clotiazepam 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
diazepam derivatives	718	33671-46-4

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

clotiazepam

Molecular weight: 318.82
Formula: C16H15ClN2OS
CLOGP: 3.03
LIPINSKI: 0
HAC: 3
HDO: 0
TPSA: 32.67
ALOGS: -4.77
ROTB: 2

Drug dosage:

None

ADMET properties:

Property	Value	Reference
BA (Bioavailability)	2.50 %

Predicted pharmacokinetic/toxicological properties (PK-AZ):

Property	Description	Value	Unit	Confidence	Similarity
kinase-selectivity-class	AXL,GRK2	2
kinase-safety-class	ACVR2B,EIF2AK3,GRK2,MAPK10,MAPK7,PDK1,PDK2,PDK4	8
pfas-class	PFAS structural alert (1 = True, 0 = False)	0

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Coma	55.17	34.46	26	1484	72606	90554331
Poisoning	50.65	34.46	16	1494	15201	90611736
Suicide attempt	45.28	34.46	23	1487	75376	90551561
Eczema eyelids	42.50	34.46	7	1503	351	90626586
Toxicity to various agents	41.69	34.46	36	1474	287810	90339127
Inappropriate antidiuretic hormone secretion	39.07	34.46	14	1496	19491	90607446
Somnolence	38.31	34.46	30	1480	209054	90417883
Miosis	35.87	34.46	11	1499	9473	90617464

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Coma	79.28	40.98	33	888	53521	42566893
Drug use disorder	52.71	40.98	16	905	10317	42610097
Gallbladder injury	52.23	40.98	8	913	192	42620222
Monocytosis	41.36	40.98	8	913	771	42619643

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Coma	120.86	28.61	58	2584	117811	110468846
Drug use disorder	72.97	28.61	24	2618	18050	110568607
Somnolence	56.99	28.61	51	2591	297398	110289259
Poisoning	54.78	28.61	22	2620	29083	110557574
Suicide attempt	52.60	28.61	32	2610	103362	110483295
Toxicity to various agents	51.15	28.61	60	2582	480495	110106162
Miosis	39.24	28.61	16	2626	21967	110564690
Eczema eyelids	38.74	28.61	7	2635	420	110586237
Gallbladder injury	36.53	28.61	8	2634	1280	110585377
Monocytosis	34.13	28.61	8	2634	1732	110584925
Stenosis	33.60	28.61	9	2633	3342	110583315
Inappropriate antidiuretic hormone secretion	32.61	28.61	16	2626	33835	110552822
Accidental poisoning	31.29	28.61	8	2634	2479	110584178
Pancreas infection	31.23	28.61	6	2636	503	110586154

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	N05BA21	NERVOUS SYSTEM PSYCHOLEPTICS ANXIOLYTICS Benzodiazepine derivatives
CHEBI has role	CHEBI:35474	anxiolytic drug

Related Drugs by ATC class:

N05BA Benzodiazepine derivatives 23 drugs

adinazolam alprazolam bentazepam bromazepam camazepam chlordiazepoxide clobazam clorazepate cloxazolam diazepam ethyl loflazepate etizolam show all 23 →

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	3.55	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
D01328	KEGG_DRUG
2622	RXNORM
C0009073	UMLSCUI
CHEBI:31425	CHEBI
CHEMBL1697737	ChEMBL_ID
DB01559	DRUGBANK_ID
C084599	MESH_SUPPLEMENTAL_RECORD_UI
2811	PUBCHEM_CID
3496	INN_ID
ZCN055599V	UNII
005796	NDDF
698256004	SNOMEDCT_US

Pharmaceutical products:

None