ethyl loflazepate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
diazepam derivatives	1092	29177-84-2

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

ethyl flucozepate
CM 6912
ethyl loflazepate
meilax
victan
CM6912
CM-6912

Molecular weight: 360.77
Formula: C18H14ClFN2O3
CLOGP: 3.19
LIPINSKI: 0
HAC: 5
HDO: 1
TPSA: 67.76
ALOGS: -4.84
ROTB: 4

Drug dosage:

Dose	Unit	Route
2	mg	O

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

Property	Description	Value	Unit	Confidence	Similarity
kinase-safety-class	ACVR2B,CDK5,EIF2AK3,GRK2,MAPK7,PDK1,PDK2,PDK4	8
kinase-selectivity-class	AXL,EIF2AK3,GRK2,PDK4,TTK	5
pfas-class	PFAS structural alert (1 = True, 0 = False)	0

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Tongue oedema	59.09	32.64	14	1257	5440	90621736
Altered state of consciousness	53.03	32.64	19	1252	31513	90595663
Intentional overdose	41.45	32.64	22	1249	93812	90533364
Electrocardiogram QT prolonged	40.75	32.64	20	1251	72436	90554740
Suicide attempt	37.07	32.64	19	1252	75380	90551796
Overdose	35.62	32.64	24	1247	157685	90469491

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Patient isolation	47.71	35.96	6	673	43	42620613
Pericarditis	44.88	35.96	14	665	13430	42607226
Suicide attempt	43.79	35.96	19	660	46081	42574575
Pressure of speech	39.59	35.96	7	672	562	42620094

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Altered state of consciousness	68.47	26.85	29	1987	57597	110529686
Suicide attempt	63.59	26.85	33	1983	103361	110483922
Intentional overdose	53.32	26.85	32	1984	132469	110454814
Tongue oedema	49.66	26.85	14	2002	8242	110579041
Patient isolation	44.10	26.85	6	2010	72	110587211
Mallory-Weiss syndrome	41.65	26.85	10	2006	3151	110584132
Irritability	40.51	26.85	19	1997	47790	110539493
Overdose	39.01	26.85	33	1983	233761	110353522
Parkinsonism	36.07	26.85	14	2002	22173	110565110
Hepatic function abnormal	34.42	26.85	21	1995	89274	110498009
Neuroleptic malignant syndrome	33.44	26.85	15	2001	34044	110553239
Electrocardiogram QT prolonged	32.99	26.85	22	1994	108938	110478345
Pressure of speech	32.68	26.85	7	2009	1325	110585958
Alexithymia	30.98	26.85	4	2012	31	110587252

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	N05BA18	NERVOUS SYSTEM PSYCHOLEPTICS ANXIOLYTICS Benzodiazepine derivatives
MeSH PA	D002491	Central Nervous System Agents
MeSH PA	D002492	Central Nervous System Depressants
MeSH PA	D011619	Psychotropic Drugs
MeSH PA	D014149	Tranquilizing Agents
MeSH PA	D014151	Anti-Anxiety Agents
CHEBI has role	CHEBI:35474	anxiolytic drug

Related Drugs by ATC class:

N05BA Benzodiazepine derivatives 23 drugs

adinazolam alprazolam bentazepam bromazepam camazepam chlordiazepoxide clobazam clorazepate clotiazepam cloxazolam diazepam etizolam show all 23 →

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Depressive disorder	indication	35489007
Anxiety	indication	48694002
Myasthenia gravis	contraindication	91637004	DOID:437
Angle-closure glaucoma	contraindication	392291006	DOID:13550

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	9.28	acidic
pKa2	9.89	acidic
pKa3	3.83	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
D01293	KEGG_DRUG
C0059772	UMLSCUI
CHEBI:31573	CHEBI
CHEMBL1213460	ChEMBL_ID
DB01545	DRUGBANK_ID
C029617	MESH_SUPPLEMENTAL_RECORD_UI
3299	PUBCHEM_CID
4837	INN_ID
VJB5FW9W9J	UNII
24524	RXNORM
005857	NDDF
769093001	SNOMEDCT_US
C0099755	UMLSCUI
71735-10-9	SECONDARY_CAS_RN
155667	PUBCHEM_CID
C040581	MESH_SUPPLEMENTAL_RECORD_UI
Y3R871DUQ5	UNII

Pharmaceutical products:

None