545
Gastrointestinal mucosal disorder 12.31 11.65 19 402803 476 42218037
Akinesia 12.30 11.65 4 402818 2468 42216045
Haemothorax 12.30 11.65 19 402803 5217 42213296
Injection site reaction 12.30 11.65 213 402609 15508 42203005
Vasogenic cerebral oedema 12.28 11.65 29 402793 1007 42217506
Encephalitis enteroviral 12.27 11.65 12 402810 184 42218329
Chronic hepatitis 12.27 11.65 24 402798 730 42217783
Herpes simplex viraemia 12.26 11.65 10 402812 119 42218394
Infusion site swelling 12.25 11.65 8 402814 3284 42215229
Nail disorder 12.25 11.65 49 402773 2278 42216235
Laboratory test interference 12.24 11.65 21 402801 576 42217937
Blood immunoglobulin M decreased 12.24 11.65 26 402796 840 42217673
Adenovirus test positive 12.23 11.65 9 402813 91 42218422
Job dissatisfaction 12.22 11.65 12 402810 185 42218328
Skin infection 12.17 11.65 139 402683 9241 42209272
Throat tightness 12.17 11.65 48 402774 9551 42208962
Post procedural haemorrhage 12.17 11.65 46 402776 9266 42209247
Remission not achieved 12.16 11.65 11 402811 152 42218361
Radial nerve palsy 12.15 11.65 9 402813 92 42218421
Therapy cessation 12.13 11.65 129 402693 20321 42198192
Antineutrophil cytoplasmic antibody positive 12.13 11.65 14 402808 4351 42214162
Systemic infection 12.12 11.65 19 402803 5186 42213327
Vascular access complication 12.11 11.65 17 402805 390 42218123
Atrial thrombosis 12.09 11.65 4 402818 2440 42216073
Granulomatous dermatitis 12.08 11.65 15 402807 304 42218209
Injection site pain 12.08 11.65 665 402157 57133 42161380
Hypercapnia 12.08 11.65 20 402802 5341 42213172
Supraventricular extrasystoles 12.07 11.65 12 402810 3994 42214519
Ewing's sarcoma 12.07 11.65 5 402817 13 42218500
Meningitis noninfective 12.07 11.65 5 402817 13 42218500
Palindromic rheumatism 12.07 11.65 12 402810 188 42218325
Blood pressure inadequately controlled 12.06 11.65 6 402816 2862 42215651
Solar urticaria 12.05 11.65 6 402816 27 42218486
Toxic epidermal necrolysis 12.02 11.65 179 402643 26571 42191942
Brachycephaly 11.99 11.65 9 402813 94 42218419
Trigger finger 11.99 11.65 29 402793 1023 42217490
Streptococcal infection 11.97 11.65 99 402723 6033 42212480
Chronic myeloid leukaemia 11.96 11.65 51 402771 2441 42216072
Allergic hepatitis 11.95 11.65 4 402818 4 42218509
Nasal septum ulceration 11.95 11.65 4 402818 4 42218509
Varicella post vaccine 11.95 11.65 4 402818 4 42218509
Multicentric reticulohistiocytosis 11.95 11.65 4 402818 4 42218509
Pyomyositis 11.93 11.65 14 402808 267 42218246
Hepatosplenic candidiasis 11.92 11.65 13 402809 228 42218285
Hallucinations, mixed 11.92 11.65 9 402813 3426 42215087
Duodenal ulcer haemorrhage 11.89 11.65 23 402799 5785 42212728
Bone marrow leukaemic cell infiltration 11.88 11.65 6 402816 28 42218485
Product residue present 11.86 11.65 6 402816 2835 42215678
Diffuse idiopathic skeletal hyperostosis 11.84 11.65 7 402815 47 42218466
Lymphoplasmacytoid lymphoma/immunocytoma 11.84 11.65 7 402815 47 42218466
Herpes simplex test positive 11.83 11.65 13 402809 230 42218283
Contusion 11.83 11.65 304 402518 41681 42176832
Idiopathic intracranial hypertension 11.82 11.65 25 402797 805 42217708
Pancreatic steatosis 11.82 11.65 12 402810 193 42218320
Ileal ulcer 11.82 11.65 27 402795 917 42217596
Tender joint count 11.81 11.65 5 402817 14 42218499
Ischaemic hepatitis 11.80 11.65 3 402819 2174 42216339
Oral pustule 11.79 11.65 13 402809 231 42218282
Purulent discharge 11.77 11.65 61 402761 3168 42215345
Blood culture positive 11.76 11.65 85 402737 4968 42213545
Superior mesenteric artery syndrome 11.76 11.65 9 402813 97 42218416
Mixed liver injury 11.74 11.65 15 402807 4459 42214054
Spinal disorder 11.73 11.65 79 402743 4512 42214001
Eosinophilic myocarditis 11.73 11.65 34 402788 1339 42217174
Thyroid gland abscess 11.72 11.65 8 402814 71 42218442
Nasal crusting 11.72 11.65 19 402803 497 42218016
Pneumatosis intestinalis 11.68 11.65 81 402741 4671 42213842
Wound infection bacterial 11.68 11.65 15 402807 315 42218198
Cerebral haematoma 11.67 11.65 22 402800 5588 42212925
Fine motor skill dysfunction 11.67 11.65 47 402775 2192 42216321
Psychotic symptom 11.66 11.65 4 402818 2386 42216127
Discouragement 11.66 11.65 19 402803 499 42218014

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 11402.54 11.05 43330 1350149 1477210 107718610
Drug intolerance 4241.03 11.05 12988 1380491 393524 108802296
Joint swelling 3070.13 11.05 12365 1381114 430480 108765340
Arthralgia 3062.84 11.05 18503 1374976 761129 108434691
Treatment failure 3033.06 11.05 9012 1384467 268222 108927598
Death 2900.42 11.05 2723 1390756 696146 108499674
Completed suicide 2678.66 11.05 82 1393397 242299 108953521
Lymphoproliferative disorder 2372.42 11.05 1346 1392133 5872 109189948
Drug hypersensitivity 2186.99 11.05 11393 1382086 442697 108753123
Synovitis 1912.18 11.05 7673 1385806 266419 108929401
Rheumatoid arthritis 1797.00 11.05 8010 1385469 291603 108904217
Drug abuse 1657.73 11.05 159 1393320 177252 109018568
Musculoskeletal stiffness 1641.89 11.05 7433 1386046 272389 108923431
Hypotension 1634.25 11.05 2547 1390932 521302 108674518
Constipation 1542.50 11.05 1343 1392136 356443 108839377
Therapeutic product effect incomplete 1469.96 11.05 6151 1387328 217654 108978166
Therapeutic product effect decreased 1452.57 11.05 6516 1386963 237800 108958020
Pancytopenia 1410.34 11.05 5804 1387675 203809 108992011
Dyspnoea 1377.66 11.05 8249 1385230 1098623 108097197
Contraindicated product administered 1350.90 11.05 6452 1387027 241815 108954005
Psoriasis 1343.61 11.05 4351 1389128 135642 109060178
Arthropathy 1262.00 11.05 7037 1386442 280485 108915335
Mucosal inflammation 1233.08 11.05 3313 1390166 92828 109102992
Hyponatraemia 1203.75 11.05 619 1392860 217034 108978786
Intentional overdose 1185.89 11.05 139 1393340 132362 109063458
Acute kidney injury 1136.80 11.05 4147 1389332 631283 108564537
Mouth ulceration 1110.35 11.05 2096 1391383 46042 109149778
Arthritis 1107.87 11.05 4616 1388863 162970 109032850
Hyperkalaemia 1080.46 11.05 201 1393278 135595 109060225
Bradycardia 1046.25 11.05 328 1393151 155189 109040631
Somnolence 1043.20 11.05 1329 1392150 296120 108899700
Dehydration 1030.80 11.05 1201 1392278 278310 108917510
Pain 984.65 11.05 17192 1376287 937763 108258057
Cardiac arrest 970.99 11.05 642 1392837 196111 108999709
Rhabdomyolysis 947.69 11.05 183 1393296 120218 109075602
Psoriatic arthropathy 939.49 11.05 4929 1388550 191832 109003988
Anaemia 919.45 11.05 3661 1389818 543425 108652395
Acute graft versus host disease 894.69 11.05 952 1392527 11929 109183891
Electrocardiogram QT prolonged 865.26 11.05 162 1393317 108798 109087022
Drug interaction 824.63 11.05 3372 1390107 496811 108699009
Condition aggravated 763.45 11.05 13250 1380229 721586 108474234
Leukoencephalopathy 744.44 11.05 738 1392741 8457 109187363
Alopecia 731.04 11.05 7416 1386063 357337 108838483
Red blood cell sedimentation rate abnormal 728.39 11.05 1193 1392286 23316 109172504
Cardio-respiratory arrest 727.75 11.05 274 1393205 115562 109080258
Chronic graft versus host disease 717.91 11.05 733 1392746 8724 109187096
Syncope 702.56 11.05 912 1392567 201624 108994196
Sedation 696.63 11.05 46 1393433 69637 109126183
Dizziness 695.54 11.05 5548 1387931 692645 108503175
Hypoglycaemia 681.81 11.05 304 1393175 115800 109080020
Diffuse large B-cell lymphoma 679.95 11.05 918 1392561 14980 109180840
Suicide attempt 679.59 11.05 227 1393252 103167 109092653
C-reactive protein increased 679.50 11.05 4890 1388589 213029 108982791
Liver function test increased 679.21 11.05 2556 1390923 85992 109109828
Depressed level of consciousness 670.38 11.05 287 1393192 111991 109083829
Malignant neoplasm progression 669.64 11.05 726 1392753 173841 109021979
Red blood cell sedimentation rate increased 660.36 11.05 2331 1391148 75971 109119849
Lactic acidosis 641.84 11.05 186 1393293 92625 109103195
Cardiac failure congestive 640.24 11.05 575 1392904 150425 109045395
Hypokalaemia 637.49 11.05 817 1392662 181631 109014189
International normalised ratio increased 635.88 11.05 155 1393324 86617 109109203
Tremor 634.53 11.05 978 1392501 201254 108994566
Pain in extremity 634.49 11.05 9125 1384354 477993 108717827
Epstein-Barr virus associated lymphoproliferative disorder 631.33 11.05 507 1392972 4295 109191525
Epstein Barr virus positive mucocutaneous ulcer 622.44 11.05 301 1393178 866 109194954
Hallucination 620.56 11.05 250 1393229 101182 109094638
Agitation 616.71 11.05 327 1393152 112724 109083096
Pneumocystis jirovecii pneumonia 611.80 11.05 1535 1391944 41200 109154620
Hepatic enzyme increased 601.99 11.05 6438 1387041 314454 108881366
Fall 596.31 11.05 4805 1388674 598677 108597143
Stomatitis 590.25 11.05 5595 1387884 264647 108931173
Overdose 585.06 11.05 1298 1392181 232496 108963324
Drug clearance decreased 584.45 11.05 455 1393024 3667 109192153
Coma 570.14 11.05 393 1393086 117476 109078344
Gastrointestinal disorder 566.57 11.05 5085 1388394 236867 108958953
Infection 562.32 11.05 7005 1386474 355195 108840625
Swelling 562.17 11.05 6829 1386650 344212 108851608
Atrial fibrillation 548.75 11.05 1307 1392172 228335 108967485
Inflammation 529.61 11.05 4207 1389272 189031 109006789
Serotonin syndrome 526.87 11.05 63 1393416 59090 109136730
Drug reaction with eosinophilia and systemic symptoms 524.42 11.05 189 1393290 81906 109113914
Metabolic acidosis 506.25 11.05 315 1393164 99429 109096391
C-reactive protein abnormal 500.00 11.05 3069 1390410 126626 109069194
Rheumatoid nodule 498.41 11.05 908 1392571 19388 109176432
Tuberculosis 494.52 11.05 840 1392639 16934 109178886
Peripheral swelling 494.14 11.05 7488 1385991 396546 108799274
Diarrhoea 487.53 11.05 10799 1382680 1128706 108067114
Orthostatic hypotension 486.09 11.05 118 1393361 66131 109129689
Abdominal discomfort 483.03 11.05 7303 1386176 386555 108809265
Off label use 479.22 11.05 23283 1370196 1476902 107718918
Decreased appetite 474.22 11.05 3779 1389700 472067 108723753
Uveitis 470.76 11.05 921 1392558 20789 109175031
Ankylosing spondylitis 468.07 11.05 763 1392716 14849 109180971
Nasopharyngitis 467.35 11.05 7270 1386209 387091 108808729
Tachycardia 467.17 11.05 1388 1392091 225257 108970563
Osteoarthritis 460.12 11.05 3901 1389578 178722 109017098
Multiple sclerosis relapse 453.72 11.05 51 1393428 50189 109145631
Acute graft versus host disease in skin 451.47 11.05 615 1392864 10125 109185695
Gastrointestinal haemorrhage 448.51 11.05 878 1392601 164640 109031180
Epstein-Barr virus infection 427.22 11.05 812 1392667 17926 109177894
Hyperhidrosis 424.74 11.05 1095 1392384 186203 109009617
Oedema peripheral 424.39 11.05 2416 1391063 326244 108869576
Asthenia 422.43 11.05 6125 1387354 682874 108512946
Hypoxia 421.06 11.05 611 1392868 128904 109066916
Joint stiffness 420.64 11.05 1822 1391657 65421 109130399
Blood glucose increased 412.42 11.05 644 1392835 131852 109063968
Balance disorder 409.11 11.05 520 1392959 116040 109079780
Cardiac failure 408.73 11.05 1119 1392360 186507 109009313
Loss of consciousness 406.86 11.05 1199 1392280 195107 109000713
Angiocentric lymphoma 398.57 11.05 229 1393250 1028 109194792
Respiratory arrest 397.31 11.05 120 1393359 58179 109137641
Sopor 390.81 11.05 16 1393463 36530 109159290
Angioedema 383.96 11.05 404 1393075 98096 109097724
Pneumonia aspiration 382.12 11.05 279 1393200 80954 109114866
Neuroleptic malignant syndrome 381.63 11.05 10 1393469 34049 109161771
Loss of personal independence in daily activities 379.66 11.05 3208 1390271 146812 109049008
Platelet count decreased 376.36 11.05 1558 1391921 228885 108966935
Herpes zoster 375.97 11.05 2497 1390982 105882 109089938
Haemoglobin decreased 372.65 11.05 1737 1391742 246990 108948830
Toxicity to various agents 370.12 11.05 4069 1389410 476486 108719334
Hypomagnesaemia 365.67 11.05 151 1393328 60219 109135601
Aggression 365.32 11.05 144 1393335 59066 109136754
Product dose omission issue 364.28 11.05 2464 1391015 319318 108876502
Unresponsive to stimuli 363.66 11.05 174 1393305 63616 109132204
Histoplasmosis disseminated 363.02 11.05 338 1393141 3561 109192259
Nodule 362.78 11.05 1068 1392411 31563 109164257
Cognitive disorder 361.69 11.05 341 1393138 87170 109108650
Myelopathy 360.80 11.05 397 1393082 5179 109190641
Hospitalisation 360.56 11.05 786 1392693 141707 109054113
Seizure 358.36 11.05 1500 1391979 219685 108976135
Mobility decreased 355.00 11.05 4561 1388918 232861 108962959
Confusional state 352.01 11.05 3991 1389488 464689 108731131
Cardiogenic shock 349.59 11.05 142 1393337 57196 109138624
Drug ineffective for unapproved indication 349.30 11.05 2357 1391122 100481 109095339
Intentional self-injury 348.28 11.05 34 1393445 37395 109158425
Hand deformity 346.95 11.05 4245 1389234 214261 108981559
Device expulsion 346.39 11.05 9 1393470 30882 109164938
Lymphoma 338.84 11.05 771 1392708 19400 109176420
Anxiety 338.70 11.05 2751 1390728 342327 108853493
Graft versus host disease 337.45 11.05 738 1392741 18068 109177752
Systemic lupus erythematosus 337.10 11.05 4781 1388698 249557 108946263
Sinusitis 334.10 11.05 5424 1388055 291264 108904556
Joint effusion 332.43 11.05 782 1392697 20123 109175697
Posterior reversible encephalopathy syndrome 326.90 11.05 1055 1392424 32806 109163014
Rheumatoid factor positive 325.19 11.05 2800 1390679 128840 109066980
Bone marrow failure 321.07 11.05 1513 1391966 56335 109139485
Plasma cell myeloma 320.41 11.05 198 1393281 62738 109133082
Restlessness 312.33 11.05 159 1393320 56100 109139720
Suicidal ideation 311.41 11.05 437 1393042 93500 109102320
Intentional product misuse 306.68 11.05 770 1392709 132134 109063686
Therapeutic response decreased 303.74 11.05 2171 1391308 94328 109101492
Neurotoxicity 302.01 11.05 1192 1392287 41015 109154805
Pulmonary embolism 295.76 11.05 1542 1391937 212932 108982888
Arthritis bacterial 293.96 11.05 506 1392973 10314 109185506
Blood creatinine increased 292.70 11.05 1246 1392233 181643 109014177
Vomiting 290.93 11.05 8999 1384480 901676 108294144
Respiratory depression 290.20 11.05 32 1393447 31969 109163851
Drug withdrawal syndrome 288.70 11.05 63 1393416 37991 109157829
Poisoning deliberate 286.80 11.05 10 1393469 26321 109169499
Bone erosion 286.59 11.05 1252 1392227 45119 109150701
Acute myocardial infarction 286.52 11.05 381 1393098 83396 109112424
Fluid retention 285.34 11.05 467 1393012 93840 109101980
Chest pain 283.65 11.05 3202 1390277 373173 108822647
Hyperglycaemia 279.92 11.05 398 1393081 84692 109111128
Musculoskeletal disorder 278.42 11.05 769 1392710 21895 109173925
Pulmonary tuberculosis 274.45 11.05 447 1393032 8692 109187128
Blood creatine phosphokinase increased 272.36 11.05 311 1393168 72766 109123054
Knee arthroplasty 272.10 11.05 1571 1391908 63377 109132443
Vision blurred 271.68 11.05 782 1392697 128240 109067580
Foot deformity 271.26 11.05 1271 1392208 47209 109148611
Febrile neutropenia 270.87 11.05 5547 1387932 311220 108884600
Diabetic ketoacidosis 270.01 11.05 96 1393383 41962 109153858
Injection site pain 265.88 11.05 3418 1390061 174504 109021316
Tuberculin test positive 265.24 11.05 277 1393202 3391 109192429
Immunosuppression 264.83 11.05 648 1392831 17111 109178709
White blood cell count decreased 262.26 11.05 1751 1391728 227639 108968181
Dactylitis 261.79 11.05 291 1393188 3842 109191978
Dry skin 261.58 11.05 607 1392872 107046 109088774
Melaena 261.30 11.05 288 1393191 68469 109127351
Product use issue 260.54 11.05 5440 1388039 306255 108889565
Asthma 257.27 11.05 1970 1391509 248321 108947499
Extrapyramidal disorder 256.44 11.05 31 1393448 28836 109166984
Skin ulcer 255.97 11.05 1523 1391956 62122 109133698
Hallucination, visual 254.94 11.05 90 1393389 39515 109156305
Tenosynovitis 254.46 11.05 605 1392874 15678 109180142
Musculoskeletal pain 253.15 11.05 3467 1390012 179556 109016264
Blood calcium decreased 253.08 11.05 69 1393410 35776 109160044
Urinary retention 252.78 11.05 303 1393176 69380 109126440
Ventricular tachycardia 250.90 11.05 160 1393319 49849 109145971
Abnormal behaviour 250.81 11.05 89 1393390 38950 109156870
Coronary artery disease 249.30 11.05 322 1393157 71368 109124452
Myalgia 249.00 11.05 1708 1391771 220673 108975147
Chest discomfort 248.71 11.05 1234 1392245 172614 109023206
Disorientation 247.22 11.05 316 1393163 70355 109125465
Hypophosphataemia 245.59 11.05 58 1393421 33124 109162696
Neuropathy peripheral 244.89 11.05 1293 1392186 177984 109017836
Miosis 244.28 11.05 7 1393472 21976 109173844
Polyarthritis 243.51 11.05 654 1392825 18309 109177511
Venoocclusive liver disease 243.05 11.05 570 1392909 14637 109181183
Basal cell carcinoma 238.90 11.05 1167 1392312 44103 109151717
Dyskinesia 236.41 11.05 181 1393298 51265 109144555
Dyspnoea exertional 234.58 11.05 610 1392869 103450 109092370
Neutrophil count decreased 233.99 11.05 762 1392717 120179 109075641
Injection site bruising 233.33 11.05 1268 1392211 49995 109145825
Cerebrovascular accident 232.01 11.05 1336 1392143 179948 109015872
Haemophagocytic lymphohistiocytosis 231.24 11.05 898 1392581 30661 109165159
Flushing 230.76 11.05 621 1392858 104115 109091705
Ventricular fibrillation 230.47 11.05 116 1393363 41197 109154623
Blood pressure decreased 228.35 11.05 717 1392762 114374 109081446
Disturbance in attention 227.63 11.05 267 1393212 61728 109134092
Sinus bradycardia 227.37 11.05 47 1393432 29436 109166384
Graft versus host disease in gastrointestinal tract 226.29 11.05 406 1393073 8562 109187258
Sedation complication 225.64 11.05 5 1393474 19850 109175970
Cytokine release syndrome 225.22 11.05 335 1393144 69971 109125849
Myocardial infarction 224.20 11.05 1457 1392022 190626 109005194
Chronic obstructive pulmonary disease 223.72 11.05 670 1392809 108488 109087332
Blood urea increased 221.45 11.05 219 1393260 54738 109141082
Myoclonus 221.12 11.05 70 1393409 32928 109162892
Pulmonary oedema 220.89 11.05 598 1392881 100061 109095759
Psychotic disorder 219.40 11.05 191 1393288 50746 109145074
Mental status changes 219.22 11.05 389 1393090 75733 109120087
Lower respiratory tract infection 218.03 11.05 4288 1389191 238818 108957002
Hypocalcaemia 217.74 11.05 303 1393176 65063 109130757
Anti-cyclic citrullinated peptide antibody positive 213.34 11.05 3350 1390129 178634 109017186
Withdrawal syndrome 213.08 11.05 65 1393414 31315 109164505
Pemphigus 211.09 11.05 3839 1389640 210731 108985089
Juvenile idiopathic arthritis 209.87 11.05 315 1393164 5692 109190128
Enthesopathy 209.65 11.05 477 1393002 12001 109183819
Upper gastrointestinal haemorrhage 208.42 11.05 194 1393285 49902 109145918
Torsade de pointes 206.46 11.05 22 1393457 22578 109173242
Dysgeusia 204.84 11.05 354 1393125 69631 109126189
Rash maculo-papular 202.48 11.05 392 1393087 73830 109121990
Full blood count abnormal 201.96 11.05 245 1393234 55807 109140013
Palpitations 201.23 11.05 1178 1392301 158034 109037786
Acute graft versus host disease in intestine 200.30 11.05 298 1393181 5341 109190479
Disseminated tuberculosis 198.86 11.05 283 1393196 4863 109190957
Pulmonary fibrosis 197.43 11.05 2061 1391418 99981 109095839
Rheumatoid lung 197.09 11.05 257 1393222 4047 109191773
Troponin increased 196.17 11.05 65 1393414 29701 109166119
Graft versus host disease in skin 196.02 11.05 364 1393115 7890 109187930
Diverticulitis 195.86 11.05 1250 1392229 52272 109143548
Impaired healing 195.75 11.05 3526 1389953 193191 109002629
Breast cancer 195.17 11.05 982 1392497 37560 109158260
Osteoporosis 194.79 11.05 1814 1391665 85338 109110482
Injection site erythema 192.65 11.05 1924 1391555 92252 109103568
Poisoning 191.04 11.05 64 1393415 29041 109166779
Acute lymphocytic leukaemia recurrent 190.24 11.05 295 1393184 5492 109190328
Premature delivery 188.14 11.05 75 1393404 30557 109165263
Injection site reaction 187.22 11.05 1830 1391649 87240 109108580
Chronic graft versus host disease in skin 186.20 11.05 196 1393283 2423 109193397
Hypothyroidism 186.12 11.05 400 1393079 72499 109123321
Altered state of consciousness 185.15 11.05 274 1393205 57352 109138468
Joint range of motion decreased 184.29 11.05 2346 1391133 119486 109076334
Haemoptysis 183.44 11.05 390 1393089 70964 109124856
Mucocutaneous ulceration 183.32 11.05 117 1393362 658 109195162
Grip strength decreased 182.83 11.05 1676 1391803 78498 109117322
Hepatotoxicity 182.76 11.05 1397 1392082 62003 109133817
Parkinsonism 182.63 11.05 30 1393449 22157 109173663
Dystonia 181.57 11.05 50 1393429 25755 109170065
Blood potassium decreased 181.09 11.05 250 1393229 53864 109141956
Blood sodium decreased 181.00 11.05 131 1393348 38188 109157632
Blood alkaline phosphatase increased 180.46 11.05 390 1393089 70545 109125275
Lethargy 180.03 11.05 591 1392888 92985 109102835
Hypervolaemia 178.40 11.05 216 1393263 49244 109146576
Blood pressure fluctuation 176.15 11.05 1575 1391904 73249 109122571
Akathisia 174.94 11.05 10 1393469 17103 109178717
Arrhythmia 174.13 11.05 386 1393093 69189 109126631
B-cell lymphoma 171.79 11.05 317 1393162 6837 109188983
Visceral leishmaniasis 170.81 11.05 156 1393323 1600 109194220
Infective pulmonary exacerbation of cystic fibrosis 170.75 11.05 3 1393476 14768 109181052
Chemotherapeutic drug level increased 170.61 11.05 97 1393382 425 109195395
Cutaneous leishmaniasis 169.76 11.05 88 1393391 307 109195513
Cataract 168.98 11.05 1637 1391842 77848 109117972
Pericarditis 168.81 11.05 3780 1389699 215334 108980486
Paraesthesia oral 168.54 11.05 108 1393371 33563 109162257
Pulmonary hypertension 168.39 11.05 272 1393207 54948 109140872
End stage renal disease 168.16 11.05 33 1393446 21440 109174380
Circulatory collapse 167.91 11.05 176 1393303 42817 109153003
Creatinine renal clearance decreased 167.77 11.05 35 1393444 21780 109174040
Ascites 167.14 11.05 603 1392876 92205 109103615
Muscle twitching 167.06 11.05 84 1393395 29851 109165969
Eosinophilia 166.89 11.05 296 1393183 57640 109138180
Palmar-plantar erythrodysaesthesia syndrome 165.85 11.05 163 1393316 40862 109154958
Haematotoxicity 165.28 11.05 613 1392866 20469 109175351
Device dislocation 165.22 11.05 97 1393382 31607 109164213
Sacroiliitis 163.98 11.05 254 1393225 4724 109191096
Renal failure 162.24 11.05 1949 1391530 224625 108971195
Febrile bone marrow aplasia 162.14 11.05 537 1392942 16928 109178892
Joint destruction 161.80 11.05 398 1393081 10545 109185275
Hypersensitivity 161.29 11.05 6422 1387057 397576 108798244
Pulmonary mass 160.65 11.05 909 1392570 36392 109159428
Obstructive airways disorder 159.71 11.05 208 1393271 45941 109149879
Aphthous ulcer 159.42 11.05 607 1392872 20529 109175291
Wheezing 159.07 11.05 2260 1391219 252970 108942850
Sinus tachycardia 158.69 11.05 196 1393283 44297 109151523
Presyncope 158.48 11.05 231 1393248 48656 109147164
Anaphylactic shock 158.03 11.05 253 1393226 51293 109144527
Acute respiratory failure 157.79 11.05 457 1393022 74803 109121017
Glossodynia 157.79 11.05 3787 1389692 218217 108977603
Muscle rigidity 157.46 11.05 53 1393426 23978 109171842
Sleep disorder due to a general medical condition 156.75 11.05 259 1393220 51853 109143967
Delusion 156.33 11.05 52 1393427 23703 109172117
Latent tuberculosis 155.58 11.05 220 1393259 3757 109192063
Haematemesis 155.37 11.05 319 1393160 58789 109137031
Wound 154.68 11.05 3959 1389520 230478 108965342
Fibromyalgia 153.65 11.05 3016 1390463 167893 109027927
Malignant melanoma 152.95 11.05 515 1392964 16376 109179444
Cystitis haemorrhagic 152.69 11.05 417 1393062 11792 109184028
Synovial cyst 152.64 11.05 400 1393079 11030 109184790
Disease progression 151.67 11.05 2162 1391317 241872 108953948
Finger deformity 151.58 11.05 820 1392659 32272 109163548
Injection site pruritus 150.85 11.05 1135 1392344 50123 109145697
Cerebral haemorrhage 150.16 11.05 376 1393103 64592 109131228
Right ventricular failure 149.15 11.05 70 1393409 25884 109169936
Paranoia 148.96 11.05 48 1393431 22326 109173494
Hepatic steatosis 148.67 11.05 1090 1392389 47741 109148079
Epstein-Barr virus infection reactivation 148.19 11.05 218 1393261 3866 109191954
Faecal calprotectin increased 148.05 11.05 287 1393192 6432 109189388
Hyperthyroidism 147.63 11.05 93 1393386 29168 109166652
Exposure during pregnancy 147.53 11.05 1372 1392107 166052 109029768
Hallucination, auditory 147.42 11.05 74 1393405 26323 109169497
Abdominal distension 146.63 11.05 1453 1392026 173650 109022170
Atrial flutter 146.42 11.05 61 1393418 24201 109171619
Interstitial lung disease 146.26 11.05 2519 1390960 136815 109059005
Product use in unapproved indication 145.16 11.05 6961 1386518 440416 108755404
Schizophrenia 145.00 11.05 47 1393432 21779 109174041
Epidermal necrosis 142.59 11.05 184 1393295 2866 109192954
Delirium 142.35 11.05 1055 1392424 133970 109061850
Mycobacterium tuberculosis complex test positive 142.34 11.05 191 1393288 3097 109192723
Substance abuse 142.18 11.05 3 1393476 12460 109183360
Haematoma 141.81 11.05 330 1393149 58146 109137674
Nightmare 140.93 11.05 169 1393310 38694 109157126
Cytomegalovirus chorioretinitis 140.92 11.05 291 1393188 6837 109188983
Aspiration 140.83 11.05 107 1393372 30426 109165394
Hypothermia 140.60 11.05 78 1393401 26224 109169596
Lymphocyte count decreased 140.47 11.05 321 1393158 56922 109138898
Neoplasm progression 140.03 11.05 386 1393093 64209 109131611
Stevens-Johnson syndrome 139.31 11.05 235 1393244 46666 109149154
Anhedonia 138.45 11.05 16 1393463 15412 109180408
Lip swelling 137.85 11.05 268 1393211 50399 109145421
Mania 137.77 11.05 45 1393434 20751 109175069
Head injury 137.75 11.05 205 1393274 42812 109153008
Fear of injection 136.99 11.05 329 1393150 8582 109187238
Haematuria 136.78 11.05 559 1392920 82446 109113374
Disease recurrence 136.74 11.05 1267 1392212 59517 109136303
Irritability 135.25 11.05 247 1393232 47562 109148258
Hospice care 134.94 11.05 5 1393474 12468 109183352
Skin plaque 134.05 11.05 407 1393072 12238 109183582
Bronchospasm 133.15 11.05 111 1393368 30128 109165692
Oral herpes 132.85 11.05 844 1392635 35236 109160584
Leukocytosis 132.77 11.05 301 1393178 53527 109142293
Hypersensitivity pneumonitis 132.39 11.05 238 1393241 5027 109190793
Full blood count decreased 131.54 11.05 126 1393353 31973 109163847
Ill-defined disorder 131.05 11.05 2738 1390741 154115 109041705
Skin lesion 129.43 11.05 1102 1392377 50529 109145291
Hepatic encephalopathy 129.08 11.05 100 1393379 28156 109167664
Blood phosphorus increased 128.19 11.05 25 1393454 16315 109179505
Hepatic fibrosis 127.45 11.05 301 1393178 7765 109188055
Demyelination 126.97 11.05 331 1393148 9098 109186722
Cytomegalovirus infection reactivation 126.53 11.05 512 1392967 17821 109177999
Hypofibrinogenaemia 126.33 11.05 157 1393322 2350 109193470
Fine motor skill dysfunction 126.23 11.05 258 1393221 6016 109189804
Depressed mood 126.20 11.05 371 1393108 60438 109135382
Epstein-Barr virus associated lymphoma 125.96 11.05 129 1393350 1541 109194279
Kidney transplant rejection 125.70 11.05 6 1393473 11981 109183839
Transient ischaemic attack 125.22 11.05 401 1393078 63581 109132239
Intentional product use issue 125.00 11.05 4047 1389432 243859 108951961
Deep vein thrombosis 124.68 11.05 1143 1392336 138744 109057076
Deformity 124.06 11.05 344 1393135 9816 109186004
Angioimmunoblastic T-cell lymphoma 123.94 11.05 86 1393393 568 109195252
Therapy non-responder 123.73 11.05 2722 1390757 154585 109041235
Swelling face 123.72 11.05 670 1392809 91651 109104169
Electrocardiogram QRS complex prolonged 123.35 11.05 11 1393468 13010 109182810
Activated partial thromboplastin time prolonged 122.99 11.05 64 1393415 22304 109173516
Contraindication to medical treatment 122.76 11.05 116 1393363 1247 109194573
Impaired work ability 122.60 11.05 657 1392822 25762 109170058
Tardive dyskinesia 122.07 11.05 14 1393465 13565 109182255
Electrolyte imbalance 121.97 11.05 173 1393306 36855 109158965
Histoplasmosis 120.96 11.05 167 1393312 2786 109193034
Mydriasis 120.93 11.05 64 1393415 22093 109173727
Hepatic enzyme abnormal 120.64 11.05 332 1393147 9431 109186389
Spondyloarthropathy 120.51 11.05 124 1393355 1490 109194330
Panniculitis 120.42 11.05 451 1393028 15131 109180689
Sensitivity to weather change 119.96 11.05 337 1393142 9691 109186129
Mucosal ulceration 119.91 11.05 149 1393330 2230 109193590
Thrombosis 119.38 11.05 839 1392640 107823 109087997
Lennox-Gastaut syndrome 118.68 11.05 64 1393415 247 109195573
Vaginal flatulence 118.53 11.05 9 1393470 12135 109183685
Infusion related reaction 118.00 11.05 5904 1387575 375258 108820562
Swollen tongue 117.65 11.05 379 1393100 59983 109135837
Chills 117.49 11.05 1691 1391788 188889 109006931
Subdural haematoma 117.43 11.05 173 1393306 36281 109159539
Extranodal marginal zone B-cell lymphoma (MALT type) 117.34 11.05 89 1393390 687 109195133
Disability 116.91 11.05 716 1392763 29507 109166313
No adverse event 116.89 11.05 505 1392974 73334 109122486
Tubulointerstitial nephritis 116.46 11.05 326 1393153 53958 109141862
Jaundice 116.10 11.05 371 1393108 58865 109136955
Blood glucose decreased 115.96 11.05 120 1393359 29368 109166452
Spinal stenosis 115.83 11.05 512 1392967 18544 109177276
Heparin-induced thrombocytopenia 115.79 11.05 7 1393472 11417 109184403
Folliculitis 115.22 11.05 2847 1390632 164806 109031014
Euglycaemic diabetic ketoacidosis 115.20 11.05 8 1393471 11615 109184205
Salivary hypersecretion 114.88 11.05 38 1393441 17383 109178437
Leukaemia recurrent 114.87 11.05 168 1393311 2963 109192857
Arthrodesis 114.78 11.05 156 1393323 2562 109193258
Mycobacterium marinum infection 114.05 11.05 87 1393392 678 109195142
Abdominal pain 113.80 11.05 5292 1388187 507697 108688123
Hypovolaemia 113.39 11.05 66 1393413 21608 109174212
Joint arthroplasty 113.06 11.05 178 1393301 3359 109192461
Atrioventricular block 112.73 11.05 36 1393443 16841 109178979
Oropharyngeal pain 112.56 11.05 2360 1391119 132916 109062904
Skin erosion 112.23 11.05 236 1393243 5618 109190202
Atrioventricular block first degree 111.10 11.05 22 1393457 14203 109181617
Caesarean section 110.83 11.05 20 1393459 13797 109182023
Pallor 110.43 11.05 354 1393125 56113 109139707
Ejection fraction decreased 109.69 11.05 218 1393261 40662 109155158
Transplant rejection 109.64 11.05 89 1393390 24478 109171342
Mycobacterium chelonae infection 109.11 11.05 162 1393317 2898 109192922
Exposure to toxic agent 108.98 11.05 16 1393463 12842 109182978
Blood bilirubin increased 108.75 11.05 539 1392940 75433 109120387
Oral mucosa erosion 108.73 11.05 144 1393335 2304 109193516
Temperature regulation disorder 108.62 11.05 16 1393463 12810 109183010
Haematocrit decreased 108.48 11.05 446 1393033 65671 109130149
Atrioventricular block complete 108.15 11.05 59 1393420 20023 109175797
Transfusion 107.91 11.05 97 1393382 25375 109170445
Blood potassium increased 106.90 11.05 158 1393321 33091 109162729
Injection site warmth 106.83 11.05 469 1393010 16936 109178884
Blood pressure systolic abnormal 106.63 11.05 605 1392874 24245 109171575
Drug specific antibody present 106.41 11.05 289 1393190 8145 109187675
Acute generalised exanthematous pustulosis 106.38 11.05 71 1393408 21593 109174227
Neck pain 106.35 11.05 2160 1391319 120970 109074850
Hyperlipidaemia 106.12 11.05 180 1393299 35668 109160152
Elbow deformity 105.57 11.05 112 1393367 1398 109194422
Pulmonary arterial hypertension 105.46 11.05 154 1393325 32414 109163406
Wrist deformity 105.44 11.05 163 1393316 3026 109192794
Cardiac disorder 104.76 11.05 549 1392930 75731 109120089
Blood pressure diastolic abnormal 104.59 11.05 619 1392860 25196 109170624
Hypomania 104.26 11.05 6 1393473 10204 109185616
Eczema 104.00 11.05 512 1392967 71781 109124039
Wrong technique in product usage process 103.69 11.05 659 1392820 86689 109109131
Non-alcoholic steatohepatitis 103.64 11.05 143 1393336 2384 109193436
Rhinitis allergic 103.51 11.05 48 1393431 17874 109177946
Joint injury 103.10 11.05 859 1392620 39135 109156685
Liver disorder 102.72 11.05 2432 1391047 139811 109056009
Renal impairment 102.62 11.05 1712 1391767 186733 109009087
Dysphagia 101.79 11.05 1343 1392136 152257 109043563
Anal fistula 101.61 11.05 285 1393194 8188 109187632
Blood loss anaemia 101.46 11.05 50 1393429 17975 109177845
Exposure via skin contact 101.29 11.05 21 1393458 13126 109182694
Procedural pain 101.27 11.05 183 1393296 35382 109160438
Accidental exposure to product 100.98 11.05 309 1393170 49699 109146121
Hyperphosphataemia 100.78 11.05 40 1393439 16341 109179479
Oedema 100.64 11.05 1951 1391528 208025 108987795
Chromaturia 99.89 11.05 134 1393345 29226 109166594
Helicobacter infection 99.82 11.05 3000 1390479 178877 109016943
Abscess 99.55 11.05 640 1392839 26829 109168991
Faecaloma 99.22 11.05 32 1393447 14876 109180944
Urinary tract infection 98.73 11.05 3245 1390234 323037 108872783
Injection site haemorrhage 98.69 11.05 734 1392745 32294 109163526
Shock 98.60 11.05 345 1393134 53243 109142577
Cutaneous T-cell lymphoma 98.22 11.05 163 1393316 3221 109192599
Treatment noncompliance 97.64 11.05 530 1392949 72460 109123360
Acidosis 97.62 11.05 84 1393395 22447 109173373
Glycosylated haemoglobin increased 97.62 11.05 92 1393387 23527 109172293
Ischaemic stroke 97.55 11.05 236 1393243 41027 109154793
Speech disorder 97.50 11.05 421 1393058 61148 109134672
Myocarditis 97.44 11.05 142 1393337 29913 109165907
Pruritus 97.38 11.05 6169 1387310 575391 108620429
Gastrooesophageal reflux disease 97.37 11.05 1637 1391842 178339 109017481
Discomfort 97.32 11.05 3462 1390017 211245 108984575
Irritable bowel syndrome 97.07 11.05 2734 1390745 161481 109034339
Dysuria 96.52 11.05 410 1393069 59821 109135999
Rectal haemorrhage 96.33 11.05 1004 1392475 118829 109076991
Respiratory distress 96.10 11.05 493 1392986 68381 109127439
Dermatitis atopic 95.92 11.05 108 1393371 25433 109170387
Foot operation 95.70 11.05 254 1393225 7059 109188761
Electrocardiogram abnormal 95.03 11.05 59 1393420 18650 109177170
Haemorrhage 94.54 11.05 873 1392606 105819 109090001
Emotional distress 94.24 11.05 272 1393207 44575 109151245
Psoriasis area severity index increased 94.22 11.05 54 1393425 241 109195579
Pulmonary toxicity 94.00 11.05 458 1393021 17288 109178532
Chronic kidney disease 93.97 11.05 569 1392910 75722 109120098
Ventricular extrasystoles 93.80 11.05 88 1393391 22553 109173267
Rheumatoid factor negative 93.69 11.05 98 1393381 1202 109194618
Respiratory acidosis 93.23 11.05 29 1393450 13797 109182023
Status epilepticus 93.02 11.05 159 1393320 31412 109164408
Sleep disorder due to general medical condition, insomnia type 92.81 11.05 1858 1391621 103785 109092035
Labelled drug-drug interaction medication error 92.51 11.05 141 1393338 29161 109166659
Blood pressure systolic increased 92.42 11.05 1515 1391964 81476 109114344
Muscle spasms 92.25 11.05 2733 1390746 275424 108920396
Lymph node tuberculosis 91.96 11.05 90 1393389 1014 109194806
Urinary incontinence 90.61 11.05 311 1393168 48276 109147544
Duodenal ulcer perforation 89.82 11.05 2902 1390577 174798 109021022
Retinal pigment epitheliopathy 89.59 11.05 65 1393414 465 109195355
Foetal death 89.57 11.05 45 1393434 16000 109179820
Tachypnoea 89.48 11.05 230 1393249 39165 109156655
Injection site swelling 88.86 11.05 1179 1392300 60611 109135209
Blood magnesium decreased 88.54 11.05 73 1393406 19923 109175897
Localised infection 88.27 11.05 880 1392599 42168 109153652
Neutrophil count increased 87.73 11.05 191 1393288 34461 109161359
Diabetes mellitus inadequate control 87.68 11.05 150 1393329 29625 109166195
Hip arthroplasty 87.47 11.05 1082 1392397 54731 109141089
Inappropriate schedule of product administration 87.05 11.05 3262 1390217 200375 108995445
Red blood cell count decreased 86.91 11.05 481 1392998 65442 109130378
Myocardial ischaemia 86.58 11.05 126 1393353 26558 109169262
Cyanosis 86.51 11.05 151 1393328 29590 109166230
Scleritis 86.44 11.05 203 1393276 5217 109190603
Cytomegalovirus infection 86.43 11.05 1058 1392421 53386 109142434
Dissociation 86.37 11.05 11 1393468 9831 109185989
Heart rate increased 86.28 11.05 1283 1392196 142551 109053269
Subarachnoid haemorrhage 86.22 11.05 151 1393328 29551 109166269
Fear 86.09 11.05 99 1393380 23094 109172726
Bradypnoea 85.59 11.05 6 1393473 8643 109187177
Shoulder arthroplasty 85.57 11.05 159 1393320 3448 109192372
Device difficult to use 85.33 11.05 67 1393412 18738 109177082
Peritonitis bacterial 85.02 11.05 15 1393464 10518 109185302
Anuria 84.96 11.05 109 1393370 24232 109171588
Blood calcium increased 84.77 11.05 62 1393417 17978 109177842
Supraventricular tachycardia 84.58 11.05 110 1393369 24312 109171508
Neuroendocrine carcinoma of the skin 84.30 11.05 107 1393372 1638 109194182
Dysarthria 84.07 11.05 667 1392812 83454 109112366
Adenovirus infection 83.96 11.05 317 1393162 10677 109185143
Bone disorder 83.84 11.05 505 1392974 20687 109175133
Lung disorder 83.79 11.05 2912 1390567 177135 109018685
Arthritis infective 83.23 11.05 305 1393174 10124 109185696
Pustular psoriasis 83.04 11.05 366 1393113 13239 109182581
Respiratory failure 83.00 11.05 2071 1391408 213261 108982559
Pyoderma gangrenosum 82.92 11.05 201 1393278 5275 109190545
Foot fracture 82.84 11.05 579 1392900 24967 109170853
Acute graft versus host disease in liver 82.84 11.05 124 1393355 2235 109193585
Pleural effusion 82.79 11.05 1659 1391820 176050 109019770
Device occlusion 82.67 11.05 44 1393435 15141 109180679
Psychomotor hyperactivity 82.62 11.05 80 1393399 20197 109175623
Inflammatory marker increased 82.15 11.05 381 1393098 14088 109181732
Bradyphrenia 82.00 11.05 23 1393456 11705 109184115
Blood pressure diastolic decreased 81.71 11.05 750 1392729 35135 109160685
Bradykinesia 81.55 11.05 18 1393461 10770 109185050
Osteopenia 81.44 11.05 519 1392960 21690 109174130
Immune-mediated enterocolitis 81.14 11.05 15 1393464 10170 109185650
Venoocclusive disease 80.52 11.05 218 1393261 6132 109189688
Hepatitis B reactivation 80.38 11.05 242 1393237 7242 109188578
Atypical mycobacterial infection 80.34 11.05 132 1393347 2586 109193234
Arteriosclerosis 80.30 11.05 117 1393362 24650 109171170
Pneumonia cryptococcal 79.98 11.05 127 1393352 2415 109193405
Device leakage 79.60 11.05 52 1393427 15996 109179824
Generalised tonic-clonic seizure 79.38 11.05 386 1393093 54294 109141526
Granuloma skin 79.38 11.05 317 1393162 10966 109184854
Drug dependence 79.23 11.05 342 1393137 49678 109146142
Bundle branch block right 78.99 11.05 28 1393451 12263 109183557
Product substitution issue 78.71 11.05 105 1393374 22956 109172864
Drug therapy 78.61 11.05 3 1393476 7288 109188532
Ankle deformity 78.37 11.05 68 1393411 648 109195172
Sarcoidosis 78.00 11.05 340 1393139 12239 109183581
Haemorrhagic stroke 77.99 11.05 38 1393441 13751 109182069
Drug specific antibody 77.80 11.05 133 1393346 2695 109193125
Myasthenia gravis 77.51 11.05 94 1393385 21417 109174403
Bronchopulmonary aspergillosis allergic 77.49 11.05 8 1393471 8418 109187402
Female genital tract fistula 77.33 11.05 57 1393422 16462 109179358
Complication of device insertion 77.27 11.05 10 1393469 8828 109186992
Complications of transplanted kidney 77.16 11.05 4 1393475 7438 109188382
Chondropathy 77.10 11.05 134 1393345 2753 109193067
Bone pain 77.00 11.05 492 1392987 64641 109131179
Muscle injury 76.83 11.05 2321 1391158 138486 109057334
Secondary immunodeficiency 76.62 11.05 177 1393302 4499 109191321
Mycobacterial infection 76.60 11.05 171 1393308 4246 109191574
Bicytopenia 76.58 11.05 222 1393257 6502 109189318
Forced expiratory volume decreased 76.54 11.05 35 1393444 13141 109182679
Oral disorder 76.39 11.05 327 1393152 11676 109184144
Erythema multiforme 76.22 11.05 92 1393387 21005 109174815
Erectile dysfunction 75.85 11.05 73 1393406 18483 109177337
Inappropriate antidiuretic hormone secretion 75.84 11.05 199 1393280 33652 109162168
Faeces discoloured 75.73 11.05 200 1393279 33748 109162072
Pulseless electrical activity 75.66 11.05 60 1393419 16697 109179123
Catatonia 75.66 11.05 24 1393455 11276 109184544
Blood pressure diastolic increased 75.57 11.05 450 1393029 18357 109177463
Epistaxis 75.43 11.05 1171 1392308 129201 109066619
Arteriosclerosis coronary artery 75.39 11.05 125 1393354 24993 109170827
Multiple drug therapy 75.30 11.05 7 1393472 8007 109187813
Tricuspid valve incompetence 75.25 11.05 115 1393364 23758 109172062
Varicella zoster virus infection 75.19 11.05 213 1393266 6155 109189665
Therapy interrupted 75.09 11.05 347 1393132 49475 109146345
Asphyxia 74.77 11.05 43 1393436 14172 109181648
Adult T-cell lymphoma/leukaemia 74.64 11.05 53 1393426 365 109195455
Hodgkin's disease 74.26 11.05 70 1393409 750 109195070
Acute coronary syndrome 74.14 11.05 110 1393369 23002 109172818
Thrombotic microangiopathy 74.03 11.05 624 1392855 28525 109167295
Arachnoiditis 73.99 11.05 78 1393401 966 109194854
Gout 73.79 11.05 226 1393253 36340 109159480
Viral haemorrhagic cystitis 73.45 11.05 144 1393335 3255 109192565
Tinnitus 73.27 11.05 454 1393025 60086 109135734
Toxic epidermal necrolysis 73.10 11.05 417 1393062 56310 109139510
Depression 73.04 11.05 3260 1390219 314075 108881745
Ulcer 72.89 11.05 848 1392631 42268 109153552
Human herpesvirus 6 infection 72.76 11.05 215 1393264 6366 109189454
Sudden death 72.66 11.05 122 1393357 24273 109171547
Eye pruritus 72.42 11.05 194 1393285 32581 109163239
Ketoacidosis 72.00 11.05 19 1393460 10068 109185752
Neoplasm malignant 71.72 11.05 750 1392729 36393 109159427
Granulomatous pneumonitis 71.53 11.05 42 1393437 198 109195622
Osteoporotic fracture 71.50 11.05 187 1393292 5150 109190670
Hyperthermia 71.44 11.05 98 1393381 21174 109174646
Vaginal discharge 71.41 11.05 72 1393407 17836 109177984
Metastases to bone 71.38 11.05 183 1393296 31189 109164631
Cerebral infarction 71.23 11.05 373 1393106 51465 109144355
Polyuria 71.10 11.05 71 1393408 17667 109178153
Tenderness 71.01 11.05 623 1392856 28814 109167006
Pleurisy 70.98 11.05 322 1393157 11794 109184026
Complication associated with device 70.98 11.05 89 1393390 19984 109175836
Limb deformity 70.64 11.05 150 1393329 3596 109192224
Mesenteritis 70.57 11.05 49 1393430 324 109195496
Glaucoma 70.48 11.05 506 1392973 22011 109173809
Herpes simplex 70.43 11.05 388 1393091 15376 109180444
Pollakiuria 70.10 11.05 302 1393177 43893 109151927
Pneumonia legionella 69.73 11.05 145 1393334 3424 109192396
Benign prostatic hyperplasia 69.69 11.05 76 1393403 18158 109177662
Gait disturbance 69.61 11.05 4226 1389253 273982 108921838
Glioma 69.54 11.05 70 1393409 818 109195002
Aortic stenosis 69.41 11.05 39 1393440 13020 109182800
Skin cancer 69.22 11.05 422 1393057 17362 109178458
Pemphigoid 69.04 11.05 88 1393391 19619 109176201
Complications of bone marrow transplant 69.03 11.05 61 1393418 597 109195223
Haemorrhage intracranial 69.03 11.05 165 1393314 28804 109167016
Apparent death 68.94 11.05 128 1393351 2774 109193046
Thrombocytopenia 68.94 11.05 3642 1389837 345243 108850577
SLE arthritis 68.72 11.05 60 1393419 577 109195243
Bronchitis 68.68 11.05 2522 1390957 154510 109041310
Flatulence 68.47 11.05 381 1393098 51768 109144052
Infusion site pain 68.36 11.05 71 1393408 17348 109178472
Dialysis 68.32 11.05 88 1393391 19531 109176289
Disability assessment scale score increased 68.18 11.05 160 1393319 4110 109191710
Cardiac failure chronic 68.17 11.05 45 1393434 13766 109182054
Proteinuria 68.14 11.05 266 1393213 39752 109156068
Lung adenocarcinoma 68.03 11.05 269 1393210 9262 109186558
Gamma-glutamyltransferase increased 68.01 11.05 472 1393007 60837 109134983
Blood parathyroid hormone decreased 67.33 11.05 335 1393144 12754 109183066
Fungal infection 67.18 11.05 955 1392524 49851 109145969
Body height below normal 66.79 11.05 105 1393374 1979 109193841
Cardiac failure acute 66.68 11.05 126 1393353 23952 109171868
Dementia 66.62 11.05 192 1393287 31481 109164339
Anal abscess 66.48 11.05 307 1393172 11331 109184489
Hypoxic-ischaemic encephalopathy 66.39 11.05 15 1393464 8832 109186988
Infusion site erythema 66.07 11.05 34 1393445 11925 109183895
Squamous cell carcinoma of lung 65.93 11.05 122 1393357 2637 109193183
Hypercapnia 65.83 11.05 29 1393450 11130 109184690
Hepatitis E 65.74 11.05 162 1393317 4297 109191523
BK virus infection 65.70 11.05 333 1393146 12773 109183047
Ileus 65.58 11.05 185 1393294 30544 109165276
Oxygen saturation decreased 65.40 11.05 1492 1391987 155490 109040330
Insurance issue 65.14 11.05 26 1393453 10586 109185234
Wrong patient received product 64.99 11.05 5 1393474 6669 109189151
Extrapulmonary tuberculosis 64.91 11.05 55 1393424 506 109195314
Drug screen positive 64.75 11.05 4 1393475 6406 109189414
Cholestasis 64.73 11.05 511 1392968 64007 109131813
Tonsillitis 64.54 11.05 239 1393240 7974 109187846
Body temperature decreased 64.48 11.05 731 1392748 36204 109159616
Pharyngeal ulceration 64.42 11.05 82 1393397 1259 109194561
Investigation abnormal 64.30 11.05 113 1393366 2343 109193477
Joint ankylosis 64.23 11.05 114 1393365 2383 109193437
Thinking abnormal 63.72 11.05 58 1393421 15082 109180738
Shock haemorrhagic 63.50 11.05 157 1393322 27090 109168730
Retching 63.43 11.05 118 1393361 22564 109173256
Hiccups 63.42 11.05 42 1393437 12827 109182993
Cancer pain 63.40 11.05 6 1393473 6766 109189054
Drug dose omission by device 63.03 11.05 54 1393425 14462 109181358
Hepatic cirrhosis 62.98 11.05 1200 1392279 66426 109129394
Food allergy 62.96 11.05 96 1393383 19852 109175968
Axial spondyloarthritis 62.94 11.05 66 1393413 812 109195008
Ureaplasma infection 62.68 11.05 87 1393392 1459 109194361
Superior sagittal sinus thrombosis 62.63 11.05 75 1393404 1078 109194742
Stress fracture 62.60 11.05 217 1393262 7004 109188816
Leukopenia 62.51 11.05 2379 1391100 146412 109049408
Tibia fracture 62.50 11.05 204 1393275 6381 109189439
Neutropenia 62.42 11.05 3975 1389504 370645 108825175
Long QT syndrome 62.36 11.05 8 1393471 7110 109188710
Epicondylitis 62.18 11.05 114 1393365 2446 109193374
Cholecystitis chronic 62.16 11.05 21 1393458 9479 109186341
Immune system disorder 62.14 11.05 335 1393144 13166 109182654
Systemic infection 62.03 11.05 23 1393456 9796 109186024
Brain natriuretic peptide increased 61.73 11.05 32 1393447 11177 109184643
Diffuse large B-cell lymphoma stage IV 61.71 11.05 66 1393413 832 109194988
Rheumatoid vasculitis 61.63 11.05 55 1393424 546 109195274
Mental disorder 61.57 11.05 265 1393214 38526 109157294
Thirst 61.53 11.05 112 1393367 21595 109174225
Ventricular arrhythmia 61.45 11.05 25 1393454 10062 109185758
Abnormal dreams 61.26 11.05 43 1393436 12737 109183083
Lower gastrointestinal haemorrhage 61.25 11.05 86 1393393 18400 109177420
Product administration interrupted 61.07 11.05 33 1393446 11259 109184561
Sickle cell anaemia with crisis 60.90 11.05 22 1393457 9523 109186297
White blood cell count increased 60.81 11.05 856 1392623 95986 109099834
Granuloma 60.76 11.05 259 1393220 9231 109186589
Mycobacterium haemophilum infection 60.61 11.05 59 1393420 660 109195160
Lung neoplasm malignant 60.54 11.05 673 1392806 33169 109162651
Premature labour 60.49 11.05 20 1393459 9152 109186668
Gastric disorder 60.43 11.05 665 1392814 32692 109163128
Mitral valve incompetence 60.36 11.05 216 1393263 33113 109162707
Hyperreflexia 60.29 11.05 22 1393457 9463 109186357
Behaviour disorder 60.27 11.05 23 1393456 9624 109186196
Conjunctivitis allergic 60.21 11.05 8 1393471 6923 109188897
Blood uric acid increased 60.21 11.05 112 1393367 21417 109174403
Product preparation error 60.00 11.05 31 1393448 10848 109184972
Dust allergy 59.86 11.05 4 1393475 5997 109189823
Product administration error 59.84 11.05 253 1393226 36964 109158856
Device use error 59.63 11.05 20 1393459 9069 109186751
Inflammatory pain 59.41 11.05 85 1393394 1468 109194352
Iritis 59.28 11.05 160 1393319 4492 109191328
Infective tenosynovitis 59.27 11.05 50 1393429 457 109195363
Kounis syndrome 58.95 11.05 4 1393475 5921 109189899
Intracranial hypotension 58.81 11.05 55 1393424 583 109195237
Myelitis 58.68 11.05 127 1393352 3086 109192734
Face oedema 58.58 11.05 220 1393259 33249 109162571
Ophthalmic herpes zoster 58.39 11.05 131 1393348 3264 109192556
Pulmonary vasculitis 58.38 11.05 7 1393472 6553 109189267
Blood lactic acid increased 58.22 11.05 68 1393411 15753 109180067
Granulomatosis with polyangiitis 58.17 11.05 133 1393346 3357 109192463
Dysstasia 58.11 11.05 654 1392825 32332 109163488
Hypophagia 57.96 11.05 406 1393073 52220 109143600
Musculoskeletal deformity 57.95 11.05 84 1393395 1469 109194351
Pharyngitis 57.88 11.05 526 1392953 24572 109171248
Joint space narrowing 57.76 11.05 62 1393417 785 109195035
Glomerular filtration rate decreased 57.69 11.05 180 1393299 28776 109167044
Rheumatoid factor increased 57.65 11.05 109 1393370 2396 109193424
Prothrombin time prolonged 57.49 11.05 80 1393399 17181 109178639
Oral mucosal exfoliation 57.46 11.05 86 1393393 1550 109194270
Drug tolerance decreased 57.44 11.05 565 1392914 26975 109168845
Spinal pain 57.33 11.05 415 1393064 18100 109177720
Atrioventricular block second degree 57.28 11.05 16 1393463 8165 109187655
Erythrodermic psoriasis 57.25 11.05 96 1393383 1914 109193906
Pseudostroke 57.15 11.05 34 1393445 165 109195655
Bundle branch block left 57.13 11.05 47 1393432 12841 109182979
Hypernatraemia 57.08 11.05 85 1393394 17748 109178072
Episcleritis 57.05 11.05 75 1393404 1191 109194629
Chronic graft versus host disease in intestine 57.01 11.05 56 1393423 634 109195186
Electrocardiogram ST segment elevation 56.96 11.05 22 1393457 9138 109186682
Sleep apnoea syndrome 56.72 11.05 289 1393190 40158 109155662
Somnambulism 56.59 11.05 7 1393472 6398 109189422
Vascular device infection 56.54 11.05 75 1393404 16437 109179383
Gestational diabetes 56.52 11.05 12 1393467 7377 109188443
Mood altered 56.48 11.05 115 1393364 21260 109174560
Angioimmunoblastic T-cell lymphoma stage IV 56.44 11.05 19 1393460 10 109195810
Hypoaesthesia oral 56.43 11.05 79 1393400 16923 109178897
Central nervous system lymphoma 56.37 11.05 121 1393358 2923 109192897
Surgical failure 56.15 11.05 64 1393415 870 109194950
Pancreatitis acute 56.10 11.05 487 1392992 59787 109136033
Engraftment syndrome 56.00 11.05 93 1393386 1839 109193981
Bone swelling 55.95 11.05 90 1393389 1731 109194089
Urine output decreased 55.94 11.05 103 1393376 19773 109176047
Cyst 55.93 11.05 378 1393101 16118 109179702
Weight increased 55.84 11.05 6073 1387406 413571 108782249
Proctitis 55.83 11.05 79 1393400 16848 109178972
Liver injury 55.79 11.05 2373 1391106 148040 109047780
Corneal toxicity 55.75 11.05 27 1393452 78 109195742
Jaundice cholestatic 55.70 11.05 61 1393418 14547 109181273
Vertigo 55.57 11.05 765 1392714 86105 109109715
Lyme disease 55.56 11.05 149 1393330 4167 109191653
Atrial tachycardia 55.50 11.05 23 1393456 9155 109186665
Rash erythematous 55.49 11.05 712 1392767 81120 109114700
Ischaemic cardiomyopathy 55.47 11.05 16 1393463 7995 109187825
Dermatitis psoriasiform 55.44 11.05 134 1393345 3510 109192310
Nail psoriasis 55.39 11.05 56 1393423 658 109195162
Azotaemia 55.23 11.05 29 1393450 10056 109185764
Chemotherapeutic drug level above therapeutic 55.15 11.05 29 1393450 105 109195715
Chronic sinusitis 55.03 11.05 149 1393330 24935 109170885
Leishmaniasis 55.03 11.05 48 1393431 461 109195359
Psychomotor retardation 55.00 11.05 15 1393464 7777 109188043
Gastrointestinal inflammation 54.99 11.05 251 1393228 9218 109186602
Colorectal cancer 54.86 11.05 23 1393456 9091 109186729
Toxic skin eruption 54.85 11.05 171 1393308 27344 109168476
Uterine perforation 54.65 11.05 10 1393469 6830 109188990
Anal fissure 54.49 11.05 258 1393221 9623 109186197
Ocular lymphoma 54.43 11.05 34 1393445 183 109195637
Deafness transitory 54.36 11.05 68 1393411 1025 109194795
Bone cyst 54.29 11.05 132 1393347 3471 109192349
Sleep terror 54.27 11.05 9 1393470 6601 109189219
Clonus 54.09 11.05 21 1393458 8695 109187125
Clinodactyly 54.03 11.05 19 1393460 14 109195806
Angina unstable 53.89 11.05 77 1393402 16355 109179465
Aspartate aminotransferase increased 53.85 11.05 1568 1391911 158368 109037452
Cerebral toxoplasmosis 53.77 11.05 121 1393358 3021 109192799
International normalised ratio abnormal 53.67 11.05 8 1393471 6349 109189471
Failure to thrive 53.64 11.05 55 1393424 13519 109182301
Chronic graft versus host disease in liver 53.44 11.05 62 1393417 860 109194960
Paraesthesia 53.41 11.05 2893 1390586 273628 108922192
Skin necrosis 53.31 11.05 458 1393021 21054 109174766
Cardiomegaly 53.28 11.05 188 1393291 28942 109166878
Medial tibial stress syndrome 53.21 11.05 33 1393446 175 109195645
Hepatitis cholestatic 53.11 11.05 87 1393392 17479 109178341
Priapism 52.79 11.05 6 1393473 5855 109189965
Syringe issue 52.74 11.05 27 1393452 9498 109186322
Synovectomy 52.70 11.05 36 1393443 231 109195589
Toxic leukoencephalopathy 52.55 11.05 82 1393397 1535 109194285
Antinuclear antibody positive 52.48 11.05 242 1393237 8926 109186894
Bronchitis chronic 52.36 11.05 159 1393320 4781 109191039
Heart rate decreased 52.33 11.05 1390 1392089 81366 109114454
Immobile 52.28 11.05 214 1393265 7488 109188332
Renal tubular necrosis 52.25 11.05 202 1393277 30273 109165547
Rash macular 52.24 11.05 280 1393199 38406 109157414
Ovarian hyperstimulation syndrome 52.23 11.05 4 1393475 5356 109190464
Post transplant distal limb syndrome 52.17 11.05 60 1393419 824 109194996
Insomnia 52.12 11.05 3874 1389605 356716 108839104
Acute hepatic failure 52.03 11.05 259 1393220 36209 109159611
Pre-eclampsia 51.79 11.05 22 1393457 8628 109187192
Immunodeficiency 51.73 11.05 731 1392748 38107 109157713
Hyperprolactinaemia 51.71 11.05 10 1393469 6565 109189255
Eye swelling 51.70 11.05 227 1393252 32821 109162999
Iris adhesions 51.70 11.05 52 1393427 607 109195213
Limb discomfort 51.66 11.05 762 1392717 40092 109155728
Arteriospasm coronary 51.59 11.05 25 1393454 9075 109186745
Cholelithiasis 51.52 11.05 530 1392949 62892 109132928
Joint lock 51.47 11.05 129 1393350 3459 109192361
Dizziness postural 51.42 11.05 65 1393414 14544 109181276
Hyperlactacidaemia 51.36 11.05 20 1393459 8266 109187554
Performance status decreased 51.27 11.05 14 1393465 7252 109188568
Cutaneous B-cell lymphoma 51.17 11.05 28 1393451 112 109195708
Pruritus genital 51.12 11.05 10 1393469 6512 109189308
Bone marrow oedema 51.10 11.05 95 1393384 2061 109193759
Bloody discharge 51.03 11.05 109 1393370 2624 109193196
Metabolic encephalopathy 50.70 11.05 39 1393440 11021 109184799
Human antichimeric antibody positive 50.68 11.05 84 1393395 1658 109194162
Hepatosplenic T-cell lymphoma 50.64 11.05 63 1393416 944 109194876
Hallucinations, mixed 50.64 11.05 23 1393456 8670 109187150
Ileal stenosis 50.56 11.05 121 1393358 3149 109192671
Hidradenitis 50.54 11.05 162 1393317 5018 109190802
Aplasia 50.50 11.05 215 1393264 7658 109188162
Cardiospasm 50.47 11.05 3 1393476 4964 109190856
Nasal polyps 50.47 11.05 55 1393424 13145 109182675
Anger 50.44 11.05 102 1393377 18905 109176915
Coma scale abnormal 50.34 11.05 30 1393449 9696 109186124
Bone tuberculosis 50.29 11.05 54 1393425 684 109195136
Gait inability 50.00 11.05 2149 1391330 134227 109061593
Ageusia 49.97 11.05 108 1393371 19537 109176283
Lip ulceration 49.82 11.05 109 1393370 2669 109193151
Tooth abscess 49.74 11.05 406 1393073 18383 109177437
Poor venous access 49.65 11.05 500 1392979 24022 109171798
Dermatitis acneiform 49.54 11.05 52 1393427 12643 109183177
Cross sensitivity reaction 49.40 11.05 6 1393473 5561 109190259
Iridocyclitis 49.06 11.05 165 1393314 5243 109190577
Anaemia megaloblastic 49.06 11.05 57 1393422 792 109195028
Acute myeloid leukaemia 49.05 11.05 713 1392766 37397 109158423
Myelodysplastic syndrome 48.92 11.05 703 1392776 36781 109159039
Central nervous system leukaemia 48.89 11.05 48 1393431 543 109195277
Cushingoid 48.84 11.05 283 1393196 11429 109184391
Thyroid neoplasm 48.74 11.05 120 1393359 3181 109192639
Device breakage 48.74 11.05 61 1393418 13708 109182112
Neoplasm recurrence 48.68 11.05 161 1393318 5071 109190749
JC virus infection 48.52 11.05 162 1393317 5128 109190692
Unevaluable event 48.50 11.05 494 1392985 58733 109137087
Atlantoaxial instability 48.38 11.05 36 1393443 269 109195551
Oxygen consumption increased 48.36 11.05 7 1393472 5678 109190142
Cytomegalovirus viraemia 48.19 11.05 386 1393093 17378 109178442
Tonsillar ulcer 48.09 11.05 43 1393436 428 109195392
Blood pressure inadequately controlled 48.02 11.05 18 1393461 7615 109188205
Molluscum contagiosum 48.00 11.05 49 1393430 583 109195237
Myelosuppression 48.00 11.05 1542 1391937 92798 109103022
Throat tightness 47.69 11.05 238 1393241 33251 109162569
Cytopenia 47.69 11.05 585 1392894 29531 109166289
Post procedural haemorrhage 47.67 11.05 76 1393403 15436 109180384
Hypophysitis 47.65 11.05 6 1393473 5409 109190411
Product quality issue 47.57 11.05 686 1392793 76613 109119207
Obliterative bronchiolitis 47.40 11.05 128 1393351 3595 109192225
Spinal instability 47.31 11.05 43 1393436 438 109195382
Tendonitis 47.25 11.05 520 1392959 25563 109170257
Hepatitis B virus test positive 47.24 11.05 45 1393434 489 109195331
Extra dose administered 47.22 11.05 50 1393429 12109 109183711
Product monitoring error 46.96 11.05 27 1393452 8900 109186920
Palmoplantar pustulosis 46.91 11.05 60 1393419 926 109194894
Rheumatoid arthritis-associated interstitial lung disease 46.89 11.05 35 1393444 263 109195557
Tension headache 46.58 11.05 32 1393447 9586 109186234
Blood prolactin increased 46.58 11.05 3 1393476 4639 109191181
Human bocavirus infection 46.52 11.05 64 1393415 1064 109194756
Alveolitis 46.23 11.05 142 1393337 4297 109191523
Micturition urgency 46.06 11.05 110 1393369 19210 109176610
Temporal lobe epilepsy 46.03 11.05 43 1393436 455 109195365
Epstein-Barr virus antigen positive 46.03 11.05 24 1393455 85 109195735
Dysphonia 45.97 11.05 676 1392803 75253 109120567
Cutaneous lymphoma 45.91 11.05 34 1393445 252 109195568
Clear cell renal cell carcinoma 45.91 11.05 105 1393374 2651 109193169
Total lung capacity abnormal 45.88 11.05 3 1393476 4580 109191240
Hepatitis 45.83 11.05 1472 1392007 88582 109107238
Hypotonia 45.74 11.05 80 1393399 15665 109180155
Respiration abnormal 45.72 11.05 34 1393445 9775 109186045
Squamous cell carcinoma 45.70 11.05 393 1393086 18070 109177750
Joint laxity 45.68 11.05 99 1393380 2408 109193412
Generalised oedema 45.59 11.05 215 1393264 30489 109165331
Intervertebral disc space narrowing 45.51 11.05 84 1393395 1812 109194008
Psychomotor skills impaired 45.49 11.05 16 1393463 7042 109188778
Tooth infection 45.48 11.05 454 1393025 21762 109174058
Refusal of treatment by patient 45.44 11.05 32 1393447 9462 109186358
Tongue ulceration 45.42 11.05 149 1393330 4673 109191147
Blister 45.33 11.05 3389 1390090 223987 108971833
Abortion spontaneous 45.26 11.05 250 1393229 34032 109161788
Mucosal toxicity 45.22 11.05 50 1393429 656 109195164
Cervical dysplasia 45.21 11.05 104 1393375 2636 109193184
Musculoskeletal discomfort 44.84 11.05 474 1393005 23064 109172756
Varicella zoster pneumonia 44.67 11.05 39 1393440 375 109195445
Leukoerythroblastosis 44.45 11.05 36 1393443 309 109195511
Intestinal obstruction 44.40 11.05 442 1393037 52785 109143035
Mixed liver injury 44.36 11.05 52 1393427 12027 109183793
Ileal ulcer 44.24 11.05 81 1393398 1736 109194084
Cystitis bacterial 44.19 11.05 66 1393413 1187 109194633
Lymphadenopathy 44.12 11.05 1085 1392394 62750 109133070
Joint noise 44.11 11.05 154 1393325 4989 109190831
Obsessive-compulsive disorder 44.03 11.05 18 1393461 7223 109188597
Fistula 44.02 11.05 337 1393142 14962 109180858
Amylase increased 43.75 11.05 56 1393423 12463 109183357
Pleuropericarditis 43.75 11.05 48 1393431 624 109195196
Peritoneal tuberculosis 43.46 11.05 45 1393434 545 109195275
Intervertebral disc protrusion 43.42 11.05 537 1392942 27161 109168659
Tongue oedema 43.39 11.05 25 1393454 8231 109187589
Amyotrophic lateral sclerosis 43.27 11.05 87 1393392 2004 109193816
Septic arthritis staphylococcal 43.14 11.05 55 1393424 846 109194974
Eructation 43.08 11.05 69 1393410 13988 109181832
Norovirus test positive 42.99 11.05 57 1393422 913 109194907
Epilepsy 42.98 11.05 948 1392531 99261 109096559
Swollen joint count increased 42.96 11.05 1369 1392110 82292 109113528
Seronegative arthritis 42.93 11.05 299 1393180 12878 109182942
N-terminal prohormone brain natriuretic peptide increased 42.80 11.05 12 1393467 6109 109189711
Acute pulmonary oedema 42.76 11.05 94 1393385 16902 109178918
Abscess limb 42.67 11.05 216 1393263 8281 109187539
Sputum increased 42.66 11.05 10 1393469 5741 109190079
Lung cancer metastatic 42.53 11.05 133 1393346 4065 109191755
Neuritis 42.45 11.05 20 1393459 7379 109188441
Aplasia pure red cell 42.37 11.05 35 1393444 9543 109186277
Joint warmth 42.34 11.05 86 1393393 1996 109193824
Knee deformity 42.33 11.05 73 1393406 1490 109194330
Memory impairment 42.32 11.05 2038 1391441 194906 109000914
Hypoglycaemic coma 42.30 11.05 9 1393470 5524 109190296
Inhibitory drug interaction 42.29 11.05 6 1393473 4941 109190879
Glioblastoma multiforme 42.22 11.05 71 1393408 1419 109194401
Eye infection toxoplasmal 42.21 11.05 50 1393429 710 109195110
Abdominal wall haematoma 42.16 11.05 10 1393469 5695 109190125
Plasma cell myeloma recurrent 42.02 11.05 18 1393461 7024 109188796
Blood chloride decreased 41.96 11.05 32 1393447 9083 109186737
Diplopia 41.94 11.05 332 1393147 41562 109154258
Total lung capacity increased 41.88 11.05 7 1393472 5105 109190715
Mucocutaneous leishmaniasis 41.84 11.05 42 1393437 489 109195331
Varicella 41.83 11.05 123 1393356 3632 109192188
Tuberculous pleurisy 41.81 11.05 48 1393431 658 109195162
Pericardial effusion 41.75 11.05 490 1392989 56727 109139093
Restless legs syndrome 41.73 11.05 164 1393315 24462 109171358
Hepatic failure 41.61 11.05 612 1392867 68127 109127693
Hot flush 41.35 11.05 584 1392895 65452 109130368
Disturbance in social behaviour 41.27 11.05 7 1393472 5051 109190769
Alanine aminotransferase abnormal 41.21 11.05 229 1393250 9105 109186715
Pulse absent 41.05 11.05 49 1393430 11243 109184577
Haemodynamic instability 41.01 11.05 149 1393330 22739 109173081
Synovial disorder 40.94 11.05 106 1393373 2901 109192919
Increased appetite 40.93 11.05 79 1393400 14898 109180922
Blood glucose fluctuation 40.90 11.05 23 1393456 7675 109188145
Hepatitis acute 40.77 11.05 112 1393367 18654 109177166
Liver function test abnormal 40.73 11.05 1148 1392331 67802 109128018
Breath sounds abnormal 40.66 11.05 173 1393306 25231 109170589
Rales 40.50 11.05 167 1393312 24572 109171248
Mycobacterium avium complex infection 40.45 11.05 164 1393315 5713 109190107
Cerebral haematoma 40.42 11.05 37 1393442 9595 109186225
Cutaneous tuberculosis 40.42 11.05 32 1393447 265 109195555
Rheumatic disorder 40.36 11.05 118 1393361 3473 109192347
Nasal ulcer 40.29 11.05 96 1393383 2491 109193329
Cardiomyopathy 40.26 11.05 252 1393227 33273 109162547
Incoherent 40.22 11.05 28 1393451 8330 109187490
Lupus-like syndrome 40.12 11.05 730 1392749 40062 109155758
Left ventricular dysfunction 40.10 11.05 156 1393323 23337 109172483
Respiratory tract congestion 39.99 11.05 578 1392901 30279 109165541
Abscess bacterial 39.91 11.05 54 1393425 883 109194937
Haemodialysis 39.82 11.05 104 1393375 17615 109178205
Interferon gamma release assay positive 39.82 11.05 26 1393453 153 109195667
Immune-mediated lung disease 39.78 11.05 9 1393470 5294 109190526
Nephrogenic systemic fibrosis 39.76 11.05 10 1393469 5473 109190347
Therapy cessation 39.74 11.05 367 1393112 44490 109151330
Cerebral venous thrombosis 39.39 11.05 110 1393369 3152 109192668
Embedded device 39.33 11.05 3 1393476 4030 109191790
Choking 39.32 11.05 82 1393397 15028 109180792
Stress cardiomyopathy 39.29 11.05 88 1393391 15718 109180102
Inflammatory bowel disease 39.25 11.05 188 1393291 7046 109188774
Infection reactivation 39.25 11.05 127 1393352 3954 109191866
Gastric haemorrhage 39.24 11.05 89 1393390 15826 109179994
Hyperventilation 39.20 11.05 33 1393446 8914 109186906
Hypersomnia 39.06 11.05 201 1393278 27860 109167960
Pharyngitis streptococcal 39.06 11.05 294 1393185 12983 109182837
C-reactive protein decreased 39.05 11.05 102 1393377 2807 109193013
Incorrect product administration duration 39.04 11.05 130 1393349 20368 109175452
Adverse reaction 39.01 11.05 556 1392923 29038 109166782
Palindromic rheumatism 38.98 11.05 36 1393443 375 109195445
Subdural hygroma 38.96 11.05 43 1393436 563 109195257
Organising pneumonia 38.91 11.05 310 1393169 13933 109181887
Mineral metabolism disorder 38.91 11.05 36 1393443 376 109195444
Diastolic dysfunction 38.86 11.05 60 1393419 12344 109183476
Influenza 38.84 11.05 2550 1390929 166551 109029269
Macular degeneration 38.80 11.05 141 1393338 21518 109174302
Epstein-Barr virus test positive 38.66 11.05 64 1393415 1262 109194558
Hyperuricaemia 38.54 11.05 78 1393401 14453 109181367
Colitis ischaemic 38.52 11.05 106 1393373 17644 109178176
Nasal oedema 38.45 11.05 19 1393460 6820 109189000
Vein rupture 38.44 11.05 94 1393385 2481 109193339
Mental impairment 38.21 11.05 151 1393328 22488 109173332
Non-Hodgkin's lymphoma 38.03 11.05 67 1393412 1392 109194428
Diffuse large B-cell lymphoma stage III 38.01 11.05 21 1393458 86 109195734
Wrist surgery 37.87 11.05 51 1393428 830 109194990
Personality change 37.64 11.05 50 1393429 10952 109184868
Cardioactive drug level increased 37.54 11.05 3 1393476 3879 109191941
Renal injury 37.51 11.05 116 1393363 18597 109177223
Keratitis 37.38 11.05 146 1393333 4998 109190822
Metastases to central nervous system 37.37 11.05 154 1393325 22663 109173157
Myelitis transverse 37.29 11.05 89 1393390 2312 109193508
Muscle haemorrhage 37.25 11.05 20 1393459 6849 109188971
Ear pain 37.18 11.05 906 1392573 52320 109143500
Chronic graft versus host disease oral 37.16 11.05 38 1393441 453 109195367
Cold sweat 37.15 11.05 147 1393332 21884 109173936
Blood thyroid stimulating hormone increased 37.12 11.05 61 1393418 12240 109183580
Urine ketone body present 37.12 11.05 3 1393476 3843 109191977
Malnutrition 37.08 11.05 197 1393282 27082 109168738
Invasive ductal breast carcinoma 36.99 11.05 174 1393305 6472 109189348
Spinal disorder 36.97 11.05 264 1393215 11464 109184356
High density lipoprotein decreased 36.95 11.05 13 1393466 5720 109190100
Post procedural infection 36.88 11.05 299 1393180 13510 109182310
Eye irritation 36.87 11.05 258 1393221 33194 109162626
Spinal column injury 36.84 11.05 87 1393392 2244 109193576
T-cell lymphoma 36.80 11.05 69 1393410 1507 109194313
Aspiration bone marrow abnormal 36.77 11.05 25 1393454 159 109195661
Catheter site haemorrhage 36.77 11.05 14 1393465 5866 109189954
Therapy change 36.75 11.05 43 1393436 9954 109185866
Genital haemorrhage 36.65 11.05 23 1393456 7229 109188591
Asthma-chronic obstructive pulmonary disease overlap syndrome 36.62 11.05 17 1393462 6327 109189493
Diffuse large B-cell lymphoma recurrent 36.60 11.05 167 1393312 6132 109189688
Sciatica 36.60 11.05 1468 1392011 90931 109104889
Infusion site pruritus 36.58 11.05 9 1393470 4999 109190821
Skin papilloma 36.54 11.05 178 1393301 6718 109189102
Ileocaecal resection 36.38 11.05 41 1393438 550 109195270
Skin mass 36.37 11.05 230 1393249 9586 109186234
Therapy partial responder 36.37 11.05 663 1392816 36398 109159422
Duodenal ulcer 36.32 11.05 125 1393354 19389 109176431
Cystitis viral 36.29 11.05 66 1393413 1407 109194413
Application site pain 36.25 11.05 12 1393467 5487 109190333
Blood stem cell transplant failure 36.24 11.05 45 1393434 673 109195147
Ventricular hypertrophy 36.08 11.05 22 1393457 7023 109188797
Enterovirus test positive 35.99 11.05 32 1393447 316 109195504
Lip oedema 35.87 11.05 26 1393453 7574 109188246
Ataxia 35.80 11.05 227 1393252 29881 109165939
Pneumonia 35.80 11.05 10173 1383306 866541 108329279
Lung transplant 35.80 11.05 11 1393468 5275 109190545
Ovarian neoplasm 35.59 11.05 42 1393437 594 109195226
Angina pectoris 35.53 11.05 561 1392918 61734 109134086
Anaemia macrocytic 35.52 11.05 184 1393295 7119 109188701
Self-injurious ideation 35.50 11.05 6 1393473 4340 109191480
Ovarian cancer 35.45 11.05 129 1393350 4267 109191553
Feeling hot 35.41 11.05 875 1392604 90231 109105589
Distributive shock 35.38 11.05 15 1393464 5889 109189931
Lipodystrophy acquired 35.33 11.05 7 1393472 4517 109191303
Osteomyelitis 35.30 11.05 653 1392826 35947 109159873
Squamous cell carcinoma of the oral cavity 35.25 11.05 45 1393434 693 109195127
Encephalitis 35.24 11.05 378 1393101 18461 109177359
Muscle tightness 35.23 11.05 84 1393395 14678 109181142
Osteosclerosis 35.16 11.05 131 1393348 4384 109191436
Tendon disorder 35.13 11.05 202 1393277 8135 109187685
Mucormycosis 35.12 11.05 242 1393237 10386 109185434
Mucosal disorder 35.10 11.05 129 1393350 4288 109191532
Hypergammaglobulinaemia benign monoclonal 35.08 11.05 55 1393424 1034 109194786
General physical health deterioration 35.04 11.05 4759 1388720 420536 108775284
Osteonecrosis 35.02 11.05 609 1392870 33132 109162688
Second primary malignancy 34.96 11.05 365 1393114 17703 109178117
Folate deficiency 34.75 11.05 129 1393350 4309 109191511
Joint dislocation 34.73 11.05 615 1392864 33575 109162245
Graft versus host disease in liver 34.71 11.05 88 1393391 2377 109193443
Myelodysplastic syndrome transformation 34.67 11.05 47 1393432 770 109195050
Rhinorrhoea 34.60 11.05 1604 1391875 101062 109094758
Creatinine renal clearance increased 34.51 11.05 3 1393476 3622 109192198
Aspergillus infection 34.46 11.05 483 1392996 25133 109170687
Carcinoma in situ of skin 34.44 11.05 25 1393454 179 109195641
Carpal tunnel syndrome 34.43 11.05 436 1393043 22174 109173646
Systemic lupus erythematosus rash 34.42 11.05 78 1393401 1957 109193863
Cerebral venous sinus thrombosis 34.35 11.05 97 1393382 2798 109193022
Blood bicarbonate decreased 34.30 11.05 15 1393464 5782 109190038
Anaesthetic complication 34.29 11.05 3 1393476 3603 109192217
Eye disorder 34.17 11.05 533 1392946 28373 109167447
Progressive multifocal leukoencephalopathy 34.16 11.05 472 1393007 24484 109171336
Rheumatic fever 34.08 11.05 1880 1391599 120699 109075121
Enterovirus infection 34.03 11.05 94 1393385 2676 109193144
Gastrointestinal toxicity 34.02 11.05 249 1393230 10899 109184921
Erythema 33.96 11.05 3185 1390294 288262 108907558
Angioimmunoblastic T-cell lymphoma stage III 33.87 11.05 10 1393469 0 109195820
Dysphotopsia 33.87 11.05 10 1393469 0 109195820
Normochromic normocytic anaemia 33.86 11.05 71 1393408 12986 109182834
Nausea 33.81 11.05 14561 1378918 1221129 107974691
Bunion operation 33.77 11.05 50 1393429 892 109194928
Foetal exposure during pregnancy 33.73 11.05 27 1393452 7478 109188342
Extrasystoles 33.68 11.05 33 1393446 8285 109187535
Dermatomyositis 33.61 11.05 127 1393352 4279 109191541
Duodenal ulcer haemorrhage 33.57 11.05 31 1393448 8006 109187814
Viral upper respiratory tract infection 33.47 11.05 232 1393247 9976 109185844
Diarrhoea haemorrhagic 33.18 11.05 322 1393157 15317 109180503
Lipase increased 33.16 11.05 122 1393357 18550 109177270
Red blood cell sedimentation rate 33.15 11.05 142 1393337 5072 109190748
Retinal toxicity 33.12 11.05 68 1393411 1591 109194229
Borderline leprosy 33.09 11.05 16 1393463 46 109195774
International normalised ratio decreased 32.97 11.05 33 1393446 8203 109187617
Blood triglycerides increased 32.96 11.05 172 1393307 23754 109172066
Drooling 32.95 11.05 25 1393454 7114 109188706
Pseudomonal sepsis 32.92 11.05 211 1393268 8835 109186985
Ocular hypertension 32.90 11.05 85 1393394 2323 109193497
Nocturia 32.88 11.05 107 1393372 16883 109178937
Rash morbilliform 32.82 11.05 31 1393448 7920 109187900
Tender joint count increased 32.82 11.05 33 1393446 385 109195435
Pregnancy with contraceptive device 32.80 11.05 5 1393474 3902 109191918
Thrombosis in device 32.78 11.05 13 1393466 5314 109190506
Hereditary angioedema 32.72 11.05 25 1393454 7089 109188731
Sudden cardiac death 32.71 11.05 15 1393464 5622 109190198
Breast cancer stage I 32.67 11.05 27 1393452 7360 109188460
Diffuse alopecia 32.64 11.05 60 1393419 1290 109194530
Cytotoxic oedema 32.63 11.05 34 1393445 415 109195405
Erythema nodosum 32.62 11.05 168 1393311 6485 109189335
Tooth disorder 32.59 11.05 538 1392941 28971 109166849
Marginal zone lymphoma 32.49 11.05 26 1393453 219 109195601
Plantar fasciitis 32.49 11.05 139 1393340 4962 109190858
Hypovolaemic shock 32.46 11.05 86 1393393 14497 109181323
Meniscus injury 32.30 11.05 188 1393291 7605 109188215
Anaplastic large-cell lymphoma 32.26 11.05 25 1393454 200 109195620
Conduction disorder 32.24 11.05 6 1393473 4049 109191771
Sinus arrest 32.22 11.05 7 1393472 4235 109191585
Infusion site haemorrhage 32.18 11.05 9 1393470 4589 109191231
Viral mutation identified 32.16 11.05 8 1393471 4411 109191409
Myoglobin blood increased 32.11 11.05 7 1393472 4225 109191595
Acute pulmonary histoplasmosis 32.09 11.05 28 1393451 269 109195551
Incorrect disposal of product 32.08 11.05 59 1393420 1269 109194551
Growth failure 31.90 11.05 27 1393452 248 109195572
Left ventricular hypertrophy 31.90 11.05 75 1393404 13169 109182651
Post-traumatic stress disorder 31.87 11.05 22 1393457 6574 109189246
Hypochloraemia 31.86 11.05 4 1393475 3614 109192206
Bone fissure 31.82 11.05 39 1393440 575 109195245
Arterial haemorrhage 31.80 11.05 5 1393474 3814 109192006
Soft tissue swelling 31.79 11.05 69 1393410 1680 109194140
Palmoplantar keratoderma 31.78 11.05 14 1393465 5373 109190447
Nystagmus 31.69 11.05 61 1393418 11516 109184304
Infusion site swelling 31.69 11.05 47 1393432 9830 109185990
Dyspnoea at rest 31.66 11.05 35 1393444 8311 109187509
Oligohydramnios 31.57 11.05 6 1393473 3988 109191832
Limb operation 31.54 11.05 117 1393362 3907 109191913
Peripheral T-cell lymphoma unspecified 31.52 11.05 47 1393432 844 109194976
Device physical property issue 31.52 11.05 5 1393474 3789 109192031
Urine leukocyte esterase positive 31.43 11.05 5 1393474 3781 109192039
Epstein-Barr viraemia 31.42 11.05 108 1393371 3471 109192349
Hepatosplenomegaly 31.38 11.05 171 1393308 6748 109189072
Cholestatic liver injury 31.35 11.05 28 1393451 7348 109188472
Pyomyositis 31.16 11.05 43 1393436 717 109195103
Skin bacterial infection 31.13 11.05 47 1393432 854 109194966
Wheelchair user 31.10 11.05 187 1393292 7655 109188165
Transaminases increased 30.92 11.05 1031 1392448 62359 109133461
Polychondritis 30.90 11.05 48 1393431 895 109194925
Impulsive behaviour 30.87 11.05 3 1393476 3312 109192508
Ammonia increased 30.86 11.05 35 1393444 8215 109187605
Sweat gland tumour 30.63 11.05 37 1393442 537 109195283
Hypertriglyceridaemia 30.63 11.05 325 1393154 15829 109179991
Haematoma muscle 30.56 11.05 7 1393472 4083 109191737
Hip fracture 30.54 11.05 289 1393190 34862 109160958
Herpes virus infection 30.53 11.05 200 1393279 8438 109187382
Neck mass 30.42 11.05 131 1393348 4690 109191130
Respiratory symptom 30.42 11.05 92 1393387 14853 109180967
Alcohol interaction 30.39 11.05 5 1393474 3689 109192131
Nervousness 30.32 11.05 307 1393172 36544 109159276
Carotid artery occlusion 30.22 11.05 46 1393433 9519 109186301
Immunosuppressant drug level increased 30.20 11.05 64 1393415 11660 109184160
Arthritis enteropathic 30.19 11.05 32 1393447 399 109195421
Bone density abnormal 30.19 11.05 113 1393366 3790 109192030
Psychotic symptom 30.16 11.05 6 1393473 3861 109191959
Fusarium infection 30.14 11.05 90 1393389 2681 109193139
Hypertransaminasaemia 30.12 11.05 451 1393028 23804 109172016
Terminal ileitis 30.11 11.05 66 1393413 1618 109194202
Affective disorder 30.11 11.05 60 1393419 11181 109184639
Akinesia 30.09 11.05 5 1393474 3662 109192158
Viral infection 30.08 11.05 880 1392599 52259 109143561
Mitochondrial toxicity 30.05 11.05 3 1393476 3242 109192578
Cardiovascular disorder 30.03 11.05 166 1393313 22594 109173226
Methaemoglobinaemia 30.03 11.05 43 1393436 9125 109186695
Bursitis 29.99 11.05 1960 1391519 127958 109067862
Chronic recurrent multifocal osteomyelitis 29.99 11.05 17 1393462 74 109195746
Coronary artery stenosis 29.97 11.05 82 1393397 13676 109182144
Renal transplant 29.97 11.05 3 1393476 3235 109192585
Linear IgA disease 29.96 11.05 9 1393470 4380 109191440
Stupor 29.90 11.05 36 1393443 8229 109187591
Communication disorder 29.88 11.05 13 1393466 5026 109190794
Pneumatosis intestinalis 29.85 11.05 197 1393282 8332 109187488
Engraft failure 29.84 11.05 44 1393435 782 109195038
Joint tuberculosis 29.73 11.05 24 1393455 205 109195615
Feeling abnormal 29.63 11.05 1920 1391559 178791 109017029
Bone density decreased 29.60 11.05 321 1393158 15721 109180099
Rotator cuff syndrome 29.60 11.05 333 1393146 16461 109179359
Panic attack 29.59 11.05 228 1393251 28712 109167108
Compartment syndrome 29.52 11.05 19 1393460 5891 109189929
Multiple injuries 29.49 11.05 5 1393474 3609 109192211
Anion gap increased 29.49 11.05 9 1393470 4335 109191485
Bronchial carcinoma 29.44 11.05 57 1393422 1276 109194544
Secretion discharge 29.40 11.05 387 1393092 19857 109175963
Rash 29.39 11.05 11131 1382348 809833 108385987
Blood pH decreased 29.39 11.05 11 1393468 4658 109191162
Amnesia 29.36 11.05 1059 1392420 104349 109091471
Hyperkinesia 29.34 11.05 3 1393476 3181 109192639
Vascular access complication 29.31 11.05 84 1393395 2444 109193376
Meningitis aseptic 29.29 11.05 219 1393260 9651 109186169
Blood iron abnormal 29.26 11.05 61 1393418 1443 109194377
Device use issue 29.24 11.05 6 1393473 3778 109192042
Eosinophil count increased 29.22 11.05 151 1393328 20907 109174913
Neurosarcoidosis 29.21 11.05 33 1393446 444 109195376
Pulmonary arterial pressure increased 29.20 11.05 14 1393465 5113 109190707
Viral vasculitis 29.18 11.05 24 1393455 211 109195609
Growth retardation 29.17 11.05 85 1393394 2497 109193323
Unintended pregnancy 29.16 11.05 12 1393467 4796 109191024
Thyroid cancer 29.15 11.05 155 1393324 6059 109189761
Economic problem 29.07 11.05 8 1393471 4123 109191697
Meningoencephalitis herpetic 29.01 11.05 81 1393398 2321 109193499
Anosmia 28.96 11.05 72 1393407 12400 109183420
Injection site rash 28.91 11.05 435 1393044 22984 109172836
Cervix carcinoma 28.89 11.05 83 1393396 2418 109193402
Tumour haemorrhage 28.85 11.05 15 1393464 5230 109190590
Ganglioneuroma 28.83 11.05 20 1393459 132 109195688
Bradyarrhythmia 28.83 11.05 13 1393466 4921 109190899
Medical device site joint infection 28.76 11.05 32 1393447 423 109195397
Device malfunction 28.72 11.05 196 1393283 25362 109170458
Stillbirth 28.65 11.05 9 1393470 4255 109191565
Night sweats 28.57 11.05 2008 1391471 131975 109063845
Intestinal ischaemia 28.54 11.05 106 1393373 16073 109179747
Double stranded DNA antibody positive 28.51 11.05 35 1393444 517 109195303
Inability to afford medication 28.49 11.05 8 1393471 4068 109191752
Underdose 28.48 11.05 597 1392882 62957 109132863
Nephrogenic anaemia 28.45 11.05 11 1393468 4566 109191254
Prostatic specific antigen increased 28.45 11.05 73 1393406 12438 109183382
Skin exfoliation 28.33 11.05 864 1392615 86787 109109033
Traumatic lung injury 28.31 11.05 84 1393395 2493 109193327
Toe operation 28.31 11.05 48 1393431 966 109194854
Screaming 28.30 11.05 13 1393466 4868 109190952
Coronary arterial stent insertion 28.22 11.05 20 1393459 5895 109189925
Initial insomnia 28.22 11.05 55 1393424 10334 109185486
Catheterisation cardiac 28.16 11.05 22 1393457 6169 109189651
Psychiatric decompensation 28.16 11.05 19 1393460 5746 109190074
Decubitus ulcer 28.08 11.05 126 1393353 18110 109177710
Paradoxical psoriasis 28.07 11.05 34 1393445 495 109195325
Pseudopolyp 28.05 11.05 38 1393441 622 109195198
Troponin I increased 27.96 11.05 17 1393462 5435 109190385
Mass excision 27.90 11.05 29 1393450 353 109195467
Exposure to communicable disease 27.89 11.05 36 1393443 561 109195259
Vasoplegia syndrome 27.84 11.05 17 1393462 5422 109190398
Cardiac sarcoidosis 27.83 11.05 28 1393451 327 109195493
Pachymeningitis 27.79 11.05 33 1393446 470 109195350
Product complaint 27.73 11.05 87 1393392 13885 109181935
Procedural haemorrhage 27.72 11.05 17 1393462 5410 109190410
Visual impairment 27.71 11.05 1397 1392082 133031 109062789
Product prescribing error 27.71 11.05 467 1393012 50864 109144956
Pterygium 27.69 11.05 32 1393447 442 109195378
Legionella infection 27.68 11.05 46 1393433 910 109194910
Intervertebral disc degeneration 27.65 11.05 349 1393130 17736 109178084
Application site pruritus 27.56 11.05 9 1393470 4151 109191669
Oliguria 27.49 11.05 131 1393348 18526 109177294
Sensitisation 27.47 11.05 9 1393470 4142 109191678
Multiple fractures 27.46 11.05 200 1393279 8740 109187080
Meningitis tuberculous 27.44 11.05 54 1393425 1224 109194596
Electrocardiogram T wave inversion 27.37 11.05 19 1393460 5661 109190159
Anticoagulation drug level above therapeutic 27.36 11.05 12 1393467 4618 109191202
Nodal rhythm 27.36 11.05 5 1393474 3418 109192402
Cystitis 27.28 11.05 1054 1392425 64982 109130838
Genital ulceration 27.28 11.05 70 1393409 1905 109193915
Multiple-drug resistance 27.28 11.05 81 1393398 13154 109182666
Pathogen resistance 27.27 11.05 122 1393357 17550 109178270
Steatohepatitis 27.24 11.05 54 1393425 1231 109194589
Inadequate analgesia 27.22 11.05 15 1393464 5062 109190758
Short stature 27.16 11.05 49 1393430 1038 109194782
Vascular purpura 27.11 11.05 7 1393472 3764 109192056
Foetal methotrexate syndrome 27.09 11.05 8 1393471 0 109195820
Blood phosphorus decreased 27.09 11.05 34 1393445 7631 109188189
Endocarditis bacterial 27.06 11.05 66 1393413 1739 109194081
Product residue present 27.05 11.05 8 1393471 3933 109191887
Humoral immune defect 27.04 11.05 40 1393439 713 109195107
Nerve injury 27.03 11.05 229 1393250 10484 109185336
Tearfulness 26.98 11.05 32 1393447 7363 109188457
Knee operation 26.93 11.05 166 1393313 6856 109188964
Nasopharyngeal cancer 26.90 11.05 21 1393458 170 109195650
Meningitis listeria 26.88 11.05 54 1393425 1243 109194577
Total lung capacity decreased 26.80 11.05 30 1393449 7084 109188736
Antisynthetase syndrome 26.80 11.05 25 1393454 264 109195556
Protein total decreased 26.77 11.05 61 1393418 10829 109184991
Coronary artery occlusion 26.75 11.05 105 1393374 15667 109180153
Bronchial secretion retention 26.71 11.05 15 1393464 5009 109190811
Ejection fraction 26.68 11.05 3 1393476 2952 109192868
Fracture 26.67 11.05 450 1393029 24338 109171482
Granulomatous dermatitis 26.60 11.05 33 1393446 493 109195327
Encephalitis fungal 26.60 11.05 24 1393455 242 109195578
Haemolysis 26.59 11.05 104 1393375 15535 109180285
Transaminases abnormal 26.57 11.05 46 1393433 942 109194878
Bursitis infective 26.57 11.05 58 1393421 1418 109194402
Ischaemia 26.52 11.05 46 1393433 9037 109186783
Bezoar 26.46 11.05 9 1393470 4045 109191775
Radiation pneumonitis 26.43 11.05 12 1393467 4524 109191296
Antibody test positive 26.39 11.05 93 1393386 3027 109192793
Pleural fibrosis 26.37 11.05 116 1393363 4192 109191628
Hypoventilation 26.37 11.05 38 1393441 8043 109187777
Monoclonal B-cell lymphocytosis 26.37 11.05 24 1393455 245 109195575
Schizoaffective disorder 26.35 11.05 4 1393475 3132 109192688
Serum procollagen type III N-terminal propeptide increased 26.26 11.05 13 1393466 40 109195780
Sinus node dysfunction 26.25 11.05 46 1393433 9001 109186819
Lymphoedema 26.21 11.05 98 1393381 14831 109180989
Laryngospasm 26.20 11.05 13 1393466 4655 109191165
Tendon rupture 26.12 11.05 282 1393197 13796 109182024
Ependymoma malignant 26.11 11.05 11 1393468 20 109195800
Neutrophilia 26.09 11.05 57 1393422 10272 109185548
Faecal calprotectin abnormal 26.08 11.05 27 1393452 327 109195493
Depressive symptom 26.07 11.05 41 1393438 8373 109187447
Osteosarcoma recurrent 26.07 11.05 19 1393460 137 109195683
Intestinal sepsis 26.03 11.05 46 1393433 958 109194862
Extremity contracture 25.98 11.05 64 1393415 1697 109194123
Trigger finger 25.96 11.05 130 1393349 4962 109190858
Mass 25.95 11.05 369 1393110 19261 109176559
Blood glucose abnormal 25.94 11.05 80 1393399 12836 109182984
Blood sodium increased 25.93 11.05 19 1393460 5504 109190316
Bursitis infective staphylococcal 25.83 11.05 15 1393464 69 109195751
Acute lymphocytic leukaemia 25.82 11.05 142 1393337 5623 109190197
Alcohol abuse 25.80 11.05 15 1393464 4914 109190906
Congestive hepatopathy 25.77 11.05 17 1393462 5203 109190617
Coccidioidomycosis 25.77 11.05 61 1393418 1576 109194244
Urine abnormality 25.72 11.05 47 1393432 9049 109186771
Troponin T increased 25.70 11.05 11 1393468 4295 109191525
Cardiac murmur 25.67 11.05 193 1393286 24435 109171385
Visual acuity reduced 25.66 11.05 270 1393209 31903 109163917
Listeriosis 25.66 11.05 86 1393393 2728 109193092
Homicidal ideation 25.57 11.05 7 1393472 3620 109192200
Ankle operation 25.56 11.05 55 1393424 1331 109194489
Anticonvulsant drug level increased 25.56 11.05 3 1393476 2855 109192965
Q fever 25.52 11.05 25 1393454 282 109195538
Tonsil cancer 25.45 11.05 53 1393426 1253 109194567
Morphoea 25.39 11.05 35 1393444 583 109195237
Hair follicle tumour benign 25.33 11.05 30 1393449 426 109195394
Meningitis haemophilus 25.29 11.05 10 1393469 14 109195806
Sinusitis bacterial 25.29 11.05 78 1393401 2366 109193454
Enterobacter infection 25.28 11.05 142 1393337 5669 109190151
Carpal tunnel decompression 25.27 11.05 43 1393436 868 109194952
Haemorrhagic transformation stroke 25.24 11.05 4 1393475 3033 109192787
Nipple swelling 25.23 11.05 28 1393451 369 109195451
Osteonecrosis of jaw 25.22 11.05 439 1393040 47578 109148242
Disseminated sporotrichosis 25.22 11.05 14 1393465 58 109195762
Anal stenosis 25.21 11.05 35 1393444 587 109195233
Self-consciousness 25.15 11.05 21 1393458 189 109195631
Facial paralysis 25.11 11.05 437 1393042 23777 109172043
Oesophageal squamous cell carcinoma 25.11 11.05 32 1393447 492 109195328
Neutropenic colitis 25.10 11.05 181 1393298 7884 109187936
Sexual dysfunction 25.09 11.05 43 1393436 8487 109187333
Intertrigo 25.01 11.05 51 1393428 1187 109194633
Granulomatous liver disease 24.91 11.05 59 1393420 1525 109194295
Neuralgia 24.89 11.05 445 1393034 48033 109147787
Viraemia 24.77 11.05 110 1393369 3992 109191828
Haemolytic anaemia 24.74 11.05 158 1393321 20762 109175058
Craniosynostosis 24.72 11.05 15 1393464 76 109195744
Anaphylactic reaction 24.70 11.05 1182 1392297 113118 109082702
Immune effector cell-associated neurotoxicity syndrome 24.69 11.05 99 1393380 14683 109181137
Logorrhoea 24.67 11.05 16 1393463 4941 109190879
Euphoric mood 24.61 11.05 46 1393433 8781 109187039
Cerebellar tumour 24.57 11.05 20 1393459 173 109195647
Oligoarthritis 24.55 11.05 39 1393440 742 109195078
Essential hypertension 24.54 11.05 38 1393441 7809 109188011
Tongue neoplasm malignant stage unspecified 24.54 11.05 53 1393426 1286 109194534
Anticipatory anxiety 24.51 11.05 51 1393428 1205 109194615
Bronchopulmonary aspergillosis 24.50 11.05 520 1392959 29343 109166477
PCO2 decreased 24.46 11.05 5 1393474 3156 109192664
Pericardial haemorrhage 24.42 11.05 18 1393461 5199 109190621
Throat clearing 24.42 11.05 12 1393467 4321 109191499
Hepatitis fulminant 24.41 11.05 44 1393435 8516 109187304
Pulmonary arteriopathy 24.39 11.05 16 1393463 95 109195725
Pneumocystis jirovecii infection 24.35 11.05 115 1393364 4285 109191535
Catheter site erythema 24.31 11.05 24 1393455 6004 109189816
Infected dermal cyst 24.30 11.05 53 1393426 1295 109194525
Apnoea 24.30 11.05 89 1393390 13550 109182270
Pyrexia 24.23 11.05 10589 1382890 887676 108308144
Tropical infectious disease 24.22 11.05 12 1393467 37 109195783
Diverticular perforation 24.15 11.05 150 1393329 6212 109189608
Major depression 24.13 11.05 62 1393417 10559 109185261
Electrocardiogram ST segment depression 24.10 11.05 20 1393459 5441 109190379
Immune thrombocytopenia 24.06 11.05 175 1393304 22319 109173501
Ankle fracture 24.02 11.05 367 1393112 19452 109176368
Pulmonary granuloma 24 11.05 79 1393400 2482 109193338
Lupus nephritis 23.97 11.05 119 1393360 4526 109191294
Acute promyelocytic leukaemia 23.95 11.05 65 1393414 1831 109193989
Iron deficiency anaemia 23.91 11.05 268 1393211 31291 109164529
Sinus congestion 23.91 11.05 527 1392952 29932 109165888
Alcohol use 23.87 11.05 11 1393468 4111 109191709
Staphylococcal sepsis 23.84 11.05 330 1393149 17124 109178696
Small intestinal obstruction 23.84 11.05 275 1393204 31938 109163882
Catheter site infection 23.83 11.05 40 1393439 7960 109187860
Xanthogranuloma 23.83 11.05 15 1393464 82 109195738
Enterovesical fistula 23.81 11.05 55 1393424 1398 109194422
Nodular regenerative hyperplasia 23.77 11.05 59 1393420 1572 109194248
Eyelid oedema 23.77 11.05 105 1393374 15157 109180663
Ear infection 23.77 11.05 992 1392487 61740 109134080
West Nile viral infection 23.75 11.05 52 1393427 1274 109194546
Antithrombin III decreased 23.73 11.05 31 1393448 489 109195331
Osteophyte fracture 23.71 11.05 7 1393472 0 109195820
Arthritis viral 23.71 11.05 7 1393472 0 109195820
Mucositis management 23.71 11.05 7 1393472 0 109195820
Elbow operation 23.70 11.05 30 1393449 458 109195362
Chronic graft versus host disease in eye 23.67 11.05 28 1393451 397 109195423
Thrombotic thrombocytopenic purpura 23.64 11.05 33 1393446 7078 109188742
Large granular lymphocytosis 23.55 11.05 31 1393448 493 109195327
Deafness 23.53 11.05 470 1393009 26239 109169581
Supraventricular extrasystoles 23.47 11.05 41 1393438 8032 109187788
SAPHO syndrome 23.40 11.05 33 1393446 562 109195258
Spondylitis 23.35 11.05 232 1393247 11106 109184714
Laryngeal disorder 23.32 11.05 48 1393431 1125 109194695
Gastritis 23.31 11.05 507 1392972 53192 109142628
Nocardiosis 23.30 11.05 168 1393311 7318 109188502
Therapeutic product effect delayed 23.30 11.05 115 1393364 4364 109191456
Electrocardiogram T wave abnormal 23.28 11.05 12 1393467 4205 109191615
Hypertonia 23.27 11.05 44 1393435 8362 109187458
Parakeratosis 23.22 11.05 31 1393448 500 109195320
Bone abscess 23.22 11.05 36 1393443 670 109195150
Hyperthermia malignant 23.22 11.05 10 1393469 3890 109191930
Localised oedema 23.21 11.05 51 1393428 9172 109186648
Metastases to liver 23.21 11.05 310 1393169 35076 109160744
Rebound effect 23.18 11.05 287 1393192 14519 109181301
Device infusion issue 23.18 11.05 5 1393474 3040 109192780
Onychomycosis 23.17 11.05 643 1392836 37888 109157932
Rheumatoid factor 23.08 11.05 32 1393447 536 109195284
Intestinal stenosis 23.08 11.05 119 1393360 4596 109191224
Stomatitis haemorrhagic 23.03 11.05 22 1393457 240 109195580
Cytology abnormal 23.02 11.05 25 1393454 321 109195499
Application site erythema 23.01 11.05 22 1393457 5588 109190232
Staphylococcal infection 22.97 11.05 1090 1392389 68854 109126966
Autoimmune lymphoproliferative syndrome 22.95 11.05 21 1393458 216 109195604
Middle lobe syndrome 22.91 11.05 11 1393468 31 109195789
Ocular sarcoidosis 22.90 11.05 16 1393463 107 109195713
Accidental exposure to product by child 22.87 11.05 6 1393473 3192 109192628
Adverse drug reaction 22.85 11.05 1584 1391895 103975 109091845
Cartilage atrophy 22.84 11.05 19 1393460 170 109195650
Diffuse large B-cell lymphoma stage II 22.78 11.05 16 1393463 108 109195712
Immunisation 22.71 11.05 6 1393473 3177 109192643
Infectious mononucleosis 22.68 11.05 71 1393408 2171 109193649
Pulmonary cavitation 22.68 11.05 70 1393409 2124 109193696
Galactorrhoea 22.68 11.05 12 1393467 4143 109191677
Ocular hyperaemia 22.67 11.05 353 1393126 38933 109156887
Focal segmental glomerulosclerosis 22.58 11.05 12 1393467 4133 109191687
Undifferentiated connective tissue disease 22.57 11.05 21 1393458 221 109195599
Keratopathy 22.53 11.05 52 1393427 1321 109194499
Cerebrosclerosis 22.51 11.05 10 1393469 22 109195798
Haemorrhoids 22.50 11.05 315 1393164 35357 109160463
Strongyloidiasis 22.46 11.05 123 1393356 4863 109190957
Catheter site discharge 22.46 11.05 5 1393474 2974 109192846
Photosensitivity reaction 22.45 11.05 450 1393029 25139 109170681
Haemarthrosis 22.44 11.05 36 1393443 7293 109188527
Physical disability 22.36 11.05 125 1393354 4981 109190839
Catheter site pain 22.36 11.05 29 1393450 6417 109189403
Product preparation issue 22.34 11.05 4 1393475 2775 109193045
Infection in an immunocompromised host 22.31 11.05 64 1393415 1863 109193957
Testicular seminoma (pure) 22.27 11.05 18 1393461 154 109195666
Oral pain 22.27 11.05 624 1392855 36820 109159000
Cheilitis 22.27 11.05 147 1393332 6218 109189602
Taste disorder 22.26 11.05 640 1392839 64747 109131073
Lung squamous cell carcinoma recurrent 22.22 11.05 10 1393469 23 109195797
Synovial rupture 22.19 11.05 30 1393449 490 109195330
Neck deformity 22.19 11.05 63 1393416 1823 109193997
Birdshot chorioretinopathy 22.18 11.05 14 1393465 77 109195743
Metastatic bronchial carcinoma 22.18 11.05 26 1393453 365 109195455
Colon cancer 22.10 11.05 310 1393169 16133 109179687
Lacunar infarction 22.09 11.05 28 1393451 6258 109189562
Social avoidant behaviour 22.09 11.05 21 1393458 5348 109190472
Blood urine present 22.07 11.05 197 1393282 24048 109171772
Streptococcal infection 22.03 11.05 222 1393257 10668 109185152
Rash papular 22.03 11.05 232 1393247 27407 109168413
Endometrial adenocarcinoma 22.02 11.05 49 1393430 1214 109194606
Multiple sclerosis 22.02 11.05 212 1393267 25486 109170334
Intervertebral disc compression 21.93 11.05 52 1393427 1345 109194475
Type I hypersensitivity 21.93 11.05 29 1393450 6364 109189456
Gynaecomastia 21.87 11.05 55 1393424 9435 109186385
Atelectasis 21.82 11.05 328 1393151 36384 109159436
Adverse event 21.70 11.05 1622 1391857 107187 109088633
Metatarsalgia 21.70 11.05 26 1393453 374 109195446
Injection site inflammation 21.70 11.05 118 1393361 4653 109191167
Lip and/or oral cavity cancer 21.69 11.05 47 1393432 1143 109194677
Apathy 21.67 11.05 118 1393361 16121 109179699
Injection site discolouration 21.61 11.05 192 1393287 8911 109186909
Orthopnoea 21.61 11.05 69 1393410 10952 109184868
Myeloid leukaemia 21.60 11.05 40 1393439 865 109194955
Diabetic metabolic decompensation 21.57 11.05 11 1393468 3878 109191942
Haematopoietic neoplasm 21.49 11.05 14 1393465 82 109195738
Dermatitis allergic 21.44 11.05 389 1393090 21335 109174485
Tuberculosis of central nervous system 21.44 11.05 30 1393449 507 109195313
Diabetic retinopathy 21.44 11.05 9 1393470 3555 109192265
Reversible airways obstruction 21.44 11.05 3 1393476 2496 109193324
Device issue 21.41 11.05 306 1393173 34229 109161591
Pneumonia fungal 21.41 11.05 282 1393197 14472 109181348
Cytomegalovirus test positive 21.38 11.05 157 1393322 6879 109188941
Loose body in joint 21.37 11.05 52 1393427 1368 109194452
Injection site urticaria 21.34 11.05 320 1393159 16895 109178925
Acute myeloid leukaemia recurrent 21.32 11.05 124 1393355 5015 109190805
Torticollis 21.28 11.05 7 1393472 3214 109192606
Gastrointestinal pain 21.28 11.05 236 1393243 11624 109184196
Gingival ulceration 21.24 11.05 48 1393431 1202 109194618
Apoptotic colonopathy 21.18 11.05 19 1393460 190 109195630
Varicella post vaccine 21.18 11.05 8 1393471 9 109195811
Pleural thickening 21.17 11.05 92 1393387 3307 109192513
Optic ischaemic neuropathy 21.17 11.05 13 1393466 4134 109191686
HLA-B*27 positive 21.17 11.05 17 1393462 144 109195676
Premature baby 21.16 11.05 18 1393461 4837 109190983
Atrial septal defect acquired 21.12 11.05 10 1393469 27 109195793
Haemoperitoneum 21.10 11.05 22 1393457 5366 109190454
Tuberculosis gastrointestinal 21.09 11.05 32 1393447 584 109195236
Snoring 21.07 11.05 33 1393446 6751 109189069
Appendicitis 21.06 11.05 243 1393236 28221 109167599
Hepatic cytolysis 21.05 11.05 530 1392949 54523 109141297
Scleroderma renal crisis 21.04 11.05 40 1393439 883 109194937
Acanthosis 21.02 11.05 31 1393448 551 109195269
Nail disorder 21.02 11.05 912 1392567 57023 109138797
Hair colour changes 21.01 11.05 17 1393462 4684 109191136
Prosthesis user 20.95 11.05 13 1393466 69 109195751
Hepatitis B 20.93 11.05 199 1393280 9413 109186407
Productive cough 20.92 11.05 1202 1392277 113103 109082717
Pharyngeal inflammation 20.90 11.05 58 1393421 1656 109194164
Papulopustular rosacea 20.88 11.05 11 1393468 40 109195780
Crystal nephropathy 20.87 11.05 61 1393418 1795 109194025
Plasmablastic lymphoma 20.86 11.05 37 1393442 773 109195047
Respiratory rate decreased 20.85 11.05 29 1393450 6229 109189591
Subcutaneous abscess 20.84 11.05 194 1393285 9123 109186697
Ileostomy 20.84 11.05 72 1393407 2320 109193500
Retroperitoneal haematoma 20.84 11.05 28 1393451 6103 109189717
Blood thyroid stimulating hormone decreased 20.83 11.05 37 1393442 7202 109188618
Vulvovaginal erythema 20.82 11.05 29 1393450 488 109195332
Exostosis 20.79 11.05 741 1392738 45215 109150605
Corneal disorder 20.77 11.05 76 1393403 2521 109193299
Oesophageal varices haemorrhage 20.74 11.05 19 1393460 4926 109190894
CSF myelin basic protein increased 20.73 11.05 8 1393471 10 109195810
Matrix metalloproteinase-3 increased 20.73 11.05 8 1393471 10 109195810
Ankle arthroplasty 20.69 11.05 75 1393404 2476 109193344
Peritonsillar abscess 20.69 11.05 43 1393436 1015 109194805
International normalised ratio fluctuation 20.69 11.05 104 1393375 3976 109191844
Pulmonary sarcoidosis 20.66 11.05 59 1393420 1713 109194107
Drug effective for unapproved indication 20.65 11.05 271 1393208 13896 109181924
Fixed eruption 20.60 11.05 14 1393465 4218 109191602
Pericarditis tuberculous 20.60 11.05 15 1393464 108 109195712
Vasogenic cerebral oedema 20.58 11.05 69 1393410 2189 109193631
Mucosal necrosis 20.57 11.05 19 1393460 198 109195622
Tachyarrhythmia 20.53 11.05 46 1393433 8215 109187605
Herpes zoster infection neurological 20.52 11.05 29 1393450 495 109195325
Tooth fracture 20.52 11.05 255 1393224 12912 109182908
Blau syndrome 20.50 11.05 9 1393470 19 109195801
Red blood cells urine positive 20.50 11.05 21 1393458 5164 109190656
Petit mal epilepsy 20.46 11.05 40 1393439 7507 109188313
Disseminated varicella zoster virus infection 20.45 11.05 48 1393431 1233 109194587
Kidney infection 20.44 11.05 444 1393035 25155 109170665
Lymphoplasmacytoid lymphoma/immunocytoma 20.37 11.05 12 1393467 57 109195763
Graft versus host disease in eye 20.34 11.05 27 1393452 433 109195387
Hepatic steato-fibrosis 20.32 11.05 6 1393473 0 109195820
Peripheral T-cell lymphoma unspecified stage II 20.32 11.05 6 1393473 0 109195820
Empyema 20.32 11.05 130 1393349 5440 109190380
Subdural haemorrhage 20.28 11.05 32 1393447 6526 109189294
Drug level abnormal 20.19 11.05 30 1393449 537 109195283
Feeling jittery 20.19 11.05 106 1393373 14616 109181204
Burkitt's lymphoma 20.17 11.05 15 1393464 112 109195708
Product administered at inappropriate site 20.04 11.05 23 1393456 5370 109190450
Plasmacytoma 20.03 11.05 22 1393457 5240 109190580
Infiltration anaesthesia 20.01 11.05 17 1393462 157 109195663
Thymus enlargement 20.01 11.05 17 1393462 157 109195663
Peripheral T-cell lymphoma unspecified stage III 20.00 11.05 7 1393472 5 109195815
Blood creatine increased 19.99 11.05 76 1393403 11445 109184375
Dermatitis contact 19.96 11.05 99 1393380 13854 109181966
Incorrect dosage administered 19.96 11.05 100 1393379 3818 109192002
Superficial spreading melanoma stage unspecified 19.94 11.05 24 1393455 347 109195473
Intervertebral disc annular tear 19.92 11.05 11 1393468 45 109195775
Osteosarcoma metastatic 19.92 11.05 11 1393468 45 109195775
Fulminant type 1 diabetes mellitus 19.89 11.05 3 1393476 2360 109193460
Blood cholesterol increased 19.89 11.05 2639 1390840 182146 109013674
Extravasation 19.87 11.05 19 1393460 4826 109190994
Cholesteatoma 19.83 11.05 18 1393461 183 109195637
Product taste abnormal 19.82 11.05 4 1393475 2548 109193272
Tachyphrenia 19.81 11.05 3 1393476 2353 109193467
Light chain analysis increased 19.80 11.05 3 1393476 2352 109193468
Wound infection 19.75 11.05 1441 1392038 95024 109100796
Sluggishness 19.75 11.05 41 1393438 7526 109188294
Occult blood positive 19.72 11.05 40 1393439 7405 109188415
Hydronephrosis 19.66 11.05 166 1393313 20499 109175321
Brain injury 19.63 11.05 95 1393384 13381 109182439
Blood cholesterol decreased 19.61 11.05 5 1393474 2711 109193109
Postoperative wound infection 19.60 11.05 293 1393186 15460 109180360
Secondary amyloidosis 19.56 11.05 23 1393456 324 109195496
Thyroiditis 19.46 11.05 33 1393446 6540 109189280
Polycystic ovaries 19.45 11.05 19 1393460 4777 109191043
Graft versus host disease in lung 19.45 11.05 47 1393432 1231 109194589
Transplant dysfunction 19.39 11.05 48 1393431 8280 109187540
Hyperparathyroidism 19.37 11.05 12 1393467 3798 109192022
Squamous cell carcinoma of the cervix 19.36 11.05 22 1393457 298 109195522
Wernicke's encephalopathy 19.35 11.05 9 1393470 23 109195797
Enuresis 19.35 11.05 14 1393465 4082 109191738
Diabetic nephropathy 19.34 11.05 10 1393469 3498 109192322
Flank pain 19.32 11.05 192 1393287 22938 109172882
Catheter site pruritus 19.25 11.05 3 1393476 2303 109193517
Cardiac pacemaker insertion 19.24 11.05 31 1393448 6270 109189550
Suicidal behaviour 19.23 11.05 10 1393469 3487 109192333
Stomatitis necrotising 19.14 11.05 19 1393460 218 109195602
Protein urine present 19.13 11.05 77 1393402 11407 109184413
Prostate cancer stage IV 19.12 11.05 4 1393475 2484 109193336
Bone sarcoma 19.08 11.05 13 1393466 83 109195737
Atrial thrombosis 19.08 11.05 16 1393463 4330 109191490
Feeling cold 19.07 11.05 307 1393172 33680 109162140
Leprosy 19.03 11.05 17 1393462 169 109195651
Spinal cord disorder 19.01 11.05 66 1393413 2132 109193688
Solar urticaria 18.99 11.05 14 1393465 103 109195717
Large intestinal stenosis 18.92 11.05 96 1393383 3684 109192136
Induced abortion failed 18.90 11.05 16 1393463 147 109195673
Cystic fibrosis 18.89 11.05 19 1393460 4712 109191108
Acute psychosis 18.82 11.05 21 1393458 4966 109190854
Malignant melanoma stage I 18.81 11.05 16 1393463 148 109195672
Spinal cord compression 18.81 11.05 42 1393437 7510 109188310
Type 2 diabetes mellitus 18.81 11.05 2529 1390950 174703 109021117
Peritonitis 18.81 11.05 293 1393186 32314 109163506
Therapeutic response shortened 18.73 11.05 497 1392982 29086 109166734
Delusion of grandeur 18.73 11.05 3 1393476 2257 109193563
Macrocytosis 18.71 11.05 87 1393392 3220 109192600
Skin disorder 18.70 11.05 689 1392790 42224 109153596
Cell marker increased 18.70 11.05 32 1393447 649 109195171
Application site rash 18.70 11.05 4 1393475 2446 109193374
Herpes zoster cutaneous disseminated 18.69 11.05 28 1393451 505 109195315
Hip surgery 18.68 11.05 102 1393377 4028 109191792
Anaplastic large cell lymphoma T- and null-cell types 18.66 11.05 18 1393461 199 109195621
Bipolar disorder 18.65 11.05 55 1393424 8952 109186868
Stoma site discharge 18.60 11.05 6 1393473 2789 109193031
Device loosening 18.59 11.05 36 1393443 806 109195014
Malignant respiratory tract neoplasm 18.58 11.05 9 1393470 26 109195794
Angiotensin converting enzyme increased 18.57 11.05 17 1393462 175 109195645
Radiculopathy 18.54 11.05 155 1393324 19181 109176639
Vaginal infection 18.54 11.05 148 1393331 6656 109189164
Urine output increased 18.51 11.05 6 1393473 2780 109193040
Eczema infected 18.49 11.05 17 1393462 176 109195644
Haemothorax 18.43 11.05 38 1393441 6993 109188827
Breast abscess 18.42 11.05 56 1393423 1685 109194135
Acute monocytic leukaemia 18.39 11.05 30 1393449 584 109195236
Infective scleritis 18.36 11.05 14 1393465 109 109195711
Combined immunodeficiency 18.34 11.05 17 1393462 178 109195642
Oesophagitis 18.31 11.05 253 1393226 28462 109167358
Resuscitation 18.31 11.05 7 1393472 2926 109192894
Genital erosion 18.31 11.05 35 1393444 776 109195044
Meningitis coccidioides 18.28 11.05 10 1393469 40 109195780
Temperature intolerance 18.27 11.05 102 1393377 13848 109181972
Coronary artery bypass 18.20 11.05 30 1393449 6012 109189808
Staphylococcal abscess 18.13 11.05 46 1393433 1243 109194577
Salivary gland cancer 18.10 11.05 27 1393452 485 109195335
Philadelphia chromosome positive 18.10 11.05 37 1393442 863 109194957
Premature rupture of membranes 18.09 11.05 19 1393460 4618 109191202
Lymphocytic leukaemia 18.06 11.05 21 1393458 292 109195528
Peripheral coldness 18.06 11.05 148 1393331 18392 109177428
Herpes zoster oticus 18.06 11.05 32 1393447 668 109195152
Heavy chain disease 18.03 11.05 7 1393472 9 109195811
Mood swings 17.97 11.05 192 1393287 22620 109173200
Oropharyngeal discolouration 17.93 11.05 6 1393473 3 109195817
Small intestinal haemorrhage 17.92 11.05 19 1393460 4599 109191221
Large intestine anastomosis 17.92 11.05 13 1393466 93 109195727
Bronchioloalveolar carcinoma 17.91 11.05 10 1393469 42 109195778
Skin burning sensation 17.88 11.05 182 1393297 21643 109174177
Nodal arrhythmia 17.87 11.05 3 1393476 2181 109193639
Osteochondrosis 17.87 11.05 71 1393408 2450 109193370
Blood albumin decreased 17.86 11.05 243 1393236 27409 109168411
Monoclonal gammopathy 17.83 11.05 44 1393435 1168 109194652
Lower respiratory tract infection viral 17.80 11.05 49 1393430 1392 109194428
Herpes zoster meningitis 17.80 11.05 19 1393460 239 109195581
Minimal residual disease 17.78 11.05 38 1393441 915 109194905
Polyomavirus-associated nephropathy 17.78 11.05 49 1393430 8152 109187668
Drug-device interaction 17.77 11.05 14 1393465 115 109195705
Genital abscess 17.77 11.05 20 1393459 268 109195552
Psychogenic seizure 17.76 11.05 4 1393475 2360 109193460
Tenosynovitis stenosans 17.68 11.05 91 1393388 3512 109192308
Local reaction 17.66 11.05 34 1393445 758 109195062
Nail pitting 17.64 11.05 26 1393453 462 109195358
Rash pruritic 17.64 11.05 1033 1392446 97036 109098784
Cyst rupture 17.63 11.05 36 1393443 839 109194981
Poor quality device used 17.60 11.05 7 1393472 2856 109192964
Intra-abdominal haematoma 17.56 11.05 11 1393468 3461 109192359
Follicular lymphoma 17.56 11.05 33 1393446 722 109195098
Leukoplakia 17.55 11.05 17 1393462 189 109195631
Cholangitis 17.51 11.05 127 1393352 16208 109179612
Oral mucosal roughening 17.45 11.05 9 1393470 31 109195789
Brachiocephalic artery stenosis 17.45 11.05 9 1393470 31 109195789
Tetany 17.44 11.05 12 1393467 3592 109192228
Wrong schedule 17.41 11.05 32 1393447 688 109195132
Thymoma 17.40 11.05 24 1393455 400 109195420
Dislocation of vertebra 17.40 11.05 695 1392784 43026 109152794
Pupillary reflex impaired 17.36 11.05 15 1393464 4000 109191820
Mixed connective tissue disease 17.36 11.05 24 1393455 401 109195419
Skin weeping 17.34 11.05 13 1393466 3722 109192098
Anticonvulsant drug level decreased 17.33 11.05 3 1393476 2133 109193687
Discouragement 17.30 11.05 64 1393415 2134 109193686
Lymphocyte percentage decreased 17.30 11.05 25 1393454 5285 109190535
Soft tissue infection 17.30 11.05 117 1393362 4990 109190830
Hypertensive crisis 17.29 11.05 210 1393269 24162 109171658
Embolism 17.29 11.05 127 1393352 16162 109179658
Alcohol withdrawal syndrome 17.27 11.05 3 1393476 2127 109193693
Femur fracture 17.26 11.05 705 1392774 43764 109152056
Mucosal erosion 17.26 11.05 76 1393403 2748 109193072
Leukodystrophy 17.22 11.05 10 1393469 46 109195774
Nephropathy toxic 17.22 11.05 461 1393018 27017 109168803
Chloroma 17.21 11.05 35 1393444 813 109195007
Osteosarcoma 17.18 11.05 24 1393455 405 109195415
Metabolic disorder 17.17 11.05 71 1393408 10439 109185381
Malignant mediastinal neoplasm 17.17 11.05 47 1393432 1331 109194489
Erythema induratum 17.13 11.05 18 1393461 222 109195598
Stoma site erythema 17.12 11.05 3 1393476 2114 109193706
Skin neoplasm excision 17.11 11.05 61 1393418 1997 109193823
Decreased interest 17.11 11.05 22 1393457 4886 109190934
Mycoplasma test positive 17.08 11.05 19 1393460 251 109195569
Rhonchi 17.08 11.05 19 1393460 4499 109191321
Post procedural inflammation 17.07 11.05 18 1393461 223 109195597
Haemorrhoidal haemorrhage 17.06 11.05 49 1393430 8044 109187776
Liver sarcoidosis 17.06 11.05 8 1393471 21 109195799
Vaginal haemorrhage 17.05 11.05 218 1393261 24856 109170964
Precancerous cells present 17.01 11.05 45 1393434 1248 109194572
Purpura 16.98 11.05 211 1393268 24177 109171643
Squamous cell carcinoma of the tongue 16.97 11.05 34 1393445 781 109195039
Paraplegia 16.97 11.05 135 1393344 6065 109189755
Endometriosis 16.97 11.05 103 1393376 4231 109191589
Skin irritation 16.95 11.05 128 1393351 16191 109179629
Renal cell carcinoma 16.95 11.05 157 1393322 7373 109188447
Pneumonia viral 16.93 11.05 215 1393264 10942 109184878
Lower limb fracture 16.89 11.05 1134 1392345 74214 109121606
Actinomycotic pulmonary infection 16.89 11.05 10 1393469 48 109195772
Subacute combined cord degeneration 16.89 11.05 22 1393457 346 109195474
Post inflammatory pigmentation change 16.89 11.05 33 1393446 744 109195076
Differential white blood cell count abnormal 16.89 11.05 4 1393475 2280 109193540
Perineal necrosis 16.86 11.05 16 1393463 173 109195647
Low density lipoprotein increased 16.84 11.05 73 1393406 10593 109185227
Physical deconditioning 16.82 11.05 12 1393467 3525 109192295
Histiocytic necrotising lymphadenitis 16.81 11.05 11 1393468 65 109195755
Laryngitis fungal 16.79 11.05 16 1393463 174 109195646
Non-small cell lung cancer stage II 16.75 11.05 6 1393473 5 109195815
Arrhythmia supraventricular 16.73 11.05 5 1393474 2441 109193379
Food intolerance 16.73 11.05 106 1393373 4421 109191399
Cutaneous vasculitis 16.72 11.05 239 1393240 12490 109183330
Perineal infection 16.68 11.05 35 1393444 832 109194988
Facial paresis 16.67 11.05 133 1393346 5980 109189840
Infected bite 16.66 11.05 61 1393418 2024 109193796
Capillaritis 16.65 11.05 5 1393474 2434 109193386
Upper-airway cough syndrome 16.65 11.05 124 1393355 15733 109180087
Eye pain 16.64 11.05 492 1392987 49607 109146213
Granulocytopenia 16.63 11.05 93 1393386 12622 109183198
Guttate psoriasis 16.61 11.05 27 1393452 524 109195296
Liver transplant 16.59 11.05 20 1393459 4569 109191251
Gastrointestinal lymphoma 16.58 11.05 18 1393461 231 109195589
Bacteroides infection 16.58 11.05 8 1393471 2911 109192909
Retinal injury 16.57 11.05 25 1393454 454 109195366
Injection site papule 16.54 11.05 39 1393440 1005 109194815
Drug eruption 16.53 11.05 831 1392648 52828 109142992
Bone formation decreased 16.48 11.05 13 1393466 107 109195713
Colitis 16.45 11.05 1089 1392390 101234 109094586
Hypertensive emergency 16.43 11.05 11 1393468 3340 109192480
Fracture delayed union 16.43 11.05 63 1393416 2138 109193682
Contraindication to vaccination 16.41 11.05 17 1393462 206 109195614
Pyoderma 16.40 11.05 27 1393452 530 109195290
Central nervous system vasculitis 16.39 11.05 52 1393427 1602 109194218
Malignant neoplasm of conjunctiva 16.30 11.05 11 1393468 69 109195751
Cholecystitis acute 16.30 11.05 124 1393355 15658 109180162
Cytomegalovirus colitis 16.29 11.05 148 1393331 6913 109188907
Nasal septum perforation 16.28 11.05 36 1393443 888 109194932
Endotracheal intubation 16.28 11.05 33 1393446 6111 109189709
Tendon graft 16.24 11.05 6 1393473 6 109195814
Heavy menstrual bleeding 16.23 11.05 130 1393349 16235 109179585
Contrast media reaction 16.22 11.05 5 1393474 2393 109193427
Rotator cuff repair 16.21 11.05 64 1393415 2202 109193618
T-cell type acute leukaemia 16.18 11.05 21 1393458 329 109195491
Herpes ophthalmic 16.18 11.05 56 1393423 1806 109194014
Delayed recovery from anaesthesia 16.14 11.05 4 1393475 2211 109193609
Cervix carcinoma stage 0 16.14 11.05 19 1393460 268 109195552
Sensory disturbance 16.14 11.05 141 1393338 17288 109178532
Quadriplegia 16.10 11.05 98 1393381 4029 109191791
Encephalitis brain stem 16.09 11.05 21 1393458 331 109195489
Loss of employment 16.09 11.05 84 1393395 3260 109192560
Hemianopia 16.08 11.05 8 1393471 2860 109192960
Oral infection 16.06 11.05 136 1393343 6225 109189595
Nephrosclerosis 16.05 11.05 3 1393476 2018 109193802
Hepatic cancer 16.05 11.05 79 1393400 11077 109184743
Disorganised speech 15.98 11.05 11 1393468 3292 109192528
Multiple organ dysfunction syndrome 15.98 11.05 1670 1391809 150040 109045780
Nodal osteoarthritis 15.97 11.05 35 1393444 858 109194962
Diverticulum intestinal haemorrhagic 15.94 11.05 22 1393457 4741 109191079
Hypoacusis 15.94 11.05 330 1393149 34861 109160959
Type 1 lepra reaction 15.93 11.05 11 1393468 72 109195748
Tongue disorder 15.91 11.05 261 1393218 14037 109181783
Hypokinesia 15.89 11.05 187 1393292 21639 109174181
Oral toxicity 15.88 11.05 7 1393472 15 109195805
Facet joint syndrome 15.87 11.05 1422 1392057 95406 109100414
Bronchiolitis obliterans syndrome 15.85 11.05 30 1393449 660 109195160
Presbyacusis 15.83 11.05 74 1393405 2745 109193075
Bruxism 15.79 11.05 24 1393455 4970 109190850
Attention deficit hyperactivity disorder 15.79 11.05 20 1393459 4471 109191349
Human rhinovirus test positive 15.79 11.05 43 1393436 1214 109194606
Dry mouth 15.78 11.05 2243 1391236 197705 108998115
Intestinal resection 15.78 11.05 94 1393385 3835 109191985
Thymus hypoplasia 15.77 11.05 52 1393427 1635 109194185
Cholera 15.77 11.05 6 1393473 7 109195813
Seminoma 15.77 11.05 19 1393460 275 109195545
Incision site pain 15.77 11.05 10 1393469 3125 109192695
Bronchitis bacterial 15.77 11.05 55 1393424 1781 109194039
Loss of libido 15.75 11.05 10 1393469 3123 109192697
Lower respiratory tract congestion 15.72 11.05 109 1393370 4687 109191133
Joint surgery 15.72 11.05 22 1393457 372 109195448
Spinal meningioma benign 15.68 11.05 12 1393467 94 109195726
Bone marrow disorder 15.68 11.05 99 1393380 4124 109191696
Skin infection 15.68 11.05 383 1393096 22126 109173694
Vaginal cancer 15.67 11.05 17 1393462 218 109195602
Infusion site rash 15.65 11.05 5 1393474 2338 109193482
Pneumonitis 15.63 11.05 1143 1392336 75388 109120432
Libido decreased 15.62 11.05 32 1393447 5903 109189917
Facial bones fracture 15.61 11.05 24 1393455 4947 109190873
Substance use 15.61 11.05 6 1393473 2500 109193320
Tender joint count 15.59 11.05 46 1393433 1361 109194459
Leukaemia 15.56 11.05 154 1393325 7364 109188456
Mediastinal cyst 15.56 11.05 10 1393469 57 109195763
Coordination abnormal 15.48 11.05 224 1393255 25004 109170816
IgA nephropathy 15.47 11.05 80 1393399 3093 109192727
Fibrinous bronchitis 15.45 11.05 14 1393465 142 109195678
Symptom recurrence 15.38 11.05 108 1393371 4664 109191156
Pulmonary congestion 15.35 11.05 286 1393193 30680 109165140
Pulmonary function test decreased 15.35 11.05 57 1393422 8643 109187177
Appetite disorder 15.34 11.05 67 1393412 9702 109186118
Juvenile spondyloarthritis 15.34 11.05 6 1393473 8 109195812
Furuncle 15.33 11.05 172 1393307 8496 109187324
Removal of internal fixation 15.30 11.05 7 1393472 17 109195803
Lung squamous cell carcinoma stage I 15.30 11.05 7 1393472 17 109195803
Central nervous system mass 15.27 11.05 33 1393446 801 109195019
Ligament calcification 15.26 11.05 17 1393462 225 109195595
White matter lesion 15.25 11.05 72 1393407 2682 109193138
Loss of control of legs 15.25 11.05 4 1393475 2128 109193692
Disseminated toxoplasmosis 15.24 11.05 24 1393455 453 109195367
Hypocomplementaemia 15.24 11.05 20 1393459 317 109195503
Post transplant lymphoproliferative disorder 15.21 11.05 279 1393200 15334 109180486
Generalised anxiety disorder 15.21 11.05 8 1393471 2771 109193049
Vascular stent thrombosis 15.19 11.05 18 1393461 4143 109191677
Eosinophilic granulomatosis with polyangiitis 15.18 11.05 76 1393403 10610 109185210
Bursa disorder 15.18 11.05 18 1393461 256 109195564
Abortion induced 15.17 11.05 51 1393428 7968 109187852
Tic 15.16 11.05 13 1393466 3480 109192340
Insulin-like growth factor increased 15.15 11.05 5 1393474 2291 109193529
Obstruction 15.15 11.05 31 1393448 5721 109190099
Thiopurine methyltransferase decreased 15.15 11.05 20 1393459 319 109195501
Application site irritation 15.12 11.05 3 1393476 1934 109193886
Eye movement disorder 15.11 11.05 67 1393412 9661 109186159
American trypanosomiasis 15.11 11.05 28 1393451 606 109195214
Sputum culture positive 15.10 11.05 16 1393463 3873 109191947
Nasal cavity cancer 15.06 11.05 19 1393460 289 109195531
Disease susceptibility 15.05 11.05 20 1393459 321 109195499
DNA antibody positive 15.05 11.05 20 1393459 321 109195499
Lung transplant rejection 15.05 11.05 3 1393476 1928 109193892
Dengue fever 15.05 11.05 44 1393435 1295 109194525
Actinomycosis 15.03 11.05 44 1393435 1296 109194524
Otitis media acute 15.01 11.05 49 1393430 1533 109194287
Idiopathic pneumonia syndrome 15.00 11.05 34 1393445 853 109194967
Red cell distribution width decreased 15 11.05 62 1393417 2179 109193641
Lacrimation increased 14.99 11.05 287 1393192 30663 109165157
Foreign body sensation in eyes 14.97 11.05 12 1393467 3322 109192498
Uterine cancer 14.97 11.05 97 1393382 4077 109191743
Hypermobility syndrome 14.97 11.05 26 1393453 534 109195286
Bladder neoplasm 14.96 11.05 56 1393423 1878 109193942
Vulval cancer 14.96 11.05 27 1393452 572 109195248
Blood creatine phosphokinase MB increased 14.96 11.05 9 1393470 2894 109192926
Embolic stroke 14.96 11.05 58 1393421 8685 109187135
Renal tubular atrophy 14.95 11.05 5 1393474 2271 109193549
Aphakia 14.94 11.05 6 1393473 9 109195811
Squamous cell carcinoma of the vagina 14.94 11.05 6 1393473 9 109195811
Enthesophyte 14.93 11.05 14 1393465 149 109195671
Acral lentiginous melanoma 14.92 11.05 9 1393470 45 109195775
Thymoma benign 14.92 11.05 9 1393470 45 109195775
Ankle brachial index decreased 14.91 11.05 11 1393468 81 109195739
HCoV-HKU1 infection 14.91 11.05 10 1393469 62 109195758
Scedosporium infection 14.91 11.05 66 1393413 2392 109193428
Infusion site infection 14.90 11.05 5 1393474 2267 109193553
Candida infection 14.89 11.05 744 1392735 47265 109148555
Concomitant disease aggravated 14.88 11.05 133 1393346 16231 109179589
Right ventricular dysfunction 14.88 11.05 12 1393467 3311 109192509
Ulcerative keratitis 14.86 11.05 107 1393372 4659 109191161
Exercise tolerance decreased 14.86 11.05 90 1393389 11977 109183843
Subcutaneous haematoma 14.84 11.05 10 1393469 3026 109192794
Mucocutaneous disorder 14.76 11.05 16 1393463 205 109195615
Vasculitic rash 14.76 11.05 62 1393417 2195 109193625
Pain in jaw 14.74 11.05 512 1392967 50665 109145155
Bone marrow leukaemic cell infiltration 14.73 11.05 12 1393467 104 109195716
Hyperparathyroidism secondary 14.71 11.05 12 1393467 3292 109192528
Septic shock 14.68 11.05 2231 1391248 155297 109040523
Ventricular hypokinesia 14.68 11.05 82 1393397 11132 109184688
Symmetrical drug-related intertriginous and flexural exanthema 14.68 11.05 3 1393476 1894 109193926
Toxoplasmosis 14.66 11.05 80 1393399 3159 109192661
Herpes gestationis 14.62 11.05 5 1393474 3 109195817
Peripheral vascular disorder 14.60 11.05 57 1393422 8519 109187301
Tuberculosis of eye 14.60 11.05 11 1393468 84 109195736
Anovulatory cycle 14.57 11.05 13 1393466 129 109195691
Gastrointestinal sounds abnormal 14.56 11.05 34 1393445 5984 109189836
PO2 decreased 14.56 11.05 11 1393468 3137 109192683
Uterine disorder 14.52 11.05 63 1393416 2263 109193557
Adenoviral haemorrhagic cystitis 14.51 11.05 29 1393450 665 109195155
Steroid dependence 14.51 11.05 167 1393312 8302 109187518
Splenic infection fungal 14.49 11.05 14 1393465 155 109195665
B-cell lymphoma stage IV 14.49 11.05 11 1393468 85 109195735
Diffuse alveolar damage 14.48 11.05 94 1393385 3953 109191867
Chimerism 14.44 11.05 19 1393460 302 109195518
Tumour marker increased 14.44 11.05 26 1393453 5034 109190786
Carbohydrate antigen 125 increased 14.43 11.05 7 1393472 2540 109193280
Oesophageal stenosis 14.43 11.05 113 1393366 5052 109190768
Intestinal fibrosis 14.41 11.05 18 1393461 271 109195549
Herpes simplex reactivation 14.40 11.05 46 1393433 1422 109194398
Cardiac operation 14.40 11.05 34 1393445 5961 109189859
Salmonellosis 14.37 11.05 61 1393418 2170 109193650
Lupus vasculitis 14.36 11.05 27 1393452 591 109195229
Expired product administered 14.36 11.05 55 1393424 8265 109187555
Allergy to vaccine 14.35 11.05 16 1393463 212 109195608
Photopsia 14.33 11.05 36 1393443 6178 109189642
Implant site pain 14.31 11.05 5 1393474 2210 109193610
Femoral neck fracture 14.31 11.05 96 1393383 12471 109183349
Diabetic neuropathy 14.31 11.05 43 1393436 6956 109188864
Limbal stem cell deficiency 14.30 11.05 10 1393469 67 109195753
Pyopneumothorax 14.30 11.05 10 1393469 67 109195753
Neoscytalidium infection 14.27 11.05 7 1393472 21 109195799
Femoroacetabular impingement 14.27 11.05 7 1393472 21 109195799
Dermatopathic lymphadenopathy 14.26 11.05 8 1393471 34 109195786
Dysphoria 14.24 11.05 38 1393441 6390 109189430
Intraventricular haemorrhage 14.24 11.05 30 1393449 5477 109190343
Drainage 14.22 11.05 17 1393462 244 109195576
Psoriasis area severity index decreased 14.21 11.05 6 1393473 11 109195809
Gastric neoplasm 14.17 11.05 20 1393459 341 109195479
Blood pressure abnormal 14.15 11.05 198 1393281 22226 109173594
Pre-existing condition improved 14.14 11.05 39 1393440 6487 109189333
White blood cells urine positive 14.14 11.05 48 1393431 7476 109188344
Blood 1,25-dihydroxycholecalciferol increased 14.09 11.05 11 1393468 89 109195731
Segmented hyalinising vasculitis 14.09 11.05 11 1393468 89 109195731
Chorea 14.09 11.05 12 1393467 3223 109192597
Oxygen therapy 14.08 11.05 19 1393460 4134 109191686
Clostridium test positive 14.07 11.05 80 1393399 10813 109185007
Bone marrow transplant rejection 14.07 11.05 19 1393460 310 109195510
Pertussis 14.07 11.05 42 1393437 1251 109194569
Rocky mountain spotted fever 14.05 11.05 9 1393470 51 109195769
Allergic fungal rhinosinusitis 14.05 11.05 9 1393470 51 109195769
Infectious thyroiditis 14.03 11.05 15 1393464 189 109195631
Flat affect 14.02 11.05 7 1393472 2498 109193322
Amyloidosis 14.01 11.05 78 1393401 3103 109192717
Transplant evaluation 14.00 11.05 3 1393476 1832 109193988
Brain oedema 13.97 11.05 292 1393187 30806 109165014
Wall motion score index abnormal 13.96 11.05 32 1393447 809 109195011
Soft tissue disorder 13.95 11.05 84 1393395 3440 109192380
Tongue biting 13.94 11.05 10 1393469 2929 109192891
Cerebral salt-wasting syndrome 13.92 11.05 18 1393461 281 109195539
Cerebral fungal infection 13.91 11.05 29 1393450 686 109195134
Vascular rupture 13.91 11.05 53 1393426 1793 109194027
Acute interstitial pneumonitis 13.91 11.05 45 1393434 1401 109194419
Laryngeal stenosis 13.89 11.05 44 1393435 1354 109194466
Endocarditis Q fever 13.88 11.05 6 1393473 12 109195808
Glottis carcinoma 13.88 11.05 6 1393473 12 109195808
Adactyly 13.88 11.05 6 1393473 12 109195808
Movement disorder 13.87 11.05 576 1392903 35828 109159992
Disseminated aspergillosis 13.86 11.05 65 1393414 2415 109193405
Genital infection 13.84 11.05 16 1393463 221 109195599
Candida test positive 13.79 11.05 43 1393436 1312 109194508
Overwork 13.78 11.05 9 1393470 53 109195767
Pulmonary alveolar haemorrhage 13.78 11.05 175 1393304 19975 109175845
Rib fracture 13.76 11.05 322 1393157 33448 109162372
Renal ischaemia 13.76 11.05 6 1393473 2317 109193503
Acute myelomonocytic leukaemia 13.76 11.05 22 1393457 421 109195399
Bladder transitional cell carcinoma 13.73 11.05 71 1393408 2745 109193075
Cutaneous T-cell lymphoma recurrent 13.71 11.05 11 1393468 93 109195727
Autonomic nervous system imbalance 13.71 11.05 33 1393446 5747 109190073
Abdominal pain lower 13.70 11.05 361 1393118 36922 109158898
Pancreatic calcification 13.70 11.05 17 1393462 254 109195566
Tension 13.69 11.05 27 1393452 5051 109190769
Abnormal weight gain 13.69 11.05 15 1393464 3576 109192244
Hiatus hernia 13.67 11.05 255 1393224 27351 109168469
Non-cardiac chest pain 13.66 11.05 74 1393405 10124 109185696
Lipoma 13.63 11.05 91 1393388 3864 109191956
Cytomegalovirus gastroenteritis 13.61 11.05 29 1393450 697 109195123
Colon cancer stage II 13.60 11.05 17 1393462 256 109195564
PCO2 increased 13.60 11.05 4 1393475 1973 109193847
Chemokine increased 13.59 11.05 7 1393472 24 109195796
Natural killer cell count increased 13.57 11.05 6 1393473 13 109195807
Silicosis 13.57 11.05 6 1393473 13 109195807
Shoulder operation 13.57 11.05 82 1393397 3363 109192457
Infusion site discharge 13.55 11.05 4 1393475 1969 109193851
Renal tubular injury 13.55 11.05 76 1393403 3032 109192788
Leukaemia monocytic 13.55 11.05 4 1393475 0 109195820
Merkel cell polyomavirus infection 13.55 11.05 4 1393475 0 109195820
Necrotising fasciitis staphylococcal 13.55 11.05 4 1393475 0 109195820
Synovial fluid analysis abnormal 13.55 11.05 4 1393475 0 109195820
Lymphoid tissue hypoplasia 13.55 11.05 49 1393430 1616 109194204
Eye abscess 13.54 11.05 20 1393459 356 109195464
Corneal oedema 13.54 11.05 12 1393467 3161 109192659
Lipids increased 13.53 11.05 55 1393424 1918 109193902
Cardiolipin antibody 13.53 11.05 5 1393474 5 109195815
Spinal rod insertion 13.53 11.05 5 1393474 5 109195815
Bladder neck operation 13.53 11.05 5 1393474 5 109195815
Noninfective chorioretinitis 13.53 11.05 5 1393474 5 109195815
Yolk sac tumour site unspecified 13.53 11.05 5 1393474 5 109195815
Fanconi syndrome acquired 13.53 11.05 11 1393468 3023 109192797
Butterfly rash 13.52 11.05 58 1393421 2073 109193747
Skin dystrophy 13.52 11.05 9 1393470 55 109195765
Fluid intake reduced 13.52 11.05 44 1393435 6942 109188878
Vitamin D deficiency 13.49 11.05 159 1393320 18393 109177427
Limb mass 13.49 11.05 91 1393388 3878 109191942
Thalamus haemorrhage 13.46 11.05 4 1393475 1960 109193860
Salpingo-oophoritis 13.46 11.05 12 1393467 119 109195701
Erythematotelangiectatic rosacea 13.46 11.05 12 1393467 119 109195701
Pelvic pain 13.45 11.05 132 1393347 15810 109180010
Electrocardiogram ST segment abnormal 13.45 11.05 3 1393476 1782 109194038
Stoma site pain 13.45 11.05 4 1393475 1959 109193861
Cytomegalovirus hepatitis 13.45 11.05 33 1393446 873 109194947
Residual urine volume increased 13.44 11.05 11 1393468 96 109195724
Spontaneous haematoma 13.43 11.05 4 1393475 1957 109193863
Sebaceous adenoma 13.42 11.05 8 1393471 39 109195781
Prostate cancer stage III 13.42 11.05 3 1393476 1779 109194041
Large intestinal ulcer 13.42 11.05 121 1393358 5640 109190180
Injection site extravasation 13.38 11.05 191 1393288 9978 109185842
Skin discolouration 13.37 11.05 494 1392985 48552 109147268
Exposed bone in jaw 13.37 11.05 17 1393462 3794 109192026
Culture urine positive 13.37 11.05 25 1393454 4771 109191049
Feeling drunk 13.36 11.05 31 1393448 5469 109190351
Encephalitis enteroviral 13.36 11.05 17 1393462 261 109195559
Drug tolerance 13.35 11.05 288 1393191 16297 109179523
Lung adenocarcinoma stage IV 13.33 11.05 25 1393454 546 109195274
Tendon pain 13.30 11.05 130 1393349 6196 109189624
Duodenitis 13.30 11.05 65 1393414 9131 109186689
Vulval disorder 13.28 11.05 33 1393446 880 109194940
Leptotrichia infection 13.27 11.05 9 1393470 57 109195763
Spleen tuberculosis 13.26 11.05 8 1393471 40 109195780
Central nervous system enteroviral infection 13.26 11.05 11 1393468 98 109195722
Refractoriness to platelet transfusion 13.26 11.05 16 1393463 232 109195588
Arthroscopy 13.25 11.05 27 1393452 628 109195192
Immunoglobulin G4 related disease 13.24 11.05 21 1393458 399 109195421
Urosepsis 13.21 11.05 290 1393189 30385 109165435
Magnetic resonance imaging head abnormal 13.20 11.05 83 1393396 3452 109192368
Purulent discharge 13.19 11.05 142 1393337 6941 109188879
Microangiopathy 13.18 11.05 73 1393406 2899 109192921
Ischaemic hepatitis 13.16 11.05 24 1393455 4624 109191196
Joint fluid drainage 13.14 11.05 18 1393461 298 109195522
Joint abscess 13.14 11.05 28 1393451 673 109195147
Subacute cutaneous lupus erythematosus 13.08 11.05 27 1393452 4967 109190853
Carotid artery thrombosis 13.07 11.05 182 1393297 9456 109186364
Tongue neoplasm 13.07 11.05 12 1393467 124 109195696
Prothrombin time shortened 13.07 11.05 16 1393463 3630 109192190
Anorectal disorder 13.07 11.05 69 1393410 2690 109193130
Spinal osteoarthritis 13.04 11.05 340 1393139 19843 109175977
Papilloma 13.03 11.05 24 1393455 517 109195303
Nasal mucosal ulcer 12.99 11.05 6 1393473 15 109195805
Anti-saccharomyces cerevisiae antibody 12.99 11.05 6 1393473 15 109195805
Joint contracture 12.99 11.05 64 1393415 2427 109193393
Cutaneous T-cell lymphoma refractory 12.98 11.05 7 1393472 27 109195793
Oral lichen planus 12.95 11.05 33 1393446 894 109194926
X-ray abnormal 12.94 11.05 596 1392883 37521 109158299
Shunt occlusion 12.93 11.05 3 1393476 1734 109194086
Angle closure glaucoma 12.92 11.05 15 1393464 3484 109192336
Salivary gland neoplasm 12.91 11.05 11 1393468 102 109195718
Blood potassium abnormal 12.91 11.05 19 1393460 3986 109191834
Posthaemorrhagic hydrocephalus 12.90 11.05 9 1393470 60 109195760
Psoas abscess 12.90 11.05 45 1393434 1457 109194363
Skin atrophy 12.89 11.05 133 1393346 6431 109189389
Capnocytophaga infection 12.88 11.05 14 1393465 180 109195640
Left atrial enlargement 12.86 11.05 3 1393476 1728 109194092
Glucose tolerance impaired 12.84 11.05 72 1393407 9765 109186055
Infusion site mass 12.83 11.05 3 1393476 1725 109194095
Ligament rupture 12.82 11.05 91 1393388 3944 109191876
Perirectal abscess 12.81 11.05 59 1393420 2175 109193645
Anal incontinence 12.79 11.05 197 1393282 21767 109174053
Ovarian adenoma 12.77 11.05 15 1393464 211 109195609
Nasal obstruction 12.76 11.05 14 1393465 3336 109192484
Necrotising scleritis 12.74 11.05 17 1393462 274 109195546
Fontanelle bulging 12.73 11.05 6 1393473 16 109195804
Respiratory tract ulceration 12.73 11.05 6 1393473 16 109195804
Drug use disorder 12.72 11.05 156 1393323 17918 109177902
Pyuria 12.71 11.05 9 1393470 2654 109193166
Pulse waveform abnormal 12.71 11.05 10 1393469 82 109195738
Depression suicidal 12.71 11.05 26 1393453 4798 109191022
Palatal ulcer 12.70 11.05 16 1393463 243 109195577
Parathyroid disorder 12.69 11.05 27 1393452 648 109195172
Laryngeal oedema 12.68 11.05 72 1393407 9735 109186085
Cytomegalovirus enteritis 12.67 11.05 36 1393443 1042 109194778
Carotid intima-media thickness increased 12.66 11.05 11 1393468 105 109195715
Hamartoma 12.64 11.05 5 1393474 7 109195813
Oesophageal carcinoma 12.64 11.05 89 1393390 11435 109184385
Central venous catheterisation 12.60 11.05 18 1393461 3824 109191996
Drug level below therapeutic 12.59 11.05 212 1393267 11461 109184359
Bladder transitional cell carcinoma recurrent 12.58 11.05 14 1393465 185 109195635
Gastritis erosive 12.52 11.05 94 1393385 11906 109183914
Immune-mediated adverse reaction 12.52 11.05 3 1393476 1697 109194123
Follicle centre lymphoma, follicular grade I, II, III 12.52 11.05 10 1393469 84 109195736
Neutrophil percentage increased 12.50 11.05 27 1393452 4886 109190934
Slow speech 12.50 11.05 15 1393464 3433 109192387
Seasonal allergy 12.49 11.05 174 1393305 19548 109176272
Precursor T-lymphoblastic lymphoma/leukaemia 12.48 11.05 12 1393467 132 109195688
Internal haemorrhage 12.46 11.05 75 1393404 9996 109185824
Metabolic alkalosis 12.45 11.05 33 1393446 5562 109190258
Immunosuppressant drug level decreased 12.41 11.05 10 1393469 2761 109193059
Ostomy bag placement 12.40 11.05 8 1393471 46 109195774
Toxoplasma serology positive 12.40 11.05 8 1393471 46 109195774
Haematocolpos 12.40 11.05 8 1393471 46 109195774
Scarlet fever 12.39 11.05 13 1393466 160 109195660
Mononeuropathy multiplex 12.35 11.05 31 1393448 832 109194988
Seroma 12.35 11.05 14 1393465 3287 109192533
Torus fracture 12.34 11.05 12 1393467 134 109195686
Eye infection 12.30 11.05 254 1393225 14264 109181556
Lung opacity 12.29 11.05 91 1393388 11561 109184259
Device related sepsis 12.28 11.05 52 1393427 7595 109188225
Catheter site swelling 12.27 11.05 7 1393472 2317 109193503
Hepatic candidiasis 12.26 11.05 11 1393468 110 109195710
Lichen myxoedematosus 12.26 11.05 8 1393471 47 109195773
Bacterial myositis 12.26 11.05 5 1393474 8 109195812
Ear canal stenosis 12.26 11.05 5 1393474 8 109195812
CSF cell count decreased 12.26 11.05 5 1393474 8 109195812
Ossicle disorder 12.26 11.05 7 1393472 31 109195789
Therapeutic response delayed 12.25 11.05 42 1393437 1348 109194472
Sinus arrhythmia 12.24 11.05 6 1393473 2164 109193656
Self-medication 12.23 11.05 39 1393440 6193 109189627
Androgenetic alopecia 12.22 11.05 16 1393463 253 109195567
Normal newborn 12.21 11.05 198 1393281 21698 109174122
Cell-mediated immune deficiency 12.20 11.05 15 1393464 222 109195598
Mucosal infection 12.18 11.05 23 1393456 505 109195315
Gastric cyst 12.15 11.05 10 1393469 88 109195732
Cranial nerve disorder 12.15 11.05 40 1393439 1257 109194563
Blood beta-D-glucan increased 12.13 11.05 29 1393450 754 109195066
Cytogenetic abnormality 12.10 11.05 38 1393441 1164 109194656
Adenoviral hepatitis 12.10 11.05 34 1393445 978 109194842
Laryngitis 12.09 11.05 652 1392827 41759 109154061
Sputum discoloured 12.09 11.05 264 1393215 27681 109168139
Acute lymphocytic leukaemia refractory 12.08 11.05 14 1393465 194 109195626
Poikiloderma 12.06 11.05 22 1393457 470 109195350
Spinal fusion surgery 12.06 11.05 172 1393307 8984 109186836
Meningitis viral 12.06 11.05 61 1393418 2338 109193482
Formication 12.05 11.05 34 1393445 5614 109190206
Infectious pleural effusion 12.05 11.05 104 1393375 4787 109191033
Cardiac valve disease 12.04 11.05 41 1393438 6380 109189440
Lentigo 12.01 11.05 29 1393450 759 109195061
Lower motor neurone lesion 12.00 11.05 8 1393471 49 109195771
Acquired claw toe 12.00 11.05 8 1393471 49 109195771
Sarcoma 11.99 11.05 34 1393445 983 109194837
Blood parathyroid hormone increased 11.97 11.05 22 1393457 4226 109191594
Pseudomonas test positive 11.93 11.05 60 1393419 2294 109193526
Type 1 diabetes mellitus 11.93 11.05 66 1393413 8981 109186839
Retinal dystrophy 11.92 11.05 7 1393472 33 109195787
Scar excision 11.91 11.05 9 1393470 69 109195751
Head discomfort 11.90 11.05 168 1393311 18832 109176988
Vulval cancer stage III 11.90 11.05 5 1393474 9 109195811
Meningeal thickening 11.90 11.05 5 1393474 9 109195811
Intestinal malrotation 11.90 11.05 5 1393474 9 109195811
Bone graft 11.89 11.05 29 1393450 764 109195056
Purulent pericarditis 11.88 11.05 11 1393468 115 109195705
Lip scab 11.88 11.05 11 1393468 115 109195705
Anaplastic thyroid cancer 11.88 11.05 8 1393471 50 109195770
Cutaneous T-cell lymphoma stage II 11.88 11.05 8 1393471 50 109195770
Biliary dilatation 11.88 11.05 17 1393462 3608 109192212
Retroperitoneal haemorrhage 11.87 11.05 38 1393441 6027 109189793
Hepatopulmonary syndrome 11.86 11.05 14 1393465 198 109195622
Chest expansion decreased 11.86 11.05 14 1393465 198 109195622
Injection site hypersensitivity 11.84 11.05 62 1393417 2409 109193411
Vena cava thrombosis 11.83 11.05 16 1393463 3478 109192342
Skin tightness 11.82 11.05 34 1393445 5579 109190241
Forced vital capacity decreased 11.81 11.05 5 1393474 1965 109193855
Biliary dyskinesia 11.80 11.05 8 1393471 2413 109193407
Borrelia infection 11.78 11.05 17 1393462 296 109195524
Chronic actinic dermatitis 11.77 11.05 6 1393473 20 109195800
Fistula of small intestine 11.77 11.05 35 1393444 1040 109194780
Disease complication 11.77 11.05 36 1393443 5791 109190029
Facial pain 11.72 11.05 130 1393349 15209 109180611
Inflammatory pseudotumour 11.72 11.05 10 1393469 93 109195727
Anal prolapse 11.71 11.05 9 1393470 71 109195749
Wound infection pseudomonas 11.71 11.05 8 1393471 2403 109193417
Intestinal polyp 11.68 11.05 61 1393418 2368 109193452
Bronchopleural fistula 11.67 11.05 31 1393448 862 109194958
Mediastinal mass 11.64 11.05 28 1393451 731 109195089
Histiocytic sarcoma 11.63 11.05 10 1393469 94 109195726
Cerebral candidiasis 11.61 11.05 9 1393470 72 109195748
Airway remodelling 11.61 11.05 32 1393447 910 109194910
Giant cell arteritis 11.59 11.05 84 1393395 3665 109192155
Muscle swelling 11.57 11.05 35 1393444 1050 109194770
Ureterocele 11.57 11.05 5 1393474 10 109195810
Rheumatoid factor quantitative increased 11.57 11.05 5 1393474 10 109195810
Culture tissue specimen positive 11.57 11.05 5 1393474 10 109195810
Vulvovaginitis streptococcal 11.57 11.05 5 1393474 10 109195810
Breast mass 11.56 11.05 155 1393324 7986 109187834
Glomerulonephritis membranous 11.56 11.05 53 1393426 1950 109193870
Cutaneous T-cell lymphoma stage IV 11.51 11.05 8 1393471 53 109195767
Hippocampal sclerosis 11.50 11.05 14 1393465 205 109195615
Terminal insomnia 11.49 11.05 5 1393474 1933 109193887
Hepatocellular carcinoma 11.49 11.05 75 1393404 9805 109186015
Blood calcium abnormal 11.42 11.05 4 1393475 1765 109194055
Urethral polyp 11.42 11.05 9 1393470 74 109195746
Venous injury 11.41 11.05 33 1393446 965 109194855
Nodular melanoma 11.41 11.05 16 1393463 271 109195549
CSF protein increased 11.39 11.05 43 1393436 1448 109194372
Ocular discomfort 11.39 11.05 62 1393417 8471 109187349
Relapsing-remitting multiple sclerosis 11.38 11.05 6 1393473 2076 109193744
Intestinal tuberculosis 11.37 11.05 16 1393463 272 109195548
Stem cell transplant 11.36 11.05 95 1393384 4332 109191488
Frontotemporal dementia 11.35 11.05 26 1393453 657 109195163
Spherocytic anaemia 11.35 11.05 4 1393475 3 109195817
Yersinia test positive 11.35 11.05 4 1393475 3 109195817
Waldenstrom's macroglobulinaemia 11.35 11.05 4 1393475 3 109195817
Myxoid cyst 11.35 11.05 4 1393475 3 109195817
Tuberculin test false negative 11.35 11.05 4 1393475 3 109195817
Polydipsia 11.32 11.05 54 1393425 7634 109188186
Decreased immune responsiveness 11.31 11.05 177 1393302 9429 109186391
Portosplenomesenteric venous thrombosis 11.31 11.05 7 1393472 37 109195783
Mucous stools 11.28 11.05 134 1393345 6713 109189107
Systemic toxicity 11.27 11.05 18 1393461 344 109195476
Product odour abnormal 11.26 11.05 3 1393476 1580 109194240
Hodgkin's disease mixed cellularity stage unspecified 11.26 11.05 5 1393474 11 109195809
Gingival hyperpigmentation 11.26 11.05 5 1393474 11 109195809
Groin abscess 11.25 11.05 52 1393427 1920 109193900
Dyspnoea paroxysmal nocturnal 11.24 11.05 9 1393470 2493 109193327
Persecutory delusion 11.24 11.05 41 1393438 6250 109189570
Erythema migrans 11.23 11.05 11 1393468 124 109195696
Cranial nerve palsies multiple 11.23 11.05 15 1393464 242 109195578
Product container issue 11.23 11.05 3 1393476 1577 109194243
Premature separation of placenta 11.23 11.05 3 1393476 1577 109194243
Deafness neurosensory 11.23 11.05 177 1393302 9442 109186378
Rectal cancer 11.20 11.05 84 1393395 3705 109192115
Infected skin ulcer 11.20 11.05 87 1393392 3880 109191940
Papilloma viral infection 11.20 11.05 55 1393424 2083 109193737
Psychiatric symptom 11.19 11.05 69 1393410 9144 109186676
Pancreatitis 11.19 11.05 1020 1392459 92513 109103307
Colon neoplasm 11.19 11.05 32 1393447 930 109194890
Cerebral ischaemia 11.17 11.05 98 1393381 12006 109183814
Isosporiasis 11.17 11.05 13 1393466 181 109195639
Intestinal mucosal atrophy 11.16 11.05 6 1393473 23 109195797
Ewing's sarcoma 11.16 11.05 6 1393473 23 109195797
Callus formation delayed 11.16 11.05 6 1393473 23 109195797
Porokeratosis 11.16 11.05 16 1393463 277 109195543
Mucosal atrophy 11.15 11.05 10 1393469 100 109195720
Hyperpyrexia 11.12 11.05 58 1393421 8011 109187809
JC polyomavirus test positive 11.11 11.05 8 1393471 2339 109193481
Adenomatous polyposis coli 11.10 11.05 17 1393462 313 109195507
Metastases to peritoneum 11.09 11.05 35 1393444 5575 109190245
Muscle strength abnormal 11.08 11.05 19 1393460 386 109195434
Vaginal ulceration 11.07 11.05 16 1393463 279 109195541
Arm amputation 11.06 11.05 12 1393467 154 109195666

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Exposure via father 31.31 30.68 6 102 7 113838

Pharmacologic Action:

SourceCodeDescription
ATC L01BA01 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
ANTIMETABOLITES
Folic acid analogues
ATC L04AX03 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
IMMUNOSUPPRESSANTS
IMMUNOSUPPRESSANTS
Other immunosuppressants
FDA MoA N0000000111 Folic Acid Metabolism Inhibitors
FDA EPC N0000175584 Folate Analog Metabolic Inhibitor
MeSH PA D000020 Abortifacient Agents, Nonsteroidal
MeSH PA D000963 Antimetabolites
MeSH PA D000964 Antimetabolites, Antineoplastic
MeSH PA D000970 Antineoplastic Agents
MeSH PA D003879 Dermatologic Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D005493 Folic Acid Antagonists
MeSH PA D007155 Immunologic Factors
MeSH PA D007166 Immunosuppressive Agents
MeSH PA D012102 Reproductive Control Agents
MeSH PA D018501 Antirheumatic Agents
MeSH PA D019384 Nucleic Acid Synthesis Inhibitors
CHEBI has role CHEBI:22587 antiviral agent
CHEBI has role CHEBI:35221 antimetabolite
CHEBI has role CHEBI:35476 antipsychotic agent
CHEBI has role CHEBI:35554 cardiovascular drug
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35705 immunosuppressive agent
CHEBI has role CHEBI:35842 antirheumatic drug
CHEBI has role CHEBI:35845 gout suppressant
CHEBI has role CHEBI:38068 antimalarial
CHEBI has role CHEBI:50177 dermatologic drug
CHEBI has role CHEBI:50683 EC 1.5.1.3 (dihydrofolate reductase) inhibitor
CHEBI has role CHEBI:50691 abortifacient
CHEBI has role CHEBI:50748 antipsoriatic
CHEBI has role CHEBI:59517 DNA synthesis inhibitor
CHEBI has role CHEBI:64946 anti-HIV agent
CHEBI has role CHEBI:65023 anti-asthmatic agent
CHEBI has role CHEBI:66981 ophthalmology drug
CHEBI has role CHEBI:67079 anti-inflammatory agent
CHEBI has role CHEBI:75835 anti-anaemic agent
CHEBI has role CHEBI:233423 antifibrotic agent

Related Drugs by ATC class:

L01BA Folic acid analogues 3 drugs
pemetrexedpralatrexateraltitrexed
L04AX Other immunosuppressants 8 drugs
azathioprinedimethyl fumaratediroximel fumaratelenalidomidepirfenidonepomalidomidetegomil fumaratethalidomide

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Psoriasis indication 9014002 DOID:8893
Crohn's disease indication 34000006
Rheumatoid arthritis indication 69896004 DOID:7148
Acute lymphoid leukemia indication 91857003 DOID:9952
Non-Hodgkin's lymphoma indication 118601006
Burkitt's lymphoma indication 118617000
Mycosis fungoides indication 118618005
Psoriatic arthritis indication 156370009 DOID:9008
Plaque psoriasis indication 200965009
Pustular psoriasis indication 200973000
Erythrodermic psoriasis indication 200977004
Malignant tumor of head and/or neck indication 255056009
Osteosarcoma of bone indication 307576001 DOID:3376
Malignant tumor of lung indication 363358000
Juvenile idiopathic arthritis indication 410502007
Juvenile rheumatoid arthritis indication 410795001
Carcinoma of female breast indication 447782002
Gestational trophoblastic neoplasia indication 609519004 DOID:3590
Meningeal Leukemia indication
Polymyositis off-label use 31384009
Vasculitis off-label use 31996006 DOID:865
Psoriasis with arthropathy off-label use 33339001
Systemic lupus erythematosus off-label use 55464009 DOID:9074
Acute myeloid leukemia, disease off-label use 91861009
Acute promyelocytic leukemia, FAB M3 off-label use 110004001
Wegener's granulomatosis off-label use 195353004 DOID:12132
Malignant tumor of urinary bladder off-label use 399326009 DOID:11054
Systemic Dermatomyositis off-label use
Alcoholism contraindication 7200002
Peptic ulcer contraindication 13200003 DOID:750
Dehydration contraindication 34095006
Fibrosis of lung contraindication 51615001 DOID:3770
Acute nephropathy contraindication 58574008
Hepatic failure contraindication 59927004
Stomatitis contraindication 61170000 DOID:9637
Interstitial pneumonia contraindication 64667001
Ulcerative colitis contraindication 64766004 DOID:8577
Leukopenia contraindication 84828003 DOID:615
Kidney disease contraindication 90708001 DOID:557
Disease of liver contraindication 235856003 DOID:409
Anemia contraindication 271737000 DOID:2355
Pregnancy, function contraindication 289908002
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Bone marrow depression contraindication 307762000
Ascites contraindication 389026000
Gastric ulcer contraindication 397825006 DOID:10808
Breastfeeding (mother) contraindication 413712001
Disorder of immune function contraindication 414029004
Pleural Effusions contraindication
Methotrexate Toxicity contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.61 acidic
pKa2 5.15 acidic
pKa3 12.92 acidic
pKa4 5.73 Basic
pKa5 4.51 Basic
pKa6 1.39 Basic
pKa7 0.75 Basic
pKa8 0.08 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
10MG/0.20ML (10MG/0.20ML) RASUVO MEDEXUS N205776 July 10, 2014 RX SOLUTION SUBCUTANEOUS 8664231 June 1, 2029 SUBCUTANEOUS INJECTION OF METHOTREXATE
12.5MG/0.25ML (12.5MG/0.25ML) RASUVO MEDEXUS N205776 July 10, 2014 RX SOLUTION SUBCUTANEOUS 8664231 June 1, 2029 SUBCUTANEOUS INJECTION OF METHOTREXATE
15MG/0.30ML (15MG/0.30ML) RASUVO MEDEXUS N205776 July 10, 2014 RX SOLUTION SUBCUTANEOUS 8664231 June 1, 2029 SUBCUTANEOUS INJECTION OF METHOTREXATE
17.5MG/0.35ML (17.5MG/0.35ML) RASUVO MEDEXUS N205776 July 10, 2014 RX SOLUTION SUBCUTANEOUS 8664231 June 1, 2029 SUBCUTANEOUS INJECTION OF METHOTREXATE
20MG/0.4ML (20MG/0.4ML) RASUVO MEDEXUS N205776 July 10, 2014 RX SOLUTION SUBCUTANEOUS 8664231 June 1, 2029 SUBCUTANEOUS INJECTION OF METHOTREXATE
22.5MG/0.45ML (22.5MG/0.45ML) RASUVO MEDEXUS N205776 July 10, 2014 RX SOLUTION SUBCUTANEOUS 8664231 June 1, 2029 SUBCUTANEOUS INJECTION OF METHOTREXATE
25MG/0.5ML (25MG/0.5ML) RASUVO MEDEXUS N205776 July 10, 2014 RX SOLUTION SUBCUTANEOUS 8664231 June 1, 2029 SUBCUTANEOUS INJECTION OF METHOTREXATE
27.5MG/0.55ML (27.5MG/0.55ML) RASUVO MEDEXUS N205776 July 10, 2014 DISCN SOLUTION SUBCUTANEOUS 8664231 June 1, 2029 SUBCUTANEOUS INJECTION OF METHOTREXATE
30MG/0.6ML (30MG/0.6ML) RASUVO MEDEXUS N205776 July 10, 2014 RX SOLUTION SUBCUTANEOUS 8664231 June 1, 2029 SUBCUTANEOUS INJECTION OF METHOTREXATE
7.5MG/0.15ML (7.5MG/0.15ML) RASUVO MEDEXUS N205776 July 10, 2014 RX SOLUTION SUBCUTANEOUS 8664231 June 1, 2029 SUBCUTANEOUS INJECTION OF METHOTREXATE
10MG/0.4ML (10MG/0.4ML) OTREXUP COSETTE N204824 Oct. 11, 2013 DISCN SOLUTION SUBCUTANEOUS 8480631 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
10MG/0.4ML (10MG/0.4ML) OTREXUP COSETTE N204824 Oct. 11, 2013 DISCN SOLUTION SUBCUTANEOUS 8579865 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
10MG/0.4ML (10MG/0.4ML) OTREXUP COSETTE N204824 Oct. 11, 2013 DISCN SOLUTION SUBCUTANEOUS 8945063 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
10MG/0.4ML (10MG/0.4ML) OTREXUP COSETTE N204824 Oct. 11, 2013 DISCN SOLUTION SUBCUTANEOUS 9421333 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
12.5MG/0.4ML (12.5MG/0.4ML) OTREXUP COSETTE N204824 March 24, 2016 DISCN SOLUTION SUBCUTANEOUS 8480631 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
12.5MG/0.4ML (12.5MG/0.4ML) OTREXUP COSETTE N204824 March 24, 2016 DISCN SOLUTION SUBCUTANEOUS 8579865 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
12.5MG/0.4ML (12.5MG/0.4ML) OTREXUP COSETTE N204824 March 24, 2016 DISCN SOLUTION SUBCUTANEOUS 8945063 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
12.5MG/0.4ML (12.5MG/0.4ML) OTREXUP COSETTE N204824 March 24, 2016 DISCN SOLUTION SUBCUTANEOUS 9421333 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
15MG/0.4ML (15MG/0.4ML) OTREXUP COSETTE N204824 Oct. 11, 2013 DISCN SOLUTION SUBCUTANEOUS 8480631 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
15MG/0.4ML (15MG/0.4ML) OTREXUP COSETTE N204824 Oct. 11, 2013 DISCN SOLUTION SUBCUTANEOUS 8579865 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
15MG/0.4ML (15MG/0.4ML) OTREXUP COSETTE N204824 Oct. 11, 2013 DISCN SOLUTION SUBCUTANEOUS 8945063 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
15MG/0.4ML (15MG/0.4ML) OTREXUP COSETTE N204824 Oct. 11, 2013 DISCN SOLUTION SUBCUTANEOUS 9421333 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
17.5MG/0.4ML (17.5MG/0.4ML) OTREXUP COSETTE N204824 March 24, 2016 DISCN SOLUTION SUBCUTANEOUS 8480631 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
17.5MG/0.4ML (17.5MG/0.4ML) OTREXUP COSETTE N204824 March 24, 2016 DISCN SOLUTION SUBCUTANEOUS 8579865 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
17.5MG/0.4ML (17.5MG/0.4ML) OTREXUP COSETTE N204824 March 24, 2016 DISCN SOLUTION SUBCUTANEOUS 8945063 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
17.5MG/0.4ML (17.5MG/0.4ML) OTREXUP COSETTE N204824 March 24, 2016 DISCN SOLUTION SUBCUTANEOUS 9421333 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
20MG/0.4ML (20MG/0.4ML) OTREXUP COSETTE N204824 Oct. 11, 2013 DISCN SOLUTION SUBCUTANEOUS 8480631 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
20MG/0.4ML (20MG/0.4ML) OTREXUP COSETTE N204824 Oct. 11, 2013 DISCN SOLUTION SUBCUTANEOUS 8579865 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
20MG/0.4ML (20MG/0.4ML) OTREXUP COSETTE N204824 Oct. 11, 2013 DISCN SOLUTION SUBCUTANEOUS 8945063 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
20MG/0.4ML (20MG/0.4ML) OTREXUP COSETTE N204824 Oct. 11, 2013 DISCN SOLUTION SUBCUTANEOUS 9421333 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
22.5MG/0.4ML (22.5MG/0.4ML) OTREXUP COSETTE N204824 March 24, 2016 DISCN SOLUTION SUBCUTANEOUS 8480631 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
22.5MG/0.4ML (22.5MG/0.4ML) OTREXUP COSETTE N204824 March 24, 2016 DISCN SOLUTION SUBCUTANEOUS 8579865 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
22.5MG/0.4ML (22.5MG/0.4ML) OTREXUP COSETTE N204824 March 24, 2016 DISCN SOLUTION SUBCUTANEOUS 8945063 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
22.5MG/0.4ML (22.5MG/0.4ML) OTREXUP COSETTE N204824 March 24, 2016 DISCN SOLUTION SUBCUTANEOUS 9421333 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
25MG/0.4ML (25MG/0.4ML) OTREXUP COSETTE N204824 Oct. 11, 2013 DISCN SOLUTION SUBCUTANEOUS 8480631 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
25MG/0.4ML (25MG/0.4ML) OTREXUP COSETTE N204824 Oct. 11, 2013 DISCN SOLUTION SUBCUTANEOUS 8579865 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
25MG/0.4ML (25MG/0.4ML) OTREXUP COSETTE N204824 Oct. 11, 2013 DISCN SOLUTION SUBCUTANEOUS 8945063 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
25MG/0.4ML (25MG/0.4ML) OTREXUP COSETTE N204824 Oct. 11, 2013 DISCN SOLUTION SUBCUTANEOUS 9421333 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
7.5MG/0.4ML (7.5MG/0.4ML) OTREXUP COSETTE N204824 Nov. 7, 2014 DISCN SOLUTION SUBCUTANEOUS 8480631 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
7.5MG/0.4ML (7.5MG/0.4ML) OTREXUP COSETTE N204824 Nov. 7, 2014 DISCN SOLUTION SUBCUTANEOUS 8579865 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
7.5MG/0.4ML (7.5MG/0.4ML) OTREXUP COSETTE N204824 Nov. 7, 2014 DISCN SOLUTION SUBCUTANEOUS 8945063 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
7.5MG/0.4ML (7.5MG/0.4ML) OTREXUP COSETTE N204824 Nov. 7, 2014 DISCN SOLUTION SUBCUTANEOUS 9421333 March 19, 2030 SUBCUTANEOUS INJECTION OF METHOTREXATE
EQ 2.5MG BASE/ML XATMEP AZURITY N208400 April 25, 2017 RX SOLUTION ORAL 10231927 Jan. 2, 2033 A METHOD FOR TREATING ACUTE LYMPHOBLASTIC LEUKEMIA
EQ 2.5MG BASE/ML XATMEP AZURITY N208400 April 25, 2017 RX SOLUTION ORAL 10231927 Jan. 2, 2033 TREATMENT OF JUVENILE RHEUMATOID ARTHRITIS
EQ 2.5MG BASE/ML XATMEP AZURITY N208400 April 25, 2017 RX SOLUTION ORAL 11116724 Jan. 2, 2033 A METHOD FOR TREATING ACUTE LYMPHOBLASTIC LEUKEMIA
EQ 2.5MG BASE/ML XATMEP AZURITY N208400 April 25, 2017 RX SOLUTION ORAL 11116724 Jan. 2, 2033 TREATMENT OF JUVENILE RHEUMATOID ARTHRITIS
2MG/ML JYLAMVO SHORLA N212479 Nov. 29, 2022 RX SOLUTION ORAL 11771701 Oct. 29, 2034 TREATMENT OF ADULTS WITH ACUTE LYMPHOBLASTIC LEUKEMIA WITH AN ORAL SOLUTION OF METHOTREXATE
2MG/ML JYLAMVO SHORLA N212479 Nov. 29, 2022 RX SOLUTION ORAL 11771701 Oct. 29, 2034 TREATMENT OF ADULTS WITH MYCOSIS FUNGOIDES WITH AN ORAL SOLUTION OF METHOTREXATE
2MG/ML JYLAMVO SHORLA N212479 Nov. 29, 2022 RX SOLUTION ORAL 11771701 Oct. 29, 2034 TREATMENT OF ADULTS WITH RELAPSED OR REFRACTORY NON-HODGKIN LYMPHOMAS WITH AN ORAL SOLUTION OF METHOTREXATE
2MG/ML JYLAMVO SHORLA N212479 Nov. 29, 2022 RX SOLUTION ORAL 11771701 Oct. 29, 2034 TREATMENT OF ADULTS WITH RHEUMATOID ARTHRITIS WITH AN ORAL SOLUTION OF METHOTREXATE
2MG/ML JYLAMVO SHORLA N212479 Nov. 29, 2022 RX SOLUTION ORAL 11771701 Oct. 29, 2034 TREATMENT OF ADULTS WITH SEVERE PSORIASIS WITH AN ORAL SOLUTION OF METHOTREXATE

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Dihydrofolate reductase Enzyme INHIBITOR Ki 8.92 IUPHAR DRUG LABEL
Canalicular multispecific organic anion transporter 1 Transporter WOMBAT-PK
Multidrug resistance-associated protein 1 Transporter WOMBAT-PK
ATP-binding cassette sub-family G member 2 Transporter WOMBAT-PK
Thymidylate synthase Enzyme Ki 6.22 CHEMBL
Multidrug resistance-associated protein 5 Transporter WOMBAT-PK
Folylpolyglutamate synthase, mitochondrial Enzyme IC50 5.49 CHEMBL
Multidrug resistance-associated protein 4 Transporter WOMBAT-PK
Folate receptor beta Membrane receptor IC50 6.97 CHEMBL
Proton-coupled folate transporter Transporter IC50 6.92 CHEMBL
Multidrug resistance protein 1 Transporter WOMBAT-PK
Toll-like receptor 4 Membrane receptor IC50 5.98 CHEMBL
Folate transporter 1 Transporter Ki 5.46 CHEMBL
Folate receptor alpha Membrane receptor IC50 6.94 CHEMBL
High mobility group protein B1 Nuclear other Kd 7.62 CHEMBL
Serine hydroxymethyltransferase, mitochondrial Enzyme Ki 4.01 CHEMBL
Bifunctional purine biosynthesis protein PURH Enzyme Ki 6.06 CHEMBL
Bifunctional dihydrofolate reductase-thymidylate synthase Enzyme IC50 8.85 CHEMBL
Dihydrofolate reductase Enzyme IC50 9 CHEMBL
Bifunctional dihydrofolate reductase-thymidylate synthase Enzyme IC50 7.08 CHEMBL
Dihydrofolate reductase Enzyme Ki 5.41 CHEMBL
Dihydrofolate reductase Enzyme Ki 10.14 CHEMBL
Dihydrofolate reductase Enzyme Ki 10.68 CHEMBL
Dihydrofolate reductase Enzyme IC50 8.89 CHEMBL
Thymidylate synthase Enzyme Ki 4.35 CHEMBL
Dihydrofolate reductase Enzyme IC50 7.72 CHEMBL
Thymidylate synthase Enzyme IC50 4.40 CHEMBL
Dihydrofolate reductase Enzyme Ki 10.68 CHEMBL
Thymidylate synthase Enzyme IC50 5.74 CHEMBL
Pteridine reductase 1 Enzyme Ki 7.41 CHEMBL
Bifunctional dihydrofolate reductase-thymidylate synthase Enzyme IC50 6.96 CHEMBL
Dihydrofolate reductase Enzyme Ki 9 CHEMBL
Dihydrofolate reductase Enzyme IC50 8.08 CHEMBL
Dihydrofolate reductase Enzyme IC50 7.91 CHEMBL
Dihydrofolate reductase Enzyme IC50 8.77 CHEMBL
Dihydrofolate reductase Enzyme IC50 8.85 CHEMBL
Bifunctional dihydrofolate reductase-thymidylate synthase Enzyme Ki 9.89 CHEMBL

External reference:

IDSource
4019828 VUID
N0000147916 NUI
D00142 KEGG_DRUG
7413-34-5 SECONDARY_CAS_RN
4017903 VANDF
4019828 VANDF
C0025677 UMLSCUI
CHEBI:44185 CHEBI
MTX PDB_CHEM_ID
CHEMBL34259 ChEMBL_ID
CHEMBL3244648 ChEMBL_ID
D008727 MESH_DESCRIPTOR_UI
DB00563 DRUGBANK_ID
4815 IUPHAR_LIGAND_ID
926 INN_ID
YL5FZ2Y5U1 UNII
126941 PUBCHEM_CID
287734 RXNORM
12261 MMSL
30391 MMSL
5077 MMSL
6313 MMSL
73119 MMSL
d00060 MMSL
002644 NDDF
002645 NDDF
387381009 SNOMEDCT_US
412247000 SNOMEDCT_US
68887009 SNOMEDCT_US
YL5FZ2Y5U1 INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Methotrexate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0054-4550 TABLET 2.50 mg ORAL ANDA 28 sections
Methotrexate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0054-8550 TABLET 2.50 mg ORAL ANDA 28 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 0143-9367 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 1 g INTRA-ARTERIAL ANDA 23 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 0143-9516 SOLUTION 25 mg INTRA-ARTERIAL ANDA 33 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 0143-9517 SOLUTION 25 mg INTRA-ARTERIAL ANDA 33 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 0143-9518 SOLUTION 25 mg INTRA-ARTERIAL ANDA 33 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 0143-9519 SOLUTION 25 mg INTRA-ARTERIAL ANDA 33 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 0143-9830 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 1 g INTRA-ARTERIAL ANDA 27 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 0378-0014 TABLET 2.50 mg ORAL ANDA 29 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 0555-0572 TABLET 2.50 mg ORAL ANDA 28 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 0555-0572 TABLET 2.50 mg ORAL ANDA 28 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 0703-3671 INJECTION, SOLUTION 25 mg INTRA-ARTERIAL ANDA 28 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 0703-3675 INJECTION, SOLUTION 25 mg INTRA-ARTERIAL ANDA 28 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 0703-3678 INJECTION, SOLUTION 25 mg INTRA-ARTERIAL ANDA 28 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 0904-7141 TABLET 2.50 mg ORAL ANDA 25 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 16729-277 INJECTION 25 mg INTRA-ARTERIAL ANDA 29 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 16729-486 TABLET 2.50 mg ORAL ANDA 30 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 16729-486 TABLET 2.50 mg ORAL ANDA 30 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 42291-594 TABLET 2.50 mg ORAL ANDA 17 sections
METHOTREXATE Human Prescription Drug Label 1 46708-711 INJECTION, SOLUTION 25 mg INTRAMUSCULAR ANDA 28 sections
METHOTREXATE Human Prescription Drug Label 1 46708-712 INJECTION, SOLUTION 25 mg INTRAMUSCULAR ANDA 28 sections
METHOTREXATE Human Prescription Drug Label 1 46708-730 TABLET 2.50 mg ORAL ANDA 27 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 47335-235 TABLET 2.50 mg ORAL ANDA 30 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 48433-065 TABLET 2.50 mg ORAL ANDA 28 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 50090-2345 TABLET 2.50 mg ORAL ANDA 26 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 50090-5457 TABLET 2.50 mg ORAL ANDA 27 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 50268-554 TABLET 2.50 mg ORAL ANDA 26 sections
Methotrexate HUMAN PRESCRIPTION DRUG LABEL 1 51079-670 TABLET 2.50 mg ORAL ANDA 28 sections
Trexall HUMAN PRESCRIPTION DRUG LABEL 1 51285-366 TABLET, FILM COATED 5 mg ORAL ANDA 28 sections
Trexall HUMAN PRESCRIPTION DRUG LABEL 1 51285-367 TABLET, FILM COATED 7.50 mg ORAL ANDA 28 sections