AI ASSISTANT
Ask DrugCentral
Explore drug properties, targets, and indications with answers grounded in DrugCentral.
Powered by DrugCentral + retrieval-augmented AIYour question
Ask in your own words. Each question is answered independently.
Explore sample questions
Select a question to fill the editor, then ask it or make it your own.
DrugCentral answer
Your answer will appear here. Open linked drug cards in a new tab to explore the source details.
About Ask DrugCentral
Ask DrugCentral helps you explore drug properties, biological targets, and indications using natural language. Sample questions offer starting points, and linked drug cards let you check the underlying records.
General architecture
- Ask a questionThe browser sends your question to the same-origin Django chat API.
- Retrieve and generateThe API forwards the question to the configured DrugCentral retrieval-augmented generation (RAG) service, which returns an AI-generated answer.
- Explore the answerThe app resolves cited drug-card names and displays the answer with links to drug records.
Using the assistant
Each request is independent; previous questions are not sent as conversation history. You can edit a sample before submitting, retry a failed request, or switch back to normal search. Drug links open in a new tab so your question and answer stay available.
Answers may contain mistakes or omit information. Verify details against DrugCentral records and original sources.
AI can make mistakes. Verify answers against the original sources before relying on them.
bromazepam 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| diazepam derivatives | 399 | 1812-30-2 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
One of the BENZODIAZEPINES that is used in the treatment of ANXIETY DISORDERS.
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 10 | mg | O |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
| S (Water solubility) | 0.03 mg/mL | Bocci G, Oprea TI, Benet LZ |
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 1.36 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
| BA (Bioavailability) | 84 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
| Vd (Volume of distribution) | 0.85 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 0.51 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| fu (Fraction unbound in plasma) | 0.48 % | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 21 hours | Lombardo F, Berellini G, Obach RS |
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| azlogd74 | LogD at pH 7.4 | 2.048 | Moderate | 0.65 | |
| caco2-efflux | Caco-2 efflux ratio (BA/AB) | 0.705 | Moderate | 0.65 | |
| caco2-intrinsic-papp | Caco-2 intrinsic apparent permeability | 77.446 | 10^-6 cm/s | Moderate | 0.65 |
| dh-clint | Dog hepatocyte intrinsic clearance | 24.044 | uL/min/10^6 cells | Moderate | 0.65 |
| dppb | Dog plasma protein binding (% unbound) | 21.990 | % | Moderate | 0.65 |
| fcs-ppb | Fetal calf serum protein binding (% unbound) | 40.890 | % | Moderate | 0.65 |
| herg | hERG pIC50 | 4.152 | pIC50 | Moderate | 0.65 |
| hh-clint | Human hepatocyte intrinsic clearance | 3.936 | uL/min/10^6 cells | Moderate | 0.65 |
| hlm-clint | Human liver microsomal intrinsic clearance | 12.359 | uL/min/mg protein | Moderate | 0.65 |
| hppb | Human plasma protein binding (% unbound) | 30.780 | % | Moderate | 0.65 |
| kinase-safety-class | EIF2AK3,GRK2,PDK1,PDK2,PDK4 | 5 | |||
| kinase-selectivity-class | GRK2 | 1 | |||
| mdck-mdr1-efflux | MDCK-MDR1 efflux ratio | 1.012 | Moderate | 0.65 | |
| mh-clint | Mouse hepatocyte intrinsic clearance | 19.055 | Moderate | 0.65 | |
| mppb | Mouse plasma protein binding (% unbound) | 29.950 | Moderate | 0.65 | |
| nih-mdck-mdr1-efflux | NIH MDCK-MDR1 efflux ratio | 0.912 | Moderate | 0.65 | |
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 | |||
| pppb | Pig plasma protein binding (% unbound) | 32.770 | % | Moderate | 0.65 |
| rh-clint | Rat hepatocyte intrinsic clearance | 19.770 | uL/min/10^6 cells | Moderate | 0.65 |
| rh-fuinc | Rat hepatocyte fraction unbound in incubation | 85.340 | % | Moderate | 0.65 |
| rppb | Rat plasma protein binding (% unbound) | 29.330 | % | Moderate | 0.65 |
| solubility-dd | Solubility at pH 7.4 in DMSO | 193.642 | uM | Moderate | 0.65 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Jan. 1, 1974 | YEAR INTRODUCED |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Coma | 1003.56 | 17.05 | 450 | 22909 | 72182 | 90532906 |
| Drug abuse | 955.68 | 17.05 | 452 | 22907 | 81895 | 90523193 |
| Poisoning deliberate | 757.92 | 17.05 | 246 | 23113 | 16240 | 90588848 |
| Drug use disorder | 650.93 | 17.05 | 187 | 23172 | 8156 | 90596932 |
| Sopor | 545.97 | 17.05 | 214 | 23145 | 24430 | 90580658 |
| Toxicity to various agents | 495.86 | 17.05 | 481 | 22878 | 287365 | 90317723 |
| Intentional overdose | 438.72 | 17.05 | 283 | 23076 | 93551 | 90511537 |
| Somnolence | 381.52 | 17.05 | 361 | 22998 | 208723 | 90396365 |
| Suicide attempt | 351.31 | 17.05 | 227 | 23132 | 75172 | 90529916 |
| Drug interaction | 257.85 | 17.05 | 336 | 23023 | 276117 | 90328971 |
| Hypotension | 241.22 | 17.05 | 354 | 23005 | 325043 | 90280045 |
| Altered state of consciousness | 211.47 | 17.05 | 120 | 23239 | 31412 | 90573676 |
| Miosis | 208.64 | 17.05 | 82 | 23277 | 9402 | 90595686 |
| Mydriasis | 197.24 | 17.05 | 90 | 23269 | 14922 | 90590166 |
| Bradypnoea | 187.78 | 17.05 | 63 | 23296 | 4595 | 90600493 |
| Drug dependence | 181.68 | 17.05 | 106 | 23253 | 29221 | 90575867 |
| Hyponatraemia | 172.98 | 17.05 | 192 | 23167 | 133346 | 90471742 |
| Poisoning | 171.34 | 17.05 | 82 | 23277 | 15135 | 90589953 |
| Overdose | 171.19 | 17.05 | 207 | 23152 | 157502 | 90447586 |
| Hypothermia | 163.51 | 17.05 | 80 | 23279 | 15495 | 90589593 |
| Bradycardia | 149.15 | 17.05 | 143 | 23216 | 83704 | 90521384 |
| Fall | 143.21 | 17.05 | 355 | 23004 | 481455 | 90123633 |
| Intentional product misuse | 141.13 | 17.05 | 143 | 23216 | 89461 | 90515627 |
| Electrocardiogram QT prolonged | 137.31 | 17.05 | 128 | 23231 | 72328 | 90532760 |
| Hepatocellular injury | 136.72 | 17.05 | 88 | 23271 | 28870 | 90576218 |
| Respiratory acidosis | 126.94 | 17.05 | 55 | 23304 | 8064 | 90597024 |
| Substance use disorder | 125.58 | 17.05 | 38 | 23321 | 1982 | 90603106 |
| Hypokalaemia | 122.92 | 17.05 | 160 | 23199 | 130956 | 90474132 |
| Prescription form tampering | 122.48 | 17.05 | 30 | 23329 | 697 | 90604391 |
| Parkinsonism | 103.73 | 17.05 | 57 | 23302 | 14008 | 90591080 |
| Pneumonia aspiration | 100.93 | 17.05 | 84 | 23275 | 40856 | 90564232 |
| Depressed level of consciousness | 99.98 | 17.05 | 108 | 23251 | 72676 | 90532412 |
| Joint swelling | 99.75 | 17.05 | 8 | 23351 | 503292 | 90101796 |
| Bradyphrenia | 94.85 | 17.05 | 44 | 23315 | 7568 | 90597520 |
| Confusional state | 93.62 | 17.05 | 264 | 23095 | 385941 | 90219147 |
| Acute kidney injury | 91.76 | 17.05 | 233 | 23126 | 320154 | 90284934 |
| Toxic epidermal necrolysis | 91.30 | 17.05 | 72 | 23287 | 32456 | 90572632 |
| Abdominal discomfort | 90.77 | 17.05 | 9 | 23350 | 477319 | 90127769 |
| Pain | 88.97 | 17.05 | 76 | 23283 | 996265 | 89608823 |
| Intentional self-injury | 86.81 | 17.05 | 67 | 23292 | 29267 | 90575821 |
| Asphyxia | 82.16 | 17.05 | 39 | 23320 | 7064 | 90598024 |
| Infusion related reaction | 81.52 | 17.05 | 7 | 23352 | 416773 | 90188315 |
| Systemic lupus erythematosus | 80.14 | 17.05 | 3 | 23356 | 361893 | 90243195 |
| Toxic skin eruption | 79.58 | 17.05 | 50 | 23309 | 15724 | 90589364 |
| Extrapyramidal disorder | 78.07 | 17.05 | 50 | 23309 | 16253 | 90588835 |
| Arthropathy | 77.93 | 17.05 | 4 | 23355 | 366238 | 90238850 |
| Metabolic acidosis | 77.12 | 17.05 | 83 | 23276 | 55593 | 90549495 |
| Suicidal ideation | 75.27 | 17.05 | 94 | 23265 | 73761 | 90531327 |
| Hyperthermia | 73.78 | 17.05 | 41 | 23318 | 10294 | 90594794 |
| Peripheral swelling | 73.02 | 17.05 | 10 | 23349 | 413096 | 90191992 |
| Drug ineffective | 70.95 | 17.05 | 158 | 23201 | 1384140 | 89220948 |
| Hypoglycaemia | 69.75 | 17.05 | 88 | 23271 | 69760 | 90535328 |
| Drug hypersensitivity | 69.57 | 17.05 | 17 | 23342 | 463592 | 90141496 |
| Psychomotor hyperactivity | 68.14 | 17.05 | 42 | 23317 | 12771 | 90592317 |
| Persecutory delusion | 67.96 | 17.05 | 27 | 23332 | 3181 | 90601907 |
| Respiratory depression | 67.81 | 17.05 | 45 | 23314 | 15530 | 90589558 |
| Alopecia | 67.17 | 17.05 | 22 | 23337 | 495049 | 90110039 |
| Nasopharyngitis | 67.09 | 17.05 | 12 | 23347 | 407092 | 90197996 |
| Rhabdomyolysis | 66.79 | 17.05 | 74 | 23285 | 51182 | 90553906 |
| Agitation | 66.15 | 17.05 | 84 | 23275 | 67014 | 90538074 |
| Treatment failure | 65.67 | 17.05 | 3 | 23356 | 303925 | 90301163 |
| Accidental death | 64.35 | 17.05 | 23 | 23336 | 2025 | 90603063 |
| Cor pulmonale acute | 63.06 | 17.05 | 16 | 23343 | 431 | 90604657 |
| Tremor | 62.21 | 17.05 | 128 | 23231 | 153045 | 90452043 |
| Swelling | 61.64 | 17.05 | 16 | 23343 | 419042 | 90186046 |
| Rheumatoid arthritis | 61.26 | 17.05 | 10 | 23349 | 362604 | 90242484 |
| Drug intolerance | 60.51 | 17.05 | 20 | 23339 | 447571 | 90157517 |
| Arrhythmia | 60.20 | 17.05 | 64 | 23295 | 42268 | 90562820 |
| Therapeutic product effect decreased | 59.13 | 17.05 | 3 | 23356 | 277568 | 90327520 |
| Hepatitis acute | 58.69 | 17.05 | 36 | 23323 | 10851 | 90594237 |
| Contraindicated product administered | 58.37 | 17.05 | 7 | 23352 | 320132 | 90284956 |
| Vertigo | 57.44 | 17.05 | 80 | 23279 | 69731 | 90535357 |
| Inappropriate antidiuretic hormone secretion | 56.51 | 17.05 | 44 | 23315 | 19461 | 90585627 |
| Sinusitis | 54.63 | 17.05 | 11 | 23348 | 343077 | 90262011 |
| Disorientation | 54.59 | 17.05 | 62 | 23297 | 44052 | 90561036 |
| Disturbance in attention | 54.58 | 17.05 | 64 | 23295 | 47045 | 90558043 |
| Bezoar | 54.42 | 17.05 | 22 | 23337 | 2712 | 90602376 |
| Pericarditis | 54.30 | 17.05 | 4 | 23355 | 270147 | 90334941 |
| Bradykinesia | 54.20 | 17.05 | 29 | 23330 | 6759 | 90598329 |
| Coma scale abnormal | 53.42 | 17.05 | 27 | 23332 | 5599 | 90599489 |
| Psychomotor skills impaired | 53.37 | 17.05 | 22 | 23337 | 2850 | 90602238 |
| Loss of consciousness | 53.22 | 17.05 | 114 | 23245 | 140124 | 90464964 |
| Withdrawal syndrome | 52.99 | 17.05 | 45 | 23314 | 22479 | 90582609 |
| Dermatitis exfoliative | 50.91 | 17.05 | 26 | 23333 | 5510 | 90599578 |
| Hepatic enzyme increased | 50.74 | 17.05 | 15 | 23344 | 360721 | 90244367 |
| Rash | 50.18 | 17.05 | 80 | 23279 | 796020 | 89809068 |
| Wrong rate | 49.51 | 17.05 | 11 | 23348 | 164 | 90604924 |
| Livedo reticularis | 49.43 | 17.05 | 22 | 23337 | 3437 | 90601651 |
| Wheezing | 49.38 | 17.05 | 3 | 23356 | 238077 | 90367011 |
| Arthralgia | 49.28 | 17.05 | 78 | 23281 | 778444 | 89826644 |
| Labelled drug-drug interaction issue | 47.82 | 17.05 | 19 | 23340 | 2239 | 90602849 |
| Wound | 47.64 | 17.05 | 10 | 23349 | 302970 | 90302118 |
| Product dose omission issue | 47.17 | 17.05 | 9 | 23350 | 291678 | 90313410 |
| Vasoplegia syndrome | 47.07 | 17.05 | 20 | 23339 | 2794 | 90602294 |
| Lower respiratory tract infection | 46.89 | 17.05 | 5 | 23354 | 250654 | 90354434 |
| Hypersensitivity | 45.13 | 17.05 | 31 | 23328 | 454646 | 90150442 |
| Serotonin syndrome | 44.77 | 17.05 | 52 | 23307 | 37835 | 90567253 |
| Hypercapnic coma | 44.65 | 17.05 | 11 | 23348 | 262 | 90604826 |
| Electrocardiogram QRS complex prolonged | 44.01 | 17.05 | 26 | 23333 | 7322 | 90597766 |
| Salivary hypersecretion | 43.81 | 17.05 | 28 | 23331 | 9064 | 90596024 |
| Cholestasis | 43.19 | 17.05 | 50 | 23309 | 36249 | 90568839 |
| Cholinergic syndrome | 42.86 | 17.05 | 13 | 23346 | 683 | 90604405 |
| Sinus tachycardia | 42.12 | 17.05 | 44 | 23315 | 28469 | 90576619 |
| Autoimmune haemolytic anaemia | 41.96 | 17.05 | 23 | 23336 | 5622 | 90599466 |
| Lactic acidosis | 41.76 | 17.05 | 58 | 23301 | 50405 | 90554683 |
| Meningioma | 41.43 | 17.05 | 22 | 23337 | 5049 | 90600039 |
| Postmortem blood drug level abnormal | 40.43 | 17.05 | 10 | 23349 | 242 | 90604846 |
| Cardiogenic shock | 40.22 | 17.05 | 40 | 23319 | 24428 | 90580660 |
| Contusion | 40.09 | 17.05 | 8 | 23351 | 251208 | 90353880 |
| Agranulocytosis | 39.63 | 17.05 | 47 | 23312 | 34955 | 90570133 |
| Irritable bowel syndrome | 39.15 | 17.05 | 4 | 23355 | 207444 | 90397644 |
| Leukocytosis | 39.09 | 17.05 | 44 | 23315 | 30946 | 90574142 |
| Hepatitis toxic | 38.69 | 17.05 | 19 | 23340 | 3706 | 90601382 |
| Sinoatrial block | 38.17 | 17.05 | 13 | 23346 | 992 | 90604096 |
| Thymus disorder | 37.76 | 17.05 | 10 | 23349 | 320 | 90604768 |
| Blood cholesterol increased | 36.80 | 17.05 | 5 | 23354 | 208007 | 90397081 |
| Impaired healing | 36.26 | 17.05 | 8 | 23351 | 234191 | 90370897 |
| Myoglobin blood increased | 36.18 | 17.05 | 14 | 23345 | 1538 | 90603550 |
| Sinus bradycardia | 36.10 | 17.05 | 32 | 23327 | 16920 | 90588168 |
| Drug level increased | 36.02 | 17.05 | 40 | 23319 | 27722 | 90577366 |
| Hepatic cytolysis | 35.81 | 17.05 | 42 | 23317 | 30874 | 90574214 |
| Housebound | 35.66 | 17.05 | 9 | 23350 | 237 | 90604851 |
| Infection | 35.50 | 17.05 | 25 | 23334 | 362069 | 90243019 |
| Muscle injury | 34.41 | 17.05 | 3 | 23356 | 176651 | 90428437 |
| Mobility decreased | 34.21 | 17.05 | 11 | 23348 | 250723 | 90354365 |
| Ventricular dyskinesia | 34.19 | 17.05 | 8 | 23351 | 152 | 90604936 |
| Cross sensitivity reaction | 34.00 | 17.05 | 16 | 23343 | 2841 | 90602247 |
| Hyperthyroidism | 33.99 | 17.05 | 32 | 23327 | 18278 | 90586810 |
| Musculoskeletal stiffness | 33.95 | 17.05 | 17 | 23342 | 296515 | 90308573 |
| Psychiatric decompensation | 33.13 | 17.05 | 14 | 23345 | 1929 | 90603159 |
| Pyramidal tract syndrome | 32.55 | 17.05 | 10 | 23349 | 549 | 90604539 |
| Alcohol abuse | 32.52 | 17.05 | 14 | 23345 | 2019 | 90603069 |
| Bronchospasm | 32.47 | 17.05 | 33 | 23326 | 20676 | 90584412 |
| Drug reaction with eosinophilia and systemic symptoms | 32.22 | 17.05 | 47 | 23312 | 42711 | 90562377 |
| Prevertebral soft tissue swelling of cervical space | 31.92 | 17.05 | 6 | 23353 | 36 | 90605052 |
| Osteoarthritis | 31.72 | 17.05 | 6 | 23353 | 195724 | 90409364 |
| Pneumonia | 31.54 | 17.05 | 74 | 23285 | 637985 | 89967103 |
| Multiple organ dysfunction syndrome | 31.19 | 17.05 | 60 | 23299 | 68276 | 90536812 |
| Discomfort | 31.00 | 17.05 | 16 | 23343 | 274319 | 90330769 |
| Hypercapnia | 30.79 | 17.05 | 20 | 23339 | 6657 | 90598431 |
| Incorrect product administration duration | 30.68 | 17.05 | 31 | 23328 | 19291 | 90585797 |
| Analgesic drug level increased | 30.65 | 17.05 | 15 | 23344 | 2904 | 90602184 |
| Traumatic intracranial haemorrhage | 30.57 | 17.05 | 10 | 23349 | 673 | 90604415 |
| Cerebral haematoma | 30.57 | 17.05 | 17 | 23342 | 4272 | 90600816 |
| Pain in extremity | 30.52 | 17.05 | 43 | 23316 | 450486 | 90154602 |
| Migraine | 30.50 | 17.05 | 6 | 23353 | 190386 | 90414702 |
| Gastrointestinal disorder | 30.48 | 17.05 | 14 | 23345 | 256673 | 90348415 |
| Muscle rigidity | 30.45 | 17.05 | 27 | 23332 | 14282 | 90590806 |
| Cholecystitis | 30.14 | 17.05 | 29 | 23330 | 17011 | 90588077 |
| Tachycardia | 29.86 | 17.05 | 99 | 23260 | 157574 | 90447514 |
| Substance abuse | 29.46 | 17.05 | 18 | 23341 | 5388 | 90599700 |
| Fatigue | 29.41 | 17.05 | 176 | 23183 | 1153847 | 89451241 |
| Nystagmus | 29.34 | 17.05 | 20 | 23339 | 7207 | 90597881 |
| Bundle branch block right | 29.31 | 17.05 | 18 | 23341 | 5435 | 90599653 |
| Ill-defined disorder | 29.26 | 17.05 | 6 | 23353 | 184885 | 90420203 |
| Asthma | 29.07 | 17.05 | 13 | 23346 | 242147 | 90362941 |
| Apallic syndrome | 29.07 | 17.05 | 10 | 23349 | 786 | 90604302 |
| Product use issue | 28.30 | 17.05 | 26 | 23333 | 329893 | 90275195 |
| Fear of weight gain | 28.28 | 17.05 | 5 | 23354 | 20 | 90605068 |
| Fibromyalgia | 28.22 | 17.05 | 9 | 23350 | 206260 | 90398828 |
| Stomatitis | 28.21 | 17.05 | 18 | 23341 | 274680 | 90330408 |
| Hyperchloraemia | 28.00 | 17.05 | 10 | 23349 | 878 | 90604210 |
| Apathy | 27.92 | 17.05 | 23 | 23336 | 11017 | 90594071 |
| Hallucination | 26.61 | 17.05 | 55 | 23304 | 65904 | 90539184 |
| Patella fracture | 26.50 | 17.05 | 13 | 23346 | 2530 | 90602558 |
| Hypoosmolar state | 26.37 | 17.05 | 7 | 23352 | 226 | 90604862 |
| Victim of chemical submission | 25.89 | 17.05 | 9 | 23350 | 730 | 90604358 |
| Circulatory collapse | 25.84 | 17.05 | 32 | 23327 | 24872 | 90580216 |
| Dependence | 25.76 | 17.05 | 12 | 23347 | 2083 | 90603005 |
| Chorea | 25.68 | 17.05 | 12 | 23347 | 2098 | 90602990 |
| Major depression | 25.57 | 17.05 | 21 | 23338 | 10014 | 90595074 |
| Growth disorder | 25.57 | 17.05 | 5 | 23354 | 38 | 90605050 |
| Headache | 25.57 | 17.05 | 125 | 23234 | 862621 | 89742467 |
| Eosinophilia | 25.43 | 17.05 | 34 | 23325 | 28499 | 90576589 |
| Cutaneous T-cell lymphoma | 25.40 | 17.05 | 11 | 23348 | 1609 | 90603479 |
| Dyspepsia | 24.80 | 17.05 | 10 | 23349 | 198150 | 90406938 |
| Haemolytic anaemia | 24.75 | 17.05 | 22 | 23337 | 11675 | 90593413 |
| Electrocardiogram QRS complex shortened | 24.38 | 17.05 | 8 | 23351 | 544 | 90604544 |
| Acute pulmonary oedema | 24.31 | 17.05 | 20 | 23339 | 9560 | 90595528 |
| Antipsychotic drug level increased | 24.29 | 17.05 | 14 | 23345 | 3765 | 90601323 |
| Stress cardiomyopathy | 24.14 | 17.05 | 23 | 23336 | 13332 | 90591756 |
| Therapeutic product effect incomplete | 23.92 | 17.05 | 10 | 23349 | 193886 | 90411202 |
| Rash maculo-papular | 23.88 | 17.05 | 40 | 23319 | 40893 | 90564195 |
| Drug screen false positive | 23.75 | 17.05 | 9 | 23350 | 934 | 90604154 |
| Psychomotor retardation | 23.70 | 17.05 | 15 | 23344 | 4774 | 90600314 |
| Hyperkalaemia | 23.70 | 17.05 | 52 | 23307 | 64912 | 90540176 |
| Bursitis | 23.68 | 17.05 | 3 | 23356 | 131651 | 90473437 |
| Drug detoxification | 23.47 | 17.05 | 7 | 23352 | 347 | 90604741 |
| Eczema eyelids | 23.40 | 17.05 | 7 | 23352 | 351 | 90604737 |
| Injury | 23.06 | 17.05 | 11 | 23348 | 197338 | 90407750 |
| Nasal mucosal erosion | 23.00 | 17.05 | 5 | 23354 | 67 | 90605021 |
| Night sweats | 23.00 | 17.05 | 3 | 23356 | 128763 | 90476325 |
| Haemodynamic instability | 22.72 | 17.05 | 21 | 23338 | 11718 | 90593370 |
| Renal tubular necrosis | 22.47 | 17.05 | 23 | 23336 | 14532 | 90590556 |
| Cardiorenal syndrome | 22.31 | 17.05 | 9 | 23350 | 1103 | 90603985 |
| Orthostatic hypotension | 21.94 | 17.05 | 39 | 23320 | 41788 | 90563300 |
| Maternal exposure during pregnancy | 21.85 | 17.05 | 37 | 23322 | 360026 | 90245062 |
| Cyanosis | 21.81 | 17.05 | 26 | 23333 | 19429 | 90585659 |
| Avoidant personality disorder | 21.78 | 17.05 | 5 | 23354 | 87 | 90605001 |
| Arthritis | 21.67 | 17.05 | 8 | 23351 | 167307 | 90437781 |
| Torsade de pointes | 21.66 | 17.05 | 23 | 23336 | 15159 | 90589929 |
| Malignant catatonia | 21.61 | 17.05 | 6 | 23353 | 230 | 90604858 |
| Generalised tonic-clonic seizure | 21.56 | 17.05 | 35 | 23324 | 34868 | 90570220 |
| Tonic convulsion | 21.51 | 17.05 | 10 | 23349 | 1728 | 90603360 |
| Cell death | 21.48 | 17.05 | 12 | 23347 | 3043 | 90602045 |
| Intentional product use issue | 21.21 | 17.05 | 15 | 23344 | 216877 | 90388211 |
| Mucosal erosion | 20.94 | 17.05 | 10 | 23349 | 1835 | 90603253 |
| Inflammation | 20.79 | 17.05 | 10 | 23349 | 178582 | 90426506 |
| Hyperleukocytosis | 20.67 | 17.05 | 8 | 23351 | 879 | 90604209 |
| Aortic valve disease | 20.65 | 17.05 | 9 | 23350 | 1337 | 90603751 |
| Haemoglobin decreased | 20.55 | 17.05 | 8 | 23351 | 161948 | 90443140 |
| Platelet count decreased | 20.55 | 17.05 | 5 | 23354 | 136964 | 90468124 |
| Loss of personal independence in daily activities | 20.36 | 17.05 | 5 | 23354 | 136100 | 90468988 |
| Executive dysfunction | 20.31 | 17.05 | 6 | 23353 | 288 | 90604800 |
| Stevens-Johnson syndrome | 20.28 | 17.05 | 31 | 23328 | 29345 | 90575743 |
| White blood cell count decreased | 20.01 | 17.05 | 9 | 23350 | 167100 | 90437988 |
| Generalised anxiety disorder | 19.89 | 17.05 | 11 | 23348 | 2736 | 90602352 |
| Gastrooesophageal reflux disease | 19.85 | 17.05 | 9 | 23350 | 166328 | 90438760 |
| Violence-related symptom | 19.72 | 17.05 | 7 | 23352 | 604 | 90604484 |
| Hepatic necrosis | 19.69 | 17.05 | 15 | 23344 | 6423 | 90598665 |
| Cardiac output decreased | 19.59 | 17.05 | 8 | 23351 | 1012 | 90604076 |
| Urinary retention | 19.55 | 17.05 | 35 | 23324 | 37709 | 90567379 |
| Off label use | 19.52 | 17.05 | 186 | 23173 | 1102066 | 89503022 |
| Electric shock sensation | 19.32 | 17.05 | 9 | 23350 | 1561 | 90603527 |
| Hypoaesthesia | 19.32 | 17.05 | 32 | 23327 | 314178 | 90290910 |
| Occupational dermatitis | 19.30 | 17.05 | 4 | 23355 | 42 | 90605046 |
| Chronic fatigue syndrome | 19.28 | 17.05 | 9 | 23350 | 1570 | 90603518 |
| Dermatitis exfoliative generalised | 19.27 | 17.05 | 14 | 23345 | 5579 | 90599509 |
| Liver injury | 19.18 | 17.05 | 10 | 23349 | 170557 | 90434531 |
| Apraxia | 19.01 | 17.05 | 10 | 23349 | 2252 | 90602836 |
| Paraesthesia | 18.89 | 17.05 | 22 | 23337 | 250304 | 90354784 |
| Myoclonus | 18.88 | 17.05 | 24 | 23335 | 19144 | 90585944 |
| Upper respiratory tract infection | 18.64 | 17.05 | 5 | 23354 | 128313 | 90476775 |
| Oliguria | 18.64 | 17.05 | 18 | 23341 | 10606 | 90594482 |
| Shock haemorrhagic | 18.27 | 17.05 | 19 | 23340 | 12226 | 90592862 |
| Craniocerebral injury | 18.02 | 17.05 | 11 | 23348 | 3287 | 90601801 |
| Mental disability | 17.90 | 17.05 | 5 | 23354 | 196 | 90604892 |
| Electrolyte imbalance | 17.74 | 17.05 | 26 | 23333 | 23719 | 90581369 |
| Toxic encephalopathy | 17.69 | 17.05 | 16 | 23343 | 8683 | 90596405 |
| Oropharyngeal pain | 17.69 | 17.05 | 4 | 23355 | 115183 | 90489905 |
| Status epilepticus | 17.60 | 17.05 | 23 | 23336 | 18851 | 90586237 |
| Rash scarlatiniform | 17.59 | 17.05 | 5 | 23354 | 209 | 90604879 |
| Hypotonia | 17.54 | 17.05 | 18 | 23341 | 11408 | 90593680 |
| Neurological decompensation | 17.41 | 17.05 | 11 | 23348 | 3490 | 90601598 |
| Hallucination, auditory | 17.34 | 17.05 | 21 | 23338 | 15954 | 90589134 |
| Speech disorder | 17.21 | 17.05 | 37 | 23322 | 45548 | 90559540 |
| Drug dependence, antepartum | 17.14 | 17.05 | 4 | 23355 | 75 | 90605013 |
| Labelled drug-disease interaction issue | 17.14 | 17.05 | 4 | 23355 | 75 | 90605013 |
| Pulmonary embolism | 17.14 | 17.05 | 73 | 23286 | 130747 | 90474341 |
| Liver disorder | 17.11 | 17.05 | 5 | 23354 | 121264 | 90483824 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Drug use disorder | 649.23 | 20.18 | 208 | 14045 | 10125 | 42596957 |
| Coma | 600.57 | 20.18 | 312 | 13941 | 53242 | 42553840 |
| Drug abuse | 579.59 | 20.18 | 386 | 13867 | 104385 | 42502697 |
| Substance use disorder | 378.67 | 20.18 | 118 | 14135 | 5227 | 42601855 |
| Poisoning deliberate | 322.67 | 20.18 | 123 | 14130 | 10011 | 42597071 |
| Toxicity to various agents | 287.50 | 20.18 | 367 | 13886 | 228769 | 42378313 |
| Somnolence | 265.90 | 20.18 | 279 | 13974 | 140826 | 42466256 |
| Mydriasis | 200.97 | 20.18 | 84 | 14169 | 8686 | 42598396 |
| Drug dependence | 199.24 | 20.18 | 123 | 14130 | 28971 | 42578111 |
| Miosis | 190.47 | 20.18 | 92 | 14161 | 13354 | 42593728 |
| Poisoning | 179.76 | 20.18 | 91 | 14162 | 14608 | 42592474 |
| Altered state of consciousness | 161.47 | 20.18 | 108 | 14145 | 29151 | 42577931 |
| Substance abuse | 154.15 | 20.18 | 70 | 14183 | 8835 | 42598247 |
| Intentional product misuse | 150.74 | 20.18 | 141 | 14112 | 61759 | 42545323 |
| Intentional overdose | 148.52 | 20.18 | 129 | 14124 | 51327 | 42555755 |
| Pneumonia aspiration | 125.60 | 20.18 | 116 | 14137 | 49962 | 42557120 |
| Asphyxia | 121.01 | 20.18 | 58 | 14195 | 8268 | 42598814 |
| Sopor | 119.77 | 20.18 | 67 | 14186 | 13135 | 42593947 |
| Hypothermia | 96.14 | 20.18 | 57 | 14196 | 12458 | 42594624 |
| Depressed level of consciousness | 92.03 | 20.18 | 96 | 14157 | 47874 | 42559208 |
| Bradypnoea | 87.13 | 20.18 | 38 | 14215 | 4355 | 42602727 |
| Agitation | 86.44 | 20.18 | 107 | 14146 | 64207 | 42542875 |
| Suicide attempt | 84.41 | 20.18 | 90 | 14163 | 46010 | 42561072 |
| Aggression | 82.24 | 20.18 | 87 | 14166 | 44076 | 42563006 |
| Drug ineffective | 74.91 | 20.18 | 61 | 14192 | 630136 | 41976946 |
| Visceral congestion | 71.77 | 20.18 | 22 | 14231 | 919 | 42606163 |
| Hyperthermia | 65.93 | 20.18 | 45 | 14208 | 12529 | 42594553 |
| Mucosal dryness | 62.98 | 20.18 | 23 | 14230 | 1655 | 42605427 |
| Withdrawal syndrome | 55.03 | 20.18 | 43 | 14210 | 14732 | 42592350 |
| Overdose | 54.21 | 20.18 | 113 | 14140 | 105151 | 42501931 |
| Prescription form tampering | 53.96 | 20.18 | 16 | 14237 | 596 | 42606486 |
| Behaviour disorder | 48.68 | 20.18 | 30 | 14223 | 7024 | 42600058 |
| Pneumonia | 48.60 | 20.18 | 42 | 14211 | 422107 | 42184975 |
| Oral discharge | 47.44 | 20.18 | 11 | 14242 | 152 | 42606930 |
| Screaming | 45.76 | 20.18 | 19 | 14234 | 1928 | 42605154 |
| Left atrial dilatation | 45.11 | 20.18 | 20 | 14233 | 2382 | 42604700 |
| Suicidal ideation | 44.71 | 20.18 | 67 | 14186 | 48094 | 42558988 |
| Haematocrit increased | 43.84 | 20.18 | 20 | 14233 | 2547 | 42604535 |
| Confusional state | 42.63 | 20.18 | 138 | 14115 | 167459 | 42439623 |
| Cluster headache | 42.27 | 20.18 | 13 | 14240 | 549 | 42606533 |
| Bradycardia | 41.94 | 20.18 | 90 | 14163 | 85394 | 42521688 |
| Intestinal atony | 40.48 | 20.18 | 8 | 14245 | 48 | 42607034 |
| Product dose omission issue | 40.17 | 20.18 | 3 | 14250 | 154362 | 42452720 |
| Housebound | 38.38 | 20.18 | 10 | 14243 | 229 | 42606853 |
| Bradyphrenia | 37.89 | 20.18 | 23 | 14230 | 5239 | 42601843 |
| Lactic acidosis | 37.84 | 20.18 | 60 | 14193 | 45201 | 42561881 |
| Vertigo | 36.57 | 20.18 | 51 | 14202 | 34296 | 42572786 |
| Gas poisoning | 36.35 | 20.18 | 8 | 14245 | 86 | 42606996 |
| Disturbance in attention | 35.83 | 20.18 | 47 | 14206 | 29819 | 42577263 |
| Nervous system disorder | 35.82 | 20.18 | 36 | 14217 | 17159 | 42589923 |
| Vascular stenosis | 35.60 | 20.18 | 9 | 14244 | 182 | 42606900 |
| Hypovolaemia | 35.53 | 20.18 | 30 | 14223 | 11455 | 42595627 |
| Laryngeal dyspnoea | 34.81 | 20.18 | 8 | 14245 | 106 | 42606976 |
| Bradykinesia | 34.69 | 20.18 | 22 | 14231 | 5414 | 42601668 |
| Alcohol abuse | 32.55 | 20.18 | 19 | 14234 | 4030 | 42603052 |
| Rhabdomyolysis | 32.51 | 20.18 | 77 | 14176 | 77942 | 42529140 |
| Brain oedema | 31.86 | 20.18 | 33 | 14220 | 16294 | 42590788 |
| Amyotrophy | 31.40 | 20.18 | 10 | 14243 | 474 | 42606608 |
| Hepatocellular injury | 31.13 | 20.18 | 39 | 14214 | 23639 | 42583443 |
| Haemoglobin increased | 30.58 | 20.18 | 20 | 14233 | 5186 | 42601896 |
| Loss of consciousness | 30.03 | 20.18 | 83 | 14170 | 92271 | 42514811 |
| Gastrointestinal necrosis | 29.61 | 20.18 | 18 | 14235 | 4110 | 42602972 |
| Arthralgia | 29.43 | 20.18 | 16 | 14237 | 205222 | 42401860 |
| Sepsis | 29.38 | 20.18 | 15 | 14238 | 199319 | 42407763 |
| Drug detoxification | 29.17 | 20.18 | 9 | 14244 | 384 | 42606698 |
| Incorrect product administration duration | 28.37 | 20.18 | 20 | 14233 | 5860 | 42601222 |
| Brief psychotic disorder with marked stressors | 27.85 | 20.18 | 8 | 14245 | 266 | 42606816 |
| Lichenoid keratosis | 27.76 | 20.18 | 17 | 14236 | 3933 | 42603149 |
| Pulmonary congestion | 27.51 | 20.18 | 30 | 14223 | 15700 | 42591382 |
| Acute kidney injury | 26.81 | 20.18 | 212 | 14041 | 367125 | 42239957 |
| Phlebotomy | 26.43 | 20.18 | 6 | 14247 | 75 | 42607007 |
| Fatigue | 26.09 | 20.18 | 68 | 14185 | 435573 | 42171509 |
| Hypotension | 26.02 | 20.18 | 161 | 14092 | 257470 | 42349612 |
| Sinus bradycardia | 25.41 | 20.18 | 28 | 14225 | 14825 | 42592257 |
| Parotid gland haemorrhage | 25.30 | 20.18 | 5 | 14248 | 30 | 42607052 |
| Victim of homicide | 25.22 | 20.18 | 7 | 14246 | 205 | 42606877 |
| Traumatic haemothorax | 24.59 | 20.18 | 8 | 14245 | 406 | 42606676 |
| Cerebrovascular stenosis | 24.09 | 20.18 | 6 | 14247 | 114 | 42606968 |
| White blood cell count decreased | 24.07 | 20.18 | 4 | 14249 | 110392 | 42496690 |
| Psychomotor skills impaired | 23.49 | 20.18 | 17 | 14236 | 5187 | 42601895 |
| Platelet count decreased | 22.64 | 20.18 | 9 | 14244 | 138572 | 42468510 |
| Victim of crime | 22.44 | 20.18 | 8 | 14245 | 537 | 42606545 |
| Ischaemic hepatitis | 22.36 | 20.18 | 12 | 14241 | 2165 | 42604917 |
| Cerebral haematoma | 22.35 | 20.18 | 17 | 14236 | 5593 | 42601489 |
| Wrong drug | 22.08 | 20.18 | 6 | 14247 | 162 | 42606920 |
| Restlessness | 22.03 | 20.18 | 37 | 14216 | 29212 | 42577870 |
| Abnormal behaviour | 22.01 | 20.18 | 35 | 14218 | 26416 | 42580666 |
| Presyncope | 21.99 | 20.18 | 32 | 14221 | 22355 | 42584727 |
| Anal haemorrhage | 21.83 | 20.18 | 13 | 14240 | 2860 | 42604222 |
| Systolic hypertension | 21.76 | 20.18 | 7 | 14246 | 343 | 42606739 |
| Hepatic cytolysis | 21.63 | 20.18 | 35 | 14218 | 26809 | 42580273 |
| Wrong patient received product | 21.62 | 20.18 | 14 | 14239 | 3569 | 42603513 |
| Cognitive disorder | 21.57 | 20.18 | 40 | 14213 | 34132 | 42572950 |
| Subdural haematoma | 21.19 | 20.18 | 32 | 14221 | 23106 | 42583976 |
| Psychomotor hyperactivity | 21.11 | 20.18 | 22 | 14231 | 10936 | 42596146 |
| Drug diversion | 21.08 | 20.18 | 9 | 14244 | 978 | 42606104 |
| Dyspnoea | 20.87 | 20.18 | 77 | 14176 | 442544 | 42164538 |
| Anxiety disorder due to a general medical condition | 20.85 | 20.18 | 4 | 14249 | 20 | 42607062 |
| Pancreatitis acute | 20.83 | 20.18 | 39 | 14214 | 33525 | 42573557 |
| Faecaloma | 20.68 | 20.18 | 17 | 14236 | 6253 | 42600829 |
| Motor dysfunction | 20.64 | 20.18 | 19 | 14234 | 8127 | 42598955 |
| Haemodynamic instability | 20.33 | 20.18 | 23 | 14230 | 12534 | 42594548 |
| Toxic skin eruption | 20.30 | 20.18 | 24 | 14229 | 13706 | 42593376 |
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Coma | 1537.64 | 15.76 | 756 | 35513 | 117113 | 110435917 |
| Drug abuse | 1365.28 | 15.76 | 801 | 35468 | 176610 | 110376420 |
| Drug use disorder | 1217.22 | 15.76 | 382 | 35887 | 17692 | 110535338 |
| Poisoning deliberate | 1011.96 | 15.76 | 365 | 35904 | 25966 | 110527064 |
| Toxicity to various agents | 719.55 | 15.76 | 834 | 35435 | 479721 | 110073309 |
| Somnolence | 607.53 | 15.76 | 609 | 35660 | 296840 | 110256190 |
| Sopor | 596.40 | 15.76 | 274 | 35995 | 36272 | 110516758 |
| Substance use disorder | 498.52 | 15.76 | 156 | 36113 | 7134 | 110545896 |
| Intentional overdose | 497.76 | 15.76 | 384 | 35885 | 132117 | 110420913 |
| Miosis | 384.36 | 15.76 | 173 | 36096 | 21810 | 110531220 |
| Mydriasis | 383.06 | 15.76 | 173 | 36096 | 21984 | 110531046 |
| Suicide attempt | 382.37 | 15.76 | 297 | 35972 | 103097 | 110449933 |
| Altered state of consciousness | 354.29 | 15.76 | 226 | 36043 | 57400 | 110495630 |
| Poisoning | 326.58 | 15.76 | 169 | 36100 | 28936 | 110524094 |
| Drug dependence | 280.01 | 15.76 | 185 | 36084 | 49835 | 110503195 |
| Intentional product misuse | 268.52 | 15.76 | 271 | 35998 | 132633 | 110420397 |
| Bradypnoea | 259.23 | 15.76 | 100 | 36169 | 8549 | 110544481 |
| Hypothermia | 253.46 | 15.76 | 138 | 36131 | 26164 | 110526866 |
| Pneumonia aspiration | 222.19 | 15.76 | 196 | 36073 | 81037 | 110471993 |
| Hypotension | 205.28 | 15.76 | 498 | 35771 | 523351 | 110029679 |
| Overdose | 203.31 | 15.76 | 312 | 35957 | 233482 | 110319548 |
| Depressed level of consciousness | 196.35 | 15.76 | 212 | 36057 | 112066 | 110440964 |
| Substance abuse | 180.17 | 15.76 | 86 | 36183 | 12377 | 110540653 |
| Drug interaction | 177.49 | 15.76 | 458 | 35811 | 499725 | 110053305 |
| Bradycardia | 169.38 | 15.76 | 231 | 36038 | 155286 | 110397744 |
| Asphyxia | 157.86 | 15.76 | 82 | 36187 | 14133 | 110538897 |
| Agitation | 154.60 | 15.76 | 188 | 36081 | 112863 | 110440167 |
| Hepatocellular injury | 148.13 | 15.76 | 127 | 36142 | 50515 | 110502515 |
| Fall | 144.27 | 15.76 | 480 | 35789 | 603002 | 109950028 |
| Respiratory acidosis | 134.45 | 15.76 | 73 | 36196 | 13753 | 110539277 |
| Confusional state | 134.23 | 15.76 | 397 | 35872 | 468283 | 110084747 |
| Hyperthermia | 129.59 | 15.76 | 83 | 36186 | 21189 | 110531841 |
| Bradyphrenia | 125.51 | 15.76 | 66 | 36203 | 11662 | 110541368 |
| Suicidal ideation | 121.62 | 15.76 | 152 | 36117 | 93785 | 110459245 |
| Drug ineffective | 118.12 | 15.76 | 199 | 36070 | 1520341 | 109032689 |
| Hyponatraemia | 115.57 | 15.76 | 234 | 36035 | 217419 | 110335611 |
| Joint swelling | 111.46 | 15.76 | 9 | 36260 | 442836 | 110110194 |
| Electrocardiogram QT prolonged | 106.90 | 15.76 | 154 | 36115 | 108806 | 110444224 |
| Intentional self-injury | 101.66 | 15.76 | 90 | 36179 | 37339 | 110515691 |
| Acute kidney injury | 101.00 | 15.76 | 444 | 35825 | 634986 | 109918044 |
| Parkinsonism | 100.36 | 15.76 | 72 | 36197 | 22115 | 110530915 |
| Aggression | 100.30 | 15.76 | 110 | 36159 | 59100 | 110493930 |
| Abdominal discomfort | 96.40 | 15.76 | 9 | 36260 | 393849 | 110159181 |
| Vertigo | 92.94 | 15.76 | 128 | 36141 | 86742 | 110466288 |
| Peripheral swelling | 91.89 | 15.76 | 12 | 36257 | 404022 | 110149008 |
| Bradykinesia | 88.65 | 15.76 | 51 | 36218 | 10737 | 110542293 |
| Rhabdomyolysis | 87.19 | 15.76 | 148 | 36121 | 120253 | 110432777 |
| Withdrawal syndrome | 86.31 | 15.76 | 76 | 36193 | 31304 | 110521726 |
| Pain | 85.55 | 15.76 | 113 | 36156 | 954842 | 109598188 |
| Extrapyramidal disorder | 83.60 | 15.76 | 72 | 36197 | 28795 | 110524235 |
| Infusion related reaction | 82.76 | 15.76 | 13 | 36256 | 381149 | 110171881 |
| Psychomotor hyperactivity | 80.88 | 15.76 | 61 | 36208 | 20216 | 110532814 |
| Arthralgia | 79.72 | 15.76 | 83 | 36186 | 779549 | 109773481 |
| Hypokalaemia | 79.39 | 15.76 | 181 | 36088 | 182267 | 110370763 |
| Disturbance in attention | 78.13 | 15.76 | 99 | 36170 | 61896 | 110491134 |
| Arthropathy | 77.77 | 15.76 | 4 | 36265 | 287518 | 110265512 |
| Drug hypersensitivity | 76.02 | 15.76 | 27 | 36242 | 454063 | 110098967 |
| Loss of consciousness | 75.92 | 15.76 | 186 | 36083 | 196120 | 110356910 |
| Prescription form tampering | 75.43 | 15.76 | 20 | 36249 | 501 | 110552529 |
| Pneumonia | 73.24 | 15.76 | 109 | 36160 | 876605 | 109676425 |
| Housebound | 72.91 | 15.76 | 19 | 36250 | 444 | 110552586 |
| Toxic skin eruption | 72.41 | 15.76 | 65 | 36204 | 27450 | 110525580 |
| Lactic acidosis | 71.08 | 15.76 | 117 | 36152 | 92694 | 110460336 |
| Psychomotor skills impaired | 70.67 | 15.76 | 38 | 36231 | 7020 | 110546010 |
| Systemic lupus erythematosus | 70.53 | 15.76 | 3 | 36266 | 254335 | 110298695 |
| Rheumatoid arthritis | 70.31 | 15.76 | 8 | 36261 | 299605 | 110253425 |
| Product dose omission issue | 69.78 | 15.76 | 11 | 36258 | 321771 | 110231259 |
| Inappropriate antidiuretic hormone secretion | 66.39 | 15.76 | 68 | 36201 | 33783 | 110519247 |
| Sinusitis | 64.66 | 15.76 | 10 | 36259 | 296678 | 110256352 |
| Visceral congestion | 64.46 | 15.76 | 22 | 36247 | 1323 | 110551707 |
| Therapeutic product effect decreased | 64.22 | 15.76 | 4 | 36265 | 244312 | 110308718 |
| Alopecia | 63.99 | 15.76 | 20 | 36249 | 364733 | 110188297 |
| Swelling | 63.86 | 15.76 | 18 | 36251 | 351023 | 110202007 |
| Drug intolerance | 61.78 | 15.76 | 28 | 36241 | 406484 | 110146546 |
| Tremor | 60.31 | 15.76 | 174 | 36095 | 202058 | 110350972 |
| Disorientation | 59.46 | 15.76 | 93 | 36176 | 70578 | 110482452 |
| Hypoglycaemia | 59.40 | 15.76 | 123 | 36146 | 115981 | 110437049 |
| Alcohol abuse | 59.26 | 15.76 | 30 | 36239 | 4899 | 110548131 |
| Sinus bradycardia | 59.23 | 15.76 | 60 | 36209 | 29423 | 110523607 |
| Respiratory depression | 58.66 | 15.76 | 62 | 36207 | 31939 | 110521091 |
| Metabolic acidosis | 58.64 | 15.76 | 112 | 36157 | 99632 | 110453398 |
| Lower respiratory tract infection | 58.28 | 15.76 | 6 | 36263 | 243100 | 110309930 |
| Mucosal dryness | 57.33 | 15.76 | 28 | 36241 | 4235 | 110548795 |
| Incorrect product administration duration | 55.08 | 15.76 | 49 | 36220 | 20449 | 110532581 |
| Cor pulmonale acute | 55.04 | 15.76 | 17 | 36252 | 743 | 110552287 |
| Arrhythmia | 55.02 | 15.76 | 89 | 36180 | 69486 | 110483544 |
| Wheezing | 54.71 | 15.76 | 9 | 36260 | 255221 | 110297809 |
| Pericarditis | 53.60 | 15.76 | 5 | 36264 | 219109 | 110333921 |
| Hepatic cytolysis | 52.78 | 15.76 | 77 | 36192 | 54976 | 110498054 |
| Rash | 52.58 | 15.76 | 120 | 36149 | 820844 | 109732186 |
| Persecutory delusion | 52.38 | 15.76 | 30 | 36239 | 6261 | 110546769 |
| Psoriatic arthropathy | 52.38 | 15.76 | 3 | 36266 | 196758 | 110356272 |
| Nasopharyngitis | 51.39 | 15.76 | 33 | 36236 | 394328 | 110158702 |
| Toxic epidermal necrolysis | 51.02 | 15.76 | 77 | 36192 | 56650 | 110496380 |
| Pain in extremity | 50.69 | 15.76 | 51 | 36218 | 487067 | 110065963 |
| Hepatic enzyme increased | 50.49 | 15.76 | 21 | 36248 | 320871 | 110232159 |
| Accidental death | 50.24 | 15.76 | 27 | 36242 | 4982 | 110548048 |
| Behaviour disorder | 49.91 | 15.76 | 34 | 36235 | 9613 | 110543417 |
| Treatment failure | 48.97 | 15.76 | 15 | 36254 | 277219 | 110275811 |
| Hepatitis acute | 48.72 | 15.76 | 44 | 36225 | 18722 | 110534308 |
| Fatigue | 48.38 | 15.76 | 220 | 36049 | 1215738 | 109337292 |
| Cerebral haematoma | 47.60 | 15.76 | 33 | 36236 | 9599 | 110543431 |
| Hypersensitivity | 47.16 | 15.76 | 38 | 36231 | 403960 | 110149070 |
| Infection | 46.25 | 15.76 | 31 | 36238 | 362169 | 110190861 |
| Asthma | 45.20 | 15.76 | 13 | 36256 | 250278 | 110302752 |
| Livedo reticularis | 45.16 | 15.76 | 26 | 36243 | 5480 | 110547550 |
| White blood cell count decreased | 45.11 | 15.76 | 10 | 36259 | 229380 | 110323650 |
| Amyotrophy | 43.82 | 15.76 | 14 | 36255 | 684 | 110552346 |
| Mobility decreased | 43.48 | 15.76 | 12 | 36257 | 237410 | 110315620 |
| Blood cholesterol increased | 43.17 | 15.76 | 5 | 36264 | 184780 | 110368250 |
| Wound | 42.66 | 15.76 | 12 | 36257 | 234425 | 110318605 |
| Tachycardia | 42.63 | 15.76 | 167 | 36102 | 226478 | 110326552 |
| Irritable bowel syndrome | 42.23 | 15.76 | 3 | 36266 | 164212 | 110388818 |
| Platelet count decreased | 41.55 | 15.76 | 12 | 36257 | 230431 | 110322599 |
| Oral discharge | 41.51 | 15.76 | 11 | 36258 | 275 | 110552755 |
| Pulmonary congestion | 41.48 | 15.76 | 51 | 36218 | 30915 | 110522115 |
| Haemodynamic instability | 41.34 | 15.76 | 44 | 36225 | 22844 | 110530186 |
| Wrong rate | 41.22 | 15.76 | 10 | 36259 | 173 | 110552857 |
| Gastrointestinal disorder | 41.12 | 15.76 | 14 | 36255 | 241938 | 110311092 |
| Bezoar | 41.07 | 15.76 | 22 | 36247 | 4032 | 110548998 |
| Drug reaction with eosinophilia and systemic symptoms | 40.85 | 15.76 | 86 | 36183 | 82009 | 110471021 |
| Dermatitis exfoliative | 40.59 | 15.76 | 32 | 36237 | 11315 | 110541715 |
| Folliculitis | 40.54 | 15.76 | 4 | 36265 | 167649 | 110385381 |
| Ill-defined disorder | 39.95 | 15.76 | 3 | 36266 | 156850 | 110396180 |
| Impaired healing | 39.86 | 15.76 | 8 | 36261 | 196709 | 110356321 |
| Gastrooesophageal reflux disease | 39.35 | 15.76 | 6 | 36263 | 179970 | 110373060 |
| Hypercapnic coma | 39.33 | 15.76 | 12 | 36257 | 503 | 110552527 |
| Electrocardiogram QRS complex prolonged | 38.76 | 15.76 | 33 | 36236 | 12988 | 110540042 |
| Musculoskeletal stiffness | 38.42 | 15.76 | 22 | 36247 | 279800 | 110273230 |
| Left atrial dilatation | 37.99 | 15.76 | 20 | 36249 | 3540 | 110549490 |
| Dyspnoea | 37.85 | 15.76 | 211 | 36058 | 1106661 | 109446369 |
| Cholestasis | 37.37 | 15.76 | 72 | 36197 | 64446 | 110488584 |
| Contusion | 37.14 | 15.76 | 15 | 36254 | 233346 | 110319684 |
| Sinoatrial block | 37.10 | 15.76 | 15 | 36254 | 1450 | 110551580 |
| Haemoglobin decreased | 36.43 | 15.76 | 18 | 36251 | 248709 | 110304321 |
| Cluster headache | 36.32 | 15.76 | 14 | 36255 | 1193 | 110551837 |
| Contraindicated product administered | 36.31 | 15.76 | 18 | 36251 | 248249 | 110304781 |
| Gas poisoning | 36.25 | 15.76 | 8 | 36261 | 89 | 110552941 |
| Salivary hypersecretion | 35.99 | 15.76 | 36 | 36233 | 17385 | 110535645 |
| Osteoarthritis | 35.83 | 15.76 | 8 | 36261 | 182615 | 110370415 |
| Hepatitis toxic | 35.80 | 15.76 | 23 | 36246 | 5898 | 110547132 |
| Tonic convulsion | 34.89 | 15.76 | 18 | 36251 | 3056 | 110549974 |
| Therapeutic product effect incomplete | 34.63 | 15.76 | 15 | 36254 | 223790 | 110329240 |
| Fibromyalgia | 34.52 | 15.76 | 7 | 36262 | 170902 | 110382128 |
| Meningioma | 34.24 | 15.76 | 22 | 36247 | 5643 | 110547387 |
| Headache | 34.21 | 15.76 | 161 | 36108 | 882216 | 109670814 |
| Coma scale abnormal | 33.87 | 15.76 | 27 | 36242 | 9699 | 110543331 |
| Cardiac failure congestive | 33.09 | 15.76 | 5 | 36264 | 150995 | 110402035 |
| Serotonin syndrome | 33.02 | 15.76 | 65 | 36204 | 59088 | 110493942 |
| Night sweats | 32.91 | 15.76 | 3 | 36266 | 133980 | 110419050 |
| Nervous system disorder | 32.80 | 15.76 | 46 | 36223 | 31675 | 110521355 |
| Apraxia | 32.51 | 15.76 | 18 | 36251 | 3522 | 110549508 |
| Orthostatic hypotension | 32.49 | 15.76 | 69 | 36200 | 66180 | 110486850 |
| Screaming | 32.11 | 15.76 | 20 | 36249 | 4861 | 110548169 |
| Brain oedema | 32.01 | 15.76 | 45 | 36224 | 31053 | 110521977 |
| Product use issue | 31.98 | 15.76 | 33 | 36236 | 311662 | 110241368 |
| Haematocrit increased | 31.82 | 15.76 | 20 | 36249 | 4939 | 110548091 |
| Off label use | 31.80 | 15.76 | 327 | 35942 | 1499858 | 109053172 |
| Cognitive disorder | 31.78 | 15.76 | 81 | 36188 | 87430 | 110465600 |
| Arthritis | 31.58 | 15.76 | 8 | 36261 | 167578 | 110385452 |
| Victim of crime | 31.08 | 15.76 | 13 | 36256 | 1370 | 110551660 |
| Abnormal behaviour | 30.94 | 15.76 | 50 | 36219 | 38989 | 110514041 |
| Migraine | 30.83 | 15.76 | 9 | 36260 | 171643 | 110381387 |
| Traumatic haemothorax | 30.74 | 15.76 | 11 | 36258 | 761 | 110552269 |
| Prevertebral soft tissue swelling of cervical space | 30.47 | 15.76 | 6 | 36263 | 36 | 110552994 |
| Restlessness | 30.42 | 15.76 | 61 | 36208 | 56198 | 110496832 |
| Vasoplegia syndrome | 30.13 | 15.76 | 20 | 36249 | 5419 | 110547611 |
| Labelled drug-drug interaction issue | 30.04 | 15.76 | 18 | 36251 | 4083 | 110548947 |
| Nystagmus | 29.77 | 15.76 | 27 | 36242 | 11550 | 110541480 |
| Thymus disorder | 29.71 | 15.76 | 10 | 36259 | 576 | 110552454 |
| Drug detoxification | 29.68 | 15.76 | 10 | 36259 | 578 | 110552452 |
| Victim of chemical submission | 29.35 | 15.76 | 11 | 36258 | 868 | 110552162 |
| Bursitis | 29.17 | 15.76 | 4 | 36265 | 129914 | 110423116 |
| Intestinal atony | 29.08 | 15.76 | 8 | 36261 | 231 | 110552799 |
| Postmortem blood drug level abnormal | 28.85 | 15.76 | 10 | 36259 | 630 | 110552400 |
| Oropharyngeal pain | 28.47 | 15.76 | 5 | 36264 | 135271 | 110417759 |
| Hypoaesthesia | 28.21 | 15.76 | 37 | 36232 | 314186 | 110238844 |
| Cholinergic syndrome | 28.20 | 15.76 | 12 | 36257 | 1320 | 110551710 |
| Dependence | 28.18 | 15.76 | 15 | 36254 | 2714 | 110550316 |
| Drug diversion | 27.79 | 15.76 | 12 | 36257 | 1368 | 110551662 |
| Fear of weight gain | 27.28 | 15.76 | 5 | 36264 | 19 | 110553011 |
| Status epilepticus | 27.18 | 15.76 | 42 | 36227 | 31529 | 110521501 |
| Patella fracture | 26.95 | 15.76 | 14 | 36255 | 2412 | 110550618 |
| Hospitalisation | 26.46 | 15.76 | 7 | 36262 | 142486 | 110410544 |
| Pancreatitis acute | 26.41 | 15.76 | 60 | 36209 | 60214 | 110492816 |
| Purpura | 26.16 | 15.76 | 36 | 36233 | 24352 | 110528678 |
| Cardiogenic shock | 26.15 | 15.76 | 58 | 36211 | 57280 | 110495750 |
| Pyramidal tract syndrome | 26.11 | 15.76 | 10 | 36259 | 837 | 110552193 |
| Laryngeal dyspnoea | 25.94 | 15.76 | 8 | 36261 | 348 | 110552682 |
| Brief psychotic disorder with marked stressors | 25.85 | 15.76 | 8 | 36261 | 352 | 110552678 |
| Phlebotomy | 25.79 | 15.76 | 6 | 36263 | 86 | 110552944 |
| Toxic encephalopathy | 25.29 | 15.76 | 28 | 36241 | 15186 | 110537844 |
| Adverse event | 25.27 | 15.76 | 3 | 36266 | 108806 | 110444224 |
| Parotid gland haemorrhage | 25.26 | 15.76 | 5 | 36264 | 31 | 110552999 |
| Nausea | 25.05 | 15.76 | 272 | 35997 | 1235418 | 109317612 |
| Maternal exposure during pregnancy | 25.01 | 15.76 | 28 | 36241 | 254855 | 110298175 |
| Drug level increased | 24.92 | 15.76 | 51 | 36218 | 47668 | 110505362 |
| Dyspepsia | 24.83 | 15.76 | 16 | 36253 | 190949 | 110362081 |
| Anal haemorrhage | 24.55 | 15.76 | 17 | 36252 | 4935 | 110548095 |
| Hypotonia | 24.51 | 15.76 | 28 | 36241 | 15717 | 110537313 |
| Injection site pain | 24.40 | 15.76 | 14 | 36255 | 177908 | 110375122 |
| Wrong patient received product | 24.25 | 15.76 | 19 | 36250 | 6655 | 110546375 |
| Subdural haematoma | 24.01 | 15.76 | 43 | 36226 | 36411 | 110516619 |
| Substance dependence | 23.94 | 15.76 | 9 | 36260 | 716 | 110552314 |
| Ventricular dyskinesia | 23.94 | 15.76 | 8 | 36261 | 451 | 110552579 |
| Hyperthyroidism | 23.90 | 15.76 | 38 | 36231 | 29223 | 110523807 |
| Victim of homicide | 23.86 | 15.76 | 7 | 36262 | 256 | 110552774 |
| Urinary retention | 23.76 | 15.76 | 63 | 36206 | 69620 | 110483410 |
| Wrong patient | 23.68 | 15.76 | 11 | 36258 | 1488 | 110551542 |
| Apallic syndrome | 23.53 | 15.76 | 10 | 36259 | 1096 | 110551934 |
| Vascular stenosis | 23.32 | 15.76 | 9 | 36260 | 769 | 110552261 |
| Agranulocytosis | 23.29 | 15.76 | 58 | 36211 | 61702 | 110491328 |
| Loss of personal independence in daily activities | 23.29 | 15.76 | 10 | 36259 | 150010 | 110403020 |
| Rash maculo-papular | 23.21 | 15.76 | 65 | 36204 | 74157 | 110478873 |
| Analgesic drug level increased | 23.05 | 15.76 | 15 | 36254 | 3931 | 110549099 |
| Acute pulmonary oedema | 22.78 | 15.76 | 28 | 36241 | 16968 | 110536062 |
| Occupational exposure to product | 22.67 | 15.76 | 9 | 36260 | 830 | 110552200 |
| Delusion | 22.44 | 15.76 | 33 | 36236 | 23722 | 110529308 |
| Sepsis | 22.42 | 15.76 | 46 | 36223 | 327300 | 110225730 |
| Gastrointestinal necrosis | 22.20 | 15.76 | 18 | 36251 | 6622 | 110546408 |
| Autoimmune haemolytic anaemia | 22.13 | 15.76 | 22 | 36247 | 10545 | 110542485 |
| Cyanosis | 22.09 | 15.76 | 37 | 36232 | 29704 | 110523326 |
| Cerebrovascular stenosis | 21.99 | 15.76 | 6 | 36263 | 168 | 110552862 |
| Hyperchloraemia | 21.93 | 15.76 | 10 | 36259 | 1296 | 110551734 |
| Nasal mucosal erosion | 21.80 | 15.76 | 5 | 36264 | 67 | 110552963 |
| Presyncope | 21.79 | 15.76 | 49 | 36220 | 48838 | 110504192 |
| Hypovolaemia | 21.77 | 15.76 | 31 | 36238 | 21643 | 110531387 |
| Discomfort | 21.71 | 15.76 | 23 | 36246 | 214684 | 110338346 |
| Blood creatinine increased | 21.57 | 15.76 | 17 | 36252 | 182872 | 110370158 |
| Phlebitis | 21.56 | 15.76 | 21 | 36248 | 9820 | 110543210 |
| Cough | 21.09 | 15.76 | 79 | 36190 | 461562 | 110091468 |
| Haemoglobin increased | 20.95 | 15.76 | 20 | 36249 | 9127 | 110543903 |
| Hallucination | 20.92 | 15.76 | 77 | 36192 | 101355 | 110451675 |
| Traumatic intracranial haemorrhage | 20.77 | 15.76 | 10 | 36259 | 1466 | 110551564 |
| Prescription drug used without a prescription | 20.74 | 15.76 | 16 | 36253 | 5480 | 110547550 |
| Hypoosmolar state | 20.65 | 15.76 | 7 | 36262 | 412 | 110552618 |
| Cross sensitivity reaction | 20.56 | 15.76 | 16 | 36253 | 5551 | 110547479 |
| Eczema eyelids | 20.52 | 15.76 | 7 | 36262 | 420 | 110552610 |
| Anxiety disorder due to a general medical condition | 20.46 | 15.76 | 4 | 36265 | 23 | 110553007 |
| Sciatica | 20.38 | 15.76 | 3 | 36266 | 92396 | 110460634 |
| Sinus tachycardia | 20.28 | 15.76 | 45 | 36224 | 44448 | 110508582 |
| Generalised tonic-clonic seizure | 20.25 | 15.76 | 51 | 36218 | 54629 | 110498401 |
| Stomatitis | 20.23 | 15.76 | 36 | 36233 | 270206 | 110282824 |
| Major depression | 20.22 | 15.76 | 21 | 36248 | 10600 | 110542430 |
| Avoidant personality disorder | 20.02 | 15.76 | 5 | 36264 | 98 | 110552932 |
| COVID-19 treatment | 19.97 | 15.76 | 7 | 36262 | 456 | 110552574 |
| Hallucination, auditory | 19.82 | 15.76 | 33 | 36236 | 26364 | 110526666 |
| Myoglobin blood increased | 19.75 | 15.76 | 14 | 36255 | 4218 | 110548812 |
| Psychomotor retardation | 19.70 | 15.76 | 18 | 36251 | 7774 | 110545256 |
| Neurological decompensation | 19.58 | 15.76 | 17 | 36252 | 6866 | 110546164 |
| Electrocardiogram QRS complex shortened | 19.41 | 15.76 | 8 | 36261 | 812 | 110552218 |
| Hypercapnia | 19.35 | 15.76 | 21 | 36248 | 11138 | 110541892 |
| Liver function test increased | 19.24 | 15.76 | 3 | 36266 | 88545 | 110464485 |
| Growth disorder | 19.18 | 15.76 | 5 | 36264 | 117 | 110552913 |
| Hypertensive crisis | 19.02 | 15.76 | 31 | 36238 | 24341 | 110528689 |
| Apathy | 18.99 | 15.76 | 25 | 36244 | 16214 | 110536816 |
| Neutrophil count decreased | 18.87 | 15.76 | 8 | 36261 | 120933 | 110432097 |
| Lichenoid keratosis | 18.82 | 15.76 | 16 | 36253 | 6286 | 110546744 |
| Injection site erythema | 18.72 | 15.76 | 4 | 36265 | 94172 | 110458858 |
| Back pain | 18.61 | 15.76 | 61 | 36208 | 370935 | 110182095 |
| Drug screen false positive | 18.43 | 15.76 | 9 | 36260 | 1360 | 110551670 |
| Eosinophilia | 18.37 | 15.76 | 51 | 36218 | 57885 | 110495145 |
| Gait inability | 18.31 | 15.76 | 11 | 36258 | 136365 | 110416665 |
| Haemolytic anaemia | 18.25 | 15.76 | 28 | 36241 | 20892 | 110532138 |
| C-reactive protein increased | 18.21 | 15.76 | 27 | 36242 | 217892 | 110335138 |
| Chorea | 18.17 | 15.76 | 12 | 36257 | 3223 | 110549807 |
| Systolic hypertension | 18.17 | 15.76 | 8 | 36261 | 956 | 110552074 |
| Chronic fatigue syndrome | 18.07 | 15.76 | 9 | 36260 | 1420 | 110551610 |
| Acute respiratory distress syndrome | 18.04 | 15.76 | 48 | 36221 | 53150 | 110499880 |
| Psychiatric decompensation | 17.96 | 15.76 | 15 | 36254 | 5750 | 110547280 |
| Conjunctival hyperaemia | 17.81 | 15.76 | 15 | 36254 | 5816 | 110547214 |
| Bundle branch block right | 17.70 | 15.76 | 21 | 36248 | 12270 | 110540760 |
| Condition aggravated | 17.69 | 15.76 | 155 | 36114 | 734681 | 109818349 |
| Leukocytosis | 17.68 | 15.76 | 48 | 36221 | 53780 | 110499250 |
| Craniocerebral injury | 17.58 | 15.76 | 15 | 36254 | 5919 | 110547111 |
| Rash scarlatiniform | 17.56 | 15.76 | 6 | 36263 | 362 | 110552668 |
| Urinary tract infection | 17.52 | 15.76 | 52 | 36217 | 326230 | 110226800 |
| Generalised anxiety disorder | 17.31 | 15.76 | 11 | 36258 | 2768 | 110550262 |
| Anaphylactic reaction | 17.14 | 15.76 | 8 | 36261 | 114292 | 110438738 |
| Upper respiratory tract infection | 17.07 | 15.76 | 11 | 36258 | 131317 | 110421713 |
| Dry skin | 16.99 | 15.76 | 7 | 36262 | 107646 | 110445384 |
| Ischaemic stroke | 16.89 | 15.76 | 40 | 36229 | 41223 | 110511807 |
| Shock | 16.82 | 15.76 | 47 | 36222 | 53541 | 110499489 |
| Executive dysfunction | 16.71 | 15.76 | 6 | 36263 | 419 | 110552611 |
| Muscle rigidity | 16.67 | 15.76 | 29 | 36240 | 24002 | 110529028 |
| Learning disorder | 16.67 | 15.76 | 7 | 36262 | 745 | 110552285 |
| Dysarthria | 16.63 | 15.76 | 63 | 36206 | 84058 | 110468972 |
| Bronchospasm | 16.60 | 15.76 | 33 | 36236 | 30206 | 110522824 |
| Respiratory distress | 16.55 | 15.76 | 55 | 36214 | 68819 | 110484211 |
| Psoriasis | 16.52 | 15.76 | 13 | 36256 | 139980 | 110413050 |
| Hyperkalaemia | 16.49 | 15.76 | 88 | 36181 | 135708 | 110417322 |
| Stress cardiomyopathy | 16.46 | 15.76 | 23 | 36246 | 15783 | 110537247 |
| Stress | 16.39 | 15.76 | 7 | 36262 | 105341 | 110447689 |
| Cholecystitis | 16.37 | 15.76 | 30 | 36239 | 25852 | 110527178 |
| Wrong drug | 16.37 | 15.76 | 6 | 36263 | 445 | 110552585 |
| Sudden death | 16.35 | 15.76 | 29 | 36240 | 24366 | 110528664 |
| Abdominal distension | 16.35 | 15.76 | 20 | 36249 | 175083 | 110377947 |
| Mental disability | 15.92 | 15.76 | 5 | 36264 | 231 | 110552799 |
| Cellulitis | 15.78 | 15.76 | 11 | 36258 | 126005 | 110427025 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | N05BA08 | NERVOUS SYSTEM PSYCHOLEPTICS ANXIOLYTICS Benzodiazepine derivatives |
| MeSH PA | D002492 | Central Nervous System Depressants |
| MeSH PA | D011619 | Psychotropic Drugs |
| MeSH PA | D014151 | Anti-Anxiety Agents |
| MeSH PA | D018377 | Neurotransmitter Agents |
| MeSH PA | D018682 | GABA Agents |
| MeSH PA | D018757 | GABA Modulators |
| CHEBI has role | CHEBI:35469 | antidepressant |
| CHEBI has role | CHEBI:35474 | anxiolytic drug |
| CHEBI has role | CHEBI:35476 | antipsychotic agent |
Related Drugs by ATC class:
N05BA Benzodiazepine derivatives 23 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 11.29 | acidic |
| pKa2 | 3.26 | Basic |
| pKa3 | 2.58 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| GABA-A receptor alpha-1/beta-2/gamma-2 | Ion channel | WOMBAT-PK |
External reference:
| ID | Source |
|---|---|
| N0000166922 | NUI |
| D01245 | KEGG_DRUG |
| 1749 | RXNORM |
| C0006213 | UMLSCUI |
| CHEBI:31302 | CHEBI |
| CHEMBL277062 | ChEMBL_ID |
| DB01558 | DRUGBANK_ID |
| D001960 | MESH_DESCRIPTOR_UI |
| 2441 | PUBCHEM_CID |
| 2692 | INN_ID |
| X015L14V0O | UNII |
| 11834 | MMSL |
| 387571009 | SNOMEDCT_US |
| 96234002 | SNOMEDCT_US |
| 003512 | NDDF |
Pharmaceutical products:
None