suprofen 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
anti-inflammatory agents, ibuprofen derivatives 2546 40828-46-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • suprofen
  • masterfen
  • (+/-)-Suprofen
  • profenol
  • racemic suprofen
  • sutoprofen
  • suprofen RS
An IBUPROFEN-type anti-inflammatory analgesic and antipyretic. It inhibits prostaglandin synthesis and has been proposed as an anti-arthritic.
  • Molecular weight: 260.31
  • Formula: C14H12O3S
  • CLOGP: 2.54
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 1
  • TPSA: 54.37
  • ALOGS: -3.79
  • ROTB: 4
  • Status: OFM
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.40 g O

ADMET properties:

PropertyValueReference
MRTD (Maximum Recommended Therapeutic Daily Dose) 65.86 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 92 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.04 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 0.76 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.01 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 2.10 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 -0.017 High 1
caco2-efflux Caco-2 efflux ratio (BA/AB) 0.993 High 1
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 82.604 10^-6 cm/s High 1
dh-clint Dog hepatocyte intrinsic clearance 10.328 uL/min/10^6 cells High 1
dppb Dog plasma protein binding (% unbound) 1.200 % High 1
fcs-ppb Fetal calf serum protein binding (% unbound) 4.660 % High 1
herg hERG pIC50 4.079 pIC50 High 1
hh-clint Human hepatocyte intrinsic clearance 8.375 uL/min/10^6 cells High 1
hlm-clint Human liver microsomal intrinsic clearance 4.831 uL/min/mg protein High 1
hppb Human plasma protein binding (% unbound) 0.990 % High 1
kinase-safety-class ACVR2B,AXL,BTK,CDK5,CDK9,EIF2AK3,ERBB2,GRK2,MAPK7,PDK1,PDK2,PDK4,PIK3CB,PIK3CG,PRKDC 15
kinase-selectivity-class AXL,EIF2AK3,GRK2,STK33,TEK,TTK 6
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 2.432 High 1
mh-clint Mouse hepatocyte intrinsic clearance 86.696 High 1
mppb Mouse plasma protein binding (% unbound) 8.610 High 1
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 0.605 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 1.790 % High 1
rh-clint Rat hepatocyte intrinsic clearance 9.572 uL/min/10^6 cells High 1
rh-fuinc Rat hepatocyte fraction unbound in incubation 94.760 % High 1
rppb Rat plasma protein binding (% unbound) 0.820 % High 1
solubility-dd Solubility at pH 7.4 in DMSO 952.796 uM High 1

Approvals:

DateAgencyCompanyOrphan
Dec. 23, 1988 FDA ALCON

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC M01AE07 MUSCULO-SKELETAL SYSTEM
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
Propionic acid derivatives
MeSH PA D000700 Analgesics
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000894 Anti-Inflammatory Agents, Non-Steroidal
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D016861 Cyclooxygenase Inhibitors
MeSH PA D018501 Antirheumatic Agents
MeSH PA D018689 Sensory System Agents
MeSH PA D018712 Analgesics, Non-Narcotic
CHEBI has role CHEBI:35475 non-steroidal anti-inflammatory drug
CHEBI has role CHEBI:35481 non-narcotic analgesic
CHEBI has role CHEBI:35544 EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor
CHEBI has role CHEBI:35842 antirheumatic drug
CHEBI has role CHEBI:49110 peripheral nervous system drug
CHEBI has role CHEBI:88188 drug allergen

Related Drugs by ATC class:

M01AE Propionic acid derivatives 21 drugs
alminoprofenbenoxaprofendexibuprofendexketoprofendiphenhydramineesomeprazolefenbufenfenoprofenflunoxaprofenflurbiprofenibuprofenibuproxam show all 21 →

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Herpes simplex dendritic keratitis contraindication 29943008
Blood coagulation disorder contraindication 64779008 DOID:1247




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.19 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Prostaglandin G/H synthase 2 Enzyme INHIBITOR IC50 5.06 WOMBAT-PK CHEMBL
Prostaglandin G/H synthase 1 Enzyme INHIBITOR IC50 5.96 WOMBAT-PK CHEMBL
Cytochrome P450 2C9 Enzyme Ki 4.35 WOMBAT-PK

External reference:

IDSource
4018481 VUID
N0000146803 NUI
D00452 KEGG_DRUG
4018481 VANDF
C0038878 UMLSCUI
CHEBI:9362 CHEBI
CHEMBL956 ChEMBL_ID
DB00870 DRUGBANK_ID
D013496 MESH_DESCRIPTOR_UI
5359 PUBCHEM_CID
7298 IUPHAR_LIGAND_ID
3586 INN_ID
988GU2F9PE UNII
10255 RXNORM
5537 MMSL
002393 NDDF
108849007 SNOMEDCT_US
398627003 SNOMEDCT_US

Pharmaceutical products:

None