prochlorperazine ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
2274 58-38-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • prochlorperazine mesylate
  • prochlorperazine
  • capazine
  • chlormeprazine
  • chlorperazine
  • meterazin
  • meterazine
  • proazine
  • prochlorpemazine
  • prochlorperazin
  • prochlorpromazine
  • prochlorperazine maleate
  • prochlorperazine edisylate
  • prochlorperazine dimaleate
  • prochlorperzine
A phenothiazine antipsychotic used principally in the treatment of NAUSEA; VOMITING; and VERTIGO. It is more likely than CHLORPROMAZINE to cause EXTRAPYRAMIDAL DISORDERS. (From Martindale, The Extra Pharmacopoeia, 30th ed, p612)
  • Molecular weight: 373.94
  • Formula: C20H24ClN3S
  • CLOGP: 4.58
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 0
  • TPSA: 9.72
  • ALOGS: -4.53
  • ROTB: 4
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.10 g O
50 mg P
0.10 g R

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Bocci G, Oprea TI, Benet LZ
S (Water solubility) 0.01 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 0.10 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 3.83 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 15 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 22 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 16 mL/min/kg Lombardo F, Berellini G, Obach RS
t_half (Half-life) 9 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 3.841 High 1
caco2-efflux Caco-2 efflux ratio (BA/AB) 1.074 High 1
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 16.788 10^-6 cm/s High 1
dh-clint Dog hepatocyte intrinsic clearance 34.754 uL/min/10^6 cells High 1
dppb Dog plasma protein binding (% unbound) 1.430 % High 1
fcs-ppb Fetal calf serum protein binding (% unbound) 2.980 % High 1
herg hERG pIC50 6.012 pIC50 High 1
hh-clint Human hepatocyte intrinsic clearance 10.889 uL/min/10^6 cells High 1
hlm-clint Human liver microsomal intrinsic clearance 45.709 uL/min/mg protein High 1
hppb Human plasma protein binding (% unbound) 1.060 % High 1
kinase-safety-class ACVR2A,ACVR2B,AKT1,AKT2,AKT3,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,CHEK1,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,ITK,JAK2,JAK3,MAP3K21,MAP3K7,MAPK10,MAPK12,MAPK7,MAPK9,MAPKAPK2,MET,MTOR,NTRK2,PDK2,PDK4,PDPK1,PIK3CB,PIM2,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK 48
kinase-selectivity-class AXL,EPHB4,PDK4,SIK2 4
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 1.432 High 1
mh-clint Mouse hepatocyte intrinsic clearance 137.088 High 1
mppb Mouse plasma protein binding (% unbound) 1.500 High 1
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 5.272 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 4.560 % High 1
rh-clint Rat hepatocyte intrinsic clearance 260.016 uL/min/10^6 cells High 1
rh-fuinc Rat hepatocyte fraction unbound in incubation 6.890 % High 1
rppb Rat plasma protein binding (% unbound) 1.320 % High 1
solubility-dd Solubility at pH 7.4 in DMSO 81.658 uM High 1

Approvals:

DateAgencyCompanyOrphan
Oct. 23, 1956 FDA GLAXOSMITHKLINE

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 1078.20 12.31 960 74872 157389 90395226
Nausea 354.09 12.31 1843 73989 1108473 89444142
Drug ineffective 329.38 12.31 407 75425 1383891 89168724
Gangrene 321.01 12.31 174 75658 12702 90539913
Dehydration 317.28 12.31 577 75255 193870 90358745
Arterial occlusive disease 312.54 12.31 169 75663 12277 90540338
Disease progression 310.94 12.31 507 75325 156108 90396507
Diarrhoea 303.00 12.31 1565 74267 937625 89614990
Carotid artery thrombosis 293.09 12.31 146 75686 8946 90543669
White blood cell count decreased 290.68 12.31 510 75322 166599 90386016
Neurologic neglect syndrome 282.04 12.31 141 75691 8706 90543909
Plasma cell myeloma 270.17 12.31 244 75588 40584 90512031
Synovitis 259.84 12.31 3 75829 329749 90222866
Adjustment disorder 256.35 12.31 136 75696 9506 90543109
Systemic lupus erythematosus 255.91 12.31 11 75821 361885 90190730
Death 247.31 12.31 891 74941 455660 90096955
Contraindicated product administered 243.42 12.31 5 75827 320134 90232481
Fatigue 243 12.31 1721 74111 1152302 89400313
Personality disorder 239.55 12.31 142 75690 12302 90540313
Arthropathy 237.97 12.31 18 75814 366224 90186391
Hemiplegia 219.79 12.31 148 75684 16012 90536603
Sensory loss 216.32 12.31 153 75679 17922 90534693
Platelet count decreased 215.13 12.31 400 75432 136569 90416046
Glossodynia 205.70 12.31 17 75815 321762 90230853
Motor dysfunction 203.31 12.31 151 75681 19079 90533536
Eating disorder 202.09 12.31 176 75656 27897 90524718
Skin haemorrhage 202.03 12.31 157 75675 21223 90531392
Sneezing 200.54 12.31 180 75652 29689 90522926
Vomiting 198.86 12.31 1231 74601 787062 89765553
Pericarditis 191.63 12.31 8 75824 270143 90282472
Affect lability 189.09 12.31 141 75691 17922 90534693
Coordination abnormal 176.56 12.31 145 75687 21211 90531404
Neutropenia 173.51 12.31 496 75336 224408 90328207
Sinus disorder 173.22 12.31 177 75655 34270 90518345
Sinus congestion 169.92 12.31 158 75674 27266 90525349
Therapeutic product effect decreased 168.52 12.31 18 75814 277553 90275062
Angina pectoris 164.69 12.31 183 75649 38977 90513638
Joint swelling 164.10 12.31 110 75722 503190 90049425
Hemiparesis 160.91 12.31 164 75668 31655 90520960
Constipation 159.03 12.31 556 75276 279839 90272776
Aphasia 158.00 12.31 187 75645 42625 90509990
Folliculitis 156.05 12.31 3 75829 204350 90348265
Skin exfoliation 154.22 12.31 234 75598 67679 90484936
Respiratory tract congestion 150.99 12.31 148 75684 27262 90525353
Asthenia 149.28 12.31 857 74975 532894 90019721
Malignant neoplasm progression 146.82 12.31 295 75537 106575 90446040
Psoriatic arthropathy 146.06 12.31 12 75820 228323 90324292
Infusion related reaction 145.63 12.31 84 75748 416696 90135919
Muscle spasticity 143.29 12.31 162 75670 35160 90517455
Wound 139.95 12.31 40 75792 302940 90249675
Condition aggravated 137.75 12.31 178 75654 595367 89957248
Dysphagia 136.77 12.31 295 75537 111983 90440632
Irritable bowel syndrome 135.22 12.31 10 75822 207438 90345177
Cataract 134.34 12.31 227 75605 71865 90480750
Neovascularisation 127.87 12.31 49 75783 1581 90551034
Hepatic enzyme increased 124.15 12.31 74 75758 360662 90191953
Lower respiratory tract infection 121.61 12.31 30 75802 250629 90301986
Fibromyalgia 121.11 12.31 15 75817 206254 90346361
Dysarthria 117.06 12.31 183 75649 54299 90498316
Therapeutic product effect incomplete 116.57 12.31 13 75819 193883 90358732
Mobility decreased 115.97 12.31 33 75799 250701 90301914
Drug intolerance 112.76 12.31 125 75707 447466 90105149
Type 2 diabetes mellitus 111.79 12.31 18 75814 203226 90349389
Neutrophil count decreased 109.85 12.31 207 75625 71325 90481290
Palpitations 108.72 12.31 305 75527 136423 90416192
Rhinorrhoea 108.63 12.31 233 75599 88083 90464532
Liver injury 106.25 12.31 10 75822 170557 90382058
Cystitis 106.11 12.31 196 75636 66522 90486093
Hospice care 102.12 12.31 76 75756 9628 90542987
Discomfort 102.04 12.31 51 75781 274284 90278331
Swelling 100.19 12.31 122 75710 418936 90133679
General physical health deterioration 99.93 12.31 90 75742 355025 90197590
Neuropathy peripheral 99.68 12.31 296 75536 136674 90415941
Neoplasm progression 96.36 12.31 150 75682 44336 90508279
Impaired healing 95.80 12.31 38 75794 234161 90318454
Ill-defined disorder 93.91 12.31 20 75812 184871 90367744
Full blood count decreased 93.90 12.31 120 75712 29569 90523046
Cytokine release syndrome 93.13 12.31 116 75716 27857 90524758
Joint range of motion decreased 92.96 12.31 5 75827 135638 90416977
Blood cholesterol increased 91.44 12.31 30 75802 207982 90344633
Cerebrovascular accident 88.97 12.31 266 75566 123267 90429348
Injury 87.57 12.31 28 75804 197321 90355294
Hypersensitivity 86.60 12.31 155 75677 454522 90098093
C-reactive protein abnormal 86.39 12.31 5 75827 127424 90425191
Akathisia 84.44 12.31 72 75760 11087 90541528
Blood magnesium decreased 83.21 12.31 83 75749 15610 90537005
Influenza like illness 82.79 12.31 198 75634 80413 90472202
Chest discomfort 82.35 12.31 279 75553 138086 90414529
Treatment failure 81.99 12.31 80 75752 303848 90248767
Weight increased 80.91 12.31 141 75691 417786 90134829
Red blood cell count decreased 79.85 12.31 141 75691 46210 90506405
Thrombosis 79.66 12.31 184 75648 73067 90479548
Musculoskeletal stiffness 78.90 12.31 79 75753 296453 90256162
C-reactive protein increased 78.26 12.31 27 75805 181362 90371253
Pancytopenia 74.67 12.31 246 75586 120017 90432598
Clostridium difficile infection 74.06 12.31 119 75713 36126 90516489
Influenza 73.56 12.31 270 75562 138994 90413621
Pleural effusion 73.07 12.31 233 75599 111758 90440857
Inflammation 72.98 12.31 29 75803 178563 90374052
Sleep disorder 71.85 12.31 38 75794 197992 90354623
Bacterial translocation 71.25 12.31 26 75806 730 90551885
Colitis 70.96 12.31 171 75661 69771 90482844
Maternal exposure during pregnancy 70.11 12.31 121 75711 359942 90192673
Carbohydrate antigen 125 increased 70.08 12.31 40 75792 3226 90549389
Decreased appetite 69.63 12.31 546 75286 375994 90176621
Bursitis 69.44 12.31 13 75819 131641 90420974
Paradoxical drug reaction 69.42 12.31 49 75783 5717 90546898
Pneumonia 69.37 12.31 827 75005 637232 89915383
Abdominal pain 65.73 12.31 560 75272 395161 90157454
Abdominal discomfort 65.59 12.31 194 75638 477134 90075481
Lip dry 65.38 12.31 5 75827 100950 90451665
Hypercholesterolaemia 65.33 12.31 5 75827 100887 90451728
Small intestinal obstruction 64.29 12.31 84 75748 21150 90531465
Prescribed overdose 62.76 12.31 5 75827 97620 90454995
Heart rate abnormal 61.13 12.31 46 75786 5925 90546690
Blood pressure increased 59.78 12.31 324 75508 196893 90355722
Sepsis 59.03 12.31 302 75530 179512 90373103
Toxicity to various agents 58.55 12.31 94 75738 287752 90264863
Pulmonary fibrosis 58.03 12.31 10 75822 107493 90445122
Oral pain 57.04 12.31 100 75732 32583 90520032
Asthma 56.24 12.31 72 75760 242088 90310527
Alopecia 55.91 12.31 219 75613 494852 90057763
Thrombocytopenia 55.43 12.31 331 75501 208394 90344221
Anaemia 54.27 12.31 491 75341 352311 90200304
Red blood cell sedimentation rate increased 53.74 12.31 4 75828 82591 90470024
Sciatica 53.49 12.31 10 75822 101372 90451243
Blister 53.06 12.31 82 75750 254916 90297699
Pneumonitis 52.54 12.31 115 75717 44055 90508560
Injection site pain 52.53 12.31 41 75791 173658 90378957
Failure to thrive 51.20 12.31 48 75784 8363 90544252
Wound infection 51.06 12.31 13 75819 106389 90446226
Drug abuse 50.81 12.31 5 75827 82342 90470273
Osteoarthritis 49.94 12.31 54 75778 195676 90356939
Lung disorder 49.76 12.31 32 75800 149851 90402764
Peripheral venous disease 49.49 12.31 6 75826 83915 90468700
Lymphadenitis 49.45 12.31 35 75797 4102 90548513
Haemoglobin decreased 49.02 12.31 266 75566 161690 90390925
Injection site reaction 48.75 12.31 9 75823 92071 90460544
Hip arthroplasty 48.71 12.31 4 75828 76204 90476411
Blood potassium decreased 47.67 12.31 116 75716 47611 90505004
Wheezing 47.24 12.31 79 75753 238001 90314614
Arthralgia 47.00 12.31 421 75411 778101 89774514
Palmar-plantar erythrodysaesthesia syndrome 46.66 12.31 84 75748 27939 90524676
Knee arthroplasty 46.55 12.31 7 75825 83175 90469440
Cough 46.23 12.31 492 75340 368470 90184145
Hypokalaemia 45.69 12.31 224 75608 130892 90421723
Hair colour changes 45.13 12.31 31 75801 3463 90549152
Back pain 45.04 12.31 434 75398 316741 90235874
Hyponatraemia 44.31 12.31 225 75607 133313 90419302
Autoimmune disorder 44.01 12.31 6 75826 76738 90475877
Pyrexia 43.51 12.31 785 75047 659700 89892915
Obesity 43.31 12.31 17 75815 105490 90447125
Klebsiella bacteraemia 43.26 12.31 27 75805 2565 90550050
Anxiety 42.57 12.31 421 75411 309351 90243264
Extrapyramidal disorder 42.53 12.31 60 75772 16243 90536372
Injection site erythema 41.89 12.31 15 75817 98487 90454128
Clonus 41.27 12.31 36 75796 5714 90546901
Coma 40.90 12.31 6 75826 72626 90479989
Anuria 40.85 12.31 56 75776 14762 90537853
Urticaria 40.15 12.31 131 75701 312603 90240012
Bacteraemia 39.91 12.31 69 75763 22231 90530384
Hypophagia 39.86 12.31 91 75741 35846 90516769
Lower limb fracture 39.62 12.31 11 75821 85002 90467613
Mucosal inflammation 38.58 12.31 121 75711 57504 90495111
Dysgeusia 37.65 12.31 113 75719 52447 90500168
Loss of personal independence in daily activities 37.63 12.31 35 75797 136070 90416545
Product use issue 37.17 12.31 146 75686 329773 90222842
Gait inability 36.70 12.31 41 75791 146415 90406200
Hypoxia 36.24 12.31 138 75694 72261 90480354
Deep vein thrombosis 35.92 12.31 162 75670 91458 90461157
Weight decreased 35.87 12.31 480 75352 379430 90173185
Epilepsy 35.85 12.31 12 75820 82194 90470421
Road traffic accident 35.69 12.31 23 75809 107603 90445012
Escherichia bacteraemia 35.43 12.31 33 75799 5702 90546913
Hair texture abnormal 34.97 12.31 30 75802 4657 90547958
Red cell distribution width increased 34.96 12.31 47 75785 12160 90540455
Night sweats 34.56 12.31 34 75798 128732 90423883
Embolism 34.28 12.31 41 75791 9440 90543175
Exposure during pregnancy 34.08 12.31 95 75737 238315 90314300
Blood creatine increased 33.57 12.31 35 75797 6932 90545683
Pregnancy 32.98 12.31 6 75826 62041 90490574
Chills 32.93 12.31 206 75626 131775 90420840
Lymphadenopathy 32.39 12.31 98 75734 45677 90506938
Product quality issue 32.20 12.31 13 75819 79312 90473303
Pulmonary embolism 31.90 12.31 203 75629 130617 90421998
Urinary tract infection 31.72 12.31 393 75439 305239 90247376
Serotonin syndrome 31.55 12.31 86 75746 37801 90514814
Liver disorder 31.43 12.31 33 75799 121236 90431379
Rectal cancer metastatic 31.20 12.31 11 75821 279 90552336
Suicide attempt 31.19 12.31 12 75820 75387 90477228
Alopecia areata 31.16 12.31 20 75812 1995 90550620
Product use in unapproved indication 31.14 12.31 160 75672 336076 90216539
Muscular weakness 30.91 12.31 286 75546 206380 90346235
Overdose 30.66 12.31 53 75779 157656 90394959
Osteoporosis 30.18 12.31 22 75810 96509 90456106
Mental status changes 30.08 12.31 94 75738 44585 90508030
Sinus tachycardia 29.22 12.31 70 75762 28443 90524172
Peripheral swelling 28.69 12.31 215 75617 412891 90139724
Haematocrit decreased 28.15 12.31 88 75744 41744 90510871
Oesophagitis 27.82 12.31 51 75781 17198 90535417
Intentional product use issue 27.72 12.31 91 75741 216801 90335814
Live birth 27.49 12.31 16 75816 79091 90473524
Off label use 27.39 12.31 708 75124 1101544 89451071
Therapeutic response decreased 27.34 12.31 21 75811 89708 90462907
Contusion 27.13 12.31 113 75719 251103 90301512
Hyperglycaemia 27.04 12.31 99 75733 50871 90501744
Streptococcal bacteraemia 26.98 12.31 19 75813 2208 90550407
Sleep disorder due to a general medical condition 26.87 12.31 3 75829 44735 90507880
Foetal heart rate abnormal 26.79 12.31 14 75818 948 90551667
Incorrect route of product administration 26.69 12.31 5 75827 50621 90501994
Bone pain 26.12 12.31 112 75720 61871 90490744
Gastric disorder 26.04 12.31 74 75758 33310 90519305
Medication error 25.56 12.31 20 75812 84632 90467983
Foetal exposure during pregnancy 25.52 12.31 3 75829 42972 90509643
Hypertension 25.15 12.31 253 75579 457279 90095336
Nail disorder 25.11 12.31 9 75823 59058 90493557
Hepatitis 25.02 12.31 14 75818 70725 90481890
Myelosuppression 24.85 12.31 7 75825 53584 90499031
Breast cancer metastatic 24.73 12.31 45 75787 15087 90537528
Musculoskeletal pain 24.64 12.31 68 75764 171183 90381432
Pain 24.19 12.31 642 75190 995699 89556916
Tumour marker increased 24.17 12.31 27 75805 5780 90546835
Neutropenic colitis 23.99 12.31 23 75809 4120 90548495
Blood bilirubin increased 23.54 12.31 85 75747 43385 90509230
Hepatic cirrhosis 23.13 12.31 12 75820 63241 90489374
Mucosal dryness 23.08 12.31 20 75812 3147 90549468
Bone erosion 22.67 12.31 8 75824 53013 90499602
Cancer pain 22.66 12.31 22 75810 4003 90548612
Injection site swelling 22.41 12.31 11 75821 59828 90492787
Dry skin 22.29 12.31 138 75694 87935 90464680
Joint dislocation 22.26 12.31 5 75827 44577 90508038
Muscle twitching 22.25 12.31 57 75775 24145 90528470
Lethargy 22.08 12.31 108 75724 63031 90489584
Lymphocyte count decreased 22.01 12.31 72 75760 34978 90517637
Extensor plantar response 21.66 12.31 14 75818 1413 90551202
Systemic inflammatory response syndrome 21.65 12.31 27 75805 6489 90546126
Intentional product misuse 21.46 12.31 26 75806 89578 90463037
Completed suicide 21.32 12.31 57 75775 145001 90407614
Laboratory test abnormal 21.12 12.31 80 75752 41774 90510841
Exostosis 21.09 12.31 9 75823 53125 90499490
Oedema 21.06 12.31 91 75741 200204 90352411
Immune effector cell-associated neurotoxicity syndrome 20.95 12.31 25 75807 5743 90546872
Oculogyric crisis 20.84 12.31 17 75815 2462 90550153
Foot deformity 20.82 12.31 12 75820 59639 90492976
Intentional overdose 20.65 12.31 29 75803 93805 90458810
Injection site bruising 20.54 12.31 9 75823 52298 90500317
Cholestasis of pregnancy 20.39 12.31 14 75818 1563 90551052
Appetite disorder 20.06 12.31 31 75801 9102 90543513
Clostridium difficile colitis 19.68 12.31 58 75774 26648 90525967
Dysphoria 19.65 12.31 25 75807 6129 90546486
Skin warm 19.62 12.31 28 75804 7659 90544956
Laryngitis 19.51 12.31 9 75823 50744 90501871
Joint stiffness 19.38 12.31 22 75810 78020 90474595
Therapy non-responder 19.14 12.31 55 75777 136649 90415966
Frequent bowel movements 19.10 12.31 12 75820 56923 90495692
Onychomycosis 19.05 12.31 4 75828 37372 90515243
Tremor 19.02 12.31 204 75628 152969 90399646
Madarosis 18.88 12.31 19 75813 3610 90549005
Prescribed underdose 18.79 12.31 21 75811 74998 90477617
Hypomagnesaemia 18.77 12.31 69 75763 35519 90517096
Injection site pruritus 18.55 12.31 11 75821 53823 90498792
Muscle contractions involuntary 18.38 12.31 17 75815 2911 90549704
Malaise 18.37 12.31 630 75202 585356 89967259
Hot flush 18.18 12.31 98 75734 59390 90493225
Thinking abnormal 18.06 12.31 34 75798 11698 90540917
Acquired cystic kidney disease 18.06 12.31 5 75827 55 90552560
Skull fracture 17.86 12.31 12 75820 1293 90551322
Arthritis 17.70 12.31 216 75616 167099 90385516
Blood pressure fluctuation 17.65 12.31 11 75821 52402 90500213
Breast cancer stage II 17.57 12.31 4 75828 35330 90517285
Monoclonal immunoglobulin increased 17.34 12.31 8 75824 413 90552202
Acute myeloid leukaemia 17.33 12.31 47 75785 20593 90532022
Autoimmune nephritis 17.32 12.31 8 75824 414 90552201
Enteritis 17.26 12.31 31 75801 10290 90542325
Neutropenic sepsis 16.98 12.31 43 75789 18087 90534528
Feeding disorder 16.89 12.31 42 75790 17470 90535145
Back injury 16.82 12.31 9 75823 46613 90506002
Tremor neonatal 16.73 12.31 6 75826 160 90552455
Oesophageal ulcer 16.67 12.31 21 75811 5098 90547517
Plasma cell myeloma recurrent 16.48 12.31 19 75813 4209 90548406
Performance status decreased 16.29 12.31 19 75813 4261 90548354
Ascites 16.22 12.31 81 75751 47659 90504956
Full blood count abnormal 16.09 12.31 67 75765 36530 90516085
Disability 16.02 12.31 7 75825 40738 90511877
Pancreatic carcinoma recurrent 15.95 12.31 5 75827 87 90552528
Acute kidney injury 15.79 12.31 365 75467 320022 90232593
Large intestinal obstruction 15.59 12.31 15 75817 2699 90549916
Morbid thoughts 15.55 12.31 9 75823 745 90551870
Haemorrhagic diathesis 15.41 12.31 21 75811 5503 90547112
Pancreatic carcinoma metastatic 15.26 12.31 14 75818 2374 90550241
Abdominal infection 15.25 12.31 14 75818 2376 90550239
Intestinal perforation 15.23 12.31 35 75797 13846 90538769
Human chorionic gonadotropin decreased 15.11 12.31 5 75827 104 90552511
Blood sodium decreased 14.95 12.31 54 75778 27559 90525056
Colon cancer metastatic 14.66 12.31 11 75821 1410 90551205
Lymph node pain 14.52 12.31 12 75820 1769 90550846
Oral mucosal blistering 14.51 12.31 23 75809 6901 90545714
Metastases to liver 14.48 12.31 55 75777 28752 90523863
Malignant pleural effusion 14.48 12.31 15 75817 2949 90549666
Dyssomnia 14.36 12.31 4 75828 45 90552570
Drug reaction with eosinophilia and systemic symptoms 14.36 12.31 9 75823 42749 90509866
Non-small cell lung cancer 14.31 12.31 18 75814 4363 90548252
Drug interaction 14.30 12.31 155 75677 276298 90276317
Breast cellulitis 13.97 12.31 8 75824 649 90551966
Blood alkaline phosphatase increased 13.88 12.31 78 75754 48001 90504614
Transposition of the great vessels 13.84 12.31 6 75826 267 90552348
Multiple sclerosis relapse 13.81 12.31 14 75818 52291 90500324
Sedation 13.77 12.31 12 75820 48159 90504456
Aspartate aminotransferase increased 13.68 12.31 139 75693 102798 90449817
Hypermagnesaemia 13.63 12.31 10 75822 1239 90551376
Paraneoplastic dermatomyositis 13.58 12.31 5 75827 144 90552471
Ovarian cancer recurrent 13.57 12.31 11 75821 1579 90551036
Neutrophil count abnormal 13.55 12.31 17 75815 4111 90548504
Hypertonia 13.49 12.31 19 75813 5136 90547479
Metastases to peritoneum 13.46 12.31 17 75815 4138 90548477
Malignant ascites 13.45 12.31 9 75823 963 90551652
Liver iron concentration abnormal 13.43 12.31 4 75828 58 90552557
Plasmacytoma 13.40 12.31 14 75818 2779 90549836
Fall 13.37 12.31 511 75321 481299 90071316
Arthritis infective 13.36 12.31 24 75808 7968 90544647
Lipase increased 13.29 12.31 29 75803 11082 90541533
Enterocolitis infectious 13.08 12.31 12 75820 2035 90550580
Atrial fibrillation 13.07 12.31 170 75662 133441 90419174
Herpes simplex reactivation 13.06 12.31 9 75823 1010 90551605
Ear infection 13.06 12.31 24 75808 69751 90482864
Cytopenia 12.95 12.31 38 75794 17411 90535204
Infection 12.94 12.31 219 75613 361875 90190740
Renal cancer metastatic 12.91 12.31 6 75826 315 90552300
Colitis ulcerative 12.89 12.31 19 75813 60247 90492368
Coronary artery disease 12.87 12.31 6 75826 33617 90518998
Accidental exposure to product 12.80 12.31 10 75822 42356 90510259
Parkinsonism 12.80 12.31 33 75799 14032 90538583
Depressed level of consciousness 12.78 12.31 26 75806 72758 90479857
Pubic pain 12.77 12.31 5 75827 171 90552444
Macular degeneration 12.74 12.31 8 75824 37962 90514653
Eosinophilia 12.73 12.31 4 75828 28529 90524086
Immature granulocyte count increased 12.64 12.31 7 75825 533 90552082
Walking aid user 12.59 12.31 7 75825 35499 90517116
Monocyte count decreased 12.45 12.31 13 75819 2578 90550037
Tenderness 12.45 12.31 50 75782 26818 90525797

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 1138.77 12.21 1166 42963 184537 42392669
Fatigue 262.94 12.21 1015 43114 434626 42142580
Plasma cell myeloma 212.35 12.21 254 43875 47324 42529882
Nausea 185.48 12.21 856 43273 395943 42181263
Dehydration 178.80 12.21 429 43700 141338 42435868
Death 174.79 12.21 952 43177 470233 42106973
Drug ineffective 140.65 12.21 276 43853 629921 41947285
Diarrhoea 139.52 12.21 883 43246 459966 42117240
Malignant neoplasm progression 128.00 12.21 320 43809 108080 42469126
Cytokine release syndrome 126.83 12.21 191 43938 44336 42532870
Decreased appetite 119.78 12.21 455 43674 192682 42384524
Vomiting 104.62 12.21 582 43547 289141 42288065
Pneumonia 100.40 12.21 763 43366 421386 42155820
Condition aggravated 91.87 12.21 81 44048 260673 42316533
Disease progression 89.42 12.21 339 43790 143317 42433889
Constipation 85.84 12.21 364 43765 161927 42415279
Drug interaction 82.51 12.21 93 44036 266906 42310300
Drug abuse 82.41 12.21 7 44122 104764 42472442
White blood cell count decreased 81.03 12.21 275 43854 110121 42467085
Hospice care 71.73 12.21 64 44065 8449 42568757
Toxicity to various agents 71.66 12.21 79 44050 229057 42348149
Neuropathy peripheral 71.49 12.21 250 43879 101603 42475603
Full blood count decreased 68.45 12.21 95 44034 20465 42556741
Platelet count decreased 57.09 12.21 289 43840 138292 42438914
Failure to thrive 56.97 12.21 59 44070 9363 42567843
Bacteraemia 54.35 12.21 95 44034 24945 42552261
Product use in unapproved indication 53.97 12.21 67 44062 184389 42392817
Therapeutic product effect incomplete 52.47 12.21 6 44123 70933 42506273
Asthenia 52.32 12.21 481 43648 280312 42296894
Immune effector cell-associated neurotoxicity syndrome 48.00 12.21 54 44075 9407 42567799
Meconium abnormal 47.95 12.21 12 44117 67 42577139
Neutropenia 47.43 12.21 361 43768 199070 42378136
Overdose 47.26 12.21 25 44104 105239 42471967
Rash 45.45 12.21 462 43667 276492 42300714
Completed suicide 44.66 12.21 22 44107 96443 42480763
Small intestinal obstruction 42.71 12.21 69 44060 16992 42560214
Neutrophil count decreased 42.18 12.21 153 43976 63262 42513944
Intentional product misuse 39.48 12.21 8 44121 61892 42515314
Back pain 39.09 12.21 266 43863 141510 42435696
Injection site pain 37.85 12.21 7 44122 57791 42519415
Sepsis 36.82 12.21 341 43788 198993 42378213
Intentional overdose 36.47 12.21 5 44124 51451 42525755
Coma 33.99 12.21 7 44122 53547 42523659
Hypophagia 33.25 12.21 81 44048 26875 42550331
Psoriasis 31.59 12.21 6 44123 48598 42528608
Suicide attempt 31.47 12.21 5 44124 46095 42531111
Necrotising enterocolitis neonatal 31.01 12.21 12 44117 319 42576887
Muscle spasms 30.98 12.21 173 43956 85871 42491335
Escherichia bacteraemia 30.69 12.21 32 44097 5117 42572089
Rhabdomyolysis 30.20 12.21 22 44107 77997 42499209
Neoplasm progression 28.45 12.21 80 44049 28920 42548286
Bradycardia 28.33 12.21 28 44101 85456 42491750
Streptococcal bacteraemia 28.11 12.21 23 44106 2699 42574507
Deep vein thrombosis 27.88 12.21 155 43974 76802 42500404
Cardiac failure 27.05 12.21 43 44086 106813 42470393
Weight decreased 26.38 12.21 330 43799 207618 42369588
Pancytopenia 26.20 12.21 210 43919 117533 42459673
C-reactive protein increased 25.83 12.21 17 44112 63543 42513663
Asthma 24.87 12.21 17 44112 62297 42514909
Haematochezia 24.61 12.21 15 44114 58421 42518785
General physical health deterioration 24.30 12.21 78 44051 151168 42426038
Myelosuppression 24.25 12.21 6 44123 40455 42536751
Laboratory test abnormal 24.14 12.21 65 44064 22913 42554293
Rheumatoid arthritis 24.10 12.21 7 44122 42433 42534773
Treatment failure 23.80 12.21 18 44111 62606 42514600
Colitis 23.43 12.21 103 44026 46469 42530737
Spinal cord compression 22.96 12.21 25 44104 4199 42573007
Ageusia 22.59 12.21 42 44087 11563 42565643
Oral pain 22.56 12.21 44 44085 12552 42564654
Taste disorder 22.50 12.21 39 44090 10168 42567038
Therapeutic response decreased 21.21 12.21 6 44123 37006 42540200
Enteritis 20.87 12.21 39 44090 10777 42566429
Dysgeusia 20.65 12.21 80 44049 34109 42543097
Drug reaction with eosinophilia and systemic symptoms 20.38 12.21 9 44120 42066 42535140
Hiccups 19.98 12.21 41 44088 12130 42565076
Fluid imbalance 19.87 12.21 9 44120 358 42576848
Cholestasis 19.46 12.21 5 44124 32874 42544332
Wrong technique in product usage process 19.31 12.21 10 44119 42625 42534581
Enterocolitis infectious 18.91 12.21 16 44113 1967 42575239
Inappropriate schedule of product administration 18.71 12.21 45 44084 95857 42481349
Hypometabolism 18.61 12.21 7 44122 172 42577034
Coronary artery disease 18.49 12.21 17 44112 53703 42523503
Cardiogenic shock 18.28 12.21 7 44122 35633 42541573
Drug dependence 18.06 12.21 4 44125 29090 42548116
Therapeutic product effect decreased 18.00 12.21 9 44120 39141 42538065
Neutrophil count abnormal 17.93 12.21 18 44111 2753 42574453
Pulmonary embolism 17.89 12.21 196 43933 119416 42457790
Blood potassium decreased 17.85 12.21 54 44075 20330 42556876
Adverse drug reaction 17.48 12.21 81 44048 37353 42539853
Cancer pain 17.48 12.21 20 44109 3547 42573659
Dystonia 17.47 12.21 40 44089 12750 42564456
Alpha haemolytic streptococcal infection 17.43 12.21 15 44114 1887 42575319
Laparotomy 17.41 12.21 8 44121 329 42576877
Pleural effusion 17.29 12.21 165 43964 97001 42480205
Pneumonitis 17.13 12.21 87 44042 41631 42535575
Gastrointestinal injury 17.12 12.21 12 44117 1117 42576089
Clostridium difficile infection 17.07 12.21 57 44072 22602 42554604
Hyponatraemia 16.93 12.21 170 43959 101292 42475914
Peripheral swelling 16.91 12.21 155 43974 90115 42487091
Mental status changes 16.72 12.21 87 44042 42028 42535178
Inferior vena caval occlusion 16.53 12.21 5 44124 61 42577145
Diaphragmatic rupture 16.52 12.21 4 44125 19 42577187
Atrial fibrillation 16.19 12.21 218 43911 139375 42437831
Abdominal pain 16.15 12.21 282 43847 190189 42387017
Hepatic cytolysis 16.05 12.21 4 44125 26840 42550366
Eosinophilia 16.00 12.21 7 44122 32892 42544314
Oesophagitis 15.88 12.21 43 44086 15204 42562002
Musculoskeletal stiffness 15.82 12.21 22 44107 57743 42519463
Mixed dementia 15.73 12.21 7 44122 267 42576939
Sedation 15.60 12.21 6 44123 30469 42546737
Urinary tract infection pseudomonal 15.43 12.21 12 44117 1309 42575897
Metabolic acidosis 14.97 12.21 19 44110 51839 42525367
Embolism 14.96 12.21 30 44099 8733 42568473
Angle closure glaucoma 14.89 12.21 11 44118 1111 42576095
Retching 14.84 12.21 28 44101 7793 42569413
Thrombosis 14.58 12.21 121 44008 68390 42508816
Rash pruritic 14.45 12.21 71 44058 33532 42543674
Psoriatic arthropathy 14.39 12.21 4 44125 24963 42552243
Drug ineffective for unapproved indication 14.30 12.21 16 44113 46147 42531059
Temperature intolerance 14.28 12.21 21 44108 4767 42572439
Stress 14.05 12.21 15 44114 44197 42533009
Aggression 14.02 12.21 15 44114 44148 42533058
Foetal exposure during pregnancy 14.01 12.21 17 44112 47294 42529912
Red blood cell count decreased 13.98 12.21 69 44060 32646 42544560
Starvation 13.90 12.21 8 44121 528 42576678
Wrist deformity 13.83 12.21 7 44122 357 42576849
Inflammation 13.82 12.21 9 44120 33838 42543368
Colitis ulcerative 13.66 12.21 5 44124 26170 42551036
Epilepsy 13.65 12.21 5 44124 26166 42551040
Loss of personal independence in daily activities 13.62 12.21 19 44110 49797 42527409
Stomatitis 13.59 12.21 94 44035 50235 42526971
Rectal haemorrhage 13.48 12.21 19 44110 49587 42527619
Systemic inflammatory response syndrome 13.46 12.21 26 44103 7364 42569842
Abdominal distension 13.35 12.21 123 44006 71612 42505594
Seizure 13.24 12.21 72 44057 120489 42456717
Psychotic disorder 13.00 12.21 7 44122 29201 42548005
Cholangitis 12.97 12.21 32 44097 10695 42566511
Contraindicated product administered 12.90 12.21 5 44124 25267 42551939
Anaemia of chronic disease 12.70 12.21 11 44118 1395 42575811
Tooth disorder 12.70 12.21 34 44095 11945 42565261
Plasma cell myeloma recurrent 12.69 12.21 22 44107 5735 42571471
Dysphagia 12.69 12.21 123 44006 72596 42504610
Erythema 12.49 12.21 64 44065 108729 42468477
Ventricular fibrillation 12.31 12.21 8 44121 30115 42547091
Accidental overdose 12.31 12.21 7 44122 28323 42548883
Bone pain 12.25 12.21 53 44076 23739 42553467

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 2323.80 11.67 2070 98080 314697 110174452
Dehydration 435.78 11.67 851 99299 278660 110210489
Nausea 394.42 11.67 2174 97976 1233516 109255633
Fatigue 381.79 11.67 2130 98020 1213828 109275321
Plasma cell myeloma 346.31 11.67 352 99798 62584 110426565
Drug ineffective 342.67 11.67 532 99618 1520008 108969141
Diarrhoea 334.95 11.67 1962 98188 1137543 109351606
Disease progression 328.04 11.67 699 99451 243335 110245814
White blood cell count decreased 286.54 11.67 638 99512 228752 110260397
Carotid artery thrombosis 285.44 11.67 150 100000 9488 110479661
Gangrene 282.16 11.67 179 99971 16162 110472987
Arterial occlusive disease 277.65 11.67 173 99977 15135 110474014
Neurologic neglect syndrome 276.20 11.67 145 100005 9153 110479996
Death 260.80 11.67 1286 98864 697583 109791566
Adjustment disorder 245.17 11.67 141 100009 10654 110478495
Personality disorder 232.63 11.67 145 100005 12692 110476457
Synovitis 232.27 11.67 3 100147 274089 110215060
Cytokine release syndrome 232.08 11.67 302 99848 70004 110419145
Vomiting 228.55 11.67 1507 98643 909168 109579981
Malignant neoplasm progression 215.06 11.67 483 99667 174084 110315065
Platelet count decreased 204.06 11.67 562 99588 229881 110259268
Sensory loss 196.86 11.67 160 99990 21297 110467852
Condition aggravated 193.14 11.67 229 99921 734607 109754542
Contraindicated product administered 190.38 11.67 8 100142 248259 110240890
Systemic lupus erythematosus 189.20 11.67 10 100140 254328 110234821
Eating disorder 188.97 11.67 183 99967 30675 110458474
Affect lability 183.82 11.67 145 100005 18492 110470657
Arthropathy 181.85 11.67 23 100127 287499 110201650
Skin haemorrhage 178.53 11.67 161 99989 24666 110464483
Hemiplegia 174.27 11.67 153 99997 22629 110466520
Sneezing 172.46 11.67 177 99973 31807 110457342
Motor dysfunction 169.09 11.67 155 99995 24251 110464898
Constipation 168.60 11.67 706 99444 357080 110132069
Pneumonia 168.09 11.67 1361 98789 875353 109613796
Coordination abnormal 166.62 11.67 156 99994 25072 110464077
Sinus disorder 163.72 11.67 174 99976 32554 110456595
Therapeutic product effect decreased 158.30 11.67 18 100132 244298 110244851
Neutropenia 158.02 11.67 715 99435 373905 110115244
Sinus congestion 157.82 11.67 165 99985 30294 110458855
Asthenia 149.35 11.67 1101 99049 687898 109801251
Therapeutic product effect incomplete 148.80 11.67 15 100135 223790 110265359
Respiratory tract congestion 143.75 11.67 158 99992 30699 110458450
Muscle spasticity 137.19 11.67 166 99984 35749 110453400
Aphasia 136.51 11.67 214 99936 58783 110430366
Psoriatic arthropathy 133.95 11.67 12 100138 196749 110292400
Folliculitis 133.39 11.67 4 100146 167649 110321500
Dysphagia 133.31 11.67 372 99778 153228 110335921
Pericarditis 130.42 11.67 21 100129 219093 110270056
Decreased appetite 129.68 11.67 805 99345 475041 110014108
Joint swelling 129.54 11.67 126 100024 442719 110046430
Neutrophil count decreased 128.57 11.67 316 99834 120625 110368524
Hospice care 122.91 11.67 97 100053 12376 110476773
Hemiparesis 121.24 11.67 173 99977 43730 110445419
Neovascularisation 121.09 11.67 49 100101 1688 110487461
Drug abuse 117.64 11.67 12 100138 177399 110311750
Glossodynia 116.04 11.67 29 100121 221975 110267174
Angina pectoris 116.03 11.67 205 99945 62090 110427059
Neoplasm progression 114.47 11.67 208 99942 64387 110424762
Sepsis 112.95 11.67 590 99560 326756 110162393
Toxicity to various agents 112.49 11.67 163 99987 480392 110008757
Failure to thrive 111.59 11.67 95 100055 13479 110475670
Skin exfoliation 110.64 11.67 245 99905 87406 110401743
Drug intolerance 110.60 11.67 123 100027 406389 110082760
Full blood count decreased 102.97 11.67 136 100014 31963 110457186
Small intestinal obstruction 102.59 11.67 136 100014 32077 110457072
Lower respiratory tract infection 102.29 11.67 46 100104 243060 110246089
Fibromyalgia 100.32 11.67 17 100133 170892 110318257
Cataract 100.13 11.67 222 99928 79263 110409886
General physical health deterioration 99.77 11.67 144 100006 425151 110063998
Irritable bowel syndrome 99.39 11.67 15 100135 164200 110324949
Cystitis 98.95 11.67 198 99952 65838 110423311
C-reactive protein increased 96.87 11.67 38 100112 217881 110271268
C-reactive protein abnormal 96.73 11.67 5 100145 129690 110359459
Wound 96.09 11.67 46 100104 234391 110254758
Hepatic enzyme increased 95.31 11.67 90 100060 320802 110168347
Colitis 94.92 11.67 254 99896 102069 110387080
Bacteraemia 94.25 11.67 151 99999 42239 110446910
Inflammation 90.45 11.67 31 100119 193207 110295942
Neuropathy peripheral 88.43 11.67 359 99791 178918 110310231
Pancytopenia 88.19 11.67 400 99750 209213 110279936
Joint range of motion decreased 86.92 11.67 6 100144 121826 110367323
Injury 85.49 11.67 27 100123 177238 110311911
Type 2 diabetes mellitus 85.46 11.67 27 100123 177205 110311944
Dysarthria 85.39 11.67 216 99934 83905 110405244
Hypersensitivity 85.06 11.67 147 100003 403851 110085298
Impaired healing 84.68 11.67 36 100114 196681 110292468
Asthma 84.43 11.67 62 100088 250229 110238920
Clostridium difficile infection 83.79 11.67 161 99989 51968 110437181
Discomfort 83.70 11.67 45 100105 214662 110274487
Palpitations 83.49 11.67 325 99825 158887 110330262
Musculoskeletal stiffness 81.32 11.67 80 100070 279742 110209407
Mobility decreased 81.14 11.67 58 100092 237364 110251785
Ill-defined disorder 80.98 11.67 21 100129 156832 110332317
Infusion related reaction 80.88 11.67 138 100012 381024 110108125
Weight increased 80.14 11.67 162 99988 419482 110069667
Liver injury 79.86 11.67 19 100131 150394 110338755
Blood magnesium decreased 78.95 11.67 94 100056 19902 110469247
Bursitis 78.32 11.67 12 100138 129906 110359243
Blood cholesterol increased 77.67 11.67 35 100115 184750 110304399
Swelling 77.35 11.67 124 100026 350917 110138232
Rhinorrhoea 75.98 11.67 235 99915 102431 110386718
Influenza like illness 75.56 11.67 213 99937 88199 110400950
Cerebrovascular accident 74.80 11.67 344 99806 180940 110308209
Bacterial translocation 73.81 11.67 33 100117 1459 110487690
Pleural effusion 73.16 11.67 337 99813 177372 110311777
Coma 73.11 11.67 10 100140 117859 110371290
Immune effector cell-associated neurotoxicity syndrome 72.88 11.67 78 100072 14704 110474445
Injection site pain 71.25 11.67 36 100114 177886 110311263
Abdominal pain 69.45 11.67 740 99410 512249 109976900
Lip dry 68.38 11.67 6 100144 100077 110389072
Treatment failure 67.84 11.67 91 100059 277143 110212006
Hypophagia 67.42 11.67 148 100002 52478 110436671
Drug interaction 66.66 11.67 231 99919 499952 109989197
Thrombosis 66.33 11.67 233 99917 108429 110380720
Oral pain 65.60 11.67 120 100030 37324 110451825
Product use in unapproved indication 65.60 11.67 198 99952 447179 110041970
Escherichia bacteraemia 65.48 11.67 62 100088 10102 110479047
Obesity 64.94 11.67 12 100138 113339 110375810
Red blood cell count decreased 63.52 11.67 166 99984 65757 110423392
Overdose 63.25 11.67 71 100079 233723 110255426
Chest discomfort 63.13 11.67 318 99832 173530 110315619
Sleep disorder 60.99 11.67 54 100096 198590 110290559
Completed suicide 60.90 11.67 78 100072 242303 110246846
Akathisia 60.36 11.67 76 100074 17037 110472112
Grip strength decreased 60.07 11.67 3 100147 80171 110408978
Pneumonitis 59.26 11.67 178 99972 76353 110412796
Hyponatraemia 57.76 11.67 366 99784 217287 110271862
Myelosuppression 56.21 11.67 9 100141 94331 110394818
Pulmonary fibrosis 55.95 11.67 12 100138 102030 110387119
Back pain 55.81 11.67 547 99603 370449 110118700
Influenza 55.65 11.67 301 99849 168800 110320349
Red blood cell sedimentation rate increased 55.43 11.67 4 100146 78298 110410851
Lung disorder 55.21 11.67 49 100101 179998 110309151
Pyrexia 55.03 11.67 1129 99021 897136 109592013
Peripheral venous disease 54.95 11.67 6 100144 84111 110405038
Sciatica 54.64 11.67 9 100141 92390 110396759
Thrombocytopenia 54.25 11.67 518 99632 348367 110140782
Heart rate abnormal 54.13 11.67 48 100102 7190 110481959
Hypercholesterolaemia 53.38 11.67 9 100141 90828 110398321
Suicide attempt 53.06 11.67 14 100136 103380 110385769
Klebsiella bacteraemia 52.62 11.67 40 100110 4829 110484320
Injection site reaction 51.95 11.67 9 100141 89061 110400088
Hair colour changes 51.65 11.67 39 100111 4662 110484487
Epilepsy 50.61 11.67 14 100136 100195 110388954
Deep vein thrombosis 50.16 11.67 255 99895 139632 110349517
Palmar-plantar erythrodysaesthesia syndrome 49.88 11.67 113 100037 40912 110448237
Streptococcal bacteraemia 49.67 11.67 38 100112 4631 110484518
Carbohydrate antigen 125 increased 49.27 11.67 30 100120 2517 110486632
Prescribed overdose 48.63 11.67 10 100140 87571 110401578
Loss of personal independence in daily activities 48.23 11.67 39 100111 149981 110339168
Embolism 47.65 11.67 66 100084 16223 110472926
Intentional product misuse 47.35 11.67 31 100119 132873 110356276
Pulmonary embolism 46.40 11.67 343 99807 214131 110275018
Dysgeusia 46.15 11.67 154 99996 69831 110419318
Anaemia 45.97 11.67 723 99427 546363 109942786
Wheezing 45.78 11.67 102 100048 255128 110234021
Intentional overdose 45.74 11.67 32 100118 132469 110356680
Urticaria 44.67 11.67 144 100006 318713 110170436
Osteoarthritis 44.60 11.67 60 100090 182563 110306586
Mental status changes 44.54 11.67 161 99989 75961 110413188
Hypoxia 44.29 11.67 233 99917 129282 110359867
Blood potassium decreased 43.93 11.67 128 100022 53986 110435163
Haemoglobin decreased 43.57 11.67 379 99771 248348 110240801
Paradoxical drug reaction 43.53 11.67 49 100101 9768 110479381
Oesophagitis 42.89 11.67 86 100064 28629 110460520
Arthralgia 42.64 11.67 476 99674 779156 109709993
Wound infection 42.56 11.67 17 100133 96448 110392701
Blood pressure increased 42.34 11.67 388 99762 257985 110231164
Maternal exposure during pregnancy 41.64 11.67 107 100043 254776 110234373
Cancer pain 41.15 11.67 40 100110 6732 110482417
Enteritis 39.55 11.67 66 100084 19090 110470059
Knee arthroplasty 39.14 11.67 6 100144 64942 110424207
Intentional product use issue 39.03 11.67 106 100044 247800 110241349
Gait inability 38.44 11.67 40 100110 136336 110352813
Neutrophil count abnormal 38.31 11.67 34 100116 5098 110484051
Lymphadenitis 38.27 11.67 35 100115 5458 110483691
Blepharospasm 38.26 11.67 3 100147 54848 110434301
Muscular weakness 38.14 11.67 368 99782 248100 110241049
Weight decreased 37.95 11.67 615 99535 467442 110021707
Injection site erythema 37.78 11.67 19 100131 94157 110394992
Off label use 37.49 11.67 1054 99096 1499131 108990018
Osteoporosis 37.41 11.67 16 100134 87136 110402013
Autoimmune disorder 37.36 11.67 7 100143 65476 110423673
Lower limb fracture 37.18 11.67 11 100139 75337 110413812
Systemic inflammatory response syndrome 36.89 11.67 52 100098 12991 110476158
Hepatic cytolysis 35.78 11.67 4 100146 55049 110434100
Liver disorder 35.48 11.67 46 100104 142197 110346952
Therapeutic response decreased 35.07 11.67 22 100128 96477 110392672
Blister 34.47 11.67 99 100051 227277 110261872
Enterocolitis infectious 34.40 11.67 27 100123 3417 110485732
Frequent bowel movements 34.18 11.67 11 100139 71379 110417770
Incorrect route of product administration 34.18 11.67 8 100142 64053 110425096
Sinus tachycardia 33.98 11.67 103 100047 44390 110444759
Hepatitis 33.46 11.67 20 100130 90034 110399115
Hypokalaemia 32.99 11.67 280 99870 182168 110306981
Musculoskeletal pain 32.93 11.67 73 100077 182950 110306199
Mucosal inflammation 32.89 11.67 173 99977 95968 110393181
Alopecia 32.64 11.67 195 99955 364558 110124591
Drug reaction with eosinophilia and systemic symptoms 32.28 11.67 17 100133 82078 110407071
Medication error 31.90 11.67 29 100121 105337 110383812
Hip arthroplasty 31.77 11.67 6 100144 55807 110433342
Performance status decreased 31.77 11.67 36 100114 7230 110481919
Nail disorder 31.38 11.67 7 100143 57928 110431221
Bone erosion 31.09 11.67 3 100147 46368 110442781
Night sweats 30.75 11.67 46 100104 133937 110355212
Therapy non-responder 30.61 11.67 60 100090 157247 110331902
Foetal heart rate abnormal 30.45 11.67 14 100136 661 110488488
Blood pressure fluctuation 30.16 11.67 15 100135 74809 110414340
Pregnancy 30.13 11.67 5 100145 51062 110438087
Rectal cancer metastatic 29.88 11.67 13 100137 538 110488611
Sedation 29.58 11.67 13 100137 69670 110419479
Hair texture abnormal 29.13 11.67 26 100124 3928 110485221
Chills 29.11 11.67 282 99868 190298 110298851
Red cell distribution width increased 29.06 11.67 55 100095 17547 110471602
Injection site swelling 28.75 11.67 10 100140 61780 110427369
Atrial fibrillation 28.58 11.67 326 99824 229316 110259833
Gastrointestinal injury 28.33 11.67 19 100131 1884 110487265
Alopecia areata 28.23 11.67 20 100130 2167 110486982
Abdominal discomfort 28.10 11.67 225 99925 393633 110095516
Coronary artery disease 27.96 11.67 15 100135 71675 110417474
Live birth 27.90 11.67 14 100136 69470 110419679
Bone pain 27.89 11.67 125 100025 65008 110424141
Product quality issue 27.57 11.67 18 100132 77281 110411868
Exposure during pregnancy 26.79 11.67 71 100079 167353 110321796
Clonus 26.53 11.67 36 100114 8680 110480469
Urinary tract infection 26.52 11.67 429 99721 325853 110163296
Colitis ulcerative 26.28 11.67 19 100131 77344 110411805
Haematocrit decreased 26.17 11.67 124 100026 65993 110423156
Eosinophilia 25.90 11.67 10 100140 57926 110431223
Oculogyric crisis 25.88 11.67 24 100126 3808 110485341
Hyperglycaemia 25.68 11.67 148 100002 84942 110404207
Depressed level of consciousness 25.33 11.67 39 100111 112239 110376910
Cough 25.19 11.67 571 99579 461070 110028079
Rhabdomyolysis 25.13 11.67 44 100106 120357 110368792
Exostosis 24.00 11.67 6 100144 45950 110443199
Ageusia 23.75 11.67 54 100096 19591 110469558
Serotonin syndrome 23.46 11.67 111 100039 59042 110430107
Cardiac failure 23.40 11.67 89 100061 187537 110301612
Bradycardia 23.35 11.67 68 100082 155449 110333700
Inappropriate schedule of product administration 23.25 11.67 100 100050 203537 110285612
Back injury 23.24 11.67 7 100143 47392 110441757
Cholestasis 23.04 11.67 15 100135 64503 110424646
Neurotoxicity 22.79 11.67 87 100063 42120 110447029
Neutropenic colitis 22.58 11.67 32 100118 8033 110481116
Cardiogenic shock 22.36 11.67 12 100138 57326 110431823
Confusional state 22.33 11.67 569 99581 468111 110021038
Starvation 22.27 11.67 13 100137 1010 110488139
Product use issue 22.25 11.67 178 99972 311517 110177632
Onychomycosis 22.23 11.67 4 100146 38527 110450622
Cytomegalovirus infection 21.81 11.67 11 100139 54433 110434716
Road traffic accident 21.74 11.67 40 100110 107358 110381791
Lymphocyte count decreased 21.68 11.67 106 100044 57137 110432012
Colon cancer metastatic 21.58 11.67 18 100132 2483 110486666
Non-small cell lung cancer 21.51 11.67 31 100119 7904 110481245
Alpha haemolytic streptococcal infection 21.41 11.67 21 100129 3572 110485577
Injection site bruising 21.08 11.67 10 100140 51253 110437896
Therapy partial responder 21.06 11.67 4 100146 37057 110452092
Blood bilirubin increased 20.91 11.67 129 100021 75843 110413306
Malignant pleural effusion 20.89 11.67 22 100128 4071 110485078
Haematochezia 20.84 11.67 46 100104 115478 110373671
Feeding disorder 20.78 11.67 54 100096 21308 110467841
Anxiety 20.46 11.67 432 99718 344646 110144503
Transposition of the great vessels 20.35 11.67 6 100144 77 110489072
Tumour marker increased 20.32 11.67 24 100126 5036 110484113
Clostridium difficile colitis 20.25 11.67 86 100064 43692 110445457
Drug dependence 20.20 11.67 10 100140 50010 110439139
Anuria 20.16 11.67 58 100092 24283 110464866
Coeliac disease 20.07 11.67 7 100143 43180 110445969
Drug-induced liver injury 19.91 11.67 50 100100 120017 110369132
Stress 19.79 11.67 41 100109 105307 110383842
Rectal haemorrhage 19.79 11.67 50 100100 119783 110369366
Cholestasis of pregnancy 19.72 11.67 13 100137 1252 110487897
Retching 19.72 11.67 55 100095 22627 110466522
Metastatic renal cell carcinoma 19.66 11.67 17 100133 2463 110486686
Injection site pruritus 19.59 11.67 11 100139 51247 110437902
Laryngitis 19.50 11.67 7 100143 42404 110446745
Extrapyramidal disorder 19.45 11.67 64 100086 28803 110460346
Appetite disorder 19.29 11.67 33 100117 9736 110479413
Hypometabolism 19.08 11.67 7 100143 184 110488965
Gastric disorder 19.04 11.67 70 100080 33287 110455862
Extensor plantar response 18.82 11.67 15 100135 1940 110487209
Dry skin 18.81 11.67 164 99986 107489 110381660
Cholangitis 18.76 11.67 44 100106 16291 110472858
Accidental exposure to product 18.73 11.67 11 100139 49997 110439152
Pruritus 18.70 11.67 393 99757 581167 109907982
Agranulocytosis 18.69 11.67 17 100133 61743 110427406
Joint stiffness 18.64 11.67 20 100130 67223 110421926
Peripheral swelling 18.52 11.67 256 99894 403778 110085371
Madarosis 18.37 11.67 19 100131 3444 110485705
Dystonia 18.10 11.67 58 100092 25747 110463402
Blood alkaline phosphatase increased 18.01 11.67 118 100032 70817 110418332
Blood creatine increased 17.80 11.67 35 100115 11486 110477663
Arthritis infective 17.73 11.67 33 100117 10396 110478753
Blood sodium decreased 17.51 11.67 75 100075 38244 110450905
Intentional self-injury 17.51 11.67 6 100144 37423 110451726
Obstructive airways disorder 17.50 11.67 10 100140 46139 110443010
Acquired cystic kidney disease 17.42 11.67 5 100145 58 110489091
Lymphadenopathy 17.32 11.67 108 100042 63727 110425422
Therapeutic response shortened 17.23 11.67 3 100147 29580 110459569
Hypertension 17.20 11.67 342 99808 509742 109979407
Anaphylactic shock 17.07 11.67 13 100137 51533 110437616
Cytopenia 17.03 11.67 63 100087 30053 110459096
Oedema 16.85 11.67 116 100034 209860 110279289
Hypermagnesaemia 16.81 11.67 13 100137 1610 110487539
Contusion 16.77 11.67 133 100017 233228 110255921
Syncope 16.71 11.67 267 99883 202269 110286880
Psychotic disorder 16.67 11.67 13 100137 50924 110438225
Abdominal infection 16.67 11.67 21 100129 4710 110484439
Heart rate decreased 16.59 11.67 31 100119 82725 110406424
Monoclonal immunoglobulin increased 16.52 11.67 9 100141 612 110488537
Intestinal perforation 16.48 11.67 49 100101 20895 110468254
Wrong technique in product usage process 16.40 11.67 34 100116 87314 110401835
Human chorionic gonadotropin decreased 16.24 11.67 5 100145 75 110489074
Acute myeloid leukaemia 16.21 11.67 73 100077 38037 110451112
Mixed dementia 16.17 11.67 7 100143 286 110488863
Breast cancer metastatic 16.12 11.67 33 100117 11148 110478001
Metastases to liver 15.97 11.67 69 100081 35317 110453832
Drug eruption 15.97 11.67 15 100135 53644 110435505
Hepatic cirrhosis 15.73 11.67 23 100127 67603 110421546
Renal cell carcinoma 15.62 11.67 26 100124 7504 110481645
Muscle twitching 15.59 11.67 61 100089 29874 110459275
Skin warm 15.57 11.67 29 100121 9141 110480008
Spinal cord compression 15.56 11.67 26 100124 7526 110481623
Fluid imbalance 15.49 11.67 9 100141 693 110488456
Tremor 15.35 11.67 263 99887 201969 110287180
Diabetes mellitus 15.25 11.67 43 100107 99338 110389811
Memory impairment 15.22 11.67 110 100040 196834 110292315
Joint dislocation 15.12 11.67 6 100144 34184 110454965
Mean cell haemoglobin concentration decreased 15.11 11.67 22 100128 5660 110483489
Foot deformity 15.09 11.67 13 100137 48467 110440682
Blood pressure systolic increased 15.00 11.67 33 100117 82958 110406191
Lymph node pain 15.00 11.67 13 100137 1889 110487260
Respiratory disorder 14.97 11.67 26 100124 71356 110417793
Large intestinal obstruction 14.82 11.67 18 100132 3890 110485259
Parkinsonism 14.78 11.67 49 100101 22138 110467011
Inferior vena caval occlusion 14.77 11.67 5 100145 103 110489046
Pneumothorax 14.57 11.67 67 100083 35218 110453931
Oesophageal ulcer 14.55 11.67 26 100124 7938 110481211
Dysphoria 14.42 11.67 23 100127 6405 110482744
Underdose 14.40 11.67 22 100128 63532 110425617
Lethargy 14.05 11.67 138 100012 93438 110395711
Skull fracture 14.00 11.67 13 100137 2067 110487082
Ear infection 13.95 11.67 22 100128 62710 110426439
Chorioretinitis 13.93 11.67 11 100139 1404 110487745
Pancreatic carcinoma metastatic 13.91 11.67 18 100132 4146 110485003
Acute kidney injury 13.89 11.67 706 99444 634724 109854425
Impaired quality of life 13.72 11.67 5 100145 30012 110459137
Mucosal dryness 13.57 11.67 18 100132 4245 110484904
Diabetes mellitus inadequate control 13.54 11.67 5 100145 29770 110459379
Breast cancer stage II 13.50 11.67 4 100146 27371 110461778
Fall 13.49 11.67 672 99478 602810 109886339
Dry mouth 13.44 11.67 116 100034 199832 110289317
Acute respiratory failure 13.33 11.67 115 100035 75145 110414004
Urinary tract infection pseudomonal 13.27 11.67 13 100137 2209 110486940
Transplant rejection 13.24 11.67 3 100147 24564 110464585
Liver iron concentration abnormal 13.12 11.67 4 100146 58 110489091
Oxygen saturation decreased 12.95 11.67 86 100064 156896 110332253
Aggression 12.94 11.67 21 100129 59189 110429960
Supraventricular tachycardia 12.91 11.67 50 100100 24372 110464777
Multiple sclerosis relapse 12.78 11.67 16 100134 50224 110438925
Pain 12.42 11.67 723 99427 954232 109534917
Diverticulitis 12.37 11.67 87 100063 53435 110435714
Blood pressure diastolic abnormal 12.32 11.67 4 100146 25811 110463338
Non-cardiac chest pain 12.29 11.67 28 100122 10170 110478979
Fear 12.17 11.67 3 100147 23190 110465959
Starvation ketoacidosis 12.16 11.67 6 100144 332 110488817
Renal cancer metastatic 11.99 11.67 8 100142 786 110488363
Disease recurrence 11.98 11.67 23 100127 60761 110428388
Hiccups 11.98 11.67 32 100118 12837 110476312
Drug tolerance decreased 11.91 11.67 5 100145 27535 110461614
Autoimmune nephritis 11.90 11.67 8 100142 796 110488353
Mass 11.89 11.67 42 100108 19588 110469561
Blood albumin decreased 11.78 11.67 53 100097 27599 110461550
Hot flush 11.74 11.67 101 100049 65935 110423214

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N05AB04 NERVOUS SYSTEM
PSYCHOLEPTICS
ANTIPSYCHOTICS
Phenothiazines with piperazine structure
FDA CS M0016525 Phenothiazines
MeSH PA D000932 Antiemetics
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D005765 Gastrointestinal Agents
MeSH PA D011619 Psychotropic Drugs
MeSH PA D014150 Antipsychotic Agents
MeSH PA D015259 Dopamine Agents
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018492 Dopamine Antagonists
FDA EPC N0000175746 Phenothiazine
CHEBI has role CHEBI:35474 anxiolytic drug
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:37890 ฮฑ-adrenergic antagonist
CHEBI has role CHEBI:48561 dopaminergic antagonist
CHEBI has role CHEBI:48873 cholinergic antagonist
CHEBI has role CHEBI:50919 antiemetic
CHEBI has role CHEBI:65190 first generation antipsychotic
CHEBI has role CHEBI:76779 EC 3.4.21.26 (prolyl oligopeptidase) inhibitor
CHEBI has role CHEBI:131787 dopamine receptor D<small><sub>2</sub></small> antagonist

Related Drugs by ATC class:

N05AB Phenothiazines with piperazine structure 9 drugs
acetophenazinebutaperazinedixyrazinefluphenazineperazineperphenazinethiopropazatethioproperazinetrifluoperazine

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Nausea and vomiting indication 16932000
Schizophrenia indication 58214004 DOID:5419
Nonpsychotic Anxiety indication
Prolonged-Severe Nausea and Vomiting indication
Migraine off-label use 37796009 DOID:6364
Chemotherapy-induced nausea and vomiting off-label use 236084000
Brain damage contraindication 2470005
Tachyarrhythmia contraindication 6285003
Urinary tract obstruction contraindication 7163005 DOID:5200
Alcoholism contraindication 7200002
Organophosphate poisoning contraindication 8260003
Weight gain finding contraindication 8943002
Severe chronic ulcerative colitis contraindication 14311001
Neuroleptic malignant syndrome contraindication 15244003 DOID:14464
Senile dementia contraindication 15662003
Chronic disease of respiratory system contraindication 17097001
Myocardial infarction contraindication 22298006 DOID:5844
Glaucoma contraindication 23986001 DOID:1686
Toxic megacolon contraindication 28536002 DOID:1770
Orthostatic hypotension contraindication 28651003
Atony of colon contraindication 29479008
Torsades de pointes contraindication 31722008
Parkinsonism contraindication 32798002
Hyperthyroidism contraindication 34486009 DOID:7998
Hypertensive disorder contraindication 38341003 DOID:10763
Complete trisomy 21 syndrome contraindication 41040004 DOID:14250
Conduction disorder of the heart contraindication 44808001
Achalasia of esophagus contraindication 45564002 DOID:9164
Chronic heart failure contraindication 48447003
Bradycardia contraindication 48867003
Paralytic ileus contraindication 55525008 DOID:8442
Peptic reflux disease contraindication 57643001
Ulcerative colitis contraindication 64766004 DOID:8577
Drug AND/OR toxin-induced diarrhea contraindication 65979008
Extrapyramidal disease contraindication 76349003
Spastic paralysis contraindication 78403003
Disturbance of salivary secretion contraindication 78948009
Hyperglycemia contraindication 80394007 DOID:4195
Hiatal hernia contraindication 84089009 DOID:12642
Epilepsy contraindication 84757009 DOID:1826
Leukopenia contraindication 84828003 DOID:615
Stupor contraindication 89458003
Kidney disease contraindication 90708001 DOID:557
Myasthenia gravis contraindication 91637004 DOID:437
Tardive dyskinesia contraindication 102449007
Prolonged QT interval contraindication 111975006
Gastrointestinal obstruction contraindication 126765001
Acute disease of cardiovascular system contraindication 128487001
Autonomic dysreflexia contraindication 129618003
Bleeding contraindication 131148009
Angina pectoris contraindication 194828000
Myocardial dysfunction contraindication 233928007
Disease of liver contraindication 235856003 DOID:409
Bladder outflow obstruction contraindication 236645006
Metabolic syndrome X contraindication 237602007 DOID:14221
Hyperprolactinemia contraindication 237662005 DOID:12700
Pyloric obstruction contraindication 244815007
Benign prostatic hyperplasia contraindication 266569009
Retention of urine contraindication 267064002
Anemia contraindication 271737000 DOID:2355
Drowsy contraindication 271782001
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Neutropenic disorder contraindication 303011007 DOID:1227
Coma contraindication 371632003
At risk for aspiration contraindication 371736008
Angle-closure glaucoma contraindication 392291006 DOID:13550
Visual impairment contraindication 397540003
Gastric ulcer contraindication 397825006 DOID:10808
Breastfeeding (mother) contraindication 413712001
Chronic lung disease contraindication 413839001
Disorder of coronary artery contraindication 414024009
Myocardial ischemia contraindication 414795007 DOID:3393
Obesity contraindication 414916001 DOID:9970
Congenital long QT syndrome contraindication 442917000
Carcinoma of female breast contraindication 447782002




๐Ÿถ Veterinary Drug Use

SpeciesUseRelation
Cats Gastrointestinal disturbances associated with emotional stress Indication
Dogs Gastrointestinal disturbances associated with emotional stress Indication

๐Ÿถ Veterinary products

ProductApplicantIngredients
Darbazine Spansule Capsule No.1 Zoetis Inc. 2
Darbazine Injectable Zoetis Inc. 2
Neo-Darbazine Spansule Capsule No.1, Neo-Darbazine Spansule Capsule No.3 Zoetis Inc. 3

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.74 Basic
pKa2 4.74 Basic
pKa3 2.21 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
D(2) dopamine receptor GPCR ANTAGONIST Ki 8.76 WOMBAT-PK CHEMBL
D(3) dopamine receptor GPCR ANTAGONIST Ki 8.61 WOMBAT-PK IUPHAR
Alpha-2A adrenergic receptor GPCR Ki 7.20 DRUG MATRIX
Sigma non-opioid intracellular receptor 1 Membrane receptor Ki 7.64 DRUG MATRIX
Potassium voltage-gated channel subfamily H member 2 Ion channel Ki 5.82 DRUG MATRIX
Sodium-dependent serotonin transporter Transporter Ki 6.21 DRUG MATRIX
Sodium-dependent noradrenaline transporter Transporter Ki 6.40 DRUG MATRIX
5-hydroxytryptamine receptor 1A GPCR Ki 5.23 PDSP
5-hydroxytryptamine receptor 2A GPCR Ki 7.82 WOMBAT-PK
5-hydroxytryptamine receptor 2B GPCR Ki 7.19 DRUG MATRIX
5-hydroxytryptamine receptor 2C GPCR Ki 6.91 WOMBAT-PK
5-hydroxytryptamine receptor 6 GPCR Ki 6.91 DRUG MATRIX
Alpha-1A adrenergic receptor GPCR Ki 7.62 WOMBAT-PK
Alpha-2B adrenergic receptor GPCR Ki 8.32 DRUG MATRIX
Histamine H1 receptor GPCR Ki 7.72 WOMBAT-PK
Muscarinic acetylcholine receptor M1 GPCR Ki 6.61 DRUG MATRIX
Muscarinic acetylcholine receptor M2 GPCR Ki 5.96 DRUG MATRIX
Muscarinic acetylcholine receptor M3 GPCR Ki 6.49 DRUG MATRIX
Muscarinic acetylcholine receptor M4 GPCR Ki 6.72 DRUG MATRIX
Muscarinic acetylcholine receptor M5 GPCR Ki 6.80 DRUG MATRIX
Alpha-2C adrenergic receptor GPCR Ki 7.92 DRUG MATRIX
Sodium-dependent dopamine transporter Transporter Ki 5.86 DRUG MATRIX
Cytochrome P450 2D6 Enzyme IC50 6.52 DRUG MATRIX
D(4) dopamine receptor GPCR Ki 7.17 WOMBAT-PK
Alpha-1D adrenergic receptor GPCR Ki 7.89 DRUG MATRIX
Cytochrome P450 1A2 Enzyme IC50 5.70 DRUG MATRIX
Tyrosine-protein kinase Fyn Kinase IC50 5.25 DRUG MATRIX
Solute carrier family 22 member 1 Transporter IC50 4.30 CHEMBL
D(1A) dopamine receptor GPCR Ki 7.11 DRUG MATRIX
Alpha-1B adrenergic receptor GPCR Ki 7.31 DRUG MATRIX
5-hydroxytryptamine receptor 1B GPCR Ki 5.92 DRUG MATRIX
Membrane-associated progesterone receptor component 1 Membrane receptor Ki 6.38 DRUG MATRIX
Alpha-1A adrenergic receptor GPCR IC50 7.49 CHEMBL
5-hydroxytryptamine receptor 1A GPCR IC50 6.02 CHEMBL
5-hydroxytryptamine receptor 4 GPCR Ki 6.71 DRUG MATRIX
Pleiotropic ABC efflux transporter of multiple drugs Transporter IC50 5.77 CHEMBL

External reference:

IDSource
4018001 VUID
N0000146346 NUI
D00479 KEGG_DRUG
84-02-6 SECONDARY_CAS_RN
1257-78-9 SECONDARY_CAS_RN
4017999 VANDF
4018000 VANDF
4018001 VANDF
C0033229 UMLSCUI
CHEBI:8435 CHEBI
CHEMBL728 ChEMBL_ID
CHEMBL1314751 ChEMBL_ID
DB00433 DRUGBANK_ID
CHEMBL1201154 ChEMBL_ID
D011346 MESH_DESCRIPTOR_UI
4917 PUBCHEM_CID
7279 IUPHAR_LIGAND_ID
699 INN_ID
YHP6YLT61T UNII
235739 RXNORM
2073 MMSL
5361 MMSL
5362 MMSL
5363 MMSL
6416 MMSL
6417 MMSL
d00355 MMSL
001478 NDDF
001479 NDDF
001480 NDDF
003466 NDDF
22827004 SNOMEDCT_US
372853006 SNOMEDCT_US
3823007 SNOMEDCT_US
395843006 SNOMEDCT_US
79129001 SNOMEDCT_US
P77 PDB_CHEM_ID
YHP6YLT61T INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
PROCHLORPERAZINE MALEATE HUMAN PRESCRIPTION DRUG LABEL 1 0440-8190 TABLET 5 mg ORAL ANDA 12 sections
Compro HUMAN PRESCRIPTION DRUG LABEL 1 0574-7226 SUPPOSITORY 25 mg RECTAL ANDA 19 sections
Prochlorperazine Edisylate HUMAN PRESCRIPTION DRUG LABEL 1 0641-6135 INJECTION 5 mg INTRAMUSCULAR ANDA 18 sections
Prochlorperazine HUMAN PRESCRIPTION DRUG LABEL 1 0713-0135 SUPPOSITORY 25 mg RECTAL ANDA 13 sections
Prochlorperazine Edisylate HUMAN PRESCRIPTION DRUG LABEL 1 0713-0351 INJECTION 5 mg INTRAMUSCULAR ANDA 13 sections
Prochlorperazine Maleate HUMAN PRESCRIPTION DRUG LABEL 1 0904-7381 TABLET 5 mg ORAL ANDA 13 sections
Prochlorperazine Maleate HUMAN PRESCRIPTION DRUG LABEL 1 0904-7382 TABLET 10 mg ORAL ANDA 13 sections
PROCHLORPERAZINE MALEATE HUMAN PRESCRIPTION DRUG LABEL 1 10544-281 TABLET 10 mg ORAL ANDA 12 sections
PROCHLORPERAZINE MALEATE HUMAN PRESCRIPTION DRUG LABEL 1 10544-511 TABLET 5 mg ORAL ANDA 12 sections
PROCHLORPERAZINE HUMAN PRESCRIPTION DRUG LABEL 1 16590-327 TABLET 10 mg ORAL ANDA 10 sections
PROCHLORPERAZINE MALEATE HUMAN PRESCRIPTION DRUG LABEL 1 21695-571 TABLET 5 mg ORAL ANDA 12 sections
PROCHLORPERAZINE MALEATE HUMAN PRESCRIPTION DRUG LABEL 1 21695-572 TABLET 10 mg ORAL ANDA 12 sections
Prochlorperazine Edisylate HUMAN PRESCRIPTION DRUG LABEL 1 23155-294 INJECTION 5 mg INTRAMUSCULAR ANDA 13 sections
Prochlorperazine Edisylate HUMAN PRESCRIPTION DRUG LABEL 1 23155-523 INJECTION 5 mg INTRAMUSCULAR ANDA 13 sections
PROCHLORPERAZINE EDISYLATE HUMAN PRESCRIPTION DRUG LABEL 1 25021-790 INJECTION 5 mg INTRAVENOUS ANDA 18 sections
Prochlorperazine Maleate Human Prescription Drug Label 1 27241-286 TABLET 5 mg ORAL ANDA 11 sections
Prochlorperazine Maleate Human Prescription Drug Label 1 27241-287 TABLET 10 mg ORAL ANDA 11 sections
PROCHLORPERAZINE MALEATE HUMAN PRESCRIPTION DRUG LABEL 1 33261-141 TABLET 5 mg ORAL ANDA 12 sections
PROCHLORPERAZINE MALEATE HUMAN PRESCRIPTION DRUG LABEL 1 33261-550 TABLET 10 mg ORAL ANDA 12 sections
PROCHLORPERAZINE MALEATE HUMAN PRESCRIPTION DRUG LABEL 1 42708-103 TABLET 10 mg ORAL ANDA 12 sections
PROCHLORPERAZINE MALEATE HUMAN PRESCRIPTION DRUG LABEL 1 43063-742 TABLET 10 mg ORAL ANDA 12 sections
PROCHLORPERAZINE EDISYLATE HUMAN PRESCRIPTION DRUG LABEL 1 43066-090 INJECTION 5 mg INTRAMUSCULAR ANDA 17 sections
PROCHLORPERAZINE EDISYLATE HUMAN PRESCRIPTION DRUG LABEL 1 43066-090 INJECTION 5 mg INTRAMUSCULAR ANDA 17 sections
Prochlorperazine Maleate HUMAN PRESCRIPTION DRUG LABEL 1 50090-0109 TABLET, FILM COATED 5 mg ORAL ANDA 15 sections
Prochlorperazine HUMAN PRESCRIPTION DRUG LABEL 1 50090-0636 SUPPOSITORY 25 mg RECTAL ANDA 13 sections
PROCHLORPERAZINE MALEATE Human Prescription Drug Label 1 50090-2241 TABLET 5 mg ORAL ANDA 12 sections
PROCHLORPERAZINE MALEATE Human Prescription Drug Label 1 50090-2839 TABLET 10 mg ORAL ANDA 12 sections
Prochlorperazine Edisylate HUMAN PRESCRIPTION DRUG LABEL 1 50090-4548 INJECTION 5 mg INTRAMUSCULAR ANDA 14 sections
PROCHLORPERAZINE MALEATE HUMAN PRESCRIPTION DRUG LABEL 1 50090-7147 TABLET, FILM COATED 5 mg ORAL ANDA 11 sections
PROCHLORPERAZINE MALEATE HUMAN PRESCRIPTION DRUG LABEL 1 50090-7634 TABLET 5 mg ORAL ANDA 11 sections