AI ASSISTANT
Ask DrugCentral
Explore drug information in your own words.
Type a question in the search bar above to get started. Each question is answered independently.
Try a sample question
Select a question to fill the search bar, then submit it or edit it first.
AI can make mistakes. Verify answers against the original sources before relying on them.
cloxazolam 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| diazepam derivatives | 721 | 24166-13-0 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
analog of oxazolam; structure
|
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-selectivity-class | AXL,EIF2AK3,GRK2,PDK4 | 4 | |||
| kinase-safety-class | ACVR2B,CDK5,EIF2AK3,GRK2,PDK1,PDK2,PDK4 | 7 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
None
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Drug dependence | 36.21 | 36.20 | 11 | 466 | 29316 | 90598654 |
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Altered state of consciousness | 39.86 | 30.64 | 14 | 579 | 57612 | 110531094 |
| Hepatic fibrosis | 33.86 | 30.64 | 8 | 585 | 8058 | 110580648 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | N05BA22 | NERVOUS SYSTEM PSYCHOLEPTICS ANXIOLYTICS Benzodiazepine derivatives |
| CHEBI has role | CHEBI:35474 | anxiolytic drug |
Related Drugs by ATC class:
N05BA Benzodiazepine derivatives 23 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 11.87 | acidic |
| pKa2 | 4.63 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Aldo-keto reductase family 1 member C3 | Enzyme | Ki | 5.82 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D01268 | KEGG_DRUG |
| 21311 | RXNORM |
| C0055964 | UMLSCUI |
| CHEBI:31426 | CHEBI |
| CHEMBL2107254 | ChEMBL_ID |
| DB01553 | DRUGBANK_ID |
| C005522 | MESH_SUPPLEMENTAL_RECORD_UI |
| 2816 | PUBCHEM_CID |
| 3400 | INN_ID |
| GYL649Z0HY | UNII |
| 006709 | NDDF |
| 16211000122103 | SNOMEDCT_US |
Pharmaceutical products:
None