nortriptyline 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
antidepressants, dibenzo[a,d]cycloheptane or cyclopheptene derivatives 1971 72-69-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • nortryptyline
  • nortriptyline
  • demethylamitriptylin
  • desitriptilina
  • desmethylamitriptyline
  • noramitriptyline
  • nortriptyline hydrochloride
  • nortriptyline HCl
A metabolite of AMITRIPTYLINE that is also used as an antidepressive agent. Nortriptyline is used in major depression, dysthymia, and atypical depressions.
  • Molecular weight: 263.38
  • Formula: C19H21N
  • CLOGP: 4.32
  • LIPINSKI: 0
  • HAC: 1
  • HDO: 1
  • TPSA: 12.03
  • ALOGS: -5.48
  • ROTB: 3
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
75 mg O
30 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 2 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 6.34 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 51 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 22 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 10 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.12 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 30 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 1.847 High 1
caco2-efflux Caco-2 efflux ratio (BA/AB) 0.501 High 1
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 37.325 10^-6 cm/s High 1
dh-clint Dog hepatocyte intrinsic clearance 77.268 uL/min/10^6 cells High 1
dppb Dog plasma protein binding (% unbound) 5.310 % High 1
fcs-ppb Fetal calf serum protein binding (% unbound) 20.980 % High 1
herg hERG pIC50 5.370 pIC50 High 1
hh-clint Human hepatocyte intrinsic clearance 8.531 uL/min/10^6 cells High 1
hlm-clint Human liver microsomal intrinsic clearance 7.998 uL/min/mg protein High 1
hppb Human plasma protein binding (% unbound) 13.440 % High 1
kinase-safety-class ACVR2B,AKT1,AKT2,AKT3,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,ITK,JAK2,JAK3,MAP3K7,MAPK10,MAPK12,MAPK7,MAPKAPK2,MET,NTRK2,PDK2,PDK4,PDPK1,PIM2,PRKDC,SIK2,SIK3,TEK,TGFBR1,TTK 39
kinase-selectivity-class AXL,BRAF,EIF2AK3,GRK2,PDK4,TTK 6
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 0.741 High 1
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 0.532 High 1
mh-clint Mouse hepatocyte intrinsic clearance 150.661 High 1
mppb Mouse plasma protein binding (% unbound) 4.980 High 1
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 2.685 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pld-class Phospholipidosis risk class (1 = positive, 0 = negative) 1 High 1
pppb Pig plasma protein binding (% unbound) 19.130 % High 1
rat-kpuu-brain Rat brain Kpuu 0.240 % High 1
rh-clint Rat hepatocyte intrinsic clearance 404.576 uL/min/10^6 cells High 1
rh-fuinc Rat hepatocyte fraction unbound in incubation 27.590 % High 1
rppb Rat plasma protein binding (% unbound) 10.470 % High 1
solubility-dd Solubility at pH 7.4 in DMSO 903.649 uM High 1

Approvals:

DateAgencyCompanyOrphan
Nov. 6, 1964 FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Food allergy 985.06 13.22 397 44649 25081 90558320
Temperature regulation disorder 892.86 13.22 318 44728 14261 90569140
Immunodeficiency 828.02 13.22 412 44634 42822 90540579
Rash erythematous 587.28 13.22 379 44667 64725 90518676
Hyperhidrosis 506.02 13.22 468 44578 135837 90447564
Coeliac disease 470.85 13.22 287 44759 44323 90539078
Upper respiratory tract infection 423.63 13.22 413 44633 127905 90455496
Overdose 407.59 13.22 445 44601 157264 90426137
Fluid retention 403.70 13.22 341 44705 87750 90495651
Completed suicide 397.12 13.22 422 44624 144636 90438765
Foetal death 389.14 13.22 195 44851 20528 90562873
Intentional product misuse 317.50 13.22 300 44746 89304 90494097
Pneumonia aspiration 305.59 13.22 212 44834 40728 90542673
Prescribed overdose 303.08 13.22 304 44742 97321 90486080
Asthma 283.79 13.22 464 44582 241696 90341705
Bursitis 224.39 13.22 301 44745 131353 90452048
Toxicity to various agents 202.90 13.22 444 44602 287402 90295999
Coma 197.97 13.22 211 44835 72421 90510980
Back pain 193.42 13.22 462 44584 316713 90266688
Constipation 192.52 13.22 428 44618 279967 90303434
Rheumatoid arthritis 187.46 13.22 496 44550 362118 90221283
Drug hypersensitivity 179.79 13.22 572 44474 463037 90120364
Erythema 165.31 13.22 357 44689 228889 90354512
Neovascularisation 156.96 13.22 50 44996 1580 90581821
Presbyacusis 151.44 13.22 57 44989 2985 90580416
Somnolence 151.17 13.22 326 44720 208758 90374643
Hepatic enzyme increased 147.93 13.22 454 44592 360282 90223119
Hypersensitivity 146.22 13.22 527 44519 454150 90129251
Pleural fibrosis 145.65 13.22 58 44988 3538 90579863
Synovitis 145.33 13.22 4 45042 329748 90253653
Psoriasis 143.79 13.22 261 44785 147493 90435908
Exposure during pregnancy 141.68 13.22 344 44702 238066 90345335
Pleural thickening 140.71 13.22 55 44991 3193 90580208
Blood magnesium increased 134.67 13.22 54 44992 3354 90580047
Hand deformity 132.85 13.22 3 45043 296359 90287042
Glossodynia 128.23 13.22 8 45038 321771 90261630
Deafness neurosensory 127.28 13.22 64 44982 6777 90576624
Product use issue 125.80 13.22 405 44641 329514 90253887
Osteopenia 124.07 13.22 98 44948 22904 90560497
Headache 121.74 13.22 788 44258 861958 89721443
Systemic lupus erythematosus 120.73 13.22 18 45028 361878 90221523
Brugada syndrome 120.45 13.22 31 45015 444 90582957
Treatment failure 114.85 13.22 372 44674 303556 90279845
Electrocardiogram QRS complex prolonged 111.63 13.22 60 44986 7288 90576113
Pericarditis 109.81 13.22 6 45040 270145 90313256
Thrombocytopenia 109.16 13.22 287 44759 208438 90374963
Wound 103.54 13.22 14 45032 302966 90280435
Gastrooesophageal reflux disease 100.87 13.22 242 44804 166095 90417306
Epigastric discomfort 99.02 13.22 56 44990 7512 90575889
Paradoxical drug reaction 98.72 13.22 51 44995 5715 90577686
Decreased immune responsiveness 94.06 13.22 57 44989 8691 90574710
Rubber sensitivity 91.90 13.22 39 45007 2798 90580603
Bone cyst 88.18 13.22 36 45010 2342 90581059
Swelling 87.22 13.22 50 44996 419008 90164393
Alopecia 81.10 13.22 76 44970 494995 90088406
Helicobacter infection 78.65 13.22 10 45036 226840 90356561
Vascular malformation 76.27 13.22 24 45022 728 90582673
Lower respiratory tract infection 75.88 13.22 16 45030 250643 90332758
Muscle injury 74.76 13.22 3 45043 176651 90406750
Paranasal cyst 74.52 13.22 24 45022 786 90582615
Drug ineffective for unapproved indication 74.22 13.22 125 44921 66519 90516882
Stomatitis 72.71 13.22 23 45023 274675 90308726
Sensitivity to weather change 70.82 13.22 48 44998 8866 90574535
Impaired healing 70.79 13.22 15 45031 234184 90349217
Type 2 diabetes mellitus 70.35 13.22 9 45037 203235 90380166
Cyst 69.44 13.22 61 44985 16500 90566901
Rheumatoid factor positive 69.15 13.22 4 45042 171646 90411755
Mastoiditis 67.85 13.22 27 45019 1643 90581758
Hypertension 66.73 13.22 422 44624 457110 90126291
Rheumatic fever 63.47 13.22 3 45043 153118 90430283
Forced expiratory volume decreased 62.84 13.22 38 45008 5770 90577631
Osteosclerosis 62.07 13.22 34 45012 4286 90579115
Pain 60.66 13.22 758 44288 995583 89587818
Extrapyramidal disorder 60.38 13.22 56 44990 16247 90567154
Ill-defined disorder 59.79 13.22 10 45036 184881 90398520
Cervicogenic headache 59.48 13.22 15 45031 197 90583204
Abdominal discomfort 59.29 13.22 91 44955 477237 90106164
Irritable bowel syndrome 59.28 13.22 15 45031 207433 90375968
General physical health deterioration 58.72 13.22 54 44992 355061 90228340
Drug intolerance 58.08 13.22 401 44645 447190 90136211
Poor venous access 57.22 13.22 59 44987 19468 90563933
Somatic delusion 55.70 13.22 18 45028 596 90582805
Pineal gland cyst 54.69 13.22 14 45032 196 90583205
Blood potassium increased 54.24 13.22 59 44987 20690 90562711
Neutropenia 54.11 13.22 22 45024 224882 90358519
Joint range of motion decreased 52.17 13.22 4 45042 135639 90447762
Traumatic coma 52.05 13.22 11 45035 61 90583340
Anuria 51.24 13.22 49 44997 14769 90568632
C-reactive protein abnormal 51.23 13.22 3 45043 127426 90455975
Off label use 50.30 13.22 797 44249 1101455 89481946
Injury 49.64 13.22 18 45028 197331 90386070
Vomiting 49.35 13.22 213 44833 788080 89795321
Infusion related reaction 48.61 13.22 364 44682 416416 90166985
Confusional state 48.54 13.22 73 44973 386132 90197269
Blister 48.10 13.22 34 45012 254964 90328437
Psoriatic arthropathy 47.81 13.22 27 45019 228308 90355093
Wheezing 45.90 13.22 31 45015 238049 90345352
Suspected suicide 45.74 13.22 38 45008 9530 90573871
Maternal exposure during pregnancy 45.30 13.22 68 44978 359995 90223406
Pancytopenia 44.99 13.22 4 45042 120259 90463142
Dry eye 43.71 13.22 92 44954 57839 90525562
Swollen joint count increased 43.56 13.22 3 45043 111203 90472198
Unresponsive to stimuli 41.77 13.22 71 44975 38050 90545351
Arthropathy 41.56 13.22 74 44972 366168 90217233
Fatigue 41.34 13.22 803 44243 1153220 89430181
Spinal stenosis 41.17 13.22 47 44999 17377 90566024
Joint swelling 40.55 13.22 405 44641 502895 90080506
Pneumonia 40.14 13.22 172 44874 637887 89945514
Serotonin syndrome 39.46 13.22 69 44977 37818 90545583
Polymyositis 39.41 13.22 20 45026 2159 90581242
Night sweats 39.40 13.22 8 45038 128758 90454643
Skin lesion 38.85 13.22 68 44978 37297 90546104
Lip dry 38.75 13.22 3 45043 100952 90482449
Hypercholesterolaemia 38.72 13.22 3 45043 100889 90482512
Liver disorder 38.24 13.22 7 45039 121262 90462139
Asthenia 37.28 13.22 138 44908 533613 90049788
Febrile neutropenia 37.26 13.22 16 45030 158333 90425068
Migraine without aura 37.05 13.22 14 45032 741 90582660
Contraindicated product administered 36.95 13.22 279 44767 319860 90263541
Disease progression 36.57 13.22 16 45030 156599 90426802
Wound infection 36.12 13.22 5 45041 106397 90477004
Anaemia 35.92 13.22 76 44970 352726 90230675
Suicidal ideation 34.98 13.22 98 44948 73757 90509644
Deformity 34.27 13.22 36 45010 12134 90571267
Blood cholesterol increased 33.92 13.22 32 45014 207980 90375421
C-reactive protein increased 33.14 13.22 25 45021 181364 90402037
Lung disorder 32.42 13.22 17 45029 149866 90433535
Pulmonary fibrosis 32.23 13.22 7 45039 107496 90475905
Nasopharyngitis 31.98 13.22 100 44946 407004 90176397
Malignant neoplasm progression 31.96 13.22 7 45039 106863 90476538
Migraine 31.75 13.22 182 44864 190210 90393191
Sinusitis 31.61 13.22 78 44968 343010 90240391
Cardiac arrest 31.37 13.22 119 44927 104816 90478585
Dyspnoea 31.18 13.22 284 44762 880671 89702730
Unmasking of previously unidentified disease 31.00 13.22 15 45031 1461 90581940
Decreased appetite 30.64 13.22 91 44955 376449 90206952
Grip strength decreased 29.94 13.22 5 45041 92571 90490830
Retching 29.86 13.22 42 45004 19117 90564284
Bone density abnormal 29.84 13.22 21 45025 4119 90579282
Occult blood 29.60 13.22 14 45032 1297 90582104
Hypoventilation 29.49 13.22 23 45023 5273 90578128
Alanine aminotransferase abnormal 29.00 13.22 23 45023 5403 90577998
Urticaria 28.89 13.22 71 44975 312663 90270738
Gastrointestinal motility disorder 28.72 13.22 24 45022 6067 90577334
Hysterectomy 28.65 13.22 32 45014 11552 90571849
Acute kidney injury 28.61 13.22 74 44972 320313 90263088
Infection 28.46 13.22 290 44756 361804 90221597
Red blood cell sedimentation rate increased 27.75 13.22 4 45042 82591 90500810
Otitis media 27.41 13.22 23 45023 5847 90577554
Femoral neck fracture 26.58 13.22 29 45017 10204 90573197
Contusion 26.50 13.22 53 44993 251163 90332238
Peripheral venous disease 26.12 13.22 5 45041 83916 90499485
Ligamentum flavum hypertrophy 26.04 13.22 9 45037 368 90583033
Cervical dysplasia 25.74 13.22 19 45027 4015 90579386
Gait inability 25.72 13.22 21 45025 146435 90436966
Peripheral swelling 25.54 13.22 112 44934 412994 90170407
Autoimmune disorder 25.14 13.22 4 45042 76740 90506661
Immune thrombocytopenia 25.03 13.22 32 45014 13294 90570107
Oedema 25.00 13.22 38 45008 200257 90383144
Arthralgia 24.97 13.22 257 44789 778265 89805136
Disturbance in attention 24.80 13.22 65 44981 47044 90536357
Systolic dysfunction 24.67 13.22 14 45032 1890 90581511
Prescribed underdose 24.37 13.22 4 45042 75015 90508386
Oedema peripheral 24.25 13.22 58 44988 257857 90325544
Genital erosion 24.23 13.22 9 45037 454 90582947
Live birth 24.02 13.22 5 45041 79102 90504299
Accidental death 23.72 13.22 14 45032 2034 90581367
Electrocardiogram ST segment elevation 23.58 13.22 18 45028 3998 90579403
Blood pressure abnormal 23.41 13.22 38 45008 19607 90563794
Epilepsy 23.36 13.22 6 45040 82200 90501201
Electrocardiogram repolarisation abnormality 23.06 13.22 12 45034 1364 90582037
Hip arthroplasty 22.77 13.22 5 45041 76203 90507198
Ventricular tachyarrhythmia 22.51 13.22 7 45039 204 90583197
Pruritus 21.62 13.22 169 44877 541356 90042045
Sepsis 21.60 13.22 35 45011 179779 90403622
Hepatic cirrhosis 21.40 13.22 3 45043 63250 90520151
Vitamin B12 decreased 21.15 13.22 19 45027 5291 90578110
Intentional product use issue 21.01 13.22 48 44998 216844 90366557
Alanine aminotransferase increased 20.74 13.22 17 45029 118321 90465080
Arthritis 20.63 13.22 32 45014 167283 90416118
Carpal tunnel syndrome 20.42 13.22 40 45006 23888 90559513
Discomfort 20.41 13.22 69 44977 274266 90309135
Failed induction of labour 20.39 13.22 8 45038 469 90582932
Renal failure 20.37 13.22 21 45025 130986 90452415
Pleural rub 20.02 13.22 5 45041 63 90583338
Drug ineffective 20.00 13.22 859 44187 1383439 89199962
Anal abscess 19.97 13.22 19 45027 5689 90577712
Hyperkalaemia 19.95 13.22 4 45042 64960 90518441
Respiratory arrest 19.66 13.22 48 44998 33263 90550138
Oral discomfort 19.42 13.22 25 45021 10458 90572943
Oesophageal irritation 19.22 13.22 7 45039 334 90583067
Musculoskeletal pain 19.04 13.22 35 45011 171216 90412185
Vertebral lateral recess stenosis 19.00 13.22 7 45039 345 90583056
Liver injury 18.84 13.22 35 45011 170532 90412869
Osteoarthropathy 18.70 13.22 7 45039 361 90583040
Obesity 18.68 13.22 15 45031 105492 90477909
Iodine allergy 18.60 13.22 9 45037 877 90582524
Procedural pain 18.56 13.22 47 44999 33313 90550088
Pleural effusion 18.52 13.22 17 45029 111974 90471427
Sciatica 18.48 13.22 14 45032 101368 90482033
Lower limb fracture 17.86 13.22 10 45036 85003 90498398
Stress 17.85 13.22 84 44962 81311 90502090
Heart rate increased 17.56 13.22 106 44940 112796 90470605
Spinal osteoarthritis 17.56 13.22 33 45013 19115 90564286
Septic shock 17.53 13.22 10 45036 84150 90499251
Abnormal faeces 17.46 13.22 19 45027 6663 90576738
Postmortem blood drug level increased 17.27 13.22 8 45038 707 90582694
Abdominal pain upper 17.21 13.22 96 44950 332578 90250823
Intentional overdose 17.16 13.22 92 44954 93742 90489659
Drug-induced liver injury 17.07 13.22 12 45034 90306 90493095
Bone hypertrophy 16.93 13.22 7 45039 470 90582931
Antidepressant drug level above therapeutic 16.75 13.22 7 45039 483 90582918
Herpes dermatitis 16.70 13.22 5 45041 128 90583273
Inappropriate schedule of product administration 16.34 13.22 129 44917 149804 90433597
Urine odour abnormal 16.21 13.22 19 45027 7225 90576176
Hyperaesthesia 16.00 13.22 23 45023 10679 90572722
Tardive dyskinesia 15.63 13.22 23 45023 10907 90572494
Threatened labour 15.54 13.22 8 45038 890 90582511
Noninfectious myelitis 15.43 13.22 3 45043 10 90583391
Malaise 15.43 13.22 202 44844 585784 89997617
Long QT syndrome 15.21 13.22 14 45032 4023 90579378
Road traffic accident 14.84 13.22 19 45027 107607 90475794
Mucosal erosion 14.81 13.22 10 45036 1835 90581566
Antidepressant drug level increased 14.67 13.22 6 45040 392 90583009
Essential tremor 14.66 13.22 9 45037 1403 90581998
Allodynia 14.55 13.22 8 45038 1016 90582385
Ascites 14.53 13.22 3 45043 47737 90535664
Aspartate aminotransferase increased 14.37 13.22 18 45028 102919 90480482
Therapeutic product effect incomplete 14.26 13.22 49 44997 193847 90389554
Atrial fibrillation 14.24 13.22 28 45018 133583 90449818
Dystonia 14.21 13.22 28 45018 16791 90566610
Acute lung injury 14.18 13.22 9 45037 1489 90581912
Medication overuse headache 14.16 13.22 9 45037 1492 90581909
Hyperreflexia 14.13 13.22 17 45029 6640 90576761
Neuropathy peripheral 13.92 13.22 116 44930 136854 90446547
Hepatitis 13.90 13.22 9 45037 70730 90512671
Hepatic function abnormal 13.90 13.22 3 45043 46285 90537116
Mobility decreased 13.71 13.22 71 44975 250663 90332738
Hepatotoxicity 13.71 13.22 3 45043 45839 90537562
Tremor 13.64 13.22 126 44920 153047 90430354
Toe operation 13.57 13.22 8 45038 1160 90582241
Hypokalaemia 13.53 13.22 28 45018 131088 90452313

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Sedation 599.10 17.65 250 11995 30225 42578865
Nightmare 440.79 17.65 190 12055 24822 42584268
Toxicity to various agents 435.02 17.65 423 11822 228713 42380377
Nephrolithiasis 302.56 17.65 166 12079 36664 42572426
Hyperhidrosis 258.16 17.65 211 12034 90301 42518789
Completed suicide 208.45 17.65 192 12053 96273 42512817
Cerebral hypoperfusion 151.24 17.65 39 12206 1004 42608086
Reversible airways obstruction 140.45 17.65 33 12212 570 42608520
Drug abuse 131.42 17.65 156 12089 104615 42504475
Drug ineffective 115.99 17.65 419 11826 629778 41979312
Product use in unapproved indication 115.51 17.65 197 12048 184259 42424831
Overdose 109.93 17.65 143 12102 105121 42503969
Nausea 96.05 17.65 290 11955 396509 42212581
Product used for unknown indication 95.47 17.65 28 12217 1173 42607917
Poisoning 87.94 17.65 54 12191 14645 42594445
Myokymia 82.02 17.65 16 12229 106 42608984
Inspiratory capacity decreased 81.29 17.65 31 12214 2936 42606154
Arteriosclerosis coronary artery 80.81 17.65 56 12189 18621 42590469
Drug dependence 78.87 17.65 66 12179 29028 42580062
Binocular eye movement disorder 78.01 17.65 18 12227 286 42608804
Suicidal ideation 77.94 17.65 82 12163 48079 42561011
Off label use 72.40 17.65 367 11878 637968 41971122
Cardio-respiratory arrest 67.99 17.65 84 12161 58552 42550538
Phonophobia 47.01 17.65 12 12233 296 42608794
Cerebellar stroke 46.91 17.65 14 12231 623 42608467
Depression 43.88 17.65 98 12147 111265 42497825
Speech disorder 40.83 17.65 46 12199 29075 42580015
Feeling cold 40.56 17.65 32 12213 12941 42596149
Serotonin syndrome 38.25 17.65 42 12203 25803 42583287
Feelings of worthlessness 36.87 17.65 10 12235 314 42608776
Electrocardiogram QRS complex prolonged 36.37 17.65 22 12223 5801 42603289
Craniofacial fracture 34.85 17.65 10 12235 387 42608703
Hyporesponsive to stimuli 34.76 17.65 14 12231 1532 42607558
Drug ineffective for unapproved indication 33.75 17.65 53 12192 46110 42562980
Brugada syndrome 32.47 17.65 12 12233 1041 42608049
Anaemia 31.44 17.65 21 12224 280257 42328833
Trigeminal neuralgia 31.16 17.65 13 12232 1556 42607534
Pyrexia 29.77 17.65 42 12203 394000 42215090
Suicide attempt 29.72 17.65 50 12195 46050 42563040
Thrombocytopenia 29.52 17.65 9 12236 190270 42418820
Abulia 29.41 17.65 10 12235 680 42608410
Impaired quality of life 28.16 17.65 27 12218 14150 42594940
Post-traumatic stress disorder 26.48 17.65 13 12232 2272 42606818
Obsessive-compulsive disorder 26.33 17.65 19 12226 6724 42602366
Gait disturbance 25.75 17.65 74 12171 97926 42511164
Accidental death 25.54 17.65 14 12231 3069 42606021
Decreased interest 24.23 17.65 13 12232 2732 42606358
On and off phenomenon 24.01 17.65 14 12231 3453 42605637
General physical health deterioration 23.73 17.65 7 12238 151239 42457851
Transcription medication error 23.17 17.65 7 12238 325 42608765
Suspected suicide 23.14 17.65 17 12228 6182 42602908
Antidepressant discontinuation syndrome 22.61 17.65 4 12241 14 42609076
Depressed level of consciousness 22.07 17.65 45 12200 47925 42561165
Nocturia 22.06 17.65 22 12223 12090 42597000
Frustration tolerance decreased 22.04 17.65 13 12232 3273 42605817
Viral pharyngitis 21.86 17.65 6 12239 197 42608893
Benzodiazepine drug level therapeutic 20.85 17.65 4 12241 24 42609066
Febrile neutropenia 20.69 17.65 14 12231 185689 42423401
Diarrhoea 20.64 17.65 66 12179 460783 42148307
Restless legs syndrome 20.41 17.65 19 12226 9595 42599495
Respiratory depression 20.20 17.65 26 12219 18842 42590248
Substance abuse 19.69 17.65 18 12227 8887 42600203
Fall 19.15 17.65 124 12121 234396 42374694
Drug hypersensitivity 18.76 17.65 67 12178 99322 42509768
Vertigo 17.95 17.65 34 12211 34313 42574777

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Temperature regulation disorder 828.12 13.65 282 48259 12544 110528214
Food allergy 713.65 13.65 284 48257 19664 110521094
Completed suicide 610.53 13.65 636 47905 241745 110299013
Immunodeficiency 575.34 13.65 299 48242 38539 110502219
Toxicity to various agents 561.12 13.65 858 47683 479697 110061061
Hyperhidrosis 547.62 13.65 533 48008 186765 110353993
Coeliac disease 493.61 13.65 280 48261 42907 110497851
Rash erythematous 348.11 13.65 288 48253 81544 110459214
Foetal death 346.99 13.65 160 48381 15885 110524873
Overdose 346.16 13.65 468 48073 233326 110307432
Fluid retention 342.25 13.65 303 48238 94004 110446754
Sedation 340.50 13.65 266 48275 69417 110471341
Upper respiratory tract infection 290.29 13.65 322 48219 131006 110409752
Nightmare 287.76 13.65 191 48350 38672 110502086
Bursitis 247.44 13.65 295 48246 129623 110411135
Drug hypersensitivity 224.40 13.65 565 47976 453525 110087233
Pneumonia aspiration 194.80 13.65 208 48333 81025 110459733
Back pain 184.59 13.65 463 48078 370533 110170225
Asthma 181.38 13.65 363 48178 249928 110290830
Nephrolithiasis 179.36 13.65 181 48360 66031 110474727
Prescribed overdose 178.55 13.65 206 48335 87375 110453383
Rheumatoid arthritis 165.07 13.65 389 48152 299224 110241534
Constipation 165.01 13.65 434 48107 357352 110183406
Neovascularisation 159.95 13.65 50 48491 1687 110539071
Treatment failure 154.94 13.65 362 48179 276872 110263886
Presbyacusis 147.40 13.65 53 48488 2766 110537992
Electrocardiogram QRS complex prolonged 136.88 13.65 80 48461 12941 110527817
Brugada syndrome 134.97 13.65 43 48498 1545 110539213
Psoriasis 132.68 13.65 228 48313 139765 110400993
Coma 132.00 13.65 207 48334 117662 110423096
Drug ineffective 129.36 13.65 1120 47421 1519420 109021338
Erythema 128.69 13.65 348 48193 291099 110249659
Pleural thickening 127.11 13.65 50 48491 3349 110537409
Pleural fibrosis 125.58 13.65 53 48488 4255 110536503
Somnolence 120.30 13.65 344 48197 297105 110243653
Intentional product misuse 120.14 13.65 212 48329 132692 110408066
Blood magnesium increased 118.04 13.65 49 48492 3774 110536984
Osteopenia 111.05 13.65 86 48455 22123 110518635
Hypersensitivity 107.35 13.65 405 48136 403593 110137165
Deafness neurosensory 106.16 13.65 61 48480 9558 110531200
Rubber sensitivity 102.63 13.65 39 48502 2379 110538379
Hepatic enzyme increased 99.12 13.65 338 48203 320554 110220204
Decreased immune responsiveness 98.29 13.65 58 48483 9548 110531210
Synovitis 96.45 13.65 6 48535 274086 110266672
Drug intolerance 93.85 13.65 390 48151 406122 110134636
Drug abuse 88.66 13.65 222 48319 177189 110363569
Drug ineffective for unapproved indication 86.48 13.65 159 48382 102679 110438079
Reversible airways obstruction 83.86 13.65 34 48507 2465 110538293
Vascular malformation 81.57 13.65 25 48516 789 110539969
Gastrooesophageal reflux disease 81.47 13.65 217 48324 179759 110360999
Epigastric discomfort 80.81 13.65 50 48491 8965 110531793
Paranasal cyst 78.98 13.65 25 48516 879 110539879
Headache 78.80 13.65 658 47883 881719 109659039
Paradoxical drug reaction 76.90 13.65 50 48491 9767 110530991
Neutropenia 75.46 13.65 35 48506 374585 110166173
Cervicogenic headache 75.33 13.65 18 48523 213 110540545
General physical health deterioration 75.05 13.65 47 48494 425248 110115510
Bone cyst 74.99 13.65 35 48506 3568 110537190
Pericarditis 73.61 13.65 6 48535 219108 110321650
Systemic lupus erythematosus 72.98 13.65 12 48529 254326 110286432
Myokymia 71.33 13.65 16 48525 140 110540618
Product used for unknown indication 70.34 13.65 28 48513 1935 110538823
Product use issue 70.29 13.65 297 48244 311398 110229360
Anaemia 69.21 13.65 83 48458 547003 109993755
Sensitivity to weather change 68.73 13.65 47 48494 9981 110530777
Contraindicated product administered 68.45 13.65 252 48289 248015 110292743
Febrile neutropenia 67.92 13.65 27 48514 316740 110224018
Glossodynia 67.09 13.65 9 48532 221995 110318763
Osteosclerosis 64.63 13.65 34 48507 4481 110536277
Cyst 63.78 13.65 55 48486 16441 110524317
Fatigue 62.84 13.65 811 47730 1215147 109325611
Mastoiditis 62.64 13.65 28 48513 2583 110538175
Cardio-respiratory arrest 62.15 13.65 149 48392 115687 110425071
Off label use 60.97 13.65 959 47582 1499226 109041532
Stomatitis 59.65 13.65 22 48519 270220 110270538
Wound 59.10 13.65 15 48526 234422 110306336
Pain 55.77 13.65 652 47889 954303 109586455
Somatic delusion 55.06 13.65 18 48523 703 110540055
Acute kidney injury 54.64 13.65 124 48417 635306 109905452
Pineal gland cyst 54.28 13.65 14 48527 231 110540527
Poor venous access 53.88 13.65 60 48481 24462 110516296
Suspected suicide 53.41 13.65 48 48493 15151 110525607
Lower respiratory tract infection 53.30 13.65 20 48521 243086 110297672
Pancytopenia 51.71 13.65 14 48527 209599 110331159
Suicidal ideation 51.65 13.65 122 48419 93815 110446943
Pneumonia 50.42 13.65 206 48335 876508 109664250
Swelling 50.22 13.65 48 48493 350993 110189765
Muscle injury 49.76 13.65 3 48538 140804 110399954
Helicobacter infection 49.11 13.65 10 48531 181867 110358891
Traumatic coma 46.07 13.65 10 48531 74 110540684
Extrapyramidal disorder 46.00 13.65 60 48481 28807 110511951
Serotonin syndrome 45.42 13.65 88 48453 59065 110481693
C-reactive protein abnormal 45.13 13.65 3 48538 129692 110411066
Liver disorder 44.85 13.65 5 48536 142238 110398520
Interstitial lung disease 43.67 13.65 5 48536 139329 110401429
Impaired healing 43.42 13.65 16 48525 196701 110344057
Arteriosclerosis coronary artery 42.84 13.65 54 48487 25064 110515694
Rheumatic fever 42.17 13.65 3 48538 122576 110418182
Vomiting 41.80 13.65 232 48309 910443 109630315
Deformity 41.58 13.65 35 48506 10125 110530633
Type 2 diabetes mellitus 41.58 13.65 13 48528 177219 110363539
Wheezing 41.27 13.65 31 48510 255199 110285559
Forced expiratory volume decreased 41.23 13.65 39 48502 13137 110527621
Rheumatoid factor positive 40.57 13.65 5 48536 131635 110409123
Ill-defined disorder 39.59 13.65 10 48531 156843 110383915
Product use in unapproved indication 39.44 13.65 333 48208 447044 110093714
Migraine 38.99 13.65 164 48377 171488 110369270
C-reactive protein increased 38.52 13.65 24 48517 217895 110322863
Migraine without aura 37.07 13.65 13 48528 630 110540128
Irritable bowel syndrome 36.85 13.65 13 48528 164202 110376556
Blood potassium increased 36.64 13.65 58 48483 33191 110507567
Disease progression 36.51 13.65 32 48509 244002 110296756
Anuria 36.33 13.65 49 48492 24292 110516466
Phonophobia 36.12 13.65 13 48528 680 110540078
Spinal stenosis 35.78 13.65 43 48498 19013 110521745
Nausea 35.58 13.65 749 47792 1234941 109305817
Accidental death 35.57 13.65 24 48517 4985 110535773
Hysterectomy 35.39 13.65 29 48512 8085 110532673
Sleep disorder due to general medical condition, insomnia type 35.18 13.65 3 48538 105640 110435118
Injury 34.99 13.65 17 48524 177248 110363510
Dyspnoea 34.65 13.65 315 48226 1106557 109434201
Dry eye 34.59 13.65 76 48465 55717 110485041
Oedema peripheral 34.41 13.65 57 48484 328603 110212155
Malignant neoplasm progression 34.06 13.65 17 48524 174550 110366208
Sepsis 34.06 13.65 57 48484 327289 110213469
Blister 33.79 13.65 30 48511 227346 110313412
Renal failure 33.55 13.65 30 48511 226544 110314214
Alopecia 33.11 13.65 69 48472 364684 110176074
Unresponsive to stimuli 33.07 13.65 81 48460 63709 110477049
Lip dry 32.90 13.65 3 48538 100080 110440678
Decreased appetite 32.46 13.65 104 48437 475742 110065016
Polymyositis 31.80 13.65 20 48521 3688 110537070
Hyperkalaemia 31.78 13.65 10 48531 135786 110404972
Confusional state 31.57 13.65 103 48438 468577 110072181
Poisoning 31.02 13.65 50 48491 29055 110511703
Atrial fibrillation 31.00 13.65 33 48508 229609 110311149
Bone density abnormal 30.87 13.65 20 48521 3883 110536875
Psoriatic arthropathy 30.41 13.65 25 48516 196736 110344022
Respiratory depression 30.12 13.65 52 48489 31949 110508809
Alanine aminotransferase increased 30.12 13.65 22 48519 183751 110357007
Inspiratory capacity decreased 30.09 13.65 17 48524 2578 110538180
Lung disorder 28.93 13.65 22 48519 180025 110360733
Drug dependence 28.62 13.65 66 48475 49954 110490804
Exposure during pregnancy 28.46 13.65 147 48394 167277 110373481
Retching 28.43 13.65 42 48499 22640 110518118
Night sweats 27.76 13.65 12 48529 133971 110406787
Aspartate aminotransferase increased 27.73 13.65 18 48523 159918 110380840
Vitamin B12 decreased 27.69 13.65 21 48520 5236 110535522
Gastrointestinal motility disorder 27.60 13.65 24 48517 7252 110533506
Ligamentum flavum hypertrophy 27.18 13.65 9 48532 366 110540392
Otitis media 27.04 13.65 24 48517 7452 110533306
Septic shock 26.95 13.65 18 48523 157510 110383248
Pleural effusion 26.95 13.65 23 48518 177686 110363072
Feelings of worthlessness 26.80 13.65 10 48531 580 110540178
Pulmonary fibrosis 26.74 13.65 6 48535 102036 110438722
Hypercholesterolaemia 26.69 13.65 4 48537 90833 110449925
Wound infection 26.67 13.65 5 48536 96460 110444298
Occult blood 26.63 13.65 14 48527 1842 110538916
Cervical dysplasia 26.61 13.65 16 48525 2724 110538034
Mucosal inflammation 26.55 13.65 5 48536 96136 110444622
Multiple organ dysfunction syndrome 26.41 13.65 17 48524 151693 110389065
Swollen joint count increased 26.22 13.65 3 48538 83658 110457100
Joint swelling 25.57 13.65 302 48239 442543 110098215
Hypoventilation 25.44 13.65 24 48517 8057 110532701
Oedema 25.31 13.65 33 48508 209943 110330815
Ascites 25.26 13.65 5 48536 92803 110447955
Skin lesion 25.12 13.65 64 48477 51567 110489191
Intentional overdose 25.12 13.65 120 48421 132381 110408377
Respiratory arrest 25.05 13.65 69 48472 58230 110482528
Disturbance in attention 24.32 13.65 71 48470 61924 110478834
Maternal exposure during pregnancy 24.16 13.65 47 48494 254836 110285922
Peripheral venous disease 24.04 13.65 4 48537 84113 110456645
Obsessive-compulsive disorder 23.75 13.65 22 48519 7219 110533539
Unmasking of previously unidentified disease 23.43 13.65 15 48526 2853 110537905
Major depression 23.35 13.65 26 48515 10595 110530163
Femoral neck fracture 23.01 13.65 28 48513 12539 110528219
Drug-induced liver injury 22.96 13.65 12 48529 120055 110420703
Carpal tunnel syndrome 22.95 13.65 38 48503 22572 110518186
Abnormal faeces 22.74 13.65 24 48517 9212 110531546
Craniofacial fracture 22.70 13.65 10 48531 891 110539867
Grip strength decreased 22.50 13.65 4 48537 80170 110460588
Blood cholesterol increased 22.31 13.65 29 48512 184756 110356002
Abdominal discomfort 22.28 13.65 93 48448 393765 110146993
Joint range of motion decreased 22.11 13.65 13 48528 121819 110418939
Infusion related reaction 22.02 13.65 260 48281 380902 110159856
Substance abuse 21.58 13.65 27 48514 12436 110528322
Heart rate increased 21.54 13.65 122 48419 143712 110397046
Urticaria 21.51 13.65 70 48471 318787 110221971
Impaired quality of life 21.05 13.65 43 48498 29974 110510784
Cytokine release syndrome 20.88 13.65 3 48538 70303 110470455
Epilepsy 20.72 13.65 9 48532 100200 110440558
Asthenia 20.67 13.65 198 48343 688801 109851957
Failed induction of labour 20.65 13.65 7 48534 306 110540452
Hypokalaemia 20.65 13.65 30 48511 182418 110358340
Live birth 20.55 13.65 3 48538 69481 110471277
Blood pressure abnormal 20.53 13.65 36 48505 22388 110518370
Hypertension 20.49 13.65 326 48215 509758 110031000
Neutrophil count decreased 20.44 13.65 14 48527 120927 110419831
Genital erosion 20.43 13.65 9 48532 802 110539956
Hepatitis 20.42 13.65 7 48534 90047 110450711
Pleural rub 20.42 13.65 5 48536 66 110540692
Oral discomfort 20.38 13.65 25 48516 11286 110529472
Gait inability 20.25 13.65 18 48523 136358 110404400
Vertebral lateral recess stenosis 19.85 13.65 7 48534 345 110540413
Hyperaesthesia 19.52 13.65 28 48513 14699 110526059
Osteoarthropathy 19.34 13.65 7 48534 372 110540386
Procedural pain 19.33 13.65 46 48495 35519 110505239
Obesity 19.32 13.65 13 48528 113338 110427420
International normalised ratio increased 19.24 13.65 7 48534 86765 110453993
Cardiac failure 19.20 13.65 33 48508 187593 110353165
Benzodiazepine drug level therapeutic 19.15 13.65 4 48537 24 110540734
Abulia 19.11 13.65 10 48531 1303 110539455
Alanine aminotransferase abnormal 19.08 13.65 22 48519 9312 110531446
Electrocardiogram repolarisation abnormality 18.55 13.65 12 48529 2323 110538435
Respiratory failure 18.48 13.65 42 48499 215290 110325468
Pruritus 18.35 13.65 165 48376 581395 109959363
Melaena 18.10 13.65 4 48537 68753 110472005
Hepatic failure 18.10 13.65 4 48537 68735 110472023
Gastrointestinal haemorrhage 17.98 13.65 28 48513 165490 110375268
Spinal osteoarthritis 17.96 13.65 32 48509 20151 110520607
Trigeminal neuralgia 17.82 13.65 15 48526 4337 110536421
Depressed mood 17.81 13.65 63 48478 60746 110480012
Post-traumatic stress disorder 17.79 13.65 18 48523 6578 110534180
Urine odour abnormal 17.78 13.65 19 48522 7396 110533362
Nasopharyngitis 17.74 13.65 101 48440 394260 110146498
Hepatic cirrhosis 17.67 13.65 4 48537 67622 110473136
Cardiac arrest 17.06 13.65 146 48395 196607 110344151
Ventricular tachyarrhythmia 17.02 13.65 7 48534 526 110540232
Postmortem blood drug level increased 16.95 13.65 9 48532 1208 110539550
Oesophageal irritation 16.95 13.65 6 48535 299 110540459
Binocular eye movement disorder 16.68 13.65 5 48536 146 110540612
Arthritis 16.67 13.65 30 48511 167556 110373202
Platelet count decreased 16.66 13.65 49 48492 230394 110310364
Viral pharyngitis 16.54 13.65 7 48534 566 110540192
Hypoglycaemia 16.44 13.65 16 48525 116088 110424670
Electrocardiogram ST segment elevation 16.11 13.65 20 48521 9140 110531618
Transaminases increased 16.07 13.65 4 48537 63386 110477372
Drug reaction with eosinophilia and systemic symptoms 16.00 13.65 8 48533 82087 110458671
Hypoxia 15.97 13.65 20 48521 129495 110411263
Dystonia 15.82 13.65 35 48506 25770 110514988
Colitis 15.81 13.65 13 48528 102310 110438448
Transcription medication error 15.62 13.65 7 48534 650 110540108
Toe operation 15.56 13.65 8 48533 1006 110539752
Inflammation 15.54 13.65 39 48502 193199 110347559
Multiple sclerosis relapse 15.54 13.65 53 48488 50187 110490571
Immune thrombocytopenia 15.51 13.65 32 48509 22462 110518296
Threatened labour 15.50 13.65 7 48534 661 110540097
Blood bilirubin increased 15.43 13.65 7 48534 75965 110464793
Rectal haemorrhage 15.31 13.65 18 48523 119815 110420943
Autoimmune disorder 15.00 13.65 5 48536 65478 110475280
Arthropathy 14.98 13.65 70 48471 287452 110253306
Pancreatitis acute 14.91 13.65 4 48537 60270 110480488
Bone hypertrophy 14.67 13.65 7 48534 750 110540008
Peripheral swelling 14.38 13.65 111 48430 403923 110136835
Shock 14.35 13.65 3 48538 53585 110487173
Hepatic function abnormal 14.23 13.65 11 48530 89284 110451474
Hyperglycaemia 14.18 13.65 10 48531 85080 110455678
Burning sensation 14.08 13.65 64 48477 69148 110471610
Sciatica 13.95 13.65 12 48529 92387 110448371
Haemoptysis 13.84 13.65 7 48534 71347 110469411
Lower limb fracture 13.73 13.65 8 48533 75340 110465418
Intentional product use issue 13.73 13.65 59 48482 247847 110292911

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Trismus 71.70 70.94 20 122 158 113653

Pharmacologic Action:

SourceCodeDescription
ATC N06AA10 NERVOUS SYSTEM
PSYCHOANALEPTICS
ANTIDEPRESSANTS
Non-selective monoamine reuptake inhibitors
MeSH PA D000928 Antidepressive Agents
MeSH PA D000929 Antidepressive Agents, Tricyclic
MeSH PA D011619 Psychotropic Drugs
MeSH PA D014179 Neurotransmitter Uptake Inhibitors
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018663 Adrenergic Agents
MeSH PA D018759 Adrenergic Uptake Inhibitors
MeSH PA D049990 Membrane Transport Modulators
FDA EPC N0000175752 Tricyclic Antidepressant
CHEBI has role CHEBI:35469 antidepressant
CHEBI has role CHEBI:35474 anxiolytic drug
CHEBI has role CHEBI:35476 antipsychotic agent
CHEBI has role CHEBI:35480 analgesic
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35640 adrenergic uptake inhibitor
CHEBI has role CHEBI:49103 drug metabolite
CHEBI has role CHEBI:50748 antipsoriatic
CHEBI has role CHEBI:53784 antispasmodic drug
CHEBI has role CHEBI:55324 gastrointestinal drug
CHEBI has role CHEBI:68495 apoptosis inducer
CHEBI has role CHEBI:50177 dermatologic drug
CHEBI has role CHEBI:176497 geroprotector

Related Drugs by ATC class:

N06AA Non-selective monoamine reuptake inhibitors 20 drugs
amineptineamitriptylineamoxapinebutriptylineclomipraminedesipraminedibenzepindimetacrinedosulepindoxepinimipramineimipramine oxide show all 20 →

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Depressive disorder indication 35489007
Neuropathic pain off-label use 247398009
Smoking cessation assistance off-label use 384742004
Attention deficit hyperactivity disorder off-label use 406506008
Suicidal thoughts contraindication 6471006
Alcoholism contraindication 7200002
Sinus tachycardia contraindication 11092001
Lowered convulsive threshold contraindication 19260006
Myocardial infarction contraindication 22298006 DOID:5844
Glaucoma contraindication 23986001 DOID:1686
Torsades de pointes contraindication 31722008
Hyperthyroidism contraindication 34486009 DOID:7998
Renal failure syndrome contraindication 42399005 DOID:1074
Conduction disorder of the heart contraindication 44808001
Hepatic failure contraindication 59927004
Open-angle glaucoma contraindication 84494001 DOID:1067
Epilepsy contraindication 84757009 DOID:1826
Prolonged QT interval contraindication 111975006
Seizure disorder contraindication 128613002
Bipolar affective disorder, current episode manic contraindication 191618007
Cerebrovascular accident contraindication 230690007
Benign prostatic hyperplasia contraindication 266569009
Retention of urine contraindication 267064002
Non-Q wave myocardial infarction contraindication 314207007
Breastfeeding (mother) contraindication 413712001
Myocardial infarction in recovery phase contraindication 418044006
Congenital long QT syndrome contraindication 442917000




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.5 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Sodium-dependent serotonin transporter Transporter INHIBITOR Ki 7.34 WOMBAT-PK CHEMBL
Sodium-dependent noradrenaline transporter Transporter INHIBITOR Kd 8.36 WOMBAT-PK CHEMBL
Aldehyde oxidase Enzyme IC50 6.07 WOMBAT-PK
D(1A) dopamine receptor GPCR Ki 6.57 DRUG MATRIX
D(2) dopamine receptor GPCR Ki 5.59 PDSP
Alpha-2A adrenergic receptor GPCR Ki 6.56 DRUG MATRIX
5-hydroxytryptamine receptor 1A GPCR Ki 6.51 WOMBAT-PK
5-hydroxytryptamine receptor 2A GPCR Ki 7.36 WOMBAT-PK
5-hydroxytryptamine receptor 2B GPCR Ki 7.07 DRUG MATRIX
5-hydroxytryptamine receptor 2C GPCR Ki 8 WOMBAT-PK
5-hydroxytryptamine receptor 6 GPCR Ki 6.67 CHEMBL
Alpha-1A adrenergic receptor GPCR Ki 7.26 WOMBAT-PK
Alpha-2B adrenergic receptor GPCR Ki 7 WOMBAT-PK
D(3) dopamine receptor GPCR Ki 7.22 DRUG MATRIX
Histamine H1 receptor GPCR Kd 8.03 WOMBAT-PK
Histamine H2 receptor GPCR Ki 5.64 DRUG MATRIX
Muscarinic acetylcholine receptor M1 GPCR Ki 7.40 WOMBAT-PK
Muscarinic acetylcholine receptor M2 GPCR Ki 6.96 WOMBAT-PK
Muscarinic acetylcholine receptor M3 GPCR Ki 7.30 WOMBAT-PK
Muscarinic acetylcholine receptor M4 GPCR Ki 7.08 WOMBAT-PK
Alpha-2C adrenergic receptor GPCR Ki 7.52 DRUG MATRIX
Sodium-dependent dopamine transporter Transporter Ki 5.92 PDSP
Alpha-1D adrenergic receptor GPCR Ki 6.91 DRUG MATRIX
Cytochrome P450 2C19 Enzyme IC50 5.52 DRUG MATRIX
Proto-oncogene tyrosine-protein kinase receptor Ret Kinase IC50 5.82 CHEMBL
Voltage-dependent N-type calcium channel subunit alpha-1B Ion channel IC50 5 CHEMBL
Cytochrome P450 2D6 Enzyme Km 6.23 WOMBAT-PK
ATP-sensitive inward rectifier potassium channel 10 Ion channel BLOCKER IC50 4.80 SCIENTIFIC LITERATURE
Muscarinic acetylcholine receptor M5 GPCR Ki 7.01 WOMBAT-PK
Alpha-1B adrenergic receptor GPCR Ki 6.94 DRUG MATRIX
5-hydroxytryptamine receptor 1B GPCR Ki 5.84 DRUG MATRIX
Alpha-1A adrenergic receptor GPCR IC50 10.40 CHEMBL
5-hydroxytryptamine receptor 1A GPCR IC50 5.73 CHEMBL
Histamine H1 receptor GPCR IC50 10.30 CHEMBL

External reference:

IDSource
4019860 VUID
N0000147946 NUI
D00816 KEGG_DRUG
894-71-3 SECONDARY_CAS_RN
4017520 VANDF
4019860 VANDF
C0028420 UMLSCUI
CHEBI:7640 CHEBI
21B PDB_CHEM_ID
CHEMBL445 ChEMBL_ID
DB00540 DRUGBANK_ID
CHEMBL1201156 ChEMBL_ID
D009661 MESH_DESCRIPTOR_UI
4543 PUBCHEM_CID
2404 IUPHAR_LIGAND_ID
1328 INN_ID
BL03SY4LXB UNII
203130 RXNORM
2733 MMSL
2740 MMSL
5192 MMSL
d00144 MMSL
001502 NDDF
004601 NDDF
13432000 SNOMEDCT_US
29666006 SNOMEDCT_US
372652004 SNOMEDCT_US
BL03SY4LXB INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Nortriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-0810 CAPSULE 10 mg ORAL ANDA 13 sections
Nortriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-0811 CAPSULE 25 mg ORAL ANDA 13 sections
Nortriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-0812 CAPSULE 50 mg ORAL ANDA 13 sections
Nortriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-0813 CAPSULE 75 mg ORAL ANDA 13 sections
Nortriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0121-0678 SOLUTION 10 mg ORAL ANDA 19 sections
PAMELOR HUMAN PRESCRIPTION DRUG LABEL 1 0406-9910 CAPSULE 10 mg ORAL NDA 19 sections
PAMELOR HUMAN PRESCRIPTION DRUG LABEL 1 0406-9911 CAPSULE 25 mg ORAL NDA 19 sections
PAMELOR HUMAN PRESCRIPTION DRUG LABEL 1 0406-9912 CAPSULE 50 mg ORAL NDA 19 sections
PAMELOR HUMAN PRESCRIPTION DRUG LABEL 1 0406-9913 CAPSULE 75 mg ORAL NDA 19 sections
Nortriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 10544-567 CAPSULE 10 mg ORAL ANDA 18 sections
NORTRIPTYLINE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 16590-171 CAPSULE 25 mg ORAL ANDA 16 sections
Nortriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 21695-093 CAPSULE 10 mg ORAL ANDA 13 sections
Nortriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 21695-094 CAPSULE 25 mg ORAL ANDA 13 sections
Nortriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 21695-599 CAPSULE 50 mg ORAL ANDA 13 sections
Nortriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 21695-600 CAPSULE 75 mg ORAL ANDA 13 sections
Nortriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 33261-348 CAPSULE 25 mg ORAL ANDA 18 sections
Nortriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 33261-532 CAPSULE 10 mg ORAL ANDA 18 sections
Nortriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 33261-692 CAPSULE 50 mg ORAL ANDA 18 sections
Nortriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 33261-804 CAPSULE 75 mg ORAL ANDA 18 sections
Nortriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 43063-722 CAPSULE 25 mg ORAL ANDA 18 sections
Nortriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 43063-722 CAPSULE 25 mg ORAL ANDA 18 sections
Nortriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 43063-897 CAPSULE 25 mg ORAL ANDA 19 sections
Nortriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 45865-371 CAPSULE 10 mg ORAL ANDA 18 sections
Nortriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 50090-0537 CAPSULE 10 mg ORAL ANDA 18 sections
Nortriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 50090-1322 CAPSULE 50 mg ORAL ANDA 13 sections
Nortriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 50090-7174 CAPSULE 10 mg ORAL ANDA 13 sections
Nortriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 50090-7191 CAPSULE 25 mg ORAL ANDA 19 sections
Nortriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 50436-4022 CAPSULE 25 mg ORAL ANDA 17 sections
Nortriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 50436-6652 CAPSULE 10 mg ORAL ANDA 18 sections
Nortriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 51655-507 CAPSULE 25 mg ORAL ANDA 19 sections