Stem definition | Drug id | CAS RN |
---|---|---|
uridine derivatives used as antiviral agents and as antineoplastics | 1539 | 134678-17-4 |
Dose | Unit | Route |
---|---|---|
0.30 | g | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 3 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 70 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 67 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 21.81 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 86 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 1.30 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 4.80 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.94 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 9.10 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Aug. 8, 1996 | EMA | VIIV HLTHCARE | |
Nov. 17, 1995 | FDA | VIIV HLTHCARE | |
Jan. 14, 2020 | PMDA | ViiV Healthcare K.K. |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Exposure during pregnancy | 2120.41 | 16.30 | 1113 | 26071 | 135229 | 56129654 |
Abortion spontaneous | 1311.70 | 16.30 | 563 | 26621 | 43190 | 56221693 |
Virologic failure | 1281.34 | 16.30 | 268 | 26916 | 1458 | 56263425 |
Viral mutation identified | 1242.77 | 16.30 | 261 | 26923 | 1453 | 56263430 |
Drug resistance | 1091.50 | 16.30 | 400 | 26784 | 20142 | 56244741 |
Stillbirth | 1067.66 | 16.30 | 296 | 26888 | 5918 | 56258965 |
Pathogen resistance | 850.60 | 16.30 | 246 | 26938 | 5754 | 56259129 |
Foetal exposure during pregnancy | 806.29 | 16.30 | 371 | 26813 | 33452 | 56231431 |
Immune reconstitution inflammatory syndrome | 797.06 | 16.30 | 231 | 26953 | 5443 | 56259440 |
Abortion induced | 684.24 | 16.30 | 233 | 26951 | 9412 | 56255471 |
Premature baby | 421.08 | 16.30 | 199 | 26985 | 19006 | 56245877 |
Pregnancy | 360.91 | 16.30 | 215 | 26969 | 32818 | 56232065 |
Blood HIV RNA increased | 346.18 | 16.30 | 76 | 27108 | 536 | 56264347 |
Maternal exposure during pregnancy | 298.18 | 16.30 | 410 | 26774 | 189143 | 56075740 |
Live birth | 296.60 | 16.30 | 158 | 27026 | 19447 | 56245436 |
Caesarean section | 290.38 | 16.30 | 146 | 27038 | 15945 | 56248938 |
Fanconi syndrome acquired | 274.99 | 16.30 | 69 | 27115 | 916 | 56263967 |
Hepatitis B reactivation | 267.73 | 16.30 | 82 | 27102 | 2342 | 56262541 |
Foetal death | 261.53 | 16.30 | 112 | 27072 | 8475 | 56256408 |
Lipodystrophy acquired | 239.15 | 16.30 | 66 | 27118 | 1291 | 56263592 |
Hepatotoxicity | 214.95 | 16.30 | 152 | 27032 | 31001 | 56233882 |
Hepatitis B | 204.93 | 16.30 | 74 | 27110 | 3550 | 56261333 |
Blood bilirubin increased | 192.25 | 16.30 | 146 | 27038 | 33208 | 56231675 |
Treatment noncompliance | 190.69 | 16.30 | 144 | 27040 | 32479 | 56232404 |
Maternal drugs affecting foetus | 187.30 | 16.30 | 76 | 27108 | 5017 | 56259866 |
CD4 lymphocytes decreased | 179.84 | 16.30 | 53 | 27131 | 1322 | 56263561 |
Hypomania | 179.76 | 16.30 | 73 | 27111 | 4829 | 56260054 |
HIV infection | 178.97 | 16.30 | 42 | 27142 | 412 | 56264471 |
Jaundice cholestatic | 171.40 | 16.30 | 73 | 27111 | 5446 | 56259437 |
Premature rupture of membranes | 164.64 | 16.30 | 68 | 27116 | 4697 | 56260186 |
Premature labour | 158.12 | 16.30 | 88 | 27096 | 11794 | 56253089 |
Rheumatoid arthritis | 152.22 | 16.30 | 8 | 27176 | 382596 | 55882287 |
Pain | 138.97 | 16.30 | 74 | 27110 | 663110 | 55601773 |
Schizophrenia | 134.92 | 16.30 | 76 | 27108 | 10423 | 56254460 |
Anaemia | 133.99 | 16.30 | 355 | 26829 | 267156 | 55997727 |
Drug ineffective | 130.51 | 16.30 | 152 | 27032 | 918837 | 55346046 |
Pre-eclampsia | 130.01 | 16.30 | 69 | 27115 | 8417 | 56256466 |
Foetal growth restriction | 126.81 | 16.30 | 64 | 27120 | 7035 | 56257848 |
Mitochondrial toxicity | 126.71 | 16.30 | 31 | 27153 | 368 | 56264515 |
Acquired gene mutation | 123.98 | 16.30 | 36 | 27148 | 851 | 56264032 |
Fatigue | 121.18 | 16.30 | 122 | 27062 | 788430 | 55476453 |
Viral load increased | 119.92 | 16.30 | 38 | 27146 | 1216 | 56263667 |
Human immunodeficiency virus transmission | 117.34 | 16.30 | 21 | 27163 | 39 | 56264844 |
Fanconi syndrome | 114.96 | 16.30 | 37 | 27147 | 1246 | 56263637 |
Hepatitis B DNA increased | 112.45 | 16.30 | 25 | 27159 | 188 | 56264695 |
Joint swelling | 112.31 | 16.30 | 7 | 27177 | 289793 | 55975090 |
Trisomy 21 | 107.54 | 16.30 | 27 | 27157 | 359 | 56264524 |
Lactic acidosis | 102.97 | 16.30 | 105 | 27079 | 35241 | 56229642 |
Nephropathy toxic | 99.59 | 16.30 | 58 | 27126 | 8469 | 56256414 |
Premature delivery | 98.79 | 16.30 | 91 | 27093 | 26969 | 56237914 |
Fall | 97.82 | 16.30 | 26 | 27158 | 357484 | 55907399 |
Lipoatrophy | 97.71 | 16.30 | 24 | 27160 | 290 | 56264593 |
Psychotic disorder | 97.42 | 16.30 | 85 | 27099 | 23473 | 56241410 |
Osteomalacia | 95.51 | 16.30 | 28 | 27156 | 685 | 56264198 |
Hyperbilirubinaemia | 94.79 | 16.30 | 60 | 27124 | 10175 | 56254708 |
Hypophosphataemia | 92.67 | 16.30 | 58 | 27126 | 9644 | 56255239 |
Genotype drug resistance test positive | 88.79 | 16.30 | 23 | 27161 | 349 | 56264534 |
Polydactyly | 87.87 | 16.30 | 22 | 27162 | 289 | 56264594 |
Portal hypertension | 87.83 | 16.30 | 40 | 27144 | 3501 | 56261382 |
Normal newborn | 87.74 | 16.30 | 51 | 27133 | 7419 | 56257464 |
Infusion related reaction | 87.53 | 16.30 | 3 | 27181 | 208928 | 56055955 |
Peripheral swelling | 87.07 | 16.30 | 7 | 27177 | 234719 | 56030164 |
Glycosuria | 86.73 | 16.30 | 29 | 27155 | 1103 | 56263780 |
Proteinuria | 86.27 | 16.30 | 70 | 27114 | 17500 | 56247383 |
Nasopharyngitis | 83.62 | 16.30 | 6 | 27178 | 220953 | 56043930 |
Mitochondrial cytopathy | 83.56 | 16.30 | 20 | 27164 | 215 | 56264668 |
Renal tubular dysfunction | 82.76 | 16.30 | 22 | 27162 | 371 | 56264512 |
Abdominal discomfort | 82.07 | 16.30 | 17 | 27167 | 277257 | 55987626 |
Ventricular septal defect | 81.89 | 16.30 | 40 | 27144 | 4098 | 56260785 |
Off label use | 80.77 | 16.30 | 90 | 27094 | 556090 | 55708793 |
Placental disorder | 79.64 | 16.30 | 29 | 27155 | 1424 | 56263459 |
Congenital umbilical hernia | 77.86 | 16.30 | 20 | 27164 | 293 | 56264590 |
Birth mark | 77.28 | 16.30 | 17 | 27167 | 121 | 56264762 |
Alopecia | 77.15 | 16.30 | 23 | 27161 | 293435 | 55971448 |
Amniotic cavity infection | 76.92 | 16.30 | 27 | 27157 | 1191 | 56263692 |
Ectopic kidney | 76.47 | 16.30 | 15 | 27169 | 55 | 56264828 |
Hyperlactacidaemia | 76.30 | 16.30 | 33 | 27151 | 2555 | 56262328 |
Systemic lupus erythematosus | 73.99 | 16.30 | 3 | 27181 | 180075 | 56084808 |
Alpha 1 foetoprotein abnormal | 72.56 | 16.30 | 14 | 27170 | 46 | 56264837 |
Alanine aminotransferase increased | 71.69 | 16.30 | 147 | 27037 | 93515 | 56171368 |
Product dose omission issue | 70.91 | 16.30 | 8 | 27176 | 204745 | 56060138 |
Hepatomegaly | 70.83 | 16.30 | 52 | 27132 | 11223 | 56253660 |
Premature separation of placenta | 70.72 | 16.30 | 28 | 27156 | 1732 | 56263151 |
CSF HIV escape syndrome | 70.12 | 16.30 | 15 | 27169 | 92 | 56264791 |
Jaundice | 68.66 | 16.30 | 75 | 27109 | 27219 | 56237664 |
Blood lactic acid increased | 67.53 | 16.30 | 40 | 27144 | 6024 | 56258859 |
Small for dates baby | 66.51 | 16.30 | 33 | 27151 | 3497 | 56261386 |
Aspartate aminotransferase increased | 66.01 | 16.30 | 132 | 27052 | 82470 | 56182413 |
Rash maculo-papular | 65.13 | 16.30 | 75 | 27109 | 28832 | 56236051 |
Fat tissue increased | 64.50 | 16.30 | 20 | 27164 | 595 | 56264288 |
Retinoblastoma | 62.77 | 16.30 | 14 | 27170 | 107 | 56264776 |
Oligohydramnios | 62.76 | 16.30 | 38 | 27146 | 5956 | 56258927 |
Cholelithiasis | 62.73 | 16.30 | 86 | 27098 | 39378 | 56225505 |
Congenital anomaly | 62.60 | 16.30 | 25 | 27159 | 1582 | 56263301 |
Ectopic pregnancy | 62.41 | 16.30 | 28 | 27156 | 2366 | 56262517 |
Pulmonary tuberculosis | 61.87 | 16.30 | 34 | 27150 | 4442 | 56260441 |
Hepatic failure | 60.98 | 16.30 | 78 | 27106 | 33408 | 56231475 |
Sinusitis | 60.78 | 16.30 | 11 | 27173 | 197570 | 56067313 |
Arthralgia | 59.68 | 16.30 | 94 | 27090 | 501575 | 55763308 |
Ergot poisoning | 59.66 | 16.30 | 13 | 27171 | 88 | 56264795 |
Drug intolerance | 59.08 | 16.30 | 27 | 27157 | 264791 | 56000092 |
Renal tubular disorder | 58.06 | 16.30 | 27 | 27157 | 2479 | 56262404 |
Swelling | 57.41 | 16.30 | 22 | 27162 | 239749 | 56025134 |
Atrial septal defect | 57.41 | 16.30 | 37 | 27147 | 6469 | 56258414 |
Stevens-Johnson syndrome | 56.52 | 16.30 | 62 | 27122 | 22601 | 56242282 |
Drug interaction | 56.15 | 16.30 | 225 | 26959 | 209530 | 56055353 |
Placental insufficiency | 56.14 | 16.30 | 22 | 27162 | 1324 | 56263559 |
Immune reconstitution inflammatory syndrome associated tuberculosis | 55.80 | 16.30 | 16 | 27168 | 361 | 56264522 |
Lymphadenopathy | 54.87 | 16.30 | 76 | 27108 | 35132 | 56229751 |
Meningitis cryptococcal | 54.20 | 16.30 | 21 | 27163 | 1226 | 56263657 |
Hypertriglyceridaemia | 53.61 | 16.30 | 34 | 27150 | 5782 | 56259101 |
Foetal distress syndrome | 53.51 | 16.30 | 21 | 27163 | 1269 | 56263614 |
Discomfort | 53.18 | 16.30 | 4 | 27180 | 141757 | 56123126 |
Umbilical cord abnormality | 52.08 | 16.30 | 17 | 27167 | 599 | 56264284 |
Malaria | 49.72 | 16.30 | 13 | 27171 | 205 | 56264678 |
Completed suicide | 49.57 | 16.30 | 4 | 27180 | 133829 | 56131054 |
Constipation | 49.22 | 16.30 | 18 | 27166 | 201925 | 56062958 |
Pain in extremity | 47.76 | 16.30 | 44 | 27140 | 297387 | 55967496 |
Hepatitis | 47.18 | 16.30 | 71 | 27113 | 35370 | 56229513 |
Therapeutic product effect decreased | 46.88 | 16.30 | 12 | 27172 | 169440 | 56095443 |
Anaemia macrocytic | 46.87 | 16.30 | 25 | 27159 | 3078 | 56261805 |
Cleft lip and palate | 46.51 | 16.30 | 14 | 27170 | 376 | 56264507 |
Tuberculosis | 46.00 | 16.30 | 40 | 27144 | 10989 | 56253894 |
Ultrasound antenatal screen abnormal | 45.72 | 16.30 | 11 | 27173 | 121 | 56264762 |
Hepatic cytolysis | 44.37 | 16.30 | 39 | 27145 | 10867 | 56254016 |
Meningomyelocele | 44.13 | 16.30 | 15 | 27169 | 600 | 56264283 |
Arnold-Chiari malformation | 43.69 | 16.30 | 15 | 27169 | 619 | 56264264 |
Dyspnoea | 43.65 | 16.30 | 144 | 27040 | 592433 | 55672450 |
Cushing's syndrome | 43.36 | 16.30 | 15 | 27169 | 633 | 56264250 |
Ultrasound scan abnormal | 42.62 | 16.30 | 12 | 27172 | 253 | 56264630 |
Mitochondrial DNA deletion | 42.12 | 16.30 | 7 | 27177 | 6 | 56264877 |
Low birth weight baby | 41.89 | 16.30 | 30 | 27154 | 6228 | 56258655 |
Necrotising colitis | 41.73 | 16.30 | 14 | 27170 | 538 | 56264345 |
Pericarditis | 41.05 | 16.30 | 3 | 27181 | 108920 | 56155963 |
Ocular icterus | 41.02 | 16.30 | 24 | 27160 | 3532 | 56261351 |
Blood bilirubin unconjugated increased | 40.38 | 16.30 | 12 | 27172 | 308 | 56264575 |
Hydrops foetalis | 39.64 | 16.30 | 13 | 27171 | 465 | 56264418 |
Drug hypersensitivity | 39.31 | 16.30 | 45 | 27139 | 275160 | 55989723 |
Macrocephaly | 39.24 | 16.30 | 9 | 27175 | 79 | 56264804 |
Patent ductus arteriosus | 38.69 | 16.30 | 24 | 27160 | 3927 | 56260956 |
Rickets | 38.45 | 16.30 | 8 | 27176 | 42 | 56264841 |
Headache | 37.69 | 16.30 | 141 | 27043 | 558903 | 55705980 |
Neonatal disorder | 37.57 | 16.30 | 13 | 27171 | 549 | 56264334 |
Cleft palate | 37.25 | 16.30 | 15 | 27169 | 970 | 56263913 |
Contusion | 35.70 | 16.30 | 9 | 27175 | 128421 | 56136462 |
Tuberculoma of central nervous system | 35.64 | 16.30 | 11 | 27173 | 322 | 56264561 |
Gestational diabetes | 35.16 | 16.30 | 30 | 27154 | 8034 | 56256849 |
Pregnancy on contraceptive | 35.07 | 16.30 | 15 | 27169 | 1130 | 56263753 |
Gene mutation | 34.78 | 16.30 | 16 | 27168 | 1433 | 56263450 |
Product use issue | 34.24 | 16.30 | 24 | 27160 | 186017 | 56078866 |
Hypouricaemia | 34.24 | 16.30 | 9 | 27175 | 145 | 56264738 |
CD4 lymphocytes increased | 34.18 | 16.30 | 9 | 27175 | 146 | 56264737 |
Metabolic acidosis | 33.93 | 16.30 | 66 | 27118 | 40388 | 56224495 |
Multiple-drug resistance | 33.59 | 16.30 | 22 | 27162 | 3952 | 56260931 |
Weight increased | 33.40 | 16.30 | 37 | 27147 | 229666 | 56035217 |
Isosporiasis | 33.00 | 16.30 | 7 | 27177 | 41 | 56264842 |
Hepatitis A | 32.78 | 16.30 | 11 | 27173 | 423 | 56264460 |
Neutropenia | 32.62 | 16.30 | 157 | 27027 | 158010 | 56106873 |
AIDS cholangiopathy | 32.31 | 16.30 | 6 | 27178 | 15 | 56264868 |
Neural tube defect | 31.91 | 16.30 | 9 | 27175 | 191 | 56264692 |
Placental infarction | 31.73 | 16.30 | 10 | 27174 | 314 | 56264569 |
Cardiac murmur | 31.61 | 16.30 | 33 | 27151 | 11368 | 56253515 |
Atrial fibrillation | 31.51 | 16.30 | 7 | 27177 | 108890 | 56155993 |
Cardiac malposition | 31.44 | 16.30 | 7 | 27177 | 53 | 56264830 |
Benign hydatidiform mole | 31.41 | 16.30 | 8 | 27176 | 113 | 56264770 |
Hydrocephalus | 31.31 | 16.30 | 23 | 27161 | 4966 | 56259917 |
Back pain | 30.50 | 16.30 | 42 | 27142 | 237128 | 56027755 |
HIV-associated neurocognitive disorder | 30.31 | 16.30 | 8 | 27176 | 131 | 56264752 |
Renal tubular acidosis | 30.31 | 16.30 | 15 | 27169 | 1580 | 56263303 |
Influenza | 29.94 | 16.30 | 5 | 27179 | 95256 | 56169627 |
Hepatosplenomegaly | 29.60 | 16.30 | 17 | 27167 | 2416 | 56262467 |
Spina bifida | 29.51 | 16.30 | 12 | 27172 | 796 | 56264087 |
Infection | 29.38 | 16.30 | 32 | 27152 | 200174 | 56064709 |
Asthma | 29.29 | 16.30 | 9 | 27175 | 112761 | 56152122 |
Pruritus | 29.13 | 16.30 | 69 | 27115 | 316554 | 55948329 |
Neutropenia neonatal | 29.10 | 16.30 | 7 | 27177 | 77 | 56264806 |
Gamma-glutamyltransferase increased | 29.00 | 16.30 | 53 | 27131 | 30952 | 56233931 |
Chronic disease | 28.85 | 16.30 | 7 | 27177 | 80 | 56264803 |
Twin pregnancy | 28.84 | 16.30 | 13 | 27171 | 1110 | 56263773 |
Lymphadenitis | 28.84 | 16.30 | 18 | 27166 | 2977 | 56261906 |
Psoriasis | 28.83 | 16.30 | 5 | 27179 | 92687 | 56172196 |
Bilirubin conjugated increased | 28.72 | 16.30 | 17 | 27167 | 2556 | 56262327 |
Drug reaction with eosinophilia and systemic symptoms | 28.59 | 16.30 | 52 | 27132 | 30252 | 56234631 |
Dyslipidaemia | 28.45 | 16.30 | 24 | 27160 | 6329 | 56258554 |
Ballismus | 28.31 | 16.30 | 7 | 27177 | 87 | 56264796 |
Postpartum haemorrhage | 28.22 | 16.30 | 15 | 27169 | 1834 | 56263049 |
Prenatal screening test abnormal | 28.04 | 16.30 | 5 | 27179 | 9 | 56264874 |
Isoimmune haemolytic disease | 28.02 | 16.30 | 6 | 27178 | 37 | 56264846 |
Gestational hypertension | 27.80 | 16.30 | 16 | 27168 | 2283 | 56262600 |
Blister | 27.73 | 16.30 | 9 | 27175 | 108878 | 56156005 |
Hydromyelia | 27.69 | 16.30 | 5 | 27179 | 10 | 56264873 |
Feeling abnormal | 27.68 | 16.30 | 15 | 27169 | 133587 | 56131296 |
Ascites | 27.61 | 16.30 | 58 | 27126 | 37486 | 56227397 |
Musculoskeletal stiffness | 27.57 | 16.30 | 21 | 27163 | 155986 | 56108897 |
Double outlet right ventricle | 27.49 | 16.30 | 6 | 27178 | 41 | 56264842 |
Infertility | 27.10 | 16.30 | 11 | 27173 | 726 | 56264157 |
Anembryonic gestation | 26.71 | 16.30 | 10 | 27174 | 531 | 56264352 |
Foetal growth abnormality | 26.55 | 16.30 | 6 | 27178 | 49 | 56264834 |
Bicuspid pulmonary valve | 26.55 | 16.30 | 4 | 27180 | 0 | 56264883 |
Hepatitis B surface antigen positive | 26.44 | 16.30 | 6 | 27178 | 50 | 56264833 |
Vomiting | 26.34 | 16.30 | 361 | 26823 | 497867 | 55767016 |
Lymph node tuberculosis | 26.28 | 16.30 | 11 | 27173 | 785 | 56264098 |
Funisitis | 26.01 | 16.30 | 5 | 27179 | 16 | 56264867 |
Cerebral toxoplasmosis | 25.89 | 16.30 | 11 | 27173 | 815 | 56264068 |
Diarrhoea | 25.64 | 16.30 | 192 | 26992 | 638315 | 55626568 |
Cholestatic liver injury | 25.45 | 16.30 | 15 | 27169 | 2237 | 56262646 |
Transaminases increased | 25.43 | 16.30 | 48 | 27136 | 28722 | 56236161 |
Malignant neoplasm progression | 25.14 | 16.30 | 3 | 27181 | 73584 | 56191299 |
Lower respiratory tract infection | 25.11 | 16.30 | 12 | 27172 | 114782 | 56150101 |
Blood pressure increased | 25.07 | 16.30 | 20 | 27164 | 145156 | 56119727 |
Retinal toxicity | 24.99 | 16.30 | 12 | 27172 | 1184 | 56263699 |
Micrognathia | 24.95 | 16.30 | 8 | 27176 | 266 | 56264617 |
Muscle spasms | 24.90 | 16.30 | 18 | 27166 | 137353 | 56127530 |
Ovarian failure | 24.90 | 16.30 | 12 | 27172 | 1193 | 56263690 |
Eyelid oedema | 24.83 | 16.30 | 27 | 27157 | 9741 | 56255142 |
Renal failure | 24.46 | 16.30 | 112 | 27072 | 110388 | 56154495 |
Neonatal aspiration | 24.45 | 16.30 | 7 | 27177 | 157 | 56264726 |
Fat redistribution | 24.31 | 16.30 | 4 | 27180 | 3 | 56264880 |
Acquired aminoaciduria | 24.31 | 16.30 | 4 | 27180 | 3 | 56264880 |
Abortion missed | 24.29 | 16.30 | 13 | 27171 | 1611 | 56263272 |
Kaposi's sarcoma | 24.29 | 16.30 | 7 | 27177 | 161 | 56264722 |
Migraine | 24.28 | 16.30 | 6 | 27178 | 86791 | 56178092 |
Foetal anaemia | 24.24 | 16.30 | 6 | 27178 | 75 | 56264808 |
Hypophosphataemic osteomalacia | 24.12 | 16.30 | 7 | 27177 | 165 | 56264718 |
Hyperphosphaturia | 24.07 | 16.30 | 5 | 27179 | 26 | 56264857 |
Alpha 1 foetoprotein increased | 24.04 | 16.30 | 7 | 27177 | 167 | 56264716 |
Fallot's tetralogy | 23.95 | 16.30 | 6 | 27178 | 79 | 56264804 |
Hepatic displacement | 23.91 | 16.30 | 5 | 27179 | 27 | 56264856 |
Hepatic enzyme increased | 23.87 | 16.30 | 153 | 27031 | 171231 | 56093652 |
Cytomegalovirus chorioretinitis | 23.75 | 16.30 | 13 | 27171 | 1685 | 56263198 |
Anaemia neonatal | 23.35 | 16.30 | 8 | 27176 | 328 | 56264555 |
Hepatitis B DNA assay positive | 23.33 | 16.30 | 5 | 27179 | 31 | 56264852 |
Death neonatal | 23.24 | 16.30 | 10 | 27174 | 764 | 56264119 |
Haemorrhage in pregnancy | 23.20 | 16.30 | 13 | 27171 | 1763 | 56263120 |
Necrotising enterocolitis neonatal | 23.19 | 16.30 | 7 | 27177 | 190 | 56264693 |
Lipase increased | 23.14 | 16.30 | 25 | 27159 | 8954 | 56255929 |
Cachexia | 22.81 | 16.30 | 19 | 27165 | 4923 | 56259960 |
Neonatal respiratory distress syndrome | 22.68 | 16.30 | 15 | 27169 | 2739 | 56262144 |
Diastasis recti abdominis | 22.56 | 16.30 | 5 | 27179 | 37 | 56264846 |
AIDS related complication | 22.50 | 16.30 | 4 | 27180 | 7 | 56264876 |
Blood creatine phosphokinase MB increased | 22.23 | 16.30 | 11 | 27173 | 1158 | 56263725 |
Respiratory distress | 22.22 | 16.30 | 48 | 27136 | 31619 | 56233264 |
Type III hyperlipidaemia | 22.15 | 16.30 | 4 | 27180 | 8 | 56264875 |
Anxiety | 22.13 | 16.30 | 37 | 27147 | 193135 | 56071748 |
Cholestasis of pregnancy | 22.13 | 16.30 | 11 | 27173 | 1170 | 56263713 |
Dizziness | 22.08 | 16.30 | 100 | 27084 | 376040 | 55888843 |
Loss of personal independence in daily activities | 22.04 | 16.30 | 6 | 27178 | 81363 | 56183520 |
Breech delivery | 22.00 | 16.30 | 5 | 27179 | 42 | 56264841 |
Lipohypertrophy | 21.87 | 16.30 | 9 | 27175 | 615 | 56264268 |
Blood creatine phosphokinase increased | 21.51 | 16.30 | 44 | 27140 | 27908 | 56236975 |
Aminoaciduria | 21.42 | 16.30 | 6 | 27178 | 124 | 56264759 |
Dyschezia | 21.39 | 16.30 | 13 | 27171 | 2050 | 56262833 |
COVID-19 | 21.36 | 16.30 | 5 | 27179 | 75053 | 56189830 |
Fontanelle bulging | 21.26 | 16.30 | 4 | 27180 | 11 | 56264872 |
Antiviral drug level below therapeutic | 21.13 | 16.30 | 5 | 27179 | 51 | 56264832 |
Placenta praevia | 20.98 | 16.30 | 10 | 27174 | 970 | 56263913 |
Pallor | 20.98 | 16.30 | 40 | 27144 | 24109 | 56240774 |
Malaise | 20.88 | 16.30 | 99 | 27085 | 367761 | 55897122 |
Gastroschisis | 20.86 | 16.30 | 7 | 27177 | 269 | 56264614 |
Urinary tract infection | 20.86 | 16.30 | 54 | 27130 | 240459 | 56024424 |
Pubertal failure | 20.76 | 16.30 | 4 | 27180 | 13 | 56264870 |
Pleocytosis | 20.62 | 16.30 | 9 | 27175 | 712 | 56264171 |
Bovine tuberculosis | 20.62 | 16.30 | 5 | 27179 | 57 | 56264826 |
Developmental delay | 20.57 | 16.30 | 11 | 27173 | 1361 | 56263522 |
Breast neoplasm | 20.54 | 16.30 | 11 | 27173 | 1365 | 56263518 |
Myopathy toxic | 20.53 | 16.30 | 8 | 27176 | 474 | 56264409 |
CSF protein increased | 20.52 | 16.30 | 8 | 27176 | 475 | 56264408 |
Ventricular hypoplasia | 20.42 | 16.30 | 6 | 27178 | 148 | 56264735 |
Therapeutic product effect incomplete | 20.41 | 16.30 | 13 | 27171 | 106018 | 56158865 |
Congenital hydrocephalus | 20.34 | 16.30 | 6 | 27178 | 150 | 56264733 |
Spinal cord injury | 20.29 | 16.30 | 9 | 27175 | 740 | 56264143 |
Carnitine deficiency | 20.19 | 16.30 | 6 | 27178 | 154 | 56264729 |
Osteoporosis | 20.05 | 16.30 | 63 | 27121 | 51989 | 56212894 |
Vertical infection transmission | 19.91 | 16.30 | 3 | 27181 | 0 | 56264883 |
Pharyngotonsillitis | 19.87 | 16.30 | 6 | 27178 | 163 | 56264720 |
Social avoidant behaviour | 19.85 | 16.30 | 14 | 27170 | 2838 | 56262045 |
Osteoarthritis | 19.81 | 16.30 | 7 | 27177 | 80289 | 56184594 |
Renal glycosuria | 19.74 | 16.30 | 4 | 27180 | 18 | 56264865 |
Ebstein's anomaly | 19.74 | 16.30 | 4 | 27180 | 18 | 56264865 |
Amenorrhoea | 19.70 | 16.30 | 23 | 27161 | 8963 | 56255920 |
Influenza like illness | 19.61 | 16.30 | 3 | 27181 | 60985 | 56203898 |
Varices oesophageal | 19.57 | 16.30 | 14 | 27170 | 2902 | 56261981 |
Portal vein thrombosis | 19.48 | 16.30 | 13 | 27171 | 2410 | 56262473 |
Meningitis tuberculous | 19.37 | 16.30 | 8 | 27176 | 552 | 56264331 |
Eclampsia | 19.33 | 16.30 | 7 | 27177 | 338 | 56264545 |
Insomnia | 19.10 | 16.30 | 40 | 27144 | 191820 | 56073063 |
Congenital intestinal malformation | 19.07 | 16.30 | 4 | 27180 | 22 | 56264861 |
Pulmonary artery atresia | 19.07 | 16.30 | 4 | 27180 | 22 | 56264861 |
Thyroid tuberculosis | 19.07 | 16.30 | 4 | 27180 | 22 | 56264861 |
Hypotension | 18.97 | 16.30 | 60 | 27124 | 250448 | 56014435 |
Diaphragmatic aplasia | 18.92 | 16.30 | 4 | 27180 | 23 | 56264860 |
Acquired immunodeficiency syndrome | 18.88 | 16.30 | 5 | 27179 | 83 | 56264800 |
Disseminated Bacillus Calmette-Guerin infection | 18.77 | 16.30 | 4 | 27180 | 24 | 56264859 |
Aqueductal stenosis | 18.77 | 16.30 | 4 | 27180 | 24 | 56264859 |
Hemiataxia | 18.77 | 16.30 | 4 | 27180 | 24 | 56264859 |
Blood alkaline phosphatase increased | 18.70 | 16.30 | 51 | 27133 | 38894 | 56225989 |
Placental necrosis | 18.50 | 16.30 | 4 | 27180 | 26 | 56264857 |
Blood cholesterol increased | 18.48 | 16.30 | 6 | 27178 | 72573 | 56192310 |
Lactate pyruvate ratio increased | 18.45 | 16.30 | 5 | 27179 | 91 | 56264792 |
Myelopathy | 18.43 | 16.30 | 13 | 27171 | 2635 | 56262248 |
Pyrexia | 18.39 | 16.30 | 294 | 26890 | 418479 | 55846404 |
HELLP syndrome | 18.38 | 16.30 | 9 | 27175 | 927 | 56263956 |
Acute stress disorder | 18.26 | 16.30 | 6 | 27178 | 216 | 56264667 |
Secondary hypogonadism | 18.01 | 16.30 | 5 | 27179 | 100 | 56264783 |
Delayed puberty | 17.87 | 16.30 | 5 | 27179 | 103 | 56264780 |
Cervix operation | 17.83 | 16.30 | 3 | 27181 | 3 | 56264880 |
Oxygen saturation decreased | 17.70 | 16.30 | 8 | 27176 | 79059 | 56185824 |
Nasal congestion | 17.62 | 16.30 | 3 | 27181 | 56367 | 56208516 |
Death | 17.59 | 16.30 | 95 | 27089 | 341331 | 55923552 |
Mycobacterium avium complex infection | 17.49 | 16.30 | 13 | 27171 | 2856 | 56262027 |
Cryptococcosis | 17.43 | 16.30 | 9 | 27175 | 1037 | 56263846 |
Cervical dysplasia | 17.37 | 16.30 | 13 | 27171 | 2888 | 56261995 |
Cleft lip | 17.19 | 16.30 | 5 | 27179 | 119 | 56264764 |
Developmental coordination disorder | 17.16 | 16.30 | 4 | 27180 | 38 | 56264845 |
Persistent left superior vena cava | 17.16 | 16.30 | 4 | 27180 | 38 | 56264845 |
Hepatitis C | 17.00 | 16.30 | 17 | 27167 | 5569 | 56259314 |
Genital prolapse | 16.97 | 16.30 | 4 | 27180 | 40 | 56264843 |
Musculoskeletal pain | 16.97 | 16.30 | 9 | 27175 | 81143 | 56183740 |
Fibromyalgia | 16.90 | 16.30 | 4 | 27180 | 59599 | 56205284 |
Intentional product use issue | 16.89 | 16.30 | 14 | 27170 | 99719 | 56165164 |
Acute fatty liver of pregnancy | 16.71 | 16.30 | 4 | 27180 | 43 | 56264840 |
Intentional overdose | 16.70 | 16.30 | 6 | 27178 | 68111 | 56196772 |
Anaphylactic reaction | 16.65 | 16.30 | 4 | 27180 | 58991 | 56205892 |
Infected vasculitis | 16.62 | 16.30 | 3 | 27181 | 6 | 56264877 |
Carbon dioxide combining power abnormal | 16.62 | 16.30 | 3 | 27181 | 6 | 56264877 |
Glycocholic acid increased | 16.62 | 16.30 | 3 | 27181 | 6 | 56264877 |
Growth hormone-producing pituitary tumour | 16.62 | 16.30 | 3 | 27181 | 6 | 56264877 |
Threatened labour | 16.60 | 16.30 | 8 | 27176 | 795 | 56264088 |
Oropharyngeal pain | 16.50 | 16.30 | 10 | 27174 | 83778 | 56181105 |
Bronchitis | 16.41 | 16.30 | 18 | 27166 | 112293 | 56152590 |
Foetal heart rate abnormal | 16.35 | 16.30 | 7 | 27177 | 528 | 56264355 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Viral mutation identified | 1819.51 | 12.46 | 481 | 46250 | 2288 | 31648325 |
Virologic failure | 1544.39 | 12.46 | 435 | 46296 | 2730 | 31647883 |
Immune reconstitution inflammatory syndrome | 1520.48 | 12.46 | 538 | 46193 | 7640 | 31642973 |
Pathogen resistance | 1357.90 | 12.46 | 503 | 46228 | 8198 | 31642415 |
Drug resistance | 967.68 | 12.46 | 535 | 46196 | 22918 | 31627695 |
Lipodystrophy acquired | 822.94 | 12.46 | 270 | 46461 | 2994 | 31647619 |
Foetal exposure during pregnancy | 733.45 | 12.46 | 552 | 46179 | 40324 | 31610289 |
Hepatitis B | 728.14 | 12.46 | 286 | 46445 | 5495 | 31645118 |
Drug interaction | 667.56 | 12.46 | 1139 | 45592 | 207404 | 31443209 |
Depression | 654.39 | 12.46 | 735 | 45996 | 90080 | 31560533 |
Exposure during pregnancy | 563.12 | 12.46 | 268 | 46463 | 8330 | 31642283 |
Mitochondrial toxicity | 491.97 | 12.46 | 173 | 46558 | 2400 | 31648213 |
Hepatitis B reactivation | 366.85 | 12.46 | 152 | 46579 | 3366 | 31647247 |
Hepatitis B DNA increased | 361.40 | 12.46 | 95 | 46636 | 438 | 31650175 |
Osteomalacia | 355.41 | 12.46 | 105 | 46626 | 795 | 31649818 |
Acquired gene mutation | 315.82 | 12.46 | 105 | 46626 | 1215 | 31649398 |
Eyelid ptosis | 314.84 | 12.46 | 156 | 46575 | 5299 | 31645314 |
Fanconi syndrome acquired | 283.15 | 12.46 | 106 | 46625 | 1774 | 31648839 |
Viral load increased | 270.97 | 12.46 | 107 | 46624 | 2082 | 31648531 |
Blood HIV RNA increased | 249.45 | 12.46 | 85 | 46646 | 1066 | 31649547 |
Progressive external ophthalmoplegia | 229.81 | 12.46 | 84 | 46647 | 1310 | 31649303 |
Lipoatrophy | 210.12 | 12.46 | 61 | 46670 | 431 | 31650182 |
Pinealoblastoma | 205.14 | 12.46 | 49 | 46682 | 138 | 31650475 |
Premature baby | 192.74 | 12.46 | 181 | 46550 | 17885 | 31632728 |
Hypertriglyceridaemia | 192.12 | 12.46 | 128 | 46603 | 7670 | 31642943 |
Diplopia | 186.92 | 12.46 | 160 | 46571 | 14002 | 31636611 |
Hypophosphataemia | 186.59 | 12.46 | 130 | 46601 | 8384 | 31642229 |
Hepatic failure | 177.93 | 12.46 | 230 | 46501 | 32472 | 31618141 |
HIV infection | 172.28 | 12.46 | 71 | 46660 | 1549 | 31649064 |
Fanconi syndrome | 163.81 | 12.46 | 69 | 46662 | 1593 | 31649020 |
Multiple-drug resistance | 162.30 | 12.46 | 94 | 46637 | 4386 | 31646227 |
Genotype drug resistance test | 155.62 | 12.46 | 33 | 46698 | 41 | 31650572 |
CD4 lymphocytes decreased | 153.29 | 12.46 | 66 | 46665 | 1611 | 31649002 |
Renal tubular disorder | 153.08 | 12.46 | 90 | 46641 | 4320 | 31646293 |
Kaposi's sarcoma | 152.29 | 12.46 | 55 | 46676 | 827 | 31649786 |
Hepatic fibrosis | 147.60 | 12.46 | 84 | 46647 | 3790 | 31646823 |
Polydactyly | 143.01 | 12.46 | 57 | 46674 | 1137 | 31649476 |
Off label use | 139.82 | 12.46 | 185 | 46546 | 347089 | 31303524 |
Gene mutation | 133.36 | 12.46 | 54 | 46677 | 1124 | 31649489 |
Trisomy 21 | 131.02 | 12.46 | 44 | 46687 | 526 | 31650087 |
Loss of personal independence in daily activities | 129.55 | 12.46 | 183 | 46548 | 28105 | 31622508 |
Osteoporosis | 119.61 | 12.46 | 114 | 46617 | 11469 | 31639144 |
Alanine aminotransferase increased | 118.40 | 12.46 | 307 | 46424 | 74349 | 31576264 |
Meningitis cryptococcal | 115.26 | 12.46 | 60 | 46671 | 2263 | 31648350 |
Treatment failure | 114.23 | 12.46 | 211 | 46520 | 40581 | 31610032 |
Portal hypertension | 113.70 | 12.46 | 70 | 46661 | 3655 | 31646958 |
Retinal toxicity | 109.90 | 12.46 | 36 | 46695 | 396 | 31650217 |
HIV-associated neurocognitive disorder | 105.98 | 12.46 | 33 | 46698 | 304 | 31650309 |
Maternal drugs affecting foetus | 105.73 | 12.46 | 68 | 46663 | 3835 | 31646778 |
Treatment noncompliance | 101.47 | 12.46 | 155 | 46576 | 25529 | 31625084 |
Product dose omission issue | 99.04 | 12.46 | 18 | 46713 | 105568 | 31545045 |
Fall | 97.41 | 12.46 | 79 | 46652 | 186010 | 31464603 |
Blood lactic acid increased | 94.92 | 12.46 | 76 | 46655 | 6054 | 31644559 |
Volvulus | 94.80 | 12.46 | 43 | 46688 | 1192 | 31649421 |
Blood phosphorus decreased | 93.67 | 12.46 | 57 | 46674 | 2914 | 31647699 |
Mycobacterium avium complex infection | 93.48 | 12.46 | 53 | 46678 | 2373 | 31648240 |
Hyperlactacidaemia | 92.50 | 12.46 | 55 | 46676 | 2695 | 31647918 |
Osteonecrosis | 92.18 | 12.46 | 108 | 46623 | 13776 | 31636837 |
Nephropathy toxic | 92.01 | 12.46 | 98 | 46633 | 11255 | 31639358 |
Completed suicide | 91.66 | 12.46 | 13 | 46718 | 91501 | 31559112 |
CSF HIV escape syndrome | 89.63 | 12.46 | 26 | 46705 | 183 | 31650430 |
Hepatic cirrhosis | 89.55 | 12.46 | 113 | 46618 | 15561 | 31635052 |
Acquired immunodeficiency syndrome | 89.22 | 12.46 | 32 | 46699 | 471 | 31650142 |
Jaundice | 89.00 | 12.46 | 160 | 46571 | 30127 | 31620486 |
Cytomegalovirus chorioretinitis | 88.62 | 12.46 | 58 | 46673 | 3370 | 31647243 |
Pneumonia | 88.35 | 12.46 | 231 | 46500 | 335081 | 31315532 |
Mitochondrial cytopathy | 84.25 | 12.46 | 24 | 46707 | 157 | 31650456 |
Renal tubular dysfunction | 83.45 | 12.46 | 29 | 46702 | 387 | 31650226 |
Drug abuse | 82.20 | 12.46 | 15 | 46716 | 87743 | 31562870 |
Hyperlipidaemia | 81.82 | 12.46 | 99 | 46632 | 13061 | 31637552 |
Death | 80.79 | 12.46 | 268 | 46463 | 360301 | 31290312 |
Dyspnoea | 80.64 | 12.46 | 250 | 46481 | 343229 | 31307384 |
Peripheral swelling | 80.17 | 12.46 | 5 | 46726 | 67860 | 31582753 |
Hypouricaemia | 79.83 | 12.46 | 25 | 46706 | 235 | 31650378 |
Aspartate aminotransferase increased | 79.71 | 12.46 | 238 | 46493 | 62481 | 31588132 |
Hepatitis C | 76.14 | 12.46 | 86 | 46645 | 10544 | 31640069 |
Hypotension | 76.14 | 12.46 | 115 | 46616 | 204503 | 31446110 |
Drug-induced liver injury | 75.82 | 12.46 | 132 | 46599 | 24231 | 31626382 |
Neonatal disorder | 74.58 | 12.46 | 32 | 46699 | 774 | 31649839 |
Varices oesophageal | 72.81 | 12.46 | 51 | 46680 | 3315 | 31647298 |
Progressive multifocal leukoencephalopathy | 71.97 | 12.46 | 78 | 46653 | 9135 | 31641478 |
Ophthalmoplegia | 71.86 | 12.46 | 40 | 46691 | 1728 | 31648885 |
Psychiatric decompensation | 70.35 | 12.46 | 41 | 46690 | 1935 | 31648678 |
Proteinuria | 70.23 | 12.46 | 104 | 46627 | 16659 | 31633954 |
Fatigue | 69.76 | 12.46 | 257 | 46474 | 334949 | 31315664 |
Hepatitis | 69.25 | 12.46 | 120 | 46611 | 21946 | 31628667 |
Caesarean section | 68.47 | 12.46 | 40 | 46691 | 1896 | 31648717 |
Lymphadenopathy | 67.98 | 12.46 | 131 | 46600 | 25990 | 31624623 |
Dyslipidaemia | 67.94 | 12.46 | 64 | 46667 | 6342 | 31644271 |
Pulmonary tuberculosis | 67.86 | 12.46 | 56 | 46675 | 4655 | 31645958 |
Dandy-Walker syndrome | 67.77 | 12.46 | 21 | 46710 | 190 | 31650423 |
Hepatomegaly | 66.26 | 12.46 | 76 | 46655 | 9474 | 31641139 |
Pain | 65.63 | 12.46 | 109 | 46622 | 186650 | 31463963 |
Anaemia macrocytic | 65.21 | 12.46 | 45 | 46686 | 2855 | 31647758 |
Renal impairment | 65.12 | 12.46 | 276 | 46455 | 86073 | 31564540 |
Lactic acidosis | 64.16 | 12.46 | 144 | 46587 | 31793 | 31618820 |
Blood alkaline phosphatase increased | 63.93 | 12.46 | 137 | 46594 | 29316 | 31621297 |
Glycosuria | 62.43 | 12.46 | 32 | 46699 | 1168 | 31649445 |
Constipation | 61.92 | 12.46 | 55 | 46676 | 123936 | 31526677 |
Hepatic function abnormal | 61.70 | 12.46 | 166 | 46565 | 41056 | 31609557 |
Malignant neoplasm progression | 61.33 | 12.46 | 20 | 46711 | 78978 | 31571635 |
Hyperbilirubinaemia | 60.71 | 12.46 | 94 | 46637 | 15656 | 31634957 |
Congenital umbilical hernia | 60.65 | 12.46 | 21 | 46710 | 277 | 31650336 |
Blood pressure increased | 60.36 | 12.46 | 21 | 46710 | 79612 | 31571001 |
Oesophageal candidiasis | 59.85 | 12.46 | 49 | 46682 | 4028 | 31646585 |
Birth mark | 59.29 | 12.46 | 18 | 46713 | 151 | 31650462 |
Congenital anomaly | 59.21 | 12.46 | 32 | 46699 | 1303 | 31649310 |
Urine phosphorus increased | 58.20 | 12.46 | 14 | 46717 | 41 | 31650572 |
Tuberculosis | 57.23 | 12.46 | 66 | 46665 | 8275 | 31642338 |
Blood bilirubin increased | 56.15 | 12.46 | 145 | 46586 | 34991 | 31615622 |
Atrial fibrillation | 53.83 | 12.46 | 53 | 46678 | 113730 | 31536883 |
Lipohypertrophy | 51.54 | 12.46 | 18 | 46713 | 244 | 31650369 |
Pregnancy | 51.34 | 12.46 | 18 | 46713 | 247 | 31650366 |
Hepatosplenomegaly | 50.89 | 12.46 | 44 | 46687 | 3899 | 31646714 |
Blood triglycerides increased | 50.30 | 12.46 | 79 | 46652 | 13318 | 31637295 |
Atrioventricular septal defect | 50.19 | 12.46 | 17 | 46714 | 209 | 31650404 |
Calculus urinary | 49.74 | 12.46 | 28 | 46703 | 1236 | 31649377 |
Talipes | 49.60 | 12.46 | 32 | 46699 | 1814 | 31648799 |
Inappropriate schedule of product administration | 49.08 | 12.46 | 8 | 46723 | 50815 | 31599798 |
Human immunodeficiency virus transmission | 48.35 | 12.46 | 11 | 46720 | 23 | 31650590 |
Depressive symptom | 48.00 | 12.46 | 33 | 46698 | 2081 | 31648532 |
Genotype drug resistance test positive | 47.75 | 12.46 | 26 | 46705 | 1075 | 31649538 |
CD4 lymphocytes increased | 46.49 | 12.46 | 16 | 46715 | 207 | 31650406 |
Plasma cell myeloma | 46.24 | 12.46 | 13 | 46718 | 56518 | 31594095 |
Nasopharyngitis | 45.70 | 12.46 | 18 | 46713 | 63227 | 31587386 |
Nodular regenerative hyperplasia | 45.55 | 12.46 | 24 | 46707 | 928 | 31649685 |
Congenital central nervous system anomaly | 45.53 | 12.46 | 20 | 46711 | 513 | 31650100 |
Infusion related reaction | 45.44 | 12.46 | 8 | 46723 | 48047 | 31602566 |
Hepatocellular carcinoma | 45.12 | 12.46 | 60 | 46671 | 8696 | 31641917 |
Pyelocaliectasis | 44.78 | 12.46 | 25 | 46706 | 1086 | 31649527 |
Gamma-glutamyltransferase increased | 44.63 | 12.46 | 115 | 46616 | 27710 | 31622903 |
Cachexia | 44.40 | 12.46 | 52 | 46679 | 6627 | 31643986 |
Hepatic cancer | 44.32 | 12.46 | 56 | 46675 | 7719 | 31642894 |
Facial wasting | 44.20 | 12.46 | 14 | 46717 | 137 | 31650476 |
Hepatitis B virus test | 44.17 | 12.46 | 8 | 46723 | 0 | 31650613 |
Hepatic encephalopathy | 43.74 | 12.46 | 75 | 46656 | 13596 | 31637017 |
Oesophageal varices haemorrhage | 43.30 | 12.46 | 35 | 46696 | 2825 | 31647788 |
Multiple fractures | 43.04 | 12.46 | 26 | 46705 | 1311 | 31649302 |
Cryptococcosis | 42.76 | 12.46 | 32 | 46699 | 2306 | 31648307 |
Optic nerve neoplasm | 42.44 | 12.46 | 10 | 46721 | 26 | 31650587 |
Opportunistic infection | 42.30 | 12.46 | 27 | 46704 | 1502 | 31649111 |
Splenomegaly | 42.13 | 12.46 | 74 | 46657 | 13675 | 31636938 |
Anaemia neonatal | 42.07 | 12.46 | 16 | 46715 | 280 | 31650333 |
Immune reconstitution inflammatory syndrome associated tuberculosis | 41.70 | 12.46 | 18 | 46713 | 442 | 31650171 |
Congenital neoplasm | 41.39 | 12.46 | 10 | 46721 | 30 | 31650583 |
Blood bilirubin unconjugated increased | 41.25 | 12.46 | 19 | 46712 | 546 | 31650067 |
Oral candidiasis | 41.14 | 12.46 | 65 | 46666 | 11012 | 31639601 |
Joint swelling | 40.63 | 12.46 | 14 | 46717 | 53417 | 31597196 |
Basedow's disease | 40.62 | 12.46 | 11 | 46720 | 58 | 31650555 |
Depression suicidal | 40.57 | 12.46 | 27 | 46704 | 1613 | 31649000 |
Cryptorchism | 40.42 | 12.46 | 29 | 46702 | 1958 | 31648655 |
Brain stem stroke | 39.84 | 12.46 | 15 | 46716 | 255 | 31650358 |
Pneumocystis jirovecii pneumonia | 39.72 | 12.46 | 85 | 46646 | 18166 | 31632447 |
Small for dates baby | 39.69 | 12.46 | 37 | 46694 | 3618 | 31646995 |
Bone density decreased | 39.19 | 12.46 | 27 | 46704 | 1708 | 31648905 |
Cerebral toxoplasmosis | 39.11 | 12.46 | 26 | 46705 | 1551 | 31649062 |
Urine calcium increased | 38.98 | 12.46 | 10 | 46721 | 41 | 31650572 |
Nephrolithiasis | 38.80 | 12.46 | 108 | 46623 | 27231 | 31623382 |
Confusional state | 37.97 | 12.46 | 88 | 46643 | 133246 | 31517367 |
Cardiac failure congestive | 37.50 | 12.46 | 37 | 46694 | 79350 | 31571263 |
Aminoaciduria | 37.48 | 12.46 | 12 | 46719 | 122 | 31650491 |
Life expectancy shortened | 37.20 | 12.46 | 10 | 46721 | 51 | 31650562 |
Osteopenia | 36.94 | 12.46 | 39 | 46692 | 4432 | 31646181 |
Mycobacterium avium complex immune restoration disease | 36.77 | 12.46 | 9 | 46722 | 29 | 31650584 |
Tearfulness | 36.64 | 12.46 | 27 | 46704 | 1900 | 31648713 |
Acute hepatitis C | 36.37 | 12.46 | 11 | 46720 | 91 | 31650522 |
Wheezing | 36.27 | 12.46 | 5 | 46726 | 35981 | 31614632 |
Mitochondrial myopathy | 36.20 | 12.46 | 13 | 46718 | 192 | 31650421 |
Cardio-respiratory arrest | 35.31 | 12.46 | 16 | 46715 | 51710 | 31598903 |
Hepatotoxicity | 34.84 | 12.46 | 83 | 46648 | 19043 | 31631570 |
Macrocephaly | 34.60 | 12.46 | 16 | 46715 | 464 | 31650149 |
White matter lesion | 34.52 | 12.46 | 18 | 46713 | 681 | 31649932 |
Intentional product misuse | 34.43 | 12.46 | 7 | 46724 | 37944 | 31612669 |
Liver disorder | 34.23 | 12.46 | 109 | 46622 | 29598 | 31621015 |
Prostate cancer | 33.98 | 12.46 | 7 | 46724 | 37594 | 31613019 |
Ascites | 33.96 | 12.46 | 135 | 46596 | 40878 | 31609735 |
Renal tubular acidosis | 33.94 | 12.46 | 27 | 46704 | 2130 | 31648483 |
Viraemia | 33.78 | 12.46 | 21 | 46710 | 1115 | 31649498 |
Blood phosphorus abnormal | 33.66 | 12.46 | 11 | 46720 | 120 | 31650493 |
Mycobacterial infection | 33.01 | 12.46 | 27 | 46704 | 2216 | 31648397 |
Osteoporotic fracture | 32.82 | 12.46 | 20 | 46711 | 1025 | 31649588 |
Death neonatal | 32.77 | 12.46 | 14 | 46717 | 335 | 31650278 |
Psychomotor skills impaired | 32.70 | 12.46 | 31 | 46700 | 3096 | 31647517 |
Febrile neutropenia | 32.66 | 12.46 | 83 | 46648 | 121766 | 31528847 |
Psoriasis | 32.60 | 12.46 | 14 | 46717 | 46705 | 31603908 |
Disease progression | 32.46 | 12.46 | 52 | 46679 | 90412 | 31560201 |
Blood pyruvic acid increased | 32.45 | 12.46 | 7 | 46724 | 10 | 31650603 |
Dizziness | 31.98 | 12.46 | 168 | 46563 | 198979 | 31451634 |
Hydrocele | 31.58 | 12.46 | 25 | 46706 | 1958 | 31648655 |
Oesophageal atresia | 31.58 | 12.46 | 15 | 46716 | 463 | 31650150 |
Toxicity to various agents | 31.49 | 12.46 | 149 | 46582 | 181338 | 31469275 |
Feeling abnormal | 31.28 | 12.46 | 23 | 46708 | 56979 | 31593634 |
Congenital hydronephrosis | 31.24 | 12.46 | 17 | 46714 | 702 | 31649911 |
Rhabdomyosarcoma | 31.19 | 12.46 | 9 | 46722 | 62 | 31650551 |
Cerebrovascular accident | 31.13 | 12.46 | 43 | 46688 | 79441 | 31571172 |
Cushing's syndrome | 30.90 | 12.46 | 14 | 46717 | 387 | 31650226 |
Flushing | 30.81 | 12.46 | 4 | 46727 | 30124 | 31620489 |
Chronic obstructive pulmonary disease | 30.79 | 12.46 | 14 | 46717 | 45152 | 31605461 |
Thrombosis | 30.77 | 12.46 | 14 | 46717 | 45137 | 31605476 |
Transaminases increased | 30.53 | 12.46 | 92 | 46639 | 24249 | 31626364 |
Therapeutic product effect decreased | 30.48 | 12.46 | 5 | 46726 | 31617 | 31618996 |
Somnolence | 30.47 | 12.46 | 63 | 46668 | 99382 | 31551231 |
Epistaxis | 30.35 | 12.46 | 21 | 46710 | 53686 | 31596927 |
Neurodevelopmental disorder | 30.25 | 12.46 | 14 | 46717 | 407 | 31650206 |
Stevens-Johnson syndrome | 30.15 | 12.46 | 74 | 46657 | 17298 | 31633315 |
HIV lipodystrophy | 29.76 | 12.46 | 7 | 46724 | 18 | 31650595 |
Anaemia | 29.50 | 12.46 | 460 | 46271 | 213062 | 31437551 |
Hepatitis cholestatic | 29.44 | 12.46 | 44 | 46687 | 7102 | 31643511 |
Cardiac arrest | 29.39 | 12.46 | 54 | 46677 | 89008 | 31561605 |
Drug ineffective | 29.05 | 12.46 | 410 | 46321 | 395163 | 31255450 |
HIV viraemia | 28.96 | 12.46 | 8 | 46723 | 46 | 31650567 |
Hypersplenism | 28.70 | 12.46 | 13 | 46718 | 359 | 31650254 |
HIV test positive | 28.67 | 12.46 | 10 | 46721 | 135 | 31650478 |
Lactate pyruvate ratio increased | 28.50 | 12.46 | 6 | 46725 | 7 | 31650606 |
Speech disorder developmental | 28.34 | 12.46 | 24 | 46707 | 2067 | 31648546 |
Injection site pain | 28.25 | 12.46 | 8 | 46723 | 34626 | 31615987 |
Vanishing bile duct syndrome | 27.86 | 12.46 | 15 | 46716 | 606 | 31650007 |
Muscle spasms | 27.73 | 12.46 | 36 | 46695 | 68282 | 31582331 |
Mitochondrial DNA depletion | 27.61 | 12.46 | 5 | 46726 | 0 | 31650613 |
Tremor | 27.35 | 12.46 | 44 | 46687 | 76376 | 31574237 |
Product use issue | 27.32 | 12.46 | 26 | 46705 | 56733 | 31593880 |
HIV associated nephropathy | 27.13 | 12.46 | 12 | 46719 | 313 | 31650300 |
Cardiac disorder | 26.97 | 12.46 | 12 | 46719 | 39202 | 31611411 |
Meningomyelocele | 26.89 | 12.46 | 10 | 46721 | 164 | 31650449 |
Bone metabolism disorder | 26.81 | 12.46 | 11 | 46720 | 237 | 31650376 |
Astrocytoma, low grade | 26.58 | 12.46 | 8 | 46723 | 65 | 31650548 |
Retroviral rebound syndrome | 26.55 | 12.46 | 6 | 46725 | 12 | 31650601 |
Fat tissue increased | 26.28 | 12.46 | 12 | 46719 | 338 | 31650275 |
Stress | 26.26 | 12.46 | 3 | 46728 | 24938 | 31625675 |
Contusion | 26.26 | 12.46 | 8 | 46723 | 33020 | 31617593 |
Low set ears | 26.21 | 12.46 | 13 | 46718 | 442 | 31650171 |
Hepatitis A | 26.18 | 12.46 | 13 | 46718 | 443 | 31650170 |
Tubulointerstitial nephritis | 26.18 | 12.46 | 73 | 46658 | 18423 | 31632190 |
Viral load decreased | 26.16 | 12.46 | 7 | 46724 | 35 | 31650578 |
Syncope | 26.06 | 12.46 | 54 | 46677 | 85128 | 31565485 |
Bone pain | 26.05 | 12.46 | 75 | 46656 | 19276 | 31631337 |
Neurosyphilis | 25.99 | 12.46 | 7 | 46724 | 36 | 31650577 |
Prenatal screening test abnormal | 25.92 | 12.46 | 6 | 46725 | 14 | 31650599 |
Cardiac failure | 25.87 | 12.46 | 55 | 46676 | 85898 | 31564715 |
Hypophosphataemic osteomalacia | 25.84 | 12.46 | 9 | 46722 | 121 | 31650492 |
Lymph node tuberculosis | 25.81 | 12.46 | 13 | 46718 | 457 | 31650156 |
Hypospadias | 25.42 | 12.46 | 27 | 46704 | 3089 | 31647524 |
COVID-19 | 25.37 | 12.46 | 26 | 46705 | 54795 | 31595818 |
Hepatitis B surface antigen positive | 25.06 | 12.46 | 9 | 46722 | 133 | 31650480 |
Beta 2 microglobulin urine increased | 24.93 | 12.46 | 8 | 46723 | 82 | 31650531 |
Product use in unapproved indication | 24.71 | 12.46 | 70 | 46661 | 99101 | 31551512 |
HIV wasting syndrome | 24.67 | 12.46 | 8 | 46723 | 85 | 31650528 |
Blood uric acid increased | 24.52 | 12.46 | 38 | 46693 | 6332 | 31644281 |
Incorrect dose administered | 24.49 | 12.46 | 11 | 46720 | 35741 | 31614872 |
Cellulitis | 24.30 | 12.46 | 21 | 46710 | 47997 | 31602616 |
Urinary tract infection | 24.14 | 12.46 | 48 | 46683 | 76821 | 31573792 |
Limb deformity | 24.13 | 12.46 | 13 | 46718 | 526 | 31650087 |
Granulomatous rosacea | 24.01 | 12.46 | 9 | 46722 | 151 | 31650462 |
Congenital cytomegalovirus infection | 23.51 | 12.46 | 6 | 46725 | 24 | 31650589 |
Histoplasmosis disseminated | 23.47 | 12.46 | 17 | 46714 | 1165 | 31649448 |
Secondary syphilis | 23.46 | 12.46 | 7 | 46724 | 55 | 31650558 |
Blood triglycerides abnormal | 23.26 | 12.46 | 10 | 46721 | 243 | 31650370 |
Pyrexia | 23.26 | 12.46 | 599 | 46132 | 303241 | 31347372 |
Neonatal asphyxia | 23.23 | 12.46 | 11 | 46720 | 337 | 31650276 |
Anogenital warts | 23.15 | 12.46 | 13 | 46718 | 571 | 31650042 |
Spider naevus | 23.12 | 12.46 | 6 | 46725 | 26 | 31650587 |
Haematochezia | 22.62 | 12.46 | 16 | 46715 | 40448 | 31610165 |
Genital herpes | 22.61 | 12.46 | 13 | 46718 | 598 | 31650015 |
Tuberculoid leprosy | 22.53 | 12.46 | 7 | 46724 | 64 | 31650549 |
Atypical mycobacterial infection | 22.43 | 12.46 | 14 | 46717 | 749 | 31649864 |
Chest discomfort | 22.18 | 12.46 | 24 | 46707 | 49345 | 31601268 |
Intracranial pressure increased | 22.14 | 12.46 | 27 | 46704 | 3588 | 31647025 |
Trimethylaminuria | 22.13 | 12.46 | 5 | 46726 | 10 | 31650603 |
Hyperhidrosis | 22.10 | 12.46 | 41 | 46690 | 67352 | 31583261 |
Withdrawal hepatitis | 22.08 | 12.46 | 4 | 46727 | 0 | 31650613 |
Toxoplasmosis | 22.06 | 12.46 | 17 | 46714 | 1280 | 31649333 |
Angioedema | 22.02 | 12.46 | 11 | 46720 | 33607 | 31617006 |
Amoebiasis | 21.97 | 12.46 | 7 | 46724 | 70 | 31650543 |
Hepatic cytolysis | 21.95 | 12.46 | 49 | 46682 | 10774 | 31639839 |
Anal cancer | 21.91 | 12.46 | 11 | 46720 | 384 | 31650229 |
Hepatitis D | 21.79 | 12.46 | 6 | 46725 | 34 | 31650579 |
Influenza | 21.69 | 12.46 | 20 | 46711 | 44305 | 31606308 |
Live birth | 21.68 | 12.46 | 9 | 46722 | 200 | 31650413 |
Unevaluable event | 21.59 | 12.46 | 9 | 46722 | 30566 | 31620047 |
Pruritus | 21.55 | 12.46 | 103 | 46628 | 125064 | 31525549 |
Cardiac murmur | 21.50 | 12.46 | 37 | 46694 | 6725 | 31643888 |
Meningitis tuberculous | 21.42 | 12.46 | 13 | 46718 | 661 | 31649952 |
Blood creatinine increased | 21.41 | 12.46 | 213 | 46518 | 88865 | 31561748 |
Antimitochondrial antibody positive | 21.37 | 12.46 | 6 | 46725 | 37 | 31650576 |
Blood glucose increased | 21.08 | 12.46 | 36 | 46695 | 61047 | 31589566 |
Foetal growth restriction | 20.99 | 12.46 | 27 | 46704 | 3788 | 31646825 |
Umbilical cord abnormality | 20.96 | 12.46 | 6 | 46725 | 40 | 31650573 |
Parotid gland enlargement | 20.92 | 12.46 | 10 | 46721 | 313 | 31650300 |
Oxygen saturation decreased | 20.85 | 12.46 | 25 | 46706 | 49090 | 31601523 |
Night blindness | 20.81 | 12.46 | 9 | 46722 | 222 | 31650391 |
Blood creatine phosphokinase increased | 20.73 | 12.46 | 119 | 46612 | 41855 | 31608758 |
Urticaria | 20.68 | 12.46 | 33 | 46698 | 57484 | 31593129 |
Pre-eclampsia | 20.59 | 12.46 | 6 | 46725 | 43 | 31650570 |
Hypercholesterolaemia | 20.55 | 12.46 | 40 | 46691 | 7990 | 31642623 |
Strongyloidiasis | 20.52 | 12.46 | 22 | 46709 | 2544 | 31648069 |
Urine phosphorus decreased | 20.35 | 12.46 | 6 | 46725 | 45 | 31650568 |
Weight increased | 20.33 | 12.46 | 59 | 46672 | 82888 | 31567725 |
Bradycardia | 20.33 | 12.46 | 45 | 46686 | 69282 | 31581331 |
Visual field defect | 20.30 | 12.46 | 28 | 46703 | 4200 | 31646413 |
Chest pain | 20.27 | 12.46 | 96 | 46635 | 116861 | 31533752 |
Pulmonary embolism | 20.06 | 12.46 | 58 | 46673 | 81588 | 31569025 |
Bacterial pyelonephritis | 20.06 | 12.46 | 9 | 46722 | 243 | 31650370 |
Primary syphilis | 20.00 | 12.46 | 5 | 46726 | 18 | 31650595 |
Asthma | 19.95 | 12.46 | 20 | 46711 | 42591 | 31608022 |
Macrocytosis | 19.82 | 12.46 | 14 | 46717 | 922 | 31649691 |
AIDS related complication | 19.79 | 12.46 | 5 | 46726 | 19 | 31650594 |
Normal newborn | 19.78 | 12.46 | 8 | 46723 | 166 | 31650447 |
Diaphragmatic hernia | 19.69 | 12.46 | 9 | 46722 | 254 | 31650359 |
Oropharyngeal pain | 19.59 | 12.46 | 11 | 46720 | 31472 | 31619141 |
Interstitial lung disease | 19.57 | 12.46 | 38 | 46693 | 61365 | 31589248 |
Agitation | 19.55 | 12.46 | 31 | 46700 | 54138 | 31596475 |
Taeniasis | 19.49 | 12.46 | 6 | 46725 | 53 | 31650560 |
Pancreatitis | 19.39 | 12.46 | 104 | 46627 | 35667 | 31614946 |
Exomphalos | 19.39 | 12.46 | 8 | 46723 | 175 | 31650438 |
Perinatal HIV infection | 19.32 | 12.46 | 4 | 46727 | 4 | 31650609 |
Maternal condition affecting foetus | 19.32 | 12.46 | 4 | 46727 | 4 | 31650609 |
Neuromyopathy | 19.23 | 12.46 | 14 | 46717 | 967 | 31649646 |
Liver transplant rejection | 19.22 | 12.46 | 19 | 46712 | 1997 | 31648616 |
Optic atrophy | 19.12 | 12.46 | 13 | 46718 | 805 | 31649808 |
Pilonidal cyst congenital | 19.03 | 12.46 | 5 | 46726 | 23 | 31650590 |
Lower respiratory tract infection | 18.86 | 12.46 | 9 | 46722 | 28228 | 31622385 |
Drug dependence | 18.82 | 12.46 | 5 | 46726 | 22574 | 31628039 |
Oropharyngeal candidiasis | 18.73 | 12.46 | 12 | 46719 | 672 | 31649941 |
Malaria | 18.66 | 12.46 | 8 | 46723 | 193 | 31650420 |
Developmental hip dysplasia | 18.65 | 12.46 | 9 | 46722 | 288 | 31650325 |
Gastrointestinal haemorrhage | 18.61 | 12.46 | 61 | 46670 | 82488 | 31568125 |
Cataract | 18.51 | 12.46 | 6 | 46725 | 23801 | 31626812 |
Cryoglobulinaemia | 18.44 | 12.46 | 10 | 46721 | 410 | 31650203 |
Borderline leprosy | 18.43 | 12.46 | 4 | 46727 | 6 | 31650607 |
Nervous system disorder | 18.43 | 12.46 | 52 | 46679 | 13211 | 31637402 |
Hepatitis C virus test | 18.40 | 12.46 | 6 | 46725 | 65 | 31650548 |
Bronchitis | 18.32 | 12.46 | 18 | 46713 | 38699 | 31611914 |
Back pain | 18.27 | 12.46 | 91 | 46640 | 109322 | 31541291 |
Rectal haemorrhage | 18.22 | 12.46 | 16 | 46715 | 36288 | 31614325 |
Asymptomatic viral hepatitis | 18.21 | 12.46 | 5 | 46726 | 28 | 31650585 |
International normalised ratio increased | 18.17 | 12.46 | 24 | 46707 | 45199 | 31605414 |
Hepatitis B DNA assay positive | 18.15 | 12.46 | 6 | 46725 | 68 | 31650545 |
Abdominal discomfort | 18.15 | 12.46 | 30 | 46701 | 51537 | 31599076 |
Gynaecomastia | 18.06 | 12.46 | 41 | 46690 | 9113 | 31641500 |
Sickle cell disease | 17.87 | 12.46 | 7 | 46724 | 133 | 31650480 |
Blood pressure decreased | 17.85 | 12.46 | 27 | 46704 | 48064 | 31602549 |
Diverticulitis | 17.85 | 12.46 | 3 | 46728 | 18642 | 31631971 |
Chordee | 17.84 | 12.46 | 6 | 46725 | 72 | 31650541 |
Cerebral ventricle dilatation | 17.84 | 12.46 | 13 | 46718 | 899 | 31649714 |
Neonatal pneumothorax | 17.70 | 12.46 | 4 | 46727 | 8 | 31650605 |
Loss of anatomical alignment after fracture reduction | 17.70 | 12.46 | 4 | 46727 | 8 | 31650605 |
Subchondral insufficiency fracture | 17.70 | 12.46 | 4 | 46727 | 8 | 31650605 |
Crystal urine | 17.69 | 12.46 | 6 | 46725 | 74 | 31650539 |
Delirium | 17.67 | 12.46 | 21 | 46710 | 41400 | 31609213 |
Blood uric acid decreased | 17.59 | 12.46 | 9 | 46722 | 327 | 31650286 |
Hydrops foetalis | 17.55 | 12.46 | 10 | 46721 | 452 | 31650161 |
Hyperphosphatasaemia | 17.51 | 12.46 | 5 | 46726 | 33 | 31650580 |
Meconium ileus | 17.51 | 12.46 | 5 | 46726 | 33 | 31650580 |
Hospitalisation | 17.51 | 12.46 | 29 | 46702 | 49778 | 31600835 |
Infection | 17.48 | 12.46 | 62 | 46669 | 81869 | 31568744 |
White blood cell count increased | 17.47 | 12.46 | 19 | 46712 | 38981 | 31611632 |
Anaphylactic reaction | 17.44 | 12.46 | 11 | 46720 | 29542 | 31621071 |
Renal atrophy | 17.41 | 12.46 | 14 | 46717 | 1121 | 31649492 |
Persistent foetal circulation | 17.37 | 12.46 | 9 | 46722 | 336 | 31650277 |
Bulbar palsy | 17.33 | 12.46 | 8 | 46723 | 231 | 31650382 |
Haematoma | 17.21 | 12.46 | 7 | 46724 | 24132 | 31626481 |
Hepatic enzyme increased | 17.21 | 12.46 | 101 | 46630 | 35807 | 31614806 |
Pneumonia aspiration | 17.20 | 12.46 | 19 | 46712 | 38707 | 31611906 |
Acquired aminoaciduria | 17.09 | 12.46 | 4 | 46727 | 10 | 31650603 |
Erosive duodenitis | 17.04 | 12.46 | 15 | 46716 | 1361 | 31649252 |
ADAMTS13 activity decreased | 16.94 | 12.46 | 6 | 46725 | 85 | 31650528 |
Lymphocytic infiltration | 16.91 | 12.46 | 11 | 46720 | 632 | 31649981 |
Melaena | 16.86 | 12.46 | 14 | 46717 | 32640 | 31617973 |
Fracture malunion | 16.81 | 12.46 | 4 | 46727 | 11 | 31650602 |
Cardiogenic shock | 16.81 | 12.46 | 6 | 46725 | 22402 | 31628211 |
Creutzfeldt-Jakob disease | 16.79 | 12.46 | 5 | 46726 | 39 | 31650574 |
Glucose urine present | 16.60 | 12.46 | 13 | 46718 | 1002 | 31649611 |
Polyneuropathy chronic | 16.57 | 12.46 | 5 | 46726 | 41 | 31650572 |
Gonadal dysgenesis | 16.56 | 12.46 | 3 | 46728 | 0 | 31650613 |
Atypical mycobacterial lymphadenitis | 16.56 | 12.46 | 3 | 46728 | 0 | 31650613 |
Meconium stain | 16.56 | 12.46 | 3 | 46728 | 0 | 31650613 |
Alpha 1 foetoprotein increased | 16.49 | 12.46 | 11 | 46720 | 660 | 31649953 |
Femoral neck fracture | 16.47 | 12.46 | 21 | 46710 | 2919 | 31647694 |
Sepsis | 16.44 | 12.46 | 144 | 46587 | 151785 | 31498828 |
Optic nerve cupping | 16.36 | 12.46 | 5 | 46726 | 43 | 31650570 |
Chronic hepatitis B | 16.36 | 12.46 | 5 | 46726 | 43 | 31650570 |
Liver transplant | 16.35 | 12.46 | 19 | 46712 | 2400 | 31648213 |
Hyperkalaemia | 16.34 | 12.46 | 45 | 46686 | 64306 | 31586307 |
Heart rate increased | 16.33 | 12.46 | 22 | 46709 | 41088 | 31609525 |
Neutrophil count decreased | 16.32 | 12.46 | 27 | 46704 | 46367 | 31604246 |
Endocardial fibroelastosis | 16.32 | 12.46 | 4 | 46727 | 13 | 31650600 |
Encephalitis | 16.30 | 12.46 | 33 | 46698 | 6782 | 31643831 |
Dyspnoea exertional | 16.24 | 12.46 | 20 | 46711 | 38817 | 31611796 |
Acute on chronic liver failure | 16.10 | 12.46 | 6 | 46725 | 99 | 31650514 |
Clostridium difficile infection | 16.06 | 12.46 | 3 | 46728 | 17276 | 31633337 |
Rhinorrhoea | 15.89 | 12.46 | 7 | 46724 | 23005 | 31627608 |
Protrusion tongue | 15.81 | 12.46 | 7 | 46724 | 183 | 31650430 |
Bone marrow oedema | 15.79 | 12.46 | 10 | 46721 | 549 | 31650064 |
Hepatitis B e antigen positive | 15.78 | 12.46 | 5 | 46726 | 49 | 31650564 |
Erythema | 15.75 | 12.46 | 63 | 46668 | 80342 | 31570271 |
Dysmorphism | 15.75 | 12.46 | 21 | 46710 | 3051 | 31647562 |
Coccidioidomycosis | 15.74 | 12.46 | 11 | 46720 | 712 | 31649901 |
Anal cancer stage 0 | 15.67 | 12.46 | 4 | 46727 | 16 | 31650597 |
Dehydration | 15.65 | 12.46 | 107 | 46624 | 119004 | 31531609 |
Colitis ulcerative | 15.64 | 12.46 | 4 | 46727 | 18525 | 31632088 |
Distributive shock | 15.63 | 12.46 | 13 | 46718 | 1092 | 31649521 |
Hepatitis viral | 15.62 | 12.46 | 10 | 46721 | 559 | 31650054 |
C-reactive protein increased | 15.59 | 12.46 | 30 | 46701 | 48620 | 31601993 |
Urinary retention | 15.59 | 12.46 | 16 | 46715 | 33709 | 31616904 |
Transient ischaemic attack | 15.56 | 12.46 | 8 | 46723 | 24048 | 31626565 |
Arthropathy | 15.56 | 12.46 | 8 | 46723 | 24043 | 31626570 |
Musculoskeletal stiffness | 15.54 | 12.46 | 23 | 46708 | 41302 | 31609311 |
Psoriatic arthropathy | 15.48 | 12.46 | 5 | 46726 | 19878 | 31630735 |
Anaemia megaloblastic | 15.47 | 12.46 | 7 | 46724 | 193 | 31650420 |
Optic neuropathy | 15.45 | 12.46 | 16 | 46715 | 1777 | 31648836 |
Ear malformation | 15.38 | 12.46 | 8 | 46723 | 301 | 31650312 |
Micrognathia | 15.33 | 12.46 | 8 | 46723 | 303 | 31650310 |
Malabsorption | 15.31 | 12.46 | 17 | 46714 | 2044 | 31648569 |
Non-Hodgkin's lymphoma | 15.31 | 12.46 | 15 | 46716 | 1560 | 31649053 |
Cytokine release syndrome | 15.24 | 12.46 | 3 | 46728 | 16639 | 31633974 |
Sinusitis | 15.23 | 12.46 | 19 | 46712 | 36677 | 31613936 |
Wrong technique in product usage process | 15.21 | 12.46 | 16 | 46715 | 33327 | 31617286 |
Basal cell carcinoma | 15.20 | 12.46 | 4 | 46727 | 18175 | 31632438 |
Respiratory arrest | 15.18 | 12.46 | 10 | 46721 | 26247 | 31624366 |
Glomerulonephritis proliferative | 15.17 | 12.46 | 7 | 46724 | 202 | 31650411 |
Renal glycosuria | 15.12 | 12.46 | 4 | 46727 | 19 | 31650594 |
Full blood count decreased | 15.10 | 12.46 | 3 | 46728 | 16537 | 31634076 |
Portal fibrosis | 15.09 | 12.46 | 8 | 46723 | 313 | 31650300 |
Anxiety | 15.03 | 12.46 | 76 | 46655 | 90957 | 31559656 |
Blood pressure systolic increased | 14.97 | 12.46 | 5 | 46726 | 19465 | 31631148 |
Amylase increased | 14.95 | 12.46 | 28 | 46703 | 5434 | 31645179 |
Optic disc haemorrhage | 14.95 | 12.46 | 5 | 46726 | 59 | 31650554 |
Full blood count abnormal | 14.85 | 12.46 | 3 | 46728 | 16344 | 31634269 |
Sickle cell anaemia | 14.83 | 12.46 | 7 | 46724 | 213 | 31650400 |
Adrenogenital syndrome | 14.79 | 12.46 | 5 | 46726 | 61 | 31650552 |
Anogenital dysplasia | 14.77 | 12.46 | 6 | 46725 | 126 | 31650487 |
Ultrasound antenatal screen | 14.72 | 12.46 | 6 | 46725 | 127 | 31650486 |
Intentional overdose | 14.64 | 12.46 | 24 | 46707 | 41365 | 31609248 |
Musculoskeletal toxicity | 14.59 | 12.46 | 6 | 46725 | 130 | 31650483 |
Liver tenderness | 14.59 | 12.46 | 6 | 46725 | 130 | 31650483 |
Product quality issue | 14.55 | 12.46 | 3 | 46728 | 16108 | 31634505 |
Osteocalcin increased | 14.49 | 12.46 | 3 | 46728 | 3 | 31650610 |
Tracheal fistula repair | 14.49 | 12.46 | 3 | 46728 | 3 | 31650610 |
Hepatitis B DNA decreased | 14.49 | 12.46 | 3 | 46728 | 3 | 31650610 |
Disseminated tuberculosis | 14.41 | 12.46 | 17 | 46714 | 2182 | 31648431 |
Nasal congestion | 14.39 | 12.46 | 6 | 46725 | 20375 | 31630238 |
Overdose | 14.37 | 12.46 | 70 | 46661 | 84594 | 31566019 |
Congenital tuberculosis | 14.34 | 12.46 | 4 | 46727 | 24 | 31650589 |
Psychotic disorder | 14.32 | 12.46 | 68 | 46663 | 22225 | 31628388 |
Hyperphosphaturia | 14.30 | 12.46 | 5 | 46726 | 68 | 31650545 |
Drug intolerance | 14.27 | 12.46 | 35 | 46696 | 51998 | 31598615 |
Headache | 14.25 | 12.46 | 188 | 46543 | 183464 | 31467149 |
Creatinine renal clearance abnormal | 14.25 | 12.46 | 7 | 46724 | 233 | 31650380 |
Erythema elevatum diutinum | 14.20 | 12.46 | 4 | 46727 | 25 | 31650588 |
Red blood cell schistocytes present | 14.19 | 12.46 | 7 | 46724 | 235 | 31650378 |
Hypoglycaemia | 14.18 | 12.46 | 34 | 46697 | 50912 | 31599701 |
Scleral discolouration | 14.06 | 12.46 | 7 | 46724 | 240 | 31650373 |
Disseminated mycobacterium avium complex infection | 14.04 | 12.46 | 5 | 46726 | 72 | 31650541 |
Late developer | 14.03 | 12.46 | 3 | 46728 | 4 | 31650609 |
Osteodystrophy | 14.03 | 12.46 | 3 | 46728 | 4 | 31650609 |
Retroviral infection | 14.03 | 12.46 | 3 | 46728 | 4 | 31650609 |
Sleep apnoea syndrome | 13.95 | 12.46 | 5 | 46726 | 18620 | 31631993 |
Pancytopenia | 13.94 | 12.46 | 193 | 46538 | 87123 | 31563490 |
Mobility decreased | 13.91 | 12.46 | 12 | 46719 | 27457 | 31623156 |
Myopia | 13.90 | 12.46 | 12 | 46719 | 1061 | 31649552 |
Hepatic steatosis | 13.87 | 12.46 | 54 | 46677 | 16185 | 31634428 |
Neuropsychiatric symptoms | 13.87 | 12.46 | 9 | 46722 | 515 | 31650098 |
Neck deformity | 13.79 | 12.46 | 5 | 46726 | 76 | 31650537 |
Aggression | 13.78 | 12.46 | 21 | 46710 | 37270 | 31613343 |
Portal hypertensive gastropathy | 13.67 | 12.46 | 9 | 46722 | 528 | 31650085 |
Nephropathy | 13.66 | 12.46 | 27 | 46704 | 5452 | 31645161 |
Developmental delay | 13.65 | 12.46 | 18 | 46713 | 2587 | 31648026 |
Fluid retention | 13.61 | 12.46 | 10 | 46721 | 24792 | 31625821 |
Goitre | 13.60 | 12.46 | 14 | 46717 | 1545 | 31649068 |
Memory impairment | 13.59 | 12.46 | 22 | 46709 | 38108 | 31612505 |
Retinoblastoma | 13.57 | 12.46 | 4 | 46727 | 30 | 31650583 |
Diarrhoea | 13.57 | 12.46 | 406 | 46325 | 352003 | 31298610 |
Glucose tolerance impaired | 13.56 | 12.46 | 19 | 46712 | 2893 | 31647720 |
Product prescribing error | 13.52 | 12.46 | 6 | 46725 | 19636 | 31630977 |
Ultrasound antenatal screen abnormal | 13.50 | 12.46 | 5 | 46726 | 81 | 31650532 |
Spermatozoa progressive motility abnormal | 13.45 | 12.46 | 4 | 46727 | 31 | 31650582 |
Lymphangiectasia | 13.45 | 12.46 | 4 | 46727 | 31 | 31650582 |
Gout | 13.41 | 12.46 | 5 | 46726 | 18169 | 31632444 |
Syphilis | 13.30 | 12.46 | 8 | 46723 | 400 | 31650213 |
Vision blurred | 13.30 | 12.46 | 26 | 46705 | 41889 | 31608724 |
Oedema peripheral | 13.30 | 12.46 | 101 | 46630 | 109738 | 31540875 |
Congenital pigmentation disorder | 13.28 | 12.46 | 3 | 46728 | 6 | 31650607 |
Benign hepatic neoplasm | 13.28 | 12.46 | 3 | 46728 | 6 | 31650607 |
Molluscum contagiosum | 13.25 | 12.46 | 7 | 46724 | 272 | 31650341 |
Graft infection | 13.25 | 12.46 | 8 | 46723 | 403 | 31650210 |
Tracheal stenosis | 13.14 | 12.46 | 6 | 46725 | 169 | 31650444 |
Hyponatraemia | 13.12 | 12.46 | 60 | 46671 | 73739 | 31576874 |
Intestinal obstruction | 13.12 | 12.46 | 7 | 46724 | 20603 | 31630010 |
Pain in extremity | 13.07 | 12.46 | 109 | 46622 | 116094 | 31534519 |
Subacute sclerosing panencephalitis | 13.03 | 12.46 | 4 | 46727 | 35 | 31650578 |
Ocular icterus | 13.03 | 12.46 | 18 | 46713 | 2705 | 31647908 |
Congenital hydrocephalus | 13.02 | 12.46 | 5 | 46726 | 90 | 31650523 |
Birth trauma | 12.96 | 12.46 | 3 | 46728 | 7 | 31650606 |
Ergot poisoning | 12.93 | 12.46 | 4 | 46727 | 36 | 31650577 |
Stomatitis | 12.92 | 12.46 | 24 | 46707 | 39414 | 31611199 |
Orthostatic hypotension | 12.88 | 12.46 | 10 | 46721 | 24109 | 31626504 |
Plasmablastic lymphoma | 12.78 | 12.46 | 7 | 46724 | 293 | 31650320 |
Skin candida | 12.73 | 12.46 | 8 | 46723 | 433 | 31650180 |
Tracheo-oesophageal fistula | 12.70 | 12.46 | 8 | 46723 | 435 | 31650178 |
Atrial flutter | 12.69 | 12.46 | 3 | 46728 | 14652 | 31635961 |
Congenital anaemia | 12.68 | 12.46 | 3 | 46728 | 8 | 31650605 |
Congenital hearing disorder | 12.67 | 12.46 | 5 | 46726 | 97 | 31650516 |
Pneumonitis | 12.59 | 12.46 | 16 | 46715 | 30636 | 31619977 |
Toxic optic neuropathy | 12.58 | 12.46 | 10 | 46721 | 788 | 31649825 |
Drug withdrawal syndrome | 12.48 | 12.46 | 6 | 46725 | 18744 | 31631869 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Immune reconstitution inflammatory syndrome | 2328.42 | 12.50 | 721 | 57811 | 12269 | 70857643 |
Viral mutation identified | 2250.84 | 12.50 | 536 | 57996 | 3086 | 70866826 |
Virologic failure | 2187.51 | 12.50 | 530 | 58002 | 3320 | 70866592 |
Drug resistance | 1695.03 | 12.50 | 760 | 57772 | 37430 | 70832482 |
Pathogen resistance | 1688.10 | 12.50 | 568 | 57964 | 12711 | 70857201 |
Exposure during pregnancy | 1098.71 | 12.50 | 758 | 57774 | 86959 | 70782953 |
Lipodystrophy acquired | 1068.16 | 12.50 | 306 | 58226 | 3910 | 70866002 |
Abortion spontaneous | 986.54 | 12.50 | 467 | 58065 | 26012 | 70843900 |
Hepatitis B | 917.18 | 12.50 | 318 | 58214 | 7796 | 70862116 |
Stillbirth | 826.12 | 12.50 | 245 | 58287 | 3560 | 70866352 |
Blood HIV RNA increased | 742.81 | 12.50 | 188 | 58344 | 1438 | 70868474 |
Mitochondrial toxicity | 673.93 | 12.50 | 197 | 58335 | 2713 | 70867199 |
Hepatitis B reactivation | 648.42 | 12.50 | 221 | 58311 | 5134 | 70864778 |
Drug interaction | 588.85 | 12.50 | 1094 | 57438 | 380347 | 70489565 |
Abortion induced | 558.33 | 12.50 | 209 | 58323 | 6416 | 70863496 |
Fanconi syndrome acquired | 493.63 | 12.50 | 150 | 58382 | 2377 | 70867535 |
Acquired gene mutation | 476.88 | 12.50 | 140 | 58392 | 1958 | 70867954 |
Hepatitis B DNA increased | 466.55 | 12.50 | 110 | 58422 | 600 | 70869312 |
Osteomalacia | 421.77 | 12.50 | 117 | 58415 | 1317 | 70868595 |
Foetal exposure during pregnancy | 348.06 | 12.50 | 142 | 58390 | 5503 | 70864409 |
Eyelid ptosis | 312.42 | 12.50 | 157 | 58375 | 9945 | 70859967 |
Depression | 303.76 | 12.50 | 569 | 57963 | 198405 | 70671507 |
Viral load increased | 299.69 | 12.50 | 104 | 58428 | 2552 | 70867360 |
Progressive external ophthalmoplegia | 281.33 | 12.50 | 85 | 58447 | 1319 | 70868593 |
Hepatic failure | 269.78 | 12.50 | 283 | 58249 | 57342 | 70812570 |
Hypophosphataemia | 264.55 | 12.50 | 166 | 58366 | 16160 | 70853752 |
CD4 lymphocytes decreased | 253.92 | 12.50 | 91 | 58441 | 2460 | 70867452 |
Lipoatrophy | 252.50 | 12.50 | 66 | 58466 | 581 | 70869331 |
Fanconi syndrome | 244.75 | 12.50 | 90 | 58442 | 2623 | 70867289 |
Treatment noncompliance | 225.65 | 12.50 | 233 | 58299 | 46341 | 70823571 |
Blood bilirubin increased | 219.77 | 12.50 | 259 | 58273 | 59642 | 70810270 |
Nephropathy toxic | 212.65 | 12.50 | 152 | 58380 | 18362 | 70851550 |
Pregnancy | 212.54 | 12.50 | 168 | 58364 | 23613 | 70846299 |
Rheumatoid arthritis | 206.03 | 12.50 | 8 | 58524 | 291797 | 70578115 |
CSF HIV escape syndrome | 198.15 | 12.50 | 48 | 58484 | 299 | 70869613 |
Live birth | 190.95 | 12.50 | 127 | 58405 | 13652 | 70856260 |
Portal hypertension | 189.36 | 12.50 | 97 | 58435 | 6395 | 70863517 |
HIV infection | 189.36 | 12.50 | 63 | 58469 | 1354 | 70868558 |
Meningitis cryptococcal | 189.17 | 12.50 | 79 | 58453 | 3249 | 70866663 |
Multiple-drug resistance | 180.75 | 12.50 | 98 | 58434 | 7257 | 70862655 |
Hepatotoxicity | 177.84 | 12.50 | 200 | 58332 | 43786 | 70826126 |
Pain | 177.77 | 12.50 | 155 | 58377 | 628661 | 70241251 |
Renal tubular disorder | 174.48 | 12.50 | 90 | 58442 | 6020 | 70863892 |
Caesarean section | 170.62 | 12.50 | 111 | 58421 | 11496 | 70858416 |
Diplopia | 170.23 | 12.50 | 159 | 58373 | 27988 | 70841924 |
Hepatic fibrosis | 169.48 | 12.50 | 89 | 58443 | 6178 | 70863734 |
Alanine aminotransferase increased | 164.76 | 12.50 | 371 | 58161 | 147109 | 70722803 |
Kaposi's sarcoma | 160.49 | 12.50 | 48 | 58484 | 718 | 70869194 |
Hypertriglyceridaemia | 159.19 | 12.50 | 107 | 58425 | 11704 | 70858208 |
Peripheral swelling | 155.80 | 12.50 | 10 | 58522 | 236553 | 70633359 |
Jaundice | 152.10 | 12.50 | 197 | 58335 | 49911 | 70820001 |
Joint swelling | 149.62 | 12.50 | 17 | 58515 | 253194 | 70616718 |
Proteinuria | 147.77 | 12.50 | 150 | 58382 | 29224 | 70840688 |
Pulmonary tuberculosis | 145.57 | 12.50 | 87 | 58445 | 7758 | 70862154 |
Fall | 145.22 | 12.50 | 94 | 58438 | 444002 | 70425910 |
Maternal exposure during pregnancy | 143.40 | 12.50 | 303 | 58229 | 115042 | 70754870 |
Completed suicide | 140.01 | 12.50 | 13 | 58519 | 227122 | 70642790 |
Mitochondrial cytopathy | 138.60 | 12.50 | 37 | 58495 | 356 | 70869556 |
Hypomania | 135.71 | 12.50 | 76 | 58456 | 5996 | 70863916 |
Genotype drug resistance test positive | 135.58 | 12.50 | 47 | 58485 | 1149 | 70868763 |
Maternal drugs affecting foetus | 135.34 | 12.50 | 51 | 58481 | 1593 | 70868319 |
Lymphadenopathy | 134.51 | 12.50 | 183 | 58349 | 48608 | 70821304 |
Foetal death | 133.78 | 12.50 | 76 | 58456 | 6163 | 70863749 |
Retinal toxicity | 133.56 | 12.50 | 48 | 58484 | 1308 | 70868604 |
Glycosuria | 132.61 | 12.50 | 54 | 58478 | 2081 | 70867831 |
Off label use | 132.05 | 12.50 | 259 | 58273 | 742801 | 70127111 |
Hyperbilirubinaemia | 127.91 | 12.50 | 123 | 58409 | 22445 | 70847467 |
Infusion related reaction | 125.30 | 12.50 | 10 | 58522 | 197524 | 70672388 |
Lactic acidosis | 124.97 | 12.50 | 206 | 58326 | 64818 | 70805094 |
Hepatitis C | 124.25 | 12.50 | 95 | 58437 | 12712 | 70857200 |
Renal tubular dysfunction | 123.38 | 12.50 | 39 | 58493 | 708 | 70869204 |
Fatigue | 123.11 | 12.50 | 316 | 58216 | 824003 | 70045909 |
Aspartate aminotransferase increased | 122.79 | 12.50 | 302 | 58230 | 126676 | 70743236 |
Nasopharyngitis | 119.28 | 12.50 | 20 | 58512 | 222186 | 70647726 |
Tuberculosis | 116.00 | 12.50 | 97 | 58435 | 14751 | 70855161 |
HIV-associated neurocognitive disorder | 114.87 | 12.50 | 31 | 58501 | 312 | 70869600 |
Hyperlactacidaemia | 114.76 | 12.50 | 64 | 58468 | 5008 | 70864904 |
Product dose omission issue | 113.62 | 12.50 | 21 | 58511 | 217447 | 70652465 |
Mycobacterium avium complex infection | 113.17 | 12.50 | 60 | 58472 | 4246 | 70865666 |
Jaundice cholestatic | 111.47 | 12.50 | 78 | 58454 | 9106 | 70860806 |
Psychotic disorder | 110.94 | 12.50 | 146 | 58386 | 37555 | 70832357 |
Gene mutation | 109.16 | 12.50 | 48 | 58484 | 2243 | 70867669 |
Hepatomegaly | 106.12 | 12.50 | 99 | 58433 | 17393 | 70852519 |
Dyslipidaemia | 104.23 | 12.50 | 77 | 58455 | 9783 | 70860129 |
Arthropathy | 102.90 | 12.50 | 5 | 58527 | 150052 | 70719860 |
Immune reconstitution inflammatory syndrome associated tuberculosis | 99.46 | 12.50 | 34 | 58498 | 796 | 70869116 |
Hepatic cirrhosis | 98.25 | 12.50 | 124 | 58408 | 30607 | 70839305 |
Anaemia | 96.67 | 12.50 | 616 | 57916 | 402807 | 70467105 |
Premature rupture of membranes | 95.95 | 12.50 | 52 | 58480 | 3846 | 70866066 |
Hypouricaemia | 95.13 | 12.50 | 28 | 58504 | 395 | 70869517 |
Osteonecrosis | 93.76 | 12.50 | 118 | 58414 | 29042 | 70840870 |
Synovitis | 93.02 | 12.50 | 3 | 58529 | 129225 | 70740687 |
Pinealoblastoma | 90.39 | 12.50 | 19 | 58513 | 54 | 70869858 |
Hepatic function abnormal | 89.58 | 12.50 | 183 | 58349 | 67813 | 70802099 |
Dyspnoea | 88.07 | 12.50 | 333 | 58199 | 769727 | 70100185 |
Premature labour | 88.01 | 12.50 | 64 | 58468 | 7936 | 70861976 |
Drug-induced liver injury | 87.30 | 12.50 | 162 | 58370 | 55951 | 70813961 |
Urine phosphorus increased | 86.63 | 12.50 | 19 | 58513 | 70 | 70869842 |
Renal impairment | 86.10 | 12.50 | 288 | 58244 | 143649 | 70726263 |
Constipation | 84.36 | 12.50 | 52 | 58480 | 252386 | 70617526 |
Abdominal discomfort | 83.95 | 12.50 | 36 | 58496 | 214622 | 70655290 |
Stevens-Johnson syndrome | 83.21 | 12.50 | 124 | 58408 | 35783 | 70834129 |
Blood alkaline phosphatase increased | 82.47 | 12.50 | 162 | 58370 | 58359 | 70811553 |
Acquired immunodeficiency syndrome | 81.78 | 12.50 | 23 | 58509 | 273 | 70869639 |
Hepatitis | 81.16 | 12.50 | 147 | 58385 | 49833 | 70820079 |
Pre-eclampsia | 80.86 | 12.50 | 56 | 58476 | 6429 | 70863483 |
Osteoporosis | 79.62 | 12.50 | 144 | 58388 | 48763 | 70821149 |
Sinusitis | 78.96 | 12.50 | 21 | 58511 | 169174 | 70700738 |
Fat tissue increased | 78.57 | 12.50 | 29 | 58503 | 854 | 70869058 |
Gamma-glutamyltransferase increased | 77.18 | 12.50 | 145 | 58387 | 50540 | 70819372 |
Hepatocellular carcinoma | 76.27 | 12.50 | 65 | 58467 | 10143 | 70859769 |
Blood lactic acid increased | 75.13 | 12.50 | 67 | 58465 | 11106 | 70858806 |
Blood phosphorus decreased | 74.72 | 12.50 | 52 | 58480 | 6017 | 70863895 |
Injection site pain | 74.43 | 12.50 | 6 | 58526 | 117613 | 70752299 |
Schizophrenia | 74.25 | 12.50 | 80 | 58452 | 16688 | 70853224 |
Psychiatric decompensation | 73.95 | 12.50 | 40 | 58492 | 2947 | 70866965 |
Blood bilirubin unconjugated increased | 73.63 | 12.50 | 28 | 58504 | 897 | 70869015 |
Ophthalmoplegia | 73.34 | 12.50 | 39 | 58493 | 2776 | 70867136 |
Therapeutic product effect decreased | 72.17 | 12.50 | 15 | 58517 | 143003 | 70726909 |
Cytomegalovirus chorioretinitis | 71.40 | 12.50 | 48 | 58484 | 5250 | 70864662 |
Premature baby | 71.34 | 12.50 | 41 | 58491 | 3398 | 70866514 |
Systemic lupus erythematosus | 71.15 | 12.50 | 3 | 58529 | 101899 | 70768013 |
Hepatosplenomegaly | 70.78 | 12.50 | 49 | 58483 | 5621 | 70864291 |
Drug intolerance | 70.65 | 12.50 | 50 | 58482 | 225637 | 70644275 |
Alopecia | 68.96 | 12.50 | 39 | 58493 | 198451 | 70671461 |
Ergot poisoning | 67.73 | 12.50 | 17 | 58515 | 125 | 70869787 |
Blood pressure increased | 67.00 | 12.50 | 36 | 58496 | 188481 | 70681431 |
Retinoblastoma | 66.70 | 12.50 | 16 | 58516 | 95 | 70869817 |
Varices oesophageal | 65.72 | 12.50 | 46 | 58486 | 5371 | 70864541 |
Progressive multifocal leukoencephalopathy | 65.37 | 12.50 | 80 | 58452 | 19134 | 70850778 |
Drug ineffective | 65.03 | 12.50 | 482 | 58050 | 939270 | 69930642 |
Pneumocystis jirovecii pneumonia | 62.82 | 12.50 | 99 | 58433 | 29983 | 70839929 |
Wound | 62.57 | 12.50 | 5 | 58527 | 98727 | 70771185 |
Cachexia | 61.92 | 12.50 | 57 | 58475 | 9843 | 70860069 |
Loss of personal independence in daily activities | 61.90 | 12.50 | 182 | 58350 | 84728 | 70785184 |
Normal newborn | 61.69 | 12.50 | 47 | 58485 | 6253 | 70863659 |
Contusion | 61.45 | 12.50 | 15 | 58517 | 128021 | 70741891 |
Swelling | 61.37 | 12.50 | 40 | 58492 | 188499 | 70681413 |
Hepatic encephalopathy | 61.00 | 12.50 | 83 | 58449 | 22035 | 70847877 |
Hypotension | 60.12 | 12.50 | 155 | 58377 | 404226 | 70465686 |
Cryptococcosis | 59.57 | 12.50 | 36 | 58496 | 3274 | 70866638 |
Hyperlipidaemia | 59.04 | 12.50 | 85 | 58447 | 23778 | 70846134 |
Splenomegaly | 58.50 | 12.50 | 75 | 58457 | 18795 | 70851117 |
Cholelithiasis | 58.35 | 12.50 | 124 | 58408 | 47216 | 70822696 |
Calculus urinary | 58.32 | 12.50 | 30 | 58502 | 1994 | 70867918 |
Ascites | 58.32 | 12.50 | 154 | 58378 | 67393 | 70802519 |
Lipohypertrophy | 58.00 | 12.50 | 23 | 58509 | 826 | 70869086 |
Blood triglycerides increased | 57.61 | 12.50 | 76 | 58456 | 19588 | 70850324 |
Arthralgia | 56.54 | 12.50 | 219 | 58313 | 503171 | 70366741 |
Drug abuse | 55.51 | 12.50 | 26 | 58506 | 147230 | 70722682 |
Cushing's syndrome | 55.48 | 12.50 | 23 | 58509 | 928 | 70868984 |
Amniotic cavity infection | 55.46 | 12.50 | 22 | 58510 | 791 | 70869121 |
Feeling abnormal | 55.41 | 12.50 | 24 | 58508 | 142295 | 70727617 |
Hepatic cytolysis | 54.41 | 12.50 | 73 | 58459 | 19119 | 70850793 |
Transaminases increased | 54.34 | 12.50 | 120 | 58412 | 46898 | 70823014 |
Hepatitis A | 54.19 | 12.50 | 22 | 58510 | 841 | 70869071 |
Facial wasting | 54.08 | 12.50 | 13 | 58519 | 78 | 70869834 |
Lymph node tuberculosis | 54.01 | 12.50 | 23 | 58509 | 993 | 70868919 |
Renal tubular acidosis | 53.76 | 12.50 | 34 | 58498 | 3352 | 70866560 |
Arthritis | 52.14 | 12.50 | 9 | 58523 | 97971 | 70771941 |
Cerebral toxoplasmosis | 51.90 | 12.50 | 28 | 58504 | 2052 | 70867860 |
Product use issue | 51.06 | 12.50 | 44 | 58488 | 179893 | 70690019 |
Hypophosphataemic osteomalacia | 50.59 | 12.50 | 16 | 58516 | 291 | 70869621 |
Nephrolithiasis | 50.49 | 12.50 | 117 | 58415 | 47206 | 70822706 |
Mitochondrial DNA deletion | 50.31 | 12.50 | 9 | 58523 | 6 | 70869906 |
Oligohydramnios | 50.11 | 12.50 | 32 | 58500 | 3208 | 70866704 |
Hepatitis B surface antigen positive | 49.95 | 12.50 | 14 | 58518 | 164 | 70869748 |
Blood creatinine increased | 49.94 | 12.50 | 242 | 58290 | 142759 | 70727153 |
Weight increased | 48.67 | 12.50 | 78 | 58454 | 242253 | 70627659 |
Premature delivery | 48.53 | 12.50 | 73 | 58459 | 21231 | 70848681 |
Alpha 1 foetoprotein abnormal | 48.31 | 12.50 | 11 | 58521 | 50 | 70869862 |
Psoriasis | 48.28 | 12.50 | 11 | 58521 | 98422 | 70771490 |
Injection site erythema | 48.21 | 12.50 | 3 | 58529 | 72921 | 70796991 |
Urinary tract infection | 48.17 | 12.50 | 82 | 58450 | 248687 | 70621225 |
Oesophageal varices haemorrhage | 47.79 | 12.50 | 33 | 58499 | 3770 | 70866142 |
Renal failure | 47.19 | 12.50 | 292 | 58240 | 188778 | 70681134 |
Ectopic pregnancy | 46.82 | 12.50 | 24 | 58508 | 1584 | 70868328 |
Pyrexia | 46.69 | 12.50 | 731 | 57801 | 606221 | 70263691 |
Malignant neoplasm progression | 46.65 | 12.50 | 21 | 58511 | 121718 | 70748194 |
Aminoaciduria | 45.99 | 12.50 | 14 | 58518 | 223 | 70869689 |
Death | 45.80 | 12.50 | 241 | 58291 | 509820 | 70360092 |
Oesophageal candidiasis | 45.64 | 12.50 | 45 | 58487 | 8462 | 70861450 |
Rickets | 45.62 | 12.50 | 11 | 58521 | 67 | 70869845 |
Pancreatitis | 45.35 | 12.50 | 134 | 58398 | 62534 | 70807378 |
Basedow's disease | 44.82 | 12.50 | 14 | 58518 | 244 | 70869668 |
HIV viraemia | 44.81 | 12.50 | 11 | 58521 | 73 | 70869839 |
Headache | 44.78 | 12.50 | 288 | 58244 | 580117 | 70289795 |
Premature separation of placenta | 44.61 | 12.50 | 21 | 58511 | 1151 | 70868761 |
Meningitis tuberculous | 44.18 | 12.50 | 21 | 58511 | 1176 | 70868736 |
Tuberculoma of central nervous system | 43.92 | 12.50 | 17 | 58515 | 572 | 70869340 |
Impaired healing | 43.87 | 12.50 | 5 | 58527 | 74369 | 70795543 |
Inappropriate schedule of product administration | 43.71 | 12.50 | 17 | 58515 | 107538 | 70762374 |
Placental disorder | 43.55 | 12.50 | 19 | 58513 | 871 | 70869041 |
Pain in extremity | 43.37 | 12.50 | 133 | 58399 | 327949 | 70541963 |
Placental insufficiency | 43.27 | 12.50 | 20 | 58512 | 1051 | 70868861 |
CD4 lymphocytes increased | 43.11 | 12.50 | 14 | 58518 | 278 | 70869634 |
Asthma | 43.00 | 12.50 | 23 | 58509 | 120770 | 70749142 |
Influenza | 42.96 | 12.50 | 20 | 58512 | 113680 | 70756232 |
Pruritus | 42.95 | 12.50 | 144 | 58388 | 345416 | 70524496 |
Nodular regenerative hyperplasia | 42.64 | 12.50 | 21 | 58511 | 1272 | 70868640 |
Granulomatous rosacea | 42.54 | 12.50 | 13 | 58519 | 210 | 70869702 |
Rash maculo-papular | 42.38 | 12.50 | 114 | 58418 | 50431 | 70819481 |
Ocular icterus | 42.31 | 12.50 | 35 | 58497 | 5242 | 70864670 |
Atrial fibrillation | 42.28 | 12.50 | 54 | 58478 | 184294 | 70685618 |
Stomatitis | 42.17 | 12.50 | 27 | 58505 | 128484 | 70741428 |
Psoriatic arthropathy | 41.83 | 12.50 | 3 | 58529 | 64768 | 70805144 |
Umbilical cord abnormality | 41.81 | 12.50 | 12 | 58520 | 154 | 70869758 |
Acquired aminoaciduria | 40.73 | 12.50 | 8 | 58524 | 14 | 70869898 |
Hepatitis cholestatic | 40.35 | 12.50 | 51 | 58481 | 12599 | 70857313 |
Lower respiratory tract infection | 40.29 | 12.50 | 21 | 58511 | 111892 | 70758020 |
Oxygen saturation decreased | 40.24 | 12.50 | 23 | 58509 | 116406 | 70753506 |
Hepatitis B virus test | 40.21 | 12.50 | 7 | 58525 | 3 | 70869909 |
Wheezing | 39.75 | 12.50 | 14 | 58518 | 94156 | 70775756 |
Mycobacterium avium complex immune restoration disease | 39.39 | 12.50 | 8 | 58524 | 18 | 70869894 |
Toxicity to various agents | 39.28 | 12.50 | 172 | 58360 | 382000 | 70487912 |
Malaria | 39.07 | 12.50 | 14 | 58518 | 378 | 70869534 |
Hepatic cancer | 39.06 | 12.50 | 44 | 58488 | 9639 | 70860273 |
Anaemia macrocytic | 38.87 | 12.50 | 33 | 58499 | 5122 | 70864790 |
Drug hypersensitivity | 38.65 | 12.50 | 101 | 58431 | 262358 | 70607554 |
Depression suicidal | 38.53 | 12.50 | 26 | 58506 | 2861 | 70867051 |
Pancytopenia | 38.09 | 12.50 | 234 | 58298 | 150873 | 70719039 |
White matter lesion | 38.03 | 12.50 | 22 | 58510 | 1846 | 70868066 |
Oropharyngeal pain | 37.87 | 12.50 | 16 | 58516 | 96294 | 70773618 |
Optic nerve neoplasm | 37.74 | 12.50 | 8 | 58524 | 24 | 70869888 |
HIV associated nephropathy | 37.61 | 12.50 | 13 | 58519 | 315 | 70869597 |
HIV test positive | 37.48 | 12.50 | 10 | 58522 | 96 | 70869816 |
Urine calcium increased | 37.48 | 12.50 | 10 | 58522 | 96 | 70869816 |
Opportunistic infection | 37.37 | 12.50 | 25 | 58507 | 2711 | 70867201 |
Heart rate decreased | 37.00 | 12.50 | 4 | 58528 | 62011 | 70807901 |
Intentional product misuse | 36.89 | 12.50 | 10 | 58522 | 79585 | 70790327 |
Depressive symptom | 36.69 | 12.50 | 32 | 58500 | 5149 | 70864763 |
Withdrawal hepatitis | 36.60 | 12.50 | 6 | 58526 | 0 | 70869912 |
Mitochondrial DNA depletion | 36.60 | 12.50 | 6 | 58526 | 0 | 70869912 |
Brain stem stroke | 36.42 | 12.50 | 15 | 58517 | 595 | 70869317 |
Malaise | 36.40 | 12.50 | 209 | 58323 | 432723 | 70437189 |
Musculoskeletal stiffness | 36.31 | 12.50 | 41 | 58491 | 147719 | 70722193 |
Psychomotor skills impaired | 35.57 | 12.50 | 29 | 58503 | 4255 | 70865657 |
Tearfulness | 35.54 | 12.50 | 31 | 58501 | 4989 | 70864923 |
Mitochondrial myopathy | 35.18 | 12.50 | 12 | 58520 | 279 | 70869633 |
Nasal congestion | 35.01 | 12.50 | 6 | 58526 | 65666 | 70804246 |
Viraemia | 34.59 | 12.50 | 23 | 58509 | 2469 | 70867443 |
Disseminated tuberculosis | 34.56 | 12.50 | 28 | 58504 | 4072 | 70865840 |
Hepatitis B DNA assay positive | 34.45 | 12.50 | 9 | 58523 | 79 | 70869833 |
Muscle spasms | 34.42 | 12.50 | 46 | 58486 | 154000 | 70715912 |
Dizziness | 34.40 | 12.50 | 233 | 58299 | 463908 | 70406004 |
Acute hepatitis C | 34.18 | 12.50 | 11 | 58521 | 212 | 70869700 |
Oral candidiasis | 33.85 | 12.50 | 68 | 58464 | 24884 | 70845028 |
Back pain | 33.67 | 12.50 | 113 | 58419 | 271039 | 70598873 |
Pericarditis | 33.42 | 12.50 | 14 | 58518 | 84691 | 70785221 |
Blister | 33.14 | 12.50 | 21 | 58511 | 100505 | 70769407 |
Hyperphosphaturia | 32.96 | 12.50 | 9 | 58523 | 95 | 70869817 |
Gynaecomastia | 32.78 | 12.50 | 34 | 58498 | 6789 | 70863123 |
Strongyloidiasis | 32.60 | 12.50 | 26 | 58506 | 3697 | 70866215 |
Bone metabolism disorder | 32.39 | 12.50 | 13 | 58519 | 482 | 70869430 |
Blood pressure fluctuation | 32.33 | 12.50 | 5 | 58527 | 59007 | 70810905 |
Mycobacterial infection | 31.92 | 12.50 | 25 | 58507 | 3463 | 70866449 |
Anaphylactic reaction | 31.89 | 12.50 | 11 | 58521 | 74963 | 70794949 |
Bronchitis | 31.66 | 12.50 | 30 | 58502 | 117213 | 70752699 |
Blood phosphorus abnormal | 31.38 | 12.50 | 11 | 58521 | 278 | 70869634 |
Toxoplasmosis | 31.28 | 12.50 | 22 | 58510 | 2588 | 70867324 |
Pregnancy on contraceptive | 31.20 | 12.50 | 15 | 58517 | 862 | 70869050 |
Infection | 31.11 | 12.50 | 81 | 58451 | 210704 | 70659208 |
Renal glycosuria | 31.08 | 12.50 | 7 | 58525 | 30 | 70869882 |
Bilirubin conjugated increased | 30.80 | 12.50 | 29 | 58503 | 5152 | 70864760 |
Neutropenia neonatal | 30.71 | 12.50 | 7 | 58525 | 32 | 70869880 |
Stress | 30.64 | 12.50 | 9 | 58523 | 67957 | 70801955 |
Retroviral rebound syndrome | 30.37 | 12.50 | 6 | 58526 | 11 | 70869901 |
Vanishing bile duct syndrome | 30.34 | 12.50 | 17 | 58515 | 1342 | 70868570 |
Hypercholesterolaemia | 30.31 | 12.50 | 54 | 58478 | 18063 | 70851849 |
Diabetes mellitus | 29.86 | 12.50 | 128 | 58404 | 71696 | 70798216 |
Helicobacter infection | 29.86 | 12.50 | 5 | 58527 | 55651 | 70814261 |
Benign hydatidiform mole | 29.60 | 12.50 | 8 | 58524 | 81 | 70869831 |
Rhinorrhoea | 29.54 | 12.50 | 9 | 58523 | 66362 | 70803550 |
Night blindness | 29.26 | 12.50 | 12 | 58520 | 471 | 70869441 |
Confusional state | 29.19 | 12.50 | 128 | 58404 | 284270 | 70585642 |
AIDS cholangiopathy | 29.10 | 12.50 | 6 | 58526 | 15 | 70869897 |
HIV lipodystrophy | 29.10 | 12.50 | 6 | 58526 | 15 | 70869897 |
Hyperphosphatasaemia | 29.00 | 12.50 | 8 | 58524 | 88 | 70869824 |
Cerebrovascular accident | 28.95 | 12.50 | 46 | 58486 | 143424 | 70726488 |
Somnolence | 28.75 | 12.50 | 87 | 58445 | 215519 | 70654393 |
Chronic kidney disease | 28.69 | 12.50 | 113 | 58419 | 60944 | 70808968 |
Discomfort | 28.45 | 12.50 | 27 | 58505 | 105409 | 70764503 |
Migraine | 28.40 | 12.50 | 12 | 58520 | 72226 | 70797686 |
Spina bifida | 28.29 | 12.50 | 8 | 58524 | 97 | 70869815 |
Liver disorder | 28.17 | 12.50 | 113 | 58419 | 61455 | 70808457 |
Cardio-respiratory arrest | 28.09 | 12.50 | 25 | 58507 | 100652 | 70769260 |
Liver transplant | 27.53 | 12.50 | 25 | 58507 | 4241 | 70865671 |
Tuberculoid leprosy | 27.37 | 12.50 | 8 | 58524 | 110 | 70869802 |
Secondary syphilis | 27.15 | 12.50 | 7 | 58525 | 58 | 70869854 |
Bone density decreased | 27.11 | 12.50 | 40 | 58492 | 11434 | 70858478 |
Amoebiasis | 27.10 | 12.50 | 8 | 58524 | 114 | 70869798 |
Blood triglycerides abnormal | 27.08 | 12.50 | 11 | 58521 | 421 | 70869491 |
Hepatic steatosis | 27.08 | 12.50 | 75 | 58457 | 33738 | 70836174 |
Congenital anomaly | 26.98 | 12.50 | 10 | 58522 | 298 | 70869614 |
Metabolic acidosis | 26.79 | 12.50 | 127 | 58405 | 74219 | 70795693 |
HIV wasting syndrome | 26.64 | 12.50 | 7 | 58525 | 63 | 70869849 |
Respiratory arrest | 26.50 | 12.50 | 6 | 58526 | 53927 | 70815985 |
Fibromyalgia | 26.36 | 12.50 | 4 | 58528 | 47870 | 70822042 |
Diarrhoea | 26.26 | 12.50 | 472 | 58060 | 782869 | 70087043 |
Encephalitis | 26.03 | 12.50 | 43 | 58489 | 13542 | 70856370 |
Flushing | 25.96 | 12.50 | 18 | 58514 | 82154 | 70787758 |
Beta 2 microglobulin urine increased | 25.80 | 12.50 | 8 | 58524 | 136 | 70869776 |
Anogenital warts | 25.73 | 12.50 | 13 | 58519 | 832 | 70869080 |
Intentional overdose | 25.64 | 12.50 | 26 | 58506 | 98409 | 70771503 |
Erythema | 25.56 | 12.50 | 82 | 58450 | 199481 | 70670431 |
COVID-19 | 25.27 | 12.50 | 30 | 58502 | 105727 | 70764185 |
Atypical mycobacterial lymphadenitis | 25.02 | 12.50 | 5 | 58527 | 10 | 70869902 |
Placental infarction | 25.02 | 12.50 | 8 | 58524 | 151 | 70869761 |
Cardiac failure congestive | 24.98 | 12.50 | 46 | 58486 | 135411 | 70734501 |
Hospitalisation | 24.89 | 12.50 | 19 | 58513 | 82549 | 70787363 |
Herpes simplex | 24.89 | 12.50 | 38 | 58494 | 11194 | 70858718 |
Epistaxis | 24.64 | 12.50 | 29 | 58503 | 102598 | 70767314 |
Glucose urine present | 24.55 | 12.50 | 16 | 58516 | 1661 | 70868251 |
Thrombosis | 24.51 | 12.50 | 16 | 58516 | 75389 | 70794523 |
Genital herpes | 24.42 | 12.50 | 17 | 58515 | 1968 | 70867944 |
Tremor | 24.36 | 12.50 | 58 | 58474 | 155566 | 70714346 |
Lymphocytic infiltration | 24.11 | 12.50 | 15 | 58517 | 1437 | 70868475 |
Nervous system disorder | 23.91 | 12.50 | 58 | 58474 | 24088 | 70845824 |
Liver transplant rejection | 23.85 | 12.50 | 20 | 58512 | 3052 | 70866860 |
Borderline leprosy | 23.84 | 12.50 | 5 | 58527 | 14 | 70869898 |
Dermatitis exfoliative | 23.81 | 12.50 | 36 | 58496 | 10515 | 70859397 |
Rhabdomyosarcoma | 23.78 | 12.50 | 8 | 58524 | 178 | 70869734 |
Urine phosphorus decreased | 23.46 | 12.50 | 6 | 58526 | 48 | 70869864 |
Syncope | 23.45 | 12.50 | 65 | 58467 | 165644 | 70704268 |
Hepatitis fulminant | 23.36 | 12.50 | 28 | 58504 | 6553 | 70863359 |
Chronic disease | 23.32 | 12.50 | 7 | 58525 | 106 | 70869806 |
Central nervous system lesion | 23.30 | 12.50 | 39 | 58493 | 12414 | 70857498 |
Blood uric acid increased | 23.29 | 12.50 | 33 | 58499 | 9096 | 70860816 |
Unevaluable event | 23.27 | 12.50 | 7 | 58525 | 52056 | 70817856 |
Primary syphilis | 23.11 | 12.50 | 5 | 58527 | 17 | 70869895 |
Taeniasis | 22.93 | 12.50 | 6 | 58526 | 53 | 70869859 |
Treatment failure | 22.93 | 12.50 | 200 | 58332 | 143942 | 70725970 |
Molluscum contagiosum | 22.78 | 12.50 | 10 | 58522 | 465 | 70869447 |
Anxiety | 22.70 | 12.50 | 99 | 58433 | 220231 | 70649681 |
Blood bicarbonate decreased | 22.62 | 12.50 | 24 | 58508 | 4917 | 70864995 |
Foetal growth restriction | 22.59 | 12.50 | 16 | 58516 | 1903 | 70868009 |
Parotid gland enlargement | 22.44 | 12.50 | 12 | 58520 | 864 | 70869048 |
Intracranial pressure increased | 22.43 | 12.50 | 29 | 58503 | 7327 | 70862585 |
Blood creatine phosphokinase increased | 22.32 | 12.50 | 105 | 58427 | 61158 | 70808754 |
Tubulointerstitial nephritis | 22.30 | 12.50 | 69 | 58463 | 33007 | 70836905 |
Cholestatic liver injury | 22.27 | 12.50 | 22 | 58510 | 4146 | 70865766 |
Osteoporotic fracture | 22.15 | 12.50 | 21 | 58511 | 3763 | 70866149 |
Gastroschisis | 22.09 | 12.50 | 5 | 58527 | 22 | 70869890 |
Burning sensation | 22.07 | 12.50 | 8 | 58524 | 52862 | 70817050 |
Hepatic enzyme increased | 22.02 | 12.50 | 212 | 58320 | 156778 | 70713134 |
Viral load decreased | 21.91 | 12.50 | 5 | 58527 | 23 | 70869889 |
Hepatitis E | 21.91 | 12.50 | 18 | 58514 | 2670 | 70867242 |
Haematochezia | 21.80 | 12.50 | 17 | 58515 | 73064 | 70796848 |
Hyponatraemia | 21.77 | 12.50 | 64 | 58468 | 160023 | 70709889 |
Hydrops foetalis | 21.69 | 12.50 | 8 | 58524 | 235 | 70869677 |
Chronic hepatitis B | 21.69 | 12.50 | 9 | 58523 | 364 | 70869548 |
Urticaria | 21.58 | 12.50 | 66 | 58466 | 162983 | 70706929 |
Hot flush | 21.57 | 12.50 | 7 | 58525 | 49577 | 70820335 |
Anaemia neonatal | 21.57 | 12.50 | 5 | 58527 | 25 | 70869887 |
Bradycardia | 21.51 | 12.50 | 44 | 58488 | 124571 | 70745341 |
Placenta praevia | 21.50 | 12.50 | 11 | 58521 | 723 | 70869189 |
Erosive duodenitis | 21.46 | 12.50 | 15 | 58517 | 1747 | 70868165 |
Fluid retention | 21.22 | 12.50 | 13 | 58519 | 63372 | 70806540 |
Nephropathy | 21.19 | 12.50 | 31 | 58501 | 8794 | 70861118 |
Anembryonic gestation | 21.19 | 12.50 | 9 | 58523 | 386 | 70869526 |
Bulbar palsy | 21.10 | 12.50 | 8 | 58524 | 254 | 70869658 |
Injury | 21.00 | 12.50 | 14 | 58518 | 65231 | 70804681 |
Breech delivery | 20.94 | 12.50 | 5 | 58527 | 29 | 70869883 |
Cardiac arrest | 20.94 | 12.50 | 65 | 58467 | 159769 | 70710143 |
Chronic obstructive pulmonary disease | 20.80 | 12.50 | 20 | 58512 | 77621 | 70792291 |
Haematoma | 20.77 | 12.50 | 7 | 58525 | 48411 | 70821501 |
Swollen tongue | 20.61 | 12.50 | 3 | 58529 | 37043 | 70832869 |
Ileal ulcer | 20.61 | 12.50 | 12 | 58520 | 1019 | 70868893 |
Non-Hodgkin's lymphoma | 20.59 | 12.50 | 14 | 58518 | 1560 | 70868352 |
Hepatitis D | 20.49 | 12.50 | 6 | 58526 | 83 | 70869829 |
Cough | 20.43 | 12.50 | 171 | 58361 | 325206 | 70544706 |
Gestational diabetes | 20.43 | 12.50 | 25 | 58507 | 5976 | 70863936 |
Memory impairment | 20.35 | 12.50 | 28 | 58504 | 92613 | 70777299 |
Isosporiasis | 20.12 | 12.50 | 7 | 58525 | 173 | 70869739 |
Small for dates baby | 20.08 | 12.50 | 9 | 58523 | 440 | 70869472 |
Cryoglobulinaemia | 20.07 | 12.50 | 11 | 58521 | 832 | 70869080 |
Type III hyperlipidaemia | 20.02 | 12.50 | 4 | 58528 | 8 | 70869904 |
Loss of anatomical alignment after fracture reduction | 20.02 | 12.50 | 4 | 58528 | 8 | 70869904 |
Diverticulitis | 19.80 | 12.50 | 5 | 58527 | 41729 | 70828183 |
Cystitis | 19.77 | 12.50 | 7 | 58525 | 46934 | 70822978 |
Chest pain | 19.66 | 12.50 | 124 | 58408 | 251136 | 70618776 |
Antimitochondrial antibody positive | 19.63 | 12.50 | 6 | 58526 | 97 | 70869815 |
Histoplasmosis disseminated | 19.31 | 12.50 | 15 | 58517 | 2053 | 70867859 |
Incorrect dose administered | 19.30 | 12.50 | 16 | 58516 | 66703 | 70803209 |
Hypoglycaemia | 19.28 | 12.50 | 30 | 58502 | 94334 | 70775578 |
Neck pain | 19.26 | 12.50 | 16 | 58516 | 66641 | 70803271 |
Ballismus | 19.20 | 12.50 | 7 | 58525 | 199 | 70869713 |
Neuromyopathy | 19.09 | 12.50 | 13 | 58519 | 1452 | 70868460 |
Abortion missed | 18.92 | 12.50 | 12 | 58520 | 1189 | 70868723 |
Congenital intestinal malformation | 18.87 | 12.50 | 4 | 58528 | 12 | 70869900 |
Lymphadenitis | 18.85 | 12.50 | 20 | 58512 | 4097 | 70865815 |
Osteoarthritis | 18.84 | 12.50 | 20 | 58512 | 74127 | 70795785 |
Cellulitis | 18.77 | 12.50 | 33 | 58499 | 98895 | 70771017 |
Postpartum haemorrhage | 18.72 | 12.50 | 13 | 58519 | 1498 | 70868414 |
Central nervous system immune reconstitution inflammatory response | 18.65 | 12.50 | 5 | 58527 | 49 | 70869863 |
Fat redistribution | 18.63 | 12.50 | 6 | 58526 | 116 | 70869796 |
Hepatitis viral | 18.58 | 12.50 | 11 | 58521 | 963 | 70868949 |
Hepatitis B surface antibody positive | 18.47 | 12.50 | 7 | 58525 | 222 | 70869690 |
Optic nerve cupping | 18.47 | 12.50 | 5 | 58527 | 51 | 70869861 |
Retroviral infection | 18.40 | 12.50 | 4 | 58528 | 14 | 70869898 |
Lip swelling | 18.40 | 12.50 | 3 | 58529 | 34051 | 70835861 |
Bacterial pyelonephritis | 18.32 | 12.50 | 9 | 58523 | 542 | 70869370 |
Plasma cell myeloma | 18.31 | 12.50 | 20 | 58512 | 73181 | 70796731 |
Oropharyngeal candidiasis | 18.31 | 12.50 | 13 | 58519 | 1552 | 70868360 |
Vertical infection transmission | 18.30 | 12.50 | 3 | 58529 | 0 | 70869912 |
Prenatal screening test abnormal | 18.30 | 12.50 | 3 | 58529 | 0 | 70869912 |
AIDS related complex | 18.30 | 12.50 | 3 | 58529 | 0 | 70869912 |
Alpha 1 foetoprotein increased | 18.26 | 12.50 | 10 | 58522 | 755 | 70869157 |
Portal hypertensive gastropathy | 18.25 | 12.50 | 12 | 58520 | 1264 | 70868648 |
Orthostatic hypotension | 18.19 | 12.50 | 10 | 58522 | 51733 | 70818179 |
Chest discomfort | 18.19 | 12.50 | 48 | 58484 | 124333 | 70745579 |
Erythema elevatum diutinum | 18.18 | 12.50 | 4 | 58528 | 15 | 70869897 |
Ultrasound scan abnormal | 18.18 | 12.50 | 7 | 58525 | 232 | 70869680 |
Pubertal failure | 18.18 | 12.50 | 4 | 58528 | 15 | 70869897 |
Blood lactate dehydrogenase increased | 18.13 | 12.50 | 67 | 58465 | 35060 | 70834852 |
Balance disorder | 18.08 | 12.50 | 29 | 58503 | 90099 | 70779813 |
CD4 lymphocytes | 17.98 | 12.50 | 4 | 58528 | 16 | 70869896 |
AIDS related complication | 17.96 | 12.50 | 5 | 58527 | 57 | 70869855 |
Pneumonia aspiration | 17.94 | 12.50 | 15 | 58517 | 62274 | 70807638 |
Visual field defect | 17.93 | 12.50 | 28 | 58504 | 8410 | 70861502 |
Pneumonia | 17.86 | 12.50 | 366 | 58166 | 595866 | 70274046 |
Brain oedema | 17.83 | 12.50 | 51 | 58481 | 23367 | 70846545 |
Amylase increased | 17.82 | 12.50 | 31 | 58501 | 10177 | 70859735 |
Foetal growth abnormality | 17.78 | 12.50 | 4 | 58528 | 17 | 70869895 |
Clostridium difficile infection | 17.75 | 12.50 | 5 | 58527 | 38811 | 70831101 |
Localised infection | 17.74 | 12.50 | 3 | 58529 | 33155 | 70836757 |
Trisomy 21 | 17.73 | 12.50 | 5 | 58527 | 60 | 70869852 |
Therapeutic product effect incomplete | 17.73 | 12.50 | 46 | 58486 | 119836 | 70750076 |
Red blood cell sedimentation rate increased | 17.63 | 12.50 | 5 | 58527 | 38637 | 70831275 |
Astrocytoma, low grade | 17.61 | 12.50 | 6 | 58526 | 139 | 70869773 |
Post inflammatory pigmentation change | 17.51 | 12.50 | 8 | 58524 | 409 | 70869503 |
Disseminated Bacillus Calmette-Guerin infection | 17.41 | 12.50 | 7 | 58525 | 261 | 70869651 |
Paraparesis | 17.28 | 12.50 | 18 | 58514 | 3611 | 70866301 |
Renal atrophy | 17.23 | 12.50 | 13 | 58519 | 1704 | 70868208 |
Paraesthesia | 17.14 | 12.50 | 62 | 58470 | 145475 | 70724437 |
Anal cancer stage 0 | 17.09 | 12.50 | 4 | 58528 | 21 | 70869891 |
Meningomyelocele | 17.09 | 12.50 | 4 | 58528 | 21 | 70869891 |
Plasmodium falciparum infection | 17.09 | 12.50 | 5 | 58527 | 69 | 70869843 |
Bone pain | 17.00 | 12.50 | 85 | 58447 | 50737 | 70819175 |
Disease progression | 16.99 | 12.50 | 69 | 58463 | 156603 | 70713309 |
Product use in unapproved indication | 16.95 | 12.50 | 101 | 58431 | 207377 | 70662535 |
Albuminuria | 16.79 | 12.50 | 9 | 58523 | 651 | 70869261 |
Illness | 16.73 | 12.50 | 3 | 58529 | 31788 | 70838124 |
Drug dependence | 16.71 | 12.50 | 5 | 58527 | 37316 | 70832596 |
Red blood cells urine | 16.70 | 12.50 | 9 | 58523 | 658 | 70869254 |
Dry skin | 16.69 | 12.50 | 13 | 58519 | 55918 | 70813994 |
Gestational hypertension | 16.69 | 12.50 | 13 | 58519 | 1787 | 70868125 |
ADAMTS13 activity decreased | 16.68 | 12.50 | 6 | 58526 | 164 | 70869748 |
Vomiting | 16.67 | 12.50 | 622 | 57910 | 592489 | 70277423 |
Hypersplenism | 16.65 | 12.50 | 8 | 58524 | 459 | 70869453 |
Benign hepatic neoplasm | 16.58 | 12.50 | 5 | 58527 | 77 | 70869835 |
Neurosyphilis | 16.50 | 12.50 | 4 | 58528 | 25 | 70869887 |
Dehydration | 16.48 | 12.50 | 114 | 58418 | 226028 | 70643884 |
Blood uric acid decreased | 16.48 | 12.50 | 11 | 58521 | 1189 | 70868723 |
Cleft lip and palate | 16.37 | 12.50 | 6 | 58526 | 173 | 70869739 |
Ultrasound antenatal screen abnormal | 16.29 | 12.50 | 5 | 58527 | 82 | 70869830 |
Blood pressure systolic increased | 16.23 | 12.50 | 14 | 58518 | 57245 | 70812667 |
Kwashiorkor | 16.23 | 12.50 | 3 | 58529 | 3 | 70869909 |
Cervix operation | 16.23 | 12.50 | 3 | 58529 | 3 | 70869909 |
Funisitis | 16.23 | 12.50 | 3 | 58529 | 3 | 70869909 |
Hepatitis B DNA decreased | 16.23 | 12.50 | 3 | 58529 | 3 | 70869909 |
Hyperhidrosis | 16.20 | 12.50 | 55 | 58477 | 131531 | 70738381 |
Influenza like illness | 16.18 | 12.50 | 18 | 58514 | 65313 | 70804599 |
Portal vein thrombosis | 16.13 | 12.50 | 21 | 58511 | 5341 | 70864571 |
Product prescribing error | 16.08 | 12.50 | 6 | 58526 | 38946 | 70830966 |
Hydrocephalus | 16.04 | 12.50 | 26 | 58506 | 8059 | 70861853 |
Drug reaction with eosinophilia and systemic symptoms | 15.99 | 12.50 | 92 | 58440 | 57921 | 70811991 |
Breast cancer | 15.95 | 12.50 | 4 | 58528 | 33545 | 70836367 |
Eclampsia | 15.87 | 12.50 | 6 | 58526 | 189 | 70869723 |
Musculoskeletal toxicity | 15.87 | 12.50 | 6 | 58526 | 189 | 70869723 |
Insomnia | 15.77 | 12.50 | 110 | 58422 | 217696 | 70652216 |
Viral hepatitis carrier | 15.75 | 12.50 | 4 | 58528 | 31 | 70869881 |
Spermatozoa progressive motility abnormal | 15.75 | 12.50 | 4 | 58528 | 31 | 70869881 |
Choroiditis | 15.67 | 12.50 | 11 | 58521 | 1290 | 70868622 |
Mobility decreased | 15.63 | 12.50 | 39 | 58493 | 102960 | 70766952 |
Rectal haemorrhage | 15.38 | 12.50 | 19 | 58513 | 65812 | 70804100 |
Acute hepatic failure | 15.32 | 12.50 | 54 | 58478 | 27618 | 70842294 |
Eyelid oedema | 15.29 | 12.50 | 33 | 58499 | 12694 | 70857218 |
International normalised ratio increased | 15.25 | 12.50 | 27 | 58505 | 80699 | 70789213 |
Heart rate irregular | 15.24 | 12.50 | 3 | 58529 | 29740 | 70840172 |
Blood pressure decreased | 15.22 | 12.50 | 33 | 58499 | 91482 | 70778430 |
Limb discomfort | 15.22 | 12.50 | 3 | 58529 | 29702 | 70840210 |
Anogenital dysplasia | 15.18 | 12.50 | 5 | 58527 | 104 | 70869808 |
Cardiac failure | 15.08 | 12.50 | 64 | 58468 | 143477 | 70726435 |
Ovarian failure | 15.04 | 12.50 | 8 | 58524 | 570 | 70869342 |
Acute fatty liver of pregnancy | 15.03 | 12.50 | 4 | 58528 | 38 | 70869874 |
Dyspnoea exertional | 15.02 | 12.50 | 26 | 58506 | 78404 | 70791508 |
Visual impairment | 15.01 | 12.50 | 27 | 58505 | 80223 | 70789689 |
Infected vasculitis | 15.01 | 12.50 | 3 | 58529 | 6 | 70869906 |
Carbon dioxide combining power abnormal | 15.01 | 12.50 | 3 | 58529 | 6 | 70869906 |
Hyperbilirubinaemia neonatal | 15.01 | 12.50 | 3 | 58529 | 6 | 70869906 |
Hydromyelia | 15.01 | 12.50 | 3 | 58529 | 6 | 70869906 |
Glycocholic acid increased | 15.01 | 12.50 | 3 | 58529 | 6 | 70869906 |
Glomerulonephritis proliferative | 14.97 | 12.50 | 7 | 58525 | 378 | 70869534 |
Developmental delay | 14.92 | 12.50 | 10 | 58522 | 1088 | 70868824 |
Hyperphosphataemia | 14.86 | 12.50 | 18 | 58514 | 4258 | 70865654 |
Portal fibrosis | 14.83 | 12.50 | 8 | 58524 | 586 | 70869326 |
Plasmablastic lymphoma | 14.78 | 12.50 | 8 | 58524 | 590 | 70869322 |
Hepatic necrosis | 14.76 | 12.50 | 26 | 58506 | 8620 | 70861292 |
Musculoskeletal pain | 14.67 | 12.50 | 33 | 58499 | 90294 | 70779618 |
Upper respiratory tract infection | 14.54 | 12.50 | 27 | 58505 | 79247 | 70790665 |
Crystal urine | 14.51 | 12.50 | 5 | 58527 | 120 | 70869792 |
Lipase increased | 14.43 | 12.50 | 36 | 58496 | 15210 | 70854702 |
Osteocalcin increased | 14.41 | 12.50 | 3 | 58529 | 8 | 70869904 |
Atypical mycobacterial infection | 14.40 | 12.50 | 11 | 58521 | 1469 | 70868443 |
Renal tubular necrosis | 14.40 | 12.50 | 47 | 58485 | 23124 | 70846788 |
Colitis ulcerative | 14.39 | 12.50 | 5 | 58527 | 33918 | 70835994 |
Myopia | 14.34 | 12.50 | 12 | 58520 | 1825 | 70868087 |
Antiviral drug level below therapeutic | 14.34 | 12.50 | 4 | 58528 | 46 | 70869866 |
Portal vein occlusion | 14.34 | 12.50 | 4 | 58528 | 46 | 70869866 |
CSF protein increased | 14.33 | 12.50 | 10 | 58522 | 1162 | 70868750 |
Acute stress disorder | 14.29 | 12.50 | 7 | 58525 | 419 | 70869493 |
Basal cell carcinoma | 14.23 | 12.50 | 5 | 58527 | 33693 | 70836219 |
Distributive shock | 14.22 | 12.50 | 13 | 58519 | 2224 | 70867688 |
Secondary adrenocortical insufficiency | 14.19 | 12.50 | 14 | 58518 | 2633 | 70867279 |
Antiviral drug level above therapeutic | 14.18 | 12.50 | 4 | 58528 | 48 | 70869864 |
Graft infection | 14.16 | 12.50 | 8 | 58524 | 642 | 70869270 |
Necrotising enterocolitis neonatal | 14.15 | 12.50 | 3 | 58529 | 9 | 70869903 |
Acute lymphocytic leukaemia | 14.08 | 12.50 | 20 | 58512 | 5525 | 70864387 |
Pathological fracture | 14.07 | 12.50 | 27 | 58505 | 9556 | 70860356 |
Carnitine deficiency | 14.03 | 12.50 | 6 | 58526 | 262 | 70869650 |
Blood creatine phosphokinase MB increased | 13.97 | 12.50 | 14 | 58518 | 2683 | 70867229 |
Hypoalbuminaemia | 13.93 | 12.50 | 41 | 58491 | 19081 | 70850831 |
Acute hepatitis B | 13.93 | 12.50 | 7 | 58525 | 443 | 70869469 |
Cholestasis | 13.91 | 12.50 | 77 | 58455 | 47795 | 70822117 |
Wrong technique in product usage process | 13.88 | 12.50 | 22 | 58510 | 68676 | 70801236 |
Dry mouth | 13.82 | 12.50 | 23 | 58509 | 70434 | 70799478 |
Pharyngotonsillitis | 13.81 | 12.50 | 6 | 58526 | 272 | 70869640 |
Multiple fractures | 13.76 | 12.50 | 22 | 58510 | 6743 | 70863169 |
Ear pain | 13.70 | 12.50 | 3 | 58529 | 27596 | 70842316 |
Osteodystrophy | 13.69 | 12.50 | 3 | 58529 | 11 | 70869901 |
Ill-defined disorder | 13.65 | 12.50 | 15 | 58517 | 54726 | 70815186 |
Subacute sclerosing panencephalitis | 13.62 | 12.50 | 4 | 58528 | 56 | 70869856 |
Genital ulceration | 13.61 | 12.50 | 8 | 58524 | 691 | 70869221 |
Cervical dysplasia | 13.58 | 12.50 | 12 | 58520 | 1964 | 70867948 |
Optic neuropathy | 13.57 | 12.50 | 15 | 58517 | 3218 | 70866694 |
Pneumonitis | 13.57 | 12.50 | 15 | 58517 | 54582 | 70815330 |
Acute on chronic liver failure | 13.51 | 12.50 | 6 | 58526 | 287 | 70869625 |
Hypervolaemia | 13.49 | 12.50 | 8 | 58524 | 39698 | 70830214 |
Colour vision tests abnormal | 13.48 | 12.50 | 3 | 58529 | 12 | 70869900 |
Cytomegalovirus oesophagitis | 13.48 | 12.50 | 8 | 58524 | 704 | 70869208 |
Cerebellar syndrome | 13.48 | 12.50 | 19 | 58513 | 5212 | 70864700 |
Pleocytosis | 13.47 | 12.50 | 10 | 58522 | 1279 | 70868633 |
Burkitt's lymphoma | 13.46 | 12.50 | 5 | 58527 | 150 | 70869762 |
Prurigo | 13.45 | 12.50 | 10 | 58522 | 1283 | 70868629 |
Anaphylactic shock | 13.42 | 12.50 | 5 | 58527 | 32485 | 70837427 |
Gastrointestinal haemorrhage | 13.39 | 12.50 | 63 | 58469 | 137345 | 70732567 |
Macrocephaly | 13.36 | 12.50 | 4 | 58528 | 60 | 70869852 |
Emotional distress | 13.35 | 12.50 | 7 | 58525 | 37181 | 70832731 |
Heart rate increased | 13.32 | 12.50 | 44 | 58488 | 106104 | 70763808 |
Colitis | 13.31 | 12.50 | 20 | 58512 | 63794 | 70806118 |
Spermatozoa progressive motility decreased | 13.30 | 12.50 | 4 | 58528 | 61 | 70869851 |
Disseminated intravascular coagulation | 13.29 | 12.50 | 59 | 58473 | 33539 | 70836373 |
Dry eye | 13.28 | 12.50 | 5 | 58527 | 32277 | 70837635 |
Bovine tuberculosis | 13.27 | 12.50 | 5 | 58527 | 156 | 70869756 |
Trimethylaminuria | 13.18 | 12.50 | 5 | 58527 | 159 | 70869753 |
Acute HIV infection | 13.18 | 12.50 | 4 | 58528 | 63 | 70869849 |
Subchondral insufficiency fracture | 13.18 | 12.50 | 4 | 58528 | 63 | 70869849 |
Hyperintensity in brain deep nuclei | 13.07 | 12.50 | 4 | 58528 | 65 | 70869847 |
Melanaemia | 13.07 | 12.50 | 4 | 58528 | 65 | 70869847 |
Spinal cord injury | 13.05 | 12.50 | 9 | 58523 | 1026 | 70868886 |
Cystostomy | 13.01 | 12.50 | 4 | 58528 | 66 | 70869846 |
Abdominal pain upper | 12.94 | 12.50 | 100 | 58432 | 193502 | 70676410 |
Congenital diaphragmatic hernia | 12.94 | 12.50 | 3 | 58529 | 15 | 70869897 |
Hepatitis D RNA positive | 12.94 | 12.50 | 3 | 58529 | 15 | 70869897 |
Agitation | 12.93 | 12.50 | 37 | 58495 | 93338 | 70776574 |
Herpes virus infection | 12.83 | 12.50 | 21 | 58511 | 6563 | 70863349 |
Vaccination failure | 12.78 | 12.50 | 10 | 58522 | 1383 | 70868529 |
Syphilis | 12.76 | 12.50 | 7 | 58525 | 530 | 70869382 |
Interstitial lung disease | 12.72 | 12.50 | 44 | 58488 | 104641 | 70765271 |
Hypertension | 12.70 | 12.50 | 170 | 58362 | 295863 | 70574049 |
Hyperuricaemia | 12.68 | 12.50 | 28 | 58504 | 10938 | 70858974 |
Multiple organ dysfunction syndrome | 12.58 | 12.50 | 141 | 58391 | 108374 | 70761538 |
Neuroleptic malignant syndrome | 12.56 | 12.50 | 3 | 58529 | 26004 | 70843908 |
Bone marrow oedema | 12.52 | 12.50 | 10 | 58522 | 1425 | 70868487 |
Therapeutic response decreased | 12.50 | 12.50 | 18 | 58514 | 58435 | 70811477 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Neutropenia | 37.65 | 36.60 | 22 | 638 | 195 | 88937 |
Source | Code | Description |
---|---|---|
ATC | J05AF05 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIVIRALS FOR SYSTEMIC USE DIRECT ACTING ANTIVIRALS Nucleoside and nucleotide reverse transcriptase inhibitors |
ATC | J05AR01 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIVIRALS FOR SYSTEMIC USE DIRECT ACTING ANTIVIRALS Antivirals for treatment of HIV infections, combinations |
ATC | J05AR02 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIVIRALS FOR SYSTEMIC USE DIRECT ACTING ANTIVIRALS Antivirals for treatment of HIV infections, combinations |
ATC | J05AR04 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIVIRALS FOR SYSTEMIC USE DIRECT ACTING ANTIVIRALS Antivirals for treatment of HIV infections, combinations |
ATC | J05AR05 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIVIRALS FOR SYSTEMIC USE DIRECT ACTING ANTIVIRALS Antivirals for treatment of HIV infections, combinations |
ATC | J05AR07 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIVIRALS FOR SYSTEMIC USE DIRECT ACTING ANTIVIRALS Antivirals for treatment of HIV infections, combinations |
ATC | J05AR11 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIVIRALS FOR SYSTEMIC USE DIRECT ACTING ANTIVIRALS Antivirals for treatment of HIV infections, combinations |
ATC | J05AR12 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIVIRALS FOR SYSTEMIC USE DIRECT ACTING ANTIVIRALS Antivirals for treatment of HIV infections, combinations |
ATC | J05AR13 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIVIRALS FOR SYSTEMIC USE DIRECT ACTING ANTIVIRALS Antivirals for treatment of HIV infections, combinations |
ATC | J05AR16 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIVIRALS FOR SYSTEMIC USE DIRECT ACTING ANTIVIRALS Antivirals for treatment of HIV infections, combinations |
ATC | J05AR24 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIVIRALS FOR SYSTEMIC USE DIRECT ACTING ANTIVIRALS Antivirals for treatment of HIV infections, combinations |
ATC | J05AR25 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIVIRALS FOR SYSTEMIC USE DIRECT ACTING ANTIVIRALS Antivirals for treatment of HIV infections, combinations |
ATC | J05AR27 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIVIRALS FOR SYSTEMIC USE DIRECT ACTING ANTIVIRALS Antivirals for treatment of HIV infections, combinations |
FDA MoA | N0000009947 | Nucleoside Reverse Transcriptase Inhibitors |
FDA EPC | N0000175462 | Human Immunodeficiency Virus Nucleoside Analog Reverse Transcriptase Inhibitor |
FDA EPC | N0000175656 | Hepatitis B Virus Nucleoside Analog Reverse Transcriptase Inhibitor |
CHEBI has role | CHEBI:36044 | antiviral drugs |
CHEBI has role | CHEBI:50266 | Prodrugs |
CHEBI has role | CHEBI:50904 | alergeno |
CHEBI has role | CHEBI:53756 | reverse transcriptase inhibitors |
CHEBI has role | CHEBI:64951 | anti-HBV agents |
MeSH PA | D019380 | Anti-HIV Agents |
MeSH PA | D000890 | Anti-Infective Agents |
MeSH PA | D044966 | Anti-Retroviral Agents |
MeSH PA | D000998 | Antiviral Agents |
MeSH PA | D004791 | Enzyme Inhibitors |
MeSH PA | D019384 | Nucleic Acid Synthesis Inhibitors |
MeSH PA | D018894 | Reverse Transcriptase Inhibitors |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Chronic type B viral hepatitis | indication | 61977001 | |
Human immunodeficiency virus infection | indication | 86406008 | DOID:526 |
Prevention of Hepatitis B Reactivation in Immunocompromised Patients | off-label use | ||
Prevention of HIV Infection after Exposure | off-label use | ||
Toxic amblyopia | contraindication | 965003 | |
Myositis | contraindication | 26889001 | DOID:633 |
Hepatic failure | contraindication | 59927004 | |
Pancreatitis | contraindication | 75694006 | DOID:4989 |
Large liver | contraindication | 80515008 | |
Kidney disease | contraindication | 90708001 | DOID:557 |
Lactic acidosis | contraindication | 91273001 | DOID:3650 |
Disorder of muscle | contraindication | 129565002 | DOID:423 |
Steatosis of liver | contraindication | 197321007 | |
Acute pancreatitis | contraindication | 197456007 | DOID:2913 |
Chronic pancreatitis | contraindication | 235494005 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Anemia | contraindication | 271737000 | DOID:2355 |
Hypertriglyceridemia | contraindication | 302870006 | |
Neutropenic disorder | contraindication | 303011007 | DOID:1227 |
Bone marrow depression | contraindication | 307762000 | |
Breastfeeding (mother) | contraindication | 413712001 | |
Obesity | contraindication | 414916001 | DOID:9970 |
Drug Resistance to Anti-retroviral Therapy | contraindication | ||
HLA-B 5701 Positive Status | contraindication |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 12.95 | acidic |
pKa2 | 4.18 | Basic |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
---|---|---|---|---|---|---|---|---|---|---|
150MG;EQ 300MG BASE | DUTREBIS | MERCK SHARP DOHME | N206510 | Feb. 6, 2015 | DISCN | TABLET | ORAL | 7217713 | Oct. 21, 2022 | TREATMENT OF HIV-1 INFECTION |
150MG;EQ 300MG BASE | DUTREBIS | MERCK SHARP DOHME | N206510 | Feb. 6, 2015 | DISCN | TABLET | ORAL | 7435734 | Oct. 21, 2022 | TREATMENT OF HIV-1 INFECTION |
150MG;EQ 300MG BASE | DUTREBIS | MERCK SHARP DOHME | N206510 | Feb. 6, 2015 | DISCN | TABLET | ORAL | 7754731 | March 11, 2029 | TREATMENT OF HIV-1 INFECTION |
EQ 50MG BASE;300MG | DOVATO | VIIV HLTHCARE | N211994 | April 8, 2019 | RX | TABLET | ORAL | 11234985 | Jan. 24, 2031 | TREATMENT OF HIV INFECTION |
100MG;300MG;300MG | DELSTRIGO | MSD MERCK CO | N210807 | Aug. 30, 2018 | RX | TABLET | ORAL | 8486975 | Oct. 7, 2031 | FOR THE TREATMENT OF HIV-1 INFECTION IN ADULT PATIENTS WITH NO PRIOR ANTIRETROVIRAL TREATMENT HISTORY |
100MG;300MG;300MG | DELSTRIGO | MSD MERCK CO | N210807 | Aug. 30, 2018 | RX | TABLET | ORAL | 8486975 | Oct. 7, 2031 | TREATMENT OF HIV-1 INFECTION IN ADULT PATIENTS AS A REPLACEMENT THERAPY IN VIROLOGICALLY SUPPRESSED ADULTS WITH NO HISTORY OF TREATMENT FAILURE AND NO KNOWN SUBSTITUTIONS ASSOCIATED WITH RESISTANCE TO THE INDIVIDUAL COMPONENTS OF DELSTRIGO |
100MG;300MG;300MG | DELSTRIGO | MSD MERCK CO | N210807 | Aug. 30, 2018 | RX | TABLET | ORAL | 8486975 | Oct. 7, 2031 | TREATMENT OF HIV-1 INFECTION IN PEDIATRIC PATIENTS WEIGHING AT LEAST 35KG WITH NO PRIOR ANTIRETROVIRAL TREATMENT HISTORY OR TO REPLACE THE CURRENT ANTIRETROVIRAL REGIMEN IN THOSE WHO ARE VIROLOGICALLY SUPPRESSED |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Exclusivity date | Description |
---|---|---|---|---|---|---|---|---|---|
EQ 50MG BASE;300MG | DOVATO | VIIV HLTHCARE | N211994 | April 8, 2019 | RX | TABLET | ORAL | April 8, 2022 | NEW COMBINATION |
100MG;300MG;300MG | DELSTRIGO | MSD MERCK CO | N210807 | Aug. 30, 2018 | RX | TABLET | ORAL | Sept. 19, 2022 | EXPANDED INDICATION FOR PTS WHO ARE VIROLOGICALLY SUPPRESSED (HIV-1 RNA LESS THAN 50 COPIES/ML) ON A STABLE ARV REGIMEN WITH NO HX OF TX FAILURE AND NO KNOWN SUBSTITUTIONS ASSOCIATED W RESISTANCE TO DORAVIRINE, LAMIVUDINE OR TENOFOVIR DISOPROXIL FUMARATE |
EQ 50MG BASE;300MG | DOVATO | VIIV HLTHCARE | N211994 | April 8, 2019 | RX | TABLET | ORAL | Aug. 6, 2023 | TO REPLACE THE CURRENT ANTIRETROVIRAL REGIMEN IN THOSE WHO ARE VIROLOGICALLY SUPRESSED (HIV-1 RNA LESS THAN 50 COPIES PER ML) ON A STABLE ANTIRETROVIRAL REGIMEN WITH NO HISTORY OF TREATMENT FAILURE |
100MG;300MG;300MG | DELSTRIGO | MSD MERCK CO | N210807 | Aug. 30, 2018 | RX | TABLET | ORAL | Aug. 30, 2023 | NEW CHEMICAL ENTITY |
100MG;300MG;300MG | DELSTRIGO | MSD MERCK CO | N210807 | Aug. 30, 2018 | RX | TABLET | ORAL | Jan. 27, 2025 | NEW PATIENT POPULATION |
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Deoxycytidine kinase | Kinase | WOMBAT-PK | |||||||
Protein P | Polyprotein | INHIBITOR | CHEMBL | CHEMBL | |||||
Reverse transcriptase/RNaseH | Enzyme | INHIBITOR | EC50 | 7.38 | CHEMBL | CHEMBL | |||
Capsid protein | Unclassified | EC50 | 6.43 | CHEMBL |
ID | Source |
---|---|
4020938 | VUID |
N0000148418 | NUI |
D00353 | KEGG_DRUG |
4020938 | VANDF |
C0209738 | UMLSCUI |
CHEBI:63577 | CHEBI |
3TC | PDB_CHEM_ID |
CHEMBL141 | ChEMBL_ID |
DB00709 | DRUGBANK_ID |
D019259 | MESH_DESCRIPTOR_UI |
60825 | PUBCHEM_CID |
6908 | INN_ID |
2T8Q726O95 | UNII |
68244 | RXNORM |
186277 | MMSL |
4956 | MMSL |
d03858 | MMSL |
005079 | NDDF |
108698001 | SNOMEDCT_US |
386897000 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
DELSTRIGO | HUMAN PRESCRIPTION DRUG LABEL | 3 | 0006-5007 | TABLET, FILM COATED | 300 mg | ORAL | NDA | 32 sections |
DELSTRIGO | HUMAN PRESCRIPTION DRUG LABEL | 3 | 0006-5007 | TABLET, FILM COATED | 300 mg | ORAL | NDA | 32 sections |
EPIVIRHBV | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0173-0662 | TABLET, FILM COATED | 100 mg | ORAL | NDA | 26 sections |
EPIVIRHBV | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0173-0663 | SOLUTION | 5 mg | ORAL | NDA | 26 sections |
LAMIVUDINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6583 | TABLET, FILM COATED | 150 mg | ORAL | ANDA | 27 sections |
Lamivudine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10135-605 | SOLUTION | 10 mg | ORAL | ANDA | 25 sections |
Combivir | HUMAN PRESCRIPTION DRUG LABEL | 2 | 16590-061 | TABLET, FILM COATED | 150 mg | ORAL | NDA | 16 sections |
EPIVIR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-367 | TABLET, FILM COATED | 150 mg | ORAL | NDA | 26 sections |
COMBIVIR | HUMAN PRESCRIPTION DRUG LABEL | 2 | 21695-846 | TABLET, FILM COATED | 150 mg | ORAL | NDA | 26 sections |
Lamivudine and Zidovudine | HUMAN PRESCRIPTION DRUG LABEL | 2 | 21695-996 | TABLET, FILM COATED | 150 mg | ORAL | ANDA | 26 sections |
lamivudine | Human Prescription Drug Label | 1 | 31722-001 | TABLET, FILM COATED | 100 mg | ORAL | ANDA | 25 sections |
LAMIVUDINE and ZIDOVUDINE | Human Prescription Drug Label | 2 | 31722-506 | TABLET, FILM COATED | 150 mg | ORAL | ANDA | 25 sections |
LAMIVUDINE and ZIDOVUDINE | Human Prescription Drug Label | 2 | 31722-506 | TABLET, FILM COATED | 150 mg | ORAL | ANDA | 25 sections |
Lamivudine and Zidovudine | HUMAN PRESCRIPTION DRUG LABEL | 2 | 31722-739 | TABLET, FILM COATED | 150 mg | ORAL | ANDA | 24 sections |
Lamivudine | Human Prescription Drug Label | 1 | 31722-752 | TABLET, FILM COATED | 100 mg | ORAL | ANDA | 28 sections |
Lamivudine | Human Prescription Drug Label | 1 | 31722-753 | TABLET, FILM COATED | 150 mg | ORAL | ANDA | 25 sections |
Lamivudine | Human Prescription Drug Label | 1 | 31722-754 | TABLET, FILM COATED | 300 mg | ORAL | ANDA | 25 sections |
Lamivudine | Human Prescription Drug Label | 1 | 33342-001 | TABLET, FILM COATED | 150 mg | ORAL | ANDA | 26 sections |
Lamivudine | Human Prescription Drug Label | 1 | 33342-002 | TABLET, FILM COATED | 300 mg | ORAL | ANDA | 26 sections |
Lamivudine and Zidovudine | Human Prescription Drug Label | 2 | 33342-003 | TABLET | 150 mg | ORAL | ANDA | 25 sections |
Lamivudine and Zidovudine | Human Prescription Drug Label | 2 | 33342-003 | TABLET | 150 mg | ORAL | ANDA | 25 sections |
Abacavir and Lamivudine | Human Prescription Drug Label | 2 | 35573-402 | TABLET, FILM COATED | 300 mg | ORAL | ANDA | 29 sections |
Abacavir and Lamivudine | Human Prescription Drug Label | 2 | 35573-430 | TABLET, FILM COATED | 300 mg | ORAL | ANDA | 27 sections |
Abacavir and Lamivudine | Human Prescription Drug Label | 2 | 35573-430 | TABLET, FILM COATED | 300 mg | ORAL | ANDA | 27 sections |
Abacavir and Lamivudine | HUMAN PRESCRIPTION DRUG LABEL | 2 | 42291-115 | TABLET, FILM COATED | 300 mg | ORAL | ANDA | 28 sections |
Efavirenz, Lamivudine and Tenofovir Disoproxil Fumarate | Human Prescription Drug Label | 3 | 42385-928 | TABLET, FILM COATED | 300 mg | ORAL | ANDA | 30 sections |
Efavirenz, Lamivudine and Tenofovir Disoproxil Fumarate | Human Prescription Drug Label | 3 | 42385-929 | TABLET, FILM COATED | 300 mg | ORAL | ANDA | 30 sections |
Abacavir and Lamivudine | Human Prescription Drug Label | 2 | 42385-962 | TABLET, FILM COATED | 300 mg | ORAL | ANDA | 28 sections |
LAMIVUDINE and ZIDOVUDINE | HUMAN PRESCRIPTION DRUG LABEL | 2 | 43063-900 | TABLET, FILM COATED | 150 mg | ORAL | ANDA | 25 sections |
LAMIVUDINE and ZIDOVUDINE | HUMAN PRESCRIPTION DRUG LABEL | 2 | 43063-900 | TABLET, FILM COATED | 150 mg | ORAL | ANDA | 25 sections |