alprazolam Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
diazepam derivatives 136 28981-97-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • xanax
  • alprazolam
  • alprozolam
  • alzolam
A triazolobenzodiazepine compound with antianxiety and sedative-hypnotic actions, that is efficacious in the treatment of PANIC DISORDERS, with or without AGORAPHOBIA, and in generalized ANXIETY DISORDERS. (From AMA Drug Evaluations Annual, 1994, p238)
  • Molecular weight: 308.77
  • Formula: C17H13ClN4
  • CLOGP: 2.55
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 0
  • TPSA: 43.07
  • ALOGS: -3.98
  • ROTB: 1

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
1 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.07 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 20 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.46 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 88 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.80 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 0.74 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.29 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 12 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Oct. 16, 1981 FDA PHARMACIA AND UPJOHN

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug abuse 4962.81 9.60 3229 203260 60179 46419394
Completed suicide 3168.18 9.60 3550 202939 142370 46337203
Sopor 1604.58 9.60 1033 205456 18795 46460778
Toxicity to various agents 1453.38 9.60 3012 203477 208754 46270819
Respiratory arrest 1126.36 9.60 1039 205450 32777 46446796
Poisoning 993.40 9.60 672 205817 13322 46466251
Suicide attempt 792.24 9.60 1092 205397 53944 46425629
Cardio-respiratory arrest 724.45 9.60 1094 205395 58775 46420798
Intentional overdose 719.07 9.60 1139 205350 63805 46415768
Cardiac arrest 635.79 9.60 1301 205188 89098 46390475
Poisoning deliberate 516.14 9.60 361 206128 7565 46472008
Drug dependence 499.26 9.60 524 205965 19377 46460196
Anxiety 493.98 9.60 1846 204643 180111 46299462
Rheumatoid arthritis 491.46 9.60 224 206265 239991 46239582
Overdose 470.64 9.60 1244 205245 100735 46378838
Coma 459.72 9.60 881 205608 57468 46422105
Intentional self-injury 448.55 9.60 544 205945 23622 46455951
Intentional product misuse 315.43 9.60 665 205824 46463 46433110
Somnolence 295.17 9.60 1422 205067 155099 46324474
Treatment failure 232.64 9.60 62 206427 93025 46386548
Drug ineffective 229.81 9.60 1910 204579 675928 45803645
Contraindicated product administered 228.86 9.60 39 206450 79908 46399665
Bradyphrenia 210.30 9.60 193 206296 6037 46473536
Drug intolerance 208.03 9.60 206 206283 146843 46332730
Depression 205.61 9.60 1372 205117 168732 46310841
Synovitis 203.53 9.60 18 206471 61057 46418516
Off label use 193.18 9.60 944 205545 378897 46100676
Suicidal ideation 191.65 9.60 617 205872 55765 46423808
Pemphigus 184.74 9.60 3 206486 45271 46434302
Drug withdrawal syndrome 176.92 9.60 381 206108 27003 46452570
Panic attack 175.99 9.60 319 206170 19923 46459650
Infusion related reaction 169.92 9.60 120 206369 101088 46378485
Joint swelling 166.35 9.60 300 206189 165773 46313800
Exposure via ingestion 156.86 9.60 127 206362 3340 46476233
Mydriasis 139.21 9.60 201 206288 10352 46469221
Substance abuse 138.53 9.60 128 206361 4039 46475534
Withdrawal syndrome 135.61 9.60 268 206221 17866 46461707
Prescription form tampering 125.61 9.60 61 206428 619 46478954
Lower respiratory tract infection 121.06 9.60 46 206443 55043 46424530
Maternal exposure during pregnancy 117.92 9.60 169 206320 102380 46377193
Agitation 113.41 9.60 516 205973 54899 46424674
Systemic lupus erythematosus 111.07 9.60 76 206413 65104 46414469
Hand deformity 110.43 9.60 12 206477 34562 46445011
Victim of chemical submission 109.75 9.60 43 206446 244 46479329
Insomnia 103.85 9.60 1151 205338 163773 46315800
Nasopharyngitis 103.10 9.60 343 206146 153655 46325918
Tremor 96.59 9.60 856 205633 114783 46364790
Arthralgia 92.45 9.60 1100 205389 363503 46116070
Confusional state 91.74 9.60 1096 205393 158796 46320777
Death 91.63 9.60 2033 204456 333515 46146058
Loss of consciousness 91.31 9.60 803 205686 107435 46372138
Infection 89.10 9.60 298 206191 133294 46346279
Arthropathy 88.37 9.60 149 206340 84551 46395022
Drug hypersensitivity 87.08 9.60 676 205813 243149 46236424
Drug use disorder 79.48 9.60 78 206411 2657 46476916
Therapeutic product effect incomplete 77.44 9.60 142 206347 78011 46401562
Febrile neutropenia 77.04 9.60 192 206297 94435 46385138
Disturbance in attention 77.00 9.60 310 206179 31250 46448323
Pneumonia 76.72 9.60 1187 205302 375133 46104440
Alopecia 75.32 9.60 416 206073 161998 46317575
Peripheral swelling 74.33 9.60 403 206086 157668 46321905
Cough 72.87 9.60 659 205830 229590 46249983
C-reactive protein abnormal 71.58 9.60 6 206483 21264 46458309
Accidental overdose 71.25 9.60 223 206266 19843 46459730
C-reactive protein increased 70.90 9.60 93 206396 58497 46421076
Product use issue 69.53 9.60 202 206287 94442 46385131
Anti-cyclic citrullinated peptide antibody positive 68.48 9.60 4 206485 19141 46460432
Drug screen positive 67.98 9.60 85 206404 3806 46475767
Crying 67.88 9.60 227 206262 20914 46458659
Pyrexia 66.79 9.60 1113 205376 347689 46131884
Nervousness 65.76 9.60 275 206214 28200 46451373
Rash 64.59 9.60 1149 205340 355363 46124210
Drug abuser 63.60 9.60 75 206414 3158 46476415
Hypokinesia 62.48 9.60 148 206341 11174 46468399
Hepatocellular injury 61.95 9.60 277 206212 29245 46450328
Depressed level of consciousness 60.55 9.60 389 206100 47180 46432393
Memory impairment 60.22 9.60 564 205925 76773 46402800
Glossodynia 59.47 9.60 65 206424 44308 46435265
Swelling 57.66 9.60 319 206170 124192 46355381
Feeling abnormal 57.34 9.60 823 205666 124237 46355336
Disorientation 55.98 9.60 316 206173 36602 46442971
Alcohol abuse 55.90 9.60 58 206431 2114 46477459
Hypersensitivity 55.85 9.60 412 206077 149909 46329664
Miosis 55.44 9.60 103 206386 6554 46473019
Pericarditis 54.22 9.60 19 206470 23908 46455665
Renal impairment 53.70 9.60 160 206329 74212 46405361
Sepsis 53.34 9.60 367 206122 135647 46343926
Bradykinesia 52.98 9.60 76 206413 3890 46475683
General physical health deterioration 52.84 9.60 298 206191 115471 46364102
Wrong patient received product 51.34 9.60 50 206439 1687 46477886
Drug resistance 50.73 9.60 8 206481 17360 46462213
Therapeutic product effect decreased 50.54 9.60 191 206298 82410 46397163
Malignant neoplasm progression 49.57 9.60 136 206353 64790 46414783
Exposure during pregnancy 48.60 9.60 280 206209 107932 46371641
Amnesia 48.49 9.60 333 206156 41298 46438275
Abnormal behaviour 48.33 9.60 203 206286 20855 46458718
Neutropenia 48.30 9.60 403 206086 142801 46336772
Homicide 45.62 9.60 27 206462 419 46479154
Fall 45.53 9.60 1833 204656 327264 46152309
Pancytopenia 43.84 9.60 210 206279 84848 46394725
Irritability 42.72 9.60 246 206243 28700 46450873
Euphoric mood 41.89 9.60 71 206418 4201 46475372
Dependence 41.69 9.60 47 206442 1884 46477689
Musculoskeletal stiffness 41.66 9.60 258 206231 97735 46381838
Bradypnoea 40.25 9.60 58 206431 2981 46476592
Product use in unapproved indication 39.77 9.60 235 206254 90038 46389535
Abdominal discomfort 39.75 9.60 452 206037 150713 46328860
Aggression 39.45 9.60 202 206287 22542 46457031
Neutrophil count decreased 38.63 9.60 84 206405 43342 46436231
Thinking abnormal 38.53 9.60 113 206376 9701 46469872
Cytomegalovirus infection 38.46 9.60 16 206473 18128 46461445
Hepatic enzyme increased 37.59 9.60 210 206279 81577 46397996
Premature delivery 37.23 9.60 26 206463 22043 46457530
Mental disorder 36.03 9.60 195 206294 22230 46457343
Chemical submission 36.00 9.60 19 206470 233 46479340
Mucosal inflammation 35.83 9.60 74 206415 38902 46440671
Immobilisation prolonged 35.54 9.60 13 206476 59 46479514
Altered state of consciousness 35.49 9.60 200 206289 23148 46456425
Cardiac failure 35.28 9.60 208 206281 79740 46399833
Neutropenic sepsis 35.27 9.60 6 206483 12318 46467255
Blood creatinine increased 35.21 9.60 196 206293 76207 46403366
Femur fracture 35.07 9.60 69 206420 36928 46442645
Abnormal dreams 34.45 9.60 112 206377 10167 46469406
Mania 34.41 9.60 116 206373 10730 46468843
Asthma 34.41 9.60 250 206239 91292 46388281
Respiratory depression 34.13 9.60 121 206368 11479 46468094
Compartment syndrome 33.86 9.60 43 206446 1956 46477617
Suspected suicide 33.78 9.60 68 206421 4593 46474980
Mobility decreased 33.36 9.60 146 206343 60448 46419125
Sedation 33.35 9.60 194 206295 22716 46456857
Product complaint 32.88 9.60 123 206366 11978 46467595
Injury 32.73 9.60 318 206171 43709 46435864
Anger 32.65 9.60 121 206368 11731 46467842
Psychomotor skills impaired 32.35 9.60 44 206445 2142 46477431
Sinusitis 31.81 9.60 394 206095 129374 46350199
Psychomotor hyperactivity 31.55 9.60 104 206385 9509 46470064
Housebound 31.35 9.60 17 206472 221 46479352
Knee arthroplasty 31.34 9.60 35 206454 23630 46455943
Medication error 30.68 9.60 238 206251 30673 46448900
Anaphylactic reaction 30.45 9.60 126 206363 52986 46426587
Renal papillary necrosis 30.25 9.60 17 206472 238 46479335
Adjustment disorder with mixed anxiety and depressed mood 29.80 9.60 12 206477 74 46479499
Hallucination, auditory 29.79 9.60 110 206379 10646 46468927
Herpes zoster 29.73 9.60 177 206312 67695 46411878
Substance use disorder 29.37 9.60 10 206479 35 46479538
Bipolar I disorder 28.99 9.60 35 206454 1511 46478062
Liver function test increased 28.89 9.60 35 206454 22791 46456782
Obsessive-compulsive disorder 28.36 9.60 51 206438 3164 46476409
Device expulsion 28.21 9.60 49 206440 27493 46452080
Platelet count decreased 27.91 9.60 295 206194 99729 46379844
Skin ulcer 27.87 9.60 64 206425 32394 46447179
Blood pressure diastolic decreased 27.84 9.60 14 206475 14197 46465376
Impaired driving ability 27.53 9.60 59 206430 4165 46475408
Diarrhoea 27.41 9.60 2118 204371 557484 45922089
Vertigo 27.30 9.60 351 206138 51697 46427876
Abortion spontaneous 27.29 9.60 100 206389 43546 46436027
Accidental death 27.25 9.60 37 206452 1798 46477775
Extrapyramidal disorder 26.94 9.60 110 206379 11158 46468415
Anaemia 26.74 9.60 895 205594 254884 46224689
Sluggishness 26.62 9.60 62 206427 4629 46474944
Discomfort 26.58 9.60 111 206378 46559 46433014
Blood bilirubin increased 26.54 9.60 71 206418 34113 46445460
Leukopenia 26.48 9.60 185 206304 68158 46411415
Suspected counterfeit product 26.43 9.60 17 206472 308 46479265
Hepatic function abnormal 26.34 9.60 72 206417 34349 46445224
Arthritis 26.31 9.60 217 206272 77099 46402474
Feeling of despair 26.21 9.60 36 206453 1769 46477804
Injection site erythema 26.19 9.60 207 206282 74220 46405353
Wound 26.15 9.60 99 206390 42703 46436870
Dyspnoea 26.06 9.60 1946 204543 513602 45965971
Cellulitis 25.91 9.60 193 206296 70095 46409478
Head injury 25.75 9.60 192 206297 24444 46455129
Haemoglobin decreased 25.74 9.60 408 206081 128541 46351032
Panic disorder 25.69 9.60 43 206446 2518 46477055
Road traffic accident 25.54 9.60 186 206303 23505 46456068
Cholecystitis chronic 25.50 9.60 103 206386 10396 46469177
Dysphoria 25.33 9.60 60 206429 4529 46475044
Hyperhidrosis 25.17 9.60 544 205945 88764 46390809
Drug detoxification 25.16 9.60 14 206475 192 46479381
Neurotoxicity 24.71 9.60 15 206474 13702 46465871
Acute kidney injury 24.71 9.60 825 205664 235030 46244543
Nightmare 24.45 9.60 141 206348 16457 46463116
Pneumocystis jirovecii pneumonia 24.38 9.60 19 206470 15229 46464344
Anhedonia 24.00 9.60 100 206389 10235 46469338
Poverty of speech 23.95 9.60 15 206474 259 46479314
Myelosuppression 23.78 9.60 3 206486 7700 46471873
Condition aggravated 22.97 9.60 869 205620 244183 46235390
Transplant rejection 22.83 9.60 7 206482 9589 46469984
Alcohol poisoning 22.65 9.60 38 206451 2230 46477343
Helicobacter infection 22.34 9.60 12 206477 11724 46467849
Injection site swelling 22.30 9.60 97 206392 40230 46439343
Red blood cell sedimentation rate increased 22.29 9.60 42 206447 22847 46456726
Hyponatraemic encephalopathy 22.19 9.60 14 206475 245 46479328
Therapy non-responder 22.14 9.60 100 206389 41052 46438521
Benzodiazepine drug level abnormal 22.13 9.60 5 206484 0 46479573
Psychomotor retardation 22.05 9.60 46 206443 3187 46476386
Inflammation 22.00 9.60 126 206363 48655 46430918
Emotional distress 21.95 9.60 220 206269 30487 46449086
Anticholinergic syndrome 21.80 9.60 33 206456 1773 46477800
Bronchiectasis 21.80 9.60 7 206482 9309 46470264
Urinary retention 21.76 9.60 193 206296 25868 46453705
Delirium 21.65 9.60 256 206233 36972 46442601
Hip arthroplasty 21.65 9.60 29 206460 18083 46461490
Pregnancy 21.34 9.60 56 206433 27081 46452492
Gastrointestinal haemorrhage 21.25 9.60 229 206260 77144 46402429
Tonic clonic movements 21.11 9.60 26 206463 1146 46478427
Acquired amegakaryocytic thrombocytopenia 21.09 9.60 6 206483 9 46479564
Dermatitis allergic 21.06 9.60 15 206474 12588 46466985
Osteonecrosis of jaw 20.74 9.60 80 206409 34322 46445251
Necrosis ischaemic 20.74 9.60 22 206467 823 46478750
Hypersomnia 20.72 9.60 128 206361 15311 46464262
Hallucination, gustatory 20.59 9.60 9 206480 70 46479503
Suicidal behaviour 20.54 9.60 38 206451 2410 46477163
Wheezing 20.44 9.60 145 206344 53241 46426332
Blood pressure fluctuation 20.22 9.60 68 206421 30380 46449193
COVID-19 19.99 9.60 32 206457 18543 46461030
Disease progression 19.89 9.60 284 206205 91016 46388557
Face injury 19.88 9.60 40 206449 2701 46476872
Speech disorder 19.86 9.60 246 206243 35921 46443652
Drug withdrawal convulsions 19.85 9.60 27 206462 1314 46478259
Hallucinations, mixed 19.83 9.60 49 206440 3800 46475773
Urticaria 19.69 9.60 385 206104 117507 46362066
Multiple organ dysfunction syndrome 19.53 9.60 141 206348 51569 46428004
Pleural effusion 19.52 9.60 254 206235 82698 46396875
Tubulointerstitial nephritis and uveitis syndrome 19.43 9.60 10 206479 116 46479457
Graft versus host disease 19.32 9.60 3 206486 6585 46472988
Distributive shock 19.28 9.60 17 206472 504 46479069
Drug eruption 19.18 9.60 41 206448 21288 46458285
Metastases to liver 19.02 9.60 36 206453 19549 46460024
Dysarthria 18.87 9.60 251 206238 37247 46442326
Fear 18.61 9.60 129 206360 16043 46463530
Toxicologic test abnormal 18.59 9.60 19 206470 680 46478893
Gastrointestinal disorder 18.58 9.60 171 206318 59405 46420168
Septic shock 18.57 9.60 165 206324 57728 46421845
Peritonitis 18.47 9.60 40 206449 20674 46458899
Liver function test abnormal 18.42 9.60 125 206364 46362 46433211
Cutaneous T-cell dyscrasia 18.33 9.60 8 206481 62 46479511
Post-traumatic stress disorder 18.24 9.60 49 206440 3999 46475574
Electrocardiogram QRS complex prolonged 17.93 9.60 59 206430 5390 46474183
Bipolar disorder 17.90 9.60 71 206418 7106 46472467
Inadequate analgesia 17.90 9.60 39 206450 2785 46476788
Feeling jittery 17.87 9.60 96 206393 10912 46468661
Tarsal tunnel syndrome 17.78 9.60 18 206471 637 46478936
Tumour lysis syndrome 17.72 9.60 5 206484 7231 46472342
Adverse drug reaction 17.72 9.60 119 206370 44243 46435330
Live birth 17.65 9.60 12 206477 10318 46469255
Alanine aminotransferase increased 17.59 9.60 280 206209 88171 46391402
Gun shot wound 17.59 9.60 9 206480 103 46479470
Psoriatic arthropathy 17.49 9.60 92 206397 36287 46443286
Productive cough 17.40 9.60 142 206347 50573 46429000
Ascites 17.32 9.60 93 206396 36491 46443082
Electrocardiogram QT prolonged 17.24 9.60 321 206168 51004 46428569
Interstitial lung disease 17.20 9.60 154 206335 53795 46425778
Stress 17.18 9.60 322 206167 51229 46428344
Acute myeloid leukaemia 17.15 9.60 27 206462 15751 46463822
Panic reaction 16.97 9.60 45 206444 3644 46475929
Blood lactic acid 16.94 9.60 9 206480 112 46479461
Breast cancer 16.76 9.60 125 206364 45393 46434180
Toxic epidermal necrolysis 16.75 9.60 47 206442 22231 46457342
Pain in extremity 16.66 9.60 955 205534 257725 46221848
Logorrhoea 16.60 9.60 34 206455 2325 46477248
Burn oesophageal 16.52 9.60 10 206479 162 46479411
Obstructive airways disorder 16.52 9.60 21 206468 13391 46466182
Haemorrhage 16.47 9.60 159 206330 54710 46424863
Substance dependence 16.38 9.60 11 206478 215 46479358
Diabetic ketoacidosis 16.38 9.60 35 206454 18175 46461398
Hallucination 16.30 9.60 311 206178 49640 46429933
Drug withdrawal syndrome neonatal 16.27 9.60 30 206459 1898 46477675
No adverse event 16.21 9.60 87 206402 34144 46445429
Tension 16.17 9.60 38 206451 2854 46476719
Death of relative 16.16 9.60 11 206478 220 46479353
Stomatitis 16.11 9.60 209 206280 68088 46411485
Serotonin syndrome 16.11 9.60 171 206318 24049 46455524
Injection site pain 16.10 9.60 356 206133 106796 46372777
Blood pressure systolic increased 16.06 9.60 69 206420 28718 46450855
Panniculitis 15.84 9.60 3 206486 5701 46473872
Multiple injuries 15.82 9.60 30 206459 1939 46477634
Brugada syndrome 15.78 9.60 11 206478 229 46479344
Multiple sclerosis relapse 15.76 9.60 268 206221 41857 46437716
Aplastic anaemia 15.66 9.60 6 206483 7147 46472426
Wrong rate 15.64 9.60 7 206482 58 46479515
Cardio-respiratory arrest neonatal 15.48 9.60 4 206485 3 46479570
Erythema 15.31 9.60 498 205991 142322 46337251
Foot deformity 15.29 9.60 28 206461 15397 46464176
Localised infection 15.23 9.60 54 206435 23747 46455826
Electrocardiogram QRS complex shortened 15.22 9.60 13 206476 369 46479204
Haemophagocytic lymphohistiocytosis 15.20 9.60 9 206480 8333 46471240
Nodular rash 15.18 9.60 10 206479 189 46479384
Therapeutic response decreased 15.17 9.60 120 206369 43025 46436548
White blood cell count decreased 15.16 9.60 379 206110 111852 46367721
Mood altered 15.11 9.60 104 206385 12903 46466670
Oropharyngeal pain 15.01 9.60 234 206255 73934 46405639
Major depression 14.97 9.60 64 206425 6626 46472947
Pharyngitis 14.83 9.60 35 206454 17548 46462025
Neuroleptic malignant syndrome 14.79 9.60 92 206397 11030 46468543
Neonatal behavioural syndrome 14.77 9.60 6 206483 38 46479535
Bradycardia 14.76 9.60 391 206098 65907 46413666
Hallucination, visual 14.74 9.60 132 206357 17741 46461832
Osteoporosis 14.72 9.60 112 206377 40496 46439077
Waxy flexibility 14.68 9.60 8 206481 105 46479468
Alcohol use 14.66 9.60 33 206456 2409 46477164
Premature labour 14.65 9.60 17 206472 11282 46468291
Cerebral haemorrhage 14.63 9.60 70 206419 28301 46451272
Alkalosis hypochloraemic 14.54 9.60 9 206480 152 46479421
Mental disability 14.49 9.60 8 206481 108 46479465
Impaired healing 14.45 9.60 99 206390 36644 46442929
Cerebral microangiopathy 14.31 9.60 10 206479 209 46479364
Pneumonitis 14.15 9.60 71 206418 28349 46451224
Basal cell carcinoma 14.12 9.60 45 206444 20442 46459131
Incoherent 14.09 9.60 48 206441 4464 46475109
Theft 14.08 9.60 7 206482 75 46479498
Sleep disorder due to general medical condition, insomnia type 14.08 9.60 3 206486 5246 46474327
Formication 14.07 9.60 44 206445 3912 46475661
Metastases to bone 13.79 9.60 36 206453 17440 46462133
Substance use 13.76 9.60 13 206476 422 46479151
Therapeutic response unexpected 13.74 9.60 117 206372 15499 46464074
Self-injurious ideation 13.72 9.60 31 206458 2269 46477304
Purging 13.69 9.60 6 206483 47 46479526
Atrioventricular septal defect 13.68 9.60 10 206479 225 46479348
Partner stress 13.62 9.60 9 206480 171 46479402
Obsessive-compulsive personality disorder 13.62 9.60 5 206484 23 46479550
Uveitis 13.52 9.60 11 206478 8630 46470943
Clostridium difficile infection 13.50 9.60 61 206428 25042 46454531
Blood lactate dehydrogenase increased 13.46 9.60 46 206443 20454 46459119
Drug-induced liver injury 13.43 9.60 62 206427 25306 46454267
Torsade de pointes 13.43 9.60 96 206393 12058 46467515
Restlessness 13.32 9.60 172 206317 25352 46454221
Delusion 13.32 9.60 90 206399 11098 46468475
Stupor 13.32 9.60 40 206449 3480 46476093
LDL/HDL ratio increased 13.28 9.60 3 206486 0 46479573
Blood count abnormal 13.23 9.60 38 206451 17840 46461733
Normal newborn 13.20 9.60 5 206484 5996 46473577
Cyanosis 13.19 9.60 118 206371 15853 46463720
Drug screen negative 13.19 9.60 12 206477 371 46479202
Newborn persistent pulmonary hypertension 13.18 9.60 7 206482 87 46479486
Vascular headache 13.17 9.60 6 206483 52 46479521
Sensitivity to weather change 13.17 9.60 4 206485 5512 46474061
Pain 13.09 9.60 1880 204609 475068 46004505
Coma scale 13.07 9.60 6 206483 53 46479520
Laryngomalacia 13.07 9.60 6 206483 53 46479520
Muscle spasms 12.88 9.60 667 205822 122446 46357127
Faecal vomiting 12.86 9.60 15 206474 624 46478949
Pruritus 12.79 9.60 911 205578 241441 46238132
Divorced 12.74 9.60 4 206485 10 46479563
Body temperature decreased 12.71 9.60 25 206464 13384 46466189
Somnambulism 12.70 9.60 50 206439 4987 46474586
Bone marrow failure 12.66 9.60 78 206411 29591 46449982
Pneumonia streptococcal 12.61 9.60 25 206464 1670 46477903
Ataxia 12.59 9.60 105 206384 13825 46465748
Craniosynostosis 12.58 9.60 8 206481 142 46479431
Brain death 12.55 9.60 34 206455 2789 46476784
Caesarean section 12.50 9.60 35 206454 16568 46463005
Anxiety disorder 12.44 9.60 39 206450 3472 46476101
Cerebral infarction 12.43 9.60 57 206432 23309 46456264
Osteonecrosis 12.43 9.60 65 206424 25679 46453894
Tendonitis 12.38 9.60 28 206461 14249 46465324
Phobia 12.31 9.60 11 206478 332 46479241
Retrograde amnesia 12.31 9.60 11 206478 332 46479241
Lupus-like syndrome 12.26 9.60 10 206479 7834 46471739
Arthritis bacterial 12.25 9.60 5 206484 5731 46473842
Skin necrosis 12.21 9.60 12 206477 8592 46470981
Haematemesis 12.15 9.60 76 206413 28730 46450843
Ulcer 12.13 9.60 38 206451 17354 46462219
Osteoarthritis 12.11 9.60 197 206292 61828 46417745
Depressed mood 12.11 9.60 211 206278 33108 46446465
Learning disorder 12.03 9.60 12 206477 417 46479156
Hypochloraemia 12.02 9.60 26 206463 1847 46477726
Exposure via inhalation 12.01 9.60 5 206484 34 46479539
Gambling disorder 12 9.60 21 206468 1275 46478298
Cholestasis 11.91 9.60 176 206313 26717 46452856
Prothrombin level decreased 11.75 9.60 14 206475 596 46478977
Congenital central nervous system anomaly 11.65 9.60 11 206478 357 46479216
Influenza 11.64 9.60 303 206186 88967 46390606
Asthenia 11.64 9.60 1558 204931 309517 46170056
Thrombocytopenia 11.59 9.60 450 206039 126131 46353442
Cutaneous lymphoma 11.58 9.60 8 206481 164 46479409
Injection site pruritus 11.57 9.60 116 206373 39627 46439946
Hyperreflexia 11.55 9.60 50 206439 5204 46474369
Homicidal ideation 11.55 9.60 25 206464 1777 46477796
Blood pressure diastolic increased 11.53 9.60 6 206483 5968 46473605
Suspiciousness 11.52 9.60 11 206478 362 46479211
Gallbladder hypofunction 11.51 9.60 13 206476 522 46479051
Performance status decreased 11.51 9.60 36 206453 3201 46476372
Injection site reaction 11.44 9.60 146 206343 47703 46431870
Palmar-plantar erythrodysaesthesia syndrome 11.42 9.60 49 206440 20402 46459171
Conversion disorder 11.39 9.60 24 206465 1674 46477899
Device related infection 11.39 9.60 51 206438 20990 46458583
Throat irritation 11.30 9.60 78 206411 28823 46450750
Thrombophlebitis superficial 11.30 9.60 48 206441 4955 46474618
Tubulointerstitial nephritis 11.26 9.60 31 206458 14757 46464816
Limb fracture 11.21 9.60 3 206486 3 46479570
Pelvic floor dysfunction 11.21 9.60 3 206486 3 46479570
Prothrombin level increased 11.20 9.60 9 206480 234 46479339
Intentional product use issue 11.20 9.60 165 206324 52615 46426958
Emotional disorder 11.20 9.60 93 206396 12231 46467342
Rhinorrhoea 11.19 9.60 146 206343 47519 46432054
Blastocystis infection 11.14 9.60 4 206485 17 46479556
Grip strength decreased 11.10 9.60 13 206476 8593 46470980
Migraine 11.05 9.60 396 206093 69630 46409943
Nephropathy toxic 11.04 9.60 10 206479 7444 46472129
Cardio-respiratory distress 10.97 9.60 7 206482 125 46479448
Balance disorder 10.97 9.60 368 206121 64153 46415420
Product substitution issue 10.89 9.60 108 206381 14923 46464650
Joint effusion 10.83 9.60 23 206466 11972 46467601
Fluid overload 10.82 9.60 73 206416 27112 46452461
Hyponatraemia 10.80 9.60 550 205939 100782 46378791
Rhabdomyolysis 10.77 9.60 252 206237 41657 46437916
Postmortem blood drug level abnormal 10.76 9.60 10 206479 318 46479255
Tuberculosis 10.75 9.60 18 206471 10247 46469326
Liver disorder 10.73 9.60 109 206380 37137 46442436
Atrial fibrillation 10.67 9.60 363 206126 103227 46376346
Perseveration 10.58 9.60 9 206480 254 46479319
Drug screen false positive 10.55 9.60 16 206473 861 46478712
Violence-related symptom 10.49 9.60 11 206478 406 46479167
Myelodysplastic syndrome 10.49 9.60 35 206454 15676 46463897
Crime 10.46 9.60 4 206485 21 46479552
Incision site cellulitis 10.43 9.60 6 206483 88 46479485
Cardiac valve disease 10.41 9.60 40 206449 3944 46475629
Erythrodermic psoriasis 10.39 9.60 16 206473 873 46478700
Injection site bruising 10.38 9.60 104 206385 35532 46444041
Infective pulmonary exacerbation of cystic fibrosis 10.38 9.60 20 206469 10787 46468786
Coagulation factor V level decreased 10.33 9.60 10 206479 335 46479238
Bone density decreased 10.31 9.60 17 206472 9735 46469838
Venoocclusive liver disease 10.30 9.60 3 206486 4248 46475325
Hospitalisation 10.27 9.60 208 206281 63177 46416396
Body temperature increased 10.27 9.60 66 206423 24795 46454778
Hypercalcaemia 10.24 9.60 53 206436 20993 46458580
Peritonitis bacterial 10.19 9.60 14 206475 8639 46470934
Hypersensitivity vasculitis 10.19 9.60 3 206486 4218 46475355
Hypocalcaemia 10.13 9.60 73 206416 26712 46452861
Mental status changes 10.09 9.60 230 206259 37858 46441715
Counterfeit product administered 10.02 9.60 4 206485 24 46479549
Cardioplegia 10.01 9.60 3 206486 6 46479567
Hyperinsulinism 10.01 9.60 3 206486 6 46479567
Slow speech 10.00 9.60 20 206469 1344 46478229
Corneal reflex decreased 9.99 9.60 7 206482 147 46479426
Ocular hyperaemia 9.95 9.60 49 206440 19661 46459912
Gamma-glutamyltransferase increased 9.94 9.60 91 206398 31649 46447924
Obsessive thoughts 9.92 9.60 12 206477 519 46479054
Encephalitis 9.88 9.60 11 206478 7437 46472136
Oligohydramnios 9.81 9.60 6 206483 5459 46474114
Jaundice 9.79 9.60 81 206408 28764 46450809
Purpura senile 9.73 9.60 13 206476 622 46478951
Morbid thoughts 9.73 9.60 12 206477 530 46479043
Lip swelling 9.71 9.60 69 206420 25326 46454247
Beta haemolytic streptococcal infection 9.68 9.60 24 206465 1865 46477708
Tendon disorder 9.66 9.60 5 206484 4990 46474583
Adrenal insufficiency 9.64 9.60 28 206461 13096 46466477
Persecutory delusion 9.63 9.60 29 206460 2526 46477047

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug abuse 6918.48 10.49 3935 95357 78137 29775049
Completed suicide 1824.42 10.49 1931 97361 97561 29755625
Toxicity to various agents 1806.90 10.49 2554 96738 174629 29678557
Respiratory arrest 1707.61 10.49 1114 98178 28144 29825042
Poisoning 1355.16 10.49 690 98602 10692 29842494
Cardio-respiratory arrest 918.33 10.49 1038 98254 56268 29796918
Cardiac arrest 824.02 10.49 1257 98035 91593 29761593
Intentional product misuse 641.91 10.49 678 98614 33989 29819197
Sopor 573.98 10.49 391 98901 10600 29842586
Drug dependence 572.07 10.49 511 98781 20784 29832402
Suicide attempt 497.98 10.49 611 98681 36086 29817100
Overdose 453.88 10.49 917 98375 83420 29769766
Coma 440.27 10.49 604 98688 39845 29813341
Intentional overdose 341.11 10.49 543 98749 40938 29812248
Poisoning deliberate 329.66 10.49 219 99073 5685 29847501
Anxiety 259.26 10.49 769 98523 89102 29764084
Exposure via ingestion 247.35 10.49 136 99156 2475 29850711
Intentional self-injury 200.88 10.49 236 99056 13296 29839890
Prescription form tampering 195.67 10.49 73 99219 497 29852689
Accidental overdose 178.07 10.49 259 99033 18016 29835170
Withdrawal syndrome 173.33 10.49 200 99092 11050 29842136
Drug withdrawal syndrome 167.79 10.49 263 99029 19546 29833640
Somnolence 165.40 10.49 697 98595 96066 29757120
Substance abuse 145.11 10.49 146 99146 6894 29846292
Drug abuser 143.31 10.49 118 99174 4283 29848903
Drug use disorder 133.68 10.49 100 99192 3148 29850038
Pyrexia 115.66 10.49 543 98749 293946 29559240
Miosis 114.37 10.49 135 99157 7641 29845545
Death 107.58 10.49 1720 97572 355563 29497623
Bradypnoea 106.60 10.49 71 99221 1850 29851336
Febrile neutropenia 106.44 10.49 118 99174 106575 29746611
Depression 98.35 10.49 573 98719 89864 29763322
Suicidal ideation 95.48 10.49 300 98992 35814 29817372
Agitation 91.87 10.49 389 98903 53684 29799502
Off label use 90.67 10.49 472 98820 248818 29604368
Drug screen positive 90.10 10.49 91 99201 4316 29848870
Pneumonia 85.62 10.49 704 98588 333602 29519584
Insomnia 80.18 10.49 557 98735 92779 29760407
Bradyphrenia 79.60 10.49 81 99211 3876 29849310
Accidental death 76.75 10.49 60 99232 2019 29851167
Counterfeit product administered 68.58 10.49 25 99267 158 29853028
Drug ineffective 68.30 10.49 761 98531 339626 29513560
Renal impairment 67.74 10.49 109 99183 84075 29769111
Respiratory depression 67.62 10.49 130 99162 11373 29841813
Sepsis 66.47 10.49 255 99037 146140 29707046
Unresponsive to stimuli 63.08 10.49 212 99080 26207 29826979
Panic attack 61.02 10.49 106 99186 8575 29844611
Postmortem blood drug level abnormal 56.41 10.49 23 99269 204 29852982
Neutropenia 56.36 10.49 227 99065 128313 29724873
Infection 55.67 10.49 109 99183 77965 29775221
Treatment failure 53.41 10.49 24 99268 34655 29818531
Toxicologic test abnormal 50.13 10.49 29 99263 584 29852602
Cytomegalovirus infection 50.01 10.49 9 99283 23665 29829521
C-reactive protein increased 49.16 10.49 43 99249 43430 29809756
Cough 48.92 10.49 232 99060 125410 29727776
Lower respiratory tract infection 46.95 10.49 15 99277 26699 29826487
Amnesia 46.05 10.49 181 99111 24140 29829046
Anaemia 45.65 10.49 455 98837 207537 29645649
Hepatic function abnormal 45.63 10.49 43 99249 41902 29811284
Interstitial lung disease 45.59 10.49 81 99211 60116 29793070
Diarrhoea 45.53 10.49 807 98485 333296 29519890
Rheumatoid arthritis 45.09 10.49 42 99250 41155 29812031
Drug tolerance 44.85 10.49 45 99247 2117 29851069
Acute kidney injury 43.39 10.49 643 98649 273199 29579987
Rash 42.84 10.49 418 98874 191471 29661715
Infusion related reaction 42.49 10.49 43 99249 40521 29812665
Aggression 42.12 10.49 237 99055 36670 29816516
Platelet count decreased 41.87 10.49 195 99097 105934 29747252
Narcotic bowel syndrome 41.00 10.49 16 99276 125 29853061
Self-medication 40.85 10.49 44 99248 2250 29850936
Product use in unapproved indication 40.51 10.49 118 99174 73575 29779611
Depressed level of consciousness 40.08 10.49 240 99052 37982 29815204
Irritability 40.03 10.49 167 99125 22883 29830303
Blood creatinine increased 37.77 10.49 165 99127 91210 29761976
Tremor 36.35 10.49 396 98896 74967 29778219
Respiratory rate decreased 36.23 10.49 37 99255 1778 29851408
Cardiac failure 36.10 10.49 148 99144 83270 29769916
Abnormal behaviour 35.76 10.49 174 99118 25449 29827737
Renal failure 35.43 10.49 266 99026 128700 29724486
Dyspnoea 35.00 10.49 840 98452 332455 29520731
Paramnesia 33.24 10.49 8 99284 6 29853180
Neutrophil count decreased 33.17 10.49 56 99236 42398 29810788
Pancytopenia 33.11 10.49 157 99135 84895 29768291
Mucosal inflammation 32.30 10.49 32 99260 30462 29822724
Abulia 31.84 10.49 20 99272 470 29852716
Pneumocystis jirovecii pneumonia 31.19 10.49 9 99283 17111 29836075
White blood cell count decreased 30.92 10.49 158 99134 83789 29769397
Analgesic drug level increased 30.84 10.49 21 99271 568 29852618
Product counterfeit 30.63 10.49 14 99278 168 29853018
Bladder dilatation 30.37 10.49 29 99263 1283 29851903
Angioedema 30.08 10.49 42 99250 34342 29818844
Anger 29.94 10.49 93 99199 11027 29842159
Road traffic accident 29.88 10.49 124 99168 16947 29836239
Haemoglobin decreased 29.62 10.49 239 99053 113859 29739327
Bone marrow failure 29.59 10.49 33 99259 29752 29823434
Nervousness 29.38 10.49 96 99196 11692 29841494
Disturbance in attention 28.56 10.49 147 99145 21982 29831204
Gastrointestinal haemorrhage 28.55 10.49 161 99131 83285 29769901
Loss of consciousness 27.87 10.49 393 98899 78982 29774204
Pulmonary congestion 27.05 10.49 96 99196 12191 29840995
Cerebral haemorrhage 26.98 10.49 42 99250 32845 29820341
Cardiac failure congestive 26.68 10.49 167 99125 84240 29768946
Drug withdrawal syndrome neonatal 26.65 10.49 42 99250 3133 29850053
Thinking abnormal 26.41 10.49 56 99236 5255 29847931
Dependence 26.32 10.49 26 99266 1200 29851986
Respiratory failure 26.03 10.49 211 99081 100431 29752755
Hyperthermia 25.85 10.49 83 99209 10016 29843170
Myocardial infarction 25.79 10.49 279 99013 125346 29727840
Panic disorder 25.38 10.49 25 99267 1150 29852036
Accident 25.24 10.49 44 99248 3569 29849617
Mydriasis 25.21 10.49 60 99232 6083 29847103
Erythema 25.12 10.49 152 99140 77299 29775887
Alcohol abuse 24.97 10.49 55 99237 5298 29847888
Disorientation 24.90 10.49 184 99108 31234 29821952
Sedation 24.90 10.49 114 99178 16259 29836927
Deafness neurosensory 24.89 10.49 35 99257 2358 29850828
Neutropenic sepsis 24.84 10.49 4 99288 11405 29841781
Lactic acidosis 24.54 10.49 41 99251 31172 29822014
Oedematous pancreatitis 24.24 10.49 15 99277 343 29852843
Condition aggravated 24.15 10.49 317 98975 137549 29715637
Acute myocardial infarction 24.11 10.49 92 99200 52847 29800339
Alcohol use 24.01 10.49 44 99248 3711 29849475
Homicide 23.99 10.49 23 99269 1023 29852163
Fluid overload 23.95 10.49 17 99275 19075 29834111
Arthralgia 23.51 10.49 313 98979 135478 29717708
Asphyxia 23.36 10.49 54 99238 5371 29847815
Hyperkalaemia 23.32 10.49 126 99166 65884 29787302
Gun shot wound 23.15 10.49 24 99268 1174 29852012
Joint swelling 23.09 10.49 79 99213 46867 29806319
Inadequate analgesia 22.98 10.49 36 99256 2672 29850514
Incorrect route of product administration 22.88 10.49 86 99206 11229 29841957
Exposure during pregnancy 22.70 10.49 75 99217 9186 29844000
Alanine aminotransferase increased 22.43 10.49 149 99143 74127 29779059
Disease progression 22.27 10.49 164 99128 79710 29773476
Generalised anxiety disorder 22.08 10.49 18 99274 644 29852542
Malignant neoplasm progression 21.83 10.49 145 99147 72142 29781044
Foetal exposure during pregnancy 21.77 10.49 57 99235 36814 29816372
Bronchopulmonary aspergillosis 21.40 10.49 7 99285 12277 29840909
Chorea 21.34 10.49 22 99270 1069 29852117
Vestibular ischaemia 21.10 10.49 6 99286 14 29853172
Drug intolerance 21.09 10.49 78 99214 45213 29807973
Stomatitis 20.98 10.49 59 99233 37220 29815966
Anaphylactic reaction 20.86 10.49 38 99254 27944 29825242
Hypersensitivity 20.86 10.49 100 99192 53928 29799258
Drug diversion 20.74 10.49 20 99272 896 29852290
Liver disorder 20.73 10.49 42 99250 29680 29823506
Atrial fibrillation 20.66 10.49 244 99048 107880 29745306
Hyperleukocytosis 20.52 10.49 26 99266 1583 29851603
Serotonin syndrome 20.48 10.49 115 99177 17776 29835410
Catatonia 20.43 10.49 45 99247 4335 29848851
Stevens-Johnson syndrome 20.29 10.49 17 99275 17539 29835647
Blood pressure fluctuation 20.16 10.49 17 99275 17486 29835700
General physical health deterioration 20.09 10.49 223 99069 99721 29753465
Hospitalisation 19.55 10.49 78 99214 44241 29808945
Feeling abnormal 19.51 10.49 280 99012 56476 29796710
Cerebral infarction 19.50 10.49 36 99256 26337 29826849
Pneumonia aspiration 19.36 10.49 201 99091 37579 29815607
Pleural effusion 19.27 10.49 155 99137 73911 29779275
Puncture site haematoma 19.16 10.49 10 99282 163 29853023
Victim of crime 19.14 10.49 12 99280 281 29852905
Dizziness 19.09 10.49 496 98796 194413 29658773
Myotonia 18.97 10.49 7 99285 46 29853140
Liver function test abnormal 18.92 10.49 47 99245 30903 29822283
Papillary muscle disorder 18.85 10.49 4 99288 0 29853186
Leukopenia 18.85 10.49 109 99183 56050 29797136
Nephropathy toxic 18.65 10.49 6 99286 10633 29842553
Psoriatic arthropathy 18.54 10.49 15 99277 15746 29837440
Leukoencephalopathy 18.53 10.49 41 99251 3961 29849225
Drug withdrawal convulsions 18.51 10.49 21 99271 1138 29852048
Contraindicated product administered 18.34 10.49 18 99274 17213 29835973
Altered state of consciousness 18.33 10.49 121 99171 19798 29833388
Pathogen resistance 18.19 10.49 3 99289 8407 29844779
Cerebral congestion 18.14 10.49 6 99286 27 29853159
Drug tolerance increased 18.09 10.49 13 99279 384 29852802
Substance abuser 17.88 10.49 8 99284 91 29853095
Pruritus 17.81 10.49 280 99012 117924 29735262
Tachyphylaxis 17.80 10.49 8 99284 92 29853094
Blood triglycerides decreased 17.79 10.49 7 99285 56 29853130
Product substitution 17.79 10.49 6 99286 29 29853157
Nasopharyngitis 17.79 10.49 118 99174 58731 29794455
Asthma 17.70 10.49 61 99231 36113 29817073
Suspected suicide 17.69 10.49 35 99257 3126 29850060
Pulmonary oedema 17.60 10.49 223 99069 43752 29809434
Aspergillus infection 17.48 10.49 6 99286 10208 29842978
Sudden death 17.35 10.49 99 99193 15393 29837793
Thrombocytopenia 17.32 10.49 335 98957 136709 29716477
Plasma cell myeloma 17.29 10.49 105 99187 53357 29799829
Urticaria 17.27 10.49 108 99184 54498 29798688
Hepatotoxicity 17.06 10.49 21 99271 18124 29835062
Psychomotor hyperactivity 17.04 10.49 63 99229 8161 29845025
Blood creatine phosphokinase 16.98 10.49 7 99285 64 29853122
Sexual dysfunction 16.91 10.49 51 99241 5950 29847236
Peritonitis 16.87 10.49 28 99264 21347 29831839
Anticholinergic syndrome 16.81 10.49 17 99275 807 29852379
Legal problem 16.79 10.49 10 99282 213 29852973
COVID-19 16.49 10.49 21 99271 17857 29835329
Ventricular tachyarrhythmia 16.40 10.49 11 99281 290 29852896
Neurotoxicity 16.19 10.49 12 99280 13170 29840016
Medication error 16.15 10.49 122 99170 20850 29832336
Osteonecrosis of jaw 16.02 10.49 23 99269 18595 29834591
Bradykinesia 16.00 10.49 34 99258 3196 29849990
Therapeutic product effect incomplete 15.92 10.49 58 99234 33776 29819410
Bacterial prostatitis 15.85 10.49 7 99285 77 29853109
Acute myeloid leukaemia 15.74 10.49 22 99270 17984 29835202
Acute hepatic failure 15.55 10.49 10 99282 11817 29841369
Gastric haemorrhage 15.46 10.49 6 99286 9461 29843725
Cyclothymic disorder 15.39 10.49 7 99285 83 29853103
Major depression 15.14 10.49 38 99254 3984 29849202
Pneumonitis 15.04 10.49 44 99248 27410 29825776
Renal tubular necrosis 15.03 10.49 17 99275 15234 29837952
Melaena 15.01 10.49 56 99236 32381 29820805
Herpes zoster 14.99 10.49 50 99242 29893 29823293
Transplant rejection 14.76 10.49 6 99286 9200 29843986
Ascites 14.74 10.49 65 99227 35856 29817330
Haemorrhage 14.64 10.49 91 99201 45988 29807198
Inflammation 14.63 10.49 32 99260 21994 29831192
Euphoric mood 14.57 10.49 39 99253 4251 29848935
Oedema peripheral 14.52 10.49 255 99037 105577 29747609
Diabetic ketoacidosis 14.51 10.49 19 99273 15967 29837219
Immune reconstitution inflammatory syndrome 14.48 10.49 6 99286 9095 29844091
Scleroderma renal crisis 14.36 10.49 7 99285 98 29853088
Impatience 14.29 10.49 10 99282 283 29852903
Cataract 14.27 10.49 32 99260 21803 29831383
Memory impairment 14.24 10.49 187 99105 36987 29816199
Lymphadenopathy 14.15 10.49 38 99254 24338 29828848
Sepsis pasteurella 14.14 10.49 3 99289 0 29853186
Respiratory acidosis 14.07 10.49 38 99254 4164 29849022
Psoriasis 14.00 10.49 83 99209 42423 29810763
Thymus disorder 13.87 10.49 4 99288 10 29853176
Drug detoxification 13.84 10.49 9 99283 225 29852961
Osteonecrosis 13.82 10.49 20 99272 16115 29837071
Drug eruption 13.79 10.49 23 99269 17503 29835683
Brachial plexus injury 13.75 10.49 7 99285 108 29853078
Circulatory collapse 13.73 10.49 29 99263 20185 29833001
Epistaxis 13.72 10.49 111 99181 52870 29800316
Troponin T increased 13.71 10.49 20 99272 1394 29851792
Hallucination, visual 13.71 10.49 96 99196 16017 29837169
Psychomotor skills impaired 13.69 10.49 24 99268 1955 29851231
Blood lactate dehydrogenase increased 13.62 10.49 30 99262 20571 29832615
Cytokine release syndrome 13.61 10.49 8 99284 9925 29843261
Amimia 13.60 10.49 4 99288 11 29853175
Amnestic disorder 13.57 10.49 8 99284 167 29853019
Hypocalcaemia 13.43 10.49 32 99260 21344 29831842
Blood alcohol increased 13.42 10.49 16 99276 915 29852271
Mania 13.37 10.49 63 99229 9091 29844095
Central nervous system necrosis 13.26 10.49 7 99285 117 29853069
Visual acuity reduced 13.22 10.49 20 99272 15826 29837360
Femoral artery aneurysm 13.16 10.49 8 99284 177 29853009
Chloasma 13.11 10.49 4 99288 13 29853173
Tumour lysis syndrome 13.10 10.49 14 99278 12871 29840315
Oedema 13.10 10.49 86 99206 42907 29810279
Hyperglycaemia 13.09 10.49 66 99226 35134 29818052
Brain oedema 13.08 10.49 78 99214 12320 29840866
Physical assault 13.00 10.49 18 99274 1195 29851991
Delirium 13.00 10.49 198 99094 40433 29812753
Aspartate aminotransferase increased 12.94 10.49 141 99151 63281 29789905
Progressive multifocal leukoencephalopathy 12.72 10.49 7 99285 9006 29844180
Tubulointerstitial nephritis 12.72 10.49 25 99267 17866 29835320
Cholangitis 12.65 10.49 5 99287 7797 29845389
Bacteraemia 12.64 10.49 20 99272 15540 29837646
Victim of homicide 12.55 10.49 7 99285 131 29853055
Slow speech 12.53 10.49 16 99276 982 29852204
Bipolar disorder 12.49 10.49 34 99258 3742 29849444
Theft 12.49 10.49 9 99283 267 29852919
Electrocardiogram QT prolonged 12.39 10.49 177 99115 35658 29817528
Adrenergic syndrome 12.31 10.49 6 99286 84 29853102
Haemoconcentration 12.30 10.49 5 99287 44 29853142
Apathy 12.30 10.49 47 99245 6185 29847001
Prothrombin time shortened 12.27 10.49 20 99272 1535 29851651
Haematochezia 12.26 10.49 65 99227 34157 29819029
Incision site pain 12.21 10.49 23 99269 1981 29851205
Panic reaction 12.19 10.49 19 99273 1404 29851782
Sluggishness 12.15 10.49 30 99262 3113 29850073
Conversion disorder 12.09 10.49 10 99282 365 29852821
Shoplifting 12.07 10.49 3 99289 3 29853183
Myositis 12.05 10.49 10 99282 10367 29842819
Prostate cancer 11.99 10.49 40 99252 23917 29829269
Judgement impaired 11.99 10.49 13 99279 670 29852516
Peritonitis bacterial 11.98 10.49 12 99280 11366 29841820
Peripheral swelling 11.97 10.49 137 99155 60937 29792249
Hypothermia 11.96 10.49 63 99229 9504 29843682
Personality change 11.95 10.49 38 99254 4562 29848624
Cardio-respiratory distress 11.84 10.49 7 99285 147 29853039
Hypoventilation 11.84 10.49 29 99263 2994 29850192
Anamnestic reaction 11.83 10.49 5 99287 49 29853137
Acute stress disorder 11.76 10.49 7 99285 149 29853037
Product communication issue 11.74 10.49 5 99287 50 29853136
Blood pressure systolic increased 11.73 10.49 20 99272 15090 29838096
Lip swelling 11.72 10.49 15 99277 12729 29840457
Infective pulmonary exacerbation of cystic fibrosis 11.61 10.49 7 99285 8565 29844621
Erythema multiforme 11.57 10.49 6 99286 7979 29845207
Osteoporosis 11.51 10.49 11 99281 10652 29842534
Hyporesponsive to stimuli 11.42 10.49 15 99277 947 29852239
Congenital central nervous system anomaly 11.36 10.49 10 99282 398 29852788
Paranoia 11.34 10.49 65 99227 10123 29843063
Mobility decreased 11.31 10.49 46 99246 25953 29827233
Therapeutic response decreased 11.29 10.49 42 99250 24307 29828879
Heart rate decreased 11.25 10.49 34 99258 20960 29832226
Septic shock 11.21 10.49 146 99146 63461 29789725
Transaminases increased 11.18 10.49 40 99252 23417 29829769
Haemolysis 11.14 10.49 5 99287 7226 29845960
Device related infection 11.07 10.49 25 99267 16990 29836196
Jaundice 10.93 10.49 63 99229 32423 29820763
Upper gastrointestinal haemorrhage 10.88 10.49 37 99255 21991 29831195
Benign mesenteric neoplasm 10.86 10.49 3 99289 6 29853180
Inappropriate schedule of product administration 10.86 10.49 82 99210 39646 29813540
Cardiorenal syndrome 10.74 10.49 13 99279 755 29852431
Tendon rupture 10.70 10.49 5 99287 7059 29846127
Visceral congestion 10.70 10.49 11 99281 533 29852653
Self esteem decreased 10.66 10.49 11 99281 535 29852651
Exposure via inhalation 10.58 10.49 5 99287 65 29853121
Drug screen negative 10.58 10.49 8 99284 256 29852930
Urinary tract infection 10.58 10.49 176 99116 73483 29779703
Benzodiazepine drug level 10.55 10.49 3 99289 7 29853179
Urosepsis 10.54 10.49 12 99280 10720 29842466
Liver function test increased 10.52 10.49 13 99279 11203 29841983
Tension 10.52 10.49 19 99273 1584 29851602

Pharmacologic Action:

SourceCodeDescription
ATC N05BA12 NERVOUS SYSTEM
PSYCHOLEPTICS
ANXIOLYTICS
Benzodiazepine derivatives
FDA CS M0002356 Benzodiazepines
FDA EPC N0000175694 Benzodiazepine
CHEBI has role CHEBI:35474 minor tranquilisers
CHEBI has role CHEBI:35623 antiepileptic
CHEBI has role CHEBI:35703 xenobiotic
CHEBI has role CHEBI:35717 sedatives
CHEBI has role CHEBI:51371 muscle relaxants
CHEBI has role CHEBI:51373 gamma-aminobutyric acid receptor agonists
MeSH PA D014151 Anti-Anxiety Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D018682 GABA Agents
MeSH PA D018757 GABA Modulators
MeSH PA D006993 Hypnotics and Sedatives
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D011619 Psychotropic Drugs
MeSH PA D014149 Tranquilizing Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Generalized anxiety disorder indication 21897009 DOID:14320
Anxiety indication 48694002
Mixed anxiety and depressive disorder indication 231504006
Panic disorder indication 371631005 DOID:594
Insomnia off-label use 193462001
Suicidal thoughts contraindication 6471006
Asthenia contraindication 13791008
Alcohol intoxication contraindication 25702006
Depressive disorder contraindication 35489007
Substance abuse contraindication 66214007
Sleep apnea contraindication 73430006 DOID:0050847
Open-angle glaucoma contraindication 84494001 DOID:1067
Kidney disease contraindication 90708001 DOID:557
Disease of liver contraindication 235856003 DOID:409
Syncope contraindication 271594007
Pregnancy, function contraindication 289908002
Angle-closure glaucoma contraindication 392291006 DOID:13550
Breastfeeding (mother) contraindication 413712001
Chronic lung disease contraindication 413839001
Obesity contraindication 414916001 DOID:9970
Central nervous system depression contraindication 418072004
Smokes tobacco daily contraindication 449868002

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 6.15 Basic
pKa2 4.9 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
GABA-A receptor alpha-2/beta-3/gamma-2 Ion channel POSITIVE ALLOSTERIC MODULATOR EC50 7.92 WOMBAT-PK CHEMBL
GABA-A receptor alpha-3/beta-3/gamma-2 Ion channel POSITIVE ALLOSTERIC MODULATOR EC50 7.16 WOMBAT-PK CHEMBL
GABA-A receptor alpha-5/beta-3/gamma-2 Ion channel POSITIVE ALLOSTERIC MODULATOR EC50 8 WOMBAT-PK CHEMBL
GABA-A receptor alpha-1/beta-2/gamma-2 Ion channel POSITIVE ALLOSTERIC MODULATOR EC50 7.43 WOMBAT-PK CHEMBL
Cytochrome P450 3A4 Enzyme Ki 3.85 WOMBAT-PK
Bromodomain-containing protein 4 Unclassified Kd 5.61 CHEMBL
Platelet-activating factor receptor GPCR Ki 5.46 PDSP
Cholecystokinin receptor type A GPCR IC50 4.19 CHEMBL

External reference:

IDSource
YU55MQ3IZY UNII
D00225 KEGG_DRUG
C0002333 UMLSCUI
CHEBI:2611 CHEBI
08H PDB_CHEM_ID
CHEMBL661 ChEMBL_ID
DB00404 DRUGBANK_ID
D000525 MESH_DESCRIPTOR_UI
2118 PUBCHEM_CID
3426 INN_ID
7111 IUPHAR_LIGAND_ID
202363 RXNORM
1327 MMSL
1885 MMSL
4153 MMSL
d00168 MMSL
001464 NDDF
111127002 SNOMEDCT_US
386983007 SNOMEDCT_US
4018074 VANDF

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Xanax HUMAN PRESCRIPTION DRUG LABEL 1 0009-0029 TABLET 0.25 mg ORAL NDA 36 sections
Xanax HUMAN PRESCRIPTION DRUG LABEL 1 0009-0055 TABLET 0.50 mg ORAL NDA 36 sections
Xanax XR HUMAN PRESCRIPTION DRUG LABEL 1 0009-0057 TABLET, EXTENDED RELEASE 0.50 mg ORAL NDA 37 sections
Xanax XR HUMAN PRESCRIPTION DRUG LABEL 1 0009-0059 TABLET, EXTENDED RELEASE 1 mg ORAL NDA 37 sections
Xanax XR HUMAN PRESCRIPTION DRUG LABEL 1 0009-0066 TABLET, EXTENDED RELEASE 2 mg ORAL NDA 37 sections
Xanax XR HUMAN PRESCRIPTION DRUG LABEL 1 0009-0068 TABLET, EXTENDED RELEASE 3 mg ORAL NDA 37 sections
Xanax HUMAN PRESCRIPTION DRUG LABEL 1 0009-0090 TABLET 1 mg ORAL NDA 36 sections
Xanax HUMAN PRESCRIPTION DRUG LABEL 1 0009-0094 TABLET 2 mg ORAL NDA 36 sections
Alprazolam HUMAN PRESCRIPTION DRUG LABEL 1 0054-3068 SOLUTION, CONCENTRATE 1 mg ORAL ANDA 16 sections
Alprazolam HUMAN PRESCRIPTION DRUG LABEL 1 0228-2027 TABLET 0.25 mg ORAL ANDA 29 sections
Alprazolam HUMAN PRESCRIPTION DRUG LABEL 1 0228-2029 TABLET 0.50 mg ORAL ANDA 29 sections
Alprazolam HUMAN PRESCRIPTION DRUG LABEL 1 0228-2031 TABLET 1 mg ORAL ANDA 29 sections
Alprazolam HUMAN PRESCRIPTION DRUG LABEL 1 0228-2039 TABLET 2 mg ORAL ANDA 29 sections
AlprazolamExtended Release HUMAN PRESCRIPTION DRUG LABEL 1 0228-3083 TABLET, EXTENDED RELEASE 0.50 mg ORAL ANDA 31 sections
AlprazolamExtended Release HUMAN PRESCRIPTION DRUG LABEL 1 0228-3084 TABLET, EXTENDED RELEASE 1 mg ORAL ANDA 31 sections
AlprazolamExtended Release HUMAN PRESCRIPTION DRUG LABEL 1 0228-3086 TABLET, EXTENDED RELEASE 3 mg ORAL ANDA 31 sections
AlprazolamExtended Release HUMAN PRESCRIPTION DRUG LABEL 1 0228-3087 TABLET, EXTENDED RELEASE 2 mg ORAL ANDA 31 sections
Alprazolam HUMAN PRESCRIPTION DRUG LABEL 1 0228-4019 TABLET, ORALLY DISINTEGRATING 0.25 mg ORAL ANDA 32 sections
Alprazolam HUMAN PRESCRIPTION DRUG LABEL 1 0228-4022 TABLET, ORALLY DISINTEGRATING 0.50 mg ORAL ANDA 32 sections
Alprazolam HUMAN PRESCRIPTION DRUG LABEL 1 0228-4024 TABLET, ORALLY DISINTEGRATING 1 mg ORAL ANDA 32 sections
Alprazolam HUMAN PRESCRIPTION DRUG LABEL 1 0228-4025 TABLET, ORALLY DISINTEGRATING 2 mg ORAL ANDA 32 sections
Alprazolam HUMAN PRESCRIPTION DRUG LABEL 1 0615-8215 TABLET 0.25 mg ORAL ANDA 29 sections
Alprazolam HUMAN PRESCRIPTION DRUG LABEL 1 0615-8216 TABLET 0.50 mg ORAL ANDA 29 sections
Alprazolam HUMAN PRESCRIPTION DRUG LABEL 1 0615-8295 TABLET 1 mg ORAL ANDA 29 sections
Alprazolam HUMAN PRESCRIPTION DRUG LABEL 1 0781-1061 TABLET 0.25 mg ORAL ANDA 33 sections
Alprazolam HUMAN PRESCRIPTION DRUG LABEL 1 0781-1077 TABLET 0.50 mg ORAL ANDA 33 sections
Alprazolam HUMAN PRESCRIPTION DRUG LABEL 1 0781-1079 TABLET 1 mg ORAL ANDA 33 sections
Alprazolam HUMAN PRESCRIPTION DRUG LABEL 1 0781-1089 TABLET 2 mg ORAL ANDA 33 sections
Alprazolam HUMAN PRESCRIPTION DRUG LABEL 1 0904-5858 TABLET 0.25 mg ORAL ANDA 30 sections
Alprazolam HUMAN PRESCRIPTION DRUG LABEL 1 0904-5859 TABLET 0.50 mg ORAL ANDA 30 sections