diazepam 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
diazepam derivatives 852 439-14-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • RO-5-2807
  • diazepam
  • valium
A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.
  • Molecular weight: 284.74
  • Formula: C16H13ClN2O
  • CLOGP: 2.96
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 0
  • TPSA: 32.67
  • ALOGS: -4.37
  • ROTB: 1
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
10 mg O
10 mg P
10 mg R

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 2.86 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 0.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 2.01 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 99 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 1 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 0.38 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.02 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 42 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 2.814 Moderate 0.73
caco2-efflux Caco-2 efflux ratio (BA/AB) 0.635 Moderate 0.73
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 68.549 10^-6 cm/s Moderate 0.73
dh-clint Dog hepatocyte intrinsic clearance 52.119 uL/min/10^6 cells Moderate 0.73
dppb Dog plasma protein binding (% unbound) 6.250 % Moderate 0.73
fcs-ppb Fetal calf serum protein binding (% unbound) 17.280 % Moderate 0.73
herg hERG pIC50 4.482 pIC50 Moderate 0.73
hh-clint Human hepatocyte intrinsic clearance 3.724 uL/min/10^6 cells Moderate 0.73
hlm-clint Human liver microsomal intrinsic clearance 8.222 uL/min/mg protein Moderate 0.73
hppb Human plasma protein binding (% unbound) 5.940 % Moderate 0.73
kinase-safety-class ACVR2B,CDK5,EIF2AK3,GRK2,MAPK7,PDK1,PDK2,PDK4,TTK 9
kinase-selectivity-class AXL,GRK2 2
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 0.497 High 1
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 0.419 Moderate 0.73
mh-clint Mouse hepatocyte intrinsic clearance 133.045 Moderate 0.73
mppb Mouse plasma protein binding (% unbound) 9.740 Moderate 0.73
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 0.733 Moderate 0.73
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 11.770 % Moderate 0.73
rat-kpuu-brain Rat brain Kpuu 1.186 % High 1
rh-clint Rat hepatocyte intrinsic clearance 78.705 uL/min/10^6 cells Moderate 0.73
rh-fuinc Rat hepatocyte fraction unbound in incubation 67.480 % Moderate 0.73
rppb Rat plasma protein binding (% unbound) 8.270 % Moderate 0.73
solubility-dd Solubility at pH 7.4 in DMSO 665.273 uM Moderate 0.73

Approvals:

DateAgencyCompanyOrphan
Nov. 15, 1963 FDA ROCHE

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug abuse 3684.13 9.74 2169 171557 80178 90374543
Toxicity to various agents 3440.74 9.74 3445 170281 284401 90170320
Intentional overdose 2280.23 9.74 1689 172037 92145 90362576
Completed suicide 2144.03 9.74 1955 171771 143103 90311618
Suicide attempt 1808.39 9.74 1347 172379 74052 90380669
Coma 1361.35 9.74 1122 172604 71510 90383211
Somnolence 1157.71 9.74 1697 172029 207387 90247334
Poisoning deliberate 901.89 9.74 496 173230 15990 90438731
Overdose 876.66 9.74 1283 172443 156426 90298295
Intentional self-injury 763.47 9.74 551 173175 28783 90425938
Respiratory arrest 727.04 9.74 563 173163 32748 90421973
Sopor 725.15 9.74 499 173227 24145 90430576
Drug withdrawal syndrome 701.05 9.74 519 173207 28204 90426517
Drug dependence 700.32 9.74 523 173203 28804 90425917
Depressed level of consciousness 662.13 9.74 756 172970 72028 90382693
Poisoning 656.02 9.74 392 173334 14825 90439896
Schizophrenia 645.04 9.74 385 173341 14529 90440192
Drug interaction 604.91 9.74 1511 172215 274942 90179779
Pemphigus 593.79 9.74 6 173720 326858 90127863
Agitation 580.18 9.74 679 173047 66419 90388302
Suicidal ideation 572.50 9.74 707 173019 73148 90381573
Synovitis 558.38 9.74 16 173710 329736 90124985
Infusion related reaction 548.01 9.74 75 173651 416705 90038016
Systemic lupus erythematosus 518.72 9.74 48 173678 361848 90092873
Cardio-respiratory arrest 501.58 9.74 612 173114 62528 90392193
Substance use disorder 480.68 9.74 171 173555 1849 90452872
Glossodynia 479.52 9.74 36 173690 321743 90132978
Miosis 476.85 9.74 270 173456 9214 90445507
Drug use disorder 475.61 9.74 258 173468 8085 90446636
Pericarditis 457.69 9.74 13 173713 270138 90184583
Contraindicated product administered 454.66 9.74 44 173682 320095 90134626
Psychotic disorder 448.75 9.74 415 173311 30815 90423906
Joint swelling 439.29 9.74 208 173518 503092 89951629
Anti-cyclic citrullinated peptide antibody positive 435.75 9.74 3 173723 236430 90218291
Intentional product misuse 432.32 9.74 683 173043 88921 90365800
Neuroleptic malignant syndrome 426.07 9.74 298 173428 14798 90439923
Arthropathy 418.10 9.74 95 173631 366147 90088574
Seizure 415.14 9.74 909 172817 151720 90303001
Cardiac arrest 411.63 9.74 729 172997 104206 90350515
Rheumatoid arthritis 408.10 9.74 97 173629 362517 90092204
Hand deformity 404.75 9.74 47 173679 296315 90158406
Helicobacter infection 399.47 9.74 7 173719 226843 90227878
Serotonin syndrome 390.05 9.74 420 173306 37467 90417254
Wound 385.36 9.74 60 173666 302920 90151801
Respiratory depression 383.53 9.74 283 173443 15292 90439429
Duodenal ulcer perforation 381.01 9.74 9 173717 221279 90233442
Folliculitis 356.98 9.74 7 173719 204346 90250375
Drug intolerance 356.46 9.74 208 173518 447383 90007338
Aggression 346.14 9.74 335 173391 26333 90428388
Sedation 339.66 9.74 440 173286 47731 90406990
Withdrawal syndrome 334.66 9.74 305 173421 22219 90432502
Treatment failure 332.78 9.74 86 173640 303842 90150879
Bradypnoea 322.33 9.74 164 173562 4494 90450227
Swelling 317.99 9.74 206 173520 418852 90035869
Alopecia 316.45 9.74 290 173436 494781 89959940
Rheumatoid factor positive 312.25 9.74 3 173723 171647 90283074
Hypomania 309.53 9.74 200 173526 8697 90446024
Abdominal discomfort 306.99 9.74 278 173448 477050 89977671
Therapeutic product effect decreased 301.09 9.74 80 173646 277491 90177230
Muscle injury 300.98 9.74 8 173718 176646 90278075
Substance abuse 285.61 9.74 159 173567 5247 90449474
Tremor 285.24 9.74 789 172937 152384 90302337
Nasopharyngitis 282.73 9.74 220 173506 406884 90047837
Altered state of consciousness 282.33 9.74 325 173401 31207 90423514
Impaired healing 266.61 9.74 61 173665 234138 90220583
Mydriasis 264.55 9.74 224 173502 14788 90439933
Stomatitis 264.32 9.74 98 173628 274600 90180121
Discomfort 260.41 9.74 100 173626 274235 90180486
Rash 255.90 9.74 735 172991 795365 89659356
Psoriatic arthropathy 247.23 9.74 66 173660 228269 90226452
Disturbance in attention 246.60 9.74 373 173353 46736 90407985
Hypersensitivity 246.20 9.74 306 173420 454371 90000350
Peripheral swelling 237.60 9.74 265 173461 412841 90041880
Sinusitis 234.88 9.74 188 173538 342900 90111821
Irritable bowel syndrome 234.19 9.74 55 173671 207393 90247328
Jaundice cholestatic 228.38 9.74 174 173552 9869 90444852
Tachycardia 226.30 9.74 741 172985 156932 90297789
General physical health deterioration 225.57 9.74 209 173517 354906 90099815
Urinary retention 219.43 9.74 314 173412 37430 90417291
C-reactive protein abnormal 216.19 9.74 6 173720 127423 90327298
Type 2 diabetes mellitus 215.80 9.74 61 173665 203183 90251538
Hypotension 203.36 9.74 1190 172536 324207 90130514
Gastrointestinal disorder 198.91 9.74 123 173603 256564 90198157
Infection 195.60 9.74 244 173482 361850 90092871
Nightmare 194.61 9.74 224 173502 21501 90433220
Lower respiratory tract infection 194.39 9.74 120 173606 250539 90204182
Status epilepticus 192.07 9.74 208 173518 18666 90436055
Arthralgia 189.35 9.74 809 172917 777713 89677008
Loss of consciousness 187.86 9.74 644 173082 139594 90315127
Liver injury 187.09 9.74 48 173678 170519 90284202
Cholelithiasis 187.03 9.74 350 173376 52156 90402565
Salivary hypersecretion 183.93 9.74 147 173579 8945 90445776
Fibromyalgia 181.56 9.74 84 173642 206185 90248536
Dissociation 174.34 9.74 126 173600 6589 90448132
Dysarthria 174.26 9.74 347 173379 54135 90400586
Accidental overdose 172.91 9.74 241 173485 28032 90426689
Bradyphrenia 171.14 9.74 131 173595 7481 90447240
Asphyxia 168.01 9.74 126 173600 6977 90447744
Panic attack 167.64 9.74 229 173497 26136 90428585
Joint range of motion decreased 167.56 9.74 29 173697 135614 90319107
Disorientation 165.85 9.74 301 173425 43813 90410908
Hepatic enzyme increased 164.35 9.74 274 173452 360462 90094259
Muscle rigidity 163.96 9.74 168 173558 14141 90440580
Restlessness 162.21 9.74 265 173461 35455 90419266
Product use issue 161.30 9.74 239 173487 329680 90125041
Dyskinesia 159.13 9.74 266 173460 36268 90418453
Drug withdrawal convulsions 156.35 9.74 70 173656 1430 90453291
Anxiety 155.73 9.74 1072 172654 308700 90146021
Extrapyramidal disorder 150.94 9.74 171 173555 16132 90438589
Inflammation 150.66 9.74 77 173649 178515 90276206
Ill-defined disorder 149.70 9.74 84 173642 184807 90269914
Dystonia 148.27 9.74 172 173554 16647 90438074
Psychomotor hyperactivity 147.84 9.74 151 173575 12662 90442059
Hypothermia 143.58 9.74 163 173563 15412 90439309
Pneumonia aspiration 143.44 9.74 271 173455 40669 90414052
Breast cancer stage III 143.15 9.74 4 173722 84443 90370278
Pulmonary fibrosis 139.52 9.74 20 173706 107483 90347238
Asthma-chronic obstructive pulmonary disease overlap syndrome 138.91 9.74 97 173629 4802 90449919
Bursitis 138.82 9.74 40 173686 131614 90323107
Irritability 138.75 9.74 247 173479 35415 90419306
Peripheral venous disease 138.58 9.74 5 173721 83916 90370805
Lip dry 137.73 9.74 16 173710 100939 90353782
Abnormal behaviour 135.57 9.74 191 173535 22437 90432284
Myoglobin urine present 135.23 9.74 52 173674 710 90454011
Generalised tonic-clonic seizure 134.84 9.74 241 173485 34662 90420059
Urticaria 134.72 9.74 246 173480 312488 90142233
Blister 134.33 9.74 175 173551 254823 90199898
Total lung capacity increased 132.15 9.74 95 173631 4926 90449795
Blood cholesterol increased 131.30 9.74 123 173603 207889 90246832
Speech disorder 131.23 9.74 278 173448 45307 90409414
Hallucination 130.91 9.74 348 173378 65611 90389110
Facet joint syndrome 130.78 9.74 17 173709 98372 90356349
Intentional product use issue 130.27 9.74 134 173592 216758 90237963
Mood swings 124.41 9.74 175 173551 20527 90434194
Reversible airways obstruction 123.35 9.74 65 173661 1918 90452803
Chemical submission 122.83 9.74 44 173682 486 90454235
Diarrhoea 122.53 9.74 1181 172545 938009 89516712
Exposure via ingestion 120.93 9.74 71 173655 2596 90452125
Wound infection 120.45 9.74 28 173698 106374 90348347
Vital capacity decreased 119.94 9.74 62 173664 1757 90452964
Pain 119.62 9.74 1278 172448 995063 89459658
Depersonalisation/derealisation disorder 117.42 9.74 59 173667 1573 90453148
Cogwheel rigidity 117.02 9.74 64 173662 2038 90452683
Derealisation 116.68 9.74 57 173669 1428 90453293
Hallucinations, mixed 116.54 9.74 94 173632 5795 90448926
Blood creatine phosphokinase increased 116.45 9.74 223 173503 33800 90420921
Electrocardiogram QT prolonged 116.23 9.74 354 173372 72102 90382619
Balance disorder 115.57 9.74 429 173297 96651 90358070
Mania 115.50 9.74 139 173587 13985 90440736
Drooling 115.06 9.74 84 173642 4462 90450259
Hypotonia 112.91 9.74 124 173602 11302 90443419
Gastric pH decreased 112.40 9.74 49 173677 937 90453784
Grip strength decreased 111.71 9.74 21 173705 92555 90362166
Hyperhidrosis 111.35 9.74 537 173189 135768 90318953
Drug ineffective 111.26 9.74 1928 171798 1382370 89072351
Emotional disorder 110.42 9.74 140 173586 14857 90439864
Coma scale abnormal 109.64 9.74 89 173637 5537 90449184
Arthritis 109.07 9.74 96 173630 167219 90287502
Pruritus 108.61 9.74 602 173124 540923 89913798
Ataxia 107.66 9.74 152 173574 17890 90436831
Hypercholesterolaemia 107.57 9.74 30 173696 100862 90353859
Sputum culture positive 107.51 9.74 62 173664 2191 90452530
Feeling of despair 101.65 9.74 68 173658 3136 90451585
Rhabdomyolysis 101.28 9.74 270 173456 50986 90403735
C-reactive protein increased 99.13 9.74 121 173605 181268 90273453
Accidental death 96.77 9.74 56 173670 1992 90452729
Febrile neutropenia 96.01 9.74 97 173629 158252 90296469
Hallucination, auditory 95.93 9.74 135 173591 15840 90438881
Therapeutic product effect incomplete 94.17 9.74 141 173585 193755 90260966
Knee arthroplasty 93.93 9.74 22 173704 83160 90371561
Dislocation of vertebra 93.59 9.74 3 173723 55965 90398756
Autoimmune disorder 93.47 9.74 17 173709 76727 90377994
Lethargy 92.54 9.74 299 173427 62840 90391881
Wheezing 90.74 9.74 201 173525 237879 90216842
Hip arthroplasty 90.44 9.74 18 173708 76190 90378531
Osteoarthritis 89.67 9.74 148 173578 195582 90259139
Oedema 89.41 9.74 154 173572 200141 90254580
Live birth 89.17 9.74 21 173705 79086 90375635
Respiratory acidosis 88.84 9.74 93 173633 8026 90446695
Fatigue 88.79 9.74 1619 172107 1152404 89302317
Adjustment disorder with depressed mood 88.42 9.74 5 173721 56748 90397973
Bone erosion 88.10 9.74 3 173723 53018 90401703
Dependence 87.76 9.74 53 173673 2042 90452679
Delusion 87.66 9.74 120 173606 13720 90441001
Agoraphobia 87.55 9.74 35 173691 533 90454188
Depression 86.08 9.74 918 172808 299683 90155038
Lower limb fracture 85.70 9.74 28 173698 84985 90369736
Tearfulness 85.60 9.74 72 173654 4708 90450013
Cardiac murmur 85.35 9.74 137 173589 18057 90436664
H1N1 influenza 84.59 9.74 51 173675 1959 90452762
Sarcoidosis 83.96 9.74 103 173623 10570 90444151
Psychomotor retardation 83.43 9.74 71 173655 4718 90450003
Bronchial secretion retention 83.00 9.74 63 173663 3552 90451169
Victim of crime 82.38 9.74 38 173688 834 90453887
Depressed mood 82.07 9.74 247 173479 49975 90404746
Liver function test increased 82.00 9.74 30 173696 84825 90369896
Asthma 81.61 9.74 218 173508 241942 90212779
Mental disorder 81.59 9.74 187 173539 32131 90422590
Restless legs syndrome 81.52 9.74 151 173575 22319 90432402
Mobility decreased 81.30 9.74 230 173496 250504 90204217
Sciatica 80.69 9.74 47 173679 101335 90353386
Off label use 79.92 9.74 1562 172164 1100690 89354031
Injury 79.90 9.74 161 173565 197188 90257533
Anger 79.52 9.74 114 173612 13606 90441115
Vision blurred 79.15 9.74 419 173307 109874 90344847
Adverse event 78.18 9.74 66 173660 117352 90337369
Multiple sclerosis relapse 77.83 9.74 249 173477 52056 90402665
Unresponsive to stimuli 77.53 9.74 203 173523 37918 90416803
Akathisia 77.18 9.74 101 173625 11058 90443663
Musculoskeletal stiffness 76.91 9.74 300 173426 296232 90158489
Hepatotoxicity 76.36 9.74 227 173499 45615 90409106
Thrombocytopenia 75.67 9.74 181 173545 208544 90246177
Feeling of body temperature change 75.24 9.74 72 173654 5577 90449144
Blood bilirubin increased 75.03 9.74 218 173508 43252 90411469
Lung disorder 74.72 9.74 107 173619 149776 90304945
Nasal polyps 74.51 9.74 98 173628 10782 90443939
Urinary incontinence 74.32 9.74 198 173528 37368 90417353
Drug withdrawal syndrome neonatal 73.05 9.74 49 173677 2270 90452451
Onychomadesis 71.82 9.74 4 173722 45994 90408727
Alcohol poisoning 71.52 9.74 45 173681 1867 90452854
Lupus-like syndrome 71.17 9.74 6 173720 48840 90405881
Cyanosis 70.91 9.74 131 173595 19324 90435397
X-ray abnormal 70.77 9.74 4 173722 45420 90409301
Amylase increased 70.31 9.74 77 173649 6995 90447726
Nail disorder 69.99 9.74 14 173712 59053 90395668
Victim of chemical submission 69.18 9.74 32 173694 707 90454014
Toxic encephalopathy 68.51 9.74 84 173642 8615 90446106
Red blood cell sedimentation rate increased 67.58 9.74 37 173689 82558 90372163
Cognitive disorder 67.53 9.74 288 173438 69119 90385602
Liver disorder 67.19 9.74 80 173646 121189 90333532
Anaemia 66.97 9.74 399 173327 352403 90102318
Multiple sclerosis 66.89 9.74 158 173568 27682 90427039
Drug abuser 66.49 9.74 49 173677 2641 90452080
Malignant neoplasm progression 66.46 9.74 64 173662 106806 90347915
Taste disorder 66.16 9.74 18 173708 61528 90393193
Catatonia 65.60 9.74 69 173657 5987 90448734
Victim of sexual abuse 64.77 9.74 30 173696 665 90454056
Sinus tachycardia 64.41 9.74 158 173568 28355 90426366
Night sweats 64.11 9.74 92 173634 128674 90326047
Psychomotor skills impaired 63.63 9.74 49 173677 2823 90451898
Visceral congestion 63.49 9.74 25 173701 365 90454356
Gait inability 63.18 9.74 115 173611 146341 90308380
Self-injurious ideation 63.11 9.74 51 173675 3152 90451569
Incontinence 62.79 9.74 101 173625 13334 90441387
Swollen tongue 62.31 9.74 212 173514 45744 90408977
Parkinsonism 62.03 9.74 103 173623 13962 90440759
Hepatic cirrhosis 61.73 9.74 22 173704 63231 90391490
Musculoskeletal pain 61.67 9.74 149 173577 171102 90283619
Paranoia 61.65 9.74 98 173628 12810 90441911
Disease progression 60.66 9.74 131 173595 156484 90298237
Colitis ulcerative 60.48 9.74 20 173706 60246 90394475
Prescribed overdose 60.08 9.74 59 173667 97566 90357155
Sedation complication 59.14 9.74 112 173614 16832 90437889
Pleurothotonus 59.11 9.74 35 173691 1300 90453421
Crying 58.88 9.74 143 173583 25502 90429219
Rhinitis allergic 58.65 9.74 111 173615 16674 90438047
Developmental delay 58.60 9.74 38 173688 1662 90453059
Coeliac disease 58.58 9.74 8 173718 44602 90410119
Death 58.47 9.74 1213 172513 455338 89999383
Maternal exposure during pregnancy 58.36 9.74 427 173299 359636 90095085
Behaviour disorder 57.84 9.74 57 173669 4578 90450143
Paralysis 57.39 9.74 89 173637 11389 90443332
Frequent bowel movements 56.95 9.74 19 173707 56916 90397805
Snoring 56.59 9.74 59 173667 5067 90449654
Cough 55.82 9.74 446 173280 368516 90086205
Troponin increased 55.57 9.74 95 173631 13186 90441535
Drug detoxification 55.21 9.74 22 173704 332 90454389
Myelosuppression 55.17 9.74 17 173709 53574 90401147
Muscle disorder 55.07 9.74 60 173666 5419 90449302
Psychogenic seizure 55.03 9.74 39 173687 1977 90452744
Diabetes insipidus 54.69 9.74 47 173679 3165 90451556
Exostosis 54.44 9.74 17 173709 53117 90401604
Bradycardia 54.42 9.74 310 173416 83537 90371184
Sleep disorder due to a general medical condition 54.29 9.74 10 173716 44728 90409993
Drug screen positive 54.09 9.74 50 173676 3707 90451014
Fall 54.03 9.74 1256 172470 480554 89974167
Pyrexia 53.96 9.74 916 172810 659569 89795152
Loss of personal independence in daily activities 53.41 9.74 113 173613 135992 90318729
Autonomic dysreflexia 53.37 9.74 22 173704 364 90454357
Hallucination, visual 53.27 9.74 129 173597 22963 90431758
Dyspepsia 52.95 9.74 198 173528 197962 90256759
Aspiration 52.64 9.74 102 173624 15591 90439130
Drug level increased 52.58 9.74 144 173582 27618 90427103
Hyperprolactinaemia 52.02 9.74 58 173668 5375 90449346
Obesity 51.91 9.74 76 173650 105431 90349290
Cryopyrin associated periodic syndrome 51.32 9.74 24 173702 544 90454177
Stiff person syndrome 51.32 9.74 23 173703 471 90454250
Bladder dilatation 51.30 9.74 29 173697 986 90453735
Blepharospasm 51.25 9.74 21 173705 55424 90399297
Injection site reaction 50.74 9.74 61 173665 92019 90362702
Conversion disorder 50.60 9.74 38 173688 2108 90452613
COVID-19 50.31 9.74 161 173565 168682 90286039
Drowning 50.23 9.74 23 173703 496 90454225
Psoriasis 49.76 9.74 133 173593 147621 90307100
Menstrual disorder 49.52 9.74 60 173666 6078 90448643
Feeling abnormal 49.35 9.74 514 173212 166721 90288000
Upper respiratory tract infection 49.13 9.74 108 173618 128210 90326511
Immobilisation prolonged 49.13 9.74 16 173710 129 90454592
Victim of child abuse 48.55 9.74 10 173716 5 90454716
Sudden death 48.26 9.74 80 173646 10829 90443892
Feeling jittery 48.06 9.74 97 173629 15274 90439447
Renal ischaemia 47.69 9.74 24 173702 642 90454079
Dyspnoea 47.50 9.74 1306 172420 879649 89575072
Parosmia 47.37 9.74 63 173663 7006 90447715
PCO2 increased 46.86 9.74 30 173696 1283 90453438
Physical assault 46.64 9.74 26 173700 860 90453861
Vertigo 46.55 9.74 260 173466 69551 90385170
Hypertension 46.49 9.74 608 173118 456924 89997797
Drug-induced liver injury 46.48 9.74 63 173663 90255 90364466
Hypersomnia 46.20 9.74 117 173609 21414 90433307
Drug hypersensitivity 46.04 9.74 619 173107 462990 89991731
Laryngitis 45.67 9.74 20 173706 50733 90403988
Patient uncooperative 45.52 9.74 18 173708 266 90454455
Electrocardiogram QRS complex prolonged 45.47 9.74 63 173663 7285 90447436
Abdominal pain upper 45.43 9.74 413 173313 332261 90122460
Finger deformity 45.40 9.74 5 173721 32892 90421829
Myocardial fibrosis 45.23 9.74 26 173700 913 90453808
Electroencephalogram abnormal 44.96 9.74 47 173679 4049 90450672
Obstructive airways disorder 44.90 9.74 130 173596 25739 90428982
Ductus arteriosus premature closure 44.88 9.74 20 173706 404 90454317
Injection site pain 44.83 9.74 176 173550 173523 90281198
Fluid retention 44.77 9.74 62 173664 88029 90366692
Treatment noncompliance 44.55 9.74 207 173519 51520 90403201
Housebound 44.42 9.74 17 173709 229 90454492
Osteoporosis 44.18 9.74 73 173653 96458 90358263
Mucosal inflammation 44.05 9.74 28 173698 57597 90397124
Creatinine renal clearance increased 44.04 9.74 42 173684 3239 90451482
Rhesus incompatibility 43.98 9.74 14 173712 104 90454617
Postictal psychosis 43.98 9.74 14 173712 104 90454617
Mutism 43.22 9.74 32 173694 1737 90452984
Myoclonus 43.06 9.74 106 173620 19062 90435659
Foot deformity 42.90 9.74 31 173695 59620 90395101
Blood pH decreased 42.68 9.74 37 173689 2521 90452200
Drug diversion 42.61 9.74 26 173700 1021 90453700
Abnormal dreams 42.54 9.74 77 173649 11180 90443541
Pancreatic fibrosis 42.27 9.74 13 173713 85 90454636
Stupor 41.67 9.74 52 173674 5430 90449291
Tardive dyskinesia 41.61 9.74 75 173651 10855 90443866
Sinus bradycardia 41.59 9.74 97 173629 16855 90437866
Foetal exposure during pregnancy 41.55 9.74 178 173548 42797 90411924
Emotional distress 41.12 9.74 159 173567 36503 90418218
PO2 increased 41.11 9.74 24 173702 868 90453853
Hepatic necrosis 41.04 9.74 56 173670 6382 90448339
Hypertonia 40.95 9.74 50 173676 5105 90449616
Therapeutic product ineffective 40.45 9.74 35 173691 2379 90452342
Right ventricular hypertrophy 40.37 9.74 23 173703 794 90453927
Adverse drug reaction 40.09 9.74 104 173622 116597 90338124
Weight increased 40.05 9.74 562 173164 417365 90037356
Hypoxic-ischaemic encephalopathy 39.91 9.74 47 173679 4621 90450100
Contusion 39.68 9.74 300 173426 250916 90203805
Aphasia 39.61 9.74 175 173551 42637 90412084
Hyperthermia 39.45 9.74 71 173655 10264 90444457
Lung neoplasm malignant 39.29 9.74 119 173607 24154 90430567
Mental impairment 39.20 9.74 94 173632 16626 90438095
Incoherent 39.10 9.74 48 173678 4929 90449792
Eosinophil count increased 39.06 9.74 81 173645 13000 90441721
Social avoidant behaviour 38.97 9.74 40 173686 3373 90451348
Nystagmus 38.91 9.74 58 173668 7169 90447552
Logorrhoea 38.70 9.74 36 173690 2691 90452030
Device expulsion 38.58 9.74 15 173711 40871 90413850
Cortisol increased 38.50 9.74 19 173707 487 90454234
Generalised anxiety disorder 38.47 9.74 36 173690 2711 90452010
Hypoventilation 38.29 9.74 49 173677 5247 90449474
Onychomycosis 38.21 9.74 12 173714 37364 90417357
Oromandibular dystonia 38.17 9.74 20 173706 583 90454138
Somatic delusion 37.83 9.74 20 173706 594 90454127
Faecaloma 37.71 9.74 70 173656 10361 90444360
Choking 37.69 9.74 76 173650 11957 90442764
Joint stiffness 37.62 9.74 57 173669 77985 90376736
Hypotonia neonatal 37.50 9.74 27 173699 1403 90453318
Euphoric mood 37.47 9.74 49 173677 5360 90449361
Suicidal behaviour 37.41 9.74 36 173690 2808 90451913
Alcohol use 37.40 9.74 29 173697 1688 90453033
Antipsychotic drug level increased 37.32 9.74 41 173685 3738 90450983
Blood calcium decreased 37.26 9.74 135 173591 30047 90424674
Walking aid user 37.02 9.74 11 173715 35495 90419226
Cytomegalovirus infection 36.82 9.74 4 173722 26598 90428123
Sensory disturbance 36.51 9.74 87 173639 15326 90439395
Dysphagia 36.44 9.74 352 173374 111926 90342795
Fear 36.37 9.74 91 173635 16531 90438190
Panic reaction 36.26 9.74 45 173681 4672 90450049
Neurosis 36.25 9.74 17 173709 388 90454333
Antipsychotic drug level decreased 35.93 9.74 17 173709 396 90454325
Neutropenia 35.79 9.74 268 173458 224636 90230085
Therapeutic response decreased 35.62 9.74 74 173652 89655 90365066
Amimia 35.50 9.74 11 173715 74 90454647
Hypokinesia 35.47 9.74 87 173639 15610 90439111
Blood sodium decreased 35.36 9.74 125 173601 27488 90427233
Autonomic nervous system imbalance 35.06 9.74 38 173688 3412 90451309
Somnambulism 35.00 9.74 51 173675 6177 90448544
Bezoar 34.82 9.74 34 173692 2700 90452021
Bronchiectasis 34.77 9.74 108 173618 22222 90432499
Alcohol interaction 34.71 9.74 28 173698 1726 90452995
Multiple drug therapy 34.56 9.74 54 173672 6955 90447766
Bradykinesia 34.45 9.74 53 173673 6735 90447986
Thinking abnormal 34.28 9.74 72 173654 11660 90443061
Interstitial lung disease 33.84 9.74 59 173667 76346 90378375
Apathy 33.72 9.74 69 173657 10971 90443750
Bone marrow failure 33.57 9.74 10 173716 32211 90422510
Anticonvulsant drug level above therapeutic 33.56 9.74 18 173708 551 90454170
Neoplasm progression 33.48 9.74 22 173704 44464 90410257
Somatic symptom disorder 33.40 9.74 37 173689 3404 90451317
Haemodynamic instability 33.09 9.74 71 173655 11668 90443053
Obsessive-compulsive disorder 33.08 9.74 42 173684 4462 90450259
Immunodeficiency 33.06 9.74 21 173705 43213 90411508
Blood pressure systolic increased 32.84 9.74 38 173688 58307 90396414
Constipation 32.63 9.74 735 172991 279660 90175061
Circulatory collapse 32.12 9.74 113 173613 24791 90429930
Creatinine renal clearance decreased 31.86 9.74 94 173632 18805 90435916
Hypoaesthesia oral 31.64 9.74 83 173643 15517 90439204
Product use in unapproved indication 31.54 9.74 454 173272 335782 90118939
Urine osmolarity increased 31.33 9.74 11 173715 114 90454607
Right ventricular dilatation 31.27 9.74 26 173700 1673 90453048
Feeling drunk 31.26 9.74 42 173684 4716 90450005
Psychiatric symptom 31.22 9.74 52 173674 7066 90447655
Blood potassium increased 31.06 9.74 99 173627 20650 90434071
Cholestasis 31.06 9.74 145 173581 36154 90418567
Toxic epidermal necrolysis 30.88 9.74 134 173592 32394 90422327
Renal function test abnormal 30.83 9.74 52 173674 7139 90447582
Pulmonary mass 30.82 9.74 123 173603 28649 90426072
Respiratory rate decreased 30.62 9.74 38 173688 3945 90450776
Prescribed underdose 30.51 9.74 61 173665 74958 90379763
Arteriosclerosis coronary artery 30.50 9.74 61 173665 9542 90445179
Nasal congestion 30.47 9.74 72 173654 83342 90371379
Encephalopathy 30.32 9.74 172 173554 46272 90408449
Emotional poverty 30.23 9.74 15 173711 389 90454332
Strabismus 30.15 9.74 30 173696 2438 90452283
Gastrointestinal motility disorder 30.13 9.74 47 173679 6044 90448677
Calcium deficiency 30.10 9.74 23 173703 1310 90453411
Chronic obstructive pulmonary disease 29.92 9.74 243 173483 73586 90381135
Prescription drug used without a prescription 29.89 9.74 34 173692 3221 90451500
Rectal haemorrhage 29.77 9.74 72 173654 82672 90372049
Mucosal erosion 29.41 9.74 26 173700 1819 90452902
Panic disorder 29.39 9.74 33 173693 3082 90451639
Urine sodium increased 29.17 9.74 10 173716 96 90454625
Multiple allergies 29.12 9.74 79 173647 15067 90439654
Persistent depressive disorder 29.07 9.74 22 173704 1235 90453486
Gastrointestinal haemorrhage 29.06 9.74 83 173643 90165 90364556
Premature labour 29.03 9.74 73 173653 13303 90441418
Scan abnormal 28.99 9.74 17 173709 620 90454101
Apnoea 28.94 9.74 59 173667 9355 90445366
Back injury 28.89 9.74 28 173698 46594 90408127
Pain in extremity 28.76 9.74 651 173075 449878 90004843
Major depression 28.64 9.74 61 173665 9974 90444747
Electrocardiogram QRS complex shortened 28.52 9.74 16 173710 536 90454185
Head injury 28.49 9.74 127 173599 31061 90423660
Blood prolactin increased 28.45 9.74 35 173691 3602 90451119
Pyramidal tract syndrome 28.33 9.74 16 173710 543 90454178
Food allergy 28.25 9.74 7 173719 25471 90429250
Posturing 28.14 9.74 16 173710 550 90454171
Unmasking of previously unidentified disease 28.03 9.74 23 173703 1453 90453268
Alcoholism 27.96 9.74 25 173701 1775 90452946
Oral discomfort 27.95 9.74 62 173664 10421 90444300
Respiratory failure 27.73 9.74 348 173378 118070 90336651
Wrong rate 27.73 9.74 11 173715 164 90454557
Musculoskeletal toxicity 27.63 9.74 16 173710 570 90454151
Premature baby 27.50 9.74 108 173618 24969 90429752
Colitis 27.49 9.74 58 173668 69884 90384837
Pancytopenia 27.25 9.74 128 173598 120135 90334586
Blood osmolarity decreased 27.22 9.74 19 173707 940 90453781
Upper-airway cough syndrome 27.18 9.74 77 173649 15058 90439663
Tinnitus 27.07 9.74 158 173568 42944 90411777
Flashback 27.04 9.74 13 173713 314 90454407
Chest wall mass 26.88 9.74 16 173710 600 90454121
Rhesus antigen positive 26.88 9.74 10 173716 124 90454597
Sputum culture 26.78 9.74 13 173713 321 90454400
Pallor 26.73 9.74 133 173593 34032 90420689
Choroidal coloboma 26.67 9.74 7 173719 23 90454698
Product dose omission issue 26.60 9.74 396 173330 291291 90163430
Marchiafava-Bignami disease 26.49 9.74 6 173720 8 90454713
Intellectual disability 26.45 9.74 21 173705 1265 90453456
Movement disorder 26.38 9.74 118 173608 28901 90425820
Abdominal pain 26.34 9.74 568 173158 395153 90059568
Haematochezia 26.07 9.74 61 173665 70852 90383869
Poor sucking reflex 26.03 9.74 14 173712 431 90454290
Fear of disease 25.95 9.74 22 173704 1454 90453267
Pulmonary congestion 25.77 9.74 89 173637 19344 90435377
Haemoglobin decreased 25.75 9.74 193 173533 161763 90292958
Therapy non-responder 25.69 9.74 155 173571 136549 90318172
Macular degeneration 25.69 9.74 21 173705 37949 90416772
Torticollis 25.69 9.74 28 173698 2530 90452191
Illness anxiety disorder 25.65 9.74 10 173716 142 90454579
Blood pressure fluctuation 25.54 9.74 38 173688 52375 90402346
Negativism 25.51 9.74 14 173712 449 90454272
Genital erosion 25.51 9.74 14 173712 449 90454272
Bundle branch block right 25.49 9.74 41 173685 5412 90449309
Platelet count decreased 25.37 9.74 156 173570 136813 90317908
Terminal dribbling 25.33 9.74 6 173720 11 90454710
Theft 25.32 9.74 9 173717 97 90454624
Clonus 25.21 9.74 42 173684 5708 90449013
Ventricular dyskinesia 25.15 9.74 10 173716 150 90454571
Basal ganglion degeneration 25.13 9.74 13 173713 369 90454352
Spleen congestion 25.00 9.74 9 173717 101 90454620
Psychotic symptom 24.96 9.74 26 173700 2230 90452491
Suspected suicide 24.85 9.74 56 173670 9512 90445209
Herpes zoster 24.34 9.74 96 173630 94548 90360173
Pulmonary embolism 24.34 9.74 369 173357 130451 90324270
Condition aggravated 24.29 9.74 915 172811 594630 89860091
Petit mal epilepsy 24.17 9.74 38 173688 4920 90449801
Affective disorder 24.15 9.74 49 173677 7744 90446977
Tissue infiltration 24.14 9.74 17 173709 853 90453868
Sluggishness 24.11 9.74 42 173684 5917 90448804
Otospondylomegaepiphyseal dysplasia 24.09 9.74 9 173717 113 90454608
Intestinal pseudo-obstruction 23.94 9.74 19 173707 1144 90453577
Oropharyngeal pain 23.59 9.74 127 173599 115060 90339661
Negative symptoms in schizophrenia 23.46 9.74 9 173717 122 90454599
Alpha 1 microglobulin increased 23.41 9.74 7 173719 41 90454680
Sudden cardiac death 23.41 9.74 25 173701 2207 90452514
Borderline personality disorder 23.36 9.74 18 173708 1038 90453683
Heart rate increased 23.19 9.74 324 173402 112578 90342143
Dry mouth 23.19 9.74 233 173493 183826 90270895
Disinhibition 23.18 9.74 18 173708 1050 90453671
Multiple-drug resistance 23.04 9.74 48 173678 7728 90446993
Galactorrhoea 23.04 9.74 36 173690 4636 90450085
Potentiating drug interaction 23.03 9.74 40 173686 5622 90449099
Dyspnoea exertional 22.90 9.74 67 173659 72221 90382500
Ventricular tachycardia 22.86 9.74 101 173625 24607 90430114
Neonatal complications of substance abuse 22.84 9.74 5 173721 5 90454716
Stevens-Johnson syndrome 22.73 9.74 114 173612 29262 90425459
Cholinergic syndrome 22.63 9.74 15 173711 681 90454040
Tooth hypoplasia 22.61 9.74 8 173718 85 90454636
Impaired reasoning 22.58 9.74 9 173717 136 90454585
Hepatic steatosis 22.28 9.74 134 173592 36811 90417910
Enterochromaffin cell hyperplasia 22.11 9.74 7 173719 51 90454670
Seizure cluster 22.09 9.74 12 173714 377 90454344
Blood albumin abnormal 22.02 9.74 18 173708 1131 90453590
Inadequate analgesia 22.01 9.74 29 173697 3195 90451526
Base excess 21.99 9.74 7 173719 52 90454669
Basal cell carcinoma 21.93 9.74 19 173707 33370 90421351
Anxiety disorder 21.64 9.74 36 173690 4886 90449835
Distal intestinal obstruction syndrome 21.31 9.74 13 173713 510 90454211
Suspected counterfeit product 21.25 9.74 13 173713 513 90454208
Blood bicarbonate decreased 21.21 9.74 28 173698 3091 90451630
Carcinoid tumour of the stomach 21.19 9.74 9 173717 161 90454560
Impulsive behaviour 21.08 9.74 21 173705 1709 90453012
Joint dislocation 21.07 9.74 33 173693 44549 90410172
Brief psychotic disorder with marked stressors 21.02 9.74 7 173719 61 90454660
Gallbladder cholesterolosis 20.95 9.74 15 173711 773 90453948
Hyperreflexia 20.80 9.74 42 173684 6615 90448106
Pustular psoriasis 20.76 9.74 5 173721 18551 90436170
Slow response to stimuli 20.65 9.74 17 173709 1079 90453642
Illogical thinking 20.62 9.74 7 173719 65 90454656
Distractibility 20.52 9.74 13 173713 546 90454175
Pleural effusion 20.51 9.74 128 173598 111863 90342858
Primitive reflex test positive 20.50 9.74 5 173721 11 90454710
Tension 20.47 9.74 30 173696 3652 90451069
Ear infection 20.45 9.74 67 173659 69708 90385013
Polyarthritis 20.42 9.74 5 173721 18345 90436376
Nail avulsion 20.38 9.74 11 173715 341 90454380
Abdominal tenderness 20.35 9.74 51 173675 9273 90445448
Nervousness 20.21 9.74 123 173603 33933 90420788
Eye haematoma 20.18 9.74 8 173718 119 90454602
Injection site pruritus 20.04 9.74 46 173680 53788 90400933
Sensory loss 19.95 9.74 78 173648 17997 90436724
Myocarditis septic 19.95 9.74 6 173720 36 90454685
Oropharyngeal oedema 19.92 9.74 11 173715 357 90454364
Substance abuser 19.92 9.74 9 173717 188 90454533
Cardiac death 19.92 9.74 13 173713 575 90454146
Hypotensive crisis 19.90 9.74 7 173719 73 90454648
Electrocardiogram ST segment elevation 19.88 9.74 31 173695 3985 90450736
Syndactyly 19.78 9.74 13 173713 582 90454139
Infusion site reaction 19.67 9.74 6 173720 19033 90435688
Benzodiazepine drug level increased 19.66 9.74 9 173717 194 90454527
Hostility 19.62 9.74 23 173703 2250 90452471
Radial nerve palsy 19.46 9.74 13 173713 598 90454123
Proctitis 19.42 9.74 3 173723 15256 90439465
Adverse reaction 19.41 9.74 17 173709 29695 90425026
Hypergastrinaemia 19.37 9.74 8 173718 133 90454588
Cerebellar syndrome 19.33 9.74 30 173696 3842 90450879
Blood alkaline phosphatase abnormal 19.30 9.74 18 173708 1350 90453371
Newborn persistent pulmonary hypertension 19.20 9.74 10 173716 288 90454433
Myelodysplastic syndrome 19.18 9.74 8 173718 20895 90433826
Pupil fixed 19.15 9.74 22 173704 2106 90452615
Quadriparesis 19.09 9.74 24 173702 2525 90452196
Eosinophil count decreased 19.07 9.74 27 173699 3185 90451536
Cerebrospinal fluid leakage 19.05 9.74 19 173707 1548 90453173
Respiratory alkalosis 19.03 9.74 28 173698 3420 90451301
Hyperinsulinaemia 19.00 9.74 8 173718 140 90454581
Injection site erythema 18.87 9.74 111 173615 98391 90356330
Diastolic hypotension 18.80 9.74 7 173719 87 90454634
Paradoxical drug reaction 18.76 9.74 37 173689 5729 90448992
Hyperacusis 18.76 9.74 25 173701 2786 90451935
Decreased appetite 18.74 9.74 564 173162 375976 90078745
Pneumocystis jirovecii pneumonia 18.70 9.74 9 173717 21607 90433114
Brain injury 18.68 9.74 44 173682 7694 90447027
Illusion 18.54 9.74 17 173709 1247 90453474
Depressive symptom 18.52 9.74 35 173691 5250 90449471
Blood creatinine increased 18.50 9.74 116 173610 101270 90353451
Central pain syndrome 18.38 9.74 13 173713 657 90454064
Acidosis 18.37 9.74 60 173666 12676 90442045
Bronchitis 18.27 9.74 196 173530 152731 90301990
Performance fear 18.27 9.74 4 173722 4 90454717
Thymus disorder 18.24 9.74 10 173716 320 90454401
Blood lactate dehydrogenase increased 18.24 9.74 98 173628 25834 90428887
Atrial fibrillation 18.16 9.74 166 173560 133445 90321276
Hypoaesthesia 18.11 9.74 461 173265 313749 90140972
Muscle twitching 18.08 9.74 93 173633 24109 90430612
Porphyria acute 17.97 9.74 6 173720 17969 90436752
Cor pulmonale acute 17.93 9.74 11 173715 436 90454285
Hepatic cytolysis 17.93 9.74 111 173615 30805 90423916
Hyperaesthesia 17.82 9.74 53 173673 10649 90444072
Areflexia 17.81 9.74 28 173698 3625 90451096
Female genital tract fistula 17.80 9.74 6 173720 17862 90436859
Thyroxine free decreased 17.77 9.74 14 173712 834 90453887
Rash pruritic 17.76 9.74 89 173637 82125 90372596
Craniosynostosis 17.71 9.74 8 173718 167 90454554
Skin ulcer 17.68 9.74 44 173682 50031 90404690
Orthostatic hypotension 17.67 9.74 139 173587 41688 90413033
Persecutory delusion 17.64 9.74 26 173700 3182 90451539
Chronic sinusitis 17.60 9.74 12 173714 23790 90430931
Foaming at mouth 17.59 9.74 17 173709 1333 90453388
Anaesthesia 17.56 9.74 11 173715 453 90454268
Lupus hepatitis 17.55 9.74 5 173721 24 90454697
Drug reaction with eosinophilia and systemic symptoms 17.46 9.74 141 173585 42617 90412104
Thyroid adenoma 17.45 9.74 8 173718 173 90454548
Myofascial pain syndrome 17.45 9.74 25 173701 2982 90451739
Vestibular disorder 17.41 9.74 18 173708 1531 90453190
Drug level above therapeutic 17.38 9.74 36 173690 5773 90448948
Arteriosclerosis 17.37 9.74 53 173673 10800 90443921
Adrenal insufficiency 17.37 9.74 19 173707 29902 90424819
Dyspraxia 17.35 9.74 9 173717 257 90454464
Muscle tightness 17.35 9.74 61 173665 13378 90441343
Tongue discolouration 17.35 9.74 27 173699 3466 90451255
Toxicologic test abnormal 17.34 9.74 13 173713 719 90454002
Congenital central nervous system anomaly 17.34 9.74 11 173715 463 90454258
Macroglossia 17.33 9.74 14 173712 865 90453856
Blood immunoglobulin M decreased 17.30 9.74 17 173709 1360 90453361
Mitral valve disease 17.28 9.74 23 173703 2559 90452162
Diplopia 17.22 9.74 104 173622 28610 90426111
Partial seizures 17.22 9.74 41 173685 7219 90447502
Facial nerve disorder 17.20 9.74 12 173714 593 90454128
Drug-device interaction 17.20 9.74 7 173719 112 90454609
Left ventricular hypertrophy 17.13 9.74 37 173689 6107 90448614
Maternal exposure timing unspecified 17.08 9.74 11 173715 22472 90432249
Hyperventilation 17.06 9.74 39 173687 6689 90448032
Gait deviation 17.02 9.74 6 173720 63 90454658
Delirium 17.02 9.74 288 173438 104071 90350650
Trismus 16.99 9.74 32 173694 4789 90449932
Limb injury 16.96 9.74 111 173615 31397 90423324
Intestinal infarction 16.93 9.74 15 173711 1052 90453669
Productive cough 16.89 9.74 83 173643 76980 90377741
Sputum discoloured 16.87 9.74 9 173717 20382 90434339
Hypersexuality 16.83 9.74 12 173714 614 90454107
Hepatitis 16.79 9.74 74 173652 70665 90384056
Respiratory distress 16.77 9.74 130 173596 38816 90415905
Drug dose titration not performed 16.73 9.74 13 173713 759 90453962
Hypervolaemia 16.70 9.74 23 173703 32734 90421987
Myoclonic epilepsy 16.67 9.74 18 173708 1609 90453112
Circulating anticoagulant positive 16.62 9.74 5 173721 30 90454691
Lack of spontaneous speech 16.61 9.74 8 173718 194 90454527
Alcohol abuse 16.61 9.74 20 173706 2013 90452708
Chest pain 16.59 9.74 476 173250 319169 90135552
Urinary hesitation 16.58 9.74 22 173704 2441 90452280
Nodule 16.56 9.74 16 173710 26670 90428051
Poor quality sleep 16.48 9.74 92 173634 24601 90430120
Blood sodium increased 16.37 9.74 25 173701 3157 90451564
Accidental poisoning 16.25 9.74 14 173712 946 90453775
Sensation of foreign body 16.25 9.74 37 173689 6329 90448392
Thrombotic microangiopathy 16.19 9.74 5 173721 15738 90438983
Blood bilirubin decreased 16.19 9.74 14 173712 951 90453770
Nervous system disorder 16.15 9.74 83 173643 21510 90433211
Basophil count decreased 16.11 9.74 9 173717 299 90454422
Morganella infection 16.09 9.74 13 173713 803 90453918
Ulcer haemorrhage 16.08 9.74 16 173710 26305 90428416
Waxy flexibility 16.05 9.74 7 173719 134 90454587
Ventricular compliance decreased 15.97 9.74 5 173721 35 90454686
Left ventricular dysfunction 15.94 9.74 63 173663 14606 90440115
Neurological decompensation 15.93 9.74 26 173700 3475 90451246
Screaming 15.92 9.74 27 173699 3723 90450998
Formication 15.90 9.74 31 173695 4760 90449961
Dysmorphism 15.86 9.74 22 173704 2546 90452175
Congestive cardiomyopathy 15.82 9.74 40 173686 7314 90447407
Lactate pyruvate ratio increased 15.80 9.74 6 173720 79 90454642
Caesarean section 15.74 9.74 74 173652 18503 90436218
Device difficult to use 15.62 9.74 7 173719 17518 90437203
Phyllodes tumour 15.60 9.74 6 173720 82 90454639
Acute psychosis 15.58 9.74 24 173702 3054 90451667
Spondylitis 15.52 9.74 4 173722 14174 90440547
Clonic convulsion 15.50 9.74 13 173713 847 90453874
Inappropriate affect 15.46 9.74 14 173712 1011 90453710
Mental status changes 15.45 9.74 142 173584 44537 90410184
Bipolar disorder 15.44 9.74 45 173681 8940 90445781
Defect conduction intraventricular 15.43 9.74 8 173718 228 90454493
Bruxism 15.42 9.74 29 173697 4334 90450387
Blood calcium abnormal 15.42 9.74 19 173707 1958 90452763
Congenital hand malformation 15.40 9.74 9 173717 326 90454395
Apgar score low 15.39 9.74 15 173711 1188 90453533
Brain oedema 15.28 9.74 70 173656 17315 90437406
Injection site swelling 15.19 9.74 61 173665 59778 90394943
Ear pain 15.18 9.74 58 173668 57644 90397077
Needle track marks 15.05 9.74 4 173722 14 90454707
Perforation bile duct 15.05 9.74 4 173722 14 90454707
Atrioventricular septal defect 15.01 9.74 9 173717 342 90454379
Hepatocellular injury 14.97 9.74 101 173625 28857 90425864
Gastric lavage 14.87 9.74 5 173721 45 90454676
Morbid thoughts 14.84 9.74 12 173714 742 90453979
Neutrophil count increased 14.82 9.74 75 173651 19315 90435406
Myocarditis 14.77 9.74 59 173667 13747 90440974
Self-medication 14.76 9.74 24 173702 3196 90451525
Uveitis 14.73 9.74 6 173720 15897 90438824
Eye movement disorder 14.70 9.74 35 173691 6163 90448558
Erythema 14.68 9.74 331 173395 228915 90225806
Abscess sterile 14.58 9.74 5 173721 48 90454673
Neutrophil count decreased 14.57 9.74 79 173647 71453 90383268
Asthenia 14.55 9.74 856 172870 532895 89921826
Disorganised speech 14.52 9.74 18 173708 1867 90452854
Social anxiety disorder 14.46 9.74 11 173715 622 90454099
Drug screen false positive 14.46 9.74 13 173713 930 90453791
Hypercapnic coma 14.34 9.74 8 173718 265 90454456
Premature delivery 14.33 9.74 125 173601 38637 90416084
Cardiomegaly 14.33 9.74 73 173653 18852 90435869
Cardiogenic shock 14.28 9.74 88 173638 24380 90430341
Sinus congestion 14.24 9.74 19 173707 27405 90427316
Intervertebral disc disorder 14.23 9.74 32 173694 5428 90449293
Neurological examination normal 14.23 9.74 5 173721 52 90454669
Respiratory tract congestion 14.22 9.74 19 173707 27391 90427330
Inappropriate schedule of product administration 14.20 9.74 202 173524 149731 90304990
Tonic clonic movements 14.17 9.74 17 173709 1705 90453016
Slow speech 14.16 9.74 18 173708 1915 90452806
Blood citric acid increased 14.14 9.74 5 173721 53 90454668
Injection site warmth 14.10 9.74 8 173718 17507 90437214
Eye pain 14.09 9.74 138 173588 44030 90410691
Decreased interest 14.00 9.74 28 173698 4379 90450342
Dermatitis exfoliative 13.93 9.74 32 173694 5504 90449217
Cardiac arrest neonatal 13.90 9.74 6 173720 112 90454609
Coloboma 13.90 9.74 6 173720 112 90454609
Aspartate aminotransferase decreased 13.88 9.74 13 173713 980 90453741
Camptocormia 13.81 9.74 8 173718 285 90454436
Foetal anticonvulsant syndrome 13.81 9.74 11 173715 666 90454055
Delirium tremens 13.75 9.74 6 173720 115 90454606
Pulmonary arterial hypertension 13.74 9.74 18 173708 26169 90428552
Central nervous system stimulation 13.74 9.74 5 173721 58 90454663
Enuresis 13.73 9.74 24 173702 3390 90451331
Blood albumin increased 13.73 9.74 14 173712 1171 90453550
Monoplegia 13.72 9.74 25 173701 3649 90451072
Frontotemporal dementia 13.71 9.74 9 173717 402 90454319
Exposure to unspecified agent 13.70 9.74 3 173723 3 90454718
Exposure during pregnancy 13.67 9.74 350 173376 238060 90216661
COVID-19 pneumonia 13.66 9.74 9 173717 18168 90436553
Respiratory dyskinesia 13.66 9.74 5 173721 59 90454662
Tongue movement disturbance 13.63 9.74 9 173717 406 90454315
Drop attacks 13.57 9.74 11 173715 683 90454038
Insomnia 13.55 9.74 775 172951 332699 90122022
Blood pressure diastolic decreased 13.51 9.74 19 173707 26807 90427914
Periorbital swelling 13.50 9.74 29 173697 4769 90449952
Anticonvulsant drug level decreased 13.50 9.74 15 173711 1385 90453336
Oculogyric crisis 13.50 9.74 20 173706 2459 90452262
Diabetic retinal oedema 13.49 9.74 9 173717 413 90454308
Hepatitis toxic 13.47 9.74 25 173701 3700 90451021
Porphyria 13.46 9.74 7 173719 201 90454520
Hyporeflexia 13.38 9.74 19 173707 2247 90452474
Moaning 13.34 9.74 13 173713 1030 90453691
Implant site extravasation 13.31 9.74 10 173716 555 90454166
Postmortem blood drug level increased 13.28 9.74 11 173715 704 90454017
Myositis 13.27 9.74 16 173710 24112 90430609
Glomerular filtration rate increased 13.26 9.74 18 173708 2042 90452679
Acute myeloid leukaemia 13.25 9.74 12 173714 20628 90434093
Peritoneal perforation 13.25 9.74 6 173720 126 90454595
Blood alcohol increased 13.25 9.74 10 173716 559 90454162
Multiple lentigines syndrome 13.24 9.74 7 173719 208 90454513
Road traffic accident 13.24 9.74 137 173589 107489 90347232
Cardiac failure 13.21 9.74 140 173586 109356 90345365
Rhinorrhoea 13.21 9.74 107 173619 88209 90366512
Postoperative delirium 13.21 9.74 7 173719 209 90454512
Ascites 13.20 9.74 47 173679 47693 90407028
Educational problem 13.19 9.74 10 173716 563 90454158
Judgement impaired 13.17 9.74 12 173714 873 90453848
Delusion of reference 13.16 9.74 6 173720 128 90454593
Hyperchloraemia 13.14 9.74 12 173714 876 90453845
Prescription form tampering 13.12 9.74 11 173715 716 90454005
Hospitalisation 13.06 9.74 170 173556 127930 90326791
Junctional ectopic tachycardia 13.06 9.74 7 173719 214 90454507
Hemiparesis 13.03 9.74 105 173621 31714 90423007
Palmar-plantar erythrodysaesthesia syndrome 13.00 9.74 21 173705 28002 90426719
Poverty of speech 12.98 9.74 8 173718 320 90454401
Product administration error 12.97 9.74 91 173635 26332 90428389
Poor venous access 12.96 9.74 11 173715 19516 90435205
Blood fibrinogen increased 12.96 9.74 12 173714 892 90453829
Cytokine release syndrome 12.94 9.74 21 173705 27952 90426769
Pregnancy 12.93 9.74 68 173658 61979 90392742
Neonatal disorder 12.90 9.74 10 173716 582 90454139
Choreoathetosis 12.90 9.74 10 173716 582 90454139
Change in seizure presentation 12.90 9.74 10 173716 582 90454139
Victim of homicide 12.89 9.74 5 173721 70 90454651
Cataract 12.89 9.74 83 173643 72009 90382712
Body temperature decreased 12.88 9.74 16 173710 23800 90430921
Transferrin saturation decreased 12.88 9.74 12 173714 899 90453822
Product quality issue 12.86 9.74 94 173632 79231 90375490
Severe myoclonic epilepsy of infancy 12.76 9.74 5 173721 72 90454649
Dysphoria 12.75 9.74 33 173693 6121 90448600
Alcohol withdrawal syndrome 12.73 9.74 12 173714 912 90453809
Polyglandular disorder 12.68 9.74 7 173719 227 90454494
Coordination abnormal 12.59 9.74 77 173649 21279 90433442
Motor developmental delay 12.57 9.74 7 173719 231 90454490
Purpura senile 12.56 9.74 10 173716 605 90454116
Snake bite 12.49 9.74 3 173723 6 90454715
Parkinsonism hyperpyrexia syndrome 12.46 9.74 7 173719 235 90454486
Anticonvulsant drug level increased 12.45 9.74 16 173710 1720 90453001
Cardiotoxicity 12.45 9.74 49 173677 11340 90443381
Tonic convulsion 12.44 9.74 16 173710 1722 90452999
Muscle contractions involuntary 12.32 9.74 21 173705 2907 90451814
Ulcer 12.32 9.74 28 173698 32854 90421867
Injection site bruising 12.25 9.74 55 173671 52252 90402469
Uterine enlargement 12.24 9.74 14 173712 1334 90453387
Oxygen saturation abnormal 12.16 9.74 26 173700 4262 90450459
Wrong patient received product 12.15 9.74 23 173703 3454 90451267
Dry skin 12.15 9.74 109 173617 87964 90366757
Homicidal ideation 12.14 9.74 16 173710 1764 90452957
Confusional state 12.13 9.74 878 172848 385327 90069394
Loss of libido 12.08 9.74 14 173712 1353 90453368
Hepatitis cholestatic 12.05 9.74 40 173686 8521 90446200
Bacteraemia 12.04 9.74 15 173711 22285 90432436
Hepatitis acute 12.03 9.74 47 173679 10840 90443881
Ventricular arrhythmia 12.03 9.74 26 173700 4295 90450426
Electrocardiogram repolarisation abnormality 12.01 9.74 14 173712 1362 90453359
Corrective lens user 11.99 9.74 7 173719 253 90454468
Skin haemorrhage 11.95 9.74 14 173712 21366 90433355
Vascular device infection 11.93 9.74 4 173722 11948 90442773
Skin necrosis 11.93 9.74 9 173717 16932 90437789
Automatic bladder 11.90 9.74 5 173721 87 90454634
Eye irritation 11.88 9.74 30 173696 33948 90420773
Blood immunoglobulin G decreased 11.87 9.74 23 173703 3515 90451206
Labelled drug-food interaction issue 11.80 9.74 4 173722 37 90454684
Fungal infection 11.80 9.74 42 173684 42619 90412102
Neuropathy peripheral 11.78 9.74 188 173538 136782 90317939
Kidney enlargement 11.76 9.74 11 173715 828 90453893
Blood pressure diastolic increased 11.75 9.74 5 173721 12901 90441820
Dysaesthesia 11.74 9.74 29 173697 5226 90449495
Psychotic behaviour 11.73 9.74 10 173716 666 90454055
Epileptic encephalopathy 11.73 9.74 8 173718 381 90454340
Pupillary reflex impaired 11.71 9.74 19 173707 2526 90452195
Hereditary angioedema 11.65 9.74 42 173684 9323 90445398
Body mass index decreased 11.65 9.74 9 173717 521 90454200
Resorption bone increased 11.65 9.74 13 173713 1206 90453515
Muscle atrophy 11.60 9.74 39 173687 8362 90446359
Dysphemia 11.60 9.74 21 173705 3049 90451672
Skin discolouration 11.58 9.74 133 173593 44182 90410539
Inguinal hernia 11.53 9.74 17 173709 2081 90452640
Mood altered 11.52 9.74 64 173662 17080 90437641
Liposuction 11.52 9.74 4 173722 40 90454681
Deafness neurosensory 11.51 9.74 34 173692 6807 90447914
Iris hyperpigmentation 11.43 9.74 4 173722 41 90454680
Cardiopulmonary failure 11.43 9.74 25 173701 4163 90450558
Influenza 11.36 9.74 193 173533 139071 90315650
Arthritis enteropathic 11.33 9.74 8 173718 403 90454318
Swelling face 11.32 9.74 219 173507 81133 90373588
Tricuspid valve disease 11.31 9.74 7 173719 282 90454439
Tenosynovitis 11.24 9.74 7 173719 14560 90440161
Foramen magnum stenosis 11.21 9.74 6 173720 183 90454538
Withdrawal catatonia 11.15 9.74 6 173720 185 90454536
Hypoglycaemia 11.11 9.74 192 173534 69656 90385065
Substance-induced psychotic disorder 11.11 9.74 20 173706 2892 90451829
Infantile apnoea 11.07 9.74 13 173713 1274 90453447
Extremity contracture 11.02 9.74 13 173713 1280 90453441
Personality change 11.02 9.74 35 173691 7286 90447435
Tarsal tunnel syndrome 10.97 9.74 9 173717 568 90454153
Therapy interrupted 10.96 9.74 54 173672 50054 90404667
Gastrointestinal hypomotility 10.93 9.74 13 173713 1292 90453429
Blood bilirubin abnormal 10.92 9.74 16 173710 1948 90452773
Long QT syndrome 10.90 9.74 24 173702 4013 90450708
Confusional arousal 10.88 9.74 7 173719 302 90454419
Urinary bladder rupture 10.86 9.74 6 173720 195 90454526
Increased appetite 10.81 9.74 48 173678 11717 90443004
Placental infarction 10.78 9.74 7 173719 307 90454414
Libido decreased 10.77 9.74 20 173706 2962 90451759
Cardiomyopathy 10.76 9.74 71 173655 20135 90434586
Therapeutic response shortened 10.75 9.74 17 173709 22862 90431859
Intervertebral disc protrusion 10.74 9.74 89 173637 27107 90427614
Somnolence neonatal 10.63 9.74 5 173721 115 90454606
Lip swelling 10.60 9.74 117 173609 38493 90416228
Chronic hepatitis 10.58 9.74 12 173714 1133 90453588
Apraxia 10.56 9.74 17 173709 2245 90452476
Hepatomegaly 10.51 9.74 52 173674 13274 90441447
Eye injury 10.47 9.74 4 173722 11016 90443705
Enlarged cerebral perivascular spaces 10.43 9.74 3 173723 15 90454706
Metastases to liver 10.41 9.74 25 173701 28782 90425939
Echolalia 10.40 9.74 7 173719 326 90454395
Normal newborn 10.38 9.74 18 173708 23344 90431377
Selective eating disorder 10.38 9.74 16 173710 2037 90452684
Urine odour abnormal 10.33 9.74 34 173692 7210 90447511
Microcephaly 10.31 9.74 13 173713 1371 90453350
Accidental exposure to product 10.25 9.74 44 173682 42322 90412399
Tachypnoea 10.24 9.74 73 173653 21236 90433485
Retroperitoneal fibrosis 10.20 9.74 7 173719 337 90454384
Polydipsia 10.15 9.74 24 173702 4207 90450514
Leukopenia 10.14 9.74 134 173592 100576 90354145
Substance use 10.13 9.74 12 173714 1187 90453534
Abnormal faeces 10.11 9.74 32 173694 6650 90448071
Multiple injuries 10.09 9.74 15 173711 1850 90452871
Neurogenic bladder 10.09 9.74 22 173704 3656 90451065
Thoracic outlet syndrome 10.08 9.74 8 173718 482 90454239
Self-destructive behaviour 10.06 9.74 8 173718 483 90454238
Restrictive pulmonary disease 10.02 9.74 17 173709 2345 90452376
Immobile 10.01 9.74 31 173695 6367 90448354
Feeding intolerance 10.01 9.74 11 173715 1003 90453718
Pneumonitis 10.01 9.74 47 173679 44123 90410598
Metabolic syndrome 9.98 9.74 15 173711 1867 90452854
Stress 9.97 9.74 215 173511 81180 90373541
Brain operation 9.94 9.74 9 173717 650 90454071
Allodynia 9.92 9.74 11 173715 1013 90453708
Influenza like illness 9.90 9.74 213 173513 80398 90374323
Duodenal ulcer 9.88 9.74 3 173723 9549 90445172
Drug level below therapeutic 9.88 9.74 29 173697 5785 90448936
Staring 9.86 9.74 14 173712 1656 90453065
Systolic dysfunction 9.85 9.74 15 173711 1889 90452832
Loss of control of legs 9.84 9.74 13 173713 1437 90453284
Laboratory test abnormal 9.80 9.74 44 173682 41810 90412911
Melaena 9.79 9.74 34 173692 34763 90419958
Pulmonary valve incompetence 9.79 9.74 14 173712 1667 90453054
Panniculitis 9.78 9.74 8 173718 14450 90440271
Breathing-related sleep disorder 9.76 9.74 5 173721 139 90454582
Gastrointestinal toxicity 9.75 9.74 3 173723 9464 90445257
Hypermagnesaemia 9.74 9.74 12 173714 1237 90453484

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug abuse 5765.42 11.45 3674 122428 101097 42394136
Toxicity to various agents 4858.50 11.45 4554 121548 224582 42270651
Coma 1903.03 11.45 1440 124662 52114 42443119
Drug dependence 1289.37 11.45 895 125207 28199 42467034
Drug use disorder 1253.87 11.45 612 125490 9721 42485512
Overdose 1192.53 11.45 1511 124591 103753 42391480
Poisoning 1136.62 11.45 644 125458 14055 42481178
Miosis 1071.86 11.45 601 125501 12845 42482388
Substance use disorder 1023.30 11.45 435 125667 4910 42490323
Intentional overdose 957.11 11.45 957 125145 50499 42444734
Somnolence 932.39 11.45 1570 124532 139535 42355698
Completed suicide 904.71 11.45 1263 124839 95202 42400031
Suicide attempt 789.13 11.45 820 125282 45280 42449953
Intentional product misuse 738.98 11.45 913 125189 60987 42434246
Substance abuse 704.08 11.45 396 125706 8509 42486724
Poisoning deliberate 700.79 11.45 413 125689 9721 42485512
Respiratory arrest 617.36 11.45 576 125526 27848 42467385
Aggression 576.81 11.45 682 125420 43481 42451752
Respiratory depression 535.19 11.45 445 125657 18423 42476810
Depressed level of consciousness 509.74 11.45 668 125434 47302 42447931
Bradypnoea 502.40 11.45 250 125852 4143 42491090
Agitation 488.20 11.45 763 125339 63551 42431682
Altered state of consciousness 412.30 11.45 470 125632 28789 42466444
Cardio-respiratory arrest 409.76 11.45 670 125432 57966 42437267
Febrile neutropenia 353.11 11.45 62 126040 185641 42309592
Mydriasis 337.97 11.45 248 125854 8522 42486711
Suicidal ideation 334.65 11.45 549 125553 47612 42447621
Pneumonia aspiration 332.09 11.45 559 125543 49519 42445714
Neuroleptic malignant syndrome 331.82 11.45 362 125740 21110 42474123
Drug withdrawal syndrome 329.01 11.45 361 125741 21188 42474045
Accidental overdose 325.12 11.45 410 125692 27920 42467313
Asphyxia 306.38 11.45 229 125873 8097 42487136
Diarrhoea 294.51 11.45 575 125527 460274 42034959
Drug interaction 287.01 11.45 1550 124552 265449 42229784
Intentional self-injury 286.41 11.45 285 125817 14917 42480316
Withdrawal syndrome 271.00 11.45 273 125829 14502 42480731
Sopor 262.67 11.45 255 125847 12947 42482286
Visceral congestion 232.62 11.45 92 126010 849 42494384
Cardiac arrest 226.48 11.45 775 125327 108545 42386688
Dysarthria 215.80 11.45 407 125695 39400 42455833
Off label use 201.49 11.45 1091 125011 637244 41857989
Anaemia 199.90 11.45 326 125776 279952 42215281
Bradyphrenia 191.97 11.45 144 125958 5118 42490115
Brain oedema 188.40 11.45 237 125865 16090 42479143
Disease progression 172.23 11.45 106 125996 143550 42351683
Drug abuser 171.33 11.45 115 125987 3416 42491817
Restlessness 171.02 11.45 309 125793 28940 42466293
Sedation 170.66 11.45 316 125786 30159 42465074
Dyspnoea 169.45 11.45 705 125397 441916 42053317
Rash 162.51 11.45 362 125740 276592 42218641
Logorrhoea 162.17 11.45 102 126000 2705 42492528
Coma scale abnormal 160.06 11.45 122 125980 4443 42490790
Tachycardia 157.27 11.45 654 125448 100433 42394800
Loss of consciousness 155.20 11.45 612 125490 91742 42403491
Abnormal behaviour 150.28 11.45 276 125826 26175 42469058
COVID-19 145.41 11.45 81 126021 115867 42379366
Salivary hypersecretion 142.72 11.45 169 125933 10774 42484459
Pulmonary oedema 141.75 11.45 412 125690 52860 42442373
Psychotic disorder 141.67 11.45 285 125817 28923 42466310
Hypothermia 140.16 11.45 179 125923 12336 42482897
Prescription drug used without a prescription 139.92 11.45 92 126010 2638 42492595
Malignant neoplasm progression 136.98 11.45 75 126027 108325 42386908
Arthralgia 135.88 11.45 250 125852 204988 42290245
Seizure 134.56 11.45 708 125394 119853 42375380
Confusional state 133 11.45 900 125202 166697 42328536
Pneumonia 131.30 11.45 724 125378 421425 42073808
Sepsis 126.52 11.45 249 125853 199085 42296148
Fatigue 125.40 11.45 766 125336 434875 42060358
Cough 123.23 11.45 211 125891 177892 42317341
Pulmonary congestion 122.49 11.45 189 125913 15541 42479692
Acute kidney injury 121.39 11.45 617 125485 366720 42128513
Pancytopenia 121.32 11.45 102 126000 117641 42377592
Drug screen positive 120.35 11.45 99 126003 4032 42491201
Nausea 115.03 11.45 696 125406 396103 42099130
Housebound 114.11 11.45 38 126064 201 42495032
Extrapyramidal disorder 113.78 11.45 187 125915 16225 42479008
Akathisia 113.15 11.45 147 125955 10304 42484929
Thrombocytopenia 112.06 11.45 248 125854 190031 42305202
Disturbance in attention 110.16 11.45 261 125841 29605 42465628
Drug detoxification 106.24 11.45 41 126061 352 42494881
Alcohol abuse 105.52 11.45 91 126011 3958 42491275
Accidental death 105.03 11.45 81 126021 3002 42492231
Bradykinesia 104.38 11.45 103 125999 5333 42489900
Electrocardiogram QT prolonged 103.64 11.45 345 125757 47600 42447633
Atrial fibrillation 103.45 11.45 158 125944 139435 42355798
Disorientation 102.19 11.45 287 125815 36102 42459131
Anxiety 102.07 11.45 650 125452 117910 42377323
Dystonia 100.04 11.45 154 125948 12636 42482597
Pruritus 99.31 11.45 261 125841 188510 42306723
Delusion 98.28 11.45 165 125937 14569 42480664
Rhabdomyolysis 95.96 11.45 471 125631 77548 42417685
Pyrexia 95.32 11.45 729 125373 393313 42101920
Product use in unapproved indication 94.78 11.45 258 125844 184198 42311035
Psychomotor hyperactivity 91.47 11.45 136 125966 10822 42484411
Interstitial lung disease 91.08 11.45 60 126042 78402 42416831
Delirium 89.74 11.45 350 125752 52169 42443064
Abdominal pain 89.42 11.45 278 125824 190193 42305040
Cardiac failure congestive 84.71 11.45 77 126025 85525 42409708
Arteriosclerosis coronary artery 83.21 11.45 176 125926 18501 42476732
Cytokine release syndrome 82.06 11.45 16 126086 44511 42450722
Product dose omission issue 81.48 11.45 213 125889 154152 42341081
Thinking abnormal 81.09 11.45 103 125999 7058 42488175
Mucosal inflammation 80.62 11.45 23 126079 49351 42445882
Myelosuppression 80.15 11.45 12 126090 40449 42454784
Drug ineffective 80.00 11.45 1349 124753 628848 41866385
Platelet count decreased 77.99 11.45 185 125917 138396 42356837
Sudden death 77.94 11.45 160 125942 16469 42478764
Dyspnoea exertional 77.15 11.45 26 126076 50122 42445111
Accidental poisoning 77.15 11.45 48 126054 1248 42493985
General physical health deterioration 76.58 11.45 213 125889 151033 42344200
Inappropriate schedule of product administration 76.50 11.45 103 125999 95799 42399434
Joint swelling 76.30 11.45 54 126048 67968 42427265
Drug intolerance 75.31 11.45 76 126026 80348 42414885
Weight decreased 75.10 11.45 338 125764 207610 42287623
Alcohol interaction 74.72 11.45 57 126045 2078 42493155
Paranoia 74.22 11.45 142 125960 13884 42481349
Infusion related reaction 74.02 11.45 44 126058 60762 42434471
Mental impairment 73.09 11.45 131 125971 12186 42483047
Panic attack 72.74 11.45 123 125979 10922 42484311
Suicidal behaviour 71.78 11.45 49 126053 1497 42493736
Irritability 71.41 11.45 214 125888 27914 42467319
Psychotic symptom 69.04 11.45 57 126045 2333 42492900
Haemoglobin decreased 68.97 11.45 184 125918 132287 42362946
Prostate cancer 68.93 11.45 23 126079 44620 42450613
Exposure via ingestion 68.49 11.45 54 126048 2068 42493165
Drug withdrawal convulsions 68.35 11.45 45 126057 1293 42493940
Alcohol poisoning 67.56 11.45 97 126005 7477 42487756
Haematochezia 67.39 11.45 45 126057 58391 42436842
Erythema 67.14 11.45 138 125964 108655 42386578
Sedation complication 66.90 11.45 61 126041 2858 42492375
Oedema peripheral 66.41 11.45 195 125907 135881 42359352
Neutropenia 66.24 11.45 334 125768 199097 42296136
Psychotic behaviour 66.24 11.45 39 126063 915 42494318
Ascites 66.23 11.45 43 126059 56635 42438598
Sinus tachycardia 66.12 11.45 171 125931 20482 42474751
Peripheral swelling 66.05 11.45 103 125999 90167 42405066
Mood swings 65.86 11.45 104 125998 8722 42486511
Infection 65.14 11.45 147 125955 111921 42383312
Pleural effusion 64.52 11.45 118 125984 97048 42398185
Nasopharyngitis 64.20 11.45 93 126009 83903 42411330
Status epilepticus 63.91 11.45 142 125960 15436 42479797
Renal impairment 63.73 11.45 145 125957 110083 42385150
Rheumatoid arthritis 63.57 11.45 23 126079 42417 42452816
Cytomegalovirus infection 63.04 11.45 10 126092 32296 42462937
Epistaxis 62.74 11.45 63 126039 66763 42428470
Parkinsonism 61.78 11.45 112 125990 10511 42484722
Behaviour disorder 60.97 11.45 89 126013 6965 42488268
Antipsychotic drug level increased 60.74 11.45 72 126030 4594 42490639
Nystagmus 60.13 11.45 77 126025 5319 42489914
Respiratory acidosis 59.31 11.45 83 126019 6248 42488985
Stomatitis 59.06 11.45 38 126064 50291 42444942
Toxicologic test abnormal 58.78 11.45 29 126073 471 42494762
Drug withdrawal syndrome neonatal 58.34 11.45 69 126033 4392 42490841
Asthenia 58.05 11.45 541 125561 280252 42214981
Gastrointestinal haemorrhage 57.76 11.45 127 125975 97599 42397634
Substance abuser 57.70 11.45 24 126078 255 42494978
Thrombosis 57.29 11.45 71 126031 68440 42426793
Anger 57.20 11.45 122 125980 12896 42482337
Hypoventilation 56.80 11.45 63 126039 3739 42491494
Hypertonia 56.73 11.45 72 126030 4929 42490304
Persecutory delusion 56.63 11.45 61 126041 3503 42491730
Generalised tonic-clonic seizure 56.26 11.45 189 125913 26190 42469043
Decreased appetite 56.16 11.45 338 125764 192799 42302434
Unresponsive to stimuli 55.86 11.45 212 125890 31191 42464042
Self-medication 55.62 11.45 58 126044 3208 42492025
Aspiration 55.12 11.45 146 125956 17740 42477493
Self-injurious ideation 54.90 11.45 45 126057 1823 42493410
Neuropathy peripheral 54.90 11.45 139 125963 101714 42393519
Asthma 53.78 11.45 63 126039 62251 42432982
Tremor 53.65 11.45 479 125623 96450 42398783
Cerebrovascular accident 52.83 11.45 132 125970 97028 42398205
Blood creatine phosphokinase increased 51.20 11.45 280 125822 48058 42447175
Epilepsy 51.02 11.45 182 125920 25989 42469244
Insomnia 50.66 11.45 554 125548 117699 42377534
Serotonin syndrome 50.61 11.45 180 125922 25665 42469568
Full blood count abnormal 50.50 11.45 13 126089 29863 42465370
Depression 50.16 11.45 527 125575 110836 42384397
Tension 49.76 11.45 48 126054 2416 42492817
Pneumonitis 49.63 11.45 31 126071 41687 42453546
Injection site pain 49.27 11.45 59 126043 57739 42437494
Pneumocystis jirovecii pneumonia 48.67 11.45 8 126094 25173 42470060
Hallucination, auditory 48.54 11.45 124 125978 14740 42480493
Bladder dilatation 48.18 11.45 40 126062 1650 42493583
International normalised ratio increased 48.03 11.45 43 126059 48125 42447108
Schizophrenia 47.66 11.45 100 126002 10450 42484783
Tubulointerstitial nephritis 47.41 11.45 17 126085 31531 42463702
Postmortem blood drug level abnormal 47.32 11.45 23 126079 361 42494872
Coordination abnormal 46.97 11.45 85 126017 7965 42487268
Productive cough 46.83 11.45 50 126052 51517 42443716
Dependence 46.35 11.45 37 126065 1443 42493790
Anterograde amnesia 46.33 11.45 21 126081 279 42494954
Drug withdrawal maintenance therapy 45.71 11.45 18 126084 164 42495069
Bronchopulmonary aspergillosis 45.64 11.45 3 126099 19426 42475807
Acute myeloid leukaemia 45.49 11.45 6 126096 22250 42472983
Opiates positive 45.06 11.45 25 126077 522 42494711
Blood pressure increased 44.84 11.45 153 125949 101775 42393458
Colitis 44.75 11.45 43 126059 46529 42448704
Wheezing 44.52 11.45 58 126044 54723 42440510
Pulmonary fibrosis 44.35 11.45 12 126090 26669 42468564
Chills 44.29 11.45 137 125965 93929 42401304
Non-cardiogenic pulmonary oedema 44.28 11.45 30 126072 905 42494328
Echolalia 44.06 11.45 22 126080 367 42494866
Bradycardia 44.03 11.45 416 125686 85068 42410165
Psychomotor skills impaired 44.02 11.45 65 126037 5139 42490094
Tumour lysis syndrome 43.11 11.45 7 126095 22224 42473009
Pain in extremity 43.01 11.45 265 125837 150339 42344894
Social anxiety disorder 42.67 11.45 25 126077 581 42494652
Arthritis 42.60 11.45 37 126065 42028 42453205
Abdominal distension 41.74 11.45 94 126008 71641 42423592
Hyperhidrosis 41.53 11.45 430 125672 90082 42405151
Blood pressure fluctuation 41.30 11.45 14 126088 26894 42468339
Colitis ulcerative 41.26 11.45 13 126089 26162 42469071
Homicidal ideation 41.23 11.45 46 126056 2748 42492485
Palmar-plantar erythrodysaesthesia syndrome 41.00 11.45 6 126096 20576 42474657
Muscle rigidity 40.84 11.45 102 126000 11957 42483276
Condition aggravated 40.50 11.45 536 125566 260218 42235015
Memory impairment 40.50 11.45 271 125831 49951 42445282
Haematuria 40.34 11.45 68 126034 57731 42437502
Abdominal discomfort 40.31 11.45 103 125999 75152 42420081
Emotional disorder 39.85 11.45 69 126033 6245 42488988
Amnesia 39.56 11.45 178 125924 28259 42466974
Mental disorder 39.17 11.45 130 125972 17899 42477334
Schizoaffective disorder 39.08 11.45 38 126064 1932 42493301
Frequent bowel movements 38.80 11.45 8 126094 21399 42473834
Angioedema 38.78 11.45 41 126061 42436 42452797
Drug diversion 38.22 11.45 28 126074 959 42494274
Vestibular disorder 38.09 11.45 30 126072 1147 42494086
Plasma cell myeloma 38.02 11.45 51 126051 47527 42447706
Rectal haemorrhage 37.82 11.45 55 126047 49551 42445682
Hypotonia 37.19 11.45 85 126017 9414 42485819
Cardiac failure 37.14 11.45 176 125926 106680 42388553
Anaphylactic reaction 37.10 11.45 43 126059 42700 42452533
Hyperthermia 37.09 11.45 101 126001 12473 42482760
Myelodysplastic syndrome 36.38 11.45 11 126091 22734 42472499
Myocardial depression 36.30 11.45 14 126088 120 42495113
Brain injury 36.27 11.45 74 126028 7581 42487652
Loss of personal independence in daily activities 36.27 11.45 57 126045 49759 42445474
Dizziness 35.97 11.45 520 125582 248734 42246499
Hallucination 35.92 11.45 292 125810 57215 42438018
Treatment failure 35.67 11.45 83 126019 62541 42432692
Urticaria 35.44 11.45 107 125995 73929 42421304
Encephalitis toxic 35.37 11.45 17 126085 260 42494973
Catatonia 35.29 11.45 65 126037 6174 42489059
Depressed mood 35.29 11.45 150 125952 23234 42471999
Cytopenia 35.09 11.45 5 126097 17492 42477741
Sleep disorder due to a general medical condition 34.97 11.45 5 126097 17448 42477785
Ataxia 34.79 11.45 116 125986 16009 42479224
Hypomagnesaemia 34.12 11.45 21 126081 28467 42466766
Psoriasis 34.09 11.45 57 126045 48547 42446686
Acute myocardial infarction 34.01 11.45 76 126026 58089 42437144
Neoplasm progression 33.88 11.45 22 126080 28978 42466255
Hypophosphataemia 33.74 11.45 10 126092 20935 42474298
Dry skin 33.61 11.45 57 126045 48281 42446952
Nervousness 33.44 11.45 102 126000 13430 42481803
Chest discomfort 33.36 11.45 88 126014 63528 42431705
Substance use 33.29 11.45 33 126069 1718 42493515
Homicide 33.28 11.45 25 126077 890 42494343
Cardiomegaly 33.02 11.45 117 125985 16649 42478584
Agoraphobia 32.87 11.45 16 126086 252 42494981
Clostridium difficile infection 32.73 11.45 13 126089 22646 42472587
White blood cell count decreased 32.68 11.45 192 125910 110204 42385029
Arthropathy 32.52 11.45 24 126078 29573 42465660
Bone marrow failure 32.44 11.45 30 126072 33063 42462170
Dyskinesia 32.42 11.45 155 125947 25235 42469998
Potentiating drug interaction 32.41 11.45 64 126038 6404 42488829
Dehydration 32.39 11.45 266 125836 141501 42353732
Prescription form tampering 32.28 11.45 21 126081 591 42494642
Electroencephalogram abnormal 32.25 11.45 42 126060 2950 42492283
Swelling 31.86 11.45 72 126030 54813 42440420
Hypoxic-ischaemic encephalopathy 31.73 11.45 56 126046 5146 42490087
Rash pruritic 31.16 11.45 32 126070 33571 42461662
Acute psychosis 31.06 11.45 35 126067 2114 42493119
Leukopenia 30.99 11.45 115 125987 74631 42420602
Pyramidal tract syndrome 30.86 11.45 16 126086 290 42494943
Diabetes mellitus 30.84 11.45 84 126018 60003 42435230
Chronic kidney disease 30.78 11.45 58 126044 47183 42448050
Septic shock 30.69 11.45 153 125949 91519 42403714
Hypervolaemia 30.67 11.45 15 126087 23110 42472123
Bacteraemia 30.63 11.45 18 126084 25022 42470211
Fluid retention 30.60 11.45 29 126073 31590 42463643
Hepatocellular injury 30.56 11.45 145 125957 23533 42471700
Myocarditis 30.55 11.45 124 125978 18814 42476419
Drug hypersensitivity 30.42 11.45 171 125931 99218 42396015
Blood alcohol increased 30.21 11.45 20 126082 580 42494653
Hepatic cytolysis 30.12 11.45 158 125944 26686 42468547
Muscle spasticity 30.05 11.45 64 126038 6758 42488475
Poor quality sleep 30.05 11.45 78 126024 9362 42485871
Blood uric acid increased 29.91 11.45 5 126097 15542 42479691
Congestive hepatopathy 29.76 11.45 36 126066 2346 42492887
Herpes zoster 29.74 11.45 43 126059 38834 42456399
Facial spasm 29.73 11.45 14 126088 204 42495029
Transplant rejection 29.42 11.45 3 126099 13585 42481648
Necrotising colitis 29.27 11.45 27 126075 1284 42493949
Hallucinations, mixed 29.19 11.45 43 126059 3392 42491841
Myocardial infarction 29.10 11.45 231 125871 123778 42371455
Chronic obstructive pulmonary disease 28.94 11.45 93 126009 63021 42432212
Bacterial infection 28.87 11.45 24 126078 27855 42467378
Hypercapnic coma 28.66 11.45 13 126089 173 42495060
Mania 28.44 11.45 82 126020 10465 42484768
Treatment noncompliance 28.42 11.45 200 125902 37472 42457761
Bronchiectasis 28.31 11.45 9 126093 18010 42477223
Basal cell carcinoma 28.29 11.45 16 126086 22717 42472516
Therapeutic product effect incomplete 28.21 11.45 111 125991 70828 42424405
Hallucination, tactile 28.17 11.45 19 126083 569 42494664
Hypothyroidism 28.15 11.45 32 126070 32052 42463181
Impaired driving ability 28.06 11.45 39 126063 2916 42492317
Pulmonary embolism 27.97 11.45 223 125879 119389 42375844
Electrolyte imbalance 27.85 11.45 8 126094 17093 42478140
Full blood count decreased 27.78 11.45 13 126089 20547 42474686
Delusional disorder, unspecified type 27.66 11.45 21 126081 760 42494473
Blood creatinine increased 27.65 11.45 201 125901 109802 42385431
Andropause 27.58 11.45 11 126091 104 42495129
Accident 27.49 11.45 60 126042 6443 42488790
Cellulitis 27.37 11.45 92 126010 61493 42433740
Haemoptysis 27.26 11.45 60 126042 46107 42449126
Skin exfoliation 27.09 11.45 51 126051 41502 42453731
Oral discharge 27.05 11.45 12 126090 151 42495082
Road traffic accident 26.92 11.45 120 125982 18973 42476260
Daydreaming 26.85 11.45 20 126082 703 42494530
Renal failure 26.67 11.45 284 125818 143442 42351791
Blood pressure systolic increased 26.66 11.45 26 126076 27942 42467291
Victim of chemical submission 26.57 11.45 12 126090 158 42495075
Illusion 26.56 11.45 23 126079 1006 42494227
Blood phosphorus increased 26.52 11.45 3 126099 12522 42482711
Fatty liver alcoholic 26.51 11.45 9 126093 51 42495182
Speech disorder 26.47 11.45 162 125940 28959 42466274
Liver disorder 26.43 11.45 48 126054 39596 42455637
Back pain 26.37 11.45 280 125822 141496 42353737
Mononeuropathy 26.27 11.45 14 126088 269 42494964
Multiple organ dysfunction syndrome 26.01 11.45 174 125928 96861 42398372
Nephrolithiasis 26.00 11.45 43 126059 36787 42458446
Metastases to liver 25.93 11.45 8 126094 16318 42478915
Spleen congestion 25.86 11.45 15 126087 342 42494891
Osteonecrosis of jaw 25.81 11.45 12 126090 19037 42476196
Melaena 25.75 11.45 47 126055 38699 42456534
Pupillary disorder 25.74 11.45 15 126087 345 42494888
Cerebral haemorrhage 25.25 11.45 48 126054 38918 42456315
Diet refusal 25.03 11.45 14 126088 297 42494936
High risk sexual behaviour 25.03 11.45 10 126092 95 42495138
Sexual abuse 24.97 11.45 11 126091 136 42495097
Appendicitis 24.96 11.45 15 126087 20598 42474635
Anti factor V antibody 24.87 11.45 14 126088 301 42494932
Abdominal pain upper 24.80 11.45 143 125959 82466 42412767
Penis injury 24.57 11.45 13 126089 246 42494987
Reflexes abnormal 24.56 11.45 15 126087 377 42494856
Stiff person syndrome 24.26 11.45 12 126090 196 42495037
Cataract 24.25 11.45 33 126069 30571 42464662
Psoriatic arthropathy 24.04 11.45 23 126079 24944 42470289
Crystalluria 24.02 11.45 19 126083 731 42494502
Prostatic specific antigen increased 23.97 11.45 10 126092 16915 42478318
Haemophagocytic lymphohistiocytosis 23.89 11.45 12 126090 18210 42477023
Upper gastrointestinal haemorrhage 23.68 11.45 33 126069 30266 42464967
Autonomic nervous system imbalance 23.64 11.45 37 126065 3079 42492154
Physical assault 23.61 11.45 22 126080 1060 42494173
Basilar migraine 23.49 11.45 6 126096 9 42495224
Drug level increased 23.34 11.45 145 125957 26055 42469178
Haemorrhage 23.30 11.45 96 126006 60467 42434766
Patient restraint 23.25 11.45 9 126093 78 42495155
Deep vein thrombosis 23.22 11.45 133 125969 76824 42418409
Dysgeusia 23.14 11.45 41 126061 34148 42461085
Hallucination, visual 23.09 11.45 123 125979 20897 42474336
Skin ulcer 23.04 11.45 25 126077 25576 42469657
Aspartate aminotransferase increased 22.94 11.45 134 125968 77029 42418204
Inadequate analgesia 22.93 11.45 37 126065 3160 42492073
Skin lesion 22.88 11.45 28 126074 27146 42468087
Coronary artery disease 22.70 11.45 82 126020 53638 42441595
Gas poisoning 22.57 11.45 9 126093 85 42495148
Sluggishness 22.56 11.45 41 126061 3855 42491378
Alcoholism 22.52 11.45 35 126067 2895 42492338
Hypersensitivity 22.42 11.45 124 125978 72246 42422987
Victim of crime 22.33 11.45 16 126086 529 42494704
Swollen tongue 22.33 11.45 18 126084 21213 42474020
Intentional product use issue 22.29 11.45 123 125979 71710 42423523
Personal relationship issue 22.23 11.45 13 126089 301 42494932
Hanging 22.22 11.45 11 126091 180 42495053
Metastases to bone 22.22 11.45 8 126094 14801 42480432
Thrombotic microangiopathy 22.15 11.45 8 126094 14774 42480459
Myasthenia gravis 22.12 11.45 10 126092 16127 42479106
Therapy interrupted 22.01 11.45 20 126082 22230 42473003
Polyneuropathy 22.01 11.45 14 126088 18647 42476586
Abnormal dreams 22.01 11.45 64 126038 8207 42487026
Breech presentation 21.95 11.45 11 126091 185 42495048
Stupor 21.95 11.45 36 126066 3117 42492116
Pancreatitis 21.82 11.45 61 126041 43207 42452026
Obsessive thoughts 21.78 11.45 19 126083 839 42494394
Pathogen resistance 21.33 11.45 4 126098 11446 42483787
Bladder cancer 21.21 11.45 12 126090 17035 42478198
Eczema 21.21 11.45 43 126059 34043 42461190
Clostridium difficile colitis 21.15 11.45 19 126083 21233 42474000
Graft versus host disease 21.13 11.45 6 126096 12919 42482314
Vitamin D abnormal 21.11 11.45 8 126094 65 42495168
Irregular breathing 21.11 11.45 12 126090 263 42494970
Urinary retention 21.01 11.45 204 125898 42010 42453223
Blepharospasm 21.01 11.45 23 126079 1345 42493888
Oedema 20.91 11.45 81 126021 51920 42443313
Synovitis 20.79 11.45 10 126092 15557 42479676
Muscular weakness 20.77 11.45 153 125949 83345 42411888
Osmolar gap abnormal 20.72 11.45 7 126095 39 42495194
Traumatic coma 20.69 11.45 6 126096 18 42495215
Incoherent 20.69 11.45 44 126058 4641 42490592
Postmortem blood drug level increased 20.67 11.45 15 126087 506 42494727
Neutrophil count decreased 20.56 11.45 107 125995 63308 42431925
Respiratory symptom 20.44 11.45 4 126098 11102 42484131
Personality disorder 20.43 11.45 21 126081 1142 42494091
Flushing 20.35 11.45 50 126052 36978 42458255
Fear 20.30 11.45 75 126027 10890 42484343
Clinomania 20.29 11.45 7 126095 42 42495191
Ex-drug abuser 20.21 11.45 8 126094 74 42495159
Opisthotonus 20.17 11.45 16 126086 618 42494615
Nodule 20.16 11.45 6 126096 12528 42482705
Cyanosis 20.09 11.45 93 126009 14938 42480295
Stereotypy 20.09 11.45 18 126084 824 42494409
Wrong patient 20.06 11.45 16 126086 623 42494610
Tuberculosis 19.99 11.45 3 126099 10096 42485137
Alcoholic coma 19.93 11.45 8 126094 77 42495156
Ulcer 19.85 11.45 12 126090 16429 42478804
Behavioural addiction 19.75 11.45 8 126094 79 42495154
Lethargy 19.74 11.45 219 125883 46671 42448562
Diverticulitis 19.67 11.45 23 126079 22750 42472483
COVID-19 pneumonia 19.57 11.45 21 126081 21592 42473641
Hospitalisation 19.56 11.45 134 125968 74196 42421037
Cardiopulmonary failure 19.56 11.45 43 126059 4640 42490593
Dissociation 19.54 11.45 38 126064 3760 42491473
Rash erythematous 19.53 11.45 41 126061 32050 42463183
Product communication issue 19.43 11.45 20 126082 1089 42494144
Lymphoma 19.43 11.45 9 126093 14312 42480921
Impaired self-care 19.35 11.45 21 126081 1216 42494017
Benzodiazepine drug level abnormal 19.30 11.45 4 126098 0 42495233
Drug-induced liver injury 19.26 11.45 54 126048 38219 42457014
Suicide threat 19.25 11.45 7 126095 50 42495183
Crime 19.13 11.45 7 126095 51 42495182
Rhinorrhoea 19.03 11.45 41 126061 31753 42463480
Myalgia 18.99 11.45 187 125915 95893 42399340
Claustrophobia 18.98 11.45 12 126090 321 42494912
Personality change 18.97 11.45 48 126054 5671 42489562
Injury 18.94 11.45 122 125980 22194 42473039
Squamous cell carcinoma of skin 18.88 11.45 7 126095 12719 42482514
Neutropenic sepsis 18.76 11.45 12 126090 15934 42479299
Gout 18.67 11.45 34 126068 28021 42467212
Hostility 18.65 11.45 17 126085 796 42494437
Biliary ischaemia 18.60 11.45 8 126094 93 42495140
Somnambulism 18.59 11.45 35 126067 3380 42491853
Flat affect 18.56 11.45 19 126083 1028 42494205
Delusion of reference 18.52 11.45 8 126094 94 42495139
Pulmonary contusion 18.52 11.45 8 126094 94 42495139
Priapism 18.44 11.45 51 126051 6356 42488877
Spasmodic dysphonia 18.43 11.45 14 126088 507 42494726
Angina pectoris 18.41 11.45 44 126058 32852 42462381
Term birth 18.37 11.45 8 126094 96 42495137
Inflammation 18.37 11.45 46 126056 33801 42461432
Hyperkalaemia 18.34 11.45 151 125951 80307 42414926
White blood cell count increased 18.26 11.45 209 125893 44878 42450355
Drug tolerance 18.26 11.45 34 126068 3256 42491977
Needle track marks 18.25 11.45 7 126095 59 42495174
Cerebral congestion 18.15 11.45 8 126094 99 42495134
Haematotoxicity 18.15 11.45 5 126097 10980 42484253
Febrile bone marrow aplasia 18.05 11.45 4 126098 10177 42485056
Libido disorder 18.04 11.45 12 126090 351 42494882
Executive dysfunction 17.99 11.45 11 126091 277 42494956
Adverse drug reaction 17.98 11.45 54 126048 37380 42457853
Ventricular fibrillation 17.90 11.45 39 126063 30084 42465149
Affect lability 17.88 11.45 38 126064 4006 42491227
Headache 17.77 11.45 556 125546 238813 42256420
Myositis 17.74 11.45 11 126091 14855 42480378
Enteritis 17.72 11.45 5 126097 10811 42484422
Vasculitis 17.65 11.45 17 126085 18377 42476856
Apnoea 17.61 11.45 57 126045 7746 42487487
Torticollis 17.60 11.45 21 126081 1349 42493884
Reaction to excipient 17.50 11.45 15 126087 647 42494586
Substance dependence 17.50 11.45 15 126087 647 42494586
Seizure cluster 17.44 11.45 11 126091 293 42494940
Sensory integrative dysfunction 17.39 11.45 6 126096 36 42495197
Kidney congestion 17.38 11.45 13 126089 460 42494773
Therapeutic response decreased 17.34 11.45 54 126048 36958 42458275
Ejaculation delayed 17.28 11.45 11 126091 298 42494935
Hangover 17.25 11.45 19 126083 1119 42494114
Enterococcal infection 17.23 11.45 7 126095 12032 42483201
Hepatotoxicity 17.20 11.45 30 126072 25137 42470096
Lung disorder 17.19 11.45 78 126024 47845 42447388
Post-traumatic stress disorder 17.15 11.45 27 126075 2258 42492975
Localised infection 17.14 11.45 21 126081 20352 42474881
Poverty of speech 17.12 11.45 10 126092 231 42495002
Blunted affect 17.06 11.45 12 126090 385 42494848
Subacute endocarditis 16.95 11.45 7 126095 73 42495160
Administration related reaction 16.93 11.45 9 126093 172 42495061
Influenza 16.90 11.45 111 125991 62064 42433169
Apathy 16.84 11.45 59 126043 8347 42486886
Oesophageal carcinoma 16.81 11.45 4 126098 9692 42485541
Impulse-control disorder 16.81 11.45 22 126080 1553 42493680
Pain threshold decreased 16.55 11.45 5 126097 18 42495215
Obstructive airways disorder 16.48 11.45 30 126072 24729 42470504
Cardiac hypertrophy 16.41 11.45 19 126083 1182 42494051
Aura 16.33 11.45 12 126090 413 42494820
Portal tract inflammation 16.27 11.45 8 126094 129 42495104
Dyspepsia 16.25 11.45 65 126037 41287 42453946
Sexually inappropriate behaviour 16.23 11.45 14 126088 609 42494624
Taste disorder 16.21 11.45 5 126097 10202 42485031
Lymphadenopathy 16.12 11.45 48 126054 33317 42461916
Anticonvulsant drug level increased 16.08 11.45 22 126080 1621 42493612
Choking 16.06 11.45 48 126054 6250 42488983
Hypertensive heart disease 16.03 11.45 28 126074 2552 42492681
Rebound psychosis 15.96 11.45 9 126093 194 42495039
Faecal disimpaction 15.95 11.45 5 126097 21 42495212
Injection site swelling 15.92 11.45 16 126086 16957 42478276
Escherichia infection 15.72 11.45 7 126095 11389 42483844
Emotional disorder of childhood 15.70 11.45 6 126096 50 42495183
Rhesus incompatibility 15.70 11.45 6 126096 50 42495183
Uveitis 15.70 11.45 4 126098 9254 42485979
Neurological symptom 15.68 11.45 5 126097 9986 42485247
Drug tolerance increased 15.67 11.45 12 126090 440 42494793
Pneumonia bacterial 15.65 11.45 14 126088 15678 42479555
Mucosal erosion 15.61 11.45 17 126085 988 42494245
Hyperammonaemia 15.58 11.45 55 126047 7811 42487422
Electrocardiogram PR prolongation 15.57 11.45 17 126085 991 42494242
Myofascial pain syndrome 15.56 11.45 11 126091 356 42494877
Pain 15.54 11.45 580 125522 244268 42250965
Cognitive disorder 15.49 11.45 162 125940 34010 42461223
Oral pain 15.48 11.45 9 126093 12587 42482646
Neutrophil count increased 15.44 11.45 106 125996 19698 42475535
Alcohol intolerance 15.42 11.45 11 126091 361 42494872
Pneumonia fungal 15.42 11.45 4 126098 9142 42486091
Adrenal insufficiency 15.41 11.45 20 126082 18904 42476329
Staring 15.19 11.45 21 126081 1562 42493671
Brain death 15.18 11.45 30 126072 3004 42492229
Tardive dyskinesia 15.10 11.45 50 126052 6874 42488359
Clumsiness 15.03 11.45 23 126079 1877 42493356
Congenital pulmonary valve atresia 15.02 11.45 6 126096 57 42495176
Aplastic anaemia 15.01 11.45 9 126093 12375 42482858
Cerebral infarction 14.94 11.45 45 126057 31124 42464109
Chemical poisoning 14.93 11.45 7 126095 101 42495132
Skin fissures 14.91 11.45 5 126097 9671 42485562
Blood pressure diastolic decreased 14.90 11.45 6 126096 10369 42484864
Faeces discoloured 14.89 11.45 17 126085 16997 42478236
Product counterfeit 14.86 11.45 8 126094 157 42495076
Antipsychotic drug level decreased 14.86 11.45 18 126084 1175 42494058
Lung neoplasm malignant 14.82 11.45 21 126081 19126 42476107
Bone pain 14.81 11.45 30 126072 23762 42471471
Femoral nerve palsy 14.75 11.45 6 126096 60 42495173
Stress 14.67 11.45 74 126028 44138 42451095
Slow speech 14.63 11.45 22 126080 1768 42493465
Persistent depressive disorder 14.62 11.45 12 126090 487 42494746
Respiratory rate decreased 14.59 11.45 29 126073 2916 42492317
Drowning 14.56 11.45 12 126090 490 42494743
Oral mucosal eruption 14.54 11.45 11 126091 396 42494837
Protrusion tongue 14.46 11.45 9 126093 234 42494999
Sciatic nerve neuropathy 14.41 11.45 6 126096 64 42495169
Lower gastrointestinal haemorrhage 14.35 11.45 7 126095 10801 42484432
Forearm fracture 14.34 11.45 7 126095 111 42495122
Multiple-drug resistance 14.33 11.45 51 126051 7271 42487962
Long QT syndrome 14.28 11.45 30 126072 3137 42492096
Acidosis 14.28 11.45 73 126029 12206 42483027
Haematocrit decreased 14.27 11.45 54 126048 34854 42460379
Kidney transplant rejection 14.25 11.45 4 126098 8679 42486554
Erectile dysfunction 14.22 11.45 124 125978 24789 42470444
Learning disorder 14.20 11.45 17 126085 1096 42494137
Mobility decreased 14.19 11.45 55 126047 35251 42459982
Drug half-life increased 14.17 11.45 7 126095 114 42495119
Rhinitis 14.10 11.45 9 126093 11968 42483265
Osteomyelitis 14.09 11.45 20 126082 18203 42477030
Neurosis 14.09 11.45 8 126094 175 42495058
Drug level below therapeutic 14.04 11.45 47 126055 6498 42488735
Hypomania 14.02 11.45 26 126076 2482 42492751
Brain hypoxia 13.99 11.45 13 126089 624 42494609
Syringe issue 13.94 11.45 4 126098 8552 42486681
Hypotension 13.92 11.45 912 125190 256719 42238514
Infantile apnoea 13.92 11.45 17 126085 1119 42494114
Paradoxical drug reaction 13.92 11.45 38 126064 4700 42490533
Myocardial fibrosis 13.90 11.45 18 126084 1257 42493976
Starvation 13.87 11.45 12 126090 524 42494709
Dermatitis acneiform 13.80 11.45 3 126099 7736 42487497
Inappropriate antidiuretic hormone secretion 13.78 11.45 90 126012 16451 42478782
Throat irritation 13.77 11.45 11 126091 13025 42482208
Vascular stenosis 13.77 11.45 8 126094 183 42495050
Violence-related symptom 13.76 11.45 12 126090 530 42494703
Squamous cell carcinoma 13.66 11.45 11 126091 12971 42482262
Selective mutism 13.63 11.45 6 126096 74 42495159
Drug eruption 13.61 11.45 30 126072 23045 42472188
Pulmonary valve incompetence 13.60 11.45 17 126085 1146 42494087
Hyponatraemic coma 13.60 11.45 5 126097 37 42495196
Coma acidotic 13.56 11.45 4 126098 13 42495220
Physical abuse 13.56 11.45 4 126098 13 42495220
False positive investigation result 13.55 11.45 13 126089 650 42494583
Penile haemorrhage 13.48 11.45 16 126086 1022 42494211
Gastrooesophageal reflux disease 13.47 11.45 78 126024 44945 42450288
Feeling hot 13.47 11.45 31 126071 23451 42471782
Hypovitaminosis 13.46 11.45 14 126088 772 42494461
Proteinuria 13.46 11.45 30 126072 22953 42472280
Laboratory test abnormal 13.45 11.45 30 126072 22948 42472285
Hyperglycaemia 13.43 11.45 80 126022 45779 42449454
Gallbladder injury 13.43 11.45 8 126094 192 42495041
Patient uncooperative 13.42 11.45 13 126089 658 42494575
Dissociative disorder 13.40 11.45 13 126089 659 42494574
Mood altered 13.37 11.45 65 126037 10653 42484580
Antasthmatic drug level 13.26 11.45 5 126097 40 42495193
Hypotonia neonatal 13.23 11.45 19 126083 1465 42493768
Benzodiazepine drug level increased 13.16 11.45 5 126097 41 42495192
Drooling 13.15 11.45 35 126067 4264 42490969
Ileus paralytic 13.10 11.45 51 126051 7590 42487643
Cardiac failure chronic 13.08 11.45 6 126096 9595 42485638
Staphylococcal infection 13.07 11.45 62 126040 37581 42457652
Family stress 13.07 11.45 7 126095 136 42495097
Syncope 13.07 11.45 211 125891 99195 42396038
Hepatic function abnormal 13.06 11.45 94 126008 51473 42443760
Ischaemic stroke 13.03 11.45 29 126073 22204 42473029
Fungal infection 13.03 11.45 24 126078 19698 42475535
Abdominal pain lower 13.03 11.45 10 126092 12082 42483151
Postprandial hypoglycaemia 13.02 11.45 6 126096 83 42495150
Communication disorder 13.02 11.45 27 126075 2798 42492435
Muscle twitching 12.98 11.45 69 126033 11711 42483522
Skin cancer 12.98 11.45 9 126093 11453 42483780
Analgesic drug level 12.95 11.45 5 126097 43 42495190
Dyssomnia 12.95 11.45 5 126097 43 42495190
Counterfeit product administered 12.90 11.45 9 126093 285 42494948
Metastases to lung 12.89 11.45 9 126093 11415 42483818
Skull fractured base 12.89 11.45 8 126094 207 42495026
Movement disorder 12.87 11.45 81 126021 14617 42480616
Eye pruritus 12.87 11.45 9 126093 11403 42483830
Alopecia 12.82 11.45 44 126058 29232 42466001
Immune reconstitution inflammatory syndrome 12.82 11.45 7 126095 10136 42485097
Tendon rupture 12.76 11.45 4 126098 8079 42487154
Respiratory distress 12.76 11.45 184 125918 41636 42453597
Pulmonary alveolar haemorrhage 12.75 11.45 15 126087 14801 42480432
Immune effector cell-associated neurotoxicity syndrome 12.75 11.45 6 126096 9455 42485778
Blood bilirubin increased 12.75 11.45 73 126029 42179 42453054
Diffuse large B-cell lymphoma 12.74 11.45 6 126096 9448 42485785
Hyperreflexia 12.73 11.45 31 126071 3576 42491657
Oropharyngeal spasm 12.72 11.45 8 126094 212 42495021
Pneumoconiosis 12.68 11.45 9 126093 293 42494940
Judgement impaired 12.66 11.45 12 126090 591 42494642
Aortic stenosis 12.66 11.45 5 126097 8740 42486493
Transient ischaemic attack 12.65 11.45 54 126048 33685 42461548
Xanthelasma 12.65 11.45 6 126096 89 42495144
Acne 12.64 11.45 13 126089 13631 42481602
Liver function test increased 12.64 11.45 25 126077 19973 42475260
Guillain-Barre syndrome 12.58 11.45 3 126099 7260 42487973
Head injury 12.57 11.45 104 125998 20478 42474755
Sinusitis 12.57 11.45 85 126017 47207 42448026
Hyperphosphataemia 12.50 11.45 12 126090 12992 42482241
Presyncope 12.48 11.45 30 126072 22357 42472876
Hyperacusis 12.47 11.45 15 126087 972 42494261
Bronchitis 12.46 11.45 85 126017 47116 42448117
Diabetic ketoacidosis 12.45 11.45 30 126072 22337 42472896
Toxic encephalopathy 12.41 11.45 47 126055 6906 42488327
Enuresis 12.36 11.45 26 126076 2722 42492511
Panic disorder 12.35 11.45 17 126085 1260 42493973
Product storage error 12.28 11.45 9 126093 11131 42484102
Injection site haemorrhage 12.28 11.45 10 126092 11726 42483507
Antipsychotic drug level above therapeutic 12.27 11.45 17 126085 1267 42493966
Neoplasm malignant 12.27 11.45 31 126071 22712 42472521
Transfusion 12.25 11.45 8 126094 10506 42484727
Disinhibition 12.21 11.45 32 126070 3863 42491370
Haemorrhage intracranial 12.20 11.45 20 126082 17172 42478061
Delirium tremens 12.18 11.45 12 126090 620 42494613
Hernia 12.14 11.45 9 126093 11064 42484169
Subdural haematoma 12.13 11.45 32 126070 23106 42472127
Mesenteric vascular occlusion 12.12 11.45 5 126097 52 42495181
Alcohol withdrawal syndrome 12.10 11.45 18 126084 1433 42493800
Affective disorder 12.09 11.45 42 126060 5918 42489315
Social avoidant behaviour 11.97 11.45 29 126073 3335 42491898
Electrocardiogram T wave amplitude increased 11.97 11.45 6 126096 101 42495132
Blood calcium increased 11.96 11.45 5 126097 8449 42486784
Analgesic drug level above therapeutic 11.94 11.45 9 126093 322 42494911
Herbal interaction 11.93 11.45 10 126092 418 42494815
Respiratory tract infection 11.91 11.45 39 126063 26283 42468950
Hypercalcaemia 11.91 11.45 22 126080 18036 42477197
Compulsions 11.91 11.45 8 126094 238 42494995
Drug screen false positive 11.87 11.45 14 126088 888 42494345
Blood alkaline phosphatase increased 11.86 11.45 55 126047 33542 42461691
Blood ketone body increased 11.86 11.45 11 126091 527 42494706
Hyperthyroidism 11.84 11.45 15 126087 14326 42480907
Foetal distress syndrome 11.79 11.45 16 126086 1170 42494063
Colon cancer 11.78 11.45 7 126095 9674 42485559
Disturbance in social behaviour 11.77 11.45 20 126082 1783 42493450
Device leakage 11.74 11.45 8 126094 10277 42484956
Cerebral ataxia 11.73 11.45 4 126098 23 42495210
Alcohol use 11.72 11.45 26 126076 2822 42492411
Circadian rhythm sleep disorder 11.72 11.45 11 126091 535 42494698
Blood prolactin abnormal 11.67 11.45 15 126087 1040 42494193
Psychomotor retardation 11.67 11.45 34 126068 4365 42490868
Bradycardia neonatal 11.64 11.45 17 126085 1331 42493902
Blood glucose decreased 11.60 11.45 15 126087 14204 42481029
Benzodiazepine drug level therapeutic 11.59 11.45 4 126098 24 42495209
Postural reflex impairment 11.59 11.45 4 126098 24 42495209
Flatulence 11.57 11.45 37 126065 25115 42470118
Blood lactate dehydrogenase increased 11.56 11.45 39 126063 26042 42469191
CSF white blood cell count positive 11.45 11.45 4 126098 25 42495208

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug abuse 9533.67 10.34 5607 249402 171804 110162486
Toxicity to various agents 8190.42 10.34 7582 247427 472973 109861317
Coma 3213.77 10.34 2448 252561 115421 110218869
Completed suicide 3169.30 10.34 3320 251689 239061 110095229
Intentional overdose 2551.36 10.34 2248 252761 130253 110204037
Overdose 2014.51 10.34 2585 252424 231209 110103081
Suicide attempt 1933.45 10.34 1726 253283 101668 110232622
Somnolence 1864.56 10.34 2822 252187 294627 110039663
Drug dependence 1844.23 10.34 1249 253760 48771 110285519
Poisoning 1832.67 10.34 1023 253986 28082 110306208
Drug use disorder 1740.88 10.34 845 254164 17229 110317061
Respiratory arrest 1629.65 10.34 1230 253779 57069 110277221
Poisoning deliberate 1610.29 10.34 908 254101 25423 110308867
Miosis 1606.99 10.34 853 254156 21130 110313160
Substance use disorder 1580.36 10.34 605 254404 6685 110327605
Intentional product misuse 1172.38 10.34 1488 253521 131416 110202874
Depressed level of consciousness 1110.96 10.34 1332 253677 110946 110223344
Agitation 1069.42 10.34 1311 253698 111740 110222550
Cardio-respiratory arrest 1024.83 10.34 1299 253710 114537 110219753
Substance abuse 1012.02 10.34 519 254490 11944 110322346
Respiratory depression 985.67 10.34 716 254293 31285 110303005
Aggression 895.51 10.34 879 254130 58331 110275959
Sopor 890.34 10.34 711 254298 35835 110298455
Intentional self-injury 856.45 10.34 702 254307 36727 110297563
Cardiac arrest 852.66 10.34 1584 253425 195169 110139121
Drug withdrawal syndrome 825.52 10.34 692 254317 37362 110296928
Drug interaction 806.67 10.34 2760 252249 497423 109836867
Bradypnoea 801.69 10.34 394 254615 8255 110326035
Neuroleptic malignant syndrome 754.64 10.34 627 254382 33432 110300858
Suicidal ideation 750.54 10.34 1002 254007 92935 110241355
Altered state of consciousness 686.80 10.34 753 254256 56873 110277417
Mydriasis 586.97 10.34 453 254556 21704 110312586
Schizophrenia 586.44 10.34 450 254559 21376 110312914
Infusion related reaction 558.43 10.34 102 254907 381060 109953230
Psychotic disorder 554.58 10.34 635 254374 50302 110283988
Joint swelling 535.36 10.34 177 254832 442668 109891622
Pneumonia aspiration 533.59 10.34 789 254220 80444 110253846
Synovitis 527.00 10.34 25 254984 274067 110060223
Accidental overdose 501.00 10.34 608 254401 51226 110283064
Withdrawal syndrome 500.91 10.34 480 254529 30900 110303390
Asphyxia 488.28 10.34 340 254669 13875 110320415
Pemphigus 462.77 10.34 6 255003 214564 110119726
Systemic lupus erythematosus 445.08 10.34 38 254971 254300 110079990
Hand deformity 443.78 10.34 13 254996 218493 110115797
Drug intolerance 440.45 10.34 193 254816 406319 109927971
Rheumatoid arthritis 428.50 10.34 85 254924 299528 110034762
Seizure 419.18 10.34 1291 253718 219894 110114396
Pericarditis 414.77 10.34 22 254987 219092 110115198
Arthropathy 412.38 10.34 81 254928 287441 110046849
Sedation 404.25 10.34 639 254370 69044 110265246
Serotonin syndrome 393.40 10.34 578 254431 58575 110275715
Glossodynia 380.80 10.34 36 254973 221968 110112322
Tachycardia 376.93 10.34 1265 253744 225380 110108910
Helicobacter infection 372.36 10.34 10 254999 181867 110152423
Febrile neutropenia 361.50 10.34 139 254870 316628 110017662
Dysarthria 357.40 10.34 672 254337 83449 110250841
Nasopharyngitis 351.87 10.34 239 254770 394122 109940168
Rash 348.74 10.34 870 254139 820094 109514196
Bradyphrenia 346.56 10.34 256 254753 11472 110322818
Arthralgia 340.71 10.34 814 254195 778818 109555472
Folliculitis 340.32 10.34 10 254999 167643 110166647
Diarrhoea 338.46 10.34 1417 253592 1138088 109196202
Duodenal ulcer perforation 335.81 10.34 18 254991 177682 110156608
Contraindicated product administered 335.52 10.34 80 254929 248187 110086103
Stomatitis 322.90 10.34 110 254899 270132 110064158
Restlessness 318.19 10.34 510 254499 55749 110278541
Disturbance in attention 309.05 10.34 531 254478 61464 110272826
Hypothermia 308.63 10.34 341 254668 25961 110308329
Wound 308.16 10.34 80 254929 234357 110099933
Visceral congestion 307.25 10.34 116 254893 1229 110333061
Loss of consciousness 303.03 10.34 1069 253940 195237 110139053
Salivary hypersecretion 298.13 10.34 277 254732 17144 110317146
Swelling 295.80 10.34 226 254783 350815 109983475
Abdominal discomfort 294.82 10.34 284 254725 393574 109940716
Drug abuser 294.47 10.34 173 254836 5236 110329054
Treatment failure 291.74 10.34 137 254872 277097 110057193
Alopecia 287.25 10.34 251 254758 364502 109969788
Impaired healing 287.14 10.34 53 254956 196664 110137626
Peripheral swelling 284.62 10.34 307 254702 403727 109930563
Rheumatoid factor positive 282.41 10.34 4 255005 131636 110202654
Abnormal behaviour 269.05 10.34 388 254621 38651 110295639
Hypersensitivity 268.24 10.34 322 254687 403676 109930614
Disorientation 266.60 10.34 537 254472 70134 110264156
C-reactive protein abnormal 265.95 10.34 7 255002 129688 110204602
Therapeutic product effect decreased 261.30 10.34 118 254891 244198 110090092
Muscle injury 260.71 10.34 16 254993 140791 110193499
General physical health deterioration 258.67 10.34 362 254647 424933 109909357
Hypomania 257.94 10.34 203 254806 10007 110324283
Tremor 251.56 10.34 1028 253981 201204 110133086
Coma scale abnormal 251.38 10.34 196 254813 9530 110324760
Extrapyramidal disorder 250.71 10.34 321 254688 28546 110305744
Psoriatic arthropathy 247.63 10.34 73 254936 196688 110137602
Sinusitis 246.11 10.34 194 254815 296494 110037796
Death 225.68 10.34 2533 252476 696336 109637954
Rhabdomyolysis 223.48 10.34 698 254311 119703 110214587
Fibromyalgia 223.28 10.34 59 254950 170850 110163440
Congenital nystagmus 223.21 10.34 52 254957 62 110334228
Off label use 222.79 10.34 2301 252708 1497884 108836406
Psychomotor hyperactivity 222.70 10.34 254 254755 20023 110314267
Dystonia 222.61 10.34 286 254723 25519 110308771
Drug withdrawal convulsions 222.29 10.34 110 254899 2339 110331951
Sleep disorder due to general medical condition, insomnia type 219.28 10.34 5 255004 105638 110228652
Infection 218.50 10.34 310 254699 361890 109972400
Anaemia 215.76 10.34 601 254408 546485 109787805
Status epilepticus 214.96 10.34 312 254697 31259 110303031
Panic attack 213.27 10.34 297 254712 28643 110305647
Logorrhoea 212.25 10.34 136 254873 4821 110329469
Fatigue 209.43 10.34 1797 253212 1214161 109120129
Discomfort 206.72 10.34 119 254890 214588 110119702
Irritable bowel syndrome 204.67 10.34 62 254947 164153 110170137
Accidental death 203.58 10.34 133 254876 4876 110329414
Inflammation 200.93 10.34 97 254912 193141 110141149
Electrocardiogram QT prolonged 200.67 10.34 630 254379 108330 110225960
Urinary retention 198.56 10.34 473 254536 69210 110265080
Type 2 diabetes mellitus 198.42 10.34 80 254929 177152 110157138
Gastrointestinal disorder 193.43 10.34 164 254845 241788 110092502
Lower respiratory tract infection 191.65 10.34 167 254842 242939 110091351
Muscle rigidity 189.74 10.34 255 254754 23776 110310514
Exposure via ingestion 189.18 10.34 126 254883 4774 110329516
Hypotension 188.11 10.34 1940 253069 521909 109812381
Bursitis 185.33 10.34 37 254972 129881 110204409
Urticaria 182.46 10.34 283 254726 318574 110015716
Akathisia 182.27 10.34 211 254798 16902 110317388
Facet joint syndrome 179.25 10.34 11 254998 96817 110237473
Pruritus 177.76 10.34 714 254295 580846 109753444
Anxiety 176.76 10.34 1381 253628 343697 109990593
Generalised tonic-clonic seizure 176.60 10.34 390 254619 54290 110280000
Joint range of motion decreased 175.25 10.34 34 254975 121798 110212492
Dyspnoea 174.64 10.34 1672 253337 1105200 109229090
Delusion 173.87 10.34 243 254766 23512 110310778
Lip dry 172.17 10.34 16 254993 100067 110234223
Nystagmus 171.46 10.34 170 254839 11407 110322883
Irritability 169.34 10.34 354 254655 47455 110286835
Disease progression 168.88 10.34 188 254821 243846 110090444
Ill-defined disorder 168.85 10.34 75 254934 156778 110177512
Brain oedema 167.78 10.34 276 254733 30822 110303468
Blood creatine phosphokinase increased 166.62 10.34 456 254553 72621 110261669
Pulmonary congestion 164.61 10.34 273 254736 30693 110303597
Breast cancer stage III 163.22 10.34 4 255005 79113 110255177
Jaundice cholestatic 162.14 10.34 184 254825 14424 110319866
Cough 161.98 10.34 535 254474 461106 109873184
Hallucination 161.28 10.34 558 254451 100874 110233416
Pulmonary fibrosis 161.25 10.34 22 254987 102020 110232270
Peripheral venous disease 160.53 10.34 8 255001 84109 110250181
Intentional product use issue 159.79 10.34 202 254807 247704 110086586
COVID-19 159.71 10.34 198 254811 244862 110089428
Housebound 158.94 10.34 54 254955 409 110333881
Dyskinesia 158.38 10.34 360 254649 51086 110283204
Drug detoxification 157.46 10.34 57 254952 531 110333759
Arthritis 156.91 10.34 96 254913 167490 110166800
Asthma 156.12 10.34 209 254800 250082 110084208
Thrombocytopenia 155.41 10.34 360 254649 348525 109985765
Dissociation 154.12 10.34 149 254860 9693 110324597
Mood swings 153.21 10.34 224 254785 22588 110311702
Pulmonary oedema 150.79 10.34 543 254466 100116 110234174
Drug screen positive 150.31 10.34 122 254887 6288 110328002
Speech disorder 150.26 10.34 394 254615 61175 110273115
Pain 148.58 10.34 1447 253562 953508 109380782
Bradykinesia 148.02 10.34 152 254857 10636 110323654
Malignant neoplasm progression 147.42 10.34 112 254897 174455 110159835
Hepatic enzyme increased 147.07 10.34 326 254683 320566 110013724
Respiratory acidosis 146.46 10.34 170 254839 13656 110320634
Drug hypersensitivity 144.75 10.34 548 254461 453542 109880748
Hallucinations, mixed 142.55 10.34 135 254874 8558 110325732
Myelosuppression 138.53 10.34 25 254984 94315 110239975
Therapeutic product effect incomplete 137.43 10.34 189 254820 223616 110110674
Wheezing 137.12 10.34 236 254773 254994 110079296
Emotional disorder 136.09 10.34 177 254832 15983 110318307
Liver injury 134.21 10.34 91 254918 150322 110183968
Arteriosclerosis coronary artery 132.91 10.34 221 254788 24897 110309393
Wound infection 132.41 10.34 30 254979 96435 110237855
Osteoarthritis 129.31 10.34 138 254871 182485 110151805
Behaviour disorder 128.90 10.34 134 254875 9513 110324777
Unresponsive to stimuli 128.81 10.34 381 254628 63409 110270881
Cholelithiasis 127.30 10.34 378 254631 63044 110271246
Drug ineffective 126.78 10.34 2612 252397 1517928 108816362
Hyperhidrosis 125.93 10.34 801 254208 186497 110147793
Pyrexia 125.79 10.34 1395 253614 896870 109437420
Abdominal pain upper 124.88 10.34 401 254608 348710 109985580
Alcohol abuse 124.51 10.34 98 254911 4831 110329459
Blood cholesterol increased 123.88 10.34 146 254863 184639 110149651
Mania 123.74 10.34 193 254816 20603 110313687
Hallucination, auditory 123.60 10.34 220 254789 26177 110308113
Chemical submission 121.63 10.34 47 254962 533 110333757
Sudden death 121.61 10.34 209 254800 24186 110310104
Sinus tachycardia 121.36 10.34 297 254712 44196 110290094
Ataxia 121.02 10.34 235 254774 29873 110304417
Grip strength decreased 120.45 10.34 20 254989 80154 110254136
Total lung capacity increased 119.24 10.34 97 254912 5015 110329275
Blister 118.73 10.34 214 254795 227162 110107128
Paranoia 117.24 10.34 196 254813 22178 110312112
Live birth 117.17 10.34 12 254997 69472 110264818
Anger 116.74 10.34 179 254830 18828 110315462
Nightmare 115.26 10.34 268 254741 38595 110295695
Prescription drug used without a prescription 115.14 10.34 98 254911 5398 110328892
Mucosal inflammation 114.99 10.34 39 254970 96102 110238188
Product use issue 114.30 10.34 354 254655 311341 110022949
Lung disorder 113.62 10.34 149 254860 179898 110154392
Developmental delay 113.14 10.34 59 254950 1406 110332884
Interstitial lung disease 111.86 10.34 94 254915 139240 110195050
Parkinsonism 111.80 10.34 191 254818 21996 110312294
Catatonia 111.51 10.34 134 254875 11166 110323124
Accidental poisoning 110.88 10.34 70 254939 2417 110331873
Colitis ulcerative 110.40 10.34 22 254987 77341 110256949
Oedema 110.19 10.34 197 254812 209779 110124511
Myoglobin urine present 110.12 10.34 50 254959 870 110333420
Pancytopenia 109.70 10.34 197 254812 209416 110124874
Aspiration 109.20 10.34 227 254782 30306 110303984
Psychomotor skills impaired 108.91 10.34 106 254903 6952 110327338
Alcohol interaction 107.72 10.34 80 254929 3614 110330676
Alcohol poisoning 107.64 10.34 118 254891 8902 110325388
Self-injurious ideation 106.76 10.34 85 254924 4261 110330029
Liver disorder 105.80 10.34 103 254906 142140 110192150
Musculoskeletal pain 105.05 10.34 162 254847 182861 110151429
Asthma-chronic obstructive pulmonary disease overlap syndrome 104.94 10.34 99 254910 6245 110328045
Victim of crime 104.81 10.34 55 254954 1328 110332962
Frequent bowel movements 104.64 10.34 19 254990 71371 110262919
Abdominal pain 103.88 10.34 724 254285 512265 109822025
Autoimmune disorder 103.74 10.34 14 254995 65469 110268821
Sciatica 102.92 10.34 42 254967 92357 110241933
Mobility decreased 102.47 10.34 249 254760 237173 110097117
Gastric pH decreased 101.69 10.34 49 254960 981 110333309
Vital capacity decreased 101.67 10.34 62 254947 2011 110332279
Hypotonia 100.55 10.34 151 254858 15594 110318696
Strabismus congenital 100.34 10.34 23 254986 24 110334266
Bradycardia 100.17 10.34 658 254351 154859 110179431
Psychotic symptom 100.09 10.34 78 254931 3789 110330501
Agoraphobia 98.83 10.34 43 254966 673 110333617
Depersonalisation/derealisation disorder 98.77 10.34 62 254947 2119 110332171
Delirium 98.63 10.34 590 254419 134435 110199855
Night sweats 98.51 10.34 98 254911 133885 110200405
Hypercholesterolaemia 98.43 10.34 43 254966 90794 110243496
Suicidal behaviour 98.11 10.34 74 254935 3423 110330867
Dependence 97.77 10.34 67 254942 2662 110331628
Drooling 96.89 10.34 100 254909 7039 110327251
Derealisation 96.86 10.34 61 254948 2097 110332193
Reversible airways obstruction 95.85 10.34 64 254945 2435 110331855
Hypertonia 93.49 10.34 106 254903 8300 110325990
Confusional state 93.41 10.34 1559 253450 467121 109867169
Dyspnoea exertional 92.76 10.34 63 254946 103997 110230293
Sedation complication 92.34 10.34 165 254844 19690 110314600
Mental impairment 91.35 10.34 177 254832 22462 110311828
Taste disorder 90.41 10.34 20 254989 65367 110268923
Victim of chemical submission 90.38 10.34 43 254966 836 110333454
Nail disorder 90.33 10.34 13 254996 57922 110276368
Injection site pain 89.73 10.34 171 254838 177751 110156539
Onychomadesis 88.23 10.34 4 255005 45659 110288631
Cogwheel rigidity 88.01 10.34 71 254938 3627 110330663
Cytomegalovirus infection 87.79 10.34 11 254998 54433 110279857
Pain in extremity 86.98 10.34 712 254297 486406 109847884
Depressed mood 86.81 10.34 323 254686 60486 110273804
Hypoventilation 86.67 10.34 100 254909 7981 110326309
Thinking abnormal 86.61 10.34 138 254871 15002 110319288
C-reactive protein increased 86.03 10.34 239 254770 217680 110116610
Lower limb fracture 85.97 10.34 33 254976 75315 110258975
Cyanosis 85.91 10.34 203 254806 29538 110304752
Loss of personal independence in daily activities 84.94 10.34 134 254875 149886 110184404
Maternal exposure during pregnancy 84.81 10.34 302 254707 254581 110079709
Feeling of despair 84.26 10.34 70 254939 3728 110330562
Product use in unapproved indication 84.00 10.34 645 254364 446732 109887558
Mental disorder 83.42 10.34 237 254772 38554 110295736
Inappropriate schedule of product administration 82.89 10.34 220 254789 203417 110130873
Liver function test increased 82.48 10.34 51 254958 88497 110245793
Hallucination, visual 82.29 10.34 239 254770 39366 110294924
Sepsis 81.95 10.34 432 254577 326914 110007376
Atrial fibrillation 81.92 10.34 264 254745 229378 110104912
Red blood cell sedimentation rate increased 81.83 10.34 39 254970 78263 110256027
Hyperthermia 81.82 10.34 163 254846 21109 110313181
Neutropenia 80.65 10.34 519 254490 374101 109960189
Substance abuser 80.34 10.34 33 254976 444 110333846
Knee arthroplasty 80.04 10.34 25 254984 64923 110269367
Antipsychotic drug level increased 78.94 10.34 89 254920 6926 110327364
Haematochezia 78.79 10.34 90 254919 115434 110218856
Sleep disorder due to a general medical condition 78.28 10.34 13 254996 52099 110282191
Snoring 77.93 10.34 87 254922 6697 110327593
Weight increased 77.84 10.34 607 254402 419037 109915253
Psoriasis 77.41 10.34 127 254882 139866 110194424
Platelet count decreased 77.36 10.34 272 254737 230171 110104119
Lethargy 76.92 10.34 422 254587 93154 110241136
Sputum culture positive 76.72 10.34 67 254942 3822 110330468
Psychomotor retardation 76.23 10.34 92 254917 7700 110326590
Psychotic behaviour 76.06 10.34 45 254964 1380 110332910
Bladder dilatation 76.04 10.34 55 254954 2384 110331906
Depression 75.96 10.34 1089 253920 316246 110018044
Drug level increased 75.38 10.34 262 254747 47457 110286833
Coeliac disease 74.02 10.34 7 255002 43180 110291110
Adverse event 73.95 10.34 85 254924 108724 110225566
Balance disorder 73.73 10.34 491 254518 116069 110218221
Cognitive disorder 73.52 10.34 397 254612 87114 110247176
Dyspepsia 73.48 10.34 212 254797 190753 110143537
Hip arthroplasty 73.38 10.34 19 254990 55794 110278496
Potentiating drug interaction 71.99 10.34 110 254899 11533 110322757
Cytokine release syndrome 71.98 10.34 36 254973 70270 110264020
Toxicologic test abnormal 71.66 10.34 42 254967 1265 110333025
Lupus-like syndrome 71.57 10.34 6 255003 40786 110293504
Persecutory delusion 71.11 10.34 80 254929 6211 110328079
Rectal haemorrhage 70.76 10.34 104 254905 119729 110214561
Electroencephalogram abnormal 70.63 10.34 79 254930 6094 110328196
Strabismus 70.47 10.34 61 254948 3438 110330852
Adjustment disorder with depressed mood 70.43 10.34 9 255000 43874 110290416
Self-medication 70.02 10.34 79 254930 6153 110328137
Erythema 69.97 10.34 390 254619 291057 110043233
Haemoglobin decreased 69.31 10.34 316 254693 248411 110085879
Feeling of body temperature change 68.77 10.34 78 254931 6110 110328180
Gastrointestinal haemorrhage 68.74 10.34 177 254832 165341 110168949
Asthenia 68.45 10.34 1147 253862 687852 109646438
Blood pressure fluctuation 68.45 10.34 44 254965 74780 110259510
Toxic encephalopathy 67.66 10.34 124 254885 15090 110319200
Musculoskeletal stiffness 67.42 10.34 374 254635 279448 110054842
Colitis 67.33 10.34 82 254927 102241 110232049
Gait inability 67.08 10.34 133 254876 136243 110198047
Tearfulness 67.00 10.34 84 254925 7311 110326979
Hypoxic-ischaemic encephalopathy 66.98 10.34 92 254917 8755 110325535
Tension 66.88 10.34 70 254939 5008 110329282
Product dose omission issue 66.12 10.34 452 254557 321330 110012960
Injection site reaction 64.50 10.34 66 254943 89004 110245286
Decreased appetite 64.44 10.34 744 254265 475102 109859188
Stiff person syndrome 63.96 10.34 31 254978 629 110333661
Obesity 63.45 10.34 102 254907 113249 110221041
Incontinence 63.42 10.34 127 254882 16508 110317782
Blood pressure systolic increased 62.98 10.34 59 254950 82932 110251358
Fluid retention 62.66 10.34 75 254934 94232 110240058
Acute kidney injury 61.74 10.34 1062 253947 634368 109699922
H1N1 influenza 61.57 10.34 53 254956 2965 110331325
Physical assault 60.78 10.34 41 254968 1587 110332703
Bronchial secretion retention 60.43 10.34 66 254943 4958 110329332
Ascites 60.41 10.34 75 254934 92733 110241557
Drug-induced liver injury 60.00 10.34 116 254893 119951 110214339
Drowning 59.79 10.34 33 254976 884 110333406
Condition aggravated 59.78 10.34 1266 253743 733570 109600720
Contusion 59.49 10.34 306 254703 233055 110101235
Autonomic nervous system imbalance 59.44 10.34 70 254939 5710 110328580
Herpes zoster 59.28 10.34 99 254910 108280 110226010
Nausea 59.08 10.34 2292 252717 1233398 109100892
Brain injury 58.88 10.34 109 254900 13367 110320923
Weight decreased 57.99 10.34 746 254263 467311 109866979
Cardiac failure congestive 57.82 10.34 168 254841 150832 110183458
Finger deformity 57.69 10.34 5 255004 33087 110301203
Pleural effusion 56.83 10.34 214 254795 177495 110156795
Pyramidal tract syndrome 56.66 10.34 31 254978 816 110333474
Productive cough 56.63 10.34 111 254898 114194 110220096
Autonomic dysreflexia 56.21 10.34 26 254983 473 110333817
Cardiomegaly 55.98 10.34 171 254838 28959 110305331
Patient uncooperative 55.69 10.34 32 254977 928 110333362
Urinary incontinence 55.67 10.34 241 254768 48346 110285944
Social anxiety disorder 55.51 10.34 32 254977 934 110333356
Pneumocystis jirovecii pneumonia 55.32 10.34 15 254994 42720 110291570
Sarcoidosis 55.28 10.34 102 254907 12477 110321813
Neoplasm progression 55.08 10.34 41 254968 64554 110269736
Onychomycosis 54.88 10.34 11 254998 38520 110295770
Choking 54.81 10.34 113 254896 14997 110319293
Incoherent 54.58 10.34 81 254928 8277 110326013
Hypertension 54.32 10.34 838 254171 509246 109825044
Victim of sexual abuse 54.30 10.34 26 254983 513 110333777
Optic nerve hypoplasia 54.20 10.34 12 254997 9 110334281
Electrocardiogram QRS complex prolonged 54.00 10.34 103 254906 12918 110321372
Restless legs syndrome 53.48 10.34 151 254858 24475 110309815
Bone marrow failure 52.94 10.34 34 254975 57814 110276476
Stupor 52.40 10.34 79 254930 8186 110326104
Schizoaffective disorder 51.99 10.34 49 254960 3087 110331203
Drug withdrawal maintenance therapy 51.91 10.34 18 254991 146 110334144
Nasal polyps 51.80 10.34 102 254907 13098 110321192
Abnormal dreams 51.66 10.34 100 254909 12680 110321610
Headache 51.49 10.34 1596 253413 880781 109453509
Drug tolerance decreased 51.35 10.34 3 255006 27537 110306753
Euphoric mood 51.24 10.34 81 254928 8746 110325544
Hepatocellular injury 51.15 10.34 242 254767 50400 110283890
Joint stiffness 50.80 10.34 48 254961 67195 110267095
Echolalia 50.76 10.34 25 254984 526 110333764
Alcoholism 50.44 10.34 52 254957 3655 110330635
Drug diversion 49.72 10.34 34 254975 1346 110332944
Foot deformity 49.36 10.34 25 254984 48455 110285835
Sinus bradycardia 49.30 10.34 165 254844 29318 110304972
Hyperprolactinaemia 49.22 10.34 68 254941 6507 110327783
Myocarditis 49.20 10.34 167 254842 29888 110304402
Treatment noncompliance 48.92 10.34 312 254697 72678 110261612
Cytopenia 48.76 10.34 6 255003 30110 110304180
Blood pressure increased 48.68 10.34 372 254637 258001 110076289
Acute myeloid leukaemia 48.17 10.34 14 254995 38096 110296194
Cryopyrin associated periodic syndrome 47.78 10.34 25 254984 600 110333690
Menstrual disorder 47.65 10.34 57 254952 4727 110329563
Therapeutic response decreased 47.55 10.34 94 254915 96405 110237885
Neuropathy peripheral 47.44 10.34 232 254777 179045 110155245
Nasal congestion 47.35 10.34 97 254912 98185 110236105
Osteoporosis 47.31 10.34 80 254929 87072 110247218
Fear 47.26 10.34 139 254870 23054 110311236
Postmortem blood drug level abnormal 47.22 10.34 25 254984 615 110333675
Rhinitis allergic 47.14 10.34 118 254891 17804 110316486
Multiple sclerosis relapse 47.09 10.34 235 254774 50005 110284285
Hepatic cytolysis 47.08 10.34 251 254758 54802 110279488
Myocardial fibrosis 46.84 10.34 38 254971 1957 110332333
Hypervolaemia 46.74 10.34 28 254981 49432 110284858
Vision blurred 46.70 10.34 479 254530 128543 110205747
Antipsychotic drug level decreased 46.69 10.34 33 254976 1379 110332911
Basal cell carcinoma 46.61 10.34 23 254986 45247 110289043
Cardiac murmur 45.86 10.34 143 254866 24485 110309805
Neurosis 45.49 10.34 24 254985 586 110333704
Blepharospasm 45.26 10.34 36 254973 54815 110279475
Tardive dyskinesia 45.14 10.34 98 254911 13481 110320809
Congenital visual acuity reduced 44.89 10.34 10 254999 8 110334282
Injury 44.85 10.34 233 254776 177032 110157258
Upper respiratory tract infection 44.74 10.34 154 254855 131174 110203116
Anterograde amnesia 44.69 10.34 27 254982 861 110333429
Tubulointerstitial nephritis 44.33 10.34 36 254973 54248 110280042
Spleen congestion 44.07 10.34 22 254987 477 110333813
Muscle disorder 44.05 10.34 65 254944 6607 110327683
Rash pruritic 43.76 10.34 101 254908 97968 110236322
Myelodysplastic syndrome 43.46 10.34 16 254993 37468 110296822
Exostosis 43.45 10.34 26 254983 45930 110288360
Vestibular disorder 43.40 10.34 41 254968 2591 110331699
Generalised anxiety disorder 43.38 10.34 42 254967 2737 110331553
Faecaloma 43.32 10.34 102 254907 14806 110319484
Opiates positive 43.30 10.34 27 254982 912 110333378
Psychogenic seizure 43.20 10.34 39 254970 2325 110331965
Bezoar 43.19 10.34 50 254959 4004 110330286
Oropharyngeal pain 43.18 10.34 163 254846 135113 110199177
Skin ulcer 42.94 10.34 50 254959 63595 110270695
Respiratory rate decreased 42.82 10.34 62 254947 6196 110328094
Blood pressure systolic abnormal 42.66 10.34 4 255005 24846 110309444
Acute psychosis 42.58 10.34 55 254954 4932 110329358
Alcohol use 42.52 10.34 50 254959 4072 110330218
Epistaxis 42.33 10.34 156 254853 130216 110204074
Blood pH decreased 42.25 10.34 53 254956 4616 110329674
Blood pressure diastolic abnormal 42.15 10.34 5 255004 25810 110308480
Injection site erythema 42.02 10.34 97 254912 94079 110240211
Sluggishness 41.95 10.34 68 254941 7499 110326791
Therapeutic product ineffective 41.86 10.34 40 254969 2564 110331726
Hypokinesia 41.82 10.34 128 254881 21698 110312592
Homicide 41.64 10.34 28 254981 1078 110333212
Pneumonia 41.39 10.34 1628 253381 875086 109459204
Seizure cluster 41.08 10.34 25 254984 808 110333482
Circulatory collapse 40.93 10.34 202 254807 42791 110291499
Social avoidant behaviour 40.90 10.34 56 254953 5313 110328977
PCO2 increased 40.90 10.34 35 254974 1942 110332348
Persistent depressive disorder 40.87 10.34 31 254978 1446 110332844
Emotional distress 40.79 10.34 208 254801 44639 110289651
Hypercapnic coma 40.51 10.34 21 254988 494 110333796
Prostate cancer 40.49 10.34 18 254991 37623 110296667
Paralysis 40.29 10.34 102 254907 15498 110318792
Adverse drug reaction 40.00 10.34 118 254891 105441 110228849
Myoclonus 39.60 10.34 166 254843 32832 110301458
Transplant rejection 39.52 10.34 5 255004 24562 110309728
Mutism 39.38 10.34 42 254967 3071 110331219
Substance use 39.35 10.34 38 254971 2468 110331822
Oromandibular dystonia 39.18 10.34 28 254981 1191 110333099
Hypersomnia 39.17 10.34 148 254861 27913 110306377
Mucosal erosion 39.12 10.34 40 254969 2784 110331506
Pneumonitis 39.06 10.34 73 254936 76458 110257832
Drug withdrawal syndrome neonatal 38.94 10.34 18 254991 327 110333963
Malaise 38.93 10.34 1216 253793 670603 109663687
Pancreatic fibrosis 38.78 10.34 13 254996 94 110334196
Nervousness 38.61 10.34 178 254831 36673 110297617
Feeling jittery 37.75 10.34 96 254913 14626 110319664
Apathy 37.67 10.34 102 254907 16137 110318153
Microcephaly 37.26 10.34 15 254994 191 110334099
Inadequate analgesia 37.25 10.34 52 254957 5025 110329265
Back injury 36.79 10.34 33 254976 47366 110286924
Hepatic cirrhosis 36.77 10.34 62 254947 67564 110266726
Acidosis 36.71 10.34 125 254884 22406 110311884
Head injury 36.70 10.34 196 254813 42821 110291469
Immobilisation prolonged 36.53 10.34 14 254995 155 110334135
Crying 36.46 10.34 136 254873 25492 110308798
Illusion 36.45 10.34 33 254976 1974 110332316
Metastases to liver 36.40 10.34 18 254991 35368 110298922
Palmar-plantar erythrodysaesthesia syndrome 36.34 10.34 25 254984 41000 110293290
Blood alcohol increased 36.31 10.34 25 254984 1001 110333289
Blood prolactin increased 36.25 10.34 49 254960 4593 110329697
Dry mouth 36.20 10.34 291 254718 199657 110134633
Device expulsion 36.13 10.34 13 254996 30878 110303412
Penis injury 36.11 10.34 13 254996 119 110334171
Injection site swelling 36.11 10.34 54 254955 61736 110272554
Nodule 36.06 10.34 15 254994 32616 110301674
Bacteraemia 36.02 10.34 27 254982 42363 110291927
Electrocardiogram J wave 36.01 10.34 12 254997 85 110334205
Influenza 35.98 10.34 235 254774 168866 110165424
Therapy interrupted 35.98 10.34 37 254972 49785 110284505
Rhinorrhoea 35.91 10.34 119 254890 102547 110231743
Blood potassium increased 35.88 10.34 162 254847 33087 110301203
Homicidal ideation 35.77 10.34 43 254966 3584 110330706
Hypoaesthesia 35.57 10.34 510 254499 313713 110020577
Conversion disorder 35.46 10.34 35 254974 2335 110331955
Multiple sclerosis 35.43 10.34 135 254874 25563 110308727
Poor quality sleep 35.07 10.34 143 254866 27934 110306356
Bronchitis 35.07 10.34 215 254794 156817 110177473
Encephalitis toxic 35.05 10.34 16 254993 282 110334008
Apnoea 35.04 10.34 89 254920 13550 110320740
Laryngitis 34.79 10.34 28 254981 42383 110291907
Torticollis 34.78 10.34 40 254969 3181 110331109
Postmortem blood drug level increased 34.69 10.34 26 254983 1191 110333099
Thrombotic microangiopathy 34.55 10.34 12 254997 29137 110305153
Creatinine renal clearance increased 34.16 10.34 42 254967 3583 110330707
Necrotising colitis 34.00 10.34 30 254979 1735 110332555
Oedema peripheral 33.92 10.34 543 254466 328117 110006173
Injection site pruritus 33.80 10.34 41 254968 51217 110283073
Cortisol increased 33.78 10.34 20 254989 614 110333676
Cataract 33.77 10.34 84 254925 79401 110254889
Premature labour 33.75 10.34 69 254940 9103 110325187
Diabetes insipidus 33.68 10.34 57 254952 6513 110327777
Hepatotoxicity 33.64 10.34 256 254753 63144 110271146
Myoclonic epilepsy 33.50 10.34 36 254973 2655 110331635
Ulcer 33.49 10.34 30 254979 43086 110291204
Cardiopulmonary failure 33.37 10.34 63 254946 7840 110326450
Theft 33.30 10.34 15 254994 256 110334034
Hanging 33.27 10.34 14 254995 201 110334089
PO2 increased 33.07 10.34 28 254981 1531 110332759
Amimia 33.00 10.34 11 254998 78 110334212
Blood pressure diastolic decreased 32.96 10.34 21 254988 35864 110298426
Transfusion 32.86 10.34 9 255000 25463 110308827
Tumour lysis syndrome 32.71 10.34 15 254994 30786 110303504
Multiple-drug resistance 32.59 10.34 85 254924 13150 110321140
Amylase increased 32.48 10.34 82 254927 12437 110321853
Panic disorder 32.46 10.34 40 254969 3421 110330869
Renal impairment 32.41 10.34 278 254731 188167 110146123
Major depression 32.32 10.34 74 254935 10547 110323743
Encephalopathy 32.28 10.34 307 254702 80748 110253542
Sputum discoloured 32.27 10.34 12 254997 27933 110306357
Haematotoxicity 32.25 10.34 5 255004 21077 110313213
Epstein-Barr virus infection 32.21 10.34 3 255006 18735 110315555
Maternal exposure timing unspecified 32.10 10.34 5 255004 21008 110313282
Somnambulism 32.09 10.34 55 254954 6350 110327940
Hallucination, tactile 31.90 10.34 23 254986 992 110333298
Hospitalisation 31.87 10.34 195 254814 142298 110191992
Muscular weakness 31.86 10.34 393 254616 248075 110086215
Hepatic steatosis 31.66 10.34 207 254802 48624 110285666
Multiple drug therapy 31.53 10.34 62 254947 7952 110326338
Somatic delusion 31.41 10.34 20 254989 701 110333589
Sensory disturbance 31.35 10.34 100 254909 17329 110316961
Benzodiazepine drug level increased 31.34 10.34 14 254995 234 110334056
Aspergillus infection 31.31 10.34 10 254999 25606 110308684
Delusion of reference 30.97 10.34 14 254995 241 110334049
Thrombosis 30.88 10.34 137 254872 108525 110225765
Personality change 30.59 10.34 74 254935 10928 110323362
Neutrophil count decreased 30.57 10.34 159 254850 120782 110213508
Chest discomfort 30.56 10.34 255 254754 173593 110160697
White blood cell count decreased 30.48 10.34 360 254649 229030 110105260
Dry skin 30.43 10.34 136 254873 107517 110226773
Andropause 30.24 10.34 11 254998 104 110334186
Dysphagia 30.17 10.34 510 254499 153090 110181200
Enuresis 30.12 10.34 42 254967 4054 110330236
Pulmonary toxicity 30.08 10.34 3 255006 17743 110316547
Osteonecrosis of jaw 30.01 10.34 40 254969 47977 110286313
Cardiac failure 29.99 10.34 282 254727 187344 110146946
Hostility 29.99 10.34 34 254975 2662 110331628
Fatty liver alcoholic 29.98 10.34 9 255000 43 110334247
Feeling drunk 29.91 10.34 49 254960 5451 110328839
Drug screen false positive 29.89 10.34 25 254984 1344 110332946
COVID-19 pneumonia 29.87 10.34 25 254984 37118 110297172
Opisthotonus 29.83 10.34 20 254989 766 110333524
Hyperaesthesia 29.76 10.34 88 254921 14639 110319651
Bronchopulmonary aspergillosis 29.52 10.34 16 254993 29847 110304443
Paradoxical drug reaction 29.44 10.34 68 254941 9749 110324541
Ear infection 29.30 10.34 63 254946 62669 110271621
Clinomania 29.18 10.34 10 254999 78 110334212
Hyperacusis 29.12 10.34 35 254974 2917 110331373
Partial seizures 29.09 10.34 74 254935 11275 110323015
Electrocardiogram QRS complex shortened 29.07 10.34 20 254989 800 110333490
Disinhibition 29.04 10.34 36 254973 3098 110331192
Immunodeficiency 29.01 10.34 28 254981 38810 110295480
Haemodynamic instability 28.93 10.34 117 254892 22771 110311519
Adrenal insufficiency 28.92 10.34 33 254976 42357 110291933
Hyperreflexia 28.77 10.34 66 254943 9419 110324871
Blood creatinine increased 28.76 10.34 276 254733 182613 110151677
Accident 28.69 10.34 72 254937 10880 110323410
Pulmonary valve incompetence 28.40 10.34 33 254976 2653 110331637
Pupillary disorder 28.22 10.34 18 254991 633 110333657
Clostridium difficile infection 28.15 10.34 48 254961 52081 110282209
Muscle twitching 28.04 10.34 140 254869 29795 110304495
Anaphylactic reaction 27.93 10.34 152 254857 114148 110220142
Anti factor V antibody 27.86 10.34 14 254995 308 110333982
Erectile dysfunction 27.69 10.34 100 254909 18456 110315834
Prescribed overdose 27.64 10.34 106 254903 87475 110246815
Delusional disorder, unspecified type 27.57 10.34 20 254989 871 110333419
Patient restraint 27.55 10.34 10 254999 94 110334196
Therapy non-responder 27.53 10.34 231 254778 157076 110177214
Product quality issue 27.45 10.34 89 254920 77210 110257080
International normalised ratio increased 27.40 10.34 105 254904 86667 110247623
Uveitis 27.39 10.34 8 255001 21702 110312588
Coordination abnormal 27.28 10.34 123 254886 25105 110309185
Leukopenia 27.18 10.34 216 254793 148575 110185715
Trismus 27.14 10.34 52 254957 6544 110327746
Sexual abuse 27.04 10.34 13 254996 259 110334031
Neutrophil count increased 26.96 10.34 154 254855 34498 110299792
Petit mal epilepsy 26.85 10.34 56 254953 7491 110326799
Postictal psychosis 26.81 10.34 13 254996 264 110334026
Multiple allergies 26.44 10.34 75 254934 12188 110322102
Oral discharge 26.42 10.34 13 254996 273 110334017
Impaired reasoning 26.40 10.34 10 254999 107 110334183
Plasma cell myeloma 26.35 10.34 67 254942 62869 110271421
Daydreaming 26.35 10.34 22 254987 1180 110333110
Dry eye 26.09 10.34 56 254953 55737 110278553
Melaena 25.95 10.34 77 254932 68680 110265610
Mononeuropathy 25.92 10.34 14 254995 359 110333931
Haemophagocytic lymphohistiocytosis 25.68 10.34 21 254988 31538 110302752
Dyspraxia 25.42 10.34 13 254996 297 110333993
Anticonvulsant drug level above therapeutic 25.41 10.34 22 254987 1240 110333050
Pleurothotonus 25.27 10.34 30 254979 2468 110331822
Pathogen resistance 25.26 10.34 5 255004 17667 110316623
Priapism 25.10 10.34 47 254962 5814 110328476
Rhesus antigen positive 25.08 10.34 10 254999 124 110334166
Congestive hepatopathy 25.07 10.34 44 254965 5176 110329114
Respiratory distress 25.06 10.34 256 254753 68618 110265672
Troponin increased 24.97 10.34 135 254874 29631 110304659
Adverse reaction 24.95 10.34 19 254990 29575 110304715
Staring 24.86 10.34 32 254977 2860 110331430
Febrile bone marrow aplasia 24.84 10.34 5 255004 17460 110316830
Aphasia 24.77 10.34 226 254783 58771 110275519
Angioedema 24.61 10.34 130 254879 98370 110235920
Calcium deficiency 24.61 10.34 21 254988 1161 110333129
Hypovitaminosis 24.56 10.34 23 254986 1437 110332853
Gas poisoning 24.48 10.34 9 255000 88 110334202
Judgement impaired 24.42 10.34 22 254987 1308 110332982
Long QT syndrome 24.38 10.34 52 254957 7066 110327224
Terminal dribbling 24.22 10.34 6 255003 11 110334279
Drug level above therapeutic 24.14 10.34 70 254939 11518 110322772
Substance dependence 24.10 10.34 17 254992 708 110333582
Pregnancy 24.09 10.34 51 254958 51016 110283274
Arrhythmia 24.08 10.34 256 254753 69319 110264971
Food allergy 24.01 10.34 8 255001 19940 110314350
Hyperkalaemia 23.95 10.34 199 254810 135597 110198693
Alcohol withdrawal syndrome 23.93 10.34 27 254982 2103 110332187
Clostridium difficile colitis 23.93 10.34 40 254969 43738 110290552
Polyarthritis 23.91 10.34 7 255002 18956 110315334
Cerebellar syndrome 23.89 10.34 48 254961 6254 110328036
Sinus congestion 23.89 10.34 21 254988 30438 110303852
Body temperature decreased 23.87 10.34 30 254979 36905 110297385
Localised infection 23.84 10.34 39 254970 43009 110291281
Blood bilirubin increased 23.76 10.34 274 254735 75698 110258592
Fungal infection 23.75 10.34 51 254958 50755 110283535
Migraine 23.73 10.34 267 254742 171385 110162905
Pulmonary arterial hypertension 23.73 10.34 24 254985 32544 110301746
Borderline personality disorder 23.65 10.34 20 254989 1092 110333198
Gastrointestinal motility disorder 23.60 10.34 52 254957 7224 110327066
Clonus 23.57 10.34 58 254951 8658 110325632
Hepatitis 23.55 10.34 117 254892 89937 110244353
Bundle branch block right 23.47 10.34 72 254937 12219 110322071
Tuberculosis 23.46 10.34 6 255003 17768 110316522
Ductus arteriosus premature closure 23.46 10.34 9 255000 100 110334190
Cellulitis 23.45 10.34 182 254827 125834 110208456
Slow speech 23.36 10.34 34 254975 3414 110330876
Drug dose omission by device 23.24 10.34 3 255006 14513 110319777
Toxic epidermal necrolysis 23.16 10.34 216 254793 56511 110277779
Behavioural addiction 23.06 10.34 8 255001 65 110334225
Chronic kidney disease 23.02 10.34 94 254915 76197 110258093
Eosinophil count decreased 23.01 10.34 46 254963 5972 110328318
Impulsive behaviour 22.91 10.34 33 254976 3282 110331008
Upper gastrointestinal haemorrhage 22.83 10.34 51 254958 50045 110284245
Swollen tongue 22.75 10.34 226 254783 60136 110274154
Chills 22.74 10.34 306 254703 190274 110144016
Injection site warmth 22.73 10.34 6 255003 17399 110316891
Emotional poverty 22.72 10.34 19 254990 1021 110333269
Marchiafava-Bignami disease 22.69 10.34 6 255003 16 110334274
Somatic symptom disorder 22.65 10.34 32 254977 3127 110331163
Reflexes abnormal 22.61 10.34 19 254990 1028 110333262
Chronic sinusitis 22.60 10.34 15 254994 25069 110309221
Septic shock 22.58 10.34 243 254766 157285 110177005
Drug eruption 22.56 10.34 57 254952 53602 110280688
Affective disorder 22.55 10.34 67 254942 11174 110323116
Bacterial infection 22.54 10.34 45 254964 45991 110288299
Sputum culture 22.42 10.34 12 254997 302 110333988
Refusal of treatment by patient 22.39 10.34 60 254949 9434 110324856
Feeling hot 22.34 10.34 121 254888 90985 110243305
Drug tolerance increased 22.20 10.34 15 254994 582 110333708
Coloboma 22.17 10.34 6 255003 18 110334272
Portal tract inflammation 22.14 10.34 11 254998 236 110334054
Poverty of speech 22.11 10.34 15 254994 586 110333704
Wrong rate 22.08 10.34 10 254999 173 110334117
Skin necrosis 22.04 10.34 11 254998 21501 110312789
Flat affect 21.97 10.34 28 254981 2477 110331813
Eye pruritus 21.84 10.34 26 254983 32749 110301541
Proctitis 21.80 10.34 6 255003 16921 110317369
Ileus paralytic 21.72 10.34 68 254941 11669 110322621
Diffuse large B-cell lymphoma 21.70 10.34 5 255004 15893 110318397
Abdominal distension 21.67 10.34 279 254730 174824 110159466
Fear of disease 21.62 10.34 21 254988 1374 110332916
Back pain 21.57 10.34 671 254338 370325 109963965
Muscle tightness 21.56 10.34 79 254930 14683 110319607
Myositis 21.47 10.34 24 254985 31092 110303198
Right ventricular failure 21.46 10.34 17 254992 25937 110308353
Infusion site reaction 21.44 10.34 7 255002 17675 110316615
Diet refusal 21.44 10.34 17 254992 847 110333443
Kidney congestion 21.39 10.34 14 254995 515 110333775
Pustular psoriasis 21.33 10.34 3 255006 13602 110320688
Alpha 1 microglobulin increased 21.33 10.34 7 255002 47 110334243
Delirium tremens 21.31 10.34 16 254993 735 110333555
Basal ganglion degeneration 21.28 10.34 13 254996 423 110333867
Walking aid user 21.27 10.34 16 254993 25059 110309231
Galactorrhoea 21.24 10.34 36 254973 4119 110330171
Clonic convulsion 21.20 10.34 22 254987 1558 110332732
Intestinal pseudo-obstruction 21.16 10.34 32 254977 3324 110330966
Left ventricular hypertrophy 21.16 10.34 73 254936 13171 110321119
Flashback 21.12 10.34 13 254996 429 110333861
Respiratory tract congestion 21.08 10.34 24 254985 30833 110303457
Panniculitis 21.07 10.34 5 255004 15577 110318713
Cardiac arrest neonatal 21.05 10.34 6 255003 23 110334267
Gallbladder cholesterolosis 21.03 10.34 15 254994 636 110333654
Female genital tract fistula 21.00 10.34 6 255003 16513 110317777
Alcoholic coma 21.00 10.34 8 255001 87 110334203
Needle track marks 21.00 10.34 8 255001 87 110334203
Joint effusion 20.96 10.34 11 254998 20894 110313396
Hyperchloraemia 20.88 10.34 20 254989 1286 110333004
Obsessive thoughts 20.87 10.34 20 254989 1287 110333003
Wrong patient received product 20.87 10.34 47 254962 6627 110327663
Selective mutism 20.84 10.34 8 255001 89 110334201
Suspected suicide attempt 20.76 10.34 12 254997 352 110333938
Urinary hesitation 20.76 10.34 38 254971 4620 110329670
Squamous cell carcinoma of skin 20.53 10.34 7 255002 17196 110317094
Ear pain 20.53 10.34 59 254950 53167 110281123
Suicide threat 20.53 10.34 8 255001 93 110334197
Morbid thoughts 20.52 10.34 17 254992 902 110333388
Hyperammonaemia 20.48 10.34 74 254935 13658 110320632
Pain threshold decreased 20.46 10.34 6 255003 26 110334264
Obsessive-compulsive disorder 20.45 10.34 49 254960 7192 110327098
Thoracic outlet syndrome 20.45 10.34 9 255000 145 110334145
Renal ischaemia 20.43 10.34 26 254983 2297 110331993
Foetal exposure during pregnancy 20.36 10.34 50 254959 7455 110326835
Negativism 20.36 10.34 17 254992 912 110333378
Poor venous access 20.35 10.34 16 254993 24506 110309784
Spasmodic dysphonia 20.32 10.34 14 254995 561 110333729
Suspected counterfeit product 20.30 10.34 16 254993 790 110333500
Vertigo 20.30 10.34 297 254712 86573 110247717
Formication 20.20 10.34 42 254967 5606 110328684
Base excess 20.16 10.34 7 255002 57 110334233
Disorganised speech 20.13 10.34 31 254978 3272 110331018
Mood altered 20.04 10.34 100 254909 21275 110313015
Urine sodium increased 20.02 10.34 10 254999 217 110334073
Hypoaesthesia oral 19.99 10.34 85 254924 16917 110317373
Inappropriate affect 19.88 10.34 22 254987 1677 110332613
Bladder cancer 19.87 10.34 11 254998 20281 110314009
Acute graft versus host disease 19.83 10.34 3 255006 12878 110321412
Respiratory symptom 19.81 10.34 5 255004 14940 110319350
Hepatic necrosis 19.77 10.34 59 254950 9863 110324427
Metastases to bone 19.74 10.34 26 254983 31346 110302944
Vitamin D abnormal 19.74 10.34 10 254999 224 110334066
Intervertebral disc disorder 19.73 10.34 41 254968 5471 110328819
High risk sexual behaviour 19.72 10.34 8 255001 104 110334186
Right ventricular hypertrophy 19.67 10.34 22 254987 1697 110332593
Haemoptysis 19.65 10.34 91 254918 71263 110263027
Injection site bruising 19.64 10.34 57 254952 51206 110283084
Appendicitis 19.59 10.34 22 254987 28442 110305848
Biliary ischaemia 19.59 10.34 8 255001 106 110334184
Pain in jaw 19.54 10.34 57 254952 51120 110283170
Myocardial depression 19.46 10.34 15 254994 717 110333573
Diverticulitis 19.44 10.34 61 254948 53461 110280829
Blood sodium decreased 19.37 10.34 153 254856 38166 110296124
Enteritis 19.32 10.34 10 254999 19146 110315144
Prescribed underdose 19.23 10.34 81 254928 65093 110269197
Prescription form tampering 19.16 10.34 13 254996 508 110333782
Cardiac hypertrophy 19.07 10.34 23 254986 1924 110332366
Executive dysfunction 19.04 10.34 12 254997 413 110333877
Facial spasm 19.04 10.34 16 254993 866 110333424
Gait deviation 18.88 10.34 8 255001 117 110334173
Myocarditis septic 18.86 10.34 6 255003 36 110334254
Blood osmolarity decreased 18.80 10.34 20 254989 1458 110332832
Distractibility 18.74 10.34 16 254993 885 110333405
Pulmonary contusion 18.73 10.34 9 255000 179 110334111
Accommodation disorder 18.72 10.34 14 254995 639 110333651
Device difficult to use 18.70 10.34 10 254999 18795 110315495
Tissue infiltration 18.65 10.34 17 254992 1026 110333264
Oral discomfort 18.64 10.34 63 254946 11248 110323042
Anxiety disorder 18.64 10.34 38 254971 5002 110329288
Breathing-related sleep disorder 18.56 10.34 10 254999 255 110334035
Chest pain 18.55 10.34 695 254314 375680 109958610
Carcinoid tumour of the stomach 18.55 10.34 9 255000 183 110334107
Alcohol intolerance 18.49 10.34 12 254997 435 110333855
Hypophosphataemia 18.43 10.34 30 254979 33152 110301138
Impulse-control disorder 18.42 10.34 24 254985 2170 110332120
Crystalluria 18.42 10.34 19 254990 1336 110332954
Cyclothymic disorder 18.42 10.34 10 254999 259 110334031
Pneumonia bacterial 18.40 10.34 20 254989 26241 110308049
Illness anxiety disorder 18.39 10.34 10 254999 260 110334030
Haematuria 18.34 10.34 114 254895 82891 110251399
Rash erythematous 18.29 10.34 112 254897 81720 110252570
Bradycardia foetal 18.23 10.34 8 255001 128 110334162
Decreased interest 18.15 10.34 37 254972 4871 110329419
Illogical thinking 18.15 10.34 7 255002 79 110334211
Metastases to lymph nodes 18.14 10.34 6 255003 15026 110319264
Oxygen saturation abnormal 18.09 10.34 40 254969 5571 110328719
Ejaculation delayed 18.08 10.34 9 255000 194 110334096
Enterochromaffin cell hyperplasia 17.99 10.34 7 255002 81 110334209
Insomnia 17.98 10.34 1010 253999 359580 109974710
Myasthenia gravis 17.90 10.34 14 254995 21497 110312793
Skin fissures 17.84 10.34 18 254991 24440 110309850
Dissociative disorder 17.84 10.34 18 254991 1233 110333057
Change in seizure presentation 17.74 10.34 15 254994 819 110333471
Refraction disorder 17.69 10.34 7 255002 85 110334205
Infective pulmonary exacerbation of cystic fibrosis 17.64 10.34 6 255003 14765 110319525
Blood osmolarity increased 17.63 10.34 15 254994 826 110333464
Tachypnoea 17.61 10.34 153 254856 39242 110295048
Cerebrovascular accident 17.54 10.34 303 254706 180981 110153309
Performance fear 17.54 10.34 4 255005 4 110334286
Posturing 17.46 10.34 17 254992 1115 110333175
Immunosuppressant drug level increased 17.44 10.34 3 255006 11721 110322569
Cushingoid 17.42 10.34 3 255006 11709 110322581
Urine osmolarity increased 17.40 10.34 10 254999 290 110334000
Negative symptoms in schizophrenia 17.39 10.34 9 255000 211 110334079
Faecal disimpaction 17.37 10.34 5 255004 20 110334270
Injection site rash 17.36 10.34 17 254992 23402 110310888
Electrocardiogram repolarisation abnormality 17.26 10.34 24 254985 2311 110331979
Blood bicarbonate decreased 17.21 10.34 40 254969 5757 110328533
Hepatomegaly 17.21 10.34 96 254913 21318 110312972
Parosmia 17.16 10.34 68 254941 13112 110321178
Analgesic drug level above therapeutic 17.07 10.34 12 254997 497 110333793
Benzodiazepine drug level abnormal 17.07 10.34 4 255005 5 110334285
Osmolar gap abnormal 17.05 10.34 7 255002 94 110334196
Oesophageal carcinoma 17.03 10.34 3 255006 11521 110322769
Brain death 17.00 10.34 43 254966 6530 110327760
Starvation 16.99 10.34 16 254993 1007 110333283
Learning disorder 16.98 10.34 14 254995 738 110333552
Full blood count decreased 16.93 10.34 30 254979 32069 110302221
Cholinergic syndrome 16.90 10.34 18 254991 1314 110332976
Myofascial pain syndrome 16.89 10.34 25 254984 2548 110331742
Cytomegalovirus viraemia 16.86 10.34 10 254999 17754 110316536
Quadriparesis 16.83 10.34 35 254974 4672 110329618
Renal function test abnormal 16.71 10.34 52 254957 8894 110325396
Psychiatric symptom 16.70 10.34 53 254956 9160 110325130
Libido decreased 16.59 10.34 40 254969 5895 110328395
Dysgeusia 16.59 10.34 94 254915 69891 110264399
Cardiac death 16.55 10.34 20 254989 1676 110332614
Aplastic anaemia 16.50 10.34 19 254990 24289 110310001
Sensory loss 16.46 10.34 95 254914 21362 110312928
Cholestasis 16.45 10.34 224 254785 64294 110269996
Akinesia 16.45 10.34 30 254979 3637 110330653
Drug dose titration not performed 16.44 10.34 16 254993 1049 110333241
Oral pain 16.35 10.34 39 254970 37405 110296885
Crime 16.29 10.34 6 255003 59 110334231
Anticonvulsant drug level increased 16.28 10.34 26 254983 2832 110331458
Hyporesponsive to stimuli 16.26 10.34 26 254983 2834 110331456
Sexually inappropriate behaviour 16.22 10.34 13 254996 658 110333632
Skin haemorrhage 16.22 10.34 20 254989 24807 110309483
Libido disorder 16.19 10.34 10 254999 332 110333958
Pancreatic carcinoma 16.17 10.34 7 255002 14865 110319425
Postural reflex impairment 16.15 10.34 5 255004 27 110334263
Throat irritation 16.15 10.34 66 254943 53486 110280804
Normal newborn 16.11 10.34 16 254993 21880 110312410
Skin reaction 16.08 10.34 15 254994 21129 110313161
Genital erosion 16.05 10.34 14 254995 797 110333493
Frontotemporal dementia 16.02 10.34 13 254996 670 110333620
Ankylosing spondylitis 15.97 10.34 8 255001 15604 110318686
Screaming 15.97 10.34 35 254974 4846 110329444
Pneumonia fungal 15.96 10.34 7 255002 14747 110319543
Basilar migraine 15.94 10.34 6 255003 63 110334227
Cardiomyopathy 15.94 10.34 132 254877 33393 110300897
Central pain syndrome 15.92 10.34 14 254995 806 110333484
Porphyria acute 15.91 10.34 12 254997 18768 110315522
Sneezing 15.89 10.34 31 254978 31953 110302337
Dehydration 15.88 10.34 507 254502 279004 110055286
Gun shot wound 15.86 10.34 16 254993 1096 110333194
Chronic fatigue syndrome 15.86 10.34 18 254991 1411 110332879
Phonophobia 15.85 10.34 13 254996 680 110333610
Depressive symptom 15.80 10.34 49 254960 8365 110325925
Hyperglycaemia 15.78 10.34 123 254886 84967 110249323
Sudden cardiac death 15.76 10.34 38 254971 5599 110328691
Macular degeneration 15.73 10.34 16 254993 21643 110312647
Hypernatraemia 15.72 10.34 82 254927 17751 110316539
Brief psychotic disorder with marked stressors 15.72 10.34 10 254999 350 110333940
Tenosynovitis 15.69 10.34 9 255000 16274 110318016
Oropharyngeal oedema 15.68 10.34 11 254998 454 110333836
Feeling abnormal 15.67 10.34 536 254473 180175 110154115
Hepatitis C 15.67 10.34 64 254945 12509 110321781
Tachyphrenia 15.62 10.34 23 254986 2333 110331957
Dysphemia 15.60 10.34 31 254978 4006 110330284
Circulating anticoagulant positive 15.57 10.34 5 255004 31 110334259
Bruxism 15.42 10.34 35 254974 4959 110329331
Self-destructive behaviour 15.42 10.34 14 254995 841 110333449
Hallucination, olfactory 15.41 10.34 12 254997 582 110333708
Inappropriate antidiuretic hormone secretion 15.41 10.34 132 254877 33719 110300571
Drug-device interaction 15.41 10.34 7 255002 122 110334168
Respiratory alkalosis 15.40 10.34 38 254971 5683 110328607
Anticonvulsant drug level below therapeutic 15.27 10.34 16 254993 1146 110333144
Lung opacity 15.25 10.34 4 255005 11648 110322642
Lactate pyruvate ratio increased 15.22 10.34 6 255003 72 110334218
Protrusion tongue 15.20 10.34 11 254998 477 110333813
Skin exfoliation 15.20 10.34 129 254880 87522 110246768
Neoplasm malignant 15.20 10.34 40 254969 37103 110297187
Hyperinsulinaemia 15.15 10.34 9 255000 278 110334012
Angina pectoris 15.13 10.34 83 254926 62212 110272078
Hypertensive heart disease 15.08 10.34 33 254976 4563 110329727
Creatinine renal clearance decreased 15.08 10.34 94 254915 21721 110312569
Tendonitis 15.04 10.34 23 254986 26060 110308230
Mental status changes 15.03 10.34 253 254756 75869 110258421
Panic reaction 15.02 10.34 36 254973 5286 110329004
Antipsychotic drug level above therapeutic 15.01 10.34 23 254986 2417 110331873
Ischaemic stroke 15.00 10.34 47 254962 41216 110293074
Reaction to excipient 14.97 10.34 21 254988 2038 110332252
Aspartate aminotransferase increased 14.94 10.34 269 254740 159667 110174623
Ulcer haemorrhage 14.94 10.34 18 254991 22553 110311737
Suspected suicide 14.89 10.34 72 254937 15127 110319163
Tonic convulsion 14.88 10.34 26 254983 3048 110331242
Sinus rhythm 14.86 10.34 15 254994 1028 110333262
Product administration error 14.83 10.34 141 254868 37076 110297214
Foaming at mouth 14.82 10.34 22 254987 2248 110332042
Traumatic coma 14.79 10.34 6 255003 78 110334212
Allodynia 14.78 10.34 21 254988 2062 110332228
Upper-airway cough syndrome 14.74 10.34 74 254935 15783 110318507
Monoplegia 14.71 10.34 34 254975 4875 110329415
Personal relationship issue 14.71 10.34 8 255001 208 110334082
Blood pressure diastolic increased 14.71 10.34 13 254996 18794 110315496
Penile haemorrhage 14.70 10.34 14 254995 894 110333396
Blood calcium increased 14.68 10.34 12 254997 18028 110316262
Apraxia 14.68 10.34 28 254981 3512 110330778
Ventricular compliance decreased 14.59 10.34 5 255004 39 110334251
Substance-induced psychotic disorder 14.57 10.34 36 254973 5388 110328902
Subileus 14.50 10.34 40 254969 6397 110327893
Antasthmatic drug level 14.48 10.34 5 255004 40 110334250
Electrocardiogram T wave amplitude increased 14.46 10.34 6 255003 83 110334207
Retrograde amnesia 14.41 10.34 13 254996 774 110333516
Blood calcium decreased 14.39 10.34 136 254873 35709 110298581
Anticonvulsant drug level decreased 14.38 10.34 21 254988 2115 110332175
Needle issue 14.36 10.34 12 254997 17828 110316462
Tonic clonic movements 14.33 10.34 25 254984 2927 110331363
Gastrooesophageal reflux disease 14.30 10.34 311 254698 179665 110154625
Cerebrospinal fluid leakage 14.29 10.34 21 254988 2127 110332163
Multiple injuries 14.27 10.34 28 254981 3586 110330704
Femoral nerve palsy 14.27 10.34 6 255003 86 110334204
Periorbital swelling 14.22 10.34 36 254973 5469 110328821
Pneumoconiosis 14.20 10.34 9 255000 313 110333977
Tongue discolouration 14.19 10.34 30 254979 4051 110330239
Lower gastrointestinal haemorrhage 14.19 10.34 13 254996 18473 110315817
Forearm fracture 14.16 10.34 12 254997 657 110333633
Dizziness 14.14 10.34 1402 253607 696791 109637499
Laboratory test abnormal 14.14 10.34 53 254956 44026 110290264
Communication disorder 14.13 10.34 34 254975 5005 110329285
Violence-related symptom 14.05 10.34 14 254995 945 110333345
Slow response to stimuli 14.05 10.34 20 254989 1968 110332322
Phyllodes tumour 14.02 10.34 6 255003 90 110334200
Right ventricular dilatation 13.99 10.34 22 254987 2365 110331925
Analgesic drug level 13.96 10.34 5 255004 45 110334245
Cerebral haemorrhage 13.96 10.34 90 254919 64878 110269412
Moaning 13.94 10.34 17 254992 1438 110332852
Systemic candida 13.89 10.34 3 255006 9971 110324319
Macroglossia 13.89 10.34 17 254992 1444 110332846
Porphyria 13.80 10.34 8 255001 236 110334054
Impaired driving ability 13.77 10.34 39 254970 6331 110327959
Enterococcal infection 13.74 10.34 16 254993 20350 110313940
Uterine enlargement 13.73 10.34 14 254995 971 110333319
Escherichia infection 13.73 10.34 21 254988 23795 110310495
Lid lag 13.73 10.34 7 255002 159 110334131
Metastases to lung 13.62 10.34 20 254989 23043 110311247
Systemic infection 13.58 10.34 3 255006 9816 110324474
Movement disorder 13.57 10.34 136 254873 36268 110298022
Postprandial hypoglycaemia 13.57 10.34 7 255002 163 110334127
Second primary malignancy 13.52 10.34 13 254996 18055 110316235
Encephalomalacia 13.51 10.34 17 254992 1485 110332805
Herpes simplex 13.45 10.34 10 254999 15754 110318536
Multiple lentigines syndrome 13.44 10.34 8 255001 248 110334042
Gait disturbance 13.43 10.34 777 254232 277431 110056859
Prostatic specific antigen increased 13.43 10.34 6 255003 12505 110321785
Cerebrovascular stenosis 13.42 10.34 7 255002 167 110334123
Physical abuse 13.41 10.34 5 255004 51 110334239
Blood uric acid increased 13.39 10.34 18 254991 21511 110312779
Pupillary reflex impaired 13.37 10.34 29 254980 3986 110330304
Enthesopathy 13.37 10.34 6 255003 12472 110321818
Attention deficit hyperactivity disorder 13.35 10.34 31 254978 4460 110329830
Acute myocardial infarction 13.35 10.34 126 254883 83651 110250639
Distal intestinal obstruction syndrome 13.27 10.34 14 254995 1011 110333279
Blood citric acid increased 13.24 10.34 5 255004 53 110334237
Hemiplegia 13.22 10.34 20 254989 22762 110311528
Diabetic ketoacidosis 13.21 10.34 51 254958 42007 110292283
Hypotensive crisis 13.19 10.34 7 255002 173 110334117
Oral herpes 13.19 10.34 41 254968 36039 110298251
Diabetes mellitus 13.18 10.34 156 254853 99225 110235065
Eczema 13.17 10.34 105 254904 72188 110262102
Tonic posturing 13.15 10.34 3 255006 3 110334287
Congenital hypothyroidism 13.15 10.34 3 255006 3 110334287
Anaesthesia 13.13 10.34 11 254998 593 110333697
Chemical poisoning 13.12 10.34 7 255002 175 110334115
Foetal anticonvulsant syndrome 13.10 10.34 8 255001 260 110334030
Pupil fixed 13.10 10.34 28 254981 3810 110330480
Nervous system disorder 13.05 10.34 121 254888 31600 110302690
Lack of spontaneous speech 13.02 10.34 8 255001 263 110334027
Post-traumatic stress disorder 12.93 10.34 39 254970 6557 110327733
Proteinuria 12.91 10.34 48 254961 39970 110294320
Eosinophil count increased 12.88 10.34 88 254921 20970 110313320
Mitral valve disease 12.88 10.34 26 254983 3399 110330891
Renal failure 12.86 10.34 411 254598 226163 110108127
Emotional disorder of childhood 12.86 10.34 4 255005 22 110334268
Claustrophobia 12.84 10.34 17 254992 1562 110332728
Confusional arousal 12.84 10.34 7 255002 183 110334107
Exposure during pregnancy 12.82 10.34 291 254718 167133 110167157
Impaired self-care 12.82 10.34 22 254987 2542 110331748
Pleuritic pain 12.81 10.34 11 254998 16129 110318161
Amnesia 12.78 10.34 326 254683 105082 110229208
Binge drinking 12.71 10.34 4 255005 23 110334267
Enterocolitis 12.66 10.34 15 254994 18934 110315356
Metabolic syndrome 12.63 10.34 25 254984 3222 110331068
Skull fractured base 12.59 10.34 9 255000 383 110333907
Osteonecrosis 12.58 10.34 38 254971 33703 110300587
Benzodiazepine drug level therapeutic 12.57 10.34 4 255005 24 110334266
Intestinal infarction 12.57 10.34 16 254993 1414 110332876
Blood ethanol increased 12.56 10.34 11 254998 630 110333660
Facial nerve disorder 12.55 10.34 12 254997 770 110333520
Fall 12.54 10.34 1582 253427 601900 109732390
Gastric lavage 12.54 10.34 5 255004 62 110334228
Gastrointestinal toxicity 12.52 10.34 5 255004 11143 110323147
Posture abnormal 12.50 10.34 30 254979 4408 110329882
Kidney transplant rejection 12.48 10.34 6 255003 11981 110322309
Haemorrhage 12.47 10.34 172 254837 106520 110227770
Oral candidiasis 12.37 10.34 57 254952 44703 110289587
Pulmonary alveolar haemorrhage 12.37 10.34 17 254992 20133 110314157
Gout 12.37 10.34 43 254966 36523 110297767
Encephalitis autoimmune 12.35 10.34 26 254983 3502 110330788
Thyroid adenoma 12.34 10.34 7 255002 198 110334092
Weight fluctuation 12.32 10.34 20 254989 22125 110312165
Eye haematoma 12.28 10.34 8 255001 292 110333998
Hyponatraemic coma 12.26 10.34 5 255004 66 110334224
Eye irritation 12.24 10.34 38 254971 33414 110300876
Electrocardiogram PR prolongation 12.23 10.34 18 254991 1825 110332465
Abdominal tenderness 12.19 10.34 59 254950 12398 110321892
Sciatic nerve neuropathy 12.19 10.34 10 254999 523 110333767
Lacrimation increased 12.16 10.34 34 254975 30916 110303374
Colon cancer 12.11 10.34 12 254997 16431 110317859
Sinus disorder 12.10 10.34 37 254972 32691 110301599
Cerebral ataxia 12.05 10.34 4 255005 28 110334262
Arteriosclerosis 12.03 10.34 98 254911 24669 110309621
Megacolon 12.02 10.34 29 254980 4276 110330014
Intraocular pressure increased 12.02 10.34 5 255004 10871 110323419
Therapeutic response shortened 12.00 10.34 32 254977 29551 110304739
Wrong patient 11.97 10.34 16 254993 1483 110332807
Polyneuropathy 11.97 10.34 36 254973 31976 110302314
Educational problem 11.95 10.34 10 254999 538 110333752
Alcohol test positive 11.94 10.34 3 255006 6 110334284
Tarsal tunnel syndrome 11.93 10.34 10 254999 539 110333751
Lung neoplasm malignant 11.93 10.34 125 254884 33717 110300573
Administration related reaction 11.92 10.34 8 255001 307 110333983
Intestinal dilatation 11.89 10.34 26 254983 3594 110330696
Product communication issue 11.88 10.34 21 254988 2485 110331805
Coma scale 11.87 10.34 5 255004 72 110334218
Cardiotoxicity 11.83 10.34 73 254936 16808 110317482
Arthritis enteropathic 11.83 10.34 9 255000 422 110333868
Guillain-Barre syndrome 11.77 10.34 5 255004 10739 110323551
Neuroprosthesis implantation 11.69 10.34 4 255005 31 110334259
Oral mucosal eruption 11.68 10.34 14 254995 1163 110333127
Dysphoria 11.67 10.34 37 254972 6391 110327899
Stereotypy 11.61 10.34 13 254996 1004 110333286
White blood cell count increased 11.60 10.34 299 254710 96543 110237747
Diabetic retinal oedema 11.59 10.34 9 255000 435 110333855
Dermatitis bullous 11.58 10.34 14 254995 17515 110316775
Intestinal perforation 11.57 10.34 19 254990 20925 110313365
Terminal insomnia 11.55 10.34 18 254991 1920 110332370
Cerebral congestion 11.54 10.34 7 255002 225 110334065
Hypersexuality 11.53 10.34 18 254991 1922 110332368
Aortic stenosis 11.51 10.34 8 255001 13051 110321239
Piloerection 11.48 10.34 12 254997 857 110333433
Respiratory dyskinesia 11.45 10.34 5 255004 79 110334211
Left ventricular dysfunction 11.44 10.34 93 254916 23400 110310890
Skin abrasion 11.42 10.34 70 254939 16081 110318209
Extremity contracture 11.40 10.34 17 254992 1744 110332546
Mesenteric vascular occlusion 11.39 10.34 5 255004 80 110334210
Basophil count decreased 11.38 10.34 9 255000 447 110333843
Thymus disorder 11.37 10.34 10 254999 576 110333714
Electrocardiogram abnormal 11.34 10.34 78 254931 18631 110315659
Ventricular dyskinesia 11.32 10.34 9 255000 450 110333840
Blood loss anaemia 11.28 10.34 15 254994 18010 110316280
Aplasia pure red cell 11.25 10.34 4 255005 9574 110324716
Portal hypertension 11.24 10.34 3 255006 8634 110325656
Electrocardiogram ST segment abnormal 11.23 10.34 17 254992 1768 110332522
Pain of skin 11.23 10.34 18 254991 20011 110314279
Psychiatric decompensation 11.22 10.34 34 254975 5731 110328559
Abdominal pain lower 11.21 10.34 46 254963 37237 110297053
Diastolic hypotension 11.20 10.34 8 255001 340 110333950
Hyperphagia 11.19 10.34 25 254984 3506 110330784
Consciousness fluctuating 11.19 10.34 19 254990 2177 110332113
Polyglandular disorder 11.16 10.34 7 255002 239 110334051
Temperature regulation disorder 11.12 10.34 8 255001 12818 110321472
Gamma-glutamyltransferase increased 11.11 10.34 201 254808 61108 110273182
Vaginal discharge 11.11 10.34 15 254994 17893 110316397
Vascular device infection 11.11 10.34 13 254996 16499 110317791
Tenderness 11.08 10.34 33 254976 29404 110304886
Detoxification 11.06 10.34 5 255004 86 110334204
Unmasking of previously unidentified disease 11.06 10.34 22 254987 2846 110331444
Neurological decompensation 11.05 10.34 38 254971 6845 110327445
Hypergastrinaemia 11.04 10.34 8 255001 348 110333942
Pneumatosis intestinalis 11.03 10.34 3 255006 8526 110325764
Tooth hypoplasia 11.02 10.34 8 255001 349 110333941
Accident at work 11.01 10.34 14 254995 1236 110333054
Cor pulmonale acute 10.96 10.34 11 254998 749 110333541
Acne 10.95 10.34 40 254969 33480 110300810
Subdural haematoma 10.94 10.34 45 254964 36409 110297881
Heart rate decreased 10.94 10.34 130 254879 82626 110251664
Electrocardiogram ST segment elevation 10.93 10.34 46 254963 9114 110325176
Aphthous ulcer 10.93 10.34 20 254989 21116 110313174
Skin cancer 10.92 10.34 15 254994 17769 110316521
Affect lability 10.88 10.34 77 254932 18560 110315730
Radial nerve palsy 10.87 10.34 9 255000 477 110333813
Cholangitis 10.84 10.34 13 254996 16322 110317968
Herbal interaction 10.80 10.34 10 254999 616 110333674
Xanthelasma 10.80 10.34 6 255003 163 110334127
Brain hypoxia 10.73 10.34 14 254995 1268 110333022
Hyperventilation 10.73 10.34 45 254964 8902 110325388
Neurological examination normal 10.71 10.34 4 255005 41 110334249
Weight 10.71 10.34 4 255005 41 110334249
Performance enhancing product use 10.66 10.34 6 255003 167 110334123
Increased appetite 10.64 10.34 65 254944 14912 110319378
Thrombocytosis 10.61 10.34 50 254959 10394 110323896
Azotaemia 10.57 10.34 5 255004 10080 110324210
Aura 10.56 10.34 13 254996 1111 110333179
Areflexia 10.54 10.34 37 254972 6732 110327558
Hyporeflexia 10.53 10.34 27 254982 4133 110330157
Pancreatitis 10.50 10.34 152 254857 93381 110240909
Graft versus host disease in skin 10.49 10.34 3 255006 8251 110326039
Sensitivity to weather change 10.47 10.34 5 255004 10023 110324267
Choreoathetosis 10.44 10.34 16 254993 1682 110332608
CSF lymphocyte count increased 10.42 10.34 3 255006 12 110334278
Stoma site ischaemia 10.42 10.34 3 255006 12 110334278
Peritoneal perforation 10.41 10.34 6 255003 175 110334115
Injection site haemorrhage 10.40 10.34 40 254969 32988 110301302
Hypomagnesaemia 10.40 10.34 89 254920 60281 110274009
Counterfeit product administered 10.40 10.34 7 255002 270 110334020
Joint dislocation 10.39 10.34 42 254967 34148 110300142
Atopic keratoconjunctivitis 10.38 10.34 4 255005 45 110334245
Therapy partial responder 10.36 10.34 47 254962 37014 110297276
Presyncope 10.36 10.34 68 254941 48819 110285471
Fistula 10.34 10.34 12 254997 15287 110319003

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N05BA01 NERVOUS SYSTEM
PSYCHOLEPTICS
ANXIOLYTICS
Benzodiazepine derivatives
FDA CS M0002356 Benzodiazepines
MeSH PA D000759 Adjuvants, Anesthesia
MeSH PA D000777 Anesthetics
MeSH PA D000927 Anticonvulsants
MeSH PA D000932 Antiemetics
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D005765 Gastrointestinal Agents
MeSH PA D006993 Hypnotics and Sedatives
MeSH PA D009125 Muscle Relaxants, Central
MeSH PA D009465 Neuromuscular Agents
MeSH PA D011619 Psychotropic Drugs
MeSH PA D014151 Anti-Anxiety Agents
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018682 GABA Agents
MeSH PA D018686 Anesthetics, Intravenous
MeSH PA D018757 GABA Modulators
FDA EPC N0000175694 Benzodiazepine
CHEBI has role CHEBI:35469 antidepressant
CHEBI has role CHEBI:35474 anxiolytic drug
CHEBI has role CHEBI:35476 antipsychotic agent
CHEBI has role CHEBI:35480 analgesic
CHEBI has role CHEBI:35623 anticonvulsant
CHEBI has role CHEBI:35703 xenobiotic
CHEBI has role CHEBI:35717 sedative
CHEBI has role CHEBI:73336 vulnerary
CHEBI has role CHEBI:78298 environmental contaminant

Related Drugs by ATC class:

N05BA Benzodiazepine derivatives 23 drugs
adinazolamalprazolambentazepambromazepamcamazepamchlordiazepoxideclobazamclorazepateclotiazepamcloxazolamethyl loflazepateetizolam show all 23 →

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Alcohol withdrawal delirium indication 8635005
Anxiety indication 48694002
Sedation indication 72641008
Tetanus indication 76902006 DOID:11338
Epilepsy indication 84757009 DOID:1826
Alcohol withdrawal syndrome indication 191480000
Spasticity indication 221360009
Status epilepticus indication 230456007 DOID:1824
Induce Anterograde Amnesia indication
Preoperative Anxiety indication
Panic disorder off-label use 371631005 DOID:594
Cocaine-Associated Acute Ischemic Heart Disease off-label use
Disorder of lung contraindication 19829001 DOID:850
Alcohol intoxication contraindication 25702006
Depressive disorder contraindication 35489007
Acute nephropathy contraindication 58574008
Hepatic failure contraindication 59927004
Substance abuse contraindication 66214007
Sleep apnea contraindication 73430006 DOID:0050847
Decreased respiratory function contraindication 80954004
Open-angle glaucoma contraindication 84494001 DOID:1067
Myasthenia gravis contraindication 91637004 DOID:437
Hypoalbuminemia contraindication 119247004
Disease of liver contraindication 235856003 DOID:409
Pregnancy, function contraindication 289908002
Severe chronic obstructive pulmonary disease contraindication 313299006
Angle-closure glaucoma contraindication 392291006 DOID:13550
Breastfeeding (mother) contraindication 413712001




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.06 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
10MG/SPRAY VALTOCO NEURELIS INC N211635 Jan. 10, 2020 RX SPRAY NASAL 12337061 June 13, 2032 NASAL ADMINISTRATION OF DIAZEPAM FOR THE ACUTE TREATMENT OF INTERMITTENT, STEREOTYPIC EPISODES OF FREQUENT SEIZURE ACTIVITY THAT ARE DISTINCT FROM A PATIENTS USUAL SEIZURE PATTERN IN PATIENTS WITH EPILEPSY 2 YEARS OF AGE AND OLDER
5MG/SPRAY VALTOCO NEURELIS INC N211635 Jan. 10, 2020 RX SPRAY NASAL 12337061 June 13, 2032 NASAL ADMINISTRATION OF DIAZEPAM FOR THE ACUTE TREATMENT OF INTERMITTENT, STEREOTYPIC EPISODES OF FREQUENT SEIZURE ACTIVITY THAT ARE DISTINCT FROM A PATIENTS USUAL SEIZURE PATTERN IN PATIENTS WITH EPILEPSY 2 YEARS OF AGE AND OLDER
7.5MG/SPRAY VALTOCO NEURELIS INC N211635 Jan. 10, 2020 RX SPRAY NASAL 12337061 June 13, 2032 NASAL ADMINISTRATION OF DIAZEPAM FOR THE ACUTE TREATMENT OF INTERMITTENT, STEREOTYPIC EPISODES OF FREQUENT SEIZURE ACTIVITY THAT ARE DISTINCT FROM A PATIENTS USUAL SEIZURE PATTERN IN PATIENTS WITH EPILEPSY 2 YEARS OF AGE AND OLDER
10MG/SPRAY VALTOCO NEURELIS INC N211635 Jan. 10, 2020 RX SPRAY NASAL 12324852 Oct. 16, 2032 NASAL ADMINISTRATION OF DIAZEPAM FOR THE ACUTE TREATMENT OF INTERMITTENT, STEREOTYPIC EPISODES OF FREQUENT SEIZURE ACTIVITY THAT ARE DISTINCT FROM A PATIENTS USUAL SEIZURE PATTERN IN PATIENTS WITH EPILEPSY 2 YEARS OF AGE AND OLDER
5MG/SPRAY VALTOCO NEURELIS INC N211635 Jan. 10, 2020 RX SPRAY NASAL 12324852 Oct. 16, 2032 NASAL ADMINISTRATION OF DIAZEPAM FOR THE ACUTE TREATMENT OF INTERMITTENT, STEREOTYPIC EPISODES OF FREQUENT SEIZURE ACTIVITY THAT ARE DISTINCT FROM A PATIENTS USUAL SEIZURE PATTERN IN PATIENTS WITH EPILEPSY 2 YEARS OF AGE AND OLDER
7.5MG/SPRAY VALTOCO NEURELIS INC N211635 Jan. 10, 2020 RX SPRAY NASAL 12324852 Oct. 16, 2032 NASAL ADMINISTRATION OF DIAZEPAM FOR THE ACUTE TREATMENT OF INTERMITTENT, STEREOTYPIC EPISODES OF FREQUENT SEIZURE ACTIVITY THAT ARE DISTINCT FROM A PATIENTS USUAL SEIZURE PATTERN IN PATIENTS WITH EPILEPSY 2 YEARS OF AGE AND OLDER
10MG/SPRAY VALTOCO NEURELIS INC N211635 Jan. 10, 2020 RX SPRAY NASAL 12599611 June 10, 2042 NASAL ADMINISTRATION OF DIAZEPAM FOR THE ACUTE TREATMENT OF INTERMITTENT, STEREOTYPIC EPISODES OF FREQUENT SEIZURE ACTIVITY THAT ARE DISTINCT FROM A PATIENTS USUAL SEIZURE PATTERN IN PATIENTS WITH EPILEPSY 2 YEARS TO 5 YEARS OF AGE
5MG/SPRAY VALTOCO NEURELIS INC N211635 Jan. 10, 2020 RX SPRAY NASAL 12599611 June 10, 2042 NASAL ADMINISTRATION OF DIAZEPAM FOR THE ACUTE TREATMENT OF INTERMITTENT, STEREOTYPIC EPISODES OF FREQUENT SEIZURE ACTIVITY THAT ARE DISTINCT FROM A PATIENTS USUAL SEIZURE PATTERN IN PATIENTS WITH EPILEPSY 2 YEARS TO 5 YEARS OF AGE
7.5MG/SPRAY VALTOCO NEURELIS INC N211635 Jan. 10, 2020 RX SPRAY NASAL 12599611 June 10, 2042 NASAL ADMINISTRATION OF DIAZEPAM FOR THE ACUTE TREATMENT OF INTERMITTENT, STEREOTYPIC EPISODES OF FREQUENT SEIZURE ACTIVITY THAT ARE DISTINCT FROM A PATIENTS USUAL SEIZURE PATTERN IN PATIENTS WITH EPILEPSY 2 YEARS TO 5 YEARS OF AGE

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
10MG/SPRAY VALTOCO NEURELIS INC N211635 Jan. 10, 2020 RX SPRAY NASAL Jan. 10, 2027 INDICATED FOR THE ACUTE TX OF INTERMITTENT, STEREOTYPIC EPISODES OF FREQUENT SEIZURE ACTIVITY (I.E. SEIZURE CLUSTERS, ACUTE REPETITIVE SEIZURES) THAT ARE DISTINCT FROM A PATIENT’S USUAL SEIZURE PATTERN IN PATIENTS WITH EPILEPSY 6 YEARS OF AGE AND OLDER
5MG/SPRAY VALTOCO NEURELIS INC N211635 Jan. 10, 2020 RX SPRAY NASAL Jan. 10, 2027 INDICATED FOR THE ACUTE TX OF INTERMITTENT, STEREOTYPIC EPISODES OF FREQUENT SEIZURE ACTIVITY (I.E. SEIZURE CLUSTERS, ACUTE REPETITIVE SEIZURES) THAT ARE DISTINCT FROM A PATIENT’S USUAL SEIZURE PATTERN IN PATIENTS WITH EPILEPSY 6 YEARS OF AGE AND OLDER
7.5MG/SPRAY VALTOCO NEURELIS INC N211635 Jan. 10, 2020 RX SPRAY NASAL Jan. 10, 2027 INDICATED FOR THE ACUTE TX OF INTERMITTENT, STEREOTYPIC EPISODES OF FREQUENT SEIZURE ACTIVITY (I.E. SEIZURE CLUSTERS, ACUTE REPETITIVE SEIZURES) THAT ARE DISTINCT FROM A PATIENT’S USUAL SEIZURE PATTERN IN PATIENTS WITH EPILEPSY 6 YEARS OF AGE AND OLDER
10MG/SPRAY VALTOCO NEURELIS INC N211635 Jan. 10, 2020 RX SPRAY NASAL April 15, 2028 NEW PATIENT POPULATION
5MG/SPRAY VALTOCO NEURELIS INC N211635 Jan. 10, 2020 RX SPRAY NASAL April 15, 2028 NEW PATIENT POPULATION
7.5MG/SPRAY VALTOCO NEURELIS INC N211635 Jan. 10, 2020 RX SPRAY NASAL April 15, 2028 NEW PATIENT POPULATION

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
GABA A receptor alpha-5/beta-2/gamma-3 Ion channel POSITIVE ALLOSTERIC MODULATOR Ki 7.20 WOMBAT-PK CHEMBL
GABA-A receptor alpha-1/beta-2/gamma-2 Ion channel POSITIVE ALLOSTERIC MODULATOR EC50 7.14 WOMBAT-PK CHEMBL
GABA-A receptor alpha-2/beta-3/gamma-2 Ion channel POSITIVE ALLOSTERIC MODULATOR Ki 7.70 WOMBAT-PK CHEMBL
GABA-A receptor alpha-3/beta-3/gamma-2 Ion channel POSITIVE ALLOSTERIC MODULATOR Ki 7.65 WOMBAT-PK CHEMBL
GABA-A receptor alpha-5/beta-3/gamma-2 Ion channel POSITIVE ALLOSTERIC MODULATOR Ki 7.96 WOMBAT-PK CHEMBL
GABA-A receptor alpha-1/beta-2/gamma-3 Ion channel POSITIVE ALLOSTERIC MODULATOR Ki 6.71 WOMBAT-PK CHEMBL
GABA-A receptor alpha-1/beta-3/gamma-2 Ion channel POSITIVE ALLOSTERIC MODULATOR Ki 7.85 WOMBAT-PK CHEMBL
GABA A receptor alpha-3/beta-2/gamma-2 Ion channel POSITIVE ALLOSTERIC MODULATOR Ki 7.94 WOMBAT-PK CHEMBL
GABA A receptor alpha-3/beta-2/gamma-3 Ion channel POSITIVE ALLOSTERIC MODULATOR Ki 6.67 WOMBAT-PK CHEMBL
GABA A receptor alpha-5/beta-3/gamma-3 Ion channel POSITIVE ALLOSTERIC MODULATOR Ki 7.20 WOMBAT-PK CHEMBL
GABA A receptor alpha-5/beta-2/gamma-2 Ion channel POSITIVE ALLOSTERIC MODULATOR Ki 8.00 WOMBAT-PK CHEMBL
Gamma-aminobutyric acid receptor subunit alpha-5 Ion channel Kd 7.64 CHEMBL
Cytochrome P450 3A4 Enzyme Ki 4.42 WOMBAT-PK
Alpha-1A adrenergic receptor GPCR ALLOSTERIC MODULATOR Ki 4.10 IUPHAR
Adenosine receptor A3 GPCR IC50 7.92 CHEMBL
Aldo-keto reductase family 1 member C1 Enzyme IC50 5.25 CHEMBL
Aldo-keto reductase family 1 member C2 Enzyme IC50 5.62 CHEMBL
Aldo-keto reductase family 1 member C3 Enzyme IC50 4.08 CHEMBL
Cholinesterase Enzyme Ki 7.37 CHEMBL
Gamma-aminobutyric acid receptor subunit alpha-1 Ion channel Ki 7.96 CHEMBL
Gamma-aminobutyric acid receptor subunit alpha-2 Ion channel Ki 7.82 CHEMBL
Gamma-aminobutyric acid receptor subunit alpha-5 Ion channel Ki 8.01 CHEMBL
GABA A receptor alpha-6/beta-2/gamma-2 Ion channel Ki 8.68 CHEMBL
GABA-A receptor; alpha-1/beta-2/gamma-2 Ion channel Ki 7.92 CHEMBL
GABA-A receptor; anion channel Ion channel Ki 4.07 CHEMBL
GABA A receptor alpha-2/beta-2/gamma-2 Ion channel Ki 7.70 CHEMBL
GABA A receptor alpha-5/beta-3/gamma-2 Ion channel Ki 7.96 CHEMBL
GABA-A receptor; anion channel Ion channel Ki 8.54 CHEMBL
GABA-A receptor; anion channel Ion channel Ki 8 CHEMBL
GABA A receptor alpha-3/beta-2/gamma-2 Ion channel Ki 7.86 CHEMBL
Fatty acid-binding protein, liver Cytosolic other Ki 6.27 CHEMBL
Acetylcholinesterase Enzyme Ki 4.89 CHEMBL
Translocator protein Membrane receptor Kd 6.67 CHEMBL
Thyrotropin-releasing hormone receptor GPCR ANTAGONIST Ki 5.15 IUPHAR

External reference:

IDSource
4017796 VUID
N0000146157 NUI
D00293 KEGG_DRUG
202472 RXNORM
4017796 VANDF
C0012010 UMLSCUI
CHEBI:49575 CHEBI
DZP PDB_CHEM_ID
CHEMBL12 ChEMBL_ID
DB00829 DRUGBANK_ID
D003975 MESH_DESCRIPTOR_UI
3016 PUBCHEM_CID
3364 IUPHAR_LIGAND_ID
1295 INN_ID
Q3JTX2Q7TU UNII
3018 MMSL
4573 MMSL
894 MMSL
d00148 MMSL
001461 NDDF
387264003 SNOMEDCT_US
48546005 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Diazepam Intensol HUMAN PRESCRIPTION DRUG LABEL 1 0054-3185 SOLUTION, CONCENTRATE 5 mg ORAL ANDA 22 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0054-3188 SOLUTION 5 mg ORAL ANDA 23 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0121-0905 SOLUTION 5 mg ORAL ANDA 24 sections
Valium HUMAN PRESCRIPTION DRUG LABEL 1 0140-0004 TABLET 2 mg ORAL NDA 28 sections
Valium HUMAN PRESCRIPTION DRUG LABEL 1 0140-0005 TABLET 5 mg ORAL NDA 28 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0172-3925 TABLET 2 mg ORAL ANDA 16 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0172-3926 TABLET 5 mg ORAL ANDA 16 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0172-3927 TABLET 10 mg ORAL ANDA 16 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0378-0271 TABLET 2 mg ORAL ANDA 28 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0378-0345 TABLET 5 mg ORAL ANDA 28 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0378-0477 TABLET 10 mg ORAL ANDA 28 sections
DIAZEPAM HUMAN PRESCRIPTION DRUG LABEL 1 0404-9762 INJECTION 5 mg INTRAMUSCULAR ANDA 14 sections
DIAZEPAM HUMAN PRESCRIPTION DRUG LABEL 1 0404-9769 INJECTION 5 mg INTRAMUSCULAR ANDA 15 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0404-9848 INJECTION, SOLUTION 5 mg INTRAVENOUS ANDA 15 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0404-9848 INJECTION, SOLUTION 5 mg INTRAVENOUS ANDA 15 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0409-1273 INJECTION, SOLUTION 5 mg INTRAMUSCULAR ANDA 20 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0409-3213 INJECTION, SOLUTION 5 mg INTRAMUSCULAR ANDA 21 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0641-6243 INJECTION 5 mg INTRAMUSCULAR ANDA 14 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0641-6244 INJECTION 5 mg INTRAMUSCULAR ANDA 15 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0641-6283 INJECTION, SOLUTION 5 mg INTRAMUSCULAR ANDA 14 sections
LIBERVANT HUMAN PRESCRIPTION DRUG LABEL 1 10094-305 FILM 5 mg BUCCAL NDA 33 sections
LIBERVANT HUMAN PRESCRIPTION DRUG LABEL 1 10094-307 FILM 7.50 mg BUCCAL NDA 33 sections
LIBERVANT HUMAN PRESCRIPTION DRUG LABEL 1 10094-310 FILM 10 mg BUCCAL NDA 33 sections
LIBERVANT HUMAN PRESCRIPTION DRUG LABEL 1 10094-312 FILM 12.50 mg BUCCAL NDA 33 sections
LIBERVANT HUMAN PRESCRIPTION DRUG LABEL 1 10094-315 FILM 15 mg BUCCAL NDA 33 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 10544-161 TABLET 10 mg ORAL ANDA 26 sections
DIAZEPAM Human Prescription Drug Label 1 11534-199 TABLET 10 mg ORAL ANDA 18 sections
DIAZEPAM Human Prescription Drug Label 1 11534-202 TABLET 2 mg ORAL ANDA 18 sections
DIAZEPAM Human Prescription Drug Label 1 11534-203 TABLET 5 mg ORAL ANDA 18 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 11704-600 INJECTION 10 mg INTRAMUSCULAR NDA 23 sections