diazepam 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
diazepam derivatives 852 439-14-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • RO-5-2807
  • diazepam
  • valium
A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.
  • Molecular weight: 284.74
  • Formula: C16H13ClN2O
  • CLOGP: 2.96
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 0
  • TPSA: 32.67
  • ALOGS: -4.37
  • ROTB: 1
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
10 mg O
10 mg P
10 mg R

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.06 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 2.01 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 99 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 1 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 0.38 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.02 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 42 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Nov. 15, 1963 FDA ROCHE

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug abuse 2394.41 9.59 1662 133816 58184 50411462
Toxicity to various agents 2062.30 9.59 2682 132796 209817 50259829
Completed suicide 1416.31 9.59 1753 133725 130136 50339510
Intentional overdose 1323.54 9.59 1194 134284 61310 50408336
Suicide attempt 947.65 9.59 912 134566 50820 50418826
Coma 695.99 9.59 809 134669 56070 50413576
Overdose 629.77 9.59 1030 134448 98697 50370949
Somnolence 560.51 9.59 1263 134215 153722 50315924
Respiratory arrest 551.00 9.59 530 134948 29479 50440167
Intentional self-injury 511.27 9.59 453 135025 22659 50446987
Drug withdrawal syndrome 500.65 9.59 464 135014 24617 50445029
Drug dependence 470.71 9.59 404 135074 19355 50450291
Sopor 454.43 9.59 397 135081 19482 50450164
Poisoning 453.84 9.59 327 135151 12102 50457544
Poisoning deliberate 390.93 9.59 251 135227 7661 50461985
Suicidal ideation 373.82 9.59 590 134888 54795 50414851
Intentional product misuse 333.71 9.59 511 134967 46223 50423423
Cardiac arrest 307.82 9.59 687 134791 82964 50386682
Cardio-respiratory arrest 300.53 9.59 527 134951 53365 50416281
Pemphigus 300.53 9.59 4 135474 120162 50349484
Rheumatoid arthritis 300.52 9.59 85 135393 202465 50267181
Agitation 295.06 9.59 520 134958 52864 50416782
Synovitis 280.16 9.59 12 135466 123853 50345793
Respiratory depression 274.75 9.59 240 135238 11770 50457876
Contraindicated product administered 274.30 9.59 37 135441 148921 50320725
Depressed level of consciousness 272.94 9.59 495 134983 51458 50418188
Infusion related reaction 271.07 9.59 61 135417 169496 50300150
Schizophrenia 252.77 9.59 187 135291 7210 50462436
Aggression 247.48 9.59 294 135184 20822 50448824
Systemic lupus erythematosus 242.77 9.59 42 135436 140580 50329066
Neuroleptic malignant syndrome 239.82 9.59 215 135263 10915 50458731
Joint swelling 234.34 9.59 188 135290 245098 50224548
Drug interaction 234.06 9.59 1106 134372 198515 50271131
Miosis 232.59 9.59 167 135311 6143 50463503
Psychotic disorder 220.64 9.59 282 135196 21530 50448116
Withdrawal syndrome 217.94 9.59 252 135226 17338 50452308
Treatment failure 216.99 9.59 51 135427 137586 50332060
Glossodynia 212.04 9.59 29 135449 115540 50354106
Drug intolerance 211.69 9.59 166 135312 218938 50250708
Serotonin syndrome 204.91 9.59 290 135188 24423 50445223
Arthropathy 193.92 9.59 90 135388 157816 50311830
Seizure 192.58 9.59 723 134755 117151 50352495
Drug ineffective 191.86 9.59 1348 134130 817985 49651661
Alopecia 186.69 9.59 229 135249 244818 50224828
Therapeutic product effect decreased 185.82 9.59 66 135412 135984 50333662
Disturbance in attention 185.63 9.59 314 135164 30872 50438774
Rash 177.22 9.59 591 134887 436880 50032766
Bradypnoea 170.62 9.59 105 135373 2969 50466677
Pericarditis 170.34 9.59 10 135468 78679 50390967
Tremor 169.93 9.59 683 134795 114220 50355426
Swelling 167.92 9.59 174 135304 200698 50268948
Peripheral swelling 161.55 9.59 188 135290 205748 50263898
Abdominal discomfort 160.59 9.59 232 135246 231409 50238237
Wound 157.51 9.59 44 135434 105750 50363896
Arthralgia 151.30 9.59 633 134845 438069 50031577
Anxiety 151.05 9.59 901 134577 176705 50292941
Nightmare 148.74 9.59 199 135279 15887 50453759
Hand deformity 143.10 9.59 45 135433 100154 50369492
Substance abuse 140.33 9.59 104 135374 4020 50465626
Tachycardia 138.78 9.59 582 134896 99181 50370465
Nasopharyngitis 134.89 9.59 192 135286 192735 50276911
Accidental overdose 132.95 9.59 209 135269 19324 50450322
Panic attack 131.71 9.59 207 135271 19135 50450511
Depression 131.66 9.59 825 134653 164598 50305048
Hypersensitivity 128.97 9.59 237 135241 214924 50254722
Discomfort 128.10 9.59 65 135413 108315 50361331
Mydriasis 124.56 9.59 148 135330 10479 50459167
Sinusitis 123.97 9.59 165 135313 170393 50299253
Muscle rigidity 123.74 9.59 142 135336 9687 50459959
Dissociation 121.44 9.59 76 135402 2215 50467431
Diarrhoea 121.23 9.59 1002 134476 587474 49882172
Sedation 116.53 9.59 255 135223 30355 50439291
Restlessness 116.16 9.59 227 135251 24946 50444700
Hypomania 115.23 9.59 96 135382 4409 50465237
Status epilepticus 110.64 9.59 157 135321 13249 50456397
Infection 110.44 9.59 183 135295 172771 50296875
Off label use 110.21 9.59 781 134697 473645 49996001
Bradyphrenia 109.73 9.59 107 135371 6045 50463601
Helicobacter infection 108.53 9.59 6 135472 49696 50419950
Anaemia 108.30 9.59 332 135146 252124 50217522
Drug withdrawal convulsions 106.49 9.59 58 135420 1295 50468351
Fatigue 103.56 9.59 1307 134171 706294 49763352
Hyperhidrosis 101.32 9.59 491 134987 88935 50380711
Stomatitis 100.02 9.59 75 135403 101269 50368377
Febrile neutropenia 99.36 9.59 70 135408 97597 50372049
Pain 98.35 9.59 1034 134444 577869 49891777
Dyskinesia 98.10 9.59 225 135253 27636 50442010
Derealisation 96.92 9.59 50 135428 996 50468650
Altered state of consciousness 95.58 9.59 193 135285 21717 50447929
Urinary retention 94.98 9.59 214 135264 25976 50443670
Exposure via ingestion 93.83 9.59 70 135408 2733 50466913
Duodenal ulcer perforation 92.35 9.59 8 135470 45603 50424043
Folliculitis 91.38 9.59 3 135475 39222 50430424
Salivary hypersecretion 91.14 9.59 100 135378 6491 50463155
Mood swings 90.14 9.59 157 135321 15797 50453849
Gastric pH decreased 89.57 9.59 41 135437 621 50469025
Cough 88.72 9.59 339 135139 240925 50228721
Asphyxia 88.68 9.59 90 135388 5337 50464309
Agoraphobia 88.40 9.59 34 135444 323 50469323
Depersonalisation/derealisation disorder 87.81 9.59 49 135429 1149 50468497
Feeling of despair 87.46 9.59 59 135419 1959 50467687
Mania 85.92 9.59 125 135353 10791 50458855
Cogwheel rigidity 84.39 9.59 55 135423 1722 50467924
Therapeutic product effect incomplete 83.72 9.59 73 135405 91442 50378204
Dysarthria 83.59 9.59 255 135223 37148 50432498
Irritability 83.43 9.59 214 135264 28212 50441434
Disorientation 83.15 9.59 246 135232 35238 50434408
Dystonia 83.09 9.59 129 135349 11797 50457849
Extrapyramidal disorder 82.97 9.59 128 135350 11642 50458004
Hypotonia 81.98 9.59 105 135373 8029 50461617
General physical health deterioration 80.82 9.59 162 135316 142272 50327374
Emotional disorder 78.27 9.59 125 135353 11711 50457935
Drooling 78.14 9.59 68 135410 3316 50466330
Dyspnoea 77.13 9.59 1019 134459 546589 49923057
Loss of consciousness 75.92 9.59 509 134969 103844 50365802
Product use issue 74.95 9.59 182 135296 149293 50320353
Muscle injury 73.81 9.59 7 135471 37104 50432542
Jaundice cholestatic 73.21 9.59 79 135399 5032 50464614
Hypothermia 72.83 9.59 122 135356 11894 50457752
Disease progression 71.40 9.59 91 135387 95775 50373871
Gastrointestinal disorder 71.03 9.59 89 135389 94367 50375279
Abnormal behaviour 70.58 9.59 160 135318 19498 50450148
Coma scale abnormal 70.55 9.59 75 135403 4696 50464950
Thrombocytopenia 70.06 9.59 148 135330 127525 50342121
Hepatic enzyme increased 68.30 9.59 168 135310 137212 50332434
Psychomotor hyperactivity 68.17 9.59 103 135375 9198 50460448
Speech disorder 67.32 9.59 229 135249 35319 50434327
Arthritis 65.96 9.59 81 135397 86640 50383006
Hallucinations, mixed 65.15 9.59 67 135411 4036 50465610
Accidental death 63.91 9.59 46 135432 1698 50467948
Hallucination, auditory 63.79 9.59 108 135370 10620 50459026
Tearfulness 63.66 9.59 63 135415 3624 50466022
Impaired healing 63.42 9.59 56 135422 69730 50399916
Hallucination 62.34 9.59 269 135209 46388 50423258
Lower respiratory tract infection 61.40 9.59 100 135378 95101 50374545
H1N1 influenza 60.54 9.59 43 135435 1554 50468092
Malignant neoplasm progression 60.32 9.59 56 135422 68068 50401578
Parkinsonism 59.28 9.59 94 135384 8753 50460893
Neutropenia 58.90 9.59 201 135277 147764 50321882
C-reactive protein abnormal 58.77 9.59 4 135474 27805 50441841
Respiratory acidosis 57.92 9.59 76 135402 5952 50463694
Generalised tonic-clonic seizure 57.50 9.59 178 135300 26132 50443514
Haemoglobin decreased 56.85 9.59 164 135314 127052 50342594
Dependence 56.54 9.59 44 135434 1831 50467815
Feeling of body temperature change 56.50 9.59 64 135414 4303 50465343
Anger 55.72 9.59 105 135373 11228 50458418
Myoglobin urine present 55.44 9.59 25 135453 365 50469281
Pruritus 53.59 9.59 493 134985 283075 50186571
Unresponsive to stimuli 53.47 9.59 192 135286 30417 50439229
Knee arthroplasty 53.15 9.59 15 135463 35831 50433815
Akathisia 51.82 9.59 85 135393 8144 50461502
Ataxia 51.50 9.59 114 135364 13672 50455974
Interstitial lung disease 50.36 9.59 41 135437 53135 50416511
Drug abuser 50.09 9.59 49 135429 2779 50466867
Multiple sclerosis 49.85 9.59 144 135334 20349 50449297
Developmental delay 49.42 9.59 35 135443 1259 50468387
Delirium 49.35 9.59 218 135260 37974 50431672
Depressed mood 49.22 9.59 201 135277 33822 50435824
Mucosal inflammation 49.03 9.59 23 135455 40119 50429527
Injection site pain 48.96 9.59 144 135334 110880 50358766
Immobilisation prolonged 48.95 9.59 16 135462 89 50469557
Platelet count decreased 48.63 9.59 125 135353 100601 50369045
Bone marrow failure 48.18 9.59 8 135470 27616 50442030
Lethargy 47.98 9.59 260 135218 49172 50420474
Self-injurious ideation 47.89 9.59 43 135435 2186 50467460
Pneumonia aspiration 47.12 9.59 186 135292 30818 50438828
Product dose omission issue 46.32 9.59 295 135183 183543 50286103
Victim of child abuse 45.90 9.59 10 135468 4 50469642
Multiple sclerosis relapse 45.85 9.59 232 135246 42732 50426914
Delusion 44.79 9.59 92 135386 10477 50459169
Reversible airways obstruction 44.63 9.59 30 135448 990 50468656
Drug withdrawal syndrome neonatal 44.55 9.59 38 135440 1803 50467843
Aspiration 44.51 9.59 85 135393 9179 50460467
Snoring 44.48 9.59 50 135428 3334 50466312
Psychomotor retardation 44.07 9.59 50 135428 3368 50466278
Electrocardiogram QT prolonged 43.85 9.59 263 135215 51623 50418023
Vision blurred 43.73 9.59 360 135118 78287 50391359
Mental disorder 43.70 9.59 144 135334 21847 50447799
Confusional state 43.35 9.59 719 134759 185209 50284437
Psychogenic seizure 43.10 9.59 35 135443 1550 50468096
Restless legs syndrome 42.89 9.59 116 135362 15781 50453865
Victim of sexual abuse 42.86 9.59 23 135455 498 50469148
Gastrointestinal haemorrhage 42.76 9.59 82 135396 73239 50396407
Blood creatine phosphokinase increased 42.37 9.59 161 135317 26206 50443440
Drowning 41.46 9.59 21 135457 402 50469244
Visceral congestion 41.20 9.59 19 135459 293 50469353
Hip arthroplasty 41.10 9.59 15 135463 30414 50439232
Psychomotor skills impaired 40.80 9.59 38 135440 2026 50467620
Urticaria 40.22 9.59 194 135284 129367 50340279
Neoplasm progression 40.02 9.59 14 135464 29143 50440503
Stiff person syndrome 39.95 9.59 17 135461 214 50469432
Paralysis 39.80 9.59 78 135400 8586 50461060
Vital capacity decreased 39.18 9.59 27 135451 929 50468717
Catatonia 38.87 9.59 49 135429 3687 50465959
Herpes zoster 38.86 9.59 82 135396 70704 50398942
Fluid retention 38.83 9.59 47 135431 50602 50419044
Pleural effusion 38.61 9.59 102 135376 81352 50388294
Loss of personal independence in daily activities 38.58 9.59 81 135397 69969 50399677
Rhesus incompatibility 38.53 9.59 13 135465 81 50469565
Cyanosis 38.20 9.59 108 135370 15076 50454570
Parosmia 38.16 9.59 53 135425 4383 50465263
Irritable bowel syndrome 38.11 9.59 49 135429 51392 50418254
Pleurothotonus 38.09 9.59 30 135448 1271 50468375
Physical assault 38.05 9.59 26 135452 882 50468764
Hyperprolactinaemia 38.02 9.59 46 135432 3319 50466327
Pancreatic fibrosis 38.00 9.59 13 135465 85 50469561
Acute kidney injury 37.84 9.59 409 135069 227649 50241997
Renal ischaemia 37.81 9.59 22 135456 560 50469086
Device expulsion 37.61 9.59 15 135463 28807 50440839
Muscle disorder 37.46 9.59 52 135426 4298 50465348
Housebound 37.01 9.59 16 135462 210 50469436
Insomnia 36.71 9.59 665 134813 174200 50295446
Incontinence 36.66 9.59 82 135396 9903 50459743
Ill-defined disorder 36.56 9.59 56 135422 54598 50415048
Inflammation 36.48 9.59 60 135418 56852 50412794
Crying 36.45 9.59 129 135349 20287 50449359
Oropharyngeal pain 36.44 9.59 98 135380 77703 50391943
Swollen tongue 35.91 9.59 162 135316 28468 50441178
Hypotonia neonatal 35.86 9.59 26 135452 971 50468675
Paranoia 35.79 9.59 83 135395 10265 50459381
PO2 increased 35.55 9.59 24 135454 798 50468848
Hepatic necrosis 35.49 9.59 56 135422 5192 50464454
Atrial fibrillation 35.40 9.59 146 135332 101599 50368047
Right ventricular hypertrophy 35.19 9.59 22 135456 640 50469006
COVID-19 35.03 9.59 44 135434 46618 50423028
Pyrexia 34.92 9.59 764 134714 379439 50090207
Sensory loss 34.75 9.59 69 135409 7669 50461977
Drug diversion 34.68 9.59 23 135455 742 50468904
Balance disorder 34.47 9.59 314 135164 70276 50399370
Drug screen positive 34.42 9.59 44 135434 3358 50466288
Pancytopenia 34.20 9.59 113 135365 83917 50385729
Cytomegalovirus infection 34.15 9.59 4 135474 17958 50451688
Injection site reaction 33.72 9.59 51 135427 49981 50419665
Alcohol poisoning 33.40 9.59 32 135446 1768 50467878
Chemical submission 32.92 9.59 14 135464 176 50469470
Menstrual disorder 32.89 9.59 49 135429 4321 50465325
Blood pressure systolic increased 32.74 9.59 28 135450 35421 50434225
Feeling jittery 32.72 9.59 84 135394 11076 50458570
PCO2 increased 32.69 9.59 26 135452 1117 50468529
Injection site pruritus 32.59 9.59 36 135442 40375 50429271
Injection site erythema 32.45 9.59 98 135380 74838 50394808
Amnesia 31.83 9.59 208 135270 42052 50427594
Panic reaction 31.24 9.59 43 135435 3526 50466120
Hypotension 31.11 9.59 838 134640 234631 50235015
Autonomic nervous system imbalance 30.94 9.59 35 135443 2350 50467296
Blood creatinine increased 30.60 9.59 103 135375 76057 50393589
Memory impairment 30.53 9.59 336 135142 79024 50390622
Electroencephalogram abnormal 30.39 9.59 42 135436 3457 50466189
Mutism 30.38 9.59 27 135451 1354 50468292
Pyramidal tract syndrome 30.34 9.59 16 135462 334 50469312
Therapeutic product ineffective 30.29 9.59 26 135452 1244 50468402
Paraesthesia 30.25 9.59 471 135007 119772 50349874
Bronchial secretion retention 30.19 9.59 28 135450 1485 50468161
Flashback 30.14 9.59 12 135466 126 50469520
Dyspnoea exertional 30.13 9.59 57 135421 51176 50418470
Sleep disorder 30.13 9.59 259 135219 57024 50412622
Blood pH decreased 30.11 9.59 35 135443 2420 50467226
Right ventricular dilatation 30.06 9.59 23 135455 933 50468713
Cardiac failure congestive 30.03 9.59 120 135358 84262 50385384
Myoclonus 29.87 9.59 96 135382 14374 50455272
Sputum culture positive 29.83 9.59 27 135451 1387 50468259
Aphasia 29.79 9.59 153 135325 28341 50441305
Drug level increased 29.60 9.59 116 135362 19152 50450494
Social avoidant behaviour 29.60 9.59 37 135441 2760 50466886
Antipsychotic drug level increased 29.56 9.59 39 135439 3070 50466576
Diabetes insipidus 29.49 9.59 34 135444 2330 50467316
C-reactive protein increased 29.45 9.59 86 135392 66388 50403258
Hypersomnia 29.29 9.59 99 135379 15215 50454431
Urinary incontinence 29.17 9.59 151 135327 28057 50441589
Pain in extremity 29.01 9.59 535 134943 272330 50197316
Conversion disorder 28.91 9.59 28 135450 1568 50468078
Erythema 28.28 9.59 253 135225 146161 50323485
Treatment noncompliance 28.19 9.59 157 135321 29993 50439653
Posturing 28.15 9.59 17 135461 464 50469182
Calcium deficiency 28.01 9.59 22 135456 928 50468718
Psoriatic arthropathy 27.95 9.59 52 135426 46980 50422666
Sudden death 27.74 9.59 69 135409 8922 50460724
Abdominal pain 27.73 9.59 455 135023 235773 50233873
Urine osmolarity increased 27.67 9.59 11 135467 115 50469531
Generalised anxiety disorder 27.60 9.59 29 135449 1791 50467855
Nasal congestion 27.40 9.59 60 135418 51060 50418586
Urine sodium increased 27.29 9.59 10 135468 82 50469564
Somnambulism 27.22 9.59 48 135430 4876 50464770
Myocardial fibrosis 26.79 9.59 19 135459 685 50468961
Blood pressure fluctuation 26.66 9.59 34 135444 35789 50433857
Intentional product use issue 26.36 9.59 111 135367 76807 50392839
Wheezing 26.25 9.59 82 135396 61965 50407681
Tissue infiltration 25.98 9.59 17 135461 536 50469110
Cardiac failure 25.90 9.59 110 135368 75930 50393716
Abnormal dreams 25.88 9.59 69 135409 9308 50460338
Somatic delusion 25.62 9.59 17 135461 549 50469097
Autonomic dysreflexia 25.53 9.59 14 135464 317 50469329
Pulmonary fibrosis 25.52 9.59 17 135461 24420 50445226
Alcohol use 25.41 9.59 29 135449 1966 50467680
Hypokinesia 25.17 9.59 81 135397 12136 50457510
Bezoar 25.08 9.59 24 135454 1324 50468322
Amylase increased 25.08 9.59 49 135429 5381 50464265
Respiratory rate decreased 25.06 9.59 36 135442 3072 50466574
Suicidal behaviour 24.90 9.59 31 135447 2303 50467343
Patient uncooperative 24.87 9.59 11 135467 153 50469493
Impaired reasoning 24.86 9.59 9 135469 71 50469575
Tardive dyskinesia 24.75 9.59 58 135420 7221 50462425
Anticonvulsant drug level above therapeutic 24.66 9.59 16 135462 497 50469149
Cortisol increased 24.43 9.59 14 135464 346 50469300
Apnoea 24.23 9.59 56 135422 6910 50462736
Negativism 24.07 9.59 14 135464 356 50469290
Drug use disorder 23.92 9.59 35 135443 3037 50466609
Ventricular dyskinesia 23.78 9.59 10 135468 122 50469524
Blood osmolarity decreased 23.76 9.59 19 135459 823 50468823
Hypervolaemia 23.72 9.59 20 135458 25479 50444167
Rhesus antigen positive 23.64 9.59 10 135468 124 50469522
Rhabdomyolysis 23.51 9.59 182 135296 38845 50430801
Terminal dribbling 23.34 9.59 6 135472 11 50469635
Hypoxic-ischaemic encephalopathy 23.27 9.59 39 135439 3803 50465843
Upper respiratory tract infection 23.27 9.59 94 135384 65804 50403842
Thinking abnormal 23.05 9.59 67 135411 9500 50460146
Ductus arteriosus premature closure 22.99 9.59 13 135465 313 50469333
Basal ganglion degeneration 22.80 9.59 14 135464 394 50469252
Pulmonary arterial hypertension 22.80 9.59 13 135465 20306 50449340
Productive cough 22.74 9.59 69 135409 52625 50417021
Adverse drug reaction 22.65 9.59 74 135404 55148 50414498
Hyperthermia 22.64 9.59 58 135420 7638 50462008
Hypotensive crisis 22.54 9.59 7 135471 32 50469614
Hallucination, visual 22.45 9.59 96 135382 16486 50453160
Injection site swelling 22.41 9.59 49 135429 41724 50427922
Bronchitis 22.36 9.59 175 135303 103984 50365662
Apathy 22.32 9.59 57 135421 7491 50462155
Sensory disturbance 22.21 9.59 76 135402 11753 50457893
Toxic encephalopathy 22.19 9.59 47 135431 5468 50464178
Basal cell carcinoma 22.12 9.59 18 135460 23338 50446308
Tooth hypoplasia 22.11 9.59 8 135470 63 50469583
Hospitalisation 22.09 9.59 100 135378 67837 50401809
Panic disorder 22.07 9.59 29 135449 2274 50467372
Feeling drunk 22.02 9.59 37 135441 3616 50466030
Negative symptoms in schizophrenia 21.99 9.59 9 135469 102 50469544
Pneumocystis jirovecii pneumonia 21.99 9.59 6 135472 14657 50454989
Affective disorder 21.84 9.59 45 135433 5136 50464510
Lactic acidosis 21.53 9.59 35 135443 33320 50436326
Hepatic steatosis 21.50 9.59 125 135353 24259 50445387
Hyperkalaemia 21.46 9.59 62 135416 48027 50421619
Sepsis 21.38 9.59 240 135238 132685 50336961
Adverse event 21.35 9.59 54 135424 43709 50425937
Bone erosion 21.26 9.59 3 135475 11684 50457962
Myelodysplastic syndrome 21.23 9.59 7 135471 15125 50454521
Stupor 21.21 9.59 36 135442 3547 50466099
Neonatal complications of substance abuse 21.18 9.59 5 135473 5 50469641
Blood sodium decreased 21.04 9.59 112 135366 21035 50448611
Spleen congestion 21.03 9.59 9 135469 115 50469531
Skin ulcer 21.03 9.59 39 135439 35279 50434367
Therapeutic response decreased 21.00 9.59 61 135417 47170 50422476
Electrocardiogram QRS complex prolonged 20.88 9.59 45 135433 5299 50464347
Suspected counterfeit product 20.60 9.59 12 135466 306 50469340
Sinus tachycardia 20.50 9.59 112 135366 21242 50448404
Logorrhoea 20.34 9.59 28 135450 2296 50467350
Distractibility 20.32 9.59 13 135465 394 50469252
White blood cell count decreased 20.28 9.59 207 135271 116515 50353131
Oropharyngeal oedema 20.22 9.59 11 135467 245 50469401
Oral discomfort 20.14 9.59 57 135421 7960 50461686
Cerebrospinal fluid leakage 20.07 9.59 18 135460 914 50468732
Psoriasis 19.87 9.59 106 135372 68894 50400752
Marchiafava-Bignami disease 19.87 9.59 5 135473 8 50469638
Behaviour disorder 19.82 9.59 28 135450 2352 50467294
Emotional distress 19.74 9.59 138 135340 28525 50441121
Blood immunoglobulin M decreased 19.73 9.59 16 135462 707 50468939
Inadequate analgesia 19.71 9.59 29 135449 2529 50467117
Psychotic symptom 19.62 9.59 20 135458 1192 50468454
Electrocardiogram QRS complex shortened 19.56 9.59 13 135465 421 50469225
Incoherent 19.33 9.59 38 135440 4192 50465454
Ascites 19.29 9.59 42 135436 35819 50433827
Pallor 19.22 9.59 117 135361 23082 50446564
Neuropathy peripheral 19.20 9.59 166 135312 96591 50373055
Enterochromaffin cell hyperplasia 19.14 9.59 7 135471 57 50469589
Cholelithiasis 19.09 9.59 170 135308 37803 50431843
Distal intestinal obstruction syndrome 19.07 9.59 12 135466 353 50469293
Blister 19.04 9.59 142 135336 85276 50384370
Illogical thinking 19.04 9.59 7 135471 58 50469588
Injection site bruising 19.02 9.59 44 135434 36724 50432922
Hypergastrinaemia 19.00 9.59 8 135470 98 50469548
Pulmonary congestion 18.91 9.59 86 135392 15161 50454485
Primitive reflex test positive 18.84 9.59 5 135473 11 50469635
Alpha 1 microglobulin increased 18.73 9.59 7 135471 61 50469585
Bladder dilatation 18.71 9.59 16 135462 762 50468884
Movement disorder 18.66 9.59 95 135383 17537 50452109
Nausea 18.66 9.59 1631 133847 703767 49765879
Epilepsy 18.65 9.59 110 135368 21457 50448189
Defect conduction intraventricular 18.64 9.59 8 135470 103 50469543
Carcinoid tumour of the stomach 18.62 9.59 9 135469 155 50469491
Thymus disorder 18.57 9.59 10 135468 218 50469428
Tenosynovitis 18.56 9.59 3 135475 10562 50459084
Tinnitus 18.53 9.59 134 135344 27998 50441648
Asthenia 18.53 9.59 683 134795 318359 50151287
Psychiatric symptom 18.45 9.59 39 135439 4531 50465115
Injection site warmth 18.45 9.59 7 135471 13859 50455787
Road traffic accident 18.42 9.59 120 135358 24232 50445414
Osteonecrosis of jaw 18.42 9.59 37 135441 32489 50437157
Liver function test increased 18.34 9.59 25 135453 25581 50444065
Maternal exposure during pregnancy 18.32 9.59 309 135169 159469 50310177
Borderline personality disorder 18.30 9.59 15 135463 673 50468973
Emotional poverty 18.16 9.59 11 135467 302 50469344
Euphoric mood 18.02 9.59 36 135442 4019 50465627
Fear 18.00 9.59 82 135396 14467 50455179
Somatic symptom disorder 17.89 9.59 24 135454 1920 50467726
Foetal exposure during pregnancy 17.84 9.59 130 135348 27229 50442417
Neurosis 17.82 9.59 10 135468 237 50469409
Abortion spontaneous 17.81 9.59 55 135423 41717 50427929
Obstructive airways disorder 17.74 9.59 86 135392 15566 50454080
Cardiac death 17.69 9.59 13 135465 496 50469150
Cor pulmonale acute 17.62 9.59 11 135467 319 50469327
Sudden cardiac death 17.62 9.59 24 135454 1948 50467698
Congenital central nervous system anomaly 17.53 9.59 11 135467 322 50469324
Melaena 17.51 9.59 28 135450 26836 50442810
Gallbladder cholesterolosis 17.49 9.59 15 135463 717 50468929
Base excess 17.46 9.59 7 135471 75 50469571
Haematochezia 17.37 9.59 52 135426 39830 50429816
Illness anxiety disorder 17.37 9.59 8 135470 123 50469523
Coordination abnormal 17.36 9.59 69 135409 11465 50458181
Victim of chemical submission 17.24 9.59 10 135468 253 50469393
Potentiating drug interaction 17.10 9.59 34 135444 3782 50465864
Red blood cell sedimentation rate increased 17.06 9.59 33 135445 29383 50440263
Fungal infection 17.04 9.59 34 135444 29931 50439715
Cataract 16.99 9.59 67 135411 47233 50422413
Hepatotoxicity 16.98 9.59 128 135350 27098 50442548
Renal failure 16.95 9.59 193 135285 106440 50363206
Colitis 16.95 9.59 50 135428 38479 50431167
Femur fracture 16.93 9.59 48 135430 37416 50432230
Troponin increased 16.89 9.59 54 135424 8064 50461582
Diastolic hypotension 16.83 9.59 7 135471 83 50469563
Hypoaesthesia oral 16.82 9.59 65 135413 10663 50458983
Product use in unapproved indication 16.75 9.59 214 135264 115605 50354041
Tension 16.68 9.59 28 135450 2734 50466912
Foetal death 16.64 9.59 54 135424 8126 50461520
Fibromyalgia 16.61 9.59 63 135415 44915 50424731
Obsessive-compulsive disorder 16.49 9.59 31 135447 3309 50466337
Galactorrhoea 16.48 9.59 33 135445 3690 50465956
Suspected suicide 16.41 9.59 41 135437 5316 50464330
Brain injury 16.34 9.59 44 135434 5970 50463676
Newborn persistent pulmonary hypertension 16.34 9.59 8 135470 142 50469504
Muscle spasms 16.31 9.59 446 135032 125107 50344539
Wrong rate 16.29 9.59 6 135472 50 50469596
Nodule 16.23 9.59 13 135465 16990 50452656
Musculoskeletal stiffness 16.22 9.59 244 135234 128237 50341409
Hyperacusis 16.19 9.59 22 135456 1782 50467864
Disinhibition 16.18 9.59 15 135463 795 50468851
Leukopenia 16.15 9.59 110 135368 67418 50402228
Palmar-plantar erythrodysaesthesia syndrome 16.10 9.59 18 135460 20080 50449566
Sinus bradycardia 16.09 9.59 74 135404 13109 50456537
Withdrawal catatonia 15.98 9.59 6 135472 53 50469593
Hemiparesis 15.91 9.59 100 135378 19948 50449698
Illusion 15.84 9.59 16 135462 943 50468703
Rash pruritic 15.81 9.59 70 135408 47776 50421870
Drug hypersensitivity 15.79 9.59 532 134946 250478 50219168
Accidental poisoning 15.75 9.59 13 135465 589 50469057
Foaming at mouth 15.72 9.59 17 135461 1085 50468561
Thyroid adenoma 15.71 9.59 8 135470 155 50469491
Lack of spontaneous speech 15.71 9.59 8 135470 155 50469491
Death 15.70 9.59 1041 134437 324338 50145308
Abdominal tenderness 15.67 9.59 49 135429 7231 50462415
Periorbital swelling 15.51 9.59 22 135456 1855 50467791
Influenza 15.46 9.59 159 135319 89379 50380267
Haemodynamic instability 15.46 9.59 52 135426 7972 50461674
Vestibular disorder 15.41 9.59 18 135460 1251 50468395
Neutrophil count decreased 15.41 9.59 67 135411 45959 50423687
Toxicologic test abnormal 15.36 9.59 13 135465 610 50469036
Craniosynostosis 15.34 9.59 8 135470 163 50469483
Slow response to stimuli 15.28 9.59 15 135463 854 50468792
Asthma 15.28 9.59 159 135319 89178 50380468
Clonic convulsion 15.24 9.59 13 135465 617 50469029
Clostridium difficile colitis 15.21 9.59 15 135463 17727 50451919
Sensation of foreign body 15.21 9.59 33 135445 3903 50465743
Tongue movement disturbance 15.19 9.59 9 135469 237 50469409
Oculogyric crisis 15.19 9.59 19 135459 1418 50468228
Lupus hepatitis 15.12 9.59 5 135473 29 50469617
Hypercapnic coma 15.08 9.59 8 135470 169 50469477
Muscle tightness 15.08 9.59 61 135417 10219 50459427
Gait deviation 15.07 9.59 6 135472 63 50469583
Acute myeloid leukaemia 15.06 9.59 11 135467 15063 50454583
Mobility decreased 15.05 9.59 139 135339 79809 50389837
Oedema 15.02 9.59 118 135360 70063 50399583
Mental impairment 14.99 9.59 68 135410 11976 50457670
Myocarditis septic 14.98 9.59 5 135473 30 50469616
Persistent depressive disorder 14.97 9.59 15 135463 876 50468770
Tongue discolouration 14.93 9.59 27 135451 2797 50466849
Alcoholism 14.91 9.59 20 135458 1600 50468046
Medication error 14.87 9.59 155 135323 35949 50433697
Morbid thoughts 14.80 9.59 12 135466 530 50469116
Waxy flexibility 14.78 9.59 7 135471 115 50469531
Cyclothymic disorder 14.74 9.59 6 135472 67 50469579
Pain in jaw 14.74 9.59 53 135425 38375 50431271
Facial nerve disorder 14.73 9.59 12 135466 534 50469112
Bundle branch block right 14.70 9.59 36 135442 4609 50465037
Atrioventricular septal defect 14.70 9.59 9 135469 252 50469394
Benzodiazepine drug level increased 14.67 9.59 8 135470 179 50469467
Dyspraxia 14.64 9.59 9 135469 254 50469392
Blood pressure diastolic decreased 14.61 9.59 14 135464 16767 50452879
Feeling abnormal 14.43 9.59 439 135039 125053 50344593
Localised infection 14.42 9.59 29 135449 25456 50444190
Sputum discoloured 14.42 9.59 9 135469 13386 50456260
Anaesthesia 14.36 9.59 10 135468 350 50469296
Blood bicarbonate decreased 14.34 9.59 26 135452 2699 50466947
Gastrointestinal motility disorder 14.33 9.59 35 135443 4474 50465172
Hypoventilation 14.17 9.59 32 135446 3889 50465757
Poor venous access 14.13 9.59 5 135473 10335 50459311
Judgement impaired 14.07 9.59 12 135466 569 50469077
Blood sodium increased 14.04 9.59 24 135454 2378 50467268
Body temperature decreased 13.90 9.59 14 135464 16381 50453265
Rhinorrhoea 13.90 9.59 81 135397 51502 50418144
Hypertonia 13.89 9.59 32 135446 3941 50465705
Extravascular haemolysis 13.86 9.59 5 135473 39 50469607
Alcohol abuse 13.86 9.59 21 135457 1880 50467766
Cholinergic syndrome 13.83 9.59 10 135468 372 50469274
Cellulitis 13.81 9.59 122 135356 70676 50398970
Needle track marks 13.72 9.59 4 135474 14 50469632
Congenital hand malformation 13.63 9.59 9 135469 288 50469358
Partial seizures 13.63 9.59 36 135442 4829 50464817
Dysphagia 13.60 9.59 287 135191 77231 50392415
Circulatory collapse 13.60 9.59 96 135382 19904 50449742
Drug-device interaction 13.53 9.59 6 135472 84 50469562
Bruxism 13.52 9.59 27 135451 3013 50466633
Clostridium difficile infection 13.51 9.59 30 135448 25409 50444237
Perforation bile duct 13.51 9.59 4 135474 15 50469631
Epistaxis 13.47 9.59 108 135370 63846 50405800
Nystagmus 13.45 9.59 39 135439 5522 50464124
Formication 13.45 9.59 30 135448 3616 50466030
Poor sucking reflex 13.39 9.59 8 135470 214 50469432
Drug detoxification 13.37 9.59 7 135471 144 50469502
Delirium tremens 13.34 9.59 6 135472 87 50469559
Gastric lavage 13.24 9.59 5 135473 45 50469601
Dehydration 13.19 9.59 309 135169 152140 50317506
Lactate pyruvate ratio increased 13.16 9.59 6 135472 90 50469556
Personality disorder 13.15 9.59 33 135445 4291 50465355
Hyperventilation 13.14 9.59 38 135440 5371 50464275
Abscess sterile 13.14 9.59 5 135473 46 50469600
Device difficult to use 13.14 9.59 5 135473 9881 50459765
Labelled drug-food interaction issue 13.12 9.59 4 135474 17 50469629
Metastases to liver 13.06 9.59 21 135457 20083 50449563
Progressive supranuclear palsy 13.05 9.59 5 135473 47 50469599
Pneumonia 12.95 9.59 856 134622 377545 50092101
Osteoporosis 12.89 9.59 69 135409 44810 50424836
Cardiac arrest neonatal 12.87 9.59 6 135472 95 50469551
Clonus 12.84 9.59 32 135446 4143 50465503
Uterine enlargement 12.75 9.59 15 135463 1051 50468595
Major depression 12.72 9.59 44 135434 6840 50462806
Exposure to unspecified agent 12.71 9.59 3 135475 3 50469643
Prescription drug used without a prescription 12.70 9.59 19 135459 1681 50467965
Kidney enlargement 12.70 9.59 11 135467 533 50469113
Delusion of reference 12.65 9.59 6 135472 99 50469547
Brain oedema 12.64 9.59 66 135412 12304 50457342
Inappropriate schedule of product administration 12.63 9.59 127 135351 71704 50397942
Encephalopathy 12.62 9.59 142 135336 33569 50436077
Apgar score low 12.60 9.59 12 135466 658 50468988
Porphyria 12.59 9.59 7 135471 163 50469483
Choreoathetosis 12.55 9.59 10 135468 431 50469215
Neurological decompensation 12.38 9.59 22 135456 2248 50467398
Substance use 12.30 9.59 9 135469 341 50469305
Muscle twitching 12.26 9.59 77 135401 15354 50454292
Adrenal insufficiency 12.26 9.59 12 135466 14231 50455415
Vertigo 12.26 9.59 201 135277 51631 50418015
Hyperchloraemia 12.14 9.59 12 135466 689 50468957
Plasma cell myeloma 12.14 9.59 43 135435 31279 50438367
Head titubation 12.11 9.59 12 135466 691 50468955
Hereditary angioedema 12.06 9.59 37 135441 5405 50464241
Blood citric acid increased 12.04 9.59 5 135473 59 50469587
Hostility 12.03 9.59 19 135459 1763 50467883
Oxygen saturation abnormal 12.02 9.59 24 135454 2678 50466968
Eye irritation 12.01 9.59 17 135461 17123 50452523
Drug level above therapeutic 12.01 9.59 30 135448 3890 50465756
Central nervous system stimulation 11.98 9.59 4 135474 24 50469622
Tuberculosis 11.97 9.59 6 135472 10077 50459569
Victim of homicide 11.96 9.59 5 135473 60 50469586
Brief psychotic disorder with marked stressors 11.96 9.59 5 135473 60 50469586
Right ventricular failure 11.91 9.59 15 135463 15878 50453768
Implant site extravasation 11.90 9.59 10 135468 465 50469181
Uveitis 11.89 9.59 5 135473 9305 50460341
Congenital nystagmus 11.85 9.59 3 135475 5 50469641
Eczema eyelids 11.84 9.59 6 135472 115 50469531
Live birth 11.77 9.59 16 135462 16392 50453254
Arteriosclerosis coronary artery 11.75 9.59 46 135432 7590 50462056
Trismus 11.74 9.59 27 135451 3321 50466325
Intestinal infarction 11.70 9.59 14 135464 998 50468648
Nervous system disorder 11.70 9.59 79 135399 16144 50453502
Heart rate increased 11.67 9.59 280 135198 76970 50392676
Eosinophilia 11.64 9.59 20 135458 18632 50451014
Body mass index decreased 11.64 9.59 9 135469 371 50469275
Blood albumin increased 11.62 9.59 13 135465 862 50468784
Renal impairment 11.61 9.59 138 135340 75523 50394123
Peritoneal perforation 11.61 9.59 6 135472 120 50469526
Gaze palsy 11.58 9.59 16 135462 1317 50468329
Decreased interest 11.56 9.59 25 135453 2951 50466695
Chronic kidney disease 11.50 9.59 61 135417 39710 50429936
Bacteraemia 11.48 9.59 13 135465 14420 50455226
Radial nerve palsy 11.47 9.59 10 135468 489 50469157
Frontotemporal dementia 11.41 9.59 8 135470 283 50469363
Osteoarthritis 11.37 9.59 123 135355 68483 50401163
Blood pressure diastolic increased 11.25 9.59 3 135475 7440 50462206
Otospondylomegaepiphyseal dysplasia 11.21 9.59 5 135473 71 50469575
Camptocormia 11.17 9.59 8 135470 293 50469353
Moaning 11.15 9.59 12 135466 762 50468884
Heart rate decreased 11.11 9.59 55 135423 36442 50433204
Pupil fixed 11.11 9.59 17 135461 1535 50468111
Unmasking of previously unidentified disease 11.10 9.59 12 135466 766 50468880
Antipsychotic drug level decreased 11.09 9.59 7 135471 207 50469439
Reticulocytosis 11.01 9.59 6 135472 134 50469512
Condition aggravated 11.01 9.59 667 134811 296391 50173255
Food allergy 11.01 9.59 4 135474 8133 50461513
Hyporeflexia 10.99 9.59 18 135460 1722 50467924
Regressive behaviour 10.97 9.59 5 135473 75 50469571
Purpura senile 10.96 9.59 10 135468 519 50469127
Myelosuppression 10.94 9.59 12 135466 13505 50456141
Type 2 diabetes mellitus 10.93 9.59 51 135427 34324 50435322
Cholestasis 10.91 9.59 110 135368 25291 50444355
Snake bite 10.90 9.59 3 135475 8 50469638
Intellectual disability 10.90 9.59 12 135466 782 50468864
Ventricular arrhythmia 10.85 9.59 26 135452 3283 50466363
Skin reaction 10.85 9.59 9 135469 11559 50458087
Poor quality sleep 10.80 9.59 79 135399 16567 50453079
Thrombotic microangiopathy 10.79 9.59 5 135473 8786 50460860
Left ventricular hypertrophy 10.79 9.59 33 135445 4812 50464834
Skin necrosis 10.77 9.59 8 135470 10859 50458787
Lupus-like syndrome 10.75 9.59 6 135472 9485 50460161
Poverty of speech 10.71 9.59 8 135470 313 50469333
Alcohol interaction 10.71 9.59 20 135458 2124 50467522
Rectal haemorrhage 10.68 9.59 60 135418 38498 50431148
Nervousness 10.59 9.59 117 135361 27534 50442112
Ulcer 10.59 9.59 24 135454 20176 50449470
Coeliac disease 10.57 9.59 5 135473 8680 50460966
Toxic epidermal necrolysis 10.56 9.59 94 135384 20898 50448748
Oromandibular dystonia 10.48 9.59 9 135469 431 50469215
Pneumonitis 10.47 9.59 42 135436 29468 50440178
Haemophagocytic lymphohistiocytosis 10.46 9.59 5 135473 8628 50461018
Neonatal disorder 10.45 9.59 10 135468 552 50469094
Breathing-related sleep disorder 10.40 9.59 5 135473 85 50469561
Areflexia 10.39 9.59 23 135455 2757 50466889
Monoplegia 10.38 9.59 23 135455 2760 50466886
Persecutory delusion 10.38 9.59 21 135457 2366 50467280
Automatic bladder 10.35 9.59 5 135473 86 50469560
Strabismus 10.32 9.59 18 135460 1812 50467834
Hyperchromic anaemia 10.31 9.59 4 135474 39 50469607
Faecaloma 10.28 9.59 42 135436 7066 50462580
Body temperature increased 10.26 9.59 46 135432 31295 50438351
Joint stiffness 10.22 9.59 44 135434 30264 50439382
Thrombosis 10.11 9.59 98 135380 55735 50413911
Resorption bone increased 10.11 9.59 13 135465 998 50468648
Anxiety disorder 10.11 9.59 27 135451 3646 50466000
Immunodeficiency 10.10 9.59 15 135463 14813 50454833
Anticonvulsant drug level decreased 10.09 9.59 14 135464 1157 50468489
Electrocardiogram ST segment elevation 10.04 9.59 26 135452 3447 50466199
Substance use disorder 10 9.59 5 135473 93 50469553
Intervertebral disc disorder 9.99 9.59 30 135448 4330 50465316
Lid lag 9.98 9.59 3 135475 12 50469634
Pupillary reflex impaired 9.97 9.59 18 135460 1863 50467783
COVID-19 pneumonia 9.96 9.59 5 135473 8390 50461256
Therapy non-responder 9.91 9.59 88 135390 50934 50418712
Bradykinesia 9.87 9.59 28 135450 3915 50465731
Myofascial pain syndrome 9.87 9.59 19 135459 2064 50467582
Transfusion 9.86 9.59 12 135466 12893 50456753
Quadriparesis 9.84 9.59 17 135461 1699 50467947
Taste disorder 9.81 9.59 5 135473 8319 50461327
Hip fracture 9.79 9.59 36 135442 25895 50443751
Cardiotoxicity 9.76 9.59 41 135437 6986 50462660
Hypermagnesaemia 9.74 9.59 12 135466 882 50468764
Duodenal ulcer 9.74 9.59 3 135475 6772 50462874
Anaphylactic reaction 9.74 9.59 95 135383 53960 50415686
Therapy interrupted 9.72 9.59 25 135453 20127 50449519
Hyperreflexia 9.71 9.59 33 135445 5085 50464561
Angioedema 9.71 9.59 60 135418 37616 50432030
Torticollis 9.70 9.59 17 135461 1719 50467927
Colitis ulcerative 9.69 9.59 19 135459 16835 50452811
Ovarian cyst 9.69 9.59 14 135464 13982 50455664
Muscle contractions involuntary 9.69 9.59 18 135460 1904 50467742
Anticonvulsant drug level increased 9.68 9.59 15 135463 1369 50468277
Septic shock 9.67 9.59 102 135376 57073 50412573
Loss of libido 9.62 9.59 14 135464 1209 50468437
Blood pressure increased 9.61 9.59 277 135201 132855 50336791
Phalangeal hypoplasia 9.61 9.59 3 135475 14 50469632
Congenital scoliosis 9.61 9.59 3 135475 14 50469632

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug abuse 3544.04 10.77 2536 93029 77347 29401615
Toxicity to various agents 3340.21 10.77 3406 92159 170255 29308707
Overdose 885.92 10.77 1186 94379 78633 29400329
Coma 872.05 10.77 839 94726 38611 29440351
Drug dependence 719.13 10.77 573 94992 20408 29458554
Intentional overdose 707.23 10.77 741 94824 37787 29441175
Poisoning 698.30 10.77 423 95142 9570 29469392
Completed suicide 676.95 10.77 1116 94449 89130 29389832
Respiratory arrest 554.63 10.77 541 95024 25292 29453670
Somnolence 554.42 10.77 1046 94519 92909 29386053
Intentional product misuse 495.24 10.77 585 94980 34076 29444886
Suicide attempt 487.85 10.77 576 94989 33534 29445428
Substance abuse 373.30 10.77 247 95318 6540 29472422
Accidental overdose 345.26 10.77 351 95214 17242 29461720
Aggression 333.58 10.77 488 95077 35053 29443909
Miosis 320.64 10.77 240 95325 7769 29471193
Respiratory depression 318.14 10.77 298 95267 13225 29465737
Agitation 290.72 10.77 562 95003 50742 29428220
Poisoning deliberate 289.85 10.77 198 95367 5533 29473429
Drug withdrawal syndrome 269.12 10.77 311 95254 17673 29461289
Cardio-respiratory arrest 234.29 10.77 510 95055 50091 29428871
Diarrhoea 232.60 10.77 453 95112 332245 29146717
Intentional self-injury 227.12 10.77 239 95326 12222 29466740
Suicidal ideation 222.44 10.77 401 95164 34315 29444647
Bradypnoea 220.64 10.77 121 95444 2250 29476712
Febrile neutropenia 220.17 10.77 47 95518 112193 29366769
Pneumonia aspiration 219.83 10.77 412 95153 36325 29442637
Depressed level of consciousness 210.79 10.77 406 95159 36536 29442426
Cardiac arrest 209.17 10.77 680 94885 84911 29394051
Sedation 208.48 10.77 269 95296 17136 29461826
Sopor 206.96 10.77 214 95351 10720 29468242
Drug interaction 171.27 10.77 1157 94408 196228 29282734
Asphyxia 166.82 10.77 138 95427 5177 29473785
Neuroleptic malignant syndrome 163.53 10.77 230 95335 15918 29463044
Withdrawal syndrome 160.92 10.77 188 95377 10804 29468158
Drug abuser 147.21 10.77 112 95453 3715 29475247
Bradyphrenia 144.04 10.77 115 95450 4099 29474863
Anaemia 142.28 10.77 271 95294 200680 29278282
Restlessness 136.98 10.77 252 95313 21893 29457069
Coma scale abnormal 132.29 10.77 101 95464 3368 29475594
Dysarthria 131.13 10.77 301 95264 30610 29448352
Acute kidney injury 130.80 10.77 431 95134 264836 29214126
Pneumonia 124.14 10.77 573 94992 319599 29159363
Psychotic disorder 118.87 10.77 226 95339 20128 29458834
Drug use disorder 118.27 10.77 94 95471 3328 29475634
Dyspnoea 114.42 10.77 606 94959 326126 29152836
Malignant neoplasm progression 113.87 10.77 48 95517 73811 29405151
Visceral congestion 112.32 10.77 47 95518 461 29478501
Rash 112.04 10.77 283 95282 189536 29289426
Housebound 111.93 10.77 38 95527 194 29478768
Altered state of consciousness 110.23 10.77 216 95349 19673 29459289
Loss of consciousness 106.63 10.77 498 95067 73558 29405404
Prescription drug used without a prescription 106.26 10.77 61 95504 1243 29477719
Logorrhoea 106.19 10.77 75 95490 2213 29476749
Salivary hypersecretion 103.94 10.77 124 95441 7285 29471677
Abnormal behaviour 103.42 10.77 230 95335 22897 29456065
Accidental death 101.96 10.77 71 95494 2047 29476915
Anxiety 100.98 10.77 543 95022 84822 29394140
Thrombocytopenia 95.14 10.77 182 95383 134641 29344321
Brain oedema 93.79 10.77 153 95412 12067 29466895
Delirium 92.49 10.77 309 95256 39088 29439874
Mydriasis 92.28 10.77 106 95459 5979 29472983
Pancytopenia 91.99 10.77 80 95485 83088 29395874
Cough 91.23 10.77 169 95396 126558 29352404
Sepsis 89.43 10.77 206 95359 142476 29336486
Pulmonary congestion 89.14 10.77 151 95414 12285 29466677
Atrial fibrillation 88.05 10.77 128 95437 105518 29373444
Cardiac failure congestive 87.97 10.77 71 95494 76510 29402452
Disease progression 87.96 10.77 81 95484 81835 29397127
Drug screen positive 85.99 10.77 82 95483 3719 29475243
Extrapyramidal disorder 83.65 10.77 136 95429 10695 29468267
Seizure 82.94 10.77 550 95015 92573 29386389
Disturbance in attention 82.57 10.77 201 95364 21223 29457739
Interstitial lung disease 82.00 10.77 42 95523 57676 29421286
Arthralgia 81.64 10.77 209 95356 139408 29339554
Fatigue 81.07 10.77 646 94919 316175 29162787
Off label use 80.86 10.77 605 94960 300195 29178767
Hypothermia 79.64 10.77 122 95443 9117 29469845
Nausea 78.58 10.77 580 94985 288675 29190287
Confusional state 78.43 10.77 692 94873 127185 29351777
Delusion 77.51 10.77 134 95431 11082 29467880
Pulmonary oedema 76.51 10.77 307 95258 42428 29436534
Pyrexia 74.68 10.77 584 94981 287038 29191924
Alcohol poisoning 72.48 10.77 68 95497 3021 29475941
Suicidal behaviour 71.00 10.77 48 95517 1317 29477645
Bradykinesia 69.82 10.77 70 95495 3377 29475585
Electrocardiogram QT prolonged 67.42 10.77 263 95302 35874 29443088
COVID-19 66.72 10.77 17 95548 35997 29442965
Exposure via ingestion 66.69 10.77 54 95511 1964 29476998
Alcohol abuse 66.58 10.77 76 95489 4257 29474705
Dystonia 65.45 10.77 115 95450 9634 29469328
Disorientation 64.44 10.77 226 95339 29289 29449673
Mood swings 62.85 10.77 96 95469 7155 29471807
Infusion related reaction 62.23 10.77 32 95533 43854 29435108
Haemoglobin decreased 61.96 10.77 164 95401 108211 29370751
Thinking abnormal 61.23 10.77 80 95485 5156 29473806
Irritability 58.55 10.77 181 95384 21971 29456991
Joint swelling 58.25 10.77 45 95520 49585 29429377
Abdominal pain 57.24 10.77 234 95331 135123 29343839
Platelet count decreased 57.14 10.77 162 95403 104510 29374452
Anger 56.41 10.77 115 95450 10775 29468187
Peripheral swelling 56.31 10.77 74 95491 63665 29415297
Dyspnoea exertional 55.75 10.77 24 95541 36466 29442496
Schizophrenia 55.61 10.77 86 95479 6479 29472483
Weight decreased 54.21 10.77 277 95288 150628 29328334
Mental impairment 53.98 10.77 102 95463 9039 29469923
Akathisia 53.89 10.77 86 95479 6656 29472306
Depression 53.82 10.77 464 95101 84683 29394279
Drug withdrawal convulsions 53.74 10.77 38 95527 1123 29477839
Paranoia 53.18 10.77 106 95459 9771 29469191
Sudden death 52.89 10.77 131 95434 13979 29464983
General physical health deterioration 52.67 10.77 164 95401 102693 29376269
Status epilepticus 52.41 10.77 111 95454 10683 29468279
Aspiration 52.13 10.77 107 95458 10073 29468889
Product dose omission issue 51.99 10.77 150 95415 96233 29382729
Cytomegalovirus infection 51.44 10.77 7 95558 23208 29455754
Renal impairment 51.24 10.77 117 95448 81216 29397746
Postmortem blood drug level abnormal 51.17 10.77 23 95542 272 29478690
Decreased appetite 50.95 10.77 269 95296 145073 29333889
Tremor 50.88 10.77 409 95156 73129 29405833
Antipsychotic drug level increased 50.03 10.77 57 95508 3186 29475776
International normalised ratio increased 49.87 10.77 42 95523 44330 29434632
Pleural effusion 49.85 10.77 98 95467 71810 29407152
Rheumatoid arthritis 49.35 10.77 21 95544 32131 29446831
Echolalia 49.34 10.77 22 95543 255 29478707
Pruritus 48.76 10.77 203 95362 116646 29362316
Oedema peripheral 48.30 10.77 172 95393 103385 29375577
Serotonin syndrome 48.07 10.77 145 95420 17367 29461595
Panic attack 48.04 10.77 92 95473 8234 29470728
Mucosal inflammation 47.92 10.77 21 95544 31574 29447388
Self-medication 47.84 10.77 46 95519 2108 29476854
Tachycardia 46.48 10.77 396 95169 72014 29406948
Psychomotor hyperactivity 46.47 10.77 90 95475 8123 29470839
Toxicologic test abnormal 46.30 10.77 26 95539 507 29478455
Infection 46.28 10.77 113 95452 76638 29402324
Product use in unapproved indication 46.27 10.77 136 95429 86739 29392223
Insomnia 46.19 10.77 464 95101 88297 29390665
Nasopharyngitis 46.12 10.77 76 95489 59589 29419373
Gastrointestinal haemorrhage 45.71 10.77 120 95445 79413 29399549
Dehydration 45.64 10.77 203 95362 114545 29364417
Hypertonia 45.55 10.77 59 95506 3770 29475192
Memory impairment 45.12 10.77 235 95330 36235 29442727
Psychotic behaviour 44.68 10.77 27 95538 607 29478355
Nystagmus 44.54 10.77 62 95503 4247 29474715
Alcohol interaction 44.25 10.77 49 95516 2654 29476308
Self-injurious ideation 44.00 10.77 38 95527 1513 29477449
Asthenia 43.99 10.77 464 95101 214786 29264176
Generalised tonic-clonic seizure 43.90 10.77 149 95416 18990 29459972
Epilepsy 43.61 10.77 145 95420 18287 29460675
Ascites 43.23 10.77 33 95532 36586 29442376
Stomatitis 43.11 10.77 34 95531 37079 29441883
Nightmare 42.79 10.77 106 95459 11311 29467651
Cerebrovascular accident 42.72 10.77 118 95447 76793 29402169
Epistaxis 42.69 10.77 63 95502 51641 29427321
Pneumonitis 41.96 10.77 19 95546 28025 29450937
Prostate cancer 41.94 10.77 15 95550 25512 29453450
Coordination abnormal 41.53 10.77 79 95486 7035 29471927
Tension 40.88 10.77 40 95525 1873 29477089
Drug intolerance 40.87 10.77 58 95507 48321 29430641
Neutropenia 40.65 10.77 254 95311 131457 29347505
Hallucination, auditory 40.20 10.77 93 95472 9500 29469462
Renal failure 40.17 10.77 222 95343 118377 29360585
Arteriosclerosis coronary artery 39.26 10.77 98 95467 10507 29468455
Rhabdomyolysis 39.26 10.77 333 95232 60475 29418487
Psychotic symptom 38.81 10.77 34 95531 1380 29477582
Drug diversion 38.48 10.77 27 95538 788 29478174
Colitis 38.39 10.77 27 95538 31221 29447741
Emotional disorder 38.18 10.77 62 95503 4869 29474093
Drug ineffective 38.10 10.77 889 94676 362281 29116681
Cardiac failure 38.09 10.77 130 95435 79157 29399805
Pneumocystis jirovecii pneumonia 37.31 10.77 5 95560 16774 29462188
Hyperhidrosis 37.31 10.77 345 95220 64195 29414767
Hypotonia 37.07 10.77 74 95491 6828 29472134
Sinus tachycardia 36.96 10.77 120 95445 14949 29464013
Haematochezia 36.87 10.77 39 95526 36944 29442018
Drug withdrawal syndrome neonatal 36.82 10.77 50 95515 3345 29475617
Myocardial infarction 36.51 10.77 208 95357 110088 29368874
Chills 36.26 10.77 114 95451 71186 29407776
Opiates positive 36.19 10.77 22 95543 500 29478462
Haematuria 35.26 10.77 55 95510 44084 29434878
Behaviour disorder 34.38 10.77 50 95515 3566 29475396
Erythema 34.29 10.77 127 95438 75479 29403483
Acute myeloid leukaemia 34.26 10.77 6 95559 16507 29462455
Plasma cell myeloma 33.89 10.77 42 95523 37073 29441889
Muscle rigidity 33.83 10.77 86 95479 9325 29469637
Drug detoxification 33.71 10.77 15 95550 173 29478789
Encephalitis toxic 33.38 10.77 17 95548 270 29478692
Hypoxic-ischaemic encephalopathy 33.36 10.77 54 95511 4230 29474732
Unresponsive to stimuli 31.83 10.77 163 95402 24963 29453999
Poor quality sleep 31.27 10.77 71 95494 7162 29471800
Hypervolaemia 31.14 10.77 9 95556 17536 29461426
Hypoventilation 31.05 10.77 42 95523 2799 29476163
Homicide 31.02 10.77 25 95540 903 29478059
Mental disorder 30.96 10.77 102 95463 12803 29466159
Postmortem blood drug level increased 30.76 10.77 15 95550 216 29478746
Blood pressure fluctuation 30.52 10.77 13 95552 19881 29459081
Angioedema 30.33 10.77 35 95530 31880 29447082
Vestibular disorder 30.26 10.77 26 95539 1028 29477934
Ataxia 30.24 10.77 97 95468 12006 29466956
Psychomotor skills impaired 30.10 10.77 40 95525 2621 29476341
Agoraphobia 30.09 10.77 15 95550 227 29478735
Blood pressure increased 29.67 10.77 130 95435 73673 29405289
Anterograde amnesia 29.52 10.77 13 95552 146 29478816
Brain injury 29.49 10.77 59 95506 5453 29473509
Acute myocardial infarction 29.43 10.77 71 95494 48367 29430595
Palmar-plantar erythrodysaesthesia syndrome 29.26 10.77 6 95559 14753 29464209
Neuropathy peripheral 29.23 10.77 124 95441 70903 29408059
Bronchopulmonary aspergillosis 29.13 10.77 3 95562 12341 29466621
Tumour lysis syndrome 28.90 10.77 5 95560 13879 29465083
Pupillary disorder 28.54 10.77 15 95550 255 29478707
Chronic kidney disease 28.49 10.77 46 95519 36370 29442592
Acute psychosis 28.34 10.77 31 95534 1656 29477306
Myelodysplastic syndrome 28.32 10.77 11 95554 17783 29461179
Chest discomfort 28.26 10.77 67 95498 45916 29433046
Cerebral haemorrhage 28.24 10.77 36 95529 31390 29447572
Facial spasm 27.70 10.77 13 95552 171 29478791
Dizziness 27.57 10.77 439 95126 189245 29289717
Amnesia 27.37 10.77 145 95420 22498 29456464
Clostridium difficile infection 27.35 10.77 9 95556 16132 29462830
Bladder dilatation 27.30 10.77 27 95538 1281 29477681
Bone marrow failure 27.30 10.77 29 95536 27420 29451542
Cerebral congestion 26.89 10.77 8 95557 24 29478938
Productive cough 26.87 10.77 37 95528 31222 29447740
Accident 26.71 10.77 45 95520 3643 29475319
Parkinsonism 26.67 10.77 67 95498 7211 29471751
Victim of chemical submission 26.66 10.77 9 95556 45 29478917
Dependence 26.65 10.77 24 95541 1011 29477951
Injection site pain 26.32 10.77 40 95525 32406 29446556
Sleep disorder 26.03 10.77 151 95414 24235 29454727
Nervousness 25.91 10.77 88 95477 11218 29467744
Muscle spasticity 25.80 10.77 52 95513 4831 29474131
Inadequate analgesia 25.67 10.77 37 95528 2617 29476345
Stiff person syndrome 25.56 10.77 10 95555 81 29478881
Anaphylactic reaction 25.39 10.77 31 95534 27542 29451420
Blood creatinine increased 25.27 10.77 166 95399 84936 29394026
Oral discharge 25.26 10.77 11 95554 120 29478842
Electroencephalogram abnormal 24.73 10.77 34 95531 2301 29476661
Urticaria 24.66 10.77 92 95473 54568 29424394
Blepharospasm 24.32 10.77 23 95542 1032 29477930
Blood pressure systolic increased 24.30 10.77 12 95553 16833 29462129
Homicidal ideation 24.14 10.77 35 95530 2489 29476473
Inappropriate schedule of product administration 24.11 10.77 69 95496 44403 29434559
Catatonia 24.11 10.77 48 95517 4420 29474542
Victim of crime 24.03 10.77 15 95550 358 29478604
Spleen congestion 23.97 10.77 14 95551 295 29478667
Treatment noncompliance 23.93 10.77 147 95418 24080 29454882
Abnormal dreams 23.60 10.77 62 95503 6858 29472104
Herpes zoster 23.47 10.77 38 95527 30014 29448948
Osteonecrosis of jaw 23.46 10.77 12 95553 16498 29462464
Pruritus genital 23.45 10.77 17 95548 523 29478439
Sexual abuse 23.42 10.77 11 95554 145 29478817
Suicide threat 23.29 10.77 7 95558 22 29478940
Necrotising colitis 23.28 10.77 22 95543 986 29477976
Dyskinesia 23.25 10.77 127 95438 19934 29459028
Thrombosis 23.18 10.77 67 95498 42978 29435984
Depressed mood 23.18 10.77 110 95455 16338 29462624
Hospitalisation 23.04 10.77 74 95491 45914 29433048
Basilar migraine 22.96 10.77 6 95559 9 29478953
Hypomagnesaemia 22.94 10.77 14 95551 17454 29461508
Fatty liver alcoholic 22.89 10.77 9 95556 74 29478888
Cytokine release syndrome 22.79 10.77 7 95558 13112 29465850
Pulmonary fibrosis 22.63 10.77 11 95554 15571 29463391
Needle track marks 22.58 10.77 6 95559 10 29478952
Crystalluria 22.56 10.77 15 95550 400 29478562
Stereotypy 22.55 10.77 18 95547 641 29478321
Persecutory delusion 22.42 10.77 31 95534 2110 29476852
Impaired self-care 22.14 10.77 21 95544 946 29478016
Osmolar gap abnormal 21.99 10.77 7 95558 28 29478934
Neutrophil count increased 21.81 10.77 100 95465 14642 29464320
Patient restraint 21.71 10.77 9 95556 86 29478876
Reaction to excipient 21.64 10.77 15 95550 429 29478533
Diet refusal 21.52 10.77 13 95552 292 29478670
Electrolyte imbalance 21.51 10.77 5 95560 11269 29467693
Hypocalcaemia 21.49 10.77 21 95544 20644 29458318
Pancreatitis 21.43 10.77 50 95515 34464 29444498
Pain in extremity 21.32 10.77 241 95324 110192 29368770
Libido disorder 21.23 10.77 12 95553 237 29478725
Arthropathy 21.18 10.77 23 95542 21531 29457431
Fluid retention 21.15 10.77 27 95538 23533 29455429
Arthritis 21.12 10.77 30 95535 24989 29453973
Asthma 21.05 10.77 49 95516 33800 29445162
Treatment failure 21.00 10.77 56 95509 36883 29442079
Penis injury 20.79 10.77 12 95553 247 29478715
Full blood count decreased 20.74 10.77 13 95552 15979 29462983
Rash pruritic 20.74 10.77 25 95540 22338 29456624
Tubulointerstitial nephritis 20.69 10.77 16 95549 17627 29461335
Reflexes abnormal 20.36 10.77 13 95552 323 29478639
Melaena 20.31 10.77 44 95521 31132 29447830
Pulmonary contusion 20.26 10.77 7 95558 38 29478924
Basal cell carcinoma 20.26 10.77 15 95550 16895 29462067
Coronary artery disease 20.18 10.77 74 95491 44116 29434846
Somnambulism 20.08 10.77 34 95531 2764 29476198
Cardiomegaly 20.05 10.77 93 95472 13683 29465279
Schizoaffective disorder 19.99 10.77 21 95544 1071 29477891
Alcoholism 19.98 10.77 33 95532 2628 29476334
Rectal haemorrhage 19.93 10.77 52 95513 34497 29444465
Personal relationship issue 19.89 10.77 12 95553 269 29478693
Transplant rejection 19.89 10.77 3 95562 9209 29469753
Hepatocellular injury 19.80 10.77 127 95438 21116 29457846
Full blood count abnormal 19.76 10.77 12 95553 15001 29463961
Road traffic accident 19.74 10.77 101 95464 15460 29463502
Claustrophobia 19.70 10.77 11 95554 212 29478750
Subacute endocarditis 19.68 10.77 7 95558 42 29478920
Portal tract inflammation 19.62 10.77 8 95557 73 29478889
Cytopenia 19.56 10.77 4 95561 9855 29469107
Illusion 19.51 10.77 17 95548 685 29478277
Metastases to liver 19.42 10.77 7 95558 11849 29467113
Hypercapnic coma 19.40 10.77 10 95555 163 29478799
Hallucinations, mixed 19.40 10.77 31 95534 2402 29476560
White blood cell count decreased 19.37 10.77 174 95391 83188 29395774
Persistent depressive disorder 19.31 10.77 12 95553 284 29478678
Neoplasm progression 19.26 10.77 19 95546 18593 29460369
Opisthotonus 19.05 10.77 14 95551 440 29478522
Blood creatine phosphokinase increased 19.00 10.77 208 95357 40436 29438526
Affect lability 18.90 10.77 37 95528 3365 29475597
Bacteraemia 18.89 10.77 15 95550 16308 29462654
Cataract 18.72 10.77 27 95538 22351 29456611
Medication error 18.67 10.77 125 95440 21086 29457876
Accidental poisoning 18.58 10.77 15 95550 543 29478419
Wheezing 18.44 10.77 51 95514 33189 29445773
Angina pectoris 18.40 10.77 39 95526 27811 29451151
Personality change 18.38 10.77 44 95521 4594 29474368
Hallucination 18.30 10.77 223 95342 44489 29434473
Leukopenia 18.30 10.77 104 95461 55099 29423863
Congestive hepatopathy 18.22 10.77 25 95540 1689 29477273
Respiratory acidosis 18.18 10.77 42 95523 4286 29474676
Abdominal pain upper 18.08 10.77 119 95446 60874 29418088
Movement disorder 17.87 10.77 73 95492 10164 29468798
Disinhibition 17.82 10.77 31 95534 2576 29476386
Cellulitis 17.66 10.77 82 95483 45758 29433204
Sensory integrative dysfunction 17.61 10.77 6 95559 31 29478931
Clumsiness 17.59 10.77 23 95542 1483 29477479
Penile haemorrhage 17.54 10.77 15 95550 589 29478373
Skin ulcer 17.54 10.77 21 95544 18819 29460143
Femoral nerve palsy 17.46 10.77 6 95559 32 29478930
Affective disorder 17.37 10.77 34 95531 3092 29475870
Hostility 17.30 10.77 17 95548 800 29478162
Multiple organ dysfunction syndrome 17.30 10.77 126 95439 62990 29415972
Rebound psychosis 17.23 10.77 9 95556 151 29478811
Apnoea 17.19 10.77 51 95514 6051 29472911
Priapism 17.17 10.77 42 95523 4446 29474516
Obsessive thoughts 17.16 10.77 15 95550 607 29478355
Emotional disorder of childhood 17.16 10.77 6 95559 34 29478928
Mobility decreased 17.11 10.77 36 95529 25744 29453218
Hyperbilirubinaemia 16.94 10.77 14 95551 14920 29464042
Therapeutic response decreased 16.83 10.77 34 95531 24677 29454285
Inappropriate antidiuretic hormone secretion 16.80 10.77 75 95490 10857 29468105
Diabetes mellitus 16.71 10.77 69 95496 39762 29439200
Paradoxical drug reaction 16.70 10.77 31 95534 2710 29476252
COVID-19 pneumonia 16.69 10.77 5 95560 9517 29469445
Stupor 16.67 10.77 31 95534 2713 29476249
Lymphadenopathy 16.61 10.77 35 95530 25014 29453948
Abdominal distension 16.60 10.77 84 95481 45827 29433135
Prostatic specific antigen increased 16.59 10.77 10 95555 12554 29466408
Drug tolerance 16.57 10.77 27 95538 2126 29476836
Hangover 16.49 10.77 18 95547 959 29478003
Antipsychotic drug level decreased 16.42 10.77 17 95548 852 29478110
Myofascial pain syndrome 16.36 10.77 11 95554 299 29478663
Nephrolithiasis 16.30 10.77 36 95529 25298 29453664
Blunted affect 16.30 10.77 11 95554 301 29478661
White blood cell count increased 16.18 10.77 189 95376 37327 29441635
Drug level increased 16.11 10.77 110 95455 18677 29460285
Tearfulness 16.11 10.77 23 95542 1613 29477349
Mania 16.10 10.77 63 95502 8600 29470362
Psoriasis 16.04 10.77 52 95513 32175 29446787
Deep vein thrombosis 16.02 10.77 114 95451 57285 29421677
Hyperglycaemia 15.93 10.77 57 95508 34230 29444732
Haemophagocytic lymphohistiocytosis 15.89 10.77 7 95558 10497 29468465
Hepatic function abnormal 15.86 10.77 69 95496 39190 29439772
Sluggishness 15.83 10.77 32 95533 2979 29475983
Inflammation 15.71 10.77 31 95534 22697 29456265
Bone pain 15.70 10.77 22 95543 18430 29460532
Septic shock 15.69 10.77 128 95437 62432 29416530
Slow speech 15.68 10.77 17 95548 899 29478063
Neuromuscular toxicity 15.51 10.77 6 95559 47 29478915
Drug withdrawal maintenance therapy 15.48 10.77 7 95558 84 29478878
Abdominal discomfort 15.47 10.77 91 95474 47812 29431150
Bezoar 15.44 10.77 16 95549 803 29478159
Incoherent 15.34 10.77 38 95527 4054 29474908
Contraindicated product administered 15.32 10.77 22 95543 18244 29460718
Bradycardia neonatal 15.32 10.77 17 95548 923 29478039
Graft versus host disease 15.24 10.77 6 95559 9622 29469340
Hyperkalaemia 15.22 10.77 126 95439 61266 29417696
Myocardial depression 15.19 10.77 6 95559 50 29478912
Diverticulitis 15.17 10.77 21 95544 17683 29461279
Breech presentation 15.17 10.77 8 95557 137 29478825
Blood alcohol increased 15.11 10.77 15 95550 715 29478247
Sciatic nerve neuropathy 15.09 10.77 6 95559 51 29478911
Aspartate aminotransferase increased 15.07 10.77 122 95443 59603 29419359
Upper gastrointestinal haemorrhage 15.06 10.77 30 95535 21884 29457078
Incorrect route of product administration 15.05 10.77 72 95493 10729 29468233
Apathy 15.00 10.77 49 95516 6122 29472840
Squamous cell carcinoma of skin 14.87 10.77 6 95559 9480 29469482
Haemorrhage intracranial 14.87 10.77 15 95550 14527 29464435
Chemical poisoning 14.85 10.77 7 95558 93 29478869
Post-traumatic stress disorder 14.80 10.77 22 95543 1600 29477362
Congenital pulmonary valve atresia 14.79 10.77 6 95559 54 29478908
Prescription form tampering 14.73 10.77 12 95553 440 29478522
Ex-drug abuser 14.72 10.77 8 95557 146 29478816
Pathogen resistance 14.71 10.77 4 95561 8112 29470850
Eosinophilic myocarditis 14.66 10.77 12 95553 443 29478519
Muscular weakness 14.64 10.77 129 95436 61923 29417039
Muscle twitching 14.62 10.77 58 95507 7968 29470994
Forearm fracture 14.60 10.77 6 95559 56 29478906
Coma acidotic 14.58 10.77 4 95561 8 29478954
Hepatotoxicity 14.52 10.77 22 95543 17845 29461117
Staring 14.49 10.77 20 95545 1359 29477603
Drug tolerance increased 14.48 10.77 12 95553 451 29478511
Colitis ulcerative 14.45 10.77 12 95553 12757 29466205
Liver disorder 14.35 10.77 44 95521 27705 29451257
Metastases to bone 14.35 10.77 7 95558 9891 29469071
Hyponatraemic coma 14.35 10.77 5 95560 28 29478934
Blood ketone body increased 14.30 10.77 11 95554 371 29478591
Mood altered 14.29 10.77 58 95507 8053 29470909
Dry skin 14.28 10.77 34 95531 23273 29455689
Flushing 14.28 10.77 47 95518 28945 29450017
Lymphoma 14.18 10.77 7 95558 9821 29469141
Learning disorder 14.16 10.77 17 95548 1005 29477957
Crime 14.15 10.77 6 95559 61 29478901
Poverty of speech 14.12 10.77 9 95556 223 29478739
Tuberculosis 14.11 10.77 3 95562 7193 29471769
Irregular breathing 14.10 10.77 7 95558 105 29478857
Pneumoconiosis 14.08 10.77 9 95556 224 29478738
Skin lesion 14.02 10.77 24 95541 18548 29460414
Syncope 14.01 10.77 182 95383 81189 29397773
Hyperthermia 13.97 10.77 64 95501 9366 29469596
Alcohol intolerance 13.97 10.77 11 95554 384 29478578
Mucosal erosion 13.95 10.77 14 95551 676 29478286
Ejaculation delayed 13.94 10.77 9 95556 228 29478734
Social anxiety disorder 13.87 10.77 9 95556 230 29478732
Depressive symptom 13.86 10.77 22 95543 1695 29477267
Sexually inappropriate behaviour 13.80 10.77 11 95554 391 29478571
Haematocrit decreased 13.64 10.77 48 95517 28974 29449988
Aura 13.61 10.77 10 95555 314 29478648
Herbal interaction 13.61 10.77 10 95555 314 29478648
Terminal insomnia 13.56 10.77 11 95554 401 29478561
Oedema 13.56 10.77 76 95489 40407 29438555
Anticonvulsant drug level increased 13.54 10.77 20 95545 1446 29477516
Rhinorrhoea 13.50 10.77 31 95534 21488 29457474
Vascular stenosis 13.47 10.77 8 95557 174 29478788
Colon cancer 13.45 10.77 4 95561 7651 29471311
Electrocardiogram J wave 13.45 10.77 4 95561 12 29478950
Physical abuse 13.45 10.77 4 95561 12 29478950
Selective mutism 13.42 10.77 6 95559 70 29478892
Gait disturbance 13.42 10.77 321 95244 73028 29405934
Hypersensitivity 13.37 10.77 108 95457 52795 29426167
Physical assault 13.36 10.77 17 95548 1067 29477895
Haemorrhage 13.32 10.77 88 95477 44984 29433978
Hanging 13.32 10.77 7 95558 119 29478843
Neutropenic sepsis 13.29 10.77 11 95554 11716 29467246
Laboratory test abnormal 13.28 10.77 24 95541 18161 29460801
Analgesic drug level above therapeutic 13.25 10.77 9 95556 249 29478713
Suspected suicide attempt 13.22 10.77 7 95558 121 29478841
Myelosuppression 13.21 10.77 12 95553 12215 29466747
Protrusion tongue 13.15 10.77 8 95557 182 29478780
Condition aggravated 13.13 10.77 366 95199 145929 29333033
Respiratory rate decreased 13.13 10.77 23 95542 1922 29477040
Therapeutic product effect incomplete 13.05 10.77 74 95491 39231 29439731
Polyneuropathy 13.05 10.77 12 95553 12140 29466822
Cardiac disorder 13.00 10.77 69 95496 37194 29441768
Delirium tremens 12.96 10.77 12 95553 524 29478438
Accident at work 12.93 10.77 13 95552 629 29478333
Drug hypersensitivity 12.91 10.77 150 95415 68256 29410706
Erectile dysfunction 12.89 10.77 101 95464 17908 29461054
Antasthmatic drug level 12.83 10.77 5 95560 40 29478922
Analgesic drug level 12.83 10.77 5 95560 40 29478922
Blood bilirubin increased 12.83 10.77 61 95504 33832 29445130
Dissociation 12.81 10.77 17 95548 1112 29477850
Family stress 12.72 10.77 7 95558 131 29478831
Sciatic nerve injury 12.71 10.77 6 95559 80 29478882
Frequent bowel movements 12.70 10.77 7 95558 9232 29469730
Neoplasm malignant 12.66 10.77 22 95543 16903 29462059
Substance use disorder 12.64 10.77 9 95556 269 29478693
Febrile bone marrow aplasia 12.63 10.77 4 95561 7347 29471615
Product counterfeit 12.58 10.77 7 95558 134 29478828
Hypoglycaemia 12.54 10.77 98 95467 48248 29430714
Impaired driving ability 12.53 10.77 25 95540 2306 29476656
Back pain 12.50 10.77 244 95321 102040 29376922
Swelling 12.50 10.77 65 95500 35218 29443744
Adverse drug reaction 12.49 10.77 38 95527 23982 29454980
Wrong dose 12.46 10.77 11 95554 451 29478511
Myocarditis 12.45 10.77 69 95496 10887 29468075
Potentiating drug interaction 12.41 10.77 37 95528 4401 29474561
Death 12.40 10.77 1274 94291 340810 29138152
Squamous cell carcinoma 12.40 10.77 9 95556 10242 29468720
Necrotising enterocolitis neonatal 12.38 10.77 8 95557 203 29478759
Delusional disorder, unspecified type 12.36 10.77 13 95552 664 29478298
Patient uncooperative 12.29 10.77 10 95555 366 29478596
Communication disorder 12.27 10.77 25 95540 2340 29476622
Ileus paralytic 12.27 10.77 41 95524 5182 29473780
Speech disorder 12.24 10.77 123 95442 23393 29455569
Binge drinking 12.15 10.77 3 95562 3 29478959
Panic disorder 12.11 10.77 17 95548 1173 29477789
Oxygen saturation abnormal 12.09 10.77 17 95548 1175 29477787
Skull fractured base 11.84 10.77 7 95558 151 29478811
Xanthelasma 11.80 10.77 6 95559 95 29478867
Social avoidant behaviour 11.76 10.77 28 95537 2914 29476048
Blood pressure diastolic decreased 11.75 10.77 4 95561 7018 29471944
Alanine aminotransferase increased 11.73 10.77 160 95405 70784 29408178
Kidney transplant rejection 11.70 10.77 4 95561 7001 29471961
Blood glucose increased 11.66 10.77 128 95437 58856 29420106
Bradycardia 11.64 10.77 286 95279 65343 29413619
Antipsychotic drug level above therapeutic 11.61 10.77 16 95549 1085 29477877
Carbon monoxide poisoning 11.58 10.77 6 95559 99 29478863
Diffuse large B-cell lymphoma 11.55 10.77 3 95562 6273 29472689
Cerebrovascular stenosis 11.52 10.77 6 95559 100 29478862
Substance-induced psychotic disorder 11.50 10.77 18 95547 1370 29477592
Oral pain 11.48 10.77 8 95557 9299 29469663
Neutrophil count decreased 11.45 10.77 88 95477 43479 29435483
Hypertension 11.45 10.77 288 95277 116326 29362636
Stress at work 11.44 10.77 7 95558 161 29478801
Hepatitis cholestatic 11.41 10.77 4 95561 6889 29472073
Loss of personal independence in daily activities 11.35 10.77 43 95522 25397 29453565
Thrombotic microangiopathy 11.34 10.77 7 95558 8674 29470288
Disturbance in social behaviour 11.32 10.77 20 95545 1682 29477280
Cerebellar syndrome 11.31 10.77 22 95543 1992 29476970
Erythrosis 11.29 10.77 5 95560 57 29478905
Faeces discoloured 11.28 10.77 16 95549 13335 29465627
Myositis 11.22 10.77 10 95555 10273 29468689
Refusal of treatment by patient 11.17 10.77 37 95528 4657 29474305
Myalgia 11.16 10.77 170 95395 73849 29405113
Hepatic enzyme increased 11.02 10.77 64 95501 33735 29445227
Osteomyelitis 11.02 10.77 17 95548 13692 29465270
Blood urine 10.99 10.77 10 95555 427 29478535
Haemoptysis 10.98 10.77 56 95509 30494 29448468
Fungal infection 10.97 10.77 17 95548 13668 29465294
Coma scale 10.94 10.77 3 95562 6 29478956
Oral tuberculosis 10.94 10.77 3 95562 6 29478956
Respiratory failure 10.89 10.77 235 95330 96896 29382066
Transfusion 10.83 10.77 5 95560 7293 29471669
Cerebral infarction 10.82 10.77 42 95523 24633 29454329

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug abuse 5768.34 10.03 4030 187988 128344 64178370
Toxicity to various agents 5124.41 10.03 5827 186191 357686 63949028
Completed suicide 2176.06 10.03 2992 189026 221422 64085292
Intentional overdose 1554.20 10.03 1612 190406 88332 64218382
Coma 1445.36 10.03 1532 190486 86083 64220631
Overdose 1426.09 10.03 2048 189970 157518 64149196
Respiratory arrest 1332.86 10.03 1169 190849 51816 64254898
Poisoning 1127.09 10.03 741 191277 21138 64285576
Drug dependence 1074.61 10.03 849 191169 32463 64274251
Suicide attempt 998.00 10.03 1142 190876 69865 64236849
Somnolence 922.71 10.03 1936 190082 201709 64105005
Intentional product misuse 769.90 10.03 1011 191007 71284 64235430
Cardiac arrest 682.51 10.03 1452 190566 152612 64154102
Poisoning deliberate 669.27 10.03 446 191572 13012 64293702
Respiratory depression 604.72 10.03 525 191493 22918 64283796
Drug withdrawal syndrome 602.11 10.03 595 191423 30696 64276018
Cardio-respiratory arrest 595.16 10.03 1058 190960 97335 64209379
Sopor 593.11 10.03 576 191442 29085 64277629
Intentional self-injury 575.10 10.03 561 191457 28483 64278231
Agitation 550.95 10.03 963 191055 87404 64219310
Miosis 545.21 10.03 391 191627 12875 64293839
Aggression 498.91 10.03 651 191367 45581 64261133
Substance abuse 483.98 10.03 317 191701 8975 64297739
Suicidal ideation 458.08 10.03 758 191260 65784 64240930
Accidental overdose 436.52 10.03 519 191499 33038 64273676
Depressed level of consciousness 426.19 10.03 823 191195 80613 64226101
Neuroleptic malignant syndrome 376.39 10.03 417 191601 24579 64282135
Bradypnoea 352.08 10.03 209 191809 4950 64301764
Drug interaction 323.86 10.03 2012 190006 360071 63946643
Psychotic disorder 320.00 10.03 452 191566 34126 64272588
Febrile neutropenia 292.39 10.03 97 191921 187560 64119154
Withdrawal syndrome 290.23 10.03 354 191664 23138 64283576
Diarrhoea 287.60 10.03 1144 190874 721560 63585154
Joint swelling 276.86 10.03 148 191870 215234 64091480
Rheumatoid arthritis 275.82 10.03 74 191944 164220 64142494
Infusion related reaction 270.64 10.03 77 191941 164390 64142324
Schizophrenia 267.75 10.03 240 191778 10928 64295786
Pneumonia aspiration 258.95 10.03 556 191462 58715 64247999
Asphyxia 252.24 10.03 217 191801 9349 64297365
Synovitis 244.78 10.03 12 192006 99078 64207636
Drug abuser 235.91 10.03 170 191848 5638 64301076
Bradyphrenia 235.17 10.03 207 191811 9199 64297515
Anaemia 228.47 10.03 492 191526 378188 63928526
Restlessness 227.80 10.03 418 191600 39367 64267347
Drug intolerance 226.13 10.03 140 191878 187852 64118862
Serotonin syndrome 225.27 10.03 413 191605 38869 64267845
Disturbance in attention 222.00 10.03 421 191597 40653 64266061
Congenital nystagmus 221.09 10.03 52 191966 40 64306674
Arthralgia 220.54 10.03 634 191384 441626 63865088
Rash 217.40 10.03 673 191345 457876 63848838
Sedation 215.52 10.03 418 191600 41044 64265670
Mydriasis 192.81 10.03 233 191785 15079 64291635
Seizure 188.63 10.03 988 191030 165904 64140810
Peripheral swelling 184.86 10.03 210 191808 208943 64097771
Altered state of consciousness 182.41 10.03 370 191648 37532 64269182
Cough 181.77 10.03 393 191625 301755 64004959
Dyspnoea 179.45 10.03 1329 190689 717345 63589369
Off label use 178.34 10.03 1129 190889 631677 63675037
Dysarthria 177.35 10.03 481 191537 58925 64247789
Nasopharyngitis 175.32 10.03 195 191823 195878 64110836
Coma scale abnormal 174.48 10.03 161 191857 7613 64299101
Anxiety 173.81 10.03 1115 190903 201534 64105180
Tremor 169.88 10.03 881 191137 147349 64159365
Salivary hypersecretion 168.56 10.03 194 191824 11919 64294795
Contraindicated product administered 165.68 10.03 57 191961 107772 64198942
Accidental death 165.09 10.03 115 191903 3610 64303104
Arthropathy 164.55 10.03 77 191941 120890 64185824
Pemphigus 161.55 10.03 4 192014 60697 64246017
Fatigue 159.74 10.03 1444 190574 747286 63559428
Hypothermia 159.71 10.03 243 191775 19613 64287101
Exposure via ingestion 158.09 10.03 125 191893 4777 64301937
Drug withdrawal convulsions 157.85 10.03 91 191927 2037 64304677
Acute kidney injury 152.77 10.03 753 191265 448487 63858227
Panic attack 152.63 10.03 245 191773 20708 64286006
Drug ineffective 151.27 10.03 1688 190330 838559 63468155
Tachycardia 151.12 10.03 859 191159 148720 64157994
Abnormal behaviour 148.65 10.03 317 191701 33305 64273409
Loss of consciousness 148.56 10.03 850 191168 147515 64159199
Thrombocytopenia 148.32 10.03 275 191743 223526 64083188
Treatment failure 147.48 10.03 82 191936 116734 64189980
Visceral congestion 147.35 10.03 64 191954 758 64305956
Housebound 145.24 10.03 54 191964 411 64306303
Hand deformity 144.80 10.03 11 192007 62760 64243954
Extrapyramidal disorder 144.32 10.03 230 191788 19322 64287392
Muscle rigidity 142.18 10.03 215 191803 17258 64289456
Death 139.85 10.03 2113 189905 480592 63826122
Nightmare 138.82 10.03 235 191783 20758 64285956
Disorientation 137.59 10.03 422 191596 55406 64251308
Delirium 137.36 10.03 486 191532 68708 64238006
Status epilepticus 137.33 10.03 238 191780 21425 64285289
Systemic lupus erythematosus 135.90 10.03 32 191986 77580 64229134
Malignant neoplasm progression 135.74 10.03 84 191934 112787 64193927
Interstitial lung disease 133.24 10.03 62 191956 97670 64209044
Pericarditis 130.93 10.03 16 192002 62500 64244214
Disease progression 127.60 10.03 140 191878 141540 64165174
Drug use disorder 127.45 10.03 121 191897 5933 64300781
Therapeutic product effect decreased 126.49 10.03 95 191923 115256 64191458
Depression 125.62 10.03 955 191063 182336 64124378
Logorrhoea 125.55 10.03 101 191917 3958 64302756
Infection 125.30 10.03 224 191794 184656 64122058
Stomatitis 124.45 10.03 87 191931 109518 64197196
Dystonia 121.87 10.03 209 191809 18656 64288058
Hypersensitivity 120.98 10.03 252 191766 196200 64110514
Mood swings 120.12 10.03 199 191819 17269 64289445
General physical health deterioration 116.23 10.03 274 191744 204151 64102563
Nystagmus 115.82 10.03 139 191879 8929 64297785
Irritability 115.18 10.03 303 191715 36443 64270271
Alopecia 112.95 10.03 200 191818 165490 64141224
Swelling 111.39 10.03 191 191827 160027 64146687
Pulmonary congestion 110.03 10.03 229 191789 23651 64283063
Sinusitis 109.89 10.03 165 191853 145763 64160951
Abdominal discomfort 109.64 10.03 237 191781 182085 64124629
Developmental delay 109.39 10.03 56 191962 981 64305733
Glossodynia 108.77 10.03 29 191989 64667 64242047
Pancytopenia 107.95 10.03 162 191856 143147 64163567
Dissociation 106.28 10.03 81 191937 2930 64303784
Pyrexia 105.52 10.03 1109 190909 557535 63749179
Emotional disorder 105.24 10.03 157 191861 12450 64294264
Haemoglobin decreased 104.96 10.03 269 191749 194794 64111920
Drug screen positive 104.73 10.03 106 191912 5623 64301091
Psychomotor hyperactivity 103.92 10.03 168 191850 14283 64292431
Atrial fibrillation 103.20 10.03 222 191796 170867 64135847
Hyperhidrosis 103.11 10.03 681 191337 124239 64182475
Confusional state 100.54 10.03 1204 190814 259940 64046774
Delusion 100.24 10.03 187 191831 17827 64288887
Dyskinesia 97.29 10.03 298 191720 39090 64267624
Alcohol poisoning 97.20 10.03 89 191929 4166 64302548
Cardiac failure congestive 97.01 10.03 149 191869 130431 64176283
Sepsis 96.64 10.03 356 191662 229985 64076729
Mucosal inflammation 96.26 10.03 33 191985 62551 64244163
Aspiration 94.86 10.03 176 191842 16709 64290005
Strabismus congenital 94.49 10.03 23 191995 24 64306690
Neutropenia 94.33 10.03 380 191638 239244 64067470
Agoraphobia 92.90 10.03 41 191977 506 64306208
Dyspnoea exertional 92.69 10.03 52 191966 73678 64233036
Anger 90.85 10.03 166 191852 15575 64291139
Therapeutic product effect incomplete 90.16 10.03 105 191913 103377 64203337
Akathisia 89.94 10.03 139 191879 11371 64295343
COVID-19 89.28 10.03 41 191977 65099 64241615
Wound 89.08 10.03 59 191959 76418 64230296
Pneumonia 88.18 10.03 1156 190862 558420 63748294
Platelet count decreased 86.62 10.03 236 191782 167475 64139239
Derealisation 85.24 10.03 54 191964 1441 64305273
Electrocardiogram QT prolonged 83.30 10.03 461 191557 78987 64227727
Pruritus 83.29 10.03 566 191452 311834 63994880
Hypotonia 82.89 10.03 132 191886 11080 64295634
Hypomania 82.81 10.03 93 191925 5561 64301153
Hallucinations, mixed 82.64 10.03 96 191922 5956 64300758
Helicobacter infection 82.37 10.03 9 192009 38353 64268361
Gastric pH decreased 81.34 10.03 41 191977 694 64306020
Suicidal behaviour 81.25 10.03 68 191950 2819 64303895
Gastrointestinal haemorrhage 80.34 10.03 171 191847 132141 64174573
Nausea 79.42 10.03 1760 190258 784040 63522674
Self-injurious ideation 79.20 10.03 70 191948 3127 64303587
Cytomegalovirus infection 79.18 10.03 9 192009 37190 64269524
Injection site pain 79.08 10.03 131 191887 111277 64195437
Mania 78.35 10.03 159 191859 16127 64290587
Alcohol abuse 78.34 10.03 84 191934 4768 64301946
Depersonalisation/derealisation disorder 78.28 10.03 53 191965 1587 64305127
Generalised tonic-clonic seizure 77.41 10.03 278 191740 39579 64267135
Parkinsonism 77.24 10.03 147 191871 14226 64292488
Discomfort 77.21 10.03 76 191942 80802 64225912
Pain 77.07 10.03 1172 190846 552339 63754375
Abdominal pain 76.93 10.03 579 191439 311796 63994918
Hallucination, auditory 76.36 10.03 161 191857 16778 64289936
Feeling of despair 75.42 10.03 62 191956 2506 64304208
Brain oedema 75.36 10.03 188 191830 21887 64284827
Arthritis 75.24 10.03 83 191935 83731 64222983
Hallucination 74.08 10.03 419 191599 72369 64234345
Bradykinesia 73.25 10.03 94 191924 6466 64300248
Psychomotor skills impaired 71.86 10.03 72 191946 3773 64302941
Unresponsive to stimuli 71.75 10.03 319 191699 50074 64256640
Respiratory acidosis 71.45 10.03 115 191903 9740 64296974
Pleural effusion 70.80 10.03 171 191847 126388 64180326
Urinary retention 70.46 10.03 312 191706 48889 64257825
C-reactive protein abnormal 70.20 10.03 4 192014 29043 64277671
Erythema 69.66 10.03 303 191715 186767 64119947
Sudden death 69.50 10.03 172 191846 19924 64286790
Product dose omission issue 68.00 10.03 323 191695 194424 64112290
Cogwheel rigidity 67.77 10.03 61 191957 2792 64303922
Folliculitis 67.34 10.03 6 192012 30071 64276643
Drooling 67.06 10.03 81 191937 5238 64301476
Urticaria 66.92 10.03 220 191798 147097 64159617
Snoring 66.85 10.03 76 191942 4606 64302108
Catatonia 66.64 10.03 97 191921 7523 64299191
Speech disorder 66.24 10.03 303 191715 48138 64258576
Ataxia 66.06 10.03 179 191839 21905 64284809
Impaired healing 66.02 10.03 50 191968 60423 64246291
Stiff person syndrome 65.95 10.03 26 191992 236 64306478
Bone marrow failure 64.45 10.03 31 191987 47921 64258793
Paranoia 64.16 10.03 147 191871 16205 64290509
Herpes zoster 64.10 10.03 85 191933 79102 64227612
Rhabdomyolysis 62.80 10.03 478 191540 91248 64215466
Sleep disorder due to general medical condition, insomnia type 62.33 10.03 4 192014 26266 64280448
Tearfulness 61.93 10.03 73 191945 4600 64302114
Pain in extremity 61.49 10.03 591 191427 302494 64004220
Dependence 61.15 10.03 51 191967 2104 64304610
Memory impairment 60.63 10.03 450 191568 85232 64221482
Blood pressure systolic increased 60.55 10.03 36 191982 49417 64257297
Blood pressure fluctuation 60.43 10.03 40 191978 51831 64254883
Gastrointestinal disorder 58.68 10.03 111 191907 89598 64217116
Pulmonary oedema 58.42 10.03 418 191600 78256 64228458
Antipsychotic drug level increased 58.23 10.03 74 191944 5041 64301673
Psychotic symptom 57.38 10.03 49 191969 2089 64304625
Hepatic enzyme increased 56.33 10.03 198 191820 129745 64176969
Hypervolaemia 55.81 10.03 22 191996 38263 64268451
Duodenal ulcer perforation 55.46 10.03 17 192001 34608 64272106
Inflammation 55.02 10.03 68 191950 65232 64241482
Ascites 54.98 10.03 62 191956 61939 64244775
Blood creatine phosphokinase increased 54.98 10.03 330 191688 58228 64248486
Arteriosclerosis coronary artery 54.85 10.03 134 191884 15395 64291319
Prescription drug used without a prescription 54.80 10.03 52 191966 2548 64304166
Toxicologic test abnormal 54.71 10.03 38 191980 1187 64305527
Thinking abnormal 54.62 10.03 112 191906 11444 64295270
Tension 54.26 10.03 62 191956 3778 64302936
Optic nerve hypoplasia 53.67 10.03 12 192006 5 64306709
Fluid retention 53.52 10.03 59 191959 59547 64247167
Pneumocystis jirovecii pneumonia 53.37 10.03 9 192009 27625 64279089
Strabismus 53.36 10.03 47 191971 2090 64304624
Asthenia 53.29 10.03 925 191093 427119 63879595
Depressed mood 52.75 10.03 252 191766 40760 64265954
Blood pressure increased 52.46 10.03 300 191718 172252 64134462
Oropharyngeal pain 52.16 10.03 117 191901 88750 64217964
Cardiac failure 51.99 10.03 210 191808 132163 64174551
Colitis 51.67 10.03 59 191959 58615 64248099
Oedema peripheral 51.65 10.03 390 191628 209927 64096787
Product use in unapproved indication 51.61 10.03 311 191707 176307 64130407
Neoplasm progression 51.32 10.03 29 191989 40935 64265779
Hypoxic-ischaemic encephalopathy 51.22 10.03 83 191935 7069 64299645
Accidental poisoning 51.09 10.03 39 191979 1414 64305300
Sinus tachycardia 50.62 10.03 210 191808 31978 64274736
Alcohol interaction 50.62 10.03 64 191954 4337 64302377
Productive cough 50.17 10.03 88 191930 73115 64233599
Epilepsy 49.81 10.03 215 191803 33316 64273398
Feeling of body temperature change 49.13 10.03 66 191952 4748 64301966
Inappropriate schedule of product administration 49.03 10.03 128 191890 92158 64214556
Drug hypersensitivity 48.94 10.03 462 191556 237353 64069361
Self-medication 48.83 10.03 61 191957 4084 64302630
Injection site erythema 48.63 10.03 85 191933 70715 64235999
Epistaxis 48.49 10.03 141 191877 97990 64208724
Insomnia 48.43 10.03 843 191175 196993 64109721
Behaviour disorder 48.36 10.03 63 191955 4399 64302315
Muscle injury 48.09 10.03 10 192008 26427 64280287
Mental disorder 47.61 10.03 180 191838 26265 64280449
H1N1 influenza 47.15 10.03 45 191973 2221 64304493
Electroencephalogram abnormal 46.62 10.03 67 191951 5136 64301578
Dehydration 46.37 10.03 417 191601 216346 64090368
Haematochezia 46.21 10.03 79 191939 66294 64240420
Hypertonia 46.12 10.03 74 191944 6251 64300463
International normalised ratio increased 45.83 10.03 105 191913 79062 64227652
Drug diversion 45.56 10.03 33 191985 1103 64305611
Product use issue 45.46 10.03 265 191753 151450 64155264
Blood creatinine increased 45.18 10.03 229 191789 135553 64171161
Drowning 45.08 10.03 28 191990 721 64305993
Acute myeloid leukaemia 44.87 10.03 13 192005 27450 64279264
Renal impairment 44.76 10.03 228 191790 134789 64171925
Jaundice cholestatic 44.53 10.03 87 191931 8583 64298131
Brain injury 44.09 10.03 94 191924 9871 64296843
Renal failure 44.08 10.03 338 191680 181350 64125364
Pneumonitis 43.97 10.03 51 191967 50314 64256400
Psychotic behaviour 43.81 10.03 31 191987 998 64305716
Mental impairment 43.52 10.03 127 191891 16216 64290498
Wheezing 43.39 10.03 111 191907 80468 64226246
Physical assault 42.65 10.03 36 191982 1510 64305204
Lower respiratory tract infection 42.47 10.03 142 191876 94472 64212242
Weight decreased 42.44 10.03 597 191421 285142 64021572
Congenital visual acuity reduced 42.34 10.03 10 192008 8 64306706
Pulmonary fibrosis 42.20 10.03 18 192000 29860 64276854
Osteonecrosis of jaw 42.11 10.03 34 191984 39791 64266923
Hyperkalaemia 41.90 10.03 157 191861 100972 64205742
Myelodysplastic syndrome 41.62 10.03 15 192003 27564 64279150
Loss of personal independence in daily activities 41.22 10.03 97 191921 72357 64234357
Skin ulcer 41.19 10.03 42 191976 43932 64262782
Postmortem blood drug level abnormal 41.01 10.03 25 191993 622 64306092
Sleep disorder 40.77 10.03 311 191707 59398 64247316
Asthma 40.66 10.03 146 191872 95079 64211635
Myoglobin urine present 40.51 10.03 24 191994 566 64306148
Basal cell carcinoma 39.84 10.03 21 191997 30817 64275897
Incontinence 39.26 10.03 101 191917 11980 64294734
Injection site pruritus 39.12 10.03 33 191985 37793 64268921
Parosmia 39.04 10.03 58 191960 4582 64302132
Immobilisation prolonged 38.90 10.03 14 192004 96 64306618
Bezoar 38.89 10.03 40 191978 2163 64304551
Neuropathy peripheral 38.65 10.03 199 191819 117326 64189388
Spleen congestion 38.49 10.03 21 191997 421 64306293
Abnormal dreams 38.33 10.03 91 191927 10265 64296449
Potentiating drug interaction 38.18 10.03 77 191941 7775 64298939
Electrocardiogram J wave 37.91 10.03 12 192006 52 64306662
Stupor 37.85 10.03 66 191952 5969 64300745
Decreased appetite 37.53 10.03 600 191418 280689 64026025
Hyperprolactinaemia 37.38 10.03 53 191965 4012 64302702
Psychomotor retardation 37.26 10.03 60 191958 5083 64301631
Victim of chemical submission 36.96 10.03 18 192000 282 64306432
Drug level increased 36.88 10.03 200 191818 33996 64272718
Clostridium difficile infection 36.85 10.03 32 191986 36131 64270583
Drug withdrawal syndrome neonatal 36.80 10.03 17 192001 235 64306479
Inadequate analgesia 36.78 10.03 52 191966 3926 64302788
Drug detoxification 36.67 10.03 17 192001 237 64306477
Bronchitis 36.40 10.03 183 191835 108560 64198154
Intentional product use issue 36.37 10.03 153 191865 95211 64211503
Nasal congestion 36.28 10.03 77 191941 59581 64247133
Respiratory rate decreased 36.16 10.03 55 191963 4436 64302278
Abdominal pain upper 36.00 10.03 340 191678 174690 64132024
Chest discomfort 35.74 10.03 201 191817 115905 64190809
Hypoventilation 35.50 10.03 64 191954 5942 64300772
Psychogenic seizure 35.38 10.03 35 191983 1806 64304908
Pancreatic fibrosis 35.30 10.03 13 192005 96 64306618
Autonomic nervous system imbalance 35.27 10.03 52 191966 4080 64302634
Cyanosis 35.19 10.03 145 191873 22010 64284704
Transplant rejection 35.12 10.03 5 192013 17396 64289318
Hyperthermia 35.04 10.03 114 191904 15436 64291278
Vision blurred 34.93 10.03 417 191601 89899 64216815
Reversible airways obstruction 34.53 10.03 28 191990 1110 64305604
Victim of sexual abuse 34.51 10.03 19 191999 388 64306326
Amnesia 34.41 10.03 254 191764 48015 64258699
Rash pruritic 34.15 10.03 75 191943 57329 64249385
Menstrual disorder 34.14 10.03 46 191972 3319 64303395
Knee arthroplasty 33.98 10.03 19 191999 26980 64279734
Schizoaffective disorder 33.94 10.03 32 191986 1555 64305159
Ill-defined disorder 33.92 10.03 49 191969 44003 64262711
Injection site reaction 33.92 10.03 54 191964 46610 64260104
Palmar-plantar erythrodysaesthesia syndrome 33.87 10.03 22 191996 28797 64277917
Therapeutic response decreased 33.75 10.03 65 191953 52123 64254591
Victim of crime 33.66 10.03 19 191999 408 64306306
Patient uncooperative 33.63 10.03 21 191997 546 64306168
Alcoholism 33.59 10.03 46 191972 3371 64303343
White blood cell count decreased 33.58 10.03 304 191714 157533 64149181
Echolalia 33.53 10.03 18 192000 349 64306365
Chronic kidney disease 33.38 10.03 77 191941 57842 64248872
Hepatic steatosis 33.21 10.03 181 191837 30826 64275888
Multiple sclerosis relapse 33.15 10.03 223 191795 40912 64265802
Coordination abnormal 33.09 10.03 109 191909 14855 64291859
Metastases to liver 32.91 10.03 15 192003 23926 64282788
Plasma cell myeloma 32.85 10.03 54 191964 46021 64260693
Injection site swelling 32.84 10.03 45 191973 41308 64265406
Social avoidant behaviour 32.79 10.03 53 191965 4504 64302210
Melaena 32.66 10.03 69 191949 53479 64253235
Angioedema 32.64 10.03 86 191932 61735 64244979
Necrotising colitis 32.45 10.03 25 191993 919 64305795
Hypercapnic coma 32.41 10.03 18 192000 374 64306340
Vestibular disorder 32.36 10.03 37 191981 2256 64304458
Transfusion 32.33 10.03 7 192011 17987 64288727
Cytopenia 32.29 10.03 4 192014 15467 64291247
Muscle disorder 32.17 10.03 55 191963 4896 64301818
Microcephaly 32.07 10.03 14 192004 168 64306546
Influenza 31.94 10.03 186 191832 106345 64200369
Vital capacity decreased 31.73 10.03 26 191992 1046 64305668
Autonomic dysreflexia 31.54 10.03 18 192000 395 64306319
Encephalitis toxic 31.52 10.03 16 192002 275 64306439
Opiates positive 31.35 10.03 24 191994 874 64305840
Haemophagocytic lymphohistiocytosis 31.34 10.03 7 192011 17602 64289112
Hospitalisation 30.99 10.03 117 191901 75090 64231624
Condition aggravated 30.94 10.03 858 191160 371568 63935146
Sexual abuse 30.86 10.03 13 192005 142 64306572
Chills 30.69 10.03 261 191757 137003 64169711
Generalised anxiety disorder 30.65 10.03 33 191985 1882 64304832
Blood pressure diastolic decreased 30.61 10.03 14 192004 22287 64284427
Psoriasis 30.56 10.03 110 191908 71593 64235121
Cellulitis 30.56 10.03 159 191859 93498 64213216
Treatment noncompliance 30.54 10.03 228 191790 43254 64263460
Cataract 30.48 10.03 67 191951 51195 64255519
Rectal haemorrhage 30.40 10.03 89 191929 61728 64244986
Tumour lysis syndrome 30.32 10.03 10 192008 19430 64287284
Acute psychosis 30.28 10.03 46 191972 3706 64303008
Incoherent 30.18 10.03 66 191952 7052 64299662
Homicide 30.12 10.03 26 191992 1125 64305589
Poor quality sleep 30.08 10.03 124 191894 18827 64287887
Pupillary disorder 29.96 10.03 18 192000 436 64306278
Rhinorrhoea 29.74 10.03 86 191932 59883 64246831
Apnoea 29.70 10.03 83 191935 10339 64296375
Acute myocardial infarction 29.69 10.03 107 191911 69611 64237103
Persecutory delusion 29.43 10.03 48 191970 4110 64302604
Device expulsion 29.43 10.03 13 192005 21123 64285591
Pyramidal tract syndrome 29.28 10.03 19 191999 529 64306185
Chemical submission 29.05 10.03 14 192004 214 64306500
Mobility decreased 28.99 10.03 144 191874 85696 64221018
Euphoric mood 28.96 10.03 62 191956 6529 64300185
Pulmonary arterial hypertension 28.95 10.03 20 191998 25347 64281367
Oedema 28.92 10.03 158 191860 91777 64214937
Penis injury 28.91 10.03 12 192006 126 64306588
Multiple sclerosis 28.55 10.03 122 191896 18819 64287895
Persistent depressive disorder 28.53 10.03 24 191994 1002 64305712
Myocardial fibrosis 28.45 10.03 29 191989 1551 64305163
Alcohol use 28.43 10.03 50 191968 4552 64302162
PO2 increased 28.00 10.03 28 191990 1464 64305250
Headache 27.94 10.03 1290 190728 528177 63778537
Prostate cancer 27.84 10.03 12 192006 19783 64286931
Therapeutic product ineffective 27.67 10.03 28 191990 1485 64305229
Haematuria 27.65 10.03 90 191928 60381 64246333
Blood pH decreased 27.42 10.03 48 191970 4354 64302360
Renal ischaemia 27.40 10.03 24 191994 1059 64305655
Irritable bowel syndrome 27.39 10.03 43 191975 37326 64269388
Urinary incontinence 27.36 10.03 193 191825 35958 64270756
Bacteraemia 27.19 10.03 24 191994 26887 64279827
PCO2 increased 27.16 10.03 29 191989 1638 64305076
Hyperglycaemia 27.01 10.03 92 191926 60876 64245838
Somnambulism 26.91 10.03 52 191966 5089 64301625
Feeling jittery 26.76 10.03 81 191937 10554 64296160
C-reactive protein increased 26.73 10.03 169 191849 94740 64211974
Leukopenia 26.63 10.03 184 191834 101058 64205656
Anterograde amnesia 26.60 10.03 19 191999 621 64306093
Sputum discoloured 26.46 10.03 10 192008 17846 64288868
Disinhibition 26.41 10.03 33 191985 2210 64304504
Calcium deficiency 26.37 10.03 20 191998 718 64305996
Neutrophil count decreased 26.35 10.03 129 191889 77067 64229647
Bladder dilatation 26.31 10.03 30 191988 1824 64304890
Cerebrovascular accident 26.30 10.03 272 191746 137311 64169403
Portal tract inflammation 26.13 10.03 11 192007 120 64306594
Antipsychotic drug level decreased 26.08 10.03 22 191996 922 64305792
Hypokinesia 25.88 10.03 108 191910 16488 64290226
Postmortem blood drug level increased 25.83 10.03 20 191998 741 64305973
Myoclonus 25.81 10.03 145 191873 24973 64281741
Red blood cell sedimentation rate increased 25.81 10.03 33 191985 31202 64275512
Mutism 25.68 10.03 31 191987 2003 64304711
Fatty liver alcoholic 25.62 10.03 9 192009 57 64306657
Injection site bruising 25.58 10.03 43 191975 36330 64270384
Hip arthroplasty 25.50 10.03 16 192002 21335 64285379
Fungal infection 25.50 10.03 39 191979 34212 64272502
Panic disorder 25.43 10.03 36 191982 2721 64303993
Cortisol increased 25.32 10.03 16 192002 425 64306289
Colitis ulcerative 25.18 10.03 19 191999 23009 64283705
Impaired reasoning 25.15 10.03 10 192008 93 64306621
Illusion 25.03 10.03 27 191991 1543 64305171
Apathy 25.00 10.03 82 191936 11150 64295564
Road traffic accident 24.97 10.03 167 191851 30578 64276136
COVID-19 pneumonia 24.86 10.03 9 192009 16495 64290219
Restless legs syndrome 24.85 10.03 109 191909 17007 64289707
Localised infection 24.78 10.03 32 191986 30129 64276585
Injection site warmth 24.67 10.03 5 192013 13457 64293257
Bronchopulmonary aspergillosis 24.65 10.03 13 192005 19072 64287642
Psoriatic arthropathy 24.57 10.03 58 191960 43223 64263491
Neurosis 24.47 10.03 15 192003 377 64306337
Right ventricular failure 24.41 10.03 17 192001 21454 64285260
Pathogen resistance 24.41 10.03 4 192014 12539 64294175
Myelosuppression 24.39 10.03 21 191997 23809 64282905
Tubulointerstitial nephritis 24.18 10.03 34 191984 30875 64275839
Aspartate aminotransferase increased 24.06 10.03 234 191784 119554 64187160
Toxic encephalopathy 23.99 10.03 74 191944 9741 64296973
Cardiomegaly 23.86 10.03 136 191882 23548 64283166
Pain in jaw 23.63 10.03 54 191964 40701 64266013
Opisthotonus 23.57 10.03 18 192000 653 64306061
Thrombosis 23.57 10.03 119 191899 70523 64236191
Nodule 23.51 10.03 12 192006 17935 64288779
Liver function test increased 23.31 10.03 35 191983 30935 64275779
Haematotoxicity 23.20 10.03 5 192013 12891 64293823
Tardive dyskinesia 23.18 10.03 70 191948 9108 64297606
Muscle twitching 23.18 10.03 115 191903 18883 64287831
Somatic delusion 23.12 10.03 18 192000 672 64306042
Upper respiratory tract infection 22.94 10.03 125 191893 72660 64234054
Aspergillus infection 22.92 10.03 10 192008 16369 64290345
Substance use disorder 22.80 10.03 14 192004 353 64306361
Adrenal insufficiency 22.79 10.03 20 191998 22467 64284247
Terminal dribbling 22.70 10.03 6 192012 11 64306703
Cerebral haemorrhage 22.70 10.03 77 191941 51013 64255701
Medication error 22.63 10.03 238 191780 49728 64256986
Rhesus antigen positive 22.62 10.03 10 192008 124 64306590
Paralysis 22.61 10.03 81 191937 11514 64295200
Lethargy 22.54 10.03 322 191696 72272 64234442
Tenosynovitis 22.53 10.03 4 192014 11829 64294885
Nervousness 22.49 10.03 158 191860 29398 64277316
Infective pulmonary exacerbation of cystic fibrosis 22.43 10.03 4 192014 11792 64294922
Clostridium difficile colitis 22.25 10.03 29 191989 27194 64279520
Hepatocellular injury 22.18 10.03 219 191799 45016 64261698
Personality change 22.14 10.03 66 191952 8527 64298187
Hostility 22.13 10.03 30 191988 2177 64304537
Suicide threat 22.09 10.03 8 192010 56 64306658
Electrocardiogram QRS complex shortened 22.09 10.03 17 192001 624 64306090
Thrombotic microangiopathy 22.02 10.03 11 192007 16644 64290070
Septic shock 22.02 10.03 204 191814 105233 64201481
Accident 22.01 10.03 57 191961 6789 64299925
Judgement impaired 21.74 10.03 21 191997 1052 64305662
Oral discharge 21.67 10.03 12 192006 248 64306466
Gait deviation 21.62 10.03 8 192010 60 64306654
Tuberculosis 21.62 10.03 6 192012 13032 64293682
Anaphylactic reaction 21.60 10.03 118 191900 68546 64238168
Patient restraint 21.55 10.03 9 192009 96 64306618
Sensory loss 21.53 10.03 73 191945 10096 64296618
Ulcer 21.48 10.03 22 191996 22968 64283746
Affective disorder 21.37 10.03 55 191963 6525 64300189
Flashback 21.37 10.03 12 192006 255 64306459
Crying 21.33 10.03 117 191901 19973 64286741
Oxygen saturation abnormal 21.04 10.03 38 191980 3533 64303181
Electrocardiogram QRS complex prolonged 21.04 10.03 68 191950 9176 64297538
Febrile bone marrow aplasia 21.01 10.03 4 192014 11251 64295463
Fibromyalgia 20.99 10.03 47 191971 35684 64271030
Upper gastrointestinal haemorrhage 20.96 10.03 46 191972 35174 64271540
Suspected suicide attempt 20.88 10.03 12 192006 267 64306447
Body temperature decreased 20.80 10.03 28 191990 25900 64280814
Paradoxical drug reaction 20.76 10.03 52 191966 6068 64300646
Delirium tremens 20.63 10.03 16 192002 594 64306120
Anticonvulsant drug level above therapeutic 20.57 10.03 20 191998 1010 64305704
Needle track marks 20.53 10.03 7 192011 40 64306674
Haemorrhage 20.48 10.03 145 191873 79206 64227508
Emotional distress 20.44 10.03 180 191838 35858 64270856
Joint stiffness 20.42 10.03 37 191981 30367 64276347
Diabetes insipidus 20.41 10.03 43 191975 4478 64302236
Negative symptoms in schizophrenia 20.40 10.03 9 192009 111 64306603
Hyperacusis 20.36 10.03 27 191991 1918 64304796
Myocardial infarction 20.36 10.03 359 191659 165462 64141252
Back pain 20.32 10.03 578 191440 249593 64057121
Drug withdrawal maintenance therapy 20.24 10.03 7 192011 42 64306672
Morbid thoughts 20.22 10.03 17 192001 709 64306005
Sinus bradycardia 20.21 10.03 127 191891 22766 64283948
Hallucination, visual 20.14 10.03 147 191871 27687 64279027
Staring 20.10 10.03 30 191988 2380 64304334
Poor venous access 20.06 10.03 6 192012 12411 64294303
Neutrophil count increased 20.00 10.03 136 191882 25038 64281676
Urine sodium increased 19.91 10.03 10 192008 168 64306546
Distractibility 19.82 10.03 16 192002 630 64306084
Conversion disorder 19.77 10.03 25 191993 1694 64305020
Pulmonary contusion 19.61 10.03 8 192010 80 64306634
Gallbladder cholesterolosis 19.55 10.03 15 192003 548 64306166
Swollen tongue 19.52 10.03 174 191844 34780 64271934
Hypotension 19.46 10.03 1350 190668 379624 63927090
Diverticulitis 19.43 10.03 55 191963 38563 64268151
Slow speech 19.39 10.03 27 191991 2010 64304704
Cytokine release syndrome 19.38 10.03 20 191998 20809 64285905
Hypocalcaemia 19.19 10.03 62 191956 41691 64265023
Oropharyngeal oedema 19.17 10.03 11 192007 244 64306470
Trismus 19.16 10.03 44 191974 4857 64301857
Uveitis 19.02 10.03 7 192011 12701 64294013
Frequent bowel movements 18.89 10.03 16 192002 18289 64288425
Circulatory collapse 18.88 10.03 168 191850 33564 64273150
Tissue infiltration 18.86 10.03 15 192003 578 64306136
Cardiac arrest neonatal 18.77 10.03 6 192012 27 64306687
Refraction disorder 18.75 10.03 7 192011 54 64306660
Squamous cell carcinoma of skin 18.72 10.03 6 192012 11870 64294844
Breathing-related sleep disorder 18.71 10.03 10 192008 192 64306522
Muscle tightness 18.65 10.03 74 191944 11041 64295673
Galactorrhoea 18.64 10.03 34 191984 3185 64303529
Balance disorder 18.53 10.03 352 191666 83574 64223140
Suspected counterfeit product 18.52 10.03 14 192004 500 64306214
Lactic acidosis 18.52 10.03 107 191911 61303 64245411
Haemoptysis 18.50 10.03 79 191939 48969 64257745
Neoplasm malignant 18.48 10.03 28 191990 24660 64282054
Delusion of reference 18.48 10.03 9 192009 141 64306573
Accommodation disorder 18.47 10.03 14 192004 502 64306212
Hypersomnia 18.43 10.03 111 191907 19606 64287108
Borderline personality disorder 18.36 10.03 17 192001 807 64305907
Sensory disturbance 18.33 10.03 83 191935 13125 64293589
Marchiafava-Bignami disease 18.32 10.03 5 192013 11 64306703
Drug tolerance increased 18.25 10.03 15 192003 606 64306108
Priapism 18.20 10.03 38 191980 3932 64302782
Skin necrosis 18.16 10.03 10 192008 14319 64292395
Sluggishness 18.01 10.03 47 191971 5623 64301091
Gait disturbance 18.00 10.03 654 191364 171501 64135213
Bradycardia foetal 17.96 10.03 8 192010 101 64306613
Hanging 17.96 10.03 8 192010 101 64306613
Social anxiety disorder 17.88 10.03 13 192005 437 64306277
Lid lag 17.81 10.03 7 192011 63 64306651
Therapy interrupted 17.80 10.03 20 191998 20016 64286698
Blood osmolarity decreased 17.78 10.03 20 191998 1198 64305516
Learning disorder 17.77 10.03 14 192004 532 64306182
Aphasia 17.66 10.03 193 191825 40713 64266001
Joint effusion 17.66 10.03 9 192009 13464 64293250
Decreased interest 17.60 10.03 34 191984 3326 64303388
Negativism 17.56 10.03 16 192002 744 64305970
Weight increased 17.56 10.03 492 191526 212856 64093858
Thymus disorder 17.54 10.03 10 192008 219 64306495
Musculoskeletal pain 17.53 10.03 156 191862 81138 64225576
Osteonecrosis 17.53 10.03 36 191982 28193 64278521
Blepharospasm 17.50 10.03 34 191984 3341 64303373
Alpha 1 microglobulin increased 17.43 10.03 7 192011 67 64306647
Major depression 17.34 10.03 57 191961 7759 64298955
Alcohol withdrawal syndrome 17.31 10.03 24 191994 1779 64304935
Erectile dysfunction 17.27 10.03 79 191939 12548 64294166
Generalised oedema 17.26 10.03 22 191996 20831 64285883
Myocarditis 17.26 10.03 98 191920 16945 64289769
Hypotensive crisis 17.25 10.03 7 192011 69 64306645
Fear 17.25 10.03 111 191907 20060 64286654
Facial spasm 17.22 10.03 15 192003 657 64306057
Tendonitis 17.21 10.03 21 191997 20261 64286453
Posturing 17.19 10.03 18 192000 994 64305720
Claustrophobia 17.19 10.03 17 192001 877 64305837
Theft 17.18 10.03 10 192008 228 64306486
Haematocrit decreased 17.15 10.03 94 191924 54561 64252153
Drug eruption 17.07 10.03 53 191965 36083 64270631
Poverty of speech 17.05 10.03 14 192004 565 64306149
Illogical thinking 16.90 10.03 7 192011 73 64306641
Pleurothotonus 16.87 10.03 27 191991 2275 64304439
Angina pectoris 16.77 10.03 73 191945 45008 64261706
Basal ganglion degeneration 16.70 10.03 12 192006 396 64306318
Liver disorder 16.61 10.03 92 191926 53259 64253455
Libido disorder 16.58 10.03 10 192008 244 64306470
Blood alcohol increased 16.56 10.03 19 191999 1163 64305551
Emotional poverty 16.53 10.03 15 192003 694 64306020
Gastrointestinal motility disorder 16.52 10.03 43 191975 5136 64301578
Penile haemorrhage 16.50 10.03 13 192005 494 64306220
Eosinophilia 16.50 10.03 58 191960 38018 64268696
Osmolar gap abnormal 16.42 10.03 7 192011 79 64306635
Hepatic necrosis 16.36 10.03 59 191959 8414 64298300
Bronchial secretion retention 16.32 10.03 28 191990 2499 64304215
Sputum culture positive 16.32 10.03 31 191987 2995 64303719
Diet refusal 16.31 10.03 16 192002 817 64305897
Carcinoid tumour of the stomach 16.29 10.03 9 192009 185 64306529
Osteoarthritis 16.22 10.03 116 191902 63220 64243494
Foetal exposure during pregnancy 16.21 10.03 39 191979 4437 64302277
Base excess 16.18 10.03 7 192011 82 64306632
Heart rate decreased 16.05 10.03 97 191921 54970 64251744
Analgesic drug level above therapeutic 16.04 10.03 12 192006 422 64306292
Colon cancer 15.98 10.03 9 192009 12730 64293984
Blood pressure diastolic increased 15.97 10.03 6 192012 10746 64295968
Enterochromaffin cell hyperplasia 15.96 10.03 7 192011 85 64306629
Pulmonary hypertension 15.96 10.03 70 191948 43069 64263645
Homicidal ideation 15.91 10.03 32 191986 3225 64303489
Proteinuria 15.85 10.03 37 191981 27686 64279028
Movement disorder 15.81 10.03 116 191902 21884 64284830
Rash maculo-papular 15.81 10.03 79 191939 46947 64259767
Oral discomfort 15.78 10.03 58 191960 8348 64298366
Urine osmolarity increased 15.78 10.03 10 192008 267 64306447
Full blood count decreased 15.60 10.03 27 191991 22555 64284159
Dyspraxia 15.58 10.03 10 192008 273 64306441
Acne 15.58 10.03 28 191990 23053 64283661
Cyclothymic disorder 15.51 10.03 9 192009 204 64306510
Adverse drug reaction 15.50 10.03 76 191942 45388 64261326
Oral pain 15.48 10.03 37 191981 27456 64279258
Drug screen false positive 15.43 10.03 17 192001 995 64305719
Live birth 15.43 10.03 7 192011 11197 64295517
Hereditary angioedema 15.38 10.03 35 191983 3841 64302873
Allodynia 15.30 10.03 19 191999 1264 64305450
Somatic symptom disorder 15.22 10.03 23 191995 1845 64304869
Alanine aminotransferase increased 15.21 10.03 307 191711 138724 64167990
Malaise 15.19 10.03 996 191022 395251 63911463
Pruritus genital 15.16 10.03 17 192001 1015 64305699
Periorbital swelling 15.14 10.03 23 191995 1853 64304861
Benzodiazepine drug level increased 15.13 10.03 9 192009 214 64306500
Clonus 15.07 10.03 46 191972 6021 64300693
Injection site haemorrhage 15.04 10.03 31 191987 24247 64282467
Right ventricular dilatation 15.04 10.03 20 191998 1425 64305289
Cerebrospinal fluid leakage 14.96 10.03 19 191999 1293 64305421
Enthesopathy 14.96 10.03 5 192013 9633 64297081
Basilar migraine 14.89 10.03 6 192012 58 64306656
Right ventricular hypertrophy 14.87 10.03 19 191999 1301 64305413
Ischaemic stroke 14.86 10.03 41 191977 28994 64277720
Congestive hepatopathy 14.80 10.03 35 191983 3938 64302776
Wrong rate 14.80 10.03 6 192012 59 64306655
Femoral nerve palsy 14.80 10.03 6 192012 59 64306655
Pupillary reflex impaired 14.78 10.03 30 191988 3043 64303671
Alcohol intolerance 14.70 10.03 11 192007 387 64306327
Premature labour 14.66 10.03 53 191965 7567 64299147
Mucosal erosion 14.61 10.03 23 191995 1911 64304803
Substance-induced psychotic disorder 14.58 10.03 28 191990 2727 64303987
Thoracic outlet syndrome 14.54 10.03 6 192012 62 64306652
Enteritis 14.49 10.03 9 192009 12068 64294646
Pneumonia bacterial 14.49 10.03 14 192004 15021 64291693
Panic reaction 14.49 10.03 35 191983 3992 64302722
Myocarditis septic 14.46 10.03 5 192013 30 64306684
Hyponatraemic coma 14.46 10.03 5 192013 30 64306684
Intestinal atony 14.46 10.03 3 192015 0 64306714
Myofascial pain syndrome 14.45 10.03 22 191996 1776 64304938
Affect lability 14.41 10.03 59 191959 8931 64297783
Crystalluria 14.40 10.03 15 192003 823 64305891
Cerebellar syndrome 14.35 10.03 40 191978 4976 64301738
Tinnitus 14.26 10.03 160 191858 33973 64272741
Pneumoconiosis 14.24 10.03 9 192009 239 64306475
Intervertebral disc disorder 14.21 10.03 37 191981 4420 64302294
Hypergastrinaemia 14.16 10.03 8 192010 172 64306542
Pneumonia viral 14.14 10.03 3 192015 7819 64298895
Drug level above therapeutic 14.14 10.03 49 191969 6852 64299862
Femur fracture 14.13 10.03 53 191965 34082 64272632
Ileus paralytic 14.10 10.03 56 191962 8359 64298355
Blood immunoglobulin M decreased 14.09 10.03 16 192002 968 64305746
Bradycardia 14.09 10.03 456 191562 117763 64188951
Reaction to excipient 13.96 10.03 19 191999 1384 64305330
Flat affect 13.91 10.03 22 191996 1835 64304879
Distal intestinal obstruction syndrome 13.90 10.03 13 192005 625 64306089
Antipsychotic drug level above therapeutic 13.88 10.03 22 191996 1839 64304875
Foetal death 13.84 10.03 44 191974 5886 64300828
Full blood count abnormal 13.80 10.03 44 191974 29713 64277001
Skin reaction 13.75 10.03 10 192008 12342 64294372
Feeling drunk 13.71 10.03 35 191983 4132 64302582
Diabetes mellitus 13.71 10.03 129 191889 66345 64240369
Injection site rash 13.67 10.03 16 192002 15726 64290988
Selective mutism 13.67 10.03 6 192012 73 64306641
Inappropriate affect 13.67 10.03 18 192000 1270 64305444
Obsessive thoughts 13.67 10.03 16 192002 1001 64305713
Guillain-Barre syndrome 13.66 10.03 3 192015 7632 64299082
Anxiety disorder 13.61 10.03 33 191985 3772 64302942
Metastases to bone 13.61 10.03 25 191993 20410 64286304
Drug resistance 13.57 10.03 56 191962 35046 64271668
Pulmonary alveolar haemorrhage 13.54 10.03 6 192012 9732 64296982
Pancreatic carcinoma 13.49 10.03 7 192011 10366 64296348
Purpura 13.46 10.03 19 191999 17227 64289487
Lower gastrointestinal haemorrhage 13.41 10.03 13 192005 13926 64292788
Oromandibular dystonia 13.34 10.03 15 192003 898 64305816
Hip fracture 13.33 10.03 39 191979 27060 64279654
Blood loss anaemia 13.32 10.03 13 192005 13879 64292835
Lactate pyruvate ratio increased 13.25 10.03 6 192012 79 64306635
Diabetic ketoacidosis 13.24 10.03 45 191973 29800 64276914
Antasthmatic drug level 13.23 10.03 5 192013 40 64306674
Hyperbilirubinaemia 13.20 10.03 27 191991 21178 64285536
Porphyria 13.20 10.03 8 192010 197 64306517
Drug-device interaction 13.18 10.03 6 192012 80 64306634
Urinary hesitation 13.16 10.03 31 191987 3479 64303235
Chronic fatigue syndrome 13.15 10.03 17 192001 1178 64305536
Blood sodium decreased 13.15 10.03 140 191878 29342 64277372
Oral herpes 13.13 10.03 29 191989 22123 64284591
Panniculitis 13.11 10.03 5 192013 8874 64297840
Communication disorder 13.11 10.03 32 191986 3674 64303040
Reflexes abnormal 13.04 10.03 14 192004 796 64305918
Enterocolitis 13.03 10.03 10 192008 12008 64294706
Diastolic hypotension 13.03 10.03 7 192011 136 64306578
Hypomagnesaemia 13.02 10.03 62 191956 37314 64269400
Kidney transplant rejection 13.01 10.03 6 192012 9505 64297209
Regressive behaviour 12.99 10.03 6 192012 83 64306631
Dry skin 12.95 10.03 94 191924 51067 64255647
Acidosis 12.88 10.03 94 191924 17701 64289013
Taste disorder 12.82 10.03 6 192012 9427 64297287
Analgesic drug level 12.82 10.03 5 192013 44 64306670
Tooth hypoplasia 12.78 10.03 8 192010 209 64306505
Hypertension 12.77 10.03 636 191382 258625 64048089
Ejaculation delayed 12.76 10.03 7 192011 142 64306572
Cerebral congestion 12.72 10.03 5 192013 45 64306669
Intestinal pseudo-obstruction 12.71 10.03 22 191996 1978 64304736
Emotional disorder of childhood 12.70 10.03 4 192014 17 64306697
Quadriparesis 12.70 10.03 27 191991 2830 64303884
Terminal insomnia 12.68 10.03 15 192003 949 64305765
Chest pain 12.59 10.03 574 191444 235406 64071308
Lack of spontaneous speech 12.58 10.03 8 192010 215 64306499
Libido decreased 12.57 10.03 37 191981 4747 64301967
Partial seizures 12.55 10.03 49 191969 7258 64299456
Protrusion tongue 12.54 10.03 10 192008 387 64306327
Acute generalised exanthematous pustulosis 12.52 10.03 14 192004 14044 64292670
Bruxism 12.51 10.03 31 191987 3593 64303121
Rebound psychosis 12.50 10.03 7 192011 148 64306566
Second primary malignancy 12.47 10.03 11 192007 12326 64294388
Thyroid adenoma 12.46 10.03 7 192011 149 64306565
Clonic convulsion 12.44 10.03 16 192002 1103 64305611
Pain threshold decreased 12.39 10.03 3 192015 3 64306711
Device related infection 12.39 10.03 48 191970 30578 64276136
Delusional disorder, unspecified type 12.38 10.03 13 192005 720 64305994
Cerebrovascular stenosis 12.37 10.03 7 192011 151 64306563
Blood bicarbonate decreased 12.36 10.03 37 191981 4792 64301922
Adverse event 12.34 10.03 68 191950 39421 64267293
Labelled drug-food interaction issue 12.34 10.03 4 192014 19 64306695
Osteoporosis 12.33 10.03 74 191944 42006 64264708
Food allergy 12.31 10.03 4 192014 7847 64298867
Foaming at mouth 12.29 10.03 20 191998 1709 64305005
Breast cancer 12.23 10.03 45 191973 29103 64277611
Haematoma 12.19 10.03 84 191934 46166 64260548
Device difficult to use 12.18 10.03 7 192011 9791 64296923
Withdrawal catatonia 12.17 10.03 7 192011 156 64306558
Squamous cell carcinoma 12.15 10.03 14 192004 13855 64292859
Orthopnoea 12.13 10.03 6 192012 9128 64297586
Dermatitis acneiform 12.06 10.03 5 192013 8438 64298276
Aplasia pure red cell 12.06 10.03 3 192015 7011 64299703
Nephropathy toxic 12.05 10.03 21 191997 17493 64289221
Muscle spasticity 12.04 10.03 88 191930 16581 64290133
Refusal of treatment by patient 12.02 10.03 53 191965 8286 64298428
Drug tolerance decreased 12.02 10.03 3 192015 6995 64299719
Herbal interaction 12 10.03 10 192008 412 64306302
Polyarthritis 11.99 10.03 7 192011 9708 64297006
Subdural haematoma 11.98 10.03 43 191975 28011 64278703
Chemical poisoning 11.93 10.03 7 192011 162 64306552
Left ventricular hypertrophy 11.92 10.03 58 191960 9448 64297266
Mood altered 11.91 10.03 85 191933 15894 64290820
Physical abuse 11.86 10.03 4 192014 22 64306692
Myositis 11.85 10.03 19 191999 16358 64290356
Tongue discolouration 11.83 10.03 29 191989 3339 64303375
Polyneuropathy 11.82 10.03 26 191992 19868 64286846
Illness anxiety disorder 11.80 10.03 8 192010 240 64306474
Contusion 11.77 10.03 254 191764 113711 64193003
Bone pain 11.76 10.03 88 191930 47484 64259230
Formication 11.74 10.03 34 191984 4323 64302391
Metastases to lung 11.73 10.03 17 192001 15247 64291467
Intraocular pressure increased 11.73 10.03 5 192013 8297 64298417
Uterine enlargement 11.70 10.03 13 192005 768 64305946
Cholangitis 11.70 10.03 9 192009 10793 64295921
Coma scale 11.68 10.03 5 192013 57 64306657
Bronchiectasis 11.62 10.03 15 192003 14125 64292589
Neurodegenerative disorder 11.60 10.03 10 192008 432 64306282
Personal relationship issue 11.56 10.03 7 192011 172 64306542
Blood osmolarity increased 11.54 10.03 11 192007 542 64306172
Blood citric acid increased 11.53 10.03 5 192013 59 64306655
Pericardial effusion 11.51 10.03 69 191949 39185 64267529
Facial nerve disorder 11.51 10.03 12 192006 659 64306055
Obsessive-compulsive disorder 11.47 10.03 36 191982 4782 64301932
Azotaemia 11.46 10.03 4 192014 7498 64299216
Flushing 11.41 10.03 165 191853 78483 64228231
Dry eye 11.41 10.03 46 191972 28973 64277741
Jaundice 11.40 10.03 91 191927 48421 64258293
Immunodeficiency 11.40 10.03 19 191999 16105 64290609
Petechiae 11.36 10.03 24 191994 18602 64288112
Blister 11.35 10.03 171 191847 80796 64225918
Hypoaesthesia oral 11.34 10.03 66 191952 11514 64295200
Tenderness 11.34 10.03 26 191992 19576 64287138
Lupus-like syndrome 11.34 10.03 6 192012 8785 64297929
Gastric lavage 11.31 10.03 5 192013 62 64306652
Atopic keratoconjunctivitis 11.30 10.03 4 192014 26 64306688
Prostatic specific antigen increased 11.26 10.03 6 192012 8754 64297960
Coeliac disease 11.24 10.03 4 192014 7408 64299306
Blood glucose increased 11.19 10.03 215 191803 97858 64208856
Binge drinking 11.18 10.03 3 192015 6 64306708
Cardiac dysfunction 11.18 10.03 27 191991 3079 64303635
Gastrooesophageal reflux disease 11.18 10.03 177 191841 82966 64223748
Dysgeusia 11.17 10.03 88 191930 46959 64259755
Duodenal ulcer 11.17 10.03 16 192002 14419 64292295
Metastases to lymph nodes 11.17 10.03 6 192012 8711 64298003
Sensation of foreign body 11.15 10.03 34 191984 4448 64302266
Seizure cluster 11.14 10.03 9 192009 355 64306359
Dyspepsia 11.13 10.03 170 191848 80142 64226572
Sexually inappropriate behaviour 11.10 10.03 10 192008 458 64306256
Enterococcal infection 11.10 10.03 15 192003 13851 64292863
Abortion spontaneous 11.10 10.03 38 191980 25105 64281609
Rash erythematous 11.07 10.03 92 191926 48541 64258173
Paraesthesia 11.04 10.03 498 191520 134024 64172690
Crime 11.03 10.03 5 192013 66 64306648
Maternal exposure during pregnancy 11.01 10.03 210 191808 95674 64211040
Throat irritation 10.97 10.03 55 191963 32656 64274058
Blood prolactin increased 10.96 10.03 29 191989 3499 64303215
Pseudomonas infection 10.94 10.03 23 191995 17860 64288854
Choking 10.94 10.03 61 191957 10477 64296237
Ovarian cyst 10.92 10.03 10 192008 11008 64295706
Eye irritation 10.92 10.03 19 191999 15837 64290877
Stereotypy 10.91 10.03 13 192005 829 64305885
Cholinergic syndrome 10.89 10.03 13 192005 830 64305884
Hyperchloraemia 10.89 10.03 14 192004 965 64305749
Head titubation 10.87 10.03 13 192005 832 64305882
Intestinal perforation 10.86 10.03 18 192000 15295 64291419
Enuresis 10.85 10.03 25 191993 2765 64303949
Neuromuscular toxicity 10.85 10.03 7 192011 193 64306521
Bladder cancer 10.83 10.03 10 192008 10964 64295750
Bacterial infection 10.81 10.03 38 191980 24912 64281802
Ductus arteriosus premature closure 10.81 10.03 4 192014 30 64306684
Red blood cell count decreased 10.81 10.03 92 191926 48294 64258420
Lung disorder 10.79 10.03 122 191896 60578 64246136
Eosinophilic myocarditis 10.78 10.03 13 192005 839 64305875
Hyperreflexia 10.74 10.03 46 191972 7102 64299612
Pancreatitis acute 10.72 10.03 79 191939 42776 64263938
Hypersensitivity myocarditis 10.64 10.03 5 192013 72 64306642
Skull fractured base 10.63 10.03 8 192010 284 64306430
Post-traumatic stress disorder 10.55 10.03 32 191986 4173 64302541
Therapy partial responder 10.52 10.03 9 192009 10239 64296475
Impulsive behaviour 10.51 10.03 24 191994 2639 64304075
Bursitis 10.51 10.03 31 191987 21454 64285260
Peritonitis bacterial 10.49 10.03 7 192011 9036 64297678
Muscle spasms 10.49 10.03 517 191501 140506 64166208
Tarsal tunnel syndrome 10.45 10.03 10 192008 495 64306219
Cor pulmonale acute 10.45 10.03 11 192007 611 64306103
Impaired self-care 10.44 10.03 22 191996 2291 64304423
Cholelithiasis 10.44 10.03 192 191826 45314 64261400
Hyporesponsive to stimuli 10.43 10.03 19 191999 1778 64304936
Hepatitis B 10.42 10.03 5 192013 7740 64298974
Abdominal pain lower 10.38 10.03 42 191976 26427 64280287
Haemolytic anaemia 10.37 10.03 20 191998 16033 64290681
Oral tuberculosis 10.33 10.03 3 192015 9 64306705
Cardiac death 10.32 10.03 16 192002 1312 64305402
Aphthous ulcer 10.29 10.03 14 192004 12892 64293822
Foot deformity 10.29 10.03 21 191997 16483 64290231
Akinesia 10.27 10.03 26 191992 3053 64303661
Ventricular dyskinesia 10.24 10.03 9 192009 399 64306315
Sinus congestion 10.18 10.03 19 191999 15420 64291294
Pneumonia fungal 10.13 10.03 7 192011 8870 64297844
Therapy cessation 10.12 10.03 56 191962 32433 64274281
Hyporeflexia 10.10 10.03 27 191991 3277 64303437
Lacrimation increased 10.08 10.03 25 191993 18321 64288393
Ankylosing spondylitis 10.07 10.03 6 192012 8228 64298486
Kidney enlargement 10.06 10.03 14 192004 1042 64305672

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N05BA01 NERVOUS SYSTEM
PSYCHOLEPTICS
ANXIOLYTICS
Benzodiazepine derivatives
FDA CS M0002356 Benzodiazepines
MeSH PA D000759 Adjuvants, Anesthesia
MeSH PA D000777 Anesthetics
MeSH PA D018686 Anesthetics, Intravenous
MeSH PA D014151 Anti-Anxiety Agents
MeSH PA D000927 Anticonvulsants
MeSH PA D000932 Antiemetics
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D018682 GABA Agents
MeSH PA D018757 GABA Modulators
MeSH PA D005765 Gastrointestinal Agents
MeSH PA D006993 Hypnotics and Sedatives
MeSH PA D009125 Muscle Relaxants, Central
MeSH PA D009465 Neuromuscular Agents
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D011619 Psychotropic Drugs
MeSH PA D014149 Tranquilizing Agents
FDA EPC N0000175694 Benzodiazepine
CHEBI has role CHEBI:35474 anti-anxiety agents
CHEBI has role CHEBI:35623 anticonvulsants
CHEBI has role CHEBI:35703 Xenobiotic
CHEBI has role CHEBI:35717 hypnotics
CHEBI has role CHEBI:78298 environmental contaminants

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Alcohol withdrawal delirium indication 8635005
Anxiety indication 48694002
Sedation indication 72641008
Tetanus indication 76902006 DOID:11338
Epilepsy indication 84757009 DOID:1826
Alcohol withdrawal syndrome indication 191480000
Spasticity indication 221360009
Status epilepticus indication 230456007 DOID:1824
Induce Anterograde Amnesia indication
Preoperative Anxiety indication
Panic disorder off-label use 371631005 DOID:594
Cocaine-Associated Acute Ischemic Heart Disease off-label use
Disorder of lung contraindication 19829001 DOID:850
Alcohol intoxication contraindication 25702006
Depressive disorder contraindication 35489007
Acute nephropathy contraindication 58574008
Hepatic failure contraindication 59927004
Substance abuse contraindication 66214007
Sleep apnea contraindication 73430006 DOID:0050847
Decreased respiratory function contraindication 80954004
Open-angle glaucoma contraindication 84494001 DOID:1067
Myasthenia gravis contraindication 91637004 DOID:437
Hypoalbuminemia contraindication 119247004
Disease of liver contraindication 235856003 DOID:409
Pregnancy, function contraindication 289908002
Severe chronic obstructive pulmonary disease contraindication 313299006
Angle-closure glaucoma contraindication 392291006 DOID:13550
Breastfeeding (mother) contraindication 413712001




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.06 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
10MG/SPRAY VALTOCO NEURELIS INC N211635 Jan. 10, 2020 RX SPRAY NASAL 8927497 July 21, 2025 NASAL ADMINISTRATION OF DIAZEPAM FOR TREATMENT OF INTERMITTENT, STEREOTYPIC EPISODES OF FREQUENT SEIZURE ACTIVITY IN PATIENTS 6 YEARS OF AGE AND OLDER
5MG/SPRAY VALTOCO NEURELIS INC N211635 Jan. 10, 2020 RX SPRAY NASAL 8927497 July 21, 2025 NASAL ADMINISTRATION OF DIAZEPAM FOR TREATMENT OF INTERMITTENT, STEREOTYPIC EPISODES OF FREQUENT SEIZURE ACTIVITY IN PATIENTS 6 YEARS OF AGE AND OLDER
7.5MG/SPRAY VALTOCO NEURELIS INC N211635 Jan. 10, 2020 RX SPRAY NASAL 8927497 July 21, 2025 NASAL ADMINISTRATION OF DIAZEPAM FOR TREATMENT OF INTERMITTENT, STEREOTYPIC EPISODES OF FREQUENT SEIZURE ACTIVITY IN PATIENTS 6 YEARS OF AGE AND OLDER

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
10MG/SPRAY VALTOCO NEURELIS INC N211635 Jan. 10, 2020 RX SPRAY NASAL Jan. 10, 2023 NEW PRODUCT
5MG/SPRAY VALTOCO NEURELIS INC N211635 Jan. 10, 2020 RX SPRAY NASAL Jan. 10, 2023 NEW PRODUCT
7.5MG/SPRAY VALTOCO NEURELIS INC N211635 Jan. 10, 2020 RX SPRAY NASAL Jan. 10, 2023 NEW PRODUCT
10MG/SPRAY VALTOCO NEURELIS INC N211635 Jan. 10, 2020 RX SPRAY NASAL Jan. 10, 2027 INDICATED FOR THE ACUTE TX OF INTERMITTENT, STEREOTYPIC EPISODES OF FREQUENT SEIZURE ACTIVITY (I.E. SEIZURE CLUSTERS, ACUTE REPETITIVE SEIZURES) THAT ARE DISTINCT FROM A PATIENT’S USUAL SEIZURE PATTERN IN PATIENTS WITH EPILEPSY 6 YEARS OF AGE AND OLDER
5MG/SPRAY VALTOCO NEURELIS INC N211635 Jan. 10, 2020 RX SPRAY NASAL Jan. 10, 2027 INDICATED FOR THE ACUTE TX OF INTERMITTENT, STEREOTYPIC EPISODES OF FREQUENT SEIZURE ACTIVITY (I.E. SEIZURE CLUSTERS, ACUTE REPETITIVE SEIZURES) THAT ARE DISTINCT FROM A PATIENT’S USUAL SEIZURE PATTERN IN PATIENTS WITH EPILEPSY 6 YEARS OF AGE AND OLDER
7.5MG/SPRAY VALTOCO NEURELIS INC N211635 Jan. 10, 2020 RX SPRAY NASAL Jan. 10, 2027 INDICATED FOR THE ACUTE TX OF INTERMITTENT, STEREOTYPIC EPISODES OF FREQUENT SEIZURE ACTIVITY (I.E. SEIZURE CLUSTERS, ACUTE REPETITIVE SEIZURES) THAT ARE DISTINCT FROM A PATIENT’S USUAL SEIZURE PATTERN IN PATIENTS WITH EPILEPSY 6 YEARS OF AGE AND OLDER

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
GABA A receptor alpha-5/beta-2/gamma-3 Ion channel POSITIVE ALLOSTERIC MODULATOR Ki 7.20 WOMBAT-PK CHEMBL
GABA-A receptor alpha-1/beta-2/gamma-2 Ion channel POSITIVE ALLOSTERIC MODULATOR EC50 7.14 WOMBAT-PK CHEMBL
GABA-A receptor alpha-2/beta-3/gamma-2 Ion channel POSITIVE ALLOSTERIC MODULATOR Ki 7.70 WOMBAT-PK CHEMBL
GABA-A receptor alpha-3/beta-3/gamma-2 Ion channel POSITIVE ALLOSTERIC MODULATOR Ki 7.65 WOMBAT-PK CHEMBL
GABA-A receptor alpha-5/beta-3/gamma-2 Ion channel POSITIVE ALLOSTERIC MODULATOR Ki 7.96 WOMBAT-PK CHEMBL
GABA-A receptor alpha-1/beta-2/gamma-3 Ion channel POSITIVE ALLOSTERIC MODULATOR Ki 6.71 WOMBAT-PK CHEMBL
GABA-A receptor alpha-1/beta-3/gamma-2 Ion channel POSITIVE ALLOSTERIC MODULATOR Ki 7.85 WOMBAT-PK CHEMBL
GABA A receptor alpha-3/beta-2/gamma-2 Ion channel POSITIVE ALLOSTERIC MODULATOR Ki 7.94 WOMBAT-PK CHEMBL
GABA A receptor alpha-3/beta-2/gamma-3 Ion channel POSITIVE ALLOSTERIC MODULATOR Ki 6.67 WOMBAT-PK CHEMBL
GABA A receptor alpha-5/beta-3/gamma-3 Ion channel POSITIVE ALLOSTERIC MODULATOR Ki 7.20 WOMBAT-PK CHEMBL
GABA A receptor alpha-5/beta-2/gamma-2 Ion channel POSITIVE ALLOSTERIC MODULATOR Ki 8.00 WOMBAT-PK CHEMBL
Gamma-aminobutyric acid receptor subunit alpha-5 Ion channel Kd 7.64 CHEMBL
Cytochrome P450 3A4 Enzyme Ki 4.42 WOMBAT-PK
Alpha-1A adrenergic receptor GPCR ALLOSTERIC MODULATOR Ki 4.10 IUPHAR
Adenosine receptor A3 GPCR IC50 7.92 CHEMBL
Aldo-keto reductase family 1 member C1 Enzyme IC50 5.25 CHEMBL
Aldo-keto reductase family 1 member C2 Enzyme IC50 5.62 CHEMBL
Aldo-keto reductase family 1 member C3 Enzyme IC50 4.08 CHEMBL
Cholinesterase Enzyme Ki 7.37 CHEMBL
Gamma-aminobutyric acid receptor subunit alpha-1 Ion channel Ki 7.96 CHEMBL
Gamma-aminobutyric acid receptor subunit alpha-2 Ion channel Ki 7.82 CHEMBL
Gamma-aminobutyric acid receptor subunit alpha-5 Ion channel Ki 8.01 CHEMBL
GABA A receptor alpha-6/beta-2/gamma-2 Ion channel Ki 8.68 CHEMBL
GABA-A receptor; alpha-1/beta-2/gamma-2 Ion channel Ki 7.92 CHEMBL
GABA-A receptor; anion channel Ion channel Ki 4.07 CHEMBL
GABA A receptor alpha-2/beta-2/gamma-2 Ion channel Ki 7.70 CHEMBL
GABA A receptor alpha-5/beta-3/gamma-2 Ion channel Ki 7.96 CHEMBL
GABA-A receptor; anion channel Ion channel Ki 8.54 CHEMBL
GABA-A receptor; anion channel Ion channel Ki 8 CHEMBL
GABA A receptor alpha-3/beta-2/gamma-2 Ion channel Ki 7.86 CHEMBL
Fatty acid-binding protein, liver Unclassified Ki 6.27 CHEMBL
Acetylcholinesterase Enzyme Ki 4.89 CHEMBL
Translocator protein Membrane receptor Kd 6.67 CHEMBL
Thyrotropin-releasing hormone receptor GPCR ANTAGONIST Ki 5.15 IUPHAR

External reference:

IDSource
4017796 VUID
N0000146157 NUI
D00293 KEGG_DRUG
202472 RXNORM
4017796 VANDF
C0012010 UMLSCUI
CHEBI:49575 CHEBI
DZP PDB_CHEM_ID
CHEMBL12 ChEMBL_ID
DB00829 DRUGBANK_ID
D003975 MESH_DESCRIPTOR_UI
3016 PUBCHEM_CID
3364 IUPHAR_LIGAND_ID
1295 INN_ID
Q3JTX2Q7TU UNII
3018 MMSL
4573 MMSL
894 MMSL
d00148 MMSL
001461 NDDF
387264003 SNOMEDCT_US
48546005 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Diazepam Intensol HUMAN PRESCRIPTION DRUG LABEL 1 0054-3185 SOLUTION, CONCENTRATE 5 mg ORAL ANDA 24 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0054-3188 SOLUTION 5 mg ORAL ANDA 26 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0054-3188 SOLUTION 5 mg ORAL ANDA 26 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0121-0905 SOLUTION 5 mg ORAL ANDA 24 sections
Valium HUMAN PRESCRIPTION DRUG LABEL 1 0140-0004 TABLET 2 mg ORAL NDA 28 sections
Valium HUMAN PRESCRIPTION DRUG LABEL 1 0140-0005 TABLET 5 mg ORAL NDA 28 sections
Valium HUMAN PRESCRIPTION DRUG LABEL 1 0140-0006 TABLET 10 mg ORAL NDA 28 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0172-3925 TABLET 2 mg ORAL ANDA 16 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0172-3926 TABLET 5 mg ORAL ANDA 16 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0172-3927 TABLET 10 mg ORAL ANDA 16 sections
Diastat HUMAN PRESCRIPTION DRUG LABEL 1 0187-0658 GEL 10 mg RECTAL NDA 19 sections
Diastat HUMAN PRESCRIPTION DRUG LABEL 1 0187-0659 GEL 20 mg RECTAL NDA 19 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0378-0271 TABLET 2 mg ORAL ANDA 28 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0378-0345 TABLET 5 mg ORAL ANDA 28 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0378-0477 TABLET 10 mg ORAL ANDA 28 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0404-9848 INJECTION, SOLUTION 5 mg INTRAVENOUS ANDA 15 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0409-1273 INJECTION, SOLUTION 5 mg INTRAMUSCULAR ANDA 21 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0409-1273 INJECTION, SOLUTION 5 mg INTRAMUSCULAR ANDA 21 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0409-3213 INJECTION, SOLUTION 5 mg INTRAMUSCULAR ANDA 20 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0409-3213 INJECTION, SOLUTION 5 mg INTRAMUSCULAR ANDA 20 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0409-3213 INJECTION, SOLUTION 5 mg INTRAMUSCULAR ANDA 20 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0527-1767 SOLUTION 5 mg ORAL ANDA 21 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0527-1767 SOLUTION 5 mg ORAL ANDA 21 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0527-1768 SOLUTION, CONCENTRATE 5 mg ORAL ANDA 21 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0527-1768 SOLUTION, CONCENTRATE 5 mg ORAL ANDA 21 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0615-7799 TABLET 5 mg ORAL ANDA 16 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0615-7800 TABLET 10 mg ORAL ANDA 14 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0641-6244 INJECTION 5 mg INTRAMUSCULAR ANDA 16 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0904-5880 TABLET 5 mg ORAL ANDA 26 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0904-7117 SOLUTION 5 mg ORAL ANDA 26 sections