pimethixene 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
2169 314-03-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • pimethixene
  • calmixen
  • mepithiathene
  • pimetixene
  • pimethixene maleate
  • Molecular weight: 293.43
  • Formula: C19H19NS
  • CLOGP: 4.92
  • LIPINSKI: 0
  • HAC: 1
  • HDO: 0
  • TPSA: 3.24
  • ALOGS: -4.83
  • ROTB: 0

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2B,AKT2,AXL,BRAF,CAMK2B,CAMK2D,CDK5,CDK9,DYRK1B,EIF2AK3,EPHB4,ERBB2,GRK2,ITK,JAK2,MAP3K7,MAPK10,MAPK7,MET,NTRK2,PDK4,PDPK1,PIM2,PRKDC,STK33,TEK,TTK 27
kinase-selectivity-class AXL 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC R06AX23 RESPIRATORY SYSTEM
ANTIHISTAMINES FOR SYSTEMIC USE
ANTIHISTAMINES FOR SYSTEMIC USE
Other antihistamines for systemic use

Related Drugs by ATC class:

R06AX Other antihistamines for systemic use 26 drugs
acrivastineantazolineastemizoleazatadineazelastinebamipinebilastinecyproheptadinedeptropinedesloratadineebastineepinastine show all 26 →

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.8 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Histone-lysine N-methyltransferase SETD7 Enzyme IC50 5.37 CHEMBL
5-hydroxytryptamine receptor 2A GPCR Ki 8.60 CHEMBL
Transcriptional activator protein luxR Transcription factor IC50 4.25 CHEMBL

External reference:

IDSource
D07406 KEGG_DRUG
C0071069 UMLSCUI
CHEBI:94787 CHEBI
CHEMBL152408 ChEMBL_ID
DB13292 DRUGBANK_ID
C004327 MESH_SUPPLEMENTAL_RECORD_UI
4822 PUBCHEM_CID
1739 INN_ID
13187-06-9 SECONDARY_CAS_RN
T46J20J26F UNII
33712 RXNORM
005718 NDDF
CHEMBL1523827 ChEMBL_ID
T46J20J26F INXIGHT DRUGS

Pharmaceutical products:

None