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pomalidomide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| antineoplastics, thalidomide derivatives | 4746 | 19171-19-8 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
an immunomodulator with antineoplastic and angiogenesis inhibitor activity
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 3 | mg | O |
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| azlogd74 | LogD at pH 7.4 | 0.371 | Moderate | 0.67 | |
| caco2-efflux | Caco-2 efflux ratio (BA/AB) | 2.979 | Moderate | 0.67 | |
| caco2-intrinsic-papp | Caco-2 intrinsic apparent permeability | 31.189 | 10^-6 cm/s | Moderate | 0.67 |
| dh-clint | Dog hepatocyte intrinsic clearance | 2.506 | uL/min/10^6 cells | Moderate | 0.67 |
| dppb | Dog plasma protein binding (% unbound) | 80.690 | % | Moderate | 0.67 |
| fcs-ppb | Fetal calf serum protein binding (% unbound) | 71.900 | % | Moderate | 0.67 |
| herg | hERG pIC50 | 4.267 | pIC50 | Moderate | 0.67 |
| hh-clint | Human hepatocyte intrinsic clearance | 2.118 | uL/min/10^6 cells | Moderate | 0.67 |
| hlm-clint | Human liver microsomal intrinsic clearance | 3.013 | uL/min/mg protein | Moderate | 0.67 |
| hppb | Human plasma protein binding (% unbound) | 77.930 | % | Moderate | 0.67 |
| kinase-safety-class | ACVR2A,ACVR2B,ACVRL1,ALK,AURKA,AURKB,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK1,CDK5,CDK9,CHEK1,CSF1R,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GSK3B,IKBKB,IRAK1,ITK,JAK1,JAK2,KIT,MAP2K6,MAP3K1,MAP3K10,MAP3K11,MAP3K21,MAP3K7,MAP4K1,MAP4K3,MAPK10,MAPK12,MAPK7,MAPK9,MARK4,MELK,MET,MTOR,NTRK2,PAK4,PDK1,PDK2,PDK4,PDPK1,PIK3CB,PIK3CD,PIM2,PLK1,PLK4,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TTK,ULK1,ULK2 | 67 | |||
| kinase-selectivity-class | ACVR2A,ACVR2B,ALK,AURKA,AURKB,AURKC,AXL,BRAF,CAMK2B,CAMK2D,CDK16,CDK4,CDK9,CLK4,DDR1,DYRK1B,EIF2AK3,ERBB2,FLT3,GRK2,GSK3A,GSK3B,HASPIN,INSR,IRAK1,IRAK3,JAK2,MAP2K3,MAP2K6,MAP3K11,MAP3K14,MAP3K21,MAP3K7,MAP4K1,MAPK1,MAPK12,MAPK7,MAPK8,MARK4,MET,MINK1,MTOR,NTRK3,PAK4,PDK1,PIK3CB,PIM3,PRKAA1,PRKDC,SGK1,SIK2,SIK3,STK10,STK17A,STK33,STK4,SYK,TEK,TNIK,TTK,TYRO3,UHMK1,ULK1,ULK2 | 64 | |||
| mdck-mdr1-bcrp-efflux | MDCK-MDR1-BCRP efflux ratio | 1.841 | Moderate | 0.74 | |
| mdck-mdr1-efflux | MDCK-MDR1 efflux ratio | 5.093 | Moderate | 0.67 | |
| mh-clint | Mouse hepatocyte intrinsic clearance | 1.531 | Moderate | 0.67 | |
| mppb | Mouse plasma protein binding (% unbound) | 82.080 | Moderate | 0.67 | |
| nih-mdck-mdr1-efflux | NIH MDCK-MDR1 efflux ratio | 7.096 | Moderate | 0.67 | |
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 | |||
| pld-class | Phospholipidosis risk class (1 = positive, 0 = negative) | 0 | Moderate | 0.74 | |
| pppb | Pig plasma protein binding (% unbound) | 79.740 | % | Moderate | 0.67 |
| rat-kpuu-brain | Rat brain Kpuu | 0.402 | % | Moderate | 0.74 |
| rh-clint | Rat hepatocyte intrinsic clearance | 1.493 | uL/min/10^6 cells | Moderate | 0.67 |
| rh-fuinc | Rat hepatocyte fraction unbound in incubation | 92.430 | % | Moderate | 0.67 |
| rppb | Rat plasma protein binding (% unbound) | 66.310 | % | Moderate | 0.67 |
| solubility-dd | Solubility at pH 7.4 in DMSO | 232.274 | uM | Moderate | 0.67 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| March 26, 2015 | PMDA | CELGENE K.K. | |
| Feb. 8, 2013 | FDA | CELGENE |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Death | 2935.39 | 21.68 | 2630 | 70753 | 453921 | 90101143 |
| White blood cell count decreased | 1933.34 | 21.68 | 1364 | 72019 | 165745 | 90389319 |
| Full blood count decreased | 1710.83 | 21.68 | 707 | 72676 | 28982 | 90526082 |
| Neutropenia | 1509.65 | 21.68 | 1332 | 72051 | 223572 | 90331492 |
| Pneumonia | 1481.23 | 21.68 | 2171 | 71212 | 635888 | 89919176 |
| Neuropathy peripheral | 1293.33 | 21.68 | 990 | 72393 | 135980 | 90419084 |
| Laboratory test abnormal | 835.55 | 21.68 | 483 | 72900 | 41371 | 90513693 |
| Fatigue | 712.63 | 21.68 | 2293 | 71090 | 1151730 | 89403334 |
| Constipation | 558.63 | 21.68 | 892 | 72491 | 279503 | 90275561 |
| Platelet count decreased | 549.39 | 21.68 | 614 | 72769 | 136355 | 90418709 |
| Neutrophil count decreased | 545.99 | 21.68 | 457 | 72926 | 71075 | 90483989 |
| Thrombosis | 542.68 | 21.68 | 460 | 72923 | 72791 | 90482273 |
| Plasma cell myeloma recurrent | 485.79 | 21.68 | 167 | 73216 | 4061 | 90551003 |
| Unevaluable event | 417.60 | 21.68 | 350 | 73033 | 54498 | 90500566 |
| Plasmacytoma | 335.25 | 21.68 | 114 | 73269 | 2679 | 90552385 |
| Human chorionic gonadotropin increased | 325.01 | 21.68 | 102 | 73281 | 1844 | 90553220 |
| Influenza | 321.72 | 21.68 | 475 | 72908 | 138789 | 90416275 |
| Plasma cell myeloma | 307.57 | 21.68 | 259 | 73124 | 40569 | 90514495 |
| COVID-19 | 303.07 | 21.68 | 513 | 72870 | 168330 | 90386734 |
| Cytopenia | 274.68 | 21.68 | 173 | 73210 | 17276 | 90537788 |
| Rheumatoid arthritis | 268.82 | 21.68 | 5 | 73378 | 362609 | 90192455 |
| Condition aggravated | 259.62 | 21.68 | 80 | 73303 | 595465 | 89959599 |
| Tremor | 244.42 | 21.68 | 442 | 72941 | 152731 | 90402333 |
| Urinary tract infection | 232.12 | 21.68 | 656 | 72727 | 304976 | 90250088 |
| Adverse drug reaction | 221.89 | 21.68 | 364 | 73019 | 116337 | 90438727 |
| Product dose omission issue | 218.48 | 21.68 | 623 | 72760 | 291064 | 90264000 |
| Anaemia | 216.93 | 21.68 | 703 | 72680 | 352099 | 90202965 |
| Diarrhoea | 213.38 | 21.68 | 1393 | 71990 | 937797 | 89617267 |
| Pericarditis | 187.96 | 21.68 | 7 | 73376 | 270144 | 90284920 |
| Bronchitis | 181.74 | 21.68 | 390 | 72993 | 152537 | 90402527 |
| Muscle spasms | 180.82 | 21.68 | 530 | 72853 | 251353 | 90303711 |
| Infusion related reaction | 179.64 | 21.68 | 57 | 73326 | 416723 | 90138341 |
| Glossodynia | 177.33 | 21.68 | 25 | 73358 | 321754 | 90233310 |
| Light chain analysis increased | 172.86 | 21.68 | 60 | 73323 | 1502 | 90553562 |
| Asthenia | 169.38 | 21.68 | 866 | 72517 | 532885 | 90022179 |
| Thrombocytopenia | 169.17 | 21.68 | 459 | 72924 | 208266 | 90346798 |
| Helicobacter infection | 164.60 | 21.68 | 4 | 73379 | 226846 | 90328218 |
| Drug hypersensitivity | 163.23 | 21.68 | 86 | 73297 | 463523 | 90091541 |
| Wound | 159.07 | 21.68 | 27 | 73356 | 302953 | 90252111 |
| Atrial fibrillation | 159.03 | 21.68 | 341 | 73042 | 133270 | 90421794 |
| Cardiac disorder | 150.35 | 21.68 | 207 | 73176 | 56665 | 90498399 |
| Sepsis | 146.25 | 21.68 | 396 | 72987 | 179418 | 90375646 |
| Plasma cell myeloma refractory | 146.20 | 21.68 | 48 | 73335 | 1008 | 90554056 |
| Renal disorder | 143.50 | 21.68 | 165 | 73218 | 37694 | 90517370 |
| Folliculitis | 143.15 | 21.68 | 5 | 73378 | 204348 | 90350716 |
| Fibromyalgia | 141.24 | 21.68 | 6 | 73377 | 206263 | 90348801 |
| Impaired healing | 139.36 | 21.68 | 14 | 73369 | 234185 | 90320879 |
| Hepatic enzyme increased | 135.92 | 21.68 | 61 | 73322 | 360675 | 90194389 |
| Drug interaction | 135.84 | 21.68 | 29 | 73354 | 276424 | 90278640 |
| Back pain | 134.00 | 21.68 | 560 | 72823 | 316615 | 90238449 |
| Product use in unapproved indication | 132.85 | 21.68 | 53 | 73330 | 336183 | 90218881 |
| Mobility decreased | 132.36 | 21.68 | 22 | 73361 | 250712 | 90304352 |
| Treatment failure | 130.12 | 21.68 | 42 | 73341 | 303886 | 90251178 |
| Haemoglobin decreased | 129.02 | 21.68 | 354 | 73029 | 161602 | 90393462 |
| Injection site pain | 126.23 | 21.68 | 3 | 73380 | 173696 | 90381368 |
| Red blood cell count decreased | 125.97 | 21.68 | 171 | 73212 | 46180 | 90508884 |
| Liver injury | 123.75 | 21.68 | 3 | 73380 | 170564 | 90384500 |
| Therapeutic product effect decreased | 123.06 | 21.68 | 36 | 73347 | 277535 | 90277529 |
| Discomfort | 119.05 | 21.68 | 37 | 73346 | 274298 | 90280766 |
| Full blood count increased | 115.57 | 21.68 | 42 | 73341 | 1206 | 90553858 |
| Peripheral swelling | 114.34 | 21.68 | 646 | 72737 | 412460 | 90142604 |
| Nasopharyngitis | 114.26 | 21.68 | 639 | 72744 | 406465 | 90148599 |
| Product use issue | 111.97 | 21.68 | 64 | 73319 | 329855 | 90225209 |
| Emergency care examination | 111.82 | 21.68 | 26 | 73357 | 135 | 90554929 |
| Hospitalisation | 111.09 | 21.68 | 289 | 73094 | 127811 | 90427253 |
| Arthralgia | 109.87 | 21.68 | 298 | 73085 | 778224 | 89776840 |
| Dizziness | 108.05 | 21.68 | 831 | 72552 | 588453 | 89966611 |
| Irritable bowel syndrome | 105.56 | 21.68 | 20 | 73363 | 207428 | 90347636 |
| Bone pain | 104.06 | 21.68 | 183 | 73200 | 61800 | 90493264 |
| Deep vein thrombosis | 103.47 | 21.68 | 229 | 73154 | 91391 | 90463673 |
| Fall | 102.97 | 21.68 | 705 | 72678 | 481105 | 90073959 |
| Injury | 102.63 | 21.68 | 18 | 73365 | 197331 | 90357733 |
| Renal failure | 101.98 | 21.68 | 284 | 73099 | 130723 | 90424341 |
| Musculoskeletal stiffness | 99.94 | 21.68 | 58 | 73325 | 296474 | 90258590 |
| Hip fracture | 99.08 | 21.68 | 128 | 73255 | 32949 | 90522115 |
| Wheezing | 98.23 | 21.68 | 35 | 73348 | 238045 | 90317019 |
| Rash | 96.47 | 21.68 | 1026 | 72357 | 795074 | 89759990 |
| Psoriasis | 92.86 | 21.68 | 7 | 73376 | 147747 | 90407317 |
| Osteoarthritis | 91.22 | 21.68 | 23 | 73360 | 195707 | 90359357 |
| Tooth disorder | 91.08 | 21.68 | 119 | 73264 | 30971 | 90524093 |
| Respiratory syncytial virus infection | 90.47 | 21.68 | 72 | 73311 | 10408 | 90544656 |
| Abdominal pain | 87.87 | 21.68 | 115 | 73268 | 395606 | 90159458 |
| Osteolysis | 87.22 | 21.68 | 47 | 73336 | 3503 | 90551561 |
| Drug ineffective | 85.56 | 21.68 | 715 | 72668 | 1383583 | 89171481 |
| Overdose | 85.09 | 21.68 | 13 | 73370 | 157696 | 90397368 |
| Cataract | 84.58 | 21.68 | 183 | 73200 | 71909 | 90483155 |
| Pulmonary thrombosis | 84.00 | 21.68 | 67 | 73316 | 9715 | 90545349 |
| COVID-19 pneumonia | 82.34 | 21.68 | 87 | 73296 | 18090 | 90536974 |
| Full blood count abnormal | 80.34 | 21.68 | 122 | 73261 | 36475 | 90518589 |
| Blood cholesterol increased | 80.15 | 21.68 | 34 | 73349 | 207978 | 90347086 |
| Abdominal discomfort | 78.85 | 21.68 | 168 | 73215 | 477160 | 90077904 |
| Inflammation | 77.60 | 21.68 | 24 | 73359 | 178568 | 90376496 |
| Hypercalcaemia | 69.37 | 21.68 | 110 | 73273 | 34130 | 90520934 |
| Lip dry | 68.87 | 21.68 | 3 | 73380 | 100952 | 90454112 |
| Blister | 68.83 | 21.68 | 63 | 73320 | 254935 | 90300129 |
| Bursitis | 68.45 | 21.68 | 12 | 73371 | 131642 | 90423422 |
| Ill-defined disorder | 68.43 | 21.68 | 32 | 73351 | 184859 | 90370205 |
| Cerebrovascular accident | 67.60 | 21.68 | 237 | 73146 | 123296 | 90431768 |
| Arthropathy | 66.40 | 21.68 | 122 | 73261 | 366120 | 90188944 |
| Illness | 66.04 | 21.68 | 180 | 73203 | 81789 | 90473275 |
| Therapeutic product effect incomplete | 65.19 | 21.68 | 38 | 73345 | 193858 | 90361206 |
| Pulmonary fibrosis | 65.04 | 21.68 | 6 | 73377 | 107497 | 90447567 |
| Sleep disorder | 63.53 | 21.68 | 41 | 73342 | 197989 | 90357075 |
| Immune system disorder | 63.06 | 21.68 | 62 | 73321 | 11843 | 90543221 |
| Pain | 63.01 | 21.68 | 511 | 72872 | 995830 | 89559234 |
| Grip strength decreased | 62.34 | 21.68 | 3 | 73380 | 92573 | 90462491 |
| Injection site reaction | 61.95 | 21.68 | 3 | 73380 | 92077 | 90462987 |
| Product distribution issue | 61.49 | 21.68 | 38 | 73345 | 3667 | 90551397 |
| Musculoskeletal pain | 59.82 | 21.68 | 32 | 73351 | 171219 | 90383845 |
| Blood test abnormal | 59.52 | 21.68 | 79 | 73304 | 20873 | 90534191 |
| Hypersensitivity | 56.77 | 21.68 | 184 | 73199 | 454493 | 90100571 |
| Migraine | 56.34 | 21.68 | 43 | 73340 | 190349 | 90364715 |
| Infection | 55.63 | 21.68 | 491 | 72892 | 361603 | 90193461 |
| Swelling | 55.56 | 21.68 | 165 | 73218 | 418893 | 90136171 |
| Pancytopenia | 55.16 | 21.68 | 218 | 73165 | 120045 | 90435019 |
| Bone lesion | 55.08 | 21.68 | 44 | 73339 | 6393 | 90548671 |
| Crystal nephropathy | 54.90 | 21.68 | 24 | 73359 | 1127 | 90553937 |
| Plasma cell leukaemia | 54.76 | 21.68 | 24 | 73359 | 1134 | 90553930 |
| Headache | 54.71 | 21.68 | 442 | 72941 | 862304 | 89692760 |
| Respiratory tract infection | 53.99 | 21.68 | 136 | 73247 | 58942 | 90496122 |
| Dyspnoea | 52.74 | 21.68 | 1003 | 72380 | 879952 | 89675112 |
| Blood calcium increased | 51.59 | 21.68 | 56 | 73327 | 12002 | 90543062 |
| Epilepsy | 51.34 | 21.68 | 4 | 73379 | 82202 | 90472862 |
| Hypertension | 51.18 | 21.68 | 194 | 73189 | 457338 | 90097726 |
| Wound infection | 50.54 | 21.68 | 12 | 73371 | 106390 | 90448674 |
| Monoclonal immunoglobulin increased | 49.80 | 21.68 | 17 | 73366 | 404 | 90554660 |
| Protein total increased | 48.33 | 21.68 | 32 | 73351 | 3477 | 90551587 |
| Feeling abnormal | 47.78 | 21.68 | 264 | 73119 | 166971 | 90388093 |
| Vision blurred | 47.45 | 21.68 | 196 | 73187 | 110097 | 90444967 |
| Blood potassium decreased | 46.93 | 21.68 | 113 | 73270 | 47614 | 90507450 |
| Product quality issue | 46.49 | 21.68 | 5 | 73378 | 79320 | 90475744 |
| Wrong technique in product usage process | 46.09 | 21.68 | 3 | 73380 | 71568 | 90483496 |
| Multiple allergies | 45.96 | 21.68 | 59 | 73324 | 15087 | 90539977 |
| Paraproteinaemia | 45.13 | 21.68 | 14 | 73369 | 243 | 90554821 |
| Bone marrow disorder | 45.07 | 21.68 | 29 | 73354 | 3003 | 90552061 |
| Vomiting | 44.54 | 21.68 | 416 | 72967 | 787877 | 89767187 |
| General physical health deterioration | 44.10 | 21.68 | 144 | 73239 | 354971 | 90200093 |
| Dehydration | 44.09 | 21.68 | 289 | 73094 | 194158 | 90360906 |
| Tooth infection | 43.93 | 21.68 | 67 | 73316 | 20103 | 90534961 |
| Medication error | 43.39 | 21.68 | 8 | 73375 | 84644 | 90470420 |
| Anaphylactic reaction | 43.32 | 21.68 | 9 | 73374 | 87515 | 90467549 |
| C-reactive protein increased | 43.06 | 21.68 | 50 | 73333 | 181339 | 90373725 |
| Seasonal allergy | 42.70 | 21.68 | 71 | 73312 | 22912 | 90532152 |
| Anxiety | 42.47 | 21.68 | 120 | 73263 | 309652 | 90245412 |
| Balance disorder | 42.14 | 21.68 | 173 | 73210 | 96907 | 90458157 |
| Diverticulitis | 41.26 | 21.68 | 104 | 73279 | 45083 | 90509981 |
| Febrile neutropenia | 40.67 | 21.68 | 243 | 73140 | 158106 | 90396958 |
| Light chain analysis abnormal | 40.56 | 21.68 | 12 | 73371 | 176 | 90554888 |
| Nervousness | 40.56 | 21.68 | 87 | 73296 | 33969 | 90521095 |
| Pneumonia influenzal | 39.80 | 21.68 | 24 | 73359 | 2216 | 90552848 |
| Coronavirus infection | 39.49 | 21.68 | 34 | 73349 | 5481 | 90549583 |
| Intentional product misuse | 38.99 | 21.68 | 12 | 73371 | 89592 | 90465472 |
| Loss of personal independence in daily activities | 38.68 | 21.68 | 32 | 73351 | 136073 | 90418991 |
| Asthma | 38.46 | 21.68 | 87 | 73296 | 242073 | 90312991 |
| Progressive multifocal leukoencephalopathy | 38.41 | 21.68 | 55 | 73328 | 15600 | 90539464 |
| White blood cell count abnormal | 37.75 | 21.68 | 38 | 73345 | 7466 | 90547598 |
| Spinal fracture | 36.93 | 21.68 | 65 | 73318 | 21951 | 90533113 |
| Swelling face | 36.12 | 21.68 | 146 | 73237 | 81206 | 90473858 |
| Inappropriate schedule of product administration | 35.94 | 21.68 | 41 | 73342 | 149892 | 90405172 |
| Leukopenia | 35.75 | 21.68 | 169 | 73214 | 100541 | 90454523 |
| Pneumonia pneumococcal | 35.67 | 21.68 | 24 | 73359 | 2678 | 90552386 |
| Rash pruritic | 35.28 | 21.68 | 146 | 73237 | 82068 | 90472996 |
| Osteoporosis | 35.25 | 21.68 | 17 | 73366 | 96514 | 90458550 |
| Lower respiratory tract infection | 35.17 | 21.68 | 96 | 73287 | 250563 | 90304501 |
| Neutrophil count abnormal | 34.86 | 21.68 | 28 | 73355 | 4100 | 90550964 |
| Localised infection | 34.66 | 21.68 | 81 | 73302 | 33481 | 90521583 |
| Injection site swelling | 34.49 | 21.68 | 4 | 73379 | 59835 | 90495229 |
| Pulmonary embolism | 34.39 | 21.68 | 202 | 73181 | 130618 | 90424446 |
| Foot deformity | 34.35 | 21.68 | 4 | 73379 | 59647 | 90495417 |
| Viral infection | 33.40 | 21.68 | 91 | 73292 | 41323 | 90513741 |
| Coma | 32.93 | 21.68 | 9 | 73374 | 72623 | 90482441 |
| Drug ineffective for unapproved indication | 32.68 | 21.68 | 7 | 73376 | 66637 | 90488427 |
| Liver disorder | 32.65 | 21.68 | 30 | 73353 | 121239 | 90433825 |
| Urticaria | 32.16 | 21.68 | 137 | 73246 | 312597 | 90242467 |
| Pneumonia parainfluenzae viral | 32.15 | 21.68 | 12 | 73371 | 372 | 90554692 |
| Therapy interrupted | 31.71 | 21.68 | 101 | 73282 | 50007 | 90505057 |
| Nail disorder | 31.55 | 21.68 | 5 | 73378 | 59062 | 90496002 |
| Hypogammaglobulinaemia | 31.48 | 21.68 | 41 | 73342 | 10633 | 90544431 |
| Cystitis | 31.44 | 21.68 | 122 | 73261 | 66596 | 90488468 |
| Road traffic accident | 30.96 | 21.68 | 25 | 73358 | 107601 | 90447463 |
| Disease progression | 30.89 | 21.68 | 225 | 73158 | 156390 | 90398674 |
| Rib fracture | 30.87 | 21.68 | 67 | 73316 | 26368 | 90528696 |
| Malaise | 30.56 | 21.68 | 654 | 72729 | 585332 | 89969732 |
| Colitis ulcerative | 30.24 | 21.68 | 6 | 73377 | 60260 | 90494804 |
| Exostosis | 29.53 | 21.68 | 4 | 73379 | 53130 | 90501934 |
| Aspartate aminotransferase increased | 29.49 | 21.68 | 24 | 73359 | 102913 | 90452151 |
| Metabolic acidosis | 29.10 | 21.68 | 5 | 73378 | 55671 | 90499393 |
| Cardiac failure congestive | 28.98 | 21.68 | 157 | 73226 | 98537 | 90456527 |
| Injection site bruising | 28.93 | 21.68 | 4 | 73379 | 52303 | 90502761 |
| Monoclonal immunoglobulin present | 28.36 | 21.68 | 19 | 73364 | 2105 | 90552959 |
| Pathological fracture | 28.33 | 21.68 | 37 | 73346 | 9623 | 90545441 |
| Adverse event | 28.12 | 21.68 | 177 | 73206 | 117241 | 90437823 |
| Joint stiffness | 28.11 | 21.68 | 14 | 73369 | 78028 | 90477036 |
| Natural killer cell count decreased | 27.86 | 21.68 | 8 | 73375 | 105 | 90554959 |
| Dry skin | 27.84 | 21.68 | 143 | 73240 | 87930 | 90467134 |
| Stomatitis | 27.83 | 21.68 | 121 | 73262 | 274577 | 90280487 |
| SARS-CoV-2 test positive | 27.16 | 21.68 | 39 | 73344 | 11089 | 90543975 |
| Onychomadesis | 26.70 | 21.68 | 3 | 73380 | 45995 | 90509069 |
| Alanine aminotransferase increased | 26.62 | 21.68 | 34 | 73349 | 118304 | 90436760 |
| Off label use | 26.47 | 21.68 | 1117 | 72266 | 1101135 | 89453929 |
| Peripheral sensory neuropathy | 26.46 | 21.68 | 35 | 73348 | 9215 | 90545849 |
| Febrile infection | 26.42 | 21.68 | 18 | 73365 | 2051 | 90553013 |
| Sciatica | 26.22 | 21.68 | 26 | 73357 | 101356 | 90453708 |
| Myelosuppression | 26.07 | 21.68 | 99 | 73284 | 53492 | 90501572 |
| Neutropenic sepsis | 25.97 | 21.68 | 50 | 73333 | 18080 | 90536984 |
| JC virus CSF test positive | 25.36 | 21.68 | 6 | 73377 | 34 | 90555030 |
| Feeling jittery | 25.29 | 21.68 | 45 | 73338 | 15326 | 90539738 |
| Eye infection | 25.10 | 21.68 | 43 | 73340 | 14211 | 90540853 |
| Prescribed underdose | 24.78 | 21.68 | 15 | 73368 | 75004 | 90480060 |
| Compression fracture | 24.75 | 21.68 | 33 | 73350 | 8756 | 90546308 |
| Weight decreased | 24.74 | 21.68 | 193 | 73190 | 379717 | 90175347 |
| Gastric disorder | 24.61 | 21.68 | 71 | 73312 | 33313 | 90521751 |
| Stress | 24.56 | 21.68 | 18 | 73365 | 81377 | 90473687 |
| Depression | 24.41 | 21.68 | 143 | 73240 | 300458 | 90254606 |
| Incorrect dose administered | 24.41 | 21.68 | 17 | 73366 | 78913 | 90476151 |
| Musculoskeletal chest pain | 24.17 | 21.68 | 57 | 73326 | 23693 | 90531371 |
| Suicidal ideation | 24.07 | 21.68 | 15 | 73368 | 73840 | 90481224 |
| Kidney infection | 24.03 | 21.68 | 60 | 73323 | 25856 | 90529208 |
| Accidental exposure to product | 24.00 | 21.68 | 3 | 73380 | 42363 | 90512701 |
| Tachycardia | 23.94 | 21.68 | 58 | 73325 | 157615 | 90397449 |
| Eye disorder | 23.93 | 21.68 | 62 | 73321 | 27328 | 90527736 |
| Plasma cells increased | 23.70 | 21.68 | 7 | 73376 | 102 | 90554962 |
| Peritonitis viral | 23.57 | 21.68 | 6 | 73377 | 48 | 90555016 |
| Surgery | 23.53 | 21.68 | 4 | 73379 | 44883 | 90510181 |
| Depressed level of consciousness | 23.42 | 21.68 | 15 | 73368 | 72769 | 90482295 |
| Sleep disorder due to a general medical condition | 23.42 | 21.68 | 4 | 73379 | 44734 | 90510330 |
| Hepatic cirrhosis | 23.31 | 21.68 | 11 | 73372 | 63242 | 90491822 |
| Upper limb fracture | 23.29 | 21.68 | 53 | 73330 | 21525 | 90533539 |
| Night sweats | 23.20 | 21.68 | 43 | 73340 | 128723 | 90426341 |
| Clostridium difficile infection | 22.88 | 21.68 | 73 | 73310 | 36172 | 90518892 |
| Angioedema | 22.82 | 21.68 | 12 | 73371 | 64864 | 90490200 |
| Tumour lysis syndrome | 22.82 | 21.68 | 36 | 73347 | 11116 | 90543948 |
| Agitation | 22.75 | 21.68 | 13 | 73370 | 67085 | 90487979 |
| Rhinovirus infection | 22.61 | 21.68 | 26 | 73357 | 5937 | 90549127 |
| Weight increased | 22.49 | 21.68 | 223 | 73160 | 417704 | 90137360 |
| Delirium | 22.43 | 21.68 | 31 | 73352 | 104328 | 90450736 |
| Hypoaesthesia oral | 22.31 | 21.68 | 43 | 73340 | 15557 | 90539507 |
| Atrial rupture | 22.20 | 21.68 | 6 | 73377 | 62 | 90555002 |
| Jugular vein occlusion | 22.12 | 21.68 | 6 | 73377 | 63 | 90555001 |
| Drug reaction with eosinophilia and systemic symptoms | 22.00 | 21.68 | 4 | 73379 | 42754 | 90512310 |
| Hyponatraemia | 21.99 | 21.68 | 47 | 73336 | 133491 | 90421573 |
| Respiratory tract infection viral | 21.99 | 21.68 | 19 | 73364 | 3077 | 90551987 |
| Dementia | 21.87 | 21.68 | 55 | 73328 | 23806 | 90531258 |
| Sedation | 21.78 | 21.68 | 6 | 73377 | 48165 | 90506899 |
| Upper respiratory tract infection | 21.76 | 21.68 | 178 | 73205 | 128140 | 90426924 |
| Dysphonia | 21.76 | 21.68 | 105 | 73278 | 62979 | 90492085 |
| Blood pressure systolic increased | 21.73 | 21.68 | 10 | 73373 | 58335 | 90496729 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Death | 2644.38 | 17.89 | 3632 | 70631 | 467553 | 42079519 |
| Pneumonia | 1855.91 | 17.89 | 2907 | 71356 | 419242 | 42127830 |
| White blood cell count decreased | 1386.63 | 17.89 | 1301 | 72962 | 109095 | 42437977 |
| Full blood count decreased | 1191.54 | 17.89 | 622 | 73641 | 19938 | 42527134 |
| Fatigue | 1091.35 | 17.89 | 2358 | 71905 | 433283 | 42113789 |
| Laboratory test abnormal | 854.89 | 17.89 | 520 | 73743 | 22458 | 42524614 |
| Neutropenia | 837.82 | 17.89 | 1351 | 72912 | 198080 | 42348992 |
| Neuropathy peripheral | 810.15 | 17.89 | 941 | 73322 | 100912 | 42446160 |
| Adverse drug reaction | 469.94 | 17.89 | 442 | 73821 | 36992 | 42510080 |
| Influenza | 441.87 | 17.89 | 543 | 73720 | 61632 | 42485440 |
| Unevaluable event | 415.38 | 17.89 | 397 | 73866 | 33891 | 42513181 |
| Drug interaction | 377.41 | 17.89 | 22 | 74241 | 266977 | 42280095 |
| Plasma cell myeloma recurrent | 376.17 | 17.89 | 189 | 74074 | 5568 | 42541504 |
| Thrombosis | 358.32 | 17.89 | 515 | 73748 | 67996 | 42479076 |
| Peripheral swelling | 345.91 | 17.89 | 588 | 73675 | 89682 | 42457390 |
| COVID-19 | 331.95 | 17.89 | 666 | 73597 | 115282 | 42431790 |
| Rash | 322.06 | 17.89 | 1136 | 73127 | 275818 | 42271254 |
| Neutrophil count decreased | 308.83 | 17.89 | 461 | 73802 | 62954 | 42484118 |
| Constipation | 299.97 | 17.89 | 784 | 73479 | 161507 | 42385565 |
| Platelet count decreased | 271.00 | 17.89 | 684 | 73579 | 137897 | 42409175 |
| Nasopharyngitis | 239.62 | 17.89 | 482 | 73781 | 83514 | 42463558 |
| Plasmacytoma | 232.66 | 17.89 | 125 | 74138 | 4239 | 42542833 |
| Infection | 225.11 | 17.89 | 559 | 73704 | 111509 | 42435563 |
| Muscle spasms | 211.94 | 17.89 | 465 | 73798 | 85579 | 42461493 |
| Condition aggravated | 202.30 | 17.89 | 101 | 74162 | 260653 | 42286419 |
| Adverse event | 181.67 | 17.89 | 215 | 74048 | 23425 | 42523647 |
| Product use in unapproved indication | 175.17 | 17.89 | 52 | 74211 | 184404 | 42362668 |
| Cardiac disorder | 174.48 | 17.89 | 309 | 73954 | 48623 | 42498449 |
| Plasma cell myeloma refractory | 166.96 | 17.89 | 70 | 74193 | 1340 | 42545732 |
| Plasma cell myeloma | 160.12 | 17.89 | 293 | 73970 | 47285 | 42499787 |
| Completed suicide | 153.19 | 17.89 | 3 | 74260 | 96462 | 42450610 |
| Renal disorder | 153.00 | 17.89 | 219 | 74044 | 28761 | 42518311 |
| Asthenia | 148.95 | 17.89 | 916 | 73347 | 279877 | 42267195 |
| Back pain | 144.37 | 17.89 | 558 | 73705 | 141218 | 42405854 |
| Tooth disorder | 141.74 | 17.89 | 137 | 74126 | 11842 | 42535230 |
| Overdose | 141.66 | 17.89 | 11 | 74252 | 105253 | 42441819 |
| Illness | 126.64 | 17.89 | 185 | 74078 | 24745 | 42522327 |
| Hospitalisation | 122.85 | 17.89 | 345 | 73918 | 73985 | 42473087 |
| Deep vein thrombosis | 118.29 | 17.89 | 348 | 73915 | 76609 | 42470463 |
| Hyponatraemia | 113.37 | 17.89 | 20 | 74243 | 101442 | 42445630 |
| Plasma cell leukaemia | 106.13 | 17.89 | 49 | 74214 | 1191 | 42545881 |
| Product dose omission issue | 105.14 | 17.89 | 539 | 73724 | 153826 | 42393246 |
| Light chain analysis increased | 99.61 | 17.89 | 53 | 74210 | 1761 | 42545311 |
| Sepsis | 99.08 | 17.89 | 640 | 73623 | 198694 | 42348378 |
| Emergency care examination | 98.43 | 17.89 | 21 | 74242 | 20 | 42547052 |
| Bronchitis | 98.37 | 17.89 | 239 | 74024 | 46962 | 42500110 |
| Rhabdomyolysis | 94.92 | 17.89 | 12 | 74251 | 78007 | 42469065 |
| Abdominal pain | 94.25 | 17.89 | 116 | 74147 | 190355 | 42356717 |
| Localised infection | 93.23 | 17.89 | 144 | 74119 | 20229 | 42526843 |
| Cytopenia | 92.00 | 17.89 | 132 | 74131 | 17365 | 42529707 |
| Atrial fibrillation | 85.18 | 17.89 | 473 | 73790 | 139120 | 42407952 |
| Bone pain | 84.44 | 17.89 | 150 | 74113 | 23642 | 42523430 |
| Monoclonal immunoglobulin present | 83.25 | 17.89 | 41 | 74222 | 1155 | 42545917 |
| Vomiting | 83.15 | 17.89 | 245 | 74018 | 289478 | 42257594 |
| Immune system disorder | 82.80 | 17.89 | 75 | 74188 | 5969 | 42541103 |
| Toxicity to various agents | 81.91 | 17.89 | 173 | 74090 | 228963 | 42318109 |
| Injection site pain | 77.84 | 17.89 | 6 | 74257 | 57792 | 42489280 |
| Drug intolerance | 74.88 | 17.89 | 308 | 73955 | 80116 | 42466956 |
| Acute kidney injury | 74.00 | 17.89 | 359 | 73904 | 366978 | 42180094 |
| Aspartate aminotransferase increased | 72.71 | 17.89 | 22 | 74241 | 77141 | 42469931 |
| Full blood count increased | 71.36 | 17.89 | 35 | 74228 | 977 | 42546095 |
| Bone lesion | 68.17 | 17.89 | 53 | 74210 | 3413 | 42543659 |
| Suicidal ideation | 67.78 | 17.89 | 4 | 74259 | 48157 | 42498915 |
| Inappropriate schedule of product administration | 67.21 | 17.89 | 42 | 74221 | 95860 | 42451212 |
| Agitation | 66.96 | 17.89 | 15 | 74248 | 64299 | 42482773 |
| Hypoglycaemia | 66.40 | 17.89 | 12 | 74251 | 59842 | 42487230 |
| Alanine aminotransferase increased | 65.80 | 17.89 | 36 | 74227 | 88370 | 42458702 |
| Hyperkalaemia | 65.58 | 17.89 | 29 | 74234 | 80429 | 42466643 |
| Blood creatine phosphokinase increased | 65.15 | 17.89 | 5 | 74258 | 48333 | 42498739 |
| Ascites | 63.67 | 17.89 | 11 | 74252 | 56667 | 42490405 |
| Red blood cell count decreased | 62.21 | 17.89 | 160 | 74103 | 32555 | 42514517 |
| Fluid retention | 61.53 | 17.89 | 156 | 74107 | 31463 | 42515609 |
| Suicide attempt | 61.48 | 17.89 | 5 | 74258 | 46095 | 42500977 |
| Product distribution issue | 61.22 | 17.89 | 40 | 74223 | 1954 | 42545118 |
| Cataract | 60.61 | 17.89 | 152 | 74111 | 30452 | 42516620 |
| Psoriasis | 60.28 | 17.89 | 7 | 74256 | 48597 | 42498475 |
| Incorrect dose administered | 60.12 | 17.89 | 10 | 74253 | 52964 | 42494108 |
| Sinusitis | 58.95 | 17.89 | 199 | 74064 | 47093 | 42499979 |
| Dizziness | 58.69 | 17.89 | 678 | 73585 | 248576 | 42298496 |
| Rheumatoid arthritis | 58.31 | 17.89 | 4 | 74259 | 42436 | 42504636 |
| Full blood count abnormal | 57.72 | 17.89 | 147 | 74116 | 29729 | 42517343 |
| Coma | 56.74 | 17.89 | 12 | 74251 | 53542 | 42493530 |
| Pulmonary thrombosis | 56.13 | 17.89 | 71 | 74192 | 8277 | 42538795 |
| Dyspnoea | 55.89 | 17.89 | 1081 | 73182 | 441540 | 42105532 |
| Wrong technique in product usage process | 55.83 | 17.89 | 5 | 74258 | 42630 | 42504442 |
| Stress | 55.75 | 17.89 | 6 | 74257 | 44206 | 42502866 |
| Back disorder | 55.50 | 17.89 | 67 | 74196 | 7447 | 42539625 |
| Pneumonia respiratory syncytial viral | 54.67 | 17.89 | 33 | 74230 | 1401 | 42545671 |
| Drug hypersensitivity | 54.05 | 17.89 | 56 | 74207 | 99333 | 42447739 |
| Thrombocytopenia | 53.31 | 17.89 | 536 | 73727 | 189743 | 42357329 |
| IVth nerve paralysis | 52.60 | 17.89 | 24 | 74239 | 567 | 42546505 |
| Hypoaesthesia | 50.28 | 17.89 | 252 | 74011 | 71211 | 42475861 |
| Cellulitis enterococcal | 50.20 | 17.89 | 15 | 74248 | 98 | 42546974 |
| COVID-19 pneumonia | 49.97 | 17.89 | 114 | 74149 | 21499 | 42525573 |
| Anxiety | 48.00 | 17.89 | 83 | 74180 | 118477 | 42428595 |
| White blood cell count abnormal | 46.71 | 17.89 | 44 | 74219 | 3681 | 42543391 |
| Aggression | 46.57 | 17.89 | 10 | 74253 | 44153 | 42502919 |
| Progressive multifocal leukoencephalopathy | 46.54 | 17.89 | 77 | 74186 | 11459 | 42535613 |
| Interstitial lung disease | 46.40 | 17.89 | 41 | 74222 | 78421 | 42468651 |
| Electrocardiogram QT prolonged | 46.39 | 17.89 | 13 | 74250 | 47932 | 42499140 |
| Hypercalcaemia | 45.98 | 17.89 | 99 | 74164 | 17959 | 42529113 |
| Arthropathy | 45.57 | 17.89 | 134 | 74129 | 29463 | 42517609 |
| Hip fracture | 45.32 | 17.89 | 83 | 74180 | 13389 | 42533683 |
| Haematuria | 45.28 | 17.89 | 22 | 74241 | 57777 | 42489295 |
| Pancreatitis | 45.22 | 17.89 | 10 | 74253 | 43258 | 42503814 |
| Respiratory syncytial virus infection | 45.22 | 17.89 | 59 | 74204 | 7093 | 42539979 |
| International normalised ratio increased | 44.89 | 17.89 | 14 | 74249 | 48154 | 42498918 |
| Hypotension | 44.45 | 17.89 | 265 | 73998 | 257366 | 42289706 |
| Lactic acidosis | 44.30 | 17.89 | 12 | 74251 | 45249 | 42501823 |
| Drug-induced liver injury | 43.93 | 17.89 | 7 | 74256 | 38266 | 42508806 |
| Seizure | 43.03 | 17.89 | 91 | 74172 | 120470 | 42426602 |
| Blood test abnormal | 42.77 | 17.89 | 79 | 74184 | 12827 | 42534245 |
| Melaena | 42.47 | 17.89 | 8 | 74255 | 38738 | 42508334 |
| Bradycardia | 42.29 | 17.89 | 52 | 74211 | 85432 | 42461640 |
| Drug reaction with eosinophilia and systemic symptoms | 41.47 | 17.89 | 11 | 74252 | 42064 | 42505008 |
| Oxygen saturation decreased | 40.46 | 17.89 | 32 | 74231 | 64655 | 42482417 |
| Hypokalaemia | 39.45 | 17.89 | 40 | 74223 | 71681 | 42475391 |
| Psychotic disorder | 39.41 | 17.89 | 3 | 74260 | 29205 | 42517867 |
| Monoclonal immunoglobulin increased | 39.27 | 17.89 | 18 | 74245 | 430 | 42546642 |
| Sedation | 38.77 | 17.89 | 4 | 74259 | 30471 | 42516601 |
| Balance disorder | 38.58 | 17.89 | 175 | 74088 | 47470 | 42499602 |
| Angioedema | 38.43 | 17.89 | 13 | 74250 | 42464 | 42504608 |
| Dysarthria | 38.13 | 17.89 | 11 | 74252 | 39796 | 42507276 |
| Rib fracture | 37.86 | 17.89 | 87 | 74176 | 16484 | 42530588 |
| Diarrhoea | 37.79 | 17.89 | 1060 | 73203 | 459789 | 42087283 |
| Loss of personal independence in daily activities | 37.47 | 17.89 | 20 | 74243 | 49796 | 42497276 |
| Anaphylactic reaction | 37.10 | 17.89 | 14 | 74249 | 42729 | 42504343 |
| Respiratory tract infection | 36.61 | 17.89 | 115 | 74148 | 26207 | 42520865 |
| Pancytopenia | 36.53 | 17.89 | 339 | 73924 | 117404 | 42429668 |
| Medication error | 36.01 | 17.89 | 7 | 74256 | 33147 | 42513925 |
| Drug ineffective for unapproved indication | 35.51 | 17.89 | 18 | 74245 | 46145 | 42500927 |
| Therapeutic product effect incomplete | 35.24 | 17.89 | 43 | 74220 | 70896 | 42476176 |
| Fall | 34.83 | 17.89 | 588 | 73675 | 233932 | 42313140 |
| Blood bilirubin increased | 34.78 | 17.89 | 15 | 74248 | 42237 | 42504835 |
| Cardiac arrest | 34.60 | 17.89 | 88 | 74175 | 109232 | 42437840 |
| Parainfluenzae virus infection | 34.58 | 17.89 | 37 | 74226 | 3606 | 42543466 |
| Epilepsy | 34.45 | 17.89 | 3 | 74260 | 26168 | 42520904 |
| Coronary artery disease | 34.33 | 17.89 | 26 | 74237 | 53694 | 42493378 |
| Upper respiratory tract infection | 34.22 | 17.89 | 155 | 74108 | 42018 | 42505054 |
| Asthma | 33.99 | 17.89 | 35 | 74228 | 62279 | 42484793 |
| Cardiogenic shock | 33.86 | 17.89 | 10 | 74253 | 35630 | 42511442 |
| Cholestasis | 33.56 | 17.89 | 8 | 74255 | 32871 | 42514201 |
| Gastric disorder | 33.43 | 17.89 | 68 | 74195 | 11854 | 42535218 |
| Protein total increased | 33.38 | 17.89 | 31 | 74232 | 2547 | 42544525 |
| Metabolic acidosis | 33.26 | 17.89 | 25 | 74238 | 51833 | 42495239 |
| Tooth infection | 33.03 | 17.89 | 54 | 74209 | 7957 | 42539115 |
| Gamma-glutamyltransferase increased | 32.98 | 17.89 | 8 | 74255 | 32489 | 42514583 |
| Feeling abnormal | 32.70 | 17.89 | 221 | 74042 | 69565 | 42477507 |
| Squamous cell carcinoma of skin | 32.66 | 17.89 | 70 | 74193 | 12656 | 42534416 |
| Upper limb fracture | 32.31 | 17.89 | 44 | 74219 | 5512 | 42541560 |
| Keratopathy | 31.72 | 17.89 | 18 | 74245 | 680 | 42546392 |
| Pyrexia | 31.60 | 17.89 | 904 | 73359 | 393138 | 42153934 |
| Blood urea increased | 31.52 | 17.89 | 9 | 74254 | 32784 | 42514288 |
| Gastrointestinal haemorrhage | 31.44 | 17.89 | 78 | 74185 | 97648 | 42449424 |
| Tremor | 31.04 | 17.89 | 281 | 73982 | 96648 | 42450424 |
| Body height decreased | 31.00 | 17.89 | 37 | 74226 | 4063 | 42543009 |
| Pathological fracture | 30.90 | 17.89 | 42 | 74221 | 5251 | 42541821 |
| Tachycardia | 30.74 | 17.89 | 83 | 74180 | 101004 | 42446068 |
| White blood cell disorder | 30.65 | 17.89 | 26 | 74237 | 1895 | 42545177 |
| SARS-CoV-2 test positive | 30.49 | 17.89 | 53 | 74210 | 8207 | 42538865 |
| Blood pressure systolic increased | 30.18 | 17.89 | 6 | 74257 | 27962 | 42519110 |
| Anaphylactic shock | 30.14 | 17.89 | 3 | 74260 | 23514 | 42523558 |
| Eczema | 29.86 | 17.89 | 11 | 74252 | 34075 | 42512997 |
| Headache | 29.81 | 17.89 | 270 | 73993 | 239099 | 42307973 |
| JC virus infection | 29.38 | 17.89 | 31 | 74232 | 2973 | 42544099 |
| Blood creatinine increased | 29.35 | 17.89 | 96 | 74167 | 109907 | 42437165 |
| Haematochezia | 28.42 | 17.89 | 36 | 74227 | 58400 | 42488672 |
| Neutropenic sepsis | 28.28 | 17.89 | 76 | 74187 | 15870 | 42531202 |
| Rhinovirus infection | 28.17 | 17.89 | 45 | 74218 | 6503 | 42540569 |
| Paraproteinaemia | 28.08 | 17.89 | 14 | 74249 | 405 | 42546667 |
| Generalised tonic-clonic seizure | 27.76 | 17.89 | 6 | 74257 | 26373 | 42520699 |
| Musculoskeletal disorder | 27.71 | 17.89 | 45 | 74218 | 6593 | 42540479 |
| Ventricular tachycardia | 27.68 | 17.89 | 9 | 74254 | 30151 | 42516921 |
| Jaundice | 27.34 | 17.89 | 13 | 74250 | 34576 | 42512496 |
| Blood lactate dehydrogenase increased | 27.31 | 17.89 | 6 | 74257 | 26075 | 42520997 |
| Malaise | 27.26 | 17.89 | 520 | 73743 | 211636 | 42335436 |
| Blood immunoglobulin M increased | 27.00 | 17.89 | 12 | 74251 | 266 | 42546806 |
| Hepatic function abnormal | 26.97 | 17.89 | 30 | 74233 | 51537 | 42495535 |
| Hyperlipidaemia | 26.92 | 17.89 | 3 | 74260 | 21513 | 42525559 |
| Lower limb fracture | 26.88 | 17.89 | 38 | 74225 | 4929 | 42542143 |
| Agranulocytosis | 26.61 | 17.89 | 10 | 74253 | 30602 | 42516470 |
| Eosinophilia | 26.57 | 17.89 | 12 | 74251 | 32887 | 42514185 |
| Osteolysis | 26.57 | 17.89 | 32 | 74231 | 3548 | 42543524 |
| Shock | 26.19 | 17.89 | 9 | 74254 | 29112 | 42517960 |
| C-reactive protein increased | 26.16 | 17.89 | 44 | 74219 | 63516 | 42483556 |
| Treatment failure | 26.10 | 17.89 | 43 | 74220 | 62581 | 42484491 |
| Haematemesis | 26.03 | 17.89 | 10 | 74253 | 30189 | 42516883 |
| Coronavirus infection | 25.47 | 17.89 | 38 | 74225 | 5176 | 42541896 |
| Therapy interrupted | 25.43 | 17.89 | 91 | 74172 | 22159 | 42524913 |
| Rash pruritic | 25.41 | 17.89 | 121 | 74142 | 33482 | 42513590 |
| Leukocytosis | 25.33 | 17.89 | 10 | 74253 | 29698 | 42517374 |
| Arthralgia | 25.33 | 17.89 | 232 | 74031 | 205006 | 42342066 |
| Transaminases increased | 25.03 | 17.89 | 13 | 74250 | 32872 | 42514200 |
| Lymphodepletion | 25.00 | 17.89 | 7 | 74256 | 35 | 42547037 |
| Injection site erythema | 24.81 | 17.89 | 3 | 74260 | 20192 | 42526880 |
| Blood immunoglobulin A increased | 24.79 | 17.89 | 13 | 74250 | 419 | 42546653 |
| General physical health deterioration | 24.78 | 17.89 | 158 | 74105 | 151088 | 42395984 |
| Rectal haemorrhage | 24.71 | 17.89 | 30 | 74233 | 49576 | 42497496 |
| Lower respiratory tract infection | 24.66 | 17.89 | 139 | 74124 | 41067 | 42506005 |
| Blood alkaline phosphatase increased | 24.52 | 17.89 | 14 | 74249 | 33583 | 42513489 |
| Dyskinesia | 24.34 | 17.89 | 7 | 74256 | 25383 | 42521689 |
| Ventricular fibrillation | 24.31 | 17.89 | 11 | 74252 | 30112 | 42516960 |
| Mucosal inflammation | 23.41 | 17.89 | 31 | 74232 | 49343 | 42497729 |
| Pneumocystis jirovecii pneumonia | 23.06 | 17.89 | 96 | 74167 | 25085 | 42521987 |
| Spinal fracture | 22.95 | 17.89 | 50 | 74213 | 9140 | 42537932 |
| Toxic epidermal necrolysis | 22.82 | 17.89 | 9 | 74254 | 26741 | 42520331 |
| Protein total abnormal | 22.71 | 17.89 | 12 | 74251 | 393 | 42546679 |
| Pneumonia influenzal | 22.70 | 17.89 | 22 | 74241 | 1907 | 42545165 |
| Proteinuria | 22.66 | 17.89 | 6 | 74257 | 22977 | 42524095 |
| Cerebrovascular accident | 22.66 | 17.89 | 264 | 73999 | 96896 | 42450176 |
| Hypothyroidism | 22.53 | 17.89 | 14 | 74249 | 32070 | 42515002 |
| Pleural effusion | 22.48 | 17.89 | 90 | 74173 | 97076 | 42449996 |
| Multiple allergies | 22.40 | 17.89 | 30 | 74233 | 3698 | 42543374 |
| Arteriosclerosis coronary artery | 22.40 | 17.89 | 3 | 74260 | 18674 | 42528398 |
| IgA nephropathy | 22.34 | 17.89 | 24 | 74239 | 2350 | 42544722 |
| Listeriosis | 22.31 | 17.89 | 19 | 74244 | 1392 | 42545680 |
| Vertebral lesion | 22.20 | 17.89 | 10 | 74253 | 229 | 42546843 |
| Haemoglobin decreased | 22.20 | 17.89 | 339 | 73924 | 132132 | 42414940 |
| Swelling face | 22.14 | 17.89 | 101 | 74162 | 27453 | 42519619 |
| Hypomagnesaemia | 22.07 | 17.89 | 11 | 74252 | 28477 | 42518595 |
| Clostridium difficile infection | 22.03 | 17.89 | 88 | 74175 | 22571 | 42524501 |
| Respiration abnormal | 21.99 | 17.89 | 31 | 74232 | 4011 | 42543061 |
| Respiratory arrest | 21.99 | 17.89 | 11 | 74252 | 28413 | 42518659 |
| Amnesia | 21.94 | 17.89 | 103 | 74160 | 28334 | 42518738 |
| Product prescribing error | 21.92 | 17.89 | 9 | 74254 | 26103 | 42520969 |
| Circulatory collapse | 21.79 | 17.89 | 7 | 74256 | 23629 | 42523443 |
| Spinal disorder | 21.77 | 17.89 | 33 | 74230 | 4558 | 42542514 |
| Benign prostatic hyperplasia | 21.72 | 17.89 | 5 | 74258 | 21047 | 42526025 |
| Altered state of consciousness | 21.63 | 17.89 | 12 | 74251 | 29247 | 42517825 |
| Stevens-Johnson syndrome | 21.47 | 17.89 | 6 | 74257 | 22172 | 42524900 |
| H1N1 influenza | 21.17 | 17.89 | 17 | 74246 | 1147 | 42545925 |
| Cerebral toxoplasmosis | 21.14 | 17.89 | 22 | 74241 | 2076 | 42544996 |
| Product quality issue | 21.14 | 17.89 | 3 | 74260 | 17879 | 42529193 |
| Sleep disorder | 21.01 | 17.89 | 32 | 74231 | 48063 | 42499009 |
| Abnormal behaviour | 20.82 | 17.89 | 10 | 74253 | 26441 | 42520631 |
| Viral infection | 20.81 | 17.89 | 86 | 74177 | 22397 | 42524675 |
| Surgery | 20.72 | 17.89 | 3 | 74260 | 17613 | 42529459 |
| White blood cell count increased | 20.68 | 17.89 | 29 | 74234 | 45058 | 42502014 |
| Hepatic enzyme increased | 20.45 | 17.89 | 30 | 74233 | 45754 | 42501318 |
| Sinus disorder | 20.34 | 17.89 | 44 | 74219 | 8006 | 42539066 |
| Drug ineffective | 20.33 | 17.89 | 895 | 73368 | 629302 | 41917770 |
| Unresponsive to stimuli | 20.32 | 17.89 | 15 | 74248 | 31388 | 42515684 |
| Musculoskeletal stiffness | 20.26 | 17.89 | 44 | 74219 | 57721 | 42489351 |
| Lymphadenopathy | 20.24 | 17.89 | 17 | 74246 | 33348 | 42513724 |
| Urinary tract infection | 20.22 | 17.89 | 263 | 74000 | 99021 | 42448051 |
| Restlessness | 20.21 | 17.89 | 13 | 74250 | 29236 | 42517836 |
| Diabetic ketoacidosis | 19.96 | 17.89 | 7 | 74256 | 22360 | 42524712 |
| Hypoacusis | 19.29 | 17.89 | 74 | 74189 | 18628 | 42528444 |
| Ageusia | 19.27 | 17.89 | 54 | 74209 | 11551 | 42535521 |
| Blood pressure abnormal | 19.10 | 17.89 | 49 | 74214 | 9949 | 42537123 |
| Mobility decreased | 19.06 | 17.89 | 20 | 74243 | 35286 | 42511786 |
| Wheezing | 18.99 | 17.89 | 42 | 74221 | 54739 | 42492333 |
| Haemoptysis | 18.96 | 17.89 | 32 | 74231 | 46135 | 42500937 |
| Depression | 18.92 | 17.89 | 115 | 74148 | 111248 | 42435824 |
| Neoplasm | 18.92 | 17.89 | 37 | 74226 | 6268 | 42540804 |
| Bone disorder | 18.87 | 17.89 | 38 | 74225 | 6575 | 42540497 |
| Nightmare | 18.87 | 17.89 | 10 | 74253 | 25002 | 42522070 |
| Myocardial ischaemia | 18.77 | 17.89 | 4 | 74259 | 17758 | 42529314 |
| Metastases to liver | 18.70 | 17.89 | 3 | 74260 | 16323 | 42530749 |
| Gallbladder disorder | 18.55 | 17.89 | 40 | 74223 | 7262 | 42539810 |
| Encephalopathy | 18.54 | 17.89 | 27 | 74236 | 41306 | 42505766 |
| Seasonal allergy | 18.08 | 17.89 | 42 | 74221 | 8013 | 42539059 |
| Osteoarthritis | 18.06 | 17.89 | 10 | 74253 | 24395 | 42522677 |
| Cardio-respiratory arrest | 17.93 | 17.89 | 48 | 74215 | 58588 | 42488484 |
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Death | 5083.52 | 18.94 | 4526 | 95736 | 694343 | 109794694 |
| Pneumonia | 2795.22 | 18.94 | 3679 | 96583 | 873035 | 109616002 |
| Neutropenia | 2437.18 | 18.94 | 2289 | 97973 | 372331 | 110116706 |
| White blood cell count decreased | 2095.08 | 18.94 | 1702 | 98560 | 227688 | 110261349 |
| Full blood count decreased | 1666.73 | 18.94 | 734 | 99528 | 31365 | 110457672 |
| Neuropathy peripheral | 1289.22 | 18.94 | 1161 | 99101 | 178116 | 110310921 |
| Fatigue | 907.11 | 18.94 | 2779 | 97483 | 1213179 | 109275858 |
| Neutrophil count decreased | 830.94 | 18.94 | 764 | 99498 | 120177 | 110368860 |
| Platelet count decreased | 734.18 | 18.94 | 972 | 99290 | 229471 | 110259566 |
| Plasma cell myeloma recurrent | 677.25 | 18.94 | 251 | 100011 | 6791 | 110482246 |
| Thrombosis | 598.35 | 18.94 | 608 | 99654 | 108054 | 110380983 |
| Plasma cell myeloma | 551.69 | 18.94 | 457 | 99805 | 62479 | 110426558 |
| Laboratory test abnormal | 543.64 | 18.94 | 392 | 99870 | 43687 | 110445350 |
| COVID-19 | 489.26 | 18.94 | 831 | 99431 | 244229 | 110244808 |
| Hospitalisation | 474.99 | 18.94 | 615 | 99647 | 141878 | 110347159 |
| Plasmacytoma | 460.32 | 18.94 | 175 | 100087 | 5087 | 110483950 |
| Constipation | 416.80 | 18.94 | 968 | 99294 | 356818 | 110132219 |
| Influenza | 413.38 | 18.94 | 629 | 99633 | 168472 | 110320565 |
| Thrombocytopenia | 351.80 | 18.94 | 893 | 99369 | 347992 | 110141045 |
| Sepsis | 349.10 | 18.94 | 856 | 99406 | 326490 | 110162547 |
| Unevaluable event | 345.31 | 18.94 | 342 | 99920 | 58885 | 110430152 |
| Cytopenia | 335.60 | 18.94 | 252 | 100010 | 29864 | 110459173 |
| Drug interaction | 334.88 | 18.94 | 33 | 100229 | 500150 | 109988887 |
| Rash | 306.89 | 18.94 | 1512 | 98750 | 819452 | 109669585 |
| Anaemia | 300.96 | 18.94 | 1133 | 99129 | 545953 | 109943084 |
| Deep vein thrombosis | 289.00 | 18.94 | 482 | 99780 | 139405 | 110349632 |
| Plasma cell myeloma refractory | 286.86 | 18.94 | 96 | 100166 | 1905 | 110487132 |
| Condition aggravated | 277.84 | 18.94 | 161 | 100101 | 734675 | 109754362 |
| Human chorionic gonadotropin increased | 257.92 | 18.94 | 83 | 100179 | 1449 | 110487588 |
| Atrial fibrillation | 247.23 | 18.94 | 603 | 99659 | 229039 | 110259998 |
| Rheumatoid arthritis | 243.11 | 18.94 | 6 | 100256 | 299607 | 110189430 |
| Drug hypersensitivity | 214.72 | 18.94 | 72 | 100190 | 454018 | 110035019 |
| Light chain analysis increased | 208.43 | 18.94 | 79 | 100183 | 2276 | 110486761 |
| Emergency care examination | 199.37 | 18.94 | 46 | 100216 | 200 | 110488837 |
| Product dose omission issue | 193.07 | 18.94 | 686 | 99576 | 321096 | 110167941 |
| Plasma cell leukaemia | 191.89 | 18.94 | 72 | 100190 | 2016 | 110487021 |
| Adverse event | 168.61 | 18.94 | 331 | 99931 | 108478 | 110380559 |
| Muscle spasms | 165.95 | 18.94 | 592 | 99670 | 277565 | 110211472 |
| Product use in unapproved indication | 163.26 | 18.94 | 102 | 100160 | 447275 | 110041762 |
| Bronchitis | 160.08 | 18.94 | 404 | 99858 | 156628 | 110332409 |
| Pericarditis | 158.94 | 18.94 | 10 | 100252 | 219104 | 110269933 |
| Glossodynia | 155.61 | 18.94 | 12 | 100250 | 221992 | 110267045 |
| Urinary tract infection | 155 | 18.94 | 646 | 99616 | 325636 | 110163401 |
| Cardiac disorder | 153.66 | 18.94 | 260 | 100002 | 76020 | 110413017 |
| Off label use | 149.03 | 18.94 | 2039 | 98223 | 1498146 | 108990891 |
| Overdose | 147.32 | 18.94 | 19 | 100243 | 233775 | 110255262 |
| Asthenia | 143.71 | 18.94 | 1092 | 99170 | 687907 | 109801130 |
| COVID-19 pneumonia | 142.26 | 18.94 | 172 | 100090 | 36971 | 110452066 |
| Fibromyalgia | 140.23 | 18.94 | 3 | 100259 | 170906 | 110318131 |
| Product distribution issue | 138.26 | 18.94 | 71 | 100191 | 4275 | 110484762 |
| Infection | 136.03 | 18.94 | 669 | 99593 | 361531 | 110127506 |
| Abdominal pain | 135.90 | 18.94 | 159 | 100103 | 512830 | 109976207 |
| Therapeutic product effect decreased | 135.78 | 18.94 | 28 | 100234 | 244288 | 110244749 |
| Musculoskeletal stiffness | 134.59 | 18.94 | 43 | 100219 | 279779 | 110209258 |
| Diarrhoea | 132.86 | 18.94 | 1596 | 98666 | 1137909 | 109351128 |
| Bone pain | 131.17 | 18.94 | 222 | 100040 | 64911 | 110424126 |
| Arthralgia | 130.05 | 18.94 | 325 | 99937 | 779307 | 109709730 |
| Folliculitis | 130.03 | 18.94 | 5 | 100257 | 167648 | 110321389 |
| Type 2 diabetes mellitus | 128.80 | 18.94 | 8 | 100254 | 177224 | 110311813 |
| Renal disorder | 127.79 | 18.94 | 189 | 100073 | 49290 | 110439747 |
| Injection site pain | 126.45 | 18.94 | 9 | 100253 | 177913 | 110311124 |
| Wound | 125.95 | 18.94 | 29 | 100233 | 234408 | 110254629 |
| Hypercalcaemia | 124.52 | 18.94 | 181 | 100081 | 46476 | 110442561 |
| Hepatic enzyme increased | 124.33 | 18.94 | 68 | 100194 | 320824 | 110168213 |
| Peripheral swelling | 123.47 | 18.94 | 705 | 99557 | 403329 | 110085708 |
| Pancytopenia | 123.14 | 18.94 | 444 | 99818 | 209169 | 110279868 |
| Red blood cell count decreased | 121.41 | 18.94 | 216 | 100046 | 65707 | 110423330 |
| Mobility decreased | 120.53 | 18.94 | 33 | 100229 | 237389 | 110251648 |
| Respiratory syncytial virus infection | 120.27 | 18.94 | 102 | 100160 | 14382 | 110474655 |
| Impaired healing | 119.20 | 18.94 | 18 | 100244 | 196699 | 110292338 |
| Wheezing | 114.53 | 18.94 | 44 | 100218 | 255186 | 110233851 |
| Pulmonary thrombosis | 113.83 | 18.94 | 97 | 100165 | 13766 | 110475271 |
| Tremor | 111.76 | 18.94 | 420 | 99842 | 201812 | 110287225 |
| Blood cholesterol increased | 111.75 | 18.94 | 17 | 100245 | 184768 | 110304269 |
| Discomfort | 110.58 | 18.94 | 29 | 100233 | 214678 | 110274359 |
| Therapy interrupted | 109.99 | 18.94 | 177 | 100085 | 49645 | 110439392 |
| Treatment failure | 109.96 | 18.94 | 57 | 100205 | 277177 | 110211860 |
| Muscle injury | 109.88 | 18.94 | 4 | 100258 | 140803 | 110348234 |
| Febrile neutropenia | 109.01 | 18.94 | 571 | 99691 | 316196 | 110172841 |
| Osteoarthritis | 107.74 | 18.94 | 18 | 100244 | 182605 | 110306432 |
| Haemoglobin decreased | 106.94 | 18.94 | 478 | 99784 | 248249 | 110240788 |
| Irritable bowel syndrome | 106.76 | 18.94 | 12 | 100250 | 164203 | 110324834 |
| Liver injury | 105.76 | 18.94 | 8 | 100254 | 150405 | 110338632 |
| Inflammation | 99.70 | 18.94 | 26 | 100236 | 193212 | 110295825 |
| Progressive multifocal leukoencephalopathy | 99.56 | 18.94 | 118 | 100144 | 24838 | 110464199 |
| Injury | 99.13 | 18.94 | 20 | 100242 | 177245 | 110311792 |
| Renal failure | 98.57 | 18.94 | 437 | 99825 | 226137 | 110262900 |
| Headache | 98.20 | 18.94 | 439 | 99823 | 881938 | 109607099 |
| Ill-defined disorder | 98.19 | 18.94 | 13 | 100249 | 156840 | 110332197 |
| Infusion related reaction | 97.84 | 18.94 | 121 | 100141 | 381041 | 110107996 |
| Psoriasis | 96.88 | 18.94 | 8 | 100254 | 139985 | 110349052 |
| Hip fracture | 96.18 | 18.94 | 138 | 100124 | 35013 | 110454024 |
| Fall | 94.70 | 18.94 | 898 | 99364 | 602584 | 109886453 |
| Vomiting | 93.75 | 18.94 | 466 | 99796 | 910209 | 109578828 |
| Back pain | 92.27 | 18.94 | 614 | 99648 | 370382 | 110118655 |
| Bursitis | 91.09 | 18.94 | 7 | 100255 | 129911 | 110359126 |
| Cerebrovascular accident | 90.78 | 18.94 | 365 | 99897 | 180919 | 110308118 |
| Respiratory tract infection | 90.02 | 18.94 | 200 | 100062 | 71417 | 110417620 |
| Osteolysis | 89.10 | 18.94 | 58 | 100204 | 5465 | 110483572 |
| Neutropenic sepsis | 89.00 | 18.94 | 124 | 100138 | 30622 | 110458415 |
| Anxiety | 78.05 | 18.94 | 120 | 100142 | 344958 | 110144079 |
| Drug-induced liver injury | 77.47 | 18.94 | 9 | 100253 | 120058 | 110368979 |
| Pyrexia | 76.82 | 18.94 | 1191 | 99071 | 897074 | 109591963 |
| Intentional product misuse | 76.41 | 18.94 | 14 | 100248 | 132890 | 110356147 |
| Adverse drug reaction | 75.54 | 18.94 | 239 | 100023 | 105320 | 110383717 |
| Lip dry | 74.29 | 18.94 | 4 | 100258 | 100079 | 110388958 |
| Paraproteinaemia | 73.78 | 18.94 | 25 | 100237 | 516 | 110488521 |
| Blister | 73.44 | 18.94 | 59 | 100203 | 227317 | 110261720 |
| Stress | 72.95 | 18.94 | 6 | 100256 | 105342 | 110383695 |
| Dizziness | 72.93 | 18.94 | 959 | 99303 | 697234 | 109791803 |
| Pulmonary embolism | 71.93 | 18.94 | 384 | 99878 | 214090 | 110274947 |
| Suicide attempt | 71.29 | 18.94 | 6 | 100256 | 103388 | 110385649 |
| Leukopenia | 70.85 | 18.94 | 295 | 99967 | 148496 | 110340541 |
| Sleep disorder | 70.05 | 18.94 | 47 | 100215 | 198597 | 110290440 |
| Abdominal discomfort | 69.64 | 18.94 | 159 | 100103 | 393699 | 110095338 |
| Injection site erythema | 69.17 | 18.94 | 4 | 100258 | 94172 | 110394865 |
| Rhabdomyolysis | 68.54 | 18.94 | 13 | 100249 | 120388 | 110368649 |
| Tooth disorder | 68.11 | 18.94 | 107 | 100155 | 29402 | 110459635 |
| Pneumonia respiratory syncytial viral | 68.03 | 18.94 | 38 | 100224 | 2711 | 110486326 |
| Musculoskeletal pain | 66.30 | 18.94 | 42 | 100220 | 182981 | 110306056 |
| Epilepsy | 65.94 | 18.94 | 7 | 100255 | 100202 | 110388835 |
| Migraine | 65.54 | 18.94 | 37 | 100225 | 171615 | 110317422 |
| Bone lesion | 65.27 | 18.94 | 53 | 100209 | 7034 | 110482003 |
| IVth nerve paralysis | 65.24 | 18.94 | 24 | 100238 | 635 | 110488402 |
| Asthma | 64.67 | 18.94 | 79 | 100183 | 250212 | 110238825 |
| Pathological fracture | 63.73 | 18.94 | 66 | 100196 | 11966 | 110477071 |
| Peripheral venous disease | 63.58 | 18.94 | 3 | 100259 | 84114 | 110404923 |
| Illness | 63.39 | 18.94 | 191 | 100071 | 81980 | 110407057 |
| Wrong technique in product usage process | 63.28 | 18.94 | 4 | 100258 | 87344 | 110401693 |
| Squamous cell carcinoma of skin | 63.17 | 18.94 | 78 | 100184 | 17125 | 110471912 |
| Medication error | 63.00 | 18.94 | 10 | 100252 | 105356 | 110383681 |
| Weight increased | 62.99 | 18.94 | 184 | 100078 | 419460 | 110069577 |
| Hypertension | 62.68 | 18.94 | 244 | 100018 | 509840 | 109979197 |
| Hyponatraemia | 61.35 | 18.94 | 64 | 100198 | 217589 | 110271448 |
| Dyspnoea | 61.31 | 18.94 | 1372 | 98890 | 1105500 | 109383537 |
| Coma | 60.52 | 18.94 | 16 | 100246 | 117853 | 110371184 |
| White blood cell count abnormal | 60.14 | 18.94 | 50 | 100212 | 6859 | 110482178 |
| Nasopharyngitis | 59.36 | 18.94 | 582 | 99680 | 393779 | 110095258 |
| Prescribed overdose | 57.93 | 18.94 | 6 | 100256 | 87575 | 110401462 |
| Product quality issue | 57.65 | 18.94 | 3 | 100259 | 77296 | 110411741 |
| Arthropathy | 57.63 | 18.94 | 108 | 100154 | 287414 | 110201623 |
| Grip strength decreased | 57.11 | 18.94 | 4 | 100258 | 80170 | 110408867 |
| Product use issue | 56.57 | 18.94 | 124 | 100138 | 311571 | 110177466 |
| Pulmonary fibrosis | 56.04 | 18.94 | 12 | 100250 | 102030 | 110387007 |
| Hypogammaglobulinaemia | 55.19 | 18.94 | 79 | 100183 | 19997 | 110469040 |
| Pain | 55.06 | 18.94 | 577 | 99685 | 954378 | 109534659 |
| Agitation | 54.99 | 18.94 | 17 | 100245 | 113034 | 110376003 |
| Colitis ulcerative | 54.70 | 18.94 | 4 | 100258 | 77359 | 110411678 |
| Therapeutic product effect incomplete | 54.35 | 18.94 | 74 | 100188 | 223731 | 110265306 |
| Depression | 53.76 | 18.94 | 131 | 100131 | 317204 | 110171833 |
| Blood calcium increased | 52.57 | 18.94 | 73 | 100189 | 17967 | 110471070 |
| Loss of personal independence in daily activities | 52.21 | 18.94 | 36 | 100226 | 149984 | 110339053 |
| Monoclonal immunoglobulin present | 51.90 | 18.94 | 31 | 100231 | 2509 | 110486528 |
| Anaphylactic reaction | 50.76 | 18.94 | 20 | 100242 | 114280 | 110374757 |
| Pneumonia pneumococcal | 49.72 | 18.94 | 39 | 100223 | 4926 | 110484111 |
| Incorrect dose administered | 49.67 | 18.94 | 16 | 100246 | 103625 | 110385412 |
| Rib fracture | 49.00 | 18.94 | 100 | 100162 | 33670 | 110455367 |
| Lactic acidosis | 48.80 | 18.94 | 12 | 100250 | 92799 | 110396238 |
| Rash pruritic | 48.70 | 18.94 | 197 | 100065 | 97872 | 110391165 |
| Aspartate aminotransferase increased | 48.58 | 18.94 | 44 | 100218 | 159892 | 110329145 |
| Blood creatine phosphokinase increased | 48.35 | 18.94 | 5 | 100257 | 73072 | 110415965 |
| Pneumocystis jirovecii pneumonia | 47.80 | 18.94 | 114 | 100148 | 42621 | 110446416 |
| Upper respiratory tract infection | 47.37 | 18.94 | 240 | 100022 | 131088 | 110357949 |
| Inappropriate schedule of product administration | 46.80 | 18.94 | 70 | 100192 | 203567 | 110285470 |
| Osteoporosis | 46.35 | 18.94 | 11 | 100251 | 87141 | 110401896 |
| Stomatitis | 46.21 | 18.94 | 111 | 100151 | 270131 | 110218906 |
| Immune system disorder | 46.05 | 18.94 | 59 | 100203 | 13442 | 110475595 |
| Underdose | 45.77 | 18.94 | 3 | 100259 | 63551 | 110425486 |
| Parainfluenzae virus infection | 45.76 | 18.94 | 43 | 100219 | 6931 | 110482106 |
| Cataract | 45.47 | 18.94 | 167 | 100095 | 79318 | 110409719 |
| Keratopathy | 45.33 | 18.94 | 23 | 100239 | 1350 | 110487687 |
| Pneumonia influenzal | 44.98 | 18.94 | 33 | 100229 | 3772 | 110485265 |
| Coronavirus infection | 44.62 | 18.94 | 49 | 100213 | 9496 | 110479541 |
| Neutrophil count abnormal | 44.38 | 18.94 | 37 | 100225 | 5095 | 110483942 |
| Peripheral sensory neuropathy | 43.47 | 18.94 | 64 | 100198 | 16616 | 110472421 |
| Pneumonia parainfluenzae viral | 43.33 | 18.94 | 18 | 100244 | 663 | 110488374 |
| Sedation | 43.07 | 18.94 | 6 | 100256 | 69677 | 110419360 |
| Hepatitis | 42.98 | 18.94 | 14 | 100248 | 90040 | 110398997 |
| Angioedema | 42.50 | 18.94 | 18 | 100244 | 98482 | 110390555 |
| Full blood count increased | 41.65 | 18.94 | 18 | 100244 | 732 | 110488305 |
| Hypoglycaemia | 41.56 | 18.94 | 27 | 100235 | 116077 | 110372960 |
| Crystal nephropathy | 41.47 | 18.94 | 24 | 100238 | 1832 | 110487205 |
| Hypersensitivity | 41.27 | 18.94 | 207 | 100055 | 403791 | 110085246 |
| Blood pressure systolic increased | 41.23 | 18.94 | 12 | 100250 | 82979 | 110406058 |
| Full blood count abnormal | 41.09 | 18.94 | 128 | 100134 | 55924 | 110433113 |
| Suicidal ideation | 40.80 | 18.94 | 17 | 100245 | 93920 | 110395117 |
| Urticaria | 40.11 | 18.94 | 151 | 100111 | 318706 | 110170331 |
| Pallor | 39.69 | 18.94 | 3 | 100259 | 56464 | 110432573 |
| Weight decreased | 39.62 | 18.94 | 255 | 100007 | 467802 | 110021235 |
| Lymphocyte count decreased | 39.48 | 18.94 | 128 | 100134 | 57115 | 110431922 |
| Hip arthroplasty | 39.14 | 18.94 | 3 | 100259 | 55810 | 110433227 |
| C-reactive protein increased | 38.46 | 18.94 | 88 | 100174 | 217831 | 110271206 |
| Blepharospasm | 38.32 | 18.94 | 3 | 100259 | 54848 | 110434189 |
| Cellulitis enterococcal | 38.14 | 18.94 | 9 | 100253 | 44 | 110488993 |
| Sciatica | 38.11 | 18.94 | 18 | 100244 | 92381 | 110396656 |
| Respiratory tract infection viral | 38.11 | 18.94 | 36 | 100226 | 5842 | 110483195 |
| Myelosuppression | 38.03 | 18.94 | 178 | 100084 | 94162 | 110394875 |
| Localised infection | 37.97 | 18.94 | 105 | 100157 | 42943 | 110446094 |
| Alanine aminotransferase increased | 37.72 | 18.94 | 68 | 100194 | 183705 | 110305332 |
| JC virus infection | 37.39 | 18.94 | 34 | 100228 | 5256 | 110483781 |
| Hospice care | 37.14 | 18.94 | 51 | 100211 | 12422 | 110476615 |
| Drug ineffective for unapproved indication | 36.69 | 18.94 | 24 | 100238 | 102814 | 110386223 |
| Toxicity to various agents | 36.63 | 18.94 | 270 | 99992 | 480285 | 110008752 |
| Tumour lysis syndrome | 36.45 | 18.94 | 84 | 100178 | 30717 | 110458320 |
| Alopecia | 36.06 | 18.94 | 189 | 100073 | 364564 | 110124473 |
| Oxygen saturation decreased | 36.03 | 18.94 | 54 | 100208 | 156928 | 110332109 |
| Pancreatitis | 35.93 | 18.94 | 20 | 100242 | 93513 | 110395524 |
| Bone marrow disorder | 35.59 | 18.94 | 30 | 100232 | 4193 | 110484844 |
| Abdominal pain upper | 35.58 | 18.94 | 179 | 100083 | 348932 | 110140105 |
| Drug reaction with eosinophilia and systemic symptoms | 35.42 | 18.94 | 15 | 100247 | 82080 | 110406957 |
| Dehydration | 35.19 | 18.94 | 398 | 99864 | 279113 | 110209924 |
| Rectal haemorrhage | 35.17 | 18.94 | 34 | 100228 | 119799 | 110369238 |
| Monoclonal immunoglobulin increased | 34.80 | 18.94 | 15 | 100247 | 606 | 110488431 |
| Electrocardiogram QT prolonged | 34.27 | 18.94 | 29 | 100233 | 108931 | 110380106 |
| Frequent bowel movements | 34.24 | 18.94 | 11 | 100251 | 71379 | 110417658 |
| Spinal cord compression | 33.98 | 18.94 | 38 | 100224 | 7514 | 110481523 |
| Liver disorder | 33.55 | 18.94 | 48 | 100214 | 142195 | 110346842 |
| Joint stiffness | 32.90 | 18.94 | 10 | 100252 | 67233 | 110421804 |
| Injection site bruising | 32.67 | 18.94 | 4 | 100258 | 51259 | 110437778 |
| Listeriosis | 32.35 | 18.94 | 24 | 100238 | 2790 | 110486247 |
| Rhinovirus infection | 31.83 | 18.94 | 46 | 100216 | 11743 | 110477294 |
| Viral infection | 31.53 | 18.94 | 113 | 100149 | 53026 | 110436011 |
| Sleep disorder due to a general medical condition | 31.03 | 18.94 | 5 | 100257 | 52107 | 110436930 |
| Drug ineffective | 30.88 | 18.94 | 1099 | 99163 | 1519441 | 108969596 |
| Product dispensing issue | 30.86 | 18.94 | 14 | 100248 | 640 | 110488397 |
| Blood pressure increased | 30.80 | 18.94 | 125 | 100137 | 258248 | 110230789 |
| Blood test abnormal | 30.68 | 18.94 | 75 | 100187 | 28479 | 110460558 |
| SARS-CoV-2 test positive | 30.54 | 18.94 | 55 | 100207 | 16880 | 110472157 |
| Diverticulitis | 30.23 | 18.94 | 112 | 100150 | 53410 | 110435627 |
| Ascites | 30.05 | 18.94 | 24 | 100238 | 92784 | 110396253 |
| IgA nephropathy | 29.79 | 18.94 | 24 | 100238 | 3149 | 110485888 |
| Drug level increased | 29.75 | 18.94 | 4 | 100258 | 47715 | 110441322 |
| Atrial flutter | 29.63 | 18.94 | 67 | 100195 | 24195 | 110464842 |
| Gastrointestinal disorder | 29.51 | 18.94 | 116 | 100146 | 241836 | 110247201 |
| Nail disorder | 29.48 | 18.94 | 8 | 100254 | 57927 | 110431110 |
| Gastrooesophageal reflux disease | 29.14 | 18.94 | 76 | 100186 | 179900 | 110309137 |
| Injection site swelling | 28.80 | 18.94 | 10 | 100252 | 61780 | 110427257 |
| Blood pressure fluctuation | 28.74 | 18.94 | 16 | 100246 | 74808 | 110414229 |
| Road traffic accident | 28.68 | 18.94 | 33 | 100229 | 107365 | 110381672 |
| Bacterial sepsis | 28.62 | 18.94 | 41 | 100221 | 10385 | 110478652 |
| Haematemesis | 28.54 | 18.94 | 9 | 100253 | 59099 | 110429938 |
| Onychomadesis | 28.06 | 18.94 | 4 | 100258 | 45659 | 110443378 |
| Cardiac failure congestive | 27.85 | 18.94 | 233 | 100029 | 150767 | 110338270 |
| Lymphodepletion | 27.54 | 18.94 | 7 | 100255 | 49 | 110488988 |
| Melaena | 27.44 | 18.94 | 14 | 100248 | 68743 | 110420294 |
| International normalised ratio increased | 27.40 | 18.94 | 23 | 100239 | 86749 | 110402288 |
| Hyperkalaemia | 27.20 | 18.94 | 51 | 100211 | 135745 | 110353292 |
| Spinal fracture | 27.09 | 18.94 | 62 | 100200 | 22571 | 110466466 |
| Light chain analysis decreased | 27.04 | 18.94 | 6 | 100256 | 21 | 110489016 |
| Chest discomfort | 26.95 | 18.94 | 75 | 100187 | 173773 | 110315264 |
| Back disorder | 26.93 | 18.94 | 59 | 100203 | 20863 | 110468174 |
| Toxic epidermal necrolysis | 26.75 | 18.94 | 9 | 100253 | 56718 | 110432319 |
| Feeling hot | 26.56 | 18.94 | 26 | 100236 | 91080 | 110397957 |
| Disease progression | 26.55 | 18.94 | 338 | 99924 | 243696 | 110245341 |
| Joint swelling | 26.49 | 18.94 | 265 | 99997 | 442580 | 110046457 |
| Dyskinesia | 26.37 | 18.94 | 7 | 100255 | 51439 | 110437598 |
| Metabolic acidosis | 26.26 | 18.94 | 31 | 100231 | 99713 | 110389324 |
| Hypothyroidism | 26.02 | 18.94 | 17 | 100245 | 72882 | 110416155 |
| Foot deformity | 26.01 | 18.94 | 6 | 100256 | 48474 | 110440563 |
| Vision blurred | 25.92 | 18.94 | 203 | 100059 | 128819 | 110360218 |
| Bacteraemia | 25.89 | 18.94 | 91 | 100171 | 42299 | 110446738 |
| Plasma cells increased | 25.86 | 18.94 | 8 | 100254 | 122 | 110488915 |
| Cellulitis | 25.72 | 18.94 | 199 | 100063 | 125817 | 110363220 |
| General physical health deterioration | 25.64 | 18.94 | 254 | 100008 | 425041 | 110063996 |
| Eczema | 25.61 | 18.94 | 17 | 100245 | 72276 | 110416761 |
| Hallucination, visual | 25.47 | 18.94 | 3 | 100259 | 39602 | 110449435 |
| Septic shock | 25.40 | 18.94 | 236 | 100026 | 157292 | 110331745 |
| Haematochezia | 25.30 | 18.94 | 41 | 100221 | 115483 | 110373554 |
| Accidental exposure to product | 25.27 | 18.94 | 7 | 100255 | 50001 | 110439036 |
| Generalised tonic-clonic seizure | 25.23 | 18.94 | 9 | 100253 | 54671 | 110434366 |
| Natural killer cell count decreased | 25.11 | 18.94 | 8 | 100254 | 135 | 110488902 |
| Femur fracture | 25.06 | 18.94 | 93 | 100169 | 44376 | 110444661 |
| Accidental overdose | 24.84 | 18.94 | 8 | 100254 | 51826 | 110437211 |
| Humerus fracture | 24.76 | 18.94 | 39 | 100223 | 10737 | 110478300 |
| Compression fracture | 24.69 | 18.94 | 36 | 100226 | 9263 | 110479774 |
| Blood disorder | 24.64 | 18.94 | 37 | 100225 | 9773 | 110479264 |
| Myelodysplastic syndrome | 24.22 | 18.94 | 82 | 100180 | 37402 | 110451635 |
| Blood bilirubin increased | 24.16 | 18.94 | 20 | 100242 | 75952 | 110413085 |
| Musculoskeletal chest pain | 24.10 | 18.94 | 69 | 100193 | 28778 | 110460259 |
| Clavicle fracture | 24.07 | 18.94 | 27 | 100235 | 5357 | 110483680 |
| Arthritis | 24.02 | 18.94 | 75 | 100187 | 167511 | 110321526 |
| Hypokalaemia | 23.85 | 18.94 | 85 | 100177 | 182363 | 110306674 |
| Hepatic cirrhosis | 23.83 | 18.94 | 16 | 100246 | 67610 | 110421427 |
| Dry mouth | 23.66 | 18.94 | 97 | 100165 | 199851 | 110289186 |
| Cardiac failure | 23.52 | 18.94 | 267 | 99995 | 187359 | 110301678 |
| Depressed mood | 23.36 | 18.94 | 13 | 100249 | 60796 | 110428241 |
| Clostridium difficile infection | 22.98 | 18.94 | 101 | 100161 | 52028 | 110437009 |
| Leukocytosis | 22.96 | 18.94 | 10 | 100252 | 53818 | 110435219 |
| Anaphylactic shock | 22.92 | 18.94 | 9 | 100253 | 51537 | 110437500 |
| Eosinophilia | 22.82 | 18.94 | 12 | 100250 | 57924 | 110431113 |
| Gait inability | 22.53 | 18.94 | 57 | 100205 | 136319 | 110352718 |
| Hemiparesis | 22.46 | 18.94 | 6 | 100256 | 43897 | 110445140 |
| Swelling face | 22.41 | 18.94 | 152 | 100110 | 92169 | 110396868 |
| Fracture | 22.39 | 18.94 | 61 | 100201 | 24727 | 110464310 |
| Dyspepsia | 22.37 | 18.94 | 93 | 100169 | 190872 | 110298165 |
| Surgery | 22.37 | 18.94 | 5 | 100257 | 41278 | 110447759 |
| Hyperlipidaemia | 22.36 | 18.94 | 3 | 100259 | 35845 | 110453192 |
| Wound infection | 22.31 | 18.94 | 33 | 100229 | 96432 | 110392605 |
| Dysarthria | 22.30 | 18.94 | 26 | 100236 | 84095 | 110404942 |
| Bile acid malabsorption | 21.90 | 18.94 | 10 | 100252 | 464 | 110488573 |
| Peritonitis viral | 21.89 | 18.94 | 6 | 100256 | 58 | 110488979 |
| Pulmonary oedema | 21.68 | 18.94 | 161 | 100101 | 100498 | 110388539 |
| Restlessness | 21.65 | 18.94 | 12 | 100250 | 56247 | 110432790 |
| Upper limb fracture | 21.53 | 18.94 | 54 | 100208 | 20834 | 110468203 |
| Swelling | 21.43 | 18.94 | 209 | 100053 | 350832 | 110138205 |
| Hypotension | 21.39 | 18.94 | 340 | 99922 | 523509 | 109965528 |
| Neutrophil count increased | 21.37 | 18.94 | 3 | 100259 | 34649 | 110454388 |
| Therapy change | 21.36 | 18.94 | 35 | 100227 | 9962 | 110479075 |
| Bradycardia | 21.31 | 18.94 | 71 | 100191 | 155446 | 110333591 |
| Light chain analysis abnormal | 21.19 | 18.94 | 8 | 100254 | 228 | 110488809 |
| Seizure | 21.07 | 18.94 | 116 | 100146 | 221069 | 110267968 |
| Gastrointestinal infection | 20.95 | 18.94 | 42 | 100220 | 13963 | 110475074 |
| Lung disorder | 20.89 | 18.94 | 88 | 100174 | 179959 | 110309078 |
| Device related sepsis | 20.88 | 18.94 | 30 | 100232 | 7617 | 110481420 |
| Aggression | 20.87 | 18.94 | 14 | 100248 | 59196 | 110429841 |
| Middle ear inflammation | 20.64 | 18.94 | 8 | 100254 | 245 | 110488792 |
| Obstructive airways disorder | 20.61 | 18.94 | 8 | 100254 | 46141 | 110442896 |
| Therapy partial responder | 20.46 | 18.94 | 77 | 100185 | 36984 | 110452053 |
| Tooth infection | 20.40 | 18.94 | 55 | 100207 | 22161 | 110466876 |
| Vasculitis | 20.14 | 18.94 | 4 | 100258 | 35869 | 110453168 |
| Skin ulcer | 19.94 | 18.94 | 17 | 100245 | 63628 | 110425409 |
| Metapneumovirus infection | 19.86 | 18.94 | 17 | 100245 | 2427 | 110486610 |
| Masked fever | 19.79 | 18.94 | 5 | 100257 | 34 | 110489003 |
| Ear swelling | 19.73 | 18.94 | 16 | 100246 | 2120 | 110486917 |
| Jugular vein occlusion | 19.67 | 18.94 | 6 | 100256 | 87 | 110488950 |
| Cholestasis | 19.29 | 18.94 | 18 | 100244 | 64500 | 110424537 |
| Night sweats | 19.17 | 18.94 | 60 | 100202 | 133923 | 110355114 |
| Device issue | 19.08 | 18.94 | 4 | 100258 | 34531 | 110454506 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | L04AX06 | ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS IMMUNOSUPPRESSANTS IMMUNOSUPPRESSANTS Other immunosuppressants |
| MeSH PA | D000970 | Antineoplastic Agents |
| MeSH PA | D006131 | Growth Inhibitors |
| MeSH PA | D006133 | Growth Substances |
| MeSH PA | D007155 | Immunologic Factors |
| MeSH PA | D020533 | Angiogenesis Inhibitors |
| FDA EPC | N0000184014 | Thalidomide Analog |
| CHEBI has role | CHEBI:35610 | antineoplastic agent |
| CHEBI has role | CHEBI:48422 | angiogenesis inhibitor |
| CHEBI has role | CHEBI:50846 | immunomodulator |
| CHEBI has role | CHEBI:75835 | anti-anaemic agent |
| CHEBI has role | CHEBI:233423 | antifibrotic agent |
Related Drugs by ATC class:
L04AX Other immunosuppressants 8 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Multiple myeloma | indication | 109989006 | DOID:9538 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 7.84 | acidic |
| pKa2 | 1.86 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
| Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Exclusivity date | Description |
|---|---|---|---|---|---|---|---|---|---|
| 1MG | POMALIDOMIDE | BRECKENRIDGE | A210111 | Oct. 30, 2020 | RX | CAPSULE | ORAL | Aug. 29, 2026 | PATENT CHALLENGE |
| 2MG | POMALIDOMIDE | BRECKENRIDGE | A210111 | Oct. 30, 2020 | RX | CAPSULE | ORAL | Aug. 29, 2026 | PATENT CHALLENGE |
| 3MG | POMALIDOMIDE | BRECKENRIDGE | A210111 | Oct. 30, 2020 | RX | CAPSULE | ORAL | Aug. 29, 2026 | PATENT CHALLENGE |
| 4MG | POMALIDOMIDE | BRECKENRIDGE | A210111 | Oct. 30, 2020 | RX | CAPSULE | ORAL | Aug. 29, 2026 | PATENT CHALLENGE |
| 1MG | POMALYST | BRISTOL | N204026 | Feb. 8, 2013 | RX | CAPSULE | ORAL | May 14, 2027 | FOR THE TREATMENT OF KAPOSI SARCOMA (KS) IN ADULT PATIENTS WHO ARE HIV-NEGATIVE |
| 1MG | POMALYST | BRISTOL | N204026 | Feb. 8, 2013 | RX | CAPSULE | ORAL | May 14, 2027 | INDICATED FOR THE TREATMENT OF ADULT PATIENTS WITH AIDS-RELATED KAPOSI SARCOMA (KS) AFTER FAILURE OF HIGHLY ACTIVE ANTIRETROVIRAL THERAPY (HAART) |
| 2MG | POMALYST | BRISTOL | N204026 | Feb. 8, 2013 | RX | CAPSULE | ORAL | May 14, 2027 | FOR THE TREATMENT OF KAPOSI SARCOMA (KS) IN ADULT PATIENTS WHO ARE HIV-NEGATIVE |
| 2MG | POMALYST | BRISTOL | N204026 | Feb. 8, 2013 | RX | CAPSULE | ORAL | May 14, 2027 | INDICATED FOR THE TREATMENT OF ADULT PATIENTS WITH AIDS-RELATED KAPOSI SARCOMA (KS) AFTER FAILURE OF HIGHLY ACTIVE ANTIRETROVIRAL THERAPY (HAART) |
| 3MG | POMALYST | BRISTOL | N204026 | Feb. 8, 2013 | RX | CAPSULE | ORAL | May 14, 2027 | FOR THE TREATMENT OF KAPOSI SARCOMA (KS) IN ADULT PATIENTS WHO ARE HIV-NEGATIVE |
| 3MG | POMALYST | BRISTOL | N204026 | Feb. 8, 2013 | RX | CAPSULE | ORAL | May 14, 2027 | INDICATED FOR THE TREATMENT OF ADULT PATIENTS WITH AIDS-RELATED KAPOSI SARCOMA (KS) AFTER FAILURE OF HIGHLY ACTIVE ANTIRETROVIRAL THERAPY (HAART) |
| 4MG | POMALYST | BRISTOL | N204026 | Feb. 8, 2013 | RX | CAPSULE | ORAL | May 14, 2027 | FOR THE TREATMENT OF KAPOSI SARCOMA (KS) IN ADULT PATIENTS WHO ARE HIV-NEGATIVE |
| 4MG | POMALYST | BRISTOL | N204026 | Feb. 8, 2013 | RX | CAPSULE | ORAL | May 14, 2027 | INDICATED FOR THE TREATMENT OF ADULT PATIENTS WITH AIDS-RELATED KAPOSI SARCOMA (KS) AFTER FAILURE OF HIGHLY ACTIVE ANTIRETROVIRAL THERAPY (HAART) |
| 1MG | POMALYST | BRISTOL | N204026 | Feb. 8, 2013 | RX | CAPSULE | ORAL | Nov. 14, 2027 | PEDIATRIC EXCLUSIVITY |
| 2MG | POMALYST | BRISTOL | N204026 | Feb. 8, 2013 | RX | CAPSULE | ORAL | Nov. 14, 2027 | PEDIATRIC EXCLUSIVITY |
| 3MG | POMALYST | BRISTOL | N204026 | Feb. 8, 2013 | RX | CAPSULE | ORAL | Nov. 14, 2027 | PEDIATRIC EXCLUSIVITY |
| 4MG | POMALYST | BRISTOL | N204026 | Feb. 8, 2013 | RX | CAPSULE | ORAL | Nov. 14, 2027 | PEDIATRIC EXCLUSIVITY |
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Protein cereblon | Cytosolic other | MODULATOR | EC50 | 6.58 | SCIENTIFIC LITERATURE | SCIENTIFIC LITERATURE | |||
| Tumor necrosis factor | Cytokine | IC50 | 7.48 | CHEMBL | |||||
| Interleukin-1 beta | Cytokine | IC50 | 7.33 | CHEMBL | |||||
| Cereblon isoform 4 | Cytosolic other | Ki | 6.10 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D08976 | KEGG_DRUG |
| 4032092 | VANDF |
| CHEBI:72690 | CHEBI |
| CHEMBL43452 | ChEMBL_ID |
| C467566 | MESH_SUPPLEMENTAL_RECORD_UI |
| 7348 | IUPHAR_LIGAND_ID |
| DB08910 | DRUGBANK_ID |
| D2UX06XLB5 | UNII |
| 1369713 | RXNORM |
| 199372 | MMSL |
| 29234 | MMSL |
| 389764 | MMSL |
| d08041 | MMSL |
| 014897 | NDDF |
| 703789000 | SNOMEDCT_US |
| 703790009 | SNOMEDCT_US |
| C2347624 | UMLSCUI |
| 8873 | INN_ID |
| 134780 | PUBCHEM_CID |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Pomalidomide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0480-2601 | CAPSULE | 3 mg | ORAL | ANDA | 30 sections |
| Pomalidomide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0480-4018 | CAPSULE | 1 mg | ORAL | ANDA | 30 sections |
| Pomalidomide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0480-4022 | CAPSULE | 2 mg | ORAL | ANDA | 30 sections |
| Pomalidomide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0480-4035 | CAPSULE | 4 mg | ORAL | ANDA | 30 sections |
| Pomalidomide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 31722-770 | CAPSULE | 1 mg | ORAL | ANDA | 30 sections |
| Pomalidomide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 31722-771 | CAPSULE | 2 mg | ORAL | ANDA | 30 sections |
| Pomalidomide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 31722-772 | CAPSULE | 3 mg | ORAL | ANDA | 30 sections |
| Pomalidomide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 31722-773 | CAPSULE | 4 mg | ORAL | ANDA | 30 sections |
| Pomalidomide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51991-342 | CAPSULE | 1 mg | ORAL | ANDA | 35 sections |
| Pomalidomide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51991-343 | CAPSULE | 2 mg | ORAL | ANDA | 35 sections |
| Pomalidomide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51991-344 | CAPSULE | 3 mg | ORAL | ANDA | 35 sections |
| Pomalidomide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51991-346 | CAPSULE | 4 mg | ORAL | ANDA | 35 sections |
| Pomalyst | HUMAN PRESCRIPTION DRUG LABEL | 1 | 59572-501 | CAPSULE | 1 mg | ORAL | NDA | 33 sections |
| Pomalyst | HUMAN PRESCRIPTION DRUG LABEL | 1 | 59572-502 | CAPSULE | 2 mg | ORAL | NDA | 33 sections |
| Pomalyst | HUMAN PRESCRIPTION DRUG LABEL | 1 | 59572-503 | CAPSULE | 3 mg | ORAL | NDA | 33 sections |
| Pomalyst | HUMAN PRESCRIPTION DRUG LABEL | 1 | 59572-504 | CAPSULE | 4 mg | ORAL | NDA | 33 sections |
| Pomalidomide | Human Prescription Drug Label | 1 | 59651-194 | CAPSULE | 1 mg | ORAL | ANDA | 30 sections |
| Pomalidomide | Human Prescription Drug Label | 1 | 59651-195 | CAPSULE | 2 mg | ORAL | ANDA | 30 sections |
| Pomalidomide | Human Prescription Drug Label | 1 | 59651-196 | CAPSULE | 3 mg | ORAL | ANDA | 30 sections |
| Pomalidomide | Human Prescription Drug Label | 1 | 59651-197 | CAPSULE | 4 mg | ORAL | ANDA | 30 sections |
| Pomalidomide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 60505-4497 | CAPSULE | 1 mg | ORAL | ANDA | 31 sections |
| Pomalidomide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 60505-4498 | CAPSULE | 2 mg | ORAL | ANDA | 31 sections |
| Pomalidomide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 60505-4499 | CAPSULE | 3 mg | ORAL | ANDA | 31 sections |
| Pomalidomide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 60505-4500 | CAPSULE | 4 mg | ORAL | ANDA | 31 sections |
| Pomalidomide | Human Prescription Drug Label | 1 | 63850-0131 | CAPSULE | 1 mg | ORAL | ANDA | 29 sections |
| Pomalidomide | Human Prescription Drug Label | 1 | 63850-0132 | CAPSULE | 2 mg | ORAL | ANDA | 29 sections |
| Pomalidomide | Human Prescription Drug Label | 1 | 63850-0133 | CAPSULE | 3 mg | ORAL | ANDA | 29 sections |
| Pomalidomide | Human Prescription Drug Label | 1 | 63850-0134 | CAPSULE | 4 mg | ORAL | ANDA | 29 sections |