Stem definition | Drug id | CAS RN |
---|---|---|
antivirals | 2593 | 201341-05-1 |
Dose | Unit | Route |
---|---|---|
0.25 | g | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Bocci G, Oprea TI, Benet LZ |
S (Water solubility) | 16.67 mg/mL | Bocci G, Oprea TI, Benet LZ |
EoM (Fraction excreted unchanged in urine) | 82 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 6.43 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 0.25 % | Kawashima H, Watanabe R, Esaki T, Kuroda M, Nagao C, Natsume-Kitatani Y, Ohashi R, Komura H, Mizuguchi K |
Date | Agency | Company | Orphan |
---|---|---|---|
Feb. 4, 2002 | EMA | Gilead Sciences Ireland UC | |
Oct. 26, 2001 | FDA | GILEAD SCIENCES INC |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Abortion spontaneous | 1316.41 | 17.98 | 498 | 17750 | 46697 | 63424077 |
Exposure during pregnancy | 718.91 | 17.98 | 484 | 17764 | 155063 | 63315711 |
Foetal exposure during pregnancy | 674.28 | 17.98 | 276 | 17972 | 31686 | 63439088 |
Maternal exposure during pregnancy | 518.30 | 17.98 | 459 | 17789 | 219603 | 63251171 |
Virologic failure | 508.84 | 17.98 | 116 | 18132 | 1746 | 63469028 |
Fanconi syndrome acquired | 505.60 | 17.98 | 104 | 18144 | 932 | 63469842 |
Stillbirth | 461.51 | 17.98 | 140 | 18108 | 6610 | 63464164 |
Viral mutation identified | 431.93 | 17.98 | 101 | 18147 | 1709 | 63469065 |
Pregnancy | 381.70 | 17.98 | 194 | 18054 | 36642 | 63434132 |
Abortion induced | 354.46 | 17.98 | 127 | 18121 | 10115 | 63460659 |
Drug resistance | 319.64 | 17.98 | 148 | 18100 | 22785 | 63447989 |
Immune reconstitution inflammatory syndrome | 302.60 | 17.98 | 99 | 18149 | 5985 | 63464789 |
Premature baby | 270.95 | 17.98 | 128 | 18120 | 20607 | 63450167 |
Viral load increased | 257.05 | 17.98 | 63 | 18185 | 1311 | 63469463 |
Blood HIV RNA increased | 256.48 | 17.98 | 56 | 18192 | 683 | 63470091 |
Pathogen resistance | 254.44 | 17.98 | 88 | 18160 | 6310 | 63464464 |
Osteoporosis | 202.69 | 17.98 | 152 | 18096 | 57186 | 63413588 |
Renal tubular disorder | 197.79 | 17.98 | 59 | 18189 | 2623 | 63468151 |
Caesarean section | 185.93 | 17.98 | 93 | 18155 | 16939 | 63453835 |
Genotype drug resistance test positive | 185.31 | 17.98 | 39 | 18209 | 394 | 63470380 |
Nephropathy toxic | 179.84 | 17.98 | 76 | 18172 | 9403 | 63461371 |
Hepatitis B DNA increased | 172.54 | 17.98 | 34 | 18214 | 239 | 63470535 |
Premature labour | 171.98 | 17.98 | 80 | 18168 | 12424 | 63458350 |
Premature delivery | 167.94 | 17.98 | 106 | 18142 | 30175 | 63440599 |
Renal tubular acidosis | 159.28 | 17.98 | 45 | 18203 | 1647 | 63469127 |
Fanconi syndrome | 149.26 | 17.98 | 41 | 18207 | 1351 | 63469423 |
Lipodystrophy acquired | 147.55 | 17.98 | 41 | 18207 | 1411 | 63469363 |
Arthrodesis | 145.01 | 17.98 | 47 | 18201 | 2754 | 63468020 |
Hepatic cytolysis | 136.14 | 17.98 | 73 | 18175 | 15334 | 63455440 |
Hyperandrogenism | 134.57 | 17.98 | 24 | 18224 | 89 | 63470685 |
CD4 lymphocytes decreased | 134.54 | 17.98 | 38 | 18210 | 1389 | 63469385 |
Enlarged clitoris | 132.83 | 17.98 | 25 | 18223 | 133 | 63470641 |
Glycosuria | 132.73 | 17.98 | 36 | 18212 | 1130 | 63469644 |
Renal tubular dysfunction | 129.10 | 17.98 | 29 | 18219 | 406 | 63470368 |
Live birth | 127.97 | 17.98 | 84 | 18164 | 25546 | 63445228 |
Hypophosphataemia | 126.49 | 17.98 | 63 | 18185 | 11363 | 63459411 |
Proteinuria | 121.35 | 17.98 | 73 | 18175 | 19072 | 63451702 |
Osteomalacia | 118.51 | 17.98 | 30 | 18218 | 715 | 63470059 |
Acute kidney injury | 118.03 | 17.98 | 244 | 18004 | 263171 | 63207603 |
Hepatitis B reactivation | 112.64 | 17.98 | 40 | 18208 | 3097 | 63467677 |
Premature rupture of membranes | 104.68 | 17.98 | 43 | 18205 | 4950 | 63465824 |
Foetal death | 102.57 | 17.98 | 54 | 18194 | 10926 | 63459848 |
Rebound effect | 101.82 | 17.98 | 41 | 18207 | 4485 | 63466289 |
Renal failure | 93.03 | 17.98 | 140 | 18108 | 117512 | 63353262 |
Cushing's syndrome | 91.42 | 17.98 | 24 | 18224 | 663 | 63470111 |
Alanine aminotransferase increased | 90.01 | 17.98 | 129 | 18119 | 103641 | 63367133 |
Treatment noncompliance | 85.61 | 17.98 | 77 | 18171 | 37248 | 63433526 |
Renal tubular necrosis | 85.00 | 17.98 | 49 | 18199 | 11829 | 63458945 |
Hydrops foetalis | 84.57 | 17.98 | 22 | 18226 | 586 | 63470188 |
Pain | 81.44 | 17.98 | 57 | 18191 | 740571 | 62730203 |
Oligohydramnios | 76.11 | 17.98 | 37 | 18211 | 6329 | 63464445 |
Jaundice | 74.40 | 17.98 | 64 | 18184 | 29187 | 63441587 |
Fatigue | 74.30 | 17.98 | 88 | 18160 | 887940 | 62582834 |
Joint swelling | 71.87 | 17.98 | 6 | 18242 | 327660 | 63143114 |
CSF HIV escape syndrome | 71.73 | 17.98 | 14 | 18234 | 93 | 63470681 |
Hyperbilirubinaemia | 71.32 | 17.98 | 43 | 18205 | 11271 | 63459503 |
Aspartate aminotransferase increased | 67.90 | 17.98 | 105 | 18143 | 90172 | 63380602 |
Ultrasound antenatal screen abnormal | 67.29 | 17.98 | 14 | 18234 | 133 | 63470641 |
Malaria | 67.10 | 17.98 | 15 | 18233 | 205 | 63470569 |
Meningomyelocele | 65.32 | 17.98 | 18 | 18230 | 600 | 63470174 |
Placental disorder | 64.90 | 17.98 | 22 | 18226 | 1482 | 63469292 |
Maternal drugs affecting foetus | 64.28 | 17.98 | 31 | 18217 | 5211 | 63465563 |
Osteonecrosis | 63.05 | 17.98 | 54 | 18194 | 24476 | 63446298 |
Hypophosphataemic osteomalacia | 61.67 | 17.98 | 14 | 18234 | 206 | 63470568 |
Pre-eclampsia | 60.92 | 17.98 | 36 | 18212 | 9097 | 63461677 |
Placenta praevia | 60.49 | 17.98 | 19 | 18229 | 1005 | 63469769 |
Blood phosphorus decreased | 59.69 | 17.98 | 28 | 18220 | 4425 | 63466349 |
Infusion related reaction | 58.22 | 17.98 | 3 | 18245 | 245518 | 63225256 |
Placental insufficiency | 57.97 | 17.98 | 20 | 18228 | 1421 | 63469353 |
Congenital anomaly | 57.58 | 17.98 | 21 | 18227 | 1755 | 63469019 |
Haemolytic anaemia | 57.49 | 17.98 | 36 | 18212 | 10089 | 63460685 |
Hepatitis B | 57.45 | 17.98 | 26 | 18222 | 3786 | 63466988 |
Renal colic | 57.43 | 17.98 | 20 | 18228 | 1461 | 63469313 |
Foetal growth restriction | 56.30 | 17.98 | 32 | 18216 | 7521 | 63463253 |
Congenital choroid plexus cyst | 56.24 | 17.98 | 14 | 18234 | 311 | 63470463 |
Macrocephaly | 55.37 | 17.98 | 11 | 18237 | 81 | 63470693 |
Blood creatinine increased | 54.95 | 17.98 | 94 | 18154 | 87750 | 63383024 |
Hepatitis fulminant | 53.39 | 17.98 | 24 | 18224 | 3440 | 63467334 |
Shoulder arthroplasty | 53.14 | 17.98 | 25 | 18223 | 3977 | 63466797 |
Peripheral swelling | 52.84 | 17.98 | 7 | 18241 | 265935 | 63204839 |
Fall | 51.85 | 17.98 | 24 | 18224 | 392310 | 63078464 |
Hemivertebra | 51.66 | 17.98 | 11 | 18237 | 118 | 63470656 |
Cleft lip and palate | 51.32 | 17.98 | 15 | 18233 | 620 | 63470154 |
Limb operation | 49.91 | 17.98 | 24 | 18224 | 4007 | 63466767 |
Nasopharyngitis | 49.78 | 17.98 | 7 | 18241 | 254250 | 63216524 |
Neonatal respiratory distress syndrome | 48.18 | 17.98 | 21 | 18227 | 2797 | 63467977 |
Congenital umbilical hernia | 46.81 | 17.98 | 12 | 18236 | 301 | 63470473 |
Ectopic pregnancy | 46.74 | 17.98 | 20 | 18228 | 2547 | 63468227 |
Arnold-Chiari malformation | 46.31 | 17.98 | 14 | 18234 | 651 | 63470123 |
Lactic acidosis | 46.18 | 17.98 | 56 | 18192 | 38231 | 63432543 |
Systemic lupus erythematosus | 45.30 | 17.98 | 4 | 18244 | 208914 | 63261860 |
Metabolic acidosis | 43.47 | 17.98 | 59 | 18189 | 45010 | 63425764 |
HIV infection | 43.23 | 17.98 | 12 | 18236 | 411 | 63470363 |
Congenital hydrocephalus | 42.86 | 17.98 | 10 | 18238 | 167 | 63470607 |
Sinusitis | 42.62 | 17.98 | 7 | 18241 | 226646 | 63244128 |
Birth mark | 42.32 | 17.98 | 10 | 18238 | 177 | 63470597 |
Gestational diabetes | 40.63 | 17.98 | 27 | 18221 | 8369 | 63462405 |
Ultrasound antenatal screen | 40.43 | 17.98 | 10 | 18238 | 216 | 63470558 |
Dyspnoea | 40.31 | 17.98 | 81 | 18167 | 661232 | 62809542 |
Ventricular septal defect | 39.38 | 17.98 | 21 | 18227 | 4357 | 63466417 |
Multiple-drug resistance | 38.79 | 17.98 | 22 | 18226 | 5148 | 63465626 |
Hepatitis B DNA assay positive | 38.63 | 17.98 | 7 | 18241 | 29 | 63470745 |
Transaminases increased | 38.02 | 17.98 | 46 | 18202 | 31321 | 63439453 |
Acquired immunodeficiency syndrome | 37.99 | 17.98 | 8 | 18240 | 81 | 63470693 |
Drug interaction | 37.88 | 17.98 | 148 | 18100 | 228983 | 63241791 |
Patent ductus arteriosus | 37.14 | 17.98 | 20 | 18228 | 4230 | 63466544 |
Arthralgia | 37.13 | 17.98 | 67 | 18181 | 569643 | 62901131 |
Foetal distress syndrome | 36.72 | 17.98 | 14 | 18234 | 1324 | 63469450 |
Hydromyelia | 36.34 | 17.98 | 6 | 18242 | 12 | 63470762 |
Musculoskeletal stiffness | 36.32 | 17.98 | 5 | 18243 | 184613 | 63286161 |
Drug intolerance | 36.16 | 17.98 | 22 | 18226 | 308639 | 63162135 |
Normal newborn | 36.02 | 17.98 | 25 | 18223 | 8316 | 63462458 |
Polyhydramnios | 35.85 | 17.98 | 16 | 18232 | 2255 | 63468519 |
Rash maculo-papular | 35.80 | 17.98 | 45 | 18203 | 31851 | 63438923 |
Immune reconstitution inflammatory syndrome associated tuberculosis | 35.55 | 17.98 | 10 | 18238 | 360 | 63470414 |
AIDS cholangiopathy | 35.42 | 17.98 | 6 | 18242 | 15 | 63470759 |
Antiviral drug level below therapeutic | 35.18 | 17.98 | 7 | 18241 | 52 | 63470722 |
Human immunodeficiency virus transmission | 35.06 | 17.98 | 7 | 18241 | 53 | 63470721 |
Spina bifida | 34.86 | 17.98 | 12 | 18236 | 847 | 63469927 |
Blood creatine phosphokinase MB increased | 34.36 | 17.98 | 13 | 18235 | 1203 | 63469571 |
Cholestasis of pregnancy | 34.27 | 17.98 | 13 | 18235 | 1212 | 63469562 |
Adrenal suppression | 34.00 | 17.98 | 12 | 18236 | 912 | 63469862 |
Hepatitis | 33.77 | 17.98 | 49 | 18199 | 39739 | 63431035 |
Anaemia | 33.71 | 17.98 | 170 | 18078 | 293260 | 63177514 |
Pulmonary tuberculosis | 33.29 | 17.98 | 19 | 18229 | 4498 | 63466276 |
Pneumonia | 33.20 | 17.98 | 50 | 18198 | 456717 | 63014057 |
Swelling | 33.14 | 17.98 | 19 | 18229 | 275359 | 63195415 |
Viral load decreased | 33.08 | 17.98 | 6 | 18242 | 25 | 63470749 |
Melanoderma | 31.31 | 17.98 | 8 | 18240 | 198 | 63470576 |
Autoimmune hepatitis | 31.00 | 17.98 | 23 | 18225 | 8487 | 63462287 |
Drug reaction with eosinophilia and systemic symptoms | 30.67 | 17.98 | 43 | 18205 | 33793 | 63436981 |
Hepatitis D | 30.59 | 17.98 | 6 | 18242 | 41 | 63470733 |
Cough | 30.13 | 17.98 | 24 | 18224 | 292719 | 63178055 |
Umbilical cord abnormality | 29.80 | 17.98 | 10 | 18238 | 653 | 63470121 |
Discomfort | 29.67 | 17.98 | 6 | 18242 | 167368 | 63303406 |
Congenital pulmonary valve disorder | 29.23 | 17.98 | 6 | 18242 | 53 | 63470721 |
Stomatitis | 29.15 | 17.98 | 3 | 18245 | 138722 | 63332052 |
Rickets | 28.74 | 17.98 | 6 | 18242 | 58 | 63470716 |
Hepatitis A | 28.51 | 17.98 | 9 | 18239 | 484 | 63470290 |
Sudden infant death syndrome | 28.10 | 17.98 | 8 | 18240 | 301 | 63470473 |
Blood creatine phosphokinase increased | 28.07 | 17.98 | 39 | 18209 | 30391 | 63440383 |
Constipation | 27.81 | 17.98 | 15 | 18233 | 224928 | 63245846 |
Polydactyly | 27.80 | 17.98 | 8 | 18240 | 313 | 63470461 |
Condition aggravated | 27.35 | 17.98 | 46 | 18202 | 402171 | 63068603 |
Oesophageal candidiasis | 26.89 | 17.98 | 18 | 18230 | 5645 | 63465129 |
Eyelid oedema | 26.78 | 17.98 | 23 | 18225 | 10456 | 63460318 |
Renal impairment | 26.43 | 17.98 | 70 | 18178 | 88285 | 63382489 |
Foetal cardiac disorder | 26.20 | 17.98 | 5 | 18243 | 29 | 63470745 |
Nephrogenic diabetes insipidus | 26.19 | 17.98 | 10 | 18238 | 949 | 63469825 |
Hepatic failure | 26.12 | 17.98 | 41 | 18207 | 35615 | 63435159 |
Headache | 26.11 | 17.98 | 94 | 18154 | 633147 | 62837627 |
Lipohypertrophy | 25.86 | 17.98 | 9 | 18239 | 656 | 63470118 |
HIV test positive | 25.64 | 17.98 | 5 | 18243 | 33 | 63470741 |
Small for dates baby | 25.58 | 17.98 | 15 | 18233 | 3736 | 63467038 |
Hydrocephalus | 25.54 | 17.98 | 17 | 18231 | 5283 | 63465491 |
Abortion infected | 25.39 | 17.98 | 5 | 18243 | 35 | 63470739 |
Vaginal ulceration | 25.38 | 17.98 | 8 | 18240 | 428 | 63470346 |
Portal hypertension | 25.33 | 17.98 | 15 | 18233 | 3804 | 63466970 |
Albuminuria | 25.32 | 17.98 | 7 | 18241 | 236 | 63470538 |
Blood bilirubin increased | 24.87 | 17.98 | 41 | 18207 | 37099 | 63433675 |
Gamma-glutamyltransferase increased | 24.75 | 17.98 | 39 | 18209 | 33992 | 63436782 |
Benign hydatidiform mole | 24.70 | 17.98 | 6 | 18242 | 120 | 63470654 |
Cholestasis | 24.62 | 17.98 | 36 | 18212 | 29398 | 63441376 |
Mitochondrial toxicity | 24.61 | 17.98 | 8 | 18240 | 473 | 63470301 |
Injection site pain | 24.41 | 17.98 | 4 | 18244 | 129796 | 63340978 |
Type III hyperlipidaemia | 24.23 | 17.98 | 4 | 18244 | 8 | 63470766 |
Congenital knee dislocation | 24.23 | 17.98 | 4 | 18244 | 8 | 63470766 |
HIV-associated neurocognitive disorder | 24.16 | 17.98 | 6 | 18242 | 132 | 63470642 |
Neonatal respiratory arrest | 23.71 | 17.98 | 5 | 18243 | 51 | 63470723 |
Hepatotoxicity | 23.62 | 17.98 | 40 | 18208 | 37001 | 63433773 |
Trisomy 18 | 23.46 | 17.98 | 6 | 18242 | 149 | 63470625 |
Congenital genital malformation | 23.43 | 17.98 | 6 | 18242 | 150 | 63470624 |
Ocular icterus | 23.31 | 17.98 | 14 | 18234 | 3642 | 63467132 |
Arthropathy | 23.22 | 17.98 | 20 | 18228 | 234772 | 63236002 |
Coarctation of the aorta | 23.15 | 17.98 | 8 | 18240 | 571 | 63470203 |
Cloacal exstrophy | 23.06 | 17.98 | 6 | 18242 | 160 | 63470614 |
Chronic papillomatous dermatitis | 22.89 | 17.98 | 5 | 18243 | 61 | 63470713 |
Product use issue | 22.78 | 17.98 | 18 | 18230 | 220502 | 63250272 |
Caudal regression syndrome | 22.67 | 17.98 | 6 | 18242 | 171 | 63470603 |
Ectopic kidney | 22.60 | 17.98 | 5 | 18243 | 65 | 63470709 |
Nephrolithiasis | 22.47 | 17.98 | 42 | 18206 | 41942 | 63428832 |
Rash | 22.47 | 17.98 | 253 | 17995 | 560618 | 62910156 |
Blood bilirubin unconjugated increased | 22.20 | 17.98 | 7 | 18241 | 375 | 63470399 |
ACTH stimulation test abnormal | 22.19 | 17.98 | 4 | 18244 | 16 | 63470758 |
Trisomy 21 | 21.97 | 17.98 | 7 | 18241 | 388 | 63470386 |
Hepatic cirrhosis | 21.78 | 17.98 | 31 | 18217 | 24703 | 63446071 |
Asthma | 21.73 | 17.98 | 5 | 18243 | 127556 | 63343218 |
Mental disability | 21.40 | 17.98 | 5 | 18243 | 84 | 63470690 |
Chronic kidney disease | 21.35 | 17.98 | 43 | 18205 | 45355 | 63425419 |
Feeling abnormal | 21.30 | 17.98 | 8 | 18240 | 148384 | 63322390 |
Blood pressure increased | 21.23 | 17.98 | 10 | 18238 | 162052 | 63308722 |
Pulmonary embolism | 21.06 | 17.98 | 4 | 18244 | 116680 | 63354094 |
Atrial fibrillation | 21.04 | 17.98 | 4 | 18244 | 116632 | 63354142 |
Twin pregnancy | 20.90 | 17.98 | 9 | 18239 | 1164 | 63469610 |
Blood alkaline phosphatase increased | 20.57 | 17.98 | 41 | 18207 | 42926 | 63427848 |
Dermatitis exfoliative | 20.44 | 17.98 | 15 | 18233 | 5444 | 63465330 |
COVID-19 | 20.15 | 17.98 | 4 | 18244 | 113099 | 63357675 |
Thymus hypoplasia | 20.07 | 17.98 | 4 | 18244 | 30 | 63470744 |
Alopecia | 19.94 | 17.98 | 42 | 18206 | 337494 | 63133280 |
Pulmonary valve sclerosis | 19.62 | 17.98 | 4 | 18244 | 34 | 63470740 |
Eosinophilia | 19.27 | 17.98 | 28 | 18220 | 22728 | 63448046 |
Lower respiratory tract infection | 19.21 | 17.98 | 7 | 18241 | 132300 | 63338474 |
Tubulointerstitial nephritis | 19.10 | 17.98 | 26 | 18222 | 19877 | 63450897 |
CSF test abnormal | 19.05 | 17.98 | 6 | 18242 | 320 | 63470454 |
Influenza | 19.05 | 17.98 | 4 | 18244 | 108718 | 63362056 |
Amniorrhoea | 19.01 | 17.98 | 5 | 18243 | 139 | 63470635 |
Arthritis | 18.86 | 17.98 | 5 | 18243 | 115916 | 63354858 |
Gait disturbance | 18.85 | 17.98 | 15 | 18233 | 183163 | 63287611 |
Generalised anxiety disorder | 18.80 | 17.98 | 10 | 18238 | 2064 | 63468710 |
Face oedema | 18.79 | 17.98 | 26 | 18222 | 20186 | 63450588 |
Hypouricaemia | 18.65 | 17.98 | 5 | 18243 | 150 | 63470624 |
Blister | 18.62 | 17.98 | 7 | 18241 | 129807 | 63340967 |
Pregnancy on oral contraceptive | 18.62 | 17.98 | 8 | 18240 | 1029 | 63469745 |
Bladder agenesis | 18.52 | 17.98 | 5 | 18243 | 154 | 63470620 |
Chronic hepatitis B | 18.52 | 17.98 | 6 | 18242 | 351 | 63470423 |
Genitalia external ambiguous | 18.31 | 17.98 | 5 | 18243 | 161 | 63470613 |
Glycocholic acid increased | 18.17 | 17.98 | 3 | 18245 | 6 | 63470768 |
Carbon dioxide combining power abnormal | 18.17 | 17.98 | 3 | 18245 | 6 | 63470768 |
Growth hormone-producing pituitary tumour | 18.17 | 17.98 | 3 | 18245 | 6 | 63470768 |
Product use in unapproved indication | 18.01 | 17.98 | 15 | 18233 | 179065 | 63291709 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Virologic failure | 1033.24 | 12.61 | 295 | 33058 | 3185 | 34920393 |
Immune reconstitution inflammatory syndrome | 926.28 | 12.61 | 339 | 33014 | 8420 | 34915158 |
Viral mutation identified | 879.55 | 12.61 | 251 | 33102 | 2703 | 34920875 |
Fanconi syndrome acquired | 832.81 | 12.61 | 221 | 33132 | 1770 | 34921808 |
Pathogen resistance | 687.77 | 12.61 | 279 | 33074 | 9203 | 34914375 |
Lipodystrophy acquired | 582.04 | 12.61 | 188 | 33165 | 3156 | 34920422 |
Mitochondrial toxicity | 462.61 | 12.61 | 150 | 33203 | 2549 | 34921029 |
Renal tubular disorder | 440.34 | 12.61 | 166 | 33187 | 4477 | 34919101 |
Osteoporosis | 425.26 | 12.61 | 218 | 33135 | 12450 | 34911128 |
Viral load increased | 403.04 | 12.61 | 133 | 33220 | 2394 | 34921184 |
Drug resistance | 349.16 | 12.61 | 248 | 33105 | 25679 | 34897899 |
Fanconi syndrome | 333.46 | 12.61 | 105 | 33248 | 1615 | 34921963 |
Hepatitis B | 323.58 | 12.61 | 143 | 33210 | 5840 | 34917738 |
Foetal exposure during pregnancy | 314.62 | 12.61 | 273 | 33080 | 37828 | 34885750 |
Eyelid ptosis | 309.21 | 12.61 | 137 | 33216 | 5629 | 34917949 |
Blood HIV RNA increased | 280.30 | 12.61 | 85 | 33268 | 1145 | 34922433 |
Hypophosphataemia | 243.57 | 12.61 | 144 | 33209 | 10882 | 34912696 |
Progressive external ophthalmoplegia | 238.77 | 12.61 | 78 | 33275 | 1357 | 34922221 |
Genotype drug resistance test positive | 230.72 | 12.61 | 72 | 33281 | 1073 | 34922505 |
Nephropathy toxic | 223.49 | 12.61 | 143 | 33210 | 12445 | 34911133 |
Acquired gene mutation | 187.08 | 12.61 | 64 | 33289 | 1291 | 34922287 |
Glycosuria | 184.84 | 12.61 | 62 | 33291 | 1175 | 34922403 |
Osteomalacia | 177.82 | 12.61 | 56 | 33297 | 861 | 34922717 |
Proteinuria | 175.18 | 12.61 | 144 | 33209 | 18498 | 34905080 |
Diplopia | 172.88 | 12.61 | 137 | 33216 | 16706 | 34906872 |
Blood phosphorus decreased | 168.66 | 12.61 | 75 | 33278 | 3106 | 34920472 |
Blood creatinine increased | 162.62 | 12.61 | 310 | 33043 | 94666 | 34828912 |
Renal tubular dysfunction | 161.94 | 12.61 | 44 | 33309 | 388 | 34923190 |
CD4 lymphocytes decreased | 156.92 | 12.61 | 60 | 33293 | 1681 | 34921897 |
Hepatitis B DNA increased | 154.67 | 12.61 | 45 | 33308 | 520 | 34923058 |
Osteonecrosis | 148.30 | 12.61 | 119 | 33234 | 14771 | 34908807 |
Hepatitis B reactivation | 133.51 | 12.61 | 68 | 33285 | 3823 | 34919755 |
Renal colic | 129.42 | 12.61 | 53 | 33300 | 1786 | 34921792 |
Renal failure | 125.65 | 12.61 | 339 | 33014 | 130218 | 34793360 |
Treatment failure | 116.15 | 12.61 | 180 | 33173 | 46517 | 34877061 |
Renal tubular acidosis | 114.42 | 12.61 | 52 | 33301 | 2267 | 34921311 |
Hepatic failure | 107.49 | 12.61 | 148 | 33205 | 34383 | 34889195 |
Exposure during pregnancy | 101.07 | 12.61 | 77 | 33276 | 8857 | 34914721 |
Jaundice | 99.76 | 12.61 | 137 | 33216 | 31745 | 34891833 |
Renal impairment | 97.54 | 12.61 | 252 | 33101 | 94261 | 34829317 |
HIV-associated neurocognitive disorder | 96.84 | 12.61 | 28 | 33325 | 316 | 34923262 |
Pneumonia | 91.43 | 12.61 | 128 | 33225 | 362499 | 34561079 |
Osteopenia | 90.81 | 12.61 | 57 | 33296 | 4792 | 34918786 |
Renal tubular necrosis | 82.97 | 12.61 | 88 | 33265 | 15592 | 34907986 |
Alanine aminotransferase increased | 82.86 | 12.61 | 215 | 33138 | 80600 | 34842978 |
Volvulus | 81.80 | 12.61 | 37 | 33316 | 1595 | 34921983 |
Nephrolithiasis | 81.16 | 12.61 | 121 | 33232 | 30212 | 34893366 |
Hepatic cirrhosis | 79.17 | 12.61 | 90 | 33263 | 17224 | 34906354 |
Acquired immunodeficiency syndrome | 77.54 | 12.61 | 26 | 33327 | 492 | 34923086 |
Multiple-drug resistance | 77.17 | 12.61 | 53 | 33300 | 5186 | 34918392 |
Hepatitis B DNA assay positive | 76.07 | 12.61 | 17 | 33336 | 58 | 34923520 |
Osteoporotic fracture | 75.15 | 12.61 | 31 | 33322 | 1064 | 34922514 |
Acute HIV infection | 71.28 | 12.61 | 16 | 33337 | 56 | 34923522 |
Chronic kidney disease | 70.99 | 12.61 | 135 | 33218 | 41075 | 34882503 |
Kaposi's sarcoma | 70.95 | 12.61 | 28 | 33325 | 855 | 34922723 |
Dyspnoea | 70.57 | 12.61 | 160 | 33193 | 376622 | 34546956 |
Hepatocellular carcinoma | 70.50 | 12.61 | 58 | 33295 | 7451 | 34916127 |
Lactic acidosis | 70.16 | 12.61 | 122 | 33231 | 34650 | 34888928 |
Aspartate aminotransferase increased | 70.15 | 12.61 | 181 | 33172 | 67602 | 34855976 |
Hypotension | 67.78 | 12.61 | 67 | 33286 | 221582 | 34701996 |
Premature baby | 66.95 | 12.61 | 88 | 33265 | 19545 | 34904033 |
Treatment noncompliance | 65.24 | 12.61 | 105 | 33248 | 27995 | 34895583 |
Hepatic cytolysis | 64.00 | 12.61 | 74 | 33279 | 14422 | 34909156 |
Brain stem stroke | 63.59 | 12.61 | 20 | 33333 | 306 | 34923272 |
Hepatitis | 63.43 | 12.61 | 95 | 33258 | 23809 | 34899769 |
Ophthalmoplegia | 62.66 | 12.61 | 32 | 33321 | 1808 | 34921770 |
Lipoatrophy | 62.30 | 12.61 | 22 | 33331 | 489 | 34923089 |
Acute kidney injury | 61.76 | 12.61 | 499 | 32854 | 304489 | 34619089 |
Drug interaction | 61.49 | 12.61 | 397 | 32956 | 225549 | 34698029 |
Febrile neutropenia | 61.18 | 12.61 | 27 | 33326 | 136822 | 34786756 |
Glomerular filtration rate decreased | 60.32 | 12.61 | 68 | 33285 | 12893 | 34910685 |
Mitochondrial cytopathy | 60.21 | 12.61 | 17 | 33336 | 175 | 34923403 |
Gene mutation | 58.39 | 12.61 | 28 | 33325 | 1380 | 34922198 |
Death | 57.35 | 12.61 | 192 | 33161 | 397857 | 34525721 |
Malignant neoplasm progression | 57.28 | 12.61 | 8 | 33345 | 88038 | 34835540 |
HIV infection | 56.66 | 12.61 | 27 | 33326 | 1312 | 34922266 |
Psychiatric decompensation | 56.19 | 12.61 | 35 | 33318 | 2902 | 34920676 |
Off label use | 56.02 | 12.61 | 209 | 33144 | 419315 | 34504263 |
Trisomy 21 | 55.68 | 12.61 | 21 | 33332 | 566 | 34923012 |
Portal hypertension | 54.94 | 12.61 | 39 | 33314 | 4023 | 34919555 |
Depressive symptom | 54.52 | 12.61 | 34 | 33319 | 2825 | 34920753 |
Tearfulness | 54.12 | 12.61 | 33 | 33320 | 2634 | 34920944 |
Creatinine renal clearance decreased | 51.69 | 12.61 | 35 | 33318 | 3346 | 34920232 |
Depression suicidal | 50.85 | 12.61 | 31 | 33322 | 2474 | 34921104 |
Syphilis | 50.24 | 12.61 | 18 | 33335 | 418 | 34923160 |
Anal cancer | 49.18 | 12.61 | 18 | 33335 | 445 | 34923133 |
Fall | 48.63 | 12.61 | 74 | 33279 | 202811 | 34720767 |
Varices oesophageal | 48.37 | 12.61 | 35 | 33318 | 3720 | 34919858 |
Atrial fibrillation | 47.50 | 12.61 | 29 | 33324 | 122364 | 34801214 |
Cytomegalovirus chorioretinitis | 47.48 | 12.61 | 34 | 33319 | 3555 | 34920023 |
Beta 2 microglobulin urine increased | 47.23 | 12.61 | 12 | 33341 | 79 | 34923499 |
Product dose omission issue | 46.97 | 12.61 | 28 | 33325 | 119683 | 34803895 |
CSF HIV escape syndrome | 46.26 | 12.61 | 14 | 33339 | 187 | 34923391 |
Ultrasound antenatal screen | 45.97 | 12.61 | 18 | 33335 | 538 | 34923040 |
Disease progression | 45.71 | 12.61 | 23 | 33330 | 108054 | 34815524 |
Drug abuse | 45.15 | 12.61 | 19 | 33334 | 99077 | 34824501 |
Hyperbilirubinaemia | 44.77 | 12.61 | 67 | 33286 | 16776 | 34906802 |
Congenital umbilical hernia | 44.48 | 12.61 | 15 | 33338 | 289 | 34923289 |
Cleft lip and palate | 43.57 | 12.61 | 20 | 33333 | 892 | 34922686 |
Constipation | 43.46 | 12.61 | 40 | 33313 | 136942 | 34786636 |
Toxicity to various agents | 43.44 | 12.61 | 78 | 33275 | 200284 | 34723294 |
Peripheral swelling | 43.21 | 12.61 | 10 | 33343 | 76531 | 34847047 |
Completed suicide | 42.87 | 12.61 | 20 | 33333 | 98148 | 34825430 |
Blood phosphorus abnormal | 42.63 | 12.61 | 12 | 33341 | 122 | 34923456 |
Blood bilirubin increased | 42.45 | 12.61 | 105 | 33248 | 38191 | 34885387 |
Blood lactic acid increased | 41.46 | 12.61 | 41 | 33312 | 6687 | 34916891 |
Psychomotor skills impaired | 40.55 | 12.61 | 32 | 33321 | 3874 | 34919704 |
Trisomy 18 | 40.29 | 12.61 | 18 | 33335 | 753 | 34922825 |
Blood pressure increased | 39.96 | 12.61 | 17 | 33336 | 88085 | 34835493 |
Blood creatine phosphokinase increased | 39.58 | 12.61 | 113 | 33240 | 44744 | 34878834 |
Lymphoma | 39.48 | 12.61 | 54 | 33299 | 12453 | 34911125 |
Hypophosphataemic osteomalacia | 37.89 | 12.61 | 11 | 33342 | 126 | 34923452 |
Brachydactyly | 37.83 | 12.61 | 12 | 33341 | 189 | 34923389 |
Infusion related reaction | 36.50 | 12.61 | 4 | 33349 | 53053 | 34870525 |
Congenital hearing disorder | 36.14 | 12.61 | 10 | 33343 | 95 | 34923483 |
Hepatic cancer | 36.11 | 12.61 | 42 | 33311 | 8233 | 34915345 |
Abnormal dreams | 35.67 | 12.61 | 40 | 33313 | 7538 | 34916040 |
Hydrops foetalis | 35.22 | 12.61 | 17 | 33336 | 850 | 34922728 |
COVID-19 | 35.11 | 12.61 | 15 | 33338 | 77535 | 34846043 |
Hepatitis C | 34.97 | 12.61 | 45 | 33308 | 9785 | 34913793 |
Hyperphosphaturia | 34.01 | 12.61 | 9 | 33344 | 71 | 34923507 |
Hepatic steatosis | 33.91 | 12.61 | 62 | 33291 | 18300 | 34905278 |
Fatigue | 33.47 | 12.61 | 212 | 33141 | 370441 | 34553137 |
Oesophageal atresia | 33.44 | 12.61 | 14 | 33339 | 499 | 34923079 |
Oesophageal candidiasis | 33.23 | 12.61 | 30 | 33323 | 4366 | 34919212 |
Congenital anomaly | 32.87 | 12.61 | 19 | 33334 | 1374 | 34922204 |
Nephropathy | 32.71 | 12.61 | 34 | 33319 | 5883 | 34917695 |
HIV wasting syndrome | 32.57 | 12.61 | 9 | 33344 | 85 | 34923493 |
Polydactyly | 32.56 | 12.61 | 18 | 33335 | 1195 | 34922383 |
Lymphadenopathy | 32.56 | 12.61 | 79 | 33274 | 28384 | 34895194 |
Nasopharyngitis | 32.53 | 12.61 | 13 | 33340 | 69955 | 34853623 |
Megakaryocytes increased | 32.41 | 12.61 | 8 | 33345 | 46 | 34923532 |
Progressive multifocal leukoencephalopathy | 32.10 | 12.61 | 43 | 33310 | 9721 | 34913857 |
Hemivertebra | 32.04 | 12.61 | 10 | 33343 | 149 | 34923429 |
Blood alkaline phosphatase increased | 31.96 | 12.61 | 83 | 33270 | 31092 | 34892486 |
Joint swelling | 31.54 | 12.61 | 9 | 33344 | 59881 | 34863697 |
Anogenital warts | 31.40 | 12.61 | 14 | 33339 | 583 | 34922995 |
Liver disorder | 30.95 | 12.61 | 85 | 33268 | 32912 | 34890666 |
Hepatosplenomegaly | 30.63 | 12.61 | 28 | 33325 | 4141 | 34919437 |
Cardiac failure congestive | 30.56 | 12.61 | 21 | 33332 | 83249 | 34840329 |
Nodular regenerative hyperplasia | 30.48 | 12.61 | 16 | 33337 | 957 | 34922621 |
Sepsis | 30.03 | 12.61 | 72 | 33281 | 166489 | 34757089 |
Pain | 29.86 | 12.61 | 98 | 33255 | 204577 | 34719001 |
Maternal drugs affecting foetus | 29.85 | 12.61 | 27 | 33326 | 3938 | 34919640 |
Paranoia | 29.25 | 12.61 | 46 | 33307 | 12022 | 34911556 |
Neurosyphilis | 28.86 | 12.61 | 7 | 33346 | 37 | 34923541 |
Ocular icterus | 28.78 | 12.61 | 23 | 33330 | 2834 | 34920744 |
Laryngomalacia | 28.34 | 12.61 | 11 | 33342 | 321 | 34923257 |
Dysphagia | 28.08 | 12.61 | 126 | 33227 | 62255 | 34861323 |
Tubulointerstitial nephritis | 28.05 | 12.61 | 62 | 33291 | 20962 | 34902616 |
Hepatorenal syndrome | 28.01 | 12.61 | 22 | 33331 | 2644 | 34920934 |
HIV test positive | 27.74 | 12.61 | 9 | 33344 | 153 | 34923425 |
Bone pain | 27.59 | 12.61 | 61 | 33292 | 20625 | 34902953 |
Haemophilic arthropathy | 27.52 | 12.61 | 9 | 33344 | 157 | 34923421 |
Pulmonary tuberculosis | 27.51 | 12.61 | 28 | 33325 | 4726 | 34918852 |
Hypertriglyceridaemia | 27.46 | 12.61 | 37 | 33316 | 8411 | 34915167 |
Porphyria non-acute | 27.44 | 12.61 | 12 | 33341 | 477 | 34923101 |
Product use issue | 27.40 | 12.61 | 13 | 33340 | 63203 | 34860375 |
Birth mark | 27.31 | 12.61 | 9 | 33344 | 161 | 34923417 |
Pulmonary oedema | 27.24 | 12.61 | 6 | 33347 | 47523 | 34876055 |
Blood antidiuretic hormone increased | 27.18 | 12.61 | 7 | 33346 | 49 | 34923529 |
Plasma cell myeloma | 26.91 | 12.61 | 4 | 33349 | 42033 | 34881545 |
Diaphragmatic hernia | 26.85 | 12.61 | 10 | 33343 | 260 | 34923318 |
Nervous system disorder | 26.72 | 12.61 | 49 | 33304 | 14494 | 34909084 |
Oxygen saturation decreased | 26.70 | 12.61 | 9 | 33344 | 53809 | 34869769 |
Hepatic fibrosis | 26.41 | 12.61 | 27 | 33326 | 4580 | 34918998 |
Hodgkin's disease | 26.22 | 12.61 | 14 | 33339 | 867 | 34922711 |
Hydrocele | 25.85 | 12.61 | 19 | 33334 | 2068 | 34921510 |
Back pain | 25.83 | 12.61 | 48 | 33305 | 121741 | 34801837 |
Cerebellar syndrome | 25.73 | 12.61 | 20 | 33333 | 2368 | 34921210 |
Developmental hip dysplasia | 25.66 | 12.61 | 10 | 33343 | 295 | 34923283 |
Meningomyelocele | 25.53 | 12.61 | 9 | 33344 | 199 | 34923379 |
Influenza | 25.18 | 12.61 | 8 | 33345 | 49658 | 34873920 |
CSF virus identified | 25.01 | 12.61 | 6 | 33347 | 30 | 34923548 |
Talipes | 24.94 | 12.61 | 18 | 33335 | 1905 | 34921673 |
Wheezing | 24.19 | 12.61 | 5 | 33348 | 41397 | 34882181 |
Bradycardia | 23.92 | 12.61 | 22 | 33331 | 75396 | 34848182 |
Hepatic encephalopathy | 23.91 | 12.61 | 47 | 33306 | 14638 | 34908940 |
Epistaxis | 23.72 | 12.61 | 13 | 33340 | 58238 | 34865340 |
Protein urine present | 23.59 | 12.61 | 27 | 33326 | 5201 | 34918377 |
Retroviral rebound syndrome | 23.39 | 12.61 | 5 | 33348 | 13 | 34923565 |
Liver function test abnormal | 23.36 | 12.61 | 74 | 33279 | 31000 | 34892578 |
Atypical mycobacterial infection | 23.28 | 12.61 | 13 | 33340 | 880 | 34922698 |
Dyslipidaemia | 23.14 | 12.61 | 32 | 33321 | 7456 | 34916122 |
Abortion spontaneous | 23.04 | 12.61 | 10 | 33343 | 390 | 34923188 |
Acute hepatitis C | 22.96 | 12.61 | 7 | 33346 | 96 | 34923482 |
Therapeutic product effect decreased | 22.96 | 12.61 | 3 | 33350 | 34740 | 34888838 |
Infection | 22.88 | 12.61 | 32 | 33321 | 90883 | 34832695 |
Prostate cancer | 22.73 | 12.61 | 5 | 33348 | 39644 | 34883934 |
Cachexia | 22.64 | 12.61 | 31 | 33322 | 7155 | 34916423 |
Hepatitis B e antigen positive | 22.60 | 12.61 | 6 | 33347 | 48 | 34923530 |
Gamma-glutamyltransferase increased | 22.33 | 12.61 | 70 | 33283 | 29161 | 34894417 |
Pneumonitis | 22.21 | 12.61 | 3 | 33350 | 33875 | 34889703 |
Injection site pain | 22.19 | 12.61 | 5 | 33348 | 39000 | 34884578 |
Dialysis | 22.17 | 12.61 | 39 | 33314 | 11169 | 34912409 |
Cerebral toxoplasmosis | 22.07 | 12.61 | 16 | 33337 | 1705 | 34921873 |
Cryptorchism | 21.79 | 12.61 | 17 | 33336 | 2024 | 34921554 |
AIDS related complication | 21.75 | 12.61 | 5 | 33348 | 20 | 34923558 |
Burkitt's lymphoma | 21.74 | 12.61 | 7 | 33346 | 116 | 34923462 |
Inappropriate schedule of product administration | 21.19 | 12.61 | 17 | 33336 | 62279 | 34861299 |
Musculoskeletal stiffness | 21.17 | 12.61 | 9 | 33344 | 46671 | 34876907 |
Cough | 21.11 | 12.61 | 73 | 33280 | 150067 | 34773511 |
Secondary syphilis | 21.06 | 12.61 | 6 | 33347 | 64 | 34923514 |
Oesophageal varices haemorrhage | 20.94 | 12.61 | 20 | 33333 | 3126 | 34920452 |
Anaphylactic reaction | 20.84 | 12.61 | 3 | 33350 | 32298 | 34891280 |
Polydipsia | 20.75 | 12.61 | 22 | 33331 | 3893 | 34919685 |
Hyperhidrosis | 20.73 | 12.61 | 25 | 33328 | 75667 | 34847911 |
Bone density decreased | 20.44 | 12.61 | 16 | 33337 | 1913 | 34921665 |
Asymptomatic viral hepatitis | 20.37 | 12.61 | 5 | 33348 | 28 | 34923550 |
Heart rate decreased | 20.36 | 12.61 | 3 | 33350 | 31742 | 34891836 |
Blood pressure decreased | 20.25 | 12.61 | 12 | 33341 | 51503 | 34872075 |
Cardiac failure | 20.21 | 12.61 | 35 | 33318 | 91213 | 34832365 |
Creatinine renal clearance abnormal | 20.10 | 12.61 | 8 | 33345 | 250 | 34923328 |
Myalgia | 19.92 | 12.61 | 143 | 33210 | 83967 | 34839611 |
Polyuria | 19.84 | 12.61 | 32 | 33321 | 8542 | 34915036 |
Chest discomfort | 19.67 | 12.61 | 14 | 33339 | 54516 | 34869062 |
End stage AIDS | 19.54 | 12.61 | 5 | 33348 | 34 | 34923544 |
Haematochezia | 19.51 | 12.61 | 10 | 33343 | 46524 | 34877054 |
Syncope | 19.42 | 12.61 | 36 | 33317 | 91415 | 34832163 |
Supernumerary nipple | 19.06 | 12.61 | 5 | 33348 | 38 | 34923540 |
Blood bicarbonate decreased | 18.85 | 12.61 | 17 | 33336 | 2470 | 34921108 |
Haemodialysis | 18.75 | 12.61 | 35 | 33318 | 10491 | 34913087 |
Polyneuropathy chronic | 18.72 | 12.61 | 5 | 33348 | 41 | 34923537 |
Immune reconstitution inflammatory syndrome associated tuberculosis | 18.66 | 12.61 | 9 | 33344 | 449 | 34923129 |
Rhabdomyolysis | 18.59 | 12.61 | 120 | 33233 | 68043 | 34855535 |
Cardiac arrest | 18.58 | 12.61 | 40 | 33313 | 96119 | 34827459 |
Interstitial lung disease | 18.48 | 12.61 | 21 | 33332 | 65261 | 34858317 |
Protrusion tongue | 18.44 | 12.61 | 7 | 33346 | 192 | 34923386 |
Kidney fibrosis | 18.42 | 12.61 | 16 | 33337 | 2212 | 34921366 |
Psychotic disorder | 18.17 | 12.61 | 58 | 33295 | 24394 | 34899184 |
HIV associated nephropathy | 18.13 | 12.61 | 8 | 33345 | 325 | 34923253 |
Portal fibrosis | 18.13 | 12.61 | 8 | 33345 | 325 | 34923253 |
Lower respiratory tract infection | 18.11 | 12.61 | 4 | 33349 | 31633 | 34891945 |
C-reactive protein increased | 18.10 | 12.61 | 15 | 33338 | 54083 | 34869495 |
Rash maculo-papular | 18.06 | 12.61 | 64 | 33289 | 28387 | 34895191 |
Blood triglycerides increased | 18.04 | 12.61 | 41 | 33312 | 14118 | 34909460 |
Hepatic function abnormal | 18.04 | 12.61 | 87 | 33266 | 44276 | 34879302 |
Perihepatic discomfort | 17.87 | 12.61 | 3 | 33350 | 0 | 34923578 |
Pneumocystis jirovecii pneumonia | 17.71 | 12.61 | 50 | 33303 | 19660 | 34903918 |
CD4 lymphocytes increased | 17.58 | 12.61 | 7 | 33346 | 219 | 34923359 |
Lymphocytic infiltration | 17.53 | 12.61 | 10 | 33343 | 705 | 34922873 |
Malaise | 17.37 | 12.61 | 105 | 33248 | 185720 | 34737858 |
International normalised ratio increased | 17.27 | 12.61 | 12 | 33341 | 47315 | 34876263 |
Small for dates baby | 17.25 | 12.61 | 20 | 33333 | 3907 | 34919671 |
Pathological fracture | 17.04 | 12.61 | 21 | 33332 | 4370 | 34919208 |
Adrenogenital syndrome | 17.01 | 12.61 | 5 | 33348 | 60 | 34923518 |
Viraemia | 17.00 | 12.61 | 12 | 33341 | 1226 | 34922352 |
Ventricular septal defect | 16.94 | 12.61 | 20 | 33333 | 3981 | 34919597 |
Viral load | 16.94 | 12.61 | 5 | 33348 | 61 | 34923517 |
Musculoskeletal toxicity | 16.92 | 12.61 | 6 | 33347 | 135 | 34923443 |
Mycobacterium avium complex infection | 16.78 | 12.61 | 16 | 33337 | 2495 | 34921083 |
Congenital naevus | 16.68 | 12.61 | 4 | 33349 | 20 | 34923558 |
Tachycardia | 16.60 | 12.61 | 35 | 33318 | 84737 | 34838841 |
Incorrect dose administered | 16.55 | 12.61 | 9 | 33344 | 40506 | 34883072 |
Pleural effusion | 16.53 | 12.61 | 33 | 33320 | 81513 | 34842065 |
Cushing's syndrome | 16.48 | 12.61 | 8 | 33345 | 405 | 34923173 |
Pancreatitis | 16.34 | 12.61 | 77 | 33276 | 38814 | 34884764 |
White matter lesion | 16.33 | 12.61 | 10 | 33343 | 804 | 34922774 |
Glucose urine present | 16.22 | 12.61 | 11 | 33342 | 1054 | 34922524 |
Lipohypertrophy | 16.18 | 12.61 | 7 | 33346 | 271 | 34923307 |
Hepatic enzyme increased | 16.15 | 12.61 | 77 | 33276 | 39003 | 34884575 |
Pneumonia aspiration | 16.14 | 12.61 | 10 | 33343 | 41893 | 34881685 |
Congenital tuberculosis | 16.06 | 12.61 | 4 | 33349 | 24 | 34923554 |
Pulmonary embolism | 15.99 | 12.61 | 39 | 33314 | 89707 | 34833871 |
Neck deformity | 15.93 | 12.61 | 5 | 33348 | 76 | 34923502 |
Antiviral drug level below therapeutic | 15.79 | 12.61 | 3 | 33350 | 3 | 34923575 |
Congenital gastric anomaly | 15.79 | 12.61 | 3 | 33350 | 3 | 34923575 |
Calculus urinary | 15.63 | 12.61 | 12 | 33341 | 1395 | 34922183 |
White blood cell count increased | 15.60 | 12.61 | 10 | 33343 | 41141 | 34882437 |
CSF glucose decreased | 15.53 | 12.61 | 4 | 33349 | 28 | 34923550 |
Low set ears | 15.52 | 12.61 | 8 | 33345 | 461 | 34923117 |
Muscle spasms | 15.51 | 12.61 | 30 | 33323 | 74971 | 34848607 |
Haemoglobin decreased | 15.48 | 12.61 | 61 | 33292 | 120711 | 34802867 |
Meningitis cryptococcal | 15.46 | 12.61 | 15 | 33338 | 2389 | 34921189 |
Disseminated mycobacterium avium complex infection | 15.46 | 12.61 | 5 | 33348 | 84 | 34923494 |
Hepatomegaly | 15.41 | 12.61 | 32 | 33321 | 10364 | 34913214 |
Micrognathia | 15.36 | 12.61 | 7 | 33346 | 307 | 34923271 |
Gastrointestinal haemorrhage | 15.33 | 12.61 | 39 | 33314 | 88438 | 34835140 |
Meningitis tuberculous | 15.26 | 12.61 | 9 | 33344 | 676 | 34922902 |
Amyotrophy | 15.23 | 12.61 | 8 | 33345 | 479 | 34923099 |
Stress | 15.18 | 12.61 | 5 | 33348 | 30342 | 34893236 |
Mucosal inflammation | 15.18 | 12.61 | 9 | 33344 | 38613 | 34884965 |
Cellulitis | 15.02 | 12.61 | 17 | 33336 | 52934 | 34870644 |
Platelet count decreased | 15.00 | 12.61 | 61 | 33292 | 119656 | 34803922 |
Hepatitis B surface antibody positive | 14.99 | 12.61 | 5 | 33348 | 93 | 34923485 |
Caesarean section | 14.86 | 12.61 | 14 | 33339 | 2150 | 34921428 |
Transient ischaemic attack | 14.81 | 12.61 | 4 | 33349 | 27609 | 34895969 |
Mitochondrial myopathy | 14.74 | 12.61 | 6 | 33347 | 199 | 34923379 |
Chronic obstructive pulmonary disease | 14.66 | 12.61 | 15 | 33338 | 48903 | 34874675 |
Therapeutic product effect incomplete | 14.59 | 12.61 | 16 | 33337 | 50525 | 34873053 |
Laryngeal erythema | 14.58 | 12.61 | 3 | 33350 | 6 | 34923572 |
Neonatal asphyxia | 14.54 | 12.61 | 7 | 33346 | 348 | 34923230 |
Thrombosis | 14.53 | 12.61 | 16 | 33337 | 50442 | 34873136 |
Sinusitis | 14.45 | 12.61 | 11 | 33342 | 41391 | 34882187 |
Hemiparaesthesia | 14.29 | 12.61 | 5 | 33348 | 108 | 34923470 |
Pleocytosis | 14.29 | 12.61 | 8 | 33345 | 544 | 34923034 |
Viral load decreased | 14.27 | 12.61 | 4 | 33349 | 40 | 34923538 |
Suicidal ideation | 14.17 | 12.61 | 76 | 33277 | 40312 | 34883266 |
Cardiogenic shock | 14.01 | 12.61 | 4 | 33349 | 26614 | 34896964 |
CD4 lymphocytes abnormal | 14.01 | 12.61 | 4 | 33349 | 43 | 34923535 |
Drug dependence | 13.99 | 12.61 | 3 | 33350 | 24214 | 34899364 |
Pharyngeal cancer | 13.84 | 12.61 | 4 | 33349 | 45 | 34923533 |
Optic neuritis | 13.72 | 12.61 | 17 | 33336 | 3557 | 34920021 |
VIIIth nerve injury | 13.72 | 12.61 | 3 | 33350 | 9 | 34923569 |
Eagle Barrett syndrome | 13.72 | 12.61 | 3 | 33350 | 9 | 34923569 |
Phosphorus metabolism disorder | 13.72 | 12.61 | 3 | 33350 | 9 | 34923569 |
Vth nerve injury | 13.72 | 12.61 | 3 | 33350 | 9 | 34923569 |
Blood creatinine abnormal | 13.69 | 12.61 | 14 | 33339 | 2376 | 34921202 |
Stevens-Johnson syndrome | 13.65 | 12.61 | 44 | 33309 | 18595 | 34904983 |
Hypospadias | 13.55 | 12.61 | 16 | 33337 | 3185 | 34920393 |
Urine calcium increased | 13.46 | 12.61 | 4 | 33349 | 50 | 34923528 |
Psychomotor retardation | 13.44 | 12.61 | 17 | 33336 | 3633 | 34919945 |
Antiviral drug level above therapeutic | 13.39 | 12.61 | 4 | 33349 | 51 | 34923527 |
Urine phosphorus increased | 13.39 | 12.61 | 4 | 33349 | 51 | 34923527 |
Respiratory arrest | 13.38 | 12.61 | 5 | 33348 | 28038 | 34895540 |
Cortisol decreased | 13.38 | 12.61 | 10 | 33343 | 1117 | 34922461 |
Hypouricaemia | 13.32 | 12.61 | 6 | 33347 | 256 | 34923322 |
Rhinorrhoea | 13.25 | 12.61 | 4 | 33349 | 25664 | 34897914 |
Splenomegaly | 13.24 | 12.61 | 38 | 33315 | 15079 | 34908499 |
Anogenital dysplasia | 13.21 | 12.61 | 5 | 33348 | 136 | 34923442 |
Dizziness | 13.21 | 12.61 | 139 | 33214 | 218382 | 34705196 |
Femoral neck fracture | 13.13 | 12.61 | 16 | 33337 | 3291 | 34920287 |
Upper gastrointestinal haemorrhage | 13.13 | 12.61 | 4 | 33349 | 25514 | 34898064 |
Congenital diaphragmatic hernia | 13.13 | 12.61 | 6 | 33347 | 265 | 34923313 |
Vitamin D deficiency | 13.08 | 12.61 | 23 | 33330 | 6585 | 34916993 |
Somnolence | 13.07 | 12.61 | 58 | 33295 | 111058 | 34812520 |
Seroconversion test positive | 13.05 | 12.61 | 3 | 33350 | 12 | 34923566 |
Cranial nerve palsies multiple | 13.04 | 12.61 | 4 | 33349 | 56 | 34923522 |
Hypersplenism | 13.00 | 12.61 | 7 | 33346 | 441 | 34923137 |
Blood pressure systolic increased | 12.94 | 12.61 | 3 | 33350 | 22949 | 34900629 |
Cytokine release syndrome | 12.88 | 12.61 | 3 | 33350 | 22874 | 34900704 |
Optic nerve cupping | 12.67 | 12.61 | 4 | 33349 | 62 | 34923516 |
Hyperlactacidaemia | 12.65 | 12.61 | 15 | 33338 | 3001 | 34920577 |
Renal disorder | 12.63 | 12.61 | 53 | 33300 | 25427 | 34898151 |
Ureterolithiasis | 12.62 | 12.61 | 13 | 33340 | 2226 | 34921352 |
Delirium | 12.61 | 12.61 | 14 | 33339 | 43977 | 34879601 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Virologic failure | 1151.58 | 13.48 | 288 | 37085 | 3903 | 79703112 |
Immune reconstitution inflammatory syndrome | 1122.30 | 13.48 | 367 | 37006 | 13474 | 79693541 |
Fanconi syndrome acquired | 1058.30 | 13.48 | 247 | 37126 | 2447 | 79704568 |
Abortion spontaneous | 978.62 | 13.48 | 405 | 36968 | 29102 | 79677913 |
Viral mutation identified | 848.37 | 13.48 | 222 | 37151 | 3636 | 79703379 |
Lipodystrophy acquired | 725.51 | 13.48 | 201 | 37172 | 4124 | 79702891 |
Pathogen resistance | 668.81 | 13.48 | 252 | 37121 | 14090 | 79692925 |
Blood HIV RNA increased | 560.83 | 13.48 | 137 | 37236 | 1671 | 79705344 |
Drug resistance | 550.19 | 13.48 | 305 | 37068 | 41908 | 79665107 |
Mitochondrial toxicity | 546.65 | 13.48 | 150 | 37223 | 2964 | 79704051 |
Viral load increased | 498.98 | 13.48 | 138 | 37235 | 2810 | 79704205 |
Renal tubular disorder | 461.70 | 13.48 | 156 | 37217 | 6330 | 79700685 |
Exposure during pregnancy | 447.40 | 13.48 | 374 | 36999 | 100758 | 79606257 |
Nephropathy toxic | 439.44 | 13.48 | 207 | 37166 | 20212 | 79686803 |
Fanconi syndrome | 416.55 | 13.48 | 119 | 37254 | 2737 | 79704278 |
Osteoporosis | 371.25 | 13.48 | 260 | 37113 | 53852 | 79653163 |
Genotype drug resistance test positive | 369.75 | 13.48 | 92 | 37281 | 1216 | 79705799 |
Stillbirth | 365.86 | 13.48 | 116 | 37257 | 3839 | 79703176 |
Hepatitis B | 333.32 | 13.48 | 131 | 37242 | 8201 | 79698814 |
Eyelid ptosis | 310.67 | 13.48 | 135 | 37238 | 10909 | 79696106 |
Maternal exposure during pregnancy | 301.31 | 13.48 | 345 | 37028 | 136193 | 79570822 |
Hypophosphataemia | 298.63 | 13.48 | 158 | 37215 | 19755 | 79687260 |
Abortion induced | 295.77 | 13.48 | 115 | 37258 | 6994 | 79700021 |
Progressive external ophthalmoplegia | 292.98 | 13.48 | 78 | 37295 | 1367 | 79705648 |
Hepatitis B reactivation | 265.47 | 13.48 | 102 | 37271 | 6006 | 79701009 |
Proteinuria | 262.93 | 13.48 | 173 | 37200 | 32329 | 79674686 |
Glycosuria | 260.97 | 13.48 | 78 | 37295 | 2110 | 79704905 |
CD4 lymphocytes decreased | 242.57 | 13.48 | 77 | 37296 | 2557 | 79704458 |
Renal tubular dysfunction | 236.51 | 13.48 | 58 | 37315 | 719 | 79706296 |
Hepatitis B DNA increased | 233.75 | 13.48 | 58 | 37315 | 757 | 79706258 |
Acquired gene mutation | 200.36 | 13.48 | 64 | 37309 | 2169 | 79704846 |
Blood creatinine increased | 197.30 | 13.48 | 299 | 37074 | 154758 | 79552257 |
Renal tubular acidosis | 192.27 | 13.48 | 70 | 37303 | 3544 | 79703471 |
Osteomalacia | 186.26 | 13.48 | 55 | 37318 | 1425 | 79705590 |
Diplopia | 171.48 | 13.48 | 135 | 37238 | 33331 | 79673684 |
Blood phosphorus decreased | 160.22 | 13.48 | 73 | 37300 | 6595 | 79700420 |
Jaundice | 156.69 | 13.48 | 157 | 37216 | 53192 | 79653823 |
Renal failure | 155.32 | 13.48 | 311 | 37062 | 200657 | 79506358 |
Pregnancy | 154.38 | 13.48 | 116 | 37257 | 26735 | 79680280 |
Caesarean section | 148.08 | 13.48 | 85 | 37288 | 12450 | 79694565 |
Foetal exposure during pregnancy | 144.21 | 13.48 | 65 | 37308 | 5725 | 79701290 |
Acute kidney injury | 143.01 | 13.48 | 550 | 36823 | 518854 | 79188161 |
Treatment noncompliance | 142.91 | 13.48 | 148 | 37225 | 52120 | 79654895 |
Osteonecrosis | 141.43 | 13.48 | 117 | 37256 | 30978 | 79676037 |
Alanine aminotransferase increased | 140.74 | 13.48 | 264 | 37109 | 162306 | 79544709 |
Renal tubular necrosis | 134.76 | 13.48 | 104 | 37269 | 24935 | 79682080 |
Aspartate aminotransferase increased | 132.47 | 13.48 | 235 | 37138 | 138406 | 79568609 |
Renal impairment | 122.83 | 13.48 | 245 | 37128 | 157538 | 79549477 |
Chronic kidney disease | 122.44 | 13.48 | 153 | 37220 | 66001 | 79641014 |
Hepatic failure | 120.44 | 13.48 | 146 | 37227 | 61066 | 79645949 |
Drug interaction | 117.71 | 13.48 | 444 | 36929 | 414739 | 79292276 |
CSF HIV escape syndrome | 116.33 | 13.48 | 28 | 37345 | 319 | 79706696 |
Renal colic | 114.99 | 13.48 | 45 | 37328 | 2782 | 79704233 |
Hepatic cytolysis | 106.79 | 13.48 | 94 | 37279 | 27057 | 79679958 |
HIV-associated neurocognitive disorder | 105.74 | 13.48 | 26 | 37347 | 326 | 79706689 |
Multiple-drug resistance | 104.76 | 13.48 | 60 | 37313 | 8748 | 79698267 |
Joint swelling | 102.10 | 13.48 | 9 | 37364 | 288637 | 79418378 |
Hypophosphataemic osteomalacia | 95.16 | 13.48 | 24 | 37349 | 336 | 79706679 |
Pain | 94.29 | 13.48 | 115 | 37258 | 703687 | 79003328 |
Arthrodesis | 93.29 | 13.48 | 37 | 37336 | 2370 | 79704645 |
Hepatocellular carcinoma | 92.95 | 13.48 | 56 | 37317 | 8965 | 79698050 |
Premature labour | 91.44 | 13.48 | 54 | 37319 | 8336 | 79698679 |
Live birth | 90.42 | 13.48 | 73 | 37300 | 18671 | 79688344 |
Lactic acidosis | 86.99 | 13.48 | 134 | 37239 | 70225 | 79636790 |
Hepatitis B DNA assay positive | 84.84 | 13.48 | 17 | 37356 | 74 | 79706941 |
Infusion related reaction | 84.71 | 13.48 | 6 | 37367 | 230231 | 79476784 |
Ultrasound antenatal screen | 83.92 | 13.48 | 25 | 37348 | 668 | 79706347 |
Premature delivery | 83.91 | 13.48 | 77 | 37296 | 23390 | 79683625 |
Nephrolithiasis | 82.65 | 13.48 | 113 | 37260 | 53178 | 79653837 |
Hepatic cirrhosis | 81.60 | 13.48 | 91 | 37282 | 34815 | 79672200 |
Hyperbilirubinaemia | 81.02 | 13.48 | 77 | 37296 | 24441 | 79682574 |
Peripheral swelling | 77.46 | 13.48 | 16 | 37357 | 269601 | 79437414 |
Blood bilirubin increased | 76.14 | 13.48 | 122 | 37251 | 66110 | 79640905 |
Nasopharyngitis | 75.17 | 13.48 | 14 | 37359 | 253867 | 79453148 |
Cushing's syndrome | 75.02 | 13.48 | 25 | 37348 | 970 | 79706045 |
Premature rupture of membranes | 74.64 | 13.48 | 37 | 37336 | 4032 | 79702983 |
Pneumonia | 73.43 | 13.48 | 123 | 37250 | 660123 | 79046892 |
Hydrops foetalis | 72.69 | 13.48 | 23 | 37350 | 755 | 79706260 |
Acute HIV infection | 70.62 | 13.48 | 14 | 37359 | 57 | 79706958 |
Rebound effect | 69.69 | 13.48 | 43 | 37330 | 7183 | 79699832 |
Psychiatric decompensation | 69.64 | 13.48 | 35 | 37338 | 3928 | 79703087 |
Dyspnoea | 69.28 | 13.48 | 191 | 37182 | 856834 | 78850181 |
Ophthalmoplegia | 67.19 | 13.48 | 31 | 37342 | 2881 | 79704134 |
Cleft lip and palate | 66.73 | 13.48 | 21 | 37352 | 677 | 79706338 |
Gene mutation | 66.40 | 13.48 | 30 | 37343 | 2656 | 79704359 |
Trisomy 18 | 65.28 | 13.48 | 20 | 37353 | 589 | 79706426 |
Portal hypertension | 65.27 | 13.48 | 41 | 37332 | 7067 | 79699948 |
Pulmonary tuberculosis | 63.90 | 13.48 | 42 | 37331 | 7823 | 79699192 |
Fall | 63.81 | 13.48 | 81 | 37292 | 487548 | 79219467 |
Hepatitis | 63.16 | 13.48 | 102 | 37271 | 55625 | 79651390 |
Lipoatrophy | 62.85 | 13.48 | 20 | 37353 | 669 | 79706346 |
Brain stem stroke | 62.01 | 13.48 | 20 | 37353 | 699 | 79706316 |
Blood creatine phosphokinase increased | 61.74 | 13.48 | 111 | 37262 | 65979 | 79641036 |
Depression suicidal | 59.03 | 13.48 | 31 | 37342 | 3811 | 79703204 |
Malaria | 58.92 | 13.48 | 17 | 37356 | 405 | 79706610 |
Completed suicide | 58.56 | 13.48 | 21 | 37352 | 245746 | 79461269 |
Tearfulness | 58.37 | 13.48 | 36 | 37337 | 6009 | 79701006 |
Synovitis | 58.23 | 13.48 | 3 | 37370 | 150731 | 79556284 |
Fatigue | 58.06 | 13.48 | 232 | 37141 | 929495 | 78777520 |
Haemolytic anaemia | 57.05 | 13.48 | 55 | 37318 | 17765 | 79689250 |
Placental disorder | 56.90 | 13.48 | 20 | 37353 | 913 | 79706102 |
Oligohydramnios | 56.65 | 13.48 | 29 | 37344 | 3383 | 79703632 |
Cytomegalovirus chorioretinitis | 56.35 | 13.48 | 34 | 37339 | 5456 | 79701559 |
Psychomotor skills impaired | 55.22 | 13.48 | 33 | 37340 | 5204 | 79701811 |
Mitochondrial cytopathy | 54.95 | 13.48 | 16 | 37357 | 394 | 79706621 |
Foetal death | 53.59 | 13.48 | 38 | 37335 | 8006 | 79699009 |
Placenta praevia | 53.09 | 13.48 | 18 | 37355 | 737 | 79706278 |
Hypotension | 52.69 | 13.48 | 78 | 37295 | 440239 | 79266776 |
Megakaryocytes increased | 52.62 | 13.48 | 12 | 37361 | 106 | 79706909 |
Sinusitis | 51.40 | 13.48 | 14 | 37359 | 195487 | 79511528 |
Immune reconstitution inflammatory syndrome associated tuberculosis | 51.29 | 13.48 | 18 | 37355 | 818 | 79706197 |
Musculoskeletal stiffness | 51.05 | 13.48 | 10 | 37363 | 174998 | 79532017 |
Blood pressure increased | 50.45 | 13.48 | 18 | 37355 | 211342 | 79495673 |
Acquired immunodeficiency syndrome | 50.24 | 13.48 | 14 | 37359 | 293 | 79706722 |
Glomerular filtration rate decreased | 49.34 | 13.48 | 57 | 37316 | 22645 | 79684370 |
Depressive symptom | 49.04 | 13.48 | 33 | 37340 | 6390 | 79700625 |
Constipation | 47.27 | 13.48 | 38 | 37335 | 283012 | 79424003 |
Placental insufficiency | 46.11 | 13.48 | 18 | 37355 | 1105 | 79705910 |
Blood alkaline phosphatase increased | 44.92 | 13.48 | 95 | 37278 | 63569 | 79643446 |
Hepatic encephalopathy | 44.86 | 13.48 | 56 | 37317 | 24110 | 79682905 |
Osteopenia | 44.85 | 13.48 | 49 | 37324 | 18315 | 79688700 |
Hepatic cancer | 44.52 | 13.48 | 38 | 37335 | 10491 | 79696524 |
Arthralgia | 44.20 | 13.48 | 130 | 37243 | 571673 | 79135342 |
Varices oesophageal | 43.88 | 13.48 | 30 | 37343 | 5961 | 79701054 |
Ocular icterus | 43.78 | 13.48 | 29 | 37344 | 5471 | 79701544 |
Osteoporotic fracture | 42.85 | 13.48 | 26 | 37347 | 4214 | 79702801 |
Oesophageal candidiasis | 42.56 | 13.48 | 35 | 37338 | 9183 | 79697832 |
Hepatic function abnormal | 42.51 | 13.48 | 101 | 37272 | 73006 | 79634009 |
Kaposi's sarcoma | 41.48 | 13.48 | 15 | 37358 | 744 | 79706271 |
Malignant neoplasm progression | 41.32 | 13.48 | 7 | 37366 | 135983 | 79571032 |
Contusion | 40.35 | 13.48 | 10 | 37363 | 148766 | 79558249 |
Swelling | 40.21 | 13.48 | 26 | 37347 | 216685 | 79490330 |
Nervous system disorder | 40.21 | 13.48 | 56 | 37317 | 26800 | 79680215 |
Blood lactic acid increased | 40.17 | 13.48 | 39 | 37334 | 12705 | 79694310 |
Wound | 40.04 | 13.48 | 4 | 37369 | 116175 | 79590840 |
Systemic lupus erythematosus | 39.67 | 13.48 | 5 | 37368 | 121144 | 79585871 |
Adrenal suppression | 39 | 13.48 | 17 | 37356 | 1382 | 79705633 |
Febrile neutropenia | 38.57 | 13.48 | 31 | 37342 | 230968 | 79476047 |
Wheezing | 37.75 | 13.48 | 5 | 37368 | 116659 | 79590356 |
Pericarditis | 37.51 | 13.48 | 3 | 37370 | 104233 | 79602782 |
Blood phosphorus abnormal | 37.28 | 13.48 | 11 | 37362 | 284 | 79706731 |
Injection site pain | 36.66 | 13.48 | 8 | 37365 | 129830 | 79577185 |
Hepatitis fulminant | 36.55 | 13.48 | 29 | 37344 | 7233 | 79699782 |
Product use issue | 36.51 | 13.48 | 27 | 37346 | 209795 | 79497220 |
Hepatic fibrosis | 36.48 | 13.48 | 29 | 37344 | 7251 | 79699764 |
Atrial fibrillation | 36.36 | 13.48 | 24 | 37349 | 197862 | 79509153 |
Oxygen saturation decreased | 36.33 | 13.48 | 8 | 37365 | 129039 | 79577976 |
Paranoia | 36.02 | 13.48 | 45 | 37328 | 19387 | 79687628 |
Cough | 35.66 | 13.48 | 74 | 37299 | 366715 | 79340300 |
Beta 2 microglobulin urine increased | 35.04 | 13.48 | 9 | 37364 | 136 | 79706879 |
COVID-19 | 35.02 | 13.48 | 15 | 37358 | 157659 | 79549356 |
Lymphadenopathy | 34.75 | 13.48 | 77 | 37296 | 53170 | 79653845 |
Hepatic steatosis | 34.75 | 13.48 | 63 | 37310 | 37675 | 79669340 |
Spina bifida | 34.68 | 13.48 | 9 | 37364 | 142 | 79706873 |
Polydipsia | 34.58 | 13.48 | 27 | 37346 | 6578 | 79700437 |
Abnormal dreams | 34.25 | 13.48 | 34 | 37339 | 11378 | 79695637 |
Stomatitis | 34.16 | 13.48 | 13 | 37360 | 146744 | 79560271 |
CSF virus identified | 34.14 | 13.48 | 7 | 37366 | 35 | 79706980 |
Retroviral rebound syndrome | 33.75 | 13.48 | 6 | 37367 | 11 | 79707004 |
Product dose omission issue | 33.50 | 13.48 | 40 | 37333 | 247497 | 79459518 |
Gamma-glutamyltransferase increased | 33.38 | 13.48 | 77 | 37296 | 54603 | 79652412 |
Anal cancer | 33.37 | 13.48 | 13 | 37360 | 794 | 79706221 |
Rash maculo-papular | 33.17 | 13.48 | 78 | 37295 | 56000 | 79651015 |
Hepatitis D | 33.01 | 13.48 | 8 | 37365 | 94 | 79706921 |
Transaminases increased | 32.84 | 13.48 | 74 | 37299 | 51669 | 79655346 |
Influenza | 32.74 | 13.48 | 10 | 37363 | 129596 | 79577419 |
Lower respiratory tract infection | 32.58 | 13.48 | 10 | 37363 | 129210 | 79577805 |
AIDS cholangiopathy | 32.49 | 13.48 | 6 | 37367 | 15 | 79707000 |
Toxicity to various agents | 32.42 | 13.48 | 96 | 37277 | 421444 | 79285571 |
Tubulointerstitial nephritis | 31.67 | 13.48 | 61 | 37312 | 38174 | 79668841 |
Pulmonary embolism | 31.29 | 13.48 | 21 | 37352 | 171633 | 79535382 |
Hepatitis C | 31.20 | 13.48 | 33 | 37340 | 11892 | 79695123 |
Hypertriglyceridaemia | 31.12 | 13.48 | 34 | 37339 | 12706 | 79694309 |
Psychotic disorder | 30.62 | 13.48 | 63 | 37310 | 41339 | 79665676 |
Cerebral toxoplasmosis | 30.55 | 13.48 | 17 | 37356 | 2345 | 79704670 |
Hepatorenal syndrome | 30.47 | 13.48 | 21 | 37352 | 4228 | 79702787 |
Blood creatine phosphokinase MB increased | 30.39 | 13.48 | 18 | 37355 | 2793 | 79704222 |
Malaise | 29.97 | 13.48 | 123 | 37250 | 489746 | 79217269 |
Bradycardia | 29.94 | 13.48 | 13 | 37360 | 135544 | 79571471 |
Polyuria | 29.82 | 13.48 | 36 | 37337 | 14978 | 79692037 |
Off label use | 29.78 | 13.48 | 277 | 37096 | 906938 | 78800077 |
Polyhydramnios | 29.66 | 13.48 | 15 | 37358 | 1705 | 79705310 |
Blood antidiuretic hormone increased | 29.56 | 13.48 | 7 | 37366 | 74 | 79706941 |
Progressive multifocal leukoencephalopathy | 29.42 | 13.48 | 42 | 37331 | 20558 | 79686457 |
Ultrasound antenatal screen abnormal | 28.90 | 13.48 | 7 | 37366 | 82 | 79706933 |
Blood bicarbonate decreased | 28.88 | 13.48 | 22 | 37351 | 5169 | 79701846 |
Asthma | 28.22 | 13.48 | 14 | 37359 | 135081 | 79571934 |
Arthropathy | 28.05 | 13.48 | 25 | 37348 | 177086 | 79529929 |
Hepatosplenomegaly | 27.92 | 13.48 | 23 | 37350 | 6046 | 79700969 |
Premature baby | 27.86 | 13.48 | 19 | 37354 | 3761 | 79703254 |
HIV associated nephropathy | 27.54 | 13.48 | 9 | 37364 | 328 | 79706687 |
Cholestasis | 27.12 | 13.48 | 69 | 37304 | 52040 | 79654975 |
Lymphoma | 27.02 | 13.48 | 37 | 37336 | 17423 | 79689592 |
Pre-eclampsia | 26.93 | 13.48 | 24 | 37349 | 7017 | 79699998 |
Disease progression | 26.90 | 13.48 | 28 | 37345 | 184334 | 79522681 |
Dialysis | 26.89 | 13.48 | 38 | 37335 | 18424 | 79688591 |
Dysphagia | 26.87 | 13.48 | 121 | 37252 | 122015 | 79585000 |
Syphilis | 26.77 | 13.48 | 10 | 37363 | 544 | 79706471 |
Stress | 26.77 | 13.48 | 3 | 37370 | 79609 | 79627406 |
Myalgia | 26.41 | 13.48 | 163 | 37210 | 185478 | 79521537 |
Drug reaction with eosinophilia and systemic symptoms | 26.39 | 13.48 | 78 | 37295 | 64166 | 79642849 |
Autoimmune hepatitis | 26.30 | 13.48 | 30 | 37343 | 11753 | 79695262 |
HIV test positive | 26.06 | 13.48 | 7 | 37366 | 127 | 79706888 |
Toxoplasmosis | 25.88 | 13.48 | 16 | 37357 | 2681 | 79704334 |
Melanoderma | 25.81 | 13.48 | 9 | 37364 | 401 | 79706614 |
Hepatotoxicity | 25.69 | 13.48 | 67 | 37306 | 51285 | 79655730 |
Metabolic acidosis | 25.57 | 13.48 | 91 | 37282 | 82438 | 79624577 |
Shoulder arthroplasty | 25.39 | 13.48 | 17 | 37356 | 3265 | 79703750 |
Pain in extremity | 25.23 | 13.48 | 87 | 37286 | 364451 | 79342564 |
Secondary syphilis | 25.04 | 13.48 | 6 | 37367 | 67 | 79706948 |
Viraemia | 24.97 | 13.48 | 16 | 37357 | 2853 | 79704162 |
Foetal cardiac disorder | 24.91 | 13.48 | 5 | 37368 | 22 | 79706993 |
Calculus urinary | 24.64 | 13.48 | 15 | 37358 | 2445 | 79704570 |
Blood HIV RNA | 24.55 | 13.48 | 5 | 37368 | 24 | 79706991 |
Viral load decreased | 24.55 | 13.48 | 5 | 37368 | 24 | 79706991 |
Rickets | 24.42 | 13.48 | 6 | 37367 | 75 | 79706940 |
Maternal drugs affecting foetus | 24.22 | 13.48 | 13 | 37360 | 1670 | 79705345 |
Drug-induced liver injury | 24.11 | 13.48 | 77 | 37296 | 66040 | 79640975 |
Anaphylactic reaction | 23.96 | 13.48 | 5 | 37368 | 83738 | 79623277 |
Cardiac failure congestive | 23.90 | 13.48 | 19 | 37354 | 142383 | 79564632 |
Arthritis | 23.85 | 13.48 | 12 | 37361 | 114868 | 79592147 |
Pathological fracture | 23.81 | 13.48 | 27 | 37346 | 10510 | 79696505 |
Nephropathy | 23.81 | 13.48 | 26 | 37347 | 9712 | 79697303 |
Pulmonary oedema | 23.79 | 13.48 | 6 | 37367 | 88248 | 79618767 |
Ectopic pregnancy | 23.79 | 13.48 | 13 | 37360 | 1730 | 79705285 |
Bronchitis | 23.78 | 13.48 | 16 | 37357 | 130628 | 79576387 |
Back pain | 23.56 | 13.48 | 69 | 37304 | 304111 | 79402904 |
Impaired healing | 23.55 | 13.48 | 6 | 37367 | 87649 | 79619366 |
Benign hydatidiform mole | 23.53 | 13.48 | 6 | 37367 | 88 | 79706927 |
Inappropriate schedule of product administration | 23.49 | 13.48 | 17 | 37356 | 133611 | 79573404 |
Hepatomegaly | 23.39 | 13.48 | 36 | 37337 | 18838 | 79688177 |
CSF test abnormal | 23.35 | 13.48 | 9 | 37364 | 534 | 79706481 |
Heart rate decreased | 22.78 | 13.48 | 3 | 37370 | 70313 | 79636702 |
Blister | 22.61 | 13.48 | 14 | 37359 | 119462 | 79587553 |
Acute hepatitis C | 22.47 | 13.48 | 7 | 37366 | 218 | 79706797 |
Urine calcium increased | 22.43 | 13.48 | 6 | 37367 | 107 | 79706908 |
Mycobacterium avium complex infection | 22.36 | 13.48 | 18 | 37355 | 4582 | 79702433 |
Pneumocystis jirovecii pneumonia | 22.33 | 13.48 | 48 | 37325 | 32460 | 79674555 |
Hyperphosphaturia | 22.33 | 13.48 | 6 | 37367 | 109 | 79706906 |
Type III hyperlipidaemia | 22.27 | 13.48 | 4 | 37369 | 8 | 79707007 |
Urinary tract infection | 22.19 | 13.48 | 61 | 37312 | 274451 | 79432564 |
Meningitis cryptococcal | 22.06 | 13.48 | 16 | 37357 | 3490 | 79703525 |
Discomfort | 22.05 | 13.48 | 16 | 37357 | 125601 | 79581414 |
Kidney fibrosis | 21.94 | 13.48 | 16 | 37357 | 3519 | 79703496 |
Antiviral drug level below therapeutic | 21.84 | 13.48 | 5 | 37368 | 45 | 79706970 |
Injection site erythema | 21.70 | 13.48 | 5 | 37368 | 78192 | 79628823 |
Dyslipidaemia | 21.66 | 13.48 | 27 | 37346 | 11606 | 79695409 |
Hypouricaemia | 21.62 | 13.48 | 8 | 37365 | 424 | 79706591 |
Cerebellar syndrome | 21.60 | 13.48 | 19 | 37354 | 5461 | 79701554 |
Dermatitis exfoliative | 21.56 | 13.48 | 26 | 37347 | 10803 | 79696212 |
Hepatitis A | 21.45 | 13.48 | 10 | 37363 | 951 | 79706064 |
Injury | 21.42 | 13.48 | 5 | 37368 | 77491 | 79629524 |
Blood pressure systolic increased | 21.36 | 13.48 | 3 | 37370 | 66983 | 79640032 |
Hyperlactacidaemia | 21.25 | 13.48 | 19 | 37354 | 5576 | 79701439 |
Chest discomfort | 21.24 | 13.48 | 20 | 37353 | 138024 | 79568991 |
Therapeutic product effect incomplete | 21.24 | 13.48 | 21 | 37352 | 141624 | 79565391 |
Feeling abnormal | 21.23 | 13.48 | 26 | 37347 | 159173 | 79547842 |
Eyelid oedema | 21.17 | 13.48 | 29 | 37344 | 13658 | 79693357 |
Cholestasis of pregnancy | 21.14 | 13.48 | 10 | 37363 | 983 | 79706032 |
Aplasia pure red cell | 21.12 | 13.48 | 22 | 37351 | 7788 | 79699227 |
Normal newborn | 21.09 | 13.48 | 21 | 37352 | 7051 | 79699964 |
Nasal congestion | 21.04 | 13.48 | 5 | 37368 | 76547 | 79630468 |
Hyperhidrosis | 21.00 | 13.48 | 24 | 37349 | 151468 | 79555547 |
Haemophilic arthropathy | 20.91 | 13.48 | 6 | 37367 | 140 | 79706875 |
Loss of personal independence in daily activities | 20.87 | 13.48 | 11 | 37362 | 102569 | 79604446 |
Liver function test abnormal | 20.76 | 13.48 | 72 | 37301 | 64403 | 79642612 |
Dizziness | 20.73 | 13.48 | 153 | 37220 | 526288 | 79180727 |
C-reactive protein increased | 20.68 | 13.48 | 18 | 37355 | 129009 | 79578006 |
Retinal toxicity | 20.59 | 13.48 | 11 | 37362 | 1400 | 79705615 |
Alopecia | 20.56 | 13.48 | 49 | 37324 | 231306 | 79475709 |
Oropharyngeal pain | 20.44 | 13.48 | 13 | 37360 | 109340 | 79597675 |
Red blood cell abnormality | 20.40 | 13.48 | 9 | 37364 | 753 | 79706262 |
Rhabdomyolysis | 20.35 | 13.48 | 99 | 37274 | 103032 | 79603983 |
Death | 20.29 | 13.48 | 169 | 37204 | 566345 | 79140670 |
Helicobacter infection | 20.28 | 13.48 | 4 | 37369 | 69700 | 79637315 |
Vitamin D deficiency | 20.22 | 13.48 | 29 | 37344 | 14250 | 79692765 |
Pancreatitis acute | 20.16 | 13.48 | 60 | 37313 | 49544 | 79657471 |
Limb operation | 20.13 | 13.48 | 15 | 37358 | 3411 | 79703604 |
Pancreatitis | 19.88 | 13.48 | 74 | 37299 | 68501 | 79638514 |
Lymphocytic infiltration | 19.60 | 13.48 | 11 | 37362 | 1542 | 79705473 |
White matter lesion | 19.41 | 13.48 | 12 | 37361 | 2010 | 79705005 |
Musculoskeletal pain | 19.36 | 13.48 | 12 | 37361 | 102342 | 79604673 |
Syncope | 19.34 | 13.48 | 34 | 37339 | 179415 | 79527600 |
Anaemia macrocytic | 19.30 | 13.48 | 18 | 37355 | 5579 | 79701436 |
Drug abuse | 19.24 | 13.48 | 29 | 37344 | 162662 | 79544353 |
Liver disorder | 19.23 | 13.48 | 76 | 37297 | 72341 | 79634674 |
Blood triglycerides increased | 19.21 | 13.48 | 35 | 37338 | 21005 | 79686010 |
Hyperphosphataemia | 19.14 | 13.48 | 19 | 37354 | 6357 | 79700658 |
Cellulitis | 19.00 | 13.48 | 14 | 37359 | 109046 | 79597969 |
Meningomyelocele | 18.89 | 13.48 | 4 | 37369 | 24 | 79706991 |
Urine phosphorus increased | 18.86 | 13.48 | 5 | 37368 | 86 | 79706929 |
Loss of consciousness | 18.85 | 13.48 | 31 | 37342 | 167912 | 79539103 |
Portal fibrosis | 18.80 | 13.48 | 8 | 37365 | 613 | 79706402 |
ACTH stimulation test abnormal | 18.75 | 13.48 | 4 | 37369 | 25 | 79706990 |
Anogenital warts | 18.65 | 13.48 | 9 | 37364 | 925 | 79706090 |
Weight increased | 18.64 | 13.48 | 67 | 37306 | 277319 | 79429696 |
Cortisol decreased | 18.63 | 13.48 | 12 | 37361 | 2160 | 79704855 |
Bone pain | 18.60 | 13.48 | 63 | 37310 | 55679 | 79651336 |
Neurosyphilis | 18.36 | 13.48 | 4 | 37369 | 28 | 79706987 |
Splenomegaly | 18.29 | 13.48 | 34 | 37339 | 20720 | 79686295 |
Acute respiratory failure | 18.22 | 13.48 | 3 | 37370 | 59538 | 79647477 |
Cardiac arrest | 18.19 | 13.48 | 33 | 37340 | 172063 | 79534952 |
Nodular regenerative hyperplasia | 18.16 | 13.48 | 10 | 37363 | 1351 | 79705664 |
Abortion infected | 18.12 | 13.48 | 4 | 37369 | 30 | 79706985 |
Cachexia | 17.93 | 13.48 | 24 | 37349 | 11059 | 79695956 |
Rash | 17.93 | 13.48 | 375 | 36998 | 577983 | 79129032 |
Gynaecomastia | 17.90 | 13.48 | 20 | 37353 | 7661 | 79699354 |
Abdominal pain upper | 17.89 | 13.48 | 50 | 37323 | 223769 | 79483246 |
Creatinine renal clearance decreased | 17.84 | 13.48 | 32 | 37341 | 18970 | 79688045 |
Blood bilirubin unconjugated increased | 17.76 | 13.48 | 9 | 37364 | 1028 | 79705987 |
Disseminated tuberculosis | 17.49 | 13.48 | 15 | 37358 | 4168 | 79702847 |
Ascites | 17.47 | 13.48 | 76 | 37297 | 75486 | 79631529 |
Oesophageal varices haemorrhage | 17.32 | 13.48 | 15 | 37358 | 4221 | 79702794 |
Mobility decreased | 17.32 | 13.48 | 19 | 37354 | 122156 | 79584859 |
Rhinorrhoea | 17.27 | 13.48 | 7 | 37366 | 76067 | 79630948 |
Nephrocalcinosis | 17.24 | 13.48 | 10 | 37363 | 1492 | 79705523 |
Burkitt's lymphoma | 17.14 | 13.48 | 5 | 37368 | 124 | 79706891 |
HIV infection | 17.05 | 13.48 | 9 | 37364 | 1118 | 79705897 |
Pancytopenia | 16.79 | 13.48 | 134 | 37239 | 165611 | 79541404 |
Ill-defined disorder | 16.78 | 13.48 | 5 | 37368 | 65870 | 79641145 |
Liver transplant | 16.76 | 13.48 | 15 | 37358 | 4408 | 79702607 |
Mitochondrial myopathy | 16.72 | 13.48 | 6 | 37367 | 291 | 79706724 |
Hyperbilirubinaemia neonatal | 16.71 | 13.48 | 3 | 37370 | 6 | 79707009 |
Hydromyelia | 16.71 | 13.48 | 3 | 37370 | 6 | 79707009 |
Carbon dioxide combining power abnormal | 16.71 | 13.48 | 3 | 37370 | 6 | 79707009 |
Glycocholic acid increased | 16.71 | 13.48 | 3 | 37370 | 6 | 79707009 |
Pneumonitis | 16.67 | 13.48 | 4 | 37369 | 60856 | 79646159 |
Chromaturia | 16.53 | 13.48 | 37 | 37336 | 25709 | 79681306 |
Meningitis tuberculous | 16.48 | 13.48 | 9 | 37364 | 1196 | 79705819 |
Pregnancy on oral contraceptive | 16.44 | 13.48 | 8 | 37365 | 837 | 79706178 |
Urine uric acid increased | 16.43 | 13.48 | 4 | 37369 | 48 | 79706967 |
Nephrogenic diabetes insipidus | 16.38 | 13.48 | 11 | 37362 | 2123 | 79704892 |
Hodgkin's disease | 16.31 | 13.48 | 8 | 37365 | 852 | 79706163 |
Psoriasis | 16.27 | 13.48 | 11 | 37362 | 89576 | 79617439 |
Amylase increased | 16.22 | 13.48 | 23 | 37350 | 11186 | 79695829 |
Blood corticotrophin decreased | 16.20 | 13.48 | 7 | 37366 | 557 | 79706458 |
Lipohypertrophy | 16.10 | 13.48 | 8 | 37365 | 876 | 79706139 |
CD4 lymphocytes abnormal | 15.99 | 13.48 | 4 | 37369 | 54 | 79706961 |
Psychomotor retardation | 15.98 | 13.48 | 17 | 37356 | 6167 | 79700848 |
Vth nerve injury | 15.84 | 13.48 | 3 | 37370 | 9 | 79707006 |
Necrotising enterocolitis neonatal | 15.84 | 13.48 | 3 | 37370 | 9 | 79707006 |
Glucose urine present | 15.80 | 13.48 | 10 | 37363 | 1746 | 79705269 |
AIDS related complication | 15.73 | 13.48 | 4 | 37369 | 58 | 79706957 |
Pharyngeal cancer | 15.73 | 13.48 | 4 | 37369 | 58 | 79706957 |
Dry mouth | 15.72 | 13.48 | 11 | 37362 | 88008 | 79619007 |
Optic nerve cupping | 15.67 | 13.48 | 4 | 37369 | 59 | 79706956 |
Haematochezia | 15.60 | 13.48 | 11 | 37362 | 87634 | 79619381 |
Muscle spasms | 15.52 | 13.48 | 37 | 37336 | 174693 | 79532322 |
Upper respiratory tract infection | 15.50 | 13.48 | 12 | 37361 | 91156 | 79615859 |
Erectile dysfunction | 15.47 | 13.48 | 26 | 37347 | 14638 | 79692377 |
Pneumonia aspiration | 15.47 | 13.48 | 6 | 37367 | 66961 | 79640054 |
Hyperproteinaemia | 15.44 | 13.48 | 5 | 37368 | 177 | 79706838 |
Cystitis | 15.39 | 13.48 | 3 | 37370 | 52729 | 79654286 |
Hypersensitivity | 15.30 | 13.48 | 67 | 37306 | 262172 | 79444843 |
Anaemia | 15.26 | 13.48 | 293 | 37080 | 444722 | 79262293 |
Prognathism | 15.18 | 13.48 | 3 | 37370 | 12 | 79707003 |
Antiviral drug level above therapeutic | 15.08 | 13.48 | 4 | 37369 | 69 | 79706946 |
Haemodialysis | 15.06 | 13.48 | 29 | 37344 | 18139 | 79688876 |
HIV wasting syndrome | 14.92 | 13.48 | 4 | 37369 | 72 | 79706943 |
Chronic obstructive pulmonary disease | 14.83 | 13.48 | 11 | 37362 | 85408 | 79621607 |
Tuberculosis | 14.79 | 13.48 | 26 | 37347 | 15172 | 79691843 |
Anembryonic gestation | 14.76 | 13.48 | 6 | 37367 | 410 | 79706605 |
Congenital diaphragmatic hernia | 14.63 | 13.48 | 3 | 37370 | 15 | 79707000 |
Blood pressure decreased | 14.62 | 13.48 | 15 | 37358 | 99451 | 79607564 |
Disseminated mycobacterium avium complex infection | 14.58 | 13.48 | 5 | 37368 | 212 | 79706803 |
Lipase increased | 14.54 | 13.48 | 27 | 37346 | 16439 | 79690576 |
Bone density decreased | 14.53 | 13.48 | 24 | 37349 | 13323 | 79693692 |
Unmasking of previously unidentified disease | 14.36 | 13.48 | 10 | 37363 | 2047 | 79704968 |
Albuminuria | 14.30 | 13.48 | 7 | 37366 | 742 | 79706273 |
Chronic hepatitis B | 14.29 | 13.48 | 6 | 37367 | 445 | 79706570 |
Hemiparaesthesia | 14.09 | 13.48 | 5 | 37368 | 235 | 79706780 |
Gestational diabetes | 14.01 | 13.48 | 16 | 37357 | 6277 | 79700738 |
Bone marrow disorder | 14.00 | 13.48 | 12 | 37361 | 3331 | 79703684 |
Total bile acids increased | 13.96 | 13.48 | 4 | 37369 | 93 | 79706922 |
Hepatitis cholestatic | 13.88 | 13.48 | 24 | 37349 | 13828 | 79693187 |
Haemorrhoids thrombosed | 13.83 | 13.48 | 5 | 37368 | 248 | 79706767 |
Generalised anxiety disorder | 13.76 | 13.48 | 10 | 37363 | 2187 | 79704828 |
Skin lesion | 13.70 | 13.48 | 47 | 37326 | 41797 | 79665218 |
Muscle injury | 13.69 | 13.48 | 3 | 37370 | 48558 | 79658457 |
Plasma cell myeloma | 13.64 | 13.48 | 4 | 37369 | 53255 | 79653760 |
Cervix haemorrhage uterine | 13.53 | 13.48 | 3 | 37370 | 23 | 79706992 |
Bone metabolism disorder | 13.49 | 13.48 | 6 | 37367 | 512 | 79706503 |
None
Source | Code | Description |
---|---|---|
ATC | J05AF07 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIVIRALS FOR SYSTEMIC USE DIRECT ACTING ANTIVIRALS Nucleoside and nucleotide reverse transcriptase inhibitors |
ATC | J05AR03 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIVIRALS FOR SYSTEMIC USE DIRECT ACTING ANTIVIRALS Antivirals for treatment of HIV infections, combinations |
ATC | J05AR06 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIVIRALS FOR SYSTEMIC USE DIRECT ACTING ANTIVIRALS Antivirals for treatment of HIV infections, combinations |
ATC | J05AR08 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIVIRALS FOR SYSTEMIC USE DIRECT ACTING ANTIVIRALS Antivirals for treatment of HIV infections, combinations |
ATC | J05AR09 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIVIRALS FOR SYSTEMIC USE DIRECT ACTING ANTIVIRALS Antivirals for treatment of HIV infections, combinations |
ATC | J05AR11 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIVIRALS FOR SYSTEMIC USE DIRECT ACTING ANTIVIRALS Antivirals for treatment of HIV infections, combinations |
ATC | J05AR12 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIVIRALS FOR SYSTEMIC USE DIRECT ACTING ANTIVIRALS Antivirals for treatment of HIV infections, combinations |
ATC | J05AR24 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIVIRALS FOR SYSTEMIC USE DIRECT ACTING ANTIVIRALS Antivirals for treatment of HIV infections, combinations |
ATC | J05AR27 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIVIRALS FOR SYSTEMIC USE DIRECT ACTING ANTIVIRALS Antivirals for treatment of HIV infections, combinations |
MeSH PA | D019380 | Anti-HIV Agents |
MeSH PA | D000890 | Anti-Infective Agents |
MeSH PA | D044966 | Anti-Retroviral Agents |
MeSH PA | D000998 | Antiviral Agents |
MeSH PA | D004791 | Enzyme Inhibitors |
MeSH PA | D019384 | Nucleic Acid Synthesis Inhibitors |
MeSH PA | D018894 | Reverse Transcriptase Inhibitors |
CHEBI has role | CHEBI:36044 | antiviral drugs |
CHEBI has role | CHEBI:53756 | reverse transcriptase inhibitors |
CHEBI has role | CHEBI:50266 | Prodrugs |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Chronic type B viral hepatitis | indication | 61977001 | |
Human immunodeficiency virus infection | indication | 86406008 | DOID:526 |
Prevention of HIV Infection after Exposure | off-label use | ||
Osteomalacia | contraindication | 4598005 | DOID:10573 |
Hypophosphatemia | contraindication | 4996001 | |
Suicidal thoughts | contraindication | 6471006 | |
Hypercholesterolemia | contraindication | 13644009 | |
Torsades de pointes | contraindication | 31722008 | |
Depressive disorder | contraindication | 35489007 | |
Fanconi syndrome | contraindication | 40488004 | DOID:1062 |
Acute nephropathy | contraindication | 58574008 | |
Hepatic failure | contraindication | 59927004 | |
Aggressive behavior | contraindication | 61372001 | |
Kidney disease | contraindication | 90708001 | DOID:557 |
Lactic acidosis | contraindication | 91273001 | DOID:3650 |
Prolonged QT interval | contraindication | 111975006 | |
Chronic hepatitis C | contraindication | 128302006 | |
Seizure disorder | contraindication | 128613002 | |
Liver function tests abnormal | contraindication | 166603001 | |
Paranoid disorder | contraindication | 191667009 | |
Steatosis of liver | contraindication | 197321007 | |
Mania | contraindication | 231494001 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Pathological fracture | contraindication | 268029009 | |
Pregnancy, function | contraindication | 289908002 | |
Hypertriglyceridemia | contraindication | 302870006 | |
Severe depression | contraindication | 310497006 | |
Osteopenia | contraindication | 312894000 | |
Breastfeeding (mother) | contraindication | 413712001 | |
Obesity | contraindication | 414916001 | DOID:9970 |
Congenital long QT syndrome | contraindication | 442917000 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 4.86 | Basic |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
---|---|---|---|---|---|---|---|---|---|---|
200MG;300MG | TRUVADA | GILEAD | N021752 | Aug. 2, 2004 | RX | TABLET | ORAL | 8592397 | Jan. 13, 2024 | METHOD OF TREATMENT OF ADULTS INFECTED WITH HIV-1 |
200MG;300MG | TRUVADA | GILEAD | N021752 | Aug. 2, 2004 | RX | TABLET | ORAL | 8592397 | Jan. 13, 2024 | TREATMENT OF HIV |
200MG;300MG | TRUVADA | GILEAD | N021752 | Aug. 2, 2004 | RX | TABLET | ORAL | 8592397 | Jan. 13, 2024 | TREATMENT OF HIV-1 INFECTION IN PEDIATRIC PATIENTS 12 YEARS OF AGE AND OLDER |
200MG;300MG | TRUVADA | GILEAD | N021752 | Aug. 2, 2004 | RX | TABLET | ORAL | 8716264 | Jan. 13, 2024 | TREATMENT OF HIV INFECTION |
200MG;300MG | TRUVADA | GILEAD | N021752 | Aug. 2, 2004 | RX | TABLET | ORAL | 9457036 | Jan. 13, 2024 | TREATMENT OF HIV INFECTION |
200MG;300MG | TRUVADA | GILEAD | N021752 | Aug. 2, 2004 | RX | TABLET | ORAL | 9744181 | Jan. 13, 2024 | TREATMENT OF HIV INFECTION |
600MG;200MG;300MG | ATRIPLA | GILEAD SCIENCES | N021937 | July 12, 2006 | RX | TABLET | ORAL | 8592397 | Jan. 13, 2024 | TREATMENT OF HIV-1 INFECTION IN ADULTS |
600MG;200MG;300MG | ATRIPLA | GILEAD SCIENCES | N021937 | July 12, 2006 | RX | TABLET | ORAL | 8592397 | Jan. 13, 2024 | TREATMENT OF HIV-1 INFECTION IN PEDIATRIC PATIENTS 12 YEARS OF AGE AND OLDER |
600MG;200MG;300MG | ATRIPLA | GILEAD SCIENCES | N021937 | July 12, 2006 | RX | TABLET | ORAL | 8716264 | Jan. 13, 2024 | TREATMENT OF HIV INFECTION |
600MG;200MG;300MG | ATRIPLA | GILEAD SCIENCES | N021937 | July 12, 2006 | RX | TABLET | ORAL | 9457036 | Jan. 13, 2024 | TREATMENT OF HIV INFECTION |
600MG;200MG;300MG | ATRIPLA | GILEAD SCIENCES | N021937 | July 12, 2006 | RX | TABLET | ORAL | 9744181 | Jan. 13, 2024 | TREATMENT OF HIV INFECTION |
200MG;EQ 25MG BASE;300MG | COMPLERA | GILEAD SCIENCES INC | N202123 | Aug. 10, 2011 | RX | TABLET | ORAL | 8592397 | Jan. 13, 2024 | TREATMENT OF HIV INFECTION |
200MG;EQ 25MG BASE;300MG | COMPLERA | GILEAD SCIENCES INC | N202123 | Aug. 10, 2011 | RX | TABLET | ORAL | 8716264 | Jan. 13, 2024 | TREATMENT OF HIV INFECTION |
200MG;EQ 25MG BASE;300MG | COMPLERA | GILEAD SCIENCES INC | N202123 | Aug. 10, 2011 | RX | TABLET | ORAL | 9457036 | Jan. 13, 2024 | TREATMENT OF HIV INFECTION |
200MG;EQ 25MG BASE;300MG | COMPLERA | GILEAD SCIENCES INC | N202123 | Aug. 10, 2011 | RX | TABLET | ORAL | 9744181 | Jan. 13, 2024 | TREATMENT OF HIV INFECTION |
150MG;150MG;200MG;300MG | STRIBILD | GILEAD SCIENCES INC | N203100 | Aug. 27, 2012 | RX | TABLET | ORAL | 8592397 | Jan. 13, 2024 | TREATMENT OF HIV INFECTION |
150MG;150MG;200MG;300MG | STRIBILD | GILEAD SCIENCES INC | N203100 | Aug. 27, 2012 | RX | TABLET | ORAL | 8716264 | Jan. 13, 2024 | TREATMENT OF HIV INFECTION |
150MG;150MG;200MG;300MG | STRIBILD | GILEAD SCIENCES INC | N203100 | Aug. 27, 2012 | RX | TABLET | ORAL | 9457036 | Jan. 13, 2024 | TREATMENT OF HIV INFECTION |
150MG;150MG;200MG;300MG | STRIBILD | GILEAD SCIENCES INC | N203100 | Aug. 27, 2012 | RX | TABLET | ORAL | 9744181 | Jan. 13, 2024 | TREATMENT OF HIV INFECTION |
200MG;EQ 25MG BASE;300MG | COMPLERA | GILEAD SCIENCES INC | N202123 | Aug. 10, 2011 | RX | TABLET | ORAL | 7125879 | April 21, 2025 | TREATMENT OF HIV INFECTION |
200MG;EQ 25MG BASE;300MG | COMPLERA | GILEAD SCIENCES INC | N202123 | Aug. 10, 2011 | RX | TABLET | ORAL | 8841310 | Dec. 9, 2025 | TREATMENT OF HIV INFECTION |
600MG;200MG;300MG | ATRIPLA | GILEAD SCIENCES | N021937 | July 12, 2006 | RX | TABLET | ORAL | 9018192 | June 13, 2026 | TREATMENT OF HIV-1 INFECTION IN ADULTS |
600MG;200MG;300MG | ATRIPLA | GILEAD SCIENCES | N021937 | July 12, 2006 | RX | TABLET | ORAL | 9018192 | June 13, 2026 | TREATMENT OF HIV-1 INFECTION IN PEDIATRIC PATIENTS 12 YEARS OF AGE AND OLDER |
600MG;200MG;300MG | ATRIPLA | GILEAD SCIENCES | N021937 | July 12, 2006 | RX | TABLET | ORAL | 9545414 | June 13, 2026 | TREATMENT OF HIV-1 INFECTION IN ADULTS |
600MG;200MG;300MG | ATRIPLA | GILEAD SCIENCES | N021937 | July 12, 2006 | RX | TABLET | ORAL | 9545414 | June 13, 2026 | TREATMENT OF HIV-1 INFECTION IN PEDIATRIC PATIENTS 12 YEARS OF AGE AND OLDER |
150MG;150MG;200MG;300MG | STRIBILD | GILEAD SCIENCES INC | N203100 | Aug. 27, 2012 | RX | TABLET | ORAL | 7176220 | Aug. 27, 2026 | TREATMENT OF HIV INFECTION |
150MG;150MG;200MG;300MG | STRIBILD | GILEAD SCIENCES INC | N203100 | Aug. 27, 2012 | RX | TABLET | ORAL | 7635704 | Oct. 26, 2026 | TREATMENT OF HIV INFECTION |
150MG;150MG;200MG;300MG | STRIBILD | GILEAD SCIENCES INC | N203100 | Aug. 27, 2012 | RX | TABLET | ORAL | 8148374 | Sept. 3, 2029 | TREATMENT OF HIV INFECTION USING A COMPOSITION CONTAINING A PHARMACOKINETIC ENHANCER THAT INHIBITS CYTOCHROME P450 MONOOXYGENASE |
150MG;150MG;200MG;300MG | STRIBILD | GILEAD SCIENCES INC | N203100 | Aug. 27, 2012 | RX | TABLET | ORAL | 9891239 | Sept. 3, 2029 | TREATMENT OF HIV INFECTION |
150MG;150MG;200MG;300MG | STRIBILD | GILEAD SCIENCES INC | N203100 | Aug. 27, 2012 | RX | TABLET | ORAL | 8633219 | April 30, 2030 | TREATMENT OF HIV INFECTION |
100MG;300MG;300MG | DELSTRIGO | MSD MERCK CO | N210807 | Aug. 30, 2018 | RX | TABLET | ORAL | 8486975 | Oct. 7, 2031 | FOR THE TREATMENT OF HIV-1 INFECTION IN ADULT PATIENTS WITH NO PRIOR ANTIRETROVIRAL TREATMENT HISTORY |
100MG;300MG;300MG | DELSTRIGO | MSD MERCK CO | N210807 | Aug. 30, 2018 | RX | TABLET | ORAL | 8486975 | Oct. 7, 2031 | TREATMENT OF HIV-1 INFECTION IN ADULT PATIENTS AS A REPLACEMENT THERAPY IN VIROLOGICALLY SUPPRESSED ADULTS WITH NO HISTORY OF TREATMENT FAILURE AND NO KNOWN SUBSTITUTIONS ASSOCIATED WITH RESISTANCE TO THE INDIVIDUAL COMPONENTS OF DELSTRIGO |
100MG;300MG;300MG | DELSTRIGO | MSD MERCK CO | N210807 | Aug. 30, 2018 | RX | TABLET | ORAL | 8486975 | Oct. 7, 2031 | TREATMENT OF HIV-1 INFECTION IN PEDIATRIC PATIENTS WEIGHING AT LEAST 35KG WITH NO PRIOR ANTIRETROVIRAL TREATMENT HISTORY OR TO REPLACE THE CURRENT ANTIRETROVIRAL REGIMEN IN THOSE WHO ARE VIROLOGICALLY SUPPRESSED |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Exclusivity date | Description |
---|---|---|---|---|---|---|---|---|---|
100MG;300MG;300MG | DELSTRIGO | MSD MERCK CO | N210807 | Aug. 30, 2018 | RX | TABLET | ORAL | Aug. 30, 2023 | NEW CHEMICAL ENTITY |
100MG;300MG;300MG | DELSTRIGO | MSD MERCK CO | N210807 | Aug. 30, 2018 | RX | TABLET | ORAL | Jan. 27, 2025 | NEW PATIENT POPULATION |
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Reverse transcriptase/RNaseH | Enzyme | INHIBITOR | CHEMBL | CHEMBL | |||||
Gag-Pol polyprotein | Polyprotein | WOMBAT-PK |
ID | Source |
---|---|
D01982 | KEGG_DRUG |
202138-50-9 | SECONDARY_CAS_RN |
4021279 | VANDF |
4021280 | VANDF |
C0384228 | UMLSCUI |
CHEBI:63718 | CHEBI |
CHEBI:63625 | CHEBI |
TFO | PDB_CHEM_ID |
CHEMBL1538 | ChEMBL_ID |
CHEMBL1486 | ChEMBL_ID |
D000068698 | MESH_DESCRIPTOR_UI |
DB00300 | DRUGBANK_ID |
F4YU4LON7I | UNII |
5481350 | PUBCHEM_CID |
DB14126 | DRUGBANK_ID |
117466 | RXNORM |
16193 | MMSL |
267164 | MMSL |
29323 | MMSL |
42402 | MMSL |
d04774 | MMSL |
009357 | NDDF |
009358 | NDDF |
017389 | NDDF |
385556006 | SNOMEDCT_US |
395264002 | SNOMEDCT_US |
421203005 | SNOMEDCT_US |
422091007 | SNOMEDCT_US |
206184-49-8 | SECONDARY_CAS_RN |
464205 | PUBCHEM_CID |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
DELSTRIGO | HUMAN PRESCRIPTION DRUG LABEL | 3 | 0006-5007 | TABLET, FILM COATED | 300 mg | ORAL | NDA | 32 sections |
DELSTRIGO | HUMAN PRESCRIPTION DRUG LABEL | 3 | 0006-5007 | TABLET, FILM COATED | 300 mg | ORAL | NDA | 32 sections |
Efavirenz, Emtricitabine and Tenofovir Disoproxil Fumarate | HUMAN PRESCRIPTION DRUG LABEL | 3 | 0093-5234 | TABLET, FILM COATED | 300 mg | ORAL | ANDA | 30 sections |
Efavirenz, Emtricitabine and Tenofovir Disoproxil Fumarate | HUMAN PRESCRIPTION DRUG LABEL | 3 | 0093-5234 | TABLET, FILM COATED | 300 mg | ORAL | ANDA | 30 sections |
Emtricitabine and Tenofovir Disoproxil Fumarate | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0093-7607 | TABLET, FILM COATED | 300 mg | ORAL | ANDA | 29 sections |
Emtricitabine and Tenofovir Disoproxil Fumarate | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0093-7704 | TABLET, FILM COATED | 300 mg | ORAL | ANDA | 29 sections |
Emtricitabine and Tenofovir Disoproxil Fumarate | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0093-7704 | TABLET, FILM COATED | 300 mg | ORAL | ANDA | 29 sections |
Emtricitabine and Tenofovir Disoproxil Fumarate | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0378-1930 | TABLET, FILM COATED | 300 mg | ORAL | ANDA | 30 sections |
tenofovir disproxil fumarate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6821 | TABLET | 300 mg | ORAL | ANDA | 27 sections |
Emtricitabine and Tenofovir Disoproxil Fumarate | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0904-7172 | TABLET, FILM COATED | 300 mg | ORAL | ANDA | 28 sections |
Emtricitabine and Tenofovir Disoproxil Fumarate | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0904-7172 | TABLET, FILM COATED | 300 mg | ORAL | ANDA | 28 sections |
Atripla | HUMAN PRESCRIPTION DRUG LABEL | 3 | 15584-0101 | TABLET, FILM COATED | 300 mg | ORAL | NDA | 34 sections |
Emtricitabine and tenofovir disoproxil fumarate | Human Prescription Drug Label | 2 | 16714-534 | TABLET, FILM COATED | 300 mg | ORAL | ANDA | 28 sections |
Emtricitabine and tenofovir disoproxil fumarate | Human Prescription Drug Label | 2 | 16714-534 | TABLET, FILM COATED | 300 mg | ORAL | ANDA | 28 sections |
Tenofovir Disoproxil Fumarate | Human Prescription Drug Label | 1 | 16714-820 | TABLET, FILM COATED | 300 mg | ORAL | ANDA | 27 sections |
Tenofovir Disoproxil Fumarate | Human Prescription Drug Label | 1 | 31722-535 | TABLET, FILM COATED | 300 mg | ORAL | ANDA | 30 sections |
Tenofovir Disoproxil Fumarate | Human Prescription Drug Label | 1 | 31722-535 | TABLET, FILM COATED | 300 mg | ORAL | ANDA | 30 sections |
Emtricitabine and tenofovir disoproxil fumarate | HUMAN PRESCRIPTION DRUG LABEL | 2 | 31722-560 | TABLET, FILM COATED | 300 mg | ORAL | ANDA | 27 sections |
Efavirenz, Emtricitabine and Tenofovir Disoproxil Fumarate | HUMAN PRESCRIPTION DRUG LABEL | 3 | 31722-736 | TABLET, FILM COATED | 300 mg | ORAL | ANDA | 28 sections |
tenofovir disproxil fumarate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 33342-096 | TABLET | 300 mg | ORAL | ANDA | 28 sections |
tenofovir disproxil fumarate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 33342-096 | TABLET | 300 mg | ORAL | ANDA | 28 sections |
tenofovir disproxil fumarate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 33342-096 | TABLET | 300 mg | ORAL | ANDA | 28 sections |
Emtricitabine and tenofovir disoproxil fumarate | Human Prescription Drug Label | 2 | 33342-106 | TABLET, FILM COATED | 300 mg | ORAL | ANDA | 28 sections |
Emtricitabine and tenofovir disoproxil fumarate | Human Prescription Drug Label | 2 | 33342-106 | TABLET, FILM COATED | 300 mg | ORAL | ANDA | 28 sections |
Efavirenz, Emtricitabine and Tenofovir Disoproxil Fumarate | Human Prescription Drug Label | 3 | 33342-138 | TABLET, FILM COATED | 300 mg | ORAL | ANDA | 30 sections |
Emtricitabine and Tenofovir Disoproxil Fumarate | HUMAN PRESCRIPTION DRUG LABEL | 2 | 42291-439 | TABLET, FILM COATED | 300 mg | ORAL | ANDA | 26 sections |
Emtricitabine and Tenofovir Disoproxil Fumarate | HUMAN PRESCRIPTION DRUG LABEL | 2 | 42291-439 | TABLET, FILM COATED | 300 mg | ORAL | ANDA | 26 sections |
Tenofovir Disoproxil Fumarate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42291-800 | TABLET, FILM COATED | 300 mg | ORAL | ANDA | 27 sections |
Tenofovir Disoproxil Fumarate | Human Prescription Drug Label | 1 | 42385-901 | TABLET, FILM COATED | 300 mg | ORAL | ANDA | 28 sections |
Efavirenz, emtricitabine and tenofovir disoproxil fumarate | Human Prescription Drug Label | 3 | 42385-915 | TABLET, FILM COATED | 300 mg | ORAL | ANDA | 30 sections |