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azatadine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| histamine-H1 receptor antagonists, tricyclic compounds | 268 | 3964-81-6 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
indulian (UD 21;71k) is dimaleate; do not confuse with AZACITIDINE
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 2 | mg | O |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| S (Water solubility) | 0.11 mg/mL | Bocci G, Oprea TI, Benet LZ |
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Bocci G, Oprea TI, Benet LZ |
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2B,AXL,BRAF,CAMK2D,CDK5,EIF2AK3,ERBB2,GRK2,ITK,MAPK10,NTRK2,PDK4,PRKDC,TGFBR1 | 14 | |||
| kinase-selectivity-class | AXL | 1 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| March 29, 1977 | FDA |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | R06AX09 | RESPIRATORY SYSTEM ANTIHISTAMINES FOR SYSTEMIC USE ANTIHISTAMINES FOR SYSTEMIC USE Other antihistamines for systemic use |
| MeSH PA | D006633 | Histamine Antagonists |
| MeSH PA | D006634 | Histamine H1 Antagonists |
| MeSH PA | D018377 | Neurotransmitter Agents |
| MeSH PA | D018494 | Histamine Agents |
| MeSH PA | D018678 | Cholinergic Agents |
| MeSH PA | D018680 | Cholinergic Antagonists |
| CHEBI has role | CHEBI:37955 | H<small><sub>1</sub></small>-receptor antagonist |
| CHEBI has role | CHEBI:50857 | anti-allergic agent |
Related Drugs by ATC class:
R06AX Other antihistamines for systemic use 26 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Dermatographic urticaria | indication | 7632005 | DOID:743 |
| Vasomotor rhinitis | indication | 8229003 | DOID:4730 |
| Allergic rhinitis | indication | 61582004 | |
| Nasal discharge | indication | 64531003 | |
| Nasal congestion | indication | 68235000 | |
| Sneezing | indication | 76067001 | |
| Common cold | indication | 82272006 | DOID:10459 |
| Urticaria | indication | 126485001 | |
| Seasonal allergic rhinitis | indication | 367498001 | |
| Itching of skin | indication | 418363000 | |
| Allergic conjunctivitis | indication | 473460002 | DOID:11204 |
| Anaphylaxis Adjunct | indication | ||
| Hyperthyroidism | contraindication | 34486009 | DOID:7998 |
| Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
| Coronary arteriosclerosis | contraindication | 53741008 | DOID:3393 |
| Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
| Benign prostatic hyperplasia | contraindication | 266569009 | |
| Retention of urine | contraindication | 267064002 | |
| Angle-closure glaucoma | contraindication | 392291006 | DOID:13550 |
| Hypertensive urgency | contraindication | 443482000 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 9.08 | Basic |
| pKa2 | 3.59 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Histamine H1 receptor | GPCR | ANTAGONIST | DRUGBANK | CHEMBL | |||||
| Histamine H1 receptor | GPCR | Ki | 8.41 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4019620 | VUID |
| N0000147714 | NUI |
| D00662 | KEGG_DRUG |
| 18600 | RXNORM |
| C0052759 | UMLSCUI |
| CHEBI:2946 | CHEBI |
| CHEMBL946 | ChEMBL_ID |
| DB00719 | DRUGBANK_ID |
| CHEMBL3544908 | ChEMBL_ID |
| C006656 | MESH_SUPPLEMENTAL_RECORD_UI |
| 19861 | PUBCHEM_CID |
| 7119 | IUPHAR_LIGAND_ID |
| 2327 | INN_ID |
| 3978-86-7 | SECONDARY_CAS_RN |
| 94Z39NID6C | UNII |
| 4233 | MMSL |
| d00791 | MMSL |
| 4018803 | VANDF |
| 4019620 | VANDF |
| 003409 | NDDF |
| 004805 | NDDF |
| 1594006 | SNOMEDCT_US |
| 372662006 | SNOMEDCT_US |
| 45159007 | SNOMEDCT_US |
| 94Z39NID6C | INXIGHT DRUGS |
Pharmaceutical products:
None