pomalidomide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
antineoplastics, thalidomide derivatives 4746 19171-19-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • pomalyst
  • actimid
  • pomalidomide
an immunomodulator with antineoplastic and angiogenesis inhibitor activity
  • Molecular weight: 273.25
  • Formula: C13H11N3O4
  • CLOGP: -0.19
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 2
  • TPSA: 109.57
  • ALOGS: -2.03
  • ROTB: 1
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
3 mg O

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 0.371 Moderate 0.67
caco2-efflux Caco-2 efflux ratio (BA/AB) 2.979 Moderate 0.67
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 31.189 10^-6 cm/s Moderate 0.67
dh-clint Dog hepatocyte intrinsic clearance 2.506 uL/min/10^6 cells Moderate 0.67
dppb Dog plasma protein binding (% unbound) 80.690 % Moderate 0.67
fcs-ppb Fetal calf serum protein binding (% unbound) 71.900 % Moderate 0.67
herg hERG pIC50 4.267 pIC50 Moderate 0.67
hh-clint Human hepatocyte intrinsic clearance 2.118 uL/min/10^6 cells Moderate 0.67
hlm-clint Human liver microsomal intrinsic clearance 3.013 uL/min/mg protein Moderate 0.67
hppb Human plasma protein binding (% unbound) 77.930 % Moderate 0.67
kinase-safety-class ACVR2A,ACVR2B,ACVRL1,ALK,AURKA,AURKB,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK1,CDK5,CDK9,CHEK1,CSF1R,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GSK3B,IKBKB,IRAK1,ITK,JAK1,JAK2,KIT,MAP2K6,MAP3K1,MAP3K10,MAP3K11,MAP3K21,MAP3K7,MAP4K1,MAP4K3,MAPK10,MAPK12,MAPK7,MAPK9,MARK4,MELK,MET,MTOR,NTRK2,PAK4,PDK1,PDK2,PDK4,PDPK1,PIK3CB,PIK3CD,PIM2,PLK1,PLK4,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TTK,ULK1,ULK2 67
kinase-selectivity-class ACVR2A,ACVR2B,ALK,AURKA,AURKB,AURKC,AXL,BRAF,CAMK2B,CAMK2D,CDK16,CDK4,CDK9,CLK4,DDR1,DYRK1B,EIF2AK3,ERBB2,FLT3,GRK2,GSK3A,GSK3B,HASPIN,INSR,IRAK1,IRAK3,JAK2,MAP2K3,MAP2K6,MAP3K11,MAP3K14,MAP3K21,MAP3K7,MAP4K1,MAPK1,MAPK12,MAPK7,MAPK8,MARK4,MET,MINK1,MTOR,NTRK3,PAK4,PDK1,PIK3CB,PIM3,PRKAA1,PRKDC,SGK1,SIK2,SIK3,STK10,STK17A,STK33,STK4,SYK,TEK,TNIK,TTK,TYRO3,UHMK1,ULK1,ULK2 64
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 1.841 Moderate 0.74
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 5.093 Moderate 0.67
mh-clint Mouse hepatocyte intrinsic clearance 1.531 Moderate 0.67
mppb Mouse plasma protein binding (% unbound) 82.080 Moderate 0.67
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 7.096 Moderate 0.67
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pld-class Phospholipidosis risk class (1 = positive, 0 = negative) 0 Moderate 0.74
pppb Pig plasma protein binding (% unbound) 79.740 % Moderate 0.67
rat-kpuu-brain Rat brain Kpuu 0.402 % Moderate 0.74
rh-clint Rat hepatocyte intrinsic clearance 1.493 uL/min/10^6 cells Moderate 0.67
rh-fuinc Rat hepatocyte fraction unbound in incubation 92.430 % Moderate 0.67
rppb Rat plasma protein binding (% unbound) 66.310 % Moderate 0.67
solubility-dd Solubility at pH 7.4 in DMSO 232.274 uM Moderate 0.67

Approvals:

DateAgencyCompanyOrphan
March 26, 2015 PMDA CELGENE K.K.
Feb. 8, 2013 FDA CELGENE

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Death 2935.39 21.68 2630 70753 453921 90101143
White blood cell count decreased 1933.34 21.68 1364 72019 165745 90389319
Full blood count decreased 1710.83 21.68 707 72676 28982 90526082
Neutropenia 1509.65 21.68 1332 72051 223572 90331492
Pneumonia 1481.23 21.68 2171 71212 635888 89919176
Neuropathy peripheral 1293.33 21.68 990 72393 135980 90419084
Laboratory test abnormal 835.55 21.68 483 72900 41371 90513693
Fatigue 712.63 21.68 2293 71090 1151730 89403334
Constipation 558.63 21.68 892 72491 279503 90275561
Platelet count decreased 549.39 21.68 614 72769 136355 90418709
Neutrophil count decreased 545.99 21.68 457 72926 71075 90483989
Thrombosis 542.68 21.68 460 72923 72791 90482273
Plasma cell myeloma recurrent 485.79 21.68 167 73216 4061 90551003
Unevaluable event 417.60 21.68 350 73033 54498 90500566
Plasmacytoma 335.25 21.68 114 73269 2679 90552385
Human chorionic gonadotropin increased 325.01 21.68 102 73281 1844 90553220
Influenza 321.72 21.68 475 72908 138789 90416275
Plasma cell myeloma 307.57 21.68 259 73124 40569 90514495
COVID-19 303.07 21.68 513 72870 168330 90386734
Cytopenia 274.68 21.68 173 73210 17276 90537788
Rheumatoid arthritis 268.82 21.68 5 73378 362609 90192455
Condition aggravated 259.62 21.68 80 73303 595465 89959599
Tremor 244.42 21.68 442 72941 152731 90402333
Urinary tract infection 232.12 21.68 656 72727 304976 90250088
Adverse drug reaction 221.89 21.68 364 73019 116337 90438727
Product dose omission issue 218.48 21.68 623 72760 291064 90264000
Anaemia 216.93 21.68 703 72680 352099 90202965
Diarrhoea 213.38 21.68 1393 71990 937797 89617267
Pericarditis 187.96 21.68 7 73376 270144 90284920
Bronchitis 181.74 21.68 390 72993 152537 90402527
Muscle spasms 180.82 21.68 530 72853 251353 90303711
Infusion related reaction 179.64 21.68 57 73326 416723 90138341
Glossodynia 177.33 21.68 25 73358 321754 90233310
Light chain analysis increased 172.86 21.68 60 73323 1502 90553562
Asthenia 169.38 21.68 866 72517 532885 90022179
Thrombocytopenia 169.17 21.68 459 72924 208266 90346798
Helicobacter infection 164.60 21.68 4 73379 226846 90328218
Drug hypersensitivity 163.23 21.68 86 73297 463523 90091541
Wound 159.07 21.68 27 73356 302953 90252111
Atrial fibrillation 159.03 21.68 341 73042 133270 90421794
Cardiac disorder 150.35 21.68 207 73176 56665 90498399
Sepsis 146.25 21.68 396 72987 179418 90375646
Plasma cell myeloma refractory 146.20 21.68 48 73335 1008 90554056
Renal disorder 143.50 21.68 165 73218 37694 90517370
Folliculitis 143.15 21.68 5 73378 204348 90350716
Fibromyalgia 141.24 21.68 6 73377 206263 90348801
Impaired healing 139.36 21.68 14 73369 234185 90320879
Hepatic enzyme increased 135.92 21.68 61 73322 360675 90194389
Drug interaction 135.84 21.68 29 73354 276424 90278640
Back pain 134.00 21.68 560 72823 316615 90238449
Product use in unapproved indication 132.85 21.68 53 73330 336183 90218881
Mobility decreased 132.36 21.68 22 73361 250712 90304352
Treatment failure 130.12 21.68 42 73341 303886 90251178
Haemoglobin decreased 129.02 21.68 354 73029 161602 90393462
Injection site pain 126.23 21.68 3 73380 173696 90381368
Red blood cell count decreased 125.97 21.68 171 73212 46180 90508884
Liver injury 123.75 21.68 3 73380 170564 90384500
Therapeutic product effect decreased 123.06 21.68 36 73347 277535 90277529
Discomfort 119.05 21.68 37 73346 274298 90280766
Full blood count increased 115.57 21.68 42 73341 1206 90553858
Peripheral swelling 114.34 21.68 646 72737 412460 90142604
Nasopharyngitis 114.26 21.68 639 72744 406465 90148599
Product use issue 111.97 21.68 64 73319 329855 90225209
Emergency care examination 111.82 21.68 26 73357 135 90554929
Hospitalisation 111.09 21.68 289 73094 127811 90427253
Arthralgia 109.87 21.68 298 73085 778224 89776840
Dizziness 108.05 21.68 831 72552 588453 89966611
Irritable bowel syndrome 105.56 21.68 20 73363 207428 90347636
Bone pain 104.06 21.68 183 73200 61800 90493264
Deep vein thrombosis 103.47 21.68 229 73154 91391 90463673
Fall 102.97 21.68 705 72678 481105 90073959
Injury 102.63 21.68 18 73365 197331 90357733
Renal failure 101.98 21.68 284 73099 130723 90424341
Musculoskeletal stiffness 99.94 21.68 58 73325 296474 90258590
Hip fracture 99.08 21.68 128 73255 32949 90522115
Wheezing 98.23 21.68 35 73348 238045 90317019
Rash 96.47 21.68 1026 72357 795074 89759990
Psoriasis 92.86 21.68 7 73376 147747 90407317
Osteoarthritis 91.22 21.68 23 73360 195707 90359357
Tooth disorder 91.08 21.68 119 73264 30971 90524093
Respiratory syncytial virus infection 90.47 21.68 72 73311 10408 90544656
Abdominal pain 87.87 21.68 115 73268 395606 90159458
Osteolysis 87.22 21.68 47 73336 3503 90551561
Drug ineffective 85.56 21.68 715 72668 1383583 89171481
Overdose 85.09 21.68 13 73370 157696 90397368
Cataract 84.58 21.68 183 73200 71909 90483155
Pulmonary thrombosis 84.00 21.68 67 73316 9715 90545349
COVID-19 pneumonia 82.34 21.68 87 73296 18090 90536974
Full blood count abnormal 80.34 21.68 122 73261 36475 90518589
Blood cholesterol increased 80.15 21.68 34 73349 207978 90347086
Abdominal discomfort 78.85 21.68 168 73215 477160 90077904
Inflammation 77.60 21.68 24 73359 178568 90376496
Hypercalcaemia 69.37 21.68 110 73273 34130 90520934
Lip dry 68.87 21.68 3 73380 100952 90454112
Blister 68.83 21.68 63 73320 254935 90300129
Bursitis 68.45 21.68 12 73371 131642 90423422
Ill-defined disorder 68.43 21.68 32 73351 184859 90370205
Cerebrovascular accident 67.60 21.68 237 73146 123296 90431768
Arthropathy 66.40 21.68 122 73261 366120 90188944
Illness 66.04 21.68 180 73203 81789 90473275
Therapeutic product effect incomplete 65.19 21.68 38 73345 193858 90361206
Pulmonary fibrosis 65.04 21.68 6 73377 107497 90447567
Sleep disorder 63.53 21.68 41 73342 197989 90357075
Immune system disorder 63.06 21.68 62 73321 11843 90543221
Pain 63.01 21.68 511 72872 995830 89559234
Grip strength decreased 62.34 21.68 3 73380 92573 90462491
Injection site reaction 61.95 21.68 3 73380 92077 90462987
Product distribution issue 61.49 21.68 38 73345 3667 90551397
Musculoskeletal pain 59.82 21.68 32 73351 171219 90383845
Blood test abnormal 59.52 21.68 79 73304 20873 90534191
Hypersensitivity 56.77 21.68 184 73199 454493 90100571
Migraine 56.34 21.68 43 73340 190349 90364715
Infection 55.63 21.68 491 72892 361603 90193461
Swelling 55.56 21.68 165 73218 418893 90136171
Pancytopenia 55.16 21.68 218 73165 120045 90435019
Bone lesion 55.08 21.68 44 73339 6393 90548671
Crystal nephropathy 54.90 21.68 24 73359 1127 90553937
Plasma cell leukaemia 54.76 21.68 24 73359 1134 90553930
Headache 54.71 21.68 442 72941 862304 89692760
Respiratory tract infection 53.99 21.68 136 73247 58942 90496122
Dyspnoea 52.74 21.68 1003 72380 879952 89675112
Blood calcium increased 51.59 21.68 56 73327 12002 90543062
Epilepsy 51.34 21.68 4 73379 82202 90472862
Hypertension 51.18 21.68 194 73189 457338 90097726
Wound infection 50.54 21.68 12 73371 106390 90448674
Monoclonal immunoglobulin increased 49.80 21.68 17 73366 404 90554660
Protein total increased 48.33 21.68 32 73351 3477 90551587
Feeling abnormal 47.78 21.68 264 73119 166971 90388093
Vision blurred 47.45 21.68 196 73187 110097 90444967
Blood potassium decreased 46.93 21.68 113 73270 47614 90507450
Product quality issue 46.49 21.68 5 73378 79320 90475744
Wrong technique in product usage process 46.09 21.68 3 73380 71568 90483496
Multiple allergies 45.96 21.68 59 73324 15087 90539977
Paraproteinaemia 45.13 21.68 14 73369 243 90554821
Bone marrow disorder 45.07 21.68 29 73354 3003 90552061
Vomiting 44.54 21.68 416 72967 787877 89767187
General physical health deterioration 44.10 21.68 144 73239 354971 90200093
Dehydration 44.09 21.68 289 73094 194158 90360906
Tooth infection 43.93 21.68 67 73316 20103 90534961
Medication error 43.39 21.68 8 73375 84644 90470420
Anaphylactic reaction 43.32 21.68 9 73374 87515 90467549
C-reactive protein increased 43.06 21.68 50 73333 181339 90373725
Seasonal allergy 42.70 21.68 71 73312 22912 90532152
Anxiety 42.47 21.68 120 73263 309652 90245412
Balance disorder 42.14 21.68 173 73210 96907 90458157
Diverticulitis 41.26 21.68 104 73279 45083 90509981
Febrile neutropenia 40.67 21.68 243 73140 158106 90396958
Light chain analysis abnormal 40.56 21.68 12 73371 176 90554888
Nervousness 40.56 21.68 87 73296 33969 90521095
Pneumonia influenzal 39.80 21.68 24 73359 2216 90552848
Coronavirus infection 39.49 21.68 34 73349 5481 90549583
Intentional product misuse 38.99 21.68 12 73371 89592 90465472
Loss of personal independence in daily activities 38.68 21.68 32 73351 136073 90418991
Asthma 38.46 21.68 87 73296 242073 90312991
Progressive multifocal leukoencephalopathy 38.41 21.68 55 73328 15600 90539464
White blood cell count abnormal 37.75 21.68 38 73345 7466 90547598
Spinal fracture 36.93 21.68 65 73318 21951 90533113
Swelling face 36.12 21.68 146 73237 81206 90473858
Inappropriate schedule of product administration 35.94 21.68 41 73342 149892 90405172
Leukopenia 35.75 21.68 169 73214 100541 90454523
Pneumonia pneumococcal 35.67 21.68 24 73359 2678 90552386
Rash pruritic 35.28 21.68 146 73237 82068 90472996
Osteoporosis 35.25 21.68 17 73366 96514 90458550
Lower respiratory tract infection 35.17 21.68 96 73287 250563 90304501
Neutrophil count abnormal 34.86 21.68 28 73355 4100 90550964
Localised infection 34.66 21.68 81 73302 33481 90521583
Injection site swelling 34.49 21.68 4 73379 59835 90495229
Pulmonary embolism 34.39 21.68 202 73181 130618 90424446
Foot deformity 34.35 21.68 4 73379 59647 90495417
Viral infection 33.40 21.68 91 73292 41323 90513741
Coma 32.93 21.68 9 73374 72623 90482441
Drug ineffective for unapproved indication 32.68 21.68 7 73376 66637 90488427
Liver disorder 32.65 21.68 30 73353 121239 90433825
Urticaria 32.16 21.68 137 73246 312597 90242467
Pneumonia parainfluenzae viral 32.15 21.68 12 73371 372 90554692
Therapy interrupted 31.71 21.68 101 73282 50007 90505057
Nail disorder 31.55 21.68 5 73378 59062 90496002
Hypogammaglobulinaemia 31.48 21.68 41 73342 10633 90544431
Cystitis 31.44 21.68 122 73261 66596 90488468
Road traffic accident 30.96 21.68 25 73358 107601 90447463
Disease progression 30.89 21.68 225 73158 156390 90398674
Rib fracture 30.87 21.68 67 73316 26368 90528696
Malaise 30.56 21.68 654 72729 585332 89969732
Colitis ulcerative 30.24 21.68 6 73377 60260 90494804
Exostosis 29.53 21.68 4 73379 53130 90501934
Aspartate aminotransferase increased 29.49 21.68 24 73359 102913 90452151
Metabolic acidosis 29.10 21.68 5 73378 55671 90499393
Cardiac failure congestive 28.98 21.68 157 73226 98537 90456527
Injection site bruising 28.93 21.68 4 73379 52303 90502761
Monoclonal immunoglobulin present 28.36 21.68 19 73364 2105 90552959
Pathological fracture 28.33 21.68 37 73346 9623 90545441
Adverse event 28.12 21.68 177 73206 117241 90437823
Joint stiffness 28.11 21.68 14 73369 78028 90477036
Natural killer cell count decreased 27.86 21.68 8 73375 105 90554959
Dry skin 27.84 21.68 143 73240 87930 90467134
Stomatitis 27.83 21.68 121 73262 274577 90280487
SARS-CoV-2 test positive 27.16 21.68 39 73344 11089 90543975
Onychomadesis 26.70 21.68 3 73380 45995 90509069
Alanine aminotransferase increased 26.62 21.68 34 73349 118304 90436760
Off label use 26.47 21.68 1117 72266 1101135 89453929
Peripheral sensory neuropathy 26.46 21.68 35 73348 9215 90545849
Febrile infection 26.42 21.68 18 73365 2051 90553013
Sciatica 26.22 21.68 26 73357 101356 90453708
Myelosuppression 26.07 21.68 99 73284 53492 90501572
Neutropenic sepsis 25.97 21.68 50 73333 18080 90536984
JC virus CSF test positive 25.36 21.68 6 73377 34 90555030
Feeling jittery 25.29 21.68 45 73338 15326 90539738
Eye infection 25.10 21.68 43 73340 14211 90540853
Prescribed underdose 24.78 21.68 15 73368 75004 90480060
Compression fracture 24.75 21.68 33 73350 8756 90546308
Weight decreased 24.74 21.68 193 73190 379717 90175347
Gastric disorder 24.61 21.68 71 73312 33313 90521751
Stress 24.56 21.68 18 73365 81377 90473687
Depression 24.41 21.68 143 73240 300458 90254606
Incorrect dose administered 24.41 21.68 17 73366 78913 90476151
Musculoskeletal chest pain 24.17 21.68 57 73326 23693 90531371
Suicidal ideation 24.07 21.68 15 73368 73840 90481224
Kidney infection 24.03 21.68 60 73323 25856 90529208
Accidental exposure to product 24.00 21.68 3 73380 42363 90512701
Tachycardia 23.94 21.68 58 73325 157615 90397449
Eye disorder 23.93 21.68 62 73321 27328 90527736
Plasma cells increased 23.70 21.68 7 73376 102 90554962
Peritonitis viral 23.57 21.68 6 73377 48 90555016
Surgery 23.53 21.68 4 73379 44883 90510181
Depressed level of consciousness 23.42 21.68 15 73368 72769 90482295
Sleep disorder due to a general medical condition 23.42 21.68 4 73379 44734 90510330
Hepatic cirrhosis 23.31 21.68 11 73372 63242 90491822
Upper limb fracture 23.29 21.68 53 73330 21525 90533539
Night sweats 23.20 21.68 43 73340 128723 90426341
Clostridium difficile infection 22.88 21.68 73 73310 36172 90518892
Angioedema 22.82 21.68 12 73371 64864 90490200
Tumour lysis syndrome 22.82 21.68 36 73347 11116 90543948
Agitation 22.75 21.68 13 73370 67085 90487979
Rhinovirus infection 22.61 21.68 26 73357 5937 90549127
Weight increased 22.49 21.68 223 73160 417704 90137360
Delirium 22.43 21.68 31 73352 104328 90450736
Hypoaesthesia oral 22.31 21.68 43 73340 15557 90539507
Atrial rupture 22.20 21.68 6 73377 62 90555002
Jugular vein occlusion 22.12 21.68 6 73377 63 90555001
Drug reaction with eosinophilia and systemic symptoms 22.00 21.68 4 73379 42754 90512310
Hyponatraemia 21.99 21.68 47 73336 133491 90421573
Respiratory tract infection viral 21.99 21.68 19 73364 3077 90551987
Dementia 21.87 21.68 55 73328 23806 90531258
Sedation 21.78 21.68 6 73377 48165 90506899
Upper respiratory tract infection 21.76 21.68 178 73205 128140 90426924
Dysphonia 21.76 21.68 105 73278 62979 90492085
Blood pressure systolic increased 21.73 21.68 10 73373 58335 90496729

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Death 2644.38 17.89 3632 70631 467553 42079519
Pneumonia 1855.91 17.89 2907 71356 419242 42127830
White blood cell count decreased 1386.63 17.89 1301 72962 109095 42437977
Full blood count decreased 1191.54 17.89 622 73641 19938 42527134
Fatigue 1091.35 17.89 2358 71905 433283 42113789
Laboratory test abnormal 854.89 17.89 520 73743 22458 42524614
Neutropenia 837.82 17.89 1351 72912 198080 42348992
Neuropathy peripheral 810.15 17.89 941 73322 100912 42446160
Adverse drug reaction 469.94 17.89 442 73821 36992 42510080
Influenza 441.87 17.89 543 73720 61632 42485440
Unevaluable event 415.38 17.89 397 73866 33891 42513181
Drug interaction 377.41 17.89 22 74241 266977 42280095
Plasma cell myeloma recurrent 376.17 17.89 189 74074 5568 42541504
Thrombosis 358.32 17.89 515 73748 67996 42479076
Peripheral swelling 345.91 17.89 588 73675 89682 42457390
COVID-19 331.95 17.89 666 73597 115282 42431790
Rash 322.06 17.89 1136 73127 275818 42271254
Neutrophil count decreased 308.83 17.89 461 73802 62954 42484118
Constipation 299.97 17.89 784 73479 161507 42385565
Platelet count decreased 271.00 17.89 684 73579 137897 42409175
Nasopharyngitis 239.62 17.89 482 73781 83514 42463558
Plasmacytoma 232.66 17.89 125 74138 4239 42542833
Infection 225.11 17.89 559 73704 111509 42435563
Muscle spasms 211.94 17.89 465 73798 85579 42461493
Condition aggravated 202.30 17.89 101 74162 260653 42286419
Adverse event 181.67 17.89 215 74048 23425 42523647
Product use in unapproved indication 175.17 17.89 52 74211 184404 42362668
Cardiac disorder 174.48 17.89 309 73954 48623 42498449
Plasma cell myeloma refractory 166.96 17.89 70 74193 1340 42545732
Plasma cell myeloma 160.12 17.89 293 73970 47285 42499787
Completed suicide 153.19 17.89 3 74260 96462 42450610
Renal disorder 153.00 17.89 219 74044 28761 42518311
Asthenia 148.95 17.89 916 73347 279877 42267195
Back pain 144.37 17.89 558 73705 141218 42405854
Tooth disorder 141.74 17.89 137 74126 11842 42535230
Overdose 141.66 17.89 11 74252 105253 42441819
Illness 126.64 17.89 185 74078 24745 42522327
Hospitalisation 122.85 17.89 345 73918 73985 42473087
Deep vein thrombosis 118.29 17.89 348 73915 76609 42470463
Hyponatraemia 113.37 17.89 20 74243 101442 42445630
Plasma cell leukaemia 106.13 17.89 49 74214 1191 42545881
Product dose omission issue 105.14 17.89 539 73724 153826 42393246
Light chain analysis increased 99.61 17.89 53 74210 1761 42545311
Sepsis 99.08 17.89 640 73623 198694 42348378
Emergency care examination 98.43 17.89 21 74242 20 42547052
Bronchitis 98.37 17.89 239 74024 46962 42500110
Rhabdomyolysis 94.92 17.89 12 74251 78007 42469065
Abdominal pain 94.25 17.89 116 74147 190355 42356717
Localised infection 93.23 17.89 144 74119 20229 42526843
Cytopenia 92.00 17.89 132 74131 17365 42529707
Atrial fibrillation 85.18 17.89 473 73790 139120 42407952
Bone pain 84.44 17.89 150 74113 23642 42523430
Monoclonal immunoglobulin present 83.25 17.89 41 74222 1155 42545917
Vomiting 83.15 17.89 245 74018 289478 42257594
Immune system disorder 82.80 17.89 75 74188 5969 42541103
Toxicity to various agents 81.91 17.89 173 74090 228963 42318109
Injection site pain 77.84 17.89 6 74257 57792 42489280
Drug intolerance 74.88 17.89 308 73955 80116 42466956
Acute kidney injury 74.00 17.89 359 73904 366978 42180094
Aspartate aminotransferase increased 72.71 17.89 22 74241 77141 42469931
Full blood count increased 71.36 17.89 35 74228 977 42546095
Bone lesion 68.17 17.89 53 74210 3413 42543659
Suicidal ideation 67.78 17.89 4 74259 48157 42498915
Inappropriate schedule of product administration 67.21 17.89 42 74221 95860 42451212
Agitation 66.96 17.89 15 74248 64299 42482773
Hypoglycaemia 66.40 17.89 12 74251 59842 42487230
Alanine aminotransferase increased 65.80 17.89 36 74227 88370 42458702
Hyperkalaemia 65.58 17.89 29 74234 80429 42466643
Blood creatine phosphokinase increased 65.15 17.89 5 74258 48333 42498739
Ascites 63.67 17.89 11 74252 56667 42490405
Red blood cell count decreased 62.21 17.89 160 74103 32555 42514517
Fluid retention 61.53 17.89 156 74107 31463 42515609
Suicide attempt 61.48 17.89 5 74258 46095 42500977
Product distribution issue 61.22 17.89 40 74223 1954 42545118
Cataract 60.61 17.89 152 74111 30452 42516620
Psoriasis 60.28 17.89 7 74256 48597 42498475
Incorrect dose administered 60.12 17.89 10 74253 52964 42494108
Sinusitis 58.95 17.89 199 74064 47093 42499979
Dizziness 58.69 17.89 678 73585 248576 42298496
Rheumatoid arthritis 58.31 17.89 4 74259 42436 42504636
Full blood count abnormal 57.72 17.89 147 74116 29729 42517343
Coma 56.74 17.89 12 74251 53542 42493530
Pulmonary thrombosis 56.13 17.89 71 74192 8277 42538795
Dyspnoea 55.89 17.89 1081 73182 441540 42105532
Wrong technique in product usage process 55.83 17.89 5 74258 42630 42504442
Stress 55.75 17.89 6 74257 44206 42502866
Back disorder 55.50 17.89 67 74196 7447 42539625
Pneumonia respiratory syncytial viral 54.67 17.89 33 74230 1401 42545671
Drug hypersensitivity 54.05 17.89 56 74207 99333 42447739
Thrombocytopenia 53.31 17.89 536 73727 189743 42357329
IVth nerve paralysis 52.60 17.89 24 74239 567 42546505
Hypoaesthesia 50.28 17.89 252 74011 71211 42475861
Cellulitis enterococcal 50.20 17.89 15 74248 98 42546974
COVID-19 pneumonia 49.97 17.89 114 74149 21499 42525573
Anxiety 48.00 17.89 83 74180 118477 42428595
White blood cell count abnormal 46.71 17.89 44 74219 3681 42543391
Aggression 46.57 17.89 10 74253 44153 42502919
Progressive multifocal leukoencephalopathy 46.54 17.89 77 74186 11459 42535613
Interstitial lung disease 46.40 17.89 41 74222 78421 42468651
Electrocardiogram QT prolonged 46.39 17.89 13 74250 47932 42499140
Hypercalcaemia 45.98 17.89 99 74164 17959 42529113
Arthropathy 45.57 17.89 134 74129 29463 42517609
Hip fracture 45.32 17.89 83 74180 13389 42533683
Haematuria 45.28 17.89 22 74241 57777 42489295
Pancreatitis 45.22 17.89 10 74253 43258 42503814
Respiratory syncytial virus infection 45.22 17.89 59 74204 7093 42539979
International normalised ratio increased 44.89 17.89 14 74249 48154 42498918
Hypotension 44.45 17.89 265 73998 257366 42289706
Lactic acidosis 44.30 17.89 12 74251 45249 42501823
Drug-induced liver injury 43.93 17.89 7 74256 38266 42508806
Seizure 43.03 17.89 91 74172 120470 42426602
Blood test abnormal 42.77 17.89 79 74184 12827 42534245
Melaena 42.47 17.89 8 74255 38738 42508334
Bradycardia 42.29 17.89 52 74211 85432 42461640
Drug reaction with eosinophilia and systemic symptoms 41.47 17.89 11 74252 42064 42505008
Oxygen saturation decreased 40.46 17.89 32 74231 64655 42482417
Hypokalaemia 39.45 17.89 40 74223 71681 42475391
Psychotic disorder 39.41 17.89 3 74260 29205 42517867
Monoclonal immunoglobulin increased 39.27 17.89 18 74245 430 42546642
Sedation 38.77 17.89 4 74259 30471 42516601
Balance disorder 38.58 17.89 175 74088 47470 42499602
Angioedema 38.43 17.89 13 74250 42464 42504608
Dysarthria 38.13 17.89 11 74252 39796 42507276
Rib fracture 37.86 17.89 87 74176 16484 42530588
Diarrhoea 37.79 17.89 1060 73203 459789 42087283
Loss of personal independence in daily activities 37.47 17.89 20 74243 49796 42497276
Anaphylactic reaction 37.10 17.89 14 74249 42729 42504343
Respiratory tract infection 36.61 17.89 115 74148 26207 42520865
Pancytopenia 36.53 17.89 339 73924 117404 42429668
Medication error 36.01 17.89 7 74256 33147 42513925
Drug ineffective for unapproved indication 35.51 17.89 18 74245 46145 42500927
Therapeutic product effect incomplete 35.24 17.89 43 74220 70896 42476176
Fall 34.83 17.89 588 73675 233932 42313140
Blood bilirubin increased 34.78 17.89 15 74248 42237 42504835
Cardiac arrest 34.60 17.89 88 74175 109232 42437840
Parainfluenzae virus infection 34.58 17.89 37 74226 3606 42543466
Epilepsy 34.45 17.89 3 74260 26168 42520904
Coronary artery disease 34.33 17.89 26 74237 53694 42493378
Upper respiratory tract infection 34.22 17.89 155 74108 42018 42505054
Asthma 33.99 17.89 35 74228 62279 42484793
Cardiogenic shock 33.86 17.89 10 74253 35630 42511442
Cholestasis 33.56 17.89 8 74255 32871 42514201
Gastric disorder 33.43 17.89 68 74195 11854 42535218
Protein total increased 33.38 17.89 31 74232 2547 42544525
Metabolic acidosis 33.26 17.89 25 74238 51833 42495239
Tooth infection 33.03 17.89 54 74209 7957 42539115
Gamma-glutamyltransferase increased 32.98 17.89 8 74255 32489 42514583
Feeling abnormal 32.70 17.89 221 74042 69565 42477507
Squamous cell carcinoma of skin 32.66 17.89 70 74193 12656 42534416
Upper limb fracture 32.31 17.89 44 74219 5512 42541560
Keratopathy 31.72 17.89 18 74245 680 42546392
Pyrexia 31.60 17.89 904 73359 393138 42153934
Blood urea increased 31.52 17.89 9 74254 32784 42514288
Gastrointestinal haemorrhage 31.44 17.89 78 74185 97648 42449424
Tremor 31.04 17.89 281 73982 96648 42450424
Body height decreased 31.00 17.89 37 74226 4063 42543009
Pathological fracture 30.90 17.89 42 74221 5251 42541821
Tachycardia 30.74 17.89 83 74180 101004 42446068
White blood cell disorder 30.65 17.89 26 74237 1895 42545177
SARS-CoV-2 test positive 30.49 17.89 53 74210 8207 42538865
Blood pressure systolic increased 30.18 17.89 6 74257 27962 42519110
Anaphylactic shock 30.14 17.89 3 74260 23514 42523558
Eczema 29.86 17.89 11 74252 34075 42512997
Headache 29.81 17.89 270 73993 239099 42307973
JC virus infection 29.38 17.89 31 74232 2973 42544099
Blood creatinine increased 29.35 17.89 96 74167 109907 42437165
Haematochezia 28.42 17.89 36 74227 58400 42488672
Neutropenic sepsis 28.28 17.89 76 74187 15870 42531202
Rhinovirus infection 28.17 17.89 45 74218 6503 42540569
Paraproteinaemia 28.08 17.89 14 74249 405 42546667
Generalised tonic-clonic seizure 27.76 17.89 6 74257 26373 42520699
Musculoskeletal disorder 27.71 17.89 45 74218 6593 42540479
Ventricular tachycardia 27.68 17.89 9 74254 30151 42516921
Jaundice 27.34 17.89 13 74250 34576 42512496
Blood lactate dehydrogenase increased 27.31 17.89 6 74257 26075 42520997
Malaise 27.26 17.89 520 73743 211636 42335436
Blood immunoglobulin M increased 27.00 17.89 12 74251 266 42546806
Hepatic function abnormal 26.97 17.89 30 74233 51537 42495535
Hyperlipidaemia 26.92 17.89 3 74260 21513 42525559
Lower limb fracture 26.88 17.89 38 74225 4929 42542143
Agranulocytosis 26.61 17.89 10 74253 30602 42516470
Eosinophilia 26.57 17.89 12 74251 32887 42514185
Osteolysis 26.57 17.89 32 74231 3548 42543524
Shock 26.19 17.89 9 74254 29112 42517960
C-reactive protein increased 26.16 17.89 44 74219 63516 42483556
Treatment failure 26.10 17.89 43 74220 62581 42484491
Haematemesis 26.03 17.89 10 74253 30189 42516883
Coronavirus infection 25.47 17.89 38 74225 5176 42541896
Therapy interrupted 25.43 17.89 91 74172 22159 42524913
Rash pruritic 25.41 17.89 121 74142 33482 42513590
Leukocytosis 25.33 17.89 10 74253 29698 42517374
Arthralgia 25.33 17.89 232 74031 205006 42342066
Transaminases increased 25.03 17.89 13 74250 32872 42514200
Lymphodepletion 25.00 17.89 7 74256 35 42547037
Injection site erythema 24.81 17.89 3 74260 20192 42526880
Blood immunoglobulin A increased 24.79 17.89 13 74250 419 42546653
General physical health deterioration 24.78 17.89 158 74105 151088 42395984
Rectal haemorrhage 24.71 17.89 30 74233 49576 42497496
Lower respiratory tract infection 24.66 17.89 139 74124 41067 42506005
Blood alkaline phosphatase increased 24.52 17.89 14 74249 33583 42513489
Dyskinesia 24.34 17.89 7 74256 25383 42521689
Ventricular fibrillation 24.31 17.89 11 74252 30112 42516960
Mucosal inflammation 23.41 17.89 31 74232 49343 42497729
Pneumocystis jirovecii pneumonia 23.06 17.89 96 74167 25085 42521987
Spinal fracture 22.95 17.89 50 74213 9140 42537932
Toxic epidermal necrolysis 22.82 17.89 9 74254 26741 42520331
Protein total abnormal 22.71 17.89 12 74251 393 42546679
Pneumonia influenzal 22.70 17.89 22 74241 1907 42545165
Proteinuria 22.66 17.89 6 74257 22977 42524095
Cerebrovascular accident 22.66 17.89 264 73999 96896 42450176
Hypothyroidism 22.53 17.89 14 74249 32070 42515002
Pleural effusion 22.48 17.89 90 74173 97076 42449996
Multiple allergies 22.40 17.89 30 74233 3698 42543374
Arteriosclerosis coronary artery 22.40 17.89 3 74260 18674 42528398
IgA nephropathy 22.34 17.89 24 74239 2350 42544722
Listeriosis 22.31 17.89 19 74244 1392 42545680
Vertebral lesion 22.20 17.89 10 74253 229 42546843
Haemoglobin decreased 22.20 17.89 339 73924 132132 42414940
Swelling face 22.14 17.89 101 74162 27453 42519619
Hypomagnesaemia 22.07 17.89 11 74252 28477 42518595
Clostridium difficile infection 22.03 17.89 88 74175 22571 42524501
Respiration abnormal 21.99 17.89 31 74232 4011 42543061
Respiratory arrest 21.99 17.89 11 74252 28413 42518659
Amnesia 21.94 17.89 103 74160 28334 42518738
Product prescribing error 21.92 17.89 9 74254 26103 42520969
Circulatory collapse 21.79 17.89 7 74256 23629 42523443
Spinal disorder 21.77 17.89 33 74230 4558 42542514
Benign prostatic hyperplasia 21.72 17.89 5 74258 21047 42526025
Altered state of consciousness 21.63 17.89 12 74251 29247 42517825
Stevens-Johnson syndrome 21.47 17.89 6 74257 22172 42524900
H1N1 influenza 21.17 17.89 17 74246 1147 42545925
Cerebral toxoplasmosis 21.14 17.89 22 74241 2076 42544996
Product quality issue 21.14 17.89 3 74260 17879 42529193
Sleep disorder 21.01 17.89 32 74231 48063 42499009
Abnormal behaviour 20.82 17.89 10 74253 26441 42520631
Viral infection 20.81 17.89 86 74177 22397 42524675
Surgery 20.72 17.89 3 74260 17613 42529459
White blood cell count increased 20.68 17.89 29 74234 45058 42502014
Hepatic enzyme increased 20.45 17.89 30 74233 45754 42501318
Sinus disorder 20.34 17.89 44 74219 8006 42539066
Drug ineffective 20.33 17.89 895 73368 629302 41917770
Unresponsive to stimuli 20.32 17.89 15 74248 31388 42515684
Musculoskeletal stiffness 20.26 17.89 44 74219 57721 42489351
Lymphadenopathy 20.24 17.89 17 74246 33348 42513724
Urinary tract infection 20.22 17.89 263 74000 99021 42448051
Restlessness 20.21 17.89 13 74250 29236 42517836
Diabetic ketoacidosis 19.96 17.89 7 74256 22360 42524712
Hypoacusis 19.29 17.89 74 74189 18628 42528444
Ageusia 19.27 17.89 54 74209 11551 42535521
Blood pressure abnormal 19.10 17.89 49 74214 9949 42537123
Mobility decreased 19.06 17.89 20 74243 35286 42511786
Wheezing 18.99 17.89 42 74221 54739 42492333
Haemoptysis 18.96 17.89 32 74231 46135 42500937
Depression 18.92 17.89 115 74148 111248 42435824
Neoplasm 18.92 17.89 37 74226 6268 42540804
Bone disorder 18.87 17.89 38 74225 6575 42540497
Nightmare 18.87 17.89 10 74253 25002 42522070
Myocardial ischaemia 18.77 17.89 4 74259 17758 42529314
Metastases to liver 18.70 17.89 3 74260 16323 42530749
Gallbladder disorder 18.55 17.89 40 74223 7262 42539810
Encephalopathy 18.54 17.89 27 74236 41306 42505766
Seasonal allergy 18.08 17.89 42 74221 8013 42539059
Osteoarthritis 18.06 17.89 10 74253 24395 42522677
Cardio-respiratory arrest 17.93 17.89 48 74215 58588 42488484

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Death 5083.52 18.94 4526 95736 694343 109794694
Pneumonia 2795.22 18.94 3679 96583 873035 109616002
Neutropenia 2437.18 18.94 2289 97973 372331 110116706
White blood cell count decreased 2095.08 18.94 1702 98560 227688 110261349
Full blood count decreased 1666.73 18.94 734 99528 31365 110457672
Neuropathy peripheral 1289.22 18.94 1161 99101 178116 110310921
Fatigue 907.11 18.94 2779 97483 1213179 109275858
Neutrophil count decreased 830.94 18.94 764 99498 120177 110368860
Platelet count decreased 734.18 18.94 972 99290 229471 110259566
Plasma cell myeloma recurrent 677.25 18.94 251 100011 6791 110482246
Thrombosis 598.35 18.94 608 99654 108054 110380983
Plasma cell myeloma 551.69 18.94 457 99805 62479 110426558
Laboratory test abnormal 543.64 18.94 392 99870 43687 110445350
COVID-19 489.26 18.94 831 99431 244229 110244808
Hospitalisation 474.99 18.94 615 99647 141878 110347159
Plasmacytoma 460.32 18.94 175 100087 5087 110483950
Constipation 416.80 18.94 968 99294 356818 110132219
Influenza 413.38 18.94 629 99633 168472 110320565
Thrombocytopenia 351.80 18.94 893 99369 347992 110141045
Sepsis 349.10 18.94 856 99406 326490 110162547
Unevaluable event 345.31 18.94 342 99920 58885 110430152
Cytopenia 335.60 18.94 252 100010 29864 110459173
Drug interaction 334.88 18.94 33 100229 500150 109988887
Rash 306.89 18.94 1512 98750 819452 109669585
Anaemia 300.96 18.94 1133 99129 545953 109943084
Deep vein thrombosis 289.00 18.94 482 99780 139405 110349632
Plasma cell myeloma refractory 286.86 18.94 96 100166 1905 110487132
Condition aggravated 277.84 18.94 161 100101 734675 109754362
Human chorionic gonadotropin increased 257.92 18.94 83 100179 1449 110487588
Atrial fibrillation 247.23 18.94 603 99659 229039 110259998
Rheumatoid arthritis 243.11 18.94 6 100256 299607 110189430
Drug hypersensitivity 214.72 18.94 72 100190 454018 110035019
Light chain analysis increased 208.43 18.94 79 100183 2276 110486761
Emergency care examination 199.37 18.94 46 100216 200 110488837
Product dose omission issue 193.07 18.94 686 99576 321096 110167941
Plasma cell leukaemia 191.89 18.94 72 100190 2016 110487021
Adverse event 168.61 18.94 331 99931 108478 110380559
Muscle spasms 165.95 18.94 592 99670 277565 110211472
Product use in unapproved indication 163.26 18.94 102 100160 447275 110041762
Bronchitis 160.08 18.94 404 99858 156628 110332409
Pericarditis 158.94 18.94 10 100252 219104 110269933
Glossodynia 155.61 18.94 12 100250 221992 110267045
Urinary tract infection 155 18.94 646 99616 325636 110163401
Cardiac disorder 153.66 18.94 260 100002 76020 110413017
Off label use 149.03 18.94 2039 98223 1498146 108990891
Overdose 147.32 18.94 19 100243 233775 110255262
Asthenia 143.71 18.94 1092 99170 687907 109801130
COVID-19 pneumonia 142.26 18.94 172 100090 36971 110452066
Fibromyalgia 140.23 18.94 3 100259 170906 110318131
Product distribution issue 138.26 18.94 71 100191 4275 110484762
Infection 136.03 18.94 669 99593 361531 110127506
Abdominal pain 135.90 18.94 159 100103 512830 109976207
Therapeutic product effect decreased 135.78 18.94 28 100234 244288 110244749
Musculoskeletal stiffness 134.59 18.94 43 100219 279779 110209258
Diarrhoea 132.86 18.94 1596 98666 1137909 109351128
Bone pain 131.17 18.94 222 100040 64911 110424126
Arthralgia 130.05 18.94 325 99937 779307 109709730
Folliculitis 130.03 18.94 5 100257 167648 110321389
Type 2 diabetes mellitus 128.80 18.94 8 100254 177224 110311813
Renal disorder 127.79 18.94 189 100073 49290 110439747
Injection site pain 126.45 18.94 9 100253 177913 110311124
Wound 125.95 18.94 29 100233 234408 110254629
Hypercalcaemia 124.52 18.94 181 100081 46476 110442561
Hepatic enzyme increased 124.33 18.94 68 100194 320824 110168213
Peripheral swelling 123.47 18.94 705 99557 403329 110085708
Pancytopenia 123.14 18.94 444 99818 209169 110279868
Red blood cell count decreased 121.41 18.94 216 100046 65707 110423330
Mobility decreased 120.53 18.94 33 100229 237389 110251648
Respiratory syncytial virus infection 120.27 18.94 102 100160 14382 110474655
Impaired healing 119.20 18.94 18 100244 196699 110292338
Wheezing 114.53 18.94 44 100218 255186 110233851
Pulmonary thrombosis 113.83 18.94 97 100165 13766 110475271
Tremor 111.76 18.94 420 99842 201812 110287225
Blood cholesterol increased 111.75 18.94 17 100245 184768 110304269
Discomfort 110.58 18.94 29 100233 214678 110274359
Therapy interrupted 109.99 18.94 177 100085 49645 110439392
Treatment failure 109.96 18.94 57 100205 277177 110211860
Muscle injury 109.88 18.94 4 100258 140803 110348234
Febrile neutropenia 109.01 18.94 571 99691 316196 110172841
Osteoarthritis 107.74 18.94 18 100244 182605 110306432
Haemoglobin decreased 106.94 18.94 478 99784 248249 110240788
Irritable bowel syndrome 106.76 18.94 12 100250 164203 110324834
Liver injury 105.76 18.94 8 100254 150405 110338632
Inflammation 99.70 18.94 26 100236 193212 110295825
Progressive multifocal leukoencephalopathy 99.56 18.94 118 100144 24838 110464199
Injury 99.13 18.94 20 100242 177245 110311792
Renal failure 98.57 18.94 437 99825 226137 110262900
Headache 98.20 18.94 439 99823 881938 109607099
Ill-defined disorder 98.19 18.94 13 100249 156840 110332197
Infusion related reaction 97.84 18.94 121 100141 381041 110107996
Psoriasis 96.88 18.94 8 100254 139985 110349052
Hip fracture 96.18 18.94 138 100124 35013 110454024
Fall 94.70 18.94 898 99364 602584 109886453
Vomiting 93.75 18.94 466 99796 910209 109578828
Back pain 92.27 18.94 614 99648 370382 110118655
Bursitis 91.09 18.94 7 100255 129911 110359126
Cerebrovascular accident 90.78 18.94 365 99897 180919 110308118
Respiratory tract infection 90.02 18.94 200 100062 71417 110417620
Osteolysis 89.10 18.94 58 100204 5465 110483572
Neutropenic sepsis 89.00 18.94 124 100138 30622 110458415
Anxiety 78.05 18.94 120 100142 344958 110144079
Drug-induced liver injury 77.47 18.94 9 100253 120058 110368979
Pyrexia 76.82 18.94 1191 99071 897074 109591963
Intentional product misuse 76.41 18.94 14 100248 132890 110356147
Adverse drug reaction 75.54 18.94 239 100023 105320 110383717
Lip dry 74.29 18.94 4 100258 100079 110388958
Paraproteinaemia 73.78 18.94 25 100237 516 110488521
Blister 73.44 18.94 59 100203 227317 110261720
Stress 72.95 18.94 6 100256 105342 110383695
Dizziness 72.93 18.94 959 99303 697234 109791803
Pulmonary embolism 71.93 18.94 384 99878 214090 110274947
Suicide attempt 71.29 18.94 6 100256 103388 110385649
Leukopenia 70.85 18.94 295 99967 148496 110340541
Sleep disorder 70.05 18.94 47 100215 198597 110290440
Abdominal discomfort 69.64 18.94 159 100103 393699 110095338
Injection site erythema 69.17 18.94 4 100258 94172 110394865
Rhabdomyolysis 68.54 18.94 13 100249 120388 110368649
Tooth disorder 68.11 18.94 107 100155 29402 110459635
Pneumonia respiratory syncytial viral 68.03 18.94 38 100224 2711 110486326
Musculoskeletal pain 66.30 18.94 42 100220 182981 110306056
Epilepsy 65.94 18.94 7 100255 100202 110388835
Migraine 65.54 18.94 37 100225 171615 110317422
Bone lesion 65.27 18.94 53 100209 7034 110482003
IVth nerve paralysis 65.24 18.94 24 100238 635 110488402
Asthma 64.67 18.94 79 100183 250212 110238825
Pathological fracture 63.73 18.94 66 100196 11966 110477071
Peripheral venous disease 63.58 18.94 3 100259 84114 110404923
Illness 63.39 18.94 191 100071 81980 110407057
Wrong technique in product usage process 63.28 18.94 4 100258 87344 110401693
Squamous cell carcinoma of skin 63.17 18.94 78 100184 17125 110471912
Medication error 63.00 18.94 10 100252 105356 110383681
Weight increased 62.99 18.94 184 100078 419460 110069577
Hypertension 62.68 18.94 244 100018 509840 109979197
Hyponatraemia 61.35 18.94 64 100198 217589 110271448
Dyspnoea 61.31 18.94 1372 98890 1105500 109383537
Coma 60.52 18.94 16 100246 117853 110371184
White blood cell count abnormal 60.14 18.94 50 100212 6859 110482178
Nasopharyngitis 59.36 18.94 582 99680 393779 110095258
Prescribed overdose 57.93 18.94 6 100256 87575 110401462
Product quality issue 57.65 18.94 3 100259 77296 110411741
Arthropathy 57.63 18.94 108 100154 287414 110201623
Grip strength decreased 57.11 18.94 4 100258 80170 110408867
Product use issue 56.57 18.94 124 100138 311571 110177466
Pulmonary fibrosis 56.04 18.94 12 100250 102030 110387007
Hypogammaglobulinaemia 55.19 18.94 79 100183 19997 110469040
Pain 55.06 18.94 577 99685 954378 109534659
Agitation 54.99 18.94 17 100245 113034 110376003
Colitis ulcerative 54.70 18.94 4 100258 77359 110411678
Therapeutic product effect incomplete 54.35 18.94 74 100188 223731 110265306
Depression 53.76 18.94 131 100131 317204 110171833
Blood calcium increased 52.57 18.94 73 100189 17967 110471070
Loss of personal independence in daily activities 52.21 18.94 36 100226 149984 110339053
Monoclonal immunoglobulin present 51.90 18.94 31 100231 2509 110486528
Anaphylactic reaction 50.76 18.94 20 100242 114280 110374757
Pneumonia pneumococcal 49.72 18.94 39 100223 4926 110484111
Incorrect dose administered 49.67 18.94 16 100246 103625 110385412
Rib fracture 49.00 18.94 100 100162 33670 110455367
Lactic acidosis 48.80 18.94 12 100250 92799 110396238
Rash pruritic 48.70 18.94 197 100065 97872 110391165
Aspartate aminotransferase increased 48.58 18.94 44 100218 159892 110329145
Blood creatine phosphokinase increased 48.35 18.94 5 100257 73072 110415965
Pneumocystis jirovecii pneumonia 47.80 18.94 114 100148 42621 110446416
Upper respiratory tract infection 47.37 18.94 240 100022 131088 110357949
Inappropriate schedule of product administration 46.80 18.94 70 100192 203567 110285470
Osteoporosis 46.35 18.94 11 100251 87141 110401896
Stomatitis 46.21 18.94 111 100151 270131 110218906
Immune system disorder 46.05 18.94 59 100203 13442 110475595
Underdose 45.77 18.94 3 100259 63551 110425486
Parainfluenzae virus infection 45.76 18.94 43 100219 6931 110482106
Cataract 45.47 18.94 167 100095 79318 110409719
Keratopathy 45.33 18.94 23 100239 1350 110487687
Pneumonia influenzal 44.98 18.94 33 100229 3772 110485265
Coronavirus infection 44.62 18.94 49 100213 9496 110479541
Neutrophil count abnormal 44.38 18.94 37 100225 5095 110483942
Peripheral sensory neuropathy 43.47 18.94 64 100198 16616 110472421
Pneumonia parainfluenzae viral 43.33 18.94 18 100244 663 110488374
Sedation 43.07 18.94 6 100256 69677 110419360
Hepatitis 42.98 18.94 14 100248 90040 110398997
Angioedema 42.50 18.94 18 100244 98482 110390555
Full blood count increased 41.65 18.94 18 100244 732 110488305
Hypoglycaemia 41.56 18.94 27 100235 116077 110372960
Crystal nephropathy 41.47 18.94 24 100238 1832 110487205
Hypersensitivity 41.27 18.94 207 100055 403791 110085246
Blood pressure systolic increased 41.23 18.94 12 100250 82979 110406058
Full blood count abnormal 41.09 18.94 128 100134 55924 110433113
Suicidal ideation 40.80 18.94 17 100245 93920 110395117
Urticaria 40.11 18.94 151 100111 318706 110170331
Pallor 39.69 18.94 3 100259 56464 110432573
Weight decreased 39.62 18.94 255 100007 467802 110021235
Lymphocyte count decreased 39.48 18.94 128 100134 57115 110431922
Hip arthroplasty 39.14 18.94 3 100259 55810 110433227
C-reactive protein increased 38.46 18.94 88 100174 217831 110271206
Blepharospasm 38.32 18.94 3 100259 54848 110434189
Cellulitis enterococcal 38.14 18.94 9 100253 44 110488993
Sciatica 38.11 18.94 18 100244 92381 110396656
Respiratory tract infection viral 38.11 18.94 36 100226 5842 110483195
Myelosuppression 38.03 18.94 178 100084 94162 110394875
Localised infection 37.97 18.94 105 100157 42943 110446094
Alanine aminotransferase increased 37.72 18.94 68 100194 183705 110305332
JC virus infection 37.39 18.94 34 100228 5256 110483781
Hospice care 37.14 18.94 51 100211 12422 110476615
Drug ineffective for unapproved indication 36.69 18.94 24 100238 102814 110386223
Toxicity to various agents 36.63 18.94 270 99992 480285 110008752
Tumour lysis syndrome 36.45 18.94 84 100178 30717 110458320
Alopecia 36.06 18.94 189 100073 364564 110124473
Oxygen saturation decreased 36.03 18.94 54 100208 156928 110332109
Pancreatitis 35.93 18.94 20 100242 93513 110395524
Bone marrow disorder 35.59 18.94 30 100232 4193 110484844
Abdominal pain upper 35.58 18.94 179 100083 348932 110140105
Drug reaction with eosinophilia and systemic symptoms 35.42 18.94 15 100247 82080 110406957
Dehydration 35.19 18.94 398 99864 279113 110209924
Rectal haemorrhage 35.17 18.94 34 100228 119799 110369238
Monoclonal immunoglobulin increased 34.80 18.94 15 100247 606 110488431
Electrocardiogram QT prolonged 34.27 18.94 29 100233 108931 110380106
Frequent bowel movements 34.24 18.94 11 100251 71379 110417658
Spinal cord compression 33.98 18.94 38 100224 7514 110481523
Liver disorder 33.55 18.94 48 100214 142195 110346842
Joint stiffness 32.90 18.94 10 100252 67233 110421804
Injection site bruising 32.67 18.94 4 100258 51259 110437778
Listeriosis 32.35 18.94 24 100238 2790 110486247
Rhinovirus infection 31.83 18.94 46 100216 11743 110477294
Viral infection 31.53 18.94 113 100149 53026 110436011
Sleep disorder due to a general medical condition 31.03 18.94 5 100257 52107 110436930
Drug ineffective 30.88 18.94 1099 99163 1519441 108969596
Product dispensing issue 30.86 18.94 14 100248 640 110488397
Blood pressure increased 30.80 18.94 125 100137 258248 110230789
Blood test abnormal 30.68 18.94 75 100187 28479 110460558
SARS-CoV-2 test positive 30.54 18.94 55 100207 16880 110472157
Diverticulitis 30.23 18.94 112 100150 53410 110435627
Ascites 30.05 18.94 24 100238 92784 110396253
IgA nephropathy 29.79 18.94 24 100238 3149 110485888
Drug level increased 29.75 18.94 4 100258 47715 110441322
Atrial flutter 29.63 18.94 67 100195 24195 110464842
Gastrointestinal disorder 29.51 18.94 116 100146 241836 110247201
Nail disorder 29.48 18.94 8 100254 57927 110431110
Gastrooesophageal reflux disease 29.14 18.94 76 100186 179900 110309137
Injection site swelling 28.80 18.94 10 100252 61780 110427257
Blood pressure fluctuation 28.74 18.94 16 100246 74808 110414229
Road traffic accident 28.68 18.94 33 100229 107365 110381672
Bacterial sepsis 28.62 18.94 41 100221 10385 110478652
Haematemesis 28.54 18.94 9 100253 59099 110429938
Onychomadesis 28.06 18.94 4 100258 45659 110443378
Cardiac failure congestive 27.85 18.94 233 100029 150767 110338270
Lymphodepletion 27.54 18.94 7 100255 49 110488988
Melaena 27.44 18.94 14 100248 68743 110420294
International normalised ratio increased 27.40 18.94 23 100239 86749 110402288
Hyperkalaemia 27.20 18.94 51 100211 135745 110353292
Spinal fracture 27.09 18.94 62 100200 22571 110466466
Light chain analysis decreased 27.04 18.94 6 100256 21 110489016
Chest discomfort 26.95 18.94 75 100187 173773 110315264
Back disorder 26.93 18.94 59 100203 20863 110468174
Toxic epidermal necrolysis 26.75 18.94 9 100253 56718 110432319
Feeling hot 26.56 18.94 26 100236 91080 110397957
Disease progression 26.55 18.94 338 99924 243696 110245341
Joint swelling 26.49 18.94 265 99997 442580 110046457
Dyskinesia 26.37 18.94 7 100255 51439 110437598
Metabolic acidosis 26.26 18.94 31 100231 99713 110389324
Hypothyroidism 26.02 18.94 17 100245 72882 110416155
Foot deformity 26.01 18.94 6 100256 48474 110440563
Vision blurred 25.92 18.94 203 100059 128819 110360218
Bacteraemia 25.89 18.94 91 100171 42299 110446738
Plasma cells increased 25.86 18.94 8 100254 122 110488915
Cellulitis 25.72 18.94 199 100063 125817 110363220
General physical health deterioration 25.64 18.94 254 100008 425041 110063996
Eczema 25.61 18.94 17 100245 72276 110416761
Hallucination, visual 25.47 18.94 3 100259 39602 110449435
Septic shock 25.40 18.94 236 100026 157292 110331745
Haematochezia 25.30 18.94 41 100221 115483 110373554
Accidental exposure to product 25.27 18.94 7 100255 50001 110439036
Generalised tonic-clonic seizure 25.23 18.94 9 100253 54671 110434366
Natural killer cell count decreased 25.11 18.94 8 100254 135 110488902
Femur fracture 25.06 18.94 93 100169 44376 110444661
Accidental overdose 24.84 18.94 8 100254 51826 110437211
Humerus fracture 24.76 18.94 39 100223 10737 110478300
Compression fracture 24.69 18.94 36 100226 9263 110479774
Blood disorder 24.64 18.94 37 100225 9773 110479264
Myelodysplastic syndrome 24.22 18.94 82 100180 37402 110451635
Blood bilirubin increased 24.16 18.94 20 100242 75952 110413085
Musculoskeletal chest pain 24.10 18.94 69 100193 28778 110460259
Clavicle fracture 24.07 18.94 27 100235 5357 110483680
Arthritis 24.02 18.94 75 100187 167511 110321526
Hypokalaemia 23.85 18.94 85 100177 182363 110306674
Hepatic cirrhosis 23.83 18.94 16 100246 67610 110421427
Dry mouth 23.66 18.94 97 100165 199851 110289186
Cardiac failure 23.52 18.94 267 99995 187359 110301678
Depressed mood 23.36 18.94 13 100249 60796 110428241
Clostridium difficile infection 22.98 18.94 101 100161 52028 110437009
Leukocytosis 22.96 18.94 10 100252 53818 110435219
Anaphylactic shock 22.92 18.94 9 100253 51537 110437500
Eosinophilia 22.82 18.94 12 100250 57924 110431113
Gait inability 22.53 18.94 57 100205 136319 110352718
Hemiparesis 22.46 18.94 6 100256 43897 110445140
Swelling face 22.41 18.94 152 100110 92169 110396868
Fracture 22.39 18.94 61 100201 24727 110464310
Dyspepsia 22.37 18.94 93 100169 190872 110298165
Surgery 22.37 18.94 5 100257 41278 110447759
Hyperlipidaemia 22.36 18.94 3 100259 35845 110453192
Wound infection 22.31 18.94 33 100229 96432 110392605
Dysarthria 22.30 18.94 26 100236 84095 110404942
Bile acid malabsorption 21.90 18.94 10 100252 464 110488573
Peritonitis viral 21.89 18.94 6 100256 58 110488979
Pulmonary oedema 21.68 18.94 161 100101 100498 110388539
Restlessness 21.65 18.94 12 100250 56247 110432790
Upper limb fracture 21.53 18.94 54 100208 20834 110468203
Swelling 21.43 18.94 209 100053 350832 110138205
Hypotension 21.39 18.94 340 99922 523509 109965528
Neutrophil count increased 21.37 18.94 3 100259 34649 110454388
Therapy change 21.36 18.94 35 100227 9962 110479075
Bradycardia 21.31 18.94 71 100191 155446 110333591
Light chain analysis abnormal 21.19 18.94 8 100254 228 110488809
Seizure 21.07 18.94 116 100146 221069 110267968
Gastrointestinal infection 20.95 18.94 42 100220 13963 110475074
Lung disorder 20.89 18.94 88 100174 179959 110309078
Device related sepsis 20.88 18.94 30 100232 7617 110481420
Aggression 20.87 18.94 14 100248 59196 110429841
Middle ear inflammation 20.64 18.94 8 100254 245 110488792
Obstructive airways disorder 20.61 18.94 8 100254 46141 110442896
Therapy partial responder 20.46 18.94 77 100185 36984 110452053
Tooth infection 20.40 18.94 55 100207 22161 110466876
Vasculitis 20.14 18.94 4 100258 35869 110453168
Skin ulcer 19.94 18.94 17 100245 63628 110425409
Metapneumovirus infection 19.86 18.94 17 100245 2427 110486610
Masked fever 19.79 18.94 5 100257 34 110489003
Ear swelling 19.73 18.94 16 100246 2120 110486917
Jugular vein occlusion 19.67 18.94 6 100256 87 110488950
Cholestasis 19.29 18.94 18 100244 64500 110424537
Night sweats 19.17 18.94 60 100202 133923 110355114
Device issue 19.08 18.94 4 100258 34531 110454506

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L04AX06 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
IMMUNOSUPPRESSANTS
IMMUNOSUPPRESSANTS
Other immunosuppressants
MeSH PA D000970 Antineoplastic Agents
MeSH PA D006131 Growth Inhibitors
MeSH PA D006133 Growth Substances
MeSH PA D007155 Immunologic Factors
MeSH PA D020533 Angiogenesis Inhibitors
FDA EPC N0000184014 Thalidomide Analog
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:48422 angiogenesis inhibitor
CHEBI has role CHEBI:50846 immunomodulator
CHEBI has role CHEBI:75835 anti-anaemic agent
CHEBI has role CHEBI:233423 antifibrotic agent

Related Drugs by ATC class:

L04AX Other immunosuppressants 8 drugs
azathioprinedimethyl fumaratediroximel fumaratelenalidomidemethotrexatepirfenidonetegomil fumaratethalidomide

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Multiple myeloma indication 109989006 DOID:9538




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.84 acidic
pKa2 1.86 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
1MG POMALIDOMIDE BRECKENRIDGE A210111 Oct. 30, 2020 RX CAPSULE ORAL Aug. 29, 2026 PATENT CHALLENGE
2MG POMALIDOMIDE BRECKENRIDGE A210111 Oct. 30, 2020 RX CAPSULE ORAL Aug. 29, 2026 PATENT CHALLENGE
3MG POMALIDOMIDE BRECKENRIDGE A210111 Oct. 30, 2020 RX CAPSULE ORAL Aug. 29, 2026 PATENT CHALLENGE
4MG POMALIDOMIDE BRECKENRIDGE A210111 Oct. 30, 2020 RX CAPSULE ORAL Aug. 29, 2026 PATENT CHALLENGE
1MG POMALYST BRISTOL N204026 Feb. 8, 2013 RX CAPSULE ORAL May 14, 2027 FOR THE TREATMENT OF KAPOSI SARCOMA (KS) IN ADULT PATIENTS WHO ARE HIV-NEGATIVE
1MG POMALYST BRISTOL N204026 Feb. 8, 2013 RX CAPSULE ORAL May 14, 2027 INDICATED FOR THE TREATMENT OF ADULT PATIENTS WITH AIDS-RELATED KAPOSI SARCOMA (KS) AFTER FAILURE OF HIGHLY ACTIVE ANTIRETROVIRAL THERAPY (HAART)
2MG POMALYST BRISTOL N204026 Feb. 8, 2013 RX CAPSULE ORAL May 14, 2027 FOR THE TREATMENT OF KAPOSI SARCOMA (KS) IN ADULT PATIENTS WHO ARE HIV-NEGATIVE
2MG POMALYST BRISTOL N204026 Feb. 8, 2013 RX CAPSULE ORAL May 14, 2027 INDICATED FOR THE TREATMENT OF ADULT PATIENTS WITH AIDS-RELATED KAPOSI SARCOMA (KS) AFTER FAILURE OF HIGHLY ACTIVE ANTIRETROVIRAL THERAPY (HAART)
3MG POMALYST BRISTOL N204026 Feb. 8, 2013 RX CAPSULE ORAL May 14, 2027 FOR THE TREATMENT OF KAPOSI SARCOMA (KS) IN ADULT PATIENTS WHO ARE HIV-NEGATIVE
3MG POMALYST BRISTOL N204026 Feb. 8, 2013 RX CAPSULE ORAL May 14, 2027 INDICATED FOR THE TREATMENT OF ADULT PATIENTS WITH AIDS-RELATED KAPOSI SARCOMA (KS) AFTER FAILURE OF HIGHLY ACTIVE ANTIRETROVIRAL THERAPY (HAART)
4MG POMALYST BRISTOL N204026 Feb. 8, 2013 RX CAPSULE ORAL May 14, 2027 FOR THE TREATMENT OF KAPOSI SARCOMA (KS) IN ADULT PATIENTS WHO ARE HIV-NEGATIVE
4MG POMALYST BRISTOL N204026 Feb. 8, 2013 RX CAPSULE ORAL May 14, 2027 INDICATED FOR THE TREATMENT OF ADULT PATIENTS WITH AIDS-RELATED KAPOSI SARCOMA (KS) AFTER FAILURE OF HIGHLY ACTIVE ANTIRETROVIRAL THERAPY (HAART)
1MG POMALYST BRISTOL N204026 Feb. 8, 2013 RX CAPSULE ORAL Nov. 14, 2027 PEDIATRIC EXCLUSIVITY
2MG POMALYST BRISTOL N204026 Feb. 8, 2013 RX CAPSULE ORAL Nov. 14, 2027 PEDIATRIC EXCLUSIVITY
3MG POMALYST BRISTOL N204026 Feb. 8, 2013 RX CAPSULE ORAL Nov. 14, 2027 PEDIATRIC EXCLUSIVITY
4MG POMALYST BRISTOL N204026 Feb. 8, 2013 RX CAPSULE ORAL Nov. 14, 2027 PEDIATRIC EXCLUSIVITY

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Protein cereblon Cytosolic other MODULATOR EC50 6.58 SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE
Tumor necrosis factor Cytokine IC50 7.48 CHEMBL
Interleukin-1 beta Cytokine IC50 7.33 CHEMBL
Cereblon isoform 4 Cytosolic other Ki 6.10 CHEMBL

External reference:

IDSource
D08976 KEGG_DRUG
4032092 VANDF
CHEBI:72690 CHEBI
CHEMBL43452 ChEMBL_ID
C467566 MESH_SUPPLEMENTAL_RECORD_UI
7348 IUPHAR_LIGAND_ID
DB08910 DRUGBANK_ID
D2UX06XLB5 UNII
1369713 RXNORM
199372 MMSL
29234 MMSL
389764 MMSL
d08041 MMSL
014897 NDDF
703789000 SNOMEDCT_US
703790009 SNOMEDCT_US
C2347624 UMLSCUI
8873 INN_ID
134780 PUBCHEM_CID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Pomalidomide HUMAN PRESCRIPTION DRUG LABEL 1 0480-2601 CAPSULE 3 mg ORAL ANDA 30 sections
Pomalidomide HUMAN PRESCRIPTION DRUG LABEL 1 0480-4018 CAPSULE 1 mg ORAL ANDA 30 sections
Pomalidomide HUMAN PRESCRIPTION DRUG LABEL 1 0480-4022 CAPSULE 2 mg ORAL ANDA 30 sections
Pomalidomide HUMAN PRESCRIPTION DRUG LABEL 1 0480-4035 CAPSULE 4 mg ORAL ANDA 30 sections
Pomalidomide HUMAN PRESCRIPTION DRUG LABEL 1 31722-770 CAPSULE 1 mg ORAL ANDA 30 sections
Pomalidomide HUMAN PRESCRIPTION DRUG LABEL 1 31722-771 CAPSULE 2 mg ORAL ANDA 30 sections
Pomalidomide HUMAN PRESCRIPTION DRUG LABEL 1 31722-772 CAPSULE 3 mg ORAL ANDA 30 sections
Pomalidomide HUMAN PRESCRIPTION DRUG LABEL 1 31722-773 CAPSULE 4 mg ORAL ANDA 30 sections
Pomalidomide HUMAN PRESCRIPTION DRUG LABEL 1 51991-342 CAPSULE 1 mg ORAL ANDA 35 sections
Pomalidomide HUMAN PRESCRIPTION DRUG LABEL 1 51991-343 CAPSULE 2 mg ORAL ANDA 35 sections
Pomalidomide HUMAN PRESCRIPTION DRUG LABEL 1 51991-344 CAPSULE 3 mg ORAL ANDA 35 sections
Pomalidomide HUMAN PRESCRIPTION DRUG LABEL 1 51991-346 CAPSULE 4 mg ORAL ANDA 35 sections
Pomalyst HUMAN PRESCRIPTION DRUG LABEL 1 59572-501 CAPSULE 1 mg ORAL NDA 33 sections
Pomalyst HUMAN PRESCRIPTION DRUG LABEL 1 59572-502 CAPSULE 2 mg ORAL NDA 33 sections
Pomalyst HUMAN PRESCRIPTION DRUG LABEL 1 59572-503 CAPSULE 3 mg ORAL NDA 33 sections
Pomalyst HUMAN PRESCRIPTION DRUG LABEL 1 59572-504 CAPSULE 4 mg ORAL NDA 33 sections
Pomalidomide Human Prescription Drug Label 1 59651-194 CAPSULE 1 mg ORAL ANDA 30 sections
Pomalidomide Human Prescription Drug Label 1 59651-195 CAPSULE 2 mg ORAL ANDA 30 sections
Pomalidomide Human Prescription Drug Label 1 59651-196 CAPSULE 3 mg ORAL ANDA 30 sections
Pomalidomide Human Prescription Drug Label 1 59651-197 CAPSULE 4 mg ORAL ANDA 30 sections
Pomalidomide HUMAN PRESCRIPTION DRUG LABEL 1 60505-4497 CAPSULE 1 mg ORAL ANDA 31 sections
Pomalidomide HUMAN PRESCRIPTION DRUG LABEL 1 60505-4498 CAPSULE 2 mg ORAL ANDA 31 sections
Pomalidomide HUMAN PRESCRIPTION DRUG LABEL 1 60505-4499 CAPSULE 3 mg ORAL ANDA 31 sections
Pomalidomide HUMAN PRESCRIPTION DRUG LABEL 1 60505-4500 CAPSULE 4 mg ORAL ANDA 31 sections
Pomalidomide Human Prescription Drug Label 1 63850-0131 CAPSULE 1 mg ORAL ANDA 29 sections
Pomalidomide Human Prescription Drug Label 1 63850-0132 CAPSULE 2 mg ORAL ANDA 29 sections
Pomalidomide Human Prescription Drug Label 1 63850-0133 CAPSULE 3 mg ORAL ANDA 29 sections
Pomalidomide Human Prescription Drug Label 1 63850-0134 CAPSULE 4 mg ORAL ANDA 29 sections