Molfile
Inchi
Smiles
Synonyms:
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Ro 24-2027/000
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hivid
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zalcitabine
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dideoxycytidine
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A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication at low concentrations, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Its principal toxic side effect is axonal degeneration resulting in peripheral neuropathy.
- Molecular weight: 211.22
- Formula: C9H13N3O3
- CLOGP: -1.25
- LIPINSKI: 0
- HAC: 6
- HDO: 2
- TPSA: 88.15
- ALOGS: -1.48
- ROTB: 2
- Status: OFM
Legend: OFP - off patent OFM - off market ONP - on patent
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