Stem definition | Drug id | CAS RN |
---|---|---|
uridine derivatives used as antiviral agents and as antineoplastics | 1539 | 134678-17-4 |
Dose | Unit | Route |
---|---|---|
0.30 | g | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 3 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 70 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 67 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 21.81 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 86 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 1.30 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 4.80 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.94 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 9.10 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Aug. 8, 1996 | EMA | VIIV HLTHCARE | |
Nov. 17, 1995 | FDA | VIIV HLTHCARE | |
Jan. 14, 2020 | PMDA | ViiV Healthcare K.K. |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Exposure during pregnancy | 2114.40 | 15.83 | 1095 | 25269 | 119920 | 50458840 |
Abortion spontaneous | 1276.25 | 15.83 | 557 | 25807 | 41215 | 50537545 |
Virologic failure | 1218.05 | 15.83 | 256 | 26108 | 1308 | 50577452 |
Viral mutation identified | 1201.94 | 15.83 | 255 | 26109 | 1374 | 50577386 |
Drug resistance | 1063.02 | 15.83 | 392 | 25972 | 18597 | 50560163 |
Stillbirth | 1017.12 | 15.83 | 287 | 26077 | 5665 | 50573095 |
Pathogen resistance | 814.23 | 15.83 | 239 | 26125 | 5450 | 50573310 |
Immune reconstitution inflammatory syndrome | 781.83 | 15.83 | 230 | 26134 | 5286 | 50573474 |
Foetal exposure during pregnancy | 745.20 | 15.83 | 337 | 26027 | 27022 | 50551738 |
Abortion induced | 658.71 | 15.83 | 229 | 26135 | 9115 | 50569645 |
Premature baby | 376.36 | 15.83 | 186 | 26178 | 18151 | 50560609 |
Pregnancy | 367.84 | 15.83 | 215 | 26149 | 29362 | 50549398 |
Blood HIV RNA increased | 348.66 | 15.83 | 76 | 26288 | 473 | 50578287 |
Live birth | 294.42 | 15.83 | 152 | 26212 | 16256 | 50562504 |
Maternal exposure during pregnancy | 274.31 | 15.83 | 375 | 25989 | 159403 | 50419357 |
Caesarean section | 266.63 | 15.83 | 140 | 26224 | 15499 | 50563261 |
Fanconi syndrome acquired | 264.34 | 15.83 | 67 | 26297 | 856 | 50577904 |
Foetal death | 245.58 | 15.83 | 108 | 26256 | 8072 | 50570688 |
Lipodystrophy acquired | 235.55 | 15.83 | 66 | 26298 | 1263 | 50577497 |
Hepatitis B reactivation | 231.08 | 15.83 | 72 | 26292 | 2015 | 50576745 |
Hepatotoxicity | 215.95 | 15.83 | 149 | 26215 | 27077 | 50551683 |
Maternal drugs affecting foetus | 181.96 | 15.83 | 76 | 26288 | 5001 | 50573759 |
Blood bilirubin increased | 179.01 | 15.83 | 142 | 26222 | 31896 | 50546864 |
CD4 lymphocytes decreased | 177.26 | 15.83 | 53 | 26311 | 1286 | 50577474 |
Treatment noncompliance | 173.54 | 15.83 | 136 | 26228 | 30014 | 50548746 |
Hypomania | 170.11 | 15.83 | 70 | 26294 | 4435 | 50574325 |
Jaundice cholestatic | 161.59 | 15.83 | 70 | 26294 | 5041 | 50573719 |
Premature rupture of membranes | 158.91 | 15.83 | 67 | 26297 | 4513 | 50574247 |
Premature labour | 154.75 | 15.83 | 88 | 26276 | 11388 | 50567372 |
Schizophrenia | 145.67 | 15.83 | 73 | 26291 | 7324 | 50571436 |
Anaemia | 128.97 | 15.83 | 354 | 26010 | 252102 | 50326658 |
Pre-eclampsia | 128.56 | 15.83 | 69 | 26295 | 7975 | 50570785 |
Drug ineffective | 127.92 | 15.83 | 144 | 26220 | 819189 | 49759571 |
Mitochondrial toxicity | 127.72 | 15.83 | 31 | 26333 | 327 | 50578433 |
Pain | 126.03 | 15.83 | 73 | 26291 | 578830 | 49999930 |
Acquired gene mutation | 123.60 | 15.83 | 36 | 26328 | 795 | 50577965 |
Viral load increased | 119.90 | 15.83 | 38 | 26326 | 1125 | 50577635 |
Hepatitis B | 117.90 | 15.83 | 50 | 26314 | 3416 | 50575344 |
Hepatitis B DNA increased | 116.03 | 15.83 | 25 | 26339 | 146 | 50578614 |
Human immunodeficiency virus transmission | 115.75 | 15.83 | 21 | 26343 | 39 | 50578721 |
Fatigue | 112.90 | 15.83 | 122 | 26242 | 707479 | 49871281 |
Fanconi syndrome | 112.51 | 15.83 | 36 | 26328 | 1100 | 50577660 |
Foetal growth restriction | 106.33 | 15.83 | 57 | 26307 | 6570 | 50572190 |
Trisomy 21 | 106 | 15.83 | 27 | 26337 | 352 | 50578408 |
Lactic acidosis | 101.40 | 15.83 | 105 | 26259 | 33250 | 50545510 |
Fall | 101.34 | 15.83 | 25 | 26339 | 334907 | 50243853 |
Joint swelling | 100.73 | 15.83 | 7 | 26357 | 245279 | 50333481 |
Premature delivery | 99.37 | 15.83 | 89 | 26275 | 23574 | 50555186 |
Hypophosphataemia | 96.23 | 15.83 | 58 | 26306 | 8356 | 50570404 |
Lipoatrophy | 95.97 | 15.83 | 24 | 26340 | 289 | 50578471 |
Nephropathy toxic | 93.52 | 15.83 | 56 | 26308 | 7973 | 50570787 |
Psychotic disorder | 89.54 | 15.83 | 81 | 26283 | 21731 | 50557029 |
Normal newborn | 89.37 | 15.83 | 51 | 26313 | 6640 | 50572120 |
Portal hypertension | 86.58 | 15.83 | 40 | 26324 | 3352 | 50575408 |
Osteomalacia | 86.36 | 15.83 | 26 | 26338 | 646 | 50578114 |
Polydactyly | 86.21 | 15.83 | 22 | 26342 | 289 | 50578471 |
Glycosuria | 85.54 | 15.83 | 29 | 26335 | 1065 | 50577695 |
Proteinuria | 85.11 | 15.83 | 70 | 26294 | 16527 | 50562233 |
Hyperbilirubinaemia | 84.49 | 15.83 | 56 | 26308 | 9514 | 50569246 |
Genotype drug resistance test positive | 82.78 | 15.83 | 21 | 26343 | 269 | 50578491 |
Renal tubular dysfunction | 82.25 | 15.83 | 22 | 26342 | 351 | 50578409 |
Mitochondrial cytopathy | 82.05 | 15.83 | 20 | 26344 | 215 | 50578545 |
Peripheral swelling | 81.37 | 15.83 | 7 | 26357 | 205929 | 50372831 |
Off label use | 80.92 | 15.83 | 77 | 26287 | 474349 | 50104411 |
Ventricular septal defect | 79.91 | 15.83 | 40 | 26324 | 4001 | 50574759 |
Placental disorder | 77.95 | 15.83 | 29 | 26335 | 1401 | 50577359 |
Nasopharyngitis | 77.77 | 15.83 | 6 | 26358 | 192921 | 50385839 |
Rheumatoid arthritis | 77.07 | 15.83 | 8 | 26356 | 202542 | 50376218 |
Congenital umbilical hernia | 76.36 | 15.83 | 20 | 26344 | 293 | 50578467 |
Amniotic cavity infection | 76.14 | 15.83 | 27 | 26337 | 1136 | 50577624 |
Birth mark | 76.00 | 15.83 | 17 | 26347 | 121 | 50578639 |
Hyperlactacidaemia | 75.85 | 15.83 | 33 | 26331 | 2400 | 50576360 |
Ectopic kidney | 75.33 | 15.83 | 15 | 26349 | 55 | 50578705 |
Infusion related reaction | 75.33 | 15.83 | 3 | 26361 | 169554 | 50409206 |
Alpha 1 foetoprotein abnormal | 71.50 | 15.83 | 14 | 26350 | 46 | 50578714 |
Abdominal discomfort | 70.57 | 15.83 | 17 | 26347 | 231624 | 50347136 |
Premature separation of placenta | 69.96 | 15.83 | 28 | 26336 | 1650 | 50577110 |
Product dose omission issue | 68.06 | 15.83 | 8 | 26356 | 183830 | 50394930 |
Blood lactic acid increased | 67.77 | 15.83 | 40 | 26324 | 5545 | 50573215 |
Retinoblastoma | 66.47 | 15.83 | 14 | 26350 | 72 | 50578688 |
Jaundice | 65.97 | 15.83 | 75 | 26289 | 26354 | 50552406 |
Rash maculo-papular | 65.48 | 15.83 | 75 | 26289 | 26566 | 50552194 |
Alopecia | 65.45 | 15.83 | 23 | 26341 | 245024 | 50333736 |
Fat tissue increased | 64.54 | 15.83 | 20 | 26344 | 549 | 50578211 |
CSF HIV escape syndrome | 64.37 | 15.83 | 14 | 26350 | 86 | 50578674 |
Hepatomegaly | 62.74 | 15.83 | 49 | 26315 | 10744 | 50568016 |
Pulmonary tuberculosis | 60.93 | 15.83 | 34 | 26330 | 4239 | 50574521 |
Systemic lupus erythematosus | 60.77 | 15.83 | 3 | 26361 | 140619 | 50438141 |
Alanine aminotransferase increased | 59.70 | 15.83 | 138 | 26226 | 88221 | 50490539 |
Oligohydramnios | 59.03 | 15.83 | 37 | 26327 | 5713 | 50573047 |
Ergot poisoning | 58.68 | 15.83 | 13 | 26351 | 88 | 50578672 |
Congenital anomaly | 58.66 | 15.83 | 24 | 26340 | 1497 | 50577263 |
Small for dates baby | 58.63 | 15.83 | 31 | 26333 | 3474 | 50575286 |
Ectopic pregnancy | 58.01 | 15.83 | 27 | 26337 | 2300 | 50576460 |
Renal tubular disorder | 56.82 | 15.83 | 27 | 26337 | 2410 | 50576350 |
Cholelithiasis | 55.88 | 15.83 | 83 | 26281 | 37890 | 50540870 |
Placental insufficiency | 55.58 | 15.83 | 22 | 26342 | 1259 | 50577501 |
Sinusitis | 54.99 | 15.83 | 11 | 26353 | 170547 | 50408213 |
Stevens-Johnson syndrome | 54.75 | 15.83 | 62 | 26302 | 21690 | 50557070 |
Meningitis cryptococcal | 54.39 | 15.83 | 21 | 26343 | 1124 | 50577636 |
Hepatic failure | 54.01 | 15.83 | 75 | 26289 | 32208 | 50546552 |
Aspartate aminotransferase increased | 53.99 | 15.83 | 123 | 26241 | 77875 | 50500885 |
Completed suicide | 53.42 | 15.83 | 4 | 26360 | 131885 | 50446875 |
Lymphadenopathy | 53.33 | 15.83 | 76 | 26288 | 33423 | 50545337 |
Arthralgia | 53.19 | 15.83 | 92 | 26272 | 438610 | 50140150 |
Hypertriglyceridaemia | 53.04 | 15.83 | 34 | 26330 | 5457 | 50573303 |
Foetal distress syndrome | 52.68 | 15.83 | 21 | 26343 | 1224 | 50577536 |
Umbilical cord abnormality | 51.17 | 15.83 | 17 | 26347 | 586 | 50578174 |
Atrial septal defect | 50.94 | 15.83 | 35 | 26329 | 6306 | 50572454 |
Malaria | 49.10 | 15.83 | 13 | 26351 | 199 | 50578561 |
Constipation | 48.60 | 15.83 | 18 | 26346 | 185690 | 50393070 |
Swelling | 48.47 | 15.83 | 22 | 26342 | 200850 | 50377910 |
Drug intolerance | 48.37 | 15.83 | 27 | 26337 | 219077 | 50359683 |
Hepatitis | 48.09 | 15.83 | 70 | 26294 | 31383 | 50547377 |
Pain in extremity | 47.93 | 15.83 | 43 | 26321 | 272822 | 50305938 |
Drug interaction | 47.59 | 15.83 | 218 | 26146 | 199403 | 50379357 |
Anaemia macrocytic | 46.72 | 15.83 | 24 | 26340 | 2535 | 50576225 |
Tuberculosis | 46.48 | 15.83 | 40 | 26324 | 10043 | 50568717 |
Cleft lip and palate | 46.46 | 15.83 | 14 | 26350 | 349 | 50578411 |
Ultrasound antenatal screen abnormal | 45.49 | 15.83 | 11 | 26353 | 114 | 50578646 |
Dyspnoea | 43.22 | 15.83 | 144 | 26220 | 547464 | 50031296 |
Cushing's syndrome | 42.25 | 15.83 | 15 | 26349 | 633 | 50578127 |
Discomfort | 41.93 | 15.83 | 4 | 26360 | 108376 | 50470384 |
Ultrasound scan abnormal | 41.72 | 15.83 | 12 | 26352 | 253 | 50578507 |
Mitochondrial DNA deletion | 41.59 | 15.83 | 7 | 26357 | 6 | 50578754 |
Low birth weight baby | 41.52 | 15.83 | 30 | 26334 | 5851 | 50572909 |
HIV infection | 40.90 | 15.83 | 12 | 26352 | 272 | 50578488 |
Ocular icterus | 39.85 | 15.83 | 24 | 26340 | 3451 | 50575309 |
Blood bilirubin unconjugated increased | 39.60 | 15.83 | 12 | 26352 | 305 | 50578455 |
Immune reconstitution inflammatory syndrome associated tuberculosis | 39.05 | 15.83 | 12 | 26352 | 320 | 50578440 |
Rickets | 38.17 | 15.83 | 8 | 26356 | 40 | 50578720 |
Drug hypersensitivity | 37.91 | 15.83 | 45 | 26319 | 250965 | 50327795 |
Patent ductus arteriosus | 37.76 | 15.83 | 24 | 26340 | 3796 | 50574964 |
Therapeutic product effect decreased | 37.63 | 15.83 | 12 | 26352 | 136038 | 50442722 |
Neonatal disorder | 36.61 | 15.83 | 13 | 26351 | 549 | 50578211 |
Cleft palate | 36.47 | 15.83 | 15 | 26349 | 948 | 50577812 |
Gene mutation | 35.62 | 15.83 | 16 | 26348 | 1255 | 50577505 |
Headache | 35.44 | 15.83 | 140 | 26224 | 506395 | 50072365 |
Gestational diabetes | 35.19 | 15.83 | 30 | 26334 | 7435 | 50571325 |
Pregnancy on contraceptive | 35.19 | 15.83 | 15 | 26349 | 1037 | 50577723 |
Tuberculoma of central nervous system | 34.82 | 15.83 | 11 | 26353 | 322 | 50578438 |
Death neonatal | 34.28 | 15.83 | 10 | 26354 | 222 | 50578538 |
CD4 lymphocytes increased | 33.92 | 15.83 | 9 | 26355 | 139 | 50578621 |
Hypouricaemia | 33.92 | 15.83 | 9 | 26355 | 139 | 50578621 |
Isosporiasis | 32.92 | 15.83 | 7 | 26357 | 38 | 50578722 |
Hepatic enzyme increased | 32.68 | 15.83 | 150 | 26214 | 137230 | 50441530 |
Contusion | 32.65 | 15.83 | 9 | 26355 | 112174 | 50466586 |
Hepatitis A | 32.42 | 15.83 | 11 | 26353 | 405 | 50578355 |
Metabolic acidosis | 32.32 | 15.83 | 66 | 26298 | 38759 | 50540001 |
Placental infarction | 32.25 | 15.83 | 10 | 26354 | 275 | 50578485 |
Benign hydatidiform mole | 32.01 | 15.83 | 8 | 26356 | 96 | 50578664 |
Atrial fibrillation | 31.88 | 15.83 | 7 | 26357 | 101738 | 50477022 |
AIDS cholangiopathy | 31.85 | 15.83 | 6 | 26358 | 15 | 50578745 |
Neural tube defect | 31.60 | 15.83 | 9 | 26355 | 183 | 50578577 |
Cardiac malposition | 30.91 | 15.83 | 7 | 26357 | 53 | 50578707 |
Multiple-drug resistance | 30.73 | 15.83 | 20 | 26344 | 3294 | 50575466 |
Weight increased | 30.67 | 15.83 | 36 | 26328 | 201855 | 50376905 |
Infection | 30.64 | 15.83 | 27 | 26337 | 172927 | 50405833 |
Back pain | 30.56 | 15.83 | 42 | 26322 | 219988 | 50358772 |
Influenza | 30.51 | 15.83 | 5 | 26359 | 89533 | 50489227 |
Hydrops foetalis | 30.37 | 15.83 | 10 | 26354 | 335 | 50578425 |
HIV-associated neurocognitive disorder | 30.18 | 15.83 | 8 | 26356 | 123 | 50578637 |
Pericarditis | 30.18 | 15.83 | 3 | 26361 | 78686 | 50500074 |
Renal tubular acidosis | 29.79 | 15.83 | 15 | 26349 | 1519 | 50577241 |
Neutropenia | 29.77 | 15.83 | 154 | 26210 | 147811 | 50430949 |
Lymphadenitis | 29.55 | 15.83 | 18 | 26346 | 2642 | 50576118 |
Hepatosplenomegaly | 29.21 | 15.83 | 17 | 26347 | 2295 | 50576465 |
Hepatic cytolysis | 29.21 | 15.83 | 28 | 26336 | 8075 | 50570685 |
Neutropenia neonatal | 28.57 | 15.83 | 7 | 26357 | 77 | 50578683 |
Bilirubin conjugated increased | 28.41 | 15.83 | 17 | 26347 | 2415 | 50576345 |
Feeling abnormal | 28.34 | 15.83 | 15 | 26349 | 125477 | 50453283 |
Chronic disease | 28.33 | 15.83 | 7 | 26357 | 80 | 50578680 |
Infertility | 28.25 | 15.83 | 11 | 26353 | 602 | 50578158 |
Ballismus | 28.25 | 15.83 | 7 | 26357 | 81 | 50578679 |
Drug reaction with eosinophilia and systemic symptoms | 28.15 | 15.83 | 52 | 26312 | 28372 | 50550388 |
Dyslipidaemia | 28.10 | 15.83 | 24 | 26340 | 5964 | 50572796 |
Twin pregnancy | 28.01 | 15.83 | 13 | 26351 | 1100 | 50577660 |
Postpartum haemorrhage | 27.89 | 15.83 | 15 | 26349 | 1739 | 50577021 |
Gamma-glutamyltransferase increased | 27.85 | 15.83 | 53 | 26311 | 29570 | 50549190 |
Prenatal screening test abnormal | 27.66 | 15.83 | 5 | 26359 | 9 | 50578751 |
Gestational hypertension | 27.51 | 15.83 | 16 | 26348 | 2157 | 50576603 |
Double outlet right ventricle | 27.03 | 15.83 | 6 | 26358 | 41 | 50578719 |
Cerebral toxoplasmosis | 26.86 | 15.83 | 11 | 26353 | 688 | 50578072 |
Ascites | 26.42 | 15.83 | 58 | 26306 | 35803 | 50542957 |
Pruritus | 26.32 | 15.83 | 69 | 26295 | 283499 | 50295261 |
Bicuspid pulmonary valve | 26.24 | 15.83 | 4 | 26360 | 0 | 50578760 |
Anembryonic gestation | 26.10 | 15.83 | 10 | 26354 | 524 | 50578236 |
Lymph node tuberculosis | 26.02 | 15.83 | 11 | 26353 | 745 | 50578015 |
Hepatitis B surface antigen positive | 25.99 | 15.83 | 6 | 26358 | 50 | 50578710 |
Diarrhoea | 25.93 | 15.83 | 190 | 26174 | 588286 | 49990474 |
Cholestatic liver injury | 25.90 | 15.83 | 15 | 26349 | 2006 | 50576754 |
Product use issue | 25.68 | 15.83 | 24 | 26340 | 149451 | 50429309 |
Funisitis | 25.64 | 15.83 | 5 | 26359 | 16 | 50578744 |
Vomiting | 25.41 | 15.83 | 358 | 26006 | 460400 | 50118360 |
Malignant neoplasm progression | 25.10 | 15.83 | 3 | 26361 | 68121 | 50510639 |
Ovarian failure | 24.96 | 15.83 | 12 | 26352 | 1099 | 50577661 |
Hyperphosphaturia | 24.57 | 15.83 | 5 | 26359 | 21 | 50578739 |
Blood pressure increased | 24.53 | 15.83 | 20 | 26344 | 133112 | 50445648 |
Urinary tract infection | 24.41 | 15.83 | 50 | 26314 | 223970 | 50354790 |
Neonatal aspiration | 24.36 | 15.83 | 7 | 26357 | 147 | 50578613 |
Cytomegalovirus chorioretinitis | 24.28 | 15.83 | 13 | 26351 | 1494 | 50577266 |
Muscle spasms | 24.23 | 15.83 | 18 | 26346 | 125535 | 50453225 |
Retinal toxicity | 24.20 | 15.83 | 12 | 26352 | 1176 | 50577584 |
Acquired aminoaciduria | 24.01 | 15.83 | 4 | 26360 | 3 | 50578757 |
Fat redistribution | 24.01 | 15.83 | 4 | 26360 | 3 | 50578757 |
Eyelid oedema | 23.85 | 15.83 | 27 | 26337 | 9439 | 50569321 |
Kaposi's sarcoma | 23.76 | 15.83 | 7 | 26357 | 161 | 50578599 |
Abortion missed | 23.64 | 15.83 | 13 | 26351 | 1575 | 50577185 |
Alpha 1 foetoprotein increased | 23.64 | 15.83 | 7 | 26357 | 164 | 50578596 |
Hypophosphataemic osteomalacia | 23.64 | 15.83 | 7 | 26357 | 164 | 50578596 |
Hepatic displacement | 23.54 | 15.83 | 5 | 26359 | 27 | 50578733 |
Fallot's tetralogy | 23.50 | 15.83 | 6 | 26358 | 79 | 50578681 |
Foetal anaemia | 23.09 | 15.83 | 5 | 26359 | 30 | 50578730 |
Cachexia | 22.98 | 15.83 | 19 | 26345 | 4514 | 50574246 |
Isoimmune haemolytic disease | 22.95 | 15.83 | 5 | 26359 | 31 | 50578729 |
Hepatitis B DNA assay positive | 22.95 | 15.83 | 5 | 26359 | 31 | 50578729 |
Anaemia neonatal | 22.87 | 15.83 | 8 | 26356 | 323 | 50578437 |
Musculoskeletal stiffness | 22.82 | 15.83 | 20 | 26344 | 128461 | 50450299 |
Asthma | 22.78 | 15.83 | 9 | 26355 | 89328 | 50489432 |
Haemorrhage in pregnancy | 22.75 | 15.83 | 13 | 26351 | 1696 | 50577064 |
Lipase increased | 22.61 | 15.83 | 25 | 26339 | 8516 | 50570244 |
Anxiety | 22.61 | 15.83 | 36 | 26328 | 177570 | 50401190 |
Cardiac murmur | 22.60 | 15.83 | 28 | 26336 | 10756 | 50568004 |
AIDS related complication | 22.20 | 15.83 | 4 | 26360 | 7 | 50578753 |
Diastasis recti abdominis | 22.18 | 15.83 | 5 | 26359 | 37 | 50578723 |
Pleocytosis | 22.16 | 15.83 | 9 | 26355 | 551 | 50578209 |
Renal failure | 22.14 | 15.83 | 112 | 26252 | 106521 | 50472239 |
Dyschezia | 22.09 | 15.83 | 13 | 26351 | 1791 | 50576969 |
Migraine | 21.98 | 15.83 | 6 | 26358 | 75274 | 50503486 |
Type III hyperlipidaemia | 21.85 | 15.83 | 4 | 26360 | 8 | 50578752 |
Cholestasis of pregnancy | 21.79 | 15.83 | 11 | 26353 | 1120 | 50577640 |
Blood creatine phosphokinase MB increased | 21.69 | 15.83 | 11 | 26353 | 1131 | 50577629 |
Breech delivery | 21.62 | 15.83 | 5 | 26359 | 42 | 50578718 |
Dizziness | 21.55 | 15.83 | 100 | 26264 | 346269 | 50232491 |
Lipohypertrophy | 21.37 | 15.83 | 9 | 26355 | 604 | 50578156 |
Antiviral drug level below therapeutic | 21.31 | 15.83 | 5 | 26359 | 45 | 50578715 |
Myopathy toxic | 21.22 | 15.83 | 8 | 26356 | 401 | 50578359 |
Blister | 21.14 | 15.83 | 9 | 26355 | 85409 | 50493351 |
Psoriasis | 21.10 | 15.83 | 5 | 26359 | 68995 | 50509765 |
Respiratory distress | 20.99 | 15.83 | 48 | 26316 | 30441 | 50548319 |
Blood creatine phosphokinase increased | 20.98 | 15.83 | 44 | 26320 | 26323 | 50552437 |
Aminoaciduria | 20.97 | 15.83 | 6 | 26358 | 124 | 50578636 |
Intentional product use issue | 20.88 | 15.83 | 7 | 26357 | 76911 | 50501849 |
Bovine tuberculosis | 20.66 | 15.83 | 5 | 26359 | 52 | 50578708 |
Placenta praevia | 20.60 | 15.83 | 10 | 26354 | 936 | 50577824 |
Lower respiratory tract infection | 20.60 | 15.83 | 12 | 26352 | 95189 | 50483571 |
Pubertal failure | 20.46 | 15.83 | 4 | 26360 | 13 | 50578747 |
Developmental delay | 20.39 | 15.83 | 11 | 26353 | 1283 | 50577477 |
Spinal cord injury | 20.27 | 15.83 | 9 | 26355 | 687 | 50578073 |
Breast neoplasm | 20.24 | 15.83 | 11 | 26353 | 1302 | 50577458 |
Hydrocephalus | 20.07 | 15.83 | 18 | 26346 | 4770 | 50573990 |
Influenza like illness | 20.05 | 15.83 | 3 | 26361 | 57456 | 50521304 |
CSF protein increased | 19.99 | 15.83 | 8 | 26356 | 471 | 50578289 |
Wheezing | 19.98 | 15.83 | 4 | 26360 | 62043 | 50516717 |
Pallor | 19.97 | 15.83 | 40 | 26324 | 23159 | 50555601 |
Ventricular hypoplasia | 19.97 | 15.83 | 6 | 26358 | 148 | 50578612 |
Pyrexia | 19.96 | 15.83 | 293 | 26071 | 379910 | 50198850 |
Osteoporosis | 19.95 | 15.83 | 60 | 26304 | 44819 | 50533941 |
Hypotension | 19.84 | 15.83 | 60 | 26304 | 235409 | 50343351 |
Carnitine deficiency | 19.74 | 15.83 | 6 | 26358 | 154 | 50578606 |
Vertical infection transmission | 19.68 | 15.83 | 3 | 26361 | 0 | 50578760 |
Loss of personal independence in daily activities | 19.68 | 15.83 | 6 | 26358 | 70044 | 50508716 |
Portal vein thrombosis | 19.66 | 15.83 | 13 | 26351 | 2199 | 50576561 |
Malaise | 19.63 | 15.83 | 99 | 26265 | 335433 | 50243327 |
Death | 19.61 | 15.83 | 95 | 26269 | 325284 | 50253476 |
Pharyngotonsillitis | 19.60 | 15.83 | 6 | 26358 | 158 | 50578602 |
Disseminated Bacillus Calmette-Guerin infection | 19.43 | 15.83 | 4 | 26360 | 18 | 50578742 |
Renal glycosuria | 19.43 | 15.83 | 4 | 26360 | 18 | 50578742 |
Ebstein's anomaly | 19.43 | 15.83 | 4 | 26360 | 18 | 50578742 |
Necrotising colitis | 19.43 | 15.83 | 8 | 26356 | 507 | 50578253 |
Transaminases increased | 19.37 | 15.83 | 44 | 26320 | 27780 | 50550980 |
Amenorrhoea | 19.36 | 15.83 | 23 | 26341 | 8461 | 50570299 |
Varices oesophageal | 19.17 | 15.83 | 14 | 26350 | 2775 | 50575985 |
Social avoidant behaviour | 19.14 | 15.83 | 14 | 26350 | 2783 | 50575977 |
Meningitis tuberculous | 19.08 | 15.83 | 8 | 26356 | 531 | 50578229 |
Insomnia | 19.06 | 15.83 | 39 | 26325 | 174826 | 50403934 |
Eclampsia | 19.02 | 15.83 | 7 | 26357 | 328 | 50578432 |
Pulmonary artery atresia | 18.77 | 15.83 | 4 | 26360 | 22 | 50578738 |
Thyroid tuberculosis | 18.77 | 15.83 | 4 | 26360 | 22 | 50578738 |
Toxicity to various agents | 18.73 | 15.83 | 53 | 26311 | 212446 | 50366314 |
Acquired immunodeficiency syndrome | 18.62 | 15.83 | 5 | 26359 | 81 | 50578679 |
Diaphragmatic aplasia | 18.62 | 15.83 | 4 | 26360 | 23 | 50578737 |
Hemiataxia | 18.47 | 15.83 | 4 | 26360 | 24 | 50578736 |
Aqueductal stenosis | 18.47 | 15.83 | 4 | 26360 | 24 | 50578736 |
Placental necrosis | 18.20 | 15.83 | 4 | 26360 | 26 | 50578734 |
Cryptococcosis | 18.18 | 15.83 | 9 | 26355 | 879 | 50577881 |
Lactate pyruvate ratio increased | 18.08 | 15.83 | 5 | 26359 | 91 | 50578669 |
Mycobacterium avium complex infection | 18.08 | 15.83 | 13 | 26351 | 2517 | 50576243 |
Myelopathy | 17.93 | 15.83 | 13 | 26351 | 2548 | 50576212 |
Acute stress disorder | 17.89 | 15.83 | 6 | 26358 | 213 | 50578547 |
HELLP syndrome | 17.88 | 15.83 | 9 | 26355 | 910 | 50577850 |
Therapeutic product effect incomplete | 17.81 | 15.83 | 13 | 26351 | 91502 | 50487258 |
Hepatitis C | 17.74 | 15.83 | 17 | 26347 | 4900 | 50573860 |
Delayed puberty | 17.73 | 15.83 | 5 | 26359 | 98 | 50578662 |
Oxygen saturation decreased | 17.68 | 15.83 | 8 | 26356 | 73240 | 50505520 |
Secondary hypogonadism | 17.63 | 15.83 | 5 | 26359 | 100 | 50578660 |
Cervix operation | 17.60 | 15.83 | 3 | 26361 | 3 | 50578757 |
Delivery | 17.58 | 15.83 | 8 | 26356 | 647 | 50578113 |
Bronchitis | 17.56 | 15.83 | 17 | 26347 | 104142 | 50474618 |
Osteoarthritis | 17.35 | 15.83 | 7 | 26357 | 68599 | 50510161 |
Micrognathia | 17.33 | 15.83 | 6 | 26358 | 235 | 50578525 |
Cleft lip | 17.27 | 15.83 | 5 | 26359 | 108 | 50578652 |
Thrombosis | 17.16 | 15.83 | 4 | 26360 | 55829 | 50522931 |
Acute lymphocytic leukaemia | 17.13 | 15.83 | 12 | 26352 | 2229 | 50576531 |
Nasal congestion | 17.09 | 15.83 | 3 | 26361 | 51117 | 50527643 |
Cervical dysplasia | 16.96 | 15.83 | 13 | 26351 | 2772 | 50575988 |
Persistent left superior vena cava | 16.86 | 15.83 | 4 | 26360 | 38 | 50578722 |
Developmental coordination disorder | 16.86 | 15.83 | 4 | 26360 | 38 | 50578722 |
Acute fatty liver of pregnancy | 16.76 | 15.83 | 4 | 26360 | 39 | 50578721 |
Genital prolapse | 16.67 | 15.83 | 4 | 26360 | 40 | 50578720 |
Nodular regenerative hyperplasia | 16.62 | 15.83 | 6 | 26358 | 266 | 50578494 |
Oropharyngeal pain | 16.56 | 15.83 | 10 | 26354 | 77791 | 50500969 |
Blood alkaline phosphatase increased | 16.52 | 15.83 | 50 | 26314 | 37476 | 50541284 |
Intentional overdose | 16.43 | 15.83 | 6 | 26358 | 62498 | 50516262 |
Glycocholic acid increased | 16.39 | 15.83 | 3 | 26361 | 6 | 50578754 |
Carbon dioxide combining power abnormal | 16.39 | 15.83 | 3 | 26361 | 6 | 50578754 |
Growth hormone-producing pituitary tumour | 16.39 | 15.83 | 3 | 26361 | 6 | 50578754 |
Infected vasculitis | 16.39 | 15.83 | 3 | 26361 | 6 | 50578754 |
Anaphylactic reaction | 16.37 | 15.83 | 4 | 26360 | 54051 | 50524709 |
Threatened labour | 16.18 | 15.83 | 8 | 26356 | 779 | 50577981 |
Defaecation urgency | 15.98 | 15.83 | 13 | 26351 | 3020 | 50575740 |
Foetal heart rate abnormal | 15.96 | 15.83 | 7 | 26357 | 519 | 50578241 |
Neck pain | 15.83 | 15.83 | 5 | 26359 | 57062 | 50521698 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Viral mutation identified | 1707.49 | 12.38 | 450 | 44412 | 2038 | 29527627 |
Virologic failure | 1494.97 | 12.38 | 417 | 44445 | 2430 | 29527235 |
Immune reconstitution inflammatory syndrome | 1465.56 | 12.38 | 521 | 44341 | 7281 | 29522384 |
Pathogen resistance | 1263.81 | 12.38 | 472 | 44390 | 7644 | 29522021 |
Drug resistance | 926.61 | 12.38 | 510 | 44352 | 21030 | 29508635 |
Lipodystrophy acquired | 793.22 | 12.38 | 261 | 44601 | 2833 | 29526832 |
Foetal exposure during pregnancy | 691.37 | 12.38 | 500 | 44362 | 33367 | 29496298 |
Hepatitis B | 609.14 | 12.38 | 250 | 44612 | 5247 | 29524418 |
Drug interaction | 569.41 | 12.38 | 1047 | 43815 | 196338 | 29333327 |
Exposure during pregnancy | 554.15 | 12.38 | 267 | 44595 | 8287 | 29521378 |
Depression | 553.84 | 12.38 | 663 | 44199 | 84484 | 29445181 |
Mitochondrial toxicity | 463.66 | 12.38 | 164 | 44698 | 2247 | 29527418 |
Hepatitis B DNA increased | 365.12 | 12.38 | 95 | 44767 | 403 | 29529262 |
Osteomalacia | 346.54 | 12.38 | 103 | 44759 | 773 | 29528892 |
Hepatitis B reactivation | 337.85 | 12.38 | 141 | 44721 | 3088 | 29526577 |
Acquired gene mutation | 313.84 | 12.38 | 104 | 44758 | 1154 | 29528511 |
Eyelid ptosis | 291.47 | 12.38 | 147 | 44715 | 5039 | 29524626 |
Fanconi syndrome acquired | 282.32 | 12.38 | 106 | 44756 | 1736 | 29527929 |
Viral load increased | 257.29 | 12.38 | 102 | 44760 | 1947 | 29527718 |
Blood HIV RNA increased | 248.84 | 12.38 | 83 | 44779 | 941 | 29528724 |
Progressive external ophthalmoplegia | 217.27 | 12.38 | 80 | 44782 | 1237 | 29528428 |
Lipoatrophy | 208.77 | 12.38 | 61 | 44801 | 428 | 29529237 |
Pinealoblastoma | 199.64 | 12.38 | 48 | 44814 | 135 | 29529530 |
Premature baby | 191.36 | 12.38 | 179 | 44683 | 17101 | 29512564 |
Hypophosphataemia | 189.32 | 12.38 | 129 | 44733 | 7795 | 29521870 |
Hypertriglyceridaemia | 188.90 | 12.38 | 126 | 44736 | 7349 | 29522316 |
Hepatic failure | 177.94 | 12.38 | 229 | 44633 | 31283 | 29498382 |
Diplopia | 171.18 | 12.38 | 151 | 44711 | 13367 | 29516298 |
Fanconi syndrome | 164.53 | 12.38 | 69 | 44793 | 1529 | 29528136 |
Hepatic fibrosis | 159.13 | 12.38 | 84 | 44778 | 3168 | 29526497 |
Genotype drug resistance test | 154.68 | 12.38 | 33 | 44829 | 41 | 29529624 |
Renal tubular disorder | 151.80 | 12.38 | 90 | 44772 | 4262 | 29525403 |
Kaposi's sarcoma | 148.26 | 12.38 | 54 | 44808 | 808 | 29528857 |
CD4 lymphocytes decreased | 147.97 | 12.38 | 64 | 44798 | 1534 | 29528131 |
Multiple-drug resistance | 129.14 | 12.38 | 78 | 44784 | 3822 | 29525843 |
Osteoporosis | 123.93 | 12.38 | 114 | 44748 | 10655 | 29519010 |
Off label use | 121.36 | 12.38 | 168 | 44694 | 300632 | 29229033 |
Polydactyly | 119.97 | 12.38 | 50 | 44812 | 1090 | 29528575 |
Meningitis cryptococcal | 119.37 | 12.38 | 60 | 44802 | 2040 | 29527625 |
Treatment failure | 118.48 | 12.38 | 206 | 44656 | 36733 | 29492932 |
Fall | 117.79 | 12.38 | 61 | 44801 | 177117 | 29352548 |
Alanine aminotransferase increased | 116.63 | 12.38 | 301 | 44561 | 70643 | 29459022 |
Gene mutation | 114.09 | 12.38 | 47 | 44815 | 994 | 29528671 |
Retinal toxicity | 111.26 | 12.38 | 36 | 44826 | 368 | 29529297 |
Trisomy 21 | 107.10 | 12.38 | 37 | 44825 | 470 | 29529195 |
Maternal drugs affecting foetus | 104.12 | 12.38 | 68 | 44794 | 3825 | 29525840 |
Portal hypertension | 100.91 | 12.38 | 64 | 44798 | 3422 | 29526243 |
HIV-associated neurocognitive disorder | 98.45 | 12.38 | 31 | 44831 | 288 | 29529377 |
Treatment noncompliance | 97.87 | 12.38 | 150 | 44712 | 24077 | 29505588 |
Blood phosphorus decreased | 95.58 | 12.38 | 57 | 44805 | 2728 | 29526937 |
Loss of personal independence in daily activities | 95.11 | 12.38 | 152 | 44710 | 25288 | 29504377 |
Product dose omission issue | 95.00 | 12.38 | 16 | 44846 | 96367 | 29433298 |
Hepatic cirrhosis | 94.37 | 12.38 | 113 | 44749 | 14331 | 29515334 |
Nephropathy toxic | 94.09 | 12.38 | 98 | 44764 | 10658 | 29519007 |
Completed suicide | 93.46 | 12.38 | 13 | 44849 | 90233 | 29439432 |
Blood lactic acid increased | 92.81 | 12.38 | 74 | 44788 | 5692 | 29523973 |
Mycobacterium avium complex infection | 92.66 | 12.38 | 52 | 44810 | 2217 | 29527448 |
Hyperlactacidaemia | 92.40 | 12.38 | 55 | 44807 | 2623 | 29527042 |
Osteonecrosis | 92.02 | 12.38 | 108 | 44754 | 13411 | 29516254 |
Death | 90.89 | 12.38 | 245 | 44617 | 341839 | 29187826 |
Jaundice | 89.56 | 12.38 | 160 | 44702 | 29136 | 29500529 |
Cytomegalovirus chorioretinitis | 85.23 | 12.38 | 56 | 44806 | 3182 | 29526483 |
Pneumonia | 84.49 | 12.38 | 230 | 44632 | 319942 | 29209723 |
Mitochondrial cytopathy | 83.58 | 12.38 | 24 | 44838 | 157 | 29529508 |
Hyperlipidaemia | 83.08 | 12.38 | 99 | 44763 | 12491 | 29517174 |
Renal tubular dysfunction | 82.85 | 12.38 | 29 | 44833 | 384 | 29529281 |
Hypouricaemia | 79.23 | 12.38 | 25 | 44837 | 234 | 29529431 |
Aspartate aminotransferase increased | 77.92 | 12.38 | 233 | 44629 | 59492 | 29470173 |
Hypotension | 77.75 | 12.38 | 109 | 44753 | 194245 | 29335420 |
Volvulus | 77.20 | 12.38 | 37 | 44825 | 1132 | 29528533 |
Drug abuse | 77.09 | 12.38 | 14 | 44848 | 79869 | 29449796 |
Peripheral swelling | 76.97 | 12.38 | 5 | 44857 | 63734 | 29465931 |
Drug-induced liver injury | 76.34 | 12.38 | 126 | 44736 | 21529 | 29508136 |
Dyspnoea | 75.91 | 12.38 | 249 | 44613 | 326483 | 29203182 |
CSF HIV escape syndrome | 74.13 | 12.38 | 22 | 44840 | 164 | 29529501 |
Neonatal disorder | 73.82 | 12.38 | 32 | 44830 | 771 | 29528894 |
Proteinuria | 72.66 | 12.38 | 104 | 44758 | 15700 | 29513965 |
Hepatitis C | 72.29 | 12.38 | 78 | 44784 | 8832 | 29520833 |
Pulmonary tuberculosis | 70.78 | 12.38 | 56 | 44806 | 4259 | 29525406 |
Acquired immunodeficiency syndrome | 70.66 | 12.38 | 26 | 44836 | 401 | 29529264 |
Anaemia macrocytic | 68.07 | 12.38 | 45 | 44817 | 2583 | 29527082 |
Hepatitis | 68.04 | 12.38 | 117 | 44745 | 20666 | 29508999 |
HIV infection | 67.88 | 12.38 | 34 | 44828 | 1147 | 29528518 |
Hepatomegaly | 66.02 | 12.38 | 76 | 44786 | 9241 | 29520424 |
Renal impairment | 65.08 | 12.38 | 270 | 44592 | 81063 | 29448602 |
Blood alkaline phosphatase increased | 64.66 | 12.38 | 137 | 44725 | 28269 | 29501396 |
Fatigue | 63.92 | 12.38 | 256 | 44606 | 316565 | 29213100 |
Lymphadenopathy | 63.13 | 12.38 | 126 | 44736 | 24923 | 29504742 |
Glycosuria | 62.54 | 12.38 | 32 | 44830 | 1130 | 29528535 |
Caesarean section | 62.48 | 12.38 | 38 | 44824 | 1885 | 29527780 |
Ophthalmoplegia | 61.85 | 12.38 | 36 | 44826 | 1646 | 29528019 |
Hepatic function abnormal | 61.81 | 12.38 | 164 | 44698 | 39095 | 29490570 |
Oesophageal candidiasis | 61.41 | 12.38 | 49 | 44813 | 3772 | 29525893 |
Hyperbilirubinaemia | 61.05 | 12.38 | 93 | 44769 | 14841 | 29514824 |
Varices oesophageal | 60.76 | 12.38 | 45 | 44817 | 3101 | 29526564 |
Congenital umbilical hernia | 60.41 | 12.38 | 21 | 44841 | 272 | 29529393 |
Tuberculosis | 60.14 | 12.38 | 64 | 44798 | 7132 | 29522533 |
Dyslipidaemia | 59.90 | 12.38 | 59 | 44803 | 6002 | 29523663 |
Malignant neoplasm progression | 59.42 | 12.38 | 19 | 44843 | 73840 | 29455825 |
Birth mark | 58.79 | 12.38 | 18 | 44844 | 151 | 29529514 |
Congenital anomaly | 58.52 | 12.38 | 32 | 44830 | 1296 | 29528369 |
Pain | 58.29 | 12.38 | 107 | 44755 | 171325 | 29358340 |
Progressive multifocal leukoencephalopathy | 58.24 | 12.38 | 69 | 44793 | 8650 | 29521015 |
Urine phosphorus increased | 57.81 | 12.38 | 14 | 44848 | 41 | 29529624 |
Lactic acidosis | 57.75 | 12.38 | 136 | 44726 | 30111 | 29499554 |
Blood pressure increased | 57.60 | 12.38 | 20 | 44842 | 73783 | 29455882 |
Blood bilirubin increased | 55.82 | 12.38 | 144 | 44718 | 33749 | 29495916 |
Constipation | 55.25 | 12.38 | 55 | 44807 | 114105 | 29415560 |
Hepatocellular carcinoma | 54.28 | 12.38 | 60 | 44802 | 6978 | 29522687 |
Lipohypertrophy | 54.28 | 12.38 | 18 | 44844 | 200 | 29529465 |
Hepatosplenomegaly | 52.06 | 12.38 | 44 | 44818 | 3673 | 29525992 |
Hepatic cancer | 51.46 | 12.38 | 56 | 44806 | 6400 | 29523265 |
Calculus urinary | 51.45 | 12.38 | 28 | 44834 | 1123 | 29528542 |
Pregnancy | 51.10 | 12.38 | 18 | 44844 | 243 | 29529422 |
Atrial fibrillation | 51.00 | 12.38 | 51 | 44811 | 105595 | 29424070 |
Blood triglycerides increased | 49.77 | 12.38 | 78 | 44784 | 12756 | 29516909 |
Talipes | 49.63 | 12.38 | 32 | 44830 | 1760 | 29527905 |
Genotype drug resistance test positive | 48.84 | 12.38 | 26 | 44836 | 997 | 29528668 |
Human immunodeficiency virus transmission | 48.04 | 12.38 | 11 | 44851 | 23 | 29529642 |
CD4 lymphocytes increased | 46.26 | 12.38 | 16 | 44846 | 204 | 29529461 |
Gamma-glutamyltransferase increased | 45.47 | 12.38 | 115 | 44747 | 26622 | 29503043 |
Cachexia | 45.34 | 12.38 | 52 | 44810 | 6297 | 29523368 |
Hepatic encephalopathy | 44.80 | 12.38 | 75 | 44787 | 12960 | 29516705 |
Cryptococcosis | 44.77 | 12.38 | 31 | 44831 | 1921 | 29527744 |
Dandy-Walker syndrome | 44.37 | 12.38 | 14 | 44848 | 131 | 29529534 |
Oesophageal varices haemorrhage | 44.17 | 12.38 | 35 | 44827 | 2667 | 29526998 |
Pyelocaliectasis | 44.16 | 12.38 | 25 | 44837 | 1084 | 29528581 |
Hepatitis B virus test | 43.94 | 12.38 | 8 | 44854 | 0 | 29529665 |
Facial wasting | 43.81 | 12.38 | 14 | 44848 | 137 | 29529528 |
Nasopharyngitis | 43.49 | 12.38 | 18 | 44844 | 59647 | 29470018 |
Multiple fractures | 42.87 | 12.38 | 26 | 44836 | 1283 | 29528382 |
Inappropriate schedule of product administration | 42.44 | 12.38 | 8 | 44854 | 44464 | 29485201 |
Opportunistic infection | 42.25 | 12.38 | 27 | 44835 | 1462 | 29528203 |
Optic nerve neoplasm | 42.16 | 12.38 | 10 | 44852 | 26 | 29529639 |
Nephrolithiasis | 42.08 | 12.38 | 108 | 44754 | 25226 | 29504439 |
Anaemia neonatal | 42.00 | 12.38 | 16 | 44846 | 273 | 29529392 |
Infusion related reaction | 41.66 | 12.38 | 8 | 44854 | 43878 | 29485787 |
Oral candidiasis | 41.34 | 12.38 | 65 | 44797 | 10657 | 29519008 |
Congenital neoplasm | 41.11 | 12.38 | 10 | 44852 | 30 | 29529635 |
Cerebral toxoplasmosis | 40.99 | 12.38 | 26 | 44836 | 1390 | 29528275 |
Blood bilirubin unconjugated increased | 40.93 | 12.38 | 19 | 44843 | 540 | 29529125 |
Basedow's disease | 40.79 | 12.38 | 11 | 44851 | 55 | 29529610 |
Cryptorchism | 40.27 | 12.38 | 29 | 44833 | 1913 | 29527752 |
Splenomegaly | 39.89 | 12.38 | 72 | 44790 | 13207 | 29516458 |
Immune reconstitution inflammatory syndrome associated tuberculosis | 39.82 | 12.38 | 17 | 44845 | 394 | 29529271 |
Small for dates baby | 39.45 | 12.38 | 37 | 44825 | 3542 | 29526123 |
Bone density decreased | 39.29 | 12.38 | 27 | 44835 | 1653 | 29528012 |
Cardiac failure congestive | 39.25 | 12.38 | 35 | 44827 | 76546 | 29453119 |
Feeling abnormal | 38.77 | 12.38 | 17 | 44845 | 54428 | 29475237 |
Ascites | 38.74 | 12.38 | 133 | 44729 | 36486 | 29493179 |
Urine calcium increased | 38.70 | 12.38 | 10 | 44852 | 41 | 29529624 |
Confusional state | 38.16 | 12.38 | 86 | 44776 | 127791 | 29401874 |
Joint swelling | 37.78 | 12.38 | 14 | 44848 | 49616 | 29480049 |
Rhabdomyosarcoma | 37.51 | 12.38 | 9 | 44853 | 25 | 29529640 |
Mycobacterium avium complex immune restoration disease | 37.25 | 12.38 | 9 | 44853 | 26 | 29529639 |
Aminoaciduria | 37.14 | 12.38 | 12 | 44850 | 122 | 29529543 |
Pneumocystis jirovecii pneumonia | 37.10 | 12.38 | 80 | 44782 | 16699 | 29512966 |
Mycobacterial infection | 36.86 | 12.38 | 27 | 44835 | 1829 | 29527836 |
Acute hepatitis C | 36.06 | 12.38 | 11 | 44851 | 91 | 29529574 |
Mitochondrial myopathy | 35.90 | 12.38 | 13 | 44849 | 191 | 29529474 |
Cardio-respiratory arrest | 35.71 | 12.38 | 16 | 44846 | 50585 | 29479080 |
Nodular regenerative hyperplasia | 34.43 | 12.38 | 18 | 44844 | 665 | 29529000 |
Liver disorder | 34.04 | 12.38 | 106 | 44756 | 27643 | 29502022 |
Wheezing | 33.89 | 12.38 | 5 | 44857 | 33235 | 29496430 |
Hepatotoxicity | 33.73 | 12.38 | 80 | 44782 | 17787 | 29511878 |
Blood phosphorus abnormal | 33.69 | 12.38 | 11 | 44851 | 116 | 29529549 |
Osteoporotic fracture | 33.27 | 12.38 | 20 | 44842 | 971 | 29528694 |
Cardiac arrest | 33.16 | 12.38 | 49 | 44813 | 85542 | 29444123 |
Renal tubular acidosis | 33.06 | 12.38 | 25 | 44837 | 1778 | 29527887 |
Transaminases increased | 32.98 | 12.38 | 92 | 44770 | 22570 | 29507095 |
Cerebrovascular accident | 32.86 | 12.38 | 41 | 44821 | 76870 | 29452795 |
Death neonatal | 32.77 | 12.38 | 14 | 44848 | 325 | 29529340 |
Blood pyruvic acid increased | 32.25 | 12.38 | 7 | 44855 | 10 | 29529655 |
Viraemia | 31.79 | 12.38 | 20 | 44842 | 1054 | 29528611 |
Dizziness | 31.71 | 12.38 | 164 | 44698 | 189520 | 29340145 |
Intentional product misuse | 31.49 | 12.38 | 7 | 44855 | 34654 | 29495011 |
Thrombosis | 31.34 | 12.38 | 13 | 44849 | 43032 | 29486633 |
Oesophageal atresia | 31.32 | 12.38 | 15 | 44847 | 458 | 29529207 |
Hydrocele | 31.29 | 12.38 | 25 | 44837 | 1928 | 29527737 |
Congenital hydronephrosis | 31.14 | 12.38 | 17 | 44845 | 686 | 29528979 |
Anaemia | 31.13 | 12.38 | 452 | 44410 | 200499 | 29329166 |
Contusion | 30.97 | 12.38 | 5 | 44857 | 31090 | 29498575 |
Toxicity to various agents | 30.83 | 12.38 | 147 | 44715 | 173514 | 29356151 |
Disease progression | 30.67 | 12.38 | 48 | 44814 | 81868 | 29447797 |
Cushing's syndrome | 30.52 | 12.38 | 14 | 44848 | 387 | 29529278 |
Flushing | 30.41 | 12.38 | 4 | 44858 | 28988 | 29500677 |
Epistaxis | 29.80 | 12.38 | 21 | 44841 | 51683 | 29477982 |
Hepatitis cholestatic | 29.70 | 12.38 | 44 | 44818 | 6849 | 29522816 |
White matter lesion | 29.58 | 12.38 | 16 | 44846 | 634 | 29529031 |
HIV lipodystrophy | 29.57 | 12.38 | 7 | 44855 | 18 | 29529647 |
Osteopenia | 29.53 | 12.38 | 34 | 44828 | 4134 | 29525531 |
Stevens-Johnson syndrome | 29.14 | 12.38 | 72 | 44790 | 16425 | 29513240 |
Astrocytoma, low grade | 29.03 | 12.38 | 8 | 44854 | 44 | 29529621 |
Therapeutic product effect decreased | 28.74 | 12.38 | 5 | 44857 | 29446 | 29500219 |
HIV viraemia | 28.74 | 12.38 | 8 | 44854 | 46 | 29529619 |
Tremor | 28.58 | 12.38 | 42 | 44820 | 73496 | 29456169 |
Febrile neutropenia | 28.44 | 12.38 | 82 | 44780 | 112158 | 29417507 |
Lactate pyruvate ratio increased | 28.33 | 12.38 | 6 | 44856 | 7 | 29529658 |
Vanishing bile duct syndrome | 28.23 | 12.38 | 15 | 44847 | 573 | 29529092 |
Somnolence | 28.16 | 12.38 | 63 | 44799 | 93892 | 29435773 |
Drug ineffective | 27.54 | 12.38 | 387 | 44475 | 362783 | 29166882 |
Muscle spasms | 27.48 | 12.38 | 35 | 44827 | 65047 | 29464618 |
Mitochondrial DNA depletion | 27.46 | 12.38 | 5 | 44857 | 0 | 29529665 |
Chronic obstructive pulmonary disease | 27.29 | 12.38 | 14 | 44848 | 40941 | 29488724 |
Tubulointerstitial nephritis | 27.04 | 12.38 | 73 | 44789 | 17570 | 29512095 |
Atrioventricular septal defect | 27.01 | 12.38 | 10 | 44852 | 157 | 29529508 |
Hyperhidrosis | 26.94 | 12.38 | 35 | 44827 | 64505 | 29465160 |
Injection site pain | 26.70 | 12.38 | 8 | 44854 | 32438 | 29497227 |
Meningomyelocele | 26.61 | 12.38 | 10 | 44852 | 164 | 29529501 |
Blood uric acid increased | 26.57 | 12.38 | 38 | 44824 | 5730 | 29523935 |
Bone metabolism disorder | 26.55 | 12.38 | 11 | 44851 | 236 | 29529429 |
Retroviral rebound syndrome | 26.38 | 12.38 | 6 | 44856 | 12 | 29529653 |
Low set ears | 26.35 | 12.38 | 13 | 44849 | 424 | 29529241 |
Product use in unapproved indication | 26.24 | 12.38 | 58 | 44804 | 86817 | 29442848 |
Lymph node tuberculosis | 26.16 | 12.38 | 13 | 44849 | 431 | 29529234 |
Hepatitis A | 26.05 | 12.38 | 13 | 44849 | 435 | 29529230 |
Viral load decreased | 25.96 | 12.38 | 7 | 44855 | 35 | 29529630 |
Cardiac disorder | 25.95 | 12.38 | 12 | 44850 | 37251 | 29492414 |
Fat tissue increased | 25.95 | 12.38 | 12 | 44850 | 338 | 29529327 |
Hypophosphataemic osteomalacia | 25.86 | 12.38 | 9 | 44853 | 117 | 29529548 |
Congenital central nervous system anomaly | 25.86 | 12.38 | 13 | 44849 | 442 | 29529223 |
Neurosyphilis | 25.80 | 12.38 | 7 | 44855 | 36 | 29529629 |
Prenatal screening test abnormal | 25.75 | 12.38 | 6 | 44856 | 14 | 29529651 |
Hypospadias | 25.62 | 12.38 | 27 | 44835 | 2975 | 29526690 |
Beta 2 microglobulin urine increased | 25.25 | 12.38 | 8 | 44854 | 76 | 29529589 |
Bone pain | 24.99 | 12.38 | 73 | 44789 | 18379 | 29511286 |
Anxiety | 24.97 | 12.38 | 58 | 44804 | 85307 | 29444358 |
HIV test positive | 24.93 | 12.38 | 9 | 44853 | 131 | 29529534 |
Syncope | 24.84 | 12.38 | 54 | 44808 | 81317 | 29448348 |
Neonatal asphyxia | 24.78 | 12.38 | 11 | 44851 | 281 | 29529384 |
Limb deformity | 24.46 | 12.38 | 13 | 44849 | 497 | 29529168 |
HIV wasting syndrome | 24.45 | 12.38 | 8 | 44854 | 85 | 29529580 |
Pyrexia | 24.32 | 12.38 | 589 | 44273 | 287033 | 29242632 |
Plasma cell myeloma | 24.27 | 12.38 | 13 | 44849 | 37102 | 29492563 |
Cardiac failure | 23.89 | 12.38 | 53 | 44809 | 79234 | 29450431 |
Blood glucose increased | 23.59 | 12.38 | 33 | 44829 | 58951 | 29470714 |
Product use issue | 23.49 | 12.38 | 26 | 44836 | 51418 | 29478247 |
Unevaluable event | 23.43 | 12.38 | 8 | 44854 | 29843 | 29499822 |
Cellulitis | 23.42 | 12.38 | 21 | 44841 | 45819 | 29483846 |
Congenital cytomegalovirus infection | 23.34 | 12.38 | 6 | 44856 | 24 | 29529641 |
Toxoplasmosis | 23.23 | 12.38 | 17 | 44845 | 1150 | 29528515 |
Anogenital warts | 23.21 | 12.38 | 13 | 44849 | 552 | 29529113 |
Atypical mycobacterial infection | 23.15 | 12.38 | 14 | 44848 | 687 | 29528978 |
Spider naevus | 22.95 | 12.38 | 6 | 44856 | 26 | 29529639 |
Tuberculoid leprosy | 22.83 | 12.38 | 7 | 44855 | 59 | 29529606 |
Anal cancer | 22.46 | 12.38 | 11 | 44851 | 353 | 29529312 |
Stress | 22.45 | 12.38 | 3 | 44859 | 21487 | 29508178 |
Incorrect dose administered | 22.39 | 12.38 | 11 | 44851 | 32973 | 29496692 |
Amoebiasis | 22.33 | 12.38 | 7 | 44855 | 64 | 29529601 |
Intracranial pressure increased | 22.32 | 12.38 | 27 | 44835 | 3458 | 29526207 |
Urinary tract infection | 22.10 | 12.38 | 48 | 44814 | 72306 | 29457359 |
Meningitis tuberculous | 21.99 | 12.38 | 13 | 44849 | 612 | 29529053 |
Trimethylaminuria | 21.99 | 12.38 | 5 | 44857 | 10 | 29529655 |
Withdrawal hepatitis | 21.97 | 12.38 | 4 | 44858 | 0 | 29529665 |
Strongyloidiasis | 21.91 | 12.38 | 22 | 44840 | 2290 | 29527375 |
Hepatitis D | 21.63 | 12.38 | 6 | 44856 | 34 | 29529631 |
Live birth | 21.47 | 12.38 | 9 | 44853 | 199 | 29529466 |
Parotid gland enlargement | 21.45 | 12.38 | 10 | 44852 | 287 | 29529378 |
Hypercholesterolaemia | 21.42 | 12.38 | 39 | 44823 | 7199 | 29522466 |
Cardiac murmur | 21.33 | 12.38 | 37 | 44825 | 6576 | 29523089 |
Histoplasmosis disseminated | 21.28 | 12.38 | 16 | 44846 | 1128 | 29528537 |
Chest discomfort | 21.26 | 12.38 | 23 | 44839 | 45960 | 29483705 |
Antimitochondrial antibody positive | 21.20 | 12.38 | 6 | 44856 | 37 | 29529628 |
Hepatitis B surface antigen positive | 21.19 | 12.38 | 8 | 44854 | 133 | 29529532 |
Angioedema | 21.13 | 12.38 | 11 | 44851 | 31904 | 29497761 |
Night blindness | 20.95 | 12.38 | 9 | 44853 | 212 | 29529453 |
Blood creatine phosphokinase increased | 20.94 | 12.38 | 119 | 44743 | 40525 | 29489140 |
Cryoglobulinaemia | 20.92 | 12.38 | 10 | 44852 | 304 | 29529361 |
Blood creatinine increased | 20.86 | 12.38 | 209 | 44653 | 84893 | 29444772 |
Umbilical cord abnormality | 20.80 | 12.38 | 6 | 44856 | 40 | 29529625 |
Granulomatous rosacea | 20.76 | 12.38 | 8 | 44854 | 141 | 29529524 |
Foetal growth restriction | 20.65 | 12.38 | 27 | 44835 | 3739 | 29525926 |
Macrocytosis | 20.46 | 12.38 | 14 | 44848 | 851 | 29528814 |
Influenza | 20.44 | 12.38 | 20 | 44842 | 41861 | 29487804 |
Chest pain | 20.30 | 12.38 | 94 | 44768 | 111879 | 29417786 |
Gynaecomastia | 20.29 | 12.38 | 41 | 44821 | 8176 | 29521489 |
Urine phosphorus decreased | 20.18 | 12.38 | 6 | 44856 | 45 | 29529620 |
Haematochezia | 20.05 | 12.38 | 16 | 44846 | 36967 | 29492698 |
Neuromyopathy | 19.97 | 12.38 | 14 | 44848 | 885 | 29528780 |
Exomphalos | 19.97 | 12.38 | 8 | 44854 | 157 | 29529508 |
Primary syphilis | 19.86 | 12.38 | 5 | 44857 | 18 | 29529647 |
Bacterial pyelonephritis | 19.81 | 12.38 | 9 | 44853 | 243 | 29529422 |
Prostate cancer | 19.76 | 12.38 | 7 | 44855 | 25520 | 29504145 |
Bradycardia | 19.66 | 12.38 | 44 | 44818 | 65585 | 29464080 |
AIDS related complication | 19.65 | 12.38 | 5 | 44857 | 19 | 29529646 |
Normal newborn | 19.56 | 12.38 | 8 | 44854 | 166 | 29529499 |
Urticaria | 19.54 | 12.38 | 33 | 44829 | 54627 | 29475038 |
Oropharyngeal pain | 19.52 | 12.38 | 10 | 44852 | 29275 | 29500390 |
Diaphragmatic hernia | 19.45 | 12.38 | 9 | 44853 | 254 | 29529411 |
Weight increased | 19.41 | 12.38 | 56 | 44806 | 76611 | 29453054 |
Taeniasis | 19.32 | 12.38 | 6 | 44856 | 53 | 29529612 |
Pulmonary embolism | 19.31 | 12.38 | 56 | 44806 | 76478 | 29453187 |
Perinatal HIV infection | 19.20 | 12.38 | 4 | 44858 | 4 | 29529661 |
Maternal condition affecting foetus | 19.20 | 12.38 | 4 | 44858 | 4 | 29529661 |
Liver transplant rejection | 19.10 | 12.38 | 19 | 44843 | 1955 | 29527710 |
Pancreatitis | 19.08 | 12.38 | 103 | 44759 | 34411 | 29495254 |
Oropharyngeal candidiasis | 18.93 | 12.38 | 12 | 44850 | 641 | 29529024 |
Pilonidal cyst congenital | 18.88 | 12.38 | 5 | 44857 | 23 | 29529642 |
Hyperphosphatasaemia | 18.88 | 12.38 | 5 | 44857 | 23 | 29529642 |
Visual field defect | 18.78 | 12.38 | 27 | 44835 | 4089 | 29525576 |
Malaria | 18.68 | 12.38 | 8 | 44854 | 187 | 29529478 |
Rectal haemorrhage | 18.66 | 12.38 | 15 | 44847 | 34534 | 29495131 |
International normalised ratio increased | 18.58 | 12.38 | 24 | 44838 | 44348 | 29485317 |
Developmental hip dysplasia | 18.58 | 12.38 | 9 | 44853 | 282 | 29529383 |
Hyperkalaemia | 18.52 | 12.38 | 41 | 44821 | 61351 | 29468314 |
Chordee | 18.48 | 12.38 | 6 | 44856 | 62 | 29529603 |
Pruritus | 18.40 | 12.38 | 103 | 44759 | 116746 | 29412919 |
Cerebral ventricle dilatation | 18.33 | 12.38 | 13 | 44849 | 837 | 29528828 |
Agitation | 18.31 | 12.38 | 31 | 44831 | 51273 | 29478392 |
Borderline leprosy | 18.31 | 12.38 | 4 | 44858 | 6 | 29529659 |
Hepatitis C virus test | 18.31 | 12.38 | 6 | 44856 | 64 | 29529601 |
Hospitalisation | 18.12 | 12.38 | 26 | 44836 | 45962 | 29483703 |
Oxygen saturation decreased | 18.11 | 12.38 | 25 | 44837 | 44912 | 29484753 |
Gastrointestinal haemorrhage | 18.08 | 12.38 | 61 | 44801 | 79472 | 29450193 |
Asymptomatic viral hepatitis | 18.07 | 12.38 | 5 | 44857 | 28 | 29529637 |
Blood uric acid decreased | 18.06 | 12.38 | 9 | 44853 | 300 | 29529365 |
Hepatitis B DNA assay positive | 17.99 | 12.38 | 6 | 44856 | 68 | 29529597 |
Abdominal discomfort | 17.99 | 12.38 | 28 | 44834 | 47875 | 29481790 |
Interstitial lung disease | 17.86 | 12.38 | 38 | 44824 | 57680 | 29471985 |
Wrong technique in product usage process | 17.79 | 12.38 | 13 | 44849 | 31415 | 29498250 |
Lower respiratory tract infection | 17.74 | 12.38 | 9 | 44853 | 26493 | 29503172 |
Sickle cell disease | 17.73 | 12.38 | 7 | 44855 | 132 | 29529533 |
Meconium ileus | 17.64 | 12.38 | 5 | 44857 | 31 | 29529634 |
Crystal urine | 17.60 | 12.38 | 6 | 44856 | 73 | 29529592 |
Renal atrophy | 17.60 | 12.38 | 14 | 44848 | 1073 | 29528592 |
Loss of anatomical alignment after fracture reduction | 17.59 | 12.38 | 4 | 44858 | 8 | 29529657 |
Neonatal pneumothorax | 17.59 | 12.38 | 4 | 44858 | 8 | 29529657 |
Subchondral insufficiency fracture | 17.59 | 12.38 | 4 | 44858 | 8 | 29529657 |
Drug dependence | 17.58 | 12.38 | 5 | 44857 | 20976 | 29508689 |
Cataract | 17.56 | 12.38 | 6 | 44856 | 22372 | 29507293 |
Hepatic cytolysis | 17.54 | 12.38 | 39 | 44823 | 8308 | 29521357 |
Bronchitis | 17.54 | 12.38 | 18 | 44844 | 36850 | 29492815 |
Heart rate increased | 17.42 | 12.38 | 20 | 44842 | 38918 | 29490747 |
Pneumonia aspiration | 17.40 | 12.38 | 18 | 44844 | 36719 | 29492946 |
Psoriasis | 17.39 | 12.38 | 14 | 44848 | 32213 | 29497452 |
Erosive duodenitis | 17.34 | 12.38 | 15 | 44847 | 1292 | 29528373 |
Diverticulitis | 17.29 | 12.38 | 3 | 44859 | 17701 | 29511964 |
Creutzfeldt-Jakob disease | 17.24 | 12.38 | 5 | 44857 | 34 | 29529631 |
Lymphocytic infiltration | 17.24 | 12.38 | 11 | 44851 | 594 | 29529071 |
Persistent foetal circulation | 17.18 | 12.38 | 9 | 44853 | 334 | 29529331 |
Bulbar palsy | 17.12 | 12.38 | 8 | 44854 | 231 | 29529434 |
White blood cell count increased | 17.08 | 12.38 | 19 | 44843 | 37497 | 29492168 |
Optic atrophy | 17.07 | 12.38 | 12 | 44850 | 762 | 29528903 |
ADAMTS13 activity decreased | 17.03 | 12.38 | 6 | 44856 | 81 | 29529584 |
Encephalitis | 16.98 | 12.38 | 33 | 44829 | 6397 | 29523268 |
Retinoblastoma | 16.98 | 12.38 | 4 | 44858 | 10 | 29529655 |
Acquired aminoaciduria | 16.98 | 12.38 | 4 | 44858 | 10 | 29529655 |
Haematoma | 16.91 | 12.38 | 7 | 44855 | 23205 | 29506460 |
Alpha 1 foetoprotein increased | 16.82 | 12.38 | 11 | 44851 | 620 | 29529045 |
Delirium | 16.82 | 12.38 | 21 | 44841 | 39376 | 29490289 |
Femoral neck fracture | 16.80 | 12.38 | 21 | 44841 | 2782 | 29526883 |
Hepatic enzyme increased | 16.79 | 12.38 | 98 | 44764 | 33701 | 29495964 |
Glucose urine present | 16.76 | 12.38 | 13 | 44849 | 960 | 29528705 |
Coccidioidomycosis | 16.74 | 12.38 | 11 | 44851 | 625 | 29529040 |
Fracture malunion | 16.70 | 12.38 | 4 | 44858 | 11 | 29529654 |
Blood pressure decreased | 16.68 | 12.38 | 27 | 44835 | 45450 | 29484215 |
Bone marrow oedema | 16.61 | 12.38 | 10 | 44852 | 487 | 29529178 |
Liver transplant | 16.59 | 12.38 | 19 | 44843 | 2297 | 29527368 |
Dehydration | 16.56 | 12.38 | 104 | 44758 | 114644 | 29415021 |
Arthropathy | 16.53 | 12.38 | 6 | 44856 | 21548 | 29508117 |
Meconium stain | 16.48 | 12.38 | 3 | 44859 | 0 | 29529665 |
Atypical mycobacterial lymphadenitis | 16.48 | 12.38 | 3 | 44859 | 0 | 29529665 |
Gonadal dysgenesis | 16.48 | 12.38 | 3 | 44859 | 0 | 29529665 |
Life expectancy shortened | 16.43 | 12.38 | 5 | 44857 | 41 | 29529624 |
Polyneuropathy chronic | 16.43 | 12.38 | 5 | 44857 | 41 | 29529624 |
Melaena | 16.26 | 12.38 | 14 | 44848 | 31162 | 29498503 |
Optic nerve cupping | 16.22 | 12.38 | 5 | 44857 | 43 | 29529622 |
Hepatitis viral | 16.21 | 12.38 | 10 | 44852 | 509 | 29529156 |
Endocardial fibroelastosis | 16.20 | 12.38 | 4 | 44858 | 13 | 29529652 |
Anaphylactic reaction | 16.15 | 12.38 | 11 | 44851 | 27562 | 29502103 |
Speech disorder developmental | 16.00 | 12.38 | 17 | 44845 | 1890 | 29527775 |
Acute on chronic liver failure | 15.93 | 12.38 | 6 | 44856 | 99 | 29529566 |
Neutrophil count decreased | 15.85 | 12.38 | 26 | 44836 | 43541 | 29486124 |
Dysmorphism | 15.83 | 12.38 | 21 | 44841 | 2950 | 29526715 |
Optic disc haemorrhage | 15.83 | 12.38 | 5 | 44857 | 47 | 29529618 |
Anaemia megaloblastic | 15.80 | 12.38 | 7 | 44855 | 178 | 29529487 |
Depressive symptom | 15.65 | 12.38 | 16 | 44846 | 1701 | 29527964 |
Back pain | 15.65 | 12.38 | 91 | 44771 | 102193 | 29427472 |
Hepatitis B e antigen positive | 15.64 | 12.38 | 5 | 44857 | 49 | 29529616 |
Protrusion tongue | 15.62 | 12.38 | 7 | 44855 | 183 | 29529482 |
Non-Hodgkin's lymphoma | 15.59 | 12.38 | 15 | 44847 | 1482 | 29528183 |
COVID-19 | 15.58 | 12.38 | 19 | 44843 | 35995 | 29493670 |
Anal cancer stage 0 | 15.56 | 12.38 | 4 | 44858 | 16 | 29529649 |
Respiratory arrest | 15.54 | 12.38 | 10 | 44852 | 25823 | 29503842 |
Psychiatric decompensation | 15.53 | 12.38 | 15 | 44847 | 1489 | 29528176 |
Optic neuropathy | 15.51 | 12.38 | 16 | 44846 | 1719 | 29527946 |
Transient ischaemic attack | 15.43 | 12.38 | 8 | 44854 | 23262 | 29506403 |
Macrocephaly | 15.41 | 12.38 | 9 | 44853 | 414 | 29529251 |
Infection | 15.39 | 12.38 | 62 | 44800 | 76689 | 29452976 |
Micrognathia | 15.19 | 12.38 | 8 | 44854 | 300 | 29529365 |
Clostridium difficile infection | 15.19 | 12.38 | 3 | 44859 | 16138 | 29513527 |
Ear malformation | 15.17 | 12.38 | 8 | 44854 | 301 | 29529364 |
Aggression | 15.11 | 12.38 | 19 | 44843 | 35522 | 29494143 |
Sepsis | 15.08 | 12.38 | 141 | 44721 | 142541 | 29387124 |
Amylase increased | 15.06 | 12.38 | 28 | 44834 | 5252 | 29524413 |
Glomerulonephritis proliferative | 15.04 | 12.38 | 7 | 44855 | 200 | 29529465 |
Sickle cell anaemia | 15.04 | 12.38 | 7 | 44855 | 200 | 29529465 |
Dyspnoea exertional | 15.01 | 12.38 | 20 | 44842 | 36470 | 29493195 |
Renal glycosuria | 15.00 | 12.38 | 4 | 44858 | 19 | 29529646 |
Full blood count decreased | 14.99 | 12.38 | 3 | 44859 | 15989 | 29513676 |
Sinusitis | 14.99 | 12.38 | 18 | 44844 | 34332 | 29495333 |
Musculoskeletal toxicity | 14.96 | 12.38 | 6 | 44856 | 118 | 29529547 |
Adrenogenital syndrome | 14.96 | 12.38 | 5 | 44857 | 57 | 29529608 |
Portal fibrosis | 14.88 | 12.38 | 8 | 44854 | 313 | 29529352 |
Rhinorrhoea | 14.87 | 12.38 | 7 | 44855 | 21512 | 29508153 |
Drug intolerance | 14.85 | 12.38 | 32 | 44830 | 48347 | 29481318 |
Urinary retention | 14.69 | 12.38 | 16 | 44846 | 31882 | 29497783 |
Liver tenderness | 14.69 | 12.38 | 6 | 44856 | 124 | 29529541 |
Subacute sclerosing panencephalitis | 14.67 | 12.38 | 4 | 44858 | 21 | 29529644 |
Creatinine renal clearance abnormal | 14.61 | 12.38 | 7 | 44855 | 214 | 29529451 |
Anogenital dysplasia | 14.60 | 12.38 | 6 | 44856 | 126 | 29529539 |
Myopia | 14.59 | 12.38 | 12 | 44850 | 964 | 29528701 |
Overdose | 14.46 | 12.38 | 67 | 44795 | 79752 | 29449913 |
Hepatitis B DNA decreased | 14.40 | 12.38 | 3 | 44859 | 3 | 29529662 |
Tracheal fistula repair | 14.40 | 12.38 | 3 | 44859 | 3 | 29529662 |
Retroviral infection | 14.40 | 12.38 | 3 | 44859 | 3 | 29529662 |
Osteocalcin increased | 14.40 | 12.38 | 3 | 44859 | 3 | 29529662 |
Hyperphosphaturia | 14.37 | 12.38 | 5 | 44857 | 65 | 29529600 |
Fluid retention | 14.34 | 12.38 | 9 | 44853 | 23551 | 29506114 |
Plasmablastic lymphoma | 14.31 | 12.38 | 7 | 44855 | 224 | 29529441 |
Nervous system disorder | 14.25 | 12.38 | 47 | 44815 | 12627 | 29517038 |
Central pain syndrome | 14.23 | 12.38 | 5 | 44857 | 67 | 29529598 |
Congenital tuberculosis | 14.22 | 12.38 | 4 | 44858 | 24 | 29529641 |
Basal cell carcinoma | 14.22 | 12.38 | 4 | 44858 | 16906 | 29512759 |
Erythema elevatum diutinum | 14.08 | 12.38 | 4 | 44858 | 25 | 29529640 |
Pancytopenia | 14.01 | 12.38 | 190 | 44672 | 82978 | 29446687 |
Red blood cell schistocytes present | 14.00 | 12.38 | 7 | 44855 | 235 | 29529430 |
Erythema | 13.98 | 12.38 | 63 | 44799 | 75543 | 29454122 |
Scleral discolouration | 13.95 | 12.38 | 7 | 44855 | 237 | 29529428 |
Osteodystrophy | 13.94 | 12.38 | 3 | 44859 | 4 | 29529661 |
Late developer | 13.94 | 12.38 | 3 | 44859 | 4 | 29529661 |
Nephropathy | 13.89 | 12.38 | 27 | 44835 | 5236 | 29524429 |
Neck deformity | 13.84 | 12.38 | 5 | 44857 | 73 | 29529592 |
Portal hypertensive gastropathy | 13.78 | 12.38 | 9 | 44853 | 506 | 29529159 |
Glucose tolerance impaired | 13.75 | 12.38 | 19 | 44843 | 2775 | 29526890 |
Developmental delay | 13.73 | 12.38 | 18 | 44844 | 2500 | 29527165 |
Full blood count abnormal | 13.70 | 12.38 | 3 | 44859 | 15010 | 29514655 |
Cardiogenic shock | 13.64 | 12.38 | 6 | 44856 | 19184 | 29510481 |
Tracheal stenosis | 13.38 | 12.38 | 6 | 44856 | 157 | 29529508 |
Spermatozoa progressive motility abnormal | 13.34 | 12.38 | 4 | 44858 | 31 | 29529634 |
Graft infection | 13.33 | 12.38 | 8 | 44854 | 387 | 29529278 |
Sleep apnoea syndrome | 13.33 | 12.38 | 5 | 44857 | 17594 | 29512071 |
Molluscum contagiosum | 13.30 | 12.38 | 7 | 44855 | 262 | 29529403 |
Nasal congestion | 13.27 | 12.38 | 6 | 44856 | 18873 | 29510792 |
Hypoglycaemia | 13.22 | 12.38 | 34 | 44828 | 48312 | 29481353 |
Ocular icterus | 13.19 | 12.38 | 18 | 44844 | 2597 | 29527068 |
Hereditary optic atrophy | 13.19 | 12.38 | 3 | 44859 | 6 | 29529659 |
Benign hepatic neoplasm | 13.19 | 12.38 | 3 | 44859 | 6 | 29529659 |
Congenital pigmentation disorder | 13.19 | 12.38 | 3 | 44859 | 6 | 29529659 |
Intentional overdose | 13.10 | 12.38 | 24 | 44838 | 38504 | 29491161 |
Genital herpes | 13.08 | 12.38 | 9 | 44853 | 552 | 29529113 |
Memory impairment | 13.05 | 12.38 | 22 | 44840 | 36448 | 29493217 |
Musculoskeletal stiffness | 13.03 | 12.38 | 23 | 44839 | 37435 | 29492230 |
Hepatic steatosis | 13.03 | 12.38 | 51 | 44811 | 14895 | 29514770 |
C-reactive protein increased | 12.99 | 12.38 | 30 | 44832 | 44233 | 29485432 |
Mobility decreased | 12.94 | 12.38 | 12 | 44850 | 25768 | 29503897 |
Diabetes mellitus | 12.92 | 12.38 | 104 | 44758 | 39727 | 29489938 |
Headache | 12.92 | 12.38 | 186 | 44676 | 173821 | 29355844 |
Congenital hydrocephalus | 12.88 | 12.38 | 5 | 44857 | 90 | 29529575 |
Birth trauma | 12.88 | 12.38 | 3 | 44859 | 7 | 29529658 |
Total lung capacity decreased | 12.86 | 12.38 | 9 | 44853 | 567 | 29529098 |
Body fat disorder | 12.82 | 12.38 | 4 | 44858 | 36 | 29529629 |
Ergot poisoning | 12.82 | 12.38 | 4 | 44858 | 36 | 29529629 |
Vision blurred | 12.81 | 12.38 | 26 | 44836 | 40150 | 29489515 |
Stomatitis | 12.72 | 12.38 | 23 | 44839 | 37090 | 29492575 |
Tracheo-oesophageal fistula | 12.71 | 12.38 | 8 | 44854 | 422 | 29529243 |
Skin candida | 12.67 | 12.38 | 8 | 44854 | 424 | 29529241 |
HIV associated nephropathy | 12.63 | 12.38 | 7 | 44855 | 291 | 29529374 |
CD4 lymphocytes abnormal | 12.62 | 12.38 | 4 | 44858 | 38 | 29529627 |
Pain in extremity | 12.60 | 12.38 | 107 | 44755 | 110326 | 29419339 |
Congenital anaemia | 12.59 | 12.38 | 3 | 44859 | 8 | 29529657 |
Extensor plantar response | 12.59 | 12.38 | 9 | 44853 | 587 | 29529078 |
Diarrhoea | 12.53 | 12.38 | 397 | 44465 | 332301 | 29197364 |
Congenital hearing disorder | 12.53 | 12.38 | 5 | 44857 | 97 | 29529568 |
Asthma | 12.50 | 12.38 | 20 | 44842 | 33829 | 29495836 |
Blood lactate dehydrogenase increased | 12.49 | 12.38 | 60 | 44802 | 19149 | 29510516 |
Gout | 12.48 | 12.38 | 5 | 44857 | 16906 | 29512759 |
Viral infection | 12.48 | 12.38 | 50 | 44812 | 14760 | 29514905 |
Lymphoma | 12.47 | 12.38 | 38 | 44824 | 9790 | 29519875 |
Choroiditis | 12.43 | 12.38 | 11 | 44851 | 977 | 29528688 |
Blood pressure systolic increased | 12.40 | 12.38 | 5 | 44857 | 16840 | 29512825 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Immune reconstitution inflammatory syndrome | 2252.33 | 12.57 | 706 | 55793 | 11764 | 64430469 |
Viral mutation identified | 2141.85 | 12.57 | 513 | 55986 | 2833 | 64439400 |
Virologic failure | 2108.47 | 12.57 | 510 | 55989 | 2956 | 64439277 |
Drug resistance | 1617.16 | 12.57 | 730 | 55769 | 34372 | 64407861 |
Pathogen resistance | 1607.97 | 12.57 | 548 | 55951 | 11995 | 64430238 |
Exposure during pregnancy | 1112.51 | 12.57 | 746 | 55753 | 76929 | 64365304 |
Lipodystrophy acquired | 1023.93 | 12.57 | 297 | 56202 | 3730 | 64438503 |
Abortion spontaneous | 961.70 | 12.57 | 460 | 56039 | 24683 | 64417550 |
Stillbirth | 788.24 | 12.57 | 237 | 56262 | 3396 | 64438837 |
Blood HIV RNA increased | 738.80 | 12.57 | 186 | 56313 | 1298 | 64440935 |
Hepatitis B | 713.63 | 12.57 | 265 | 56234 | 7480 | 64434753 |
Mitochondrial toxicity | 636.87 | 12.57 | 188 | 56311 | 2518 | 64439715 |
Hepatitis B reactivation | 573.37 | 12.57 | 200 | 56299 | 4689 | 64437544 |
Abortion induced | 539.16 | 12.57 | 205 | 56294 | 6183 | 64436050 |
Drug interaction | 484.82 | 12.57 | 1013 | 55486 | 361070 | 64081163 |
Fanconi syndrome acquired | 482.64 | 12.57 | 148 | 56351 | 2273 | 64439960 |
Hepatitis B DNA increased | 473.10 | 12.57 | 110 | 56389 | 520 | 64441713 |
Acquired gene mutation | 471.83 | 12.57 | 139 | 56360 | 1847 | 64440386 |
Osteomalacia | 409.28 | 12.57 | 115 | 56384 | 1276 | 64440957 |
Eyelid ptosis | 286.12 | 12.57 | 148 | 56351 | 9377 | 64432856 |
Viral load increased | 281.09 | 12.57 | 99 | 56400 | 2388 | 64439845 |
Hypophosphataemia | 268.71 | 12.57 | 165 | 56334 | 14555 | 64427678 |
Foetal exposure during pregnancy | 267.47 | 12.57 | 112 | 56387 | 4364 | 64437869 |
Progressive external ophthalmoplegia | 263.98 | 12.57 | 81 | 56418 | 1246 | 64440987 |
Hepatic failure | 258.01 | 12.57 | 279 | 56220 | 55115 | 64387118 |
Lipoatrophy | 248.80 | 12.57 | 66 | 56433 | 579 | 64441654 |
CD4 lymphocytes decreased | 245.27 | 12.57 | 89 | 56410 | 2346 | 64439887 |
Fanconi syndrome | 242.95 | 12.57 | 89 | 56410 | 2412 | 64439821 |
Depression | 242.24 | 12.57 | 511 | 55988 | 182780 | 64259453 |
Pregnancy | 223.15 | 12.57 | 168 | 56331 | 20697 | 64421536 |
Treatment noncompliance | 216.61 | 12.57 | 227 | 56272 | 43255 | 64398978 |
Blood bilirubin increased | 209.14 | 12.57 | 255 | 56244 | 57298 | 64384935 |
Nephropathy toxic | 207.51 | 12.57 | 150 | 56349 | 17364 | 64424869 |
Live birth | 197.91 | 12.57 | 123 | 56376 | 11081 | 64431152 |
Meningitis cryptococcal | 192.31 | 12.57 | 79 | 56420 | 2930 | 64439303 |
Portal hypertension | 187.84 | 12.57 | 97 | 56402 | 6122 | 64436111 |
CSF HIV escape syndrome | 183.14 | 12.57 | 45 | 56454 | 280 | 64441953 |
Hepatic fibrosis | 174.64 | 12.57 | 89 | 56410 | 5463 | 64436770 |
Hepatotoxicity | 173.43 | 12.57 | 194 | 56305 | 39768 | 64402465 |
Fall | 172.17 | 12.57 | 75 | 56424 | 416751 | 64025482 |
Renal tubular disorder | 171.15 | 12.57 | 90 | 56409 | 5897 | 64436336 |
Multiple-drug resistance | 169.72 | 12.57 | 92 | 56407 | 6410 | 64435823 |
Pain | 157.53 | 12.57 | 152 | 56347 | 553359 | 63888874 |
Hypertriglyceridaemia | 156.12 | 12.57 | 106 | 56393 | 11099 | 64431134 |
Kaposi's sarcoma | 154.44 | 12.57 | 47 | 56452 | 702 | 64441531 |
Caesarean section | 153.16 | 12.57 | 105 | 56394 | 11169 | 64431064 |
Alanine aminotransferase increased | 152.47 | 12.57 | 360 | 56139 | 138671 | 64303562 |
Diplopia | 151.98 | 12.57 | 150 | 56349 | 26615 | 64415618 |
Completed suicide | 148.57 | 12.57 | 13 | 56486 | 224401 | 64217832 |
Jaundice | 147.87 | 12.57 | 197 | 56302 | 48315 | 64393918 |
Proteinuria | 147.54 | 12.57 | 150 | 56349 | 27573 | 64414660 |
Pulmonary tuberculosis | 147.18 | 12.57 | 87 | 56412 | 7157 | 64435076 |
Peripheral swelling | 144.40 | 12.57 | 10 | 56489 | 209143 | 64233090 |
Mitochondrial cytopathy | 136.42 | 12.57 | 37 | 56462 | 356 | 64441877 |
Maternal exposure during pregnancy | 135.48 | 12.57 | 275 | 56224 | 95609 | 64346624 |
Maternal drugs affecting foetus | 133.11 | 12.57 | 51 | 56448 | 1569 | 64440664 |
Retinal toxicity | 131.67 | 12.57 | 48 | 56451 | 1282 | 64440951 |
Genotype drug resistance test positive | 131.25 | 12.57 | 45 | 56454 | 999 | 64441234 |
Joint swelling | 131.02 | 12.57 | 17 | 56482 | 215365 | 64226868 |
Glycosuria | 131.01 | 12.57 | 54 | 56445 | 2020 | 64440213 |
Hypomania | 128.40 | 12.57 | 73 | 56426 | 5581 | 64436652 |
Lymphadenopathy | 126.33 | 12.57 | 179 | 56320 | 46507 | 64395726 |
Hyperbilirubinaemia | 126.30 | 12.57 | 122 | 56377 | 21083 | 64421150 |
Off label use | 125.61 | 12.57 | 227 | 56272 | 632579 | 63809654 |
Renal tubular dysfunction | 123.58 | 12.57 | 39 | 56460 | 661 | 64441572 |
Foetal death | 122.53 | 12.57 | 72 | 56427 | 5858 | 64436375 |
Tuberculosis | 117.73 | 12.57 | 95 | 56404 | 12943 | 64429290 |
Hepatitis C | 114.02 | 12.57 | 87 | 56412 | 10928 | 64431305 |
Lactic acidosis | 114.00 | 12.57 | 198 | 56301 | 61212 | 64381021 |
Hyperlactacidaemia | 113.94 | 12.57 | 64 | 56435 | 4780 | 64437453 |
Rheumatoid arthritis | 112.96 | 12.57 | 8 | 56491 | 164286 | 64277947 |
Mycobacterium avium complex infection | 111.97 | 12.57 | 59 | 56440 | 3881 | 64438352 |
Aspartate aminotransferase increased | 111.07 | 12.57 | 291 | 56208 | 119497 | 64322736 |
Fatigue | 110.89 | 12.57 | 315 | 56184 | 748415 | 63693818 |
Gene mutation | 110.82 | 12.57 | 48 | 56451 | 2034 | 64440199 |
Product dose omission issue | 110.10 | 12.57 | 19 | 56480 | 194728 | 64247505 |
Nasopharyngitis | 108.95 | 12.57 | 20 | 56479 | 196053 | 64246180 |
Hepatic cirrhosis | 107.85 | 12.57 | 124 | 56375 | 26174 | 64416059 |
Infusion related reaction | 107.55 | 12.57 | 10 | 56489 | 164457 | 64277776 |
HIV-associated neurocognitive disorder | 105.29 | 12.57 | 29 | 56470 | 297 | 64441936 |
Jaundice cholestatic | 104.39 | 12.57 | 75 | 56424 | 8595 | 64433638 |
Hepatomegaly | 98.42 | 12.57 | 96 | 56403 | 16786 | 64425447 |
Immune reconstitution inflammatory syndrome associated tuberculosis | 95.94 | 12.57 | 33 | 56466 | 740 | 64441493 |
Hypouricaemia | 94.34 | 12.57 | 28 | 56471 | 382 | 64441851 |
Dyslipidaemia | 93.48 | 12.57 | 72 | 56427 | 9170 | 64433063 |
Drug-induced liver injury | 92.87 | 12.57 | 157 | 56342 | 47486 | 64394747 |
Premature rupture of membranes | 92.25 | 12.57 | 51 | 56448 | 3693 | 64438540 |
Anaemia | 92.17 | 12.57 | 607 | 55892 | 378073 | 64064160 |
Schizophrenia | 91.69 | 12.57 | 77 | 56422 | 11091 | 64431142 |
Pinealoblastoma | 89.26 | 12.57 | 19 | 56480 | 54 | 64442179 |
Premature labour | 87.38 | 12.57 | 64 | 56435 | 7556 | 64434677 |
Hepatic function abnormal | 86.73 | 12.57 | 181 | 56318 | 64132 | 64378101 |
Dyspnoea | 85.90 | 12.57 | 332 | 56167 | 718342 | 63723891 |
Arthropathy | 85.79 | 12.57 | 5 | 56494 | 120962 | 64321271 |
Urine phosphorus increased | 85.51 | 12.57 | 19 | 56480 | 70 | 64442163 |
Osteoporosis | 85.12 | 12.57 | 141 | 56358 | 41939 | 64400294 |
Osteonecrosis | 85.02 | 12.57 | 114 | 56385 | 28115 | 64414118 |
Hepatocellular carcinoma | 83.98 | 12.57 | 65 | 56434 | 8338 | 64433895 |
Psychotic disorder | 81.14 | 12.57 | 124 | 56375 | 34454 | 64407779 |
Hepatitis | 80.74 | 12.57 | 144 | 56355 | 45438 | 64396795 |
Renal impairment | 80.68 | 12.57 | 281 | 56218 | 134736 | 64307497 |
Pre-eclampsia | 79.86 | 12.57 | 56 | 56443 | 6175 | 64436058 |
Stevens-Johnson syndrome | 79.22 | 12.57 | 122 | 56377 | 34127 | 64408106 |
Blood alkaline phosphatase increased | 78.95 | 12.57 | 161 | 56338 | 56118 | 64386115 |
Constipation | 78.81 | 12.57 | 52 | 56447 | 229285 | 64212948 |
Fat tissue increased | 78.19 | 12.57 | 29 | 56470 | 814 | 64441419 |
Gamma-glutamyltransferase increased | 75.56 | 12.57 | 145 | 56354 | 48365 | 64393868 |
Injection site pain | 74.93 | 12.57 | 6 | 56493 | 111402 | 64330831 |
Blood phosphorus decreased | 74.82 | 12.57 | 52 | 56447 | 5653 | 64436580 |
Synovitis | 73.77 | 12.57 | 3 | 56496 | 99087 | 64343146 |
Abdominal discomfort | 73.25 | 12.57 | 34 | 56465 | 182288 | 64259945 |
Blood bilirubin unconjugated increased | 72.25 | 12.57 | 28 | 56471 | 889 | 64441344 |
Cytomegalovirus chorioretinitis | 72.09 | 12.57 | 48 | 56451 | 4864 | 64437369 |
Blood lactic acid increased | 71.86 | 12.57 | 65 | 56434 | 10336 | 64431897 |
Sinusitis | 70.83 | 12.57 | 20 | 56479 | 145908 | 64296325 |
Hepatosplenomegaly | 70.77 | 12.57 | 49 | 56450 | 5294 | 64436939 |
Retinoblastoma | 68.40 | 12.57 | 16 | 56483 | 78 | 64442155 |
Ergot poisoning | 66.73 | 12.57 | 17 | 56482 | 125 | 64442108 |
Varices oesophageal | 65.50 | 12.57 | 46 | 56453 | 5084 | 64437149 |
Hypotension | 64.88 | 12.57 | 149 | 56350 | 380825 | 64061408 |
Drug ineffective | 64.86 | 12.57 | 451 | 56048 | 839796 | 63602437 |
Normal newborn | 64.00 | 12.57 | 47 | 56452 | 5570 | 64436663 |
Blood pressure increased | 63.62 | 12.57 | 36 | 56463 | 172516 | 64269717 |
Cachexia | 62.50 | 12.57 | 57 | 56442 | 9160 | 64433073 |
Contusion | 62.48 | 12.57 | 12 | 56487 | 113953 | 64328280 |
Ophthalmoplegia | 61.66 | 12.57 | 35 | 56464 | 2667 | 64439566 |
Cryptococcosis | 61.03 | 12.57 | 35 | 56464 | 2720 | 64439513 |
Hepatic encephalopathy | 60.29 | 12.57 | 83 | 56416 | 20983 | 64421250 |
Calculus urinary | 59.07 | 12.57 | 30 | 56469 | 1827 | 64440406 |
Acquired immunodeficiency syndrome | 59.05 | 12.57 | 17 | 56482 | 207 | 64442026 |
Drug intolerance | 58.87 | 12.57 | 47 | 56452 | 187945 | 64254288 |
Ascites | 58.83 | 12.57 | 152 | 56347 | 61849 | 64380384 |
Lipohypertrophy | 58.22 | 12.57 | 23 | 56476 | 769 | 64441464 |
Premature baby | 57.98 | 12.57 | 36 | 56463 | 3236 | 64438997 |
Pneumocystis jirovecii pneumonia | 57.78 | 12.57 | 94 | 56405 | 27540 | 64414693 |
Hyperlipidaemia | 57.62 | 12.57 | 85 | 56414 | 22891 | 64419342 |
Therapeutic product effect decreased | 57.50 | 12.57 | 15 | 56484 | 115336 | 64326897 |
HIV infection | 56.75 | 12.57 | 24 | 56475 | 958 | 64441275 |
Feeling abnormal | 56.69 | 12.57 | 23 | 56476 | 133579 | 64308654 |
Death | 56.24 | 12.57 | 225 | 56274 | 482480 | 63959753 |
Systemic lupus erythematosus | 55.66 | 12.57 | 3 | 56496 | 77609 | 64364624 |
Amniotic cavity infection | 55.23 | 12.57 | 22 | 56477 | 752 | 64441481 |
Blood triglycerides increased | 55.00 | 12.57 | 75 | 56424 | 18791 | 64423442 |
Alopecia | 54.99 | 12.57 | 39 | 56460 | 165651 | 64276582 |
Splenomegaly | 54.79 | 12.57 | 73 | 56426 | 17888 | 64424345 |
Drug abuse | 54.23 | 12.57 | 24 | 56475 | 132350 | 64309883 |
Cushing's syndrome | 54.16 | 12.57 | 23 | 56476 | 928 | 64441305 |
Lymph node tuberculosis | 54.04 | 12.57 | 23 | 56476 | 933 | 64441300 |
Hepatitis A | 53.90 | 12.57 | 22 | 56477 | 802 | 64441431 |
Cerebral toxoplasmosis | 53.76 | 12.57 | 28 | 56471 | 1798 | 64440435 |
Facial wasting | 53.31 | 12.57 | 13 | 56486 | 78 | 64442155 |
Cholelithiasis | 53.28 | 12.57 | 121 | 56378 | 45385 | 64396848 |
Progressive multifocal leukoencephalopathy | 50.92 | 12.57 | 71 | 56428 | 18161 | 64424072 |
Renal tubular acidosis | 50.83 | 12.57 | 32 | 56467 | 2947 | 64439286 |
Transaminases increased | 50.47 | 12.57 | 117 | 56382 | 44477 | 64397756 |
Urinary tract infection | 50.45 | 12.57 | 78 | 56421 | 231518 | 64210715 |
Swelling | 50.23 | 12.57 | 40 | 56459 | 160178 | 64282055 |
Injection site erythema | 49.96 | 12.57 | 3 | 56496 | 70797 | 64371436 |
Premature delivery | 49.86 | 12.57 | 71 | 56428 | 18518 | 64423715 |
Hypophosphataemic osteomalacia | 49.85 | 12.57 | 16 | 56483 | 287 | 64441946 |
Mitochondrial DNA deletion | 49.78 | 12.57 | 9 | 56490 | 6 | 64442227 |
Nodular regenerative hyperplasia | 49.41 | 12.57 | 21 | 56478 | 849 | 64441384 |
Wound | 49.05 | 12.57 | 5 | 56494 | 76472 | 64365761 |
Nephrolithiasis | 48.77 | 12.57 | 114 | 56385 | 43569 | 64398664 |
Pyrexia | 47.87 | 12.57 | 720 | 55779 | 557924 | 63884309 |
Alpha 1 foetoprotein abnormal | 47.65 | 12.57 | 11 | 56488 | 50 | 64442183 |
Oesophageal varices haemorrhage | 47.41 | 12.57 | 33 | 56466 | 3596 | 64438637 |
Oligohydramnios | 46.99 | 12.57 | 31 | 56468 | 3093 | 64439140 |
Malignant neoplasm progression | 46.97 | 12.57 | 20 | 56479 | 112851 | 64329382 |
Hepatic cancer | 46.52 | 12.57 | 44 | 56455 | 7404 | 64434829 |
Blood creatinine increased | 46.15 | 12.57 | 238 | 56261 | 135544 | 64306689 |
Ectopic pregnancy | 46.09 | 12.57 | 24 | 56475 | 1540 | 64440693 |
Oesophageal candidiasis | 45.62 | 12.57 | 45 | 56454 | 7972 | 64434261 |
Arthritis | 45.57 | 12.57 | 9 | 56490 | 83805 | 64358428 |
Arthralgia | 45.48 | 12.57 | 216 | 56283 | 442044 | 64000189 |
Rickets | 45.25 | 12.57 | 11 | 56488 | 65 | 64442168 |
Aminoaciduria | 45.17 | 12.57 | 14 | 56485 | 223 | 64442010 |
Hepatitis B surface antigen positive | 44.73 | 12.57 | 13 | 56486 | 164 | 64442069 |
Pancreatitis | 44.57 | 12.57 | 134 | 56365 | 59473 | 64382760 |
Meningitis tuberculous | 44.48 | 12.57 | 21 | 56478 | 1090 | 64441143 |
Weight increased | 44.44 | 12.57 | 74 | 56425 | 213274 | 64228959 |
Basedow's disease | 44.21 | 12.57 | 14 | 56485 | 240 | 64441993 |
HIV viraemia | 44.15 | 12.57 | 11 | 56488 | 73 | 64442160 |
Premature separation of placenta | 43.90 | 12.57 | 21 | 56478 | 1123 | 64441110 |
Toxicity to various agents | 43.85 | 12.57 | 167 | 56332 | 363346 | 64078887 |
Loss of personal independence in daily activities | 43.42 | 12.57 | 151 | 56348 | 72303 | 64369930 |
Wheezing | 43.08 | 12.57 | 9 | 56490 | 80570 | 64361663 |
Placental insufficiency | 43.06 | 12.57 | 20 | 56479 | 1000 | 64441233 |
Atrial fibrillation | 42.91 | 12.57 | 52 | 56447 | 171037 | 64271196 |
Placental disorder | 42.87 | 12.57 | 19 | 56480 | 851 | 64441382 |
Pain in extremity | 42.83 | 12.57 | 130 | 56369 | 302955 | 64139278 |
CD4 lymphocytes increased | 42.82 | 12.57 | 14 | 56485 | 267 | 64441966 |
Renal failure | 42.71 | 12.57 | 289 | 56210 | 181399 | 64260834 |
Influenza | 42.56 | 12.57 | 20 | 56479 | 106511 | 64335722 |
Rash maculo-papular | 42.27 | 12.57 | 113 | 56386 | 46913 | 64395320 |
Ocular icterus | 41.54 | 12.57 | 35 | 56464 | 5063 | 64437170 |
Umbilical cord abnormality | 41.18 | 12.57 | 12 | 56487 | 153 | 64442080 |
Product use issue | 40.33 | 12.57 | 44 | 56455 | 151671 | 64290562 |
Headache | 40.30 | 12.57 | 285 | 56214 | 529182 | 63913051 |
Acquired aminoaciduria | 40.25 | 12.57 | 8 | 56491 | 14 | 64442219 |
Hepatitis B virus test | 39.79 | 12.57 | 7 | 56492 | 3 | 64442230 |
Anaemia macrocytic | 39.60 | 12.57 | 32 | 56467 | 4366 | 64437867 |
Hepatitis cholestatic | 39.55 | 12.57 | 51 | 56448 | 12104 | 64430129 |
Mycobacterium avium complex immune restoration disease | 38.92 | 12.57 | 8 | 56491 | 18 | 64442215 |
Malaria | 38.86 | 12.57 | 14 | 56485 | 361 | 64441872 |
Oxygen saturation decreased | 38.58 | 12.57 | 23 | 56476 | 107153 | 64335080 |
Granulomatous rosacea | 38.38 | 12.57 | 12 | 56487 | 197 | 64442036 |
Oropharyngeal pain | 38.18 | 12.57 | 15 | 56484 | 88852 | 64353381 |
Hepatic cytolysis | 38.18 | 12.57 | 54 | 56445 | 13995 | 64428238 |
Urine calcium increased | 37.87 | 12.57 | 10 | 56489 | 86 | 64442147 |
Inappropriate schedule of product administration | 37.37 | 12.57 | 17 | 56482 | 92269 | 64349964 |
Pruritus | 37.35 | 12.57 | 144 | 56355 | 312256 | 64129977 |
Optic nerve neoplasm | 37.26 | 12.57 | 8 | 56491 | 24 | 64442209 |
Tuberculoma of central nervous system | 36.95 | 12.57 | 15 | 56484 | 539 | 64441694 |
Intentional product misuse | 36.79 | 12.57 | 9 | 56490 | 72286 | 64369947 |
Opportunistic infection | 36.64 | 12.57 | 25 | 56474 | 2637 | 64439596 |
Withdrawal hepatitis | 36.25 | 12.57 | 6 | 56493 | 0 | 64442233 |
Mitochondrial DNA depletion | 36.25 | 12.57 | 6 | 56493 | 0 | 64442233 |
Impaired healing | 36.19 | 12.57 | 5 | 56494 | 60468 | 64381765 |
Stomatitis | 36.09 | 12.57 | 26 | 56473 | 109579 | 64332654 |
Gynaecomastia | 34.67 | 12.57 | 34 | 56465 | 5982 | 64436251 |
Mitochondrial myopathy | 34.56 | 12.57 | 12 | 56487 | 277 | 64441956 |
Oral candidiasis | 34.45 | 12.57 | 68 | 56431 | 23144 | 64419089 |
Drug hypersensitivity | 34.30 | 12.57 | 101 | 56398 | 237714 | 64204519 |
Heart rate decreased | 34.30 | 12.57 | 4 | 56495 | 55063 | 64387170 |
Mycobacterial infection | 34.04 | 12.57 | 25 | 56474 | 2963 | 64439270 |
Dizziness | 33.96 | 12.57 | 229 | 56270 | 429934 | 64012299 |
Hepatitis B DNA assay positive | 33.92 | 12.57 | 9 | 56490 | 79 | 64442154 |
Pancytopenia | 33.69 | 12.57 | 228 | 56271 | 143081 | 64299152 |
Acute hepatitis C | 33.68 | 12.57 | 11 | 56488 | 209 | 64442024 |
Nasal congestion | 33.29 | 12.57 | 6 | 56493 | 59652 | 64382581 |
Muscle spasms | 33.14 | 12.57 | 45 | 56454 | 140978 | 64301255 |
Hypercholesterolaemia | 33.10 | 12.57 | 53 | 56446 | 15320 | 64426913 |
Lower respiratory tract infection | 33.08 | 12.57 | 21 | 56478 | 94593 | 64347640 |
Anxiety | 33.04 | 12.57 | 81 | 56418 | 202568 | 64239665 |
Hyperphosphaturia | 32.78 | 12.57 | 9 | 56490 | 91 | 64442142 |
Malaise | 32.76 | 12.57 | 208 | 56291 | 396039 | 64046194 |
Psoriasis | 32.67 | 12.57 | 11 | 56488 | 71692 | 64370541 |
HIV test positive | 32.43 | 12.57 | 9 | 56490 | 95 | 64442138 |
Viraemia | 32.19 | 12.57 | 22 | 56477 | 2327 | 64439906 |
Treatment failure | 31.86 | 12.57 | 193 | 56306 | 116623 | 64325610 |
Pregnancy on contraceptive | 31.82 | 12.57 | 15 | 56484 | 776 | 64441457 |
Bronchitis | 31.81 | 12.57 | 29 | 56470 | 108714 | 64333519 |
Liver disorder | 31.79 | 12.57 | 111 | 56388 | 53240 | 64388993 |
Disseminated tuberculosis | 31.72 | 12.57 | 26 | 56473 | 3619 | 64438614 |
Toxoplasmosis | 31.40 | 12.57 | 22 | 56477 | 2422 | 64439811 |
Back pain | 31.40 | 12.57 | 113 | 56386 | 250058 | 64192175 |
Diabetes mellitus | 31.09 | 12.57 | 128 | 56371 | 66346 | 64375887 |
Strongyloidiasis | 31.09 | 12.57 | 24 | 56475 | 3066 | 64439167 |
Blood phosphorus abnormal | 30.89 | 12.57 | 11 | 56488 | 274 | 64441959 |
Asthma | 30.82 | 12.57 | 23 | 56476 | 95202 | 64347031 |
Hepatic enzyme increased | 30.70 | 12.57 | 207 | 56292 | 129736 | 64312497 |
Renal glycosuria | 30.66 | 12.57 | 7 | 56492 | 30 | 64442203 |
White matter lesion | 30.65 | 12.57 | 19 | 56480 | 1703 | 64440530 |
Anaphylactic reaction | 30.48 | 12.57 | 11 | 56488 | 68653 | 64373580 |
Vanishing bile duct syndrome | 30.38 | 12.57 | 17 | 56482 | 1260 | 64440973 |
Bilirubin conjugated increased | 30.36 | 12.57 | 29 | 56470 | 4939 | 64437294 |
Neutropenia neonatal | 30.29 | 12.57 | 7 | 56492 | 32 | 64442201 |
Cardio-respiratory arrest | 30.28 | 12.57 | 25 | 56474 | 98368 | 64343865 |
Benign hydatidiform mole | 30.28 | 12.57 | 8 | 56491 | 69 | 64442164 |
Cerebrovascular accident | 30.26 | 12.57 | 46 | 56453 | 137537 | 64304696 |
Retroviral rebound syndrome | 30.01 | 12.57 | 6 | 56493 | 11 | 64442222 |
Stress | 29.91 | 12.57 | 8 | 56491 | 60526 | 64381707 |
Bone metabolism disorder | 29.89 | 12.57 | 12 | 56487 | 419 | 64441814 |
Hyperphosphatasaemia | 29.68 | 12.57 | 8 | 56491 | 75 | 64442158 |
Bone density decreased | 29.67 | 12.57 | 40 | 56459 | 9912 | 64432321 |
Blood pressure fluctuation | 29.42 | 12.57 | 5 | 56494 | 51866 | 64390367 |
Night blindness | 29.26 | 12.57 | 12 | 56487 | 443 | 64441790 |
Somnolence | 28.99 | 12.57 | 87 | 56412 | 203558 | 64238675 |
AIDS cholangiopathy | 28.74 | 12.57 | 6 | 56493 | 15 | 64442218 |
HIV lipodystrophy | 28.74 | 12.57 | 6 | 56493 | 15 | 64442218 |
Infection | 28.52 | 12.57 | 76 | 56423 | 184804 | 64257429 |
Cardiac failure congestive | 28.39 | 12.57 | 44 | 56455 | 130536 | 64311697 |
Musculoskeletal stiffness | 28.26 | 12.57 | 40 | 56459 | 123166 | 64319067 |
Congenital anomaly | 28.16 | 12.57 | 10 | 56489 | 247 | 64441986 |
Respiratory arrest | 28.15 | 12.57 | 6 | 56493 | 52979 | 64389254 |
Confusional state | 27.71 | 12.57 | 126 | 56373 | 261018 | 64181215 |
Rhinorrhoea | 27.67 | 12.57 | 9 | 56490 | 59960 | 64382273 |
Amoebiasis | 27.38 | 12.57 | 8 | 56491 | 103 | 64442130 |
Psoriatic arthropathy | 27.31 | 12.57 | 3 | 56496 | 43278 | 64398955 |
Tuberculoid leprosy | 27.31 | 12.57 | 8 | 56491 | 104 | 64442129 |
Cardiac arrest | 27.19 | 12.57 | 59 | 56440 | 154005 | 64288228 |
Liver transplant | 27.15 | 12.57 | 25 | 56474 | 4067 | 64438166 |
Thrombosis | 27.10 | 12.57 | 14 | 56485 | 70628 | 64371605 |
Placental infarction | 26.83 | 12.57 | 8 | 56491 | 111 | 64442122 |
Tremor | 26.80 | 12.57 | 56 | 56443 | 148174 | 64294059 |
Flushing | 26.76 | 12.57 | 18 | 56481 | 78630 | 64363603 |
Encephalitis | 26.60 | 12.57 | 43 | 56456 | 12528 | 64429705 |
Hepatic steatosis | 26.35 | 12.57 | 73 | 56426 | 30934 | 64411299 |
Unevaluable event | 26.25 | 12.57 | 6 | 56493 | 50483 | 64391750 |
Migraine | 26.24 | 12.57 | 11 | 56488 | 62666 | 64379567 |
HIV wasting syndrome | 26.23 | 12.57 | 7 | 56492 | 63 | 64442170 |
Diarrhoea | 26.11 | 12.57 | 461 | 56038 | 722243 | 63719990 |
Chronic obstructive pulmonary disease | 25.91 | 12.57 | 15 | 56484 | 71033 | 64371200 |
Chronic kidney disease | 25.89 | 12.57 | 110 | 56389 | 57809 | 64384424 |
Atypical mycobacterial lymphadenitis | 25.83 | 12.57 | 5 | 56494 | 7 | 64442226 |
Beta 2 microglobulin urine increased | 25.78 | 12.57 | 8 | 56491 | 128 | 64442105 |
Blister | 25.63 | 12.57 | 20 | 56479 | 80947 | 64361286 |
Anogenital warts | 25.49 | 12.57 | 13 | 56486 | 799 | 64441434 |
Epistaxis | 25.48 | 12.57 | 29 | 56470 | 98102 | 64344131 |
Borderline leprosy | 25.44 | 12.57 | 5 | 56494 | 8 | 64442225 |
Erythema | 25.16 | 12.57 | 82 | 56417 | 186988 | 64255245 |
Rhabdomyosarcoma | 24.95 | 12.57 | 8 | 56491 | 143 | 64442090 |
Blood uric acid increased | 24.62 | 12.57 | 33 | 56466 | 8130 | 64434103 |
Hospitalisation | 24.55 | 12.57 | 18 | 56481 | 75189 | 64367044 |
Hepatitis D | 24.46 | 12.57 | 6 | 56493 | 37 | 64442196 |
Syncope | 24.16 | 12.57 | 65 | 56434 | 157570 | 64284663 |
Glucose urine present | 24.08 | 12.57 | 16 | 56483 | 1616 | 64440617 |
Intentional overdose | 23.99 | 12.57 | 26 | 56473 | 89918 | 64352315 |
Cellulitis | 23.97 | 12.57 | 28 | 56471 | 93629 | 64348604 |
Metabolic acidosis | 23.83 | 12.57 | 124 | 56375 | 70834 | 64371399 |
Lymphocytic infiltration | 23.75 | 12.57 | 15 | 56484 | 1389 | 64440844 |
Herpes simplex | 23.61 | 12.57 | 37 | 56462 | 10499 | 64431734 |
Cholestatic liver injury | 23.48 | 12.57 | 22 | 56477 | 3657 | 64438576 |
Chronic disease | 23.48 | 12.57 | 7 | 56492 | 97 | 64442136 |
Liver transplant rejection | 23.23 | 12.57 | 20 | 56479 | 2979 | 64439254 |
Urine phosphorus decreased | 23.11 | 12.57 | 6 | 56493 | 48 | 64442185 |
Astrocytoma, low grade | 23.11 | 12.57 | 6 | 56493 | 48 | 64442185 |
Hepatitis fulminant | 23.09 | 12.57 | 28 | 56471 | 6246 | 64435987 |
Parotid gland enlargement | 23.06 | 12.57 | 12 | 56487 | 769 | 64441464 |
Central nervous system lesion | 23.01 | 12.57 | 39 | 56460 | 11810 | 64430423 |
Primary syphilis | 22.81 | 12.57 | 5 | 56494 | 17 | 64442216 |
Bradycardia | 22.80 | 12.57 | 43 | 56456 | 118176 | 64324057 |
Dermatitis exfoliative | 22.71 | 12.57 | 36 | 56463 | 10316 | 64431917 |
Tubulointerstitial nephritis | 22.64 | 12.57 | 69 | 56430 | 30840 | 64411393 |
Fluid retention | 22.58 | 12.57 | 12 | 56487 | 59594 | 64382639 |
Taeniasis | 22.58 | 12.57 | 6 | 56493 | 53 | 64442180 |
Molluscum contagiosum | 22.56 | 12.57 | 10 | 56489 | 448 | 64441785 |
Hepatitis E | 22.55 | 12.57 | 18 | 56481 | 2413 | 64439820 |
Isosporiasis | 22.55 | 12.57 | 7 | 56492 | 112 | 64442121 |
Intracranial pressure increased | 22.23 | 12.57 | 29 | 56470 | 6960 | 64435273 |
Osteoporotic fracture | 21.98 | 12.57 | 21 | 56478 | 3577 | 64438656 |
Burning sensation | 21.97 | 12.57 | 8 | 56491 | 49656 | 64392577 |
Blood bicarbonate decreased | 21.89 | 12.57 | 24 | 56475 | 4805 | 64437428 |
Pericarditis | 21.68 | 12.57 | 14 | 56485 | 62502 | 64379731 |
Viral load decreased | 21.61 | 12.57 | 5 | 56494 | 23 | 64442210 |
Blood creatine phosphokinase increased | 21.54 | 12.57 | 105 | 56394 | 58453 | 64383780 |
Cryoglobulinaemia | 21.52 | 12.57 | 11 | 56488 | 679 | 64441554 |
Erosive duodenitis | 21.32 | 12.57 | 15 | 56484 | 1663 | 64440570 |
Diverticulitis | 21.30 | 12.57 | 4 | 56495 | 38614 | 64403619 |
Placenta praevia | 21.28 | 12.57 | 11 | 56488 | 695 | 64441538 |
Anaemia neonatal | 21.27 | 12.57 | 5 | 56494 | 25 | 64442208 |
Haematoma | 21.23 | 12.57 | 7 | 56492 | 46243 | 64395990 |
Hot flush | 21.22 | 12.57 | 7 | 56492 | 46228 | 64396005 |
Hyperhidrosis | 21.09 | 12.57 | 49 | 56450 | 124871 | 64317362 |
Nephropathy | 20.99 | 12.57 | 31 | 56468 | 8355 | 64433878 |
Anembryonic gestation | 20.76 | 12.57 | 9 | 56490 | 382 | 64441851 |
Gestational diabetes | 20.66 | 12.57 | 25 | 56474 | 5565 | 64436668 |
Swollen tongue | 20.66 | 12.57 | 3 | 56496 | 34951 | 64407282 |
Hyponatraemia | 20.66 | 12.57 | 64 | 56435 | 148275 | 64293958 |
Breech delivery | 20.65 | 12.57 | 5 | 56494 | 29 | 64442204 |
Bulbar palsy | 20.64 | 12.57 | 8 | 56491 | 254 | 64441979 |
Non-Hodgkin's lymphoma | 20.60 | 12.57 | 14 | 56485 | 1467 | 64440766 |
Chest pain | 20.44 | 12.57 | 122 | 56377 | 235858 | 64206375 |
Haematochezia | 20.25 | 12.57 | 17 | 56482 | 66356 | 64375877 |
Retroviral infection | 20.12 | 12.57 | 4 | 56495 | 7 | 64442226 |
Hypoglycaemia | 19.81 | 12.57 | 30 | 56469 | 89862 | 64352371 |
Type III hyperlipidaemia | 19.78 | 12.57 | 4 | 56495 | 8 | 64442225 |
Loss of anatomical alignment after fracture reduction | 19.78 | 12.57 | 4 | 56495 | 8 | 64442225 |
Pneumonia aspiration | 19.58 | 12.57 | 14 | 56485 | 59257 | 64382976 |
HIV associated nephropathy | 19.56 | 12.57 | 8 | 56491 | 293 | 64441940 |
Cough | 19.49 | 12.57 | 170 | 56329 | 301978 | 64140255 |
Memory impairment | 19.47 | 12.57 | 28 | 56471 | 85654 | 64356579 |
Dehydration | 19.34 | 12.57 | 111 | 56388 | 216652 | 64225581 |
Antimitochondrial antibody positive | 19.27 | 12.57 | 6 | 56493 | 97 | 64442136 |
Lymphadenitis | 19.26 | 12.57 | 20 | 56479 | 3765 | 64438468 |
Neuromyopathy | 19.19 | 12.57 | 13 | 56486 | 1355 | 64440878 |
Helicobacter infection | 19.09 | 12.57 | 5 | 56494 | 38357 | 64403876 |
Fibromyalgia | 19.08 | 12.57 | 4 | 56495 | 35727 | 64406506 |
Histoplasmosis disseminated | 18.98 | 12.57 | 15 | 56484 | 1983 | 64440250 |
Ballismus | 18.92 | 12.57 | 7 | 56492 | 195 | 64442038 |
Disseminated Bacillus Calmette-Guerin infection | 18.92 | 12.57 | 7 | 56492 | 195 | 64442038 |
Pneumonia | 18.90 | 12.57 | 361 | 56138 | 559215 | 63883018 |
Urticaria | 18.83 | 12.57 | 66 | 56433 | 147251 | 64294982 |
Discomfort | 18.80 | 12.57 | 26 | 56473 | 80852 | 64361381 |
Hepatitis viral | 18.73 | 12.57 | 11 | 56488 | 894 | 64441339 |
Cystitis | 18.66 | 12.57 | 7 | 56492 | 42668 | 64399565 |
Abortion missed | 18.53 | 12.57 | 12 | 56487 | 1160 | 64441073 |
Portal hypertensive gastropathy | 18.53 | 12.57 | 12 | 56487 | 1160 | 64441073 |
Postpartum haemorrhage | 18.53 | 12.57 | 13 | 56486 | 1434 | 64440799 |
Neck pain | 18.48 | 12.57 | 16 | 56483 | 61517 | 64380716 |
Chest discomfort | 18.45 | 12.57 | 47 | 56452 | 116059 | 64326174 |
Disease progression | 18.43 | 12.57 | 63 | 56436 | 141617 | 64300616 |
Central nervous system immune reconstitution inflammatory response | 18.35 | 12.57 | 5 | 56494 | 49 | 64442184 |
Lip swelling | 18.26 | 12.57 | 3 | 56496 | 31904 | 64410329 |
Optic nerve cupping | 18.17 | 12.57 | 5 | 56494 | 51 | 64442182 |
Blood lactate dehydrogenase increased | 18.15 | 12.57 | 67 | 56432 | 33011 | 64409222 |
AIDS related complex | 18.12 | 12.57 | 3 | 56496 | 0 | 64442233 |
Vertical infection transmission | 18.12 | 12.57 | 3 | 56496 | 0 | 64442233 |
Prenatal screening test abnormal | 18.12 | 12.57 | 3 | 56496 | 0 | 64442233 |
Alpha 1 foetoprotein increased | 18.01 | 12.57 | 10 | 56489 | 730 | 64441503 |
Incorrect dose administered | 18.01 | 12.57 | 16 | 56483 | 60749 | 64381484 |
Oropharyngeal candidiasis | 17.99 | 12.57 | 13 | 56486 | 1502 | 64440731 |
Pubertal failure | 17.95 | 12.57 | 4 | 56495 | 15 | 64442218 |
Erythema elevatum diutinum | 17.95 | 12.57 | 4 | 56495 | 15 | 64442218 |
Trisomy 21 | 17.91 | 12.57 | 5 | 56494 | 54 | 64442179 |
Ultrasound scan abnormal | 17.89 | 12.57 | 7 | 56492 | 228 | 64442005 |
Bacterial pyelonephritis | 17.85 | 12.57 | 9 | 56490 | 540 | 64441693 |
CD4 lymphocytes | 17.74 | 12.57 | 4 | 56495 | 16 | 64442217 |
Product use in unapproved indication | 17.67 | 12.57 | 87 | 56412 | 176531 | 64265702 |
AIDS related complication | 17.67 | 12.57 | 5 | 56494 | 57 | 64442176 |
Amylase increased | 17.66 | 12.57 | 31 | 56468 | 9654 | 64432579 |
Balance disorder | 17.56 | 12.57 | 29 | 56470 | 83897 | 64358336 |
Injury | 17.51 | 12.57 | 14 | 56485 | 55978 | 64386255 |
Clostridium difficile infection | 17.45 | 12.57 | 5 | 56494 | 36158 | 64406075 |
Nervous system disorder | 17.35 | 12.57 | 52 | 56447 | 23026 | 64419207 |
Plasmodium falciparum infection | 17.21 | 12.57 | 5 | 56494 | 63 | 64442170 |
Plasmablastic lymphoma | 17.21 | 12.57 | 8 | 56491 | 401 | 64441832 |
Post inflammatory pigmentation change | 17.13 | 12.57 | 8 | 56491 | 405 | 64441828 |
Paraparesis | 16.92 | 12.57 | 18 | 56481 | 3484 | 64438749 |
Renal atrophy | 16.91 | 12.57 | 13 | 56486 | 1651 | 64440582 |
International normalised ratio increased | 16.90 | 12.57 | 27 | 56472 | 79140 | 64363093 |
Acute lymphocytic leukaemia | 16.89 | 12.57 | 20 | 56479 | 4351 | 64437882 |
Choroiditis | 16.87 | 12.57 | 11 | 56488 | 1076 | 64441157 |
Orthostatic hypotension | 16.85 | 12.57 | 10 | 56489 | 46728 | 64395505 |
Anal cancer stage 0 | 16.85 | 12.57 | 4 | 56495 | 21 | 64442212 |
Vomiting | 16.81 | 12.57 | 615 | 55884 | 550502 | 63891731 |
Gestational hypertension | 16.79 | 12.57 | 13 | 56486 | 1668 | 64440565 |
Hypersplenism | 16.70 | 12.57 | 8 | 56491 | 429 | 64441804 |
Blood uric acid decreased | 16.70 | 12.57 | 11 | 56488 | 1095 | 64441138 |
Small for dates baby | 16.67 | 12.57 | 8 | 56491 | 431 | 64441802 |
ADAMTS13 activity decreased | 16.65 | 12.57 | 6 | 56493 | 155 | 64442078 |
Benign hepatic neoplasm | 16.47 | 12.57 | 5 | 56494 | 74 | 64442159 |
Intentional product use issue | 16.42 | 12.57 | 37 | 56462 | 95327 | 64346906 |
Albuminuria | 16.39 | 12.57 | 9 | 56490 | 643 | 64441590 |
Drug reaction with eosinophilia and systemic symptoms | 16.34 | 12.57 | 92 | 56407 | 54125 | 64388108 |
Rectal haemorrhage | 16.34 | 12.57 | 18 | 56481 | 61799 | 64380434 |
Portal vein thrombosis | 16.33 | 12.57 | 21 | 56478 | 4970 | 64437263 |
Red blood cells urine | 16.32 | 12.57 | 9 | 56490 | 648 | 64441585 |
Influenza like illness | 16.27 | 12.57 | 18 | 56481 | 61684 | 64380549 |
Neurosyphilis | 16.26 | 12.57 | 4 | 56495 | 25 | 64442208 |
Musculoskeletal toxicity | 16.26 | 12.57 | 6 | 56493 | 166 | 64442067 |
Psychiatric decompensation | 16.25 | 12.57 | 15 | 56484 | 2448 | 64439785 |
Visual field defect | 16.07 | 12.57 | 27 | 56472 | 8119 | 64434114 |
Paraesthesia | 16.05 | 12.57 | 62 | 56437 | 134460 | 64307773 |
Kwashiorkor | 16.05 | 12.57 | 3 | 56496 | 3 | 64442230 |
Funisitis | 16.05 | 12.57 | 3 | 56496 | 3 | 64442230 |
Hepatitis B DNA decreased | 16.05 | 12.57 | 3 | 56496 | 3 | 64442230 |
Cervix operation | 16.05 | 12.57 | 3 | 56496 | 3 | 64442230 |
Wrong technique in product usage process | 16.01 | 12.57 | 20 | 56479 | 64954 | 64377279 |
Bone pain | 15.88 | 12.57 | 83 | 56416 | 47489 | 64394744 |
Eclampsia | 15.74 | 12.57 | 6 | 56493 | 182 | 64442051 |
Dry skin | 15.74 | 12.57 | 13 | 56486 | 51148 | 64391085 |
Ultrasound antenatal screen abnormal | 15.63 | 12.57 | 4 | 56495 | 30 | 64442203 |
Viral hepatitis carrier | 15.52 | 12.57 | 4 | 56495 | 31 | 64442202 |
Spermatozoa progressive motility abnormal | 15.52 | 12.57 | 4 | 56495 | 31 | 64442202 |
Genital herpes | 15.42 | 12.57 | 13 | 56486 | 1882 | 64440351 |
Drug dependence | 15.37 | 12.57 | 5 | 56494 | 33307 | 64408926 |
Acute hepatic failure | 15.27 | 12.57 | 54 | 56445 | 26058 | 64416175 |
Insomnia | 15.23 | 12.57 | 106 | 56393 | 197730 | 64244503 |
Blood pressure decreased | 15.21 | 12.57 | 33 | 56466 | 86166 | 64356067 |
Cardiac failure | 15.17 | 12.57 | 62 | 56437 | 132311 | 64309922 |
Ileal ulcer | 15.15 | 12.57 | 10 | 56489 | 998 | 64441235 |
Carnitine deficiency | 15.12 | 12.57 | 6 | 56493 | 203 | 64442030 |
Osteoarthritis | 15.09 | 12.57 | 20 | 56479 | 63316 | 64378917 |
Product prescribing error | 15.07 | 12.57 | 6 | 56493 | 35263 | 64406970 |
Hyperphosphataemia | 15.03 | 12.57 | 18 | 56481 | 3963 | 64438270 |
Ovarian failure | 15.03 | 12.57 | 8 | 56491 | 537 | 64441696 |
Atypical mycobacterial infection | 15.03 | 12.57 | 11 | 56488 | 1297 | 64440936 |
Portal vein occlusion | 14.99 | 12.57 | 4 | 56495 | 36 | 64442197 |
Brain oedema | 14.99 | 12.57 | 48 | 56451 | 22027 | 64420206 |
Dyspnoea exertional | 14.94 | 12.57 | 26 | 56473 | 73704 | 64368529 |
Secondary adrenocortical insufficiency | 14.92 | 12.57 | 14 | 56485 | 2331 | 64439902 |
Developmental delay | 14.90 | 12.57 | 10 | 56489 | 1027 | 64441206 |
Subacute sclerosing panencephalitis | 14.89 | 12.57 | 4 | 56495 | 37 | 64442196 |
Anogenital dysplasia | 14.89 | 12.57 | 5 | 56494 | 104 | 64442129 |
Therapeutic product effect incomplete | 14.86 | 12.57 | 44 | 56455 | 103438 | 64338795 |
Infected vasculitis | 14.83 | 12.57 | 3 | 56496 | 6 | 64442227 |
Carbon dioxide combining power abnormal | 14.83 | 12.57 | 3 | 56496 | 6 | 64442227 |
Glycocholic acid increased | 14.83 | 12.57 | 3 | 56496 | 6 | 64442227 |
Acute fatty liver of pregnancy | 14.79 | 12.57 | 4 | 56495 | 38 | 64442195 |
Heart rate irregular | 14.78 | 12.57 | 3 | 56496 | 27410 | 64414823 |
Eyelid oedema | 14.76 | 12.57 | 33 | 56466 | 12246 | 64429987 |
Glomerulonephritis proliferative | 14.74 | 12.57 | 7 | 56492 | 368 | 64441865 |
Hepatitis B surface antibody positive | 14.69 | 12.57 | 6 | 56493 | 219 | 64442014 |
Death neonatal | 14.61 | 12.57 | 4 | 56495 | 40 | 64442193 |
Blood glucose increased | 14.60 | 12.57 | 41 | 56458 | 98032 | 64344201 |
Limb discomfort | 14.60 | 12.57 | 3 | 56496 | 27172 | 64415061 |
Gastrointestinal haemorrhage | 14.52 | 12.57 | 63 | 56436 | 132249 | 64309984 |
Antiviral drug level below therapeutic | 14.52 | 12.57 | 4 | 56495 | 41 | 64442192 |
Portal fibrosis | 14.43 | 12.57 | 8 | 56491 | 582 | 64441651 |
Fat redistribution | 14.38 | 12.57 | 5 | 56494 | 116 | 64442117 |
Lipase increased | 14.37 | 12.57 | 36 | 56463 | 14366 | 64427867 |
CSF protein increased | 14.32 | 12.57 | 10 | 56489 | 1095 | 64441138 |
Pleocytosis | 14.30 | 12.57 | 10 | 56489 | 1097 | 64441136 |
Acute stress disorder | 14.26 | 12.57 | 7 | 56492 | 396 | 64441837 |
Crystal urine | 14.26 | 12.57 | 5 | 56494 | 119 | 64442114 |
Osteocalcin increased | 14.23 | 12.57 | 3 | 56496 | 8 | 64442225 |
Visual impairment | 14.23 | 12.57 | 27 | 56472 | 74050 | 64368183 |
Cytomegalovirus oesophagitis | 14.18 | 12.57 | 8 | 56491 | 602 | 64441631 |
Myopia | 14.18 | 12.57 | 12 | 56487 | 1746 | 64440487 |
Heart rate increased | 14.14 | 12.57 | 42 | 56457 | 98633 | 64343600 |
Burkitt's lymphoma | 14.14 | 12.57 | 5 | 56494 | 122 | 64442111 |
Breast cancer | 14.12 | 12.57 | 4 | 56495 | 29144 | 64413089 |
Cholestasis | 14.10 | 12.57 | 77 | 56422 | 44795 | 64397438 |
Hypervolaemia | 14.08 | 12.57 | 8 | 56491 | 38277 | 64403956 |
Emotional distress | 14.03 | 12.57 | 7 | 56492 | 36031 | 64406202 |
Hepatic necrosis | 14.02 | 12.57 | 26 | 56473 | 8447 | 64433786 |
Bone marrow oedema | 13.96 | 12.57 | 10 | 56489 | 1140 | 64441093 |
Antiviral drug level above therapeutic | 13.95 | 12.57 | 4 | 56495 | 48 | 64442185 |
Graft infection | 13.93 | 12.57 | 8 | 56491 | 623 | 64441610 |
Acute hepatitis B | 13.90 | 12.57 | 7 | 56492 | 419 | 64441814 |
Red blood cell sedimentation rate increased | 13.87 | 12.57 | 5 | 56494 | 31230 | 64411003 |
Genital ulceration | 13.79 | 12.57 | 8 | 56491 | 635 | 64441598 |
Optic neuropathy | 13.71 | 12.57 | 15 | 56484 | 2996 | 64439237 |
Blood creatine phosphokinase MB increased | 13.61 | 12.57 | 14 | 56485 | 2607 | 64439626 |
Hyperintensity in brain deep nuclei | 13.58 | 12.57 | 4 | 56495 | 53 | 64442180 |
Basal cell carcinoma | 13.58 | 12.57 | 5 | 56494 | 30833 | 64411400 |
Upper respiratory tract infection | 13.57 | 12.57 | 27 | 56472 | 72758 | 64369475 |
Blood pressure systolic increased | 13.51 | 12.57 | 14 | 56485 | 49439 | 64392794 |
Osteodystrophy | 13.51 | 12.57 | 3 | 56496 | 11 | 64442222 |
Pharyngotonsillitis | 13.47 | 12.57 | 6 | 56493 | 272 | 64441961 |
Prurigo | 13.45 | 12.57 | 10 | 56489 | 1207 | 64441026 |
Cervical dysplasia | 13.39 | 12.57 | 12 | 56487 | 1884 | 64440349 |
Head injury | 13.37 | 12.57 | 6 | 56493 | 32836 | 64409397 |
Colour vision tests abnormal | 13.31 | 12.57 | 3 | 56496 | 12 | 64442221 |
Multiple fractures | 13.24 | 12.57 | 21 | 56478 | 6019 | 64436214 |
Anaphylactic shock | 13.22 | 12.57 | 5 | 56494 | 30323 | 64411910 |
Cerebellar syndrome | 13.22 | 12.57 | 19 | 56480 | 4997 | 64437236 |
Acute on chronic liver failure | 13.21 | 12.57 | 6 | 56493 | 285 | 64441948 |
COVID-19 | 13.17 | 12.57 | 23 | 56476 | 65117 | 64377116 |
Bovine tuberculosis | 13.17 | 12.57 | 5 | 56494 | 150 | 64442083 |
Spinal cord injury | 13.17 | 12.57 | 9 | 56490 | 952 | 64441281 |
Agitation | 13.11 | 12.57 | 37 | 56462 | 88330 | 64353903 |
Spermatozoa progressive motility decreased | 13.07 | 12.57 | 4 | 56495 | 61 | 64442172 |
Ear pain | 13.04 | 12.57 | 3 | 56496 | 25133 | 64417100 |
Pulmonary embolism | 13.02 | 12.57 | 75 | 56424 | 146281 | 64295952 |
Trimethylaminuria | 12.98 | 12.57 | 5 | 56494 | 156 | 64442077 |
Acute HIV infection | 12.95 | 12.57 | 4 | 56495 | 63 | 64442170 |
Subchondral insufficiency fracture | 12.95 | 12.57 | 4 | 56495 | 63 | 64442170 |
Gastrooesophageal reflux disease | 12.94 | 12.57 | 34 | 56465 | 83109 | 64359124 |
Pneumonitis | 12.94 | 12.57 | 15 | 56484 | 50350 | 64391883 |
Neuroleptic malignant syndrome | 12.94 | 12.57 | 3 | 56496 | 24993 | 64417240 |
Pathological fracture | 12.90 | 12.57 | 26 | 56473 | 8979 | 64433254 |
Mesenteric vein thrombosis | 12.85 | 12.57 | 10 | 56489 | 1292 | 64440941 |
Musculoskeletal pain | 12.84 | 12.57 | 33 | 56466 | 81261 | 64360972 |
Melanaemia | 12.83 | 12.57 | 4 | 56495 | 65 | 64442168 |
Fungal infection | 12.82 | 12.57 | 7 | 56492 | 34244 | 64407989 |
Hepatitis D RNA positive | 12.76 | 12.57 | 3 | 56496 | 15 | 64442218 |
Congenital diaphragmatic hernia | 12.76 | 12.57 | 3 | 56496 | 15 | 64442218 |
Herpes virus infection | 12.72 | 12.57 | 21 | 56478 | 6223 | 64436010 |
Neurocryptococcosis | 12.60 | 12.57 | 3 | 56496 | 16 | 64442217 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Neutropenia | 40.77 | 39.38 | 22 | 527 | 190 | 83939 |
Source | Code | Description |
---|---|---|
ATC | J05AF05 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIVIRALS FOR SYSTEMIC USE DIRECT ACTING ANTIVIRALS Nucleoside and nucleotide reverse transcriptase inhibitors |
ATC | J05AR01 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIVIRALS FOR SYSTEMIC USE DIRECT ACTING ANTIVIRALS Antivirals for treatment of HIV infections, combinations |
ATC | J05AR02 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIVIRALS FOR SYSTEMIC USE DIRECT ACTING ANTIVIRALS Antivirals for treatment of HIV infections, combinations |
ATC | J05AR04 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIVIRALS FOR SYSTEMIC USE DIRECT ACTING ANTIVIRALS Antivirals for treatment of HIV infections, combinations |
ATC | J05AR05 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIVIRALS FOR SYSTEMIC USE DIRECT ACTING ANTIVIRALS Antivirals for treatment of HIV infections, combinations |
ATC | J05AR07 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIVIRALS FOR SYSTEMIC USE DIRECT ACTING ANTIVIRALS Antivirals for treatment of HIV infections, combinations |
ATC | J05AR11 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIVIRALS FOR SYSTEMIC USE DIRECT ACTING ANTIVIRALS Antivirals for treatment of HIV infections, combinations |
ATC | J05AR12 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIVIRALS FOR SYSTEMIC USE DIRECT ACTING ANTIVIRALS Antivirals for treatment of HIV infections, combinations |
ATC | J05AR13 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIVIRALS FOR SYSTEMIC USE DIRECT ACTING ANTIVIRALS Antivirals for treatment of HIV infections, combinations |
ATC | J05AR16 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIVIRALS FOR SYSTEMIC USE DIRECT ACTING ANTIVIRALS Antivirals for treatment of HIV infections, combinations |
ATC | J05AR24 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIVIRALS FOR SYSTEMIC USE DIRECT ACTING ANTIVIRALS Antivirals for treatment of HIV infections, combinations |
ATC | J05AR25 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIVIRALS FOR SYSTEMIC USE DIRECT ACTING ANTIVIRALS Antivirals for treatment of HIV infections, combinations |
ATC | J05AR27 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIVIRALS FOR SYSTEMIC USE DIRECT ACTING ANTIVIRALS Antivirals for treatment of HIV infections, combinations |
FDA MoA | N0000009947 | Nucleoside Reverse Transcriptase Inhibitors |
FDA EPC | N0000175462 | Human Immunodeficiency Virus Nucleoside Analog Reverse Transcriptase Inhibitor |
FDA EPC | N0000175656 | Hepatitis B Virus Nucleoside Analog Reverse Transcriptase Inhibitor |
CHEBI has role | CHEBI:36044 | antiviral drugs |
CHEBI has role | CHEBI:50266 | Prodrugs |
CHEBI has role | CHEBI:50904 | alergeno |
CHEBI has role | CHEBI:53756 | reverse transcriptase inhibitors |
CHEBI has role | CHEBI:64951 | anti-HBV agents |
MeSH PA | D019380 | Anti-HIV Agents |
MeSH PA | D000890 | Anti-Infective Agents |
MeSH PA | D044966 | Anti-Retroviral Agents |
MeSH PA | D000998 | Antiviral Agents |
MeSH PA | D004791 | Enzyme Inhibitors |
MeSH PA | D019384 | Nucleic Acid Synthesis Inhibitors |
MeSH PA | D018894 | Reverse Transcriptase Inhibitors |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Chronic type B viral hepatitis | indication | 61977001 | |
Human immunodeficiency virus infection | indication | 86406008 | DOID:526 |
Prevention of Hepatitis B Reactivation in Immunocompromised Patients | off-label use | ||
Prevention of HIV Infection after Exposure | off-label use | ||
Toxic amblyopia | contraindication | 965003 | |
Myositis | contraindication | 26889001 | DOID:633 |
Hepatic failure | contraindication | 59927004 | |
Pancreatitis | contraindication | 75694006 | DOID:4989 |
Large liver | contraindication | 80515008 | |
Kidney disease | contraindication | 90708001 | DOID:557 |
Lactic acidosis | contraindication | 91273001 | DOID:3650 |
Disorder of muscle | contraindication | 129565002 | DOID:423 |
Steatosis of liver | contraindication | 197321007 | |
Acute pancreatitis | contraindication | 197456007 | DOID:2913 |
Chronic pancreatitis | contraindication | 235494005 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Anemia | contraindication | 271737000 | DOID:2355 |
Hypertriglyceridemia | contraindication | 302870006 | |
Neutropenic disorder | contraindication | 303011007 | DOID:1227 |
Bone marrow depression | contraindication | 307762000 | |
Breastfeeding (mother) | contraindication | 413712001 | |
Obesity | contraindication | 414916001 | DOID:9970 |
Drug Resistance to Anti-retroviral Therapy | contraindication | ||
HLA-B 5701 Positive Status | contraindication |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 12.95 | acidic |
pKa2 | 4.18 | Basic |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
---|---|---|---|---|---|---|---|---|---|---|
150MG;EQ 300MG BASE | DUTREBIS | MERCK SHARP DOHME | N206510 | Feb. 6, 2015 | DISCN | TABLET | ORAL | 7217713 | Oct. 21, 2022 | TREATMENT OF HIV-1 INFECTION |
150MG;EQ 300MG BASE | DUTREBIS | MERCK SHARP DOHME | N206510 | Feb. 6, 2015 | DISCN | TABLET | ORAL | 7435734 | Oct. 21, 2022 | TREATMENT OF HIV-1 INFECTION |
150MG;EQ 300MG BASE | DUTREBIS | MERCK SHARP DOHME | N206510 | Feb. 6, 2015 | DISCN | TABLET | ORAL | 7754731 | March 11, 2029 | TREATMENT OF HIV-1 INFECTION |
EQ 50MG BASE;300MG | DOVATO | VIIV HLTHCARE | N211994 | April 8, 2019 | RX | TABLET | ORAL | 11234985 | Jan. 24, 2031 | TREATMENT OF HIV INFECTION |
100MG;300MG;300MG | DELSTRIGO | MSD MERCK CO | N210807 | Aug. 30, 2018 | RX | TABLET | ORAL | 8486975 | Oct. 7, 2031 | FOR THE TREATMENT OF HIV-1 INFECTION IN ADULT PATIENTS WITH NO PRIOR ANTIRETROVIRAL TREATMENT HISTORY |
100MG;300MG;300MG | DELSTRIGO | MSD MERCK CO | N210807 | Aug. 30, 2018 | RX | TABLET | ORAL | 8486975 | Oct. 7, 2031 | TREATMENT OF HIV-1 INFECTION IN ADULT PATIENTS AS A REPLACEMENT THERAPY IN VIROLOGICALLY SUPPRESSED ADULTS WITH NO HISTORY OF TREATMENT FAILURE AND NO KNOWN SUBSTITUTIONS ASSOCIATED WITH RESISTANCE TO THE INDIVIDUAL COMPONENTS OF DELSTRIGO |
100MG;300MG;300MG | DELSTRIGO | MSD MERCK CO | N210807 | Aug. 30, 2018 | RX | TABLET | ORAL | 8486975 | Oct. 7, 2031 | TREATMENT OF HIV-1 INFECTION IN PEDIATRIC PATIENTS WEIGHING AT LEAST 35KG WITH NO PRIOR ANTIRETROVIRAL TREATMENT HISTORY OR TO REPLACE THE CURRENT ANTIRETROVIRAL REGIMEN IN THOSE WHO ARE VIROLOGICALLY SUPPRESSED |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Exclusivity date | Description |
---|---|---|---|---|---|---|---|---|---|
EQ 50MG BASE;300MG | DOVATO | VIIV HLTHCARE | N211994 | April 8, 2019 | RX | TABLET | ORAL | April 8, 2022 | NEW COMBINATION |
100MG;300MG;300MG | DELSTRIGO | MSD MERCK CO | N210807 | Aug. 30, 2018 | RX | TABLET | ORAL | Sept. 19, 2022 | EXPANDED INDICATION FOR PTS WHO ARE VIROLOGICALLY SUPPRESSED (HIV-1 RNA LESS THAN 50 COPIES/ML) ON A STABLE ARV REGIMEN WITH NO HX OF TX FAILURE AND NO KNOWN SUBSTITUTIONS ASSOCIATED W RESISTANCE TO DORAVIRINE, LAMIVUDINE OR TENOFOVIR DISOPROXIL FUMARATE |
EQ 50MG BASE;300MG | DOVATO | VIIV HLTHCARE | N211994 | April 8, 2019 | RX | TABLET | ORAL | Aug. 6, 2023 | TO REPLACE THE CURRENT ANTIRETROVIRAL REGIMEN IN THOSE WHO ARE VIROLOGICALLY SUPRESSED (HIV-1 RNA LESS THAN 50 COPIES PER ML) ON A STABLE ANTIRETROVIRAL REGIMEN WITH NO HISTORY OF TREATMENT FAILURE |
100MG;300MG;300MG | DELSTRIGO | MSD MERCK CO | N210807 | Aug. 30, 2018 | RX | TABLET | ORAL | Aug. 30, 2023 | NEW CHEMICAL ENTITY |
100MG;300MG;300MG | DELSTRIGO | MSD MERCK CO | N210807 | Aug. 30, 2018 | RX | TABLET | ORAL | Jan. 27, 2025 | NEW PATIENT POPULATION |
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Deoxycytidine kinase | Kinase | WOMBAT-PK | |||||||
Protein P | Polyprotein | INHIBITOR | CHEMBL | CHEMBL | |||||
Reverse transcriptase/RNaseH | Enzyme | INHIBITOR | EC50 | 7.38 | CHEMBL | CHEMBL |
ID | Source |
---|---|
4020938 | VUID |
N0000148418 | NUI |
D00353 | KEGG_DRUG |
4020938 | VANDF |
C0209738 | UMLSCUI |
CHEBI:63577 | CHEBI |
3TC | PDB_CHEM_ID |
CHEMBL141 | ChEMBL_ID |
DB00709 | DRUGBANK_ID |
D019259 | MESH_DESCRIPTOR_UI |
60825 | PUBCHEM_CID |
6908 | INN_ID |
2T8Q726O95 | UNII |
68244 | RXNORM |
186277 | MMSL |
4956 | MMSL |
d03858 | MMSL |
005079 | NDDF |
108698001 | SNOMEDCT_US |
386897000 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
DELSTRIGO | HUMAN PRESCRIPTION DRUG LABEL | 3 | 0006-5007 | TABLET, FILM COATED | 300 mg | ORAL | NDA | 32 sections |
EPIVIRHBV | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0173-0662 | TABLET, FILM COATED | 100 mg | ORAL | NDA | 26 sections |
EPIVIRHBV | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0173-0663 | SOLUTION | 5 mg | ORAL | NDA | 26 sections |
LAMIVUDINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6583 | TABLET, FILM COATED | 150 mg | ORAL | ANDA | 27 sections |
Lamivudine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10135-605 | SOLUTION | 10 mg | ORAL | ANDA | 25 sections |
Combivir | HUMAN PRESCRIPTION DRUG LABEL | 2 | 16590-061 | TABLET, FILM COATED | 150 mg | ORAL | NDA | 16 sections |
EPIVIR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-367 | TABLET, FILM COATED | 150 mg | ORAL | NDA | 26 sections |
COMBIVIR | HUMAN PRESCRIPTION DRUG LABEL | 2 | 21695-846 | TABLET, FILM COATED | 150 mg | ORAL | NDA | 26 sections |
Lamivudine and Zidovudine | HUMAN PRESCRIPTION DRUG LABEL | 2 | 21695-996 | TABLET, FILM COATED | 150 mg | ORAL | ANDA | 26 sections |
lamivudine | Human Prescription Drug Label | 1 | 31722-001 | TABLET, FILM COATED | 100 mg | ORAL | ANDA | 25 sections |
LAMIVUDINE and ZIDOVUDINE | Human Prescription Drug Label | 2 | 31722-506 | TABLET, FILM COATED | 150 mg | ORAL | ANDA | 25 sections |
Lamivudine and Zidovudine | HUMAN PRESCRIPTION DRUG LABEL | 2 | 31722-739 | TABLET, FILM COATED | 150 mg | ORAL | ANDA | 24 sections |
Lamivudine | Human Prescription Drug Label | 1 | 31722-752 | TABLET, FILM COATED | 100 mg | ORAL | ANDA | 28 sections |
Lamivudine | Human Prescription Drug Label | 1 | 31722-753 | TABLET, FILM COATED | 150 mg | ORAL | ANDA | 25 sections |
Lamivudine | Human Prescription Drug Label | 1 | 31722-754 | TABLET, FILM COATED | 300 mg | ORAL | ANDA | 25 sections |
Lamivudine | Human Prescription Drug Label | 1 | 33342-001 | TABLET, FILM COATED | 150 mg | ORAL | ANDA | 26 sections |
Lamivudine | Human Prescription Drug Label | 1 | 33342-002 | TABLET, FILM COATED | 300 mg | ORAL | ANDA | 26 sections |
Lamivudine and Zidovudine | Human Prescription Drug Label | 2 | 33342-003 | TABLET | 150 mg | ORAL | ANDA | 25 sections |
Abacavir and Lamivudine | Human Prescription Drug Label | 2 | 35573-402 | TABLET, FILM COATED | 300 mg | ORAL | ANDA | 29 sections |
Abacavir and Lamivudine | Human Prescription Drug Label | 2 | 35573-430 | TABLET, FILM COATED | 300 mg | ORAL | ANDA | 27 sections |
Abacavir and Lamivudine | HUMAN PRESCRIPTION DRUG LABEL | 2 | 42291-115 | TABLET, FILM COATED | 300 mg | ORAL | ANDA | 28 sections |
Efavirenz, Lamivudine and Tenofovir Disoproxil Fumarate | Human Prescription Drug Label | 3 | 42385-928 | TABLET, FILM COATED | 300 mg | ORAL | ANDA | 30 sections |
Efavirenz, Lamivudine and Tenofovir Disoproxil Fumarate | Human Prescription Drug Label | 3 | 42385-929 | TABLET, FILM COATED | 300 mg | ORAL | ANDA | 30 sections |
LAMIVUDINE and ZIDOVUDINE | HUMAN PRESCRIPTION DRUG LABEL | 2 | 43063-900 | TABLET, FILM COATED | 150 mg | ORAL | ANDA | 25 sections |
SYMFI LO | HUMAN PRESCRIPTION DRUG LABEL | 3 | 49502-425 | TABLET, FILM COATED | 300 mg | ORAL | NDA | 32 sections |
CIMDUO | HUMAN PRESCRIPTION DRUG LABEL | 2 | 49502-450 | TABLET, FILM COATED | 300 mg | ORAL | NDA | 29 sections |
SYMFI | HUMAN PRESCRIPTION DRUG LABEL | 3 | 49502-475 | TABLET, FILM COATED | 300 mg | ORAL | NDA | 31 sections |
COMBIVIR | HUMAN PRESCRIPTION DRUG LABEL | 2 | 49702-202 | TABLET, FILM COATED | 150 mg | ORAL | NDA | 25 sections |
EPIVIR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 49702-203 | TABLET, FILM COATED | 150 mg | ORAL | NDA | 25 sections |
EPIVIR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 49702-204 | TABLET, FILM COATED | 300 mg | ORAL | NDA | 25 sections |