losartan 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| angiotensin II receptor antagonists, antihypertensive (non-peptidic) | 1610 | 114798-26-4 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
An antagonist of ANGIOTENSIN TYPE 1 RECEPTOR with antihypertensive activity due to the reduced pressor effect of ANGIOTENSIN II.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 50 | mg | O |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Benet LZ, Broccatelli F, Oprea TI |
| S (Water solubility) | 0.05 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
| EoM (Fraction excreted unchanged in urine) | 12 % | Benet LZ, Broccatelli F, Oprea TI |
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 3.95 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
| BA (Bioavailability) | 35 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
| Vd (Volume of distribution) | 0.37 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 8.20 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| fu (Fraction unbound in plasma) | 0.01 % | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 1.80 hours | Lombardo F, Berellini G, Obach RS |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| April 14, 1995 | FDA | MERCK SHARP DOHME |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Pemphigus | 460.02 | 9.62 | 4 | 166732 | 183722 | 63138564 |
| Synovitis | 377.68 | 9.62 | 30 | 166706 | 186888 | 63135398 |
| Systemic lupus erythematosus | 365.59 | 9.62 | 56 | 166680 | 208862 | 63113424 |
| Hand deformity | 364.64 | 9.62 | 12 | 166724 | 159445 | 63162841 |
| Maternal exposure during pregnancy | 328.82 | 9.62 | 86 | 166650 | 219976 | 63102310 |
| Contraindicated product administered | 299.69 | 9.62 | 99 | 166637 | 217549 | 63104737 |
| Glossodynia | 284.75 | 9.62 | 61 | 166675 | 178815 | 63143471 |
| Wound | 259.19 | 9.62 | 56 | 166680 | 163207 | 63159079 |
| Drug intolerance | 244.66 | 9.62 | 270 | 166466 | 308391 | 63013895 |
| Infusion related reaction | 242.23 | 9.62 | 175 | 166561 | 245346 | 63076940 |
| Drug ineffective | 228.47 | 9.62 | 1710 | 165026 | 1043055 | 62279231 |
| Treatment failure | 222.24 | 9.62 | 123 | 166613 | 198920 | 63123366 |
| Arthropathy | 218.04 | 9.62 | 178 | 166558 | 234614 | 63087672 |
| Duodenal ulcer perforation | 213.18 | 9.62 | 3 | 166733 | 87206 | 63235080 |
| Cardiac failure congestive | 202.67 | 9.62 | 618 | 166118 | 91815 | 63230471 |
| Rheumatoid factor positive | 197.85 | 9.62 | 5 | 166731 | 84401 | 63237885 |
| Helicobacter infection | 173.82 | 9.62 | 20 | 166716 | 92765 | 63229521 |
| Pericarditis | 170.53 | 9.62 | 66 | 166670 | 131513 | 63190773 |
| Hepatic enzyme increased | 168.01 | 9.62 | 170 | 166566 | 202158 | 63120128 |
| Acute kidney injury | 167.63 | 9.62 | 1225 | 165511 | 262190 | 63060096 |
| Off label use | 159.41 | 9.62 | 1078 | 165658 | 673384 | 62648902 |
| Exposure during pregnancy | 158.43 | 9.62 | 107 | 166629 | 155440 | 63166846 |
| Folliculitis | 158.20 | 9.62 | 6 | 166730 | 70311 | 63251975 |
| Blood pressure increased | 157.91 | 9.62 | 841 | 165895 | 161221 | 63161065 |
| Therapeutic product effect decreased | 148.55 | 9.62 | 173 | 166563 | 193014 | 63129272 |
| Lower respiratory tract infection | 145.84 | 9.62 | 83 | 166653 | 132224 | 63190062 |
| Discomfort | 145.47 | 9.62 | 135 | 166601 | 167239 | 63155047 |
| Dizziness | 144.04 | 9.62 | 1743 | 164993 | 428182 | 62894104 |
| Joint swelling | 138.41 | 9.62 | 422 | 166314 | 327244 | 62995042 |
| Swelling | 130.85 | 9.62 | 335 | 166401 | 275043 | 63047243 |
| Muscle injury | 130.47 | 9.62 | 11 | 166725 | 65334 | 63256952 |
| Rheumatoid arthritis | 129.89 | 9.62 | 297 | 166439 | 253522 | 63068764 |
| Blood glucose increased | 128.32 | 9.62 | 497 | 166239 | 83259 | 63239027 |
| Hyponatraemia | 121.00 | 9.62 | 598 | 166138 | 111302 | 63210984 |
| Myocardial infarction | 119.00 | 9.62 | 549 | 166187 | 99344 | 63222942 |
| Sleep disorder due to general medical condition, insomnia type | 112.41 | 9.62 | 6 | 166730 | 52211 | 63270075 |
| Product substitution issue | 111.11 | 9.62 | 171 | 166565 | 15825 | 63306461 |
| Cough | 110.92 | 9.62 | 1216 | 165520 | 291527 | 63030759 |
| Diarrhoea | 106.36 | 9.62 | 2541 | 164195 | 712825 | 62609461 |
| Product use issue | 102.62 | 9.62 | 271 | 166465 | 220249 | 63102037 |
| Feeling abnormal | 95.90 | 9.62 | 693 | 166043 | 147699 | 63174587 |
| Drug abuse | 94.55 | 9.62 | 36 | 166700 | 72482 | 63249804 |
| Hypersensitivity | 93.97 | 9.62 | 422 | 166314 | 292263 | 63030023 |
| Blood pressure inadequately controlled | 92.89 | 9.62 | 88 | 166648 | 4890 | 63317396 |
| General physical health deterioration | 89.58 | 9.62 | 253 | 166483 | 201149 | 63121137 |
| Irritable bowel syndrome | 88.94 | 9.62 | 53 | 166683 | 82359 | 63239927 |
| Hyperkalaemia | 88.25 | 9.62 | 328 | 166408 | 53875 | 63268411 |
| Cerebrovascular accident | 85.12 | 9.62 | 530 | 166206 | 107494 | 63214792 |
| Product dose omission issue | 80.88 | 9.62 | 956 | 165780 | 233357 | 63088929 |
| Transient ischaemic attack | 78.59 | 9.62 | 248 | 166488 | 37505 | 63284781 |
| Impaired healing | 78.58 | 9.62 | 92 | 166644 | 102450 | 63219836 |
| Muscle spasms | 78.31 | 9.62 | 688 | 166048 | 155462 | 63166824 |
| Atrial fibrillation | 75.50 | 9.62 | 545 | 166191 | 116091 | 63206195 |
| Infection | 73.77 | 9.62 | 330 | 166406 | 228843 | 63093443 |
| Loss of employment | 73.75 | 9.62 | 55 | 166681 | 2189 | 63320097 |
| C-reactive protein increased | 72.54 | 9.62 | 85 | 166651 | 94622 | 63227664 |
| Febrile neutropenia | 70.40 | 9.62 | 127 | 166609 | 118322 | 63203964 |
| Malaise | 68.86 | 9.62 | 1501 | 165235 | 414453 | 62907833 |
| Abortion spontaneous | 65.70 | 9.62 | 21 | 166715 | 47174 | 63275112 |
| Blister | 65.44 | 9.62 | 153 | 166583 | 129661 | 63192625 |
| Acute myocardial infarction | 65.01 | 9.62 | 209 | 166527 | 31915 | 63290371 |
| Palpitations | 64.58 | 9.62 | 512 | 166224 | 112258 | 63210028 |
| COVID-19 | 63.95 | 9.62 | 512 | 166224 | 112591 | 63209695 |
| Cardiospasm | 63.25 | 9.62 | 47 | 166689 | 1860 | 63320426 |
| Chest pain | 62.53 | 9.62 | 853 | 165883 | 215106 | 63107180 |
| Anosmia | 61.82 | 9.62 | 83 | 166653 | 6777 | 63315509 |
| Pruritus genital | 61.50 | 9.62 | 53 | 166683 | 2601 | 63319685 |
| Palmoplantar keratoderma | 61.11 | 9.62 | 47 | 166689 | 1960 | 63320326 |
| Pregnancy | 59.72 | 9.62 | 12 | 166724 | 36824 | 63285462 |
| Fall | 59.66 | 9.62 | 1399 | 165337 | 390935 | 62931351 |
| Sleep terror | 59.04 | 9.62 | 52 | 166684 | 2628 | 63319658 |
| Dyspnoea | 59.02 | 9.62 | 2206 | 164530 | 659107 | 62663179 |
| Dry skin | 58.62 | 9.62 | 300 | 166436 | 56587 | 63265699 |
| Coronary artery disease | 56.99 | 9.62 | 201 | 166535 | 32176 | 63290110 |
| Vision blurred | 56.32 | 9.62 | 424 | 166312 | 91500 | 63230786 |
| Liver injury | 55.94 | 9.62 | 46 | 166690 | 60474 | 63261812 |
| Chronic kidney disease | 55.88 | 9.62 | 252 | 166484 | 45146 | 63277140 |
| Oligohydramnios | 55.81 | 9.62 | 76 | 166660 | 6290 | 63315996 |
| Tension headache | 54.97 | 9.62 | 68 | 166668 | 5118 | 63317168 |
| Alopecia | 54.90 | 9.62 | 594 | 166142 | 336942 | 62985344 |
| Pain | 54.87 | 9.62 | 1504 | 165232 | 739124 | 62583162 |
| Pyrexia | 53.95 | 9.62 | 890 | 165846 | 469588 | 62852698 |
| Musculoskeletal stiffness | 53.47 | 9.62 | 276 | 166460 | 184342 | 63137944 |
| Inappropriate antidiuretic hormone secretion | 52.84 | 9.62 | 122 | 166614 | 15340 | 63306946 |
| Hypertensive crisis | 52.66 | 9.62 | 121 | 166615 | 15165 | 63307121 |
| Bradycardia | 52.57 | 9.62 | 351 | 166385 | 72876 | 63249410 |
| Renal failure | 52.19 | 9.62 | 505 | 166231 | 117147 | 63205139 |
| Carotid artery occlusion | 52.11 | 9.62 | 63 | 166673 | 4631 | 63317655 |
| Myalgia | 51.45 | 9.62 | 600 | 166136 | 145929 | 63176357 |
| Fibromyalgia | 50.73 | 9.62 | 83 | 166653 | 80337 | 63241949 |
| Gastrointestinal disorder | 50.46 | 9.62 | 176 | 166560 | 131063 | 63191223 |
| Memory impairment | 49.99 | 9.62 | 455 | 166281 | 103803 | 63218483 |
| Blood creatinine increased | 49.83 | 9.62 | 398 | 166338 | 87446 | 63234840 |
| Lactic acidosis | 49.75 | 9.62 | 216 | 166520 | 38071 | 63284215 |
| Hip arthroplasty | 49.52 | 9.62 | 32 | 166704 | 47614 | 63274672 |
| Asthenia | 49.16 | 9.62 | 1337 | 165399 | 382267 | 62940019 |
| Intestinal angioedema | 49.06 | 9.62 | 27 | 166709 | 628 | 63321658 |
| Psoriasis | 48.25 | 9.62 | 392 | 166344 | 86565 | 63235721 |
| Product taste abnormal | 47.33 | 9.62 | 41 | 166695 | 2026 | 63320260 |
| Abdominal discomfort | 46.99 | 9.62 | 578 | 166158 | 320307 | 63001979 |
| Angioedema | 46.01 | 9.62 | 248 | 166488 | 47717 | 63274569 |
| Skin discolouration | 45.08 | 9.62 | 208 | 166528 | 37620 | 63284666 |
| Live birth | 44.48 | 9.62 | 7 | 166729 | 25623 | 63296663 |
| Toxicity to various agents | 44.35 | 9.62 | 425 | 166311 | 246825 | 63075461 |
| Malignant mediastinal neoplasm | 44.33 | 9.62 | 34 | 166702 | 1412 | 63320874 |
| Condition aggravated | 44.08 | 9.62 | 767 | 165969 | 401450 | 62920836 |
| Atrial tachycardia | 43.99 | 9.62 | 55 | 166681 | 4185 | 63318101 |
| Blood pressure abnormal | 42.46 | 9.62 | 111 | 166625 | 15087 | 63307199 |
| Body height decreased | 41.82 | 9.62 | 86 | 166650 | 9992 | 63312294 |
| Mobility decreased | 41.69 | 9.62 | 170 | 166566 | 120989 | 63201297 |
| Hypomagnesaemia | 41.14 | 9.62 | 167 | 166569 | 28570 | 63293716 |
| Ill-defined disorder | 40.68 | 9.62 | 97 | 166639 | 81658 | 63240628 |
| Therapeutic product effect incomplete | 40.25 | 9.62 | 180 | 166556 | 124876 | 63197410 |
| Dehydration | 39.38 | 9.62 | 657 | 166079 | 172697 | 63149589 |
| Product odour abnormal | 38.70 | 9.62 | 30 | 166706 | 1266 | 63321020 |
| Hypoglycaemia | 37.89 | 9.62 | 279 | 166457 | 59786 | 63262500 |
| Urinary tract infection | 37.79 | 9.62 | 936 | 165800 | 263748 | 63058538 |
| Eye pruritus | 37.35 | 9.62 | 121 | 166615 | 18550 | 63303736 |
| Cardiac disorder | 36.72 | 9.62 | 244 | 166492 | 50572 | 63271714 |
| Pain of skin | 36.72 | 9.62 | 89 | 166647 | 11545 | 63310741 |
| Therapy cessation | 36.68 | 9.62 | 168 | 166568 | 30289 | 63291997 |
| Hypotension | 35.69 | 9.62 | 953 | 165783 | 271651 | 63050635 |
| Anti-neutrophil cytoplasmic antibody positive vasculitis | 35.65 | 9.62 | 41 | 166695 | 2858 | 63319428 |
| Abdominal pain upper | 35.35 | 9.62 | 749 | 165987 | 205695 | 63116591 |
| Pancytopenia | 35.27 | 9.62 | 133 | 166603 | 96800 | 63225486 |
| Neutropenia | 34.78 | 9.62 | 293 | 166443 | 174712 | 63147574 |
| Immunisation | 34.29 | 9.62 | 27 | 166709 | 1166 | 63321120 |
| Oedema peripheral | 34.22 | 9.62 | 693 | 166043 | 188818 | 63133468 |
| Glycosylated haemoglobin increased | 34.08 | 9.62 | 90 | 166646 | 12308 | 63309978 |
| Subarachnoid haemorrhage | 33.64 | 9.62 | 98 | 166638 | 14185 | 63308101 |
| Visual impairment | 33.37 | 9.62 | 354 | 166382 | 84092 | 63238194 |
| Loss of personal independence in daily activities | 33.16 | 9.62 | 137 | 166599 | 97153 | 63225133 |
| Dermatitis atopic | 32.43 | 9.62 | 76 | 166660 | 9648 | 63312638 |
| Drug interaction | 32.31 | 9.62 | 809 | 165927 | 228322 | 63093964 |
| Myelosuppression | 32.19 | 9.62 | 11 | 166725 | 23692 | 63298594 |
| Type 2 diabetes mellitus | 31.59 | 9.62 | 76 | 166660 | 63792 | 63258494 |
| Rheumatoid nodule | 31.37 | 9.62 | 4 | 166732 | 17151 | 63305135 |
| Injury | 31.08 | 9.62 | 94 | 166642 | 73153 | 63249133 |
| Lip swelling | 30.74 | 9.62 | 162 | 166574 | 30901 | 63291385 |
| Multi-organ disorder | 30.66 | 9.62 | 28 | 166708 | 1484 | 63320802 |
| Device expulsion | 30.50 | 9.62 | 28 | 166708 | 34894 | 63287392 |
| Bone erosion | 30.38 | 9.62 | 5 | 166731 | 17712 | 63304574 |
| Pulmonary oedema | 30.23 | 9.62 | 247 | 166489 | 54626 | 63267660 |
| Blindness | 29.41 | 9.62 | 124 | 166612 | 21575 | 63300711 |
| Gastrointestinal haemorrhage | 29.19 | 9.62 | 334 | 166402 | 80842 | 63241444 |
| Red blood cell sedimentation rate increased | 29.06 | 9.62 | 44 | 166692 | 43938 | 63278348 |
| Renal impairment | 28.89 | 9.62 | 357 | 166379 | 87998 | 63234288 |
| Full blood count decreased | 28.75 | 9.62 | 140 | 166596 | 25884 | 63296402 |
| Intentional product use issue | 28.73 | 9.62 | 207 | 166529 | 127685 | 63194601 |
| Sprue-like enteropathy | 28.50 | 9.62 | 20 | 166716 | 723 | 63321563 |
| Malignant neoplasm progression | 28.39 | 9.62 | 115 | 166621 | 82006 | 63240280 |
| Asthmatic crisis | 28.16 | 9.62 | 29 | 166707 | 1784 | 63320502 |
| Hyperglycaemia | 27.86 | 9.62 | 197 | 166539 | 41670 | 63280616 |
| Hepatic steatosis | 27.76 | 9.62 | 149 | 166587 | 28620 | 63293666 |
| Drug tolerance decreased | 27.69 | 9.62 | 6 | 166730 | 17467 | 63304819 |
| Suspected suicide | 27.20 | 9.62 | 56 | 166680 | 6512 | 63315774 |
| Leukopenia | 26.86 | 9.62 | 108 | 166628 | 77182 | 63245104 |
| Eye haemorrhage | 26.82 | 9.62 | 65 | 166671 | 8431 | 63313855 |
| Syncope | 26.68 | 9.62 | 445 | 166291 | 116940 | 63205346 |
| Flatulence | 26.52 | 9.62 | 169 | 166567 | 34533 | 63287753 |
| International normalised ratio increased | 26.13 | 9.62 | 210 | 166526 | 46215 | 63276071 |
| Cardiac failure | 26.12 | 9.62 | 353 | 166383 | 88789 | 63233497 |
| CD30 expression | 26.02 | 9.62 | 8 | 166728 | 36 | 63322250 |
| Dysgeusia | 25.59 | 9.62 | 210 | 166526 | 46500 | 63275786 |
| Hypoparathyroidism | 25.42 | 9.62 | 18 | 166718 | 660 | 63321626 |
| Ventricular tachycardia | 25.41 | 9.62 | 112 | 166624 | 19867 | 63302419 |
| Suicide attempt | 25.26 | 9.62 | 79 | 166657 | 60839 | 63261447 |
| Neuropathy peripheral | 25.14 | 9.62 | 429 | 166307 | 113238 | 63209048 |
| Glomerular filtration rate decreased | 25.00 | 9.62 | 85 | 166651 | 13356 | 63308930 |
| Bundle branch block left | 24.45 | 9.62 | 56 | 166680 | 7003 | 63315283 |
| Pruritus | 24.45 | 9.62 | 1172 | 165564 | 360281 | 62962005 |
| Hallucination | 24.15 | 9.62 | 235 | 166501 | 54582 | 63267704 |
| Knee arthroplasty | 24.13 | 9.62 | 68 | 166668 | 54138 | 63268148 |
| Haemorrhagic stroke | 23.54 | 9.62 | 49 | 166687 | 5743 | 63316543 |
| Mitral valve incompetence | 23.54 | 9.62 | 108 | 166628 | 19486 | 63302800 |
| Dysphonia | 23.42 | 9.62 | 209 | 166527 | 47405 | 63274881 |
| Glomerulonephritis rapidly progressive | 23.32 | 9.62 | 20 | 166716 | 975 | 63321311 |
| Primary hyperaldosteronism | 23.19 | 9.62 | 8 | 166728 | 55 | 63322231 |
| Back pain | 23.14 | 9.62 | 880 | 165856 | 263265 | 63059021 |
| Eye pain | 22.94 | 9.62 | 160 | 166576 | 33694 | 63288592 |
| Body temperature increased | 22.88 | 9.62 | 39 | 166697 | 37153 | 63285133 |
| Psoriatic arthropathy | 22.61 | 9.62 | 144 | 166592 | 91376 | 63230910 |
| Blood immunoglobulin E increased | 22.43 | 9.62 | 38 | 166698 | 3811 | 63318475 |
| Cutaneous T-cell dyscrasia | 22.37 | 9.62 | 8 | 166728 | 62 | 63322224 |
| Eye irritation | 22.02 | 9.62 | 115 | 166621 | 21856 | 63300430 |
| Intentional self-injury | 21.96 | 9.62 | 21 | 166715 | 25666 | 63296620 |
| Renal disorder | 21.85 | 9.62 | 155 | 166581 | 32819 | 63289467 |
| Facet joint syndrome | 21.79 | 9.62 | 3 | 166733 | 12135 | 63310151 |
| Nasopharyngitis | 21.75 | 9.62 | 505 | 166231 | 253752 | 63068534 |
| Papillary muscle rupture | 21.27 | 9.62 | 5 | 166731 | 5 | 63322281 |
| Insomnia | 21.27 | 9.62 | 727 | 166009 | 214525 | 63107761 |
| Blood glucose decreased | 21.23 | 9.62 | 110 | 166626 | 20842 | 63301444 |
| Blood pressure diastolic abnormal | 21.09 | 9.62 | 6 | 166730 | 14536 | 63307750 |
| Sedation | 20.97 | 9.62 | 44 | 166692 | 38765 | 63283521 |
| Blood potassium decreased | 20.94 | 9.62 | 185 | 166551 | 41841 | 63280445 |
| Diabetes mellitus inadequate control | 20.93 | 9.62 | 87 | 166649 | 15039 | 63307247 |
| Hepatotoxicity | 20.86 | 9.62 | 41 | 166695 | 37000 | 63285286 |
| Thyroid disorder | 20.82 | 9.62 | 87 | 166649 | 15075 | 63307211 |
| Drug hypersensitivity | 20.59 | 9.62 | 640 | 166096 | 310047 | 63012239 |
| Overweight | 20.51 | 9.62 | 36 | 166700 | 3715 | 63318571 |
| Tinnitus | 20.51 | 9.62 | 162 | 166574 | 35466 | 63286820 |
| Blood urea increased | 20.49 | 9.62 | 129 | 166607 | 26250 | 63296036 |
| Mouth swelling | 20.32 | 9.62 | 41 | 166695 | 4699 | 63317587 |
| Diplopia | 20.31 | 9.62 | 119 | 166617 | 23609 | 63298677 |
| Nausea | 20.13 | 9.62 | 2549 | 164187 | 851922 | 62470364 |
| Product quality issue | 20.05 | 9.62 | 162 | 166574 | 35703 | 63286583 |
| Noninfectious peritonitis | 20.03 | 9.62 | 9 | 166727 | 133 | 63322153 |
| Sodium retention | 20.03 | 9.62 | 9 | 166727 | 133 | 63322153 |
| Dopamine transporter scintigraphy abnormal | 19.99 | 9.62 | 8 | 166728 | 87 | 63322199 |
| Balance disorder | 19.90 | 9.62 | 322 | 166414 | 84100 | 63238186 |
| Oral pain | 19.71 | 9.62 | 135 | 166601 | 28259 | 63294027 |
| Muscle spasticity | 19.60 | 9.62 | 17 | 166719 | 21777 | 63300509 |
| Nervousness | 19.59 | 9.62 | 144 | 166592 | 30835 | 63291451 |
| Sialoadenitis | 19.48 | 9.62 | 23 | 166713 | 1649 | 63320637 |
| Ischaemic cardiomyopathy | 19.38 | 9.62 | 28 | 166708 | 2449 | 63319837 |
| Hyperlipidaemia | 19.31 | 9.62 | 102 | 166634 | 19469 | 63302817 |
| Facial pain | 18.96 | 9.62 | 66 | 166670 | 10495 | 63311791 |
| Hypertensive emergency | 18.87 | 9.62 | 24 | 166712 | 1858 | 63320428 |
| Anuria | 18.81 | 9.62 | 74 | 166662 | 12477 | 63309809 |
| Vasculitis | 18.73 | 9.62 | 96 | 166640 | 18113 | 63304173 |
| Bone marrow failure | 18.68 | 9.62 | 30 | 166706 | 29260 | 63293026 |
| Vitamin B6 deficiency | 18.65 | 9.62 | 8 | 166728 | 105 | 63322181 |
| Blood pressure systolic abnormal | 18.55 | 9.62 | 6 | 166730 | 13380 | 63308906 |
| Diabetes mellitus | 18.46 | 9.62 | 226 | 166510 | 55584 | 63266702 |
| Ageusia | 18.25 | 9.62 | 78 | 166658 | 13650 | 63308636 |
| Disability | 18.16 | 9.62 | 13 | 166723 | 18334 | 63303952 |
| Milk-alkali syndrome | 18.11 | 9.62 | 16 | 166720 | 812 | 63321474 |
| Bromhidrosis | 18.09 | 9.62 | 5 | 166731 | 14 | 63322272 |
| Product residue present | 17.76 | 9.62 | 35 | 166701 | 3944 | 63318342 |
| Premature baby | 17.67 | 9.62 | 17 | 166719 | 20718 | 63301568 |
| Haemorrhage intracranial | 17.65 | 9.62 | 76 | 166660 | 13343 | 63308943 |
| Myeloma cast nephropathy | 17.58 | 9.62 | 8 | 166728 | 122 | 63322164 |
| Scleroderma renal crisis | 17.52 | 9.62 | 11 | 166725 | 329 | 63321957 |
| Gait disturbance | 17.42 | 9.62 | 616 | 166120 | 182562 | 63139724 |
| Prescribed overdose | 17.40 | 9.62 | 40 | 166696 | 34113 | 63288173 |
| Rhinorrhoea | 17.33 | 9.62 | 255 | 166481 | 65322 | 63256964 |
| Disease progression | 17.22 | 9.62 | 223 | 166513 | 122535 | 63199751 |
| Venous occlusion | 17.13 | 9.62 | 16 | 166720 | 873 | 63321413 |
| Coma | 17.09 | 9.62 | 99 | 166637 | 64265 | 63258021 |
| Dengue fever | 17.07 | 9.62 | 14 | 166722 | 641 | 63321645 |
| Muscle twitching | 17.07 | 9.62 | 99 | 166637 | 19569 | 63302717 |
| Diabetic foot | 17.02 | 9.62 | 20 | 166716 | 1427 | 63320859 |
| Angina unstable | 17.01 | 9.62 | 49 | 166687 | 7046 | 63315240 |
| Diabetic ketoacidosis | 17.01 | 9.62 | 102 | 166634 | 20403 | 63301883 |
| Rash papular | 17.01 | 9.62 | 84 | 166652 | 15618 | 63306668 |
| Gastritis | 16.96 | 9.62 | 161 | 166575 | 37142 | 63285144 |
| Blood phosphorus increased | 16.96 | 9.62 | 30 | 166706 | 3115 | 63319171 |
| Vascular stenosis | 16.94 | 9.62 | 11 | 166725 | 349 | 63321937 |
| Cytomegalovirus infection | 16.92 | 9.62 | 18 | 166718 | 20934 | 63301352 |
| Nodular rash | 16.89 | 9.62 | 9 | 166727 | 196 | 63322090 |
| Blood pressure diastolic decreased | 16.72 | 9.62 | 21 | 166715 | 22685 | 63299601 |
| Injection site reaction | 16.64 | 9.62 | 88 | 166648 | 58436 | 63263850 |
| Tremor | 16.62 | 9.62 | 460 | 166276 | 131779 | 63190507 |
| Atrioventricular block | 16.62 | 9.62 | 51 | 166685 | 7596 | 63314690 |
| Near death experience | 16.60 | 9.62 | 12 | 166724 | 455 | 63321831 |
| Influenza | 16.24 | 9.62 | 387 | 166349 | 108335 | 63213951 |
| Swollen tongue | 16.22 | 9.62 | 151 | 166585 | 34649 | 63287637 |
| Headache | 16.17 | 9.62 | 1899 | 164837 | 631342 | 62690944 |
| Thymus disorder | 16.17 | 9.62 | 10 | 166726 | 291 | 63321995 |
| Thrombosis | 16.02 | 9.62 | 249 | 166487 | 64506 | 63257780 |
| Grip strength decreased | 16.01 | 9.62 | 21 | 166715 | 22266 | 63300020 |
| Stomatitis | 15.97 | 9.62 | 262 | 166474 | 138463 | 63183823 |
| Panniculitis | 15.96 | 9.62 | 5 | 166731 | 11380 | 63310906 |
| Urine albumin/creatinine ratio increased | 15.93 | 9.62 | 10 | 166726 | 299 | 63321987 |
| Electrocardiogram PR prolongation | 15.85 | 9.62 | 14 | 166722 | 710 | 63321576 |
| Premature delivery | 15.81 | 9.62 | 35 | 166701 | 30246 | 63292040 |
| Neuroleptic malignant syndrome | 15.68 | 9.62 | 6 | 166730 | 12050 | 63310236 |
| Spinal epidural haematoma | 15.68 | 9.62 | 17 | 166719 | 1110 | 63321176 |
| Blindness transient | 15.60 | 9.62 | 32 | 166704 | 3712 | 63318574 |
| Poisoning deliberate | 15.60 | 9.62 | 5 | 166731 | 11213 | 63311073 |
| Arrhythmia | 15.59 | 9.62 | 161 | 166575 | 37979 | 63284307 |
| Pulmonary toxicity | 15.49 | 9.62 | 3 | 166733 | 9452 | 63312834 |
| Pseudolymphoma | 15.47 | 9.62 | 13 | 166723 | 616 | 63321670 |
| Cardiorenal syndrome | 15.44 | 9.62 | 15 | 166721 | 860 | 63321426 |
| Renin decreased | 15.42 | 9.62 | 7 | 166729 | 106 | 63322180 |
| Hypokalaemia | 15.35 | 9.62 | 369 | 166367 | 103435 | 63218851 |
| Linear IgA disease | 15.34 | 9.62 | 19 | 166717 | 1432 | 63320854 |
| Blood pressure decreased | 15.32 | 9.62 | 248 | 166488 | 64774 | 63257512 |
| Blood magnesium decreased | 15.30 | 9.62 | 72 | 166664 | 13126 | 63309160 |
| Angina pectoris | 15.30 | 9.62 | 133 | 166603 | 29945 | 63292341 |
| Hyperhidrosis | 15.25 | 9.62 | 381 | 166355 | 107455 | 63214831 |
| Sinusitis | 15.22 | 9.62 | 466 | 166270 | 226187 | 63096099 |
| Norepinephrine increased | 15.18 | 9.62 | 6 | 166730 | 63 | 63322223 |
| Gout | 15.10 | 9.62 | 72 | 166664 | 13199 | 63309087 |
| Drug resistance | 15.09 | 9.62 | 23 | 166713 | 22910 | 63299376 |
| Foetal exposure during pregnancy | 15.05 | 9.62 | 39 | 166697 | 31923 | 63290363 |
| Diabetic retinopathy | 14.94 | 9.62 | 24 | 166712 | 2303 | 63319983 |
| Nasal congestion | 14.94 | 9.62 | 249 | 166487 | 65411 | 63256875 |
| Pain in extremity | 14.89 | 9.62 | 1036 | 165700 | 330450 | 62991836 |
| Lacrimation increased | 14.86 | 9.62 | 99 | 166637 | 20532 | 63301754 |
| Anaphylactic reaction | 14.83 | 9.62 | 107 | 166629 | 65993 | 63256293 |
| Eosinophilia myalgia syndrome | 14.80 | 9.62 | 4 | 166732 | 10 | 63322276 |
| Dystonia | 14.75 | 9.62 | 9 | 166727 | 13810 | 63308476 |
| Ascites | 14.73 | 9.62 | 56 | 166680 | 40672 | 63281614 |
| Choking | 14.61 | 9.62 | 58 | 166678 | 9821 | 63312465 |
| Haemophagocytic lymphohistiocytosis | 14.31 | 9.62 | 5 | 166731 | 10622 | 63311664 |
| Extradural haematoma | 14.26 | 9.62 | 20 | 166716 | 1702 | 63320584 |
| Joint range of motion decreased | 14.20 | 9.62 | 41 | 166695 | 32387 | 63289899 |
| Product dispensing error | 14.05 | 9.62 | 59 | 166677 | 10246 | 63312040 |
| Colitis microscopic | 13.95 | 9.62 | 55 | 166681 | 9284 | 63313002 |
| Upper gastrointestinal haemorrhage | 13.91 | 9.62 | 91 | 166645 | 18761 | 63303525 |
| Drug dependence | 13.87 | 9.62 | 27 | 166709 | 24456 | 63297830 |
| Blood sodium decreased | 13.81 | 9.62 | 110 | 166626 | 24142 | 63298144 |
| Otolithiasis | 13.80 | 9.62 | 4 | 166732 | 14 | 63322272 |
| Cholecystitis chronic | 13.74 | 9.62 | 5 | 166731 | 10356 | 63311930 |
| Dislocation of vertebra | 13.61 | 9.62 | 3 | 166733 | 8632 | 63313654 |
| Autoimmune disorder | 13.60 | 9.62 | 15 | 166721 | 17162 | 63305124 |
| Arrhythmia supraventricular | 13.58 | 9.62 | 15 | 166721 | 1000 | 63321286 |
| Acute myeloid leukaemia | 13.55 | 9.62 | 15 | 166721 | 17132 | 63305154 |
| Premature labour | 13.54 | 9.62 | 8 | 166728 | 12496 | 63309790 |
| Gastric disorder | 13.54 | 9.62 | 154 | 166582 | 37215 | 63285071 |
| Haemoglobin decreased | 13.52 | 9.62 | 488 | 166248 | 144997 | 63177289 |
| Recalled product administered | 13.22 | 9.62 | 11 | 166725 | 514 | 63321772 |
| Instillation site pain | 13.22 | 9.62 | 14 | 166722 | 890 | 63321396 |
| Rash | 13.20 | 9.62 | 1281 | 165455 | 559590 | 62762696 |
| Mucosal inflammation | 13.10 | 9.62 | 71 | 166665 | 46857 | 63275429 |
| Product packaging issue | 13.08 | 9.62 | 16 | 166720 | 1190 | 63321096 |
| Crystal urine | 13.05 | 9.62 | 5 | 166731 | 48 | 63322238 |
| Left ventricular hypertrophy | 13.03 | 9.62 | 37 | 166699 | 5278 | 63317008 |
| Overdose | 13.03 | 9.62 | 218 | 166518 | 114860 | 63207426 |
| Normal newborn | 12.94 | 9.62 | 3 | 166733 | 8338 | 63313948 |
| Hepatic failure | 12.91 | 9.62 | 49 | 166687 | 35607 | 63286679 |
| Eyelid pain | 12.88 | 9.62 | 9 | 166727 | 323 | 63321963 |
| Cardiac valve disease | 12.86 | 9.62 | 32 | 166704 | 4220 | 63318066 |
| Inflammation | 12.85 | 9.62 | 146 | 166590 | 82127 | 63240159 |
| Faeces discoloured | 12.84 | 9.62 | 88 | 166648 | 18421 | 63303865 |
| Haematoma | 12.84 | 9.62 | 144 | 166592 | 34676 | 63287610 |
| Head injury | 12.83 | 9.62 | 119 | 166617 | 27277 | 63295009 |
| Spider naevus | 12.83 | 9.62 | 7 | 166729 | 160 | 63322126 |
| Fear | 12.81 | 9.62 | 78 | 166658 | 15688 | 63306598 |
| Amenorrhoea | 12.79 | 9.62 | 5 | 166731 | 9909 | 63312377 |
| Rebound tachycardia | 12.76 | 9.62 | 3 | 166733 | 3 | 63322283 |
| Suicidal ideation | 12.62 | 9.62 | 104 | 166632 | 62317 | 63259969 |
| Product physical issue | 12.53 | 9.62 | 35 | 166701 | 4945 | 63317341 |
| Calciphylaxis | 12.50 | 9.62 | 26 | 166710 | 3046 | 63319240 |
| Pollakiuria | 12.42 | 9.62 | 120 | 166616 | 27817 | 63294469 |
| Leukaemoid reaction | 12.23 | 9.62 | 7 | 166729 | 176 | 63322110 |
| Ulcer | 12.18 | 9.62 | 32 | 166704 | 26075 | 63296211 |
| Patella fracture | 12.12 | 9.62 | 21 | 166715 | 2145 | 63320141 |
| Creatinine renal clearance decreased | 12.09 | 9.62 | 15 | 166721 | 16293 | 63305993 |
| Blindness unilateral | 12.08 | 9.62 | 40 | 166696 | 6201 | 63316085 |
| Swelling face | 12.07 | 9.62 | 234 | 166502 | 63241 | 63259045 |
| Poor quality product administered | 12.01 | 9.62 | 26 | 166710 | 3130 | 63319156 |
| Epilepsy | 12.01 | 9.62 | 34 | 166702 | 27031 | 63295255 |
| Cardiovascular disorder | 11.96 | 9.62 | 62 | 166674 | 11750 | 63310536 |
| Chromaturia | 11.91 | 9.62 | 80 | 166656 | 16637 | 63305649 |
| Decreased immune responsiveness | 11.90 | 9.62 | 34 | 166702 | 4867 | 63317419 |
| Chikungunya virus infection | 11.89 | 9.62 | 7 | 166729 | 186 | 63322100 |
| Hypoacusis | 11.87 | 9.62 | 106 | 166630 | 24045 | 63298241 |
| Sinus bradycardia | 11.83 | 9.62 | 72 | 166664 | 14479 | 63307807 |
| Suspiciousness | 11.81 | 9.62 | 9 | 166727 | 370 | 63321916 |
| Pancreatitis acute | 11.74 | 9.62 | 116 | 166620 | 27050 | 63295236 |
| Hiccups | 11.67 | 9.62 | 21 | 166715 | 2210 | 63320076 |
| Psychotic disorder | 11.63 | 9.62 | 32 | 166704 | 25680 | 63296606 |
| Device dislocation | 11.62 | 9.62 | 32 | 166704 | 25673 | 63296613 |
| Obstructive airways disorder | 11.58 | 9.62 | 23 | 166713 | 20676 | 63301610 |
| Blood aldosterone increased | 11.56 | 9.62 | 7 | 166729 | 196 | 63322090 |
| Haemorrhagic fever | 11.55 | 9.62 | 3 | 166733 | 6 | 63322280 |
| Transplant rejection | 11.53 | 9.62 | 7 | 166729 | 10773 | 63311513 |
| Myopathy | 11.51 | 9.62 | 59 | 166677 | 11132 | 63311154 |
| Device difficult to use | 11.49 | 9.62 | 10 | 166726 | 12786 | 63309500 |
| Agitation | 11.43 | 9.62 | 101 | 166635 | 59656 | 63262630 |
| Gastroenteritis aeromonas | 11.42 | 9.62 | 4 | 166732 | 29 | 63322257 |
| Blood glucose abnormal | 11.40 | 9.62 | 46 | 166690 | 7846 | 63314440 |
| Aortic stenosis | 11.40 | 9.62 | 34 | 166702 | 4986 | 63317300 |
| Hypertensive encephalopathy | 11.38 | 9.62 | 11 | 166725 | 627 | 63321659 |
| Blood cholesterol increased | 11.35 | 9.62 | 176 | 166560 | 93856 | 63228430 |
| Renal artery stenosis | 11.33 | 9.62 | 19 | 166717 | 1890 | 63320396 |
| End stage renal disease | 11.30 | 9.62 | 41 | 166695 | 6652 | 63315634 |
| Neutropenic sepsis | 11.29 | 9.62 | 16 | 166720 | 16422 | 63305864 |
| Bone pain | 11.28 | 9.62 | 204 | 166532 | 54437 | 63267849 |
| Familial periodic paralysis | 11.24 | 9.62 | 5 | 166731 | 72 | 63322214 |
| Nail bed tenderness | 11.21 | 9.62 | 9 | 166727 | 400 | 63321886 |
| Weight decreased | 11.05 | 9.62 | 857 | 165879 | 275941 | 63046345 |
| Weight increased | 11.02 | 9.62 | 566 | 166170 | 260226 | 63062060 |
| Arteriosclerosis | 11.01 | 9.62 | 54 | 166682 | 10012 | 63312274 |
| Blood parathyroid hormone decreased | 10.98 | 9.62 | 6 | 166730 | 9785 | 63312501 |
| Night sweats | 10.96 | 9.62 | 79 | 166657 | 48735 | 63273551 |
| Pneumonia aspiration | 10.93 | 9.62 | 50 | 166686 | 34490 | 63287796 |
| Affect lability | 10.91 | 9.62 | 8 | 166728 | 11143 | 63311143 |
| Ultrasound kidney abnormal | 10.86 | 9.62 | 4 | 166732 | 34 | 63322252 |
| Poisoning | 10.81 | 9.62 | 12 | 166724 | 13688 | 63308598 |
| Hypovolaemia | 10.79 | 9.62 | 56 | 166680 | 10617 | 63311669 |
| Laboratory test abnormal | 10.71 | 9.62 | 113 | 166623 | 26799 | 63295487 |
| Hypertension | 10.70 | 9.62 | 862 | 165874 | 278441 | 63043845 |
| Lip dry | 10.68 | 9.62 | 15 | 166721 | 15455 | 63306831 |
| Inferior vena cava dilatation | 10.66 | 9.62 | 5 | 166731 | 82 | 63322204 |
| Thrombocytopenia | 10.58 | 9.62 | 309 | 166427 | 150848 | 63171438 |
| Aspergillus infection | 10.57 | 9.62 | 4 | 166732 | 8089 | 63314197 |
| Infective pulmonary exacerbation of cystic fibrosis | 10.49 | 9.62 | 5 | 166731 | 8812 | 63313474 |
| Dysstasia | 10.45 | 9.62 | 93 | 166643 | 21073 | 63301213 |
| Hypersensitivity vasculitis | 10.45 | 9.62 | 29 | 166707 | 4083 | 63318203 |
| Sluggishness | 10.40 | 9.62 | 34 | 166702 | 5235 | 63317051 |
| Foreign body sensation in eyes | 10.40 | 9.62 | 20 | 166716 | 2214 | 63320072 |
| Blood loss anaemia | 10.36 | 9.62 | 49 | 166687 | 8952 | 63313334 |
| Caesarean section | 10.35 | 9.62 | 18 | 166718 | 17014 | 63305272 |
| Human herpesvirus 6 encephalitis | 10.30 | 9.62 | 7 | 166729 | 240 | 63322046 |
| Accelerated hypertension | 10.30 | 9.62 | 9 | 166727 | 450 | 63321836 |
| Heart rate increased | 10.25 | 9.62 | 322 | 166414 | 93916 | 63228370 |
| Heart valve calcification | 10.24 | 9.62 | 3 | 166733 | 11 | 63322275 |
| Mitral valve stenosis | 10.24 | 9.62 | 14 | 166722 | 1163 | 63321123 |
| Hypophosphataemia | 10.23 | 9.62 | 58 | 166678 | 11368 | 63310918 |
| Suffocation feeling | 10.18 | 9.62 | 15 | 166721 | 1335 | 63320951 |
| Thrombocytosis | 10.13 | 9.62 | 36 | 166700 | 5782 | 63316504 |
| Food allergy | 10.13 | 9.62 | 9 | 166727 | 11392 | 63310894 |
| Diabetic metabolic decompensation | 10.12 | 9.62 | 17 | 166719 | 1693 | 63320593 |
| Bronchopulmonary aspergillosis | 10.12 | 9.62 | 5 | 166731 | 8630 | 63313656 |
| Septic shock | 10.11 | 9.62 | 119 | 166617 | 66510 | 63255776 |
| Therapeutic response decreased | 10.08 | 9.62 | 108 | 166628 | 61417 | 63260869 |
| Pulmonary hypertension | 10.06 | 9.62 | 145 | 166591 | 36978 | 63285308 |
| Eructation | 10.06 | 9.62 | 46 | 166690 | 8287 | 63313999 |
| Carotid bruit | 10.02 | 9.62 | 11 | 166725 | 728 | 63321558 |
| Iron deficiency anaemia | 10.00 | 9.62 | 88 | 166648 | 19881 | 63302405 |
| Hypocalcaemia | 9.87 | 9.62 | 127 | 166609 | 31586 | 63290700 |
| Uterine perforation | 9.86 | 9.62 | 3 | 166733 | 6960 | 63315326 |
| Nail infection | 9.85 | 9.62 | 21 | 166715 | 2502 | 63319784 |
| Drug monitoring procedure not performed | 9.81 | 9.62 | 10 | 166726 | 608 | 63321678 |
| Eye swelling | 9.79 | 9.62 | 101 | 166635 | 23817 | 63298469 |
| Periorbital oedema | 9.75 | 9.62 | 35 | 166701 | 5649 | 63316637 |
| Depressed mood | 9.73 | 9.62 | 154 | 166582 | 40037 | 63282249 |
| Cardiotoxicity | 9.72 | 9.62 | 5 | 166731 | 8433 | 63313853 |
| Hiatus hernia | 9.72 | 9.62 | 93 | 166643 | 21501 | 63300785 |
| Platelet count decreased | 9.71 | 9.62 | 385 | 166351 | 115737 | 63206549 |
| Therapy interrupted | 9.70 | 9.62 | 129 | 166607 | 32326 | 63289960 |
| Atrial septal defect | 9.68 | 9.62 | 40 | 166696 | 6898 | 63315388 |
| Lower limb fracture | 9.63 | 9.62 | 32 | 166704 | 24189 | 63298097 |
| Chronic obstructive pulmonary disease | 9.62 | 9.62 | 224 | 166512 | 62462 | 63259824 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Angioedema | 195.75 | 10.28 | 383 | 106137 | 36991 | 34813420 |
| Drug abuse | 189.73 | 10.28 | 36 | 106484 | 99060 | 34751351 |
| Febrile neutropenia | 119.18 | 10.28 | 145 | 106375 | 136704 | 34713707 |
| Toxicity to various agents | 115.14 | 10.28 | 277 | 106243 | 200085 | 34650326 |
| Cardiospasm | 111.31 | 10.28 | 66 | 106454 | 1522 | 34848889 |
| Dizziness | 105.12 | 10.28 | 1072 | 105448 | 217449 | 34632962 |
| Off label use | 103.53 | 10.28 | 802 | 105718 | 418722 | 34431689 |
| Neutropenia | 97.12 | 10.28 | 208 | 106312 | 156570 | 34693841 |
| Palmoplantar keratoderma | 96.37 | 10.28 | 65 | 106455 | 1888 | 34848523 |
| Myocardial infarction | 95.53 | 10.28 | 664 | 105856 | 120421 | 34729990 |
| Tension headache | 91.10 | 10.28 | 75 | 106445 | 2967 | 34847444 |
| Pruritus genital | 89.28 | 10.28 | 65 | 106455 | 2139 | 34848272 |
| Sleep terror | 88.57 | 10.28 | 66 | 106454 | 2252 | 34848159 |
| Carotid artery occlusion | 79.67 | 10.28 | 76 | 106444 | 3661 | 34846750 |
| Anosmia | 78.60 | 10.28 | 78 | 106442 | 3946 | 34846465 |
| Cardiac failure congestive | 77.43 | 10.28 | 476 | 106044 | 82794 | 34767617 |
| Immunisation | 76.11 | 10.28 | 45 | 106475 | 1032 | 34849379 |
| Atrial tachycardia | 73.70 | 10.28 | 72 | 106448 | 3573 | 34846838 |
| Foetal exposure during pregnancy | 70.45 | 10.28 | 15 | 106505 | 38086 | 34812325 |
| Facial pain | 69.04 | 10.28 | 70 | 106450 | 3634 | 34846777 |
| Hyperkalaemia | 68.55 | 10.28 | 403 | 106117 | 68986 | 34781425 |
| Drug ineffective | 68.47 | 10.28 | 981 | 105539 | 455770 | 34394641 |
| Fatigue | 68.36 | 10.28 | 1542 | 104978 | 369111 | 34481300 |
| General physical health deterioration | 67.68 | 10.28 | 185 | 106335 | 128084 | 34722327 |
| Eye pruritus | 67.66 | 10.28 | 98 | 106422 | 7391 | 34843020 |
| Transient ischaemic attack | 67.20 | 10.28 | 211 | 106309 | 27402 | 34823009 |
| Psoriasis | 64.76 | 10.28 | 262 | 106258 | 38550 | 34811861 |
| Leukopenia | 63.14 | 10.28 | 59 | 106461 | 62797 | 34787614 |
| Blood glucose increased | 63.02 | 10.28 | 383 | 106137 | 66335 | 34784076 |
| Palpitations | 62.84 | 10.28 | 265 | 106255 | 39721 | 34810690 |
| Acute myocardial infarction | 61.71 | 10.28 | 325 | 106195 | 53394 | 34797017 |
| Suicide attempt | 58.40 | 10.28 | 23 | 106497 | 39093 | 34811318 |
| Peripheral swelling | 57.53 | 10.28 | 415 | 106105 | 76126 | 34774285 |
| Feeling abnormal | 51.11 | 10.28 | 349 | 106171 | 62886 | 34787525 |
| Myalgia | 49.98 | 10.28 | 432 | 106088 | 83678 | 34766733 |
| Thrombocytopenia | 49.27 | 10.28 | 277 | 106243 | 155970 | 34694441 |
| Tinnitus | 48.28 | 10.28 | 153 | 106367 | 19965 | 34830446 |
| Pruritus | 47.05 | 10.28 | 649 | 105871 | 141332 | 34709079 |
| Pain of skin | 46.76 | 10.28 | 74 | 106446 | 6035 | 34844376 |
| Angina unstable | 46.56 | 10.28 | 107 | 106413 | 11546 | 34838865 |
| Visual impairment | 46.31 | 10.28 | 224 | 106296 | 35578 | 34814833 |
| Lip swelling | 45.88 | 10.28 | 130 | 106390 | 15950 | 34834461 |
| Sprue-like enteropathy | 45.87 | 10.28 | 25 | 106495 | 488 | 34849923 |
| Blindness | 44.57 | 10.28 | 123 | 106397 | 14863 | 34835548 |
| Overdose | 43.88 | 10.28 | 137 | 106383 | 90922 | 34759489 |
| Abdominal discomfort | 43.56 | 10.28 | 322 | 106198 | 59513 | 34790898 |
| Blood pressure increased | 43.06 | 10.28 | 434 | 106086 | 87668 | 34762743 |
| Product substitution issue | 42.91 | 10.28 | 95 | 106425 | 10000 | 34840411 |
| Pericarditis | 41.21 | 10.28 | 102 | 106418 | 11543 | 34838868 |
| Treatment failure | 41.10 | 10.28 | 49 | 106471 | 46648 | 34803763 |
| Serotonin syndrome | 40.86 | 10.28 | 6 | 106514 | 19927 | 34830484 |
| Cerebrovascular accident | 39.64 | 10.28 | 414 | 106106 | 84397 | 34766014 |
| Pyrexia | 39.57 | 10.28 | 746 | 105774 | 332267 | 34518144 |
| Intentional overdose | 39.33 | 10.28 | 45 | 106475 | 43629 | 34806782 |
| Dry skin | 39.21 | 10.28 | 194 | 106326 | 31093 | 34819318 |
| Coma | 39.07 | 10.28 | 49 | 106471 | 45629 | 34804782 |
| Hypertensive emergency | 38.37 | 10.28 | 29 | 106491 | 1011 | 34849400 |
| Multiple organ dysfunction syndrome | 37.73 | 10.28 | 114 | 106406 | 76452 | 34773959 |
| Product dose omission issue | 37.54 | 10.28 | 542 | 105978 | 119169 | 34731242 |
| Cytomegalovirus infection | 36.40 | 10.28 | 17 | 106503 | 26118 | 34824293 |
| Rash papular | 36.34 | 10.28 | 90 | 106430 | 10188 | 34840223 |
| Muscle twitching | 36.22 | 10.28 | 90 | 106430 | 10208 | 34840203 |
| Muscular weakness | 36.04 | 10.28 | 360 | 106160 | 72537 | 34777874 |
| Plasmapheresis | 34.93 | 10.28 | 18 | 106502 | 312 | 34850099 |
| Ventricular tachycardia | 34.88 | 10.28 | 167 | 106353 | 26412 | 34823999 |
| Atrial fibrillation | 34.45 | 10.28 | 544 | 105976 | 121849 | 34728562 |
| Condition aggravated | 34.08 | 10.28 | 398 | 106122 | 191798 | 34658613 |
| Pancytopenia | 33.73 | 10.28 | 162 | 106358 | 94995 | 34755416 |
| Malignant neoplasm progression | 33.53 | 10.28 | 146 | 106374 | 87900 | 34762511 |
| Septic shock | 32.57 | 10.28 | 111 | 106409 | 71723 | 34778688 |
| Mucosal inflammation | 31.42 | 10.28 | 43 | 106477 | 38579 | 34811832 |
| Coronary artery disease | 31.28 | 10.28 | 253 | 106267 | 48052 | 34802359 |
| Amnesia | 30.00 | 10.28 | 160 | 106360 | 26403 | 34824008 |
| Drug dispensed to wrong patient | 29.65 | 10.28 | 19 | 106501 | 505 | 34849906 |
| Dyspnoea | 29.41 | 10.28 | 1416 | 105104 | 375366 | 34475045 |
| Hypertensive crisis | 29.24 | 10.28 | 75 | 106445 | 8676 | 34841735 |
| Memory impairment | 29.21 | 10.28 | 229 | 106291 | 43089 | 34807322 |
| Hepatic cytolysis | 28.29 | 10.28 | 5 | 106515 | 14491 | 34835920 |
| Disease progression | 28.18 | 10.28 | 203 | 106317 | 107874 | 34742537 |
| Neuroleptic malignant syndrome | 27.67 | 10.28 | 10 | 106510 | 17924 | 34832487 |
| COVID-19 | 27.51 | 10.28 | 359 | 106161 | 77191 | 34773220 |
| Cardiac disorder | 25.85 | 10.28 | 222 | 106298 | 42904 | 34807507 |
| Intestinal angioedema | 25.83 | 10.28 | 13 | 106507 | 214 | 34850197 |
| C-reactive protein increased | 25.62 | 10.28 | 82 | 106438 | 54016 | 34796395 |
| Epilepsy | 25.58 | 10.28 | 17 | 106503 | 21478 | 34828933 |
| Diarrhoea | 25.10 | 10.28 | 1439 | 105081 | 388473 | 34461938 |
| Back pain | 24.63 | 10.28 | 514 | 106006 | 121275 | 34729136 |
| Ascites | 23.91 | 10.28 | 68 | 106452 | 46503 | 34803908 |
| Vasculitis | 23.61 | 10.28 | 82 | 106438 | 11214 | 34839197 |
| Syncope | 23.32 | 10.28 | 400 | 106120 | 91051 | 34759360 |
| Therapeutic product effect incomplete | 22.97 | 10.28 | 78 | 106442 | 50463 | 34799948 |
| Drug dependence | 22.85 | 10.28 | 24 | 106496 | 24193 | 34826218 |
| Chest pain | 22.77 | 10.28 | 526 | 105994 | 126236 | 34724175 |
| Premature baby | 22.73 | 10.28 | 16 | 106504 | 19617 | 34830794 |
| Infusion related reaction | 22.70 | 10.28 | 84 | 106436 | 52973 | 34797438 |
| Cough | 22.52 | 10.28 | 608 | 105912 | 149532 | 34700879 |
| Subarachnoid haemorrhage | 22.44 | 10.28 | 87 | 106433 | 12548 | 34837863 |
| Cytokine release syndrome | 22.35 | 10.28 | 22 | 106498 | 22855 | 34827556 |
| Acute kidney injury | 22.25 | 10.28 | 1139 | 105381 | 303849 | 34546562 |
| Respiratory depression | 21.96 | 10.28 | 11 | 106509 | 16234 | 34834177 |
| Sedation | 21.94 | 10.28 | 19 | 106501 | 20987 | 34829424 |
| Alanine aminotransferase increased | 21.94 | 10.28 | 150 | 106370 | 80665 | 34769746 |
| Diabetic neuropathy | 21.94 | 10.28 | 43 | 106477 | 4154 | 34846257 |
| Status epilepticus | 21.30 | 10.28 | 6 | 106514 | 12608 | 34837803 |
| Product use in unapproved indication | 20.92 | 10.28 | 243 | 106277 | 117256 | 34733155 |
| Rash | 20.81 | 10.28 | 853 | 105667 | 221899 | 34628512 |
| Diplopia | 20.79 | 10.28 | 104 | 106416 | 16739 | 34833672 |
| Paraesthesia | 20.67 | 10.28 | 292 | 106228 | 63880 | 34786531 |
| Delirium | 20.60 | 10.28 | 67 | 106453 | 43924 | 34806487 |
| Skin discolouration | 20.50 | 10.28 | 108 | 106412 | 17737 | 34832674 |
| Chronic kidney disease | 20.11 | 10.28 | 203 | 106317 | 41007 | 34809404 |
| Cholestasis | 19.97 | 10.28 | 32 | 106488 | 26916 | 34823495 |
| Migraine | 19.55 | 10.28 | 105 | 106415 | 17373 | 34833038 |
| Paraplegia | 19.23 | 10.28 | 33 | 106487 | 2878 | 34847533 |
| Pathogen resistance | 19.10 | 10.28 | 3 | 106517 | 9479 | 34840932 |
| Blood pressure inadequately controlled | 18.87 | 10.28 | 31 | 106489 | 2609 | 34847802 |
| Bone marrow failure | 18.75 | 10.28 | 38 | 106482 | 29215 | 34821196 |
| Dengue fever | 18.73 | 10.28 | 11 | 106509 | 249 | 34850162 |
| Hallucination | 18.50 | 10.28 | 239 | 106281 | 51259 | 34799152 |
| Contraindicated product administered | 18.41 | 10.28 | 23 | 106497 | 21458 | 34828953 |
| Posterior reversible encephalopathy syndrome | 18.23 | 10.28 | 4 | 106516 | 9950 | 34840461 |
| Carcinogenicity | 18.15 | 10.28 | 7 | 106513 | 58 | 34850353 |
| Adverse drug reaction | 18.09 | 10.28 | 152 | 106368 | 29190 | 34821221 |
| Neurotoxicity | 17.96 | 10.28 | 17 | 106503 | 17993 | 34832418 |
| Abdominal pain upper | 17.61 | 10.28 | 311 | 106209 | 71179 | 34779232 |
| Product quality issue | 17.49 | 10.28 | 100 | 106420 | 16935 | 34833476 |
| Acute respiratory distress syndrome | 17.28 | 10.28 | 33 | 106487 | 25936 | 34824475 |
| Tenosynovitis stenosans | 17.10 | 10.28 | 5 | 106515 | 15 | 34850396 |
| Gamma-glutamyltransferase increased | 17.06 | 10.28 | 40 | 106480 | 29191 | 34821220 |
| C-reactive protein abnormal | 17.00 | 10.28 | 3 | 106517 | 8707 | 34841704 |
| Schizophrenia | 16.88 | 10.28 | 3 | 106517 | 8663 | 34841748 |
| Alopecia | 16.55 | 10.28 | 129 | 106391 | 24226 | 34826185 |
| High frequency ablation | 16.54 | 10.28 | 9 | 106511 | 175 | 34850236 |
| Abdominal wall haematoma | 16.54 | 10.28 | 24 | 106496 | 1813 | 34848598 |
| Transient aphasia | 16.53 | 10.28 | 12 | 106508 | 393 | 34850018 |
| Balance disorder | 16.47 | 10.28 | 193 | 106327 | 40461 | 34809950 |
| Blood creatinine increased | 16.40 | 10.28 | 392 | 106128 | 94584 | 34755827 |
| Cognitive disorder | 16.31 | 10.28 | 146 | 106374 | 28547 | 34821864 |
| Muscle spasms | 16.29 | 10.28 | 320 | 106200 | 74681 | 34775730 |
| Hyperthermia | 16.15 | 10.28 | 6 | 106514 | 10571 | 34839840 |
| Vitamin B1 deficiency | 16.05 | 10.28 | 11 | 106509 | 328 | 34850083 |
| Eosinophilia | 16.02 | 10.28 | 35 | 106485 | 26187 | 34824224 |
| Dermatitis atopic | 16.01 | 10.28 | 44 | 106476 | 5303 | 34845108 |
| Peri-implantitis | 15.99 | 10.28 | 8 | 106512 | 130 | 34850281 |
| Aspartate aminotransferase increased | 15.93 | 10.28 | 131 | 106389 | 67652 | 34782759 |
| Gastroenteritis eosinophilic | 15.72 | 10.28 | 9 | 106511 | 194 | 34850217 |
| Depressed level of consciousness | 15.72 | 10.28 | 72 | 106448 | 42769 | 34807642 |
| Febrile bone marrow aplasia | 15.65 | 10.28 | 3 | 106517 | 8206 | 34842205 |
| Pneumonia aspiration | 15.63 | 10.28 | 70 | 106450 | 41833 | 34808578 |
| Haematotoxicity | 15.61 | 10.28 | 3 | 106517 | 8191 | 34842220 |
| Antineutrophil cytoplasmic antibody increased | 15.44 | 10.28 | 5 | 106515 | 23 | 34850388 |
| Miosis | 15.26 | 10.28 | 5 | 106515 | 9530 | 34840881 |
| Headache | 15.15 | 10.28 | 752 | 105768 | 199883 | 34650528 |
| Sepsis | 15.13 | 10.28 | 389 | 106131 | 166172 | 34684239 |
| Vascular injury | 15.12 | 10.28 | 10 | 106510 | 281 | 34850130 |
| Product odour abnormal | 15.08 | 10.28 | 15 | 106505 | 761 | 34849650 |
| Obstructive airways disorder | 15.02 | 10.28 | 15 | 106505 | 15479 | 34834932 |
| Hepatocellular injury | 14.98 | 10.28 | 28 | 106492 | 22183 | 34828228 |
| Cardiac flutter | 14.95 | 10.28 | 23 | 106497 | 1830 | 34848581 |
| Abdominal pain | 14.90 | 10.28 | 382 | 106138 | 163236 | 34687175 |
| Psychotic disorder | 14.64 | 10.28 | 33 | 106487 | 24419 | 34825992 |
| Burning feet syndrome | 14.61 | 10.28 | 7 | 106513 | 103 | 34850308 |
| Aggression | 14.58 | 10.28 | 65 | 106455 | 38899 | 34811512 |
| Heart rate increased | 14.57 | 10.28 | 210 | 106310 | 46133 | 34804278 |
| Insomnia | 14.50 | 10.28 | 417 | 106103 | 103490 | 34746921 |
| Synovitis | 14.36 | 10.28 | 13 | 106507 | 14053 | 34836358 |
| Hyponatraemic seizure | 14.07 | 10.28 | 6 | 106514 | 66 | 34850345 |
| Diabetic foot | 13.89 | 10.28 | 28 | 106492 | 2760 | 34847651 |
| Respiratory failure | 13.84 | 10.28 | 240 | 106280 | 108332 | 34742079 |
| Coeliac disease | 13.82 | 10.28 | 14 | 106506 | 726 | 34849685 |
| Chikungunya virus infection | 13.46 | 10.28 | 5 | 106515 | 37 | 34850374 |
| Guillain-Barre syndrome | 13.44 | 10.28 | 45 | 106475 | 6042 | 34844369 |
| Blister | 13.35 | 10.28 | 117 | 106403 | 22741 | 34827670 |
| Shoshin beriberi | 13.32 | 10.28 | 6 | 106514 | 76 | 34850335 |
| Pneumocystis jirovecii pneumonia | 13.15 | 10.28 | 25 | 106495 | 19685 | 34830726 |
| Toxic epidermal necrolysis | 13.14 | 10.28 | 29 | 106491 | 21617 | 34828794 |
| Neutrophil count increased | 13.05 | 10.28 | 20 | 106500 | 17126 | 34833285 |
| Blood pressure abnormal | 12.94 | 10.28 | 54 | 106466 | 8052 | 34842359 |
| Asthenia | 12.92 | 10.28 | 890 | 105630 | 244361 | 34606050 |
| Eczema nummular | 12.92 | 10.28 | 7 | 106513 | 135 | 34850276 |
| Agranulocytosis | 12.81 | 10.28 | 34 | 106486 | 23787 | 34826624 |
| Renal pain | 12.80 | 10.28 | 29 | 106491 | 3099 | 34847312 |
| Hepatic function abnormal | 12.71 | 10.28 | 81 | 106439 | 44282 | 34806129 |
| Seizure | 12.66 | 10.28 | 234 | 106286 | 104623 | 34745788 |
| Progressive multifocal leukoencephalopathy | 12.63 | 10.28 | 7 | 106513 | 9757 | 34840654 |
| Blood pressure diastolic decreased | 12.53 | 10.28 | 6 | 106514 | 9088 | 34841323 |
| Blood glucose decreased | 12.49 | 10.28 | 76 | 106444 | 13161 | 34837250 |
| Fluid retention | 12.42 | 10.28 | 131 | 106389 | 26756 | 34823655 |
| Heat stroke | 12.38 | 10.28 | 15 | 106505 | 950 | 34849461 |
| Dystonia | 12.34 | 10.28 | 9 | 106511 | 10836 | 34839575 |
| B-cell small lymphocytic lymphoma stage IV | 12.32 | 10.28 | 3 | 106517 | 3 | 34850408 |
| Dysphonia | 12.29 | 10.28 | 117 | 106403 | 23266 | 34827145 |
| Ageusia | 12.26 | 10.28 | 63 | 106457 | 10245 | 34840166 |
| Application site haematoma | 12.24 | 10.28 | 5 | 106515 | 49 | 34850362 |
| Tendon rupture | 12.22 | 10.28 | 48 | 106472 | 6964 | 34843447 |
| Epstein-Barr virus infection | 12.21 | 10.28 | 4 | 106516 | 7624 | 34842787 |
| Plasma cell myeloma refractory | 12.16 | 10.28 | 12 | 106508 | 603 | 34849808 |
| Exposure during pregnancy | 12.15 | 10.28 | 6 | 106514 | 8928 | 34841483 |
| Neoplasm progression | 11.97 | 10.28 | 34 | 106486 | 23266 | 34827145 |
| Oral mucosal blistering | 11.83 | 10.28 | 21 | 106499 | 1881 | 34848530 |
| Atheroembolism | 11.73 | 10.28 | 9 | 106511 | 321 | 34850090 |
| Akathisia | 11.72 | 10.28 | 5 | 106515 | 8104 | 34842307 |
| Anhidrosis | 11.70 | 10.28 | 6 | 106514 | 103 | 34850308 |
| Ichthyosis | 11.59 | 10.28 | 6 | 106514 | 105 | 34850306 |
| Diffuse large B-cell lymphoma | 11.56 | 10.28 | 4 | 106516 | 7366 | 34843045 |
| Recalled product administered | 11.53 | 10.28 | 11 | 106509 | 530 | 34849881 |
| Food allergy | 11.35 | 10.28 | 18 | 106502 | 1470 | 34848941 |
| Granulocytopenia | 11.32 | 10.28 | 3 | 106517 | 6564 | 34843847 |
| Dysgeusia | 11.27 | 10.28 | 127 | 106393 | 26370 | 34824041 |
| Osteoarthritis | 11.20 | 10.28 | 104 | 106416 | 20538 | 34829873 |
| Product use issue | 11.14 | 10.28 | 131 | 106389 | 63085 | 34787326 |
| Cachexia | 11.10 | 10.28 | 4 | 106516 | 7182 | 34843229 |
| Blood osmolarity decreased | 11.03 | 10.28 | 11 | 106509 | 560 | 34849851 |
| Eye irritation | 11.02 | 10.28 | 49 | 106471 | 7512 | 34842899 |
| Carotid bruit | 10.99 | 10.28 | 7 | 106513 | 184 | 34850227 |
| Rash maculo-papular | 10.93 | 10.28 | 47 | 106473 | 28404 | 34822007 |
| Hypogammaglobulinaemia | 10.83 | 10.28 | 5 | 106515 | 7735 | 34842676 |
| Renal disorder | 10.79 | 10.28 | 122 | 106398 | 25358 | 34825053 |
| Haemorrhagic stroke | 10.79 | 10.28 | 44 | 106476 | 6495 | 34843916 |
| Hyphaema | 10.77 | 10.28 | 11 | 106509 | 576 | 34849835 |
| Coordination abnormal | 10.74 | 10.28 | 49 | 106471 | 7595 | 34842816 |
| Lymphopenia | 10.66 | 10.28 | 21 | 106499 | 16314 | 34834097 |
| Non-cardiac chest pain | 10.60 | 10.28 | 33 | 106487 | 4264 | 34846147 |
| Drug resistance | 10.47 | 10.28 | 42 | 106478 | 25885 | 34824526 |
| Cataract | 10.47 | 10.28 | 124 | 106396 | 26062 | 34824349 |
| Lichen planus | 10.41 | 10.28 | 14 | 106506 | 985 | 34849426 |
| Infection | 10.33 | 10.28 | 205 | 106315 | 90710 | 34759701 |
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Synovitis | 296.79 | 9.58 | 34 | 219819 | 150700 | 79373835 |
| Cardiac failure congestive | 263.56 | 9.58 | 928 | 218925 | 141474 | 79383061 |
| Drug abuse | 258.32 | 9.58 | 65 | 219788 | 162626 | 79361909 |
| Maternal exposure during pregnancy | 249.27 | 9.58 | 39 | 219814 | 136499 | 79388036 |
| Drug ineffective | 244.77 | 9.58 | 1863 | 217990 | 1079050 | 78445485 |
| Hand deformity | 239.82 | 9.58 | 11 | 219842 | 103908 | 79420627 |
| Angioedema | 229.45 | 9.58 | 589 | 219264 | 75446 | 79449089 |
| Myocardial infarction | 227.29 | 9.58 | 1058 | 218795 | 183071 | 79341464 |
| Off label use | 214.48 | 9.58 | 1544 | 218309 | 905671 | 78618864 |
| Pemphigus | 213.22 | 9.58 | 16 | 219837 | 99566 | 79424969 |
| Infusion related reaction | 198.48 | 9.58 | 205 | 219648 | 230032 | 79294503 |
| Contraindicated product administered | 189.20 | 9.58 | 99 | 219754 | 157439 | 79367096 |
| Systemic lupus erythematosus | 185.47 | 9.58 | 52 | 219801 | 121097 | 79403438 |
| Cardiospasm | 173.26 | 9.58 | 110 | 219743 | 3191 | 79521344 |
| Blood glucose increased | 171.09 | 9.58 | 699 | 219154 | 114276 | 79410259 |
| Dizziness | 169.42 | 9.58 | 2204 | 217649 | 524237 | 79000298 |
| Acute kidney injury | 165.65 | 9.58 | 2171 | 217682 | 517233 | 79007302 |
| Treatment failure | 160.71 | 9.58 | 140 | 219713 | 170346 | 79354189 |
| Palmoplantar keratoderma | 159.01 | 9.58 | 109 | 219744 | 3607 | 79520928 |
| Febrile neutropenia | 156.26 | 9.58 | 247 | 219606 | 230752 | 79293783 |
| Drug intolerance | 153.84 | 9.58 | 310 | 219543 | 263809 | 79260726 |
| Sleep terror | 152.23 | 9.58 | 114 | 219739 | 4344 | 79520191 |
| Pruritus genital | 147.17 | 9.58 | 112 | 219741 | 4374 | 79520161 |
| Rheumatoid factor positive | 146.16 | 9.58 | 4 | 219849 | 59835 | 79464700 |
| Duodenal ulcer perforation | 143.57 | 9.58 | 10 | 219843 | 66201 | 79458334 |
| Anosmia | 143.31 | 9.58 | 148 | 219705 | 8696 | 79515839 |
| Tension headache | 137.79 | 9.58 | 132 | 219721 | 7079 | 79517456 |
| Carotid artery occlusion | 133.08 | 9.58 | 133 | 219720 | 7514 | 79517021 |
| General physical health deterioration | 130.75 | 9.58 | 360 | 219493 | 274878 | 79249657 |
| Wound | 129.46 | 9.58 | 80 | 219773 | 116099 | 79408436 |
| Transient ischaemic attack | 128.86 | 9.58 | 378 | 219475 | 52317 | 79472218 |
| Hepatic enzyme increased | 127.55 | 9.58 | 191 | 219662 | 182419 | 79342116 |
| Folliculitis | 127.31 | 9.58 | 6 | 219847 | 55374 | 79469161 |
| Hyperkalaemia | 126.41 | 9.58 | 637 | 219216 | 113761 | 79410774 |
| Cerebrovascular accident | 125.47 | 9.58 | 795 | 219058 | 154497 | 79370038 |
| Helicobacter infection | 124.75 | 9.58 | 21 | 219832 | 69683 | 79454852 |
| Atrial tachycardia | 122.19 | 9.58 | 123 | 219730 | 7010 | 79517525 |
| Toxicity to various agents | 119.34 | 9.58 | 678 | 219175 | 420862 | 79103673 |
| Arthropathy | 119.15 | 9.58 | 190 | 219663 | 176921 | 79347614 |
| Glossodynia | 118.16 | 9.58 | 69 | 219784 | 103268 | 79421267 |
| Blood pressure increased | 116.21 | 9.58 | 987 | 218866 | 210373 | 79314162 |
| Acute myocardial infarction | 115.08 | 9.58 | 469 | 219384 | 76567 | 79447968 |
| Exposure during pregnancy | 113.56 | 9.58 | 69 | 219784 | 101063 | 79423472 |
| Feeling abnormal | 112.92 | 9.58 | 789 | 219064 | 158410 | 79366125 |
| C-reactive protein abnormal | 111.97 | 9.58 | 5 | 219848 | 48362 | 79476173 |
| Immunisation | 108.26 | 9.58 | 70 | 219783 | 2097 | 79522438 |
| Atrial fibrillation | 105.59 | 9.58 | 918 | 218935 | 196968 | 79327567 |
| Lower respiratory tract infection | 103.64 | 9.58 | 122 | 219731 | 129098 | 79395437 |
| Sleep disorder due to general medical condition, insomnia type | 99.22 | 9.58 | 5 | 219848 | 43551 | 79480984 |
| Neutropenia | 96.58 | 9.58 | 436 | 219417 | 287274 | 79237261 |
| Palpitations | 95.42 | 9.58 | 637 | 219216 | 125973 | 79398562 |
| Product substitution issue | 91.28 | 9.58 | 184 | 219669 | 20072 | 79504463 |
| Therapeutic product effect decreased | 89.76 | 9.58 | 199 | 219654 | 163664 | 79360871 |
| Hyponatraemia | 89.69 | 9.58 | 815 | 219038 | 177033 | 79347502 |
| Joint swelling | 86.69 | 9.58 | 455 | 219398 | 288191 | 79236344 |
| Coronary artery disease | 86.47 | 9.58 | 384 | 219469 | 65090 | 79459445 |
| Muscle injury | 86.08 | 9.58 | 15 | 219838 | 48546 | 79475989 |
| Rheumatoid arthritis | 85.19 | 9.58 | 292 | 219561 | 208178 | 79316357 |
| Pain of skin | 83.59 | 9.58 | 147 | 219706 | 14466 | 79510069 |
| COVID-19 | 82.80 | 9.58 | 729 | 219124 | 156945 | 79367590 |
| Product dose omission issue | 82.15 | 9.58 | 1043 | 218810 | 246494 | 79278041 |
| C-reactive protein increased | 81.60 | 9.58 | 144 | 219709 | 128883 | 79395652 |
| Myalgia | 81.40 | 9.58 | 826 | 219027 | 184815 | 79339720 |
| Diarrhoea | 80.77 | 9.58 | 3076 | 216777 | 877413 | 78647122 |
| Lip swelling | 80.28 | 9.58 | 272 | 219581 | 40639 | 79483896 |
| Chest pain | 77.97 | 9.58 | 1151 | 218702 | 281153 | 79243382 |
| Eye pruritus | 76.69 | 9.58 | 173 | 219680 | 20397 | 79504138 |
| Dry skin | 76.05 | 9.58 | 380 | 219473 | 67615 | 79456920 |
| Facial pain | 75.57 | 9.58 | 128 | 219725 | 12222 | 79512313 |
| Intestinal angioedema | 74.41 | 9.58 | 40 | 219813 | 843 | 79523692 |
| Dyspnoea | 74.33 | 9.58 | 2976 | 216877 | 854049 | 78670486 |
| Discomfort | 73.44 | 9.58 | 147 | 219706 | 125470 | 79399065 |
| Irritable bowel syndrome | 73.39 | 9.58 | 40 | 219813 | 62201 | 79462334 |
| Sprue-like enteropathy | 71.88 | 9.58 | 45 | 219808 | 1273 | 79523262 |
| Cough | 69.98 | 9.58 | 1409 | 218444 | 365380 | 79159155 |
| Infection | 69.80 | 9.58 | 386 | 219467 | 241326 | 79283209 |
| Pyrexia | 69.11 | 9.58 | 1388 | 218465 | 677321 | 78847214 |
| Memory impairment | 68.49 | 9.58 | 535 | 219318 | 111199 | 79413336 |
| Visual impairment | 68.48 | 9.58 | 462 | 219391 | 91669 | 79432866 |
| Blindness | 66.91 | 9.58 | 201 | 219652 | 28182 | 79496353 |
| Leukopenia | 65.86 | 9.58 | 139 | 219714 | 116374 | 79408161 |
| Ventricular tachycardia | 64.76 | 9.58 | 258 | 219595 | 41677 | 79482858 |
| Loss of employment | 64.49 | 9.58 | 55 | 219798 | 2532 | 79522003 |
| Hypertensive crisis | 62.72 | 9.58 | 161 | 219692 | 20609 | 79503926 |
| Tinnitus | 61.57 | 9.58 | 264 | 219589 | 44069 | 79480466 |
| Blood pressure inadequately controlled | 60.80 | 9.58 | 80 | 219773 | 6097 | 79518438 |
| Pancytopenia | 60.60 | 9.58 | 243 | 219610 | 165502 | 79359033 |
| Condition aggravated | 60.32 | 9.58 | 995 | 218858 | 500129 | 79024406 |
| Subarachnoid haemorrhage | 60.28 | 9.58 | 176 | 219677 | 24289 | 79500246 |
| Product use issue | 59.52 | 9.58 | 337 | 219516 | 209485 | 79315050 |
| Blood creatinine increased | 59.14 | 9.58 | 671 | 219182 | 154386 | 79370149 |
| Cardiac disorder | 58.99 | 9.58 | 346 | 219507 | 65411 | 79459124 |
| Myelosuppression | 58.56 | 9.58 | 19 | 219834 | 40277 | 79484258 |
| Rash papular | 56.26 | 9.58 | 160 | 219693 | 21756 | 79502779 |
| Muscle twitching | 56.15 | 9.58 | 173 | 219680 | 24591 | 79499944 |
| Therapeutic product effect incomplete | 56.10 | 9.58 | 201 | 219652 | 141444 | 79383091 |
| Lactic acidosis | 56.03 | 9.58 | 359 | 219494 | 70000 | 79454535 |
| Swelling | 52.72 | 9.58 | 365 | 219488 | 216346 | 79308189 |
| Chronic kidney disease | 51.73 | 9.58 | 336 | 219517 | 65818 | 79458717 |
| Muscle spasms | 50.80 | 9.58 | 719 | 219134 | 174011 | 79350524 |
| Coma | 50.50 | 9.58 | 128 | 219725 | 100521 | 79424014 |
| Fibromyalgia | 50.24 | 9.58 | 62 | 219791 | 64278 | 79460257 |
| Musculoskeletal stiffness | 50.22 | 9.58 | 280 | 219573 | 174728 | 79349807 |
| Hypersensitivity | 49.86 | 9.58 | 472 | 219381 | 261767 | 79262768 |
| Suicide attempt | 49.37 | 9.58 | 96 | 219757 | 82836 | 79441699 |
| Body height decreased | 48.67 | 9.58 | 86 | 219767 | 8494 | 79516041 |
| Vasculitis | 48.46 | 9.58 | 166 | 219687 | 24936 | 79499599 |
| Angina unstable | 47.74 | 9.58 | 126 | 219727 | 16401 | 79508134 |
| Syncope | 46.53 | 9.58 | 724 | 219129 | 178725 | 79345810 |
| Pregnancy | 46.07 | 9.58 | 9 | 219844 | 26842 | 79497693 |
| Red blood cell sedimentation rate abnormal | 45.93 | 9.58 | 3 | 219850 | 20960 | 79503575 |
| Hypertensive emergency | 45.84 | 9.58 | 47 | 219806 | 2738 | 79521797 |
| Fatigue | 45.69 | 9.58 | 3059 | 216794 | 926668 | 78597867 |
| Malaise | 45.57 | 9.58 | 1715 | 218138 | 488154 | 79036381 |
| Diplopia | 45.48 | 9.58 | 198 | 219655 | 33268 | 79491267 |
| Cytomegalovirus infection | 45.26 | 9.58 | 31 | 219822 | 42613 | 79481922 |
| Impaired healing | 45.13 | 9.58 | 110 | 219743 | 87545 | 79436990 |
| Malignant neoplasm progression | 45.03 | 9.58 | 207 | 219646 | 135783 | 79388752 |
| Dehydration | 43.87 | 9.58 | 943 | 218910 | 247244 | 79277291 |
| Product use in unapproved indication | 42.88 | 9.58 | 462 | 219391 | 249897 | 79274638 |
| Psoriasis | 42.34 | 9.58 | 405 | 219448 | 89182 | 79435353 |
| Skin discolouration | 42.18 | 9.58 | 224 | 219629 | 40810 | 79483725 |
| Overdose | 41.54 | 9.58 | 317 | 219536 | 183889 | 79340646 |
| Malignant mediastinal neoplasm | 41.37 | 9.58 | 33 | 219820 | 1382 | 79523153 |
| Neuroleptic malignant syndrome | 40.04 | 9.58 | 13 | 219840 | 27546 | 79496989 |
| Asthenia | 39.89 | 9.58 | 1758 | 218095 | 509931 | 79014604 |
| Abortion spontaneous | 39.34 | 9.58 | 16 | 219837 | 29491 | 79495044 |
| Fall | 39.04 | 9.58 | 1680 | 218173 | 485949 | 79038586 |
| Hypoglycaemia | 38.88 | 9.58 | 440 | 219413 | 101154 | 79423381 |
| Abdominal pain upper | 38.77 | 9.58 | 848 | 219005 | 222971 | 79301564 |
| Pruritus | 38.70 | 9.58 | 1390 | 218463 | 393258 | 79131277 |
| Haemophagocytic lymphohistiocytosis | 38.15 | 9.58 | 7 | 219846 | 21830 | 79502705 |
| Glomerular filtration rate decreased | 37.76 | 9.58 | 143 | 219710 | 22559 | 79501976 |
| Live birth | 37.45 | 9.58 | 4 | 219849 | 18740 | 79505795 |
| Drug resistance | 36.99 | 9.58 | 37 | 219816 | 42176 | 79482359 |
| Rheumatoid nodule | 36.76 | 9.58 | 3 | 219850 | 17435 | 79507100 |
| Back pain | 36.40 | 9.58 | 1097 | 218756 | 303083 | 79221452 |
| Vision blurred | 36.27 | 9.58 | 449 | 219404 | 105449 | 79419086 |
| Suspected suicide | 36.19 | 9.58 | 86 | 219767 | 10490 | 79514045 |
| Thrombocytopenia | 36.17 | 9.58 | 514 | 219339 | 264745 | 79259790 |
| Haemorrhagic stroke | 35.84 | 9.58 | 88 | 219765 | 10958 | 79513577 |
| Dermatitis atopic | 35.74 | 9.58 | 83 | 219770 | 9973 | 79514562 |
| Bone erosion | 35.17 | 9.58 | 4 | 219849 | 17843 | 79506692 |
| Mucosal inflammation | 34.98 | 9.58 | 100 | 219753 | 75480 | 79449055 |
| Blood pressure diastolic decreased | 34.78 | 9.58 | 20 | 219833 | 30196 | 79494339 |
| Product quality issue | 34.69 | 9.58 | 185 | 219668 | 33755 | 79490780 |
| Sedation | 34.56 | 9.58 | 56 | 219797 | 51839 | 79472696 |
| Amnesia | 34.35 | 9.58 | 294 | 219559 | 62763 | 79461772 |
| Liver injury | 34.16 | 9.58 | 65 | 219788 | 56549 | 79467986 |
| Blood pressure diastolic abnormal | 33.88 | 9.58 | 6 | 219847 | 19196 | 79505339 |
| Aspergillus infection | 33.78 | 9.58 | 6 | 219847 | 19155 | 79505380 |
| Pericarditis | 33.71 | 9.58 | 160 | 219693 | 104076 | 79420459 |
| Ill-defined disorder | 33.64 | 9.58 | 83 | 219770 | 65792 | 79458743 |
| Bundle branch block left | 33.48 | 9.58 | 88 | 219765 | 11425 | 79513110 |
| Drug dispensed to wrong patient | 33.30 | 9.58 | 22 | 219831 | 684 | 79523851 |
| Product taste abnormal | 33.23 | 9.58 | 36 | 219817 | 2235 | 79522300 |
| Poisoning deliberate | 32.97 | 9.58 | 6 | 219847 | 18822 | 79505713 |
| Therapy cessation | 32.62 | 9.58 | 196 | 219657 | 37366 | 79487169 |
| Hypotension | 32.38 | 9.58 | 1504 | 218349 | 438813 | 79085722 |
| Diabetic neuropathy | 32.33 | 9.58 | 60 | 219793 | 6156 | 79518379 |
| Septic shock | 32.28 | 9.58 | 202 | 219651 | 122599 | 79401936 |
| Hallucination | 32.19 | 9.58 | 370 | 219483 | 85375 | 79439160 |
| Insomnia | 32.02 | 9.58 | 894 | 218959 | 244276 | 79280259 |
| Muscular weakness | 31.77 | 9.58 | 621 | 219232 | 160108 | 79364427 |
| Loss of personal independence in daily activities | 31.71 | 9.58 | 160 | 219693 | 102420 | 79422115 |
| Inappropriate antidiuretic hormone secretion | 31.52 | 9.58 | 150 | 219703 | 26163 | 79498372 |
| Bone marrow failure | 31.44 | 9.58 | 58 | 219795 | 51049 | 79473486 |
| Epilepsy | 31.25 | 9.58 | 40 | 219813 | 40820 | 79483715 |
| Graft versus host disease | 30.55 | 9.58 | 3 | 219850 | 15023 | 79509512 |
| Product odour abnormal | 30.33 | 9.58 | 27 | 219826 | 1317 | 79523218 |
| Anti-neutrophil cytoplasmic antibody positive vasculitis | 30.26 | 9.58 | 44 | 219809 | 3685 | 79520850 |
| Red blood cell sedimentation rate increased | 30.20 | 9.58 | 50 | 219803 | 45892 | 79478643 |
| Ascites | 30.06 | 9.58 | 107 | 219746 | 75455 | 79449080 |
| Drug interaction | 30.06 | 9.58 | 1416 | 218437 | 413767 | 79110768 |
| Renal failure | 29.45 | 9.58 | 744 | 219109 | 200224 | 79324311 |
| Respiratory depression | 29.44 | 9.58 | 20 | 219833 | 27610 | 79496925 |
| Glycosylated haemoglobin increased | 29.33 | 9.58 | 118 | 219735 | 19142 | 79505393 |
| Premature delivery | 29.27 | 9.58 | 14 | 219839 | 23453 | 79501082 |
| Gastrointestinal disorder | 29.12 | 9.58 | 207 | 219646 | 121998 | 79402537 |
| Dengue fever | 28.69 | 9.58 | 22 | 219831 | 869 | 79523666 |
| Renal impairment | 28.66 | 9.58 | 602 | 219251 | 157181 | 79367354 |
| Oedema peripheral | 28.61 | 9.58 | 904 | 218949 | 251384 | 79273151 |
| Hepatic cytolysis | 28.47 | 9.58 | 20 | 219833 | 27131 | 79497404 |
| Drug dependence | 28.09 | 9.58 | 43 | 219810 | 40726 | 79483809 |
| Serotonin syndrome | 27.78 | 9.58 | 51 | 219802 | 44976 | 79479559 |
| Nasopharyngitis | 27.31 | 9.58 | 514 | 219339 | 253367 | 79271168 |
| Blister | 27.21 | 9.58 | 205 | 219648 | 119271 | 79405264 |
| Blood pressure systolic abnormal | 27.14 | 9.58 | 7 | 219846 | 17240 | 79507295 |
| Drug hypersensitivity | 26.91 | 9.58 | 623 | 219230 | 298293 | 79226242 |
| Dysphonia | 26.81 | 9.58 | 257 | 219596 | 56615 | 79467920 |
| Diabetic ketoacidosis | 26.48 | 9.58 | 173 | 219680 | 33949 | 79490586 |
| Mouth swelling | 26.12 | 9.58 | 54 | 219799 | 5997 | 79518538 |
| Sinusitis | 25.53 | 9.58 | 382 | 219471 | 195119 | 79329416 |
| Ageusia | 25.41 | 9.58 | 102 | 219751 | 16530 | 79508005 |
| Mobility decreased | 25.34 | 9.58 | 215 | 219638 | 121960 | 79402575 |
| Hip arthroplasty | 25.33 | 9.58 | 37 | 219816 | 35719 | 79488816 |
| Pneumonia aspiration | 25.21 | 9.58 | 97 | 219756 | 66870 | 79457665 |
| Bradycardia | 25.20 | 9.58 | 519 | 219334 | 135038 | 79389497 |
| Immune reconstitution inflammatory syndrome | 25.14 | 9.58 | 4 | 219849 | 13837 | 79510698 |
| Primary hyperaldosteronism | 25.09 | 9.58 | 11 | 219842 | 145 | 79524390 |
| Plasmapheresis | 24.85 | 9.58 | 18 | 219835 | 651 | 79523884 |
| Flatulence | 24.76 | 9.58 | 202 | 219651 | 42522 | 79482013 |
| Urinary tract infection | 24.73 | 9.58 | 958 | 218895 | 273554 | 79250981 |
| Hypomagnesaemia | 24.65 | 9.58 | 217 | 219636 | 46694 | 79477841 |
| Oral pain | 24.55 | 9.58 | 161 | 219692 | 31637 | 79492898 |
| Mydriasis | 24.46 | 9.58 | 9 | 219844 | 17634 | 79506901 |
| Blood pressure abnormal | 24.42 | 9.58 | 103 | 219750 | 17066 | 79507469 |
| Status epilepticus | 24.26 | 9.58 | 20 | 219833 | 25021 | 79499514 |
| Pathogen resistance | 24.20 | 9.58 | 5 | 219848 | 14337 | 79510198 |
| Diabetic foot | 24.04 | 9.58 | 39 | 219814 | 3593 | 79520942 |
| Intentional product use issue | 23.94 | 9.58 | 286 | 219567 | 151826 | 79372709 |
| Acute myeloid leukaemia | 23.86 | 9.58 | 30 | 219823 | 30855 | 79493680 |
| Poisoning | 23.49 | 9.58 | 21 | 219832 | 25251 | 79499284 |
| Gastrointestinal haemorrhage | 23.48 | 9.58 | 553 | 219300 | 147166 | 79377369 |
| Disease progression | 23.47 | 9.58 | 362 | 219491 | 184000 | 79340535 |
| CD30 expression | 23.46 | 9.58 | 8 | 219845 | 50 | 79524485 |
| Febrile bone marrow aplasia | 23.12 | 9.58 | 4 | 219849 | 13016 | 79511519 |
| Haematotoxicity | 23.12 | 9.58 | 7 | 219846 | 15512 | 79509023 |
| Posterior reversible encephalopathy syndrome | 23.07 | 9.58 | 23 | 219830 | 26258 | 79498277 |
| Balance disorder | 23.05 | 9.58 | 392 | 219461 | 98465 | 79426070 |
| Haemorrhage intracranial | 22.95 | 9.58 | 137 | 219716 | 26056 | 79498479 |
| Blood glucose decreased | 22.85 | 9.58 | 137 | 219716 | 26097 | 79498438 |
| Peripheral swelling | 22.45 | 9.58 | 933 | 218920 | 268684 | 79255851 |
| Cardiac valve disease | 22.20 | 9.58 | 49 | 219804 | 5692 | 79518843 |
| Dystonia | 22.12 | 9.58 | 16 | 219837 | 21383 | 79503152 |
| Headache | 22.00 | 9.58 | 2090 | 217763 | 651682 | 78872853 |
| Cutaneous T-cell dyscrasia | 21.99 | 9.58 | 8 | 219845 | 62 | 79524473 |
| Blood urea increased | 21.79 | 9.58 | 218 | 219635 | 48572 | 79475963 |
| Hepatotoxicity | 21.59 | 9.58 | 71 | 219782 | 51281 | 79473254 |
| Dysgeusia | 21.58 | 9.58 | 247 | 219606 | 56930 | 79467605 |
| Swollen tongue | 21.38 | 9.58 | 195 | 219658 | 42375 | 79482160 |
| Angiotensin converting enzyme inhibitor foetopathy | 21.35 | 9.58 | 7 | 219846 | 38 | 79524497 |
| Intentional overdose | 21.29 | 9.58 | 188 | 219665 | 105772 | 79418763 |
| Eye haemorrhage | 21.05 | 9.58 | 67 | 219786 | 9690 | 79514845 |
| Chikungunya virus infection | 21.02 | 9.58 | 11 | 219842 | 219 | 79524316 |
| Obstructive airways disorder | 20.90 | 9.58 | 34 | 219819 | 31425 | 79493110 |
| Abdominal pain | 20.83 | 9.58 | 870 | 218983 | 388699 | 79135836 |
| Full blood count decreased | 20.83 | 9.58 | 136 | 219717 | 26683 | 79497852 |
| Intentional self-injury | 20.65 | 9.58 | 36 | 219817 | 32383 | 79492152 |
| Paraplegia | 20.54 | 9.58 | 44 | 219809 | 5009 | 79519526 |
| Progressive multifocal leukoencephalopathy | 20.53 | 9.58 | 16 | 219837 | 20584 | 79503951 |
| Urine albumin/creatinine ratio increased | 20.34 | 9.58 | 15 | 219838 | 558 | 79523977 |
| Delirium | 20.33 | 9.58 | 143 | 219710 | 84484 | 79440051 |
| Carcinogenicity | 20.30 | 9.58 | 8 | 219845 | 79 | 79524456 |
| Multi-organ disorder | 20.22 | 9.58 | 30 | 219823 | 2558 | 79521977 |
| Diabetes mellitus inadequate control | 20.05 | 9.58 | 125 | 219728 | 24139 | 79500396 |
| Noninfectious peritonitis | 19.88 | 9.58 | 11 | 219842 | 246 | 79524289 |
| Hepatic failure | 19.77 | 9.58 | 94 | 219759 | 61118 | 79463417 |
| Sodium retention | 19.67 | 9.58 | 10 | 219843 | 187 | 79524348 |
| Hyperhidrosis | 19.64 | 9.58 | 552 | 219301 | 150940 | 79373595 |
| Schizophrenia | 19.59 | 9.58 | 9 | 219844 | 15431 | 79509104 |
| Cytokine release syndrome | 19.46 | 9.58 | 44 | 219809 | 35954 | 79488581 |
| Burning feet syndrome | 19.34 | 9.58 | 10 | 219843 | 194 | 79524341 |
| Post transplant lymphoproliferative disorder | 19.34 | 9.58 | 4 | 219849 | 11460 | 79513075 |
| Multiple organ dysfunction syndrome | 19.34 | 9.58 | 225 | 219628 | 120021 | 79404514 |
| Renal disorder | 19.22 | 9.58 | 189 | 219664 | 41916 | 79482619 |
| Hepatocellular injury | 19.19 | 9.58 | 67 | 219786 | 47526 | 79477009 |
| Oligohydramnios | 19.10 | 9.58 | 34 | 219819 | 3378 | 79521157 |
| Recalled product administered | 19.08 | 9.58 | 17 | 219836 | 830 | 79523705 |
| Device expulsion | 19.08 | 9.58 | 26 | 219827 | 25835 | 79498700 |
| Stomatitis | 19.07 | 9.58 | 287 | 219566 | 146470 | 79378065 |
| Drug tolerance decreased | 19.07 | 9.58 | 6 | 219847 | 12972 | 79511563 |
| Inflammation | 18.99 | 9.58 | 166 | 219687 | 93587 | 79430948 |
| Myopathy | 18.95 | 9.58 | 109 | 219744 | 20454 | 79504081 |
| Facet joint syndrome | 18.95 | 9.58 | 4 | 219849 | 11298 | 79513237 |
| Hyperlipidaemia | 18.87 | 9.58 | 130 | 219723 | 25963 | 79498572 |
| Miosis | 18.82 | 9.58 | 10 | 219843 | 15779 | 79508756 |
| Renal artery stenosis | 18.60 | 9.58 | 34 | 219819 | 3448 | 79521087 |
| Chromaturia | 18.46 | 9.58 | 128 | 219725 | 25618 | 79498917 |
| Cachexia | 18.42 | 9.58 | 4 | 219849 | 11079 | 79513456 |
| Atrioventricular block | 18.26 | 9.58 | 82 | 219771 | 13959 | 79510576 |
| Transplant rejection | 18.25 | 9.58 | 16 | 219837 | 19421 | 79505114 |
| High frequency ablation | 18.19 | 9.58 | 11 | 219842 | 292 | 79524243 |
| Eye irritation | 18.01 | 9.58 | 108 | 219745 | 20573 | 79503962 |
| Bromhidrosis | 17.85 | 9.58 | 5 | 219848 | 14 | 79524521 |
| Eye pain | 17.80 | 9.58 | 170 | 219683 | 37408 | 79487127 |
| Agranulocytosis | 17.75 | 9.58 | 64 | 219789 | 44966 | 79479569 |
| Autoimmune disorder | 17.73 | 9.58 | 12 | 219841 | 16600 | 79507935 |
| Gout | 17.72 | 9.58 | 123 | 219730 | 24626 | 79499909 |
| Panniculitis | 17.68 | 9.58 | 6 | 219847 | 12365 | 79512170 |
| Psoriatic arthropathy | 17.68 | 9.58 | 134 | 219719 | 77865 | 79446670 |
| Pseudolymphoma | 17.46 | 9.58 | 19 | 219834 | 1186 | 79523349 |
| Disability | 17.44 | 9.58 | 13 | 219840 | 17107 | 79507428 |
| Neurotoxicity | 17.38 | 9.58 | 40 | 219813 | 32478 | 79492057 |
| Glomerulonephritis rapidly progressive | 17.25 | 9.58 | 22 | 219831 | 1626 | 79522909 |
| Renal pain | 17.02 | 9.58 | 56 | 219797 | 8240 | 79516295 |
| Bronchopulmonary aspergillosis | 16.86 | 9.58 | 22 | 219831 | 22272 | 79502263 |
| Sialoadenitis | 16.80 | 9.58 | 24 | 219829 | 1977 | 79522558 |
| Disturbance in attention | 16.79 | 9.58 | 214 | 219639 | 50587 | 79473948 |
| Asthmatic crisis | 16.76 | 9.58 | 24 | 219829 | 1982 | 79522553 |
| Therapy partial responder | 16.73 | 9.58 | 14 | 219839 | 17383 | 79507152 |
| Alanine aminotransferase increased | 16.60 | 9.58 | 332 | 219521 | 162238 | 79362297 |
| Pseudomonas infection | 16.47 | 9.58 | 20 | 219833 | 20883 | 79503652 |
| Muscle spasticity | 16.44 | 9.58 | 21 | 219832 | 21454 | 79503081 |
| Blood pressure decreased | 16.30 | 9.58 | 374 | 219479 | 99092 | 79425443 |
| Body temperature increased | 16.30 | 9.58 | 65 | 219788 | 44355 | 79480180 |
| Blood potassium decreased | 16.26 | 9.58 | 198 | 219655 | 46314 | 79478221 |
| Decreased immune responsiveness | 16.08 | 9.58 | 42 | 219811 | 5433 | 79519102 |
| Hyperglycaemia | 16.07 | 9.58 | 278 | 219575 | 70057 | 79454478 |
| Epstein-Barr virus infection | 15.95 | 9.58 | 10 | 219843 | 14406 | 79510129 |
| Gamma-glutamyltransferase increased | 15.94 | 9.58 | 87 | 219766 | 54593 | 79469942 |
| Non-cardiac chest pain | 15.84 | 9.58 | 60 | 219793 | 9464 | 79515071 |
| Thymus disorder | 15.84 | 9.58 | 10 | 219843 | 287 | 79524248 |
| Neutrophil count decreased | 15.82 | 9.58 | 174 | 219679 | 93785 | 79430750 |
| Pneumocystis jirovecii pneumonia | 15.80 | 9.58 | 42 | 219811 | 32466 | 79492069 |
| Tumour lysis syndrome | 15.78 | 9.58 | 26 | 219827 | 23913 | 79500622 |
| Transient aphasia | 15.78 | 9.58 | 12 | 219841 | 468 | 79524067 |
| Spider naevus | 15.72 | 9.58 | 8 | 219845 | 150 | 79524385 |
| Accelerated hypertension | 15.64 | 9.58 | 14 | 219839 | 688 | 79523847 |
| Hepatic steatosis | 15.60 | 9.58 | 166 | 219687 | 37572 | 79486963 |
| Gastroenteritis eosinophilic | 15.60 | 9.58 | 10 | 219843 | 295 | 79524240 |
| Psychotic disorder | 15.56 | 9.58 | 60 | 219793 | 41342 | 79483193 |
| Extrapyramidal disorder | 15.55 | 9.58 | 24 | 219829 | 22655 | 79501880 |
| Neutropenic sepsis | 15.53 | 9.58 | 32 | 219821 | 27032 | 79497503 |
| Mitral valve incompetence | 15.46 | 9.58 | 133 | 219720 | 28432 | 79496103 |
| Aggression | 15.45 | 9.58 | 80 | 219773 | 50878 | 79473657 |
| Joint range of motion decreased | 15.42 | 9.58 | 44 | 219809 | 33238 | 79491297 |
| Product physical issue | 15.38 | 9.58 | 35 | 219818 | 4150 | 79520385 |
| Hypoparathyroidism | 15.36 | 9.58 | 17 | 219836 | 1081 | 79523454 |
| Injury | 15.35 | 9.58 | 138 | 219715 | 77358 | 79447177 |
| Thyroid disorder | 15.25 | 9.58 | 78 | 219775 | 14001 | 79510534 |
| Grip strength decreased | 15.13 | 9.58 | 23 | 219830 | 21846 | 79502689 |
| Erectile dysfunction | 15.03 | 9.58 | 80 | 219773 | 14584 | 79509951 |
| Ischaemic cardiomyopathy | 14.95 | 9.58 | 51 | 219802 | 7644 | 79516891 |
| Cardiomegaly | 14.95 | 9.58 | 124 | 219729 | 26228 | 79498307 |
| Respiratory arrest | 14.95 | 9.58 | 95 | 219758 | 57455 | 79467080 |
| Milk-alkali syndrome | 14.93 | 9.58 | 19 | 219834 | 1401 | 79523134 |
| Blood pressure fluctuation | 14.91 | 9.58 | 116 | 219737 | 67029 | 79457506 |
| Extravasation blood | 14.83 | 9.58 | 11 | 219842 | 413 | 79524122 |
| Hyperammonaemia | 14.81 | 9.58 | 6 | 219847 | 11087 | 79513448 |
| Linear IgA disease | 14.77 | 9.58 | 29 | 219824 | 3103 | 79521432 |
| Pancreatitis acute | 14.75 | 9.58 | 205 | 219648 | 49399 | 79475136 |
| Coronary artery occlusion | 14.65 | 9.58 | 82 | 219771 | 15233 | 79509302 |
| Product residue present | 14.61 | 9.58 | 31 | 219822 | 3505 | 79521030 |
| Oral candidiasis | 14.61 | 9.58 | 38 | 219815 | 29590 | 79494945 |
| Eosinophilia myalgia syndrome | 14.60 | 9.58 | 4 | 219849 | 10 | 79524525 |
| Enterococcal infection | 14.57 | 9.58 | 13 | 219840 | 15647 | 79508888 |
| Body temperature decreased | 14.53 | 9.58 | 43 | 219810 | 32102 | 79492433 |
| Generalised tonic-clonic seizure | 14.43 | 9.58 | 67 | 219786 | 43843 | 79480692 |
| Calciphylaxis | 14.38 | 9.58 | 32 | 219821 | 3738 | 79520797 |
| Renin decreased | 14.37 | 9.58 | 7 | 219846 | 119 | 79524416 |
| Hypersensitivity vasculitis | 14.36 | 9.58 | 47 | 219806 | 6896 | 79517639 |
| Depressed level of consciousness | 14.35 | 9.58 | 184 | 219669 | 96468 | 79428067 |
| Rash maculo-papular | 14.34 | 9.58 | 93 | 219760 | 55985 | 79468550 |
| Carotid bruit | 14.33 | 9.58 | 14 | 219839 | 769 | 79523766 |
| Papillary muscle rupture | 14.33 | 9.58 | 4 | 219849 | 11 | 79524524 |
| Cardiac failure | 14.32 | 9.58 | 542 | 219311 | 154300 | 79370235 |
| Hypocalvaria | 14.31 | 9.58 | 5 | 219848 | 34 | 79524501 |
| Ischaemic stroke | 14.30 | 9.58 | 147 | 219706 | 32984 | 79491551 |
| Weight increased | 14.29 | 9.58 | 622 | 219231 | 276764 | 79247771 |
| Angina pectoris | 14.27 | 9.58 | 211 | 219642 | 51521 | 79473014 |
| Pain | 14.25 | 9.58 | 1711 | 218142 | 702091 | 78822444 |
| Blood immunoglobulin E increased | 14.19 | 9.58 | 42 | 219811 | 5840 | 79518695 |
| Acute respiratory distress syndrome | 14.04 | 9.58 | 68 | 219785 | 43999 | 79480536 |
| Rhabdomyolysis | 13.99 | 9.58 | 378 | 219475 | 102753 | 79421782 |
| Shoshin beriberi | 13.90 | 9.58 | 6 | 219847 | 76 | 79524459 |
| Diabetic retinopathy | 13.74 | 9.58 | 28 | 219825 | 3078 | 79521457 |
| Photopsia | 13.74 | 9.58 | 39 | 219814 | 5297 | 79519238 |
| Agitation | 13.65 | 9.58 | 193 | 219660 | 99522 | 79425013 |
| Chronic obstructive pulmonary disease | 13.63 | 9.58 | 320 | 219533 | 85099 | 79439436 |
| Carotid artery stenosis | 13.61 | 9.58 | 54 | 219799 | 8704 | 79515831 |
| Haematuria | 13.60 | 9.58 | 266 | 219587 | 68570 | 79455965 |
| Oral mucosal blistering | 13.55 | 9.58 | 43 | 219810 | 6208 | 79518327 |
| Cardiac flutter | 13.53 | 9.58 | 37 | 219816 | 4917 | 79519618 |
| Heart rate increased | 13.52 | 9.58 | 432 | 219421 | 120292 | 79404243 |
| Bradyarrhythmia | 13.42 | 9.58 | 33 | 219820 | 4113 | 79520422 |
| Hypertensive encephalopathy | 13.39 | 9.58 | 15 | 219838 | 967 | 79523568 |
| Peri-implantitis | 13.34 | 9.58 | 8 | 219845 | 209 | 79524326 |
| Low density lipoprotein increased | 13.27 | 9.58 | 53 | 219800 | 8569 | 79515966 |
| Norepinephrine increased | 13.24 | 9.58 | 6 | 219847 | 86 | 79524449 |
| Venous occlusion | 13.22 | 9.58 | 16 | 219837 | 1121 | 79523414 |
| Rebound tachycardia | 13.19 | 9.58 | 4 | 219849 | 16 | 79524519 |
| Multiple-drug resistance | 13.07 | 9.58 | 4 | 219849 | 8804 | 79515731 |
| Therapeutic response unexpected | 13.05 | 9.58 | 97 | 219756 | 19849 | 79504686 |
| Tendon rupture | 13.01 | 9.58 | 67 | 219786 | 12059 | 79512476 |
| Sickle cell anaemia with crisis | 12.89 | 9.58 | 3 | 219850 | 7919 | 79516616 |
| Therapeutic response decreased | 12.83 | 9.58 | 120 | 219733 | 66733 | 79457802 |
| Dislocation of vertebra | 12.79 | 9.58 | 3 | 219850 | 7877 | 79516658 |
| Infective pulmonary exacerbation of cystic fibrosis | 12.78 | 9.58 | 10 | 219843 | 12841 | 79511694 |
| Nodular rash | 12.76 | 9.58 | 9 | 219844 | 312 | 79524223 |
| Near death experience | 12.76 | 9.58 | 11 | 219842 | 514 | 79524021 |
| Osteoporosis | 12.72 | 9.58 | 92 | 219761 | 54020 | 79470515 |
| Hypovolaemia | 12.71 | 9.58 | 88 | 219765 | 17603 | 79506932 |
| Diffuse large B-cell lymphoma | 12.67 | 9.58 | 9 | 219844 | 12140 | 79512395 |
| Poor venous access | 12.64 | 9.58 | 19 | 219834 | 18130 | 79506405 |
| B-cell small lymphocytic lymphoma stage IV | 12.62 | 9.58 | 3 | 219850 | 3 | 79524532 |
| Tubulointerstitial nephritis | 12.61 | 9.58 | 161 | 219692 | 38074 | 79486461 |
| Granulocytopenia | 12.55 | 9.58 | 8 | 219845 | 11423 | 79513112 |
| Cholestasis | 12.54 | 9.58 | 88 | 219765 | 52021 | 79472514 |
| Cerebellar haemorrhage | 12.53 | 9.58 | 26 | 219827 | 2894 | 79521641 |
| Blood pressure systolic increased | 12.53 | 9.58 | 121 | 219732 | 66865 | 79457670 |
| Faeces discoloured | 12.46 | 9.58 | 129 | 219724 | 28998 | 79495537 |
| Myeloma cast nephropathy | 12.43 | 9.58 | 7 | 219846 | 162 | 79524373 |
| Unintentional medical device removal | 12.39 | 9.58 | 3 | 219850 | 7709 | 79516826 |
| Blindness transient | 12.39 | 9.58 | 35 | 219818 | 4741 | 79519794 |
| Gait disturbance | 12.38 | 9.58 | 695 | 219158 | 206811 | 79317724 |
| Lymphocyte count decreased | 12.31 | 9.58 | 78 | 219775 | 47211 | 79477324 |
| Heat stroke | 12.26 | 9.58 | 19 | 219834 | 1684 | 79522851 |
| Aortic dissection | 12.23 | 9.58 | 32 | 219821 | 4143 | 79520392 |
| Atheroembolism | 12.20 | 9.58 | 9 | 219844 | 335 | 79524200 |
| Arrhythmia | 12.19 | 9.58 | 237 | 219616 | 61035 | 79463500 |
| Pseudoaldosteronism | 12.17 | 9.58 | 7 | 219846 | 169 | 79524366 |
| Oxygen saturation decreased | 12.15 | 9.58 | 267 | 219586 | 128780 | 79395755 |
| Blood parathyroid hormone decreased | 12.09 | 9.58 | 7 | 219846 | 10529 | 79514006 |
| Atrioventricular block first degree | 12.03 | 9.58 | 67 | 219786 | 12424 | 79512111 |
| Product dispensing error | 12.03 | 9.58 | 70 | 219783 | 13193 | 79511342 |
| Respiratory rate increased | 12.01 | 9.58 | 26 | 219827 | 21574 | 79502961 |
| Sleep disorder due to a general medical condition | 11.96 | 9.58 | 13 | 219840 | 14264 | 79510271 |
| Loss of consciousness | 11.95 | 9.58 | 572 | 219281 | 167371 | 79357164 |
| Drug level below therapeutic | 11.93 | 9.58 | 6 | 219847 | 9764 | 79514771 |
| Patella fracture | 11.87 | 9.58 | 20 | 219833 | 1901 | 79522634 |
| Cardiorenal syndrome | 11.82 | 9.58 | 18 | 219835 | 1571 | 79522964 |
| Eczema nummular | 11.81 | 9.58 | 9 | 219844 | 352 | 79524183 |
| Blood glucose abnormal | 11.77 | 9.58 | 59 | 219794 | 10507 | 79514028 |
| Spinal epidural haematoma | 11.77 | 9.58 | 17 | 219836 | 1415 | 79523120 |
| Hypogammaglobulinaemia | 11.76 | 9.58 | 11 | 219842 | 12940 | 79511595 |
| Fear | 11.70 | 9.58 | 102 | 219751 | 21884 | 79502651 |
| Blindness unilateral | 11.69 | 9.58 | 49 | 219804 | 8097 | 79516438 |
| Type 2 diabetes mellitus | 11.63 | 9.58 | 101 | 219752 | 57021 | 79467514 |
| Anuria | 11.55 | 9.58 | 98 | 219755 | 20865 | 79503670 |
| Injection site reaction | 11.54 | 9.58 | 96 | 219757 | 54689 | 79469846 |
| Instillation site pain | 11.54 | 9.58 | 12 | 219841 | 711 | 79523824 |
| Scleroderma renal crisis | 11.48 | 9.58 | 11 | 219842 | 590 | 79523945 |
| Device related infection | 11.46 | 9.58 | 52 | 219801 | 34242 | 79490293 |
| Knee arthroplasty | 11.43 | 9.58 | 71 | 219782 | 43177 | 79481358 |
| Pollakiuria | 11.41 | 9.58 | 155 | 219698 | 37162 | 79487373 |
| Parathyroid haemorrhage | 11.41 | 9.58 | 3 | 219850 | 6 | 79524529 |
| Diabetes mellitus | 11.41 | 9.58 | 290 | 219563 | 78100 | 79446435 |
| Vascular stenosis | 11.40 | 9.58 | 11 | 219842 | 595 | 79523940 |
| Guillain-Barre syndrome | 11.40 | 9.58 | 52 | 219801 | 8913 | 79515622 |
| Psychomotor hyperactivity | 11.39 | 9.58 | 18 | 219835 | 16831 | 79507704 |
| Overweight | 11.34 | 9.58 | 31 | 219822 | 4119 | 79520416 |
| Blood triglycerides abnormal | 11.32 | 9.58 | 10 | 219843 | 483 | 79524052 |
| Hepatic function abnormal | 11.29 | 9.58 | 138 | 219715 | 72969 | 79451566 |
| Fluid retention | 11.29 | 9.58 | 262 | 219591 | 69547 | 79454988 |
| Pancreatic carcinoma | 11.25 | 9.58 | 70 | 219783 | 13507 | 79511028 |
| Wrong product administered | 11.25 | 9.58 | 52 | 219801 | 8960 | 79515575 |
| Gastroenteritis aeromonas | 11.23 | 9.58 | 4 | 219849 | 29 | 79524506 |
| Depressed mood | 11.21 | 9.58 | 192 | 219661 | 48288 | 79476247 |
| Therapy interrupted | 11.21 | 9.58 | 134 | 219719 | 31207 | 79493328 |
| Eosinophilia | 11.20 | 9.58 | 76 | 219777 | 45269 | 79479266 |
| Orthopnoea | 11.05 | 9.58 | 56 | 219797 | 10017 | 79514518 |
| Lichen planus | 11.00 | 9.58 | 24 | 219829 | 2767 | 79521768 |
| Haemorrhagic fever | 11.00 | 9.58 | 4 | 219849 | 31 | 79524504 |
| Frequent bowel movements | 10.98 | 9.58 | 43 | 219810 | 29496 | 79495039 |
| Application site haematoma | 10.95 | 9.58 | 5 | 219848 | 73 | 79524462 |
| Nephrolithiasis | 10.89 | 9.58 | 207 | 219646 | 53084 | 79471451 |
| Device adhesion issue | 10.89 | 9.58 | 3 | 219850 | 7072 | 79517463 |
| Mitral valve stenosis | 10.89 | 9.58 | 15 | 219838 | 1195 | 79523340 |
| Normal newborn | 10.88 | 9.58 | 3 | 219850 | 7069 | 79517466 |
| Periorbital oedema | 10.88 | 9.58 | 49 | 219804 | 8353 | 79516182 |
| Lip dry | 10.88 | 9.58 | 16 | 219837 | 15402 | 79509133 |
| Anticoagulation drug level above therapeutic | 10.87 | 9.58 | 28 | 219825 | 3592 | 79520943 |
| Urethral haemorrhage | 10.86 | 9.58 | 9 | 219844 | 398 | 79524137 |
| Device dislocation | 10.85 | 9.58 | 36 | 219817 | 25934 | 79498601 |
| Essential hypertension | 10.80 | 9.58 | 39 | 219814 | 6014 | 79518521 |
| Hypokalaemia | 10.76 | 9.58 | 493 | 219360 | 143547 | 79380988 |
| Nail bed tenderness | 10.73 | 9.58 | 9 | 219844 | 405 | 79524130 |
| Pulmonary oedema | 10.73 | 9.58 | 319 | 219534 | 87935 | 79436600 |
| Nervousness | 10.72 | 9.58 | 140 | 219713 | 33275 | 79491260 |
| Application site scab | 10.70 | 9.58 | 7 | 219846 | 214 | 79524321 |
| Aortic stenosis | 10.69 | 9.58 | 45 | 219808 | 7450 | 79517085 |
| Blood magnesium decreased | 10.63 | 9.58 | 80 | 219773 | 16432 | 79508103 |
| Hyperthermia | 10.63 | 9.58 | 21 | 219832 | 18016 | 79506519 |
| Blood aldosterone increased | 10.50 | 9.58 | 7 | 219846 | 221 | 79524314 |
| Blood loss anaemia | 10.50 | 9.58 | 76 | 219777 | 15422 | 79509113 |
| Orbital oedema | 10.48 | 9.58 | 9 | 219844 | 418 | 79524117 |
| Electrocardiogram PR prolongation | 10.48 | 9.58 | 17 | 219836 | 1566 | 79522969 |
| Arrhythmia supraventricular | 10.40 | 9.58 | 20 | 219833 | 2107 | 79522428 |
| Blood potassium increased | 10.40 | 9.58 | 125 | 219728 | 29150 | 79495385 |
| Anhidrosis | 10.39 | 9.58 | 7 | 219846 | 225 | 79524310 |
| Product availability issue | 10.31 | 9.58 | 29 | 219824 | 3918 | 79520617 |
| Hyponatraemic seizure | 10.30 | 9.58 | 10 | 219843 | 545 | 79523990 |
| Microcytic anaemia | 10.29 | 9.58 | 35 | 219818 | 5239 | 79519296 |
| Drug ineffective for unapproved indication | 10.25 | 9.58 | 91 | 219762 | 51147 | 79473388 |
| Nasal congestion | 10.22 | 9.58 | 280 | 219573 | 76272 | 79448263 |
| Parathyroid tumour | 10.21 | 9.58 | 5 | 219848 | 86 | 79524449 |
| Nausea | 10.21 | 9.58 | 2873 | 216980 | 954323 | 78570212 |
| Clostridium difficile colitis | 10.17 | 9.58 | 50 | 219803 | 32233 | 79492302 |
| Extrasystoles | 10.16 | 9.58 | 44 | 219809 | 7375 | 79517160 |
| Cytopenia | 10.16 | 9.58 | 26 | 219827 | 20357 | 79504178 |
| Metastatic renal cell carcinoma | 10.14 | 9.58 | 21 | 219832 | 2334 | 79522201 |
| Gastric disorder | 10.06 | 9.58 | 152 | 219701 | 37281 | 79487254 |
| Umbilical hernia repair | 10.06 | 9.58 | 5 | 219848 | 89 | 79524446 |
| Fear of injection | 10.05 | 9.58 | 4 | 219849 | 7470 | 79517065 |
| Vasculitic rash | 10.03 | 9.58 | 20 | 219833 | 2164 | 79522371 |
| Myocardial ischaemia | 9.97 | 9.58 | 111 | 219742 | 25408 | 79499127 |
| Vitamin B6 deficiency | 9.97 | 9.58 | 8 | 219845 | 338 | 79524197 |
| Generalised anxiety disorder | 9.95 | 9.58 | 20 | 219833 | 2177 | 79522358 |
| Drug specific antibody present | 9.91 | 9.58 | 3 | 219850 | 6649 | 79517886 |
| Sputum discoloured | 9.89 | 9.58 | 29 | 219824 | 21714 | 79502821 |
| Colitis microscopic | 9.87 | 9.58 | 57 | 219796 | 10711 | 79513824 |
| Thrombotic microangiopathy | 9.84 | 9.58 | 26 | 219827 | 20143 | 79504392 |
| Blood urea abnormal | 9.82 | 9.58 | 15 | 219838 | 1312 | 79523223 |
| Encephalitis | 9.76 | 9.58 | 16 | 219837 | 14744 | 79509791 |
| Encephalopathy | 9.74 | 9.58 | 129 | 219724 | 67268 | 79457267 |
| Product supply issue | 9.70 | 9.58 | 19 | 219834 | 2029 | 79522506 |
| Creatinine renal clearance decreased | 9.66 | 9.58 | 24 | 219829 | 18978 | 79505557 |
| Lung disorder | 9.63 | 9.58 | 160 | 219693 | 80397 | 79444138 |
| Pneumonia fungal | 9.62 | 9.58 | 10 | 219843 | 11200 | 79513335 |
| Familial periodic paralysis | 9.61 | 9.58 | 6 | 219847 | 169 | 79524366 |
| Prescribed overdose | 9.60 | 9.58 | 63 | 219790 | 37820 | 79486715 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | C09CA01 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), PLAIN Angiotensin II receptor blockers (ARBs), plain |
| ATC | C09DA01 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS Angiotensin II receptor blockers (ARBs) and diuretics |
| ATC | C09DB06 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS Angiotensin II receptor blockers (ARBs) and calcium channel blockers |
| FDA MoA | N0000000070 | Angiotensin 2 Receptor Antagonists |
| FDA EPC | N0000175561 | Angiotensin 2 Receptor Blocker |
| CHEBI has role | CHEBI:35674 | antihypertensive drugs |
| CHEBI has role | CHEBI:38070 | antiarrhythmic agent |
| CHEBI has role | CHEBI:51451 | ERA |
| CHEBI has role | CHEBI:61016 | angiotensin receptor antagonists |
| MeSH PA | D047228 | Angiotensin II Type 1 Receptor Blockers |
| MeSH PA | D057911 | Angiotensin Receptor Antagonists |
| MeSH PA | D000889 | Anti-Arrhythmia Agents |
| MeSH PA | D000959 | Antihypertensive Agents |
| MeSH PA | D002317 | Cardiovascular Agents |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Hypertensive disorder | indication | 38341003 | DOID:10763 |
| Diabetic renal disease | indication | 127013003 | |
| Hypertensive urgency | indication | 443482000 | |
| Hypertension with Left Ventricular Hypertrophy | indication | ||
| Chronic heart failure | off-label use | 48447003 | |
| Atrial fibrillation | off-label use | 49436004 | DOID:0060224 |
| Diastolic heart failure | off-label use | 418304008 | DOID:9775 |
| Nondiabetic Proteinuric Nephropathy | off-label use | ||
| Anuria | contraindication | 2472002 | DOID:2983 |
| Hypercholesterolemia | contraindication | 13644009 | |
| Hyperkalemia | contraindication | 14140009 | |
| Secondary angle-closure glaucoma | contraindication | 21571006 | |
| Hypovolemia | contraindication | 28560003 | |
| Dehydration | contraindication | 34095006 | |
| Hyperuricemia | contraindication | 35885006 | DOID:1920 |
| Hypokalemia | contraindication | 43339004 | |
| Low blood pressure | contraindication | 45007003 | |
| Systemic lupus erythematosus | contraindication | 55464009 | DOID:9074 |
| Sympathectomy | contraindication | 57071006 | |
| Hypercalcemia | contraindication | 66931009 | DOID:12678 |
| Hyperparathyroidism | contraindication | 66999008 | DOID:13543 |
| Hypochloremic alkalosis | contraindication | 70134007 | |
| Hepatic coma | contraindication | 72836002 | DOID:12550 |
| Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
| Hyponatremia | contraindication | 89627008 | |
| Gout | contraindication | 90560007 | DOID:13189 |
| Hypomagnesemia | contraindication | 190855004 | |
| Acute pancreatitis | contraindication | 197456007 | DOID:2913 |
| Impaired renal function disorder | contraindication | 197663003 | |
| Disease of liver | contraindication | 235856003 | DOID:409 |
| Neonatal hyperbilirubinemia | contraindication | 281610001 | |
| Pregnancy, function | contraindication | 289908002 | |
| Renal artery stenosis | contraindication | 302233006 | |
| Azotemia | contraindication | 445009001 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 4.5 | acidic |
| pKa2 | 13.19 | acidic |
| pKa3 | 3.89 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Type-1 angiotensin II receptor | GPCR | ANTAGONIST | IC50 | 9.48 | CHEMBL | CHEMBL | |||
| Angiotensin-converting enzyme | Enzyme | IC50 | 7.72 | CHEMBL | |||||
| ATP-binding cassette sub-family G member 2 | Transporter | IC50 | 4.46 | CHEMBL | |||||
| Cytochrome P450 2C9 | Enzyme | IC50 | 5.54 | DRUG MATRIX | |||||
| Thromboxane A2 receptor | GPCR | IC50 | 4.70 | CHEMBL | |||||
| Type-2 angiotensin II receptor | GPCR | IC50 | 5 | CHEMBL | |||||
| Phosphodiesterase 3 | Enzyme | IC50 | 4.89 | CHEMBL | |||||
| Phosphodiesterase 4 | Enzyme | IC50 | 4.59 | CHEMBL | |||||
| Angiotensin II receptor | GPCR | Kd | 8.43 | CHEMBL | |||||
| Multidrug resistance protein 1 | Transporter | Km | 3.50 | WOMBAT-PK | |||||
| Platelet glycoprotein VI | Unclassified | IC50 | 4.98 | CHEMBL | |||||
| Type-1B angiotensin II receptor | GPCR | Ki | 8.44 | CHEMBL | |||||
| Type-2 angiotensin II receptor | GPCR | IC50 | 5.13 | CHEMBL | |||||
| Type-1 angiotensin II receptor | GPCR | IC50 | 7.02 | CHEMBL | |||||
| Type-1A angiotensin II receptor | GPCR | Ki | 7.84 | CHEMBL | |||||
| Type-1 angiotensin II receptor | GPCR | Kd | 8.80 | CHEMBL | |||||
| Type-1 angiotensin II receptor | GPCR | IC50 | 7.74 | CHEMBL | |||||
| Angiotensin II receptor (AT-1) type-1 | GPCR | Ki | 8.72 | CHEMBL | |||||
| Angiotensin II receptor | GPCR | IC50 | 8.34 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4020913 | VUID |
| N0000148401 | NUI |
| D00357 | KEGG_DRUG |
| 124750-99-8 | SECONDARY_CAS_RN |
| 4020913 | VANDF |
| 4020920 | VANDF |
| C0126174 | UMLSCUI |
| CHEBI:6541 | CHEBI |
| LSN | PDB_CHEM_ID |
| CHEMBL191 | ChEMBL_ID |
| CHEMBL995 | ChEMBL_ID |
| D019808 | MESH_DESCRIPTOR_UI |
| DB00678 | DRUGBANK_ID |
| 3961 | PUBCHEM_CID |
| 590 | IUPHAR_LIGAND_ID |
| 6913 | INN_ID |
| JMS50MPO89 | UNII |
| 203160 | RXNORM |
| 172424 | MMSL |
| 4996 | MMSL |
| d03821 | MMSL |
| 004991 | NDDF |
| 004992 | NDDF |
| 108582002 | SNOMEDCT_US |
| 373567002 | SNOMEDCT_US |
| 96309000 | SNOMEDCT_US |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Losartan Potassium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0123 | TABLET | 25 mg | ORAL | ANDA | 26 sections |
| Losartan Potassium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0124 | TABLET | 50 mg | ORAL | ANDA | 26 sections |
| Losartan Potassium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0125 | TABLET | 100 mg | ORAL | ANDA | 26 sections |
| Losartan Potassium and Hydrochlorothiazide | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0093-7367 | TABLET, FILM COATED | 50 mg | ORAL | ANDA | 26 sections |
| Losartan Potassium and Hydrochlorothiazide | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0093-7367 | TABLET, FILM COATED | 50 mg | ORAL | ANDA | 26 sections |
| Losartan Potassium and Hydrochlorothiazide | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0093-7368 | TABLET, FILM COATED | 100 mg | ORAL | ANDA | 26 sections |
| Losartan Potassium and Hydrochlorothiazide | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0093-7368 | TABLET, FILM COATED | 100 mg | ORAL | ANDA | 26 sections |
| Losartan Potassium and Hydrochlorothiazide | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0093-7369 | TABLET, FILM COATED | 100 mg | ORAL | ANDA | 26 sections |
| Losartan Potassium and Hydrochlorothiazide | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0093-7369 | TABLET, FILM COATED | 100 mg | ORAL | ANDA | 26 sections |
| Losartan Potassium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-7958 | TABLET, FILM COATED | 25 mg | ORAL | ANDA | 28 sections |
| Losartan Potassium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-7959 | TABLET, FILM COATED | 50 mg | ORAL | ANDA | 28 sections |
| Losartan Potassium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-7960 | TABLET, FILM COATED | 100 mg | ORAL | ANDA | 28 sections |
| Losartan Potassium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-7047 | TABLET, FILM COATED | 25 mg | ORAL | ANDA | 27 sections |
| Losartan Potassium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-7047 | TABLET, FILM COATED | 25 mg | ORAL | ANDA | 27 sections |
| Losartan Potassium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-7048 | TABLET, FILM COATED | 50 mg | ORAL | ANDA | 27 sections |
| Losartan Potassium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-7048 | TABLET, FILM COATED | 50 mg | ORAL | ANDA | 27 sections |
| Losartan Potassium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-7049 | TABLET, FILM COATED | 100 mg | ORAL | ANDA | 27 sections |
| Losartan Potassium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-7049 | TABLET, FILM COATED | 100 mg | ORAL | ANDA | 27 sections |
| LOSARTAN POTASSIUM | Human Prescription Drug Label | 1 | 13107-195 | TABLET | 25 mg | ORAL | ANDA | 27 sections |
| LOSARTAN POTASSIUM | Human Prescription Drug Label | 1 | 13107-196 | TABLET | 50 mg | ORAL | ANDA | 27 sections |
| LOSARTAN POTASSIUM | Human Prescription Drug Label | 1 | 13107-197 | TABLET | 100 mg | ORAL | ANDA | 27 sections |
| Losartan Potassium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-113 | TABLET | 25 mg | ORAL | ANDA | 28 sections |
| Losartan Potassium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-113 | TABLET | 25 mg | ORAL | ANDA | 28 sections |
| Losartan Potassium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-115 | TABLET | 100 mg | ORAL | ANDA | 28 sections |
| Losartan Potassium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-115 | TABLET | 100 mg | ORAL | ANDA | 28 sections |
| Losartan Potassium and Hydrochlorothiazide | HUMAN PRESCRIPTION DRUG LABEL | 2 | 13668-116 | TABLET | 50 mg | ORAL | ANDA | 25 sections |
| Losartan Potassium and Hydrochlorothiazide | HUMAN PRESCRIPTION DRUG LABEL | 2 | 13668-116 | TABLET | 50 mg | ORAL | ANDA | 25 sections |
| Losartan Potassium and Hydrochlorothiazide | HUMAN PRESCRIPTION DRUG LABEL | 2 | 13668-116 | TABLET | 50 mg | ORAL | ANDA | 25 sections |
| Losartan Potassium and Hydrochlorothiazide | HUMAN PRESCRIPTION DRUG LABEL | 2 | 13668-117 | TABLET | 100 mg | ORAL | ANDA | 25 sections |
| Losartan Potassium and Hydrochlorothiazide | HUMAN PRESCRIPTION DRUG LABEL | 2 | 13668-117 | TABLET | 100 mg | ORAL | ANDA | 25 sections |