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2022 Update-Veterinary Drugs & Uses
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Structure 🔎
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L1000
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DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
Search
Structure 🔎
Similarity 🔎
Smart API
Redial
About
Download
L1000
FAQ
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All
FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
tasosartan 🐶
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
angiotensin II receptor antagonists, antihypertensive (non-peptidic)
3839
145733-36-4
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
tasosartan
verdia
ANA756
ANA-756
angiotensin II antagonist; structure given in first source
Molecular weight: 411.47
Formula: C23H21N7O
CLOGP: 2.46
LIPINSKI: 0
HAC: 8
HDO: 1
TPSA: 100.55
ALOGS: -4.10
ROTB: 4
Drug dosage:
None
ADMET properties:
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Property
Value
Reference
BA (Bioavailability)
50 %
Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
BDDCS (Biopharmaceutical Drug Disposition Classification System)
2
Hosey CM, Chan R, Benet LZ
S (Water solubility)
0.03 mg/mL
Bocci G, Oprea TI, Benet LZ
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Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
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Source
Code
Description
ATC
C09CA05
CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), PLAIN
Angiotensin II receptor blockers (ARBs), plain
MeSH PA
D047228
Angiotensin II Type 1 Receptor Blockers
MeSH PA
D057911
Angiotensin Receptor Antagonists
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Drug Use
| Suggest Off label Use Form|
|View source of the data|
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Disease
Relation
SNOMED_ID
DOID
Hypertensive disorder
indication
38341003
DOID:10763
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🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
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Dissociation level
Dissociation constant
Type (acidic/basic)
pKa1
4.25
acidic
pKa2
6.55
Basic
pKa3
0.35
Basic
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Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
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Target
Class
Pharos
UniProt
Action
Type
Activity value
(-log[M])
Mechanism
action
Bioact source
MoA source
Type-1 angiotensin II receptor
GPCR
P30556
AGTR1_HUMAN
ANTAGONIST
IC50
7.49
CHEMBL
SCIENTIFIC LITERATURE
Angiotensin II receptor (AT-1) type-1
GPCR
AGTRA_RAT
AGTRB_RAT
IC50
8.92
CHEMBL
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External reference:
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ID
Source
48G92V856H
UNII
60919
PUBCHEM_CID
6898
IUPHAR_LIGAND_ID
7334
INN_ID
C0662811
UMLSCUI
C086167
MESH_SUPPLEMENTAL_RECORD_UI
CHEBI:135666
CHEBI
CHEMBL432162
ChEMBL_ID
D06010
KEGG_DRUG
DB01349
DRUGBANK_ID
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Pharmaceutical products:
None
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tasosartan