Molfile
Inchi
Smiles
Synonyms:
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bictegravir
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bictegravir sodium
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GS-9883
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GS-9883-01
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Bictegravir inhibits the strand transfer activity of HIV-1 integrase (integrase strand transfer inhibitor; INSTI), an HIV-1 encoded enzyme that is required for viral replication. Inhibition of integrase prevents the integration of linear HIV-1 DNA into host genomic DNA, blocking the formation of the HIV-1 provirus and propagation of the virus.
- Molecular weight: 449.39
- Formula: C21H18F3N3O5
- CLOGP: 0.02
- LIPINSKI: 0
- HAC: 8
- HDO: 2
- TPSA: 99.18
- ALOGS: -3.92
- ROTB: 3
- Status: ONP
Legend: OFP - off patent OFM - off market ONP - on patent
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