pseudoephedrine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
sympathomimetics 2326 90-82-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • pseudoephedrine
  • (+)-Pseudoephedrine
  • pseudophedrine sulphate
  • pseudoephedrine hydrochloride
  • pseudoephedrine sulfate
  • pseudoephedrine HCl
  • pseudoephedrine polistirex
A phenethylamine that is an isomer of EPHEDRINE which has less central nervous system effects and usage is mainly for respiratory tract decongestion.
  • Molecular weight: 165.24
  • Formula: C10H15NO
  • CLOGP: 0.89
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 2
  • TPSA: 32.26
  • ALOGS: -1.30
  • ROTB: 3
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.24 g O
0.24 g O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 43 % Benet LZ, Broccatelli F, Oprea TI

Approvals:

DateAgencyCompanyOrphan
Oct. 18, 1963 FDA SCHERING PLOUGH

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pemphigus 3390.40 26.82 2995 138907 180731 63166389
Systemic lupus erythematosus 3130.51 26.82 3032 138870 205886 63141234
Glossodynia 2980.29 26.82 2754 139148 176122 63170998
Hand deformity 2927.04 26.82 2593 139309 156864 63190256
Wound 2850.55 26.82 2581 139321 160682 63186438
Pericarditis 2838.89 26.82 2348 139554 129231 63217889
Anti-cyclic citrullinated peptide antibody positive 2466.62 26.82 2055 139847 114157 63232963
Discomfort 2427.15 26.82 2388 139514 164986 63182134
Abdominal discomfort 2173.74 26.82 3099 138803 317786 63029334
Arthropathy 2128.37 26.82 2617 139285 232175 63114945
Synovitis 2091.44 26.82 2322 139580 184596 63162524
Alopecia 2042.13 26.82 3091 138811 334445 63012675
Swelling 1906.74 26.82 2689 139213 272689 63074431
Duodenal ulcer perforation 1842.37 26.82 1539 140363 85670 63261450
Helicobacter infection 1739.22 26.82 1529 140373 91256 63255864
Hepatic enzyme increased 1692.79 26.82 2168 139734 200160 63146960
Contraindicated product administered 1629.01 26.82 2208 139694 215440 63131680
Maternal exposure during pregnancy 1527.42 26.82 2153 139749 217909 63129211
Infusion related reaction 1521.01 26.82 2276 139626 243245 63103875
Rheumatoid factor positive 1381.03 26.82 1289 140613 83117 63264003
Hypersensitivity 1335.10 26.82 2362 139540 290323 63056797
Drug intolerance 1195.49 26.82 2322 139580 306339 63040781
Product use issue 1151.46 26.82 1891 140011 218629 63128491
Blister 1004.31 26.82 1340 140562 128474 63218646
Joint swelling 994.54 26.82 2231 139671 325435 63021685
Therapeutic product effect decreased 976.19 26.82 1633 140269 191554 63155566
Rheumatic fever 944.99 26.82 778 141124 42333 63304787
Folliculitis 913.20 26.82 947 140955 69370 63277750
Muscle injury 881.01 26.82 898 141004 64447 63282673
Irritable bowel syndrome 852.95 26.82 985 140917 81427 63265693
Treatment failure 837.71 26.82 1553 140349 197490 63149630
Swollen joint count increased 828.74 26.82 669 141233 35385 63311735
Sleep disorder due to general medical condition, insomnia type 776.51 26.82 757 141145 51460 63295660
Type 2 diabetes mellitus 660.03 26.82 763 141139 63105 63284015
Blood cholesterol increased 634.07 26.82 909 140993 93123 63253997
Impaired healing 599.31 26.82 927 140975 101615 63245505
Pain 598.83 26.82 3238 138664 737390 62609730
Fall 598.09 26.82 84 141818 392250 62954870
Death 575.72 26.82 78 141824 374303 62972817
Rash 539.87 26.82 2577 139325 558294 62788826
Anaemia 531.61 26.82 31 141871 293399 63053721
Rheumatoid arthritis 520.10 26.82 1491 140411 252328 63094792
Acute kidney injury 485.89 26.82 25 141877 263390 63083730
Liver injury 484.65 26.82 636 141266 59884 63287236
Hip arthroplasty 468.45 26.82 555 141347 47091 63300029
Hypotension 464.24 26.82 39 141863 272565 63074555
Nausea 437.70 26.82 778 141124 853693 62493427
Stomatitis 433.12 26.82 957 140945 137768 63209352
General physical health deterioration 415.02 26.82 1186 140716 200216 63146904
Lower respiratory tract infection 405.43 26.82 906 140996 131401 63215719
Diarrhoea 400.70 26.82 614 141288 714752 62632368
Musculoskeletal stiffness 397.80 26.82 1105 140797 183513 63163607
Cough 394.93 26.82 86 141816 292657 63054463
Urinary tract infection 379.62 26.82 67 141835 264617 63082503
Drug interaction 373.49 26.82 39 141863 229092 63118028
Knee arthroplasty 363.62 26.82 523 141379 53683 63293437
Ill-defined disorder 353.26 26.82 646 141256 81109 63266011
Gastrointestinal disorder 349.85 26.82 851 141051 130388 63216732
Psoriatic arthropathy 343.42 26.82 681 141221 90839 63256281
Product dose omission issue 325.92 26.82 64 141838 234249 63112871
Back pain 315.46 26.82 99 141803 264046 63083074
Neutropenia 309.22 26.82 21 141881 174984 63172136
Intentional product use issue 300.86 26.82 791 141111 127101 63220019
Injury 296.68 26.82 563 141339 72684 63274436
Constipation 283.81 26.82 76 141826 224867 63122253
Toxicity to various agents 282.39 26.82 100 141802 247150 63099970
Sepsis 262.99 26.82 21 141881 153102 63194018
Somnolence 258.77 26.82 44 141858 178641 63168479
Thrombocytopenia 250.72 26.82 24 141878 151133 63195987
Haemoglobin decreased 249.73 26.82 20 141882 145465 63201655
Dehydration 248.16 26.82 44 141858 173310 63173810
Erythema 234.06 26.82 53 141849 175698 63171422
Pneumonia 225.59 26.82 424 141478 456343 62890777
Febrile neutropenia 222.21 26.82 10 141892 118439 63228681
Disease progression 221.97 26.82 13 141889 122745 63224375
Adverse event 220.74 26.82 475 141427 67084 63280036
Asthenia 219.09 26.82 324 141578 383280 62963840
Infection 216.21 26.82 1049 140853 228124 63118996
Live birth 209.16 26.82 272 141630 25358 63321762
Hyponatraemia 204.94 26.82 11 141891 111889 63235231
Prescribed overdose 203.79 26.82 312 141590 33841 63313279
Fibromyalgia 202.00 26.82 510 141392 79910 63267210
Atrial fibrillation 200.25 26.82 16 141886 116620 63230500
Renal failure 199.61 26.82 17 141885 117635 63229485
Injection site pain 199.25 26.82 27 141875 129773 63217347
Blood pressure increased 198.30 26.82 58 141844 162004 63185116
Pancytopenia 196.84 26.82 4 141898 96929 63250191
Contusion 194.49 26.82 756 141146 149288 63197832
Myalgia 193.47 26.82 45 141857 146484 63200636
White blood cell count decreased 185.09 26.82 42 141860 139062 63208058
Weight decreased 183.44 26.82 209 141693 276589 63070531
Platelet count decreased 176.23 26.82 25 141877 116097 63231023
Tremor 175.79 26.82 40 141862 132199 63214921
Cardiac failure 172.35 26.82 6 141896 89136 63257984
Fatigue 171.57 26.82 2858 139044 885170 62461950
Renal impairment 170.65 26.82 6 141896 88349 63258771
Hypokalaemia 165.62 26.82 19 141883 103785 63243335
Oxygen saturation decreased 164.45 26.82 8 141894 88577 63258543
Malignant neoplasm progression 164.36 26.82 4 141898 82117 63265003
Seizure 163.10 26.82 47 141855 132587 63214533
Syncope 161.13 26.82 33 141869 117352 63229768
Mobility decreased 159.85 26.82 614 141288 120545 63226575
COVID-19 159.03 26.82 30 141872 113073 63234047
Drug ineffective 157.53 26.82 3235 138667 1041530 62305590
Confusional state 155.78 26.82 982 140920 235398 63111722
Blood creatinine increased 153.76 26.82 11 141891 87833 63259287
Vomiting 152.66 26.82 688 141214 558929 62788191
Respiratory failure 152.08 26.82 23 141879 101835 63245285
Gastrointestinal haemorrhage 151.76 26.82 7 141895 81169 63265951
Oropharyngeal pain 151.49 26.82 17 141885 94470 63252650
Completed suicide 151.33 26.82 68 141834 145605 63201515
Cerebrovascular accident 151.14 26.82 29 141873 107995 63239125
Deep vein thrombosis postoperative 150.75 26.82 155 141747 11214 63335906
Drug tolerance decreased 149.73 26.82 190 141712 17283 63329837
Myocardial infarction 148.13 26.82 23 141879 99870 63247250
Leukopenia 146.69 26.82 6 141896 77284 63269836
Neuropathy peripheral 145.93 26.82 37 141865 113630 63233490
Sinusitis 144.64 26.82 934 140968 225719 63121401
Abdominal pain 143.24 26.82 274 141628 293182 63053938
Herpes zoster 142.41 26.82 11 141891 82451 63264669
Influenza 142.29 26.82 34 141868 108688 63238432
Lip dry 141.81 26.82 174 141728 15296 63331824
Loss of consciousness 141.34 26.82 44 141858 118077 63229043
Inappropriate schedule of product administration 141.10 26.82 30 141872 103935 63243185
Alanine aminotransferase increased 140.72 26.82 30 141872 103740 63243380
Adjustment disorder with depressed mood 140.54 26.82 142 141760 10062 63337058
Pleural effusion 139.27 26.82 21 141881 93189 63253931
Facet joint syndrome 138.85 26.82 153 141749 11985 63335135
Balance disorder 138.38 26.82 14 141888 84408 63262712
Chills 137.89 26.82 41 141861 113337 63233783
Chest discomfort 137.00 26.82 38 141864 109931 63237189
Feeling abnormal 136.70 26.82 81 141821 148311 63198809
Cardiac failure congestive 133.22 26.82 23 141879 92410 63254710
Bradycardia 131.61 26.82 8 141894 73219 63273901
Hyperhidrosis 131.13 26.82 39 141863 107797 63239323
Blood glucose increased 129.52 26.82 17 141885 83739 63263381
Malaise 126.55 26.82 490 141412 415464 62931656
Nasopharyngitis 126.23 26.82 986 140916 253271 63093849
Dislocation of vertebra 126.00 26.82 124 141778 8511 63338609
Aspartate aminotransferase increased 124.68 26.82 25 141877 90252 63256868
Anti-cyclic citrullinated peptide antibody 121.56 26.82 109 141793 6649 63340471
Adverse drug reaction 121.13 26.82 423 141479 79291 63267829
Prescribed underdose 121.11 26.82 229 141673 29460 63317660
Exposure during pregnancy 120.23 26.82 674 141228 154873 63192247
Injection site erythema 119.20 26.82 21 141881 83153 63263967
Septic shock 117.60 26.82 8 141894 66621 63280499
Hypoglycaemia 116.26 26.82 4 141898 60061 63287059
Pulmonary embolism 115.75 26.82 58 141844 116626 63230494
Heart rate increased 114.73 26.82 34 141868 94204 63252916
Tachycardia 113.84 26.82 61 141841 118095 63229025
Dizziness 113.84 26.82 534 141368 429391 62917729
Multiple organ dysfunction syndrome 112.67 26.82 3 141899 56749 63290371
Cellulitis 112.55 26.82 23 141879 81935 63265185
Palpitations 111.95 26.82 56 141846 112714 63234406
Peripheral venous disease 110.62 26.82 154 141748 15323 63331797
Vision blurred 108.61 26.82 35 141867 91889 63255231
Autoimmune disorder 108.25 26.82 161 141741 17016 63330104
Grip strength decreased 107.61 26.82 185 141717 22102 63325018
Dyspnoea exertional 107.13 26.82 7 141895 60295 63286825
Hyperkalaemia 107.10 26.82 3 141899 54200 63292920
Cardiac arrest 106.27 26.82 37 141865 92508 63254612
Overdose 105.72 26.82 63 141839 115015 63232105
Retinitis 105.69 26.82 97 141805 6099 63341021
Intentional overdose 105.66 26.82 19 141883 74133 63272987
Blood pressure decreased 103.46 26.82 12 141890 65010 63282110
Depressed level of consciousness 102.51 26.82 10 141892 62068 63285052
Influenza like illness 102.28 26.82 14 141888 66810 63280310
Wrong technique in product usage process 100.46 26.82 11 141891 62329 63284791
Productive cough 99.74 26.82 12 141890 63196 63283924
Condition aggravated 99.43 26.82 1352 140550 400865 62946255
Flushing 99.19 26.82 23 141879 75064 63272056
Epistaxis 98.64 26.82 21 141881 72704 63274416
X-ray abnormal 97.60 26.82 105 141797 8005 63339115
Electrocardiogram QT prolonged 97.23 26.82 10 141892 59520 63287600
Bronchitis 96.90 26.82 82 141820 124853 63222267
Psoriasis 96.07 26.82 37 141865 86920 63260200
Blood pressure systolic increased 92.28 26.82 3 141899 47394 63299726
Mucosal inflammation 91.26 26.82 3 141899 46925 63300195
Dysphagia 90.96 26.82 42 141860 88543 63258577
Vertigo 90.59 26.82 13 141889 59874 63287246
Haemorrhage 90.57 26.82 14 141888 61008 63286112
Arthralgia 90.16 26.82 1779 140123 567931 62779189
Neutrophil count decreased 88.29 26.82 11 141891 56395 63290725
Hypoxia 88.10 26.82 14 141888 59778 63287342
Pain in extremity 88.09 26.82 411 141491 331075 63016045
Breast cancer 87.81 26.82 5 141897 48378 63298742
Chronic obstructive pulmonary disease 87.30 26.82 17 141885 62669 63284451
Weight increased 86.40 26.82 927 140975 259865 63087255
Incorrect dose administered 86.23 26.82 15 141887 59953 63287167
Anxiety 85.03 26.82 229 141673 217312 63129808
Rash pruritic 83.74 26.82 16 141886 59783 63287337
Thrombosis 83.25 26.82 21 141881 64734 63282386
Heart rate decreased 81.79 26.82 5 141897 45555 63301565
Suicide attempt 81.78 26.82 18 141884 60900 63286220
Joint range of motion decreased 81.73 26.82 206 141696 32222 63314898
Cystitis 80.75 26.82 13 141889 54978 63292142
Lethargy 80.55 26.82 14 141888 55993 63291127
Bone pain 80.05 26.82 13 141889 54628 63292492
Cardio-respiratory arrest 79.92 26.82 18 141884 59941 63287179
Drug abuse 79.87 26.82 31 141871 72487 63274633
Cardiac disorder 79.32 26.82 10 141892 50806 63296314
Rhabdomyolysis 78.37 26.82 5 141897 43946 63303174
Metabolic acidosis 77.84 26.82 6 141896 45063 63302057
Injection site swelling 77.66 26.82 8 141894 47564 63299556
Abdominal distension 77.34 26.82 49 141853 86566 63260554
Peripheral swelling 77.09 26.82 921 140981 265021 63082099
Coma 76.93 26.82 24 141878 64340 63282780
Abortion spontaneous 76.88 26.82 8 141894 47187 63299933
Angioedema 75.94 26.82 9 141893 47956 63299164
Dyspnoea 75.68 26.82 1033 140869 660280 62686840
Suicidal ideation 75.10 26.82 23 141879 62398 63284722
Multiple sclerosis relapse 74.56 26.82 10 141892 48468 63298652
Cataract 74.32 26.82 18 141884 57035 63290085
Agitation 73.76 26.82 21 141881 59736 63287384
Burning sensation 73.19 26.82 16 141886 54391 63292729
Blood pressure fluctuation 72.57 26.82 9 141893 46308 63300812
Breast cancer stage III 72.22 26.82 102 141800 10284 63336836
Pulmonary oedema 72.09 26.82 17 141885 54856 63292264
Cognitive disorder 71.94 26.82 18 141884 55797 63291323
Stress 71.87 26.82 30 141872 67137 63279983
Liver function test abnormal 71.63 26.82 11 141891 48170 63298950
Ascites 71.55 26.82 5 141897 40723 63306397
Haematochezia 71.52 26.82 16 141886 53528 63293592
Deep vein thrombosis 70.02 26.82 51 141851 83749 63263371
Depression 69.36 26.82 217 141685 196275 63150845
Lactic acidosis 69.35 26.82 4 141898 38283 63308837
Interstitial lung disease 68.95 26.82 26 141876 61882 63285238
Disorientation 68.85 26.82 5 141897 39447 63307673
Speech disorder 68.53 26.82 6 141896 40623 63306497
Hyperglycaemia 68.45 26.82 7 141895 41860 63305260
Femur fracture 68.22 26.82 7 141895 41749 63305371
Dysarthria 67.65 26.82 8 141894 42703 63304417
Lupus vulgaris 67.60 26.82 75 141827 5919 63341201
Sedation 67.50 26.82 5 141897 38804 63308316
Rhinorrhoea 67.46 26.82 31 141871 65546 63281574
Rash erythematous 67.24 26.82 8 141894 42502 63304618
Hepatic function abnormal 66.91 26.82 4 141898 37138 63309982
Pulmonary fibrosis 66.39 26.82 218 141684 39591 63307529
Red blood cell count decreased 65.93 26.82 7 141895 40638 63306482
Injection site pruritus 65.49 26.82 11 141891 45105 63302015
Wound infection 64.75 26.82 146 141756 21264 63325856
Plasma cell myeloma 64.28 26.82 4 141898 35901 63311219
Pulmonary hypertension 63.95 26.82 5 141897 37118 63310002
Skin ulcer 63.60 26.82 10 141892 43035 63304085
Unevaluable event 63.53 26.82 18 141884 51368 63295752
Skin discolouration 62.70 26.82 6 141896 37822 63309298
Throat irritation 62.32 26.82 6 141896 37641 63309479
Encephalopathy 61.76 26.82 7 141895 38613 63308507
International normalised ratio increased 61.75 26.82 14 141888 46411 63300709
Nasal congestion 61.63 26.82 35 141867 65625 63281495
Acute respiratory failure 61.26 26.82 4 141898 34481 63312639
Illness 60.99 26.82 17 141885 49042 63298078
Pancreatitis 60.98 26.82 17 141885 49038 63298082
Pain in jaw 60.14 26.82 12 141890 43484 63303636
Osteonecrosis of jaw 59.75 26.82 5 141897 35118 63312002
Skin exfoliation 59.37 26.82 12 141890 43090 63304030
Blood potassium decreased 59.36 26.82 11 141891 42015 63305105
Injection site bruising 59.14 26.82 11 141891 41899 63305221
Blood alkaline phosphatase increased 59.10 26.82 12 141890 42955 63304165
Hypothyroidism 58.45 26.82 12 141890 42620 63304500
Hypocalcaemia 58.41 26.82 3 141899 31710 63315410
Dysphonia 58.27 26.82 17 141885 47597 63299523
Hepatic failure 58.19 26.82 6 141896 35650 63311470
Colitis 58.16 26.82 18 141884 48510 63298610
Pregnancy 58.13 26.82 198 141704 36638 63310482
Mouth ulceration 58.08 26.82 4 141898 32980 63314140
Respiratory distress 57.30 26.82 5 141897 33946 63313174
Device expulsion 56.68 26.82 6 141896 34916 63312204
C-reactive protein 56.63 26.82 62 141840 4820 63342300
Swelling face 56.54 26.82 36 141866 63439 63283681
Hallucination 56.25 26.82 26 141876 54791 63292329
Surgery 56.21 26.82 7 141895 35905 63311215
No adverse event 56.05 26.82 12 141890 41393 63305727
Maternal exposure timing unspecified 55.93 26.82 74 141828 7013 63340107
Fluid retention 55.75 26.82 32 141870 59654 63287466
Haematemesis 55.63 26.82 3 141899 30409 63316711
Hospitalisation 55.44 26.82 65 141837 85016 63262104
Transient ischaemic attack 55.26 26.82 9 141893 37744 63309376
Localised infection 55.19 26.82 3 141899 30207 63316913
Dysgeusia 54.79 26.82 18 141884 46692 63300428
Insomnia 54.72 26.82 271 141631 214981 63132139
Diverticulitis 54.51 26.82 11 141891 39546 63307574
Hot flush 54.49 26.82 23 141879 51136 63295984
Lymphadenopathy 54.46 26.82 10 141892 38448 63308672
Orthostatic hypotension 54.34 26.82 8 141894 36152 63310968
Chronic kidney disease 54.12 26.82 17 141885 45381 63301739
Haematoma 53.98 26.82 7 141895 34813 63312307
Fungal infection 53.50 26.82 9 141893 36865 63310255
Acute myocardial infarction 53.49 26.82 5 141897 32119 63315001
Dyskinesia 53.24 26.82 5 141897 31997 63315123
Upper respiratory tract infection 53.12 26.82 63 141839 81984 63265136
Anaphylactic reaction 52.95 26.82 42 141860 66058 63281062
Therapy cessation 52.75 26.82 4 141898 30453 63316667
Mental status changes 52.55 26.82 12 141890 39587 63307533
Pneumonitis 52.45 26.82 8 141894 35214 63311906
Dry skin 52.43 26.82 31 141871 56856 63290264
Rectal haemorrhage 52.29 26.82 22 141880 49008 63298112
Drug reaction with eosinophilia and systemic symptoms 51.98 26.82 7 141895 33829 63313291
Transaminases increased 51.92 26.82 5 141897 31362 63315758
Pericardial effusion 51.91 26.82 4 141898 30054 63317066
Depressed mood 51.72 26.82 13 141889 40178 63306942
Hypercalcaemia 51.17 26.82 3 141899 28319 63318801
Pneumonia aspiration 51.08 26.82 8 141894 34532 63312588
Oedema peripheral 50.84 26.82 234 141668 189277 63157843
Seronegative arthritis 50.73 26.82 53 141849 3906 63343214
Foetal exposure during pregnancy 50.59 26.82 6 141896 31956 63315164
Walking aid user 50.48 26.82 88 141814 10629 63336491
Rash maculo-papular 50.46 26.82 6 141896 31890 63315230
Renal disorder 50.24 26.82 7 141895 32967 63314153
Gastritis 50.11 26.82 11 141891 37292 63309828
Haematocrit decreased 50.10 26.82 13 141889 39327 63307793
Staphylococcal infection 49.99 26.82 15 141887 41241 63305879
Urinary retention 49.71 26.82 5 141897 30296 63316824
Hepatocellular injury 49.16 26.82 3 141899 27378 63319742
Drug eruption 49.05 26.82 4 141898 28690 63318430
Cerebral haemorrhage 48.07 26.82 6 141896 30723 63316397
Onychomadesis 47.67 26.82 62 141840 5778 63341342
Hepatotoxicity 47.63 26.82 12 141890 37029 63310091
Basal cell carcinoma 47.57 26.82 4 141898 27987 63319133
Jaundice 47.54 26.82 5 141897 29246 63317874
Eye pain 47.52 26.82 9 141893 33845 63313275
Gastroenteritis 47.48 26.82 3 141899 26587 63320533
Blood creatine phosphokinase increased 47.46 26.82 6 141896 30424 63316696
Swollen tongue 47.28 26.82 10 141892 34790 63312330
Intentional product misuse 47.19 26.82 40 141862 60877 63286243
Lymphocyte count decreased 47.11 26.82 6 141896 30251 63316869
Tinnitus 46.87 26.82 11 141891 35617 63311503
Hypophagia 46.78 26.82 7 141895 31252 63315868
Haemoptysis 46.45 26.82 5 141897 28721 63318399
Lip swelling 46.38 26.82 7 141895 31056 63316064
Accidental exposure to product 46.35 26.82 4 141898 27401 63319719
Headache 45.91 26.82 1072 140830 632169 62714951
Skin lesion 45.69 26.82 7 141895 30714 63316406
Feeling hot 45.62 26.82 28 141874 50326 63296794
Lower limb fracture 45.30 26.82 138 141764 24083 63323037
Limb injury 45.12 26.82 3 141899 25474 63321646
Haematuria 44.87 26.82 6 141896 29151 63317969
Presyncope 44.52 26.82 5 141897 27780 63319340
Exostosis 44.51 26.82 113 141789 17749 63329371
Blood urea increased 44.21 26.82 4 141898 26375 63320745
Dry eye 43.93 26.82 18 141884 40743 63306377
Head injury 43.72 26.82 5 141897 27391 63319729
Respiratory tract infection 43.62 26.82 19 141883 41464 63305656
Hip fracture 43.20 26.82 7 141895 29467 63317653
Nephrolithiasis 42.94 26.82 20 141882 41964 63305156
Oedema 42.63 26.82 368 141534 97254 63249866
Blood sodium decreased 42.53 26.82 3 141899 24249 63322871
Arrhythmia 42.50 26.82 16 141886 38124 63308996
Body temperature increased 42.46 26.82 15 141887 37177 63309943
Hypercholesterolaemia 42.21 26.82 124 141778 21210 63325910
Bone erosion 42.00 26.82 110 141792 17607 63329513
Lupus-like syndrome 41.54 26.82 100 141802 15195 63331925
Limb discomfort 41.50 26.82 8 141894 29708 63317412
Viral infection 41.37 26.82 14 141888 35649 63311471
Dysuria 41.37 26.82 12 141890 33726 63313394
Obesity 41.27 26.82 154 141748 29798 63317322
Stevens-Johnson syndrome 41.24 26.82 4 141898 24946 63322174
Pallor 41.09 26.82 9 141893 30559 63316561
Restlessness 40.98 26.82 8 141894 29445 63317675
Gastrooesophageal reflux disease 40.96 26.82 96 141806 95543 63251577
Candida infection 40.96 26.82 7 141895 28344 63318776
Kidney infection 40.26 26.82 3 141899 23173 63323947
Angina pectoris 40.14 26.82 9 141893 30069 63317051
Palmar-plantar erythrodysaesthesia syndrome 39.92 26.82 3 141899 23012 63324108
Injection site haemorrhage 39.92 26.82 4 141898 24310 63322810
Serotonin syndrome 39.47 26.82 8 141894 28674 63318446
Drug level increased 39.34 26.82 3 141899 22733 63324387
Hypertension 39.01 26.82 857 141045 278446 63068674
Neck pain 39.00 26.82 59 141843 69259 63277861
Blepharospasm 38.93 26.82 57 141845 5939 63341181
Device issue 38.81 26.82 4 141898 23777 63323343
Heart rate irregular 38.67 26.82 3 141899 22418 63324702
Anaphylactic shock 38.51 26.82 4 141898 23629 63323491
Shock 38.16 26.82 4 141898 23459 63323661
Urinary incontinence 38.14 26.82 12 141890 32002 63315118
Flatulence 37.93 26.82 15 141887 34687 63312433
Neoplasm malignant 37.77 26.82 10 141892 29851 63317269
Bursitis 37.32 26.82 173 141729 36868 63310252
Blood calcium decreased 37.19 26.82 7 141895 26444 63320676
Blindness 37.16 26.82 3 141899 21696 63325424
Altered state of consciousness 36.96 26.82 6 141896 25224 63321896
Joint dislocation 36.94 26.82 109 141793 18691 63328429
Eczema 36.90 26.82 13 141889 32278 63314842
Gastric ulcer 36.86 26.82 5 141897 24032 63323088
Laryngitis 36.86 26.82 102 141800 16865 63330255
Drug ineffective for unapproved indication 36.78 26.82 15 141887 34048 63313072
Abnormal behaviour 36.59 26.82 3 141899 21423 63325697
Cerebral infarction 36.57 26.82 5 141897 23888 63323232
Ulcer 36.52 26.82 7 141895 26100 63321020
Pollakiuria 36.02 26.82 9 141893 27928 63319192
Device dislocation 35.73 26.82 7 141895 25698 63321422
Osteonecrosis 35.56 26.82 6 141896 24524 63322596
Device related infection 35.55 26.82 5 141897 23387 63323733
Multiple sclerosis 35.25 26.82 6 141896 24366 63322754
Obstructive airways disorder 35.06 26.82 3 141899 20696 63326424
Sinus tachycardia 35.04 26.82 6 141896 24262 63322858
Lacrimation increased 34.92 26.82 3 141899 20628 63326492
Aphasia 34.88 26.82 15 141887 32985 63314135
Oral herpes 34.40 26.82 8 141894 26066 63321054
Osteoarthritis 34.38 26.82 345 141557 94998 63252122
Sciatica 34.35 26.82 160 141742 34164 63312956
Osteomyelitis 34.30 26.82 8 141894 26012 63321108
Feeling cold 34.28 26.82 6 141896 23882 63323238
Pulmonary mass 33.95 26.82 5 141897 22591 63324529
Pulmonary arterial hypertension 33.91 26.82 5 141897 22572 63324548
Psychotic disorder 33.70 26.82 8 141894 25704 63321416
Joint injury 33.63 26.82 12 141890 29560 63317560
Acute respiratory distress syndrome 33.58 26.82 6 141896 23528 63323592
Disturbance in attention 33.54 26.82 22 141880 38167 63308953
Vaginal haemorrhage 33.29 26.82 10 141892 27477 63319643
C-reactive protein abnormal 33.11 26.82 196 141706 45900 63301220
Cholelithiasis 32.63 26.82 30 141872 43895 63303225
Generalised tonic-clonic seizure 32.62 26.82 12 141890 29004 63318116
Coronary artery disease 32.23 26.82 16 141886 32361 63314759
Foot fracture 32.23 26.82 7 141895 23907 63323213
Hepatic steatosis 32.17 26.82 12 141890 28757 63318363
Hallucination, visual 32.14 26.82 3 141899 19295 63327825
Throat tightness 32.12 26.82 8 141894 24879 63322241
Chest pain 32.07 26.82 318 141584 215641 63131479
Eosinophilia 32.04 26.82 6 141896 22750 63324370
Skin laceration 31.95 26.82 6 141896 22702 63324418
Nightmare 31.93 26.82 3 141899 19191 63327929
Proteinuria 31.82 26.82 3 141899 19142 63327978
Disseminated intravascular coagulation 31.63 26.82 3 141899 19048 63328072
Eating disorder 31.56 26.82 3 141899 19013 63328107
Bone disorder 31.40 26.82 5 141897 21321 63325799
Glaucoma 31.32 26.82 3 141899 18902 63328218
Upper gastrointestinal haemorrhage 31.21 26.82 3 141899 18849 63328271
Dysstasia 31.08 26.82 5 141897 21161 63325959
Clostridium difficile infection 30.99 26.82 14 141888 29908 63317212
Haemorrhoids 30.85 26.82 6 141896 22144 63324976
Injection site mass 30.81 26.82 3 141899 18653 63328467
Urosepsis 30.53 26.82 3 141899 18521 63328599
Faeces discoloured 30.50 26.82 3 141899 18506 63328614
Eye irritation 30.50 26.82 6 141896 21965 63325155
Neuralgia 30.39 26.82 10 141892 25916 63321204
Eye swelling 30.27 26.82 8 141894 23910 63323210
Skin disorder 30.26 26.82 14 141888 29493 63317627
Blood potassium increased 30.09 26.82 3 141899 18306 63328814
Spinal fracture 30.01 26.82 3 141899 18268 63328852
Clostridium difficile colitis 29.89 26.82 5 141897 20564 63326556
Intervertebral disc protrusion 29.87 26.82 8 141894 23701 63323419
Gastroenteritis viral 29.86 26.82 8 141894 23692 63323428
Irritability 29.59 26.82 17 141885 31677 63315443
Product administration error 29.29 26.82 7 141895 22390 63324730
Adrenal insufficiency 29.27 26.82 3 141899 17912 63329208
Acne 29.08 26.82 8 141894 23285 63323835
Hemiparesis 29.06 26.82 8 141894 23274 63323846
Diabetes mellitus 29.05 26.82 50 141852 55760 63291360
Unresponsive to stimuli 29.00 26.82 20 141882 33796 63313324
Upper limb fracture 28.96 26.82 4 141898 18964 63328156
Ocular hyperaemia 28.94 26.82 10 141892 25134 63321986
Sopor 28.85 26.82 7 141895 22157 63324963
Musculoskeletal chest pain 28.76 26.82 6 141896 21077 63326043
Leukocytosis 28.69 26.82 11 141891 25924 63321196
White blood cell count increased 28.63 26.82 40 141862 48521 63298599
Dementia 28.61 26.82 4 141898 18790 63328330
Cardiomyopathy 28.59 26.82 3 141899 17581 63329539
Blood glucose decreased 28.51 26.82 6 141896 20946 63326174
Onychomycosis 28.48 26.82 58 141844 7874 63339246
Intestinal obstruction 28.24 26.82 17 141885 30882 63316238
Abdominal pain lower 28.23 26.82 11 141891 25667 63321453
Nail operation 28.15 26.82 20 141882 870 63346250
Diplopia 28.08 26.82 9 141893 23719 63323401
Wheezing 28.04 26.82 332 141570 95263 63251857
Muscle spasms 28.01 26.82 219 141683 155931 63191189
Bronchospasm 27.96 26.82 3 141899 17277 63329843
Coagulopathy 27.71 26.82 6 141896 20538 63326582
Therapeutic product effect incomplete 27.59 26.82 165 141737 124891 63222229
Caesarean section 27.45 26.82 3 141899 17029 63330091
Hepatitis 27.45 26.82 29 141873 39759 63307361
Sleep disorder 27.43 26.82 291 141611 81275 63265845
Complication associated with device 27.34 26.82 3 141899 16975 63330145
Panic attack 27.27 26.82 8 141894 22323 63324797
Musculoskeletal discomfort 26.94 26.82 4 141898 17963 63329157

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Sudden infant death syndrome 62.49 16.60 13 5521 235 34951162
Cardiac septal defect 53.71 16.60 12 5522 307 34951090
Kidney duplex 50.77 16.60 12 5522 396 34951001
Multiple allergies 47.92 16.60 18 5516 2985 34948412
Toxicity to various agents 43.53 16.60 97 5437 200265 34751132
Asthma-chronic obstructive pulmonary disease overlap syndrome 41.24 16.60 13 5521 1274 34950123
Symmetrical drug-related intertriginous and flexural exanthema 36.70 16.60 9 5525 348 34951049
Mycobacterial infection 33.46 16.60 13 5521 2361 34949036
Substance abuser 28.46 16.60 6 5528 116 34951281
Hypoxic-ischaemic encephalopathy 28.33 16.60 14 5520 4518 34946879
Sinusitis 17.82 16.60 27 5507 41375 34910022
Tachycardia 17.17 16.60 40 5494 84732 34866665

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pemphigus 2897.62 22.94 1733 102396 97849 79542410
Systemic lupus erythematosus 2677.57 22.94 1771 102358 119378 79520881
Pericarditis 2616.56 22.94 1651 102478 102585 79537674
Glossodynia 2559.41 22.94 1623 102506 101714 79538545
Hand deformity 2483.88 22.94 1596 102533 102323 79537936
Anti-cyclic citrullinated peptide antibody positive 2337.43 22.94 1416 102713 81727 79558532
Wound 2232.19 22.94 1558 102571 114621 79525638
Discomfort 1987.97 22.94 1498 102631 124119 79516140
Synovitis 1944.29 22.94 1593 102536 149141 79491118
Duodenal ulcer perforation 1897.20 22.94 1142 102987 65069 79575190
Helicobacter infection 1817.65 22.94 1132 102997 68572 79571687
Arthropathy 1787.82 22.94 1627 102502 175484 79464775
Alopecia 1747.20 22.94 1812 102317 229543 79410716
Abdominal discomfort 1647.17 22.94 1824 102305 248903 79391356
Swelling 1526.42 22.94 1636 102493 215075 79425184
Hepatic enzyme increased 1523.28 22.94 1510 102619 181100 79459159
Contraindicated product administered 1334.27 22.94 1314 102815 156224 79484035
Hypersensitivity 1319.12 22.94 1665 102464 260574 79379685
Maternal exposure during pregnancy 1302.10 22.94 1216 102913 135322 79504937
Infusion related reaction 1251.07 22.94 1520 102609 228717 79411542
Blister 1206.81 22.94 1099 103030 118377 79521882
Rheumatoid factor positive 1205.02 22.94 827 103302 59012 79581247
Drug intolerance 1201.61 22.94 1596 102533 262523 79377736
Folliculitis 1164.11 22.94 786 103343 54594 79585665
Irritable bowel syndrome 1145.43 22.94 814 103315 61427 79578832
Muscle injury 1143.81 22.94 740 103389 47821 79592438
Therapeutic product effect decreased 1058.40 22.94 1183 102946 162680 79477579
Joint swelling 1005.38 22.94 1536 102593 287110 79353149
Sleep disorder due to general medical condition, insomnia type 977.42 22.94 644 103485 42912 79597347
Impaired healing 812.37 22.94 769 103360 86886 79553373
Rheumatic fever 762.21 22.94 471 103658 28054 79612205
Treatment failure 680.04 22.94 968 103161 169518 79470741
Swollen joint count increased 626.33 22.94 384 103745 22543 79617716
Product use issue 610.72 22.94 1030 103099 208792 79431467
Stomatitis 592.06 22.94 838 103291 145919 79494340
Acute kidney injury 553.60 22.94 31 104098 519373 79120886
Lower respiratory tract infection 539.18 22.94 750 103379 128470 79511789
Blood cholesterol increased 520.16 22.94 593 103536 83127 79557132
Rheumatoid arthritis 488.12 22.94 931 103198 207539 79432720
Type 2 diabetes mellitus 483.45 22.94 477 103652 56645 79583614
Hip arthroplasty 480.83 22.94 388 103741 35368 79604891
Gastrointestinal disorder 479.75 22.94 689 103440 121516 79518743
Ill-defined disorder 459.83 22.94 496 103633 65379 79574880
Anaemia 457.77 22.94 32 104097 444983 79195276
Pain 440.37 22.94 1949 102180 701853 78938406
Death 416.32 22.94 113 104016 566401 79073858
Rash 406.56 22.94 1660 102469 576698 79063561
Liver injury 403.41 22.94 431 103698 56183 79584076
Hypotension 387.51 22.94 57 104072 440260 79199999
Knee arthroplasty 376.82 22.94 367 103762 42881 79597378
Fall 372.09 22.94 90 104039 487539 79152720
Sinusitis 354.57 22.94 786 103343 194715 79445544
Fibromyalgia 350.17 22.94 426 103703 63914 79576345
Psoriatic arthropathy 343.60 22.94 465 103664 77534 79562725
Musculoskeletal stiffness 342.91 22.94 726 103403 174282 79465977
Infection 340.52 22.94 881 103248 240831 79399428
Drug interaction 338.25 22.94 66 104063 415117 79225142
Injury 333.80 22.94 457 103672 77039 79563220
Adverse event 278.99 22.94 368 103761 59846 79580413
Neutropenia 275.57 22.94 28 104101 287682 79352577
Contusion 271.67 22.94 600 103529 148176 79492083
Thrombocytopenia 256.15 22.94 25 104104 265234 79375025
Sepsis 248.46 22.94 30 104099 269398 79370861
Nasopharyngitis 247.14 22.94 811 103318 253070 79387189
Pneumonia 243.81 22.94 303 103826 659943 78980316
Cough 240.90 22.94 89 104040 366700 79273559
Febrile neutropenia 233.28 22.94 18 104111 230981 79409278
Nausea 225.21 22.94 582 103547 956614 78683645
Prescribed overdose 221.12 22.94 260 103869 37623 79602636
Deep vein thrombosis postoperative 212.36 22.94 147 103982 10605 79629654
Diarrhoea 207.28 22.94 535 103594 879954 78760305
General physical health deterioration 206.95 22.94 808 103321 274430 79365829
Urinary tract infection 204.59 22.94 53 104076 274459 79365800
Lip dry 204.44 22.94 166 103963 15252 79625007
Facet joint syndrome 203.45 22.94 146 103983 11156 79629103
Intentional product use issue 201.28 22.94 542 103587 151570 79488689
Weight increased 193.08 22.94 795 103334 276591 79363668
Pancytopenia 192.80 22.94 5 104124 165740 79474519
Haemoglobin decreased 192.30 22.94 30 104099 222089 79418170
Adjustment disorder with depressed mood 183.63 22.94 126 104003 8960 79631299
Live birth 182.12 22.94 169 103960 18575 79621684
Disease progression 181.60 22.94 16 104113 184346 79455913
Exposure during pregnancy 181.28 22.94 405 103724 100727 79539532
Platelet count decreased 181.09 22.94 21 104108 194643 79445616
Somnolence 180.26 22.94 45 104084 238936 79401323
Hyponatraemia 179.14 22.94 14 104115 177834 79462425
Dehydration 179.13 22.94 51 104078 248136 79392123
Constipation 178.62 22.94 73 104056 282977 79357282
Mobility decreased 176.59 22.94 450 103679 121725 79518534
Arthralgia 173.52 22.94 1308 102821 570495 79069764
Cardiac failure 171.83 22.94 7 104122 154835 79485424
Peripheral swelling 170.79 22.94 751 103378 268866 79371393
Autoimmune disorder 165.71 22.94 152 103977 16460 79623799
Toxicity to various agents 162.19 22.94 187 103942 421353 79218906
Peripheral venous disease 161.49 22.94 147 103982 15762 79624497
Renal impairment 160.09 22.94 12 104117 157771 79482488
Atrial fibrillation 159.80 22.94 32 104097 197854 79442405
Confusional state 158.82 22.94 827 103302 317170 79323089
Product dose omission issue 157.54 22.94 63 104066 247474 79392785
Renal failure 157.16 22.94 35 104094 200933 79439326
Adverse drug reaction 155.62 22.94 297 103832 66095 79574164
Dislocation of vertebra 153.90 22.94 107 104022 7773 79632486
Grip strength decreased 153.07 22.94 165 103964 21704 79618555
Erythema 151.93 22.94 51 104078 223239 79417020
Back pain 151.58 22.94 106 104023 304074 79336185
Pregnancy 151.26 22.94 181 103948 26670 79613589
Anti-cyclic citrullinated peptide antibody 149.59 22.94 94 104035 5758 79634501
Retinitis 145.14 22.94 91 104038 5552 79634707
Malignant neoplasm progression 144.91 22.94 8 104121 135982 79504277
Bradycardia 141.33 22.94 9 104120 135548 79504711
Blood pressure increased 139.12 22.94 51 104078 211309 79428950
Blood creatinine increased 136.33 22.94 20 104109 155037 79485222
White blood cell count decreased 135.26 22.94 39 104090 188249 79452010
Multiple organ dysfunction syndrome 134.89 22.94 5 104124 120241 79520018
Osteoarthritis 132.84 22.94 328 103801 86981 79553278
Myocardial infarction 132.53 22.94 38 104091 184091 79456168
Joint range of motion decreased 132.38 22.94 189 103940 33093 79607166
Oxygen saturation decreased 130.38 22.94 10 104119 129037 79511222
Septic shock 128.48 22.94 8 104121 122793 79517466
Hyperkalaemia 127.49 22.94 5 104124 114393 79525866
Gastrointestinal haemorrhage 125.46 22.94 21 104108 147698 79492561
Hypokalaemia 123.40 22.94 20 104109 144020 79496239
Fatigue 122.23 22.94 1794 102335 927933 78712326
Cardiac failure congestive 121.48 22.94 20 104109 142382 79497877
Leukopenia 120.68 22.94 8 104121 116505 79523754
Syncope 120.30 22.94 42 104087 179407 79460852
Respiratory failure 118.46 22.94 44 104085 180867 79459392
Alanine aminotransferase increased 118.01 22.94 33 104096 162537 79477722
COVID-19 116.34 22.94 31 104098 157643 79482616
Hypoglycaemia 114.73 22.94 4 104125 101590 79538669
Seizure 112.28 22.94 53 104076 188781 79451478
Pleural effusion 110.17 22.94 27 104102 145235 79495024
Rhabdomyolysis 110.08 22.94 6 104123 103125 79537134
Breast cancer stage III 110.07 22.94 96 104033 9730 79630529
Myalgia 107.49 22.94 54 104075 185587 79454672
Asthenia 105.21 22.94 331 103798 511358 79128901
Aspartate aminotransferase increased 102.77 22.94 27 104102 138614 79501645
Tremor 100.71 22.94 48 104081 170035 79470224
Injection site pain 98.72 22.94 24 104105 129814 79510445
Loss of consciousness 98.52 22.94 48 104081 167895 79472364
Neuropathy peripheral 96.56 22.94 32 104097 141273 79498986
Maternal exposure timing unspecified 95.58 22.94 71 104058 5721 79634538
Hypoaesthesia 95.38 22.94 475 103654 178877 79461382
Drug ineffective 94.12 22.94 1953 102176 1078960 78561299
Lower limb fracture 94.04 22.94 133 103996 23082 79617177
Inappropriate schedule of product administration 93.55 22.94 29 104100 133599 79506660
Weight decreased 93.41 22.94 203 103926 354995 79285264
Cerebrovascular accident 93.21 22.94 43 104086 155249 79485010
Oropharyngeal pain 91.85 22.94 16 104113 109337 79530922
Chest discomfort 91.33 22.94 33 104096 138011 79502248
Vomiting 91.26 22.94 504 103625 665324 78974935
Cardiac arrest 91.05 22.94 56 104073 172040 79468219
Chills 90.69 22.94 48 104081 160186 79480073
Blood glucose increased 89.90 22.94 20 104109 114955 79525304
Bursitis 89.77 22.94 165 103964 35679 79604580
Wound infection 89.23 22.94 132 103997 23859 79616400
Influenza 89.18 22.94 29 104100 129577 79510682
Herpes zoster 86.63 22.94 10 104119 93073 79547186
Depressed level of consciousness 86.03 22.94 12 104117 96640 79543619
Abdominal pain 85.77 22.94 244 103885 389325 79250934
Hypoxia 84.78 22.94 16 104113 103227 79537032
Metabolic acidosis 84.49 22.94 6 104123 82523 79557736
Exostosis 84.24 22.94 107 104022 16751 79623508
Obesity 83.35 22.94 158 103971 34967 79605292
Drug abuse 83.24 22.94 55 104074 162636 79477623
Cellulitis 83.22 22.94 20 104109 109040 79531219
Completed suicide 83.07 22.94 120 104009 245647 79394612
Neutrophil count decreased 82.85 22.94 12 104117 93947 79546312
Blood pressure decreased 82.57 22.94 15 104114 99451 79540808
Hepatic function abnormal 82.12 22.94 3 104126 73104 79567155
C-reactive protein 82.09 22.94 61 104068 4918 79635341
Sciatica 80.77 22.94 151 103978 33071 79607188
Dyspnoea exertional 79.44 22.94 10 104119 87063 79553196
Lupus-like syndrome 79.01 22.94 94 104035 13763 79626496
Pruritus 78.55 22.94 824 103305 393824 79246435
Epistaxis 78.42 22.94 24 104105 111491 79528768
Interstitial lung disease 77.81 22.94 25 104104 112575 79527684
Hyperhidrosis 77.79 22.94 51 104078 151441 79488818
C-reactive protein abnormal 77.05 22.94 185 103944 48182 79592077
Electrocardiogram QT prolonged 76.40 22.94 13 104116 90373 79549886
Joint dislocation 76.06 22.94 102 104027 16837 79623422
Mucosal inflammation 75.93 22.94 6 104123 75574 79564685
Sleep disorder 75.51 22.94 265 103864 85412 79554847
Lactic acidosis 75.37 22.94 4 104125 70355 79569904
Bone erosion 73.40 22.94 103 104026 17744 79622515
Ascites 73.19 22.94 7 104122 75555 79564704
Heart rate increased 71.56 22.94 34 104095 120690 79519569
Haemorrhage 70.93 22.94 16 104113 91102 79549157
Walking aid user 70.02 22.94 76 104053 10072 79630187
Laryngitis 69.62 22.94 95 104034 15944 79624315
X-ray abnormal 69.59 22.94 59 104070 5754 79634505
Wrong technique in product usage process 68.59 22.94 8 104121 73867 79566392
Balance disorder 68.21 22.94 22 104107 98835 79541424
International normalised ratio increased 67.73 22.94 14 104115 84707 79555552
Pulmonary oedema 67.70 22.94 16 104113 88238 79552021
Haematuria 67.68 22.94 6 104123 68830 79571429
Night sweats 67.18 22.94 184 103945 51911 79588348
Pulmonary embolism 67.14 22.94 75 104054 171579 79468680
Seronegative arthritis 65.34 22.94 52 104077 4640 79635619
Oedema 65.17 22.94 319 103810 119261 79520998
Feeling abnormal 65.11 22.94 67 104062 159132 79481127
Coma 64.99 22.94 25 104104 100624 79539635
Blood bilirubin increased 64.51 22.94 6 104123 66226 79574033
Heart rate decreased 64.33 22.94 8 104121 70308 79569951
Tachycardia 62.85 22.94 84 104045 177684 79462575
Blood pressure systolic increased 62.82 22.94 7 104122 66979 79573280
Pneumonia aspiration 62.80 22.94 7 104122 66960 79573299
Lupus vulgaris 62 22.94 44 104085 3302 79636957
Off label use 61.41 22.94 826 103303 906389 78733870
Encephalopathy 60.85 22.94 8 104121 67389 79572870
Vertigo 60.49 22.94 9 104120 69073 79571186
Onychomadesis 60.30 22.94 52 104077 5190 79635069
Drug reaction with eosinophilia and systemic symptoms 59.53 22.94 7 104122 64237 79576022
Dysarthria 58.78 22.94 9 104120 67613 79572646
Blood pressure fluctuation 58.22 22.94 9 104120 67136 79573123
Melaena 58.03 22.94 6 104123 60884 79579375
Disorientation 57.78 22.94 7 104122 62769 79577490
Hyperglycaemia 57.53 22.94 11 104118 70324 79569935
Thrombosis 57.52 22.94 19 104110 84081 79556178
Haemoptysis 57.52 22.94 4 104125 55995 79584264
Blepharospasm 57.30 22.94 53 104076 5798 79634461
Acute respiratory failure 56.40 22.94 6 104123 59535 79580724
Dysphagia 56.35 22.94 46 104083 122090 79518169
Haematochezia 56.21 22.94 22 104107 87623 79552636
Overdose 55.54 22.94 97 104032 184109 79456150
Hypercholesterolaemia 54.93 22.94 104 104025 22991 79617268
Incorrect dose administered 54.77 22.94 16 104113 76614 79563645
Palpitations 54.41 22.94 51 104078 126559 79513700
Foot deformity 54.31 22.94 106 104023 23968 79616291
Abdominal distension 54.05 22.94 46 104083 119604 79520655
Pain in extremity 53.69 22.94 269 103860 364269 79275990
Flushing 53.64 22.94 24 104105 88244 79552015
Gamma-glutamyltransferase increased 53.13 22.94 5 104124 54675 79585584
Condition aggravated 53.07 22.94 934 103195 500190 79140069
Influenza like illness 53.06 22.94 14 104115 71693 79568566
Hypocalcaemia 52.97 22.94 3 104126 49921 79590338
Injection site erythema 52.90 22.94 18 104111 78179 79562080
Blood creatine phosphokinase increased 52.67 22.94 11 104118 66079 79574180
Intentional overdose 52.61 22.94 37 104092 105923 79534336
Pancreatitis acute 52.57 22.94 3 104126 49601 79590658
Respiratory distress 52.49 22.94 7 104122 58332 79581927
Sudden infant death syndrome 52.19 22.94 18 104111 267 79639992
Productive cough 52.16 22.94 25 104104 88306 79551953
Hepatotoxicity 51.80 22.94 4 104125 51348 79588911
Red blood cell count decreased 51.51 22.94 7 104122 57506 79582753
Vision blurred 51.24 22.94 38 104091 105860 79534399
Lethargy 51.16 22.94 21 104108 81271 79558988
Cognitive disorder 51.08 22.94 14 104115 69912 79570347
Wheezing 51.08 22.94 293 103836 116371 79523888
Pulmonary hypertension 50.68 22.94 3 104126 48077 79592182
Hepatocellular injury 50.07 22.94 3 104126 47590 79592669
Road traffic accident 49.28 22.94 147 103982 43517 79596742
Hypomagnesaemia 49.22 22.94 3 104126 46908 79593351
Hepatic failure 49.17 22.94 10 104119 61202 79579057
Plasma cell myeloma 48.86 22.94 6 104123 53253 79587006
Acute myocardial infarction 48.32 22.94 20 104109 77016 79563243
Gait inability 48.30 22.94 178 103951 58739 79581520
Agitation 47.97 22.94 36 104093 99679 79540580
Haematemesis 47.68 22.94 6 104123 52258 79588001
Rash pruritic 47.57 22.94 17 104112 71612 79568647
Cardio-respiratory arrest 47.46 22.94 43 104086 108467 79531792
Angioedema 47.27 22.94 20 104109 76015 79564244
Cerebral haemorrhage 47.21 22.94 9 104120 57664 79582595
Liver function test abnormal 46.93 22.94 13 104116 64462 79575797
Agranulocytosis 46.89 22.94 3 104126 45027 79595232
Lymphocyte count decreased 46.82 22.94 4 104125 47285 79592974
Cardiac disorder 46.50 22.94 14 104115 65743 79574516
Toxic epidermal necrolysis 46.33 22.94 3 104126 44578 79595681
Blood alkaline phosphatase increased 46.03 22.94 13 104116 63651 79576608
Colitis 46.03 22.94 19 104110 73288 79566971
Rectal haemorrhage 45.97 22.94 21 104108 76279 79563980
Orthostatic hypotension 45.48 22.94 9 104120 56155 79584104
Rash maculo-papular 45.38 22.94 9 104120 56069 79584190
Suicide attempt 45.23 22.94 26 104103 82906 79557353
Drug tolerance decreased 44.84 22.94 69 104060 12909 79627350
Transaminases increased 44.71 22.94 7 104122 51736 79588523
Osteonecrosis of jaw 44.65 22.94 3 104126 43223 79597036
Blood urea increased 43.55 22.94 6 104123 48784 79591475
Chronic obstructive pulmonary disease 43.51 22.94 29 104100 85390 79554869
Chronic kidney disease 43.43 22.94 16 104113 66138 79574121
Haematoma 43.03 22.94 8 104121 52187 79588072
Pneumonitis 42.96 22.94 13 104116 60847 79579412
Bone pain 42.96 22.94 10 104119 55732 79584527
Rhinorrhoea 42.72 22.94 23 104106 76051 79564208
Jaundice 42.26 22.94 9 104120 53340 79586919
Stress 41.95 22.94 26 104103 79586 79560673
Prescribed underdose 41.85 22.94 108 104021 29406 79610853
Cystitis 41.56 22.94 9 104120 52723 79587536
Suicidal ideation 41.54 22.94 24 104105 76316 79563943
Skin ulcer 41.17 22.94 10 104119 54140 79586119
Mental status changes 41.01 22.94 18 104111 66941 79573318
Psoriasis 41.00 22.94 34 104095 89553 79550706
Drug hypersensitivity 40.21 22.94 580 103549 298336 79341923
Urinary retention 40.14 22.94 12 104117 56618 79583641
Altered state of consciousness 40.05 22.94 5 104124 43817 79596442
Haematocrit decreased 39.96 22.94 15 104114 61297 79578962
Presyncope 39.24 22.94 4 104125 41050 79599209
Hypothyroidism 39.20 22.94 10 104119 52382 79587877
Cataract 39.16 22.94 16 104113 62104 79578155
Hypercalcaemia 38.74 22.94 3 104126 38427 79601832
Multiple sclerosis relapse 38.65 22.94 7 104122 46526 79593733
Pericardial effusion 38.31 22.94 7 104122 46230 79594029
Anaphylactic reaction 38.06 22.94 32 104097 83711 79556548
Renal disorder 38.00 22.94 5 104124 42100 79598159
Rash erythematous 37.87 22.94 14 104115 57755 79582504
Localised infection 37.69 22.94 3 104126 37572 79602687
Transient ischaemic attack 37.66 22.94 11 104118 52684 79587575
Bronchitis 37.40 22.94 71 104058 130573 79509686
Eosinophilia 37.28 22.94 7 104122 45338 79594921
Injection site swelling 37.24 22.94 8 104121 47124 79593135
Deep vein thrombosis 37.05 22.94 63 104066 120856 79519403
Disability 36.95 22.94 74 104055 17046 79623213
Dysphonia 36.92 22.94 14 104115 56858 79583401
Skin exfoliation 36.72 22.94 13 104116 55087 79585172
Pancreatitis 36.69 22.94 22 104107 68553 79571706
Pallor 36.61 22.94 10 104119 50052 79590207
Mouth ulceration 36.03 22.94 4 104125 38390 79601869
Onychomycosis 35.95 22.94 49 104080 8212 79632047
Tubulointerstitial nephritis 35.84 22.94 4 104125 38231 79602028
Acute respiratory distress syndrome 35.81 22.94 7 104122 44060 79596199
Cytokine release syndrome 35.76 22.94 3 104126 35995 79604264
Cerebral infarction 35.58 22.94 8 104121 45668 79594591
Cardiogenic shock 35.48 22.94 6 104123 41908 79598351
Hypophagia 35.24 22.94 8 104121 45359 79594900
Coronary artery disease 35.03 22.94 21 104108 65453 79574806
Therapy cessation 35.03 22.94 4 104125 37558 79602701
Upper gastrointestinal haemorrhage 34.86 22.94 6 104123 41374 79598885
Dyskinesia 34.56 22.94 8 104121 44765 79595494
Stevens-Johnson syndrome 34.53 22.94 5 104124 39161 79601098
Skin discolouration 34.46 22.94 6 104123 41028 79599231
Gastritis 34.33 22.94 10 104119 47983 79592276
Dysuria 33.99 22.94 12 104117 50939 79589320
Therapy non-responder 33.56 22.94 221 103908 92084 79548175
Sedation 33.31 22.94 13 104116 51882 79588377
Skin lesion 33.27 22.94 7 104122 41837 79598422
Gastric ulcer 33.21 22.94 3 104126 33902 79606357
Anaphylactic shock 33.16 22.94 4 104125 35992 79604267
Angina pectoris 33.14 22.94 13 104116 51719 79588540
Lymphadenopathy 33.11 22.94 14 104115 53233 79587026
Depressed mood 33.07 22.94 11 104118 48469 79591790
Serotonin syndrome 32.92 22.94 9 104120 45018 79595241
Dry mouth 32.77 22.94 212 103917 87807 79552452
Blood potassium decreased 32.71 22.94 10 104119 46502 79593757
Dysgeusia 32.52 22.94 17 104112 57160 79583099
Burning sensation 32.52 22.94 18 104111 58614 79581645
Musculoskeletal deformity 32.44 22.94 22 104107 1534 79638725
Staphylococcal infection 32.18 22.94 18 104111 58277 79581982
Drug eruption 31.71 22.94 9 104120 43926 79596333
Nephrolithiasis 31.58 22.94 15 104114 53276 79586983
Respiratory tract infection 31.58 22.94 12 104117 48677 79591582
Pneumocystis jirovecii pneumonia 31.51 22.94 3 104126 32505 79607754
Ventricular tachycardia 31.38 22.94 8 104121 41927 79598332
Hallucination 30.82 22.94 40 104089 85705 79554554
Ear infection 30.75 22.94 107 104022 34325 79605934
Spinal fusion surgery 30.63 22.94 36 104093 5202 79635057
Disseminated intravascular coagulation 30.63 22.94 5 104124 35837 79604422
Injection site bruising 30.34 22.94 8 104121 40994 79599265
Diverticulitis 30.34 22.94 11 104118 45925 79594334
Throat irritation 30.28 22.94 8 104121 40938 79599321
Head injury 30.23 22.94 6 104123 37363 79602896
Prostate cancer 29.91 22.94 4 104125 33264 79606995
Speech disorder 29.78 22.94 17 104112 54428 79585831
Malaise 29.49 22.94 456 103673 489413 79150846
Hip fracture 29.39 22.94 3 104126 30758 79609501
Lung disorder 29.36 22.94 193 103936 80364 79559895
Illness 29.29 22.94 12 104117 46499 79593760
Proteinuria 29 22.94 4 104125 32498 79607761
Intentional self-injury 28.90 22.94 4 104125 32415 79607844
Intentional product misuse 28.77 22.94 50 104079 95115 79545144
Body temperature decreased 28.58 22.94 4 104125 32141 79608118
Injection site pruritus 28.14 22.94 10 104119 42273 79597986
Unevaluable event 28.13 22.94 19 104110 55566 79584693
Femur fracture 27.74 22.94 8 104121 38644 79601615
Neutrophil count increased 27.74 22.94 3 104126 29393 79610866
Nail disorder 27.73 22.94 53 104076 11799 79628460
Accidental exposure to product 27.61 22.94 4 104125 31318 79608941
Fungal infection 27.57 22.94 10 104119 41738 79598521
Palmar-plantar erythrodysaesthesia syndrome 27.48 22.94 5 104124 33129 79607130
Ischaemic stroke 27.48 22.94 5 104124 33126 79607133
Hot flush 27.45 22.94 19 104110 54858 79585401
Pulmonary mass 27.31 22.94 3 104126 29031 79611228
Red cell distribution width decreased 27.13 22.94 22 104107 2016 79638243
Arrhythmia 27.13 22.94 24 104105 61248 79579011
Tinnitus 27.02 22.94 12 104117 44321 79595938
Cardiomyopathy 27.00 22.94 3 104126 28771 79611488
Product label confusion 26.98 22.94 20 104109 1606 79638653
Swelling face 26.87 22.94 32 104097 71180 79569079
Device related infection 26.73 22.94 6 104123 34288 79605971
Coagulopathy 26.69 22.94 7 104122 35999 79604260
Adrenal insufficiency 26.65 22.94 3 104126 28484 79611775
Drug ineffective for unapproved indication 26.63 22.94 17 104112 51221 79589038
Medication error 26.58 22.94 167 103962 68475 79571784
Eye pain 26.57 22.94 8 104121 37570 79602689
Blindness 26.53 22.94 3 104126 28380 79611879
Gastroenteritis 26.49 22.94 6 104123 34076 79606183
Metastases to liver 26.44 22.94 3 104126 28311 79611948
Acute hepatic failure 26.19 22.94 4 104125 30109 79610150
Restlessness 26.18 22.94 14 104115 46478 79593781
Dyspnoea 25.96 22.94 888 103241 856137 78784122
Pain in jaw 25.84 22.94 14 104115 46137 79594122
Sinus tachycardia 25.84 22.94 8 104121 36900 79603359
Vascular access complication 25.82 22.94 22 104107 2160 79638099
Fluid retention 25.67 22.94 32 104097 69777 79570482
Myoclonus 25.66 22.94 3 104126 27657 79612602
Viral infection 25.66 22.94 12 104117 43004 79597255
Blood sodium decreased 25.56 22.94 6 104123 33249 79607010
Limb injury 25.50 22.94 4 104125 29524 79610735
Candida infection 25.49 22.94 9 104120 38205 79602054
Abortion spontaneous 25.48 22.94 4 104125 29503 79610756
Drug level increased 25.34 22.94 10 104119 39641 79600618
Lip swelling 25.05 22.94 11 104118 40900 79599359
COVID-19 pneumonia 24.71 22.94 4 104125 28845 79611414
Shock 24.69 22.94 13 104116 43535 79596724
Joint stiffness 24.47 22.94 112 104017 40718 79599541
Tachypnoea 24.22 22.94 6 104123 32057 79608202
Hepatic cirrhosis 24.17 22.94 100 104029 34806 79605453
Dry skin 24.15 22.94 32 104097 67963 79572296
Pulmonary arterial hypertension 24.14 22.94 4 104125 28362 79611897
Neoplasm malignant 23.93 22.94 6 104123 31804 79608455
Clostridium difficile infection 23.82 22.94 13 104116 42672 79597587
Aphasia 23.61 22.94 16 104113 46716 79593543
Generalised tonic-clonic seizure 23.61 22.94 14 104115 43896 79596363
Disturbance in attention 23.59 22.94 19 104110 50782 79589477
Spondylitis 23.59 22.94 30 104099 4701 79635558
Injection site haemorrhage 23.57 22.94 4 104125 27866 79612393
Dizziness 23.55 22.94 516 103613 525925 79114334
Subdural haematoma 23.51 22.94 6 104123 31428 79608831
Urinary incontinence 23.51 22.94 12 104117 40897 79599362
Sopor 23.39 22.94 7 104122 33003 79607256
Bacterial infection 23.34 22.94 6 104123 31274 79608985
Labelled drug-drug interaction medication error 23.31 22.94 4 104125 27646 79612613
Osteomyelitis 23.23 22.94 7 104122 32858 79607401
Heart rate irregular 23.02 22.94 7 104122 32672 79607587

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC R01BA02 RESPIRATORY SYSTEM
NASAL PREPARATIONS
NASAL DECONGESTANTS FOR SYSTEMIC USE
Sympathomimetics
ATC R01BA52 RESPIRATORY SYSTEM
NASAL PREPARATIONS
NASAL DECONGESTANTS FOR SYSTEMIC USE
Sympathomimetics
FDA MoA N0000000209 Adrenergic alpha-Agonists
FDA EPC N0000175552 alpha-Adrenergic Agonist
CHEBI has role CHEBI:35470 central nervous system agents
CHEBI has role CHEBI:35523 bronchodilator
CHEBI has role CHEBI:35524 sympathomimetic
CHEBI has role CHEBI:35703 Xenobiotic
CHEBI has role CHEBI:49167 anti-asthmatic drugs
CHEBI has role CHEBI:76924 plant metabolites
CHEBI has role CHEBI:77715 nasal decongestants
MeSH PA D018927 Anti-Asthmatic Agents
MeSH PA D001993 Bronchodilator Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D014663 Nasal Decongestants
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D019141 Respiratory System Agents
MeSH PA D014662 Vasoconstrictor Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Sinus headache indication 4969004
Vasomotor rhinitis indication 8229003 DOID:4730
Allergic rhinitis indication 61582004
Nasal discharge indication 64531003
Nasal congestion indication 68235000
Rhinitis indication 70076002 DOID:4483
Common cold indication 82272006 DOID:10459
Headache disorder indication 230461009
Influenza-like symptoms indication 315642008
Seasonal allergic rhinitis indication 367498001
Allergic conjunctivitis indication 473460002 DOID:11204
Eustachian Tube Congestion indication
Brain damage contraindication 2470005
Ocular hypertension contraindication 4210003 DOID:9282
Tachyarrhythmia contraindication 6285003
Suicidal thoughts contraindication 6471006
Dependent drug abuse contraindication 6525002
Urinary tract obstruction contraindication 7163005 DOID:5200
Alcoholism contraindication 7200002
Alcohol withdrawal delirium contraindication 8635005
Peptic ulcer contraindication 13200003 DOID:750
Chronic obstructive lung disease contraindication 13645005 DOID:3083
Asthenia contraindication 13791008
Hyperkalemia contraindication 14140009
Severe chronic ulcerative colitis contraindication 14311001
Constipation contraindication 14760008 DOID:2089
Disorder of autonomic nervous system contraindication 15241006
Chronic disease of respiratory system contraindication 17097001
Mood swings contraindication 18963009
Pulmonary edema contraindication 19242006 DOID:11396
Myocardial infarction contraindication 22298006 DOID:5844
Glaucoma contraindication 23986001 DOID:1686
Inflammatory bowel disease contraindication 24526004 DOID:0050589
Ventricular tachycardia contraindication 25569003
Alcohol intoxication contraindication 25702006
Shock contraindication 27942005
Toxic megacolon contraindication 28536002 DOID:1770
Atony of colon contraindication 29479008
Hypercapnia contraindication 29596007
Dehydration contraindication 34095006
Hyperthyroidism contraindication 34486009 DOID:7998
Acute hepatitis contraindication 37871000
Hypertensive disorder contraindication 38341003 DOID:10763
Hypovolemic shock contraindication 39419009
Disorder of gallbladder contraindication 39621005 DOID:0060262
Gastrointestinal ulcer contraindication 40845000
Hypothyroidism contraindication 40930008 DOID:1459
Complete trisomy 21 syndrome contraindication 41040004 DOID:14250
Third trimester pregnancy contraindication 41587001
Body fluid retention contraindication 43498006
Conduction disorder of the heart contraindication 44808001
Low blood pressure contraindication 45007003
Achalasia of esophagus contraindication 45564002 DOID:9164
Chronic heart failure contraindication 48447003
Bradycardia contraindication 48867003
Disorder of cardiovascular system contraindication 49601007 DOID:1287
Acidosis contraindication 51387008
Gastrointestinal perforation contraindication 51875005
Coronary arteriosclerosis contraindication 53741008 DOID:3393
Paralytic ileus contraindication 55525008 DOID:8442
Peptic reflux disease contraindication 57643001
Multiple organ failure contraindication 57653000
Acute nephropathy contraindication 58574008
Metabolic acidosis contraindication 59455009
Hepatic failure contraindication 59927004
Ulcerative colitis contraindication 64766004 DOID:8577
Blood coagulation disorder contraindication 64779008 DOID:1247
Arterial thrombosis contraindication 65198009
Drug AND/OR toxin-induced diarrhea contraindication 65979008
Substance abuse contraindication 66214007
Benign intracranial hypertension contraindication 68267002 DOID:11459
Poisoning by acetaminophen contraindication 70273001
Arteriosclerotic vascular disease contraindication 72092001
Diabetes mellitus contraindication 73211009 DOID:9351
Gastrointestinal hemorrhage contraindication 74474003
Urethral stricture contraindication 76618002
Spastic paralysis contraindication 78403003
Disturbance of salivary secretion contraindication 78948009
Decreased respiratory function contraindication 80954004
Injury of head contraindication 82271004
Chronic idiopathic constipation contraindication 82934008
Cor pulmonale contraindication 83291003 DOID:8515
Hiatal hernia contraindication 84089009 DOID:12642
Epilepsy contraindication 84757009 DOID:1826
Pulmonary emphysema contraindication 87433001
Kidney disease contraindication 90708001 DOID:557
Myasthenia gravis contraindication 91637004 DOID:437
Acute abdominal pain contraindication 116290004
Procedure on urinary system contraindication 118677009
Gastrointestinal obstruction contraindication 126765001
Neoplasm of brain contraindication 126952004 DOID:1319
Seizure disorder contraindication 128613002
Autonomic dysreflexia contraindication 129618003
Bleeding contraindication 131148009
Liver function tests abnormal contraindication 166603001
Cystic fibrosis contraindication 190905008 DOID:1485
Drug-induced psychosis contraindication 191483003 DOID:1742
Angina pectoris contraindication 194828000
Partial atrioventricular block contraindication 195039008
Acute pancreatitis contraindication 197456007 DOID:2913
Impaired renal function disorder contraindication 197663003
Cerebrovascular accident contraindication 230690007
Coronary artery bypass graft contraindication 232717009
Myocardial dysfunction contraindication 233928007
Gastroesophageal reflux disease contraindication 235595009 DOID:8534
Disease of liver contraindication 235856003 DOID:409
Hyporeninemic hypoaldosteronism contraindication 236464008
Bladder outflow obstruction contraindication 236645006
Morbid obesity contraindication 238136002 DOID:11981
Sepsis syndrome contraindication 238150007
Rhabdomyolysis contraindication 240131006
Pyloric obstruction contraindication 244815007
Esophageal dysmotility contraindication 266434009 DOID:9192
Benign prostatic hyperplasia contraindication 266569009
Edema contraindication 267038008
Retention of urine contraindication 267064002
Anemia contraindication 271737000 DOID:2355
Continuous fever contraindication 271751000
Drowsy contraindication 271782001
Exacerbation of asthma contraindication 281239006
Pregnancy, function contraindication 289908002
Lesion of brain contraindication 301766008
Thromboembolic disorder contraindication 371039008
Coma contraindication 371632003
Primary adrenocortical insufficiency contraindication 373662000
Smoking cessation assistance contraindication 384742004
Operation on gastrointestinal tract contraindication 386621005
Hypoxia contraindication 389086002
Angle-closure glaucoma contraindication 392291006 DOID:13550
Cardiovascular event risk contraindication 395112001
Pseudomembranous enterocolitis contraindication 397683000
Gastric ulcer contraindication 397825006 DOID:10808
Breastfeeding (mother) contraindication 413712001
Chronic lung disease contraindication 413839001
Disorder of coronary artery contraindication 414024009
Traumatic injury contraindication 417746004
Central nervous system depression contraindication 418072004
Ultrarapid metabolizer due to cytochrome p450 CYP2D6 variant contraindication 422681000
Fever greater than 100.4 Fahrenheit contraindication 426000000
Dysfunction of sphincter of Oddi contraindication 430887001
Hypertensive urgency contraindication 443482000
Smokes tobacco daily contraindication 449868002
Acute exacerbation of asthma contraindication 708038006
Acute Thromboembolic Stroke contraindication
Theophylline Toxicity contraindication
Severe Hypoxemia contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.22 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Sodium-dependent noradrenaline transporter Transporter RELEASING AGENT CHEMBL CHEMBL
Alpha-1A adrenergic receptor GPCR WOMBAT-PK
Beta-2 adrenergic receptor GPCR WOMBAT-PK
Alpha-2A adrenergic receptor GPCR WOMBAT-PK

External reference:

IDSource
4018571 VUID
N0000178581 NUI
D00485 KEGG_DRUG
345-78-8 SECONDARY_CAS_RN
7460-12-0 SECONDARY_CAS_RN
4018043 VANDF
4018571 VANDF
4018802 VANDF
C0033798 UMLSCUI
CHEBI:51209 CHEBI
CHEMBL1590 ChEMBL_ID
DB00852 DRUGBANK_ID
CHEMBL1200724 ChEMBL_ID
CHEMBL3989855 ChEMBL_ID
D054199 MESH_DESCRIPTOR_UI
7028 PUBCHEM_CID
1061 INN_ID
7286 IUPHAR_LIGAND_ID
7CUC9DDI9F UNII
407885 RXNORM
2354 MMSL
5382 MMSL
5383 MMSL
5384 MMSL
d00769 MMSL
001831 NDDF
001832 NDDF
001833 NDDF
005972 NDDF
10595003 SNOMEDCT_US
12177002 SNOMEDCT_US
372900003 SNOMEDCT_US
91435002 SNOMEDCT_US
CHEMBL1201483 ChEMBL_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Dimetapp HUMAN OTC DRUG LABEL 2 0031-2231 ELIXIR 15 mg ORAL Export only 15 sections
Dimetapp HUMAN OTC DRUG LABEL 2 0031-2231 ELIXIR 15 mg ORAL Export only 15 sections
Dimetapp Paediatric HUMAN OTC DRUG LABEL 2 0031-2251 ELIXIR 15 mg ORAL Export only 1 sections
Dimetapp Paediatric HUMAN OTC DRUG LABEL 2 0031-2251 ELIXIR 15 mg ORAL Export only 1 sections
Robitussin CF HUMAN OTC DRUG LABEL 3 0031-8678 LIQUID 30 mg ORAL Export only 15 sections
Robitussin CF HUMAN OTC DRUG LABEL 3 0031-8678 LIQUID 30 mg ORAL Export only 15 sections
Good Sense Suphedrine12 Hour HUMAN OTC DRUG LABEL 1 0113-0054 TABLET, FILM COATED, EXTENDED RELEASE 120 mg ORAL ANDA 14 sections
good sense all day allergy d HUMAN OTC DRUG LABEL 2 0113-0147 TABLET, FILM COATED, EXTENDED RELEASE 120 mg ORAL ANDA 16 sections
Good Sense All Day Allergy D HUMAN OTC DRUG LABEL 2 0113-0176 TABLET, EXTENDED RELEASE 120 mg ORAL ANDA 16 sections
Zephrex D HUMAN OTC DRUG LABEL 1 0113-0401 CAPSULE, GELATIN COATED 30 mg ORAL OTC monograph final 14 sections
Good Sense Nasal Decongestant HUMAN OTC DRUG LABEL 1 0113-0432 TABLET, FILM COATED 30 mg ORAL OTC monograph final 15 sections
Mucus D HUMAN OTC DRUG LABEL 2 0113-2002 TABLET 60 mg ORAL ANDA 14 sections
Allergy and Congestion Relief HUMAN OTC DRUG LABEL 2 0113-2007 TABLET, FILM COATED, EXTENDED RELEASE 120 mg ORAL ANDA 14 sections
sinus congestion HUMAN OTC DRUG LABEL 1 0113-2008 TABLET, FILM COATED 30 mg ORAL OTC monograph final 15 sections
sinus 12 hour HUMAN OTC DRUG LABEL 1 0113-2017 TABLET, FILM COATED, EXTENDED RELEASE 120 mg ORAL ANDA 15 sections
sinus 12 hour HUMAN OTC DRUG LABEL 1 0113-2017 TABLET, FILM COATED, EXTENDED RELEASE 120 mg ORAL ANDA 15 sections
All Day Allergy-D HUMAN OTC DRUG LABEL 2 0113-2176 TABLET, EXTENDED RELEASE 120 mg ORAL ANDA 16 sections
perrigo allergy d HUMAN OTC DRUG LABEL 2 0113-7777 TABLET, FILM COATED, EXTENDED RELEASE 120 mg ORAL ANDA 15 sections
Brompheniramine Maleate, Pseudoephedrine Hydrochloride and Dextromethorphan Hydrobromide HUMAN PRESCRIPTION DRUG LABEL 3 0121-0933 SOLUTION 30 mg ORAL ANDA 21 sections
Brompheniramine Maleate, Pseudoephedrine Hydrochloride and Dextromethorphan Hydrobromide HUMAN PRESCRIPTION DRUG LABEL 3 0121-0933 SOLUTION 30 mg ORAL ANDA 21 sections
Aleve-D Sinus and Headache HUMAN OTC DRUG LABEL 2 0280-6045 TABLET 120 mg ORAL ANDA 17 sections
Aleve-D Sinus and Headache HUMAN OTC DRUG LABEL 2 0280-6045 TABLET 120 mg ORAL ANDA 17 sections
Aleve-D Sinus and Cold HUMAN OTC DRUG LABEL 2 0280-6090 TABLET 120 mg ORAL ANDA 17 sections
Aleve-D Sinus and Cold HUMAN OTC DRUG LABEL 2 0280-6090 TABLET 120 mg ORAL ANDA 17 sections
Fexofenadine Hydrochloride and Pseudoephedrine Hydrochloride HUMAN OTC DRUG LABEL 2 0363-0044 TABLET, EXTENDED RELEASE 120 mg ORAL ANDA 14 sections
Fexofenadine HCl and Pseudoephedrine HCl HUMAN OTC DRUG LABEL 2 0363-0049 TABLET, EXTENDED RELEASE 240 mg ORAL ANDA 15 sections
walphed dmaximum strength non drowsy sinus HUMAN OTC DRUG LABEL 1 0363-0061 TABLET, FILM COATED, EXTENDED RELEASE 120 mg ORAL ANDA 14 sections
Guaifenesin and Pseudoephedrine Hydrochloride HUMAN OTC DRUG LABEL 2 0363-0077 TABLET, EXTENDED RELEASE 60 mg ORAL NDA 16 sections
Fexofenadine Hydrochloride and Pseudoephedrine Hydrochloride Human OTC Drug Label 2 0363-0094 TABLET, FILM COATED, EXTENDED RELEASE 120 mg ORAL ANDA 11 sections
Fexofenadine Hydrochloride and Pseudoephedrine Hydrochloride Human OTC Drug Label 2 0363-0094 TABLET, FILM COATED, EXTENDED RELEASE 120 mg ORAL ANDA 11 sections