bromazepam 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
diazepam derivatives 399 1812-30-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • bromazepam
  • durazanil
One of the BENZODIAZEPINES that is used in the treatment of ANXIETY DISORDERS.
  • Molecular weight: 316.16
  • Formula: C14H10BrN3O
  • CLOGP: 1.70
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 54.35
  • ALOGS: -3.90
  • ROTB: 1

Drug dosage:

DoseUnitRoute
10 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.03 mg/mL Bocci G, Oprea TI, Benet LZ
MRTD (Maximum Recommended Therapeutic Daily Dose) 1.36 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 84 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.85 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 0.51 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.48 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 21 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Jan. 1, 1974 YEAR INTRODUCED

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Coma 753.54 17.34 368 17920 63996 63406738
Drug abuse 651.93 17.34 347 17941 72171 63398563
Sopor 479.10 17.34 195 18093 21969 63448765
Poisoning deliberate 402.73 17.34 143 18145 11075 63459659
Toxicity to various agents 280.62 17.34 350 17938 246900 63223834
Intentional overdose 265.12 17.34 198 18090 73954 63396780
Suicide attempt 252.66 17.34 178 18110 60740 63409994
Somnolence 223.64 17.34 266 18022 178419 63292315
Hypotension 172.61 17.34 293 17995 272311 63198423
Bradypnoea 161.30 17.34 54 18234 3496 63467238
Drug use disorder 154.36 17.34 57 18231 4927 63465807
Mydriasis 144.40 17.34 70 18218 11886 63458848
Overdose 141.58 17.34 170 18118 114908 63355826
Altered state of consciousness 138.91 17.34 88 18200 25142 63445592
Hepatocellular injury 129.92 17.34 87 18201 27294 63443440
Electrocardiogram QT prolonged 128.97 17.34 119 18169 59411 63411323
Bradycardia 126.02 17.34 129 18159 73098 63397636
Drug dependence 123.93 17.34 81 18207 24402 63446332
Miosis 123.07 17.34 54 18234 7299 63463435
Hypothermia 121.69 17.34 65 18223 13516 63457218
Drug interaction 120.12 17.34 227 18061 228904 63241830
Poisoning 101.91 17.34 58 18230 13642 63457092
Hyponatraemia 98.16 17.34 140 18148 111760 63358974
Prescription form tampering 95.48 17.34 24 18264 554 63470180
Fall 94.33 17.34 287 18001 392047 63078687
Confusional state 94.03 17.34 209 18079 236171 63234563
Hypokalaemia 91.23 17.34 130 18158 103674 63367060
Pain 87.24 17.34 53 18235 740575 62730159
Toxic epidermal necrolysis 82.35 17.34 64 18224 25270 63445464
Intentional product misuse 79.80 17.34 93 18195 60824 63409910
Intentional self-injury 79.42 17.34 63 18225 25624 63445110
Bradyphrenia 78.69 17.34 39 18249 6941 63463793
Parkinsonism 77.12 17.34 44 18244 10395 63460339
Joint swelling 72.07 17.34 6 18282 327660 63143074
Abdominal discomfort 67.57 17.34 7 18281 320878 63149856
Accidental death 66.38 17.34 24 18264 1952 63468782
Hypoglycaemia 66.15 17.34 84 18204 59981 63410753
Persecutory delusion 65.22 17.34 26 18262 2764 63467970
Toxic skin eruption 63.65 17.34 42 18246 12843 63457891
Psychomotor hyperactivity 63.22 17.34 39 18249 10624 63460110
Cor pulmonale acute 62.86 17.34 16 18272 389 63470345
Respiratory acidosis 62.58 17.34 33 18255 6682 63464052
Drug ineffective 60.12 17.34 133 18155 1044632 62426102
Labelled drug-drug interaction issue 59.09 17.34 19 18269 1082 63469652
Hyperthermia 58.16 17.34 35 18253 9121 63461613
Acute kidney injury 57.89 17.34 187 18101 263228 63207506
Metabolic acidosis 56.02 17.34 67 18221 45002 63425732
Arrhythmia 54.62 17.34 61 18227 38079 63432655
Livedo reticularis 54.55 17.34 22 18266 2410 63468324
Rhabdomyolysis 54.07 17.34 65 18223 43886 63426848
Asphyxia 53.72 17.34 29 18259 6152 63464582
Drug intolerance 53.04 17.34 12 18276 308649 63162085
Coma scale abnormal 52.83 17.34 27 18261 5126 63465608
Respiratory depression 52.00 17.34 38 18250 13677 63457057
Alopecia 50.76 17.34 17 18271 337519 63133215
Agitation 49.77 17.34 73 18215 59684 63411050
Arthropathy 49.72 17.34 5 18283 234787 63235947
Systemic lupus erythematosus 48.27 17.34 3 18285 208915 63261819
Infusion related reaction 47.64 17.34 7 18281 245514 63225220
Nasopharyngitis 47.64 17.34 8 18280 254249 63216485
Rheumatoid arthritis 47.53 17.34 8 18280 253811 63216923
Electrocardiogram QRS complex prolonged 46.48 17.34 26 18262 5912 63464822
Peripheral swelling 46.37 17.34 10 18278 265932 63204802
Drug hypersensitivity 46.10 17.34 16 18272 310671 63160063
Dermatitis exfoliative 45.74 17.34 25 18263 5434 63465300
Hepatitis acute 45.71 17.34 30 18258 9090 63461644
Treatment failure 45.56 17.34 3 18285 199040 63271694
Cholestasis 45.48 17.34 49 18239 29385 63441349
Vertigo 45.37 17.34 70 18218 59817 63410917
Swelling 44.78 17.34 12 18276 275366 63195368
Pneumonia aspiration 43.99 17.34 52 18236 34488 63436246
Sinusitis 42.75 17.34 7 18281 226646 63244088
Product dose omission issue 42.53 17.34 8 18280 234305 63236429
Hepatitis toxic 42.16 17.34 20 18268 3233 63467501
Loss of consciousness 41.95 17.34 100 18188 118021 63352713
Autoimmune haemolytic anaemia 41.14 17.34 22 18266 4579 63466155
Arthralgia 41.07 17.34 63 18225 569647 62901087
Rash 40.45 17.34 62 18226 560809 62909925
Contraindicated product administered 40.43 17.34 7 18281 217641 63253093
Sinus tachycardia 40.34 17.34 42 18246 24226 63446508
Extrapyramidal disorder 39.81 17.34 32 18256 13252 63457482
Sinoatrial block 38.33 17.34 13 18275 875 63469859
Thymus disorder 37.57 17.34 10 18278 291 63470443
Vasoplegia syndrome 36.84 17.34 15 18273 1684 63469050
Cross sensitivity reaction 36.57 17.34 16 18272 2146 63468588
Psychiatric decompensation 36.06 17.34 14 18274 1387 63469347
Postmortem blood drug level abnormal 35.85 17.34 10 18278 348 63470386
Housebound 35.12 17.34 9 18279 225 63470509
Ventricular dyskinesia 34.83 17.34 8 18280 124 63470610
Cardiogenic shock 33.39 17.34 33 18255 17899 63452835
Salivary hypersecretion 33.12 17.34 23 18265 7643 63463091
Hyperthyroidism 33.04 17.34 30 18258 14643 63456091
Tremor 32.80 17.34 98 18190 132141 63338593
Depressed level of consciousness 31.79 17.34 61 18227 62017 63408717
Inappropriate antidiuretic hormone secretion 31.70 17.34 30 18258 15432 63455302
Prevertebral soft tissue swelling of cervical space 31.25 17.34 6 18282 36 63470698
Bradykinesia 30.81 17.34 19 18269 5169 63465565
Drug reaction with eosinophilia and systemic symptoms 30.60 17.34 43 18245 33793 63436941
Alcohol abuse 30.30 17.34 14 18274 2132 63468602
Disturbance in attention 29.43 17.34 45 18243 38144 63432590
Headache 29.06 17.34 90 18198 633151 62837583
Wrong rate 29.02 17.34 6 18282 55 63470679
Bundle branch block right 28.91 17.34 18 18270 4980 63465754
Hyperchloraemia 28.40 17.34 10 18278 753 63469981
Disorientation 28.32 17.34 45 18243 39407 63431327
Eczema eyelids 28.21 17.34 7 18281 153 63470581
Cholecystitis 28.08 17.34 28 18260 15349 63455385
Suicidal ideation 27.95 17.34 58 18230 62363 63408371
Discomfort 27.75 17.34 7 18281 167367 63303367
Fear of weight gain 27.72 17.34 5 18283 20 63470714
Sinus bradycardia 27.50 17.34 27 18261 14524 63456210
Hepatic enzyme increased 27.38 17.34 12 18276 202316 63268418
Hypoosmolar state 26.94 17.34 7 18281 185 63470549
Eosinophilia 26.91 17.34 33 18255 22723 63448011
Fatigue 26.59 17.34 149 18139 887879 62582855
Lactic acidosis 26.57 17.34 43 18245 38244 63432490
Leukocytosis 26.54 17.34 35 18253 25900 63444834
Growth disorder 26.49 17.34 5 18283 27 63470707
Pneumonia 26.21 17.34 58 18230 456709 63014025
Cutaneous T-cell lymphoma 25.93 17.34 11 18277 1369 63469365
Myoglobin blood increased 25.74 17.34 11 18277 1394 63469340
Haemolytic anaemia 25.38 17.34 22 18266 10103 63460631
Nystagmus 25.33 17.34 18 18270 6202 63464532
Serotonin syndrome 25.27 17.34 36 18252 28646 63442088
Haemodynamic instability 25.15 17.34 21 18267 9169 63461565
Electrocardiogram QRS complex shortened 24.79 17.34 8 18280 461 63470273
Hypersensitivity 24.44 17.34 29 18259 292656 63178078
Agranulocytosis 24.32 17.34 33 18255 25101 63445633
Patella fracture 24.11 17.34 12 18276 2154 63468580
Antipsychotic drug level increased 24.09 17.34 14 18274 3421 63467313
Cholinergic syndrome 24.01 17.34 8 18280 510 63470224
Epilepsy 23.89 17.34 34 18254 27031 63443703
Bronchospasm 23.65 17.34 27 18261 17253 63453481
Pain in extremity 23.50 17.34 37 18251 331449 63139285
Cardiorenal syndrome 23.43 17.34 9 18279 866 63469868
Infection 23.41 17.34 19 18269 229154 63241580
Tonic convulsion 23.25 17.34 10 18278 1287 63469447
Acute pulmonary oedema 23.07 17.34 19 18269 8139 63462595
Lower respiratory tract infection 22.99 17.34 5 18283 132302 63338432
Dermatitis exfoliative generalised 22.76 17.34 14 18274 3793 63466941
Stress cardiomyopathy 22.62 17.34 20 18268 9430 63461304
Psychomotor retardation 22.55 17.34 14 18274 3856 63466878
Nasal mucosal erosion 22.31 17.34 5 18283 69 63470665
Hypercapnic coma 21.96 17.34 6 18282 193 63470541
Malignant catatonia 21.93 17.34 6 18282 194 63470540
Contusion 21.76 17.34 8 18280 150036 63320698
Mucosal erosion 21.75 17.34 10 18278 1506 63469228
Violence-related symptom 21.73 17.34 7 18281 401 63470333
Generalised anxiety disorder 21.64 17.34 11 18277 2063 63468671
Wound 21.58 17.34 10 18278 163253 63307481
Chronic fatigue syndrome 21.30 17.34 9 18279 1109 63469625
Multiple organ dysfunction syndrome 21.17 17.34 49 18239 56703 63414031
Platelet count decreased 20.98 17.34 4 18284 116118 63354616
Drug level increased 20.71 17.34 29 18259 22707 63448027
Cerebral haematoma 20.64 17.34 13 18275 3670 63467064
Musculoskeletal stiffness 20.54 17.34 14 18274 184604 63286130
Drug screen false positive 19.84 17.34 8 18280 876 63469858
Substance abuse 19.78 17.34 14 18274 4793 63465941
Rash scarlatiniform 19.74 17.34 5 18283 119 63470615
Rash maculo-papular 19.69 17.34 34 18254 31862 63438872
Cough 19.51 17.34 34 18254 292709 63178025
Status epilepticus 19.50 17.34 23 18265 15210 63455524
Eczema 19.39 17.34 34 18254 32257 63438477
Cell death 19.31 17.34 11 18277 2590 63468144
Muscle rigidity 19.28 17.34 20 18268 11480 63459254
White blood cell count decreased 19.21 17.34 8 18280 139096 63331638
Occupational dermatitis 19.12 17.34 4 18284 39 63470695
Cardiac output decreased 19.10 17.34 8 18280 964 63469770
Hypotonia 19 17.34 18 18270 9267 63461467
Cardiac failure acute 18.61 17.34 18 18270 9505 63461229
Circulatory collapse 18.54 17.34 27 18261 21911 63448823
Torsade de pointes 18.50 17.34 21 18267 13330 63457404
Labelled drug-disease interaction issue 18.44 17.34 4 18284 47 63470687
Craniocerebral injury 18.44 17.34 11 18277 2821 63467913
Pyramidal tract syndrome 18.40 17.34 6 18282 357 63470377
Tachycardia 18.34 17.34 75 18213 118081 63352653
Product use issue 18.24 17.34 22 18266 220498 63250236
Maternal exposure during pregnancy 18.15 17.34 22 18266 220040 63250694
Hallucination 17.94 17.34 45 18243 54772 63415962
Wheezing 17.90 17.34 3 18285 95592 63375142
Osteoarthritis 17.84 17.34 3 18285 95340 63375394
Haemoglobin decreased 17.61 17.34 10 18278 145475 63325259
Psychomotor skills impaired 17.54 17.34 10 18278 2358 63468376
Ventricular tachycardia 17.49 17.34 25 18263 19954 63450780
Electrolyte imbalance 17.39 17.34 25 18263 20051 63450683

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Coma 450.15 19.88 237 10461 45441 34900792
Drug abuse 351.16 19.88 269 10429 98827 34847406
Poisoning deliberate 268.34 19.88 98 10600 7746 34938487
Toxicity to various agents 187.64 19.88 266 10432 200096 34746137
Somnolence 179.03 19.88 194 10504 110922 34835311
Drug dependence 139.95 19.88 89 10609 24128 34922105
Mydriasis 127.24 19.88 56 10642 7181 34939052
Sopor 119.23 19.88 63 10635 12073 34934160
Intentional overdose 112.95 19.88 99 10599 43575 34902658
Miosis 103.70 19.88 53 10645 9482 34936751
Poisoning 96.70 19.88 55 10643 12171 34934062
Altered state of consciousness 89.20 19.88 66 10632 22827 34923406
Hypothermia 81.38 19.88 47 10651 10701 34935532
Pneumonia aspiration 81.34 19.88 81 10617 41822 34904411
Suicide attempt 80.37 19.88 78 10620 39038 34907195
Intentional product misuse 79.15 19.88 83 10615 45528 34900705
Drug use disorder 78.77 19.88 34 10664 4157 34942076
Asphyxia 65.75 19.88 35 10663 6800 34939433
Visceral congestion 63.86 19.88 18 10680 612 34945621
Substance abuse 56.74 19.88 33 10665 7608 34938625
Withdrawal syndrome 55.56 19.88 39 10659 12416 34933817
Drug ineffective 55.45 19.88 36 10662 456715 34489518
Agitation 53.05 19.88 76 10622 57323 34888910
Lactic acidosis 51.10 19.88 58 10640 34714 34911519
Mucosal dryness 50.62 19.88 18 10680 1313 34944920
Prescription form tampering 50.37 19.88 14 10684 452 34945781
Oral discharge 50.08 19.88 11 10687 129 34946104
Bradypnoea 50.06 19.88 22 10676 2807 34943426
Overdose 48.36 19.88 94 10604 90965 34855268
Depressed level of consciousness 47.55 19.88 62 10636 42779 34903454
Confusional state 45.48 19.88 121 10577 144039 34802194
Intestinal atony 44.72 19.88 8 10690 28 34946205
Vertigo 43.42 19.88 46 10652 25490 34920743
Housebound 39.30 19.88 10 10688 228 34946005
Cluster headache 39.04 19.88 12 10686 554 34945679
Bradycardia 37.79 19.88 76 10622 75342 34870891
Brain oedema 37.02 19.88 32 10666 13789 34932444
Left atrial dilatation 36.87 19.88 16 10682 1980 34944253
Lichenoid keratosis 36.44 19.88 17 10681 2491 34943742
Vascular stenosis 36.35 19.88 9 10689 183 34946050
Haematocrit increased 35.99 19.88 16 10682 2097 34944136
Laryngeal dyspnoea 35.80 19.88 8 10690 102 34946131
Hyperthermia 35.68 19.88 28 10670 10549 34935684
Hypovolaemia 34.55 19.88 26 10672 9208 34937025
Incorrect product administration duration 33.67 19.88 20 10678 4791 34941442
Pneumonia 33.59 19.88 37 10661 362590 34583643
Amyotrophy 32.22 19.88 10 10688 477 34945756
Hepatocellular injury 30.85 19.88 36 10662 22175 34924058
Brief psychotic disorder with marked stressors 29.90 19.88 8 10690 223 34946010
Psychomotor skills impaired 29.34 19.88 17 10681 3889 34942344
Alcohol abuse 28.97 19.88 18 10680 4672 34941561
Haemoglobin increased 28.74 19.88 16 10682 3393 34942840
Bradyphrenia 28.59 19.88 18 10680 4780 34941453
Wrong drug 26.67 19.88 6 10692 79 34946154
Product dose omission issue 26.18 19.88 3 10695 119708 34826525
Phlebotomy 25.76 19.88 6 10692 93 34946140
Parotid gland haemorrhage 25.74 19.88 5 10693 30 34946203
Ischaemic hepatitis 25.35 19.88 12 10686 1816 34944417
Cerebrovascular stenosis 25.19 19.88 6 10692 103 34946130
Ureteric haemorrhage 24.82 19.88 6 10692 110 34946123
Kounis syndrome 24.51 19.88 13 10685 2505 34943728
Anal haemorrhage 24.22 19.88 13 10685 2565 34943668
Systolic hypertension 24.01 19.88 7 10691 269 34945964
Acute pulmonary oedema 23.82 19.88 19 10679 7324 34938909
Disturbance in attention 23.42 19.88 34 10664 25911 34920322
Behaviour disorder 23.36 19.88 16 10682 4894 34941339
Psychomotor hyperactivity 23.22 19.88 21 10677 9601 34936632
Acute kidney injury 23.17 19.88 166 10532 304822 34641411
Anxiety disorder due to a general medical condition 23.09 19.88 4 10694 11 34946222
Loss of consciousness 22.66 19.88 66 10632 82601 34863632
Respiratory depression 22.01 19.88 26 10672 16219 34930014
Squamous cell carcinoma 21.90 19.88 22 10676 11453 34934780
Victim of crime 21.75 19.88 7 10691 376 34945857
Sepsis 21.69 19.88 12 10686 166549 34779684
Arthralgia 21.08 19.88 13 10685 170028 34776205
Peripheral sensorimotor neuropathy 20.77 19.88 10 10688 1572 34944661
Subdural haematoma 20.26 19.88 28 10670 20393 34925840
Presyncope 20.23 19.88 27 10671 19032 34927201
Hypotension 20.02 19.88 126 10572 221523 34724710

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Coma 1135.18 15.53 598 27370 100051 79616369
Drug abuse 834.00 15.53 583 27385 162108 79554312
Poisoning deliberate 615.54 15.53 236 27732 18592 79697828
Sopor 552.37 15.53 257 27711 32753 79683667
Toxicity to various agents 397.69 15.53 604 27364 420936 79295484
Somnolence 379.04 15.53 442 27526 238539 79477881
Intentional overdose 315.60 15.53 276 27692 105684 79610736
Suicide attempt 300.62 15.53 242 27726 82690 79633730
Mydriasis 254.15 15.53 124 27844 17519 79698901
Drug use disorder 221.66 15.53 91 27877 8560 79707860
Miosis 212.62 15.53 106 27862 15683 79700737
Altered state of consciousness 212.01 15.53 152 27816 43670 79672750
Bradypnoea 194.58 15.53 75 27893 5977 79710443
Hypothermia 192.06 15.53 112 27856 22634 79693786
Drug dependence 178.17 15.53 133 27835 40636 79675784
Poisoning 176.09 15.53 110 27858 25162 79691258
Overdose 157.61 15.53 253 27715 183953 79532467
Hypotension 140.07 15.53 404 27564 439913 79276507
Hepatocellular injury 139.56 15.53 123 27845 47470 79668950
Bradycardia 138.19 15.53 202 27766 135355 79581065
Confusional state 136.03 15.53 326 27642 317671 79398749
Intentional product misuse 135.59 15.53 167 27801 94998 79621422
Pneumonia aspiration 116.13 15.53 130 27838 66837 79649583
Electrocardiogram QT prolonged 105.87 15.53 144 27824 90242 79626178
Fall 100.90 15.53 387 27581 487242 79229178
Bradyphrenia 99.46 15.53 56 27912 10584 79705836
Agitation 96.41 15.53 145 27823 99570 79616850
Intentional self-injury 95.45 15.53 84 27884 32335 79684085
Drug ineffective 87.28 15.53 154 27814 1080759 78635661
Drug interaction 85.39 15.53 329 27639 414854 79301566
Vertigo 85.37 15.53 113 27855 68969 79647451
Pain 83.03 15.53 75 27893 703727 79012693
Asphyxia 81.58 15.53 51 27917 11669 79704751
Hyperthermia 79.12 15.53 59 27909 17978 79698442
Psychomotor hyperactivity 78.15 15.53 57 27911 16792 79699628
Joint swelling 73.09 15.53 8 27960 288638 79427782
Substance abuse 71.25 15.53 45 27923 10481 79705939
Housebound 71.13 15.53 19 27949 457 79715963
Hyponatraemia 70.22 15.53 177 27791 177671 79538749
Depressed level of consciousness 68.28 15.53 122 27846 96530 79619890
Parkinsonism 65.58 15.53 51 27917 16533 79699887
Lactic acidosis 64.71 15.53 100 27868 70259 79646161
Hypokalaemia 63.94 15.53 150 27818 143890 79572530
Abdominal discomfort 63.34 15.53 7 27961 250720 79465700
Acute kidney injury 61.89 15.53 351 27617 519053 79197367
Pneumonia 58.79 15.53 88 27880 660158 79056262
Peripheral swelling 57.91 15.53 12 27956 269605 79446815
Hypoglycaemia 57.86 15.53 117 27851 101477 79614943
Arthralgia 57.17 15.53 70 27898 571733 79144687
Drug hypersensitivity 57.05 15.53 17 27951 298899 79417521
Rhabdomyolysis 56.64 15.53 117 27851 103014 79613406
Loss of consciousness 55.99 15.53 157 27811 167786 79548634
Cor pulmonale acute 55.39 15.53 17 27951 679 79715741
Accidental death 55.37 15.53 28 27940 4263 79712157
Product dose omission issue 55.31 15.53 10 27958 247527 79468893
Persecutory delusion 54.63 15.53 29 27939 4880 79711540
Visceral congestion 54.04 15.53 18 27950 938 79715482
Toxic skin eruption 52.49 15.53 51 27917 22242 79694178
Drug intolerance 52.29 15.53 14 27954 264105 79452315
Alcohol abuse 52.23 15.53 29 27939 5334 79711086
Rheumatoid arthritis 52.19 15.53 6 27962 208464 79507956
Prescription form tampering 50.87 15.53 14 27954 378 79716042
Respiratory acidosis 49.93 15.53 37 27931 11163 79705257
Bradykinesia 48.55 15.53 32 27936 8011 79708409
Respiratory depression 48.49 15.53 54 27914 27576 79688844
Extrapyramidal disorder 48.07 15.53 49 27919 22630 79693790
Arrhythmia 48.03 15.53 81 27887 61191 79655229
Infusion related reaction 47.91 15.53 11 27957 230226 79486194
Toxic epidermal necrolysis 47.64 15.53 68 27900 44513 79671907
Labelled drug-drug interaction issue 47.17 15.53 18 27950 1395 79715025
Therapeutic product effect decreased 45.67 15.53 3 27965 163860 79552560
Sinusitis 45.66 15.53 7 27961 195494 79520926
Mucosal dryness 45.27 15.53 23 27945 3536 79712884
Psychomotor skills impaired 44.75 15.53 26 27942 5211 79711209
Arthropathy 44.58 15.53 5 27963 177106 79539314
Amyotrophy 44.53 15.53 14 27954 606 79715814
Sinus bradycardia 43.72 15.53 49 27919 25198 79691222
Incorrect product administration duration 43.31 15.53 35 27933 11987 79704433
Livedo reticularis 42.19 15.53 23 27945 4080 79712340
Intestinal atony 41.84 15.53 8 27960 37 79716383
Oral discharge 41.48 15.53 11 27957 257 79716163
Alopecia 40.90 15.53 15 27953 231340 79485080
Inappropriate antidiuretic hormone secretion 40.40 15.53 48 27920 26265 79690155
Pain in extremity 40.36 15.53 41 27927 364497 79351923
Hepatitis toxic 39.91 15.53 24 27944 5123 79711297
Withdrawal syndrome 39.62 15.53 48 27920 26806 79689614
Hepatitis acute 39.33 15.53 37 27931 15505 79700915
Suicidal ideation 38.88 15.53 84 27884 76256 79640164
Swelling 38.39 15.53 14 27954 216697 79499723
Tremor 38.35 15.53 139 27829 169944 79546476
Disturbance in attention 38.29 15.53 66 27902 50735 79665685
Dermatitis exfoliative 37.90 15.53 31 27937 10798 79705622
Treatment failure 37.83 15.53 7 27961 170479 79545941
Sinoatrial block 37.30 15.53 15 27953 1336 79715084
Platelet count decreased 37.25 15.53 11 27957 194653 79521767
White blood cell count decreased 37.22 15.53 10 27958 188278 79528142
Tonic convulsion 36.20 15.53 17 27951 2203 79714217
Cholestasis 35.79 15.53 65 27903 52044 79664376
Thymus disorder 35.75 15.53 10 27958 287 79716133
Fatigue 35.45 15.53 187 27781 929540 78786880
Brain oedema 35.40 15.53 44 27924 25219 79691201
Coma scale abnormal 34.99 15.53 27 27941 8651 79707769
Rash 34.49 15.53 97 27871 578261 79138159
Cluster headache 34.37 15.53 13 27955 983 79715437
Haemodynamic instability 34.04 15.53 36 27932 17346 79699074
Electrocardiogram QRS complex prolonged 33.75 15.53 29 27939 10804 79705616
Cardiac failure congestive 33.47 15.53 5 27963 142397 79574023
Metabolic acidosis 33.43 15.53 83 27885 82446 79633974
Drug reaction with eosinophilia and systemic symptoms 33.06 15.53 71 27897 64173 79652247
Cerebral haematoma 32.66 15.53 25 27943 7917 79708503
Apraxia 32.08 15.53 17 27951 2850 79713570
Systemic lupus erythematosus 31.57 15.53 3 27965 121146 79595274
Pulmonary congestion 31.43 15.53 43 27925 27057 79689363
Headache 31.16 15.53 121 27847 653651 79062769
Haemoglobin decreased 30.77 15.53 20 27948 222099 79494321
Prevertebral soft tissue swelling of cervical space 30.07 15.53 6 27962 36 79716384
Lower respiratory tract infection 29.33 15.53 5 27963 129215 79587205
Infection 29.31 15.53 25 27943 241687 79474733
Salivary hypersecretion 28.82 15.53 30 27938 14194 79702226
Cough 28.75 15.53 53 27915 366736 79349684
Postmortem blood drug level abnormal 27.98 15.53 10 27958 644 79715776
Left atrial dilatation 27.86 15.53 16 27952 3137 79713283
Disease progression 27.79 15.53 15 27953 184347 79532073
Hypotonia 27.63 15.53 28 27940 12842 79703578
Nasopharyngitis 27.57 15.53 29 27939 253852 79462568
Disorientation 27.42 15.53 65 27903 62711 79653709
Cardiogenic shock 27.17 15.53 51 27917 41863 79674557
Aggression 27.01 15.53 57 27911 50901 79665519
Fear of weight gain 26.94 15.53 5 27963 19 79716401
Hyperthyroidism 26.91 15.53 36 27932 22173 79694247
Laryngeal dyspnoea 26.73 15.53 8 27960 293 79716127
Wrong rate 26.69 15.53 6 27962 68 79716352
Toxic encephalopathy 26.61 15.53 26 27942 11414 79705006
Brief psychotic disorder with marked stressors 26.52 15.53 8 27960 301 79716119
Dyspnoea 26.52 15.53 184 27784 856841 78859579
Purpura 25.75 15.53 33 27935 19494 79696926
Eczema eyelids 25.61 15.53 7 27961 184 79716236
Orthostatic hypotension 25.45 15.53 59 27909 56105 79660315
Cross sensitivity reaction 25.45 15.53 16 27952 3696 79712724
Acute pulmonary oedema 25.29 15.53 28 27940 14202 79702218
Urinary retention 25.13 15.53 59 27909 56571 79659849
Vascular stenosis 24.93 15.53 9 27959 597 79715823
Parotid gland haemorrhage 24.92 15.53 5 27963 31 79716389
Growth disorder 24.78 15.53 5 27963 32 79716388
Phlebotomy 24.54 15.53 6 27962 100 79716320
Ventricular dyskinesia 24.33 15.53 8 27960 400 79716020
Haematocrit increased 24.23 15.53 16 27952 4018 79712402
Lichenoid keratosis 24.15 15.53 16 27952 4041 79712379
Behaviour disorder 24.06 15.53 19 27949 6294 79710126
Occupational exposure to product 23.66 15.53 9 27959 691 79715729
Vasoplegia syndrome 23.28 15.53 15 27953 3615 79712805
Autoimmune haemolytic anaemia 23.24 15.53 21 27947 8359 79708061
Hepatic enzyme increased 23.24 15.53 18 27950 182592 79533828
Patella fracture 23.23 15.53 12 27956 1909 79714511
Eosinophilia 23.20 15.53 50 27918 45295 79671125
Oropharyngeal pain 23.19 15.53 5 27963 109348 79607072
Hyperchloraemia 22.76 15.53 10 27958 1111 79715309
Contusion 22.57 15.53 12 27956 148764 79567656
Tachycardia 22.31 15.53 122 27846 177646 79538774
Phlebitis 22.30 15.53 21 27947 8809 79707611
Hypersensitivity 22.26 15.53 36 27932 262203 79454217
Psychiatric decompensation 22.08 15.53 15 27953 3948 79712472
Cerebrovascular stenosis 21.94 15.53 6 27962 158 79716262
Anxiety disorder due to a general medical condition 21.81 15.53 4 27964 14 79716406
Delusion 21.59 15.53 31 27937 20392 79696028
Sinus tachycardia 21.58 15.53 43 27925 36865 79679555
Hypoosmolar state 21.49 15.53 7 27961 340 79716080
Nasal mucosal erosion 21.33 15.53 5 27963 69 79716351
Anal haemorrhage 21.18 15.53 15 27953 4219 79712201
Injection site pain 20.40 15.53 10 27958 129828 79586592
Asthma 20.34 15.53 11 27957 135084 79581336
Urinary tract infection 20.33 15.53 41 27927 274471 79441949
Psychomotor retardation 20.18 15.53 17 27951 6167 79710253
Hypercapnic coma 20.11 15.53 7 27961 417 79716003
Wheezing 19.88 15.53 8 27960 116656 79599764
Respiratory distress 19.87 15.53 55 27913 58284 79658136
Electrocardiogram QRS complex shortened 19.79 15.53 8 27960 722 79715698
Gastrooesophageal reflux disease 19.74 15.53 6 27962 104240 79612180
Back pain 19.62 15.53 49 27919 304131 79412289
Status epilepticus 19.48 15.53 33 27935 25008 79691412
COVID-19 treatment 19.41 15.53 7 27961 463 79715957
Arthritis 19.38 15.53 8 27960 114872 79601548
Sepsis 19.31 15.53 41 27927 269387 79447033
Therapeutic product effect incomplete 19.27 15.53 13 27955 141632 79574788
Loss of personal independence in daily activities 19.25 15.53 6 27962 102574 79613846
Victim of crime 19.15 15.53 7 27961 481 79715939
Generalised anxiety disorder 19.02 15.53 11 27957 2186 79714234
Hypovolaemia 18.92 15.53 27 27941 17664 79698756
Shock 18.91 15.53 45 27923 43503 79672917
Drug diversion 18.64 15.53 9 27959 1241 79715179
Presyncope 18.46 15.53 43 27925 41011 79675409
Wrong drug 18.45 15.53 6 27962 290 79716130
Craniocerebral injury 18.44 15.53 15 27953 5181 79711239
Hallucination, auditory 18.44 15.53 29 27939 20664 79695756
Hypertensive crisis 18.36 15.53 29 27939 20741 79695679
Lung disorder 18.28 15.53 66 27902 80491 79635929
Haemoglobin increased 18.26 15.53 16 27952 6116 79710304
Rash maculo-papular 18.24 15.53 52 27916 56026 79660394
Stress 18.24 15.53 3 27965 79609 79636811
Chronic fatigue syndrome 18.00 15.53 9 27959 1338 79715082
Musculoskeletal stiffness 17.89 15.53 21 27947 174987 79541433
Labelled drug-disease interaction issue 17.66 15.53 4 27964 47 79716373
Blood creatinine increased 17.64 15.53 17 27951 155040 79561380
Product use issue 17.62 15.53 29 27939 209793 79506627
Ischaemic stroke 17.49 15.53 37 27931 33094 79683326
Anaphylactic reaction 17.41 15.53 4 27964 83739 79632681
Blood cholesterol increased 17.40 15.53 4 27964 83716 79632704
Pemphigoid 17.31 15.53 24 27944 15291 79701129
Contraindicated product administered 17.09 15.53 18 27950 157520 79558900
Cholecystitis 16.92 15.53 29 27939 22183 79694237
Cutaneous T-cell lymphoma 16.91 15.53 11 27957 2692 79713728
Cyanosis 16.77 15.53 31 27937 25151 79691269
Nystagmus 16.76 15.53 19 27949 9885 79706535
Cholinergic syndrome 16.73 15.53 8 27960 1079 79715341
Dysarthria 16.72 15.53 57 27911 67565 79648855
Nausea 16.72 15.53 236 27732 956960 78759460
Maternal exposure during pregnancy 16.69 15.53 14 27954 136524 79579896
Sudden death 16.63 15.53 29 27939 22482 79693938
Systolic hypertension 16.62 15.53 7 27961 701 79715719
Cardiorenal syndrome 16.60 15.53 9 27959 1580 79714840
Drug screen false positive 16.58 15.53 8 27960 1101 79715319
Kounis syndrome 16.56 15.53 13 27955 4269 79712151
Stress cardiomyopathy 16.53 15.53 20 27948 11146 79705274
Subdural haematoma 16.47 15.53 35 27933 31399 79685021
Bundle branch block right 16.41 15.53 20 27948 11231 79705189
Therapy non-responder 16.27 15.53 6 27962 92299 79624121
Cellulitis 16.24 15.53 9 27959 109051 79607369
Conjunctival hyperaemia 16.22 15.53 13 27955 4400 79712020
Ischaemic hepatitis 16.10 15.53 12 27956 3652 79712768
Off label use 16.08 15.53 223 27745 906992 78809428
Restlessness 16.00 15.53 44 27924 46448 79669972
Haemolytic anaemia 15.91 15.53 25 27943 17795 79698625
Mucosal erosion 15.91 15.53 10 27958 2308 79714112
Injection site erythema 15.73 15.53 4 27964 78193 79638227
Mobility decreased 15.59 15.53 12 27956 122163 79594257

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N05BA08 NERVOUS SYSTEM
PSYCHOLEPTICS
ANXIOLYTICS
Benzodiazepine derivatives
MeSH PA D014151 Anti-Anxiety Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D018682 GABA Agents
MeSH PA D018757 GABA Modulators
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D011619 Psychotropic Drugs
MeSH PA D014149 Tranquilizing Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.29 acidic
pKa2 3.26 Basic
pKa3 2.58 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
GABA-A receptor alpha-1/beta-2/gamma-2 Ion channel WOMBAT-PK

External reference:

IDSource
N0000166922 NUI
D01245 KEGG_DRUG
1749 RXNORM
C0006213 UMLSCUI
CHEBI:31302 CHEBI
CHEMBL277062 ChEMBL_ID
DB01558 DRUGBANK_ID
D001960 MESH_DESCRIPTOR_UI
2441 PUBCHEM_CID
2692 INN_ID
X015L14V0O UNII
11834 MMSL
387571009 SNOMEDCT_US
96234002 SNOMEDCT_US
003512 NDDF

Pharmaceutical products:

None