progesterone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
steroids, progestogens	2279	57-83-0

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: progesterone gestone gestormone glanducorpin lugesteron lugesterone progestan progeston progestone progestron progesterol syngesterone	The major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTERUS, the MAMMARY GLANDS and the BRAIN. It is required in EMBRYO IMPLANTATION; PREGNANCY maintenance, and the development of mammary tissue for MILK production. Progesterone, converted from PREGNENOLONE, also serves as an intermediate in the biosynthesis of GONADAL STEROID HORMONES and adrenal CORTICOSTEROIDS. Molecular weight: 314.47 Formula: C21H30O2 CLOGP: 3.96 LIPINSKI: 0 HAC: 2 HDO: 0 TPSA: 34.14 ALOGS: -4.76 ROTB: 1 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

progesterone
gestone
gestormone
glanducorpin
lugesteron
lugesterone
progestan
progeston
progestone
progestron
progesterol
syngesterone

The major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTERUS, the MAMMARY GLANDS and the BRAIN. It is required in EMBRYO IMPLANTATION; PREGNANCY maintenance, and the development of mammary tissue for MILK production. Progesterone, converted from PREGNENOLONE, also serves as an intermediate in the biosynthesis of GONADAL STEROID HORMONES and adrenal CORTICOSTEROIDS.

Molecular weight: 314.47
Formula: C21H30O2
CLOGP: 3.96
LIPINSKI: 0
HAC: 2
HDO: 0
TPSA: 34.14
ALOGS: -4.76
ROTB: 1

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
0.30	g	O
5	mg	P
0.20	g	R
90	mg	V

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	2	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	0.01 mg/mL	Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine)	0 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	21.20 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability)	25 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

Date	Agency	Company	Orphan
Feb. 4, 1976	FDA	ALZA
Sept. 27, 2021	PMDA	FUJI PHARMA CO., LTD.

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Ovarian hyperstimulation syndrome	960.36	12.65	246	28954	3768	63456054
Temperature regulation disorder	501.54	12.65	163	29037	5969	63453853
Food allergy	413.21	12.65	166	29034	11235	63448587
Coeliac disease	391.34	12.65	165	29035	12632	63447190
Exposure during pregnancy	319.38	12.65	375	28825	155172	63304650
Immunodeficiency	318.99	12.65	165	29035	20089	63439733
Bursitis	245.46	12.65	173	29027	36868	63422954
Rash erythematous	235.14	12.65	178	29022	42332	63417490
Premature labour	208.82	12.65	106	29094	12398	63447424
Foetal exposure during pregnancy	204.18	12.65	146	29054	31816	63428006
Abortion spontaneous	199.92	12.65	169	29031	47026	63412796
Maternal exposure during pregnancy	197.89	12.65	359	28841	219703	63240119
Fluid retention	190.13	12.65	182	29018	59504	63400318
Premature delivery	176.78	12.65	131	29069	30150	63429672
Hyperhidrosis	169.94	12.65	228	28972	107608	63352214
Upper respiratory tract infection	156.88	12.65	191	29009	81856	63377966
Product adhesion issue	154.81	12.65	64	29136	4655	63455167
Meningioma	118.41	12.65	50	29150	3835	63455987
Gestational diabetes	114.04	12.65	62	29138	8334	63451488
Premature baby	104.06	12.65	82	29118	20653	63439169
Asthma	101.84	12.65	198	29002	127363	63332459
Erythema	101.36	12.65	239	28961	175512	63284310
Foetal death	101.10	12.65	63	29137	10917	63448905
Death	97.40	12.65	26	29174	374355	63085467
Vaginal haemorrhage	95.49	12.65	88	29112	27399	63432423
Headache	91.43	12.65	549	28651	632692	62827130
Postmenopausal haemorrhage	83.88	12.65	33	29167	2109	63457713
Pregnancy	80.70	12.65	92	29108	36744	63423078
Autoimmune dermatitis	78.48	12.65	17	29183	118	63459704
Oligohydramnios	78.19	12.65	44	29156	6322	63453500
Premature rupture of membranes	76.62	12.65	40	29160	4953	63454869
Hot flush	75.69	12.65	105	29095	51054	63408768
Butterfly rash	75.40	12.65	29	29171	1744	63458078
Maternal exposure before pregnancy	73.49	12.65	45	29155	7558	63452264
Systemic lupus erythematosus	70.89	12.65	7	29193	208911	63250911
Toxicity to various agents	70.56	12.65	14	29186	247236	63212586
Pre-eclampsia	68.33	12.65	46	29154	9087	63450735
Glossodynia	66.28	12.65	4	29196	178872	63280950
Off label use	66.03	12.65	532	28668	673930	62785892
Constipation	64.89	12.65	239	28961	224704	63235118
Placenta accreta	64.69	12.65	16	29184	210	63459612
Congenital absence of vertebra	63.60	12.65	12	29188	36	63459786
Synovitis	61.52	12.65	7	29193	186911	63272911
Wound	59.45	12.65	4	29196	163259	63296563
Back pain	58.88	12.65	259	28941	263886	63195936
Drug hypersensitivity	58.53	12.65	290	28910	310397	63149425
Congenital vesicoureteric reflux	55.87	12.65	10	29190	20	63459802
Ectopic pregnancy	55.59	12.65	26	29174	2541	63457281
Atrial septal defect	54.45	12.65	36	29164	6902	63452920
Acute kidney injury	53.77	12.65	27	29173	263388	63196434
Pneumonia	52.17	12.65	81	29119	456686	63003136
Normal newborn	50.71	12.65	37	29163	8304	63451518
Arthropathy	49.54	12.65	23	29177	234769	63225053
Vulvovaginal discomfort	48.16	12.65	23	29177	2355	63457467
Haemorrhage in pregnancy	46.38	12.65	21	29179	1904	63457918
Abortion threatened	45.92	12.65	15	29185	557	63459265
Preterm premature rupture of membranes	45.84	12.65	19	29181	1390	63458432
Ovarian enlargement	43.92	12.65	14	29186	480	63459342
Subdural hygroma	43.56	12.65	12	29188	245	63459577
Periorbital oedema	43.41	12.65	29	29171	5655	63454167
Pericarditis	43.10	12.65	5	29195	131574	63328248
Progesterone decreased	42.05	12.65	10	29190	110	63459712
Prescribed overdose	41.65	12.65	64	29136	34089	63425733
Small for dates baby	40.92	12.65	24	29176	3727	63456095
Hepatic enzyme increased	39.57	12.65	191	29009	202137	63257685
Intermenstrual bleeding	39.02	12.65	31	29169	7895	63451927
Hormone level abnormal	38.41	12.65	20	29180	2463	63457359
Completed suicide	38.03	12.65	10	29190	145663	63314159
Gastroschisis	37.66	12.65	12	29188	411	63459411
Adnexal torsion	36.83	12.65	12	29188	442	63459380
Abdominal discomfort	36.50	12.65	57	29143	320828	63138994
Foetal growth restriction	36.02	12.65	29	29171	7524	63452298
Blister	35.67	12.65	8	29192	129806	63330016
Head discomfort	35.46	12.65	37	29163	13378	63446444
Human herpesvirus 6 infection	35.13	12.65	20	29180	2937	63456885
Ventricular septal defect	35.04	12.65	23	29177	4355	63455467
Periodic limb movement disorder	34.62	12.65	10	29190	244	63459578
Single umbilical artery	34.31	12.65	10	29190	252	63459570
Uterine haemorrhage	34.23	12.65	22	29178	4019	63455803
Hypersensitivity	34.17	12.65	241	28959	292444	63167378
Blood oestrogen decreased	34.09	12.65	10	29190	258	63459564
Photosensitivity reaction	33.77	12.65	38	29162	14956	63444866
HELLP syndrome	33.70	12.65	14	29186	1030	63458792
Abortion missed	32.92	12.65	16	29184	1703	63458119
Rheumatoid arthritis	32.60	12.65	214	28986	253605	63206217
Breast hyperplasia	32.59	12.65	10	29190	302	63459520
Endometrial stromal sarcoma	32.06	12.65	6	29194	17	63459805
Ovarian haemorrhage	31.80	12.65	10	29190	328	63459494
Suicidal behaviour	31.76	12.65	18	29182	2621	63457201
Product use issue	31.46	12.65	191	29009	220329	63239493
Caesarean section	31.45	12.65	39	29161	16993	63442829
Neutropenia	31.33	12.65	21	29179	174984	63284838
Ophthalmic vein thrombosis	31.26	12.65	9	29191	217	63459605
Swelling	31.22	12.65	49	29151	275329	63184493
Ascites	30.97	12.65	62	29138	40666	63419156
Confusional state	30.86	12.65	38	29162	236342	63223480
Product odour abnormal	30.79	12.65	14	29186	1282	63458540
Sepsis	30.76	12.65	16	29184	153107	63306715
General physical health deterioration	30.02	12.65	29	29171	201373	63258449
Psoriasis	29.88	12.65	98	29102	86859	63372963
Therapeutic product effect decreased	29.76	12.65	27	29173	193160	63266662
Retroplacental haematoma	29.39	12.65	8	29192	156	63459666
Decreased appetite	29.10	12.65	44	29156	251008	63208814
Twin pregnancy	28.91	12.65	13	29187	1160	63458662
Breast tenderness	28.20	12.65	16	29184	2334	63457488
Anaemia	28.08	12.65	58	29142	293372	63166450
Tinnitus	28.01	12.65	55	29145	35573	63424249
Product quality issue	27.76	12.65	55	29145	35810	63424012
Retained placenta or membranes	27.50	12.65	9	29191	336	63459486
Ovarian cyst	27.05	12.65	35	29165	15910	63443912
Cardiac arrest	26.88	12.65	5	29195	92540	63367282
Cyanosis neonatal	26.00	12.65	9	29191	400	63459422
Decidual cast	24.50	12.65	4	29196	3	63459819
Peripheral swelling	24.24	12.65	54	29146	265888	63193934
Patent ductus arteriosus	23.92	12.65	18	29182	4232	63455590
Hippocampal sclerosis	23.58	12.65	6	29194	89	63459733
Pelvic infection	22.83	12.65	8	29192	369	63459453
Application site pruritus	22.71	12.65	17	29183	3967	63455855
Talipes	22.67	12.65	12	29188	1528	63458294
Anxiety	22.43	12.65	174	29026	217367	63242455
Complication of pregnancy	22.35	12.65	9	29191	611	63459211
Menopausal symptoms	22.35	12.65	14	29186	2447	63457375
Folliculitis	22.22	12.65	3	29197	70314	63389508
Lower respiratory tract infection	22.21	12.65	17	29183	132290	63327532
Hypotonia neonatal	22.08	12.65	11	29189	1235	63458587
Vaginal discharge	21.90	12.65	24	29176	9174	63450648
Application site erythema	21.87	12.65	18	29182	4817	63455005
Product use in unapproved indication	21.77	12.65	149	29051	178931	63280891
Subchorionic haematoma	21.67	12.65	6	29194	125	63459697
Vomiting	21.48	12.65	160	29040	559457	62900365
Drug abuse	20.88	12.65	4	29196	72514	63387308
Mediastinal effusion	20.86	12.65	5	29195	57	63459765
Malignant neoplasm progression	20.75	12.65	6	29194	82115	63377707
Stomatitis	20.63	12.65	20	29180	138705	63321117
Nerve compression	20.41	12.65	23	29177	9064	63450758
Congenital umbilical hernia	20.33	12.65	7	29193	306	63459516
Carnitine deficiency	20.19	12.65	6	29194	162	63459660
Cardiac failure	19.94	12.65	8	29192	89134	63370688
Hypotension	19.79	12.65	62	29138	272542	63187280
Infection	19.70	12.65	48	29152	229125	63230697
Application site rash	19.69	12.65	13	29187	2485	63457337
Cholestasis of pregnancy	19.33	12.65	10	29190	1215	63458607
Wheezing	19.18	12.65	10	29190	95585	63364237
Hydrops foetalis	19.11	12.65	8	29192	600	63459222
Irritable bowel syndrome	19.10	12.65	7	29193	82405	63377417
Disease progression	19.08	12.65	17	29183	122741	63337081
Tubo-ovarian abscess	19.06	12.65	7	29193	370	63459452
Ovarian abscess	18.93	12.65	6	29194	202	63459620
Renal failure	18.64	12.65	16	29184	117636	63342186
Oestradiol increased	18.64	12.65	5	29195	92	63459730
Gastrointestinal haemorrhage	18.63	12.65	7	29193	81169	63378653
Temporal lobe epilepsy	18.47	12.65	7	29193	404	63459418
Haemoglobin decreased	18.34	12.65	24	29176	145461	63314361
Eosinophilic pneumonia acute	18.23	12.65	7	29193	419	63459403
Renal impairment	18.09	12.65	9	29191	88346	63371476
Cardiac failure congestive	18.06	12.65	10	29190	92423	63367399
Muscle injury	18.00	12.65	4	29196	65341	63394481
Hypogonadism	17.89	12.65	5	29195	108	63459714
Fallopian tube disorder	17.74	12.65	7	29193	451	63459371
Febrile neutropenia	17.70	12.65	17	29183	118432	63341390
Low birth weight baby	17.67	12.65	19	29181	7110	63452712
Dyspnoea	17.66	12.65	207	28993	661106	62798716
Postpartum haemorrhage	17.31	12.65	11	29189	1970	63457852
Therapeutic response unexpected	17.29	12.65	31	29169	18728	63441094
Turner's syndrome	17.12	12.65	5	29195	127	63459695
Abdominal pain lower	17.07	12.65	37	29163	25641	63434181
Selective eating disorder	16.86	12.65	11	29189	2061	63457761
Diarrhoea	16.84	12.65	230	28970	715136	62744686
Breast enlargement	16.62	12.65	10	29190	1626	63458196
Feeling abnormal	16.59	12.65	121	29079	148271	63311551
Neonatal asphyxia	16.45	12.65	6	29194	311	63459511
Ultrasound liver abnormal	16.35	12.65	4	29196	50	63459772
Mobility decreased	16.30	12.65	19	29181	121140	63338682
Endometrial hyperplasia	16.28	12.65	8	29192	872	63458950
Enlarged clitoris	16.23	12.65	5	29195	153	63459669
Biochemical pregnancy	16.16	12.65	3	29197	8	63459814
COVID-19	16.13	12.65	98	29102	113005	63346817
Application site irritation	16.00	12.65	10	29190	1740	63458082
Overdose	15.96	12.65	99	29101	114979	63344843
Palatal polyp	15.90	12.65	3	29197	9	63459813
Platelet count decreased	15.85	12.65	18	29182	116104	63343718
Drug exposure before pregnancy	15.83	12.65	8	29192	926	63458896
Opisthotonus	15.77	12.65	6	29194	350	63459472
Primary hypogonadism	15.62	12.65	5	29195	174	63459648
Premature separation of placenta	15.44	12.65	10	29190	1851	63457971
Injection site pain	15.17	12.65	107	29093	129693	63330129
Chronic obstructive pulmonary disease	15.08	12.65	5	29195	62681	63397141
Incorrect dose administered	15.02	12.65	61	29139	59907	63399915
Impaired healing	15.00	12.65	15	29185	102527	63357295
Fall	14.63	12.65	113	29087	392221	63067601
Product taste abnormal	14.48	12.65	10	29190	2057	63457765
Retinal vein occlusion	14.16	12.65	10	29190	2133	63457689
Heterotopic pregnancy	14.09	12.65	3	29197	19	63459803
Arterial intramural haematoma	14.09	12.65	3	29197	19	63459803
Cardio-respiratory arrest	14.05	12.65	5	29195	59954	63399868
Binge eating	14.01	12.65	6	29194	476	63459346
Pulmonary oedema	13.88	12.65	4	29196	54869	63404953
Anti-Muellerian hormone level decreased	13.75	12.65	4	29196	100	63459722
Application site urticaria	13.73	12.65	5	29195	258	63459564
Chorioretinopathy	13.67	12.65	7	29193	832	63458990
Respiratory disorder neonatal	13.67	12.65	8	29192	1237	63458585
Endometrial cancer stage I	13.66	12.65	5	29195	262	63459560
Product physical issue	13.64	12.65	14	29186	4966	63454856
Dehydration	13.60	12.65	38	29162	173316	63286506
Foetal hypokinesia	13.57	12.65	6	29194	514	63459308
Amniotic cavity infection	13.56	12.65	8	29192	1255	63458567
Blood oestrogen increased	13.46	12.65	4	29196	108	63459714
Keratoconus	13.37	12.65	3	29197	25	63459797
Lung disorder	13.27	12.65	6	29194	62255	63397567
Pancytopenia	13.26	12.65	15	29185	96918	63362904
Feeling hot	13.23	12.65	52	29148	50302	63409520
Oesophageal atresia	13.20	12.65	6	29194	549	63459273
Abortion early	13.16	12.65	3	29197	27	63459795
Drug intolerance	12.91	12.65	86	29114	308575	63151247
Pyogenic granuloma	12.87	12.65	5	29195	309	63459513
Liver tenderness	12.81	12.65	4	29196	128	63459694
Bradycardia	12.81	12.65	9	29191	73218	63386604
Abortion	12.80	12.65	10	29190	2486	63457336
Live birth	12.77	12.65	33	29167	25597	63434225
Malaise	12.76	12.65	126	29074	415828	63043994
Musculoskeletal stiffness	12.68	12.65	43	29157	184575	63275247

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Foetal exposure during pregnancy	701.50	85.14	173	933	37928	34917897
Premature baby	362.17	85.14	90	1016	19543	34936282
Atrial septal defect	151.22	85.14	37	1069	7355	34948470
Low birth weight baby	133.79	85.14	34	1072	7871	34947954
Hypospadias	107.59	85.14	24	1082	3177	34952648
Congenital hydronephrosis	101.95	85.14	18	1088	715	34955110
Human herpesvirus 6 infection	88.86	85.14	19	1087	2062	34953763

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Ovarian hyperstimulation syndrome	1015.01	14.18	228	21815	3343	79719002
Temperature regulation disorder	545.18	14.18	153	21890	5700	79716645
Food allergy	464.34	14.18	156	21887	10668	79711677
Coeliac disease	453.15	14.18	155	21888	11196	79711149
Immunodeficiency	361.61	14.18	157	21886	21611	79700734
Exposure during pregnancy	322.40	14.18	248	21795	100884	79621461
Bursitis	303.91	14.18	163	21880	35681	79686664
Maternal exposure during pregnancy	257.65	14.18	248	21795	136290	79586055
Rash erythematous	246.22	14.18	169	21874	57600	79664745
Fluid retention	224.09	14.18	172	21871	69637	79652708
Premature delivery	188.49	14.18	103	21940	23364	79698981
Upper respiratory tract infection	178.28	14.18	169	21874	90999	79631346
Hyperhidrosis	155.17	14.18	200	21843	151292	79571053
Abortion spontaneous	153.99	14.18	98	21945	29409	79692936
Premature labour	144.13	14.18	62	21981	8328	79714017
Asthma	139.34	14.18	179	21864	134916	79587429
Headache	130.20	14.18	436	21607	653336	79069009
Gestational diabetes	123.08	14.18	51	21992	6242	79716103
Erythema	110.60	14.18	211	21832	223079	79499266
Meningioma	108.97	14.18	42	22001	4256	79718089
Foetal death	101.73	14.18	48	21995	7996	79714349
Rheumatoid arthritis	100.77	14.18	195	21848	208275	79514070
Hepatic enzyme increased	98.44	14.18	179	21864	182431	79539914
Death	97.95	14.18	19	22024	566495	79155850
Butterfly rash	91.11	14.18	29	22014	1667	79720678
Back pain	90.10	14.18	234	21809	303946	79418399
Drug hypersensitivity	88.58	14.18	230	21813	298686	79423659
Premature rupture of membranes	86.47	14.18	35	22008	4034	79718311
Pre-eclampsia	85.94	14.18	41	22002	7000	79715345
Acute kidney injury	82.55	14.18	21	22022	519383	79202962
Vaginal haemorrhage	81.65	14.18	59	21984	21758	79700587
Maternal exposure before pregnancy	80.68	14.18	34	22009	4339	79718006
Autoimmune dermatitis	77.82	14.18	16	22027	149	79722196
Toxicity to various agents	77.49	14.18	12	22031	421528	79300817
Constipation	75.97	14.18	210	21833	282840	79439505
Hypersensitivity	73.81	14.18	198	21845	262041	79460304
Placenta accreta	73.74	14.18	16	22027	197	79722148
Normal newborn	70.86	14.18	36	22007	7036	79715309
Product adhesion issue	67.04	14.18	26	22017	2678	79719667
Haemorrhage in pregnancy	59.10	14.18	20	22023	1394	79720951
Keratoconus	57.86	14.18	12	22031	117	79722228
Ovarian enlargement	55.05	14.18	14	22029	354	79721991
Prescribed overdose	51.81	14.18	58	21985	37825	79684520
Abortion threatened	48.31	14.18	13	22030	412	79721933
Off label use	47.51	14.18	419	21624	906796	78815549
Pneumonia	46.69	14.18	69	21974	660177	79062168
Periorbital oedema	46.55	14.18	29	22014	8373	79713972
Hot flush	46.27	14.18	66	21977	54811	79667534
Uterine haemorrhage	45.13	14.18	20	22023	2883	79719462
Head discomfort	44.87	14.18	35	22008	14467	79707878
HELLP syndrome	44.20	14.18	14	22029	792	79721553
Ectopic pregnancy	44.07	14.18	17	22026	1726	79720619
Contraindicated product administered	41.32	14.18	116	21927	157422	79564923
Product use issue	40.64	14.18	139	21904	209683	79512662
Fatigue	40.48	14.18	413	21630	929314	78793031
Vulvovaginal discomfort	39.71	14.18	16	22027	1822	79720523
Breast hyperplasia	39.23	14.18	9	22034	145	79722200
Completed suicide	38.85	14.18	10	22033	245757	79476588
Postmenopausal haemorrhage	38.75	14.18	15	22028	1537	79720808
Neutropenia	37.96	14.18	16	22027	287694	79434651
Pain	37.76	14.18	327	21716	703475	79018870
Ovarian haemorrhage	37.49	14.18	10	22033	306	79722039
Photosensitivity reaction	37.17	14.18	37	22006	21090	79701255
Cardiac arrest	36.33	14.18	3	22040	172093	79550252
Adnexal torsion	35.59	14.18	10	22033	373	79721972
Ophthalmic vein thrombosis	35.26	14.18	9	22034	231	79722114
Pregnancy	34.82	14.18	40	22003	26811	79695534
Twin pregnancy	34.82	14.18	12	22031	884	79721461
Psoriasis	34.05	14.18	76	21967	89511	79632834
Caesarean section	33.99	14.18	28	22015	12507	79709838
Suicidal behaviour	33.91	14.18	17	22026	3230	79719115
Drug abuse	33.89	14.18	3	22040	162688	79559657
Intermenstrual bleeding	31.82	14.18	20	22023	5864	79716481
Sepsis	30.99	14.18	18	22025	269410	79452935
Anaemia	30.92	14.18	47	21996	444968	79277377
Synovitis	30.81	14.18	3	22040	150731	79571614
Preterm premature rupture of membranes	30.71	14.18	12	22031	1261	79721084
Retroplacental haematoma	29.94	14.18	7	22036	123	79722222
Hypotension	29.17	14.18	48	21995	440269	79282076
Confusional state	29.12	14.18	27	22016	317970	79404375
Endometrial stromal sarcoma	29.04	14.18	5	22038	15	79722330
Menopausal symptoms	28.84	14.18	13	22030	1950	79720395
Hormone level abnormal	28.59	14.18	13	22030	1989	79720356
Oligohydramnios	27.45	14.18	15	22028	3397	79718948
Tinnitus	27.13	14.18	46	21997	44287	79678058
Renal failure	26.78	14.18	11	22032	200957	79521388
Pelvic infection	26.69	14.18	8	22035	376	79721969
Ovarian abscess	26.68	14.18	6	22037	88	79722257
Product odour abnormal	26.64	14.18	11	22032	1333	79721012
Decidual cast	26.54	14.18	4	22039	3	79722342
Decreased appetite	25.93	14.18	34	22009	342384	79379961
Oestradiol increased	25.91	14.18	6	22037	101	79722244
Febrile neutropenia	25.76	14.18	16	22027	230983	79491362
Ovarian cyst	25.73	14.18	24	22019	12631	79709714
Progesterone decreased	25.34	14.18	5	22038	37	79722308
Foetal growth restriction	24.83	14.18	12	22031	2107	79720238
Foetal exposure during pregnancy	24.78	14.18	17	22026	5773	79716572
Retained placenta or membranes	24.71	14.18	7	22036	269	79722076
Ascites	24.24	14.18	60	21983	75502	79646843
Abortion missed	23.75	14.18	10	22033	1273	79721072
Blood oestrogen decreased	23.62	14.18	6	22037	151	79722194
Gastrointestinal haemorrhage	23.35	14.18	6	22037	147713	79574632
Mediastinal effusion	23.24	14.18	5	22038	59	79722286
Tubo-ovarian abscess	23.21	14.18	7	22036	336	79722009
Cardiac failure	23.16	14.18	7	22036	154835	79567510
Cholestasis of pregnancy	22.69	14.18	9	22034	984	79721361
Complication of pregnancy	22.48	14.18	7	22036	374	79721971
Bradycardia	22.42	14.18	5	22038	135552	79586793
Swelling face	22.26	14.18	56	21987	71156	79651189
General physical health deterioration	22.22	14.18	26	22017	275212	79447133
Abdominal pain lower	22.18	14.18	35	22008	31747	79690598
Renal impairment	22.08	14.18	8	22035	157775	79564570
Hypotonia neonatal	21.94	14.18	5	22038	78	79722267
Fallopian tube disorder	21.89	14.18	7	22036	408	79721937
Nerve compression	21.69	14.18	19	22024	9220	79713125
Postpartum haemorrhage	21.66	14.18	10	22033	1585	79720760
Porphyria non-acute	21.44	14.18	8	22035	741	79721604
Systemic lupus erythematosus	21.01	14.18	4	22039	121145	79601200
Amniotic cavity infection	20.67	14.18	8	22035	819	79721526
Malignant neoplasm progression	20.60	14.18	6	22037	135984	79586361
Carnitine deficiency	20.16	14.18	6	22037	275	79722070
Injection site pain	20.06	14.18	80	21963	129758	79592587
Hirsutism	19.82	14.18	9	22034	1373	79720972
Nephrocalcinosis	19.10	14.18	9	22034	1493	79720852
Breast enlargement	18.62	14.18	9	22034	1580	79720765
Platelet count decreased	18.44	14.18	16	22027	194648	79527697
Breast tenderness	18.32	14.18	10	22033	2258	79720087
Placental insufficiency	18.31	14.18	8	22035	1115	79721230
Cardio-respiratory arrest	17.95	14.18	4	22039	108506	79613839
Primary hypogonadism	17.91	14.18	5	22038	182	79722163
Haemoglobin decreased	17.91	14.18	21	22022	222098	79500247
Feeling hot	17.66	14.18	46	21997	59688	79662657
COVID-19	17.46	14.18	88	21955	157586	79564759
Congenital hydronephrosis	17.43	14.18	3	22040	9	79722336
Cardiac failure congestive	17.10	14.18	9	22034	142393	79579952
Respiratory failure	16.97	14.18	15	22028	180896	79541449
Blister	16.81	14.18	6	22037	119470	79602875
Glossodynia	16.72	14.18	4	22039	103333	79619012
Binge eating	16.66	14.18	6	22037	503	79721842
Arthropathy	16.24	14.18	15	22028	177096	79545249
Ovarian cyst ruptured	16.13	14.18	7	22036	959	79721386
Failed induction of labour	15.83	14.18	5	22038	280	79722065
Anti-Muellerian hormone level decreased	15.77	14.18	4	22039	100	79722245
Heterotopic pregnancy	15.61	14.18	3	22040	19	79722326
Product taste abnormal	15.60	14.18	9	22034	2262	79720083
Dehydration	15.55	14.18	28	22015	248159	79474186
Endometrial hyperplasia	15.36	14.18	6	22037	630	79721715
Subchorionic haematoma	15.34	14.18	4	22039	112	79722233
Eosinophilic pneumonia acute	15.27	14.18	7	22036	1091	79721254
Pulmonary oedema	15.12	14.18	3	22040	88251	79634094
Heavy menstrual bleeding	15.10	14.18	19	22024	13992	79708353
Pericarditis	15.07	14.18	5	22038	104231	79618114
Depressed mood	15.02	14.18	38	22005	48442	79673903
Live birth	15	14.18	22	22021	18722	79703623
Genital haemorrhage	14.96	14.18	13	22030	6242	79716103
Vaginal discharge	14.88	14.18	14	22029	7449	79714896
Embedded device	14.81	14.18	10	22033	3309	79719036
Retinal vein occlusion	14.80	14.18	10	22033	3313	79719032
Erythema nodosum	14.67	14.18	12	22031	5305	79717040
Drug interaction	14.65	14.18	62	21981	415121	79307224
Hallucination	14.51	14.18	3	22040	85742	79636603
Chronic obstructive pulmonary disease	14.43	14.18	3	22040	85416	79636929
Product quality issue	14.26	14.18	30	22013	33910	79688435

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Human herpesvirus 6 infection	46.81	37.71	15	363	45	89369
Congestive cardiomyopathy	40.41	37.71	14	364	57	89357

Pharmacologic Action:

Source	Code	Description
ATC	G03DA04	GENITO URINARY SYSTEM AND SEX HORMONES SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM PROGESTOGENS Pregnen (4) derivatives
ATC	G03FA04	GENITO URINARY SYSTEM AND SEX HORMONES SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM PROGESTOGENS AND ESTROGENS IN COMBINATION Progestogens and estrogens, fixed combinations
FDA CS	M0017672	Progesterone
MeSH PA	D009465	Neuromuscular Agents
MeSH PA	D009466	Neuromuscular Blocking Agents
MeSH PA	D003473	Neuromuscular Nondepolarizing Agents
MeSH PA	D018373	Peripheral Nervous System Agents
MeSH PA	D006728	Hormones
MeSH PA	D011372	Progestins
FDA EPC	N0000175601	Progesterone
CHEBI has role	CHEBI:49323	contraceptive drugs
CHEBI has role	CHEBI:59826	progestins
CHEBI has role	CHEBI:70709	progesterone receptor agonists
CHEBI has role	CHEBI:75771	Mus musculus metabolites
CHEBI has role	CHEBI:77746	Homo sapiens metabolite

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Contraception	indication	13197004
Dysfunctional uterine bleeding	indication	19155002
Atrophic vaginitis	indication	52441000
Secondary physiologic amenorrhea	indication	86030004
Secondary malignant neoplasm of kidney	indication	94360002
Postmenopausal osteoporosis	indication	102447009
Endometriosis	indication	129103003
Menopausal flushing	indication	198436008
Endometrial carcinoma	indication	254878006	DOID:2871
Infertility Secondary to Progesterone Deficiency	indication
Amenorrhea Secondary to Ovarian Dysfunction	indication
Prevention of Premature Labor	indication
Endometrial Hyperplasia Prevention	indication
Corpus Luteum Insufficiency Syndrome	indication
Polycystic ovaries	off-label use	69878008
Menorrhagia	off-label use	386692008
Precocious puberty	off-label use	400179000
Endogenous Estrogen Production Test	off-label use
Female Hormonal Imbalance	off-label use
Hyperlipoproteinemia	contraindication	3744001	DOID:1168
Hypocalcemia	contraindication	5291005
Alcoholism	contraindication	7200002
Weight gain finding	contraindication	8943002
Impaired glucose tolerance	contraindication	9414007
Hypercholesterolemia	contraindication	13644009
Jaundice	contraindication	18165001
Myocardial infarction	contraindication	22298006	DOID:5844
Fibroadenosis of breast	contraindication	23260002	DOID:10352
Diplopia	contraindication	24982008
Retinal hemorrhage	contraindication	28998008
Ectopic pregnancy	contraindication	34801009	DOID:0060329
Depressive disorder	contraindication	35489007
Chloasma	contraindication	36209000
Migraine	contraindication	37796009	DOID:6364
Hypertensive disorder	contraindication	38341003	DOID:10763
Disorder of gallbladder	contraindication	39621005	DOID:0060262
Hypothyroidism	contraindication	40930008	DOID:1459
Mild pre-eclampsia	contraindication	41114007
Body fluid retention	contraindication	43498006
Thrombosis of retinal vein	contraindication	46085004
Humoral hypercalcemia of malignancy	contraindication	47709007
Chronic heart failure	contraindication	48447003
Dementia	contraindication	52448006
Hepatic porphyria	contraindication	55056006	DOID:3133
Systemic lupus erythematosus	contraindication	55464009	DOID:9074
Hyperlipidemia	contraindication	55822004	DOID:1168
Anorexia nervosa	contraindication	56882008	DOID:8689
Hepatic failure	contraindication	59927004
Cerebrovascular disease	contraindication	62914000	DOID:6713
Thrombophlebitis	contraindication	64156001	DOID:3875
Osteoporosis	contraindication	64859006	DOID:11476
Intermenstrual bleeding - irregular	contraindication	64996003
Diabetes mellitus	contraindication	73211009	DOID:9351
Hyperglycemia	contraindication	80394007	DOID:4195
Epilepsy	contraindication	84757009	DOID:1826
Breast lump	contraindication	89164003
Kidney disease	contraindication	90708001	DOID:557
Malignant neoplasm of liver	contraindication	93870000	DOID:3571
Uterine leiomyoma	contraindication	95315005	DOID:13223
Neoplasm of liver	contraindication	126851005	DOID:3571
Deep venous thrombosis	contraindication	128053003
Seizure disorder	contraindication	128613002
Incomplete miscarriage	contraindication	156072005
Bed-ridden	contraindication	160685001
Mammography abnormal	contraindication	168750009
Asthma	contraindication	195967001	DOID:2841
Cerebrovascular accident	contraindication	230690007
Pulmonary thromboembolism	contraindication	233935004
Thrombophilia	contraindication	234467004	DOID:2452
Disease of liver	contraindication	235856003	DOID:409
Chorea	contraindication	271700006
Pregnancy, function	contraindication	289908002
Hypertriglyceridemia	contraindication	302870006
Osteopenia	contraindication	312894000
Functional visual loss	contraindication	313165001
Malignant tumor of ovary	contraindication	363443007	DOID:2394
Thromboembolic disorder	contraindication	371039008
Cardiovascular event risk	contraindication	395112001
Disorder of coronary artery	contraindication	414024009
Obesity	contraindication	414916001	DOID:9970
Estrogen receptor positive tumor	contraindication	416053008
Porphyria	contraindication	418470004
Optic disc edema	contraindication	423341008	DOID:146
Family history of malignant neoplasm of breast	contraindication	429740004
Hypertensive urgency	contraindication	443482000
Carcinoma of female breast	contraindication	447782002
Smokes tobacco daily	contraindication	449868002
Predisposition to Thrombosis	contraindication

🐶 Veterinary Drug Use

Species	Use	Relation
Cattle	Estrus synchronization	Indication
Cattle	Induction of estrous cycles	Indication
Cattle	Synchronization of the return to estrus	Indication
Cattle	Advancement of first postpartum estrus	Indication
Cattle	Advancement of first pubertal estrus	Indication
Cattle	To increase rate of weight gain	Indication
Cattle	To improve feed efficiency	Indication
Sheep	Estrus induction	Indication

🐶 Veterinary products

Product	Applicant	Ingredients
Synovex C, Synovex S	Zoetis Inc.	2
Component E-C with Tylan, Component E-S with Tylan	Elanco US Inc.	3
EAZI-BREED CIDR Cattle Insert	Zoetis Inc.	1
EAZI-BREED CIDR Sheep Insert	Zoetis Inc.	1

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

Formulation strength	Trade name	Applicant	Application number	Approval date	Type	Dose form	Route	Patent number	Patent expiration date	Patent use
1.78GM	MILPROSA	FERRING PHARMS INC	N201110	April 29, 2020	DISCN	SYSTEM	VAGINAL	10548904	Feb. 3, 2029	METHOD OF SUPPORTING EMBRYO IMPLANTATION AND EARLY PREGNANCY BY SUPPLEMENTATION OF CORPUS LUTEAL FUNCTION AS PART OF AN ASSISTED REPRODUCTIVE TECHNOLOGY (ART) TREATMENT PROGRAM FOR INFERTILE WOMEN
1.78GM	MILPROSA	FERRING PHARMS INC	N201110	April 29, 2020	DISCN	SYSTEM	VAGINAL	8580293	Jan. 21, 2030	METHOD OF SUPPORTING EMBRYO IMPLANTATION AND EARLY PREGNANCY BY SUPPLEMENTATION OF CORPUS LUTEAL FUNCTION AS PART OF AN ASSISTED REPRODUCTIVE TECHNOLOGY (ART) TREATMENT PROGRAM FOR INFERTILE WOMEN
0.5MG;100MG	BIJUVA	MAYNE PHARMA	N210132	Dec. 28, 2021	DISCN	CAPSULE	ORAL	10206932	Nov. 21, 2032	TREATMENT OF MENOPAUSE SYMPTOMS, INCLUDING VASOMOTOR SYMPTOMS
0.5MG;100MG	BIJUVA	MAYNE PHARMA	N210132	Dec. 28, 2021	DISCN	CAPSULE	ORAL	10675288	Nov. 21, 2032	TREATMENT OF MENOPAUSE SYMPTOMS, INCLUDING VASOMOTOR SYMPTOMS
0.5MG;100MG	BIJUVA	MAYNE PHARMA	N210132	Dec. 28, 2021	DISCN	CAPSULE	ORAL	11033626	Nov. 21, 2032	TREATMENT OF MENOPAUSE SYMPTOMS, INCLUDING VASOMOTOR SYMPTOMS
0.5MG;100MG	BIJUVA	MAYNE PHARMA	N210132	Dec. 28, 2021	DISCN	CAPSULE	ORAL	8846648	Nov. 21, 2032	TREATMENT OF MENOPAUSE SYMPTOMS, INCLUDING VASOMOTOR SYMPTOMS
0.5MG;100MG	BIJUVA	MAYNE PHARMA	N210132	Dec. 28, 2021	DISCN	CAPSULE	ORAL	8846649	Nov. 21, 2032	TREATMENT OF MENOPAUSE SYMPTOMS, INCLUDING VASOMOTOR SYMPTOMS
0.5MG;100MG	BIJUVA	MAYNE PHARMA	N210132	Dec. 28, 2021	DISCN	CAPSULE	ORAL	8933059	Nov. 21, 2032	TREATMENT OF MENOPAUSE SYMPTOMS, INCLUDING VASOMOTOR SYMPTOMS
0.5MG;100MG	BIJUVA	MAYNE PHARMA	N210132	Dec. 28, 2021	DISCN	CAPSULE	ORAL	9114145	Nov. 21, 2032	TREATMENT OF MENOPAUSE SYMPTOMS, INCLUDING VASOMOTOR SYMPTOMS
0.5MG;100MG	BIJUVA	MAYNE PHARMA	N210132	Dec. 28, 2021	DISCN	CAPSULE	ORAL	9114146	Nov. 21, 2032	TREATMENT OF MENOPAUSE SYMPTOMS, INCLUDING VASOMOTOR SYMPTOMS
0.5MG;100MG	BIJUVA	MAYNE PHARMA	N210132	Dec. 28, 2021	DISCN	CAPSULE	ORAL	9301920	Nov. 21, 2032	TREATMENT OF MENOPAUSE SYMPTOMS, INCLUDING VASOMOTOR SYMPTOMS
1MG;100MG	BIJUVA	MAYNE PHARMA	N210132	Oct. 28, 2018	RX	CAPSULE	ORAL	10206932	Nov. 21, 2032	TREATMENT OF MENOPAUSE SYMPTOMS, INCLUDING VASOMOTOR SYMPTOMS
1MG;100MG	BIJUVA	MAYNE PHARMA	N210132	Oct. 28, 2018	RX	CAPSULE	ORAL	10675288	Nov. 21, 2032	TREATMENT OF MENOPAUSE SYMPTOMS, INCLUDING VASOMOTOR SYMPTOMS
1MG;100MG	BIJUVA	MAYNE PHARMA	N210132	Oct. 28, 2018	RX	CAPSULE	ORAL	10806740	Nov. 21, 2032	TREATMENT OF MENOPAUSE SYMPTOMS, INCLUDING VASOMOTOR SYMPTOMS
1MG;100MG	BIJUVA	MAYNE PHARMA	N210132	Oct. 28, 2018	RX	CAPSULE	ORAL	11033626	Nov. 21, 2032	TREATMENT OF MENOPAUSE SYMPTOMS, INCLUDING VASOMOTOR SYMPTOMS
1MG;100MG	BIJUVA	MAYNE PHARMA	N210132	Oct. 28, 2018	RX	CAPSULE	ORAL	11103513	Nov. 21, 2032	TREATMENT OF MENOPAUSE SYMPTOMS, INCLUDING VASOMOTOR SYMPTOMS
1MG;100MG	BIJUVA	MAYNE PHARMA	N210132	Oct. 28, 2018	RX	CAPSULE	ORAL	8846648	Nov. 21, 2032	TREATMENT OF MENOPAUSE SYMPTOMS, INCLUDING VASOMOTOR SYMPTOMS
1MG;100MG	BIJUVA	MAYNE PHARMA	N210132	Oct. 28, 2018	RX	CAPSULE	ORAL	8846649	Nov. 21, 2032	TREATMENT OF MENOPAUSE SYMPTOMS, INCLUDING VASOMOTOR SYMPTOMS
1MG;100MG	BIJUVA	MAYNE PHARMA	N210132	Oct. 28, 2018	RX	CAPSULE	ORAL	9006222	Nov. 21, 2032	TREATMENT OF MENOPAUSE SYMPTOMS, INCLUDING VASOMOTOR SYMPTOMS
1MG;100MG	BIJUVA	MAYNE PHARMA	N210132	Oct. 28, 2018	RX	CAPSULE	ORAL	9114145	Nov. 21, 2032	TREATMENT OF MENOPAUSE SYMPTOMS, INCLUDING VASOMOTOR SYMPTOMS
1MG;100MG	BIJUVA	MAYNE PHARMA	N210132	Oct. 28, 2018	RX	CAPSULE	ORAL	9114146	Nov. 21, 2032	TREATMENT OF MENOPAUSE SYMPTOMS, INCLUDING VASOMOTOR SYMPTOMS
1MG;100MG	BIJUVA	MAYNE PHARMA	N210132	Oct. 28, 2018	RX	CAPSULE	ORAL	9301920	Nov. 21, 2032	TREATMENT OF MENOPAUSE SYMPTOMS, INCLUDING VASOMOTOR SYMPTOMS

Orange Book exclusivity data (new drug applications)

Formulation strength	Trade name	Applicant	Application number	Approval date	Type	Dose form	Route	Exclusivity date	Description
1.78GM	MILPROSA	FERRING PHARMS INC	N201110	April 29, 2020	DISCN	SYSTEM	VAGINAL	April 29, 2023	NEW PRODUCT

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source	MoA source
Progesterone receptor	Nuclear hormone receptor	P06401	PRGR_HUMAN	AGONIST	ED50	9.88	WOMBAT-PK	CHEMBL
Sigma non-opioid intracellular receptor 1	Membrane receptor	Q99720	SGMR1_HUMAN		Ki	6.59	CHEMBL
Multidrug resistance protein 1	Transporter	P08183	MDR1_HUMAN		IC50	4.32	CHEMBL
Glucocorticoid receptor	Nuclear hormone receptor	P04150	GCR_HUMAN		Ki	7.52	CHEMBL
Mineralocorticoid receptor	Nuclear hormone receptor	P08235	MCR_HUMAN		EC50	11	WOMBAT-PK
Estrogen receptor	Nuclear hormone receptor	P03372	ESR1_HUMAN				WOMBAT-PK
Androgen receptor	Nuclear hormone receptor	P10275	ANDR_HUMAN		Ki	8.07	CHEMBL
Corticosteroid-binding globulin	Secreted	P08185	CBG_HUMAN		Ki	7.38	CHEMBL
Sex hormone-binding globulin	Secreted	P04278	SHBG_HUMAN		Kd	6.94	CHEMBL
Sterol O-acyltransferase 1	Enzyme	P35610	SOAT1_HUMAN		IC50	4.77	CHEMBL
Fatty acid-binding protein, intestinal	Cytosolic other	P12104	FABPI_HUMAN		Ki	4.70	CHEMBL
Cation channel sperm-associated protein 1	Ion channel	Q8NEC5	CTSR1_HUMAN	ACTIVATOR	EC50	8.11	IUPHAR
Cation channel sperm-associated protein 2	Ion channel	Q96P56	CTSR2_HUMAN	ACTIVATOR	EC50	8.11	IUPHAR
Cation channel sperm-associated protein 3	Ion channel	Q86XQ3	CTSR3_HUMAN	ACTIVATOR	EC50	8.11	IUPHAR
Cation channel sperm-associated protein 4	Ion channel	Q7RTX7	CTSR4_HUMAN	ACTIVATOR	EC50	8.11	IUPHAR
Short transient receptor potential channel 5	Ion channel	Q9UL62	TRPC5_HUMAN	BLOCKER	IC50	5.30	IUPHAR
Sodium/nucleoside cotransporter 1	Transporter	O00337	S28A1_HUMAN		Ki	5.17	DRUG MATRIX
P2X purinoceptor 3	Ion channel	P56373	P2RX3_HUMAN		IC50	5.80	CHEMBL
Androgen receptor	Transcription factor		ANDR_RAT		IC50	5.81	CHEMBL
Fatty acid-binding protein, liver	Unclassified		FABPL_RAT		Ki	7.57	CHEMBL
Progesterone receptor	Transcription factor		Q690N0_BOVIN		Ki	8.44	DRUG MATRIX
Sigma non-opioid intracellular receptor 1	Membrane receptor		SGMR1_RAT		Kd	6.62	CHEMBL
Androgen receptor	Transcription factor		ANDR_MOUSE		IC50	7.43	CHEMBL
Progesterone receptor	Transcription factor		PRGR_RABIT		Ki	7.98	CHEMBL
C-8 sterol isomerase	Enzyme		ERG2_YEAST		Ki	5.35	CHEMBL
Sigma non-opioid intracellular receptor 1	Membrane other		SGMR1_CAVPO		Ki	6.18	CHEMBL
Steroid 5-alpha-reductase	Enzyme		S5A1_RAT S5A2_RAT		IC50	5.80	CHEMBL
Estrogen receptor	Transcription factor		ESR1_RAT ESR2_RAT		Kd	8.41	CHEMBL

External reference:

ID	Source
4017453	VUID
N0000145841	NUI
D00066	KEGG_DRUG
4017453	VANDF
C0033308	UMLSCUI
CHEBI:17026	CHEBI
STR	PDB_CHEM_ID
CHEMBL103	ChEMBL_ID
DB00396	DRUGBANK_ID
D011374	MESH_DESCRIPTOR_UI
C003549	MESH_SUPPLEMENTAL_RECORD_UI
5994	PUBCHEM_CID
2377	IUPHAR_LIGAND_ID
417	INN_ID
4G7DS2Q64Y	UNII
8727	RXNORM
2110	MMSL
53089	MMSL
5365	MMSL
d00550	MMSL
001290	NDDF
16683002	SNOMEDCT_US
50318003	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Crinone	HUMAN PRESCRIPTION DRUG LABEL	1	0023-6150	GEL	45 mg	VAGINAL	NDA	24 sections
Crinone	HUMAN PRESCRIPTION DRUG LABEL	1	0023-6150	GEL	45 mg	VAGINAL	NDA	24 sections
Crinone	HUMAN PRESCRIPTION DRUG LABEL	1	0023-6151	GEL	90 mg	VAGINAL	NDA	24 sections
Crinone	HUMAN PRESCRIPTION DRUG LABEL	1	0023-6151	GEL	90 mg	VAGINAL	NDA	24 sections
Progesterone	HUMAN PRESCRIPTION DRUG LABEL	1	0143-9725	INJECTION	50 mg	INTRAMUSCULAR	ANDA	13 sections
PROGESTERONE	HUMAN PRESCRIPTION DRUG LABEL	1	0591-3128	INJECTION, SOLUTION	50 mg	INTRAMUSCULAR	NDA	13 sections
PROGESTERONE	HUMAN PRESCRIPTION DRUG LABEL	1	0591-3128	INJECTION, SOLUTION	50 mg	INTRAMUSCULAR	NDA	13 sections
PROGESTERONE	Human Prescription Drug Label	1	10888-7135	CAPSULE	100 mg	ORAL	ANDA	21 sections
PROGESTERONE	Human Prescription Drug Label	1	10888-7136	CAPSULE	200 mg	ORAL	ANDA	21 sections
Progesterone	HUMAN PRESCRIPTION DRUG LABEL	1	16714-157	CAPSULE	100 mg	ORAL	ANDA	25 sections
Progesterone	HUMAN PRESCRIPTION DRUG LABEL	1	16714-158	CAPSULE	200 mg	ORAL	ANDA	25 sections
Progesterone	HUMAN PRESCRIPTION DRUG LABEL	1	17478-766	CAPSULE	100 mg	ORAL	ANDA	23 sections
Progesterone	HUMAN PRESCRIPTION DRUG LABEL	1	17478-767	CAPSULE	200 mg	ORAL	ANDA	23 sections
Progesterone	HUMAN PRESCRIPTION DRUG LABEL	1	43598-349	CAPSULE	100 mg	ORAL	ANDA	21 sections
Progesterone	HUMAN PRESCRIPTION DRUG LABEL	1	43598-349	CAPSULE	100 mg	ORAL	ANDA	21 sections
Progesterone	HUMAN PRESCRIPTION DRUG LABEL	1	43598-350	CAPSULE	200 mg	ORAL	ANDA	21 sections
Progesterone	HUMAN PRESCRIPTION DRUG LABEL	1	43598-350	CAPSULE	200 mg	ORAL	ANDA	21 sections
Progesterone	HUMAN PRESCRIPTION DRUG LABEL	1	50090-2527	CAPSULE	100 mg	ORAL	ANDA	23 sections
Progesterone	HUMAN PRESCRIPTION DRUG LABEL	1	50090-3240	CAPSULE	100 mg	ORAL	NDA	24 sections
Progesterone	HUMAN PRESCRIPTION DRUG LABEL	1	50090-4656	CAPSULE	100 mg	ORAL	ANDA	23 sections
Progesterone	Human Prescription Drug Label	1	50090-5928	CAPSULE	100 mg	ORAL	ANDA	22 sections
Progesterone	HUMAN PRESCRIPTION DRUG LABEL	1	50090-6475	CAPSULE	100 mg	ORAL	ANDA	24 sections
Bijuva	HUMAN PRESCRIPTION DRUG LABEL	2	50261-211	CAPSULE	100 mg	ORAL	NDA	33 sections
Bijuva	HUMAN PRESCRIPTION DRUG LABEL	2	50261-211	CAPSULE	100 mg	ORAL	NDA	33 sections
Bijuva	HUMAN PRESCRIPTION DRUG LABEL	2	50261-251	CAPSULE	100 mg	ORAL	NDA	33 sections
Progesterone	HUMAN PRESCRIPTION DRUG LABEL	1	53002-1760	CAPSULE	200 mg	ORAL	ANDA	23 sections
Prometrium	HUMAN PRESCRIPTION DRUG LABEL	1	54868-4230	CAPSULE	200 mg	ORAL	NDA	15 sections
Prometrium	HUMAN PRESCRIPTION DRUG LABEL	1	54868-4250	CAPSULE	100 mg	ORAL	NDA	15 sections
Prochieve	HUMAN PRESCRIPTION DRUG LABEL	1	55056-0406	GEL	45 mg	VAGINAL	NDA	24 sections
Crinone	HUMAN PRESCRIPTION DRUG LABEL	1	55056-0806	GEL	90 mg	VAGINAL	NDA	24 sections