meclofenamic acid

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Property	Value	Reference
MRTD (Maximum Recommended Therapeutic Daily Dose)	19.30 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BDDCS (Biopharmaceutical Drug Disposition Classification System)	2	Hosey CM, Chan R, Benet LZ
BA (Bioavailability)	65.10 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Property	Description	Value	Unit	Confidence	Similarity
azlogd74	LogD at pH 7.4	2.259		High	1
caco2-efflux	Caco-2 efflux ratio (BA/AB)	0.538		High	1
caco2-intrinsic-papp	Caco-2 intrinsic apparent permeability	103.039	10^-6 cm/s	High	1
dh-clint	Dog hepatocyte intrinsic clearance	74.989	uL/min/10^6 cells	High	1
dppb	Dog plasma protein binding (% unbound)	0.240	%	High	1
fcs-ppb	Fetal calf serum protein binding (% unbound)	0.380	%	High	1
herg	hERG pIC50	4.328	pIC50	High	1
hh-clint	Human hepatocyte intrinsic clearance	179.473	uL/min/10^6 cells	High	1
hlm-clint	Human liver microsomal intrinsic clearance	90.991	uL/min/mg protein	High	1
hppb	Human plasma protein binding (% unbound)	0.250	%	High	1
kinase-safety-class	ACVR2A,ACVR2B,ACVRL1,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,GRK2,GSK3B,IKBKB,ITK,JAK1,JAK2,KIT,MAP2K6,MAP3K21,MAP3K7,MAPK14,MAPK7,MAPK9,MAPKAPK2,MTOR,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CB,PIK3CD,PIK3CG,PIM2,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ZAP70	50
kinase-selectivity-class	ACVR2A,ACVR2B,AXL,BRAF,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,GRK2,JAK1,MAP2K6,MAPK1,MAPK7,MTOR,PDK4,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK	24
mdck-mdr1-efflux	MDCK-MDR1 efflux ratio	2.805		High	1
mh-clint	Mouse hepatocyte intrinsic clearance	85.310		High	1
mppb	Mouse plasma protein binding (% unbound)	0.580		High	1
nih-mdck-mdr1-efflux	NIH MDCK-MDR1 efflux ratio	2.168		High	1
pfas-class	PFAS structural alert (1 = True, 0 = False)	0
pppb	Pig plasma protein binding (% unbound)	0.700	%	High	1
rh-clint	Rat hepatocyte intrinsic clearance	293.089	uL/min/10^6 cells	High	1
rh-fuinc	Rat hepatocyte fraction unbound in incubation	35.100	%	High	1
rppb	Rat plasma protein binding (% unbound)	0.140	%	High	1
solubility-dd	Solubility at pH 7.4 in DMSO	125.893	uM	High	1

Source	Code	Description
ATC	M01AG04	MUSCULO-SKELETAL SYSTEM ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS Fenamates
ATC	M02AA18	MUSCULO-SKELETAL SYSTEM TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN Antiinflammatory preparations, non-steroids for topical use
MeSH PA	D000700	Analgesics
MeSH PA	D000893	Anti-Inflammatory Agents
MeSH PA	D000894	Anti-Inflammatory Agents, Non-Steroidal
MeSH PA	D004791	Enzyme Inhibitors
MeSH PA	D016861	Cyclooxygenase Inhibitors
MeSH PA	D018501	Antirheumatic Agents
MeSH PA	D018689	Sensory System Agents
MeSH PA	D018712	Analgesics, Non-Narcotic
CHEBI has role	CHEBI:35475	non-steroidal anti-inflammatory drug
CHEBI has role	CHEBI:35480	analgesic
CHEBI has role	CHEBI:35493	antipyretic
CHEBI has role	CHEBI:35544	EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor
CHEBI has role	CHEBI:35610	antineoplastic agent
CHEBI has role	CHEBI:35623	anticonvulsant
CHEBI has role	CHEBI:35842	antirheumatic drug
CHEBI has role	CHEBI:64964	EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor

Disease	Relation	SNOMED_ID	DOID
Pain	indication	22253000
Rheumatoid arthritis	indication	69896004	DOID:7148
Dysmenorrhea	indication	266599000
Menorrhagia	indication	386692008
Osteoarthritis	indication	396275006
Ankylosing spondylitis	off-label use	9631008	DOID:7147
Vascular headache	off-label use	128187005
Alcoholism	contraindication	7200002
Peptic ulcer	contraindication	13200003	DOID:750
Myocardial infarction	contraindication	22298006	DOID:5844
Hypertensive disorder	contraindication	38341003	DOID:10763
Gastrointestinal ulcer	contraindication	40845000
Chronic heart failure	contraindication	48447003
Disorder of cardiovascular system	contraindication	49601007	DOID:1287
Gastrointestinal hemorrhage	contraindication	74474003
Kidney disease	contraindication	90708001	DOID:557
Liver function tests abnormal	contraindication	166603001
Coronary artery bypass graft	contraindication	232717009
Disease of liver	contraindication	235856003	DOID:409
Anemia	contraindication	271737000	DOID:2355
Peripheral edema	contraindication	271809000
Pregnancy, function	contraindication	289908002
Cardiovascular event risk	contraindication	395112001
Smokes tobacco daily	contraindication	449868002

Species	Use	Relation
Dogs	Chronic inflammatory disease involving the musculoskeletal system	Indication
Horses	Inflammatory diseases involving the musculoskeletal system	Indication

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meclofenamic acid 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Description:

Drug dosage:

ADMET properties:

Predicted pharmacokinetic/toxicological properties (PK-AZ):

Approvals:

FDA Adverse Event Reporting System (Female)

FDA Adverse Event Reporting System (Male)

FDA Adverse Event Reporting System (Geriatric)

FDA Adverse Event Reporting System (Pediatric)

Pharmacologic Action:

Related Drugs by ATC class:

Drug Use | Suggest Off label Use Form| |View source of the data|

🐶 Veterinary Drug Use

🐶 Veterinary products

Acid dissociation constants calculated using MoKa v3.0.0

Orange Book patent data (new drug applications)

Orange Book exclusivity data (new drug applications)

Bioactivity Summary:

External reference:

Pharmaceutical products:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source	MoA source
Arachidonate 5-lipoxygenase	Enzyme	P09917	LOX5_HUMAN	INHIBITOR	IC50	4.33	WOMBAT-PK	CHEMBL
Prostaglandin G/H synthase 1	Enzyme	P23219	PGH1_HUMAN	INHIBITOR	IC50	6.66	WOMBAT-PK	CHEMBL
Prostaglandin G/H synthase 2	Enzyme	P35354	PGH2_HUMAN	INHIBITOR	IC50	6.70	WOMBAT-PK	CHEMBL
Aldo-keto reductase family 1 member C1	Enzyme	Q04828	AK1C1_HUMAN		IC50	5.50	CHEMBL
Aldo-keto reductase family 1 member C2	Enzyme	P52895	AK1C2_HUMAN		IC50	5.06	CHEMBL
Aldo-keto reductase family 1 member C3	Enzyme	P42330	AK1C3_HUMAN		IC50	6.27	CHEMBL
Fatty acid-binding protein, intestinal	Cytosolic other	P12104	FABPI_HUMAN		Ki	5.05	CHEMBL
Transient receptor potential cation channel subfamily M member 4	Ion channel	Q8TD43	TRPM4_HUMAN	BLOCKER	IC50	5.47	IUPHAR
Mitogen-activated protein kinase 1	Kinase	P28482	MK01_HUMAN		IC50	5.50	DRUG MATRIX
Aldo-keto reductase family 1 member B10	Enzyme	O60218	AK1BA_HUMAN		IC50	5.01	CHEMBL
Nuclear receptor subfamily 4 group A member 1	Nuclear other	P22736	NR4A1_HUMAN		EC50	5.33	CHEMBL
Alpha-ketoglutarate-dependent dioxygenase FTO	Enzyme	Q9C0B1	FTO_HUMAN		IC50	5.10	CHEMBL
Transthyretin	Secreted	P02766	TTHY_HUMAN		IC50	4.30	CHEMBL
Androgen receptor	Nuclear hormone receptor	P10275	ANDR_HUMAN		IC50	4.19	WOMBAT-PK
Fatty acid-binding protein, liver	Cytosolic other		FABPL_RAT		Ki	6.59	CHEMBL
Prostaglandin G/H synthase 2	Enzyme		PGH2_MOUSE		IC50	6.70	CHEMBL
Prostaglandin G/H synthase 1	Enzyme		PGH1_SHEEP		IC50	7.30	CHEMBL
Arachidonate 5-lipoxygenase	Enzyme		LOX5_RAT		IC50	4.62	CHEMBL
Cyclooxygenase	Enzyme		PGH2_RAT PGH1_RAT		IC50	7	CHEMBL
Replicase polyprotein 1ab	Enzyme		R1AB_SARS2		Ki	4.30	CHEMBL

ID	Source
4019080	VUID
N0000147341	NUI
D00169	KEGG_DRUG
67254-91-5	SECONDARY_CAS_RN
4019079	VANDF
4019080	VANDF
4022843	VANDF
C0025042	UMLSCUI
CHEBI:6710	CHEBI
JMS	PDB_CHEM_ID
CHEMBL509	ChEMBL_ID
CHEMBL1562610	ChEMBL_ID
DB00939	DRUGBANK_ID
D008469	MESH_DESCRIPTOR_UI
4037	PUBCHEM_CID
7219	IUPHAR_LIGAND_ID
2165	INN_ID
48I5LU4ZWD	UNII
588003	RXNORM
1713	MMSL
5031	MMSL
d00283	MMSL
002387	NDDF
002388	NDDF
117178002	SNOMEDCT_US
58233009	SNOMEDCT_US
770315008	SNOMEDCT_US
96172003	SNOMEDCT_US
48I5LU4ZWD	INXIGHT DRUGS

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Meclofenamate Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	0378-2150	CAPSULE	50 mg	ORAL	ANDA	27 sections
Meclofenamate Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	0378-3000	CAPSULE	100 mg	ORAL	ANDA	27 sections

Product	Applicant	Ingredients
Arquel Granules	Zoetis Inc.	1
Arquel Tablets	Zoetis Inc.	1