Stem definition | Drug id | CAS RN |
---|---|---|
diazepam derivatives | 136 | 28981-97-7 |
Dose | Unit | Route |
---|---|---|
1 | mg | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 0.07 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 20 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 0.46 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 88 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 0.80 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 0.74 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.29 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 12 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Oct. 16, 1981 | FDA | PHARMACIA AND UPJOHN |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug abuse | 5353.45 | 9.74 | 3303 | 218035 | 56543 | 50327243 |
Completed suicide | 3822.37 | 9.74 | 3725 | 217613 | 128164 | 50255622 |
Sopor | 1862.63 | 9.74 | 1132 | 220206 | 18747 | 50365039 |
Toxicity to various agents | 1645.35 | 9.74 | 3158 | 218180 | 209341 | 50174445 |
Respiratory arrest | 1279.06 | 9.74 | 1056 | 220282 | 28953 | 50354833 |
Poisoning | 1090.69 | 9.74 | 679 | 220659 | 11750 | 50372036 |
Suicide attempt | 949.50 | 9.74 | 1151 | 220187 | 50581 | 50333205 |
Cardio-respiratory arrest | 866.09 | 9.74 | 1122 | 220216 | 52770 | 50331016 |
Intentional overdose | 815.02 | 9.74 | 1176 | 220162 | 61328 | 50322458 |
Cardiac arrest | 766.22 | 9.74 | 1339 | 219999 | 82312 | 50301474 |
Drug dependence | 638.02 | 9.74 | 594 | 220744 | 19165 | 50364621 |
Coma | 590.34 | 9.74 | 963 | 220375 | 55916 | 50327870 |
Poisoning deliberate | 584.68 | 9.74 | 388 | 220950 | 7524 | 50376262 |
Overdose | 566.33 | 9.74 | 1308 | 220030 | 98419 | 50285367 |
Pemphigus | 507.71 | 9.74 | 3 | 221335 | 120163 | 50263623 |
Contraindicated product administered | 484.42 | 9.74 | 46 | 221292 | 148912 | 50234874 |
Synovitis | 449.89 | 9.74 | 22 | 221316 | 123843 | 50259943 |
Somnolence | 414.02 | 9.74 | 1553 | 219785 | 153432 | 50230354 |
Intentional self-injury | 403.96 | 9.74 | 502 | 220836 | 22610 | 50361176 |
Drug intolerance | 391.38 | 9.74 | 237 | 221101 | 218867 | 50164919 |
Intentional product misuse | 385.30 | 9.74 | 715 | 220623 | 46019 | 50337767 |
Treatment failure | 382.02 | 9.74 | 70 | 221268 | 137567 | 50246219 |
Hand deformity | 379.93 | 9.74 | 13 | 221325 | 100186 | 50283600 |
Systemic lupus erythematosus | 370.49 | 9.74 | 81 | 221257 | 140541 | 50243245 |
Joint swelling | 355.03 | 9.74 | 330 | 221008 | 244956 | 50138830 |
Infusion related reaction | 354.28 | 9.74 | 149 | 221189 | 169408 | 50214378 |
Rheumatoid arthritis | 329.52 | 9.74 | 243 | 221095 | 202307 | 50181479 |
Drug ineffective | 329.12 | 9.74 | 2171 | 219167 | 817162 | 49566624 |
Glossodynia | 303.52 | 9.74 | 67 | 221271 | 115502 | 50268284 |
Arthropathy | 298.77 | 9.74 | 159 | 221179 | 157747 | 50226039 |
Anti-cyclic citrullinated peptide antibody positive | 287.56 | 9.74 | 4 | 221334 | 70583 | 50313203 |
Off label use | 283.57 | 9.74 | 1093 | 220245 | 473333 | 49910453 |
Anxiety | 282.45 | 9.74 | 1526 | 219812 | 176080 | 50207706 |
Maternal exposure during pregnancy | 273.93 | 9.74 | 181 | 221157 | 159597 | 50224189 |
Pericarditis | 267.50 | 9.74 | 20 | 221318 | 78669 | 50305117 |
Lower respiratory tract infection | 258.61 | 9.74 | 51 | 221287 | 95150 | 50288636 |
Depression | 250.01 | 9.74 | 1402 | 219936 | 164021 | 50219765 |
Bradyphrenia | 244.37 | 9.74 | 208 | 221130 | 5944 | 50377842 |
Alopecia | 232.14 | 9.74 | 450 | 220888 | 244597 | 50139189 |
Suicidal ideation | 230.24 | 9.74 | 646 | 220692 | 54739 | 50329047 |
Drug withdrawal syndrome | 226.08 | 9.74 | 399 | 220939 | 24682 | 50359104 |
Swelling | 222.22 | 9.74 | 334 | 221004 | 200538 | 50183248 |
Substance abuse | 187.93 | 9.74 | 151 | 221187 | 3973 | 50379813 |
Mydriasis | 182.74 | 9.74 | 229 | 221109 | 10398 | 50373388 |
Exposure via ingestion | 182.20 | 9.74 | 127 | 221211 | 2676 | 50381110 |
Panic attack | 179.90 | 9.74 | 312 | 221026 | 19030 | 50364756 |
Discomfort | 177.42 | 9.74 | 129 | 221209 | 108251 | 50275535 |
Wound | 177.02 | 9.74 | 123 | 221215 | 105671 | 50278115 |
Therapeutic product effect decreased | 176.25 | 9.74 | 201 | 221137 | 135849 | 50247937 |
Withdrawal syndrome | 174.51 | 9.74 | 292 | 221046 | 17298 | 50366488 |
Death | 173.69 | 9.74 | 2179 | 219159 | 323200 | 50060586 |
Product use issue | 173.65 | 9.74 | 240 | 221098 | 149235 | 50234551 |
Hypersensitivity | 168.67 | 9.74 | 438 | 220900 | 214723 | 50169063 |
Abdominal discomfort | 168.56 | 9.74 | 489 | 220849 | 231152 | 50152634 |
Helicobacter infection | 167.87 | 9.74 | 13 | 221325 | 49689 | 50334097 |
Nasopharyngitis | 165.19 | 9.74 | 375 | 220963 | 192552 | 50191234 |
Infection | 155.63 | 9.74 | 327 | 221011 | 172627 | 50211159 |
Hepatic enzyme increased | 152.25 | 9.74 | 228 | 221110 | 137152 | 50246634 |
Arthralgia | 152.04 | 9.74 | 1210 | 220128 | 437492 | 49946294 |
Agitation | 148.98 | 9.74 | 543 | 220795 | 52841 | 50330945 |
Peripheral swelling | 142.42 | 9.74 | 445 | 220893 | 205491 | 50178295 |
Rash | 140.53 | 9.74 | 1231 | 220107 | 436240 | 49947546 |
Loss of consciousness | 139.08 | 9.74 | 856 | 220482 | 103497 | 50280289 |
Prescription form tampering | 136.75 | 9.74 | 61 | 221277 | 507 | 50383279 |
Folliculitis | 130.40 | 9.74 | 11 | 221327 | 39214 | 50344572 |
Drug use disorder | 126.40 | 9.74 | 106 | 221232 | 2966 | 50380820 |
Tremor | 126.16 | 9.74 | 898 | 220440 | 114005 | 50269781 |
Sleep disorder due to general medical condition, insomnia type | 119.43 | 9.74 | 4 | 221334 | 31443 | 50352343 |
Victim of chemical submission | 113.86 | 9.74 | 43 | 221295 | 220 | 50383566 |
Muscle injury | 109.29 | 9.74 | 16 | 221322 | 37095 | 50346691 |
Insomnia | 106.67 | 9.74 | 1202 | 220136 | 173663 | 50210123 |
Therapeutic product effect incomplete | 100.27 | 9.74 | 153 | 221185 | 91362 | 50292424 |
C-reactive protein abnormal | 94.68 | 9.74 | 7 | 221331 | 27802 | 50355984 |
Disturbance in attention | 91.06 | 9.74 | 322 | 221016 | 30864 | 50352922 |
Impaired healing | 88.28 | 9.74 | 105 | 221233 | 69681 | 50314105 |
Bradykinesia | 86.07 | 9.74 | 96 | 221242 | 3847 | 50379939 |
Hepatocellular injury | 85.52 | 9.74 | 279 | 221059 | 25668 | 50358118 |
Musculoskeletal stiffness | 85 | 9.74 | 283 | 221055 | 128198 | 50255588 |
General physical health deterioration | 82.85 | 9.74 | 331 | 221007 | 142103 | 50241683 |
Fall | 81.18 | 9.74 | 1977 | 219361 | 332955 | 50050831 |
Drug hypersensitivity | 80.51 | 9.74 | 706 | 220632 | 250304 | 50133482 |
Accidental overdose | 80.31 | 9.74 | 227 | 221111 | 19306 | 50364480 |
C-reactive protein increased | 79.91 | 9.74 | 104 | 221234 | 66370 | 50317416 |
Nervousness | 79.44 | 9.74 | 284 | 221054 | 27367 | 50356419 |
Gastrointestinal disorder | 78.02 | 9.74 | 187 | 221151 | 94269 | 50289517 |
Drug screen positive | 78.02 | 9.74 | 85 | 221253 | 3317 | 50380469 |
Crying | 77.90 | 9.74 | 231 | 221107 | 20185 | 50363601 |
Pyrexia | 77.27 | 9.74 | 1184 | 220154 | 379019 | 50004767 |
Alcohol abuse | 76.99 | 9.74 | 65 | 221273 | 1836 | 50381950 |
Memory impairment | 76.73 | 9.74 | 602 | 220736 | 78758 | 50305028 |
Feeling abnormal | 76.64 | 9.74 | 863 | 220475 | 124629 | 50259157 |
Sinusitis | 72.86 | 9.74 | 442 | 220896 | 170116 | 50213670 |
Irritable bowel syndrome | 72.16 | 9.74 | 71 | 221267 | 51370 | 50332416 |
Miosis | 71.10 | 9.74 | 111 | 221227 | 6199 | 50377587 |
Macular degeneration | 71.08 | 9.74 | 179 | 221159 | 14209 | 50369577 |
Drug abuser | 70.75 | 9.74 | 74 | 221264 | 2754 | 50381032 |
Altered state of consciousness | 69.00 | 9.74 | 232 | 221106 | 21678 | 50362108 |
Febrile neutropenia | 68.17 | 9.74 | 210 | 221128 | 97457 | 50286329 |
Depressed level of consciousness | 67.79 | 9.74 | 424 | 220914 | 51529 | 50332257 |
Confusional state | 67.65 | 9.74 | 1166 | 220172 | 184762 | 50199024 |
Suspected suicide | 65.67 | 9.74 | 98 | 221240 | 5259 | 50378527 |
Disorientation | 65.37 | 9.74 | 318 | 221020 | 35166 | 50348620 |
Stomatitis | 65.13 | 9.74 | 226 | 221112 | 101118 | 50282668 |
Hypokinesia | 64.60 | 9.74 | 156 | 221182 | 12061 | 50371725 |
Blister | 63.72 | 9.74 | 178 | 221160 | 85240 | 50298546 |
Knee arthroplasty | 63.55 | 9.74 | 39 | 221299 | 35807 | 50347979 |
Cough | 61.42 | 9.74 | 717 | 220621 | 240547 | 50143239 |
Rheumatic fever | 61.18 | 9.74 | 3 | 221335 | 16864 | 50366922 |
Abnormal behaviour | 60.88 | 9.74 | 207 | 221131 | 19451 | 50364335 |
Ill-defined disorder | 58.30 | 9.74 | 93 | 221245 | 54561 | 50329225 |
Dependence | 57.88 | 9.74 | 55 | 221283 | 1820 | 50381966 |
Pain | 57.64 | 9.74 | 2014 | 219324 | 576889 | 49806897 |
Amnesia | 57.09 | 9.74 | 348 | 220990 | 41912 | 50341874 |
Pneumonia | 56.56 | 9.74 | 1243 | 220095 | 377158 | 50006628 |
Exposure during pregnancy | 55.73 | 9.74 | 306 | 221032 | 120709 | 50263077 |
Hip arthroplasty | 55.51 | 9.74 | 32 | 221306 | 30397 | 50353389 |
Drug resistance | 54.07 | 9.74 | 9 | 221329 | 18980 | 50364806 |
Irritability | 53.99 | 9.74 | 257 | 221081 | 28169 | 50355617 |
Product use in unapproved indication | 52.71 | 9.74 | 294 | 221044 | 115525 | 50268261 |
Vertigo | 52.21 | 9.74 | 397 | 220941 | 51435 | 50332351 |
Urinary retention | 50.62 | 9.74 | 238 | 221100 | 25952 | 50357834 |
Homicide | 50.47 | 9.74 | 27 | 221311 | 345 | 50383441 |
Aggression | 50.05 | 9.74 | 204 | 221134 | 20912 | 50362874 |
Euphoric mood | 46.62 | 9.74 | 72 | 221266 | 3983 | 50379803 |
Hallucination, auditory | 46.39 | 9.74 | 127 | 221211 | 10601 | 50373185 |
Psychomotor skills impaired | 46.34 | 9.74 | 51 | 221287 | 2013 | 50381773 |
Condition aggravated | 46.03 | 9.74 | 970 | 220368 | 296088 | 50087698 |
Abnormal dreams | 45.63 | 9.74 | 116 | 221222 | 9261 | 50374525 |
Anhedonia | 45.50 | 9.74 | 117 | 221221 | 9407 | 50374379 |
Hyponatraemia | 45.30 | 9.74 | 630 | 220708 | 95509 | 50288277 |
Wrong patient received product | 45.27 | 9.74 | 46 | 221292 | 1654 | 50382132 |
Malignant neoplasm progression | 44.38 | 9.74 | 151 | 221187 | 67973 | 50315813 |
Myelosuppression | 44.36 | 9.74 | 4 | 221334 | 13513 | 50370273 |
Rheumatoid nodule | 43.94 | 9.74 | 3 | 221335 | 12732 | 50371054 |
Thinking abnormal | 43.12 | 9.74 | 115 | 221223 | 9452 | 50374334 |
Renal impairment | 42.60 | 9.74 | 178 | 221160 | 75483 | 50308303 |
Neutropenic sepsis | 41.88 | 9.74 | 6 | 221332 | 14141 | 50369645 |
Mania | 41.15 | 9.74 | 123 | 221215 | 10793 | 50372993 |
Neutropenia | 41.08 | 9.74 | 431 | 220907 | 147534 | 50236252 |
Mobility decreased | 40.85 | 9.74 | 195 | 221143 | 79753 | 50304033 |
Mental disorder | 40.44 | 9.74 | 197 | 221141 | 21794 | 50361992 |
Delirium | 40.42 | 9.74 | 296 | 221042 | 37896 | 50345890 |
Respiratory depression | 40.34 | 9.74 | 130 | 221208 | 11880 | 50371906 |
Bradypnoea | 40.24 | 9.74 | 58 | 221280 | 3016 | 50380770 |
Psychomotor hyperactivity | 40.11 | 9.74 | 110 | 221228 | 9191 | 50374595 |
Anger | 39.28 | 9.74 | 124 | 221214 | 11209 | 50372577 |
Hallucinations, mixed | 39.21 | 9.74 | 67 | 221271 | 4036 | 50379750 |
Live birth | 38.31 | 9.74 | 12 | 221326 | 16396 | 50367390 |
Alcohol poisoning | 37.88 | 9.74 | 43 | 221295 | 1757 | 50382029 |
Sepsis | 37.79 | 9.74 | 385 | 220953 | 132540 | 50251246 |
Mucosal inflammation | 37.66 | 9.74 | 74 | 221264 | 40068 | 50343718 |
Hyperhidrosis | 37.38 | 9.74 | 574 | 220764 | 88852 | 50294934 |
Nightmare | 37.01 | 9.74 | 154 | 221184 | 15932 | 50367854 |
Product complaint | 36.62 | 9.74 | 122 | 221216 | 11344 | 50372442 |
Premature delivery | 36.36 | 9.74 | 30 | 221308 | 23633 | 50360153 |
Drug interaction | 36.01 | 9.74 | 1135 | 220203 | 198486 | 50185300 |
Cytomegalovirus infection | 35.55 | 9.74 | 17 | 221321 | 17945 | 50365841 |
Red blood cell sedimentation rate increased | 35.36 | 9.74 | 46 | 221292 | 29370 | 50354416 |
Substance use disorder | 35.24 | 9.74 | 14 | 221324 | 84 | 50383702 |
Chemical submission | 35.14 | 9.74 | 17 | 221321 | 173 | 50383613 |
Blood pressure diastolic decreased | 34.59 | 9.74 | 15 | 221323 | 16766 | 50367020 |
Compartment syndrome | 34.53 | 9.74 | 43 | 221295 | 1939 | 50381847 |
Bone erosion | 34.50 | 9.74 | 5 | 221333 | 11682 | 50372104 |
Emotional distress | 34.36 | 9.74 | 229 | 221109 | 28434 | 50355352 |
Neutrophil count decreased | 34.25 | 9.74 | 96 | 221242 | 45930 | 50337856 |
Intentional product use issue | 34.04 | 9.74 | 197 | 221141 | 76721 | 50307065 |
Serotonin syndrome | 33.68 | 9.74 | 204 | 221134 | 24509 | 50359277 |
Head injury | 33.20 | 9.74 | 199 | 221139 | 23821 | 50359965 |
Dysphoria | 33.17 | 9.74 | 68 | 221270 | 4706 | 50379080 |
Hallucination | 32.71 | 9.74 | 330 | 221008 | 46327 | 50337459 |
Therapy non-responder | 32.62 | 9.74 | 114 | 221224 | 50908 | 50332878 |
Housebound | 32.35 | 9.74 | 17 | 221321 | 209 | 50383577 |
Renal papillary necrosis | 32 | 9.74 | 17 | 221321 | 214 | 50383572 |
Dysarthria | 31.97 | 9.74 | 276 | 221062 | 37127 | 50346659 |
Road traffic accident | 31.92 | 9.74 | 199 | 221139 | 24153 | 50359633 |
Impaired driving ability | 31.86 | 9.74 | 60 | 221278 | 3901 | 50379885 |
Pancytopenia | 31.68 | 9.74 | 226 | 221112 | 83804 | 50299982 |
Cholecystitis chronic | 30.99 | 9.74 | 103 | 221235 | 9566 | 50374220 |
Immobilisation prolonged | 30.92 | 9.74 | 13 | 221325 | 92 | 50383694 |
Arthritis | 30.89 | 9.74 | 237 | 221101 | 86484 | 50297302 |
Persistent genital arousal disorder | 30.61 | 9.74 | 17 | 221321 | 235 | 50383551 |
Adverse drug reaction | 30.41 | 9.74 | 131 | 221207 | 55091 | 50328695 |
Adjustment disorder with mixed anxiety and depressed mood | 29.93 | 9.74 | 12 | 221326 | 74 | 50383712 |
Obsessive-compulsive disorder | 29.91 | 9.74 | 53 | 221285 | 3287 | 50380499 |
Skin ulcer | 29.88 | 9.74 | 69 | 221269 | 35249 | 50348537 |
Speech disorder | 29.70 | 9.74 | 261 | 221077 | 35287 | 50348499 |
Medication error | 29.61 | 9.74 | 264 | 221074 | 35840 | 50347946 |
Sedation | 29.45 | 9.74 | 232 | 221106 | 30378 | 50353408 |
Drug detoxification | 29.42 | 9.74 | 14 | 221324 | 137 | 50383649 |
Hallucination, visual | 29.39 | 9.74 | 147 | 221191 | 16435 | 50367351 |
Accidental death | 29.06 | 9.74 | 37 | 221301 | 1707 | 50382079 |
Fear | 28.69 | 9.74 | 133 | 221205 | 14416 | 50369370 |
Sluggishness | 28.50 | 9.74 | 61 | 221277 | 4352 | 50379434 |
Multiple injuries | 28.46 | 9.74 | 36 | 221302 | 1650 | 50382136 |
Electrocardiogram QT prolonged | 28.18 | 9.74 | 349 | 220989 | 51537 | 50332249 |
Psoriatic arthropathy | 28.14 | 9.74 | 108 | 221230 | 46924 | 50336862 |
Blood pressure systolic increased | 27.84 | 9.74 | 72 | 221266 | 35377 | 50348409 |
Psychomotor retardation | 27.77 | 9.74 | 52 | 221286 | 3366 | 50380420 |
Dyspnoea | 27.38 | 9.74 | 2044 | 219294 | 545564 | 49838222 |
Femur fracture | 27.24 | 9.74 | 79 | 221259 | 37385 | 50346401 |
Fatigue | 27.12 | 9.74 | 2697 | 218641 | 704904 | 49678882 |
Suspected counterfeit product | 26.95 | 9.74 | 17 | 221321 | 301 | 50383485 |
Drug tolerance decreased | 26.85 | 9.74 | 4 | 221334 | 9156 | 50374630 |
Panic disorder | 26.63 | 9.74 | 41 | 221297 | 2262 | 50381524 |
Pruritus | 26.61 | 9.74 | 993 | 220345 | 282575 | 50101211 |
Bipolar I disorder | 26.56 | 9.74 | 33 | 221305 | 1485 | 50382301 |
Wheezing | 26.35 | 9.74 | 161 | 221177 | 61886 | 50321900 |
Device expulsion | 26.29 | 9.74 | 54 | 221284 | 28768 | 50355018 |
Suicidal behaviour | 26.22 | 9.74 | 41 | 221297 | 2293 | 50381493 |
Extrapyramidal disorder | 25.77 | 9.74 | 111 | 221227 | 11659 | 50372127 |
Bradycardia | 25.58 | 9.74 | 410 | 220928 | 64016 | 50319770 |
COVID-19 | 25.51 | 9.74 | 111 | 221227 | 46551 | 50337235 |
Blood pressure diastolic abnormal | 25.43 | 9.74 | 5 | 221333 | 9356 | 50374430 |
Hypotension | 25.12 | 9.74 | 1265 | 220073 | 234204 | 50149582 |
Inflammation | 25.05 | 9.74 | 146 | 221192 | 56766 | 50327020 |
Feeling of despair | 24.86 | 9.74 | 37 | 221301 | 1981 | 50381805 |
Poverty of speech | 24.34 | 9.74 | 16 | 221322 | 305 | 50383481 |
Post-traumatic stress disorder | 23.89 | 9.74 | 56 | 221282 | 4247 | 50379539 |
Respiratory acidosis | 23.75 | 9.74 | 69 | 221269 | 5959 | 50377827 |
Hyponatraemic encephalopathy | 23.65 | 9.74 | 14 | 221324 | 220 | 50383566 |
Anaphylactic reaction | 23.62 | 9.74 | 139 | 221199 | 53916 | 50329870 |
Cholestasis | 23.61 | 9.74 | 191 | 221147 | 25210 | 50358576 |
Injury | 23.59 | 9.74 | 322 | 221016 | 48603 | 50335183 |
Stress | 23.52 | 9.74 | 348 | 220990 | 53445 | 50330341 |
Injection site erythema | 23.42 | 9.74 | 212 | 221126 | 74724 | 50309062 |
Hypersomnia | 23.20 | 9.74 | 130 | 221208 | 15184 | 50368602 |
Muscle spasms | 23.18 | 9.74 | 716 | 220622 | 124837 | 50258949 |
Bronchiectasis | 23.17 | 9.74 | 8 | 221330 | 10275 | 50373511 |
Urticaria | 22.77 | 9.74 | 414 | 220924 | 129147 | 50254639 |
Obstructive airways disorder | 22.65 | 9.74 | 21 | 221317 | 15631 | 50368155 |
Bipolar disorder | 22.57 | 9.74 | 73 | 221265 | 6684 | 50377102 |
Pregnancy | 22.52 | 9.74 | 61 | 221277 | 29516 | 50354270 |
Transplant rejection | 22.48 | 9.74 | 7 | 221331 | 9602 | 50374184 |
Blood creatinine increased | 22.29 | 9.74 | 219 | 221119 | 75941 | 50307845 |
Blood pressure fluctuation | 22.25 | 9.74 | 81 | 221257 | 35742 | 50348044 |
Anticholinergic syndrome | 22.24 | 9.74 | 33 | 221305 | 1762 | 50382024 |
Seizure | 22.23 | 9.74 | 674 | 220664 | 117200 | 50266586 |
Benzodiazepine drug level abnormal | 22.18 | 9.74 | 5 | 221333 | 0 | 50383786 |
Inadequate analgesia | 22.15 | 9.74 | 40 | 221298 | 2518 | 50381268 |
Foot deformity | 22.12 | 9.74 | 31 | 221307 | 19179 | 50364607 |
Apathy | 22.08 | 9.74 | 78 | 221260 | 7470 | 50376316 |
Necrosis ischaemic | 21.97 | 9.74 | 22 | 221316 | 777 | 50383009 |
Tonic clonic movements | 21.81 | 9.74 | 27 | 221311 | 1210 | 50382576 |
Herpes zoster | 21.80 | 9.74 | 201 | 221137 | 70585 | 50313201 |
Grip strength decreased | 21.75 | 9.74 | 13 | 221325 | 12108 | 50371678 |
Liver function test increased | 21.68 | 9.74 | 50 | 221288 | 25556 | 50358230 |
Drug withdrawal syndrome neonatal | 21.60 | 9.74 | 33 | 221305 | 1808 | 50381978 |
Affect lability | 21.38 | 9.74 | 87 | 221251 | 8911 | 50374875 |
Hallucination, gustatory | 21.37 | 9.74 | 9 | 221329 | 64 | 50383722 |
Cardiac failure | 21.28 | 9.74 | 221 | 221117 | 75819 | 50307967 |
Multiple sclerosis | 21.21 | 9.74 | 158 | 221180 | 20335 | 50363451 |
Acquired amegakaryocytic thrombocytopenia | 21.16 | 9.74 | 6 | 221332 | 9 | 50383777 |
Leukopenia | 21.12 | 9.74 | 191 | 221147 | 67337 | 50316449 |
Restlessness | 21.12 | 9.74 | 185 | 221153 | 24988 | 50358798 |
Pneumocystis jirovecii pneumonia | 20.83 | 9.74 | 20 | 221318 | 14643 | 50369143 |
Self-injurious ideation | 20.78 | 9.74 | 36 | 221302 | 2193 | 50381593 |
Asthenia | 20.74 | 9.74 | 1642 | 219696 | 317400 | 50066386 |
Toxicologic test abnormal | 20.62 | 9.74 | 19 | 221319 | 604 | 50383182 |
Rhabdomyolysis | 20.54 | 9.74 | 261 | 221077 | 38766 | 50345020 |
Cellulitis | 20.54 | 9.74 | 204 | 221134 | 70594 | 50313192 |
Multiple sclerosis relapse | 20.40 | 9.74 | 282 | 221056 | 42682 | 50341104 |
Hepatic function abnormal | 20.23 | 9.74 | 74 | 221264 | 32607 | 50351179 |
Injection site swelling | 20.12 | 9.74 | 104 | 221234 | 41669 | 50342117 |
Somnambulism | 20.02 | 9.74 | 57 | 221281 | 4867 | 50378919 |
Electrocardiogram QRS complex prolonged | 19.94 | 9.74 | 60 | 221278 | 5284 | 50378502 |
Face injury | 19.93 | 9.74 | 40 | 221298 | 2726 | 50381060 |
Neurotoxicity | 19.92 | 9.74 | 21 | 221317 | 14719 | 50369067 |
Drug withdrawal convulsions | 19.90 | 9.74 | 27 | 221311 | 1326 | 50382460 |
Metastases to liver | 19.79 | 9.74 | 36 | 221302 | 20068 | 50363718 |
Mood altered | 19.73 | 9.74 | 109 | 221229 | 12664 | 50371122 |
Logorrhoea | 19.69 | 9.74 | 36 | 221302 | 2288 | 50381498 |
Alcohol use | 19.63 | 9.74 | 33 | 221305 | 1962 | 50381824 |
Platelet count decreased | 19.59 | 9.74 | 316 | 221022 | 100410 | 50283376 |
Wrong patient | 19.56 | 9.74 | 9 | 221329 | 81 | 50383705 |
Asthma | 19.53 | 9.74 | 274 | 221064 | 89063 | 50294723 |
Basal cell carcinoma | 19.46 | 9.74 | 46 | 221292 | 23310 | 50360476 |
Panic reaction | 19.33 | 9.74 | 46 | 221292 | 3523 | 50380263 |
Drug eruption | 19.27 | 9.74 | 47 | 221291 | 23559 | 50360227 |
Parkinsonism | 19.04 | 9.74 | 83 | 221255 | 8764 | 50375022 |
Abortion spontaneous | 19.01 | 9.74 | 106 | 221232 | 41666 | 50342120 |
Tarsal tunnel syndrome | 18.94 | 9.74 | 17 | 221321 | 522 | 50383264 |
Gun shot wound | 18.92 | 9.74 | 9 | 221329 | 88 | 50383698 |
Body temperature increased | 18.73 | 9.74 | 72 | 221266 | 31269 | 50352517 |
Thermal burn | 18.68 | 9.74 | 55 | 221283 | 4786 | 50379000 |
Hypochloraemia | 18.59 | 9.74 | 29 | 221309 | 1618 | 50382168 |
Feeling jittery | 18.43 | 9.74 | 97 | 221241 | 11063 | 50372723 |
Mental status changes | 18.43 | 9.74 | 241 | 221097 | 36031 | 50347755 |
Cutaneous T-cell dyscrasia | 18.41 | 9.74 | 8 | 221330 | 62 | 50383724 |
Blood lactic acid | 18.40 | 9.74 | 9 | 221329 | 94 | 50383692 |
Blood bilirubin increased | 18.26 | 9.74 | 75 | 221263 | 31963 | 50351823 |
Inappropriate antidiuretic hormone secretion | 18.23 | 9.74 | 109 | 221229 | 13034 | 50370752 |
Depressed mood | 18.11 | 9.74 | 228 | 221110 | 33795 | 50349991 |
Cyanosis | 18.01 | 9.74 | 121 | 221217 | 15063 | 50368723 |
Initial insomnia | 17.76 | 9.74 | 56 | 221282 | 5059 | 50378727 |
Partner stress | 17.67 | 9.74 | 13 | 221325 | 299 | 50383487 |
Tension | 17.63 | 9.74 | 38 | 221300 | 2724 | 50381062 |
Substance dependence | 17.52 | 9.74 | 11 | 221327 | 193 | 50383593 |
Major depression | 17.51 | 9.74 | 68 | 221270 | 6816 | 50376970 |
Ulcer | 17.46 | 9.74 | 39 | 221299 | 20161 | 50363625 |
Vision blurred | 17.41 | 9.74 | 459 | 220879 | 78188 | 50305598 |
Graft versus host disease | 17.38 | 9.74 | 3 | 221335 | 6163 | 50377623 |
Aplastic anaemia | 17.34 | 9.74 | 6 | 221332 | 7697 | 50376089 |
Dermatitis allergic | 17.33 | 9.74 | 18 | 221320 | 12702 | 50371084 |
Lupus-like syndrome | 17.28 | 9.74 | 10 | 221328 | 9481 | 50374305 |
Disease progression | 17.26 | 9.74 | 305 | 221033 | 95561 | 50288225 |
Chronic obstructive pulmonary disease | 17.24 | 9.74 | 329 | 221009 | 53106 | 50330680 |
Incoherent | 17.23 | 9.74 | 49 | 221289 | 4181 | 50379605 |
Diarrhoea | 17.17 | 9.74 | 2284 | 219054 | 586192 | 49797594 |
Cardiogenic shock | 17.14 | 9.74 | 122 | 221216 | 15477 | 50368309 |
Stupor | 17.10 | 9.74 | 44 | 221294 | 3539 | 50380247 |
Drug screen negative | 17.00 | 9.74 | 12 | 221326 | 258 | 50383528 |
Generalised tonic-clonic seizure | 16.98 | 9.74 | 183 | 221155 | 26127 | 50357659 |
Torsade de pointes | 16.96 | 9.74 | 99 | 221239 | 11736 | 50372050 |
Purging | 16.96 | 9.74 | 7 | 221331 | 47 | 50383739 |
Productive cough | 16.94 | 9.74 | 148 | 221190 | 52546 | 50331240 |
Morbid thoughts | 16.92 | 9.74 | 16 | 221322 | 526 | 50383260 |
Therapeutic response decreased | 16.85 | 9.74 | 129 | 221209 | 47102 | 50336684 |
Sarcomatoid carcinoma | 16.69 | 9.74 | 6 | 221332 | 26 | 50383760 |
Product substitution issue | 16.66 | 9.74 | 112 | 221226 | 13945 | 50369841 |
Mental disability | 16.66 | 9.74 | 8 | 221330 | 80 | 50383706 |
Burn oesophageal | 16.63 | 9.74 | 10 | 221328 | 162 | 50383624 |
Formication | 16.61 | 9.74 | 44 | 221294 | 3602 | 50380184 |
Death of relative | 16.58 | 9.74 | 11 | 221327 | 213 | 50383573 |
Neuroleptic malignant syndrome | 16.54 | 9.74 | 94 | 221244 | 11036 | 50372750 |
Drug-induced liver injury | 16.50 | 9.74 | 65 | 221273 | 28030 | 50355756 |
Septic shock | 16.48 | 9.74 | 165 | 221173 | 57010 | 50326776 |
Body temperature decreased | 16.46 | 9.74 | 29 | 221309 | 16366 | 50367420 |
Disinhibition | 16.45 | 9.74 | 19 | 221319 | 791 | 50382995 |
Tubulointerstitial nephritis and uveitis syndrome | 16.41 | 9.74 | 10 | 221328 | 166 | 50383620 |
Blood pressure diastolic increased | 16.41 | 9.74 | 6 | 221332 | 7437 | 50376349 |
Substance use | 16.34 | 9.74 | 13 | 221325 | 337 | 50383449 |
Developmental delay | 16.33 | 9.74 | 24 | 221314 | 1270 | 50382516 |
Tumour lysis syndrome | 16.33 | 9.74 | 6 | 221332 | 7415 | 50376371 |
Alcoholism | 16.21 | 9.74 | 27 | 221311 | 1593 | 50382193 |
Dysuria | 16.03 | 9.74 | 193 | 221145 | 28311 | 50355475 |
Hyperreflexia | 15.94 | 9.74 | 54 | 221284 | 5064 | 50378722 |
Electrocardiogram QRS complex shortened | 15.87 | 9.74 | 14 | 221324 | 420 | 50383366 |
Haemophagocytic lymphohistiocytosis | 15.86 | 9.74 | 9 | 221329 | 8624 | 50375162 |
Ataxia | 15.84 | 9.74 | 109 | 221229 | 13677 | 50370109 |
Anaemia | 15.83 | 9.74 | 923 | 220415 | 251533 | 50132253 |
Pain in extremity | 15.81 | 9.74 | 1005 | 220333 | 271860 | 50111926 |
Blood pressure systolic abnormal | 15.70 | 9.74 | 7 | 221331 | 7699 | 50376087 |
Osteonecrosis of jaw | 15.65 | 9.74 | 81 | 221257 | 32445 | 50351341 |
Alkalosis hypochloraemic | 15.62 | 9.74 | 9 | 221329 | 134 | 50383652 |
Cardiac valve disease | 15.56 | 9.74 | 44 | 221294 | 3742 | 50380044 |
Delusion | 15.53 | 9.74 | 89 | 221249 | 10480 | 50373306 |
Cardio-respiratory arrest neonatal | 15.52 | 9.74 | 4 | 221334 | 3 | 50383783 |
Tendonitis | 15.49 | 9.74 | 31 | 221307 | 16674 | 50367112 |
Liver injury | 15.47 | 9.74 | 56 | 221282 | 24750 | 50359036 |
Diffuse large B-cell lymphoma | 15.43 | 9.74 | 3 | 221335 | 5659 | 50378127 |
Bundle branch block right | 15.35 | 9.74 | 50 | 221288 | 4595 | 50379191 |
Skin necrosis | 15.23 | 9.74 | 15 | 221323 | 10852 | 50372934 |
Slow speech | 15.07 | 9.74 | 23 | 221315 | 1259 | 50382527 |
Multiple organ dysfunction syndrome | 15.04 | 9.74 | 144 | 221194 | 50193 | 50333593 |
Nodular rash | 15.01 | 9.74 | 10 | 221328 | 195 | 50383591 |
Unresponsive to stimuli | 14.98 | 9.74 | 202 | 221136 | 30407 | 50353379 |
Gambling disorder | 14.86 | 9.74 | 22 | 221316 | 1172 | 50382614 |
Obsessive-compulsive personality disorder | 14.85 | 9.74 | 5 | 221333 | 17 | 50383769 |
Dysgeusia | 14.82 | 9.74 | 246 | 221092 | 38670 | 50345116 |
Pneumonia streptococcal | 14.76 | 9.74 | 26 | 221312 | 1605 | 50382181 |
Theft | 14.75 | 9.74 | 7 | 221331 | 68 | 50383718 |
Migraine | 14.61 | 9.74 | 432 | 220906 | 74848 | 50308938 |
Coma scale | 14.57 | 9.74 | 6 | 221332 | 40 | 50383746 |
Apraxia | 14.46 | 9.74 | 25 | 221313 | 1520 | 50382266 |
Therapeutic response unexpected | 14.43 | 9.74 | 119 | 221219 | 15796 | 50367990 |
Tenosynovitis | 14.34 | 9.74 | 15 | 221323 | 10550 | 50373236 |
Faecal vomiting | 14.26 | 9.74 | 15 | 221323 | 562 | 50383224 |
Neonatal behavioural syndrome | 14.21 | 9.74 | 6 | 221332 | 43 | 50383743 |
Waxy flexibility | 14.19 | 9.74 | 8 | 221330 | 114 | 50383672 |
Brain death | 14.14 | 9.74 | 35 | 221303 | 2748 | 50381038 |
Haemoglobin decreased | 14.12 | 9.74 | 436 | 220902 | 126780 | 50257006 |
Vascular headache | 14.09 | 9.74 | 6 | 221332 | 44 | 50383742 |
Uveitis | 14.06 | 9.74 | 12 | 221326 | 9298 | 50374488 |
Panniculitis | 14.06 | 9.74 | 10 | 221328 | 8493 | 50375293 |
Obsessive thoughts | 13.97 | 9.74 | 14 | 221324 | 495 | 50383291 |
Acute myeloid leukaemia | 13.96 | 9.74 | 28 | 221310 | 15046 | 50368740 |
Emotional disorder | 13.85 | 9.74 | 94 | 221244 | 11742 | 50372044 |
Metastases to bone | 13.78 | 9.74 | 37 | 221301 | 17958 | 50365828 |
Prothrombin level decreased | 13.76 | 9.74 | 14 | 221324 | 504 | 50383282 |
Normal newborn | 13.76 | 9.74 | 6 | 221332 | 6685 | 50377101 |
Osteoarthritis | 13.75 | 9.74 | 214 | 221124 | 68392 | 50315394 |
Ascites | 13.73 | 9.74 | 96 | 221242 | 35765 | 50348021 |
Localised infection | 13.70 | 9.74 | 61 | 221277 | 25424 | 50358362 |
Blood parathyroid hormone decreased | 13.67 | 9.74 | 7 | 221331 | 7107 | 50376679 |
Oesophageal food impaction | 13.62 | 9.74 | 9 | 221329 | 173 | 50383613 |
Adverse event | 13.59 | 9.74 | 124 | 221214 | 43639 | 50340147 |
Alanine aminotransferase increased | 13.50 | 9.74 | 289 | 221049 | 88070 | 50295716 |
Diabetic ketoacidosis | 13.50 | 9.74 | 37 | 221301 | 17835 | 50365951 |
Pleural effusion | 13.46 | 9.74 | 263 | 221075 | 81191 | 50302595 |
Injection site pain | 13.45 | 9.74 | 376 | 220962 | 110648 | 50273138 |
Wrong rate | 13.44 | 9.74 | 6 | 221332 | 50 | 50383736 |
Pre-existing condition improved | 13.35 | 9.74 | 64 | 221274 | 7033 | 50376753 |
LDL/HDL ratio increased | 13.31 | 9.74 | 3 | 221335 | 0 | 50383786 |
Maternal exposure before pregnancy | 13.24 | 9.74 | 4 | 221334 | 5593 | 50378193 |
Tardive dyskinesia | 13.23 | 9.74 | 65 | 221273 | 7214 | 50376572 |
Oropharyngeal pain | 13.22 | 9.74 | 250 | 221088 | 77551 | 50306235 |
Soliloquy | 13.19 | 9.74 | 9 | 221329 | 183 | 50383603 |
Full blood count abnormal | 13.17 | 9.74 | 55 | 221283 | 23333 | 50360453 |
Dizziness | 13.13 | 9.74 | 1718 | 219620 | 344651 | 50039135 |
Joint effusion | 13.10 | 9.74 | 23 | 221315 | 12998 | 50370788 |
Cerebral microangiopathy | 13.09 | 9.74 | 10 | 221328 | 244 | 50383542 |
Exposure via inhalation | 13.02 | 9.74 | 5 | 221333 | 27 | 50383759 |
Gallbladder disorder | 13.00 | 9.74 | 121 | 221217 | 16621 | 50367165 |
Product physical issue | 12.87 | 9.74 | 45 | 221293 | 4287 | 50379499 |
Atrioventricular septal defect | 12.84 | 9.74 | 10 | 221328 | 251 | 50383535 |
Brugada syndrome | 12.78 | 9.74 | 11 | 221327 | 319 | 50383467 |
Laryngomalacia | 12.76 | 9.74 | 6 | 221332 | 57 | 50383729 |
Premature labour | 12.74 | 9.74 | 19 | 221319 | 11457 | 50372329 |
Homicidal ideation | 12.73 | 9.74 | 25 | 221313 | 1677 | 50382109 |
Phobia | 12.73 | 9.74 | 11 | 221327 | 321 | 50383465 |
Suspiciousness | 12.73 | 9.74 | 11 | 221327 | 321 | 50383465 |
Distributive shock | 12.72 | 9.74 | 17 | 221321 | 823 | 50382963 |
Congenital central nervous system anomaly | 12.70 | 9.74 | 11 | 221327 | 322 | 50383464 |
Conversion disorder | 12.62 | 9.74 | 24 | 221314 | 1572 | 50382214 |
Oesophageal achalasia | 12.53 | 9.74 | 12 | 221326 | 401 | 50383385 |
Hyporesponsive to stimuli | 12.52 | 9.74 | 18 | 221320 | 934 | 50382852 |
Gastrointestinal haemorrhage | 12.34 | 9.74 | 236 | 221102 | 73085 | 50310701 |
Pneumoconiosis | 12.25 | 9.74 | 4 | 221334 | 12 | 50383774 |
Cutaneous lymphoma | 12.24 | 9.74 | 8 | 221330 | 151 | 50383635 |
Libido decreased | 12.20 | 9.74 | 30 | 221308 | 2346 | 50381440 |
Cardio-respiratory distress | 12.19 | 9.74 | 8 | 221330 | 152 | 50383634 |
Persecutory delusion | 12.11 | 9.74 | 30 | 221308 | 2357 | 50381429 |
Performance status decreased | 12.04 | 9.74 | 36 | 221302 | 3159 | 50380627 |
Divorced | 12.02 | 9.74 | 4 | 221334 | 13 | 50383773 |
Victim of crime | 12.00 | 9.74 | 6 | 221332 | 66 | 50383720 |
Deep vein thrombosis | 11.96 | 9.74 | 412 | 220926 | 72892 | 50310894 |
Gallbladder hypofunction | 11.83 | 9.74 | 13 | 221325 | 512 | 50383274 |
Sleep disorder due to a general medical condition | 11.76 | 9.74 | 9 | 221329 | 7362 | 50376424 |
Cognitive disorder | 11.72 | 9.74 | 264 | 221074 | 43859 | 50339927 |
Craniosynostosis | 11.71 | 9.74 | 8 | 221330 | 163 | 50383623 |
Bone density decreased | 11.66 | 9.74 | 19 | 221319 | 11056 | 50372730 |
Coagulation factor V level decreased | 11.62 | 9.74 | 10 | 221328 | 290 | 50383496 |
Musculoskeletal disorder | 11.60 | 9.74 | 38 | 221300 | 17311 | 50366475 |
Poor venous access | 11.59 | 9.74 | 17 | 221321 | 10323 | 50373463 |
Prescription drug used without a prescription | 11.56 | 9.74 | 24 | 221314 | 1676 | 50382110 |
Throat irritation | 11.55 | 9.74 | 81 | 221257 | 30158 | 50353628 |
Drug screen false positive | 11.53 | 9.74 | 16 | 221322 | 803 | 50382983 |
Prothrombin level increased | 11.46 | 9.74 | 9 | 221329 | 229 | 50383557 |
Hyperaldosteronism | 11.46 | 9.74 | 9 | 221329 | 229 | 50383557 |
Toxic epidermal necrolysis | 11.43 | 9.74 | 50 | 221288 | 20942 | 50362844 |
Paranoia | 11.41 | 9.74 | 81 | 221257 | 10267 | 50373519 |
Crime | 11.38 | 9.74 | 4 | 221334 | 16 | 50383770 |
Hepatotoxicity | 11.37 | 9.74 | 71 | 221267 | 27155 | 50356631 |
Product quality issue | 11.36 | 9.74 | 194 | 221144 | 30664 | 50353122 |
Hypercalcaemia | 11.32 | 9.74 | 58 | 221280 | 23294 | 50360492 |
Eating disorder | 11.29 | 9.74 | 110 | 221228 | 15299 | 50368487 |
Pharyngitis | 11.26 | 9.74 | 39 | 221299 | 17464 | 50366322 |
Limb fracture | 11.24 | 9.74 | 3 | 221335 | 3 | 50383783 |
Pelvic floor dysfunction | 11.24 | 9.74 | 3 | 221335 | 3 | 50383783 |
Enthesopathy | 11.20 | 9.74 | 9 | 221329 | 7184 | 50376602 |
Blastocystis infection | 11.19 | 9.74 | 4 | 221334 | 17 | 50383769 |
Tubulointerstitial nephritis | 11.11 | 9.74 | 32 | 221306 | 15179 | 50368607 |
Injection site reaction | 11.09 | 9.74 | 153 | 221185 | 49879 | 50333907 |
Balance disorder | 11.08 | 9.74 | 395 | 220943 | 70195 | 50313591 |
Creatinine renal clearance decreased | 11.06 | 9.74 | 22 | 221316 | 11859 | 50371927 |
Counterfeit product administered | 11.01 | 9.74 | 4 | 221334 | 18 | 50383768 |
Hypotonia | 10.99 | 9.74 | 67 | 221271 | 8067 | 50375719 |
Hair texture abnormal | 10.88 | 9.74 | 38 | 221300 | 3618 | 50380168 |
Clostridium difficile infection | 10.80 | 9.74 | 66 | 221272 | 25373 | 50358413 |
Liver function test abnormal | 10.78 | 9.74 | 133 | 221205 | 44206 | 50339580 |
Retrograde amnesia | 10.72 | 9.74 | 11 | 221327 | 400 | 50383386 |
Depersonalisation/derealisation disorder | 10.72 | 9.74 | 19 | 221319 | 1179 | 50382607 |
Joint stiffness | 10.71 | 9.74 | 83 | 221255 | 30225 | 50353561 |
Corneal reflex decreased | 10.67 | 9.74 | 7 | 221331 | 133 | 50383653 |
Perseveration | 10.67 | 9.74 | 9 | 221329 | 254 | 50383532 |
Akathisia | 10.63 | 9.74 | 67 | 221271 | 8162 | 50375624 |
Haemorrhage | 10.60 | 9.74 | 167 | 221171 | 53274 | 50330512 |
Dyskinesia | 10.57 | 9.74 | 176 | 221162 | 27685 | 50356101 |
Blood alcohol increased | 10.57 | 9.74 | 13 | 221325 | 579 | 50383207 |
Oligohydramnios | 10.55 | 9.74 | 6 | 221332 | 5744 | 50378042 |
Blood creatine phosphokinase increased | 10.54 | 9.74 | 168 | 221170 | 26199 | 50357587 |
Blood cholesterol increased | 10.47 | 9.74 | 174 | 221164 | 55041 | 50328745 |
Pancreatitis acute | 10.39 | 9.74 | 154 | 221184 | 23658 | 50360128 |
Beta haemolytic streptococcal infection | 10.36 | 9.74 | 24 | 221314 | 1806 | 50381980 |
Encephalopathy | 10.34 | 9.74 | 206 | 221132 | 33505 | 50350281 |
Haematochezia | 10.32 | 9.74 | 118 | 221220 | 39764 | 50344022 |
Rhinorrhoea | 10.30 | 9.74 | 161 | 221177 | 51422 | 50332364 |
Abdominal operation | 10.29 | 9.74 | 12 | 221326 | 505 | 50383281 |
Injection site pruritus | 10.29 | 9.74 | 120 | 221218 | 40291 | 50343495 |
Reduced facial expression | 10.25 | 9.74 | 22 | 221316 | 1572 | 50382214 |
Nephropathy toxic | 10.23 | 9.74 | 12 | 221326 | 8017 | 50375769 |
Injection site bruising | 10.23 | 9.74 | 107 | 221231 | 36661 | 50347125 |
Newborn persistent pulmonary hypertension | 10.23 | 9.74 | 7 | 221331 | 143 | 50383643 |
Venoocclusive liver disease | 10.16 | 9.74 | 3 | 221335 | 4258 | 50379528 |
Arthritis bacterial | 10.15 | 9.74 | 6 | 221332 | 5623 | 50378163 |
Postmortem blood drug level abnormal | 10.11 | 9.74 | 10 | 221328 | 348 | 50383438 |
Electroencephalogram abnormal | 10.10 | 9.74 | 36 | 221302 | 3463 | 50380323 |
Erythrodermic psoriasis | 10.10 | 9.74 | 16 | 221322 | 905 | 50382881 |
Purpura senile | 10.07 | 9.74 | 12 | 221326 | 517 | 50383269 |
Hyperinsulinism | 10.04 | 9.74 | 3 | 221335 | 6 | 50383780 |
Cardioplegia | 10.04 | 9.74 | 3 | 221335 | 6 | 50383780 |
Pneumonia aspiration | 10.03 | 9.74 | 191 | 221147 | 30813 | 50352973 |
Nephrosclerosis | 10.01 | 9.74 | 16 | 221322 | 912 | 50382874 |
Sensitivity to weather change | 10.00 | 9.74 | 7 | 221331 | 5994 | 50377792 |
Tuberculosis | 9.97 | 9.74 | 18 | 221320 | 10065 | 50373721 |
Lethargy | 9.95 | 9.74 | 285 | 221053 | 49147 | 50334639 |
Polyarthritis | 9.94 | 9.74 | 12 | 221326 | 7915 | 50375871 |
Gait disturbance | 9.88 | 9.74 | 773 | 220565 | 149232 | 50234554 |
Feeling of relaxation | 9.84 | 9.74 | 5 | 221333 | 57 | 50383729 |
Polydipsia | 9.76 | 9.74 | 33 | 221305 | 3091 | 50380695 |
Attention deficit hyperactivity disorder | 9.76 | 9.74 | 28 | 221310 | 2401 | 50381385 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug abuse | 7256.17 | 10.54 | 4129 | 101626 | 75754 | 29393018 |
Completed suicide | 2069.61 | 10.54 | 2046 | 103709 | 88200 | 29380572 |
Toxicity to various agents | 2015.05 | 10.54 | 2770 | 102985 | 170891 | 29297881 |
Respiratory arrest | 1809.71 | 10.54 | 1135 | 104620 | 24698 | 29444074 |
Poisoning | 1432.25 | 10.54 | 704 | 105051 | 9289 | 29459483 |
Cardio-respiratory arrest | 1048.63 | 10.54 | 1088 | 104667 | 49513 | 29419259 |
Cardiac arrest | 870.68 | 10.54 | 1286 | 104469 | 84305 | 29384467 |
Intentional product misuse | 736.85 | 10.54 | 756 | 104999 | 33905 | 29434867 |
Drug dependence | 674.26 | 10.54 | 576 | 105179 | 20405 | 29448367 |
Sopor | 655.28 | 10.54 | 436 | 105319 | 10498 | 29458274 |
Overdose | 526.58 | 10.54 | 988 | 104767 | 78831 | 29389941 |
Coma | 522.54 | 10.54 | 674 | 105081 | 38776 | 29429996 |
Suicide attempt | 509.59 | 10.54 | 619 | 105136 | 33491 | 29435281 |
Intentional overdose | 440.91 | 10.54 | 613 | 105142 | 37915 | 29430857 |
Poisoning deliberate | 349.26 | 10.54 | 231 | 105524 | 5500 | 29463272 |
Exposure via ingestion | 270.64 | 10.54 | 136 | 105619 | 1882 | 29466890 |
Prescription form tampering | 229.90 | 10.54 | 79 | 105676 | 373 | 29468399 |
Withdrawal syndrome | 224.72 | 10.54 | 235 | 105520 | 10757 | 29458015 |
Drug withdrawal syndrome | 208.33 | 10.54 | 288 | 105467 | 17696 | 29451076 |
Drug use disorder | 189.51 | 10.54 | 130 | 105625 | 3292 | 29465480 |
Somnolence | 186.66 | 10.54 | 747 | 105008 | 93208 | 29375564 |
Accidental overdose | 186.43 | 10.54 | 270 | 105485 | 17323 | 29451449 |
Substance abuse | 177.54 | 10.54 | 166 | 105589 | 6621 | 29462151 |
Intentional self-injury | 176.00 | 10.54 | 220 | 105535 | 12241 | 29456531 |
Off label use | 158.04 | 10.54 | 550 | 105205 | 300250 | 29168522 |
Miosis | 147.44 | 10.54 | 162 | 105593 | 7847 | 29460925 |
Drug abuser | 145.66 | 10.54 | 116 | 105639 | 3711 | 29465061 |
Anxiety | 138.85 | 10.54 | 639 | 105116 | 84726 | 29384046 |
Death | 136.68 | 10.54 | 1841 | 103914 | 340243 | 29128529 |
Febrile neutropenia | 127.43 | 10.54 | 128 | 105627 | 112112 | 29356660 |
Respiratory depression | 125.37 | 10.54 | 195 | 105560 | 13328 | 29455444 |
Bradypnoea | 124.08 | 10.54 | 87 | 105668 | 2284 | 29466488 |
Pyrexia | 122.48 | 10.54 | 571 | 105184 | 287051 | 29181721 |
Suicidal ideation | 116.98 | 10.54 | 330 | 105425 | 34386 | 29434386 |
Agitation | 101.01 | 10.54 | 407 | 105348 | 50897 | 29417875 |
Drug screen positive | 99.47 | 10.54 | 93 | 105662 | 3708 | 29465064 |
Depression | 97.96 | 10.54 | 579 | 105176 | 84568 | 29384204 |
Drug ineffective | 96.80 | 10.54 | 833 | 104922 | 362337 | 29106435 |
Pneumonia | 84.50 | 10.54 | 736 | 105019 | 319436 | 29149336 |
Bradyphrenia | 82.39 | 10.54 | 88 | 105667 | 4126 | 29464646 |
Insomnia | 80.84 | 10.54 | 569 | 105186 | 88192 | 29380580 |
Depressed level of consciousness | 72.63 | 10.54 | 293 | 105462 | 36649 | 29432123 |
Sepsis | 71.90 | 10.54 | 265 | 105490 | 142417 | 29326355 |
Accidental death | 71.77 | 10.54 | 60 | 105695 | 2058 | 29466714 |
Neutropenia | 69.43 | 10.54 | 240 | 105515 | 131471 | 29337301 |
Counterfeit product administered | 67.96 | 10.54 | 25 | 105730 | 149 | 29468623 |
Product use in unapproved indication | 64.98 | 10.54 | 133 | 105622 | 86742 | 29382030 |
Treatment failure | 63.88 | 10.54 | 26 | 105729 | 36913 | 29431859 |
Panic attack | 63.56 | 10.54 | 110 | 105645 | 8216 | 29460556 |
Renal impairment | 62.99 | 10.54 | 122 | 105633 | 81211 | 29387561 |
Unresponsive to stimuli | 61.64 | 10.54 | 214 | 105541 | 24912 | 29443860 |
Cough | 60.83 | 10.54 | 240 | 105515 | 126487 | 29342285 |
Infection | 59.54 | 10.54 | 115 | 105640 | 76636 | 29392136 |
Asphyxia | 58.38 | 10.54 | 83 | 105672 | 5232 | 29463540 |
C-reactive protein increased | 56.74 | 10.54 | 45 | 105710 | 44218 | 29424554 |
Aggression | 56.18 | 10.54 | 264 | 105491 | 35277 | 29433495 |
Drug resistance | 55.73 | 10.54 | 6 | 105749 | 21534 | 29447238 |
Drug tolerance | 55.04 | 10.54 | 52 | 105703 | 2101 | 29466671 |
Cytomegalovirus infection | 54.04 | 10.54 | 9 | 105746 | 23206 | 29445566 |
Irritability | 53.76 | 10.54 | 188 | 105567 | 21964 | 29446808 |
Infusion related reaction | 53.32 | 10.54 | 47 | 105708 | 43839 | 29424933 |
Amnesia | 52.24 | 10.54 | 189 | 105566 | 22454 | 29446318 |
Toxicologic test abnormal | 51.86 | 10.54 | 29 | 105726 | 504 | 29468268 |
Pulmonary oedema | 51.29 | 10.54 | 294 | 105461 | 42441 | 29426331 |
Product counterfeit | 50.46 | 10.54 | 19 | 105736 | 122 | 29468650 |
Lower respiratory tract infection | 50.34 | 10.54 | 16 | 105739 | 26486 | 29442286 |
Platelet count decreased | 49.72 | 10.54 | 199 | 105556 | 104473 | 29364299 |
Anaemia | 49.34 | 10.54 | 470 | 105285 | 200481 | 29268291 |
Postmortem blood drug level abnormal | 48.95 | 10.54 | 23 | 105732 | 272 | 29468500 |
Diarrhoea | 48.86 | 10.54 | 867 | 104888 | 331831 | 29136941 |
Alcohol interaction | 46.87 | 10.54 | 53 | 105702 | 2650 | 29466122 |
Abnormal behaviour | 45.10 | 10.54 | 183 | 105572 | 22944 | 29445828 |
Rash | 44.47 | 10.54 | 449 | 105306 | 189370 | 29279402 |
Hepatic function abnormal | 44.23 | 10.54 | 45 | 105710 | 39214 | 29429558 |
Self-medication | 43.92 | 10.54 | 46 | 105709 | 2108 | 29466664 |
Narcotic bowel syndrome | 39.82 | 10.54 | 16 | 105739 | 125 | 29468647 |
Acute kidney injury | 39.29 | 10.54 | 690 | 105065 | 264577 | 29204195 |
Tremor | 39.27 | 10.54 | 419 | 105336 | 73119 | 29395653 |
Mucosal inflammation | 38.18 | 10.54 | 34 | 105721 | 31561 | 29437211 |
Disorientation | 37.36 | 10.54 | 206 | 105549 | 29309 | 29439463 |
Abulia | 37.08 | 10.54 | 23 | 105732 | 488 | 29468284 |
Pulmonary congestion | 36.87 | 10.54 | 113 | 105642 | 12323 | 29456449 |
Cardiac failure | 36.85 | 10.54 | 152 | 105603 | 79135 | 29389637 |
Pancytopenia | 36.47 | 10.54 | 163 | 105592 | 83005 | 29385767 |
Blood creatinine increased | 36.00 | 10.54 | 169 | 105586 | 84933 | 29383839 |
Neutrophil count decreased | 34.89 | 10.54 | 64 | 105691 | 43503 | 29425269 |
Interstitial lung disease | 34.72 | 10.54 | 99 | 105656 | 57619 | 29411153 |
Loss of consciousness | 34.58 | 10.54 | 411 | 105344 | 73645 | 29395127 |
COVID-19 | 34.44 | 10.54 | 47 | 105708 | 35967 | 29432805 |
Anger | 34.22 | 10.54 | 101 | 105654 | 10789 | 29457983 |
Dyspnoea | 34.10 | 10.54 | 899 | 104856 | 325833 | 29142939 |
Respiratory rate decreased | 33.49 | 10.54 | 38 | 105717 | 1907 | 29466865 |
Condition aggravated | 33.02 | 10.54 | 349 | 105406 | 145946 | 29322826 |
Joint swelling | 32.98 | 10.54 | 81 | 105674 | 49549 | 29419223 |
Paramnesia | 32.64 | 10.54 | 8 | 105747 | 6 | 29468766 |
Brain oedema | 32.54 | 10.54 | 107 | 105648 | 12113 | 29456659 |
White blood cell count decreased | 32.14 | 10.54 | 171 | 105584 | 83191 | 29385581 |
Arthralgia | 31.94 | 10.54 | 332 | 105423 | 139285 | 29329487 |
Road traffic accident | 31.83 | 10.54 | 125 | 105630 | 15436 | 29453336 |
Haemoglobin decreased | 31.22 | 10.54 | 243 | 105512 | 108132 | 29360640 |
Nervousness | 31.01 | 10.54 | 100 | 105655 | 11206 | 29457566 |
Altered state of consciousness | 30.88 | 10.54 | 147 | 105608 | 19742 | 29449030 |
Suspected suicide | 30.54 | 10.54 | 53 | 105702 | 3967 | 29464805 |
Feeling abnormal | 30.37 | 10.54 | 313 | 105442 | 54132 | 29414640 |
Dependence | 30.36 | 10.54 | 27 | 105728 | 1008 | 29467764 |
Pneumocystis jirovecii pneumonia | 30.35 | 10.54 | 11 | 105744 | 16768 | 29452004 |
Bone marrow failure | 30.31 | 10.54 | 32 | 105723 | 27417 | 29441355 |
Respiratory failure | 30.26 | 10.54 | 213 | 105542 | 96918 | 29371854 |
Alcohol abuse | 30.18 | 10.54 | 55 | 105700 | 4278 | 29464494 |
Myelosuppression | 30.16 | 10.54 | 4 | 105751 | 12223 | 29456549 |
Drug withdrawal syndrome neonatal | 30.13 | 10.54 | 48 | 105707 | 3347 | 29465425 |
Disturbance in attention | 29.47 | 10.54 | 153 | 105602 | 21271 | 29447501 |
Analgesic drug level increased | 29.30 | 10.54 | 21 | 105734 | 571 | 29468201 |
Drug detoxification | 29.18 | 10.54 | 14 | 105741 | 174 | 29468598 |
Gastrointestinal haemorrhage | 29.09 | 10.54 | 166 | 105589 | 79367 | 29389405 |
Drug intolerance | 29.08 | 10.54 | 83 | 105672 | 48296 | 29420476 |
Disease progression | 28.89 | 10.54 | 173 | 105582 | 81743 | 29387029 |
Homicide | 28.81 | 10.54 | 25 | 105730 | 903 | 29467869 |
Alcohol use | 28.79 | 10.54 | 45 | 105710 | 3087 | 29465685 |
Therapeutic product effect incomplete | 28.66 | 10.54 | 61 | 105694 | 39244 | 29429528 |
Bladder dilatation | 28.59 | 10.54 | 29 | 105726 | 1279 | 29467493 |
Neutropenic sepsis | 28.54 | 10.54 | 4 | 105751 | 11723 | 29457049 |
General physical health deterioration | 28.52 | 10.54 | 233 | 105522 | 102624 | 29366148 |
Renal failure | 27.95 | 10.54 | 280 | 105475 | 118319 | 29350453 |
Rheumatoid arthritis | 27.78 | 10.54 | 45 | 105710 | 32107 | 29436665 |
Psychomotor hyperactivity | 27.57 | 10.54 | 78 | 105677 | 8135 | 29460637 |
Angioedema | 27.27 | 10.54 | 45 | 105710 | 31870 | 29436902 |
Cerebral haemorrhage | 27.14 | 10.54 | 44 | 105711 | 31382 | 29437390 |
Bradykinesia | 26.91 | 10.54 | 46 | 105709 | 3401 | 29465371 |
Hyperthermia | 26.40 | 10.54 | 84 | 105671 | 9346 | 29459426 |
Distributive shock | 25.58 | 10.54 | 24 | 105731 | 961 | 29467811 |
Lactic acidosis | 25.52 | 10.54 | 43 | 105712 | 30204 | 29438568 |
Erythema | 25.45 | 10.54 | 162 | 105593 | 75444 | 29393328 |
Panic disorder | 25.32 | 10.54 | 26 | 105729 | 1164 | 29467608 |
Thinking abnormal | 25.19 | 10.54 | 57 | 105698 | 5179 | 29463593 |
Hospitalisation | 24.73 | 10.54 | 83 | 105672 | 45905 | 29422867 |
Blood pressure fluctuation | 24.53 | 10.54 | 21 | 105734 | 19873 | 29448899 |
Malignant neoplasm progression | 24.48 | 10.54 | 159 | 105596 | 73700 | 29395072 |
Contraindicated product administered | 24.13 | 10.54 | 18 | 105737 | 18248 | 29450524 |
Withdrawal catatonia | 24.06 | 10.54 | 10 | 105745 | 86 | 29468686 |
Alanine aminotransferase increased | 23.88 | 10.54 | 152 | 105603 | 70792 | 29397980 |
Exposure during pregnancy | 23.77 | 10.54 | 76 | 105679 | 8478 | 29460294 |
Gun shot wound | 23.62 | 10.54 | 24 | 105731 | 1061 | 29467711 |
Hypervigilance | 23.56 | 10.54 | 11 | 105744 | 128 | 29468644 |
Hypervolaemia | 23.55 | 10.54 | 17 | 105738 | 17528 | 29451244 |
Stomatitis | 23.55 | 10.54 | 62 | 105693 | 37051 | 29431721 |
Incorrect route of product administration | 23.10 | 10.54 | 88 | 105667 | 10713 | 29458059 |
Generalised anxiety disorder | 22.97 | 10.54 | 19 | 105736 | 642 | 29468130 |
Dysarthria | 22.95 | 10.54 | 189 | 105566 | 30722 | 29438050 |
Inadequate analgesia | 22.84 | 10.54 | 37 | 105718 | 2617 | 29466155 |
Pneumonia aspiration | 22.81 | 10.54 | 216 | 105539 | 36521 | 29432251 |
Nasopharyngitis | 22.65 | 10.54 | 123 | 105632 | 59542 | 29409230 |
Mydriasis | 22.63 | 10.54 | 60 | 105695 | 6025 | 29462747 |
Cardiac failure congestive | 22.37 | 10.54 | 171 | 105584 | 76410 | 29392362 |
Deafness neurosensory | 22.27 | 10.54 | 36 | 105719 | 2542 | 29466230 |
Atrial fibrillation | 22.23 | 10.54 | 256 | 105499 | 105390 | 29363382 |
Accident | 22.21 | 10.54 | 44 | 105711 | 3644 | 29465128 |
Drug tolerance increased | 21.95 | 10.54 | 16 | 105739 | 447 | 29468325 |
Chorea | 21.90 | 10.54 | 22 | 105733 | 959 | 29467813 |
Acute myocardial infarction | 21.79 | 10.54 | 94 | 105661 | 48344 | 29420428 |
Hyperleukocytosis | 21.71 | 10.54 | 28 | 105727 | 1607 | 29467165 |
Substance use disorder | 21.42 | 10.54 | 13 | 105742 | 265 | 29468507 |
Sedation | 21.04 | 10.54 | 120 | 105635 | 17285 | 29451487 |
Poverty of speech | 20.89 | 10.54 | 12 | 105743 | 220 | 29468552 |
Stevens-Johnson syndrome | 20.85 | 10.54 | 17 | 105738 | 16480 | 29452292 |
Bronchopulmonary aspergillosis | 20.84 | 10.54 | 9 | 105746 | 12335 | 29456437 |
Aspergillus infection | 20.79 | 10.54 | 6 | 105749 | 10575 | 29458197 |
Vestibular ischaemia | 20.65 | 10.54 | 6 | 105749 | 14 | 29468758 |
Ascites | 20.44 | 10.54 | 65 | 105690 | 36554 | 29432218 |
Oedematous pancreatitis | 20.13 | 10.54 | 15 | 105740 | 434 | 29468338 |
Anaphylactic reaction | 19.93 | 10.54 | 43 | 105712 | 27530 | 29441242 |
Major depression | 19.86 | 10.54 | 43 | 105712 | 3792 | 29464980 |
Hypersensitivity | 19.56 | 10.54 | 110 | 105645 | 52793 | 29415979 |
Drug diversion | 19.54 | 10.54 | 19 | 105736 | 796 | 29467976 |
Puncture site haematoma | 19.42 | 10.54 | 10 | 105745 | 146 | 29468626 |
Pleural effusion | 19.42 | 10.54 | 164 | 105591 | 71744 | 29397028 |
Hyperkalaemia | 19.42 | 10.54 | 134 | 105621 | 61258 | 29407514 |
Serotonin syndrome | 19.40 | 10.54 | 118 | 105637 | 17394 | 29451378 |
Pathogen resistance | 19.22 | 10.54 | 3 | 105752 | 8113 | 29460659 |
Pruritus | 19.18 | 10.54 | 298 | 105457 | 116551 | 29352221 |
Dizziness | 19.17 | 10.54 | 524 | 105231 | 189160 | 29279612 |
Haematochezia | 19.04 | 10.54 | 68 | 105687 | 36915 | 29431857 |
Urticaria | 18.96 | 10.54 | 116 | 105639 | 54544 | 29414228 |
Myocardial infarction | 18.89 | 10.54 | 279 | 105476 | 110017 | 29358755 |
Myotonia | 18.85 | 10.54 | 7 | 105748 | 43 | 29468729 |
Psoriatic arthropathy | 18.74 | 10.54 | 15 | 105740 | 14676 | 29454096 |
Heart rate decreased | 18.72 | 10.54 | 38 | 105717 | 24874 | 29443898 |
Catatonia | 18.63 | 10.54 | 46 | 105709 | 4422 | 29464350 |
Cytokine release syndrome | 18.56 | 10.54 | 12 | 105743 | 13107 | 29455665 |
Papillary muscle disorder | 18.55 | 10.54 | 4 | 105751 | 0 | 29468772 |
Neurotoxicity | 18.54 | 10.54 | 15 | 105740 | 14598 | 29454174 |
Leukopenia | 18.20 | 10.54 | 119 | 105636 | 55084 | 29413688 |
Substance abuser | 18.20 | 10.54 | 8 | 105747 | 80 | 29468692 |
Sudden death | 18.20 | 10.54 | 99 | 105656 | 14011 | 29454761 |
Haemorrhage | 18.18 | 10.54 | 91 | 105664 | 44981 | 29423791 |
Legal problem | 18.08 | 10.54 | 10 | 105745 | 170 | 29468602 |
Confusional state | 17.97 | 10.54 | 591 | 105164 | 127286 | 29341486 |
Liver disorder | 17.88 | 10.54 | 46 | 105709 | 27703 | 29441069 |
Cerebral congestion | 17.87 | 10.54 | 6 | 105749 | 26 | 29468746 |
Liver function test abnormal | 17.83 | 10.54 | 49 | 105706 | 28869 | 29439903 |
Inappropriate schedule of product administration | 17.82 | 10.54 | 90 | 105665 | 44382 | 29424390 |
Herpes zoster | 17.73 | 10.54 | 52 | 105703 | 30000 | 29438772 |
Slow speech | 17.68 | 10.54 | 19 | 105736 | 897 | 29467875 |
Pneumonitis | 17.68 | 10.54 | 47 | 105708 | 27997 | 29440775 |
Hepatotoxicity | 17.40 | 10.54 | 23 | 105732 | 17844 | 29450928 |
Tachyphylaxis | 17.38 | 10.54 | 8 | 105747 | 90 | 29468682 |
Thrombocytopenia | 17.33 | 10.54 | 359 | 105396 | 134464 | 29334308 |
Memory impairment | 17.27 | 10.54 | 203 | 105552 | 36267 | 29432505 |
Drug withdrawal convulsions | 17.20 | 10.54 | 21 | 105734 | 1140 | 29467632 |
Obstructive airways disorder | 17.11 | 10.54 | 9 | 105746 | 11007 | 29457765 |
Leukoencephalopathy | 17.01 | 10.54 | 40 | 105715 | 3727 | 29465045 |
Gastric haemorrhage | 16.98 | 10.54 | 6 | 105749 | 9291 | 29459481 |
Blood triglycerides decreased | 16.66 | 10.54 | 7 | 105748 | 62 | 29468710 |
Lymphadenopathy | 16.54 | 10.54 | 41 | 105714 | 25008 | 29443764 |
Bacterial prostatitis | 16.47 | 10.54 | 7 | 105748 | 64 | 29468708 |
Diabetic ketoacidosis | 16.37 | 10.54 | 20 | 105735 | 16053 | 29452719 |
Foetal exposure during pregnancy | 16.30 | 10.54 | 64 | 105691 | 33803 | 29434969 |
Product substitution | 16.28 | 10.54 | 6 | 105749 | 36 | 29468736 |
Asthma | 16.27 | 10.54 | 64 | 105691 | 33785 | 29434987 |
Anamnestic reaction | 16.14 | 10.54 | 6 | 105749 | 37 | 29468735 |
Cataract | 16.09 | 10.54 | 35 | 105720 | 22343 | 29446429 |
Oedema peripheral | 16.03 | 10.54 | 267 | 105488 | 103290 | 29365482 |
Blood creatine phosphokinase | 16.01 | 10.54 | 7 | 105748 | 69 | 29468703 |
Delirium | 15.96 | 10.54 | 213 | 105542 | 39184 | 29429588 |
Bacteraemia | 15.91 | 10.54 | 21 | 105734 | 16302 | 29452470 |
Cerebral infarction | 15.82 | 10.54 | 41 | 105714 | 24634 | 29444138 |
Epistaxis | 15.79 | 10.54 | 114 | 105641 | 51590 | 29417182 |
Ventricular tachyarrhythmia | 15.74 | 10.54 | 11 | 105744 | 287 | 29468485 |
Victim of crime | 15.70 | 10.54 | 12 | 105743 | 361 | 29468411 |
Brachial plexus injury | 15.59 | 10.54 | 7 | 105748 | 74 | 29468698 |
Sexual dysfunction | 15.56 | 10.54 | 51 | 105704 | 5763 | 29463009 |
Renal tubular necrosis | 15.46 | 10.54 | 17 | 105738 | 14298 | 29454474 |
Acute myeloid leukaemia | 15.33 | 10.54 | 22 | 105733 | 16491 | 29452281 |
Wheezing | 15.26 | 10.54 | 64 | 105691 | 33176 | 29435596 |
Peripheral swelling | 15.20 | 10.54 | 150 | 105605 | 63589 | 29405183 |
Transplant rejection | 15.10 | 10.54 | 7 | 105748 | 9205 | 29459567 |
Blood pressure systolic increased | 15.10 | 10.54 | 23 | 105732 | 16822 | 29451950 |
Homicidal ideation | 15.06 | 10.54 | 30 | 105725 | 2494 | 29466278 |
Nephropathy toxic | 15.00 | 10.54 | 10 | 105745 | 10746 | 29458026 |
Speech disorder | 14.96 | 10.54 | 139 | 105616 | 23377 | 29445395 |
Tubulointerstitial nephritis | 14.95 | 10.54 | 25 | 105730 | 17618 | 29451154 |
Melaena | 14.95 | 10.54 | 59 | 105696 | 31117 | 29437655 |
Cyclothymic disorder | 14.88 | 10.54 | 7 | 105748 | 83 | 29468689 |
Drug eruption | 14.87 | 10.54 | 23 | 105732 | 16718 | 29452054 |
Intrusive thoughts | 14.86 | 10.54 | 10 | 105745 | 245 | 29468527 |
Cardio-respiratory distress | 14.73 | 10.54 | 8 | 105747 | 131 | 29468641 |
Hallucination, visual | 14.67 | 10.54 | 98 | 105657 | 14917 | 29453855 |
Anticholinergic syndrome | 14.61 | 10.54 | 17 | 105738 | 877 | 29467895 |
Thymus disorder | 14.53 | 10.54 | 4 | 105751 | 7 | 29468765 |
COVID-19 pneumonia | 14.47 | 10.54 | 8 | 105747 | 9514 | 29459258 |
Acute hepatic failure | 14.27 | 10.54 | 13 | 105742 | 11939 | 29456833 |
Amimia | 14.18 | 10.54 | 4 | 105751 | 8 | 29468764 |
Mania | 14.16 | 10.54 | 65 | 105690 | 8598 | 29460174 |
Prothrombin time shortened | 14.14 | 10.54 | 21 | 105734 | 1377 | 29467395 |
Liver function test increased | 14.10 | 10.54 | 13 | 105742 | 11872 | 29456900 |
Dissociative disorder | 13.99 | 10.54 | 9 | 105746 | 204 | 29468568 |
Psychomotor skills impaired | 13.97 | 10.54 | 30 | 105725 | 2631 | 29466141 |
Sepsis pasteurella | 13.91 | 10.54 | 3 | 105752 | 0 | 29468772 |
Blood lactate dehydrogenase increased | 13.84 | 10.54 | 30 | 105725 | 19179 | 29449593 |
Prostate cancer | 13.77 | 10.54 | 46 | 105709 | 25481 | 29443291 |
Hyporesponsive to stimuli | 13.76 | 10.54 | 17 | 105738 | 934 | 29467838 |
Myositis | 13.75 | 10.54 | 10 | 105745 | 10273 | 29458499 |
Osteoporosis | 13.73 | 10.54 | 11 | 105744 | 10758 | 29458014 |
Drug screen negative | 13.72 | 10.54 | 8 | 105747 | 151 | 29468621 |
Exposure via inhalation | 13.71 | 10.54 | 5 | 105750 | 29 | 29468743 |
Arthropathy | 13.68 | 10.54 | 36 | 105719 | 21518 | 29447254 |
Panic reaction | 13.66 | 10.54 | 20 | 105735 | 1295 | 29467477 |
Inflammation | 13.65 | 10.54 | 39 | 105716 | 22689 | 29446083 |
Scleroderma renal crisis | 13.55 | 10.54 | 7 | 105748 | 103 | 29468669 |
Cholangitis | 13.53 | 10.54 | 5 | 105750 | 7532 | 29461240 |
Physical assault | 13.52 | 10.54 | 18 | 105737 | 1066 | 29467706 |
Oedema | 13.48 | 10.54 | 87 | 105668 | 40396 | 29428376 |
Osteonecrosis of jaw | 13.44 | 10.54 | 24 | 105731 | 16486 | 29452286 |
Tumour lysis syndrome | 13.39 | 10.54 | 18 | 105737 | 13866 | 29454906 |
Femoral artery aneurysm | 13.23 | 10.54 | 8 | 105747 | 162 | 29468610 |
Hyperhidrosis | 13.19 | 10.54 | 313 | 105442 | 64227 | 29404545 |
Impatience | 13.13 | 10.54 | 10 | 105745 | 299 | 29468473 |
Therapeutic response decreased | 13.01 | 10.54 | 45 | 105710 | 24666 | 29444106 |
Squamous cell carcinoma of skin | 12.98 | 10.54 | 9 | 105746 | 9477 | 29459295 |
Full blood count abnormal | 12.98 | 10.54 | 21 | 105734 | 14992 | 29453780 |
Adrenergic syndrome | 12.92 | 10.54 | 6 | 105749 | 69 | 29468703 |
Incision site pain | 12.89 | 10.54 | 23 | 105732 | 1760 | 29467012 |
Central nervous system necrosis | 12.86 | 10.54 | 7 | 105748 | 115 | 29468657 |
Second primary malignancy | 12.82 | 10.54 | 4 | 105751 | 6701 | 29462071 |
Bipolar disorder | 12.77 | 10.54 | 33 | 105722 | 3262 | 29465510 |
Hypocalcaemia | 12.75 | 10.54 | 35 | 105720 | 20630 | 29448142 |
Judgement impaired | 12.71 | 10.54 | 13 | 105742 | 579 | 29468193 |
Feeling jittery | 12.68 | 10.54 | 35 | 105720 | 3598 | 29465174 |
Haemoconcentration | 12.68 | 10.54 | 5 | 105750 | 37 | 29468735 |
Euphoric mood | 12.62 | 10.54 | 42 | 105713 | 4783 | 29463989 |
Victim of homicide | 12.60 | 10.54 | 7 | 105748 | 120 | 29468652 |
Peripheral nerve paresis | 12.56 | 10.54 | 5 | 105750 | 38 | 29468734 |
Troponin T increased | 12.53 | 10.54 | 20 | 105735 | 1397 | 29467375 |
Low birth weight baby | 12.53 | 10.54 | 4 | 105751 | 6604 | 29462168 |
Theft | 12.49 | 10.54 | 9 | 105746 | 247 | 29468525 |
Aspartate aminotransferase increased | 12.44 | 10.54 | 145 | 105610 | 59580 | 29409192 |
Prescription drug used without a prescription | 12.36 | 10.54 | 19 | 105736 | 1285 | 29467487 |
Medication error | 12.32 | 10.54 | 123 | 105632 | 21088 | 29447684 |
Progressive multifocal leukoencephalopathy | 12.30 | 10.54 | 8 | 105747 | 8711 | 29460061 |
Paradoxical drug reaction | 12.26 | 10.54 | 29 | 105726 | 2712 | 29466060 |
Septic shock | 12.23 | 10.54 | 154 | 105601 | 62406 | 29406366 |
Mobility decreased | 12.23 | 10.54 | 49 | 105706 | 25731 | 29443041 |
Chloasma | 12.17 | 10.54 | 4 | 105751 | 16 | 29468756 |
Cellulitis | 12.17 | 10.54 | 105 | 105650 | 45735 | 29423037 |
Upper gastrointestinal haemorrhage | 12.16 | 10.54 | 39 | 105716 | 21875 | 29446897 |
Therapy non-responder | 12.13 | 10.54 | 63 | 105692 | 30848 | 29437924 |
Blood alcohol increased | 12.13 | 10.54 | 14 | 105741 | 716 | 29468056 |
Hallucination | 12.12 | 10.54 | 226 | 105529 | 44486 | 29424286 |
Amnestic disorder | 12.11 | 10.54 | 8 | 105747 | 190 | 29468582 |
Electrocardiogram QT prolonged | 12.10 | 10.54 | 189 | 105566 | 35948 | 29432824 |
Conversion disorder | 12.06 | 10.54 | 10 | 105745 | 339 | 29468433 |
Lip swelling | 12.06 | 10.54 | 16 | 105739 | 12394 | 29456378 |
Pulseless electrical activity | 12.01 | 10.54 | 4 | 105751 | 6430 | 29462342 |
Nervous system disorder | 11.95 | 10.54 | 82 | 105673 | 12592 | 29456180 |
Clostridium difficile colitis | 11.88 | 10.54 | 18 | 105737 | 13194 | 29455578 |
Oropharyngeal pain | 11.88 | 10.54 | 59 | 105696 | 29226 | 29439546 |
Product use issue | 11.87 | 10.54 | 122 | 105633 | 51322 | 29417450 |
Benign mesenteric neoplasm | 11.84 | 10.54 | 3 | 105752 | 3 | 29468769 |
Shoplifting | 11.84 | 10.54 | 3 | 105752 | 3 | 29468769 |
Personality change | 11.80 | 10.54 | 40 | 105715 | 4598 | 29464174 |
Colitis microscopic | 11.80 | 10.54 | 22 | 105733 | 1741 | 29467031 |
Conjunctivitis | 11.75 | 10.54 | 7 | 105748 | 7991 | 29460781 |
Substance-induced mood disorder | 11.75 | 10.54 | 6 | 105749 | 86 | 29468686 |
Basal cell carcinoma | 11.70 | 10.54 | 27 | 105728 | 16883 | 29451889 |
Acute stress disorder | 11.65 | 10.54 | 7 | 105748 | 140 | 29468632 |
Hypoventilation | 11.58 | 10.54 | 29 | 105726 | 2812 | 29465960 |
Hepatic enzyme increased | 11.58 | 10.54 | 72 | 105683 | 33727 | 29435045 |
Sluggishness | 11.51 | 10.54 | 30 | 105725 | 2981 | 29465791 |
Hypothermia | 11.36 | 10.54 | 64 | 105691 | 9175 | 29459597 |
Haematuria | 11.32 | 10.54 | 102 | 105653 | 44037 | 29424735 |
Circulatory collapse | 11.24 | 10.54 | 32 | 105723 | 18641 | 29450131 |
Sleep disorder | 11.22 | 10.54 | 135 | 105620 | 24251 | 29444521 |
Body temperature decreased | 11.15 | 10.54 | 13 | 105742 | 10651 | 29458121 |
Cardiorenal syndrome | 11.13 | 10.54 | 13 | 105742 | 673 | 29468099 |
Urinary tract infection | 11.04 | 10.54 | 187 | 105568 | 72167 | 29396605 |
Erythema multiforme | 11.00 | 10.54 | 7 | 105748 | 7710 | 29461062 |
Extrapyramidal disorder | 10.77 | 10.54 | 71 | 105684 | 10760 | 29458012 |
Sputum discoloured | 10.74 | 10.54 | 5 | 105750 | 6558 | 29462214 |
Respiratory acidosis | 10.73 | 10.54 | 37 | 105718 | 4291 | 29464481 |
Malaise | 10.72 | 10.54 | 464 | 105291 | 159138 | 29309634 |
Osteonecrosis | 10.70 | 10.54 | 20 | 105735 | 13499 | 29455273 |
Pulmonary fibrosis | 10.69 | 10.54 | 25 | 105730 | 15557 | 29453215 |
Ear infection | 10.67 | 10.54 | 8 | 105747 | 8092 | 29460680 |
Injection site pain | 10.66 | 10.54 | 70 | 105685 | 32376 | 29436396 |
Visceral congestion | 10.63 | 10.54 | 11 | 105744 | 497 | 29468275 |
Apathy | 10.61 | 10.54 | 47 | 105708 | 6124 | 29462648 |
Atrial flutter | 10.60 | 10.54 | 21 | 105734 | 13873 | 29454899 |
Paranoia | 10.59 | 10.54 | 66 | 105689 | 9811 | 29458961 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug abuse | 11923.73 | 9.89 | 7147 | 256474 | 125227 | 64109884 |
Completed suicide | 6041.10 | 9.89 | 5897 | 257724 | 218517 | 64016594 |
Toxicity to various agents | 3562.92 | 9.89 | 5758 | 257863 | 357755 | 63877356 |
Respiratory arrest | 3342.65 | 9.89 | 2293 | 261328 | 50692 | 64184419 |
Poisoning | 2442.39 | 9.89 | 1363 | 262258 | 20516 | 64214595 |
Sopor | 2441.08 | 9.89 | 1517 | 262104 | 28144 | 64206967 |
Cardio-respiratory arrest | 1998.33 | 9.89 | 2230 | 261391 | 96163 | 64138948 |
Cardiac arrest | 1811.65 | 9.89 | 2661 | 260960 | 151403 | 64083708 |
Suicide attempt | 1324.96 | 9.89 | 1541 | 262080 | 69466 | 64165645 |
Intentional overdose | 1236.04 | 9.89 | 1675 | 261946 | 88269 | 64146842 |
Intentional product misuse | 1111.72 | 9.89 | 1423 | 262198 | 70872 | 64164239 |
Coma | 1096.58 | 9.89 | 1560 | 262061 | 86055 | 64149056 |
Overdose | 1088.02 | 9.89 | 2164 | 261457 | 157402 | 64077709 |
Drug dependence | 1060.30 | 9.89 | 964 | 262657 | 32348 | 64202763 |
Poisoning deliberate | 939.85 | 9.89 | 621 | 263000 | 12837 | 64222274 |
Intentional self-injury | 593.25 | 9.89 | 661 | 262960 | 28383 | 64206728 |
Somnolence | 551.70 | 9.89 | 1958 | 261663 | 201687 | 64033424 |
Death | 503.61 | 9.89 | 3534 | 260087 | 479171 | 63755940 |
Exposure via ingestion | 431.71 | 9.89 | 262 | 263359 | 4640 | 64230471 |
Drug ineffective | 399.89 | 9.89 | 1924 | 261697 | 838323 | 63396788 |
Off label use | 366.88 | 9.89 | 1342 | 262279 | 631464 | 63603647 |
Drug withdrawal syndrome | 353.12 | 9.89 | 531 | 263090 | 30760 | 64204351 |
Synovitis | 337.59 | 9.89 | 16 | 263605 | 99074 | 64136037 |
Substance abuse | 331.54 | 9.89 | 287 | 263334 | 9005 | 64226106 |
Drug use disorder | 298.72 | 9.89 | 226 | 263395 | 5828 | 64229283 |
Bradyphrenia | 296.78 | 9.89 | 271 | 263350 | 9135 | 64225976 |
Withdrawal syndrome | 294.55 | 9.89 | 419 | 263202 | 23073 | 64212038 |
Infusion related reaction | 288.85 | 9.89 | 156 | 263465 | 164311 | 64070800 |
Drug abuser | 286.99 | 9.89 | 217 | 263404 | 5591 | 64229520 |
Treatment failure | 285.17 | 9.89 | 64 | 263557 | 116752 | 64118359 |
Drug intolerance | 273.80 | 9.89 | 220 | 263401 | 187772 | 64047339 |
Anxiety | 265.89 | 9.89 | 1574 | 262047 | 201075 | 64034036 |
Contraindicated product administered | 263.36 | 9.89 | 59 | 263562 | 107770 | 64127341 |
Joint swelling | 256.93 | 9.89 | 301 | 263320 | 215081 | 64020030 |
Lower respiratory tract infection | 236.70 | 9.89 | 49 | 263572 | 94565 | 64140546 |
Suicidal ideation | 235.03 | 9.89 | 701 | 262920 | 65841 | 64169270 |
Pemphigus | 227.70 | 9.89 | 4 | 263617 | 60697 | 64174414 |
Accidental overdose | 224.39 | 9.89 | 452 | 263169 | 33105 | 64202006 |
Depression | 216.02 | 9.89 | 1385 | 262236 | 181906 | 64053205 |
Rheumatoid arthritis | 212.04 | 9.89 | 215 | 263406 | 164079 | 64071032 |
Hand deformity | 207.92 | 9.89 | 12 | 263609 | 62759 | 64172352 |
Mydriasis | 197.71 | 9.89 | 277 | 263344 | 15035 | 64220076 |
Pyrexia | 193.64 | 9.89 | 1413 | 262208 | 557231 | 63677880 |
Miosis | 192.54 | 9.89 | 254 | 263367 | 13012 | 64222099 |
Agitation | 192.19 | 9.89 | 793 | 262828 | 87574 | 64147537 |
Febrile neutropenia | 186.74 | 9.89 | 299 | 263322 | 187358 | 64047753 |
Anti-cyclic citrullinated peptide antibody positive | 182.95 | 9.89 | 4 | 263617 | 49558 | 64185553 |
Arthropathy | 174.26 | 9.89 | 143 | 263478 | 120824 | 64114287 |
Pericarditis | 165.71 | 9.89 | 28 | 263593 | 62488 | 64172623 |
Nasopharyngitis | 163.50 | 9.89 | 348 | 263273 | 195725 | 64039386 |
Infection | 161.91 | 9.89 | 319 | 263302 | 184561 | 64050550 |
Systemic lupus erythematosus | 160.80 | 9.89 | 58 | 263563 | 77554 | 64157557 |
Prescription form tampering | 158.07 | 9.89 | 59 | 263562 | 315 | 64234796 |
Respiratory depression | 149.89 | 9.89 | 310 | 263311 | 23133 | 64211978 |
Maternal exposure during pregnancy | 146.15 | 9.89 | 107 | 263514 | 95777 | 64139334 |
Bradypnoea | 144.25 | 9.89 | 139 | 263482 | 5020 | 64230091 |
Pneumonia | 143.93 | 9.89 | 1528 | 262093 | 558048 | 63677063 |
Arthralgia | 140.64 | 9.89 | 1145 | 262476 | 441115 | 63793996 |
Panic attack | 138.60 | 9.89 | 281 | 263340 | 20672 | 64214439 |
Drug screen positive | 132.01 | 9.89 | 139 | 263482 | 5590 | 64229521 |
Depressed level of consciousness | 128.31 | 9.89 | 665 | 262956 | 80771 | 64154340 |
Loss of consciousness | 127.77 | 9.89 | 1040 | 262581 | 147325 | 64087786 |
Rash | 126.95 | 9.89 | 1230 | 262391 | 457319 | 63777792 |
Hypersensitivity | 125.22 | 9.89 | 399 | 263222 | 196053 | 64039058 |
Therapeutic product effect decreased | 124.19 | 9.89 | 174 | 263447 | 115177 | 64119934 |
Duodenal ulcer perforation | 123.29 | 9.89 | 4 | 263617 | 34621 | 64200490 |
Hepatic enzyme increased | 121.87 | 9.89 | 215 | 263406 | 129728 | 64105383 |
C-reactive protein increased | 121.49 | 9.89 | 125 | 263496 | 94784 | 64140327 |
Tremor | 116.48 | 9.89 | 1018 | 262603 | 147212 | 64087899 |
Glossodynia | 115.51 | 9.89 | 60 | 263561 | 64636 | 64170475 |
Sepsis | 114.92 | 9.89 | 517 | 263104 | 229824 | 64005287 |
Victim of chemical submission | 114.76 | 9.89 | 44 | 263577 | 256 | 64234855 |
Cough | 112.37 | 9.89 | 748 | 262873 | 301400 | 63933711 |
General physical health deterioration | 109.22 | 9.89 | 447 | 263174 | 203978 | 64031133 |
Insomnia | 107.88 | 9.89 | 1260 | 262361 | 196576 | 64038535 |
Swelling | 107.36 | 9.89 | 318 | 263303 | 159900 | 64075211 |
Product use in unapproved indication | 106.84 | 9.89 | 367 | 263254 | 176251 | 64058860 |
Peripheral swelling | 102.79 | 9.89 | 472 | 263149 | 208681 | 64026430 |
Helicobacter infection | 102.06 | 9.89 | 17 | 263604 | 38345 | 64196766 |
Bradykinesia | 102.06 | 9.89 | 130 | 263491 | 6430 | 64228681 |
Drug resistance | 101.73 | 9.89 | 12 | 263609 | 35090 | 64200021 |
Renal impairment | 99.38 | 9.89 | 256 | 263365 | 134761 | 64100350 |
Neutropenia | 99.02 | 9.89 | 574 | 263047 | 239050 | 63996061 |
Altered state of consciousness | 97.72 | 9.89 | 359 | 263262 | 37543 | 64197568 |
Disturbance in attention | 97.58 | 9.89 | 379 | 263242 | 40695 | 64194416 |
Alcohol abuse | 96.59 | 9.89 | 109 | 263512 | 4743 | 64230368 |
Cytomegalovirus infection | 93.56 | 9.89 | 19 | 263602 | 37180 | 64197931 |
Therapeutic product effect incomplete | 92.76 | 9.89 | 176 | 263445 | 103306 | 64131805 |
Accidental death | 92.35 | 9.89 | 94 | 263527 | 3631 | 64231480 |
Product use issue | 91.25 | 9.89 | 316 | 263305 | 151399 | 64083712 |
Wound | 87.78 | 9.89 | 110 | 263511 | 76367 | 64158744 |
Folliculitis | 85.40 | 9.89 | 11 | 263610 | 30066 | 64205045 |
Sleep disorder due to general medical condition, insomnia type | 84.08 | 9.89 | 6 | 263615 | 26264 | 64208847 |
Alopecia | 83.73 | 9.89 | 370 | 263251 | 165320 | 64069791 |
Discomfort | 81.20 | 9.89 | 128 | 263493 | 80750 | 64154361 |
Mucosal inflammation | 77.20 | 9.89 | 85 | 263536 | 62499 | 64172612 |
Amnesia | 76.58 | 9.89 | 395 | 263226 | 47874 | 64187237 |
Hepatocellular injury | 76.57 | 9.89 | 377 | 263244 | 44858 | 64190253 |
Disorientation | 76.53 | 9.89 | 439 | 263182 | 55389 | 64179722 |
Neutropenic sepsis | 75.41 | 9.89 | 5 | 263616 | 23267 | 64211844 |
Platelet count decreased | 75.13 | 9.89 | 391 | 263230 | 167320 | 64067791 |
Aggression | 73.81 | 9.89 | 379 | 263242 | 45853 | 64189258 |
Stomatitis | 72.35 | 9.89 | 219 | 263402 | 109386 | 64125725 |
Dyspnoea | 72.14 | 9.89 | 2314 | 261307 | 716360 | 63518751 |
Anaemia | 70.79 | 9.89 | 1105 | 262516 | 377575 | 63857536 |
Sinusitis | 70.66 | 9.89 | 331 | 263290 | 145597 | 64089514 |
Pancytopenia | 70.61 | 9.89 | 323 | 263298 | 142986 | 64092125 |
Suspected suicide | 69.46 | 9.89 | 126 | 263495 | 8528 | 64226583 |
Myelosuppression | 69.42 | 9.89 | 8 | 263613 | 23822 | 64211289 |
Abnormal behaviour | 69.36 | 9.89 | 297 | 263324 | 33325 | 64201786 |
Neutrophil count decreased | 66.83 | 9.89 | 134 | 263487 | 77062 | 64158049 |
Condition aggravated | 65.86 | 9.89 | 1098 | 262523 | 371328 | 63863783 |
Confusional state | 65.63 | 9.89 | 1462 | 262159 | 259682 | 63975429 |
Abdominal discomfort | 64.41 | 9.89 | 458 | 263163 | 181864 | 64053247 |
Homicide | 63.59 | 9.89 | 46 | 263575 | 1105 | 64234006 |
Hypokinesia | 63.52 | 9.89 | 180 | 263441 | 16416 | 64218695 |
Toxicologic test abnormal | 63.26 | 9.89 | 47 | 263574 | 1178 | 64233933 |
Gastrointestinal disorder | 62.29 | 9.89 | 175 | 263446 | 89534 | 64145577 |
Malignant neoplasm progression | 62.01 | 9.89 | 244 | 263377 | 112627 | 64122484 |
Hepatic function abnormal | 61.55 | 9.89 | 105 | 263516 | 64208 | 64170903 |
Nervousness | 60.91 | 9.89 | 261 | 263360 | 29295 | 64205816 |
Diarrhoea | 60.16 | 9.89 | 2381 | 261240 | 720323 | 63514788 |
Dependence | 60.13 | 9.89 | 58 | 263563 | 2097 | 64233014 |
Irritability | 59.89 | 9.89 | 303 | 263318 | 36443 | 64198668 |
Memory impairment | 58.45 | 9.89 | 571 | 263050 | 85111 | 64150000 |
Euphoric mood | 58.11 | 9.89 | 100 | 263521 | 6491 | 64228620 |
Psychomotor skills impaired | 57.94 | 9.89 | 75 | 263546 | 3770 | 64231341 |
Muscle injury | 57.81 | 9.89 | 18 | 263603 | 26419 | 64208692 |
Musculoskeletal stiffness | 55.30 | 9.89 | 287 | 263334 | 122919 | 64112192 |
Blood pressure fluctuation | 55.06 | 9.89 | 79 | 263542 | 51792 | 64183319 |
Blood creatinine increased | 54.57 | 9.89 | 328 | 263293 | 135454 | 64099657 |
Crying | 54.07 | 9.89 | 193 | 263428 | 19897 | 64215214 |
Cardiac failure | 53.08 | 9.89 | 320 | 263301 | 132053 | 64103058 |
Postmortem blood drug level abnormal | 52.94 | 9.89 | 33 | 263588 | 614 | 64234497 |
Substance use disorder | 52.54 | 9.89 | 27 | 263594 | 340 | 64234771 |
COVID-19 | 52.27 | 9.89 | 118 | 263503 | 65022 | 64170089 |
Psychomotor hyperactivity | 50.76 | 9.89 | 152 | 263469 | 14299 | 64220812 |
Counterfeit product administered | 50.51 | 9.89 | 19 | 263602 | 104 | 64235007 |
Unresponsive to stimuli | 50.44 | 9.89 | 366 | 263255 | 50027 | 64185084 |
Impaired healing | 49.79 | 9.89 | 108 | 263513 | 60365 | 64174746 |
Acute kidney injury | 49.47 | 9.89 | 1428 | 262193 | 447812 | 63787299 |
Drug detoxification | 49.29 | 9.89 | 23 | 263598 | 231 | 64234880 |
Fall | 48.83 | 9.89 | 2126 | 261495 | 414700 | 63820411 |
Feeling abnormal | 48.67 | 9.89 | 792 | 262829 | 132810 | 64102301 |
Alcohol interaction | 48.66 | 9.89 | 74 | 263547 | 4327 | 64230784 |
Blister | 47.74 | 9.89 | 170 | 263451 | 80797 | 64154314 |
Delirium | 47.62 | 9.89 | 462 | 263159 | 68732 | 64166379 |
Pneumocystis jirovecii pneumonia | 47.32 | 9.89 | 27 | 263594 | 27607 | 64207504 |
Road traffic accident | 46.97 | 9.89 | 249 | 263372 | 30496 | 64204615 |
Haemoglobin decreased | 46.61 | 9.89 | 541 | 263080 | 194522 | 64040589 |
Thinking abnormal | 45.86 | 9.89 | 127 | 263494 | 11429 | 64223682 |
Blood pressure systolic increased | 45.28 | 9.89 | 83 | 263538 | 49370 | 64185741 |
Inflammation | 44.88 | 9.89 | 128 | 263493 | 65172 | 64169939 |
Wheezing | 44.37 | 9.89 | 174 | 263447 | 80405 | 64154706 |
Herpes zoster | 44.24 | 9.89 | 170 | 263451 | 79017 | 64156094 |
Blood pressure diastolic decreased | 43.96 | 9.89 | 18 | 263603 | 22283 | 64212828 |
Asthma | 43.76 | 9.89 | 220 | 263401 | 95005 | 64140106 |
Anhedonia | 43.35 | 9.89 | 139 | 263482 | 13567 | 64221544 |
Vertigo | 43.08 | 9.89 | 399 | 263222 | 58612 | 64176499 |
Drug hypersensitivity | 43.01 | 9.89 | 698 | 262923 | 237117 | 63997994 |
Medication error | 42.82 | 9.89 | 350 | 263271 | 49616 | 64185495 |
Irritable bowel syndrome | 42.61 | 9.89 | 54 | 263567 | 37315 | 64197796 |
Sedation | 42.57 | 9.89 | 303 | 263318 | 41159 | 64193952 |
Neurotoxicity | 42.50 | 9.89 | 30 | 263591 | 27374 | 64207737 |
Product counterfeit | 41.93 | 9.89 | 20 | 263601 | 212 | 64234899 |
Transplant rejection | 41.51 | 9.89 | 10 | 263611 | 17391 | 64217720 |
Serotonin syndrome | 41.46 | 9.89 | 289 | 263332 | 38993 | 64196118 |
Mobility decreased | 41.36 | 9.89 | 195 | 263426 | 85645 | 64149466 |
Sluggishness | 41.07 | 9.89 | 79 | 263542 | 5591 | 64229520 |
Dysarthria | 41.05 | 9.89 | 397 | 263224 | 59009 | 64176102 |
Alcohol use | 40.80 | 9.89 | 70 | 263551 | 4532 | 64230579 |
Gastrointestinal haemorrhage | 40.79 | 9.89 | 345 | 263276 | 131967 | 64103144 |
Major depression | 40.49 | 9.89 | 95 | 263526 | 7721 | 64227390 |
Rheumatoid nodule | 40.17 | 9.89 | 3 | 263618 | 12648 | 64222463 |
Ill-defined disorder | 39.39 | 9.89 | 75 | 263546 | 43977 | 64191134 |
Obstructive airways disorder | 39.21 | 9.89 | 23 | 263598 | 23162 | 64211949 |
Disease progression | 39.07 | 9.89 | 380 | 263241 | 141300 | 64093811 |
Red blood cell sedimentation rate increased | 38.99 | 9.89 | 42 | 263579 | 31193 | 64203918 |
Pulmonary congestion | 38.97 | 9.89 | 197 | 263424 | 23683 | 64211428 |
Anger | 38.82 | 9.89 | 147 | 263474 | 15594 | 64219517 |
Poverty of speech | 38.68 | 9.89 | 26 | 263595 | 553 | 64234558 |
Mania | 38.45 | 9.89 | 150 | 263471 | 16136 | 64218975 |
Hallucination, visual | 38.22 | 9.89 | 219 | 263402 | 27615 | 64207496 |
Ascites | 38.02 | 9.89 | 128 | 263493 | 61873 | 64173238 |
Self-medication | 38.01 | 9.89 | 64 | 263557 | 4081 | 64231030 |
Anaphylactic reaction | 37.34 | 9.89 | 149 | 263472 | 68515 | 64166596 |
Electrocardiogram QT prolonged | 37.21 | 9.89 | 492 | 263129 | 78956 | 64156155 |
Speech disorder | 37.13 | 9.89 | 331 | 263290 | 48110 | 64187001 |
Anticholinergic syndrome | 37.03 | 9.89 | 50 | 263571 | 2619 | 64232492 |
Alcohol poisoning | 36.78 | 9.89 | 64 | 263557 | 4191 | 64230920 |
Pruritus | 36.66 | 9.89 | 984 | 262637 | 311416 | 63923695 |
Skin ulcer | 36.64 | 9.89 | 78 | 263543 | 43896 | 64191215 |
Haematochezia | 36.11 | 9.89 | 144 | 263477 | 66229 | 64168882 |
Urinary retention | 36.08 | 9.89 | 333 | 263288 | 48868 | 64186243 |
Inadequate analgesia | 35.92 | 9.89 | 61 | 263560 | 3917 | 64231194 |
Therapy non-responder | 35.84 | 9.89 | 143 | 263478 | 65756 | 64169355 |
Panic disorder | 35.77 | 9.89 | 50 | 263571 | 2707 | 64232404 |
Drug eruption | 35.50 | 9.89 | 58 | 263563 | 36078 | 64199033 |
Cellulitis | 35.17 | 9.89 | 231 | 263390 | 93426 | 64141685 |
Emotional distress | 34.50 | 9.89 | 259 | 263362 | 35779 | 64199332 |
Body temperature decreased | 34.48 | 9.89 | 33 | 263588 | 25895 | 64209216 |
Cerebral haemorrhage | 33.76 | 9.89 | 102 | 263519 | 50988 | 64184123 |
Chemical submission | 33.30 | 9.89 | 17 | 263604 | 211 | 64234900 |
Asphyxia | 33.01 | 9.89 | 100 | 263521 | 9466 | 64225645 |
White blood cell count decreased | 32.75 | 9.89 | 451 | 263170 | 157386 | 64077725 |
Alanine aminotransferase increased | 32.65 | 9.89 | 387 | 263234 | 138644 | 64096467 |
Blood pressure diastolic abnormal | 32.33 | 9.89 | 5 | 263616 | 11912 | 64223199 |
Persistent genital arousal disorder | 32.14 | 9.89 | 17 | 263604 | 228 | 64234883 |
Respiratory acidosis | 32.13 | 9.89 | 101 | 263520 | 9754 | 64225357 |
Distributive shock | 32.12 | 9.89 | 39 | 263582 | 1836 | 64233275 |
Diabetic ketoacidosis | 32.12 | 9.89 | 45 | 263576 | 29800 | 64205311 |
Septic shock | 32.01 | 9.89 | 276 | 263345 | 105161 | 64129950 |
Urticaria | 31.99 | 9.89 | 417 | 263204 | 146900 | 64088211 |
Psoriatic arthropathy | 31.87 | 9.89 | 82 | 263539 | 43199 | 64191912 |
Basal cell carcinoma | 31.71 | 9.89 | 48 | 263573 | 30790 | 64204321 |
Extrapyramidal disorder | 31.70 | 9.89 | 161 | 263460 | 19391 | 64215720 |
Injury | 31.52 | 9.89 | 359 | 263262 | 55633 | 64179478 |
Drug withdrawal convulsions | 31.27 | 9.89 | 41 | 263580 | 2087 | 64233024 |
Metastases to liver | 31.23 | 9.89 | 31 | 263590 | 23910 | 64211201 |
Leukopenia | 31.19 | 9.89 | 264 | 263357 | 100978 | 64134133 |
Haemorrhage | 31.18 | 9.89 | 193 | 263428 | 79158 | 64155953 |
Exposure during pregnancy | 31.00 | 9.89 | 188 | 263433 | 77487 | 64157624 |
Knee arthroplasty | 30.80 | 9.89 | 39 | 263582 | 26960 | 64208151 |
Bone marrow failure | 30.78 | 9.89 | 97 | 263524 | 47855 | 64187256 |
Abulia | 30.73 | 9.89 | 27 | 263594 | 864 | 64234247 |
Pleural effusion | 30.60 | 9.89 | 350 | 263271 | 126209 | 64108902 |
Adjustment disorder with mixed anxiety and depressed mood | 30.58 | 9.89 | 12 | 263609 | 75 | 64235036 |
Liver function test abnormal | 30.37 | 9.89 | 132 | 263489 | 59269 | 64175842 |
Bronchiectasis | 30.26 | 9.89 | 10 | 263611 | 14130 | 64220981 |
Intentional product use issue | 30.14 | 9.89 | 247 | 263374 | 95117 | 64139994 |
Multiple organ dysfunction syndrome | 30.11 | 9.89 | 267 | 263354 | 101146 | 64133965 |
Venoocclusive liver disease | 30.10 | 9.89 | 3 | 263618 | 10012 | 64225099 |
Therapeutic response decreased | 29.82 | 9.89 | 111 | 263510 | 52077 | 64183034 |
Arthritis | 29.35 | 9.89 | 211 | 263410 | 83603 | 64151508 |
Productive cough | 29.31 | 9.89 | 177 | 263444 | 73026 | 64162085 |
Bone erosion | 29.00 | 9.89 | 6 | 263615 | 11589 | 64223522 |
Acute myeloid leukaemia | 28.97 | 9.89 | 42 | 263579 | 27421 | 64207690 |
Osteonecrosis of jaw | 28.90 | 9.89 | 76 | 263545 | 39749 | 64195362 |
Narcotic bowel syndrome | 28.80 | 9.89 | 16 | 263605 | 238 | 64234873 |
Gun shot wound | 28.49 | 9.89 | 28 | 263593 | 1036 | 64234075 |
Interstitial lung disease | 28.27 | 9.89 | 259 | 263362 | 97473 | 64137638 |
Respiratory failure | 28.16 | 9.89 | 476 | 263145 | 160707 | 64074404 |
Immobilisation prolonged | 27.86 | 9.89 | 12 | 263609 | 98 | 64235013 |
Tenosynovitis | 27.84 | 9.89 | 7 | 263614 | 11826 | 64223285 |
Aplastic anaemia | 27.82 | 9.89 | 11 | 263610 | 13909 | 64221202 |
Pneumonia aspiration | 27.73 | 9.89 | 367 | 263254 | 58904 | 64176207 |
Liver disorder | 27.62 | 9.89 | 118 | 263503 | 53233 | 64181878 |
Hallucination, auditory | 27.12 | 9.89 | 139 | 263482 | 16800 | 64218311 |
Wrong patient | 26.99 | 9.89 | 14 | 263607 | 180 | 64234931 |
Tumour lysis syndrome | 26.73 | 9.89 | 24 | 263597 | 19416 | 64215695 |
Slow speech | 26.52 | 9.89 | 37 | 263584 | 2000 | 64233111 |
Hyperleukocytosis | 26.47 | 9.89 | 37 | 263584 | 2003 | 64233108 |
Drug tolerance | 26.28 | 9.89 | 69 | 263552 | 6016 | 64229095 |
Toxic epidermal necrolysis | 26.16 | 9.89 | 72 | 263549 | 37094 | 64198017 |
Apathy | 26.15 | 9.89 | 103 | 263518 | 11129 | 64223982 |
Psychomotor retardation | 26.09 | 9.89 | 62 | 263559 | 5081 | 64230030 |
Hallucination | 25.93 | 9.89 | 430 | 263191 | 72358 | 64162753 |
Injection site erythema | 25.89 | 9.89 | 176 | 263445 | 70624 | 64164487 |
Paramnesia | 25.82 | 9.89 | 8 | 263613 | 21 | 64235090 |
Liver function test increased | 25.75 | 9.89 | 55 | 263566 | 30915 | 64204196 |
Dysphoria | 25.70 | 9.89 | 56 | 263565 | 4332 | 64230779 |
Live birth | 25.65 | 9.89 | 7 | 263614 | 11197 | 64223914 |
Tubulointerstitial nephritis | 25.61 | 9.89 | 55 | 263566 | 30854 | 64204257 |
Hypervolaemia | 25.61 | 9.89 | 76 | 263545 | 38209 | 64196902 |
Thrombocytopenia | 25.43 | 9.89 | 708 | 262913 | 223093 | 64012018 |
Fear | 25.31 | 9.89 | 155 | 263466 | 20016 | 64215095 |
Aspergillus infection | 25.31 | 9.89 | 18 | 263603 | 16361 | 64218750 |
Cyanosis | 25.17 | 9.89 | 166 | 263455 | 21989 | 64213122 |
Haemophagocytic lymphohistiocytosis | 25.11 | 9.89 | 21 | 263600 | 17588 | 64217523 |
Prescription drug used without a prescription | 24.99 | 9.89 | 41 | 263580 | 2559 | 64232552 |
Rheumatic fever | 24.99 | 9.89 | 4 | 263617 | 9290 | 64225821 |
Suspected counterfeit product | 24.94 | 9.89 | 19 | 263602 | 495 | 64234616 |
Pathogen resistance | 24.93 | 9.89 | 10 | 263611 | 12533 | 64222578 |
Heart rate decreased | 24.85 | 9.89 | 128 | 263493 | 54939 | 64180172 |
Nephropathy toxic | 24.84 | 9.89 | 21 | 263600 | 17493 | 64217618 |
Respiratory rate decreased | 24.82 | 9.89 | 56 | 263565 | 4435 | 64230676 |
Cardio-respiratory distress | 24.79 | 9.89 | 15 | 263606 | 264 | 64234847 |
Mental disorder | 24.72 | 9.89 | 189 | 263432 | 26256 | 64208855 |
Bronchopulmonary aspergillosis | 24.56 | 9.89 | 25 | 263596 | 19060 | 64216051 |
Feeling jittery | 24.33 | 9.89 | 97 | 263524 | 10538 | 64224573 |
Nightmare | 24.28 | 9.89 | 158 | 263463 | 20835 | 64214276 |
Blood lactate dehydrogenase increased | 24.10 | 9.89 | 63 | 263558 | 33015 | 64202096 |
Inappropriate schedule of product administration | 23.99 | 9.89 | 251 | 263370 | 92035 | 64143076 |
Cholecystitis chronic | 23.96 | 9.89 | 88 | 263533 | 9199 | 64225912 |
Multiple injuries | 23.94 | 9.89 | 46 | 263575 | 3253 | 64231858 |
Hyporesponsive to stimuli | 23.93 | 9.89 | 33 | 263588 | 1764 | 64233347 |
Pain in extremity | 23.91 | 9.89 | 1004 | 262617 | 302081 | 63933030 |
Blood bilirubin increased | 23.65 | 9.89 | 138 | 263483 | 57415 | 64177696 |
Stevens-Johnson syndrome | 23.63 | 9.89 | 67 | 263554 | 34182 | 64200929 |
Injection site pain | 23.58 | 9.89 | 317 | 263304 | 111091 | 64124020 |
Impaired driving ability | 23.49 | 9.89 | 56 | 263565 | 4598 | 64230513 |
Oropharyngeal pain | 23.39 | 9.89 | 241 | 263380 | 88626 | 64146485 |
Hyperhidrosis | 23.24 | 9.89 | 672 | 262949 | 124248 | 64110863 |
Exposure via inhalation | 23.18 | 9.89 | 10 | 263611 | 82 | 64235029 |
Drug-induced liver injury | 23.08 | 9.89 | 108 | 263513 | 47535 | 64187576 |
Full blood count abnormal | 22.98 | 9.89 | 55 | 263566 | 29702 | 64205409 |
Fatigue | 22.97 | 9.89 | 2695 | 260926 | 746035 | 63489076 |
Myelodysplastic syndrome | 22.91 | 9.89 | 49 | 263572 | 27530 | 64207581 |
Hepatotoxicity | 22.83 | 9.89 | 85 | 263536 | 39877 | 64195234 |
Pneumonitis | 22.76 | 9.89 | 117 | 263504 | 50248 | 64184863 |
Diffuse large B-cell lymphoma | 22.75 | 9.89 | 7 | 263614 | 10354 | 64224757 |
Benzodiazepine drug level abnormal | 22.52 | 9.89 | 5 | 263616 | 0 | 64235111 |
Angioedema | 22.44 | 9.89 | 154 | 263467 | 61667 | 64173444 |
Housebound | 22.15 | 9.89 | 17 | 263604 | 448 | 64234663 |
Enthesopathy | 22.10 | 9.89 | 6 | 263615 | 9632 | 64225479 |
Lymphadenopathy | 21.93 | 9.89 | 107 | 263514 | 46579 | 64188532 |
Homicidal ideation | 21.92 | 9.89 | 44 | 263577 | 3213 | 64231898 |
Suicidal behaviour | 21.87 | 9.89 | 41 | 263580 | 2846 | 64232265 |
Hallucination, gustatory | 21.84 | 9.89 | 9 | 263612 | 65 | 64235046 |
Cerebral infarction | 21.72 | 9.89 | 90 | 263531 | 40954 | 64194157 |
Substance abuser | 21.38 | 9.89 | 10 | 263611 | 101 | 64235010 |
Bacteraemia | 21.38 | 9.89 | 49 | 263572 | 26862 | 64208249 |
Hip arthroplasty | 21.22 | 9.89 | 34 | 263587 | 21317 | 64213794 |
Obsessive-compulsive disorder | 21.19 | 9.89 | 55 | 263566 | 4763 | 64230348 |
Acquired amegakaryocytic thrombocytopenia | 21.18 | 9.89 | 6 | 263615 | 10 | 64235101 |
Renal papillary necrosis | 21.15 | 9.89 | 15 | 263606 | 349 | 64234762 |
Hyponatraemic encephalopathy | 21.15 | 9.89 | 14 | 263607 | 290 | 64234821 |
Prostate cancer | 21.15 | 9.89 | 30 | 263591 | 19765 | 64215346 |
Ankylosing spondylitis | 21.14 | 9.89 | 4 | 263617 | 8230 | 64226881 |
Premature delivery | 21.05 | 9.89 | 27 | 263594 | 18562 | 64216549 |
Erythema | 20.94 | 9.89 | 593 | 263028 | 186477 | 64048634 |
Wrong patient received product | 20.89 | 9.89 | 47 | 263574 | 3715 | 64231396 |
Generalised anxiety disorder | 20.89 | 9.89 | 32 | 263589 | 1883 | 64233228 |
Femur fracture | 20.57 | 9.89 | 71 | 263550 | 34064 | 64201047 |
Withdrawal catatonia | 20.51 | 9.89 | 11 | 263610 | 152 | 64234959 |
Obsessive thoughts | 20.51 | 9.89 | 23 | 263598 | 994 | 64234117 |
Hypochloraemia | 20.49 | 9.89 | 33 | 263588 | 2028 | 64233083 |
Injection site swelling | 20.47 | 9.89 | 93 | 263528 | 41260 | 64193851 |
Adrenal insufficiency | 20.35 | 9.89 | 38 | 263583 | 22449 | 64212662 |
Blood test abnormal | 20.29 | 9.89 | 14 | 263607 | 12929 | 64222182 |
Epstein-Barr virus infection | 20.26 | 9.89 | 13 | 263608 | 12475 | 64222636 |
Tension | 20.25 | 9.89 | 47 | 263574 | 3793 | 64231318 |
Hypersomnia | 20.18 | 9.89 | 144 | 263477 | 19573 | 64215538 |
Mood altered | 20.18 | 9.89 | 123 | 263498 | 15856 | 64219255 |
Haematotoxicity | 20.15 | 9.89 | 14 | 263607 | 12882 | 64222229 |
Electrocardiogram QRS complex prolonged | 20.11 | 9.89 | 83 | 263538 | 9161 | 64225950 |
Upper gastrointestinal haemorrhage | 20.06 | 9.89 | 75 | 263546 | 35145 | 64199966 |
Delusion | 19.88 | 9.89 | 134 | 263487 | 17880 | 64217231 |
Vestibular ischaemia | 19.86 | 9.89 | 6 | 263615 | 14 | 64235097 |
Stupor | 19.81 | 9.89 | 62 | 263559 | 5973 | 64229138 |
Drug tolerance increased | 19.80 | 9.89 | 18 | 263603 | 603 | 64234508 |
Prothrombin time shortened | 19.79 | 9.89 | 39 | 263582 | 2810 | 64232301 |
Hallucinations, mixed | 19.71 | 9.89 | 62 | 263559 | 5990 | 64229121 |
Blood pressure systolic abnormal | 19.64 | 9.89 | 8 | 263613 | 9934 | 64225177 |
Head injury | 19.59 | 9.89 | 213 | 263408 | 32629 | 64202482 |
Inappropriate antidiuretic hormone secretion | 19.56 | 9.89 | 157 | 263464 | 22132 | 64212979 |
Hospitalisation | 19.36 | 9.89 | 205 | 263416 | 75002 | 64160109 |
Clostridium difficile infection | 19.33 | 9.89 | 79 | 263542 | 36084 | 64199027 |
Joint effusion | 19.30 | 9.89 | 16 | 263605 | 13457 | 64221654 |
Substance dependence | 19.25 | 9.89 | 16 | 263605 | 474 | 64234637 |
Atrial fibrillation | 19.23 | 9.89 | 542 | 263079 | 170547 | 64064564 |
Depressed mood | 19.20 | 9.89 | 254 | 263367 | 40758 | 64194353 |
Affect lability | 18.99 | 9.89 | 80 | 263541 | 8910 | 64226201 |
Purging | 18.97 | 9.89 | 7 | 263614 | 36 | 64235075 |
Cutaneous T-cell dyscrasia | 18.93 | 9.89 | 8 | 263613 | 62 | 64235049 |
Feeling of despair | 18.87 | 9.89 | 36 | 263585 | 2532 | 64232579 |
Acute myocardial infarction | 18.79 | 9.89 | 188 | 263433 | 69530 | 64165581 |
Partner stress | 18.69 | 9.89 | 13 | 263608 | 293 | 64234818 |
Tonic clonic movements | 18.62 | 9.89 | 31 | 263590 | 1958 | 64233153 |
Accident | 18.62 | 9.89 | 66 | 263555 | 6780 | 64228331 |
Mouth ulceration | 18.54 | 9.89 | 69 | 263552 | 32375 | 64202736 |
Metastases to lung | 18.53 | 9.89 | 21 | 263600 | 15243 | 64219868 |
Bipolar I disorder | 18.49 | 9.89 | 29 | 263592 | 1742 | 64233369 |
Second primary malignancy | 18.49 | 9.89 | 14 | 263607 | 12323 | 64222788 |
Hypocalcaemia | 18.31 | 9.89 | 98 | 263523 | 41655 | 64193456 |
Compartment syndrome | 18.29 | 9.89 | 48 | 263573 | 4184 | 64230927 |
Analgesic drug level increased | 18.15 | 9.89 | 33 | 263588 | 2237 | 64232874 |
Dermatitis allergic | 18.11 | 9.89 | 21 | 263600 | 15088 | 64220023 |
Abdominal pain | 17.98 | 9.89 | 1069 | 262552 | 311306 | 63923805 |
Grip strength decreased | 17.96 | 9.89 | 13 | 263608 | 11711 | 64223400 |
Brachial plexus injury | 17.89 | 9.89 | 9 | 263612 | 108 | 64235003 |
Prothrombin level decreased | 17.88 | 9.89 | 26 | 263595 | 1460 | 64233651 |
Cholangitis | 17.87 | 9.89 | 11 | 263610 | 10791 | 64224320 |
Self-injurious ideation | 17.82 | 9.89 | 40 | 263581 | 3157 | 64231954 |
Arthritis bacterial | 17.75 | 9.89 | 5 | 263616 | 7834 | 64227277 |
Necrosis ischaemic | 17.75 | 9.89 | 21 | 263600 | 962 | 64234149 |
Conversion disorder | 17.74 | 9.89 | 28 | 263593 | 1691 | 64233420 |
Blood alcohol increased | 17.72 | 9.89 | 23 | 263598 | 1159 | 64233952 |
Blood pressure diastolic increased | 17.71 | 9.89 | 11 | 263610 | 10741 | 64224370 |
COVID-19 pneumonia | 17.64 | 9.89 | 25 | 263596 | 16479 | 64218632 |
Pain | 17.62 | 9.89 | 1987 | 261634 | 551524 | 63683587 |
Feeling of relaxation | 17.47 | 9.89 | 9 | 263612 | 114 | 64234997 |
Myocardial infarction | 17.46 | 9.89 | 530 | 263091 | 165291 | 64069820 |
Drug interaction | 17.42 | 9.89 | 1712 | 261909 | 360371 | 63874740 |
Ulcer | 17.36 | 9.89 | 43 | 263578 | 22947 | 64212164 |
Puncture site haematoma | 17.31 | 9.89 | 10 | 263611 | 161 | 64234950 |
Multiple-drug resistance | 17.03 | 9.89 | 3 | 263618 | 6499 | 64228612 |
Multiple sclerosis | 16.94 | 9.89 | 134 | 263487 | 18807 | 64216304 |
Subarachnoid haemorrhage | 16.83 | 9.89 | 31 | 263590 | 18407 | 64216704 |
Hyperthermia | 16.76 | 9.89 | 115 | 263506 | 15435 | 64219676 |
Foot deformity | 16.67 | 9.89 | 26 | 263595 | 16478 | 64218633 |
Body temperature increased | 16.67 | 9.89 | 85 | 263536 | 36581 | 64198530 |
Sarcomatoid carcinoma | 16.56 | 9.89 | 6 | 263615 | 29 | 64235082 |
Cystitis haemorrhagic | 16.38 | 9.89 | 6 | 263615 | 7950 | 64227161 |
Sputum discoloured | 16.32 | 9.89 | 30 | 263591 | 17826 | 64217285 |
Poor venous access | 16.28 | 9.89 | 16 | 263605 | 12401 | 64222710 |
Anamnestic reaction | 16.24 | 9.89 | 6 | 263615 | 31 | 64235080 |
Acute graft versus host disease in skin | 16.23 | 9.89 | 4 | 263617 | 6851 | 64228260 |
Therapy partial responder | 16.18 | 9.89 | 11 | 263610 | 10237 | 64224874 |
Bladder dilatation | 16.17 | 9.89 | 28 | 263593 | 1826 | 64233285 |
Osteonecrosis | 16.15 | 9.89 | 60 | 263561 | 28169 | 64206942 |
Somnambulism | 16.13 | 9.89 | 52 | 263569 | 5089 | 64230022 |
Tendonitis | 16.05 | 9.89 | 37 | 263584 | 20245 | 64214866 |
Rhinorrhoea | 16.04 | 9.89 | 162 | 263459 | 59807 | 64175304 |
Influenza | 15.98 | 9.89 | 323 | 263298 | 106208 | 64128903 |
Bacterial prostatitis | 15.96 | 9.89 | 7 | 263614 | 60 | 64235051 |
Hypervigilance | 15.94 | 9.89 | 14 | 263607 | 448 | 64234663 |
Hypersensitivity vasculitis | 15.90 | 9.89 | 4 | 263617 | 6757 | 64228354 |
Learning disorder | 15.81 | 9.89 | 15 | 263606 | 531 | 64234580 |
Cardiac valve disease | 15.81 | 9.89 | 52 | 263569 | 5143 | 64229968 |
Papillary muscle disorder | 15.79 | 9.89 | 4 | 263617 | 3 | 64235108 |
LDL/HDL ratio increased | 15.79 | 9.89 | 4 | 263617 | 3 | 64235108 |
Pulmonary tuberculosis | 15.72 | 9.89 | 5 | 263616 | 7239 | 64227872 |
Graft versus host disease | 15.71 | 9.89 | 20 | 263601 | 13793 | 64221318 |
Neuropathy peripheral | 15.70 | 9.89 | 363 | 263258 | 117162 | 64117949 |
Device related infection | 15.69 | 9.89 | 68 | 263553 | 30558 | 64204553 |
Morbid thoughts | 15.64 | 9.89 | 17 | 263604 | 709 | 64234402 |
Jaundice | 15.62 | 9.89 | 125 | 263496 | 48387 | 64186724 |
Substance use | 15.59 | 9.89 | 16 | 263605 | 624 | 64234487 |
Incoherent | 15.55 | 9.89 | 64 | 263557 | 7054 | 64228057 |
Angina pectoris | 15.53 | 9.89 | 114 | 263507 | 44967 | 64190144 |
Muscle spasms | 15.51 | 9.89 | 715 | 262906 | 140308 | 64094803 |
Hyperreflexia | 15.41 | 9.89 | 64 | 263557 | 7084 | 64228027 |
Hypercalcaemia | 15.34 | 9.89 | 71 | 263550 | 31345 | 64203766 |
Pulmonary oedema | 15.12 | 9.89 | 425 | 263196 | 78249 | 64156862 |
Pregnancy | 15.00 | 9.89 | 40 | 263581 | 20825 | 64214286 |
Drug screen negative | 14.97 | 9.89 | 11 | 263610 | 271 | 64234840 |
Dyssomnia | 14.97 | 9.89 | 6 | 263615 | 40 | 64235071 |
Cytokine release syndrome | 14.92 | 9.89 | 40 | 263581 | 20789 | 64214322 |
Fear of injection | 14.91 | 9.89 | 3 | 263618 | 5909 | 64229202 |
Drug tolerance decreased | 14.88 | 9.89 | 5 | 263616 | 6993 | 64228118 |
Uveitis | 14.87 | 9.89 | 18 | 263603 | 12690 | 64222421 |
Tarsal tunnel syndrome | 14.87 | 9.89 | 14 | 263607 | 491 | 64234620 |
Victim of crime | 14.85 | 9.89 | 13 | 263608 | 414 | 64234697 |
Squamous cell carcinoma of skin | 14.79 | 9.89 | 16 | 263605 | 11860 | 64223251 |
Throat irritation | 14.78 | 9.89 | 76 | 263545 | 32635 | 64202476 |
BK virus infection | 14.58 | 9.89 | 6 | 263615 | 7406 | 64227705 |
Needle issue | 14.58 | 9.89 | 10 | 263611 | 9262 | 64225849 |
Epistaxis | 14.58 | 9.89 | 298 | 263323 | 97833 | 64137278 |
Logorrhoea | 14.54 | 9.89 | 43 | 263578 | 4016 | 64231095 |
Restlessness | 14.53 | 9.89 | 236 | 263385 | 39549 | 64195562 |
Alanine aminotransferase abnormal | 14.51 | 9.89 | 5 | 263616 | 6883 | 64228228 |
Brain oedema | 14.50 | 9.89 | 146 | 263475 | 21929 | 64213182 |
Lip swelling | 14.49 | 9.89 | 74 | 263547 | 31833 | 64203278 |
Cerebral congestion | 14.48 | 9.89 | 6 | 263615 | 44 | 64235067 |
Gambling disorder | 14.47 | 9.89 | 27 | 263594 | 1867 | 64233244 |
Intrusive thoughts | 14.45 | 9.89 | 12 | 263609 | 355 | 64234756 |
Blood parathyroid hormone decreased | 14.43 | 9.89 | 6 | 263615 | 7360 | 64227751 |
Cataract | 14.33 | 9.89 | 137 | 263484 | 51125 | 64183986 |
Blood triglycerides decreased | 14.27 | 9.89 | 9 | 263612 | 171 | 64234940 |
Cerebral microangiopathy | 14.20 | 9.89 | 10 | 263611 | 230 | 64234881 |
Sleep disorder due to a general medical condition | 14.16 | 9.89 | 8 | 263613 | 8226 | 64226885 |
Alcohol withdrawal syndrome | 14.15 | 9.89 | 26 | 263595 | 1777 | 64233334 |
Self esteem decreased | 13.99 | 9.89 | 18 | 263603 | 899 | 64234212 |
Immunosuppression | 13.92 | 9.89 | 14 | 263607 | 10732 | 64224379 |
Hyperkalaemia | 13.89 | 9.89 | 311 | 263310 | 100818 | 64134293 |
Drug diversion | 13.85 | 9.89 | 20 | 263601 | 1116 | 64233995 |
Gamma-glutamyltransferase increased | 13.83 | 9.89 | 129 | 263492 | 48381 | 64186730 |
Electrocardiogram QRS complex shortened | 13.79 | 9.89 | 15 | 263606 | 626 | 64234485 |
Blood pressure increased | 13.71 | 9.89 | 571 | 263050 | 171981 | 64063130 |
Localised infection | 13.67 | 9.89 | 70 | 263551 | 30091 | 64205020 |
Amimia | 13.53 | 9.89 | 6 | 263615 | 53 | 64235058 |
Haemorrhage intracranial | 13.51 | 9.89 | 51 | 263570 | 23833 | 64211278 |
Colitis | 13.51 | 9.89 | 164 | 263457 | 58510 | 64176601 |
Encephalitis | 13.48 | 9.89 | 19 | 263602 | 12552 | 64222559 |
Pulmonary alveolar haemorrhage | 13.42 | 9.89 | 12 | 263609 | 9726 | 64225385 |
Panniculitis | 13.40 | 9.89 | 10 | 263611 | 8869 | 64226242 |
Bipolar disorder | 13.39 | 9.89 | 59 | 263562 | 6702 | 64228409 |
Ligament sprain | 13.37 | 9.89 | 83 | 263538 | 10769 | 64224342 |
Cognitive disorder | 13.36 | 9.89 | 307 | 263314 | 54780 | 64180331 |
Brain death | 13.34 | 9.89 | 47 | 263574 | 4814 | 64230297 |
Hyperinsulinism | 13.34 | 9.89 | 4 | 263617 | 9 | 64235102 |
Aplasia pure red cell | 13.29 | 9.89 | 6 | 263615 | 7008 | 64228103 |
Catatonia | 13.24 | 9.89 | 64 | 263557 | 7556 | 64227555 |
Judgement impaired | 13.24 | 9.89 | 19 | 263602 | 1054 | 64234057 |
Coma scale | 13.24 | 9.89 | 6 | 263615 | 56 | 64235055 |
Lupus-like syndrome | 13.14 | 9.89 | 10 | 263611 | 8781 | 64226330 |
Appendicitis | 13.12 | 9.89 | 22 | 263599 | 13547 | 64221564 |
Refusal of treatment by patient | 13.05 | 9.89 | 68 | 263553 | 8271 | 64226840 |
Blood pressure decreased | 13.03 | 9.89 | 261 | 263360 | 85938 | 64149173 |
Palmar-plantar erythrodysaesthesia syndrome | 12.99 | 9.89 | 67 | 263554 | 28752 | 64206359 |
Joint stiffness | 12.98 | 9.89 | 72 | 263549 | 30332 | 64204779 |
Wrong rate | 12.97 | 9.89 | 6 | 263615 | 59 | 64235052 |
Hair texture abnormal | 12.91 | 9.89 | 34 | 263587 | 2970 | 64232141 |
Graft versus host disease in skin | 12.90 | 9.89 | 3 | 263618 | 5344 | 64229767 |
Oedematous pancreatitis | 12.88 | 9.89 | 17 | 263604 | 871 | 64234240 |
Meningioma | 12.85 | 9.89 | 40 | 263581 | 3842 | 64231269 |
Cystitis | 12.82 | 9.89 | 112 | 263509 | 42563 | 64192548 |
Myocarditis | 12.77 | 9.89 | 32 | 263589 | 17011 | 64218100 |
Osteoarthritis | 12.76 | 9.89 | 182 | 263439 | 63154 | 64171957 |
Formication | 12.72 | 9.89 | 43 | 263578 | 4314 | 64230797 |
Tubulointerstitial nephritis and uveitis syndrome | 12.70 | 9.89 | 10 | 263611 | 274 | 64234837 |
Product substitution issue | 12.65 | 9.89 | 120 | 263501 | 17741 | 64217370 |
Product complaint | 12.64 | 9.89 | 88 | 263533 | 11866 | 64223245 |
Myopathy | 12.63 | 9.89 | 34 | 263587 | 17646 | 64217465 |
Abnormal dreams | 12.63 | 9.89 | 79 | 263542 | 10277 | 64224834 |
Blood creatine phosphokinase | 12.61 | 9.89 | 7 | 263614 | 104 | 64235007 |
Large intestine perforation | 12.59 | 9.89 | 20 | 263601 | 12584 | 64222527 |
Aspartate aminotransferase increased | 12.58 | 9.89 | 383 | 263238 | 119405 | 64115706 |
Haematemesis | 12.55 | 9.89 | 127 | 263494 | 46872 | 64188239 |
Peritonitis | 12.55 | 9.89 | 56 | 263565 | 24967 | 64210144 |
Haemolysis | 12.53 | 9.89 | 16 | 263605 | 11023 | 64224088 |
Device malfunction | 12.53 | 9.89 | 34 | 263587 | 17599 | 64217512 |
Neoplasm progression | 12.53 | 9.89 | 107 | 263514 | 40857 | 64194254 |
Mental status changes | 12.48 | 9.89 | 333 | 263288 | 60829 | 64174282 |
Pneumatosis intestinalis | 12.48 | 9.89 | 3 | 263618 | 5226 | 64229885 |
Pulmonary toxicity | 12.47 | 9.89 | 10 | 263611 | 8551 | 64226560 |
Leukoencephalopathy | 12.46 | 9.89 | 59 | 263562 | 6908 | 64228203 |
Hyponatraemia | 12.43 | 9.89 | 733 | 262888 | 147606 | 64087505 |
Hypothermia | 12.41 | 9.89 | 130 | 263491 | 19726 | 64215385 |
Incision site pain | 12.40 | 9.89 | 31 | 263590 | 2623 | 64232488 |
Musculoskeletal disorder | 12.37 | 9.89 | 35 | 263586 | 17871 | 64217240 |
Therapeutic response shortened | 12.33 | 9.89 | 14 | 263607 | 10156 | 64224955 |
Pneumonia bacterial | 12.25 | 9.89 | 27 | 263594 | 15008 | 64220103 |
Hypercapnia | 12.22 | 9.89 | 63 | 263558 | 7631 | 64227480 |
Cushingoid | 12.22 | 9.89 | 8 | 263613 | 7595 | 64227516 |
Urinary tract infection | 12.20 | 9.89 | 799 | 262822 | 230797 | 64004314 |
Polyarthritis | 12.19 | 9.89 | 13 | 263608 | 9702 | 64225409 |
Proteinuria | 12.19 | 9.89 | 65 | 263556 | 27658 | 64207453 |
Cytomegalovirus test positive | 12.18 | 9.89 | 3 | 263618 | 5141 | 64229970 |
Substance-induced mood disorder | 12.15 | 9.89 | 7 | 263614 | 112 | 64234999 |
Chloasma | 12.15 | 9.89 | 5 | 263616 | 36 | 64235075 |
Burning sensation | 12.11 | 9.89 | 277 | 263344 | 49387 | 64185724 |
Pulmonary fibrosis | 12.08 | 9.89 | 72 | 263549 | 29806 | 64205305 |
Legal problem | 12.07 | 9.89 | 8 | 263613 | 166 | 64234945 |
Vestibular disorder | 12.02 | 9.89 | 28 | 263593 | 2265 | 64232846 |
Red blood cell count decreased | 12.01 | 9.89 | 133 | 263488 | 48253 | 64186858 |
Panic reaction | 11.98 | 9.89 | 40 | 263581 | 3987 | 64231124 |
Osteoporosis | 11.96 | 9.89 | 112 | 263509 | 41968 | 64193143 |
Cardiac failure congestive | 11.93 | 9.89 | 425 | 263196 | 130155 | 64104956 |
International normalised ratio increased | 11.88 | 9.89 | 240 | 263381 | 78927 | 64156184 |
Blastocystis infection | 11.85 | 9.89 | 4 | 263617 | 15 | 64235096 |
Transfusion | 11.83 | 9.89 | 36 | 263585 | 17958 | 64217153 |
Peripheral nerve paresis | 11.81 | 9.89 | 5 | 263616 | 39 | 64235072 |
Nephrotic syndrome | 11.79 | 9.89 | 13 | 263608 | 9554 | 64225557 |
Eosinophil count increased | 11.78 | 9.89 | 25 | 263596 | 14087 | 64221024 |
Physical assault | 11.76 | 9.89 | 22 | 263599 | 1524 | 64233587 |
Initial insomnia | 11.76 | 9.89 | 51 | 263570 | 5753 | 64229358 |
Chronic fatigue syndrome | 11.70 | 9.89 | 19 | 263602 | 1176 | 64233935 |
Pneumoconiosis | 11.67 | 9.89 | 9 | 263612 | 239 | 64234872 |
Nodular rash | 11.65 | 9.89 | 10 | 263611 | 310 | 64234801 |
Foreign body | 11.63 | 9.89 | 29 | 263592 | 2450 | 64232661 |
Infective pulmonary exacerbation of cystic fibrosis | 11.52 | 9.89 | 19 | 263602 | 11777 | 64223334 |
Staphylococcal sepsis | 11.50 | 9.89 | 22 | 263599 | 12877 | 64222234 |
Benign mesenteric neoplasm | 11.45 | 9.89 | 3 | 263618 | 3 | 64235108 |
Cutaneous lymphoma | 11.45 | 9.89 | 9 | 263612 | 246 | 64234865 |
Osteomyelitis | 11.41 | 9.89 | 66 | 263555 | 27521 | 64207590 |
Vascular headache | 11.39 | 9.89 | 5 | 263616 | 43 | 64235068 |
Loss of personal independence in daily activities | 11.37 | 9.89 | 218 | 263403 | 72236 | 64162875 |
Product quality issue | 11.34 | 9.89 | 178 | 263443 | 29621 | 64205490 |
Disinhibition | 11.33 | 9.89 | 27 | 263594 | 2216 | 64232895 |
Suspiciousness | 11.30 | 9.89 | 13 | 263608 | 578 | 64234533 |
Reduced facial expression | 11.29 | 9.89 | 26 | 263595 | 2087 | 64233024 |
Femoral artery aneurysm | 11.29 | 9.89 | 8 | 263613 | 186 | 64234925 |
Periorbital haematoma | 11.26 | 9.89 | 16 | 263605 | 880 | 64234231 |
Face injury | 11.23 | 9.89 | 33 | 263588 | 3072 | 64232039 |
Foaming at mouth | 11.21 | 9.89 | 23 | 263598 | 1706 | 64233405 |
Product substitution | 11.18 | 9.89 | 6 | 263615 | 83 | 64235028 |
Photophobia | 11.18 | 9.89 | 114 | 263507 | 17179 | 64217932 |
Rash erythematous | 11.17 | 9.89 | 136 | 263485 | 48497 | 64186614 |
Paranoia | 11.15 | 9.89 | 109 | 263512 | 16243 | 64218868 |
Alcoholism | 11.12 | 9.89 | 35 | 263586 | 3382 | 64231729 |
Faeces soft | 11.10 | 9.89 | 5 | 263616 | 5850 | 64229261 |
Haematuria | 11.07 | 9.89 | 177 | 263444 | 60294 | 64174817 |
Post-traumatic stress disorder | 10.98 | 9.89 | 40 | 263581 | 4165 | 64230946 |
Inflammatory marker increased | 10.96 | 9.89 | 11 | 263610 | 8440 | 64226671 |
Sudden death | 10.93 | 9.89 | 128 | 263493 | 19968 | 64215143 |
Creatinine renal clearance decreased | 10.87 | 9.89 | 27 | 263594 | 14394 | 64220717 |
Cholestasis | 10.86 | 9.89 | 250 | 263371 | 44622 | 64190489 |
Multiple sclerosis relapse | 10.84 | 9.89 | 232 | 263389 | 40903 | 64194208 |
Hypoventilation | 10.84 | 9.89 | 51 | 263570 | 5955 | 64229156 |
Electroencephalogram abnormal | 10.76 | 9.89 | 46 | 263575 | 5157 | 64229954 |
Myoclonus | 10.71 | 9.89 | 153 | 263468 | 24965 | 64210146 |
Skin necrosis | 10.66 | 9.89 | 27 | 263594 | 14302 | 64220809 |
Death of relative | 10.62 | 9.89 | 8 | 263613 | 205 | 64234906 |
Cyclothymic disorder | 10.62 | 9.89 | 8 | 263613 | 205 | 64234906 |
Myositis | 10.60 | 9.89 | 33 | 263588 | 16344 | 64218767 |
Central nervous system necrosis | 10.59 | 9.89 | 9 | 263612 | 275 | 64234836 |
Skin toxicity | 10.54 | 9.89 | 7 | 263614 | 6595 | 64228516 |
Apraxia | 10.48 | 9.89 | 28 | 263593 | 2467 | 64232644 |
Thrombotic microangiopathy | 10.47 | 9.89 | 34 | 263587 | 16621 | 64218490 |
Food allergy | 10.43 | 9.89 | 10 | 263611 | 7841 | 64227270 |
Enterococcal infection | 10.42 | 9.89 | 26 | 263595 | 13840 | 64221271 |
Frequent bowel movements | 10.41 | 9.89 | 39 | 263582 | 18266 | 64216845 |
Tumour hyperprogression | 10.37 | 9.89 | 7 | 263614 | 150 | 64234961 |
Biliary dyskinesia | 10.35 | 9.89 | 27 | 263594 | 2345 | 64232766 |
Pneumonia viral | 10.35 | 9.89 | 10 | 263611 | 7812 | 64227299 |
Wound infection | 10.31 | 9.89 | 29 | 263592 | 14835 | 64220276 |
Gallbladder hypofunction | 10.27 | 9.89 | 11 | 263610 | 451 | 64234660 |
Progressive multifocal leukoencephalopathy | 10.27 | 9.89 | 39 | 263582 | 18193 | 64216918 |
Accidental poisoning | 10.22 | 9.89 | 20 | 263601 | 1433 | 64233678 |
Fistula | 10.22 | 9.89 | 15 | 263606 | 9746 | 64225365 |
Injection site pruritus | 10.19 | 9.89 | 102 | 263519 | 37724 | 64197387 |
Hypophagia | 10.15 | 9.89 | 108 | 263513 | 39479 | 64195632 |
Myotonia | 10.13 | 9.89 | 8 | 263613 | 220 | 64234891 |
Skin plaque | 10.11 | 9.89 | 13 | 263608 | 8927 | 64226184 |
Nephrolithiasis | 10.09 | 9.89 | 122 | 263499 | 43561 | 64191550 |
Phobia | 10.09 | 9.89 | 10 | 263611 | 374 | 64234737 |
Metastases to bone | 10.09 | 9.89 | 46 | 263575 | 20389 | 64214722 |
Dysuria | 10.08 | 9.89 | 234 | 263387 | 41823 | 64193288 |
Torsade de pointes | 10.07 | 9.89 | 112 | 263509 | 17251 | 64217860 |
Respiratory tract infection | 10.02 | 9.89 | 101 | 263520 | 37306 | 64197805 |
Immune thrombocytopenia | 10.01 | 9.89 | 30 | 263591 | 15036 | 64220075 |
Conjunctivitis | 9.94 | 9.89 | 46 | 263575 | 20308 | 64214803 |
Blood lactic acid increased | 9.93 | 9.89 | 17 | 263604 | 10384 | 64224727 |
Laparoscopy | 9.93 | 9.89 | 3 | 263618 | 7 | 64235104 |
None
Source | Code | Description |
---|---|---|
ATC | N05BA12 | NERVOUS SYSTEM PSYCHOLEPTICS ANXIOLYTICS Benzodiazepine derivatives |
FDA CS | M0002356 | Benzodiazepines |
CHEBI has role | CHEBI:35474 | anti-anxiety agents |
CHEBI has role | CHEBI:35623 | anticonvulsants |
CHEBI has role | CHEBI:35703 | Xenobiotic |
CHEBI has role | CHEBI:35717 | hypnotics |
CHEBI has role | CHEBI:51371 | muscle relaxants |
CHEBI has role | CHEBI:51373 | gamma-aminobutyric acid receptor agonist |
MeSH PA | D014151 | Anti-Anxiety Agents |
MeSH PA | D002491 | Central Nervous System Agents |
MeSH PA | D002492 | Central Nervous System Depressants |
MeSH PA | D018682 | GABA Agents |
MeSH PA | D018757 | GABA Modulators |
MeSH PA | D006993 | Hypnotics and Sedatives |
MeSH PA | D018377 | Neurotransmitter Agents |
MeSH PA | D011619 | Psychotropic Drugs |
MeSH PA | D014149 | Tranquilizing Agents |
FDA EPC | N0000175694 | Benzodiazepine |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Generalized anxiety disorder | indication | 21897009 | DOID:14320 |
Anxiety | indication | 48694002 | |
Mixed anxiety and depressive disorder | indication | 231504006 | |
Panic disorder | indication | 371631005 | DOID:594 |
Insomnia | off-label use | 193462001 | |
Suicidal thoughts | contraindication | 6471006 | |
Asthenia | contraindication | 13791008 | |
Alcohol intoxication | contraindication | 25702006 | |
Depressive disorder | contraindication | 35489007 | |
Substance abuse | contraindication | 66214007 | |
Sleep apnea | contraindication | 73430006 | DOID:0050847 |
Open-angle glaucoma | contraindication | 84494001 | DOID:1067 |
Kidney disease | contraindication | 90708001 | DOID:557 |
Disease of liver | contraindication | 235856003 | DOID:409 |
Syncope | contraindication | 271594007 | |
Pregnancy, function | contraindication | 289908002 | |
Angle-closure glaucoma | contraindication | 392291006 | DOID:13550 |
Breastfeeding (mother) | contraindication | 413712001 | |
Chronic lung disease | contraindication | 413839001 | |
Obesity | contraindication | 414916001 | DOID:9970 |
Central nervous system depression | contraindication | 418072004 | |
Smokes tobacco daily | contraindication | 449868002 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 6.15 | Basic |
pKa2 | 4.9 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
GABA-A receptor alpha-5/beta-3/gamma-2 | Ion channel | POSITIVE ALLOSTERIC MODULATOR | EC50 | 8 | WOMBAT-PK | CHEMBL | |||
GABA-A receptor alpha-1/beta-2/gamma-2 | Ion channel | POSITIVE ALLOSTERIC MODULATOR | EC50 | 7.43 | WOMBAT-PK | CHEMBL | |||
GABA-A receptor alpha-2/beta-3/gamma-2 | Ion channel | POSITIVE ALLOSTERIC MODULATOR | EC50 | 7.92 | WOMBAT-PK | CHEMBL | |||
GABA-A receptor alpha-3/beta-3/gamma-2 | Ion channel | POSITIVE ALLOSTERIC MODULATOR | EC50 | 7.16 | WOMBAT-PK | CHEMBL | |||
Cytochrome P450 3A4 | Enzyme | Ki | 3.85 | WOMBAT-PK | |||||
Platelet-activating factor receptor | GPCR | Ki | 5.46 | PDSP | |||||
Bromodomain-containing protein 4 | Unclassified | Kd | 5.61 | CHEMBL | |||||
Cholecystokinin receptor type A | GPCR | IC50 | 4.19 | CHEMBL |
ID | Source |
---|---|
D00225 | KEGG_DRUG |
202363 | RXNORM |
C0002333 | UMLSCUI |
CHEBI:2611 | CHEBI |
08H | PDB_CHEM_ID |
CHEMBL661 | ChEMBL_ID |
DB00404 | DRUGBANK_ID |
D000525 | MESH_DESCRIPTOR_UI |
2118 | PUBCHEM_CID |
7111 | IUPHAR_LIGAND_ID |
3426 | INN_ID |
YU55MQ3IZY | UNII |
1327 | MMSL |
1885 | MMSL |
4153 | MMSL |
d00168 | MMSL |
001464 | NDDF |
4018074 | VANDF |
111127002 | SNOMEDCT_US |
386983007 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Xanax | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0009-0029 | TABLET | 0.25 mg | ORAL | NDA | 36 sections |
Xanax | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0009-0055 | TABLET | 0.50 mg | ORAL | NDA | 36 sections |
Xanax XR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0009-0057 | TABLET, EXTENDED RELEASE | 0.50 mg | ORAL | NDA | 37 sections |
Xanax XR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0009-0057 | TABLET, EXTENDED RELEASE | 0.50 mg | ORAL | NDA | 37 sections |
Xanax XR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0009-0059 | TABLET, EXTENDED RELEASE | 1 mg | ORAL | NDA | 37 sections |
Xanax XR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0009-0059 | TABLET, EXTENDED RELEASE | 1 mg | ORAL | NDA | 37 sections |
Xanax XR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0009-0066 | TABLET, EXTENDED RELEASE | 2 mg | ORAL | NDA | 37 sections |
Xanax XR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0009-0066 | TABLET, EXTENDED RELEASE | 2 mg | ORAL | NDA | 37 sections |
Xanax XR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0009-0068 | TABLET, EXTENDED RELEASE | 3 mg | ORAL | NDA | 37 sections |
Xanax XR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0009-0068 | TABLET, EXTENDED RELEASE | 3 mg | ORAL | NDA | 37 sections |
Xanax | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0009-0090 | TABLET | 1 mg | ORAL | NDA | 36 sections |
Xanax | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0009-0094 | TABLET | 2 mg | ORAL | NDA | 36 sections |
Alprazolam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-3068 | SOLUTION, CONCENTRATE | 1 mg | ORAL | ANDA | 16 sections |
Alprazolam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0228-2027 | TABLET | 0.25 mg | ORAL | ANDA | 29 sections |
Alprazolam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0228-2027 | TABLET | 0.25 mg | ORAL | ANDA | 29 sections |
Alprazolam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0228-2029 | TABLET | 0.50 mg | ORAL | ANDA | 29 sections |
Alprazolam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0228-2029 | TABLET | 0.50 mg | ORAL | ANDA | 29 sections |
Alprazolam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0228-2031 | TABLET | 1 mg | ORAL | ANDA | 29 sections |
Alprazolam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0228-2031 | TABLET | 1 mg | ORAL | ANDA | 29 sections |
Alprazolam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0228-2039 | TABLET | 2 mg | ORAL | ANDA | 29 sections |
Alprazolam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0228-2039 | TABLET | 2 mg | ORAL | ANDA | 29 sections |
AlprazolamExtended Release | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0228-3083 | TABLET, EXTENDED RELEASE | 0.50 mg | ORAL | ANDA | 29 sections |
AlprazolamExtended Release | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0228-3084 | TABLET, EXTENDED RELEASE | 1 mg | ORAL | ANDA | 29 sections |
AlprazolamExtended Release | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0228-3086 | TABLET, EXTENDED RELEASE | 3 mg | ORAL | ANDA | 29 sections |
AlprazolamExtended Release | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0228-3087 | TABLET, EXTENDED RELEASE | 2 mg | ORAL | ANDA | 29 sections |
Alprazolam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0228-4019 | TABLET, ORALLY DISINTEGRATING | 0.25 mg | ORAL | ANDA | 31 sections |
Alprazolam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0228-4022 | TABLET, ORALLY DISINTEGRATING | 0.50 mg | ORAL | ANDA | 31 sections |
Alprazolam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0228-4024 | TABLET, ORALLY DISINTEGRATING | 1 mg | ORAL | ANDA | 31 sections |
Alprazolam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0228-4025 | TABLET, ORALLY DISINTEGRATING | 2 mg | ORAL | ANDA | 31 sections |
Alprazolam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8215 | TABLET | 0.25 mg | ORAL | ANDA | 29 sections |