Stem definition | Drug id | CAS RN |
---|---|---|
antivirals | 88 | 142340-99-6 |
Dose | Unit | Route |
---|---|---|
10 | mg | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Bocci G, Oprea TI, Benet LZ |
S (Water solubility) | 0.40 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 45 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 0.43 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 12 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Date | Agency | Company | Orphan |
---|---|---|---|
March 6, 2003 | EMA | ||
Sept. 20, 2002 | FDA | GILEAD |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Osteomalacia | 631.22 | 53.28 | 86 | 1708 | 659 | 63486569 |
Fanconi syndrome acquired | 452.59 | 53.28 | 67 | 1727 | 969 | 63486259 |
Hypophosphataemia | 330.02 | 53.28 | 74 | 1720 | 11352 | 63475876 |
Drug resistance | 213.33 | 53.28 | 60 | 1734 | 22873 | 63464355 |
Osteoporosis | 166.61 | 53.28 | 62 | 1732 | 57276 | 63429952 |
Bone pain | 154.76 | 53.28 | 58 | 1736 | 54583 | 63432645 |
Hypophosphataemic osteomalacia | 149.76 | 53.28 | 21 | 1773 | 199 | 63487029 |
Fanconi syndrome | 143.07 | 53.28 | 26 | 1768 | 1366 | 63485862 |
Blood phosphorus decreased | 129.12 | 53.28 | 29 | 1765 | 4424 | 63482804 |
Renal tubular disorder | 114.43 | 53.28 | 24 | 1770 | 2658 | 63484570 |
Hepatitis B DNA increased | 91.12 | 53.28 | 14 | 1780 | 259 | 63486969 |
Viral load increased | 80.45 | 53.28 | 16 | 1778 | 1358 | 63485870 |
Hypouricaemia | 75.15 | 53.28 | 11 | 1783 | 144 | 63487084 |
Pathogen resistance | 74.41 | 53.28 | 20 | 1774 | 6378 | 63480850 |
Viral mutation identified | 70.33 | 53.28 | 15 | 1779 | 1795 | 63485433 |
Aminoaciduria | 69.12 | 53.28 | 10 | 1784 | 120 | 63487108 |
Blood alkaline phosphatase increased | 67.66 | 53.28 | 30 | 1764 | 42937 | 63444291 |
Glycosuria | 58.85 | 53.28 | 12 | 1782 | 1154 | 63486074 |
Renal tubular dysfunction | 57.05 | 53.28 | 10 | 1784 | 425 | 63486803 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Osteomalacia | 1784.18 | 53.18 | 274 | 5577 | 643 | 34950437 |
Hypophosphataemia | 935.05 | 53.18 | 240 | 5611 | 10786 | 34940294 |
Fanconi syndrome acquired | 861.47 | 53.18 | 165 | 5686 | 1826 | 34949254 |
Drug resistance | 482.56 | 53.18 | 176 | 5675 | 25751 | 34925329 |
Osteoporosis | 429.39 | 53.18 | 135 | 5716 | 12533 | 34938547 |
Fanconi syndrome | 405.08 | 53.18 | 86 | 5765 | 1634 | 34949446 |
Blood phosphorus decreased | 383.24 | 53.18 | 92 | 5759 | 3089 | 34947991 |
Viral mutation identified | 369.14 | 53.18 | 88 | 5763 | 2866 | 34948214 |
Hypophosphataemic osteomalacia | 357.78 | 53.18 | 53 | 5798 | 84 | 34950996 |
Bone pain | 310.10 | 53.18 | 120 | 5731 | 20566 | 34930514 |
Hepatitis B DNA increased | 245.09 | 53.18 | 47 | 5804 | 518 | 34950562 |
Multiple fractures | 216.78 | 53.18 | 50 | 5801 | 1402 | 34949678 |
Hypouricaemia | 199.03 | 53.18 | 35 | 5816 | 227 | 34950853 |
Blood alkaline phosphatase increased | 195.38 | 53.18 | 98 | 5753 | 31077 | 34920003 |
Renal tubular disorder | 188.87 | 53.18 | 57 | 5794 | 4586 | 34946494 |
Bone density decreased | 177.67 | 53.18 | 45 | 5806 | 1884 | 34949196 |
Pathogen resistance | 163.48 | 53.18 | 61 | 5790 | 9421 | 34941659 |
Urine phosphorus increased | 156.99 | 53.18 | 23 | 5828 | 32 | 34951048 |
Viral load increased | 156.31 | 53.18 | 43 | 5808 | 2484 | 34948596 |
Hepatic cancer | 138.13 | 53.18 | 52 | 5799 | 8223 | 34942857 |
Multiple-drug resistance | 125.41 | 53.18 | 43 | 5808 | 5196 | 34945884 |
Blood creatinine increased | 125.33 | 53.18 | 113 | 5738 | 94863 | 34856217 |
Glycosuria | 109.67 | 53.18 | 28 | 5823 | 1209 | 34949871 |
Renal impairment | 102.69 | 53.18 | 101 | 5750 | 94412 | 34856668 |
Proteinuria | 94.81 | 53.18 | 51 | 5800 | 18591 | 34932489 |
Aminoaciduria | 94.51 | 53.18 | 19 | 5832 | 271 | 34950809 |
Glucose urine present | 93.89 | 53.18 | 24 | 5827 | 1041 | 34950039 |
Hepatocellular carcinoma | 92.91 | 53.18 | 38 | 5813 | 7471 | 34943609 |
Hepatitis B reactivation | 89.48 | 53.18 | 31 | 5820 | 3860 | 34947220 |
Gait disturbance | 88.77 | 53.18 | 89 | 5762 | 85051 | 34866029 |
Arthralgia | 87.75 | 53.18 | 124 | 5727 | 169917 | 34781163 |
Renal tubular dysfunction | 86.96 | 53.18 | 19 | 5832 | 413 | 34950667 |
Renal glycosuria | 84.55 | 53.18 | 12 | 5839 | 11 | 34951069 |
Genotype drug resistance test positive | 82.58 | 53.18 | 22 | 5829 | 1123 | 34949957 |
Urine phosphorus decreased | 82.29 | 53.18 | 13 | 5838 | 38 | 34951042 |
Hepatitis B | 79.94 | 53.18 | 32 | 5819 | 5951 | 34945129 |
Urine calcium increased | 74.32 | 53.18 | 12 | 5839 | 42 | 34951038 |
Bone marrow oedema | 68.45 | 53.18 | 17 | 5834 | 655 | 34950425 |
Fracture | 65.90 | 53.18 | 29 | 5822 | 6820 | 34944260 |
Blood uric acid decreased | 62.78 | 53.18 | 14 | 5837 | 335 | 34950745 |
Protein urine present | 59.73 | 53.18 | 25 | 5826 | 5203 | 34945877 |
Alanine aminotransferase increased | 55.59 | 53.18 | 68 | 5783 | 80747 | 34870333 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Osteomalacia | 2289.81 | 46.89 | 330 | 6179 | 1150 | 79736729 |
Hypophosphataemia | 1185.00 | 46.89 | 283 | 6226 | 19630 | 79718249 |
Fanconi syndrome acquired | 1159.06 | 46.89 | 199 | 6310 | 2495 | 79735384 |
Drug resistance | 557.91 | 46.89 | 185 | 6324 | 42028 | 79695851 |
Hypophosphataemic osteomalacia | 505.97 | 46.89 | 74 | 6435 | 286 | 79737593 |
Viral mutation identified | 482.93 | 46.89 | 101 | 6408 | 3757 | 79734122 |
Osteoporosis | 475.56 | 46.89 | 175 | 6334 | 53937 | 79683942 |
Fanconi syndrome | 434.98 | 46.89 | 88 | 6421 | 2768 | 79735111 |
Bone pain | 408.88 | 46.89 | 158 | 6351 | 55584 | 79682295 |
Blood phosphorus decreased | 386.31 | 46.89 | 93 | 6416 | 6575 | 79731304 |
Pathogen resistance | 263.85 | 46.89 | 81 | 6428 | 14261 | 79723618 |
Hepatitis B DNA increased | 241.97 | 46.89 | 44 | 6465 | 771 | 79737108 |
Blood alkaline phosphatase increased | 234.89 | 46.89 | 111 | 6398 | 63553 | 79674326 |
Hypouricaemia | 234.49 | 46.89 | 39 | 6470 | 393 | 79737486 |
Renal tubular disorder | 219.89 | 46.89 | 59 | 6450 | 6427 | 79731452 |
Viral load increased | 201.32 | 46.89 | 47 | 6462 | 2901 | 79734978 |
Urine phosphorus increased | 186.24 | 46.89 | 26 | 6483 | 65 | 79737814 |
Glycosuria | 160.63 | 46.89 | 37 | 6472 | 2151 | 79735728 |
Multiple-drug resistance | 150.35 | 46.89 | 47 | 6462 | 8761 | 79729118 |
Renal tubular dysfunction | 148.76 | 46.89 | 29 | 6480 | 748 | 79737131 |
Hepatitis B reactivation | 144.85 | 46.89 | 42 | 6467 | 6066 | 79731813 |
Bone density decreased | 138.77 | 46.89 | 49 | 6460 | 13298 | 79724581 |
Multiple fractures | 137.71 | 46.89 | 43 | 6466 | 7983 | 79729896 |
Genotype drug resistance test positive | 128.11 | 46.89 | 28 | 6481 | 1280 | 79736599 |
Proteinuria | 123.81 | 46.89 | 58 | 6451 | 32444 | 79705435 |
Hepatocellular carcinoma | 120.65 | 46.89 | 40 | 6469 | 8981 | 79728898 |
Hepatic cancer | 118.45 | 46.89 | 41 | 6468 | 10488 | 79727391 |
Renal impairment | 118.43 | 46.89 | 100 | 6409 | 157683 | 79580196 |
Renal glycosuria | 112.68 | 46.89 | 15 | 6494 | 22 | 79737857 |
Glucose urine present | 109.41 | 46.89 | 26 | 6483 | 1730 | 79736149 |
Blood creatinine increased | 101.65 | 46.89 | 91 | 6418 | 154966 | 79582913 |
Gait disturbance | 96.83 | 46.89 | 101 | 6408 | 207405 | 79530474 |
Aminoaciduria | 95.95 | 46.89 | 18 | 6491 | 376 | 79737503 |
Urine phosphorus decreased | 90.88 | 46.89 | 13 | 6496 | 41 | 79737838 |
Nephropathy toxic | 82.59 | 46.89 | 38 | 6471 | 20381 | 79717498 |
Rib fracture | 76.96 | 46.89 | 40 | 6469 | 27907 | 79709972 |
Acquired aminoaciduria | 76.26 | 46.89 | 10 | 6499 | 12 | 79737867 |
Blood uric acid decreased | 74.70 | 46.89 | 18 | 6491 | 1270 | 79736609 |
Urine calcium increased | 74.07 | 46.89 | 12 | 6497 | 101 | 79737778 |
Hyperphosphatasaemia | 74.07 | 46.89 | 12 | 6497 | 101 | 79737778 |
Femoral neck fracture | 68.38 | 46.89 | 27 | 6482 | 9957 | 79727922 |
Arthralgia | 66.79 | 46.89 | 145 | 6364 | 571658 | 79166221 |
Hyperphosphaturia | 66.75 | 46.89 | 11 | 6498 | 104 | 79737775 |
Bone marrow oedema | 64.79 | 46.89 | 17 | 6492 | 1694 | 79736185 |
Renal tubular acidosis | 64.66 | 46.89 | 20 | 6489 | 3594 | 79734285 |
Hepatitis B | 58.70 | 46.89 | 23 | 6486 | 8309 | 79729570 |
Muscular weakness | 55.59 | 46.89 | 67 | 6442 | 160662 | 79577217 |
Protein urine present | 54.39 | 46.89 | 23 | 6486 | 10089 | 79727790 |
Back pain | 52.37 | 46.89 | 91 | 6418 | 304089 | 79433790 |
Beta 2 microglobulin urine increased | 50.72 | 46.89 | 9 | 6500 | 136 | 79737743 |
Blood phosphorus abnormal | 50.32 | 46.89 | 10 | 6499 | 285 | 79737594 |
None
Source | Code | Description |
---|---|---|
ATC | J05AF08 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIVIRALS FOR SYSTEMIC USE DIRECT ACTING ANTIVIRALS Nucleoside and nucleotide reverse transcriptase inhibitors |
FDA MoA | N0000009947 | Nucleoside Reverse Transcriptase Inhibitors |
FDA EXT | N0000175459 | Nucleoside Analog |
CHEBI has role | CHEBI:36044 | antiviral drugs |
CHEBI has role | CHEBI:49103 | drug metabolites |
CHEBI has role | CHEBI:50909 | agente nefrotoxico |
CHEBI has role | CHEBI:53756 | reverse transcriptase inhibitors |
CHEBI has role | CHEBI:59517 | DNA synthesis inhibitors |
MeSH PA | D000890 | Anti-Infective Agents |
MeSH PA | D000998 | Antiviral Agents |
MeSH PA | D004791 | Enzyme Inhibitors |
MeSH PA | D019384 | Nucleic Acid Synthesis Inhibitors |
MeSH PA | D018894 | Reverse Transcriptase Inhibitors |
FDA EPC | N0000175656 | Hepatitis B Virus Nucleoside Analog Reverse Transcriptase Inhibitor |
CHEBI has role | CHEBI:50266 | Prodrugs |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Chronic type B viral hepatitis | indication | 61977001 | |
Kidney disease | contraindication | 90708001 | DOID:557 |
Lactic acidosis | contraindication | 91273001 | DOID:3650 |
Steatosis of liver | contraindication | 197321007 | |
Toxic nephropathy | contraindication | 236514003 | |
Breastfeeding (mother) | contraindication | 413712001 | |
Obesity | contraindication | 414916001 | DOID:9970 |
Drug Resistance to Anti-retroviral Therapy | contraindication |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 4.73 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
DNA polymerase subunit gamma-1 | Enzyme | WOMBAT-PK | |||||||
Protein P | Polyprotein | INHIBITOR | CHEMBL | CHEMBL | |||||
Capsid protein | Unclassified | EC50 | 7.08 | CHEMBL |
ID | Source |
---|---|
4021357 | VUID |
N0000179520 | NUI |
141400 | RXNORM |
C0540694 | UMLSCUI |
CHEBI:31175 | CHEBI |
CHEBI:2469 | CHEBI |
CHEMBL922 | ChEMBL_ID |
DB00718 | DRUGBANK_ID |
C106812 | MESH_SUPPLEMENTAL_RECORD_UI |
C053001 | MESH_SUPPLEMENTAL_RECORD_UI |
U6Q8Z01514 | UNII |
60871 | PUBCHEM_CID |
DB13868 | DRUGBANK_ID |
409114008 | SNOMEDCT_US |
412072006 | SNOMEDCT_US |
412073001 | SNOMEDCT_US |
C0050175 | UMLSCUI |
CHEMBL484 | ChEMBL_ID |
4021357 | VANDF |
4024286 | VANDF |
7313 | INN_ID |
106941-25-7 | SECONDARY_CAS_RN |
60172 | PUBCHEM_CID |
16958 | MMSL |
205746 | MMSL |
44701 | MMSL |
d04814 | MMSL |
6GQP90I798 | UNII |
009376 | NDDF |
009377 | NDDF |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
ADEFOVIR DIPIVOXIL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42794-003 | TABLET | 10 mg | ORAL | ANDA | 29 sections |
ADEFOVIR DIPIVOXIL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42794-003 | TABLET | 10 mg | ORAL | ANDA | 29 sections |
Hepsera | HUMAN PRESCRIPTION DRUG LABEL | 1 | 46014-0501 | TABLET | 10 mg | ORAL | NDA | 32 sections |
Adefovir dipivoxil | HUMAN PRESCRIPTION DRUG LABEL | 1 | 60505-3947 | TABLET | 10 mg | ORAL | ANDA | 29 sections |
Adefovir dipivoxil | HUMAN PRESCRIPTION DRUG LABEL | 1 | 60505-3947 | TABLET | 10 mg | ORAL | ANDA | 29 sections |
Hepsera | HUMAN PRESCRIPTION DRUG LABEL | 1 | 61958-0501 | TABLET | 10 mg | ORAL | NDA | 29 sections |
Hepsera | HUMAN PRESCRIPTION DRUG LABEL | 1 | 61958-0501 | TABLET | 10 mg | ORAL | NDA | 29 sections |