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halazepam 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| diazepam derivatives | 1348 | 23092-17-3 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 0.10 | g | O |
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2B,EIF2AK3,GRK2,MAPK7,PDK1,PDK2,PDK4 | 7 | |||
| mdck-mdr1-bcrp-efflux | MDCK-MDR1-BCRP efflux ratio | 0.531 | Moderate | 0.65 | |
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 1 | |||
| rat-kpuu-brain | Rat brain Kpuu | 1.012 | % | Moderate | 0.65 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Sept. 24, 1981 | FDA | SCHERING |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | N05BA13 | NERVOUS SYSTEM PSYCHOLEPTICS ANXIOLYTICS Benzodiazepine derivatives |
| MeSH PA | D002491 | Central Nervous System Agents |
| MeSH PA | D002492 | Central Nervous System Depressants |
| MeSH PA | D011619 | Psychotropic Drugs |
| MeSH PA | D014149 | Tranquilizing Agents |
| MeSH PA | D014151 | Anti-Anxiety Agents |
| CHEBI has role | CHEBI:35474 | anxiolytic drug |
Related Drugs by ATC class:
N05BA Benzodiazepine derivatives 23 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Anxiety | indication | 48694002 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 1.94 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| GABA-A receptor; anion channel | Ion channel | POSITIVE ALLOSTERIC MODULATOR | CHEMBL | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4018800 | VUID |
| N0000147103 | NUI |
| D00338 | KEGG_DRUG |
| 4018800 | VANDF |
| C0062092 | UMLSCUI |
| CHEBI:5603 | CHEBI |
| CHEMBL970 | ChEMBL_ID |
| DB00801 | DRUGBANK_ID |
| C010175 | MESH_SUPPLEMENTAL_RECORD_UI |
| 31640 | PUBCHEM_CID |
| 7195 | IUPHAR_LIGAND_ID |
| 3339 | INN_ID |
| 320YC168LF | UNII |
| 219119 | RXNORM |
| 3572 | MMSL |
| 4813 | MMSL |
| d00904 | MMSL |
| 001465 | NDDF |
| 371367008 | SNOMEDCT_US |
| 63545000 | SNOMEDCT_US |
Pharmaceutical products:
None