pseudoephedrine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
sympathomimetics 2326 90-82-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • pseudoephedrine
  • (+)-Pseudoephedrine
  • pseudophedrine sulphate
  • pseudoephedrine hydrochloride
  • pseudoephedrine sulfate
  • pseudoephedrine HCl
  • pseudoephedrine polistirex
A phenethylamine that is an isomer of EPHEDRINE which has less central nervous system effects and usage is mainly for respiratory tract decongestion.
  • Molecular weight: 165.24
  • Formula: C10H15NO
  • CLOGP: 0.89
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 2
  • TPSA: 32.26
  • ALOGS: -1.30
  • ROTB: 3

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.24 g O
0.24 g O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 43 % Benet LZ, Broccatelli F, Oprea TI

Approvals:

DateAgencyCompanyOrphan
Oct. 18, 1963 FDA SCHERING PLOUGH

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pemphigus 2711.06 22.98 1905 77373 118261 50407585
Systemic lupus erythematosus 2523.93 22.98 1942 77336 138680 50387166
Pericarditis 2285.91 22.98 1461 77817 77228 50448618
Glossodynia 2282.76 22.98 1691 77587 113878 50411968
Hand deformity 2224.29 22.98 1574 77704 98625 50427221
Wound 2186.04 22.98 1591 77687 104203 50421643
Anti-cyclic citrullinated peptide antibody positive 1951.66 22.98 1271 78007 69316 50456530
Discomfort 1944.65 22.98 1498 77780 106882 50418964
Abdominal discomfort 1743.71 22.98 1971 77307 229670 50296176
Synovitis 1629.94 22.98 1430 77848 122435 50403411
Alopecia 1623.67 22.98 1953 77325 243094 50282752
Arthropathy 1591.61 22.98 1571 77707 156335 50369511
Swelling 1450.37 22.98 1674 77604 199198 50326648
Maternal exposure during pregnancy 1361.89 22.98 1453 77825 158325 50367521
Hepatic enzyme increased 1320.92 22.98 1333 77945 136047 50389799
Duodenal ulcer perforation 1305.25 22.98 840 78438 44771 50481075
Contraindicated product administered 1253.85 22.98 1346 77932 147612 50378234
Helicobacter infection 1246.61 22.98 843 78435 48859 50476987
Infusion related reaction 1224.34 22.98 1414 77864 168143 50357703
Rheumatoid factor positive 1070.82 22.98 769 78509 49090 50476756
Hypersensitivity 1058.04 22.98 1482 77796 213679 50312167
Drug intolerance 873.40 22.98 1368 77910 217736 50308110
Product use issue 865.71 22.98 1116 78162 148359 50377487
Joint swelling 804.81 22.98 1403 77875 243883 50281963
Therapeutic product effect decreased 662.46 22.98 934 78344 135116 50390730
Blister 614.12 22.98 712 78566 84706 50441140
Treatment failure 594.54 22.98 893 78385 136744 50389102
Muscle injury 573.57 22.98 471 78807 36640 50489206
Pain 570.78 22.98 2090 77188 576813 49949033
Folliculitis 565.11 22.98 478 78800 38747 50487099
Sleep disorder due to general medical condition, insomnia type 556.16 22.98 432 78846 31015 50494831
Irritable bowel syndrome 555.81 22.98 533 78745 50908 50474938
Rheumatic fever 550.52 22.98 338 78940 16529 50509317
Swollen joint count increased 516.14 22.98 310 78968 14563 50511283
Rheumatoid arthritis 508.04 22.98 1034 78244 201516 50324330
Rash 459.33 22.98 1614 77664 435857 50089989
Type 2 diabetes mellitus 367.02 22.98 354 78924 34021 50491825
Diarrhoea 348.53 22.98 250 79028 588226 49937620
Fall 342.56 22.98 57 79221 334875 50190971
Impaired healing 338.85 22.98 479 78799 69307 50456539
Nausea 337.00 22.98 367 78911 705031 49820815
Death 333.59 22.98 55 79223 325324 50200522
Hip arthroplasty 298.08 22.98 299 78979 30130 50495716
Anaemia 296.88 22.98 27 79251 252429 50273417
Blood cholesterol increased 292.01 22.98 395 78883 54820 50471026
Acute kidney injury 274.66 22.98 22 79256 228036 50297810
Stomatitis 251.77 22.98 516 78762 100828 50425018
Hypotension 249.82 22.98 36 79242 235433 50290413
Lower respiratory tract infection 230.90 22.98 480 78798 94721 50431125
Knee arthroplasty 227.95 22.98 281 78997 35565 50490281
Gastrointestinal disorder 224.13 22.98 472 78806 93984 50431862
Ill-defined disorder 223.24 22.98 346 78932 54308 50471538
Musculoskeletal stiffness 214.09 22.98 559 78719 127922 50397924
General physical health deterioration 202.80 22.98 585 78693 141849 50383997
Drug interaction 201.57 22.98 35 79243 199586 50326260
Pneumonia 198.15 22.98 181 79097 378220 50147626
Drug ineffective 192.39 22.98 2040 77238 817293 49708553
Asthenia 191.59 22.98 133 79145 318909 50206937
Cough 188.84 22.98 71 79207 241193 50284653
Urinary tract infection 182.00 22.98 62 79216 223958 50301888
Vomiting 174.12 22.98 284 78994 460474 50065372
Fatigue 171.99 22.98 1775 77503 705826 49820020
Live birth 167.61 22.98 165 79113 16243 50509603
Neutropenia 163.08 22.98 20 79258 147945 50377901
Product dose omission issue 150.81 22.98 50 79228 183788 50342058
Back pain 148.29 22.98 80 79198 219950 50305896
Intentional product use issue 144.03 22.98 350 78928 76568 50449278
Thrombocytopenia 141.32 22.98 17 79261 127656 50398190
Haemoglobin decreased 140.66 22.98 17 79261 127199 50398647
Sepsis 139.28 22.98 21 79257 132904 50392942
Dizziness 138.80 22.98 205 79073 346164 50179682
Malaise 132.09 22.98 201 79077 335331 50190515
Weight decreased 131.66 22.98 93 79185 221152 50304694
Somnolence 127.36 22.98 42 79236 154943 50370903
Constipation 124.40 22.98 68 79210 185640 50340206
Dehydration 120.64 22.98 44 79234 152405 50373441
Toxicity to various agents 120.39 22.98 94 79184 212405 50313441
Infection 120.24 22.98 563 78715 172391 50353455
Sinusitis 119.15 22.98 556 78722 170002 50355844
Febrile neutropenia 115.86 22.98 10 79268 97657 50428189
Pancytopenia 113.77 22.98 4 79274 84026 50441820
Renal failure 113.66 22.98 16 79262 106617 50419229
Erythema 111.30 22.98 45 79233 146369 50379477
Hyponatraemia 110.95 22.98 11 79267 96128 50429718
Atrial fibrillation 109.08 22.98 15 79263 101730 50424116
Abdominal pain 107.62 22.98 127 79151 236101 50289745
Disease progression 105.49 22.98 13 79265 95853 50429993
Contusion 105.03 22.98 400 78878 111783 50414063
Injury 103.98 22.98 234 79044 48691 50477155
Drug tolerance decreased 100.85 22.98 96 79182 9064 50516782
Injection site pain 100.58 22.98 25 79253 110999 50414847
White blood cell count decreased 98.78 22.98 30 79248 116692 50409154
Adverse event 96.01 22.98 212 79066 43551 50482295
Cardiac failure 95.28 22.98 6 79272 76034 50449812
Renal impairment 94.71 22.98 6 79272 75655 50450191
Gastrointestinal haemorrhage 91.23 22.98 6 79272 73315 50452531
Myalgia 90.02 22.98 41 79237 124278 50401568
Malignant neoplasm progression 89.65 22.98 4 79274 68120 50457726
Platelet count decreased 88.71 22.98 24 79254 100702 50425144
Oxygen saturation decreased 88.25 22.98 7 79271 73241 50452605
Pain in extremity 83.76 22.98 190 79088 272675 50253171
Hypokalaemia 83.30 22.98 18 79260 87974 50437872
Blood pressure increased 83.11 22.98 53 79225 133079 50392767
Leukopenia 82.63 22.98 6 79272 67522 50458324
Blood creatinine increased 82.16 22.98 11 79267 76149 50449697
Oropharyngeal pain 82.14 22.98 12 79266 77789 50448057
Tremor 81.49 22.98 39 79239 114864 50410982
Respiratory failure 79.78 22.98 22 79256 91159 50434687
Myocardial infarction 78.80 22.98 21 79257 89006 50436840
Bradycardia 78.05 22.98 6 79272 64420 50461426
Herpes zoster 76.90 22.98 10 79268 70776 50455070
Syncope 76.09 22.98 33 79245 102969 50422877
Inappropriate schedule of product administration 76.02 22.98 11 79267 71820 50454026
Arthralgia 75.56 22.98 1032 78246 437670 50088176
Seizure 74.85 22.98 46 79232 117828 50408018
Neuropathy peripheral 73.08 22.98 30 79248 96727 50429119
Condition aggravated 72.86 22.98 748 78530 296310 50229536
Cerebrovascular accident 72.08 22.98 29 79249 94651 50431195
Completed suicide 71.33 22.98 61 79217 131828 50394018
Hypoglycaemia 70.99 22.98 3 79275 53578 50472268
Pleural effusion 70.62 22.98 20 79258 81434 50444412
Balance disorder 69.82 22.98 13 79265 70577 50455269
Cardiac failure congestive 69.05 22.98 23 79255 84359 50441487
Confusional state 68.38 22.98 512 78766 185416 50340430
Liver injury 68.33 22.98 132 79146 24674 50501172
Nasopharyngitis 66.89 22.98 524 78754 192403 50333443
Multiple organ dysfunction syndrome 66.09 22.98 3 79275 50334 50475512
Alanine aminotransferase increased 65.75 22.98 28 79250 88331 50437515
Influenza 65.64 22.98 29 79249 89509 50436337
Psoriasis 65.54 22.98 14 79264 68986 50456860
Chest discomfort 64.93 22.98 32 79246 92690 50433156
Septic shock 64.77 22.98 7 79271 57168 50468678
Blood glucose increased 64.70 22.98 16 79262 71308 50454538
Loss of consciousness 64.49 22.98 42 79236 104311 50421535
Injection site erythema 63.86 22.98 19 79259 74917 50450929
Tachycardia 63.24 22.98 39 79239 99724 50426122
Hyperkalaemia 62.70 22.98 3 79275 48086 50477760
Adverse drug reaction 61.96 22.98 209 79069 55013 50470833
Oedema peripheral 61.66 22.98 95 79183 157866 50367980
Aspartate aminotransferase increased 60.84 22.98 23 79255 77975 50447871
Chills 58.29 22.98 40 79238 96647 50429199
Overdose 57.84 22.98 43 79235 99684 50426162
Dyspnoea exertional 56.22 22.98 7 79271 51226 50474620
Influenza like illness 53.87 22.98 12 79266 57447 50468399
Blood pressure decreased 53.80 22.98 11 79267 55898 50469948
Cellulitis 53.37 22.98 22 79256 70776 50455070
Wrong technique in product usage process 53.26 22.98 11 79267 55499 50470347
Hyperhidrosis 52.58 22.98 38 79240 89388 50436458
Electrocardiogram QT prolonged 52.51 22.98 9 79269 51877 50473969
Dislocation of vertebra 51.48 22.98 41 79237 3046 50522800
Epistaxis 51.33 22.98 18 79260 63936 50461910
Abdominal distension 51.28 22.98 25 79253 72878 50452968
Anxiety 51.00 22.98 128 79150 177478 50348368
Fluid retention 50.79 22.98 9 79269 50640 50475206
Mucosal inflammation 50.78 22.98 3 79275 40139 50485707
Depressed level of consciousness 50.46 22.98 10 79268 51943 50473903
Adjustment disorder with depressed mood 50.44 22.98 39 79239 2775 50523071
Insomnia 50.23 22.98 126 79152 174739 50351107
Weight increased 50.19 22.98 510 78768 201381 50324465
Bronchitis 49.54 22.98 54 79224 104105 50421741
Breast cancer 49.23 22.98 5 79273 42885 50482961
Exposure during pregnancy 48.92 22.98 341 78937 120674 50405172
Peripheral swelling 48.72 22.98 515 78763 205421 50320425
Flushing 48.65 22.98 22 79256 66993 50458853
Intentional overdose 47.80 22.98 19 79259 62485 50463361
Productive cough 47.44 22.98 12 79266 52682 50473164
Cardiac arrest 47.31 22.98 37 79241 83614 50442232
Retinitis 47.18 22.98 32 79246 1855 50523991
Vision blurred 46.79 22.98 33 79245 78614 50447232
Feeling abnormal 46.58 22.98 78 79200 125414 50400432
Haemorrhage 46.54 22.98 13 79265 53428 50472418
Therapeutic product effect incomplete 46.29 22.98 45 79233 91470 50434376
Depression 46.12 22.98 121 79157 165302 50360544
Pregnancy 45.43 22.98 125 79153 29452 50496394
Decreased appetite 45.31 22.98 162 79116 200761 50325085
Hospitalisation 45.26 22.98 25 79253 67912 50457934
Injection site swelling 45.13 22.98 6 79272 41767 50484079
Vertigo 44.41 22.98 13 79265 51819 50474027
Pancreatitis 44.00 22.98 7 79271 42607 50483239
Heart rate increased 43.90 22.98 34 79244 77216 50448630
Pulmonary embolism 43.80 22.98 57 79221 101647 50424199
Blood pressure systolic increased 43.80 22.98 3 79275 35446 50490400
Rhabdomyolysis 43.64 22.98 5 79273 39022 50486824
Metabolic acidosis 43.35 22.98 5 79273 38820 50487026
Cystitis 42.40 22.98 9 79269 44555 50481291
Neutrophil count decreased 42.37 22.98 10 79268 46016 50479830
Chest pain 42.33 22.98 139 79139 176743 50349103
Hypoxia 41.70 22.98 14 79264 51109 50474737
Lethargy 41.27 22.98 13 79265 49419 50476427
Rash pruritic 41.00 22.98 12 79266 47834 50478012
Headache 40.83 22.98 554 78724 505981 50019865
Abortion spontaneous 40.65 22.98 8 79270 41764 50484082
Cardiac disorder 40.24 22.98 9 79269 42970 50482876
Heart rate decreased 40.01 22.98 5 79273 36492 50489354
Palpitations 39.65 22.98 54 79224 94452 50431394
Chronic obstructive pulmonary disease 39.64 22.98 17 79261 53418 50472428
Thrombosis 39.49 22.98 19 79259 55814 50470032
White blood cell count increased 39.24 22.98 9 79269 42231 50483615
Ascites 39.10 22.98 5 79273 35856 50489990
Speech disorder 38.65 22.98 5 79273 35543 50490303
Cardio-respiratory arrest 38.64 22.98 18 79260 53874 50471972
Disorientation 38.56 22.98 5 79273 35479 50490367
Drug abuse 38.47 22.98 23 79255 59823 50466023
Bone pain 38.41 22.98 13 79265 47216 50478630
Multiple sclerosis relapse 38.26 22.98 10 79268 42954 50482892
Paraesthesia 38.25 22.98 82 79196 120161 50405685
Incorrect dose administered 38.22 22.98 14 79264 48400 50477446
Liver function test abnormal 38.21 22.98 11 79267 44328 50481518
Lactic acidosis 37.99 22.98 4 79274 33351 50492495
Muscle spasms 37.99 22.98 88 79190 125465 50400381
Suicide attempt 37.52 22.98 17 79261 51715 50474131
Dysphagia 37.06 22.98 40 79238 77478 50448368
Hepatic function abnormal 37.01 22.98 4 79274 32677 50493169
Prescribed overdose 36.96 22.98 75 79203 14525 50511321
Femur fracture 36.82 22.98 7 79271 37457 50488389
Injection site pruritus 36.77 22.98 9 79269 40402 50485444
Rectal haemorrhage 36.25 22.98 8 79270 38550 50487296
Dyspnoea 36.25 22.98 622 78656 546986 49978860
Pain in jaw 36.07 22.98 8 79270 38420 50487426
Suicidal ideation 36.00 22.98 21 79257 55364 50470482
Seronegative arthritis 35.72 22.98 28 79250 2033 50523813
Pulmonary hypertension 35.62 22.98 5 79273 33412 50492434
Hyperglycaemia 35.36 22.98 7 79271 36398 50489448
Plasma cell myeloma 35.05 22.98 4 79274 31318 50494528
Coma 34.98 22.98 23 79255 56856 50468990
Skin discolouration 34.69 22.98 5 79273 32752 50493094
Dysarthria 34.68 22.98 8 79270 37395 50488451
Osteonecrosis of jaw 34.36 22.98 5 79273 32521 50493325
Pulmonary oedema 34.08 22.98 17 79261 48921 50476925
Red blood cell count decreased 33.95 22.98 6 79272 33829 50492017
Respiratory distress 33.86 22.98 4 79274 30485 50495361
Upper respiratory tract infection 33.79 22.98 32 79246 65866 50459980
Agitation 33.64 22.98 21 79257 53363 50472483
Prescribed underdose 33.55 22.98 76 79202 15873 50509973
X-ray abnormal 33.47 22.98 30 79248 2622 50523224
Angioedema 33.11 22.98 9 79269 37667 50488179
Burning sensation 32.86 22.98 15 79263 45431 50480415
Hepatitis 32.85 22.98 5 79273 31448 50494398
Anti-cyclic citrullinated peptide antibody 32.84 22.98 24 79254 1568 50524278
Mobility decreased 32.71 22.98 226 79052 79722 50446124
Blood pressure fluctuation 32.55 22.98 8 79270 35815 50490031
Haematemesis 32.43 22.98 3 79275 27722 50498124
Hepatic failure 31.80 22.98 6 79272 32277 50493569
Gastrooesophageal reflux disease 31.72 22.98 44 79234 76384 50449462
Encephalopathy 31.68 22.98 7 79271 33704 50492142
Sedation 31.66 22.98 5 79273 30605 50495241
International normalised ratio increased 31.58 22.98 14 79264 43138 50482708
Acute respiratory failure 31.41 22.98 4 79274 28778 50497068
Rash erythematous 31.25 22.98 8 79270 34844 50491002
Surgery 31.09 22.98 5 79273 30200 50495646
C-reactive protein increased 31.01 22.98 35 79243 66439 50459407
Asthma 30.91 22.98 58 79220 89279 50436567
Haematochezia 30.70 22.98 12 79266 39870 50485976
Cataract 30.65 22.98 18 79260 47282 50478564
Blood potassium decreased 30.34 22.98 10 79268 36935 50488911
Mouth ulceration 30.33 22.98 4 79274 28020 50497826
Injection site bruising 30.11 22.98 10 79268 36758 50489088
Muscular weakness 30.04 22.98 65 79213 94948 50430898
Skin ulcer 30.00 22.98 9 79269 35309 50490537
Hepatocellular injury 29.84 22.98 3 79275 25944 50499902
Acute myocardial infarction 29.79 22.98 5 79273 29268 50496578
Lymphadenopathy 29.44 22.98 8 79270 33491 50492355
Hepatotoxicity 29.20 22.98 4 79274 27222 50498624
Unevaluable event 29.19 22.98 18 79260 46048 50479798
Localised infection 29.17 22.98 3 79275 25482 50500364
Maternal exposure timing unspecified 29.05 22.98 32 79246 3588 50522258
Diverticulitis 29.02 22.98 8 79270 33174 50492672
Throat irritation 28.99 22.98 6 79272 30233 50495613
Musculoskeletal pain 28.53 22.98 43 79235 72134 50453712
Body temperature increased 28.48 22.98 7 79271 31334 50494512
Dyskinesia 27.82 22.98 5 79273 27856 50497990
Transaminases increased 27.77 22.98 5 79273 27819 50498027
Blood alkaline phosphatase increased 27.73 22.98 12 79266 37514 50488332
No adverse event 27.73 22.98 9 79269 33569 50492277
Deep vein thrombosis postoperative 27.52 22.98 22 79256 1643 50524203
Therapy cessation 27.47 22.98 4 79274 26007 50499839
Colitis 27.41 22.98 13 79265 38516 50487330
Haematoma 27.36 22.98 7 79271 30503 50495343
Device expulsion 27.05 22.98 6 79272 28816 50497030
Interstitial lung disease 27.05 22.98 26 79252 53150 50472696
Cognitive disorder 26.92 22.98 18 79260 44105 50481741
Pericardial effusion 26.88 22.98 4 79274 25585 50500261
Fungal infection 26.63 22.98 7 79271 29958 50495888
Depressed mood 26.58 22.98 10 79268 34013 50491833
Stress 26.56 22.98 27 79251 53766 50472080
Rhinorrhoea 26.50 22.98 25 79253 51558 50474288
Drug eruption 26.45 22.98 3 79275 23603 50502243
Dysphonia 26.35 22.98 14 79264 38878 50486968
Skin lesion 26.25 22.98 5 79273 26722 50499124
Mental status changes 26.18 22.98 12 79266 36260 50489586
Pneumonia aspiration 26.15 22.98 8 79270 30996 50494850
Basal cell carcinoma 26.09 22.98 3 79275 23353 50502493
Skin exfoliation 26.06 22.98 10 79268 33602 50492244
Arthritis 26.05 22.98 61 79217 86660 50439186
Intentional product misuse 26.01 22.98 21 79257 46713 50479133
Injection site reaction 25.99 22.98 24 79254 50008 50475838
Gastroenteritis 25.99 22.98 3 79275 23278 50502568
Chronic kidney disease 25.96 22.98 15 79263 39756 50486090
Transient ischaemic attack 25.96 22.98 9 79269 32201 50493645
Jaundice 25.84 22.98 5 79273 26424 50499422
Accidental exposure to product 25.66 22.98 3 79275 23054 50502792
Urinary retention 25.51 22.98 5 79273 26185 50499661
Hypothyroidism 25.08 22.98 11 79267 34114 50491732
Dysgeusia 24.95 22.98 15 79263 38901 50486945
Breast cancer stage III 24.78 22.98 28 79250 3228 50522618
Haemoptysis 24.67 22.98 5 79273 25568 50500278
Cerebral haemorrhage 24.66 22.98 6 79272 27046 50498800
Respiratory disorder 24.64 22.98 9 79269 31178 50494668
Drug reaction with eosinophilia and systemic symptoms 24.59 22.98 7 79271 28417 50497429
Haematocrit decreased 24.58 22.98 12 79266 34964 50490882
Neoplasm malignant 24.24 22.98 4 79274 23711 50502135
Pneumonitis 24.21 22.98 8 79270 29502 50496344
Orthostatic hypotension 24.17 22.98 8 79270 29473 50496373
Facet joint syndrome 24.14 22.98 24 79254 2389 50523457
Deep vein thrombosis 24.13 22.98 49 79229 73255 50452591
Rash maculo-papular 24.11 22.98 6 79272 26635 50499211
Blood urea increased 24.06 22.98 4 79274 23581 50502265
Respiratory tract infection 24.04 22.98 10 79268 32007 50493839
Feeling hot 23.91 22.98 16 79262 39186 50486660
Staphylococcal infection 23.87 22.98 13 79265 35603 50490243
Blood creatine phosphokinase increased 23.74 22.98 6 79272 26361 50499485
Hypophagia 23.67 22.98 7 79271 27721 50498125
Gastritis 23.67 22.98 11 79267 32972 50492874
Lymphocyte count decreased 23.66 22.98 6 79272 26301 50499545
Grip strength decreased 23.56 22.98 56 79222 12065 50513781
Lip dry 23.40 22.98 33 79245 4754 50521092
Renal disorder 23.38 22.98 7 79271 27498 50498348
Hot flush 23.17 22.98 21 79257 44148 50481698
Hip fracture 23.16 22.98 6 79272 25925 50499921
Therapeutic response decreased 22.99 22.98 24 79254 47207 50478639

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Sudden infant death syndrome 65.67 15.51 13 5007 168 29569339
Cardiac septal defect 55.84 15.51 12 5008 237 29569270
Kidney duplex 49.94 15.51 12 5008 396 29569111
Toxicity to various agents 43.74 15.51 93 4927 173568 29395939
Substance abuser 29.99 15.51 6 5014 82 29569425
Hypoxic-ischaemic encephalopathy 25.23 15.51 13 5007 4271 29565236
Tachycardia 18.40 15.51 39 4981 72371 29497136
Nasal congestion 18.05 15.51 19 5001 18860 29550647

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pemphigus 2194.32 19.40 1073 56486 59628 64381545
Systemic lupus erythematosus 2050.93 19.40 1111 56448 76501 64364672
Pericarditis 2002.17 19.40 1018 56541 61498 64379675
Glossodynia 1874.48 19.40 985 56574 63711 64377462
Hand deformity 1802.27 19.40 950 56609 61821 64379352
Anti-cyclic citrullinated peptide antibody positive 1783.99 19.40 874 56685 48688 64392485
Wound 1647.91 19.40 958 56601 75519 64365654
Discomfort 1505.23 19.40 922 56637 79956 64361217
Synovitis 1431.63 19.40 963 56596 98127 64343046
Arthropathy 1298.58 19.40 981 56578 119986 64321187
Alopecia 1281.51 19.40 1109 56450 164581 64276592
Duodenal ulcer perforation 1276.30 19.40 621 56938 34004 64407169
Abdominal discomfort 1240.67 19.40 1135 56424 181187 64259986
Helicobacter infection 1227.60 19.40 625 56934 37737 64403436
Swelling 1116.09 19.40 1011 56548 159207 64281966
Hepatic enzyme increased 1102.87 19.40 918 56641 129025 64312148
Maternal exposure during pregnancy 1033.57 19.40 780 56779 95104 64346069
Hypersensitivity 991.68 19.40 1039 56520 195413 64245760
Contraindicated product administered 971.52 19.40 789 56770 107040 64334133
Infusion related reaction 948.52 19.40 935 56624 163532 64277641
Rheumatoid factor positive 868.02 19.40 481 57078 34457 64406716
Drug intolerance 835.59 19.40 930 56629 187062 64254111
Joint swelling 771.68 19.40 954 56605 214428 64226745
Irritable bowel syndrome 768.95 19.40 455 57104 36914 64404259
Muscle injury 759.88 19.40 401 57158 26036 64415137
Folliculitis 724.96 19.40 406 57153 29671 64411502
Blister 723.54 19.40 590 56969 80377 64360796
Therapeutic product effect decreased 707.76 19.40 679 56880 114672 64326501
Sleep disorder due to general medical condition, insomnia type 691.93 19.40 376 57183 25894 64415279
Rheumatoid arthritis 478.81 19.40 658 56901 163636 64277537
Impaired healing 474.43 19.40 409 57150 60064 64381109
Treatment failure 432.78 19.40 527 57032 116289 64324884
Product use issue 418.61 19.40 592 56967 151123 64290050
Pain 402.04 19.40 1242 56317 552269 63888904
Rheumatic fever 348.95 19.40 169 57390 9125 64432048
Stomatitis 344.92 19.40 456 57103 109149 64332024
Rash 338.99 19.40 1036 56523 457513 63983660
Lower respiratory tract infection 321.65 19.40 409 57150 94205 64346968
Gastrointestinal disorder 319.61 19.40 397 57162 89312 64351861
Swollen joint count increased 310.51 19.40 147 57412 7542 64433631
Ill-defined disorder 305.60 19.40 278 57281 43774 64397399
Acute kidney injury 294.33 19.40 30 57529 449210 63991963
Sinusitis 268.34 19.40 473 57086 145455 64295718
Hip arthroplasty 248.01 19.40 182 57377 21169 64420004
Anaemia 241.04 19.40 28 57531 378652 64062521
Infection 203.85 19.40 485 57074 184395 64256778
Death 196.20 19.40 93 57466 482612 63958561
Fall 196.17 19.40 64 57495 416762 64024411
Knee arthroplasty 194.30 19.40 174 57385 26825 64414348
Pneumonia 190.26 19.40 134 57425 559442 63881731
Type 2 diabetes mellitus 189.02 19.40 190 57369 33830 64407343
Hypotension 183.69 19.40 56 57503 380918 64060255
Diarrhoea 179.30 19.40 230 57329 722474 63718699
Nausea 171.37 19.40 274 57285 785526 63655647
Blood cholesterol increased 170.88 19.40 217 57342 49849 64391324
Drug interaction 166.12 19.40 58 57501 362025 64079148
Musculoskeletal stiffness 161.10 19.40 346 57213 122860 64318313
Contusion 157.05 19.40 327 57232 113638 64327535
Nasopharyngitis 141.32 19.40 440 57119 195633 64245540
Neutropenia 135.49 19.40 25 57534 239599 64201574
Arthralgia 132.52 19.40 758 56801 441502 63999671
Thrombocytopenia 131.70 19.40 21 57538 223780 64217393
Adverse event 129.77 19.40 168 57391 39321 64401852
Fatigue 127.45 19.40 1118 56441 747612 63693561
Drug ineffective 120.71 19.40 1210 56349 839037 63602136
Weight increased 120.36 19.40 441 57118 212907 64228266
Sepsis 118.09 19.40 30 57529 230311 64210862
Peripheral swelling 116.02 19.40 430 57129 208723 64232450
Injury 113.91 19.40 190 57369 55802 64385371
Live birth 111.27 19.40 87 57472 11117 64430056
Pregnancy 111.26 19.40 114 57445 20751 64420422
Febrile neutropenia 109.51 19.40 18 57541 187639 64253534
Vomiting 107.27 19.40 206 57353 550911 63890262
Pancytopenia 106.81 19.40 5 57554 143304 64297869
Asthenia 100.97 19.40 141 57418 427903 64013270
Cough 97.72 19.40 76 57483 302072 64139101
Renal failure 96.37 19.40 22 57537 181666 64259507
Intentional product use issue 96.23 19.40 242 57317 95122 64346051
Haemoglobin decreased 95.10 19.40 28 57531 195035 64246138
Cardiac failure 91.46 19.40 7 57552 132366 64308807
Platelet count decreased 89.56 19.40 20 57539 167691 64273482
Exposure during pregnancy 87.85 19.40 206 57353 77469 64363704
Hyponatraemia 87.05 19.40 14 57545 148325 64292848
Urinary tract infection 84.52 19.40 51 57508 231545 64209628
Renal impairment 83.26 19.40 11 57548 135006 64306167
Adverse drug reaction 79.07 19.40 144 57415 45320 64395853
Confusional state 77.59 19.40 447 57112 260697 64180476
Disease progression 77.47 19.40 16 57543 141664 64299509
Bradycardia 76.95 19.40 8 57551 118211 64322962
Somnolence 76.92 19.40 43 57516 203602 64237571
Dehydration 74.63 19.40 51 57508 216712 64224461
Malignant neoplasm progression 72.54 19.40 8 57551 112863 64328310
Atrial fibrillation 72.38 19.40 31 57528 171058 64270115
Pruritus 71.88 19.40 501 57058 311899 64129274
Septic shock 71.65 19.40 6 57553 105431 64335742
General physical health deterioration 71.56 19.40 366 57193 204059 64237114
Multiple organ dysfunction syndrome 71.09 19.40 5 57554 101408 64339765
White blood cell count decreased 71.04 19.40 26 57533 157811 64283362
Hyperkalaemia 70.85 19.40 5 57554 101124 64340049
Gastrointestinal haemorrhage 70.19 19.40 16 57543 132296 64308877
Sudden infant death syndrome 68.02 19.40 18 57541 153 64441020
Respiratory failure 66.93 19.40 30 57529 161153 64280020
Constipation 66.44 19.40 64 57495 229273 64211900
Oxygen saturation decreased 65.44 19.40 9 57550 107167 64334006
Blood creatinine increased 65.23 19.40 20 57539 135762 64305411
Weight decreased 64.46 19.40 97 57462 285642 64155531
Erythema 64.40 19.40 44 57515 187026 64254147
Hypoglycaemia 64.28 19.40 4 57555 89888 64351285
Adjustment disorder with depressed mood 64.16 19.40 35 57524 2422 64438751
Leukopenia 63.01 19.40 8 57551 101234 64339939
Myocardial infarction 62.63 19.40 35 57524 165786 64275387
Dislocation of vertebra 61.47 19.40 37 57522 3087 64438086
Cardiac failure congestive 61.36 19.40 20 57539 130560 64310613
Product dose omission issue 60.40 19.40 51 57508 194696 64246477
Rhabdomyolysis 60.23 19.40 6 57553 91720 64349453
Retinitis 58.07 19.40 31 57528 2054 64439119
Hypokalaemia 56.70 19.40 19 57540 121884 64319289
Back pain 55.38 19.40 86 57473 250085 64191088
Abdominal pain 53.71 19.40 125 57434 312250 64128923
Maternal exposure timing unspecified 53.10 19.40 32 57527 2675 64438498
Alanine aminotransferase increased 50.15 19.40 31 57528 139000 64302173
Blood pressure increased 50.13 19.40 48 57511 172504 64268669
Inappropriate schedule of product administration 49.26 19.40 11 57548 92275 64348898
Pain in extremity 49.18 19.40 125 57434 302960 64138213
Pleural effusion 48.82 19.40 26 57533 126533 64314640
Syncope 47.99 19.40 42 57517 157593 64283580
Fibromyalgia 46.23 19.40 100 57459 35631 64405542
Injection site pain 45.82 19.40 21 57538 111387 64329786
Metabolic acidosis 45.66 19.40 5 57554 70953 64370220
Aspartate aminotransferase increased 45.63 19.40 25 57534 119763 64321410
Hepatic function abnormal 45.57 19.40 3 57556 64310 64376863
Oropharyngeal pain 44.68 19.40 12 57547 88855 64352318
Herpes zoster 43.15 19.40 9 57550 79178 64361995
Malaise 42.77 19.40 195 57364 396052 64045121
Seronegative arthritis 42.69 19.40 28 57531 2715 64438458
Neuropathy peripheral 42.67 19.40 26 57533 117499 64323674
Seizure 42.30 19.40 52 57507 166840 64274333
Off label use 42.10 19.40 362 57197 632444 63808729
COVID-19 40.89 19.40 5 57554 65135 64376038
Toxicity to various agents 40.36 19.40 177 57382 363336 64077837
Lactic acidosis 40.36 19.40 4 57555 61406 64379767
Tremor 39.92 19.40 44 57515 148186 64292987
Blood glucose increased 39.54 19.40 19 57540 98054 64343119
Depressed level of consciousness 39.09 19.40 12 57547 81424 64359749
Chest discomfort 39.03 19.40 28 57531 116078 64325095
Prescribed overdose 38.69 19.40 67 57492 20264 64420909
Myalgia 38.56 19.40 51 57508 158566 64282607
Influenza 38.08 19.40 24 57535 106507 64334666
Loss of consciousness 37.84 19.40 46 57513 148319 64292854
Dizziness 37.83 19.40 227 57332 429936 64011237
Neutrophil count decreased 37.74 19.40 11 57548 77185 64363988
Blood pressure decreased 37.44 19.40 15 57544 86184 64354989
Hypoxia 37.22 19.40 16 57543 88133 64353040
Dyspnoea exertional 36.98 19.40 10 57549 73720 64367453
Anti-cyclic citrullinated peptide antibody 36.96 19.40 20 57539 1362 64439811
Mucosal inflammation 36.49 19.40 6 57553 62578 64378595
Cellulitis 36.47 19.40 19 57540 93638 64347535
Condition aggravated 35.98 19.40 498 57061 371928 64069245
Electrocardiogram QT prolonged 35.88 19.40 13 57546 79435 64361738
Epistaxis 35.22 19.40 22 57537 98109 64343064
Haematuria 34.81 19.40 6 57553 60465 64380708
Cerebrovascular accident 34.72 19.40 43 57516 137540 64303633
Breast cancer stage III 34.25 19.40 25 57534 2880 64438293
Wrong technique in product usage process 34.16 19.40 8 57551 64966 64376207
International normalised ratio increased 34.02 19.40 14 57545 79153 64362020
Ascites 33.88 19.40 7 57552 61994 64379179
Abdominal distension 33.79 19.40 22 57537 95972 64345201
Rectal haemorrhage 33.74 19.40 7 57552 61810 64379363
Psoriasis 33.64 19.40 11 57548 71692 64369481
Productive cough 33.02 19.40 12 57547 73191 64367982
Haemorrhage 32.56 19.40 15 57544 79336 64361837
Blood bilirubin increased 32.50 19.40 6 57553 57547 64383626
Pneumonia aspiration 31.76 19.40 7 57552 59264 64381909
Oedema peripheral 31.62 19.40 90 57469 210227 64230946
Deep vein thrombosis postoperative 31.62 19.40 18 57541 1353 64439820
Mobility decreased 31.61 19.40 156 57403 85684 64355489
Chills 31.49 19.40 46 57513 137218 64303955
Liver injury 31.25 19.40 77 57482 29855 64411318
Cardiac arrest 31.25 19.40 56 57503 154008 64287165
Disorientation 31.14 19.40 6 57553 55822 64385351
Interstitial lung disease 31.01 19.40 25 57534 97707 64343466
Pulmonary oedema 30.57 19.40 16 57543 78658 64362515
Haemoptysis 30.21 19.40 4 57555 49044 64392129
Drug tolerance decreased 29.87 19.40 34 57525 6964 64434209
Grip strength decreased 29.67 19.40 44 57515 11680 64429493
Hepatocellular injury 29.58 19.40 3 57556 45232 64395941
White blood cell count increased 29.47 19.40 11 57548 66003 64375170
Encephalopathy 29.46 19.40 8 57551 58811 64382362
Walking aid user 29.36 19.40 32 57527 6249 64434924
Melaena 29.35 19.40 6 57553 53542 64387631
Drug abuse 28.79 19.40 46 57513 132328 64308845
Respiratory distress 28.40 19.40 6 57553 52325 64388848
Dysarthria 28.07 19.40 9 57550 59397 64381776
Drug reaction with eosinophilia and systemic symptoms 27.87 19.40 7 57552 54210 64386963
Pulmonary hypertension 27.85 19.40 3 57556 43136 64398037
Vertigo 27.78 19.40 9 57550 59002 64382171
Pancreatitis acute 27.62 19.40 3 57556 42852 64398321
Gamma-glutamyltransferase increased 27.51 19.40 5 57554 48505 64392668
Hepatitis 27.41 19.40 4 57555 45578 64395595
Balance disorder 27.22 19.40 21 57538 83905 64357268
Chronic obstructive pulmonary disease 26.80 19.40 15 57544 71033 64370140
Heart rate decreased 26.64 19.40 8 57551 55059 64386114
Acute respiratory failure 26.54 19.40 6 57553 49928 64391245
Fluid retention 26.50 19.40 10 57549 59596 64381577
Lip dry 26.45 19.40 27 57532 4891 64436282
Facet joint syndrome 26.14 19.40 18 57541 1891 64439282
Coma 25.87 19.40 24 57535 87591 64353582
Hyperglycaemia 25.84 19.40 11 57548 60957 64380216
Red blood cell count decreased 25.35 19.40 6 57553 48380 64392793
Osteonecrosis of jaw 25.13 19.40 3 57556 39822 64401351
Pancreatitis 24.87 19.40 11 57548 59596 64381577
Influenza like illness 24.80 19.40 12 57547 61690 64379483
Tachycardia 24.76 19.40 61 57498 149518 64291655
Haematemesis 24.29 19.40 6 57553 46993 64394180
Blood pressure fluctuation 24.26 19.40 8 57551 51863 64389310
Blood pressure systolic increased 24.26 19.40 7 57552 49446 64391727
Blood creatine phosphokinase increased 24.13 19.40 11 57548 58547 64382626
Injection site erythema 23.88 19.40 17 57542 70783 64370390
Agranulocytosis 23.83 19.40 3 57556 38226 64402947
Thrombosis 23.78 19.40 17 57542 70625 64370548
Plasma cell myeloma 23.58 19.40 6 57553 46069 64395104
Lymphocyte count decreased 23.51 19.40 4 57555 40695 64400478
Exostosis 23.49 19.40 39 57520 11399 64429774
Hepatic failure 23.47 19.40 10 57549 55384 64385789
Spinal fusion surgery 23.28 19.40 22 57537 3629 64437544
Hypomagnesaemia 23.14 19.40 3 57556 37373 64403800
Toxic epidermal necrolysis 22.97 19.40 3 57556 37163 64404010
Heart rate increased 22.70 19.40 33 57526 98642 64342531
Incorrect dose administered 22.68 19.40 13 57546 60752 64380421
Completed suicide 22.67 19.40 113 57446 224301 64216872
Pulmonary embolism 22.46 19.40 62 57497 146294 64294879
Skin lesion 22.41 19.40 3 57556 36479 64404694
Blood urea increased 22.12 19.40 6 57553 44147 64397026
Cerebral haemorrhage 22.00 19.40 9 57550 51081 64390092
Liver function test abnormal 21.75 19.40 13 57546 59388 64381785
Flushing 21.55 19.40 23 57536 78625 64362548
Hyperhidrosis 21.42 19.40 50 57509 124870 64316303
Lethargy 21.29 19.40 20 57539 72574 64368599
Lupus-like syndrome 20.84 19.40 32 57527 8759 64432414
Transaminases increased 20.64 19.40 7 57552 44587 64396586
Rash pruritic 20.41 19.40 13 57546 57391 64383782
Jaundice 20.17 19.40 9 57550 48503 64392670
Haematoma 20.16 19.40 8 57551 46242 64394931
Colitis 19.91 19.40 14 57545 58660 64382513
Haematochezia 19.81 19.40 18 57541 66355 64374818
C-reactive protein increased 19.69 19.40 34 57525 94875 64346298
Blood alkaline phosphatase increased 19.67 19.40 13 57546 56266 64384907
Acute myocardial infarction 19.53 19.40 20 57539 69698 64371475
Decreased appetite 19.49 19.40 159 57400 281130 64160043

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC R01BA02 RESPIRATORY SYSTEM
NASAL PREPARATIONS
NASAL DECONGESTANTS FOR SYSTEMIC USE
Sympathomimetics
ATC R01BA52 RESPIRATORY SYSTEM
NASAL PREPARATIONS
NASAL DECONGESTANTS FOR SYSTEMIC USE
Sympathomimetics
FDA MoA N0000000209 Adrenergic alpha-Agonists
FDA EPC N0000175552 alpha-Adrenergic Agonist
CHEBI has role CHEBI:35470 central nervous system agents
CHEBI has role CHEBI:35523 bronchodilator
CHEBI has role CHEBI:35524 sympathomimetic
CHEBI has role CHEBI:35703 Xenobiotic
CHEBI has role CHEBI:49167 anti-asthmatic drugs
CHEBI has role CHEBI:76924 plant metabolites
CHEBI has role CHEBI:77715 nasal decongestants
MeSH PA D018927 Anti-Asthmatic Agents
MeSH PA D001993 Bronchodilator Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D014663 Nasal Decongestants
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D019141 Respiratory System Agents
MeSH PA D014662 Vasoconstrictor Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Sinus headache indication 4969004
Vasomotor rhinitis indication 8229003 DOID:4730
Allergic rhinitis indication 61582004
Nasal discharge indication 64531003
Nasal congestion indication 68235000
Rhinitis indication 70076002 DOID:4483
Common cold indication 82272006 DOID:10459
Headache disorder indication 230461009
Influenza-like symptoms indication 315642008
Seasonal allergic rhinitis indication 367498001
Allergic conjunctivitis indication 473460002 DOID:11204
Eustachian Tube Congestion indication
Brain damage contraindication 2470005
Ocular hypertension contraindication 4210003 DOID:9282
Tachyarrhythmia contraindication 6285003
Suicidal thoughts contraindication 6471006
Dependent drug abuse contraindication 6525002
Urinary tract obstruction contraindication 7163005 DOID:5200
Alcoholism contraindication 7200002
Alcohol withdrawal delirium contraindication 8635005
Peptic ulcer contraindication 13200003 DOID:750
Chronic obstructive lung disease contraindication 13645005 DOID:3083
Asthenia contraindication 13791008
Hyperkalemia contraindication 14140009
Severe chronic ulcerative colitis contraindication 14311001
Constipation contraindication 14760008 DOID:2089
Disorder of autonomic nervous system contraindication 15241006
Chronic disease of respiratory system contraindication 17097001
Mood swings contraindication 18963009
Pulmonary edema contraindication 19242006 DOID:11396
Myocardial infarction contraindication 22298006 DOID:5844
Glaucoma contraindication 23986001 DOID:1686
Inflammatory bowel disease contraindication 24526004 DOID:0050589
Ventricular tachycardia contraindication 25569003
Alcohol intoxication contraindication 25702006
Shock contraindication 27942005
Toxic megacolon contraindication 28536002 DOID:1770
Atony of colon contraindication 29479008
Hypercapnia contraindication 29596007
Dehydration contraindication 34095006
Hyperthyroidism contraindication 34486009 DOID:7998
Acute hepatitis contraindication 37871000
Hypertensive disorder contraindication 38341003 DOID:10763
Hypovolemic shock contraindication 39419009
Disorder of gallbladder contraindication 39621005 DOID:0060262
Gastrointestinal ulcer contraindication 40845000
Hypothyroidism contraindication 40930008 DOID:1459
Complete trisomy 21 syndrome contraindication 41040004 DOID:14250
Third trimester pregnancy contraindication 41587001
Body fluid retention contraindication 43498006
Conduction disorder of the heart contraindication 44808001
Low blood pressure contraindication 45007003
Achalasia of esophagus contraindication 45564002 DOID:9164
Chronic heart failure contraindication 48447003
Bradycardia contraindication 48867003
Disorder of cardiovascular system contraindication 49601007 DOID:1287
Acidosis contraindication 51387008
Gastrointestinal perforation contraindication 51875005
Coronary arteriosclerosis contraindication 53741008 DOID:3393
Paralytic ileus contraindication 55525008 DOID:8442
Peptic reflux disease contraindication 57643001
Multiple organ failure contraindication 57653000
Acute nephropathy contraindication 58574008
Metabolic acidosis contraindication 59455009
Hepatic failure contraindication 59927004
Ulcerative colitis contraindication 64766004 DOID:8577
Blood coagulation disorder contraindication 64779008 DOID:1247
Arterial thrombosis contraindication 65198009
Drug AND/OR toxin-induced diarrhea contraindication 65979008
Substance abuse contraindication 66214007
Benign intracranial hypertension contraindication 68267002 DOID:11459
Poisoning by acetaminophen contraindication 70273001
Arteriosclerotic vascular disease contraindication 72092001
Diabetes mellitus contraindication 73211009 DOID:9351
Gastrointestinal hemorrhage contraindication 74474003
Urethral stricture contraindication 76618002
Spastic paralysis contraindication 78403003
Disturbance of salivary secretion contraindication 78948009
Decreased respiratory function contraindication 80954004
Injury of head contraindication 82271004
Chronic idiopathic constipation contraindication 82934008
Cor pulmonale contraindication 83291003 DOID:8515
Hiatal hernia contraindication 84089009 DOID:12642
Epilepsy contraindication 84757009 DOID:1826
Pulmonary emphysema contraindication 87433001
Kidney disease contraindication 90708001 DOID:557
Myasthenia gravis contraindication 91637004 DOID:437
Acute abdominal pain contraindication 116290004
Procedure on urinary system contraindication 118677009
Gastrointestinal obstruction contraindication 126765001
Neoplasm of brain contraindication 126952004 DOID:1319
Seizure disorder contraindication 128613002
Autonomic dysreflexia contraindication 129618003
Bleeding contraindication 131148009
Liver function tests abnormal contraindication 166603001
Cystic fibrosis contraindication 190905008 DOID:1485
Drug-induced psychosis contraindication 191483003 DOID:1742
Angina pectoris contraindication 194828000
Partial atrioventricular block contraindication 195039008
Acute pancreatitis contraindication 197456007 DOID:2913
Impaired renal function disorder contraindication 197663003
Cerebrovascular accident contraindication 230690007
Coronary artery bypass graft contraindication 232717009
Myocardial dysfunction contraindication 233928007
Gastroesophageal reflux disease contraindication 235595009 DOID:8534
Disease of liver contraindication 235856003 DOID:409
Hyporeninemic hypoaldosteronism contraindication 236464008
Bladder outflow obstruction contraindication 236645006
Morbid obesity contraindication 238136002 DOID:11981
Sepsis syndrome contraindication 238150007
Rhabdomyolysis contraindication 240131006
Pyloric obstruction contraindication 244815007
Esophageal dysmotility contraindication 266434009 DOID:9192
Benign prostatic hyperplasia contraindication 266569009
Edema contraindication 267038008
Retention of urine contraindication 267064002
Anemia contraindication 271737000 DOID:2355
Continuous fever contraindication 271751000
Drowsy contraindication 271782001
Exacerbation of asthma contraindication 281239006
Pregnancy, function contraindication 289908002
Lesion of brain contraindication 301766008
Thromboembolic disorder contraindication 371039008
Coma contraindication 371632003
Primary adrenocortical insufficiency contraindication 373662000
Smoking cessation assistance contraindication 384742004
Operation on gastrointestinal tract contraindication 386621005
Hypoxia contraindication 389086002
Angle-closure glaucoma contraindication 392291006 DOID:13550
Cardiovascular event risk contraindication 395112001
Pseudomembranous enterocolitis contraindication 397683000
Gastric ulcer contraindication 397825006 DOID:10808
Breastfeeding (mother) contraindication 413712001
Chronic lung disease contraindication 413839001
Disorder of coronary artery contraindication 414024009
Traumatic injury contraindication 417746004
Central nervous system depression contraindication 418072004
Ultrarapid metabolizer due to cytochrome p450 CYP2D6 variant contraindication 422681000
Fever greater than 100.4 Fahrenheit contraindication 426000000
Dysfunction of sphincter of Oddi contraindication 430887001
Hypertensive urgency contraindication 443482000
Smokes tobacco daily contraindication 449868002
Acute exacerbation of asthma contraindication 708038006
Acute Thromboembolic Stroke contraindication
Theophylline Toxicity contraindication
Severe Hypoxemia contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.22 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
5MG;120MG ZYRTEC-D 12 HOUR J AND J CONSUMER INC N021150 Nov. 9, 2007 OTC TABLET, EXTENDED RELEASE ORAL 7226614 June 10, 2022 TREATMENT OF SEASONAL AND PERENNIAL ALLERGIC RHINITIS SYMPTOMS

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Sodium-dependent noradrenaline transporter Transporter RELEASING AGENT CHEMBL CHEMBL
Beta-2 adrenergic receptor GPCR WOMBAT-PK
Alpha-2A adrenergic receptor GPCR WOMBAT-PK
Alpha-1A adrenergic receptor GPCR WOMBAT-PK

External reference:

IDSource
4018571 VUID
N0000178581 NUI
D00485 KEGG_DRUG
345-78-8 SECONDARY_CAS_RN
7460-12-0 SECONDARY_CAS_RN
4018043 VANDF
4018571 VANDF
4018802 VANDF
C0033798 UMLSCUI
CHEBI:51209 CHEBI
CHEMBL1590 ChEMBL_ID
DB00852 DRUGBANK_ID
CHEMBL1200724 ChEMBL_ID
CHEMBL3989855 ChEMBL_ID
D054199 MESH_DESCRIPTOR_UI
7028 PUBCHEM_CID
1061 INN_ID
7286 IUPHAR_LIGAND_ID
7CUC9DDI9F UNII
407885 RXNORM
2354 MMSL
5382 MMSL
5383 MMSL
5384 MMSL
d00769 MMSL
001831 NDDF
001832 NDDF
001833 NDDF
005972 NDDF
10595003 SNOMEDCT_US
12177002 SNOMEDCT_US
372900003 SNOMEDCT_US
91435002 SNOMEDCT_US
CHEMBL1201483 ChEMBL_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Dimetapp HUMAN OTC DRUG LABEL 2 0031-2231 ELIXIR 15 mg ORAL Export only 15 sections
Dimetapp Paediatric HUMAN OTC DRUG LABEL 2 0031-2251 ELIXIR 15 mg ORAL Export only 1 sections
Robitussin CF HUMAN OTC DRUG LABEL 3 0031-8678 LIQUID 30 mg ORAL Export only 15 sections
Good Sense Suphedrine12 Hour HUMAN OTC DRUG LABEL 1 0113-0054 TABLET, FILM COATED, EXTENDED RELEASE 120 mg ORAL ANDA 14 sections
good sense all day allergy d HUMAN OTC DRUG LABEL 2 0113-0147 TABLET, FILM COATED, EXTENDED RELEASE 120 mg ORAL ANDA 16 sections
Good Sense All Day Allergy D HUMAN OTC DRUG LABEL 2 0113-0176 TABLET, EXTENDED RELEASE 120 mg ORAL ANDA 16 sections
Zephrex D HUMAN OTC DRUG LABEL 1 0113-0401 CAPSULE, GELATIN COATED 30 mg ORAL OTC monograph final 14 sections
Good Sense Nasal Decongestant HUMAN OTC DRUG LABEL 1 0113-0432 TABLET, FILM COATED 30 mg ORAL OTC monograph final 15 sections
Mucus D HUMAN OTC DRUG LABEL 2 0113-2002 TABLET 60 mg ORAL ANDA 14 sections
Allergy and Congestion Relief HUMAN OTC DRUG LABEL 2 0113-2007 TABLET, FILM COATED, EXTENDED RELEASE 120 mg ORAL ANDA 14 sections
sinus congestion HUMAN OTC DRUG LABEL 1 0113-2008 TABLET, FILM COATED 30 mg ORAL OTC monograph final 15 sections
sinus 12 hour HUMAN OTC DRUG LABEL 1 0113-2017 TABLET, FILM COATED, EXTENDED RELEASE 120 mg ORAL ANDA 14 sections
All Day Allergy-D HUMAN OTC DRUG LABEL 2 0113-2176 TABLET, EXTENDED RELEASE 120 mg ORAL ANDA 16 sections
perrigo allergy d HUMAN OTC DRUG LABEL 2 0113-7777 TABLET, FILM COATED, EXTENDED RELEASE 120 mg ORAL ANDA 15 sections
Brompheniramine Maleate, Pseudoephedrine Hydrochloride and Dextromethorphan Hydrobromide HUMAN PRESCRIPTION DRUG LABEL 3 0121-0933 SOLUTION 30 mg ORAL ANDA 21 sections
Aleve-D Sinus and Headache HUMAN OTC DRUG LABEL 2 0280-6045 TABLET 120 mg ORAL ANDA 17 sections
Aleve-D Sinus and Cold HUMAN OTC DRUG LABEL 2 0280-6090 TABLET 120 mg ORAL ANDA 17 sections
walphed dmaximum strength non drowsy sinus HUMAN OTC DRUG LABEL 1 0363-0061 TABLET, FILM COATED, EXTENDED RELEASE 120 mg ORAL ANDA 14 sections
Guaifenesin and Pseudoephedrine Hydrochloride HUMAN OTC DRUG LABEL 2 0363-0077 TABLET, EXTENDED RELEASE 60 mg ORAL NDA 16 sections
Fexofenadine Hydrochloride and Pseudoephedrine Hydrochloride Human OTC Drug Label 2 0363-0094 TABLET, FILM COATED, EXTENDED RELEASE 120 mg ORAL ANDA 11 sections
Wal-phed HUMAN OTC DRUG LABEL 2 0363-0111 TABLET 60 mg ORAL OTC monograph final 16 sections
Wal-phed HUMAN OTC DRUG LABEL 2 0363-0111 TABLET 60 mg ORAL OTC monograph final 16 sections
Wal-phed HUMAN OTC DRUG LABEL 1 0363-0112 TABLET, FILM COATED 30 mg ORAL OTC monograph final 15 sections
Guaifenesin and Pseudoephedrine HCl Human OTC Drug Label 2 0363-0134 TABLET, EXTENDED RELEASE 120 mg ORAL ANDA 14 sections
Guaifenesin and Pseudoephedrine HCl Human OTC Drug Label 2 0363-0134 TABLET, EXTENDED RELEASE 120 mg ORAL ANDA 14 sections
Mucus Relief D HUMAN OTC DRUG LABEL 2 0363-0144 TABLET, EXTENDED RELEASE 60 mg ORAL ANDA 14 sections
Wal-Act HUMAN OTC DRUG LABEL 2 0363-0178 TABLET, FILM COATED 60 mg ORAL OTC monograph final 16 sections
Pseudoephedrine Hydrochloride HUMAN OTC DRUG LABEL 1 0363-0204 TABLET, FILM COATED, EXTENDED RELEASE 120 mg ORAL ANDA 16 sections
Pseudoephedrine Hydrochloride HUMAN OTC DRUG LABEL 1 0363-0204 TABLET, FILM COATED, EXTENDED RELEASE 120 mg ORAL ANDA 16 sections
Wal-Finate D HUMAN OTC DRUG LABEL 2 0363-0382 TABLET 60 mg ORAL OTC MONOGRAPH FINAL 16 sections