alprazolam 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
diazepam derivatives 136 28981-97-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • xanax
  • alprazolam
  • alprozolam
  • alzolam
A triazolobenzodiazepine compound with antianxiety and sedative-hypnotic actions, that is efficacious in the treatment of PANIC DISORDERS, with or without AGORAPHOBIA, and in generalized ANXIETY DISORDERS. (From AMA Drug Evaluations Annual, 1994, p238)
  • Molecular weight: 308.77
  • Formula: C17H13ClN4
  • CLOGP: 2.56
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 0
  • TPSA: 43.07
  • ALOGS: -3.98
  • ROTB: 1
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
1 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.07 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 20 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.46 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 88 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.80 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 0.74 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.29 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 12 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Oct. 16, 1981 FDA PHARMACIA AND UPJOHN

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug abuse 5867.10 9.71 3586 241084 68932 63175420
Completed suicide 4349.58 9.71 3954 240716 141719 63102633
Sopor 2268.01 9.71 1278 243392 20886 63223466
Toxicity to various agents 2023.89 9.71 3503 241167 243747 63000605
Respiratory arrest 1367.50 9.71 1079 243591 31566 63212786
Suicide attempt 1248.85 9.71 1350 243320 59568 63184784
Poisoning 1157.73 9.71 698 243972 13002 63231350
Intentional overdose 1116.19 9.71 1402 243268 72750 63171602
Cardio-respiratory arrest 975.34 9.71 1179 243491 58780 63185572
Poisoning deliberate 895.15 9.71 551 244119 10667 63233685
Coma 889.98 9.71 1167 243503 63197 63181155
Cardiac arrest 843.36 9.71 1378 243292 91167 63153185
Drug dependence 713.01 9.71 657 244013 23826 63220526
Overdose 696.75 9.71 1436 243234 113642 63130710
Pemphigus 689.66 9.71 3 244667 183723 63060629
Somnolence 575.02 9.71 1752 242918 176933 63067419
Hand deformity 552.12 9.71 13 244657 159444 63084908
Contraindicated product administered 542.36 9.71 93 244577 217555 63026797
Synovitis 524.76 9.71 55 244615 186863 63057489
Systemic lupus erythematosus 523.37 9.71 88 244582 208830 63035522
Intentional product misuse 486.97 9.71 856 243814 60061 63184291
Intentional self-injury 480.62 9.71 543 244127 25144 63219208
Glossodynia 460.02 9.71 70 244600 178806 63065546
Anti-cyclic citrullinated peptide antibody positive 425.38 9.71 4 244666 116208 63128144
Drug intolerance 422.68 9.71 342 244328 308319 62936033
Pericarditis 407.30 9.71 25 244645 131554 63112798
Arthropathy 405.47 9.71 199 244471 234593 63009759
Joint swelling 388.54 9.71 414 244256 327252 62917100
Treatment failure 369.79 9.71 152 244518 198891 63045461
Maternal exposure during pregnancy 362.90 9.71 198 244472 219864 63024488
Alopecia 337.67 9.71 486 244184 337050 62907302
Lower respiratory tract infection 335.06 9.71 54 244616 132253 63112099
Drug ineffective 323.06 9.71 2535 242135 1042230 62202122
Off label use 321.18 9.71 1424 243246 673038 62571314
Swelling 318.51 9.71 355 244315 275023 62969329
Bradyphrenia 310.06 9.71 239 244431 6741 63237611
Helicobacter infection 301.73 9.71 13 244657 92772 63151580
Rheumatoid arthritis 295.93 9.71 325 244345 253494 62990858
Anxiety 287.44 9.71 1621 243049 215920 63028432
Drug withdrawal syndrome 286.32 9.71 433 244237 26761 63217591
Infusion related reaction 285.54 9.71 315 244355 245206 62999146
Discomfort 284.11 9.71 145 244525 167229 63077123
Suicidal ideation 275.94 9.71 688 243982 61733 63182619
Wound 264.58 9.71 150 244520 163113 63081239
Abdominal discomfort 261.15 9.71 527 244143 320358 62923994
Depression 258.75 9.71 1463 243207 195029 63049323
Substance abuse 236.57 9.71 175 244495 4632 63239720
Mydriasis 229.18 9.71 256 244414 11700 63232652
Folliculitis 224.88 9.71 11 244659 70306 63174046
Therapeutic product effect decreased 220.00 9.71 252 244418 192935 63051417
Rheumatoid factor positive 214.67 9.71 34 244636 84372 63159980
Nasopharyngitis 211.56 9.71 412 244258 253845 62990507
Drug use disorder 211.27 9.71 166 244504 4818 63239534
Withdrawal syndrome 208.51 9.71 317 244353 19680 63224672
Death 206.65 9.71 2278 242392 372103 62872249
Product use issue 197.97 9.71 341 244329 220179 63024173
Panic attack 193.04 9.71 325 244345 22006 63222346
Agitation 192.80 9.71 587 244083 59170 63185182
Exposure via ingestion 192.51 9.71 127 244543 2782 63241570
Hypersensitivity 192.37 9.71 538 244132 292147 62952205
Infection 189.20 9.71 373 244297 228800 63015552
Hepatic enzyme increased 187.96 9.71 306 244364 202022 63042330
Arthralgia 185.12 9.71 1361 243309 568349 62676003
Loss of consciousness 185.10 9.71 923 243747 117198 63127154
Muscle injury 178.76 9.71 21 244649 65324 63179028
Sleep disorder due to general medical condition, insomnia type 174.23 9.71 6 244664 52211 63192141
Macular degeneration 167.49 9.71 321 244349 24055 63220297
Rash 159.47 9.71 1389 243281 559482 62684870
Peripheral swelling 157.39 9.71 513 244157 265429 62978923
Rheumatic fever 151.15 9.71 3 244667 43108 63201244
Tremor 151.06 9.71 949 243721 131290 63113062
C-reactive protein abnormal 148.06 9.71 7 244663 46089 63198263
Prescription form tampering 146.46 9.71 62 244608 516 63243836
Impaired healing 140.87 9.71 113 244557 102429 63141923
Victim of chemical submission 137.92 9.71 58 244612 474 63243878
General physical health deterioration 137.64 9.71 363 244307 201039 63043313
Blister 131.44 9.71 185 244485 129629 63114723
Irritable bowel syndrome 121.99 9.71 84 244586 82328 63162024
Musculoskeletal stiffness 120.70 9.71 340 244330 184278 63060074
Bradykinesia 120.48 9.71 123 244547 5065 63239287
Insomnia 119.50 9.71 1312 243358 213940 63030412
Altered state of consciousness 118.79 9.71 285 244385 24945 63219407
Disturbance in attention 113.80 9.71 365 244305 37824 63206528
Gastrointestinal disorder 108.74 9.71 213 244457 131026 63113326
Fall 106.60 9.71 2112 242558 390222 62854130
Depressed level of consciousness 103.57 9.71 494 244176 61584 63182768
Knee arthroplasty 102.84 9.71 40 244630 54166 63190186
Stomatitis 102.57 9.71 240 244430 138485 63105867
Hepatocellular injury 97.86 9.71 279 244391 27102 63217250
Psoriatic arthropathy 96.08 9.71 127 244543 91393 63152959
Liver injury 95.98 9.71 57 244613 60463 63183889
Ill-defined disorder 94.78 9.71 105 244565 81650 63162702
Accidental overdose 94.75 9.71 249 244421 23060 63221292
Drug screen positive 93.43 9.71 91 244579 3538 63240814
Hip arthroplasty 92.32 9.71 34 244636 47612 63196740
Suspected suicide 92.08 9.71 120 244550 6448 63237904
Feeling abnormal 91.46 9.71 924 243746 147468 63096884
Sinusitis 90.95 9.71 507 244163 226146 63018206
Miosis 90.36 9.71 126 244544 7227 63237125
Alcohol abuse 89.93 9.71 71 244599 2075 63242277
Nervousness 88.61 9.71 292 244378 30687 63213665
Crying 88.48 9.71 243 244427 23100 63221252
C-reactive protein increased 86.23 9.71 145 244525 94562 63149790
Intentional product use issue 83.21 9.71 236 244434 127656 63116696
Disorientation 82.55 9.71 336 244334 39116 63205236
Drug abuser 80.36 9.71 76 244594 2847 63241505
Mobility decreased 77.77 9.71 225 244445 120934 63123418
Hypokinesia 76.19 9.71 167 244503 13769 63230583
Drug interaction 75.61 9.71 1272 243398 227859 63016493
Memory impairment 74.55 9.71 670 244000 103588 63140764
Hallucinations, mixed 73.65 9.71 92 244578 4737 63239615
Myelosuppression 71.83 9.71 5 244665 23698 63220654
Drug hypersensitivity 70.68 9.71 811 243859 309876 62934476
Hallucination, auditory 70.48 9.71 154 244516 12670 63231682
Febrile neutropenia 70.31 9.71 228 244442 118221 63126131
Condition aggravated 70.12 9.71 1109 243561 401108 62843244
Product use in unapproved indication 69.97 9.71 404 244266 178676 63065676
Abnormal behaviour 69.57 9.71 211 244459 21215 63223137
Dependence 68.87 9.71 60 244610 2017 63242335
Wheezing 67.78 9.71 169 244501 95426 63148926
Vertigo 65.37 9.71 425 244245 59462 63184890
Irritability 64.78 9.71 268 244402 31426 63212926
Confusional state 64.56 9.71 1274 243396 235106 63009246
Aggression 63.23 9.71 217 244453 23281 63221071
Pyrexia 63.03 9.71 1358 243312 469120 62775232
Therapeutic product effect incomplete 62.83 9.71 258 244412 124798 63119554
Urinary retention 62.55 9.71 257 244413 30044 63214308
Exposure during pregnancy 62.33 9.71 348 244322 155199 63089153
Therapy non-responder 62.15 9.71 124 244546 75777 63168575
Psychomotor skills impaired 62.13 9.71 60 244610 2308 63242044
Psychomotor hyperactivity 61.99 9.71 131 244539 10532 63233820
Bradypnoea 61.26 9.71 72 244598 3478 63240874
Cough 60.92 9.71 779 243891 291964 62952388
Hyponatraemia 60.15 9.71 678 243992 111222 63133130
Live birth 59.42 9.71 13 244657 25617 63218735
Respiratory depression 59.34 9.71 150 244520 13565 63230787
Pain 59.18 9.71 2296 242374 738332 62506020
Drug resistance 58.83 9.71 9 244661 22924 63221428
Adverse drug reaction 58.82 9.71 138 244532 79576 63164776
Anhedonia 58.29 9.71 130 244540 10844 63233508
Homicide 52.82 9.71 27 244643 358 63243994
Serotonin syndrome 52.82 9.71 235 244435 28447 63215905
Euphoric mood 51.69 9.71 78 244592 4809 63239543
Mental disorder 51.28 9.71 217 244453 25702 63218650
Hyperhidrosis 50.74 9.71 637 244033 107199 63137153
Electrocardiogram QT prolonged 50.74 9.71 398 244272 59132 63185220
Emotional distress 50.68 9.71 254 244416 32295 63212057
Bone erosion 50.21 9.71 5 244665 17712 63226640
Type 2 diabetes mellitus 50.04 9.71 107 244563 63761 63180591
Blood cholesterol increased 49.76 9.71 190 244480 93842 63150510
Pneumonia 49.48 9.71 1361 243309 455406 62788946
Abnormal dreams 48.65 9.71 118 244552 10398 63233954
Hypotension 48.58 9.71 1385 243285 271219 62973133
Speech disorder 48.48 9.71 295 244375 40334 63204018
Substance use disorder 48.48 9.71 21 244649 186 63244166
Grip strength decreased 48.35 9.71 13 244657 22274 63222078
Respiratory acidosis 48.06 9.71 90 244580 6625 63237727
Wrong patient received product 47.08 9.71 50 244620 2157 63242195
Thinking abnormal 45.63 9.71 116 244554 10527 63233825
Malignant neoplasm progression 44.71 9.71 164 244506 81957 63162395
Anger 44.58 9.71 127 244543 12329 63232023
Premature delivery 43.31 9.71 32 244638 30249 63214103
Neutropenic sepsis 43.21 9.71 6 244664 16432 63227920
Mania 43.20 9.71 125 244545 12242 63232110
COVID-19 42.64 9.71 258 244412 112845 63131507
Nightmare 42.17 9.71 166 244504 19028 63225324
Thermal burn 41.99 9.71 80 244590 5966 63238386
Alcohol poisoning 41.87 9.71 44 244626 1875 63242477
Delirium 41.48 9.71 335 244335 50206 63194146
Suicidal behaviour 41.41 9.71 51 244619 2588 63241764
Dysarthria 41.18 9.71 294 244376 42417 63201935
Amnesia 41.15 9.71 360 244310 55225 63189127
Bradycardia 40.85 9.71 447 244223 72780 63171572
Fatigue 40.62 9.71 2912 241758 885116 62359236
Anticholinergic syndrome 40.59 9.71 48 244622 2334 63242018
Product complaint 40.52 9.71 125 244545 12684 63231668
Hallucination 40.05 9.71 354 244316 54463 63189889
Head injury 40.01 9.71 210 244460 27186 63217166
Blood pressure diastolic decreased 39.50 9.71 19 244651 22687 63221665
Obsessive-compulsive disorder 39.02 9.71 62 244608 3998 63240354
Dysphoria 38.63 9.71 69 244601 4897 63239455
Neutrophil count decreased 38.22 9.71 102 244568 56304 63188048
Mucosal inflammation 38.12 9.71 77 244593 46851 63197501
Hallucination, visual 37.74 9.71 161 244509 19137 63225215
Neutropenia 36.25 9.71 466 244204 174539 63069813
Rhabdomyolysis 35.90 9.71 291 244379 43660 63200692
Psychomotor retardation 35.69 9.71 58 244612 3812 63240540
Compartment syndrome 35.61 9.71 44 244626 2240 63242112
Foot deformity 35.43 9.71 33 244637 27820 63216532
Renal impairment 35.20 9.71 198 244472 88157 63156195
Cholecystitis chronic 34.54 9.71 103 244567 10258 63234094
Urticaria 34.52 9.71 441 244229 165361 63078991
Sedation 34.48 9.71 262 244408 38547 63205805
Fear 34.35 9.71 136 244534 15630 63228722
Impaired driving ability 34.23 9.71 62 244608 4449 63239903
Bronchiectasis 33.93 9.71 10 244660 16132 63228220
Housebound 33.83 9.71 17 244653 217 63244135
Multiple injuries 33.60 9.71 38 244632 1760 63242592
Blood pressure systolic increased 33.43 9.71 84 244586 47313 63197039
Dyspnoea 32.91 9.71 2152 242518 659161 62585191
Cytomegalovirus infection 32.84 9.71 20 244650 20932 63223420
Stupor 32.75 9.71 59 244611 4216 63240136
Parkinsonism 32.21 9.71 101 244569 10338 63234014
Immobilisation prolonged 31.81 9.71 13 244657 98 63244254
Feeling of despair 31.65 9.71 42 244628 2297 63242055
Osmolar gap increased 31.59 9.71 13 244657 100 63244252
Renal papillary necrosis 31.18 9.71 17 244653 259 63244093
Sluggishness 30.94 9.71 65 244605 5204 63239148
Chemical submission 30.84 9.71 17 244653 265 63244087
Persistent genital arousal disorder 30.61 9.71 17 244653 269 63244083
Osteoarthritis 30.19 9.71 229 244441 95114 63149238
Blood pressure fluctuation 29.71 9.71 86 244584 46231 63198121
Lupus-like syndrome 29.48 9.71 11 244659 15284 63229068
Seizure 29.46 9.71 694 243976 131940 63112412
Red blood cell sedimentation rate increased 29.45 9.71 80 244590 43902 63200450
Obstructive airways disorder 29.44 9.71 22 244648 20677 63223675
Adverse event 29.35 9.71 147 244523 67412 63176940
Breast cancer stage III 29.26 9.71 3 244667 10383 63233969
Panic disorder 29.24 9.71 43 244627 2590 63241762
Cholestasis 29.18 9.71 204 244466 29230 63215122
Accidental death 29.11 9.71 37 244633 1939 63242413
Inadequate analgesia 28.36 9.71 45 244625 2898 63241454
Major depression 27.97 9.71 81 244589 7937 63236415
Restlessness 27.96 9.71 202 244468 29251 63215101
Adjustment disorder with mixed anxiety and depressed mood 27.54 9.71 12 244658 108 63244244
Apraxia 26.67 9.71 34 244636 1787 63242565
Multiple sclerosis relapse 26.61 9.71 295 244375 48183 63196169
Cardiogenic shock 26.56 9.71 138 244532 17794 63226558
Pruritus 26.48 9.71 1131 243539 360322 62884030
Anaphylactic reaction 26.39 9.71 148 244522 65952 63178400
Inflammation 26.34 9.71 197 244473 82076 63162276
Sinus tachycardia 26.33 9.71 172 244498 24096 63220256
Toxicologic test abnormal 26.30 9.71 22 244648 699 63243653
Disinhibition 26.29 9.71 24 244646 859 63243493
Pregnancy 26.20 9.71 65 244605 36771 63207581
Extrapyramidal disorder 26.11 9.71 111 244559 13173 63231179
Self-injurious ideation 26.10 9.71 41 244629 2618 63241734
Mental status changes 26.03 9.71 250 244420 39349 63205003
Multiple sclerosis 26.00 9.71 172 244498 24200 63220152
Sepsis 26.00 9.71 424 244246 152699 63091653
Poverty of speech 25.88 9.71 16 244654 312 63244040
Arthritis 25.75 9.71 304 244366 115617 63128735
Inappropriate antidiuretic hormone secretion 25.74 9.71 123 244547 15339 63229013
Suspected counterfeit product 25.70 9.71 17 244653 374 63243978
Incoherent 25.58 9.71 55 244615 4475 63239877
Bipolar I disorder 25.54 9.71 34 244636 1865 63242487
Device expulsion 25.32 9.71 61 244609 34861 63209491
Unresponsive to stimuli 25.02 9.71 219 244451 33597 63210755
Stress 24.77 9.71 380 244290 66787 63177565
Post-traumatic stress disorder 24.37 9.71 59 244611 5192 63239160
Hypotonia 24.33 9.71 85 244585 9200 63235152
Wound infection 24.26 9.71 28 244642 21382 63222970
Hyponatraemic encephalopathy 24.12 9.71 14 244656 242 63244110
Depressed mood 24.12 9.71 249 244421 39942 63204410
Logorrhoea 23.67 9.71 38 244632 2472 63241880
Disease progression 23.55 9.71 332 244338 122426 63121926
Asthenia 23.55 9.71 1749 242921 381855 62862497
Cyanosis 23.49 9.71 128 244542 16807 63227545
Apathy 23.47 9.71 81 244589 8713 63235639
Drug-induced liver injury 23.45 9.71 78 244592 40144 63204208
Emotional disorder 23.42 9.71 108 244562 13271 63231081
Hypersomnia 23.41 9.71 134 244536 17921 63226431
Hypothermia 23.31 9.71 109 244561 13472 63230880
Substance use 23.31 9.71 18 244652 509 63243843
Liver function test increased 23.25 9.71 58 244612 32753 63211599
Fibromyalgia 23.23 9.71 198 244472 80222 63164130
Drug detoxification 23.20 9.71 15 244655 317 63244035
Alcohol use 23.16 9.71 34 244636 2045 63242307
Sleep disorder due to a general medical condition 23.10 9.71 9 244661 12179 63232173
Generalised tonic-clonic seizure 23.09 9.71 191 244479 28825 63215527
Necrosis ischaemic 22.96 9.71 22 244648 838 63243514
Benzodiazepine drug level abnormal 22.81 9.71 5 244665 0 63244352
Bipolar disorder 22.73 9.71 75 244595 7885 63236467
Liver disorder 22.65 9.71 118 244552 53569 63190783
Hallucination, gustatory 22.47 9.71 9 244661 64 63244288
Pancytopenia 22.39 9.71 252 244418 96681 63147671
Initial insomnia 22.25 9.71 63 244607 6094 63238258
Transplant rejection 22.08 9.71 7 244663 10773 63233579
Adjustment disorder with depressed mood 22.05 9.71 6 244664 10198 63234154
Drug withdrawal syndrome neonatal 21.70 9.71 33 244637 2048 63242304
Metastases to liver 21.68 9.71 36 244634 23603 63220749
Procedural pain 21.68 9.71 150 244520 21419 63222933
Panic reaction 21.67 9.71 49 244621 4125 63240227
Gun shot wound 21.51 9.71 11 244659 146 63244206
Drug withdrawal convulsions 21.49 9.71 27 244643 1398 63242954
Obsessive thoughts 21.49 9.71 18 244652 573 63243779
Tonic clonic movements 21.34 9.71 27 244643 1408 63242944
Somnambulism 21.30 9.71 58 244612 5485 63238867
Lip dry 21.29 9.71 17 244653 15453 63228899
Blood pressure diastolic abnormal 21.27 9.71 15 244655 14527 63229825
Joint stiffness 21.25 9.71 86 244584 41783 63202569
Affect lability 21.01 9.71 92 244578 11059 63233293
Neuroleptic malignant syndrome 20.87 9.71 97 244573 11959 63232393
Electrocardiogram QRS complex prolonged 20.72 9.71 60 244610 5878 63238474
Dysuria 20.71 9.71 210 244460 33528 63210824
Developmental delay 20.64 9.71 27 244643 1456 63242896
Pupillary disorder 20.35 9.71 12 244658 214 63244138
Joint range of motion decreased 20.23 9.71 61 244609 32367 63211985
Mood altered 20.16 9.71 111 244559 14632 63229720
Herpes zoster 19.99 9.71 212 244458 82250 63162102
Aplastic anaemia 19.98 9.71 6 244664 9563 63234789
Torsade de pointes 19.95 9.71 103 244567 13248 63231104
Tarsal tunnel syndrome 19.88 9.71 17 244653 557 63243795
Facet joint syndrome 19.86 9.71 11 244659 12127 63232225
Hyperreflexia 19.79 9.71 59 244611 5875 63238477
Body temperature increased 19.76 9.71 75 244595 37117 63207235
Prescription drug used without a prescription 19.66 9.71 34 244636 2352 63242000
Uveitis 19.65 9.71 12 244658 12541 63231811
Blood pressure diastolic increased 19.63 9.71 7 244663 10003 63234349
Tension 19.62 9.71 40 244630 3135 63241217
Delusion 19.57 9.71 95 244575 11922 63232430
Neurotoxicity 19.49 9.71 22 244648 16968 63227384
Muscle spasms 19.48 9.71 761 243909 155389 63088963
Cutaneous T-cell dyscrasia 19.39 9.71 8 244662 62 63244290
Partner stress 19.28 9.71 15 244655 429 63243923
Hypoglycaemia 19.24 9.71 332 244338 59733 63184619
Femur fracture 19.22 9.71 89 244581 41667 63202685
Ataxia 19.19 9.71 112 244558 15083 63229269
Blood lactic acid 19.16 9.71 9 244661 98 63244254
Asthma 19.16 9.71 361 244309 127200 63117152
Acquired amegakaryocytic thrombocytopenia 19.13 9.71 6 244664 18 63244334
X-ray abnormal 19.03 9.71 4 244666 8106 63236246
Cardiac failure 18.95 9.71 236 244434 88906 63155446
Peripheral venous disease 18.91 9.71 19 244651 15458 63228894
Full blood count abnormal 18.84 9.71 61 244609 31656 63212696
Substance dependence 18.81 9.71 11 244659 193 63244159
Face injury 18.71 9.71 40 244630 3242 63241110
Morbid thoughts 18.68 9.71 17 244653 606 63243746
Pain in extremity 18.65 9.71 1066 243604 330420 62913932
Leukopenia 18.62 9.71 199 244471 77091 63167261
Chronic sinusitis 18.45 9.71 98 244572 12745 63231607
Hypochloraemia 18.38 9.71 30 244640 1979 63242373
Product substitution issue 18.36 9.71 115 244555 15881 63228471
Haemophagocytic lymphohistiocytosis 18.32 9.71 9 244661 10618 63233734
Vision blurred 18.31 9.71 474 244196 91450 63152902
Persecutory delusion 18.26 9.71 36 244634 2754 63241598
Medication error 18.22 9.71 293 244377 51991 63192361
Theft 18.17 9.71 8 244662 74 63244278
Chronic obstructive pulmonary disease 18.14 9.71 341 244329 62345 63182007
Laryngeal injury 18.07 9.71 5 244665 8 63244344
Bundle branch block right 17.92 9.71 51 244619 4947 63239405
Cardiac valve disease 17.87 9.71 46 244624 4206 63240146
Purging 17.82 9.71 7 244663 47 63244305
Alcoholism 17.80 9.71 28 244642 1790 63242562
Creatinine renal clearance decreased 17.76 9.71 22 244648 16286 63228066
Feeling jittery 17.72 9.71 100 244570 13303 63231049
Formication 17.60 9.71 46 244624 4245 63240107
Mental disability 17.54 9.71 8 244662 81 63244271
Drug screen negative 17.38 9.71 12 244658 284 63244068
Diarrhoea 17.35 9.71 2455 242215 712911 62531441
Maternal exposure before pregnancy 17.34 9.71 4 244666 7599 63236753
Sarcomatoid carcinoma 17.25 9.71 6 244664 27 63244325
Pneumocystis jirovecii pneumonia 17.21 9.71 24 244646 16890 63227462
Blood bilirubin increased 17.19 9.71 79 244591 37061 63207291
Slow speech 17.02 9.71 25 244645 1504 63242848
Dermatitis allergic 16.96 9.71 20 244650 15128 63229224
Counterfeit product administered 16.91 9.71 6 244664 29 63244323
Autoimmune disorder 16.86 9.71 25 244645 17152 63227200
Body temperature decreased 16.79 9.71 33 244637 20286 63224066
Tenosynovitis 16.78 9.71 17 244653 13778 63230574
Foetal death 16.61 9.71 85 244585 10895 63233457
Graft versus host disease 16.58 9.71 3 244667 6760 63237592
Burn oesophageal 16.54 9.71 10 244660 187 63244165
Pneumonia streptococcal 16.51 9.71 27 244643 1784 63242568
Product quality issue 16.49 9.71 211 244459 35654 63208698
Electrocardiogram QRS complex shortened 16.47 9.71 14 244656 455 63243897
Tumour lysis syndrome 16.45 9.71 7 244663 8983 63235369
Diffuse large B-cell lymphoma 16.40 9.71 3 244667 6709 63237643
Deep vein thrombosis 16.37 9.71 431 244239 83369 63160983
Pulmonary toxicity 16.31 9.71 8 244662 9447 63234905
Gambling disorder 16.21 9.71 22 244648 1230 63243122
Nodular rash 16.17 9.71 10 244660 195 63244157
Product physical issue 16.12 9.71 49 244621 4931 63239421
Blood test abnormal 16.08 9.71 22 244648 15607 63228745
Abortion spontaneous 16.08 9.71 111 244559 47084 63197268
Gallbladder disorder 16.06 9.71 126 244544 18716 63225636
Poor venous access 16.04 9.71 20 244650 14765 63229587
Cardio-respiratory arrest neonatal 16.02 9.71 4 244666 3 63244349
Muscle rigidity 16.01 9.71 87 244583 11413 63232939
Contusion 15.95 9.71 448 244222 149596 63094756
Productive cough 15.94 9.71 161 244509 63047 63181305
Dyskinesia 15.89 9.71 191 244479 31811 63212541
Fear of injection 15.88 9.71 4 244666 7160 63237192
Tubulointerstitial nephritis 15.87 9.71 33 244637 19870 63224482
Anion gap increased 15.74 9.71 27 244643 1855 63242497
Oesophageal food impaction 15.65 9.71 10 244660 207 63244145
Toxic skin eruption 15.65 9.71 94 244576 12791 63231561
Bone density decreased 15.61 9.71 20 244650 14592 63229760
Therapy partial responder 15.58 9.71 11 244659 10647 63233705
Platelet count decreased 15.53 9.71 335 244335 115787 63128565
Areflexia 15.52 9.71 36 244634 3082 63241270
Victim of sexual abuse 15.49 9.71 16 244654 668 63243684
Obsessive-compulsive personality disorder 15.47 9.71 5 244665 17 63244335
Hepatic function abnormal 15.46 9.71 82 244588 37060 63207292
Alkalosis hypochloraemic 15.39 9.71 9 244661 158 63244194
Death of relative 15.24 9.71 11 244659 280 63244072
Encephalopathy 15.21 9.71 221 244449 38399 63205953
Metastases to bone 15.01 9.71 37 244633 20982 63223370
Faecal vomiting 14.91 9.71 15 244655 607 63243745
Constipation 14.87 9.71 1032 243638 223911 63020441
Coma scale 14.82 9.71 6 244664 44 63244308
Pre-existing condition improved 14.77 9.71 67 244603 8177 63236175
Pancreatitis acute 14.76 9.71 165 244505 27001 63217351
Joint effusion 14.72 9.71 27 244643 17033 63227319
Septic shock 14.69 9.71 175 244495 66454 63177898
Sedation complication 14.68 9.71 19 244651 13803 63230549
Therapeutic response unexpected 14.67 9.71 123 244547 18636 63225716
Blood creatinine increased 14.65 9.71 244 244426 87600 63156752
Lethargy 14.63 9.71 300 244370 55707 63188645
Respiratory rate decreased 14.61 9.71 38 244632 3497 63240855
Road traffic accident 14.58 9.71 210 244460 36422 63207930
Injection site erythema 14.55 9.71 229 244441 82945 63161407
Tubulointerstitial nephritis and uveitis syndrome 14.55 9.71 10 244660 235 63244117
Disorganised speech 14.54 9.71 21 244649 1244 63243108
Vascular headache 14.49 9.71 6 244664 47 63244305
Homicidal ideation 14.48 9.71 25 244645 1727 63242625
Normal newborn 14.48 9.71 7 244663 8334 63236018
Paraesthesia oral 14.39 9.71 125 244545 19131 63225221
Conversion disorder 14.36 9.71 25 244645 1739 63242613
Oesophageal achalasia 14.06 9.71 13 244657 473 63243879
Paranoia 14.06 9.71 85 244585 11594 63232758
Waxy flexibility 14.01 9.71 8 244662 134 63244218
Maximal voluntary ventilation abnormal 13.95 9.71 5 244665 25 63244327
Anion gap 13.90 9.71 21 244649 1296 63243056
Internal fixation of fracture 13.88 9.71 16 244654 757 63243595
Hallucination, olfactory 13.84 9.71 10 244660 255 63244097
Ear pain 13.81 9.71 82 244588 36036 63208316
Cerebral microangiopathy 13.77 9.71 10 244660 257 63244095
Neonatal behavioural syndrome 13.77 9.71 6 244664 54 63244298
LDL/HDL ratio increased 13.69 9.71 3 244667 0 63244352
Hyporesponsive to stimuli 13.69 9.71 19 244651 1085 63243267
Wrong rate 13.67 9.71 6 244664 55 63244297
Blood pressure systolic abnormal 13.61 9.71 19 244651 13367 63230985
Congenital central nervous system anomaly 13.60 9.71 11 244659 333 63244019
Laryngomalacia 13.49 9.71 6 244664 57 63244295
Hypokalaemia 13.44 9.71 508 244162 103296 63141056
Erythrodermic psoriasis 13.35 9.71 18 244652 1000 63243352
Hypotonia neonatal 13.34 9.71 20 244650 1226 63243126
Phobia 13.33 9.71 11 244659 343 63244009
Treatment noncompliance 13.31 9.71 210 244460 37115 63207237
Prothrombin level decreased 13.24 9.71 14 244656 601 63243751
Oedema 13.24 9.71 281 244389 97341 63147011
Diabetic ketoacidosis 13.20 9.71 38 244632 20467 63223885
Vaginal flatulence 13.20 9.71 35 244635 3258 63241094
Dysgeusia 13.14 9.71 253 244417 46457 63197895
Cardio-respiratory distress 13.03 9.71 8 244662 154 63244198
Syncope 13.01 9.71 565 244105 116820 63127532
Tardive dyskinesia 12.99 9.71 66 244604 8436 63235916
Eating disorder 12.97 9.71 121 244549 18895 63225457
Toxic epidermal necrolysis 12.88 9.71 52 244618 25282 63219070
Cutaneous lymphoma 12.85 9.71 8 244662 158 63244194
Staphylococcal infection 12.84 9.71 227 244443 41029 63203323
Cytomegalovirus viraemia 12.83 9.71 3 244667 5646 63238706
Anterograde amnesia 12.76 9.71 13 244657 534 63243818
Musculoskeletal disorder 12.76 9.71 39 244631 20605 63223747
Performance status decreased 12.68 9.71 37 244633 3641 63240711
Cognitive disorder 12.67 9.71 293 244377 55522 63188830
Suspiciousness 12.67 9.71 11 244659 368 63243984
Wrong patient 12.64 9.71 9 244661 224 63244128
Akathisia 12.60 9.71 69 244601 9077 63235275
Cellulitis 12.60 9.71 231 244439 81727 63162625
Multiple organ dysfunction syndrome 12.53 9.71 149 244521 56603 63187749
Peripheral circulatory failure 12.52 9.71 17 244653 951 63243401
Divorced 12.51 9.71 4 244666 13 63244339
Oropharyngeal pain 12.51 9.71 273 244397 94214 63150138
Burning sensation 12.47 9.71 286 244384 54121 63190231
Brugada syndrome 12.45 9.71 11 244659 377 63243975
Brain death 12.43 9.71 35 244635 3375 63240977
Myoclonus 12.38 9.71 104 244566 15764 63228588
Craniosynostosis 12.38 9.71 8 244662 169 63244183
Libido decreased 12.38 9.71 30 244640 2642 63241710
Rhinorrhoea 12.34 9.71 178 244492 65399 63178953
Atrioventricular septal defect 12.27 9.71 10 244660 306 63244046
Nasal polyps 12.23 9.71 4 244666 6035 63238317
Hyperaldosteronism 12.20 9.71 9 244661 237 63244115
Pneumonia aspiration 12.20 9.71 194 244476 34346 63210006
Soliloquy 12.17 9.71 9 244661 238 63244114
Gallbladder hypofunction 12.16 9.71 13 244657 565 63243787
Drug screen false positive 12.16 9.71 16 244654 868 63243484
Cushingoid 12.09 9.71 9 244661 8476 63235876
Laryngitis 12.02 9.71 30 244640 16937 63227415
Coagulation factor V level decreased 11.95 9.71 10 244660 318 63244034
Proctitis 11.91 9.71 47 244623 5394 63238958
Retrograde amnesia 11.88 9.71 12 244658 488 63243864
Postnatal growth restriction 11.87 9.71 4 244666 16 63244336
Crime 11.87 9.71 4 244666 16 63244336
Balance disorder 11.86 9.71 417 244253 84005 63160347
Tachycardia 11.85 9.71 563 244107 117593 63126759
Polyarthritis 11.79 9.71 13 244657 10133 63234219
Electroencephalogram abnormal 11.77 9.71 36 244634 3636 63240716
Coma scale abnormal 11.67 9.71 45 244625 5108 63239244
Burning mouth syndrome 11.66 9.71 12 244658 499 63243853
Injection site swelling 11.65 9.71 122 244548 47450 63196902
Carotid pulse abnormal 11.62 9.71 3 244667 3 63244349
Pelvic floor dysfunction 11.62 9.71 3 244667 3 63244349
Prothrombin level increased 11.55 9.71 9 244661 258 63244094
Skin ulcer 11.54 9.71 108 244562 42937 63201415
Blood creatine phosphokinase increased 11.54 9.71 173 244497 30257 63214095
Neurosis 11.52 9.71 9 244661 259 63244093
Premature labour 11.51 9.71 19 244651 12485 63231867
Deformity 11.47 9.71 17 244653 11667 63232685
Tendonitis 11.46 9.71 38 244632 19577 63224775
Ascites 11.44 9.71 101 244569 40627 63203725
Anxiety disorder 11.42 9.71 38 244632 4012 63240340
Localised infection 11.33 9.71 69 244601 30141 63214211
Perseveration 11.31 9.71 9 244661 266 63244086
Mean cell haemoglobin decreased 11.27 9.71 3 244667 5176 63239176
Reduced facial expression 11.25 9.71 24 244646 1942 63242410
Hepatotoxicity 11.24 9.71 90 244580 36951 63207401
Hepatic cirrhosis 11.22 9.71 53 244617 24681 63219671
Enthesopathy 11.20 9.71 10 244660 8604 63235748
Postmortem blood drug level abnormal 11.19 9.71 10 244660 348 63244004
Throat irritation 11.18 9.71 92 244578 37555 63206797
Cholecystectomy 11.18 9.71 75 244595 10602 63233750
Drug ineffective for unapproved indication 11.17 9.71 81 244589 33982 63210370
Corneal reflex decreased 11.17 9.71 7 244663 140 63244212
Electrocardiogram repolarisation abnormality 11.16 9.71 19 244651 1298 63243054
Ligament sprain 11.13 9.71 86 244584 12714 63231638
Economic problem 11.08 9.71 24 244646 1962 63242390
Haemangioma congenital 11.01 9.71 11 244659 441 63243911
Musculoskeletal pain 10.99 9.71 271 244399 92006 63152346
Asphyxia 10.90 9.71 50 244620 6131 63238221
Expired product administered 10.90 9.71 50 244620 6131 63238221
Clostridium difficile infection 10.88 9.71 69 244601 29853 63214499
Blood alcohol increased 10.88 9.71 13 244657 639 63243713
Osteonecrosis of jaw 10.81 9.71 85 244585 35038 63209314
Beta haemolytic streptococcal infection 10.77 9.71 24 244646 2001 63242351
Product counterfeit 10.70 9.71 7 244663 151 63244201
Purpura senile 10.69 9.71 12 244658 551 63243801
Attention deficit hyperactivity disorder 10.66 9.71 31 244639 3045 63241307
Depersonalisation/derealisation disorder 10.59 9.71 19 244651 1353 63242999
Mixed anxiety and depressive disorder 10.57 9.71 9 244661 293 63244059
Polydipsia 10.55 9.71 34 244636 3530 63240822
Therapeutic response decreased 10.55 9.71 170 244500 61355 63182997
Neuroglycopenia 10.50 9.71 11 244659 467 63243885
Sickle cell anaemia with crisis 10.48 9.71 5 244665 5998 63238354
Mood swings 10.45 9.71 112 244558 18136 63226216
Feeling of relaxation 10.44 9.71 5 244665 57 63244295
Cardioplegia 10.42 9.71 3 244667 6 63244346
Analgesic drug level decreased 10.42 9.71 3 244667 6 63244346
Hyperinsulinism 10.42 9.71 3 244667 6 63244346
Skin plaque 10.41 9.71 10 244660 8310 63236042
Hair texture abnormal 10.40 9.71 38 244632 4205 63240147
Muscle tightness 10.38 9.71 80 244590 11820 63232532
Exposure via inhalation 10.37 9.71 5 244665 58 63244294
Arthritis bacterial 10.37 9.71 6 244664 6457 63237895
Blood triglycerides increased 10.37 9.71 83 244587 12405 63231947
Pupil fixed 10.26 9.71 22 244648 1787 63242565
Blood oestrogen increased 10.22 9.71 6 244664 106 63244246
Blood lactate dehydrogenase increased 10.21 9.71 50 244620 23066 63221286
Venoocclusive liver disease 10.15 9.71 3 244667 4832 63239520
Vasculitis 10.15 9.71 36 244634 18173 63226179
Tobacco user 10.13 9.71 14 244656 796 63243556
Lip swelling 10.12 9.71 74 244596 30989 63213363
Cardiac hypertrophy 10.10 9.71 16 244654 1029 63243323
Nephropathy toxic 10.10 9.71 13 244657 9466 63234886
Multiple drug therapy 10.10 9.71 34 244636 3612 63240740
Oligohydramnios 10.08 9.71 6 244664 6360 63237992
Violence-related symptom 10.07 9.71 10 244660 398 63243954
Feeling drunk 10.07 9.71 37 244633 4105 63240247
Alcohol interaction 10.06 9.71 26 244644 2383 63241969
Dizziness 10.05 9.71 1842 242828 428083 62816269
Nail disorder 10.03 9.71 22 244648 12993 63231359
Vascular pseudoaneurysm ruptured 10.01 9.71 5 244665 63 63244289
Nephrosclerosis 10.00 9.71 16 244654 1038 63243314
Pleural effusion 9.98 9.71 278 244392 92932 63151420
Biliary dyskinesia 9.94 9.71 28 244642 2701 63241651
Joint dislocation 9.93 9.71 38 244632 18762 63225590
Sepsis syndrome 9.91 9.71 15 244655 927 63243425
Anion gap abnormal 9.91 9.71 10 244660 406 63243946
Alcohol withdrawal syndrome 9.91 9.71 14 244656 813 63243539
Regurgitation 9.90 9.71 21 244649 1693 63242659
Labelled drug-food interaction medication error 9.74 9.71 7 244663 177 63244175
Cross sensitivity reaction 9.72 9.71 24 244646 2138 63242214
Night sweats 9.72 9.71 131 244539 48683 63195669

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug abuse 7661.01 10.68 4464 109410 94632 34748425
Toxicity to various agents 2307.32 10.68 3035 110839 197327 34645730
Completed suicide 2187.99 10.68 2101 111773 96067 34746990
Respiratory arrest 1833.64 10.68 1140 112734 26903 34816154
Poisoning 1458.49 10.68 738 113136 11488 34831569
Cardio-respiratory arrest 1087.32 10.68 1107 112767 54166 34788891
Cardiac arrest 863.33 10.68 1297 112577 94862 34748195
Intentional product misuse 781.49 10.68 849 113025 44762 34798295
Drug dependence 771.69 10.68 636 113238 23581 34819476
Sopor 719.03 10.68 464 113410 11672 34831385
Coma 639.64 10.68 766 113108 44912 34798145
Suicide attempt 617.95 10.68 698 113176 38418 34804639
Overdose 575.13 10.68 1049 112825 90010 34753047
Intentional overdose 547.83 10.68 693 113181 42981 34800076
Poisoning deliberate 418.57 10.68 281 113593 7563 34835494
Exposure via ingestion 272.64 10.68 136 113738 2045 34841012
Withdrawal syndrome 261.90 10.68 259 113615 12196 34830861
Drug withdrawal syndrome 236.32 10.68 307 113567 19527 34823530
Prescription form tampering 234.76 10.68 79 113795 387 34842670
Off label use 226.99 10.68 662 113212 418862 34424195
Drug use disorder 216.08 10.68 147 113727 4044 34839013
Intentional self-injury 210.90 10.68 242 113632 13529 34829528
Somnolence 202.07 10.68 806 113068 110310 34732747
Substance abuse 199.14 10.68 179 113695 7462 34835595
Accidental overdose 192.12 10.68 280 113594 19860 34823197
Miosis 183.47 10.68 189 113685 9346 34833711
Suicidal ideation 157.02 10.68 382 113492 40006 34803051
Drug abuser 154.09 10.68 117 113757 3837 34839220
Bradypnoea 150.07 10.68 101 113773 2728 34840329
Anxiety 148.05 10.68 679 113195 98749 34744308
Respiratory depression 143.67 10.68 218 113656 16027 34827030
Death 137.68 10.68 1934 111940 396115 34446942
Agitation 135.15 10.68 453 113421 56946 34786111
Febrile neutropenia 133.89 10.68 149 113725 136700 34706357
Drug ineffective 123.19 10.68 928 112946 455823 34387234
Pyrexia 118.91 10.68 620 113254 332393 34510664
Depression 116.70 10.68 624 113250 96474 34746583
Depressed level of consciousness 112.49 10.68 351 113523 42490 34800567
Drug screen positive 105.97 10.68 94 113780 3849 34839208
Bradyphrenia 97.57 10.68 98 113776 4700 34838357
Insomnia 92.87 10.68 618 113256 103289 34739768
Asphyxia 89.62 10.68 111 113763 6724 34836333
Accidental death 87.68 10.68 69 113805 2387 34840670
Pneumonia 84.67 10.68 765 113109 361862 34481195
Sepsis 78.32 10.68 279 113595 166282 34676775
Panic attack 75.62 10.68 121 113753 9311 34833746
Treatment failure 75.12 10.68 29 113845 46668 34796389
COVID-19 73.00 10.68 87 113787 77463 34765594
Aggression 72.57 10.68 285 113589 38679 34804378
Counterfeit product administered 70.09 10.68 25 113849 150 34842907
Neutropenia 69.52 10.68 269 113605 156509 34686548
Unresponsive to stimuli 66.99 10.68 220 113654 27349 34815708
Renal impairment 66.81 10.68 129 113745 94384 34748673
Infection 65.21 10.68 123 113751 90792 34752265
Product use in unapproved indication 64.16 10.68 184 113690 117315 34725742
Alcohol interaction 62.00 10.68 61 113813 2852 34840205
C-reactive protein increased 60.83 10.68 52 113822 54046 34789011
Product counterfeit 60.60 10.68 22 113852 140 34842917
Amnesia 60.14 10.68 207 113667 26356 34816701
Cough 60.09 10.68 268 113606 149872 34693185
Infusion related reaction 58.44 10.68 52 113822 53005 34790052
Irritability 57.30 10.68 194 113680 24496 34818561
Lower respiratory tract infection 57.29 10.68 16 113858 31621 34811436
Cytomegalovirus infection 55.94 10.68 9 113865 26126 34816931
Drug detoxification 55.81 10.68 24 113850 251 34842806
Drug resistance 55.33 10.68 9 113865 25918 34817139
Pulmonary oedema 54.69 10.68 302 113572 47227 34795830
Platelet count decreased 54.60 10.68 203 113671 119514 34723543
Abnormal behaviour 54.30 10.68 192 113682 24777 34818280
Loss of consciousness 54.15 10.68 457 113417 82210 34760847
Toxicologic test abnormal 53.24 10.68 29 113845 527 34842530
Anaemia 53.11 10.68 495 113379 232840 34610217
Self-medication 50.95 10.68 53 113821 2650 34840407
Postmortem blood drug level abnormal 50.55 10.68 23 113851 278 34842779
Rash 50.06 10.68 474 113400 222278 34620779
Condition aggravated 48.92 10.68 396 113478 191800 34651257
Myelosuppression 47.76 10.68 4 113870 19261 34823796
Diarrhoea 47.69 10.68 940 112934 388972 34454085
Disease progression 46.87 10.68 187 113687 107890 34735167
Drug tolerance 46.41 10.68 52 113822 2830 34840227
Mucosal inflammation 44.80 10.68 36 113838 38586 34804471
Tremor 43.66 10.68 436 113438 82151 34760906
Hepatic function abnormal 43.65 10.68 48 113826 44315 34798742
Disorientation 41.66 10.68 216 113658 32972 34810085
Narcotic bowel syndrome 41.05 10.68 16 113858 127 34842930
Alcohol abuse 40.13 10.68 62 113812 4628 34838429
General physical health deterioration 40.07 10.68 249 113625 128020 34715037
Disturbance in attention 39.88 10.68 179 113695 25766 34817291
Arthralgia 39.83 10.68 358 113516 169683 34673374
Psychomotor hyperactivity 39.51 10.68 93 113781 9529 34833528
Substance use disorder 39.39 10.68 27 113847 752 34842305
Dyspnoea 39.19 10.68 932 112942 375850 34467207
Cardiac failure 38.85 10.68 159 113715 91089 34751968
Joint swelling 38.70 10.68 86 113788 59804 34783253
Acute kidney injury 38.52 10.68 731 113143 304257 34538800
Altered state of consciousness 38.29 10.68 162 113712 22731 34820326
Pulmonary congestion 38.17 10.68 115 113759 13650 34829407
Thinking abnormal 37.73 10.68 70 113804 6067 34836990
Accidental poisoning 36.71 10.68 26 113848 764 34842293
Anger 36.52 10.68 103 113771 11781 34831276
Drug intolerance 36.51 10.68 88 113786 59482 34783575
Therapeutic product effect incomplete 35.67 10.68 69 113805 50472 34792585
Abulia 35.66 10.68 23 113851 577 34842480
Road traffic accident 35.24 10.68 131 113743 17319 34825738
Brain oedema 35.11 10.68 112 113762 13709 34829348
Neutrophil count decreased 35.01 10.68 71 113803 51033 34792024
White blood cell count decreased 34.85 10.68 176 113698 95269 34747788
Suspected suicide 34.14 10.68 58 113816 4690 34838367
Drug withdrawal syndrome neonatal 34.04 10.68 50 113824 3569 34839488
Confusional state 33.37 10.68 657 113217 143503 34699554
Pancytopenia 33.32 10.68 178 113696 94979 34748078
Alcohol use 33.23 10.68 47 113827 3241 34839816
Nervousness 32.80 10.68 103 113771 12503 34830554
Substance abuser 32.74 10.68 13 113861 109 34842948
Manic symptom 32.74 10.68 13 113861 109 34842948
Blood pressure fluctuation 32.60 10.68 21 113853 25228 34817829
Dependence 32.07 10.68 28 113846 1122 34841935
Haemoglobin decreased 32.01 10.68 246 113628 120526 34722531
Rheumatoid arthritis 31.78 10.68 47 113827 38191 34804866
Prostate cancer 31.74 10.68 50 113824 39599 34803458
Neutropenic sepsis 31.19 10.68 4 113870 13763 34829294
Dysarthria 31.09 10.68 207 113667 34575 34808482
Angioedema 31.00 10.68 46 113828 37328 34805729
Blood creatinine increased 30.89 10.68 182 113692 94794 34748263
Mydriasis 30.86 10.68 71 113803 7166 34835891
Inappropriate schedule of product administration 30.81 10.68 102 113772 62194 34780863
Withdrawal catatonia 30.71 10.68 12 113862 96 34842961
Pneumocystis jirovecii pneumonia 30.46 10.68 13 113861 19697 34823360
Respiratory rate decreased 30.43 10.68 38 113836 2321 34840736
Anorgasmia 30.43 10.68 24 113850 833 34842224
Homicide 30.35 10.68 25 113849 924 34842133
Malignant neoplasm progression 30.10 10.68 166 113708 87880 34755177
Bradykinesia 29.92 10.68 49 113825 3844 34839213
Respiratory failure 29.79 10.68 219 113655 108353 34734704
Ascites 29.17 10.68 68 113806 46503 34796554
Paramnesia 28.78 10.68 8 113866 17 34843040
Interstitial lung disease 28.25 10.68 113 113761 65169 34777888
Cytokine release syndrome 28.23 10.68 20 113854 22857 34820200
Hyperthermia 28.05 10.68 87 113787 10490 34832567
Gastrointestinal haemorrhage 28.01 10.68 171 113703 88306 34754751
Bladder dilatation 27.66 10.68 29 113845 1463 34841594
Feeling abnormal 27.45 10.68 321 113553 62914 34780143
Bone marrow failure 27.32 10.68 33 113841 29220 34813837
Heart rate decreased 26.40 10.68 39 113835 31706 34811351
Analgesic drug level increased 26.23 10.68 22 113852 834 34842223
Panic disorder 26.21 10.68 26 113848 1228 34841829
Exposure during pregnancy 26.07 10.68 76 113798 8858 34834199
Haematochezia 26.01 10.68 72 113802 46462 34796595
Pneumonia aspiration 25.51 10.68 228 113646 41675 34801382
Generalised anxiety disorder 25.15 10.68 21 113853 791 34842266
Stomatitis 25.11 10.68 64 113810 42450 34800607
Erythema 24.87 10.68 178 113696 88602 34754455
Gun shot wound 24.72 10.68 24 113850 1104 34841953
Alanine aminotransferase increased 24.64 10.68 158 113716 80657 34762400
Hypervolaemia 24.62 10.68 17 113857 19692 34823365
Serotonin syndrome 24.50 10.68 129 113745 19804 34823253
Sedation 24.50 10.68 134 113740 20872 34822185
Cerebral haemorrhage 24.39 10.68 48 113826 34889 34808168
Distributive shock 24.38 10.68 25 113849 1229 34841828
Obstructive airways disorder 24.29 10.68 10 113864 15484 34827573
Pruritus 24.00 10.68 322 113552 141659 34701398
Hypervigilance 23.81 10.68 11 113863 138 34842919
Bronchopulmonary aspergillosis 23.74 10.68 9 113865 14650 34828407
Hospitalisation 23.68 10.68 100 113774 56802 34786255
Nasopharyngitis 23.32 10.68 133 113741 69835 34773222
Renal failure 23.20 10.68 293 113581 130264 34712793
Hallucination, visual 23.16 10.68 117 113757 17674 34825383
Dissociative disorder 23.11 10.68 16 113858 453 34842604
Drug tolerance increased 22.90 10.68 16 113858 460 34842597
Aspergillus infection 22.55 10.68 6 113868 12248 34830809
Hyperleukocytosis 22.31 10.68 30 113844 1972 34841085
Inadequate analgesia 22.26 10.68 37 113837 2938 34840119
Catatonia 22.21 10.68 50 113824 4975 34838082
Drug withdrawal convulsions 22.04 10.68 23 113851 1154 34841903
Anaphylactic reaction 22.02 10.68 45 113829 32256 34810801
Atrial fibrillation 22.00 10.68 274 113600 122119 34720938
Deafness neurosensory 21.88 10.68 36 113838 2835 34840222
Poverty of speech 21.74 10.68 12 113862 224 34842833
Drug diversion 21.74 10.68 20 113854 859 34842198
Contraindicated product administered 21.39 10.68 23 113851 21458 34821599
Ventricular fibrillation 21.32 10.68 26 113848 22928 34820129
Vestibular ischaemia 21.20 10.68 6 113868 14 34843043
Psoriatic arthropathy 21.09 10.68 20 113854 19778 34823279
Chorea 20.90 10.68 22 113852 1115 34841942
Pathogen resistance 20.90 10.68 3 113871 9479 34833578
Major depression 20.77 10.68 46 113828 4526 34838531
Cardiac failure congestive 20.49 10.68 173 113701 83097 34759960
Bladder cancer 20.39 10.68 14 113860 16264 34826793
Wheezing 20.32 10.68 68 113806 41334 34801723
Blood pressure systolic increased 20.28 10.68 27 113847 22925 34820132
Puncture site haematoma 20.24 10.68 10 113864 147 34842910
Speech disorder 20.10 10.68 148 113726 25538 34817519
Dizziness 20.09 10.68 550 113324 217971 34625086
Oedematous pancreatitis 20.01 10.68 15 113859 482 34842575
Sudden death 19.81 10.68 100 113774 15101 34827956
Bacteraemia 19.76 10.68 21 113853 19696 34823361
Faecal disimpaction 19.65 10.68 6 113868 20 34843037
Hyporesponsive to stimuli 19.59 10.68 21 113853 1087 34841970
Myotonia 19.49 10.68 7 113867 43 34843014
Pleural effusion 19.36 10.68 171 113703 81375 34761682
Hypersensitivity 19.29 10.68 118 113756 60917 34782140
Acute myocardial infarction 19.06 10.68 100 113774 53619 34789438
Asthma 18.98 10.68 73 113801 42583 34800474
Papillary muscle disorder 18.92 10.68 4 113870 0 34843057
Legal problem 18.85 10.68 10 113864 172 34842885
Arthropathy 18.75 10.68 37 113837 26870 34816187
Hypothermia 18.70 10.68 77 113797 10671 34832386
Haemorrhage 18.58 10.68 95 113779 51275 34791782
Delirium 18.50 10.68 222 113652 43769 34799288
Urticaria 18.48 10.68 123 113751 62254 34780803
Cerebral congestion 18.42 10.68 6 113868 26 34843031
Hallucination 18.33 10.68 252 113622 51246 34791811
Tubulointerstitial nephritis 18.30 10.68 25 113849 20999 34822058
Hepatotoxicity 18.25 10.68 26 113848 21459 34821598
Appendicitis 18.20 10.68 13 113861 14794 34828263
Slow speech 18.19 10.68 21 113853 1181 34841876
Leukopenia 18.10 10.68 125 113749 62731 34780326
Oedema peripheral 18.03 10.68 278 113596 119534 34723523
Memory impairment 17.96 10.68 218 113656 43100 34799957
Blood triglycerides abnormal 17.94 10.68 11 113863 252 34842805
Herpes zoster 17.93 10.68 55 113819 34344 34808713
Feeling jittery 17.88 10.68 40 113834 3963 34839094
Electrocardiogram QT prolonged 17.81 10.68 208 113666 40744 34802313
Stevens-Johnson syndrome 17.43 10.68 21 113853 18618 34824439
Lip swelling 17.41 10.68 16 113858 16064 34826993
Mania 17.24 10.68 69 113805 9442 34833615
Inflammation 17.17 10.68 42 113832 28253 34814804
Nephropathy toxic 16.90 10.68 10 113864 12578 34830479
Sexual dysfunction 16.86 10.68 52 113822 6251 34836806
Bacterial prostatitis 16.82 10.68 7 113867 67 34842990
Growth hormone deficiency 16.81 10.68 11 113863 283 34842774
Hyperkalaemia 16.69 10.68 145 113729 69244 34773813
Lymphadenopathy 16.69 10.68 43 113831 28420 34814637
Anamnestic reaction 16.68 10.68 6 113868 37 34843020
Leukoencephalopathy 16.50 10.68 40 113834 4175 34838882
Cerebral infarction 16.47 10.68 41 113833 27414 34815643
Victim of crime 16.41 10.68 12 113862 371 34842686
Oesophageal carcinoma 16.30 10.68 5 113869 9299 34833758
Brachial plexus injury 16.21 10.68 7 113867 74 34842983
Product substitution 16.04 10.68 6 113868 42 34843015
Liver function test abnormal 15.97 10.68 50 113824 31024 34812033
Myocardial infarction 15.91 10.68 288 113586 120797 34722260
Multiple organ dysfunction syndrome 15.86 10.68 166 113708 76400 34766657
Peripheral swelling 15.84 10.68 166 113708 76375 34766682
Hypogammaglobulinaemia 15.83 10.68 3 113871 7737 34835320
Accident 15.76 10.68 44 113830 5003 34838054
Hypokinesia 15.76 10.68 64 113810 8816 34834241
Homicidal ideation 15.75 10.68 30 113844 2652 34840405
Acute myeloid leukaemia 15.63 10.68 22 113852 18248 34824809
Incorrect route of product administration 15.54 10.68 92 113782 14753 34828304
Gastric haemorrhage 15.49 10.68 7 113867 10254 34832803
Full blood count abnormal 15.46 10.68 23 113851 18645 34824412
Negativism 15.45 10.68 12 113862 407 34842650
Therapy partial responder 15.41 10.68 6 113868 9610 34833447
Cyclothymic disorder 15.28 10.68 7 113867 86 34842971
Foetal exposure during pregnancy 15.21 10.68 68 113806 38033 34805024
Liver function test increased 15.18 10.68 15 113859 14550 34828507
Cardio-respiratory distress 15.16 10.68 8 113866 136 34842921
Diabetic ketoacidosis 15.14 10.68 22 113852 18010 34825047
Tachyphylaxis 15.01 10.68 8 113866 139 34842918
COVID-19 pneumonia 14.95 10.68 20 113854 16947 34826110
Prothrombin time shortened 14.90 10.68 21 113853 1443 34841614
Thymus disorder 14.90 10.68 4 113870 7 34843050
Melaena 14.83 10.68 62 113812 35318 34807739
Epistaxis 14.79 10.68 120 113754 58131 34784926
Hypocalcaemia 14.78 10.68 36 113838 24253 34818804
Thrombocytopenia 14.67 10.68 392 113482 155855 34687202
Sluggishness 14.65 10.68 33 113841 3284 34839773
Amimia 14.55 10.68 4 113870 8 34843049
Lactic acidosis 14.53 10.68 61 113813 34711 34808346
Chronic fatigue syndrome 14.50 10.68 11 113863 360 34842697
Therapeutic response decreased 14.48 10.68 48 113826 29265 34813792
Osteoporosis 14.45 10.68 12 113862 12656 34830401
Mobility decreased 14.43 10.68 50 113824 30078 34812979
Ventricular tachyarrhythmia 14.42 10.68 11 113863 363 34842694
Liver disorder 14.34 10.68 57 113817 32940 34810117
Low birth weight baby 14.30 10.68 4 113870 7901 34835156
Oesophagitis chemical 14.28 10.68 6 113868 59 34842998
Cataract 14.27 10.68 41 113833 26145 34816912
Second primary malignancy 14.25 10.68 4 113870 7882 34835175
Sepsis pasteurella 14.19 10.68 3 113871 0 34843057
Neurotoxicity 14.14 10.68 23 113851 17987 34825070
Transplant rejection 14.11 10.68 8 113866 10303 34832754
Squamous cell carcinoma of skin 14.11 10.68 9 113865 10872 34832185
Body temperature decreased 14.08 10.68 13 113861 13021 34830036
Physical assault 14.06 10.68 18 113856 1127 34841930
Hepatic cytolysis 14.01 10.68 88 113786 14408 34828649
Blood triglycerides decreased 13.99 10.68 7 113867 106 34842951
Incision site pain 13.94 10.68 23 113851 1815 34841242
Cellulitis 13.94 10.68 108 113766 52843 34790214
Upper gastrointestinal haemorrhage 13.88 10.68 40 113834 25478 34817579
Therapy non-responder 13.81 10.68 73 113801 39073 34803984
Pneumonitis 13.81 10.68 60 113814 33818 34809239
Intrusive thoughts 13.79 10.68 10 113864 305 34842752
Femoral artery aneurysm 13.79 10.68 8 113866 165 34842892
Prescription drug used without a prescription 13.78 10.68 25 113849 2129 34840928
Blood creatine phosphokinase 13.76 10.68 7 113867 110 34842947
Oedema 13.64 10.68 90 113784 45651 34797406
Product use issue 13.53 10.68 136 113738 63080 34779977
Bipolar disorder 13.50 10.68 34 113840 3635 34839422
Drug screen negative 13.49 10.68 8 113866 172 34842885
Judgement impaired 13.37 10.68 13 113861 599 34842458
Malaise 13.36 10.68 483 113391 185342 34657715
Panic reaction 13.33 10.68 20 113854 1455 34841602
Abdominal distension 13.29 10.68 124 113750 58368 34784689
Blood lactate dehydrogenase increased 13.27 10.68 35 113839 22955 34820102
Central nervous system necrosis 13.27 10.68 7 113867 119 34842938
Tumour lysis syndrome 13.19 10.68 22 113852 17037 34826020
Oropharyngeal pain 13.19 10.68 65 113809 35420 34807637
Hepatic enzyme increased 13.17 10.68 74 113800 39006 34804051
Haemoconcentration 13.13 10.68 5 113869 37 34843020
Pulmonary fibrosis 13.08 10.68 25 113849 18371 34824686
Victim of homicide 13.06 10.68 7 113867 123 34842934
Theft 13.06 10.68 9 113865 253 34842804
Chemical poisoning 13.01 10.68 7 113867 124 34842933
Cholangitis 13.00 10.68 6 113868 8683 34834374
Osteonecrosis of jaw 12.99 10.68 24 113850 17865 34825192
Alcohol poisoning 12.91 10.68 33 113841 3560 34839497
Peripheral nerve paresis 12.90 10.68 5 113869 39 34843018
Exposure via inhalation 12.90 10.68 5 113869 39 34843018
Basal cell carcinoma 12.88 10.68 28 113846 19630 34823427
Septic shock 12.82 10.68 161 113713 71673 34771384
Self esteem decreased 12.82 10.68 12 113862 527 34842530
Myoclonus 12.77 10.68 87 113787 14638 34828419
Progressive multifocal leukoencephalopathy 12.77 10.68 8 113866 9756 34833301
Aplastic anaemia 12.65 10.68 8 113866 9708 34833349
Anticholinergic syndrome 12.62 10.68 18 113856 1251 34841806
Impatience 12.61 10.68 10 113864 350 34842707
Conversion disorder 12.56 10.68 10 113864 352 34842705
Hyperhidrosis 12.49 10.68 329 113545 75363 34767694
Personality change 12.47 10.68 41 113833 5098 34837959
Pulseless electrical activity 12.41 10.68 4 113870 7207 34835850
Product dose omission issue 12.40 10.68 296 113578 119415 34723642
Bezoar 12.38 10.68 17 113857 1140 34841917
Intentional product use issue 12.26 10.68 130 113744 59686 34783371
Thrombotic microangiopathy 12.21 10.68 10 113864 10620 34832437
Hallucinations, mixed 12.16 10.68 27 113847 2662 34840395
Shoplifting 12.12 10.68 3 113871 3 34843054
Aspartate aminotransferase increased 12.07 10.68 152 113722 67631 34775426
Acute hepatic failure 11.99 10.68 17 113857 14057 34829000
Substance-induced mood disorder 11.98 10.68 6 113868 91 34842966
Euphoric mood 11.94 10.68 43 113831 5598 34837459
Colitis 11.91 10.68 73 113801 37677 34805380
Blood alcohol increased 11.82 10.68 14 113860 809 34842248
Oropharyngeal oedema 11.81 10.68 6 113868 94 34842963
Nystagmus 11.78 10.68 38 113836 4677 34838380
Clonus 11.75 10.68 27 113847 2723 34840334
Mood altered 11.74 10.68 59 113815 8893 34834164
Extrapyramidal disorder 11.71 10.68 77 113797 12803 34830254
Polyneuropathy 11.71 10.68 19 113855 14877 34828180
Adrenergic syndrome 11.69 10.68 6 113868 96 34842961
Neoplasm progression 11.62 10.68 38 113836 23262 34819795
Cardiorenal syndrome 11.56 10.68 13 113861 710 34842347
Apathy 11.55 10.68 49 113825 6883 34836174
Bronchiectasis 11.53 10.68 9 113865 9792 34833265
Clostridium difficile colitis 11.51 10.68 21 113853 15709 34827348
Chloasma 11.51 10.68 4 113870 22 34843035
Haemolysis 11.49 10.68 6 113868 8088 34834969
Productive cough 11.48 10.68 74 113800 37739 34805318
Disease recurrence 11.46 10.68 34 113840 21456 34821601
Bacterial infection 11.43 10.68 24 113850 17039 34826018
Erythema multiforme 11.43 10.68 7 113867 8642 34834415
Influenza 11.41 10.68 105 113769 49561 34793496
Erectile dysfunction 11.40 10.68 110 113764 20527 34822530
Urosepsis 11.36 10.68 15 113859 12784 34830273
Pulmonary toxicity 11.33 10.68 3 113871 6144 34836913
Injury 11.30 10.68 110 113764 20577 34822480
Victim of chemical submission 11.25 10.68 5 113869 57 34843000
Visceral congestion 11.24 10.68 12 113862 618 34842439
Atrial flutter 11.21 10.68 21 113853 15553 34827504
Colitis microscopic 11.17 10.68 24 113850 2313 34840744
Abdominal pain 11.15 10.68 428 113446 163190 34679867
Obsessive thoughts 11.11 10.68 13 113861 742 34842315
Pericardial effusion 11.10 10.68 42 113832 24620 34818437
Loss of personal independence in daily activities 11.09 10.68 63 113811 33116 34809941
Amnestic disorder 11.06 10.68 8 113866 243 34842814
Proteinuria 11.06 10.68 28 113846 18614 34824443
Acute stress disorder 11.05 10.68 7 113867 170 34842887
Hypercalcaemia 11.01 10.68 21 113853 15447 34827610
Fear 11.01 10.68 65 113809 10411 34832646
Drug eruption 10.96 10.68 31 113843 19867 34823190
Drug ineffective for unapproved indication 10.93 10.68 40 113834 23675 34819382
Nervous system disorder 10.92 10.68 83 113791 14460 34828597
Benign mesenteric neoplasm 10.91 10.68 3 113871 6 34843051
Paranoia 10.89 10.68 72 113802 11996 34831061
Osteonecrosis 10.79 10.68 20 113854 14870 34828187
Sputum discoloured 10.78 10.68 6 113868 7806 34835251
Hypophosphataemia 10.76 10.68 12 113862 11014 34832043
Urinary tract infection 10.72 10.68 201 113673 83880 34759177

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug abuse 12826.30 9.57 7743 283203 154948 79298494
Completed suicide 6685.09 9.57 6175 284771 239592 79213850
Toxicity to various agents 4258.26 9.57 6368 284578 415172 79038270
Respiratory arrest 3471.11 9.57 2320 288626 55230 79398212
Sopor 2895.94 9.57 1689 289257 31321 79422121
Poisoning 2544.41 9.57 1415 289531 23857 79429585
Cardio-respiratory arrest 2159.63 9.57 2306 288640 106204 79347238
Cardiac arrest 1888.32 9.57 2710 288236 169386 79284056
Suicide attempt 1666.36 9.57 1772 289174 81160 79372282
Intentional overdose 1604.44 9.57 1955 288991 104005 79349437
Coma 1505.95 9.57 1846 289100 98803 79354639
Poisoning deliberate 1315.35 9.57 833 290113 17995 79435447
Intentional product misuse 1273.40 9.57 1651 289295 93514 79359928
Overdose 1264.90 9.57 2347 288599 181859 79271583
Drug dependence 1209.33 9.57 1079 289867 39690 79413752
Intentional self-injury 701.17 9.57 721 290225 31698 79421744
Somnolence 696.28 9.57 2184 288762 236797 79216645
Death 523.02 9.57 3695 287251 562819 78890623
Off label use 457.93 9.57 1736 289210 905479 78547963
Exposure via ingestion 446.14 9.57 262 290684 4912 79448530
Drug ineffective 435.44 9.57 2251 288695 1078662 78374780
Drug withdrawal syndrome 427.95 9.57 579 290367 34139 79419303
Drug use disorder 404.98 9.57 299 290647 8352 79445090
Substance abuse 401.24 9.57 322 290624 10204 79443238
Synovitis 387.78 9.57 47 290899 150687 79302755
Bradyphrenia 368.86 9.57 308 290638 10332 79443110
Withdrawal syndrome 357.36 9.57 465 290481 26389 79427053
Pemphigus 337.12 9.57 5 290941 99577 79353865
Hand deformity 325.94 9.57 12 290934 103907 79349535
Drug abuser 309.19 9.57 220 290726 5793 79447649
Lower respiratory tract infection 305.12 9.57 52 290894 129168 79324274
Suicidal ideation 300.13 9.57 778 290168 75562 79377880
Drug intolerance 294.91 9.57 317 290629 263802 79189640
Accidental overdose 290.86 9.57 520 290426 39061 79414381
Contraindicated product administered 286.59 9.57 108 290838 157430 79296012
Joint swelling 283.50 9.57 383 290563 288263 79165179
Anti-cyclic citrullinated peptide antibody positive 282.19 9.57 4 290942 83139 79370303
Pericarditis 269.30 9.57 32 290914 104204 79349238
Treatment failure 269.18 9.57 143 290803 170343 79283099
Anxiety 266.34 9.57 1684 289262 246828 79206614
Agitation 259.80 9.57 878 290068 98837 79354605
Systemic lupus erythematosus 254.58 9.57 64 290882 121085 79332357
Mydriasis 248.09 9.57 314 290632 17329 79436113
Miosis 244.54 9.57 295 290651 15494 79437948
Arthropathy 236.50 9.57 180 290766 176931 79276511
Depression 233.45 9.57 1471 289475 215319 79238123
Duodenal ulcer perforation 221.26 9.57 4 290942 66207 79387235
Infusion related reaction 215.54 9.57 316 290630 229921 79223521
Nasopharyngitis 204.66 9.57 384 290562 253497 79199945
Maternal exposure during pregnancy 203.36 9.57 123 290823 136415 79317027
Infection 200.71 9.57 359 290587 241353 79212089
Depressed level of consciousness 197.76 9.57 787 290159 95865 79357577
Febrile neutropenia 196.41 9.57 338 290608 230661 79222781
Glossodynia 196.18 9.57 66 290880 103271 79350171
Rheumatoid arthritis 193.29 9.57 288 290658 208182 79245260
Bradypnoea 193.01 9.57 167 290779 5885 79447557
Helicobacter infection 191.42 9.57 17 290929 69687 79383755
Respiratory depression 189.06 9.57 352 290594 27278 79426164
Loss of consciousness 183.48 9.57 1144 289802 166799 79286643
Arthralgia 176.71 9.57 1291 289655 570512 78882930
Pyrexia 168.42 9.57 1624 289322 677085 78776357
Prescription form tampering 165.63 9.57 60 290886 332 79453110
General physical health deterioration 163.06 9.57 490 290456 274748 79178694
Swelling 161.56 9.57 343 290603 216368 79237074
Folliculitis 159.10 9.57 11 290935 55369 79398073
Panic attack 156.39 9.57 301 290645 23915 79429527
Therapeutic product effect decreased 155.18 9.57 223 290723 163640 79289802
Drug screen positive 151.66 9.57 146 290800 5917 79447525
Altered state of consciousness 148.55 9.57 423 290523 43399 79410043
Alopecia 147.97 9.57 397 290549 230958 79222484
Discomfort 145.46 9.57 146 290800 125471 79327971
Rash 143.31 9.57 1384 289562 576974 78876468
Victim of chemical submission 142.08 9.57 59 290887 495 79452947
Wound 141.56 9.57 129 290817 116050 79337392
Hypersensitivity 139.26 9.57 490 290456 261749 79191693
Bradykinesia 139.05 9.57 159 290787 7884 79445558
Tremor 136.59 9.57 1075 289871 169008 79284434
Hepatic enzyme increased 135.28 9.57 290 290656 182320 79271122
Pneumonia 134.40 9.57 1653 289293 658593 78794849
Sleep disorder due to general medical condition, insomnia type 130.10 9.57 7 290939 43549 79409893
C-reactive protein increased 127.76 9.57 170 290776 128857 79324585
Rheumatoid factor positive 123.03 9.57 33 290913 59806 79393636
Disturbance in attention 121.56 9.57 435 290511 50366 79403076
Alcohol abuse 120.87 9.57 122 290824 5241 79448201
Insomnia 119.40 9.57 1394 289552 243776 79209666
Abdominal discomfort 118.57 9.57 491 290455 250236 79203206
Peripheral swelling 118.38 9.57 543 290403 269074 79184368
Cough 118.04 9.57 818 290128 365971 79087471
Product use in unapproved indication 115.47 9.57 495 290451 249864 79203578
Myelosuppression 112.91 9.57 9 290937 40287 79413155
Muscle injury 111.43 9.57 21 290925 48540 79404902
Stomatitis 107.07 9.57 235 290711 146522 79306920
Accidental death 106.71 9.57 103 290843 4188 79449254
COVID-19 106.59 9.57 263 290683 157411 79296031
Sepsis 105.97 9.57 564 290382 268864 79184578
Drug resistance 104.11 9.57 15 290931 42198 79411244
Blister 100.40 9.57 176 290770 119300 79334142
Aggression 100.25 9.57 410 290536 50548 79402894
Condition aggravated 98.69 9.57 1263 289683 499861 78953581
Renal impairment 96.93 9.57 276 290670 157507 79295935
Suspected suicide 95.00 9.57 152 290794 10424 79443018
Neutropenia 94.32 9.57 638 290308 287072 79166370
Product use issue 93.00 9.57 421 290525 209401 79244041
Disorientation 92.01 9.57 463 290483 62313 79391129
Cytomegalovirus infection 90.58 9.57 22 290924 42622 79410820
Hepatocellular injury 89.76 9.57 378 290568 47215 79406227
Sinusitis 89.22 9.57 388 290558 195113 79258329
Wheezing 88.27 9.57 183 290763 116481 79336961
Impaired healing 87.26 9.57 115 290831 87540 79365902
Rheumatic fever 87.06 9.57 4 290942 28521 79424921
Gastrointestinal disorder 85.63 9.57 200 290746 122005 79331437
Abnormal behaviour 85.54 9.57 310 290636 36111 79417331
Dyspnoea 85.26 9.57 2429 288517 854596 78598846
Mucosal inflammation 85.04 9.57 90 290856 75490 79377952
Psoriatic arthropathy 83.24 9.57 97 290849 77902 79375540
Confusional state 82.05 9.57 1622 289324 316375 79137067
Hypokinesia 80.85 9.57 200 290746 18860 79434582
Irritable bowel syndrome 80.82 9.57 65 290881 62176 79391266
Musculoskeletal stiffness 80.67 9.57 346 290600 174662 79278780
Substance use disorder 79.56 9.57 47 290899 891 79452551
Neutropenic sepsis 78.84 9.57 5 290941 27059 79426383
Intentional product use issue 78.18 9.57 288 290658 151824 79301618
Psychomotor hyperactivity 74.88 9.57 180 290766 16669 79436773
Drug detoxification 74.26 9.57 34 290912 369 79453073
Platelet count decreased 73.48 9.57 413 290533 194251 79259191
Blood pressure fluctuation 72.19 9.57 83 290863 67062 79386380
Dependence 71.56 9.57 64 290882 2358 79451084
Neutrophil count decreased 71.40 9.57 147 290799 93812 79359630
Toxicologic test abnormal 70.48 9.57 50 290896 1310 79452132
Irritability 69.38 9.57 316 290630 40828 79412614
Asphyxia 68.82 9.57 140 290806 11580 79441862
Mobility decreased 68.39 9.57 223 290723 121952 79331490
Malignant neoplasm progression 67.59 9.57 261 290685 135729 79317713
Homicide 67.06 9.57 46 290900 1140 79452302
Nervousness 66.63 9.57 270 290676 33145 79420297
Unresponsive to stimuli 66.56 9.57 389 290557 55399 79398043
Electrocardiogram QT prolonged 66.40 9.57 560 290386 89826 79363616
Serotonin syndrome 64.51 9.57 330 290616 44697 79408745
Alcohol interaction 64.21 9.57 84 290862 4790 79448652
Drug interaction 64.11 9.57 1975 288971 413208 79040234
Therapeutic product effect incomplete 64.07 9.57 282 290664 141363 79312079
Knee arthroplasty 62.92 9.57 40 290906 43208 79410234
Diarrhoea 62.72 9.57 2602 288344 877887 78575555
Fall 62.65 9.57 2270 288676 485359 78968083
Euphoric mood 62.60 9.57 106 290840 7620 79445822
Amnesia 61.72 9.57 418 290528 62639 79390803
Disease progression 60.29 9.57 409 290537 183953 79269489
Crying 60.05 9.57 203 290743 22840 79430602
Psychomotor skills impaired 59.50 9.57 84 290862 5153 79448289
Product counterfeit 59.18 9.57 26 290920 254 79453188
Counterfeit product administered 58.30 9.57 21 290925 114 79453328
Ill-defined disorder 58.14 9.57 94 290852 65781 79387661
Therapy non-responder 57.75 9.57 160 290786 92145 79361297
Blood pressure systolic increased 56.88 9.57 98 290848 66888 79386554
Thinking abnormal 56.78 9.57 139 290807 13022 79440420
Anaemia 56.37 9.57 1216 289730 443799 79009643
Speech disorder 56.36 9.57 366 290580 54079 79399363
Postmortem blood drug level abnormal 56.07 9.57 33 290913 621 79452821
Pancytopenia 56.05 9.57 364 290582 165381 79288061
Hallucination, visual 55.65 9.57 252 290694 32477 79420965
Anhedonia 55.62 9.57 149 290797 14749 79438693
Vertigo 54.50 9.57 435 290511 68647 79384795
Hepatic function abnormal 54.18 9.57 116 290830 72991 79380451
Anticholinergic syndrome 53.53 9.57 66 290880 3545 79449897
Dysarthria 53.45 9.57 426 290520 67196 79386246
Cardiac failure 52.38 9.57 340 290606 154502 79298940
Respiratory acidosis 52.32 9.57 122 290824 11078 79442364
Delirium 52.28 9.57 505 290441 84122 79369320
Sedation 51.99 9.57 346 290600 51549 79401893
Obstructive airways disorder 51.69 9.57 25 290921 31434 79422008
Memory impairment 51.54 9.57 629 290317 111105 79342337
Feeling abnormal 50.49 9.57 839 290107 158360 79295082
Liver injury 49.76 9.57 81 290865 56533 79396909
Inflammation 48.49 9.57 177 290769 93576 79359866
Blood pressure diastolic decreased 48.16 9.57 25 290921 30191 79423251
Hip arthroplasty 48.12 9.57 36 290910 35720 79417722
Urinary retention 47.66 9.57 362 290584 56268 79397174
Asthma 47.57 9.57 293 290653 134802 79318640
Herpes zoster 46.67 9.57 178 290768 92905 79360537
Major depression 46.61 9.57 102 290844 8878 79444564
Sluggishness 46.55 9.57 85 290861 6487 79446955
Self-medication 46.42 9.57 74 290872 5058 79448384
Pulmonary congestion 46.33 9.57 209 290737 26891 79426551
Urticaria 45.77 9.57 443 290503 184758 79268684
Alcohol use 45.56 9.57 71 290875 4760 79448682
Emotional distress 45.30 9.57 275 290671 39694 79413748
Bone erosion 44.81 9.57 6 290940 17841 79435601
Blood creatinine increased 44.45 9.57 357 290589 154700 79298742
Inappropriate schedule of product administration 44.40 9.57 295 290651 133333 79320109
Prostate cancer 44.12 9.57 34 290912 33234 79420208
Drug hypersensitivity 44.10 9.57 796 290150 298120 79155322
Anger 43.67 9.57 150 290796 17012 79436430
Ascites 43.62 9.57 136 290810 75426 79378016
Pneumocystis jirovecii pneumonia 43.40 9.57 33 290913 32475 79420967
Live birth 43.23 9.57 8 290938 18736 79434706
Grip strength decreased 43.21 9.57 13 290933 21856 79431586
Bronchiectasis 42.99 9.57 14 290932 22372 79431070
Anaphylactic reaction 42.07 9.57 160 290786 83583 79369859
Haemoglobin decreased 41.71 9.57 565 290381 221554 79231888
Mania 41.68 9.57 154 290792 18106 79435336
Inadequate analgesia 40.85 9.57 66 290880 4563 79448879
Poverty of speech 40.77 9.57 26 290920 568 79452874
Liver disorder 39.95 9.57 133 290813 72284 79381158
Pruritus 39.95 9.57 1115 289831 393533 79059909
Transplant rejection 39.42 9.57 11 290935 19426 79434016
Alcohol poisoning 38.87 9.57 66 290880 4755 79448687
Panic disorder 38.54 9.57 51 290895 2941 79450501
Acute kidney injury 38.32 9.57 1528 289418 517876 78935566
Substance abuser 38.05 9.57 16 290930 139 79453303
Hallucinations, mixed 37.68 9.57 80 290866 6819 79446623
Body temperature decreased 37.61 9.57 37 290909 32108 79421334
Hallucination 37.10 9.57 477 290469 85268 79368174
Hypothermia 37.09 9.57 173 290773 22573 79430869
Drug withdrawal convulsions 36.89 9.57 43 290903 2177 79451265
Neurotoxicity 36.26 9.57 39 290907 32479 79420963
Multiple organ dysfunction syndrome 36.26 9.57 273 290673 119973 79333469
White blood cell count decreased 35.68 9.57 478 290468 187810 79265632
Stupor 35.60 9.57 78 290868 6794 79446648
Cytomegalovirus viraemia 35.54 9.57 3 290943 12818 79440624
Gastrointestinal haemorrhage 35.38 9.57 356 290590 147363 79306079
Fatigue 35.18 9.57 2918 288028 926809 78526633
Metastases to liver 35.00 9.57 31 290915 28283 79425159
Hallucination, auditory 34.93 9.57 159 290787 20534 79432908
Aplastic anaemia 34.74 9.57 11 290935 17894 79435548
Pneumonia aspiration 33.98 9.57 384 290562 66583 79386859
Blood pressure diastolic abnormal 33.52 9.57 14 290932 19188 79434254
Mental disorder 33.36 9.57 212 290734 31090 79422352
Red blood cell sedimentation rate increased 33.13 9.57 74 290872 45868 79407574
Prescription drug used without a prescription 33.04 9.57 56 290890 4029 79449413
Extrapyramidal disorder 33.03 9.57 167 290779 22512 79430930
Fear 32.80 9.57 163 290783 21823 79431619
Full blood count abnormal 32.75 9.57 61 290885 40413 79413029
Accidental poisoning 32.51 9.57 35 290911 1622 79451820
Tubulointerstitial nephritis 32.40 9.57 56 290890 38179 79415263
Venoocclusive liver disease 31.97 9.57 3 290943 11768 79441674
Productive cough 31.91 9.57 190 290756 88141 79365301
Persistent genital arousal disorder 31.77 9.57 17 290929 264 79453178
Exposure during pregnancy 31.74 9.57 227 290719 100905 79352537
Chemical submission 31.54 9.57 18 290928 319 79453123
Septic shock 31.50 9.57 291 290655 122510 79330932
Respiratory rate decreased 31.22 9.57 63 290883 5180 79448262
Osmolar gap increased 31.21 9.57 13 290933 110 79453332
Tenosynovitis 31.18 9.57 9 290937 15545 79437897
Suicidal behaviour 31.01 9.57 48 290898 3199 79450243
Gun shot wound 30.83 9.57 29 290917 1141 79452301
Hyperhidrosis 30.79 9.57 747 290199 150745 79302697
Diabetic ketoacidosis 30.76 9.57 48 290898 34074 79419368
Pain in extremity 30.75 9.57 1055 289891 363483 79089959
Hyporesponsive to stimuli 30.69 9.57 38 290908 2050 79451392
Abulia 30.23 9.57 27 290919 993 79452449
Manic symptom 30.14 9.57 13 290933 121 79453321
Cellulitis 29.93 9.57 254 290692 108806 79344636
Inappropriate antidiuretic hormone secretion 29.79 9.57 181 290765 26132 79427310
Psychomotor retardation 29.59 9.57 68 290878 6116 79447326
Angioedema 29.38 9.57 160 290786 75875 79377567
Blood test abnormal 29.21 9.57 14 290932 17696 79435746
Arthritis 29.13 9.57 273 290673 114607 79338835
Sleep disorder due to a general medical condition 29.11 9.57 8 290938 14269 79439173
Leukopenia 29.07 9.57 278 290668 116235 79337207
Narcotic bowel syndrome 29.04 9.57 16 290930 264 79453178
Haemorrhage 28.85 9.57 204 290742 90914 79362528
Fibromyalgia 28.53 9.57 129 290817 64211 79389231
Cytokine release syndrome 28.47 9.57 55 290891 35943 79417499
Drug-induced liver injury 28.47 9.57 134 290812 65983 79387459
Apathy 28.41 9.57 108 290838 12869 79440573
Multiple injuries 28.38 9.57 48 290898 3447 79449995
Dysphoria 28.33 9.57 57 290889 4677 79448765
Immobilisation prolonged 28.27 9.57 12 290934 107 79453335
Liver function test increased 27.92 9.57 65 290881 39708 79413734
Foot deformity 27.83 9.57 28 290918 24046 79429396
Cerebral haemorrhage 27.81 9.57 112 290834 57561 79395881
Impaired driving ability 27.53 9.57 61 290885 5354 79448088
Pleural effusion 27.43 9.57 369 290577 144893 79308549
Osteoarthritis 27.38 9.57 196 290750 87113 79366329
Adjustment disorder with mixed anxiety and depressed mood 27.33 9.57 12 290934 117 79453325
Medication error 27.26 9.57 376 290570 68266 79385176
Oesophageal carcinoma 27.19 9.57 4 290942 11080 79442362
Heart rate decreased 27.15 9.57 148 290798 70168 79383274
Cyanosis 27.12 9.57 171 290775 25011 79428431
Haematochezia 26.89 9.57 198 290748 87447 79365995
Haemophagocytic lymphohistiocytosis 26.88 9.57 24 290922 21813 79431629
Therapy partial responder 26.84 9.57 15 290931 17382 79436060
Appendicitis 26.64 9.57 22 290924 20772 79432670
Head injury 26.63 9.57 230 290716 37139 79416303
Cholecystitis chronic 26.46 9.57 88 290858 9818 79443624
Macular degeneration 26.40 9.57 96 290850 11200 79442242
Tumour lysis syndrome 26.37 9.57 29 290917 23910 79429532
Drug ineffective for unapproved indication 26.32 9.57 97 290849 51141 79402301
Road traffic accident 26.20 9.57 259 290687 43405 79410037
Aspergillus infection 26.16 9.57 19 290927 19142 79434300
Cardio-respiratory distress 26.08 9.57 15 290931 270 79453172
Distributive shock 26.05 9.57 40 290906 2647 79450795
Obsessive-compulsive disorder 25.99 9.57 63 290883 5864 79447578
Feeling jittery 25.79 9.57 104 290842 12737 79440705
Nephropathy toxic 25.67 9.57 22 290924 20397 79433045
Slow speech 25.60 9.57 38 290908 2440 79451002
Oropharyngeal pain 25.58 9.57 265 290681 109088 79344354
Hyperleukocytosis 25.51 9.57 39 290907 2571 79450871
Depressed mood 25.51 9.57 280 290666 48200 79405242
Anorgasmia 25.51 9.57 27 290919 1227 79452215
Wound infection 25.41 9.57 30 290916 23961 79429481
Breast cancer stage III 25.41 9.57 3 290943 9823 79443619
Catatonia 25.39 9.57 80 290866 8676 79444766
Bacteraemia 25.23 9.57 51 290895 32773 79420669
Premature delivery 25.23 9.57 29 290917 23438 79430004
Paramnesia 25.01 9.57 8 290938 28 79453414
Analgesic drug level increased 24.95 9.57 43 290903 3135 79450307
Withdrawal catatonia 24.87 9.57 13 290933 192 79453250
Poor venous access 24.77 9.57 18 290928 18131 79435311
Blood pressure diastolic increased 24.75 9.57 11 290935 14531 79438911
Suspected counterfeit product 24.65 9.57 19 290927 567 79452875
Enthesopathy 24.63 9.57 6 290940 11602 79441840
Generalised anxiety disorder 24.61 9.57 35 290911 2162 79451280
Bronchopulmonary aspergillosis 24.57 9.57 27 290919 22267 79431175
Rhabdomyolysis 24.54 9.57 520 290426 102611 79350831
Toxic epidermal necrolysis 24.50 9.57 82 290864 44499 79408943
Joint range of motion decreased 24.50 9.57 53 290893 33229 79420213
Joint effusion 24.42 9.57 18 290928 17996 79435446
Diffuse large B-cell lymphoma 24.41 9.57 7 290939 12142 79441300
Procedural pain 24.39 9.57 156 290790 22928 79430514
Pathogen resistance 24.17 9.57 11 290935 14331 79439111
Bone marrow failure 24.17 9.57 100 290846 51007 79402435
Obsessive thoughts 24.15 9.57 25 290921 1107 79452335
Osteonecrosis of jaw 24.11 9.57 79 290867 43147 79410295
Parkinsonism 24.07 9.57 122 290824 16462 79436980
Adrenal insufficiency 23.89 9.57 42 290904 28445 79424997
Nightmare 23.87 9.57 169 290777 25692 79427750
Hypervolaemia 23.82 9.57 78 290868 42612 79410830
Blood lactate dehydrogenase increased 23.68 9.57 69 290877 39101 79414341
Homicidal ideation 23.59 9.57 44 290902 3413 79450029
Housebound 23.52 9.57 17 290929 459 79452983
Delusion 23.45 9.57 141 290805 20282 79433160
Alanine aminotransferase increased 23.30 9.57 435 290511 162135 79291307
Benzodiazepine drug level abnormal 23.09 9.57 5 290941 0 79453442
Stevens-Johnson syndrome 22.95 9.57 70 290876 39096 79414346
Restlessness 22.87 9.57 265 290681 46227 79407215
Adverse drug reaction 22.84 9.57 145 290801 66247 79387195
Hallucination, gustatory 22.83 9.57 9 290937 65 79453377
Ankylosing spondylitis 22.80 9.57 8 290938 12197 79441245
Lip swelling 22.66 9.57 75 290871 40836 79412606
Pulmonary oedema 22.64 9.57 450 290496 87804 79365638
Blood bilirubin increased 22.61 9.57 145 290801 66087 79387355
Joint stiffness 22.51 9.57 75 290871 40755 79412687
Substance use 22.44 9.57 22 290924 912 79452530
Wrong patient received product 22.34 9.57 51 290895 4567 79448875
Myoclonus 22.26 9.57 175 290771 27485 79425957
Upper gastrointestinal haemorrhage 22.14 9.57 77 290869 41303 79412139
Oedema 22.13 9.57 305 290641 119275 79334167
Multiple-drug resistance 22.02 9.57 3 290943 8805 79444637
Electrocardiogram QRS complex prolonged 21.97 9.57 88 290858 10745 79442697
Feeling of despair 21.93 9.57 38 290908 2783 79450659
Facet joint syndrome 21.82 9.57 7 290939 11295 79442147
Clostridium difficile infection 21.80 9.57 81 290865 42604 79410838
Haematotoxicity 21.70 9.57 15 290931 15504 79437938
Mood altered 21.64 9.57 125 290821 17722 79435720
Pulmonary toxicity 21.62 9.57 10 290936 12904 79440538
Epstein-Barr virus infection 21.43 9.57 13 290933 14403 79439039
Peripheral venous disease 21.43 9.57 16 290930 15893 79437549
Lip dry 21.43 9.57 15 290931 15403 79438039
Uveitis 21.32 9.57 18 290928 16812 79436630
Interstitial lung disease 21.27 9.57 286 290660 112314 79341128
Pregnancy 21.26 9.57 41 290905 26810 79426632
Blood pressure systolic abnormal 21.18 9.57 19 290927 17228 79436214
Drug tolerance increased 21.17 9.57 18 290928 619 79452823
Hyponatraemic encephalopathy 21.17 9.57 14 290932 326 79453116
Exposure via inhalation 21.11 9.57 10 290936 118 79453324
Liver function test abnormal 21.07 9.57 143 290803 64332 79389110
Dissociative disorder 20.97 9.57 20 290926 801 79452641
Self-injurious ideation 20.82 9.57 43 290903 3595 79449847
Tension 20.60 9.57 48 290898 4356 79449086
Hospitalisation 20.58 9.57 232 290714 94004 79359438
Subarachnoid haemorrhage 20.58 9.57 36 290910 24429 79429013
Vestibular ischaemia 20.53 9.57 6 290940 14 79453428
Acute myeloid leukaemia 20.48 9.57 52 290894 30833 79422609
Substance dependence 20.45 9.57 16 290930 488 79452954
Renal papillary necrosis 20.44 9.57 15 290931 415 79453027
Hepatotoxicity 20.43 9.57 107 290839 51245 79402197
Puncture site haematoma 20.38 9.57 11 290935 174 79453268
Hypersomnia 20.23 9.57 149 290797 22937 79430505
Apraxia 20.21 9.57 37 290909 2830 79450612
Wrong patient 20.17 9.57 14 290932 354 79453088
Lymphadenopathy 20.05 9.57 113 290833 53134 79400308
Therapeutic response decreased 20.04 9.57 152 290794 66701 79386741
Leukoencephalopathy 19.91 9.57 69 290877 7860 79445582
Conversion disorder 19.90 9.57 29 290917 1832 79451610
Hypocalcaemia 19.87 9.57 104 290842 49820 79403622
Cutaneous T-cell dyscrasia 19.81 9.57 8 290938 62 79453380
Hypochloraemia 19.71 9.57 34 290912 2481 79450961
Type 2 diabetes mellitus 19.52 9.57 125 290821 56997 79396445
Prothrombin time shortened 19.48 9.57 39 290907 3189 79450253
Thermal burn 19.47 9.57 64 290882 7096 79446346
Acquired amegakaryocytic thrombocytopenia 19.45 9.57 6 290940 18 79453424
Hyperreflexia 19.37 9.57 71 290875 8314 79445128
Purging 19.28 9.57 7 290939 39 79453403
Sputum discoloured 19.21 9.57 31 290915 21712 79431730
Vaginal flatulence 19.13 9.57 34 290912 2541 79450901
Influenza 19.13 9.57 345 290601 129261 79324181
Bladder cancer 19.04 9.57 26 290920 19500 79433942
Chronic fatigue syndrome 18.98 9.57 24 290922 1323 79452119
Adverse event 18.97 9.57 135 290811 60079 79393363
Respiratory failure 18.82 9.57 509 290437 180402 79273040
Partner stress 18.78 9.57 13 290933 327 79453115
Drug diversion 18.78 9.57 23 290923 1227 79452215
Rhinorrhoea 18.76 9.57 182 290764 75892 79377550
Forced expiratory volume decreased 18.76 9.57 3 290943 7811 79445631
Logorrhoea 18.72 9.57 46 290900 4319 79449123
Reduced facial expression 18.63 9.57 35 290911 2730 79450712
Body temperature increased 18.55 9.57 91 290855 44329 79409113
Pain 18.51 9.57 2267 288679 701535 78751907
Autoimmune disorder 18.44 9.57 20 290926 16592 79436850
Brachial plexus injury 18.44 9.57 9 290937 114 79453328
Cholangitis 18.33 9.57 12 290934 12764 79440678
Tonic clonic movements 18.26 9.57 31 290915 2233 79451209
Skin ulcer 18.25 9.57 119 290827 54031 79399411
Prothrombin level decreased 18.13 9.57 26 290920 1618 79451824
Blood alcohol increased 18.13 9.57 23 290923 1272 79452170
Cardiac valve disease 18.09 9.57 54 290892 5687 79447755
Alanine aminotransferase abnormal 18.02 9.57 5 290941 8862 79444580
Multiple sclerosis 17.95 9.57 141 290805 22141 79431301
Necrosis ischaemic 17.92 9.57 21 290925 1069 79452373
Metastases to lung 17.90 9.57 24 290922 18139 79435303
Affect lability 17.89 9.57 85 290861 11174 79442268
Dermatitis allergic 17.82 9.57 24 290922 18106 79435336
Loss of personal independence in daily activities 17.80 9.57 265 290681 102315 79351127
Brain oedema 17.74 9.57 155 290791 25108 79428334
Incoherent 17.66 9.57 65 290881 7627 79445815
Foetal death 17.66 9.57 67 290879 7977 79445465
Morbid thoughts 17.63 9.57 18 290928 784 79452658
Neuropathy peripheral 17.58 9.57 387 290559 140918 79312524
Sinus tachycardia 17.54 9.57 209 290737 36699 79416743
Injection site pain 17.50 9.57 351 290595 129487 79323955
Second primary malignancy 17.39 9.57 16 290930 14334 79439108
Mental status changes 17.37 9.57 342 290604 66617 79386825
Muscular weakness 17.30 9.57 450 290496 160279 79293163
Injection site erythema 17.27 9.57 192 290754 78005 79375437
Sinus bradycardia 17.27 9.57 154 290792 25093 79428349
Drug withdrawal maintenance therapy 17.25 9.57 7 290939 55 79453387
Drug tolerance 17.22 9.57 70 290876 8605 79444837
Nasal polyps 17.17 9.57 3 290943 7324 79446118
Compartment syndrome 17.16 9.57 49 290897 5033 79448409
Myelodysplastic syndrome 17.16 9.57 55 290891 30246 79423196
Arthritis bacterial 17.14 9.57 6 290940 9160 79444282
Laryngeal injury 17.01 9.57 5 290941 12 79453430
Mouth ulceration 17.01 9.57 77 290869 38317 79415125
Bipolar I disorder 16.97 9.57 29 290917 2100 79451342
Anamnestic reaction 16.90 9.57 6 290940 31 79453411
Cataract 16.89 9.57 145 290801 61975 79391467
Creatinine renal clearance decreased 16.87 9.57 27 290919 18975 79434467
Bradycardia 16.84 9.57 629 290317 134928 79318514
Blood cholesterol increased 16.78 9.57 210 290736 83510 79369932
Bacterial prostatitis 16.73 9.57 7 290939 60 79453382
Hyperthermia 16.72 9.57 118 290828 17919 79435523
Feeling of relaxation 16.64 9.57 9 290937 143 79453299
Squamous cell carcinoma of skin 16.59 9.57 16 290930 14017 79439425
Mixed anxiety and depressive disorder 16.52 9.57 13 290933 400 79453042
Learning disorder 16.52 9.57 15 290931 564 79452878
Hypervigilance 16.38 9.57 14 290932 485 79452957
Somnambulism 16.34 9.57 52 290894 5669 79447773
Localised infection 16.26 9.57 76 290870 37499 79415943
Femur fracture 16.25 9.57 79 290867 38573 79414869
LDL/HDL ratio increased 16.24 9.57 4 290942 3 79453439
Papillary muscle disorder 16.24 9.57 4 290942 3 79453439
Acute graft versus host disease in skin 16.17 9.57 4 290942 7654 79445788
Thrombocytopenia 16.10 9.57 797 290149 264462 79188980
BK virus infection 16.06 9.57 6 290940 8798 79444644
Self esteem decreased 15.97 9.57 19 290927 983 79452459
Bladder dilatation 15.77 9.57 28 290918 2091 79451351
Dyssomnia 15.63 9.57 6 290940 40 79453402
Cerebral infarction 15.58 9.57 100 290846 45576 79407866
Polyarthritis 15.52 9.57 13 290933 12189 79441253
Cystitis haemorrhagic 15.51 9.57 7 290939 9165 79444277
Tarsal tunnel syndrome 15.51 9.57 14 290932 522 79452920
Sarcomatoid carcinoma 15.50 9.57 6 290940 41 79453401
Feeling drunk 15.45 9.57 45 290901 4674 79448768
Gambling disorder 15.37 9.57 27 290919 1999 79451443
Electrocardiogram QRS complex shortened 15.35 9.57 16 290930 714 79452728
Dyskinesia 15.31 9.57 239 290707 44534 79408908
Product complaint 15.22 9.57 92 290854 13257 79440185
COVID-19 pneumonia 15.22 9.57 54 290892 28795 79424647
Disinhibition 15.21 9.57 31 290915 2567 79450875
Burning mouth syndrome 15.14 9.57 14 290932 539 79452903
Tendonitis 15.13 9.57 41 290905 23789 79429653
Refusal of treatment by patient 15.11 9.57 69 290877 8922 79444520
Faecal disimpaction 15.11 9.57 5 290941 20 79453422
Drug screen negative 15.09 9.57 11 290935 301 79453141
Cushingoid 15.08 9.57 8 290938 9544 79443898
Encephalitis 15.06 9.57 19 290927 14741 79438701
Emotional disorder 15.06 9.57 97 290849 14290 79439152
Abdominal pain 15.06 9.57 1220 289726 388349 79065093
Lupus-like syndrome 15.03 9.57 17 290929 13840 79439602
Fistula 15.01 9.57 15 290931 12925 79440517
Pulmonary tuberculosis 14.96 9.57 5 290941 7860 79445582
Pneumonia bacterial 14.89 9.57 30 290916 19301 79434141
Cholestasis 14.84 9.57 270 290676 51839 79401603
Tachycardia 14.84 9.57 792 290154 176976 79276466
Tobacco user 14.83 9.57 16 290930 743 79452699
Negativism 14.82 9.57 17 290929 846 79452596
Graft versus host disease 14.66 9.57 20 290926 15006 79438436
Victim of crime 14.63 9.57 13 290933 475 79452967
Product substitution issue 14.60 9.57 125 290821 20131 79433311
Initial insomnia 14.58 9.57 57 290889 6881 79446561
Eosinophil count increased 14.54 9.57 25 290921 17080 79436362
Incision site pain 14.52 9.57 32 290914 2798 79450644
Blood triglycerides abnormal 14.51 9.57 13 290933 480 79452962
Osteoporosis 14.41 9.57 127 290819 53985 79399457
Atrial fibrillation 14.36 9.57 583 290363 197303 79256139
Bipolar disorder 14.36 9.57 61 290885 7646 79445796
Contusion 14.34 9.57 423 290523 148353 79305089
Neoplasm progression 14.34 9.57 120 290826 51562 79401880
Musculoskeletal disorder 14.30 9.57 36 290910 21412 79432030
Throat irritation 14.30 9.57 89 290857 40857 79412585
Accident 14.27 9.57 67 290879 8764 79444678
Alcohol withdrawal syndrome 14.23 9.57 26 290920 1985 79451457
Needle issue 14.21 9.57 16 290930 13052 79440390
Yawning 14.19 9.57 21 290925 1345 79452097
Pneumatosis intestinalis 14.19 9.57 3 290943 6394 79447048
Generalised tonic-clonic seizure 14.12 9.57 232 290714 43678 79409764
Meningioma 14.09 9.57 41 290905 4257 79449185
Paraesthesia oral 14.07 9.57 125 290821 20346 79433096
Pneumonitis 14.02 9.57 148 290798 60712 79392730
Osteonecrosis 13.99 9.57 62 290884 31033 79422409
Libido decreased 13.97 9.57 47 290899 5274 79448168
Angina pectoris 13.96 9.57 121 290825 51611 79401831
Hypersensitivity vasculitis 13.95 9.57 4 290942 6939 79446503
Weight increased 13.95 9.57 849 290097 276537 79176905
Multiple sclerosis relapse 13.92 9.57 243 290703 46290 79407152
Product quality issue 13.92 9.57 187 290759 33753 79419689
Amimia 13.90 9.57 6 290940 56 79453386
Panic reaction 13.87 9.57 43 290903 4622 79448820
Tracheobronchitis bacterial 13.85 9.57 3 290943 0 79453442
Bone density decreased 13.81 9.57 17 290929 13330 79440112
Fear of injection 13.79 9.57 5 290941 7469 79445973
Hyperinsulinism 13.79 9.57 4 290942 9 79453433
Formication 13.75 9.57 45 290901 4978 79448464
Hepatic cirrhosis 13.73 9.57 73 290873 34833 79418609
Drug dose omission by device 13.72 9.57 3 290943 6247 79447195
Cerebral congestion 13.71 9.57 6 290940 58 79453384
Alcoholism 13.66 9.57 37 290909 3686 79449756
Mean cell haemoglobin decreased 13.64 9.57 3 290943 6221 79447221
Cerebral microangiopathy 13.61 9.57 10 290936 277 79453165
Drug eruption 13.59 9.57 99 290847 43836 79409606
Haemolysis 13.59 9.57 16 290930 12796 79440646
Hyperacusis 13.58 9.57 27 290919 2196 79451246
Coma scale 13.53 9.57 6 290940 60 79453382
Hepatic cytolysis 13.46 9.57 155 290791 26996 79426446
Hyponatraemia 13.41 9.57 785 290161 177063 79276379
Device related infection 13.34 9.57 72 290874 34222 79419220
Proteinuria 13.34 9.57 67 290879 32435 79421007
Maximal voluntary ventilation abnormal 13.33 9.57 5 290941 31 79453411
Thymus disorder 13.31 9.57 10 290936 287 79453155
Hypertonia 13.29 9.57 57 290889 7175 79446267
Abnormal dreams 13.24 9.57 79 290867 11333 79442109
Palmar-plantar erythrodysaesthesia syndrome 13.20 9.57 69 290877 33065 79420377
Graft versus host disease in skin 13.16 9.57 3 290943 6070 79447372
Blood triglycerides decreased 13.16 9.57 9 290937 222 79453220
Hypercapnia 13.16 9.57 66 290880 8869 79444573
Burning sensation 13.10 9.57 293 290653 58339 79395103
Paranoia 13.02 9.57 118 290828 19314 79434128
Jaundice 13.00 9.57 128 290818 53221 79400221
Foreign body 12.95 9.57 31 290915 2863 79450579
Physical assault 12.92 9.57 22 290924 1589 79451853
Nephrotic syndrome 12.91 9.57 13 290933 11161 79442281
Wrong rate 12.88 9.57 6 290940 68 79453374
Vestibular disorder 12.87 9.57 28 290918 2427 79451015
Injection site swelling 12.82 9.57 110 290836 47022 79406420
Hypotension 12.81 9.57 1813 289133 438504 79014938
Cognitive disorder 12.78 9.57 340 290606 69586 79383856
Osteomyelitis 12.78 9.57 69 290877 32796 79420646
Cytomegalovirus test positive 12.76 9.57 3 290943 5944 79447498
Gastric cancer 12.76 9.57 11 290935 10168 79443274
Legal problem 12.74 9.57 8 290938 170 79453272
Cholecystectomy 12.73 9.57 68 290878 9364 79444078
Abdominal pain upper 12.71 9.57 677 290269 223142 79230300
Metastases to bone 12.70 9.57 46 290900 24381 79429061
Chloasma 12.70 9.57 5 290941 36 79453406
Feeling hot 12.67 9.57 148 290798 59586 79393856
Basal cell carcinoma 12.66 9.57 82 290864 37293 79416149
Large intestine perforation 12.65 9.57 21 290925 14546 79438896
Blood pressure increased 12.63 9.57 636 290310 210724 79242718
Nodular rash 12.62 9.57 10 290936 311 79453131
Myopathy 12.59 9.57 36 290910 20527 79432915
Pneumoconiosis 12.58 9.57 9 290937 239 79453203
Colorectal cancer 12.57 9.57 8 290938 8639 79444803
Substance-induced mood disorder 12.57 9.57 7 290939 118 79453324
Electroencephalogram abnormal 12.54 9.57 46 290900 5388 79448054
Immunosuppression 12.53 9.57 17 290929 12786 79440656
Atrioventricular block 12.52 9.57 91 290855 13950 79439492
Pulmonary alveolar haemorrhage 12.49 9.57 14 290932 11443 79441999
Ligament sprain 12.43 9.57 88 290858 13376 79440066
Cardiomegaly 12.43 9.57 149 290797 26203 79427239
Disease recurrence 12.43 9.57 102 290844 44007 79409435
Vaginal discharge 12.34 9.57 57 290889 7406 79446036
Torsade de pointes 12.30 9.57 116 290830 19196 79434246
Peripheral nerve paresis 12.25 9.57 5 290941 40 79453402
Tubulointerstitial nephritis and uveitis syndrome 12.24 9.57 10 290936 325 79453117
Brain death 12.23 9.57 47 290899 5630 79447812
Oesophagitis chemical 12.15 9.57 6 290940 78 79453364
Judgement impaired 12.11 9.57 19 290927 1281 79452161
Sickle cell anaemia with crisis 11.98 9.57 7 290939 7915 79445527
Musculoskeletal pain 11.97 9.57 283 290663 102071 79351371
Growth hormone deficiency 11.97 9.57 11 290935 420 79453022
Cutaneous lymphoma 11.96 9.57 9 290937 259 79453183
Intrusive thoughts 11.95 9.57 12 290934 512 79452930
Anxiety disorder 11.91 9.57 38 290908 4149 79449293
Hypokalaemia 11.87 9.57 641 290305 143399 79310043
Hair texture abnormal 11.86 9.57 34 290912 3500 79449942
Skin plaque 11.86 9.57 13 290933 10732 79442710
Blood uric acid increased 11.85 9.57 19 290927 13341 79440101
Inflammatory marker increased 11.84 9.57 13 290933 10727 79442715
Chemical poisoning 11.81 9.57 8 290938 194 79453248
Victim of sexual abuse 11.80 9.57 12 290934 520 79452922
Respiratory tract infection 11.79 9.57 117 290829 48572 79404870
Faeces soft 11.70 9.57 8 290938 8315 79445127
Aplasia pure red cell 11.67 9.57 7 290939 7803 79445639
Product solubility abnormal 11.65 9.57 16 290930 956 79452486
Periorbital haematoma 11.63 9.57 16 290930 958 79452484
Femoral artery aneurysm 11.60 9.57 8 290938 200 79453242
Vascular purpura 11.58 9.57 31 290915 3067 79450375
Foaming at mouth 11.54 9.57 23 290923 1874 79451568
Gastric infection 11.54 9.57 35 290911 3718 79449724
Suspiciousness 11.54 9.57 13 290933 634 79452808
Pulmonary fibrosis 11.54 9.57 104 290842 44008 79409434
Dysuria 11.50 9.57 255 290691 50696 79402746
Product substitution 11.46 9.57 6 290940 89 79453353
Red cell distribution width increased 11.44 9.57 24 290922 15218 79438224
Anion gap abnormal 11.44 9.57 13 290933 640 79452802
Seizure 11.42 9.57 818 290128 188016 79265426
Sudden death 11.38 9.57 129 290817 22382 79431060
Chronic sinusitis 11.37 9.57 84 290862 12942 79440500
Vascular headache 11.37 9.57 5 290941 49 79453393
Vasculitis 11.33 9.57 50 290896 25052 79428390
Deformity 11.30 9.57 11 290935 9594 79443848
Proctitis 11.29 9.57 50 290896 6382 79447060
Epistaxis 11.27 9.57 315 290631 111200 79342242
Cyclothymic disorder 11.26 9.57 8 290938 210 79453232
Red blood cell count decreased 11.25 9.57 145 290801 57368 79396074
Hepatitis acute 11.25 9.57 96 290850 15446 79437996
Central nervous system necrosis 11.24 9.57 9 290937 284 79453158
Disability 11.21 9.57 29 290917 17091 79436351
Myocardial infarction 11.21 9.57 553 290393 183576 79269866
Face injury 11.11 9.57 34 290912 3630 79449812
Biliary dyskinesia 11.11 9.57 27 290919 2518 79450924
Therapeutic response shortened 11.07 9.57 26 290920 15837 79437605
Cystitis 11.05 9.57 131 290815 52601 79400841
Peripheral circulatory failure 11.03 9.57 17 290929 1129 79452313
Muscle rigidity 11 9.57 116 290830 19766 79433676
Post-traumatic stress disorder 11 9.57 41 290905 4840 79448602
Hypophagia 10.99 9.57 109 290837 45258 79408184
Sinus arrhythmia 10.99 9.57 24 290922 2086 79451356
Hypoxic-ischaemic encephalopathy 10.98 9.57 57 290889 7763 79445679
Blood creatine phosphokinase 10.93 9.57 7 290939 154 79453288
Muscle spasms 10.93 9.57 759 290187 173971 79279471
Neuroglycopenia 10.89 9.57 11 290935 473 79452969
Pericardial effusion 10.83 9.57 112 290834 46125 79407317
Impulsive behaviour 10.82 9.57 29 290917 2871 79450571
Oesophageal food impaction 10.81 9.57 10 290936 385 79453057
Hallucination, olfactory 10.81 9.57 11 290935 477 79452965
Oedematous pancreatitis 10.78 9.57 17 290929 1151 79452291
Acute myocardial infarction 10.76 9.57 207 290739 76829 79376613
Device malfunction 10.75 9.57 41 290905 21407 79432035
Infective pulmonary exacerbation of cystic fibrosis 10.73 9.57 19 290927 12832 79440610
Rhinovirus infection 10.71 9.57 8 290938 7945 79445497
Vagus nerve disorder 10.71 9.57 5 290941 57 79453385
Sciatica 10.70 9.57 74 290872 33148 79420294
Benzodiazepine drug level increased 10.69 9.57 8 290938 228 79453214
Anal fistula 10.69 9.57 6 290940 6938 79446504
Sedation complication 10.68 9.57 26 290920 15643 79437799
Tremor neonatal 10.58 9.57 3 290943 6 79453436
Benign mesenteric neoplasm 10.58 9.57 3 290943 6 79453436
Progressive multifocal leukoencephalopathy 10.58 9.57 39 290907 20561 79432881
Nephrolithiasis 10.56 9.57 134 290812 53157 79400285
Conjunctivitis 10.56 9.57 53 290893 25662 79427780
X-ray abnormal 10.54 9.57 4 290942 5809 79447633
Retrograde amnesia 10.53 9.57 12 290934 593 79452849
Labelled drug-food interaction medication error 10.51 9.57 7 290939 165 79453277
Myotonia 10.49 9.57 8 290938 235 79453207
Injury 10.46 9.57 363 290583 77133 79376309
Anion gap 10.45 9.57 24 290922 2157 79451285
Electrocardiogram ST-T change 10.39 9.57 20 290926 1589 79451853
Thermal burns of eye 10.38 9.57 6 290940 109 79453333
Vasoplegia syndrome 10.37 9.57 33 290913 3597 79449845
Visceral congestion 10.37 9.57 15 290931 941 79452501
Polyneuropathy 10.36 9.57 49 290897 24102 79429340
Pre-existing condition improved 10.34 9.57 44 290902 5519 79447923
Erythrodermic psoriasis 10.32 9.57 21 290925 1737 79451705
Uterine perforation 10.32 9.57 48 290898 6255 79447187
Intestinal perforation 10.31 9.57 31 290915 17395 79436047
Immune thrombocytopenia 10.31 9.57 32 290914 17773 79435669
Victim of homicide 10.29 9.57 7 290939 171 79453271
Skin abrasion 10.21 9.57 84 290862 13372 79440070
Pneumonia viral 10.19 9.57 11 290935 9147 79444295
Deafness neurosensory 10.19 9.57 51 290895 6847 79446595
Rales 10.18 9.57 38 290908 19963 79433479
Death of relative 10.17 9.57 8 290938 246 79453196
Nocardiosis 10.14 9.57 4 290942 5675 79447767
Bundle branch block right 10.08 9.57 73 290873 11178 79442264
Proctalgia 10.07 9.57 13 290933 9988 79443454
Purpura senile 10.06 9.57 11 290935 519 79452923
Coma scale abnormal 10.02 9.57 60 290886 8618 79444824
Swollen tongue 10.02 9.57 103 290843 42467 79410975
Ear infection 9.98 9.57 79 290867 34353 79419089
Metastases to lymph nodes 9.98 9.57 14 290932 10383 79443059
Phobia 9.98 9.57 10 290936 426 79453016
Sepsis syndrome 9.97 9.57 19 290927 1498 79451944
Beta haemolytic streptococcal infection 9.97 9.57 23 290923 2074 79451368
Enterocolitis 9.96 9.57 24 290922 14488 79438954
Skin reaction 9.94 9.57 28 290918 16040 79437402
Lung neoplasm malignant 9.92 9.57 60 290886 27732 79425710
Language disorder 9.91 9.57 30 290916 3184 79450258
Enterococcal infection 9.90 9.57 27 290919 15633 79437809
Laryngitis 9.88 9.57 28 290918 16011 79437431
Crime 9.86 9.57 5 290941 69 79453373
Gallbladder disorder 9.85 9.57 111 290835 19229 79434213
Thrombotic microangiopathy 9.83 9.57 39 290907 20130 79433312
Tongue biting 9.79 9.57 23 290923 2098 79451344
Methaemoglobinaemia 9.78 9.57 4 290942 5553 79447889
Haematemesis 9.77 9.57 133 290813 52131 79401311
Gallbladder hypofunction 9.77 9.57 11 290935 536 79452906
Faecal calprotectin increased 9.74 9.57 4 290942 5537 79447905
Carotid pulse abnormal 9.73 9.57 3 290943 9 79453433
Blood calcium decreased 9.70 9.57 72 290874 31747 79421695
Normal newborn 9.67 9.57 7 290939 7065 79446377
Prothrombin level increased 9.65 9.57 10 290936 443 79452999
Akathisia 9.65 9.57 82 290864 13177 79440265
Photophobia 9.65 9.57 116 290830 20412 79433030
Brain abscess 9.63 9.57 3 290943 4933 79448509
Performance status decreased 9.60 9.57 46 290900 6067 79447375
Staphylococcal sepsis 9.60 9.57 25 290921 14701 79438741

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N05BA12 NERVOUS SYSTEM
PSYCHOLEPTICS
ANXIOLYTICS
Benzodiazepine derivatives
FDA CS M0002356 Benzodiazepines
CHEBI has role CHEBI:35474 anti-anxiety agents
CHEBI has role CHEBI:35623 anticonvulsants
CHEBI has role CHEBI:35703 Xenobiotic
CHEBI has role CHEBI:35717 hypnotics
CHEBI has role CHEBI:51371 muscle relaxants
CHEBI has role CHEBI:51373 gamma-aminobutyric acid receptor agonist
MeSH PA D014151 Anti-Anxiety Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D018682 GABA Agents
MeSH PA D018757 GABA Modulators
MeSH PA D006993 Hypnotics and Sedatives
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D011619 Psychotropic Drugs
MeSH PA D014149 Tranquilizing Agents
FDA EPC N0000175694 Benzodiazepine

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Generalized anxiety disorder indication 21897009 DOID:14320
Anxiety indication 48694002
Mixed anxiety and depressive disorder indication 231504006
Panic disorder indication 371631005 DOID:594
Insomnia off-label use 193462001
Suicidal thoughts contraindication 6471006
Asthenia contraindication 13791008
Alcohol intoxication contraindication 25702006
Depressive disorder contraindication 35489007
Substance abuse contraindication 66214007
Sleep apnea contraindication 73430006 DOID:0050847
Open-angle glaucoma contraindication 84494001 DOID:1067
Kidney disease contraindication 90708001 DOID:557
Disease of liver contraindication 235856003 DOID:409
Syncope contraindication 271594007
Pregnancy, function contraindication 289908002
Angle-closure glaucoma contraindication 392291006 DOID:13550
Breastfeeding (mother) contraindication 413712001
Chronic lung disease contraindication 413839001
Obesity contraindication 414916001 DOID:9970
Central nervous system depression contraindication 418072004
Smokes tobacco daily contraindication 449868002




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 6.15 Basic
pKa2 4.9 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
GABA-A receptor alpha-5/beta-3/gamma-2 Ion channel POSITIVE ALLOSTERIC MODULATOR EC50 8 WOMBAT-PK CHEMBL
GABA-A receptor alpha-1/beta-2/gamma-2 Ion channel POSITIVE ALLOSTERIC MODULATOR EC50 7.43 WOMBAT-PK CHEMBL
GABA-A receptor alpha-2/beta-3/gamma-2 Ion channel POSITIVE ALLOSTERIC MODULATOR EC50 7.92 WOMBAT-PK CHEMBL
GABA-A receptor alpha-3/beta-3/gamma-2 Ion channel POSITIVE ALLOSTERIC MODULATOR EC50 7.16 WOMBAT-PK CHEMBL
Cytochrome P450 3A4 Enzyme Ki 3.85 WOMBAT-PK
Platelet-activating factor receptor GPCR Ki 5.46 PDSP
Bromodomain-containing protein 4 Unclassified Kd 5.61 CHEMBL
Cholecystokinin receptor type A GPCR IC50 4.19 CHEMBL

External reference:

IDSource
D00225 KEGG_DRUG
202363 RXNORM
C0002333 UMLSCUI
CHEBI:2611 CHEBI
08H PDB_CHEM_ID
CHEMBL661 ChEMBL_ID
DB00404 DRUGBANK_ID
D000525 MESH_DESCRIPTOR_UI
2118 PUBCHEM_CID
7111 IUPHAR_LIGAND_ID
3426 INN_ID
YU55MQ3IZY UNII
111127002 SNOMEDCT_US
386983007 SNOMEDCT_US
4018074 VANDF
1327 MMSL
1885 MMSL
4153 MMSL
d00168 MMSL
001464 NDDF

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Xanax HUMAN PRESCRIPTION DRUG LABEL 1 0009-0029 TABLET 0.25 mg ORAL NDA 37 sections
Xanax HUMAN PRESCRIPTION DRUG LABEL 1 0009-0029 TABLET 0.25 mg ORAL NDA 37 sections
Xanax HUMAN PRESCRIPTION DRUG LABEL 1 0009-0055 TABLET 0.50 mg ORAL NDA 37 sections
Xanax HUMAN PRESCRIPTION DRUG LABEL 1 0009-0055 TABLET 0.50 mg ORAL NDA 37 sections
Xanax XR HUMAN PRESCRIPTION DRUG LABEL 1 0009-0057 TABLET, EXTENDED RELEASE 0.50 mg ORAL NDA 38 sections
Xanax XR HUMAN PRESCRIPTION DRUG LABEL 1 0009-0057 TABLET, EXTENDED RELEASE 0.50 mg ORAL NDA 38 sections
Xanax XR HUMAN PRESCRIPTION DRUG LABEL 1 0009-0057 TABLET, EXTENDED RELEASE 0.50 mg ORAL NDA 38 sections
Xanax XR HUMAN PRESCRIPTION DRUG LABEL 1 0009-0059 TABLET, EXTENDED RELEASE 1 mg ORAL NDA 38 sections
Xanax XR HUMAN PRESCRIPTION DRUG LABEL 1 0009-0059 TABLET, EXTENDED RELEASE 1 mg ORAL NDA 38 sections
Xanax XR HUMAN PRESCRIPTION DRUG LABEL 1 0009-0059 TABLET, EXTENDED RELEASE 1 mg ORAL NDA 38 sections
Xanax XR HUMAN PRESCRIPTION DRUG LABEL 1 0009-0066 TABLET, EXTENDED RELEASE 2 mg ORAL NDA 38 sections
Xanax XR HUMAN PRESCRIPTION DRUG LABEL 1 0009-0066 TABLET, EXTENDED RELEASE 2 mg ORAL NDA 38 sections
Xanax XR HUMAN PRESCRIPTION DRUG LABEL 1 0009-0066 TABLET, EXTENDED RELEASE 2 mg ORAL NDA 38 sections
Xanax XR HUMAN PRESCRIPTION DRUG LABEL 1 0009-0068 TABLET, EXTENDED RELEASE 3 mg ORAL NDA 38 sections
Xanax XR HUMAN PRESCRIPTION DRUG LABEL 1 0009-0068 TABLET, EXTENDED RELEASE 3 mg ORAL NDA 38 sections
Xanax XR HUMAN PRESCRIPTION DRUG LABEL 1 0009-0068 TABLET, EXTENDED RELEASE 3 mg ORAL NDA 38 sections
Xanax HUMAN PRESCRIPTION DRUG LABEL 1 0009-0090 TABLET 1 mg ORAL NDA 37 sections
Xanax HUMAN PRESCRIPTION DRUG LABEL 1 0009-0090 TABLET 1 mg ORAL NDA 37 sections
Xanax HUMAN PRESCRIPTION DRUG LABEL 1 0009-0094 TABLET 2 mg ORAL NDA 37 sections
Xanax HUMAN PRESCRIPTION DRUG LABEL 1 0009-0094 TABLET 2 mg ORAL NDA 37 sections
Alprazolam HUMAN PRESCRIPTION DRUG LABEL 1 0054-3068 SOLUTION, CONCENTRATE 1 mg ORAL ANDA 34 sections
Alprazolam HUMAN PRESCRIPTION DRUG LABEL 1 0054-3068 SOLUTION, CONCENTRATE 1 mg ORAL ANDA 34 sections
Alprazolam HUMAN PRESCRIPTION DRUG LABEL 1 0228-2027 TABLET 0.25 mg ORAL ANDA 29 sections
Alprazolam HUMAN PRESCRIPTION DRUG LABEL 1 0228-2027 TABLET 0.25 mg ORAL ANDA 29 sections
Alprazolam HUMAN PRESCRIPTION DRUG LABEL 1 0228-2027 TABLET 0.25 mg ORAL ANDA 29 sections
Alprazolam HUMAN PRESCRIPTION DRUG LABEL 1 0228-2029 TABLET 0.50 mg ORAL ANDA 29 sections
Alprazolam HUMAN PRESCRIPTION DRUG LABEL 1 0228-2029 TABLET 0.50 mg ORAL ANDA 29 sections
Alprazolam HUMAN PRESCRIPTION DRUG LABEL 1 0228-2029 TABLET 0.50 mg ORAL ANDA 29 sections
Alprazolam HUMAN PRESCRIPTION DRUG LABEL 1 0228-2031 TABLET 1 mg ORAL ANDA 29 sections
Alprazolam HUMAN PRESCRIPTION DRUG LABEL 1 0228-2031 TABLET 1 mg ORAL ANDA 29 sections