opipramol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
substances of the imipramine group 1993 315-72-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • opipramol dihydrochloride
  • opipramol
  • opramidol
A tricyclic antidepressant with actions similar to AMITRIPTYLINE.
  • Molecular weight: 363.51
  • Formula: C23H29N3O
  • CLOGP: 3.65
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 29.95
  • ALOGS: -3.54
  • ROTB: 6

Drug dosage:

DoseUnitRoute
0.15 g O

ADMET properties:

PropertyValueReference
BA (Bioavailability) 94 %

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,AKT1,AKT2,AKT3,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,CHEK1,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,ITK,JAK2,JAK3,MAP3K21,MAP3K7,MAPK10,MAPK12,MAPK7,MAPK9,MAPKAPK2,MARK4,MET,MTOR,NTRK2,PAK4,PDK2,PDK4,PDPK1,PIK3CB,PIM2,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ULK1 53
kinase-selectivity-class AXL,BRAF,CAMK2D,CDK4,EPHB4,PDK4,SIK2,SIK3,STK33 9
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
General physical health deterioration 183.84 35.27 117 2417 354998 90270915
Product prescribing error 74.61 35.27 29 2505 30116 90595797
Product monitoring error 61.55 35.27 16 2518 4528 90621385
Labelled drug-drug interaction medication error 43.17 35.27 16 2518 14566 90611347
Patient uncooperative 40.49 35.27 7 2527 277 90625636
Fall 39.07 35.27 57 2477 481753 90144160
Skin irritation 36.90 35.27 14 2520 13589 90612324
Pneumobilia 36.82 35.27 6 2528 165 90625748

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Transposition of the great vessels 45.74 38.59 8 884 457 42619986
VACTERL syndrome 44.95 38.59 6 886 53 42620390
Hypoparathyroidism secondary 44.85 38.59 7 885 197 42620246
Visual evoked potentials abnormal 43.84 38.59 6 886 65 42620378
CADASIL 41.50 38.59 6 886 99 42620344
Magnetic resonance imaging spinal abnormal 39.52 38.59 6 886 140 42620303
Hemivertebra 39.48 38.59 6 886 141 42620302
Saccadic eye movement 38.71 38.59 6 886 161 42620282

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
General physical health deterioration 191.23 31.05 128 2939 425167 110161065
Product prescribing error 78.68 31.05 35 3032 51296 110534936
Product monitoring error 50.99 31.05 16 3051 8911 110577321
Hypoparathyroidism secondary 40.42 31.05 7 3060 282 110585950
Fall 34.95 31.05 61 3006 603421 109982811
Pneumobilia 32.93 31.05 6 3061 324 110585908
Patient uncooperative 32.04 31.05 7 3060 953 110585279
Tachycardia 31.52 31.05 35 3032 226610 110359622
Skin irritation 31.13 31.05 13 3054 16306 110569926

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N06AA05 NERVOUS SYSTEM
PSYCHOANALEPTICS
ANTIDEPRESSANTS
Non-selective monoamine reuptake inhibitors
MeSH PA D000928 Antidepressive Agents
MeSH PA D000929 Antidepressive Agents, Tricyclic
MeSH PA D011619 Psychotropic Drugs
MeSH PA D014179 Neurotransmitter Uptake Inhibitors
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018663 Adrenergic Agents
MeSH PA D018759 Adrenergic Uptake Inhibitors
MeSH PA D049990 Membrane Transport Modulators

Related Drugs by ATC class:

N06AA Non-selective monoamine reuptake inhibitors 20 drugs
amineptineamitriptylineamoxapinebutriptylineclomipraminedesipraminedibenzepindimetacrinedosulepindoxepinimipramineimipramine oxide show all 20 →

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Depressive disorder indication 35489007




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.21 Basic
pKa2 5.43 Basic
pKa3 4.21 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Sigma non-opioid intracellular receptor 1 Membrane receptor Ki 9.70 CHEMBL
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase Enzyme Ki 7.89 CHEMBL
Voltage-dependent N-type calcium channel subunit alpha-1B Ion channel IC50 4.62 CHEMBL
C-8 sterol isomerase Enzyme Ki 7.77 CHEMBL

External reference:

IDSource
N0000167254 NUI
D08297 KEGG_DRUG
C0029105 UMLSCUI
CHEBI:94614 CHEBI
CHEMBL370753 ChEMBL_ID
CHEMBL1524185 ChEMBL_ID
DB12930 DRUGBANK_ID
D009888 MESH_DESCRIPTOR_UI
9417 PUBCHEM_CID
11247 IUPHAR_LIGAND_ID
1838 INN_ID
D23ZXO613C UNII
7674 RXNORM
004149 NDDF
004150 NDDF
1156223004 SNOMEDCT_US
1172808004 SNOMEDCT_US
1172810002 SNOMEDCT_US
D23ZXO613C INXIGHT DRUGS

Pharmaceutical products:

None