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idebenone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 1416 | 58186-27-9 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 0.90 | g | O |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Benet LZ, Broccatelli F, Oprea TI |
| EoM (Fraction excreted unchanged in urine) | 0.50 % | Benet LZ, Broccatelli F, Oprea TI |
| S (Water solubility) | 0.01 mg/mL | Bocci G, Oprea TI, Benet LZ |
| BA (Bioavailability) | 1 % |
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2A,ACVR2B,ACVRL1,AKT2,AKT3,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK2,CDK4,CDK5,CDK9,CHEK1,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GRK3,GSK3B,IGF1R,IKBKB,ITK,JAK1,JAK2,JAK3,KDR,KIT,MAP2K6,MAP3K14,MAP3K21,MAP3K7,MAP4K1,MAPK10,MAPK12,MAPK7,MAPK9,MAPKAPK2,MARK4,MET,MTOR,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CA,PIK3CB,PIK3CD,PIK3CG,PIM1,PIM2,PLK1,PLK2,PLK3,PLK4,PRKCD,PRKDC,PTK2,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ULK1,ULK2,ZAP70 | 76 | |||
| kinase-selectivity-class | ACVR2B,AXL,BRAF,CAMK2A,CAMK2D,CDK16,CDK4,CDK9,DDR1,EIF2AK3,EPHB4,ERBB2,FLT4,GRK2,IRAK1,IRAK3,JAK2,MAP2K6,MAP3K14,MAP3K7,MAPK12,MAPK7,MAPK8,MARK4,MTOR,PLK1,PLK2,PLK3,PLK4,PRKDC,PTK2,SIK2,STK33,SYK,TEK,TTK,TYRO3,ULK1,ZAP70 | 39 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Sept. 8, 2015 | EMA |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | N06BX13 | NERVOUS SYSTEM PSYCHOANALEPTICS PSYCHOSTIMULANTS, AGENTS USED FOR ADHD AND NOOTROPICS Other psychostimulants and nootropics |
| MeSH PA | D000975 | Antioxidants |
| MeSH PA | D020011 | Protective Agents |
| CHEBI has role | CHEBI:22586 | antioxidant |
| CHEBI has role | CHEBI:35705 | immunosuppressive agent |
| CHEBI has role | CHEBI:173084 | ferroptosis inhibitor |
Related Drugs by ATC class:
N06BX Other psychostimulants and nootropics 19 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Leber's optic atrophy | indication | 58610003 | DOID:705 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Cytochrome P450 3A4 | Enzyme | IC50 | 5.16 | DRUG MATRIX | |||||
| Cytochrome P450 2D6 | Enzyme | IC50 | 5.52 | DRUG MATRIX | |||||
| Cytochrome P450 2C9 | Enzyme | IC50 | 5.30 | DRUG MATRIX | |||||
| Cytochrome P450 2C19 | Enzyme | IC50 | 6.10 | DRUG MATRIX | |||||
| NAD-dependent protein deacetylase | Enzyme | IC50 | 5.72 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D01750 | KEGG_DRUG |
| C0123163 | UMLSCUI |
| CHEBI:31687 | CHEBI |
| CHEMBL252556 | ChEMBL_ID |
| DB09081 | DRUGBANK_ID |
| C036619 | MESH_SUPPLEMENTAL_RECORD_UI |
| 3686 | PUBCHEM_CID |
| 5465 | INN_ID |
| HB6PN45W4J | UNII |
| 51296 | RXNORM |
| 006795 | NDDF |
| 428158006 | SNOMEDCT_US |
| 429666007 | SNOMEDCT_US |
Pharmaceutical products:
None