Stem definition | Drug id | CAS RN |
---|---|---|
3317 | 191732-72-6 |
Dose | Unit | Route |
---|---|---|
10 | mg | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 4 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 0.00 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 66 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 1.38 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
Date | Agency | Company | Orphan |
---|---|---|---|
June 14, 2007 | EMA | CELEGENE EUROPE BV | |
Dec. 27, 2005 | FDA | CELGENE |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Plasma cell myeloma | 12211.04 | 14.30 | 5425 | 226861 | 39053 | 46414723 |
Full blood count decreased | 5121.66 | 14.30 | 2404 | 229882 | 19807 | 46433969 |
Death | 4091.65 | 14.30 | 6526 | 225760 | 329022 | 46124754 |
Diarrhoea | 3085.05 | 14.30 | 7810 | 224476 | 551792 | 45901984 |
White blood cell count decreased | 2844.87 | 14.30 | 3134 | 229152 | 109097 | 46344679 |
Thrombosis | 2605.33 | 14.30 | 2188 | 230098 | 53881 | 46399895 |
Neuropathy peripheral | 2491.07 | 14.30 | 2646 | 229640 | 88247 | 46365529 |
Pneumonia | 2265.53 | 14.30 | 5443 | 226843 | 370877 | 46082899 |
Laboratory test abnormal | 2100.13 | 14.30 | 1347 | 230939 | 21500 | 46432276 |
Platelet count decreased | 2020.56 | 14.30 | 2487 | 229799 | 97537 | 46356239 |
Adverse drug reaction | 1415.53 | 14.30 | 1403 | 230883 | 42959 | 46410817 |
Unevaluable event | 1341.17 | 14.30 | 1388 | 230898 | 44787 | 46408989 |
Fatigue | 1062.84 | 14.30 | 5873 | 226413 | 602824 | 45850952 |
Drug ineffective | 1046.90 | 14.30 | 1104 | 231182 | 676734 | 45777042 |
Rheumatoid arthritis | 1039.52 | 14.30 | 35 | 232251 | 240180 | 46213596 |
Off label use | 1017.68 | 14.30 | 314 | 231972 | 379527 | 46074249 |
Rash | 978.66 | 14.30 | 3928 | 228358 | 352584 | 46101192 |
Human chorionic gonadotropin increased | 925.62 | 14.30 | 313 | 231973 | 914 | 46452862 |
Plasma cell myeloma recurrent | 783.18 | 14.30 | 332 | 231954 | 2075 | 46451701 |
Condition aggravated | 761.63 | 14.30 | 148 | 232138 | 244904 | 46208872 |
Neutropenia | 745.33 | 14.30 | 1966 | 230320 | 141238 | 46312538 |
Constipation | 739.49 | 14.30 | 2220 | 230066 | 171877 | 46281899 |
Muscle spasms | 731.08 | 14.30 | 1777 | 230509 | 121336 | 46332440 |
Myelodysplastic syndrome | 720.01 | 14.30 | 609 | 231677 | 15102 | 46438674 |
Drug interaction | 719.41 | 14.30 | 84 | 232202 | 203010 | 46250766 |
Completed suicide | 683.07 | 14.30 | 8 | 232278 | 145912 | 46307864 |
Deep vein thrombosis | 679.49 | 14.30 | 1332 | 230954 | 78441 | 46375335 |
Pancytopenia | 643.39 | 14.30 | 1352 | 230934 | 83706 | 46370070 |
Haemoglobin decreased | 602.52 | 14.30 | 1702 | 230584 | 127247 | 46326529 |
Blood potassium decreased | 594.14 | 14.30 | 835 | 231451 | 37228 | 46416548 |
Product dose omission issue | 574.80 | 14.30 | 1994 | 230292 | 166526 | 46287250 |
Neutrophil count decreased | 567.22 | 14.30 | 876 | 231410 | 42550 | 46411226 |
Drug hypersensitivity | 487.45 | 14.30 | 306 | 231980 | 243519 | 46210257 |
Maternal exposure during pregnancy | 487.39 | 14.30 | 4 | 232282 | 102545 | 46351231 |
Ageusia | 481.61 | 14.30 | 423 | 231863 | 11049 | 46442727 |
Exposure during pregnancy | 463.25 | 14.30 | 17 | 232269 | 108195 | 46345581 |
Injection site pain | 461.61 | 14.30 | 16 | 232270 | 107136 | 46346640 |
Red blood cell count decreased | 449.87 | 14.30 | 675 | 231611 | 31948 | 46421828 |
Renal disorder | 447.30 | 14.30 | 606 | 231680 | 26080 | 46427696 |
Tooth disorder | 446.18 | 14.30 | 565 | 231721 | 22738 | 46431038 |
Skin discolouration | 444.71 | 14.30 | 672 | 231614 | 32008 | 46421768 |
Headache | 424.58 | 14.30 | 1113 | 231173 | 477239 | 45976537 |
Plasmacytoma | 400.71 | 14.30 | 211 | 232075 | 2266 | 46451510 |
Thrombocytopenia | 395.47 | 14.30 | 1456 | 230830 | 125125 | 46328651 |
Multiple allergies | 394.95 | 14.30 | 313 | 231973 | 7058 | 46446718 |
Cytopenia | 382.60 | 14.30 | 314 | 231972 | 7454 | 46446322 |
COVID-19 | 382.26 | 14.30 | 467 | 231819 | 18108 | 46435668 |
Pulmonary thrombosis | 381.00 | 14.30 | 307 | 231979 | 7095 | 46446681 |
Asthenia | 358.11 | 14.30 | 2709 | 229577 | 308366 | 46145410 |
Overdose | 353.84 | 14.30 | 45 | 232241 | 101934 | 46351842 |
Arthralgia | 340.35 | 14.30 | 826 | 231460 | 363777 | 46089999 |
Peripheral swelling | 334.27 | 14.30 | 1614 | 230672 | 156457 | 46297319 |
Seasonal allergy | 334.17 | 14.30 | 371 | 231915 | 12963 | 46440813 |
Cardiac disorder | 327.66 | 14.30 | 694 | 231592 | 43164 | 46410612 |
Dehydration | 299.29 | 14.30 | 1575 | 230711 | 157965 | 46295811 |
Hip fracture | 297.84 | 14.30 | 500 | 231786 | 26056 | 46427720 |
Rash pruritic | 296.60 | 14.30 | 670 | 231616 | 43545 | 46410231 |
Product use issue | 281.53 | 14.30 | 63 | 232223 | 94581 | 46359195 |
Taste disorder | 279.88 | 14.30 | 233 | 232053 | 5645 | 46448131 |
Synovitis | 278.54 | 14.30 | 5 | 232281 | 61070 | 46392706 |
Acute myeloid leukaemia | 277.68 | 14.30 | 367 | 231919 | 15411 | 46438365 |
Blood test abnormal | 275.74 | 14.30 | 286 | 232000 | 9234 | 46444542 |
Therapeutic product effect incomplete | 272.27 | 14.30 | 34 | 232252 | 78119 | 46375657 |
Injection site erythema | 270.26 | 14.30 | 28 | 232258 | 74399 | 46379377 |
Full blood count increased | 268.53 | 14.30 | 117 | 232169 | 789 | 46452987 |
Psoriasis | 262.45 | 14.30 | 39 | 232247 | 78565 | 46375211 |
Systemic lupus erythematosus | 260.36 | 14.30 | 16 | 232270 | 65164 | 46388612 |
Cataract | 258.92 | 14.30 | 646 | 231640 | 44769 | 46409007 |
Plasma cell leukaemia | 249.76 | 14.30 | 121 | 232165 | 1072 | 46452704 |
Pain | 246.56 | 14.30 | 1381 | 230905 | 475567 | 45978209 |
Blood count abnormal | 246.52 | 14.30 | 370 | 231916 | 17508 | 46436268 |
Monoclonal immunoglobulin present | 239.18 | 14.30 | 102 | 232184 | 648 | 46453128 |
Suicide attempt | 237.72 | 14.30 | 8 | 232278 | 55028 | 46398748 |
Dry skin | 237.58 | 14.30 | 587 | 231699 | 40429 | 46413347 |
Renal failure | 233.56 | 14.30 | 1151 | 231135 | 112443 | 46341333 |
Product use in unapproved indication | 231.42 | 14.30 | 80 | 232206 | 90193 | 46363583 |
Hospitalisation | 229.74 | 14.30 | 24 | 232262 | 63361 | 46390415 |
Adult T-cell lymphoma/leukaemia | 225.91 | 14.30 | 79 | 232207 | 263 | 46453513 |
Anaemia | 224.39 | 14.30 | 2097 | 230189 | 253682 | 46200094 |
Protein total increased | 223.96 | 14.30 | 145 | 232141 | 2348 | 46451428 |
Infusion related reaction | 223.53 | 14.30 | 112 | 232174 | 101096 | 46352680 |
Spinal fracture | 222.90 | 14.30 | 325 | 231961 | 14980 | 46438796 |
Treatment failure | 219.54 | 14.30 | 94 | 232192 | 92993 | 46360783 |
Alanine aminotransferase increased | 217.24 | 14.30 | 84 | 232202 | 88367 | 46365409 |
Body height decreased | 208.91 | 14.30 | 249 | 232037 | 9403 | 46444373 |
Aspartate aminotransferase increased | 208.29 | 14.30 | 66 | 232220 | 78634 | 46375142 |
Wrong technique in product usage process | 206.86 | 14.30 | 17 | 232269 | 54405 | 46399371 |
Intentional product misuse | 206.60 | 14.30 | 6 | 232280 | 47122 | 46406654 |
Abortion spontaneous | 201.41 | 14.30 | 3 | 232283 | 43643 | 46410133 |
Intentional product use issue | 199.20 | 14.30 | 17 | 232269 | 52763 | 46401013 |
Tachycardia | 198.77 | 14.30 | 125 | 232161 | 99497 | 46354279 |
Light chain analysis increased | 195.02 | 14.30 | 99 | 232187 | 979 | 46452797 |
Influenza | 188.77 | 14.30 | 912 | 231374 | 88358 | 46365418 |
Suicidal ideation | 188.14 | 14.30 | 28 | 232258 | 56354 | 46397422 |
Injection site reaction | 184.51 | 14.30 | 14 | 232272 | 47835 | 46405941 |
Hyponatraemia | 183.80 | 14.30 | 141 | 232145 | 101191 | 46352585 |
Depression | 180.84 | 14.30 | 358 | 231928 | 169746 | 46284030 |
Gastric disorder | 179.41 | 14.30 | 405 | 231881 | 26300 | 46427476 |
Urinary tract infection | 178.31 | 14.30 | 1776 | 230510 | 218490 | 46235286 |
Anaphylactic reaction | 178.09 | 14.30 | 26 | 232260 | 53086 | 46400690 |
Oxygen saturation decreased | 177.76 | 14.30 | 61 | 232225 | 69103 | 46384673 |
Pulmonary embolism | 172.17 | 14.30 | 1025 | 231261 | 107560 | 46346216 |
Myelodysplastic syndrome transformation | 171.59 | 14.30 | 70 | 232216 | 391 | 46453385 |
Injection site pruritus | 170.85 | 14.30 | 6 | 232280 | 39737 | 46414039 |
Hypertension | 167.31 | 14.30 | 465 | 231821 | 195891 | 46257885 |
Sepsis | 166.99 | 14.30 | 1204 | 231082 | 134810 | 46318966 |
Pruritus | 164.88 | 14.30 | 1887 | 230399 | 240465 | 46213311 |
Therapeutic product effect decreased | 158.85 | 14.30 | 108 | 232178 | 82493 | 46371283 |
Migraine | 158.38 | 14.30 | 75 | 232211 | 69951 | 46383825 |
Injection site bruising | 158.21 | 14.30 | 4 | 232282 | 35632 | 46418144 |
Fall | 157.09 | 14.30 | 2402 | 229884 | 326695 | 46127081 |
Diffuse large B-cell lymphoma | 155.32 | 14.30 | 169 | 232117 | 5769 | 46448007 |
Injection site swelling | 154.92 | 14.30 | 12 | 232274 | 40315 | 46413461 |
Coma | 154.26 | 14.30 | 49 | 232237 | 58300 | 46395476 |
Inappropriate schedule of product administration | 144.94 | 14.30 | 71 | 232215 | 64942 | 46388834 |
Product quality issue | 144.64 | 14.30 | 8 | 232278 | 35640 | 46418136 |
Depressed level of consciousness | 142.76 | 14.30 | 31 | 232255 | 47538 | 46406238 |
Abdominal pain | 142.59 | 14.30 | 624 | 231662 | 229407 | 46224369 |
Back disorder | 140.26 | 14.30 | 199 | 232087 | 8942 | 46444834 |
Mobility decreased | 136.87 | 14.30 | 65 | 232221 | 60529 | 46393247 |
Hypoglycaemia | 136.12 | 14.30 | 50 | 232236 | 54299 | 46399477 |
Rhabdomyolysis | 134.89 | 14.30 | 23 | 232263 | 41886 | 46411890 |
Lactose intolerance | 134.88 | 14.30 | 105 | 232181 | 2304 | 46451472 |
SARS-CoV-2 test positive | 132.56 | 14.30 | 95 | 232191 | 1830 | 46451946 |
Bradycardia | 132.47 | 14.30 | 83 | 232203 | 66215 | 46387561 |
Sinus disorder | 131.72 | 14.30 | 269 | 232017 | 16294 | 46437482 |
Amyloidosis | 131.36 | 14.30 | 77 | 232209 | 1034 | 46452742 |
Squamous cell carcinoma of skin | 128.59 | 14.30 | 143 | 232143 | 5004 | 46448772 |
Agitation | 124.32 | 14.30 | 60 | 232226 | 55355 | 46398421 |
Anxiety | 121.79 | 14.30 | 479 | 231807 | 181478 | 46272298 |
Drug withdrawal syndrome | 118.17 | 14.30 | 4 | 232282 | 27380 | 46426396 |
Somnolence | 115.27 | 14.30 | 396 | 231890 | 156125 | 46297651 |
Lactic acidosis | 115.07 | 14.30 | 16 | 232270 | 33893 | 46419883 |
Pulmonary arterial hypertension | 114.76 | 14.30 | 3 | 232283 | 25925 | 46427851 |
Tumour flare | 113.64 | 14.30 | 46 | 232240 | 251 | 46453525 |
Atrial fibrillation | 112.98 | 14.30 | 892 | 231394 | 102698 | 46351078 |
Blood pressure increased | 112.30 | 14.30 | 294 | 231992 | 126372 | 46327404 |
Skin exfoliation | 112.12 | 14.30 | 390 | 231896 | 32548 | 46421228 |
Interstitial lung disease | 111.33 | 14.30 | 65 | 232221 | 53884 | 46399892 |
Upper limb fracture | 109.68 | 14.30 | 242 | 232044 | 15471 | 46438305 |
Blood creatine phosphokinase increased | 107.20 | 14.30 | 8 | 232278 | 27716 | 46426060 |
Electrocardiogram QT prolonged | 107.11 | 14.30 | 61 | 232225 | 51264 | 46402512 |
Loss of personal independence in daily activities | 106.97 | 14.30 | 77 | 232209 | 57106 | 46396670 |
Fibromyalgia | 106.93 | 14.30 | 25 | 232261 | 36438 | 46417338 |
Blood pressure systolic increased | 106.65 | 14.30 | 10 | 232276 | 28777 | 46424999 |
Vomiting | 106.62 | 14.30 | 1599 | 230687 | 451195 | 46002581 |
Drug intolerance | 106.20 | 14.30 | 1159 | 231127 | 145890 | 46307886 |
Decreased appetite | 105.81 | 14.30 | 1449 | 230837 | 192387 | 46261389 |
Clostridium difficile infection | 104.16 | 14.30 | 318 | 231968 | 24785 | 46428991 |
Immune system disorder | 103.90 | 14.30 | 161 | 232125 | 7834 | 46445942 |
Dysgeusia | 102.96 | 14.30 | 437 | 231849 | 40054 | 46413722 |
Hordeolum | 102.20 | 14.30 | 86 | 232200 | 2115 | 46451661 |
Hypoaesthesia | 101.65 | 14.30 | 970 | 231316 | 117899 | 46335877 |
Gamma-glutamyltransferase increased | 100.87 | 14.30 | 18 | 232268 | 31722 | 46422054 |
Emotional distress | 100.72 | 14.30 | 16 | 232270 | 30691 | 46423085 |
Osteoarthritis | 100.60 | 14.30 | 96 | 232190 | 61929 | 46391847 |
Mantle cell lymphoma | 100.32 | 14.30 | 52 | 232234 | 539 | 46453237 |
Seizure | 97.03 | 14.30 | 302 | 231984 | 122752 | 46331024 |
C-reactive protein increased | 97.01 | 14.30 | 89 | 232197 | 58501 | 46395275 |
Knee arthroplasty | 96.98 | 14.30 | 5 | 232281 | 23660 | 46430116 |
Disease progression | 95.63 | 14.30 | 779 | 231507 | 90521 | 46363255 |
Respiratory arrest | 95.63 | 14.30 | 25 | 232261 | 33791 | 46419985 |
Medication error | 95.10 | 14.30 | 19 | 232267 | 30892 | 46422884 |
Dementia | 94.28 | 14.30 | 221 | 232065 | 14709 | 46439067 |
Injury | 93.78 | 14.30 | 51 | 232235 | 43976 | 46409800 |
Chest discomfort | 93.26 | 14.30 | 193 | 232093 | 90076 | 46363700 |
Palpitations | 93.17 | 14.30 | 210 | 232076 | 95049 | 46358727 |
Erythema | 92.98 | 14.30 | 380 | 231906 | 142440 | 46311336 |
Surgery | 92.19 | 14.30 | 16 | 232270 | 28769 | 46425007 |
Hyperkalaemia | 91.35 | 14.30 | 71 | 232215 | 50638 | 46403138 |
Cardio-respiratory arrest | 89.91 | 14.30 | 99 | 232187 | 59770 | 46394006 |
Incorrect dose administered | 89.65 | 14.30 | 58 | 232228 | 45492 | 46408284 |
Multiple sclerosis | 88.25 | 14.30 | 10 | 232276 | 24781 | 46428995 |
Bone lesion | 87.21 | 14.30 | 115 | 232171 | 4816 | 46448960 |
Wheezing | 86.15 | 14.30 | 83 | 232203 | 53303 | 46400473 |
Injection site haemorrhage | 86.06 | 14.30 | 4 | 232282 | 20705 | 46433071 |
Nasopharyngitis | 83.90 | 14.30 | 1151 | 231135 | 152847 | 46300929 |
Cardiac amyloidosis | 83.75 | 14.30 | 44 | 232242 | 470 | 46453306 |
Ascites | 82.99 | 14.30 | 39 | 232247 | 36545 | 46417231 |
Blood alkaline phosphatase increased | 82.75 | 14.30 | 47 | 232239 | 39562 | 46414214 |
Cerebrovascular accident | 82.67 | 14.30 | 817 | 231469 | 100222 | 46353554 |
Sedation | 82.16 | 14.30 | 9 | 232277 | 22901 | 46430875 |
Gout | 81.65 | 14.30 | 177 | 232109 | 11179 | 46442597 |
Flatulence | 81.59 | 14.30 | 322 | 231964 | 28556 | 46425220 |
Glossodynia | 81.37 | 14.30 | 61 | 232225 | 44312 | 46409464 |
Device dislocation | 79.64 | 14.30 | 8 | 232278 | 21794 | 46431982 |
Gallbladder disorder | 79.57 | 14.30 | 229 | 232057 | 17269 | 46436507 |
Papule | 78.81 | 14.30 | 102 | 232184 | 4193 | 46449583 |
5q minus syndrome | 78.78 | 14.30 | 31 | 232255 | 155 | 46453621 |
Infection | 78.36 | 14.30 | 1012 | 231274 | 132580 | 46321196 |
Underdose | 77.49 | 14.30 | 5 | 232281 | 19553 | 46434223 |
Dysarthria | 76.21 | 14.30 | 46 | 232240 | 37452 | 46416324 |
No adverse event | 75.35 | 14.30 | 38 | 232248 | 34193 | 46419583 |
Bone pain | 75.11 | 14.30 | 444 | 231842 | 46446 | 46407330 |
Hepatic enzyme increased | 74.64 | 14.30 | 187 | 232099 | 81600 | 46372176 |
Toxic epidermal necrolysis | 74.45 | 14.30 | 11 | 232275 | 22267 | 46431509 |
Myalgia | 74.28 | 14.30 | 337 | 231949 | 122751 | 46331025 |
Device issue | 73.86 | 14.30 | 7 | 232279 | 19973 | 46433803 |
Acute lymphocytic leukaemia | 72.66 | 14.30 | 79 | 232207 | 2694 | 46451082 |
Pregnancy test false positive | 72.44 | 14.30 | 29 | 232257 | 153 | 46453623 |
Pregnancy | 71.34 | 14.30 | 23 | 232263 | 27114 | 46426662 |
Blood magnesium decreased | 70.82 | 14.30 | 164 | 232122 | 10828 | 46442948 |
Bronchitis | 70.43 | 14.30 | 822 | 231464 | 105157 | 46348619 |
Metabolic acidosis | 70.23 | 14.30 | 54 | 232232 | 38726 | 46415050 |
Renal impairment | 70.16 | 14.30 | 620 | 231666 | 73752 | 46380024 |
Generalised tonic-clonic seizure | 69.53 | 14.30 | 24 | 232262 | 27098 | 46426678 |
Discomfort | 69.17 | 14.30 | 78 | 232208 | 46592 | 46407184 |
Dyspnoea | 69.10 | 14.30 | 1996 | 230290 | 513552 | 45940224 |
Abnormal behaviour | 69 | 14.30 | 11 | 232275 | 21047 | 46432729 |
Incorrect route of product administration | 68.62 | 14.30 | 3 | 232283 | 16380 | 46437396 |
Gait disturbance | 68.61 | 14.30 | 432 | 231854 | 144831 | 46308945 |
Metastases to liver | 67.02 | 14.30 | 9 | 232277 | 19576 | 46434200 |
Blood pressure fluctuation | 66.72 | 14.30 | 34 | 232252 | 30414 | 46423362 |
Monoclonal immunoglobulin increased | 66.59 | 14.30 | 23 | 232263 | 73 | 46453703 |
Flushing | 66.01 | 14.30 | 139 | 232147 | 64475 | 46389301 |
Anaphylactic shock | 65.52 | 14.30 | 11 | 232275 | 20263 | 46433513 |
Withdrawal syndrome | 65.35 | 14.30 | 7 | 232279 | 18127 | 46435649 |
Unresponsive to stimuli | 64.64 | 14.30 | 40 | 232246 | 32134 | 46421642 |
Hypogeusia | 64.14 | 14.30 | 48 | 232238 | 991 | 46452785 |
Cardiac arrest | 63.63 | 14.30 | 233 | 232053 | 90166 | 46363610 |
Hip arthroplasty | 62.76 | 14.30 | 8 | 232278 | 18104 | 46435672 |
Drug ineffective for unapproved indication | 62.71 | 14.30 | 5 | 232281 | 16408 | 46437368 |
Heart rate increased | 62.20 | 14.30 | 179 | 232107 | 74612 | 46379164 |
Diverticulitis | 61.65 | 14.30 | 326 | 231960 | 32713 | 46421063 |
Musculoskeletal stiffness | 61.10 | 14.30 | 265 | 232021 | 97728 | 46356048 |
Dyskinesia | 60.88 | 14.30 | 34 | 232252 | 28891 | 46424885 |
Diabetic ketoacidosis | 60.84 | 14.30 | 9 | 232277 | 18201 | 46435575 |
Hepatitis | 60.74 | 14.30 | 43 | 232243 | 32172 | 46421604 |
Sleep apnoea syndrome | 59.82 | 14.30 | 18 | 232268 | 22183 | 46431593 |
Liver function test abnormal | 59.27 | 14.30 | 87 | 232199 | 46400 | 46407376 |
Intraductal proliferative breast lesion | 58.98 | 14.30 | 69 | 232217 | 2553 | 46451223 |
Hepatic steatosis | 58.72 | 14.30 | 23 | 232263 | 24019 | 46429757 |
Right ventricular failure | 58.54 | 14.30 | 6 | 232280 | 16087 | 46437689 |
Lymphoma | 58.44 | 14.30 | 142 | 232144 | 9671 | 46444105 |
Product prescribing error | 58.27 | 14.30 | 14 | 232272 | 20033 | 46433743 |
Obesity | 58.21 | 14.30 | 3 | 232283 | 14203 | 46439573 |
Acute leukaemia | 58.13 | 14.30 | 47 | 232239 | 1091 | 46452685 |
Hyperviscosity syndrome | 56.83 | 14.30 | 25 | 232261 | 173 | 46453603 |
Inflammation | 56.79 | 14.30 | 97 | 232189 | 48684 | 46405092 |
Joint range of motion decreased | 56.70 | 14.30 | 5 | 232281 | 15119 | 46438657 |
Spinal compression fracture | 55.92 | 14.30 | 166 | 232120 | 12737 | 46441039 |
Osteolysis | 55.89 | 14.30 | 67 | 232219 | 2545 | 46451231 |
Encephalopathy | 55.62 | 14.30 | 51 | 232235 | 33538 | 46420238 |
Type 2 diabetes mellitus | 55.61 | 14.30 | 15 | 232271 | 19860 | 46433916 |
Pallor | 55.21 | 14.30 | 23 | 232263 | 23143 | 46430633 |
Transaminases increased | 55.10 | 14.30 | 35 | 232251 | 27726 | 46426050 |
Herpes zoster | 55.09 | 14.30 | 548 | 231738 | 67324 | 46386452 |
Hallucination, visual | 54.95 | 14.30 | 11 | 232275 | 17862 | 46435914 |
Musculoskeletal pain | 54.62 | 14.30 | 173 | 232113 | 69955 | 46383821 |
Tumour lysis syndrome | 54.57 | 14.30 | 115 | 232171 | 7121 | 46446655 |
Eye disorder | 54.28 | 14.30 | 206 | 232080 | 17935 | 46435841 |
Fear | 54.01 | 14.30 | 8 | 232278 | 16164 | 46437612 |
Aggression | 53.53 | 14.30 | 23 | 232263 | 22721 | 46431055 |
Depressed mood | 53.52 | 14.30 | 52 | 232234 | 33267 | 46420509 |
Eye swelling | 53.47 | 14.30 | 220 | 232066 | 19883 | 46433893 |
Metastases to bone | 53.22 | 14.30 | 11 | 232275 | 17465 | 46436311 |
Drug-induced liver injury | 53.13 | 14.30 | 30 | 232256 | 25338 | 46428438 |
Cyanosis | 53.11 | 14.30 | 8 | 232278 | 15963 | 46437813 |
Agranulocytosis | 52.91 | 14.30 | 22 | 232264 | 22163 | 46431613 |
Compression fracture | 52.58 | 14.30 | 104 | 232182 | 6153 | 46447623 |
Hepatocellular injury | 52.33 | 14.30 | 42 | 232244 | 29480 | 46424296 |
Vitamin D decreased | 52.21 | 14.30 | 119 | 232167 | 7774 | 46446002 |
International normalised ratio increased | 52.08 | 14.30 | 96 | 232190 | 46787 | 46406989 |
Crying | 52.00 | 14.30 | 20 | 232266 | 21121 | 46432655 |
Blood bilirubin increased | 51.90 | 14.30 | 56 | 232230 | 34128 | 46419648 |
Memory impairment | 51.88 | 14.30 | 601 | 231685 | 76736 | 46377040 |
Accidental exposure to product | 51.76 | 14.30 | 20 | 232266 | 21061 | 46432715 |
Pancreatitis acute | 51.26 | 14.30 | 30 | 232256 | 24842 | 46428934 |
Blood iron decreased | 51.20 | 14.30 | 146 | 232140 | 10951 | 46442825 |
Impaired work ability | 50.75 | 14.30 | 3 | 232283 | 12633 | 46441143 |
Swelling face | 50.38 | 14.30 | 443 | 231843 | 52616 | 46401160 |
Lower respiratory tract infection | 50.22 | 14.30 | 126 | 232160 | 54963 | 46398813 |
Blood pressure diastolic decreased | 49.92 | 14.30 | 6 | 232280 | 14205 | 46439571 |
Pathological fracture | 49.45 | 14.30 | 117 | 232169 | 7833 | 46445943 |
Therapeutic response unexpected | 49.31 | 14.30 | 9 | 232277 | 15607 | 46438169 |
Hypoacusis | 49.24 | 14.30 | 221 | 232065 | 20748 | 46433028 |
Feeling jittery | 49.02 | 14.30 | 143 | 232143 | 10865 | 46442911 |
Liver injury | 48.88 | 14.30 | 10 | 232276 | 15991 | 46437785 |
Status epilepticus | 48.86 | 14.30 | 6 | 232280 | 13973 | 46439803 |
Angioedema | 48.83 | 14.30 | 75 | 232211 | 39267 | 46414509 |
Device malfunction | 48.61 | 14.30 | 5 | 232281 | 13369 | 46440407 |
Epilepsy | 48.40 | 14.30 | 29 | 232257 | 23709 | 46430067 |
Coronary artery disease | 48.30 | 14.30 | 58 | 232228 | 33694 | 46420082 |
Blood cholesterol increased | 48.03 | 14.30 | 78 | 232208 | 39935 | 46413841 |
B-cell lymphoma | 48.03 | 14.30 | 70 | 232216 | 3224 | 46450552 |
Procedural pain | 47.71 | 14.30 | 5 | 232281 | 13174 | 46440602 |
Stress | 47.70 | 14.30 | 117 | 232169 | 51434 | 46402342 |
White blood cell count abnormal | 47.67 | 14.30 | 89 | 232197 | 5043 | 46448733 |
Coronavirus infection | 47.63 | 14.30 | 64 | 232222 | 2730 | 46451046 |
Dyspnoea exertional | 47.43 | 14.30 | 113 | 232173 | 50176 | 46403600 |
Gastrointestinal disorder | 47.38 | 14.30 | 479 | 231807 | 59097 | 46394679 |
Cardiac failure congestive | 47.19 | 14.30 | 679 | 231607 | 91071 | 46362705 |
Increased tendency to bruise | 47.02 | 14.30 | 128 | 232158 | 9346 | 46444430 |
Clostridium difficile colitis | 46.97 | 14.30 | 200 | 232086 | 18353 | 46435423 |
Hyperlipidaemia | 46.50 | 14.30 | 17 | 232269 | 18522 | 46435254 |
Sinus tachycardia | 46.21 | 14.30 | 25 | 232261 | 21624 | 46432152 |
Adenocarcinoma of colon | 45.96 | 14.30 | 55 | 232231 | 2085 | 46451691 |
Acute kidney injury | 45.79 | 14.30 | 862 | 231424 | 234993 | 46218783 |
Leukocytosis | 45.75 | 14.30 | 30 | 232256 | 23368 | 46430408 |
Full blood count abnormal | 45.74 | 14.30 | 47 | 232239 | 1500 | 46452276 |
Hypercholesterolaemia | 45.52 | 14.30 | 3 | 232283 | 11527 | 46442249 |
Delirium | 45.22 | 14.30 | 72 | 232214 | 37156 | 46416620 |
Muscle spasticity | 45.10 | 14.30 | 3 | 232283 | 11437 | 46442339 |
Lower limb fracture | 44.99 | 14.30 | 150 | 232136 | 12248 | 46441528 |
Coagulopathy | 44.68 | 14.30 | 18 | 232268 | 18481 | 46435295 |
Fracture | 44.39 | 14.30 | 181 | 232105 | 16290 | 46437486 |
Extrapyramidal disorder | 44.29 | 14.30 | 3 | 232283 | 11265 | 46442511 |
Light chain analysis abnormal | 44.12 | 14.30 | 19 | 232267 | 124 | 46453652 |
Haematemesis | 43.94 | 14.30 | 47 | 232239 | 28759 | 46425017 |
Hepatotoxicity | 43.80 | 14.30 | 36 | 232250 | 24973 | 46428803 |
Myoclonus | 43.78 | 14.30 | 9 | 232277 | 14343 | 46439433 |
Oedema peripheral | 43.76 | 14.30 | 1072 | 231214 | 158634 | 46295142 |
Pneumonia aspiration | 43.45 | 14.30 | 56 | 232230 | 31549 | 46422227 |
Neutrophil count increased | 43.35 | 14.30 | 9 | 232277 | 14244 | 46439532 |
Human chorionic gonadotropin abnormal | 43.24 | 14.30 | 13 | 232273 | 22 | 46453754 |
Blood electrolytes decreased | 43.23 | 14.30 | 38 | 232248 | 993 | 46452783 |
Hypothermia | 43.15 | 14.30 | 5 | 232281 | 12178 | 46441598 |
General physical health deterioration | 42.78 | 14.30 | 369 | 231917 | 115400 | 46338376 |
COVID-19 pneumonia | 42.62 | 14.30 | 66 | 232220 | 3209 | 46450567 |
Blood potassium abnormal | 42.46 | 14.30 | 52 | 232234 | 2020 | 46451756 |
Pulmonary hypertension | 42.42 | 14.30 | 71 | 232215 | 35922 | 46417854 |
Transformation to acute myeloid leukaemia | 42.38 | 14.30 | 18 | 232268 | 113 | 46453663 |
Weight decreased | 42.31 | 14.30 | 1360 | 230926 | 209489 | 46244287 |
Injection site rash | 42.28 | 14.30 | 13 | 232273 | 15800 | 46437976 |
Colitis ulcerative | 41.63 | 14.30 | 18 | 232268 | 17714 | 46436062 |
Sputum discoloured | 41.14 | 14.30 | 7 | 232279 | 12771 | 46441005 |
Leukaemia | 40.93 | 14.30 | 65 | 232221 | 3230 | 46450546 |
Cholestasis | 40.89 | 14.30 | 44 | 232242 | 26849 | 46426927 |
Cholecystitis chronic | 40.67 | 14.30 | 3 | 232283 | 10496 | 46443280 |
Respiratory depression | 40.49 | 14.30 | 5 | 232281 | 11595 | 46442181 |
Altered state of consciousness | 40.41 | 14.30 | 34 | 232252 | 23314 | 46430462 |
Psychotic disorder | 40.32 | 14.30 | 32 | 232254 | 22589 | 46431187 |
Gastrointestinal haemorrhage | 40.27 | 14.30 | 223 | 232063 | 77150 | 46376626 |
Protein total abnormal | 40.26 | 14.30 | 24 | 232262 | 333 | 46453443 |
Product administration error | 40.19 | 14.30 | 24 | 232262 | 19657 | 46434119 |
Jaundice | 39.77 | 14.30 | 51 | 232235 | 28794 | 46424982 |
Hallucination | 39.76 | 14.30 | 122 | 232164 | 49829 | 46403947 |
Iron deficiency anaemia | 39.55 | 14.30 | 18 | 232268 | 17188 | 46436588 |
Rib fracture | 39.54 | 14.30 | 193 | 232093 | 18761 | 46435015 |
Respiratory distress | 39.46 | 14.30 | 61 | 232225 | 31855 | 46421921 |
Angina pectoris | 39.40 | 14.30 | 45 | 232241 | 26730 | 46427046 |
Circulatory collapse | 39.29 | 14.30 | 30 | 232256 | 21594 | 46432182 |
Blood urea increased | 39.08 | 14.30 | 41 | 232245 | 25311 | 46428465 |
Complication associated with device | 39 | 14.30 | 14 | 232272 | 15427 | 46438349 |
Product storage error | 39.00 | 14.30 | 6 | 232280 | 11786 | 46441990 |
Transfusion | 38.93 | 14.30 | 9 | 232277 | 13222 | 46440554 |
Accidental overdose | 38.87 | 14.30 | 26 | 232260 | 20040 | 46433736 |
Drug resistance | 38.65 | 14.30 | 19 | 232267 | 17349 | 46436427 |
Arthritis | 38.53 | 14.30 | 226 | 232060 | 77090 | 46376686 |
Joint stiffness | 38.35 | 14.30 | 47 | 232239 | 27061 | 46426715 |
Hypoxia | 38.21 | 14.30 | 131 | 232155 | 51707 | 46402069 |
Failure to thrive | 38.17 | 14.30 | 95 | 232191 | 6569 | 46447207 |
Muscle rigidity | 38.15 | 14.30 | 3 | 232283 | 9958 | 46443818 |
Tachypnoea | 38.01 | 14.30 | 12 | 232274 | 14339 | 46439437 |
Blood lactate dehydrogenase increased | 37.81 | 14.30 | 28 | 232258 | 20472 | 46433304 |
Pericarditis | 37.67 | 14.30 | 38 | 232248 | 23889 | 46429887 |
Dysphonia | 37.65 | 14.30 | 323 | 231963 | 38091 | 46415685 |
Abortion induced | 36.87 | 14.30 | 4 | 232282 | 10256 | 46443520 |
Gastritis | 36.77 | 14.30 | 72 | 232214 | 34306 | 46419470 |
Impaired healing | 36.72 | 14.30 | 80 | 232206 | 36663 | 46417113 |
Blood calcium decreased | 36.66 | 14.30 | 165 | 232121 | 15508 | 46438268 |
Invasive ductal breast carcinoma | 36.46 | 14.30 | 89 | 232197 | 6079 | 46447697 |
Disability | 36.44 | 14.30 | 4 | 232282 | 10163 | 46443613 |
Palmar-plantar erythrodysaesthesia syndrome | 36.36 | 14.30 | 29 | 232257 | 20422 | 46433354 |
Melaena | 36.36 | 14.30 | 51 | 232235 | 27721 | 46426055 |
Vitamin B12 decreased | 36.22 | 14.30 | 56 | 232230 | 2719 | 46451057 |
Blood calcium increased | 36.16 | 14.30 | 101 | 232185 | 7486 | 46446290 |
Blood immunoglobulin G increased | 36.10 | 14.30 | 37 | 232249 | 1177 | 46452599 |
Speech disorder | 35.94 | 14.30 | 79 | 232207 | 36088 | 46417688 |
Wound | 35.90 | 14.30 | 102 | 232184 | 42700 | 46411076 |
Skin cancer | 35.88 | 14.30 | 111 | 232175 | 8712 | 46445064 |
Hypotension | 35.85 | 14.30 | 882 | 231404 | 231707 | 46222069 |
Bone erosion | 35.73 | 14.30 | 3 | 232283 | 9440 | 46444336 |
Bone marrow failure | 35.39 | 14.30 | 261 | 232025 | 29408 | 46424368 |
Anosmia | 34.90 | 14.30 | 67 | 232219 | 3877 | 46449899 |
Hypercalcaemia | 34.80 | 14.30 | 201 | 232085 | 20845 | 46432931 |
Respiratory syncytial virus infection | 34.34 | 14.30 | 75 | 232211 | 4760 | 46449016 |
Obstructive airways disorder | 34.15 | 14.30 | 12 | 232274 | 13400 | 46440376 |
Body temperature decreased | 34.14 | 14.30 | 12 | 232274 | 13397 | 46440379 |
Metastases to lung | 34.13 | 14.30 | 6 | 232280 | 10690 | 46443086 |
Rales | 33.99 | 14.30 | 4 | 232282 | 9627 | 46444149 |
Lethargy | 33.99 | 14.30 | 135 | 232151 | 51036 | 46402740 |
Haematoma | 33.87 | 14.30 | 67 | 232219 | 31805 | 46421971 |
Peritonitis | 33.65 | 14.30 | 32 | 232254 | 20682 | 46433094 |
Ovarian cyst | 33.55 | 14.30 | 14 | 232272 | 14073 | 46439703 |
Blood immunoglobulin A increased | 33.21 | 14.30 | 22 | 232264 | 371 | 46453405 |
Panic attack | 33.20 | 14.30 | 31 | 232255 | 20211 | 46433565 |
Therapeutic response decreased | 33.19 | 14.30 | 107 | 232179 | 43038 | 46410738 |
Mitral valve incompetence | 33.18 | 14.30 | 27 | 232259 | 18825 | 46434951 |
Blood pressure decreased | 32.98 | 14.30 | 159 | 232127 | 57000 | 46396776 |
Pneumonia influenzal | 32.77 | 14.30 | 39 | 232247 | 1470 | 46452306 |
Torsade de pointes | 32.48 | 14.30 | 10 | 232276 | 12144 | 46441632 |
Pancreatitis | 32.32 | 14.30 | 110 | 232176 | 43517 | 46410259 |
Hallucination, auditory | 32.28 | 14.30 | 7 | 232279 | 10749 | 46443027 |
Urinary retention | 32.03 | 14.30 | 50 | 232236 | 26011 | 46427765 |
Pain in jaw | 31.78 | 14.30 | 92 | 232194 | 38280 | 46415496 |
Chronic lymphocytic leukaemia | 31.70 | 14.30 | 54 | 232232 | 2846 | 46450930 |
Vertigo | 31.67 | 14.30 | 142 | 232144 | 51906 | 46401870 |
Refractory cytopenia with multilineage dysplasia | 31.54 | 14.30 | 15 | 232271 | 127 | 46453649 |
Malignant neoplasm of unknown primary site | 31.48 | 14.30 | 19 | 232267 | 270 | 46453506 |
Transplant rejection | 31.47 | 14.30 | 5 | 232281 | 9591 | 46444185 |
Nail discolouration | 31.41 | 14.30 | 47 | 232239 | 2217 | 46451559 |
Middle insomnia | 31.11 | 14.30 | 5 | 232281 | 9510 | 46444266 |
Eye infection | 31.02 | 14.30 | 108 | 232178 | 9015 | 46444761 |
Chest pain | 31.01 | 14.30 | 655 | 231631 | 175669 | 46278107 |
Post procedural complication | 30.98 | 14.30 | 20 | 232266 | 15709 | 46438067 |
Hypokinesia | 30.83 | 14.30 | 9 | 232277 | 11313 | 46442463 |
Ear swelling | 30.77 | 14.30 | 32 | 232254 | 1036 | 46452740 |
Abdominal pain lower | 30.73 | 14.30 | 36 | 232250 | 21145 | 46432631 |
Hypothyroidism | 30.69 | 14.30 | 69 | 232217 | 31269 | 46422507 |
Upper respiratory tract infection | 30.57 | 14.30 | 465 | 231821 | 63091 | 46390685 |
Tricuspid valve incompetence | 30.53 | 14.30 | 15 | 232271 | 13702 | 46440074 |
Nausea | 30.50 | 14.30 | 2977 | 229309 | 684477 | 45769299 |
White blood cell count increased | 30.43 | 14.30 | 115 | 232171 | 44104 | 46409672 |
Gastrointestinal motility disorder | 30.16 | 14.30 | 68 | 232218 | 4410 | 46449366 |
Osteonecrosis | 30.14 | 14.30 | 51 | 232235 | 25693 | 46428083 |
POEMS syndrome | 30.02 | 14.30 | 8 | 232278 | 6 | 46453770 |
Hepatic failure | 30.01 | 14.30 | 77 | 232209 | 33339 | 46420437 |
Dry eye | 29.73 | 14.30 | 255 | 232031 | 30067 | 46423709 |
Shock | 29.73 | 14.30 | 39 | 232247 | 21806 | 46431970 |
Liver function test decreased | 29.52 | 14.30 | 11 | 232275 | 46 | 46453730 |
Respiratory rate increased | 29.51 | 14.30 | 10 | 232276 | 11423 | 46442353 |
Upper gastrointestinal haemorrhage | 29.43 | 14.30 | 24 | 232262 | 16714 | 46437062 |
Pulmonary fibrosis | 29.31 | 14.30 | 34 | 232252 | 20058 | 46433718 |
White blood cell disorder | 29.28 | 14.30 | 42 | 232244 | 1906 | 46451870 |
Incorrect product administration duration | 29.22 | 14.30 | 6 | 232280 | 9571 | 46444205 |
Schizophrenia | 29.17 | 14.30 | 4 | 232282 | 8564 | 46445212 |
Hyperglycaemia | 29.10 | 14.30 | 84 | 232202 | 34987 | 46418789 |
Mucosal inflammation | 29.06 | 14.30 | 98 | 232188 | 38878 | 46414898 |
Food poisoning | 28.99 | 14.30 | 54 | 232232 | 3054 | 46450722 |
Parkinsonism | 28.81 | 14.30 | 3 | 232283 | 7945 | 46445831 |
Muscle strain | 28.63 | 14.30 | 87 | 232199 | 6762 | 46447014 |
Myositis | 28.61 | 14.30 | 3 | 232283 | 7901 | 46445875 |
Back pain | 28.54 | 14.30 | 1298 | 230988 | 208741 | 46245035 |
Scar | 28.53 | 14.30 | 12 | 232274 | 12007 | 46441769 |
Dysphagia | 28.29 | 14.30 | 247 | 232039 | 77065 | 46376711 |
Tuberculosis | 28.25 | 14.30 | 8 | 232278 | 10257 | 46443519 |
Breath sounds abnormal | 28.20 | 14.30 | 3 | 232283 | 7812 | 46445964 |
Platelet count abnormal | 28.19 | 14.30 | 50 | 232236 | 2722 | 46451054 |
Hepatic function abnormal | 28.16 | 14.30 | 83 | 232203 | 34338 | 46419438 |
Uterine disorder | 28.00 | 14.30 | 49 | 232237 | 2639 | 46451137 |
Aphasia | 27.89 | 14.30 | 63 | 232223 | 28504 | 46425272 |
Neuralgia | 27.76 | 14.30 | 192 | 232094 | 21191 | 46432585 |
Paraesthesia | 27.71 | 14.30 | 773 | 231513 | 116664 | 46337112 |
Acute hepatic failure | 27.29 | 14.30 | 20 | 232266 | 14701 | 46439075 |
Foot deformity | 27.27 | 14.30 | 22 | 232264 | 15403 | 46438373 |
Diabetes mellitus inadequate control | 27.14 | 14.30 | 16 | 232270 | 13198 | 46440578 |
Sleep disorder | 27.09 | 14.30 | 130 | 232156 | 46665 | 46407111 |
Cardiogenic shock | 26.98 | 14.30 | 25 | 232261 | 16359 | 46437417 |
Oral disorder | 26.94 | 14.30 | 93 | 232193 | 7729 | 46446047 |
Myocardial ischaemia | 26.81 | 14.30 | 15 | 232271 | 12734 | 46441042 |
Affect lability | 26.71 | 14.30 | 4 | 232282 | 8016 | 46445760 |
Refractory anaemia with an excess of blasts | 26.64 | 14.30 | 20 | 232266 | 415 | 46453361 |
Spinal disorder | 26.43 | 14.30 | 94 | 232192 | 7930 | 46445846 |
Left ventricular dysfunction | 26.41 | 14.30 | 9 | 232277 | 10246 | 46443530 |
Neurotoxicity | 26.26 | 14.30 | 18 | 232268 | 13699 | 46440077 |
Posterior reversible encephalopathy syndrome | 26.26 | 14.30 | 22 | 232264 | 15119 | 46438657 |
Blood triglycerides increased | 26.05 | 14.30 | 13 | 232273 | 11770 | 46442006 |
Stomatitis | 25.99 | 14.30 | 481 | 231805 | 67816 | 46385960 |
Helicobacter infection | 25.87 | 14.30 | 13 | 232273 | 11723 | 46442053 |
Hysterectomy | 25.75 | 14.30 | 4 | 232282 | 7802 | 46445974 |
Ventricular tachycardia | 25.53 | 14.30 | 28 | 232258 | 16939 | 46436837 |
Rhinorrhoea | 25.39 | 14.30 | 355 | 231931 | 47310 | 46406466 |
Metastases to central nervous system | 25.39 | 14.30 | 12 | 232274 | 11209 | 46442567 |
Mood swings | 25.37 | 14.30 | 26 | 232260 | 16226 | 46437550 |
Red cell distribution width increased | 25.29 | 14.30 | 4 | 232282 | 7700 | 46446076 |
Delusion | 25.26 | 14.30 | 12 | 232274 | 11176 | 46442600 |
Proteinuria | 25.25 | 14.30 | 27 | 232259 | 16526 | 46437250 |
Spinal osteoarthritis | 25.24 | 14.30 | 20 | 232266 | 14131 | 46439645 |
Eczema | 25.21 | 14.30 | 39 | 232247 | 20361 | 46433415 |
Blood calcium abnormal | 25.14 | 14.30 | 26 | 232260 | 836 | 46452940 |
Shock haemorrhagic | 25.11 | 14.30 | 6 | 232280 | 8618 | 46445158 |
Cholecystectomy | 24.97 | 14.30 | 7 | 232279 | 9035 | 46444741 |
Ventricular fibrillation | 24.94 | 14.30 | 13 | 232273 | 11483 | 46442293 |
Colitis | 24.92 | 14.30 | 290 | 231996 | 37057 | 46416719 |
Protein total decreased | 24.84 | 14.30 | 72 | 232214 | 5451 | 46448325 |
Angina unstable | 24.60 | 14.30 | 4 | 232282 | 7544 | 46446232 |
Viral infection | 24.46 | 14.30 | 244 | 232042 | 29991 | 46423785 |
Feeding disorder | 24.35 | 14.30 | 108 | 232178 | 10086 | 46443690 |
Hepatic encephalopathy | 24.34 | 14.30 | 10 | 232276 | 10147 | 46443629 |
Thrombophlebitis superficial | 24.24 | 14.30 | 67 | 232219 | 4936 | 46448840 |
Blood magnesium abnormal | 24.21 | 14.30 | 19 | 232267 | 422 | 46453354 |
Injection site discolouration | 24.07 | 14.30 | 3 | 232283 | 6907 | 46446869 |
Cardiomegaly | 24.01 | 14.30 | 31 | 232255 | 17451 | 46436325 |
Lacrimation increased | 23.99 | 14.30 | 148 | 232138 | 15713 | 46438063 |
Asthma | 23.99 | 14.30 | 316 | 231970 | 91226 | 46362550 |
Rash macular | 23.87 | 14.30 | 171 | 232115 | 19089 | 46434687 |
Allergic sinusitis | 23.86 | 14.30 | 20 | 232266 | 489 | 46453287 |
Nervousness | 23.62 | 14.30 | 231 | 232055 | 28244 | 46425532 |
Chills | 23.55 | 14.30 | 336 | 231950 | 95696 | 46358080 |
Tooth infection | 23.44 | 14.30 | 122 | 232164 | 12164 | 46441612 |
Hypotonia | 23.42 | 14.30 | 6 | 232280 | 8223 | 46445553 |
Therapy cessation | 23.42 | 14.30 | 62 | 232224 | 26567 | 46427209 |
Productive cough | 23.31 | 14.30 | 152 | 232134 | 50563 | 46403213 |
Uveitis | 23.29 | 14.30 | 7 | 232279 | 8634 | 46445142 |
Hemiparesis | 23.27 | 14.30 | 40 | 232246 | 20029 | 46433747 |
Anuria | 23.25 | 14.30 | 14 | 232272 | 11417 | 46442359 |
Basal cell carcinoma | 23.18 | 14.30 | 178 | 232108 | 20309 | 46433467 |
Photophobia | 23.01 | 14.30 | 23 | 232263 | 14521 | 46439255 |
Miosis | 22.92 | 14.30 | 3 | 232283 | 6654 | 46447122 |
Pulseless electrical activity | 22.91 | 14.30 | 4 | 232282 | 7163 | 46446613 |
Eyelid cyst | 22.80 | 14.30 | 6 | 232280 | 4 | 46453772 |
Metastases to lymph nodes | 22.80 | 14.30 | 3 | 232283 | 6628 | 46447148 |
Pseudomonas infection | 22.75 | 14.30 | 10 | 232276 | 9748 | 46444028 |
Sinus bradycardia | 22.73 | 14.30 | 21 | 232265 | 13761 | 46440015 |
Ejection fraction decreased | 22.44 | 14.30 | 34 | 232252 | 17903 | 46435873 |
Illness | 22.38 | 14.30 | 120 | 232166 | 12104 | 46441672 |
Chondrocalcinosis pyrophosphate | 22.37 | 14.30 | 26 | 232260 | 955 | 46452821 |
Pelvic fracture | 22.31 | 14.30 | 115 | 232171 | 11424 | 46442352 |
Irritability | 22.12 | 14.30 | 72 | 232214 | 28874 | 46424902 |
Restlessness | 22.02 | 14.30 | 60 | 232226 | 25464 | 46428312 |
Post procedural haemorrhage | 21.95 | 14.30 | 5 | 232281 | 7421 | 46446355 |
Influenza like illness | 21.92 | 14.30 | 182 | 232104 | 57388 | 46396388 |
Cellulitis | 21.75 | 14.30 | 480 | 231806 | 69808 | 46383968 |
Blood pressure abnormal | 21.73 | 14.30 | 119 | 232167 | 12098 | 46441678 |
Tremor | 21.64 | 14.30 | 740 | 231546 | 114899 | 46338877 |
Optic neuritis | 21.61 | 14.30 | 4 | 232282 | 6867 | 46446909 |
Tubulointerstitial nephritis | 21.60 | 14.30 | 25 | 232261 | 14763 | 46439013 |
Disease complication | 21.57 | 14.30 | 47 | 232239 | 2978 | 46450798 |
Bronchospasm | 21.42 | 14.30 | 28 | 232258 | 15679 | 46438097 |
Grip strength decreased | 21.40 | 14.30 | 8 | 232278 | 8598 | 46445178 |
Skin necrosis | 21.39 | 14.30 | 8 | 232278 | 8596 | 46445180 |
Lipase increased | 21.39 | 14.30 | 8 | 232278 | 8595 | 46445181 |
Joint effusion | 21.34 | 14.30 | 17 | 232269 | 11978 | 46441798 |
Atelectasis | 21.29 | 14.30 | 38 | 232248 | 18752 | 46435024 |
Glycosylated haemoglobin increased | 21.19 | 14.30 | 14 | 232272 | 10862 | 46442914 |
Osteoporosis | 21.14 | 14.30 | 117 | 232169 | 40491 | 46413285 |
Lymphopenia | 21.12 | 14.30 | 27 | 232259 | 15266 | 46438510 |
Platelet disorder | 21.05 | 14.30 | 32 | 232254 | 1531 | 46452245 |
Peripheral coldness | 21.02 | 14.30 | 101 | 232185 | 9754 | 46444022 |
Mouth ulceration | 21.02 | 14.30 | 66 | 232220 | 26766 | 46427010 |
Large intestine infection | 20.96 | 14.30 | 31 | 232255 | 1447 | 46452329 |
Bursitis | 20.84 | 14.30 | 42 | 232244 | 19800 | 46433976 |
Major depression | 20.81 | 14.30 | 4 | 232282 | 6686 | 46447090 |
Haemodialysis | 20.63 | 14.30 | 10 | 232276 | 9207 | 46444569 |
Acute respiratory failure | 20.56 | 14.30 | 75 | 232211 | 29063 | 46424713 |
Endometrial adenocarcinoma | 20.49 | 14.30 | 27 | 232259 | 1130 | 46452646 |
Osteopenia | 20.41 | 14.30 | 33 | 232253 | 16928 | 46436848 |
Rectal adenocarcinoma | 20.39 | 14.30 | 20 | 232266 | 603 | 46453173 |
Oliguria | 20.39 | 14.30 | 9 | 232277 | 8750 | 46445026 |
Swelling | 20.30 | 14.30 | 468 | 231818 | 124043 | 46329733 |
Nightmare | 20.25 | 14.30 | 32 | 232254 | 16566 | 46437210 |
Skin hyperpigmentation | 20.15 | 14.30 | 65 | 232221 | 5217 | 46448559 |
Coordination abnormal | 20.13 | 14.30 | 15 | 232271 | 10934 | 46442842 |
Movement disorder | 20.07 | 14.30 | 33 | 232253 | 16816 | 46436960 |
Low density lipoprotein increased | 19.96 | 14.30 | 3 | 232283 | 5997 | 46447779 |
Device failure | 19.78 | 14.30 | 3 | 232283 | 5956 | 46447820 |
Gastrooesophageal reflux disease | 19.71 | 14.30 | 256 | 232030 | 74088 | 46379688 |
Apnoea | 19.68 | 14.30 | 6 | 232280 | 7333 | 46446443 |
Arteriosclerosis coronary artery | 19.59 | 14.30 | 8 | 232278 | 8148 | 46445628 |
Hydronephrosis | 19.54 | 14.30 | 9 | 232277 | 8536 | 46445240 |
Performance status decreased | 19.44 | 14.30 | 47 | 232239 | 3190 | 46450586 |
Brain oedema | 19.43 | 14.30 | 20 | 232266 | 12458 | 46441318 |
Disorientation | 19.42 | 14.30 | 106 | 232180 | 36812 | 46416964 |
Cerebral infarction | 19.36 | 14.30 | 56 | 232230 | 23310 | 46430466 |
Oesophageal squamous cell carcinoma | 19.35 | 14.30 | 10 | 232276 | 103 | 46453673 |
Pyelonephritis | 19.32 | 14.30 | 29 | 232257 | 15328 | 46438448 |
Muscular weakness | 19.26 | 14.30 | 331 | 231955 | 91513 | 46362263 |
Product dispensing error | 19.22 | 14.30 | 11 | 232275 | 9222 | 46444554 |
Plasma cell myeloma in remission | 19.21 | 14.30 | 5 | 232281 | 3 | 46453773 |
Muscle twitching | 19.15 | 14.30 | 27 | 232259 | 14645 | 46439131 |
Chalazion | 19.09 | 14.30 | 14 | 232272 | 280 | 46453496 |
Ataxia | 18.82 | 14.30 | 25 | 232261 | 13905 | 46439871 |
Night sweats | 18.81 | 14.30 | 213 | 232073 | 27037 | 46426739 |
Tardive dyskinesia | 18.78 | 14.30 | 7 | 232279 | 7536 | 46446240 |
Hypersensitivity | 18.76 | 14.30 | 587 | 231699 | 149734 | 46304042 |
Carcinoid tumour of the appendix | 18.70 | 14.30 | 6 | 232280 | 14 | 46453762 |
Pleural effusion | 18.69 | 14.30 | 295 | 231991 | 82657 | 46371119 |
Mania | 18.52 | 14.30 | 16 | 232270 | 10830 | 46442946 |
Disseminated intravascular coagulation | 18.48 | 14.30 | 42 | 232244 | 18963 | 46434813 |
Respiratory acidosis | 18.45 | 14.30 | 4 | 232282 | 6144 | 46447632 |
Haematuria | 18.38 | 14.30 | 70 | 232216 | 26788 | 46426988 |
Target skin lesion | 18.36 | 14.30 | 9 | 232277 | 82 | 46453694 |
Physical deconditioning | 18.34 | 14.30 | 14 | 232272 | 298 | 46453478 |
Swollen tongue | 18.24 | 14.30 | 79 | 232207 | 29153 | 46424623 |
Polyarthritis | 18.19 | 14.30 | 5 | 232281 | 6537 | 46447239 |
Superficial spreading melanoma stage unspecified | 18.03 | 14.30 | 10 | 232276 | 120 | 46453656 |
Gingival pain | 18.00 | 14.30 | 69 | 232217 | 6034 | 46447742 |
Kidney infection | 17.96 | 14.30 | 144 | 232142 | 16645 | 46437131 |
Amenorrhoea | 17.95 | 14.30 | 11 | 232275 | 8884 | 46444892 |
Parainfluenzae virus infection | 17.91 | 14.30 | 32 | 232254 | 1752 | 46452024 |
Spinal operation | 17.91 | 14.30 | 3 | 232283 | 5537 | 46448239 |
Gastrointestinal fungal infection | 17.85 | 14.30 | 13 | 232273 | 257 | 46453519 |
Myeloma cast nephropathy | 17.75 | 14.30 | 10 | 232276 | 124 | 46453652 |
Motor dysfunction | 17.73 | 14.30 | 7 | 232279 | 7275 | 46446501 |
Blood pressure diastolic increased | 17.70 | 14.30 | 4 | 232282 | 5970 | 46447806 |
Renal injury | 17.64 | 14.30 | 13 | 232273 | 9528 | 46444248 |
Sensory disturbance | 17.63 | 14.30 | 21 | 232265 | 12246 | 46441530 |
Malignant melanoma in situ | 17.47 | 14.30 | 21 | 232265 | 800 | 46452976 |
Throat tightness | 17.44 | 14.30 | 49 | 232237 | 20590 | 46433186 |
Epstein-Barr virus infection | 17.39 | 14.30 | 6 | 232280 | 6778 | 46446998 |
Deafness | 17.29 | 14.30 | 138 | 232148 | 15930 | 46437846 |
Lentigo maligna | 17.26 | 14.30 | 11 | 232275 | 173 | 46453603 |
Viral upper respiratory tract infection | 17.26 | 14.30 | 75 | 232211 | 6943 | 46446833 |
Red blood cell count abnormal | 17.25 | 14.30 | 22 | 232264 | 891 | 46452885 |
Precursor B-lymphoblastic lymphoma | 17.20 | 14.30 | 5 | 232281 | 7 | 46453769 |
Oral herpes | 17.16 | 14.30 | 45 | 232241 | 19345 | 46434431 |
Acute generalised exanthematous pustulosis | 17.15 | 14.30 | 13 | 232273 | 9392 | 46444384 |
Oedema | 17.03 | 14.30 | 233 | 232053 | 66838 | 46386938 |
Cushingoid | 17.03 | 14.30 | 5 | 232281 | 6261 | 46447515 |
Colon cancer | 16.97 | 14.30 | 91 | 232195 | 9178 | 46444598 |
Laryngeal oedema | 16.93 | 14.30 | 3 | 232283 | 5316 | 46448460 |
Localised infection | 16.86 | 14.30 | 187 | 232099 | 23614 | 46430162 |
Pain in extremity | 16.85 | 14.30 | 1085 | 231201 | 257595 | 46196181 |
Hepatic cirrhosis | 16.78 | 14.30 | 33 | 232253 | 15699 | 46438077 |
Folliculitis | 16.76 | 14.30 | 5 | 232281 | 6198 | 46447578 |
Central nervous system lesion | 16.64 | 14.30 | 14 | 232272 | 9601 | 46444175 |
Gingival bleeding | 16.61 | 14.30 | 107 | 232179 | 11532 | 46442244 |
Abdominal discomfort | 16.59 | 14.30 | 600 | 231686 | 150565 | 46303211 |
Brain injury | 16.54 | 14.30 | 5 | 232281 | 6145 | 46447631 |
Nystagmus | 16.52 | 14.30 | 4 | 232282 | 5695 | 46448081 |
Genital haemorrhage | 16.50 | 14.30 | 6 | 232280 | 6560 | 46447216 |
Pemphigoid | 16.49 | 14.30 | 4 | 232282 | 5687 | 46448089 |
Disturbance in attention | 16.39 | 14.30 | 91 | 232195 | 31469 | 46422307 |
Uterine leiomyoma | 16.36 | 14.30 | 10 | 232276 | 8089 | 46445687 |
Blood lactic acid increased | 16.34 | 14.30 | 4 | 232282 | 5653 | 46448123 |
Paraproteinaemia | 16.34 | 14.30 | 10 | 232276 | 146 | 46453630 |
Nasal abscess | 16.34 | 14.30 | 10 | 232276 | 146 | 46453630 |
Anger | 16.29 | 14.30 | 21 | 232265 | 11831 | 46441945 |
Pneumothorax | 16.20 | 14.30 | 30 | 232256 | 14599 | 46439177 |
Pharyngitis | 16.19 | 14.30 | 40 | 232246 | 17543 | 46436233 |
Activated partial thromboplastin time prolonged | 16.16 | 14.30 | 7 | 232279 | 6882 | 46446894 |
Breast cancer metastatic | 16.10 | 14.30 | 27 | 232259 | 13651 | 46440125 |
Deformity | 16.05 | 14.30 | 8 | 232278 | 7249 | 46446527 |
Fistula | 16.03 | 14.30 | 10 | 232276 | 8000 | 46445776 |
Clavicle fracture | 15.99 | 14.30 | 41 | 232245 | 2888 | 46450888 |
Duodenal ulcer | 15.90 | 14.30 | 8 | 232278 | 7210 | 46446566 |
Sternal fracture | 15.87 | 14.30 | 28 | 232258 | 1518 | 46452258 |
Arteriosclerosis | 15.85 | 14.30 | 15 | 232271 | 9718 | 46444058 |
Pneumonitis | 15.84 | 14.30 | 80 | 232206 | 28340 | 46425436 |
Bundle branch block left | 15.83 | 14.30 | 6 | 232280 | 6393 | 46447383 |
Hiatus hernia | 15.80 | 14.30 | 43 | 232243 | 18259 | 46435517 |
Malignant melanoma | 15.80 | 14.30 | 96 | 232190 | 10138 | 46443638 |
Bipolar disorder | 15.74 | 14.30 | 8 | 232278 | 7169 | 46446607 |
Therapy non-responder | 15.71 | 14.30 | 290 | 231996 | 40862 | 46412914 |
Device occlusion | 15.69 | 14.30 | 5 | 232281 | 5940 | 46447836 |
Hypoaesthesia oral | 15.64 | 14.30 | 98 | 232188 | 10461 | 46443315 |
Partial seizures | 15.58 | 14.30 | 3 | 232283 | 5007 | 46448769 |
Visual acuity reduced | 15.54 | 14.30 | 57 | 232229 | 22056 | 46431720 |
Amnesia | 15.42 | 14.30 | 292 | 231994 | 41339 | 46412437 |
Gastroenteritis | 15.39 | 14.30 | 65 | 232221 | 24154 | 46429622 |
Paranoia | 15.38 | 14.30 | 18 | 232268 | 10579 | 46443197 |
Musculoskeletal disorder | 15.38 | 14.30 | 131 | 232155 | 15414 | 46438362 |
Encephalitis | 15.32 | 14.30 | 9 | 232277 | 7439 | 46446337 |
Liver function test increased | 15.29 | 14.30 | 60 | 232226 | 22766 | 46431010 |
Pigmentation disorder | 15.21 | 14.30 | 47 | 232239 | 3686 | 46450090 |
Acidosis | 15.15 | 14.30 | 20 | 232266 | 11154 | 46442622 |
Bradyphrenia | 15.15 | 14.30 | 6 | 232280 | 6224 | 46447552 |
Foreign body in respiratory tract | 15.08 | 14.30 | 12 | 232274 | 272 | 46453504 |
Respiratory tract congestion | 15.06 | 14.30 | 112 | 232174 | 12652 | 46441124 |
Hypertensive crisis | 15.01 | 14.30 | 28 | 232258 | 13587 | 46440189 |
Gastric ulcer | 14.95 | 14.30 | 57 | 232229 | 21806 | 46431970 |
Hyperbilirubinaemia | 14.86 | 14.30 | 18 | 232268 | 10420 | 46443356 |
Cervical vertebral fracture | 14.77 | 14.30 | 34 | 232252 | 2236 | 46451540 |
Balance disorder | 14.73 | 14.30 | 423 | 231863 | 64098 | 46389678 |
Rhinitis allergic | 14.71 | 14.30 | 8 | 232278 | 6900 | 46446876 |
Hypertriglyceridaemia | 14.70 | 14.30 | 5 | 232281 | 5699 | 46448077 |
Infusion site extravasation | 14.64 | 14.30 | 4 | 232282 | 5252 | 46448524 |
Eye movement disorder | 14.63 | 14.30 | 3 | 232283 | 4790 | 46448986 |
Invasive lobular breast carcinoma | 14.62 | 14.30 | 17 | 232269 | 625 | 46453151 |
Urethral cancer | 14.48 | 14.30 | 4 | 232282 | 4 | 46453772 |
Bronchiectasis | 14.43 | 14.30 | 15 | 232271 | 9301 | 46444475 |
Weight fluctuation | 14.43 | 14.30 | 68 | 232218 | 6516 | 46447260 |
Urinary incontinence | 14.42 | 14.30 | 83 | 232203 | 28447 | 46425329 |
Hepatomegaly | 14.40 | 14.30 | 21 | 232265 | 11232 | 46442544 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Plasma cell myeloma | 12907.47 | 14.07 | 6873 | 226282 | 46589 | 29672734 |
Death | 4492.91 | 14.07 | 9048 | 224107 | 348235 | 29371088 |
Full blood count decreased | 4080.79 | 14.07 | 2128 | 231027 | 13589 | 29705734 |
Thrombosis | 2914.97 | 14.07 | 2502 | 230653 | 39729 | 29679594 |
Pneumonia | 2600.44 | 14.07 | 7029 | 226126 | 327277 | 29392046 |
Neuropathy peripheral | 2344.94 | 14.07 | 2813 | 230342 | 67662 | 29651661 |
White blood cell count decreased | 2090.40 | 14.07 | 2903 | 230252 | 81044 | 29638279 |
Laboratory test abnormal | 1908.18 | 14.07 | 1358 | 231797 | 16084 | 29703239 |
Platelet count decreased | 1781.10 | 14.07 | 3058 | 230097 | 103071 | 29616252 |
Adverse drug reaction | 1705.48 | 14.07 | 1425 | 231730 | 21720 | 29697603 |
Unevaluable event | 1530.50 | 14.07 | 1542 | 231613 | 30243 | 29689080 |
Rash | 1497.58 | 14.07 | 4050 | 229105 | 187839 | 29531484 |
Fatigue | 1389.79 | 14.07 | 5536 | 227619 | 315137 | 29404186 |
Drug interaction | 1237.88 | 14.07 | 81 | 233074 | 199487 | 29519836 |
Deep vein thrombosis | 1026.83 | 14.07 | 1754 | 231401 | 58747 | 29660576 |
Off label use | 969.35 | 14.07 | 366 | 232789 | 248924 | 29470399 |
Myelodysplastic syndrome | 881.43 | 14.07 | 899 | 232256 | 17879 | 29701444 |
Plasma cell myeloma recurrent | 791.18 | 14.07 | 429 | 232726 | 2985 | 29716338 |
Constipation | 722.64 | 14.07 | 2223 | 230932 | 110683 | 29608640 |
Diarrhoea | 713.43 | 14.07 | 4736 | 228419 | 329367 | 29389956 |
Muscle spasms | 686.09 | 14.07 | 1541 | 231614 | 63297 | 29656026 |
Completed suicide | 626.11 | 14.07 | 37 | 233118 | 99455 | 29619868 |
Drug abuse | 615.43 | 14.07 | 4 | 233151 | 82068 | 29637255 |
Cardiac disorder | 595.53 | 14.07 | 1094 | 232061 | 38799 | 29680524 |
Tooth disorder | 569.02 | 14.07 | 512 | 232643 | 8649 | 29710674 |
Condition aggravated | 518.95 | 14.07 | 212 | 232943 | 137654 | 29581669 |
Overdose | 470.90 | 14.07 | 53 | 233102 | 84284 | 29635039 |
Neutropenia | 458.55 | 14.07 | 2098 | 231057 | 126442 | 29592881 |
Drug ineffective | 455.74 | 14.07 | 1262 | 231893 | 339125 | 29380198 |
Drug intolerance | 453.90 | 14.07 | 1054 | 232101 | 44237 | 29675086 |
Plasmacytoma | 434.32 | 14.07 | 290 | 232865 | 3066 | 29716257 |
Pancytopenia | 433.13 | 14.07 | 1551 | 231604 | 83501 | 29635822 |
Pulmonary thrombosis | 432.88 | 14.07 | 374 | 232781 | 5969 | 29713354 |
Squamous cell carcinoma of skin | 414.98 | 14.07 | 429 | 232726 | 8666 | 29710657 |
Renal disorder | 407.71 | 14.07 | 690 | 232465 | 22894 | 29696429 |
Influenza | 403.52 | 14.07 | 981 | 232174 | 42417 | 29676906 |
Peripheral swelling | 401.65 | 14.07 | 1215 | 231940 | 59859 | 29659464 |
Product dose omission issue | 401.13 | 14.07 | 1592 | 231563 | 90039 | 29629284 |
Pulmonary embolism | 385.15 | 14.07 | 1410 | 231745 | 76725 | 29642598 |
Ageusia | 379.42 | 14.07 | 406 | 232749 | 8547 | 29710776 |
COVID-19 | 355.05 | 14.07 | 557 | 232598 | 17321 | 29702002 |
Rash pruritic | 350.61 | 14.07 | 630 | 232525 | 21942 | 29697381 |
Red blood cell count decreased | 329.18 | 14.07 | 670 | 232485 | 25651 | 29693672 |
Blood count abnormal | 316.20 | 14.07 | 421 | 232734 | 11231 | 29708092 |
Product use in unapproved indication | 311.93 | 14.07 | 93 | 233062 | 73600 | 29645723 |
Neutrophil count decreased | 308.10 | 14.07 | 875 | 232280 | 41579 | 29677744 |
Intentional overdose | 306.08 | 14.07 | 3 | 233152 | 41478 | 29677845 |
Blood test abnormal | 304.70 | 14.07 | 289 | 232866 | 5236 | 29714087 |
Alanine aminotransferase increased | 303.20 | 14.07 | 100 | 233055 | 74176 | 29645147 |
Rhabdomyolysis | 298.36 | 14.07 | 65 | 233090 | 63515 | 29655808 |
Aspartate aminotransferase increased | 291.27 | 14.07 | 68 | 233087 | 63354 | 29655969 |
Acute kidney injury | 290.47 | 14.07 | 1124 | 232031 | 272718 | 29446605 |
Acute myeloid leukaemia | 282.74 | 14.07 | 505 | 232650 | 17501 | 29701822 |
Body height decreased | 276.98 | 14.07 | 231 | 232924 | 3503 | 29715820 |
Headache | 274.79 | 14.07 | 635 | 232520 | 181671 | 29537652 |
Rheumatoid arthritis | 266.22 | 14.07 | 13 | 233142 | 41184 | 29678139 |
Cytopenia | 264.55 | 14.07 | 324 | 232831 | 7932 | 29711391 |
Cataract | 263.80 | 14.07 | 548 | 232607 | 21287 | 29698036 |
Adult T-cell lymphoma/leukaemia | 262.93 | 14.07 | 93 | 233062 | 173 | 29719150 |
Thrombocytopenia | 252.90 | 14.07 | 1879 | 231276 | 135165 | 29584158 |
Taste disorder | 251.19 | 14.07 | 212 | 232943 | 3271 | 29716052 |
Blood creatine phosphokinase increased | 248.59 | 14.07 | 26 | 233129 | 43822 | 29675501 |
Asthenia | 248.19 | 14.07 | 2722 | 230433 | 218568 | 29500755 |
Seasonal allergy | 245.83 | 14.07 | 240 | 232915 | 4513 | 29714810 |
Intentional product misuse | 245.06 | 14.07 | 5 | 233150 | 34662 | 29684661 |
Back disorder | 242.03 | 14.07 | 265 | 232890 | 5729 | 29713594 |
Plasma cell leukaemia | 239.00 | 14.07 | 125 | 233030 | 800 | 29718523 |
Suicide attempt | 238.99 | 14.07 | 11 | 233144 | 36686 | 29682637 |
Hospitalisation | 237.11 | 14.07 | 32 | 233123 | 44287 | 29675036 |
Hypertension | 235.19 | 14.07 | 363 | 232792 | 120991 | 29598332 |
Vomiting | 234.92 | 14.07 | 899 | 232256 | 218919 | 29500404 |
Hyperkalaemia | 234.63 | 14.07 | 110 | 233045 | 65900 | 29653423 |
Tachycardia | 232.66 | 14.07 | 143 | 233012 | 73596 | 29645727 |
Light chain analysis increased | 227.52 | 14.07 | 125 | 233030 | 895 | 29718428 |
Hip fracture | 220.03 | 14.07 | 346 | 232809 | 10778 | 29708545 |
Hypoglycaemia | 218.14 | 14.07 | 63 | 233092 | 50918 | 29668405 |
Abdominal pain | 217.82 | 14.07 | 456 | 232699 | 135198 | 29584125 |
Full blood count increased | 214.89 | 14.07 | 112 | 233043 | 711 | 29718612 |
Mantle cell lymphoma | 206.25 | 14.07 | 136 | 233019 | 1405 | 29717918 |
Bradycardia | 201.30 | 14.07 | 131 | 233024 | 65395 | 29653928 |
Injection site pain | 197.65 | 14.07 | 9 | 233146 | 30301 | 29689022 |
Wrong technique in product usage process | 197.61 | 14.07 | 11 | 233144 | 31144 | 29688179 |
Multiple allergies | 196.17 | 14.07 | 150 | 233005 | 1993 | 29717330 |
Infection | 195.02 | 14.07 | 1155 | 232000 | 76919 | 29642404 |
Hiccups | 192.95 | 14.07 | 298 | 232857 | 9136 | 29710187 |
Gallbladder disorder | 192.44 | 14.07 | 233 | 232922 | 5634 | 29713689 |
Depressed level of consciousness | 192.11 | 14.07 | 33 | 233122 | 38189 | 29681134 |
Diffuse large B-cell lymphoma | 191.12 | 14.07 | 269 | 232886 | 7572 | 29711751 |
Intentional product use issue | 190.96 | 14.07 | 28 | 233127 | 36412 | 29682911 |
Psoriasis | 190.38 | 14.07 | 48 | 233107 | 42458 | 29676865 |
Hyponatraemia | 183.55 | 14.07 | 152 | 233003 | 67050 | 29652273 |
Agitation | 183.24 | 14.07 | 96 | 233059 | 53977 | 29665346 |
Monoclonal immunoglobulin present | 182.72 | 14.07 | 104 | 233051 | 804 | 29718519 |
Protein total increased | 181.73 | 14.07 | 143 | 233012 | 1987 | 29717336 |
Haemoglobin decreased | 176.65 | 14.07 | 1503 | 231652 | 112595 | 29606728 |
Suicidal ideation | 173.33 | 14.07 | 35 | 233120 | 36079 | 29683244 |
Coma | 173.01 | 14.07 | 50 | 233105 | 40399 | 29678924 |
Seizure | 172.74 | 14.07 | 314 | 232841 | 98161 | 29621162 |
Inappropriate schedule of product administration | 171.97 | 14.07 | 48 | 233107 | 39680 | 29679643 |
Aggression | 168.56 | 14.07 | 40 | 233115 | 36867 | 29682456 |
Lactic acidosis | 165.85 | 14.07 | 23 | 233132 | 31190 | 29688133 |
Blood pressure increased | 164.85 | 14.07 | 190 | 232965 | 71738 | 29647585 |
Herpes zoster | 162.43 | 14.07 | 558 | 232597 | 29385 | 29689938 |
Arthropathy | 161.93 | 14.07 | 439 | 232716 | 20288 | 29699035 |
Blood potassium decreased | 161.56 | 14.07 | 383 | 232772 | 16279 | 29703044 |
Metabolic acidosis | 157.13 | 14.07 | 48 | 233107 | 37413 | 29681910 |
Interstitial lung disease | 156.09 | 14.07 | 143 | 233012 | 60054 | 29659269 |
C-reactive protein increased | 155.13 | 14.07 | 72 | 233083 | 43401 | 29675922 |
Cardio-respiratory arrest | 153.56 | 14.07 | 132 | 233023 | 57174 | 29662149 |
Spinal fracture | 153.46 | 14.07 | 224 | 232931 | 6524 | 29712799 |
Gastric disorder | 150.72 | 14.07 | 284 | 232871 | 10259 | 29709064 |
Dry skin | 148.62 | 14.07 | 448 | 232707 | 22006 | 29697317 |
Basal cell carcinoma | 147.90 | 14.07 | 362 | 232793 | 15706 | 29703617 |
Renal failure | 146.26 | 14.07 | 1591 | 231564 | 127375 | 29591948 |
Skin cancer | 145.64 | 14.07 | 239 | 232916 | 7722 | 29711601 |
Product use issue | 141.29 | 14.07 | 92 | 233063 | 45924 | 29673399 |
Electrocardiogram QT prolonged | 139.71 | 14.07 | 52 | 233103 | 35783 | 29683540 |
Nasopharyngitis | 136.98 | 14.07 | 855 | 232300 | 57994 | 29661329 |
Ascites | 136.93 | 14.07 | 54 | 233101 | 35867 | 29683456 |
Bronchitis | 130.53 | 14.07 | 627 | 232528 | 38498 | 29680825 |
Drug level increased | 124.61 | 14.07 | 4 | 233151 | 18350 | 29700973 |
Hepatocellular injury | 123.66 | 14.07 | 24 | 233131 | 25447 | 29693876 |
Gamma-glutamyltransferase increased | 122.38 | 14.07 | 38 | 233117 | 29312 | 29690011 |
Myelodysplastic syndrome transformation | 121.33 | 14.07 | 61 | 233094 | 355 | 29718968 |
Respiratory arrest | 118.25 | 14.07 | 40 | 233115 | 29218 | 29690105 |
Hernia | 118.03 | 14.07 | 229 | 232926 | 8457 | 29710866 |
Product quality issue | 117.91 | 14.07 | 7 | 233148 | 18767 | 29700556 |
Skin discolouration | 117.88 | 14.07 | 329 | 232826 | 15465 | 29703858 |
Oxygen saturation decreased | 117.66 | 14.07 | 99 | 233056 | 43341 | 29675982 |
Depression | 117.54 | 14.07 | 339 | 232816 | 90098 | 29629225 |
Blood alkaline phosphatase increased | 117.30 | 14.07 | 49 | 233106 | 31438 | 29687885 |
Pruritus | 117.25 | 14.07 | 1421 | 231734 | 116783 | 29602540 |
Therapeutic product effect incomplete | 116.19 | 14.07 | 59 | 233096 | 33775 | 29685548 |
International normalised ratio increased | 116.10 | 14.07 | 120 | 233035 | 47619 | 29671704 |
Incorrect dose administered | 115.35 | 14.07 | 51 | 233104 | 31635 | 29687688 |
Anaphylactic reaction | 113.54 | 14.07 | 38 | 233117 | 27944 | 29691379 |
Abnormal behaviour | 112.68 | 14.07 | 30 | 233125 | 25593 | 29693730 |
Melaena | 112.24 | 14.07 | 56 | 233099 | 32381 | 29686942 |
Swelling face | 110.51 | 14.07 | 390 | 232765 | 20814 | 29698509 |
Fall | 109.57 | 14.07 | 2006 | 231149 | 179866 | 29539457 |
Localised infection | 109.35 | 14.07 | 293 | 232862 | 13444 | 29705879 |
Spinal disorder | 108.69 | 14.07 | 133 | 233022 | 3252 | 29716071 |
Hypercalcaemia | 108.15 | 14.07 | 275 | 232880 | 12220 | 29707103 |
SARS-CoV-2 test positive | 107.35 | 14.07 | 94 | 233061 | 1528 | 29717795 |
Hypoaesthesia | 106.91 | 14.07 | 756 | 232399 | 53474 | 29665849 |
Dysarthria | 106.46 | 14.07 | 52 | 233103 | 30438 | 29688885 |
Hepatic function abnormal | 105.94 | 14.07 | 102 | 233053 | 41843 | 29677480 |
Medication error | 105.61 | 14.07 | 18 | 233137 | 20954 | 29698369 |
Disease progression | 105.52 | 14.07 | 1017 | 232138 | 78857 | 29640466 |
Somnolence | 104.18 | 14.07 | 394 | 232761 | 96369 | 29622954 |
Adenocarcinoma of colon | 103.53 | 14.07 | 128 | 233027 | 3164 | 29716159 |
Amyloidosis | 103.19 | 14.07 | 104 | 233051 | 2035 | 29717288 |
Sedation | 103.15 | 14.07 | 6 | 233149 | 16367 | 29702956 |
Cholestasis | 102.78 | 14.07 | 33 | 233122 | 24917 | 29694406 |
Tumour flare | 102.72 | 14.07 | 59 | 233096 | 465 | 29718858 |
Acute leukaemia | 102.67 | 14.07 | 79 | 233076 | 1060 | 29718263 |
Angioedema | 102.52 | 14.07 | 71 | 233084 | 34313 | 29685010 |
Generalised tonic-clonic seizure | 102.47 | 14.07 | 15 | 233140 | 19536 | 29699787 |
Haematuria | 102.07 | 14.07 | 119 | 233036 | 44715 | 29674608 |
Blood urea increased | 101.52 | 14.07 | 59 | 233096 | 31322 | 29688001 |
Compression fracture | 100.79 | 14.07 | 120 | 233035 | 2849 | 29716474 |
Immune system disorder | 100.20 | 14.07 | 144 | 233011 | 4133 | 29715190 |
Product prescribing error | 99.96 | 14.07 | 8 | 233147 | 16725 | 29702598 |
Upper limb fracture | 99.89 | 14.07 | 141 | 233014 | 3979 | 29715344 |
Lactose intolerance | 99.32 | 14.07 | 69 | 233086 | 782 | 29718541 |
Blood bilirubin increased | 97.38 | 14.07 | 85 | 233070 | 36551 | 29682772 |
Musculoskeletal disorder | 96.57 | 14.07 | 152 | 233003 | 4737 | 29714586 |
Hypoacusis | 96.29 | 14.07 | 285 | 232870 | 13854 | 29705469 |
5q minus syndrome | 95.87 | 14.07 | 39 | 233116 | 124 | 29719199 |
Psychotic disorder | 94.97 | 14.07 | 25 | 233130 | 21490 | 29697833 |
Gastrointestinal haemorrhage | 94.95 | 14.07 | 332 | 232823 | 83114 | 29636209 |
Rib fracture | 93.97 | 14.07 | 264 | 232891 | 12456 | 29706867 |
Mucosal inflammation | 93.55 | 14.07 | 61 | 233094 | 30433 | 29688890 |
Hallucination, visual | 92.75 | 14.07 | 9 | 233146 | 16104 | 29703219 |
Atrial fibrillation | 92.47 | 14.07 | 1265 | 231890 | 106859 | 29612464 |
Drug-induced liver injury | 91.50 | 14.07 | 26 | 233129 | 21248 | 29698075 |
Hallucination | 90.90 | 14.07 | 151 | 233004 | 48908 | 29670415 |
Emotional distress | 90.23 | 14.07 | 9 | 233146 | 15756 | 29703567 |
Shock | 89.38 | 14.07 | 33 | 233122 | 22826 | 29696497 |
Eye disorder | 88.61 | 14.07 | 190 | 232965 | 7544 | 29711779 |
Epilepsy | 87.96 | 14.07 | 24 | 233131 | 20145 | 29699178 |
Drug hypersensitivity | 87.43 | 14.07 | 259 | 232896 | 68260 | 29651063 |
Cardiac arrest | 86.93 | 14.07 | 399 | 232756 | 92451 | 29626872 |
Transaminases increased | 86.57 | 14.07 | 37 | 233118 | 23420 | 29695903 |
Pallor | 86.42 | 14.07 | 28 | 233127 | 21021 | 29698302 |
Wheezing | 85.64 | 14.07 | 69 | 233086 | 30869 | 29688454 |
Anxiety | 85.45 | 14.07 | 384 | 232771 | 89487 | 29629836 |
Accidental overdose | 85.04 | 14.07 | 19 | 233136 | 18256 | 29701067 |
Erythema | 84.24 | 14.07 | 314 | 232841 | 77137 | 29642186 |
Leukocytosis | 84.14 | 14.07 | 31 | 233124 | 21471 | 29697852 |
Drug resistance | 84.05 | 14.07 | 26 | 233129 | 20107 | 29699216 |
Myoclonus | 83.49 | 14.07 | 5 | 233150 | 13307 | 29706016 |
Dehydration | 83.40 | 14.07 | 1388 | 231767 | 122151 | 29597172 |
Blood calcium increased | 82.90 | 14.07 | 111 | 233044 | 2976 | 29716347 |
Hepatic failure | 82.28 | 14.07 | 86 | 233069 | 33957 | 29685366 |
Agranulocytosis | 81.96 | 14.07 | 34 | 233121 | 21908 | 29697415 |
Bone pain | 81.77 | 14.07 | 329 | 232826 | 18697 | 29700626 |
Dysgeusia | 81.65 | 14.07 | 396 | 232759 | 24405 | 29694918 |
Dyskinesia | 81.29 | 14.07 | 34 | 233121 | 21800 | 29697523 |
Upper gastrointestinal haemorrhage | 80.89 | 14.07 | 35 | 233120 | 21993 | 29697330 |
Pregnancy of partner | 80.79 | 14.07 | 42 | 233113 | 265 | 29719058 |
Pancreatitis acute | 80.74 | 14.07 | 50 | 233105 | 25645 | 29693678 |
Back pain | 80.37 | 14.07 | 1182 | 231973 | 101414 | 29617909 |
Spinal compression fracture | 78.25 | 14.07 | 159 | 232996 | 6075 | 29713248 |
Sepsis | 77.95 | 14.07 | 1585 | 231570 | 144810 | 29574513 |
Prostatic disorder | 77.86 | 14.07 | 102 | 233053 | 2676 | 29716647 |
Diabetic ketoacidosis | 77.73 | 14.07 | 15 | 233140 | 15971 | 29703352 |
Pancreatitis | 77.65 | 14.07 | 102 | 233053 | 36388 | 29682935 |
Delirium | 76.25 | 14.07 | 124 | 233031 | 40507 | 29678816 |
Pathological fracture | 75.65 | 14.07 | 124 | 233031 | 4002 | 29715321 |
Unresponsive to stimuli | 75.56 | 14.07 | 57 | 233098 | 26362 | 29692961 |
Peritonitis bacterial | 75.43 | 14.07 | 3 | 233152 | 11375 | 29707948 |
Underdose | 74.83 | 14.07 | 5 | 233150 | 12136 | 29707187 |
Gout | 73.28 | 14.07 | 298 | 232857 | 17017 | 29702306 |
Jaundice | 73.11 | 14.07 | 87 | 233068 | 32399 | 29686924 |
Gastrointestinal disorder | 72.56 | 14.07 | 420 | 232735 | 27717 | 29691606 |
Sinus tachycardia | 72.38 | 14.07 | 16 | 233139 | 15488 | 29703835 |
Asthma | 72.09 | 14.07 | 106 | 233049 | 36068 | 29683255 |
Incorrect route of product administration | 71.73 | 14.07 | 4 | 233151 | 11311 | 29708012 |
Encephalopathy | 71.67 | 14.07 | 87 | 233068 | 32118 | 29687205 |
Coronary artery disease | 71.61 | 14.07 | 177 | 232978 | 49535 | 29669788 |
Hypoxia | 70.02 | 14.07 | 169 | 232986 | 47685 | 29671638 |
General physical health deterioration | 69.81 | 14.07 | 473 | 232682 | 99471 | 29619852 |
Tubulointerstitial nephritis | 69.66 | 14.07 | 26 | 233129 | 17865 | 29701458 |
Joint swelling | 69.66 | 14.07 | 613 | 232542 | 46333 | 29672990 |
Cerebral infarction | 69.10 | 14.07 | 62 | 233093 | 26311 | 29693012 |
Leukaemia | 68.61 | 14.07 | 105 | 233050 | 3192 | 29716131 |
Anaphylactic shock | 68.31 | 14.07 | 13 | 233142 | 13980 | 29705343 |
Palpitations | 68.26 | 14.07 | 97 | 233058 | 33476 | 29685847 |
White blood cell count increased | 68.16 | 14.07 | 128 | 233027 | 39545 | 29679778 |
Fear | 68.09 | 14.07 | 4 | 233151 | 10821 | 29708502 |
Blood pressure systolic increased | 67.76 | 14.07 | 17 | 233138 | 15093 | 29704230 |
Respiratory depression | 67.34 | 14.07 | 6 | 233149 | 11497 | 29707826 |
Malignant melanoma | 67.16 | 14.07 | 166 | 232989 | 7245 | 29712078 |
Acute lymphocytic leukaemia | 67 | 14.07 | 100 | 233055 | 2972 | 29716351 |
Blood creatinine increased | 66.05 | 14.07 | 428 | 232727 | 90947 | 29628376 |
Mobility decreased | 65.90 | 14.07 | 63 | 233092 | 25936 | 29693387 |
Arthralgia | 65.54 | 14.07 | 708 | 232447 | 135083 | 29584240 |
Vitamin D decreased | 65.05 | 14.07 | 91 | 233064 | 2546 | 29716777 |
Malignant neoplasm of unknown primary site | 65.02 | 14.07 | 39 | 233116 | 336 | 29718987 |
Hepatitis | 64.23 | 14.07 | 48 | 233107 | 22308 | 29697015 |
Multiple organ dysfunction syndrome | 64.16 | 14.07 | 265 | 232890 | 63222 | 29656101 |
Cardiac amyloidosis | 64.08 | 14.07 | 51 | 233104 | 721 | 29718602 |
Circulatory collapse | 63.98 | 14.07 | 39 | 233116 | 20175 | 29699148 |
Myalgia | 63.96 | 14.07 | 343 | 232812 | 76324 | 29642999 |
Confusional state | 63.88 | 14.07 | 706 | 232449 | 134128 | 29585195 |
Bone disorder | 63.23 | 14.07 | 153 | 233002 | 6588 | 29712735 |
Anaemia | 63.16 | 14.07 | 2090 | 231065 | 205902 | 29513421 |
Cyanosis | 62.91 | 14.07 | 9 | 233146 | 11926 | 29707397 |
Withdrawal syndrome | 62.90 | 14.07 | 7 | 233148 | 11243 | 29708080 |
Palmar-plantar erythrodysaesthesia syndrome | 62.44 | 14.07 | 19 | 233136 | 14851 | 29704472 |
Nausea | 62.39 | 14.07 | 1798 | 231357 | 295159 | 29424164 |
Altered state of consciousness | 62.25 | 14.07 | 39 | 233116 | 19880 | 29699443 |
Hepatic encephalopathy | 61.68 | 14.07 | 17 | 233138 | 14175 | 29705148 |
Brain oedema | 61.64 | 14.07 | 11 | 233144 | 12387 | 29706936 |
Status epilepticus | 61.63 | 14.07 | 7 | 233148 | 11065 | 29708258 |
Ventricular tachycardia | 61.45 | 14.07 | 57 | 233098 | 23805 | 29695518 |
Colitis ulcerative | 61.41 | 14.07 | 18 | 233137 | 14416 | 29704907 |
Sinus disorder | 61.31 | 14.07 | 144 | 233011 | 6081 | 29713242 |
Increased tendency to bruise | 60.82 | 14.07 | 104 | 233051 | 3477 | 29715846 |
Paranoia | 60.50 | 14.07 | 5 | 233150 | 10183 | 29709140 |
Liver function test abnormal | 60.40 | 14.07 | 92 | 233063 | 30858 | 29688465 |
Drug ineffective for unapproved indication | 60.25 | 14.07 | 7 | 233148 | 10873 | 29708450 |
Haematemesis | 60.22 | 14.07 | 69 | 233086 | 26134 | 29693189 |
Bone lesion | 60.12 | 14.07 | 88 | 233067 | 2569 | 29716754 |
Neutrophil count increased | 60.11 | 14.07 | 22 | 233133 | 15301 | 29704022 |
Blood lactate dehydrogenase increased | 59.49 | 14.07 | 44 | 233111 | 20557 | 29698766 |
White blood cell count abnormal | 59.39 | 14.07 | 88 | 233067 | 2598 | 29716725 |
Cytomegalovirus infection | 59.27 | 14.07 | 58 | 233097 | 23616 | 29695707 |
Renal injury | 59.20 | 14.07 | 10 | 233145 | 11719 | 29707604 |
Transplant rejection | 59.15 | 14.07 | 3 | 233152 | 9203 | 29710120 |
Hypokalaemia | 58.21 | 14.07 | 198 | 232957 | 49994 | 29669329 |
Obstructive airways disorder | 58.06 | 14.07 | 3 | 233152 | 9056 | 29710267 |
Hypotension | 57.90 | 14.07 | 1157 | 231998 | 199408 | 29519915 |
Arteriosclerosis coronary artery | 57.59 | 14.07 | 9 | 233146 | 11167 | 29708156 |
Hepatotoxicity | 57.44 | 14.07 | 35 | 233120 | 18110 | 29701213 |
Adverse event | 57.15 | 14.07 | 254 | 232901 | 15087 | 29704236 |
Respiratory distress | 56.97 | 14.07 | 106 | 233049 | 32866 | 29686457 |
Blood triglycerides increased | 56.92 | 14.07 | 19 | 233136 | 13998 | 29705325 |
Illness | 56.39 | 14.07 | 96 | 233059 | 3198 | 29716125 |
Hyperlipidaemia | 56.21 | 14.07 | 19 | 233136 | 13888 | 29705435 |
Osteonecrosis of jaw | 56.13 | 14.07 | 290 | 232865 | 18328 | 29700995 |
Surgery | 55.82 | 14.07 | 11 | 233144 | 11540 | 29707783 |
Hemiparesis | 55.18 | 14.07 | 23 | 233132 | 14779 | 29704544 |
Delusion | 54.71 | 14.07 | 13 | 233142 | 11976 | 29707347 |
Chronic lymphocytic leukaemia | 54.52 | 14.07 | 115 | 233040 | 4513 | 29714810 |
Tachypnoea | 54.51 | 14.07 | 24 | 233131 | 14928 | 29704395 |
Hypogeusia | 54.13 | 14.07 | 48 | 233107 | 794 | 29718529 |
Injection site erythema | 54.03 | 14.07 | 20 | 233135 | 13814 | 29705509 |
Hyperhidrosis | 53.85 | 14.07 | 304 | 232851 | 66786 | 29652537 |
Malignant neoplasm progression | 53.55 | 14.07 | 336 | 232819 | 71951 | 29647372 |
Chest discomfort | 53.02 | 14.07 | 179 | 232976 | 45301 | 29674022 |
Injection site swelling | 53.00 | 14.07 | 4 | 233151 | 8776 | 29710547 |
Coagulopathy | 52.72 | 14.07 | 40 | 233115 | 18447 | 29700876 |
Product administration error | 52.54 | 14.07 | 23 | 233132 | 14354 | 29704969 |
Restlessness | 52.49 | 14.07 | 59 | 233096 | 22540 | 29696783 |
Disseminated intravascular coagulation | 52.47 | 14.07 | 57 | 233098 | 22114 | 29697209 |
Treatment noncompliance | 52.29 | 14.07 | 72 | 233083 | 25181 | 29694142 |
Acute myocardial infarction | 52.23 | 14.07 | 223 | 232932 | 52716 | 29666607 |
Hordeolum | 52.06 | 14.07 | 44 | 233111 | 680 | 29718643 |
Hepatic steatosis | 51.98 | 14.07 | 25 | 233130 | 14768 | 29704555 |
Dysphonia | 51.64 | 14.07 | 288 | 232867 | 18744 | 29700579 |
Cardiogenic shock | 51.34 | 14.07 | 34 | 233121 | 16827 | 29702496 |
Fluid retention | 51.29 | 14.07 | 352 | 232803 | 24646 | 29694677 |
Angina unstable | 51.20 | 14.07 | 16 | 233139 | 12294 | 29707029 |
Exposure during pregnancy | 51.18 | 14.07 | 6 | 233149 | 9255 | 29710068 |
Vitamin B12 decreased | 50.88 | 14.07 | 51 | 233104 | 991 | 29718332 |
Accidental exposure to product | 50.23 | 14.07 | 9 | 233146 | 10106 | 29709217 |
Injury | 50.18 | 14.07 | 57 | 233098 | 21674 | 29697649 |
Synovitis | 50.14 | 14.07 | 8 | 233147 | 9775 | 29709548 |
Thrombophlebitis superficial | 50.00 | 14.07 | 81 | 233074 | 2588 | 29716735 |
Drug reaction with eosinophilia and systemic symptoms | 49.74 | 14.07 | 91 | 233064 | 28397 | 29690926 |
Pulmonary hypertension | 49.57 | 14.07 | 45 | 233110 | 18991 | 29700332 |
Light chain analysis abnormal | 49.56 | 14.07 | 19 | 233136 | 49 | 29719274 |
Respiratory failure | 49.23 | 14.07 | 523 | 232632 | 100119 | 29619204 |
Angina pectoris | 49.16 | 14.07 | 97 | 233058 | 29421 | 29689902 |
Diabetes mellitus inadequate control | 48.93 | 14.07 | 19 | 233136 | 12743 | 29706580 |
Renal tubular necrosis | 48.86 | 14.07 | 29 | 233126 | 15222 | 29704101 |
Dementia | 48.46 | 14.07 | 209 | 232946 | 12252 | 29707071 |
Depressed mood | 48.36 | 14.07 | 37 | 233118 | 16992 | 29702331 |
Ventricular fibrillation | 48.20 | 14.07 | 29 | 233126 | 15109 | 29704214 |
Chest pain | 48.03 | 14.07 | 636 | 232519 | 116991 | 29602332 |
Myositis | 47.86 | 14.07 | 11 | 233144 | 10366 | 29708957 |
Platelet disorder | 47.56 | 14.07 | 53 | 233102 | 1169 | 29718154 |
Rectal haemorrhage | 47.55 | 14.07 | 128 | 233027 | 34811 | 29684512 |
Acute respiratory distress syndrome | 47.53 | 14.07 | 68 | 233087 | 23404 | 29695919 |
Peritonitis | 47.29 | 14.07 | 58 | 233097 | 21317 | 29698006 |
Schizophrenia | 47.28 | 14.07 | 7 | 233148 | 9041 | 29710282 |
Inappropriate antidiuretic hormone secretion | 47.23 | 14.07 | 15 | 233140 | 11407 | 29707916 |
Lipase increased | 47.02 | 14.07 | 6 | 233149 | 8670 | 29710653 |
Pulmonary arterial hypertension | 46.79 | 14.07 | 8 | 233147 | 9293 | 29710030 |
Dry eye | 46.56 | 14.07 | 133 | 233022 | 6335 | 29712988 |
Hepatitis cholestatic | 46.37 | 14.07 | 4 | 233151 | 7868 | 29711455 |
Sleep apnoea syndrome | 46.14 | 14.07 | 38 | 233117 | 16819 | 29702504 |
Coronavirus infection | 46.04 | 14.07 | 91 | 233064 | 3407 | 29715916 |
Blood pressure decreased | 46.01 | 14.07 | 199 | 232956 | 46876 | 29672447 |
Nerve injury | 45.96 | 14.07 | 83 | 233072 | 2900 | 29716423 |
Cardiomegaly | 45.91 | 14.07 | 28 | 233127 | 14481 | 29704842 |
Stress | 45.73 | 14.07 | 54 | 233101 | 20181 | 29699142 |
Dystonia | 45.48 | 14.07 | 10 | 233145 | 9717 | 29709606 |
Acidosis | 45.40 | 14.07 | 12 | 233143 | 10289 | 29709034 |
Pathogen resistance | 45.13 | 14.07 | 6 | 233149 | 8404 | 29710919 |
Lymphoma | 45.08 | 14.07 | 177 | 232978 | 9944 | 29709379 |
Loss of personal independence in daily activities | 44.99 | 14.07 | 61 | 233094 | 21474 | 29697849 |
Lower limb fracture | 44.84 | 14.07 | 93 | 233062 | 3606 | 29715717 |
Hypomagnesaemia | 44.72 | 14.07 | 38 | 233117 | 16560 | 29702763 |
Hepatic enzyme increased | 44.61 | 14.07 | 124 | 233031 | 33370 | 29685953 |
Pneumonia aspiration | 44.51 | 14.07 | 148 | 233007 | 37632 | 29681691 |
Hyperbilirubinaemia | 44.18 | 14.07 | 40 | 233115 | 16902 | 29702421 |
Haematoma | 44.10 | 14.07 | 74 | 233081 | 23879 | 29695444 |
Kidney transplant rejection | 43.73 | 14.07 | 4 | 233151 | 7505 | 29711818 |
Infusion related reaction | 43.72 | 14.07 | 165 | 232990 | 40399 | 29678924 |
Toxic epidermal necrolysis | 43.71 | 14.07 | 45 | 233110 | 17895 | 29701428 |
Blood pressure fluctuation | 43.68 | 14.07 | 43 | 233112 | 17460 | 29701863 |
Anuria | 43.64 | 14.07 | 13 | 233142 | 10303 | 29709020 |
Cerebral haemorrhage | 43.62 | 14.07 | 122 | 233033 | 32765 | 29686558 |
Clostridium difficile infection | 43.59 | 14.07 | 240 | 232915 | 15543 | 29703780 |
Protein total abnormal | 43.15 | 14.07 | 29 | 233126 | 310 | 29719013 |
Balance disorder | 43.00 | 14.07 | 454 | 232701 | 36039 | 29683284 |
Duodenal ulcer | 42.76 | 14.07 | 12 | 233143 | 9889 | 29709434 |
Monoclonal immunoglobulin increased | 42.65 | 14.07 | 16 | 233139 | 38 | 29719285 |
Hepatic cirrhosis | 42.65 | 14.07 | 37 | 233118 | 15962 | 29703361 |
Anhedonia | 42.54 | 14.07 | 7 | 233148 | 8362 | 29710961 |
Flushing | 42.47 | 14.07 | 105 | 233050 | 29387 | 29689936 |
Haemodynamic instability | 42.35 | 14.07 | 6 | 233149 | 8009 | 29711314 |
Weight fluctuation | 42.24 | 14.07 | 92 | 233063 | 3692 | 29715631 |
Hyperthermia | 42.23 | 14.07 | 13 | 233142 | 10086 | 29709237 |
No adverse event | 42.09 | 14.07 | 44 | 233111 | 17375 | 29701948 |
Aphasia | 41.70 | 14.07 | 54 | 233101 | 19385 | 29699938 |
Full blood count abnormal | 41.60 | 14.07 | 47 | 233108 | 1053 | 29718270 |
Treatment failure | 41.44 | 14.07 | 135 | 233020 | 34544 | 29684779 |
Torsade de pointes | 41.42 | 14.07 | 4 | 233151 | 7186 | 29712137 |
Gastritis | 41.41 | 14.07 | 58 | 233097 | 20140 | 29699183 |
Injection site haemorrhage | 41.22 | 14.07 | 6 | 233149 | 7849 | 29711474 |
Decreased appetite | 41.07 | 14.07 | 1489 | 231666 | 148421 | 29570902 |
Hepatitis C | 41.06 | 14.07 | 26 | 233129 | 13179 | 29706144 |
Proteinuria | 41.06 | 14.07 | 39 | 233116 | 16106 | 29703217 |
Device malfunction | 40.75 | 14.07 | 7 | 233148 | 8104 | 29711219 |
Shock haemorrhagic | 40.71 | 14.07 | 13 | 233142 | 9852 | 29709471 |
Oliguria | 40.67 | 14.07 | 5 | 233150 | 7434 | 29711889 |
Adverse reaction | 40.48 | 14.07 | 77 | 233078 | 2801 | 29716522 |
Speech disorder | 40.43 | 14.07 | 81 | 233074 | 24431 | 29694892 |
Blood iron decreased | 40.38 | 14.07 | 94 | 233061 | 3946 | 29715377 |
Haemodialysis | 40.01 | 14.07 | 18 | 233137 | 11055 | 29708268 |
Venoocclusive liver disease | 39.95 | 14.07 | 3 | 233152 | 6610 | 29712713 |
Injection site bruising | 39.95 | 14.07 | 5 | 233150 | 7333 | 29711990 |
Blood loss anaemia | 39.62 | 14.07 | 6 | 233149 | 7621 | 29711702 |
Obesity | 39.59 | 14.07 | 9 | 233146 | 8546 | 29710777 |
Neurotoxicity | 39.58 | 14.07 | 27 | 233128 | 13155 | 29706168 |
B-cell type acute leukaemia | 39.56 | 14.07 | 26 | 233129 | 267 | 29719056 |
Hypercholesterolaemia | 39.38 | 14.07 | 6 | 233149 | 7586 | 29711737 |
Skin exfoliation | 39.38 | 14.07 | 312 | 232843 | 22860 | 29696463 |
Metastases to bone | 39.37 | 14.07 | 13 | 233142 | 9645 | 29709678 |
Myocardial ischaemia | 39.36 | 14.07 | 46 | 233109 | 17271 | 29702052 |
Metastases to lung | 39.26 | 14.07 | 7 | 233148 | 7888 | 29711435 |
Disturbance in attention | 39.24 | 14.07 | 70 | 233085 | 22059 | 29697264 |
Blood albumin decreased | 38.87 | 14.07 | 25 | 233130 | 12567 | 29706756 |
Inflammation | 38.77 | 14.07 | 70 | 233085 | 21956 | 29697367 |
Hallucination, auditory | 38.49 | 14.07 | 14 | 233141 | 9775 | 29709548 |
Swelling | 38.46 | 14.07 | 439 | 232716 | 35536 | 29683787 |
Basosquamous carcinoma of skin | 38.42 | 14.07 | 11 | 233144 | 5 | 29719318 |
Dysphagia | 38.24 | 14.07 | 271 | 232884 | 56427 | 29662896 |
Therapeutic response unexpected | 38.06 | 14.07 | 11 | 233144 | 8892 | 29710431 |
Metastases to liver | 37.98 | 14.07 | 23 | 233132 | 11942 | 29707381 |
Therapy non-responder | 37.85 | 14.07 | 373 | 232782 | 29080 | 29690243 |
Malignant melanoma in situ | 37.31 | 14.07 | 42 | 233113 | 937 | 29718386 |
Glomerular filtration rate decreased | 37.26 | 14.07 | 21 | 233134 | 11341 | 29707982 |
Osteolysis | 37.24 | 14.07 | 53 | 233102 | 1507 | 29717816 |
Acute hepatic failure | 37.17 | 14.07 | 23 | 233132 | 11804 | 29707519 |
Hypothermia | 37.08 | 14.07 | 14 | 233141 | 9553 | 29709770 |
Posterior reversible encephalopathy syndrome | 36.78 | 14.07 | 11 | 233144 | 8696 | 29710627 |
Hypertriglyceridaemia | 36.52 | 14.07 | 9 | 233146 | 8089 | 29711234 |
Respiratory rate increased | 36.34 | 14.07 | 12 | 233143 | 8903 | 29710420 |
Hypertensive crisis | 36.33 | 14.07 | 10 | 233145 | 8347 | 29710976 |
Body temperature decreased | 35.99 | 14.07 | 15 | 233140 | 9640 | 29709683 |
Bronchospasm | 35.53 | 14.07 | 18 | 233137 | 10320 | 29709003 |
Chills | 35.32 | 14.07 | 376 | 232779 | 71962 | 29647361 |
Mitral valve incompetence | 34.80 | 14.07 | 31 | 233124 | 13203 | 29706120 |
Activated partial thromboplastin time prolonged | 34.73 | 14.07 | 9 | 233146 | 7819 | 29711504 |
Respiratory tract congestion | 34.68 | 14.07 | 108 | 233047 | 5398 | 29713925 |
Refractory anaemia with an excess of blasts | 34.68 | 14.07 | 27 | 233128 | 369 | 29718954 |
Mania | 34.48 | 14.07 | 14 | 233141 | 9140 | 29710183 |
Gynaecomastia | 34.47 | 14.07 | 11 | 233144 | 8340 | 29710983 |
Blood electrolytes decreased | 34.21 | 14.07 | 26 | 233129 | 342 | 29718981 |
Injection site reaction | 33.72 | 14.07 | 21 | 233134 | 10739 | 29708584 |
Weight decreased | 33.62 | 14.07 | 1466 | 231689 | 149455 | 29569868 |
White blood cell disorder | 33.59 | 14.07 | 45 | 233110 | 1207 | 29718116 |
Dyslipidaemia | 33.49 | 14.07 | 3 | 233152 | 5724 | 29713599 |
Product storage error | 33.27 | 14.07 | 5 | 233150 | 6386 | 29712937 |
Left ventricular dysfunction | 33.22 | 14.07 | 13 | 233142 | 8678 | 29710645 |
Coordination abnormal | 33.18 | 14.07 | 8 | 233147 | 7297 | 29712026 |
Haemorrhage intracranial | 33.03 | 14.07 | 41 | 233114 | 14991 | 29704332 |
Hypokinesia | 32.88 | 14.07 | 8 | 233147 | 7252 | 29712071 |
Rhinorrhoea | 32.86 | 14.07 | 275 | 232880 | 20479 | 29698844 |
Blood immunoglobulin G increased | 32.85 | 14.07 | 38 | 233117 | 874 | 29718449 |
Dyspnoea | 32.80 | 14.07 | 2195 | 230960 | 331100 | 29388223 |
B-cell lymphoma | 32.72 | 14.07 | 93 | 233062 | 4417 | 29714906 |
Liver injury | 32.66 | 14.07 | 29 | 233126 | 12371 | 29706952 |
Left ventricular hypertrophy | 32.48 | 14.07 | 5 | 233150 | 6273 | 29713050 |
Viral infection | 32.45 | 14.07 | 216 | 232939 | 14969 | 29704354 |
Feeling abnormal | 32.30 | 14.07 | 621 | 232534 | 56135 | 29663188 |
Lacrimation increased | 32.30 | 14.07 | 124 | 233031 | 6892 | 29712431 |
Type 2 diabetes mellitus | 32.25 | 14.07 | 35 | 233120 | 13587 | 29705736 |
Paraesthesia | 32.15 | 14.07 | 598 | 232557 | 53729 | 29665594 |
Pneumonia viral | 32.09 | 14.07 | 67 | 233088 | 2610 | 29716713 |
Tooth infection | 31.94 | 14.07 | 101 | 233054 | 5090 | 29714233 |
Hepatitis acute | 31.70 | 14.07 | 8 | 233147 | 7075 | 29712248 |
Oral disorder | 31.68 | 14.07 | 86 | 233069 | 3976 | 29715347 |
Uveitis | 31.68 | 14.07 | 3 | 233152 | 5474 | 29713849 |
Prostate cancer | 31.56 | 14.07 | 305 | 232850 | 23652 | 29695671 |
Post procedural complication | 31.40 | 14.07 | 27 | 233128 | 11699 | 29707624 |
Chondrocalcinosis pyrophosphate | 31.37 | 14.07 | 34 | 233121 | 726 | 29718597 |
Multiple sclerosis | 31.03 | 14.07 | 9 | 233146 | 7258 | 29712065 |
Disease recurrence | 30.72 | 14.07 | 39 | 233116 | 14122 | 29705201 |
Aphonia | 30.62 | 14.07 | 71 | 233084 | 2973 | 29716350 |
Memory impairment | 30.53 | 14.07 | 432 | 232723 | 36742 | 29682581 |
Hyperviscosity syndrome | 30.38 | 14.07 | 20 | 233135 | 206 | 29719117 |
Toothache | 30.37 | 14.07 | 107 | 233048 | 5704 | 29713619 |
Nephropathy toxic | 30.36 | 14.07 | 23 | 233132 | 10616 | 29708707 |
Impaired work ability | 30.35 | 14.07 | 4 | 233151 | 5639 | 29713684 |
Femur fracture | 30.29 | 14.07 | 125 | 233030 | 7184 | 29712139 |
Arteriosclerosis | 30.17 | 14.07 | 24 | 233131 | 10809 | 29708514 |
Urinary tract infection | 29.91 | 14.07 | 768 | 232387 | 72891 | 29646432 |
Cerebrovascular accident | 29.81 | 14.07 | 856 | 232299 | 82621 | 29636702 |
Dyspnoea exertional | 29.81 | 14.07 | 158 | 232997 | 35272 | 29684051 |
Viral upper respiratory tract infection | 29.77 | 14.07 | 65 | 233090 | 2613 | 29716710 |
Product dispensing error | 29.77 | 14.07 | 5 | 233150 | 5884 | 29713439 |
Hypovolaemic shock | 29.76 | 14.07 | 7 | 233148 | 6493 | 29712830 |
Tricuspid valve incompetence | 29.65 | 14.07 | 15 | 233140 | 8608 | 29710715 |
Blood calcium decreased | 29.56 | 14.07 | 150 | 233005 | 9412 | 29709911 |
Joint range of motion decreased | 29.46 | 14.07 | 5 | 233150 | 5840 | 29713483 |
Rectal adenocarcinoma | 29.43 | 14.07 | 34 | 233121 | 781 | 29718542 |
Limb discomfort | 29.41 | 14.07 | 144 | 233011 | 8906 | 29710417 |
Parkinsonism | 29.26 | 14.07 | 10 | 233145 | 7259 | 29712064 |
Epstein-Barr virus infection | 29.20 | 14.07 | 8 | 233147 | 6698 | 29712625 |
Limb injury | 29.18 | 14.07 | 143 | 233012 | 8848 | 29710475 |
Cardiac valve disease | 28.80 | 14.07 | 68 | 233087 | 2881 | 29716442 |
Upper respiratory tract infection | 28.79 | 14.07 | 334 | 232821 | 27142 | 29692181 |
Subarachnoid haemorrhage | 28.69 | 14.07 | 21 | 233134 | 9865 | 29709458 |
Pulmonary fibrosis | 28.41 | 14.07 | 50 | 233105 | 15840 | 29703483 |
Vertebral lesion | 28.39 | 14.07 | 17 | 233138 | 146 | 29719177 |
Tumour marker increased | 28.33 | 14.07 | 27 | 233128 | 492 | 29718831 |
Dermatitis allergic | 28.22 | 14.07 | 104 | 233051 | 5668 | 29713655 |
Prostate cancer stage II | 28.20 | 14.07 | 19 | 233136 | 204 | 29719119 |
Haemoptysis | 28.19 | 14.07 | 135 | 233020 | 30943 | 29688380 |
Hiatus hernia | 28.11 | 14.07 | 10 | 233145 | 7080 | 29712243 |
Auditory disorder | 28.01 | 14.07 | 17 | 233138 | 150 | 29719173 |
Granulocytopenia | 27.92 | 14.07 | 7 | 233148 | 6219 | 29713104 |
Crying | 27.83 | 14.07 | 5 | 233150 | 5604 | 29713719 |
Cardiac failure congestive | 27.83 | 14.07 | 857 | 232298 | 83550 | 29635773 |
Ejection fraction decreased | 27.82 | 14.07 | 47 | 233108 | 15128 | 29704195 |
Glycosylated haemoglobin increased | 27.75 | 14.07 | 20 | 233135 | 9471 | 29709852 |
Sinus bradycardia | 27.74 | 14.07 | 30 | 233125 | 11665 | 29707658 |
Iron deficiency anaemia | 27.74 | 14.07 | 18 | 233137 | 9006 | 29710317 |
Ataxia | 27.64 | 14.07 | 29 | 233126 | 11433 | 29707890 |
Disorientation | 27.62 | 14.07 | 138 | 233017 | 31280 | 29688043 |
Eosinophilia | 27.36 | 14.07 | 85 | 233070 | 22075 | 29697248 |
Blood lactic acid increased | 27.25 | 14.07 | 6 | 233149 | 5824 | 29713499 |
Cardiac failure | 27.17 | 14.07 | 471 | 232684 | 82947 | 29636376 |
Hepatomegaly | 27.07 | 14.07 | 23 | 233132 | 10024 | 29709299 |
Flatulence | 27.01 | 14.07 | 237 | 232918 | 17892 | 29701431 |
Myocarditis | 26.87 | 14.07 | 23 | 233132 | 9988 | 29709335 |
Skin sensitisation | 26.66 | 14.07 | 17 | 233138 | 165 | 29719158 |
POEMS syndrome | 26.58 | 14.07 | 10 | 233145 | 24 | 29719299 |
Asphyxia | 26.56 | 14.07 | 5 | 233150 | 5420 | 29713903 |
Nightmare | 26.47 | 14.07 | 33 | 233122 | 12043 | 29707280 |
Refractory cytopenia with multilineage dysplasia | 26.28 | 14.07 | 16 | 233139 | 142 | 29719181 |
Metastases to central nervous system | 26.07 | 14.07 | 12 | 233143 | 7272 | 29712051 |
Device dislocation | 26.04 | 14.07 | 4 | 233151 | 5027 | 29714296 |
Arthropod bite | 25.95 | 14.07 | 57 | 233098 | 2301 | 29717022 |
Knee arthroplasty | 25.90 | 14.07 | 6 | 233149 | 5624 | 29713699 |
Myelofibrosis | 25.86 | 14.07 | 45 | 233110 | 1526 | 29717797 |
Post transplant lymphoproliferative disorder | 25.75 | 14.07 | 5 | 233150 | 5301 | 29714022 |
Injection site pruritus | 25.64 | 14.07 | 6 | 233149 | 5586 | 29713737 |
Transfusion | 25.62 | 14.07 | 13 | 233142 | 7448 | 29711875 |
Sinusitis | 25.60 | 14.07 | 383 | 232772 | 32962 | 29686361 |
Visual acuity reduced | 25.59 | 14.07 | 53 | 233102 | 15793 | 29703530 |
Hypotonia | 25.57 | 14.07 | 11 | 233144 | 6937 | 29712386 |
Neuralgia | 25.54 | 14.07 | 154 | 233001 | 10312 | 29709011 |
Bronchopulmonary aspergillosis | 25.45 | 14.07 | 35 | 233120 | 12249 | 29707074 |
Sputum discoloured | 25.44 | 14.07 | 10 | 233145 | 6658 | 29712665 |
Subdural haematoma | 25.44 | 14.07 | 70 | 233085 | 18902 | 29700421 |
Breath sounds abnormal | 25.37 | 14.07 | 4 | 233151 | 4931 | 29714392 |
Lower gastrointestinal haemorrhage | 25.36 | 14.07 | 15 | 233140 | 7889 | 29711434 |
Gingival pain | 25.31 | 14.07 | 53 | 233102 | 2069 | 29717254 |
B precursor type acute leukaemia | 25.27 | 14.07 | 13 | 233142 | 80 | 29719243 |
Cytokine release syndrome | 25.25 | 14.07 | 24 | 233131 | 9909 | 29709414 |
Eye swelling | 25.22 | 14.07 | 137 | 233018 | 8827 | 29710496 |
Dialysis | 25.21 | 14.07 | 29 | 233126 | 10967 | 29708356 |
Fracture | 25.12 | 14.07 | 103 | 233052 | 5903 | 29713420 |
Papule | 25.10 | 14.07 | 67 | 233088 | 3066 | 29716257 |
Gait disturbance | 25.07 | 14.07 | 420 | 232735 | 74357 | 29644966 |
Cardiomyopathy | 25.01 | 14.07 | 50 | 233105 | 15093 | 29704230 |
Red blood cell count abnormal | 24.95 | 14.07 | 26 | 233129 | 530 | 29718793 |
Middle insomnia | 24.93 | 14.07 | 7 | 233148 | 5766 | 29713557 |
Coronary artery bypass | 24.77 | 14.07 | 5 | 233150 | 5157 | 29714166 |
Drug eruption | 24.76 | 14.07 | 63 | 233092 | 17463 | 29701860 |
Tendonitis | 24.74 | 14.07 | 16 | 233139 | 8020 | 29711303 |
Haemophagocytic lymphohistiocytosis | 24.49 | 14.07 | 24 | 233131 | 9767 | 29709556 |
Enterococcal infection | 24.48 | 14.07 | 17 | 233138 | 8207 | 29711116 |
Rales | 24.39 | 14.07 | 10 | 233145 | 6490 | 29712833 |
Osteoarthritis | 24.38 | 14.07 | 68 | 233087 | 18281 | 29701042 |
Dermatitis acneiform | 24.37 | 14.07 | 7 | 233148 | 5682 | 29713641 |
Blood pressure diastolic decreased | 24.35 | 14.07 | 9 | 233146 | 6222 | 29713101 |
Jaw disorder | 24.05 | 14.07 | 54 | 233101 | 2213 | 29717110 |
Oesophagitis | 23.99 | 14.07 | 31 | 233124 | 11140 | 29708183 |
Motor dysfunction | 23.96 | 14.07 | 8 | 233147 | 5894 | 29713429 |
Gastritis erosive | 23.88 | 14.07 | 7 | 233148 | 5606 | 29713717 |
Pelvic fracture | 23.87 | 14.07 | 53 | 233102 | 2155 | 29717168 |
Platelet count abnormal | 23.73 | 14.07 | 55 | 233100 | 2302 | 29717021 |
Renal tubular disorder | 23.70 | 14.07 | 5 | 233150 | 5001 | 29714322 |
Hydronephrosis | 23.67 | 14.07 | 21 | 233134 | 8962 | 29710361 |
Pseudomonas infection | 23.65 | 14.07 | 28 | 233127 | 10454 | 29708869 |
Atrial flutter | 23.56 | 14.07 | 191 | 232964 | 14090 | 29705233 |
Cholecystitis infective | 23.52 | 14.07 | 44 | 233111 | 1580 | 29717743 |
Parosmia | 23.42 | 14.07 | 40 | 233115 | 1336 | 29717987 |
Right ventricular failure | 23.41 | 14.07 | 17 | 233138 | 8019 | 29711304 |
Pneumonia influenzal | 23.41 | 14.07 | 39 | 233116 | 1276 | 29718047 |
Lentigo maligna | 23.36 | 14.07 | 18 | 233137 | 242 | 29719081 |
Oedema | 23.25 | 14.07 | 218 | 232937 | 42775 | 29676548 |
Vitamin B complex deficiency | 23.24 | 14.07 | 15 | 233140 | 149 | 29719174 |
Panic attack | 23.23 | 14.07 | 20 | 233135 | 8661 | 29710662 |
Gastrointestinal motility disorder | 23.19 | 14.07 | 53 | 233102 | 2198 | 29717125 |
Food poisoning | 23.18 | 14.07 | 37 | 233118 | 1167 | 29718156 |
Prothrombin time prolonged | 23.04 | 14.07 | 23 | 233132 | 9280 | 29710043 |
Stent placement | 23.01 | 14.07 | 4 | 233151 | 4592 | 29714731 |
Adenovirus infection | 23.01 | 14.07 | 3 | 233152 | 4265 | 29715058 |
Coronary artery stenosis | 22.96 | 14.07 | 22 | 233133 | 9048 | 29710275 |
Ventricular hypertrophy | 22.90 | 14.07 | 5 | 233150 | 4882 | 29714441 |
Necrosis | 22.89 | 14.07 | 6 | 233149 | 5173 | 29714150 |
Apnoea | 22.88 | 14.07 | 10 | 233145 | 6248 | 29713075 |
Eosinophil count increased | 22.85 | 14.07 | 15 | 233140 | 7458 | 29711865 |
Post procedural haemorrhage | 22.70 | 14.07 | 17 | 233138 | 7893 | 29711430 |
Clavicle fracture | 22.62 | 14.07 | 49 | 233106 | 1959 | 29717364 |
Blood immunoglobulin M increased | 22.55 | 14.07 | 16 | 233139 | 188 | 29719135 |
Adrenal insufficiency | 22.51 | 14.07 | 29 | 233126 | 10434 | 29708889 |
Ischaemia | 22.50 | 14.07 | 4 | 233151 | 4517 | 29714806 |
Acute respiratory failure | 22.46 | 14.07 | 114 | 233041 | 25736 | 29693587 |
Procedural pain | 22.42 | 14.07 | 6 | 233149 | 5103 | 29714220 |
Eczema | 22.20 | 14.07 | 44 | 233111 | 13325 | 29705998 |
Cholangitis | 22.09 | 14.07 | 17 | 233138 | 7785 | 29711538 |
Heart rate increased | 21.96 | 14.07 | 194 | 232961 | 38527 | 29680796 |
Visceral leishmaniasis | 21.91 | 14.07 | 23 | 233132 | 473 | 29718850 |
Amylase increased | 21.89 | 14.07 | 9 | 233146 | 5832 | 29713491 |
Rash macular | 21.87 | 14.07 | 147 | 233008 | 10220 | 29709103 |
Blood pressure abnormal | 21.78 | 14.07 | 110 | 233045 | 6889 | 29712434 |
Cellulitis | 21.76 | 14.07 | 497 | 232658 | 46287 | 29673036 |
Brain injury | 21.70 | 14.07 | 8 | 233147 | 5540 | 29713783 |
Pulmonary congestion | 21.67 | 14.07 | 39 | 233116 | 12248 | 29707075 |
Fluid overload | 21.66 | 14.07 | 76 | 233079 | 19016 | 29700307 |
Idiopathic pulmonary fibrosis | 21.61 | 14.07 | 3 | 233152 | 4066 | 29715257 |
Ischaemic cardiomyopathy | 21.58 | 14.07 | 11 | 233144 | 6286 | 29713037 |
Hypoxic-ischaemic encephalopathy | 21.55 | 14.07 | 5 | 233150 | 4682 | 29714641 |
Lymphocyte count decreased | 21.52 | 14.07 | 76 | 233079 | 18979 | 29700344 |
Hyperglycaemia | 21.47 | 14.07 | 173 | 232982 | 35027 | 29684296 |
Myeloma cast nephropathy | 21.43 | 14.07 | 10 | 233145 | 48 | 29719275 |
Spinal cord compression | 21.35 | 14.07 | 70 | 233085 | 3596 | 29715727 |
Hepatocellular carcinoma | 21.33 | 14.07 | 26 | 233129 | 9584 | 29709739 |
Multiple fractures | 21.27 | 14.07 | 38 | 233117 | 1316 | 29718007 |
Pulse absent | 21.23 | 14.07 | 8 | 233147 | 5465 | 29713858 |
Anosmia | 21.14 | 14.07 | 49 | 233106 | 2051 | 29717272 |
Tuberculosis | 21.14 | 14.07 | 19 | 233136 | 8058 | 29711265 |
Atrioventricular block first degree | 20.94 | 14.07 | 9 | 233146 | 5679 | 29713644 |
Neutrophil count abnormal | 20.85 | 14.07 | 38 | 233117 | 1337 | 29717986 |
Klebsiella infection | 20.82 | 14.07 | 14 | 233141 | 6873 | 29712450 |
Cervical vertebral fracture | 20.80 | 14.07 | 44 | 233111 | 1730 | 29717593 |
Pneumonitis | 20.63 | 14.07 | 127 | 233028 | 27327 | 29691996 |
Blood magnesium decreased | 20.58 | 14.07 | 91 | 233064 | 5392 | 29713931 |
Orthopnoea | 20.56 | 14.07 | 5 | 233150 | 4535 | 29714788 |
Acute graft versus host disease | 20.47 | 14.07 | 10 | 233145 | 5854 | 29713469 |
Abdominal pain lower | 20.39 | 14.07 | 23 | 233132 | 8775 | 29710548 |
Hypernatraemia | 20.32 | 14.07 | 17 | 233138 | 7467 | 29711856 |
Hypertransaminasaemia | 20.31 | 14.07 | 3 | 233152 | 3882 | 29715441 |
Cystitis haemorrhagic | 20.31 | 14.07 | 6 | 233149 | 4781 | 29714542 |
Aspergillus infection | 20.27 | 14.07 | 30 | 233125 | 10184 | 29709139 |
Portal hypertension | 20.23 | 14.07 | 3 | 233152 | 3870 | 29715453 |
Hepatic necrosis | 20.16 | 14.07 | 3 | 233152 | 3860 | 29715463 |
Aspiration | 19.97 | 14.07 | 32 | 233123 | 10519 | 29708804 |
Paraproteinaemia | 19.95 | 14.07 | 18 | 233137 | 305 | 29719018 |
Skin necrosis | 19.92 | 14.07 | 6 | 233149 | 4721 | 29714602 |
Electrocardiogram ST segment elevation | 19.91 | 14.07 | 5 | 233150 | 4437 | 29714886 |
Hypercapnia | 19.88 | 14.07 | 3 | 233152 | 3821 | 29715502 |
Anger | 19.87 | 14.07 | 35 | 233120 | 11085 | 29708238 |
Atelectasis | 19.85 | 14.07 | 62 | 233093 | 16076 | 29703247 |
Blood chloride decreased | 19.81 | 14.07 | 3 | 233152 | 3810 | 29715513 |
Productive cough | 19.78 | 14.07 | 144 | 233011 | 29809 | 29689514 |
Chronic graft versus host disease | 19.74 | 14.07 | 4 | 233151 | 4115 | 29715208 |
Mental status changes | 19.63 | 14.07 | 189 | 232966 | 36890 | 29682433 |
Blood cholesterol increased | 19.62 | 14.07 | 67 | 233088 | 16903 | 29702420 |
Therapeutic product effect decreased | 19.58 | 14.07 | 139 | 233016 | 28937 | 29690386 |
Salivary hypersecretion | 19.56 | 14.07 | 18 | 233137 | 7548 | 29711775 |
Partial seizures | 19.49 | 14.07 | 3 | 233152 | 3764 | 29715559 |
Superficial spreading melanoma stage I | 19.46 | 14.07 | 7 | 233148 | 14 | 29719309 |
Ketoacidosis | 19.34 | 14.07 | 3 | 233152 | 3743 | 29715580 |
Pleural effusion | 19.33 | 14.07 | 434 | 232721 | 73632 | 29645691 |
Brain herniation | 19.30 | 14.07 | 3 | 233152 | 3737 | 29715586 |
Irritability | 19.27 | 14.07 | 103 | 233052 | 22947 | 29696376 |
Cardiac murmur | 19.21 | 14.07 | 15 | 233140 | 6819 | 29712504 |
Duodenitis | 19.20 | 14.07 | 4 | 233151 | 4036 | 29715287 |
Bladder transitional cell carcinoma | 19.19 | 14.07 | 52 | 233103 | 2401 | 29716922 |
Toxic encephalopathy | 19.15 | 14.07 | 6 | 233149 | 4603 | 29714720 |
Device occlusion | 19.10 | 14.07 | 12 | 233143 | 6108 | 29713215 |
Appendix disorder | 19.09 | 14.07 | 23 | 233132 | 553 | 29718770 |
Euphoric mood | 18.90 | 14.07 | 5 | 233150 | 4285 | 29715038 |
Skin plaque | 18.75 | 14.07 | 3 | 233152 | 3659 | 29715664 |
Lymphocytic leukaemia | 18.74 | 14.07 | 13 | 233142 | 147 | 29719176 |
Haematocrit decreased | 18.67 | 14.07 | 151 | 233004 | 30548 | 29688775 |
Blood immunoglobulin A increased | 18.65 | 14.07 | 17 | 233138 | 292 | 29719031 |
Lethargy | 18.64 | 14.07 | 207 | 232948 | 39312 | 29680011 |
Bone loss | 18.46 | 14.07 | 23 | 233132 | 573 | 29718750 |
Muscle strain | 18.38 | 14.07 | 67 | 233088 | 3632 | 29715691 |
Haemolytic anaemia | 18.35 | 14.07 | 31 | 233124 | 9979 | 29709344 |
Myopathy | 18.31 | 14.07 | 34 | 233121 | 10552 | 29708771 |
Monocyte count increased | 18.31 | 14.07 | 3 | 233152 | 3595 | 29715728 |
Scar | 18.10 | 14.07 | 11 | 233144 | 5700 | 29713623 |
Musculoskeletal pain | 17.99 | 14.07 | 154 | 233001 | 30786 | 29688537 |
Hyperthyroidism | 17.88 | 14.07 | 22 | 233133 | 8076 | 29711247 |
Splenomegaly | 17.87 | 14.07 | 50 | 233105 | 13430 | 29705893 |
Colon cancer | 17.83 | 14.07 | 119 | 233036 | 8253 | 29711070 |
Light chain analysis decreased | 17.75 | 14.07 | 6 | 233149 | 9 | 29719314 |
Immunoglobulins abnormal | 17.75 | 14.07 | 6 | 233149 | 9 | 29719314 |
Tenosynovitis | 17.73 | 14.07 | 3 | 233152 | 3512 | 29715811 |
Bladder transitional cell carcinoma stage 0 | 17.72 | 14.07 | 12 | 233143 | 130 | 29719193 |
Lung adenocarcinoma | 17.70 | 14.07 | 71 | 233084 | 4028 | 29715295 |
Sternal fracture | 17.69 | 14.07 | 22 | 233133 | 547 | 29718776 |
Gastrooesophageal reflux disease | 17.68 | 14.07 | 163 | 232992 | 32092 | 29687231 |
Exercise tolerance decreased | 17.66 | 14.07 | 4 | 233151 | 3808 | 29715515 |
Cardiac tamponade | 17.66 | 14.07 | 7 | 233148 | 4637 | 29714686 |
BK virus infection | 17.57 | 14.07 | 6 | 233149 | 4358 | 29714965 |
Intracranial pressure increased | 17.56 | 14.07 | 3 | 233152 | 3487 | 29715836 |
Intraocular pressure increased | 17.47 | 14.07 | 9 | 233146 | 5111 | 29714212 |
Erectile dysfunction | 17.39 | 14.07 | 77 | 233078 | 18025 | 29701298 |
Portal vein thrombosis | 17.38 | 14.07 | 3 | 233152 | 3461 | 29715862 |
Respiratory tract infection | 17.37 | 14.07 | 191 | 232964 | 15315 | 29704008 |
Contusion | 17.36 | 14.07 | 341 | 232814 | 30939 | 29688384 |
Sudden death | 17.35 | 14.07 | 62 | 233093 | 15430 | 29703893 |
Gastric ulcer | 17.28 | 14.07 | 60 | 233095 | 15061 | 29704262 |
Skin atrophy | 17.19 | 14.07 | 39 | 233116 | 1609 | 29717714 |
Papillary thyroid cancer | 17.17 | 14.07 | 23 | 233132 | 617 | 29718706 |
Gait inability | 17.12 | 14.07 | 223 | 232932 | 18618 | 29700705 |
Haematochezia | 17.05 | 14.07 | 177 | 232978 | 34045 | 29685278 |
Hemiplegia | 17.04 | 14.07 | 16 | 233139 | 6645 | 29712678 |
Abdominal discomfort | 17.04 | 14.07 | 499 | 232656 | 48292 | 29671031 |
Humerus fracture | 17.02 | 14.07 | 49 | 233106 | 2344 | 29716979 |
Hyperammonaemia | 16.98 | 14.07 | 11 | 233144 | 5509 | 29713814 |
Upper-airway cough syndrome | 16.92 | 14.07 | 53 | 233102 | 2657 | 29716666 |
Type 1 diabetes mellitus | 16.90 | 14.07 | 4 | 233151 | 3695 | 29715628 |
Congestive cardiomyopathy | 16.86 | 14.07 | 16 | 233139 | 6611 | 29712712 |
Vertigo | 16.85 | 14.07 | 105 | 233050 | 22530 | 29696793 |
Pain | 16.73 | 14.07 | 1138 | 232017 | 171503 | 29547820 |
Plasma cell myeloma refractory | 16.73 | 14.07 | 8 | 233147 | 41 | 29719282 |
Bradyphrenia | 16.71 | 14.07 | 5 | 233150 | 3952 | 29715371 |
Swollen tongue | 16.71 | 14.07 | 50 | 233105 | 13142 | 29706181 |
Stevens-Johnson syndrome | 16.67 | 14.07 | 75 | 233080 | 17481 | 29701842 |
Colon cancer metastatic | 16.62 | 14.07 | 39 | 233116 | 1646 | 29717677 |
Device related infection | 16.57 | 14.07 | 72 | 233083 | 16943 | 29702380 |
Respiratory acidosis | 16.54 | 14.07 | 6 | 233149 | 4196 | 29715127 |
Electrocardiogram abnormal | 16.48 | 14.07 | 13 | 233142 | 5879 | 29713444 |
Loss of consciousness | 16.46 | 14.07 | 481 | 232674 | 78894 | 29640429 |
Adenocarcinoma gastric | 16.44 | 14.07 | 31 | 233124 | 1120 | 29718203 |
Pyelonephritis | 16.44 | 14.07 | 11 | 233144 | 5415 | 29713908 |
Autoimmune hepatitis | 16.42 | 14.07 | 4 | 233151 | 3623 | 29715700 |
Disease complication | 16.39 | 14.07 | 51 | 233104 | 2548 | 29716775 |
Acute generalised exanthematous pustulosis | 16.38 | 14.07 | 14 | 233141 | 6084 | 29713239 |
Urinary incontinence | 16.30 | 14.07 | 72 | 233083 | 16868 | 29702455 |
Duodenal ulcer haemorrhage | 16.26 | 14.07 | 8 | 233147 | 4664 | 29714659 |
Prostate cancer stage I | 16.19 | 14.07 | 7 | 233148 | 27 | 29719296 |
Lyme disease | 16.16 | 14.07 | 24 | 233131 | 710 | 29718613 |
Diverticulum intestinal | 16.12 | 14.07 | 3 | 233152 | 3279 | 29716044 |
Acute coronary syndrome | 16.10 | 14.07 | 53 | 233102 | 13520 | 29705803 |
Gastrointestinal infection | 16.09 | 14.07 | 65 | 233090 | 3700 | 29715623 |
Bladder disorder | 16.08 | 14.07 | 54 | 233101 | 2809 | 29716514 |
Diverticulitis | 16.07 | 14.07 | 207 | 232948 | 17238 | 29702085 |
Squamous cell carcinoma of the hypopharynx | 16.07 | 14.07 | 6 | 233149 | 14 | 29719309 |
Chronic kidney disease | 16.00 | 14.07 | 203 | 232952 | 37635 | 29681688 |
Gingival discolouration | 15.89 | 14.07 | 5 | 233150 | 5 | 29719318 |
Aplastic anaemia | 15.87 | 14.07 | 12 | 233143 | 5544 | 29713779 |
Gastric haemorrhage | 15.85 | 14.07 | 31 | 233124 | 9436 | 29709887 |
Kidney infection | 15.71 | 14.07 | 74 | 233081 | 4504 | 29714819 |
Lymphadenopathy | 15.71 | 14.07 | 118 | 233037 | 24258 | 29695065 |
Vital functions abnormal | 15.69 | 14.07 | 10 | 233145 | 97 | 29719226 |
Blood glucose increased | 15.64 | 14.07 | 362 | 232793 | 61168 | 29658155 |
Ventricular extrasystoles | 15.63 | 14.07 | 42 | 233113 | 11432 | 29707891 |
Mental disorder | 15.62 | 14.07 | 53 | 233102 | 13396 | 29705927 |
Syncope | 15.55 | 14.07 | 523 | 232632 | 84380 | 29634943 |
Pneumothorax | 15.48 | 14.07 | 69 | 233086 | 16124 | 29703199 |
Plasma cell myeloma in remission | 15.45 | 14.07 | 4 | 233151 | 0 | 29719323 |
Hepatic amyloidosis | 15.45 | 14.07 | 4 | 233151 | 0 | 29719323 |
Plasma cells decreased | 15.45 | 14.07 | 4 | 233151 | 0 | 29719323 |
Occult blood positive | 15.43 | 14.07 | 5 | 233150 | 3755 | 29715568 |
Eye infection | 15.43 | 14.07 | 53 | 233102 | 2789 | 29716534 |
Hypothyroidism | 15.39 | 14.07 | 62 | 233093 | 14901 | 29704422 |
Feeling jittery | 15.31 | 14.07 | 65 | 233090 | 3783 | 29715540 |
Leukoencephalopathy | 15.27 | 14.07 | 6 | 233149 | 3996 | 29715327 |
Musculoskeletal chest pain | 15.25 | 14.07 | 122 | 233033 | 8963 | 29710360 |
Bundle branch block left | 15.17 | 14.07 | 11 | 233144 | 5193 | 29714130 |
Normochromic normocytic anaemia | 15.07 | 14.07 | 6 | 233149 | 3964 | 29715359 |
Aplasia pure red cell | 15.01 | 14.07 | 13 | 233142 | 5613 | 29713710 |
Blood calcium abnormal | 15.00 | 14.07 | 18 | 233137 | 431 | 29718892 |
Immunoglobulins increased | 15.00 | 14.07 | 12 | 233143 | 171 | 29719152 |
Anal squamous cell carcinoma | 14.96 | 14.07 | 9 | 233146 | 78 | 29719245 |
Salmonellosis | 14.96 | 14.07 | 23 | 233132 | 702 | 29718621 |
Hepatitis fulminant | 14.89 | 14.07 | 6 | 233149 | 3935 | 29715388 |
Intestinal obstruction | 14.87 | 14.07 | 221 | 232934 | 18991 | 29700332 |
Renal amyloidosis | 14.83 | 14.07 | 8 | 233147 | 55 | 29719268 |
Central nervous system lesion | 14.79 | 14.07 | 10 | 233145 | 4896 | 29714427 |
Psychiatric symptom | 14.77 | 14.07 | 4 | 233151 | 3375 | 29715948 |
Cardiotoxicity | 14.70 | 14.07 | 8 | 233147 | 4406 | 29714917 |
Dermatitis exfoliative | 14.70 | 14.07 | 22 | 233133 | 7434 | 29711889 |
Bone marrow failure | 14.66 | 14.07 | 319 | 232836 | 29466 | 29689857 |
Cerebral ischaemia | 14.60 | 14.07 | 16 | 233139 | 6184 | 29713139 |
Bilirubin conjugated increased | 14.59 | 14.07 | 4 | 233151 | 3347 | 29715976 |
Emotional disorder | 14.55 | 14.07 | 11 | 233144 | 5083 | 29714240 |
Transitional cell cancer of the renal pelvis and ureter | 14.54 | 14.07 | 6 | 233149 | 20 | 29719303 |
Discomfort | 14.44 | 14.07 | 60 | 233095 | 14296 | 29705027 |
Laryngeal oedema | 14.34 | 14.07 | 4 | 233151 | 3310 | 29716013 |
Haemorrhagic stroke | 14.32 | 14.07 | 16 | 233139 | 6131 | 29713192 |
Gastric infection | 14.23 | 14.07 | 27 | 233128 | 980 | 29718343 |
Respiration abnormal | 14.11 | 14.07 | 49 | 233106 | 2593 | 29716730 |
Ecchymosis | 14.11 | 14.07 | 18 | 233137 | 6504 | 29712819 |
Source | Code | Description |
---|---|---|
ATC | L04AX04 | ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS IMMUNOSUPPRESSANTS IMMUNOSUPPRESSANTS Other immunosuppressants |
MeSH PA | D020533 | Angiogenesis Inhibitors |
MeSH PA | D000970 | Antineoplastic Agents |
MeSH PA | D006131 | Growth Inhibitors |
MeSH PA | D006133 | Growth Substances |
MeSH PA | D007155 | Immunologic Factors |
FDA EPC | N0000184014 | Thalidomide Analog |
CHEBI has role | CHEBI:35610 | cytostatic |
CHEBI has role | CHEBI:48422 | angiostatic agents |
CHEBI has role | CHEBI:50846 | biomodulator |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Follicular lymphoma | indication | 55150002 | |
Multiple myeloma | indication | 109989006 | DOID:9538 |
Myelodysplastic syndrome | indication | 109995007 | |
Mantle cell lymphoma | indication | 443487006 | |
Marginal zone lymphoma | indication | 447100004 | |
Deep venous thrombosis | contraindication | 128053003 | |
Impaired renal function disorder | contraindication | 197663003 | |
Pulmonary thromboembolism | contraindication | 233935004 | |
Pregnancy, function | contraindication | 289908002 | |
Thrombocytopenic disorder | contraindication | 302215000 | DOID:1588 |
Neutropenic disorder | contraindication | 303011007 | DOID:1227 |
Thromboembolic disorder | contraindication | 371039008 | |
Primary malignant neoplasm | contraindication | 372087000 | |
Breastfeeding (mother) | contraindication | 413712001 | |
Chemotherapy-Induced Hyperuricemia | contraindication |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 8.17 | acidic |
pKa2 | 3.13 | Basic |
None
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Exclusivity date | Description |
---|---|---|---|---|---|---|---|---|---|
10MG | REVLIMID | CELGENE | N021880 | Dec. 27, 2005 | RX | CAPSULE | ORAL | Feb. 17, 2022 | FOR USE IN COMBINULLTION WITH DEXAMETHASONE FOR THE TREATMENT OF PATIENTS WITH MULTIPLE MYELOMA WHO HAVE NOT RECEIVED AT LEAST ONE PRIOR THERAPY (FIRST LINE TREATMENT) |
15MG | REVLIMID | CELGENE | N021880 | June 29, 2006 | RX | CAPSULE | ORAL | Feb. 17, 2022 | FOR USE IN COMBINULLTION WITH DEXAMETHASONE FOR THE TREATMENT OF PATIENTS WITH MULTIPLE MYELOMA WHO HAVE NOT RECEIVED AT LEAST ONE PRIOR THERAPY (FIRST LINE TREATMENT) |
2.5MG | REVLIMID | CELGENE | N021880 | Dec. 21, 2011 | RX | CAPSULE | ORAL | Feb. 17, 2022 | FOR USE IN COMBINULLTION WITH DEXAMETHASONE FOR THE TREATMENT OF PATIENTS WITH MULTIPLE MYELOMA WHO HAVE NOT RECEIVED AT LEAST ONE PRIOR THERAPY (FIRST LINE TREATMENT) |
20MG | REVLIMID | CELGENE | N021880 | June 5, 2013 | RX | CAPSULE | ORAL | Feb. 17, 2022 | FOR USE IN COMBINULLTION WITH DEXAMETHASONE FOR THE TREATMENT OF PATIENTS WITH MULTIPLE MYELOMA WHO HAVE NOT RECEIVED AT LEAST ONE PRIOR THERAPY (FIRST LINE TREATMENT) |
25MG | REVLIMID | CELGENE | N021880 | June 29, 2006 | RX | CAPSULE | ORAL | Feb. 17, 2022 | FOR USE IN COMBINULLTION WITH DEXAMETHASONE FOR THE TREATMENT OF PATIENTS WITH MULTIPLE MYELOMA WHO HAVE NOT RECEIVED AT LEAST ONE PRIOR THERAPY (FIRST LINE TREATMENT) |
5MG | REVLIMID | CELGENE | N021880 | Dec. 27, 2005 | RX | CAPSULE | ORAL | Feb. 17, 2022 | FOR USE IN COMBINULLTION WITH DEXAMETHASONE FOR THE TREATMENT OF PATIENTS WITH MULTIPLE MYELOMA WHO HAVE NOT RECEIVED AT LEAST ONE PRIOR THERAPY (FIRST LINE TREATMENT) |
10MG | REVLIMID | CELGENE | N021880 | Dec. 27, 2005 | RX | CAPSULE | ORAL | May 28, 2022 | USED IN COMBINULLTION WITH A RITUXIMAB PRODUCT, ARE INDICATED FOR THE TREATMENT OF ADULT PATIENTS WITH PREVIOUSLY TREATED FOLLICULAR LYMPHOMA (FL) |
10MG | REVLIMID | CELGENE | N021880 | Dec. 27, 2005 | RX | CAPSULE | ORAL | May 28, 2022 | USED IN COMBINULLTION WITH A RITUXIMAB PRODUCT, ARE INDICATED FOR THE TREATMENT OF ADULT PATIENTS WITH PREVIOUSLY TREATED MARGINULLL ZONE LYMPHOMA (MZL) |
15MG | REVLIMID | CELGENE | N021880 | June 29, 2006 | RX | CAPSULE | ORAL | May 28, 2022 | USED IN COMBINULLTION WITH A RITUXIMAB PRODUCT, ARE INDICATED FOR THE TREATMENT OF ADULT PATIENTS WITH PREVIOUSLY TREATED FOLLICULAR LYMPHOMA (FL) |
15MG | REVLIMID | CELGENE | N021880 | June 29, 2006 | RX | CAPSULE | ORAL | May 28, 2022 | USED IN COMBINULLTION WITH A RITUXIMAB PRODUCT, ARE INDICATED FOR THE TREATMENT OF ADULT PATIENTS WITH PREVIOUSLY TREATED MARGINULLL ZONE LYMPHOMA (MZL) |
2.5MG | REVLIMID | CELGENE | N021880 | Dec. 21, 2011 | RX | CAPSULE | ORAL | May 28, 2022 | USED IN COMBINULLTION WITH A RITUXIMAB PRODUCT, ARE INDICATED FOR THE TREATMENT OF ADULT PATIENTS WITH PREVIOUSLY TREATED FOLLICULAR LYMPHOMA (FL) |
2.5MG | REVLIMID | CELGENE | N021880 | Dec. 21, 2011 | RX | CAPSULE | ORAL | May 28, 2022 | USED IN COMBINULLTION WITH A RITUXIMAB PRODUCT, ARE INDICATED FOR THE TREATMENT OF ADULT PATIENTS WITH PREVIOUSLY TREATED MARGINULLL ZONE LYMPHOMA (MZL) |
20MG | REVLIMID | CELGENE | N021880 | June 5, 2013 | RX | CAPSULE | ORAL | May 28, 2022 | USED IN COMBINULLTION WITH A RITUXIMAB PRODUCT, ARE INDICATED FOR THE TREATMENT OF ADULT PATIENTS WITH PREVIOUSLY TREATED FOLLICULAR LYMPHOMA (FL) |
20MG | REVLIMID | CELGENE | N021880 | June 5, 2013 | RX | CAPSULE | ORAL | May 28, 2022 | USED IN COMBINULLTION WITH A RITUXIMAB PRODUCT, ARE INDICATED FOR THE TREATMENT OF ADULT PATIENTS WITH PREVIOUSLY TREATED MARGINULLL ZONE LYMPHOMA (MZL) |
25MG | REVLIMID | CELGENE | N021880 | June 29, 2006 | RX | CAPSULE | ORAL | May 28, 2022 | USED IN COMBINULLTION WITH A RITUXIMAB PRODUCT, ARE INDICATED FOR THE TREATMENT OF ADULT PATIENTS WITH PREVIOUSLY TREATED FOLLICULAR LYMPHOMA (FL) |
25MG | REVLIMID | CELGENE | N021880 | June 29, 2006 | RX | CAPSULE | ORAL | May 28, 2022 | USED IN COMBINULLTION WITH A RITUXIMAB PRODUCT, ARE INDICATED FOR THE TREATMENT OF ADULT PATIENTS WITH PREVIOUSLY TREATED MARGINULLL ZONE LYMPHOMA (MZL) |
5MG | REVLIMID | CELGENE | N021880 | Dec. 27, 2005 | RX | CAPSULE | ORAL | May 28, 2022 | USED IN COMBINULLTION WITH A RITUXIMAB PRODUCT, ARE INDICATED FOR THE TREATMENT OF ADULT PATIENTS WITH PREVIOUSLY TREATED FOLLICULAR LYMPHOMA (FL) |
5MG | REVLIMID | CELGENE | N021880 | Dec. 27, 2005 | RX | CAPSULE | ORAL | May 28, 2022 | USED IN COMBINULLTION WITH A RITUXIMAB PRODUCT, ARE INDICATED FOR THE TREATMENT OF ADULT PATIENTS WITH PREVIOUSLY TREATED MARGINULLL ZONE LYMPHOMA (MZL) |
10MG | REVLIMID | CELGENE | N021880 | Dec. 27, 2005 | RX | CAPSULE | ORAL | Feb. 22, 2024 | TREATMENT OF MULTIPLE MYELOMA (MM), AS MAINTENULLNCE FOLLOWING AUTOLOGOUS HEMATOPOIETIC STEM CELL TRANSPLANTATION (AUTO-HSCT) |
15MG | REVLIMID | CELGENE | N021880 | June 29, 2006 | RX | CAPSULE | ORAL | Feb. 22, 2024 | TREATMENT OF MULTIPLE MYELOMA (MM), AS MAINTENULLNCE FOLLOWING AUTOLOGOUS HEMATOPOIETIC STEM CELL TRANSPLANTATION (AUTO-HSCT) |
2.5MG | REVLIMID | CELGENE | N021880 | Dec. 21, 2011 | RX | CAPSULE | ORAL | Feb. 22, 2024 | TREATMENT OF MULTIPLE MYELOMA (MM), AS MAINTENULLNCE FOLLOWING AUTOLOGOUS HEMATOPOIETIC STEM CELL TRANSPLANTATION (AUTO-HSCT) |
20MG | REVLIMID | CELGENE | N021880 | June 5, 2013 | RX | CAPSULE | ORAL | Feb. 22, 2024 | TREATMENT OF MULTIPLE MYELOMA (MM), AS MAINTENULLNCE FOLLOWING AUTOLOGOUS HEMATOPOIETIC STEM CELL TRANSPLANTATION (AUTO-HSCT) |
25MG | REVLIMID | CELGENE | N021880 | June 29, 2006 | RX | CAPSULE | ORAL | Feb. 22, 2024 | TREATMENT OF MULTIPLE MYELOMA (MM), AS MAINTENULLNCE FOLLOWING AUTOLOGOUS HEMATOPOIETIC STEM CELL TRANSPLANTATION (AUTO-HSCT) |
5MG | REVLIMID | CELGENE | N021880 | Dec. 27, 2005 | RX | CAPSULE | ORAL | Feb. 22, 2024 | TREATMENT OF MULTIPLE MYELOMA (MM), AS MAINTENULLNCE FOLLOWING AUTOLOGOUS HEMATOPOIETIC STEM CELL TRANSPLANTATION (AUTO-HSCT) |
10MG | REVLIMID | CELGENE | N021880 | Dec. 27, 2005 | RX | CAPSULE | ORAL | May 28, 2026 | INDICATED IN COMBINULLTION WITH A RITUXIMAB PRODUCT FOR THE TREATMENT OF ADULT PATIENTS WITH PREVIOUSLY TREATED FOLLICULAR LYMPHOMA (FL) |
10MG | REVLIMID | CELGENE | N021880 | Dec. 27, 2005 | RX | CAPSULE | ORAL | May 28, 2026 | INDICATED IN COMBINULLTION WITH A RITUXIMAB PRODUCT FOR THE TREATMENT OF ADULT PATIENTS WITH PREVIOUSLY TREATED MARGINULLL ZONE LYMPHOMA (MZL) |
15MG | REVLIMID | CELGENE | N021880 | June 29, 2006 | RX | CAPSULE | ORAL | May 28, 2026 | INDICATED IN COMBINULLTION WITH A RITUXIMAB PRODUCT FOR THE TREATMENT OF ADULT PATIENTS WITH PREVIOUSLY TREATED FOLLICULAR LYMPHOMA (FL) |
15MG | REVLIMID | CELGENE | N021880 | June 29, 2006 | RX | CAPSULE | ORAL | May 28, 2026 | INDICATED IN COMBINULLTION WITH A RITUXIMAB PRODUCT FOR THE TREATMENT OF ADULT PATIENTS WITH PREVIOUSLY TREATED MARGINULLL ZONE LYMPHOMA (MZL) |
2.5MG | REVLIMID | CELGENE | N021880 | Dec. 21, 2011 | RX | CAPSULE | ORAL | May 28, 2026 | INDICATED IN COMBINULLTION WITH A RITUXIMAB PRODUCT FOR THE TREATMENT OF ADULT PATIENTS WITH PREVIOUSLY TREATED FOLLICULAR LYMPHOMA (FL) |
2.5MG | REVLIMID | CELGENE | N021880 | Dec. 21, 2011 | RX | CAPSULE | ORAL | May 28, 2026 | INDICATED IN COMBINULLTION WITH A RITUXIMAB PRODUCT FOR THE TREATMENT OF ADULT PATIENTS WITH PREVIOUSLY TREATED MARGINULLL ZONE LYMPHOMA (MZL) |
20MG | REVLIMID | CELGENE | N021880 | June 5, 2013 | RX | CAPSULE | ORAL | May 28, 2026 | INDICATED IN COMBINULLTION WITH A RITUXIMAB PRODUCT FOR THE TREATMENT OF ADULT PATIENTS WITH PREVIOUSLY TREATED FOLLICULAR LYMPHOMA (FL) |
20MG | REVLIMID | CELGENE | N021880 | June 5, 2013 | RX | CAPSULE | ORAL | May 28, 2026 | INDICATED IN COMBINULLTION WITH A RITUXIMAB PRODUCT FOR THE TREATMENT OF ADULT PATIENTS WITH PREVIOUSLY TREATED MARGINULLL ZONE LYMPHOMA (MZL) |
25MG | REVLIMID | CELGENE | N021880 | June 29, 2006 | RX | CAPSULE | ORAL | May 28, 2026 | INDICATED IN COMBINULLTION WITH A RITUXIMAB PRODUCT FOR THE TREATMENT OF ADULT PATIENTS WITH PREVIOUSLY TREATED FOLLICULAR LYMPHOMA (FL) |
25MG | REVLIMID | CELGENE | N021880 | June 29, 2006 | RX | CAPSULE | ORAL | May 28, 2026 | INDICATED IN COMBINULLTION WITH A RITUXIMAB PRODUCT FOR THE TREATMENT OF ADULT PATIENTS WITH PREVIOUSLY TREATED MARGINULLL ZONE LYMPHOMA (MZL) |
5MG | REVLIMID | CELGENE | N021880 | Dec. 27, 2005 | RX | CAPSULE | ORAL | May 28, 2026 | INDICATED IN COMBINULLTION WITH A RITUXIMAB PRODUCT FOR THE TREATMENT OF ADULT PATIENTS WITH PREVIOUSLY TREATED FOLLICULAR LYMPHOMA (FL) |
5MG | REVLIMID | CELGENE | N021880 | Dec. 27, 2005 | RX | CAPSULE | ORAL | May 28, 2026 | INDICATED IN COMBINULLTION WITH A RITUXIMAB PRODUCT FOR THE TREATMENT OF ADULT PATIENTS WITH PREVIOUSLY TREATED MARGINULLL ZONE LYMPHOMA (MZL) |
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Protein cereblon | Cytosolic other | MODULATOR | EC50 | 6.53 | SCIENTIFIC LITERATURE | SCIENTIFIC LITERATURE | |||
Tumor necrosis factor | Cytokine | IC50 | 7.89 | WOMBAT-PK |
ID | Source |
---|---|
4025089 | VUID |
N0000175347 | NUI |
D04687 | KEGG_DRUG |
4025089 | VANDF |
C1144149 | UMLSCUI |
CHEBI:63791 | CHEBI |
CHEMBL848 | ChEMBL_ID |
D000077269 | MESH_DESCRIPTOR_UI |
DB00480 | DRUGBANK_ID |
7331 | IUPHAR_LIGAND_ID |
8505 | INN_ID |
F0P408N6V4 | UNII |
216326 | PUBCHEM_CID |
337535 | RXNORM |
20816 | MMSL |
73707 | MMSL |
d05696 | MMSL |
011171 | NDDF |
421471009 | SNOMEDCT_US |
421737001 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Revlimid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 59572-402 | CAPSULE | 2.50 mg | ORAL | NDA | 32 sections |
Revlimid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 59572-405 | CAPSULE | 5 mg | ORAL | NDA | 32 sections |
Revlimid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 59572-410 | CAPSULE | 10 mg | ORAL | NDA | 32 sections |
Revlimid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 59572-415 | CAPSULE | 15 mg | ORAL | NDA | 32 sections |
Revlimid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 59572-420 | CAPSULE | 20 mg | ORAL | NDA | 32 sections |
Revlimid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 59572-425 | CAPSULE | 25 mg | ORAL | NDA | 32 sections |