alprazolam ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
diazepam derivatives 136 28981-97-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • xanax
  • alprazolam
  • alprozolam
  • alzolam
A triazolobenzodiazepine compound with antianxiety and sedative-hypnotic actions, that is efficacious in the treatment of PANIC DISORDERS, with or without AGORAPHOBIA, and in generalized ANXIETY DISORDERS. (From AMA Drug Evaluations Annual, 1994, p238)
  • Molecular weight: 308.77
  • Formula: C17H13ClN4
  • CLOGP: 2.56
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 0
  • TPSA: 43.07
  • ALOGS: -3.98
  • ROTB: 1

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
1 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.07 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 20 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.46 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 88 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.80 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 0.74 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.29 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 12 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Oct. 16, 1981 FDA PHARMACIA AND UPJOHN

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug abuse 5353.45 9.74 3303 218035 56543 50327243
Completed suicide 3822.37 9.74 3725 217613 128164 50255622
Sopor 1862.63 9.74 1132 220206 18747 50365039
Toxicity to various agents 1645.35 9.74 3158 218180 209341 50174445
Respiratory arrest 1279.06 9.74 1056 220282 28953 50354833
Poisoning 1090.69 9.74 679 220659 11750 50372036
Suicide attempt 949.50 9.74 1151 220187 50581 50333205
Cardio-respiratory arrest 866.09 9.74 1122 220216 52770 50331016
Intentional overdose 815.02 9.74 1176 220162 61328 50322458
Cardiac arrest 766.22 9.74 1339 219999 82312 50301474
Drug dependence 638.02 9.74 594 220744 19165 50364621
Coma 590.34 9.74 963 220375 55916 50327870
Poisoning deliberate 584.68 9.74 388 220950 7524 50376262
Overdose 566.33 9.74 1308 220030 98419 50285367
Pemphigus 507.71 9.74 3 221335 120163 50263623
Contraindicated product administered 484.42 9.74 46 221292 148912 50234874
Synovitis 449.89 9.74 22 221316 123843 50259943
Somnolence 414.02 9.74 1553 219785 153432 50230354
Intentional self-injury 403.96 9.74 502 220836 22610 50361176
Drug intolerance 391.38 9.74 237 221101 218867 50164919
Intentional product misuse 385.30 9.74 715 220623 46019 50337767
Treatment failure 382.02 9.74 70 221268 137567 50246219
Hand deformity 379.93 9.74 13 221325 100186 50283600
Systemic lupus erythematosus 370.49 9.74 81 221257 140541 50243245
Joint swelling 355.03 9.74 330 221008 244956 50138830
Infusion related reaction 354.28 9.74 149 221189 169408 50214378
Rheumatoid arthritis 329.52 9.74 243 221095 202307 50181479
Drug ineffective 329.12 9.74 2171 219167 817162 49566624
Glossodynia 303.52 9.74 67 221271 115502 50268284
Arthropathy 298.77 9.74 159 221179 157747 50226039
Anti-cyclic citrullinated peptide antibody positive 287.56 9.74 4 221334 70583 50313203
Off label use 283.57 9.74 1093 220245 473333 49910453
Anxiety 282.45 9.74 1526 219812 176080 50207706
Maternal exposure during pregnancy 273.93 9.74 181 221157 159597 50224189
Pericarditis 267.50 9.74 20 221318 78669 50305117
Lower respiratory tract infection 258.61 9.74 51 221287 95150 50288636
Depression 250.01 9.74 1402 219936 164021 50219765
Bradyphrenia 244.37 9.74 208 221130 5944 50377842
Alopecia 232.14 9.74 450 220888 244597 50139189
Suicidal ideation 230.24 9.74 646 220692 54739 50329047
Drug withdrawal syndrome 226.08 9.74 399 220939 24682 50359104
Swelling 222.22 9.74 334 221004 200538 50183248
Substance abuse 187.93 9.74 151 221187 3973 50379813
Mydriasis 182.74 9.74 229 221109 10398 50373388
Exposure via ingestion 182.20 9.74 127 221211 2676 50381110
Panic attack 179.90 9.74 312 221026 19030 50364756
Discomfort 177.42 9.74 129 221209 108251 50275535
Wound 177.02 9.74 123 221215 105671 50278115
Therapeutic product effect decreased 176.25 9.74 201 221137 135849 50247937
Withdrawal syndrome 174.51 9.74 292 221046 17298 50366488
Death 173.69 9.74 2179 219159 323200 50060586
Product use issue 173.65 9.74 240 221098 149235 50234551
Hypersensitivity 168.67 9.74 438 220900 214723 50169063
Abdominal discomfort 168.56 9.74 489 220849 231152 50152634
Helicobacter infection 167.87 9.74 13 221325 49689 50334097
Nasopharyngitis 165.19 9.74 375 220963 192552 50191234
Infection 155.63 9.74 327 221011 172627 50211159
Hepatic enzyme increased 152.25 9.74 228 221110 137152 50246634
Arthralgia 152.04 9.74 1210 220128 437492 49946294
Agitation 148.98 9.74 543 220795 52841 50330945
Peripheral swelling 142.42 9.74 445 220893 205491 50178295
Rash 140.53 9.74 1231 220107 436240 49947546
Loss of consciousness 139.08 9.74 856 220482 103497 50280289
Prescription form tampering 136.75 9.74 61 221277 507 50383279
Folliculitis 130.40 9.74 11 221327 39214 50344572
Drug use disorder 126.40 9.74 106 221232 2966 50380820
Tremor 126.16 9.74 898 220440 114005 50269781
Sleep disorder due to general medical condition, insomnia type 119.43 9.74 4 221334 31443 50352343
Victim of chemical submission 113.86 9.74 43 221295 220 50383566
Muscle injury 109.29 9.74 16 221322 37095 50346691
Insomnia 106.67 9.74 1202 220136 173663 50210123
Therapeutic product effect incomplete 100.27 9.74 153 221185 91362 50292424
C-reactive protein abnormal 94.68 9.74 7 221331 27802 50355984
Disturbance in attention 91.06 9.74 322 221016 30864 50352922
Impaired healing 88.28 9.74 105 221233 69681 50314105
Bradykinesia 86.07 9.74 96 221242 3847 50379939
Hepatocellular injury 85.52 9.74 279 221059 25668 50358118
Musculoskeletal stiffness 85 9.74 283 221055 128198 50255588
General physical health deterioration 82.85 9.74 331 221007 142103 50241683
Fall 81.18 9.74 1977 219361 332955 50050831
Drug hypersensitivity 80.51 9.74 706 220632 250304 50133482
Accidental overdose 80.31 9.74 227 221111 19306 50364480
C-reactive protein increased 79.91 9.74 104 221234 66370 50317416
Nervousness 79.44 9.74 284 221054 27367 50356419
Gastrointestinal disorder 78.02 9.74 187 221151 94269 50289517
Drug screen positive 78.02 9.74 85 221253 3317 50380469
Crying 77.90 9.74 231 221107 20185 50363601
Pyrexia 77.27 9.74 1184 220154 379019 50004767
Alcohol abuse 76.99 9.74 65 221273 1836 50381950
Memory impairment 76.73 9.74 602 220736 78758 50305028
Feeling abnormal 76.64 9.74 863 220475 124629 50259157
Sinusitis 72.86 9.74 442 220896 170116 50213670
Irritable bowel syndrome 72.16 9.74 71 221267 51370 50332416
Miosis 71.10 9.74 111 221227 6199 50377587
Macular degeneration 71.08 9.74 179 221159 14209 50369577
Drug abuser 70.75 9.74 74 221264 2754 50381032
Altered state of consciousness 69.00 9.74 232 221106 21678 50362108
Febrile neutropenia 68.17 9.74 210 221128 97457 50286329
Depressed level of consciousness 67.79 9.74 424 220914 51529 50332257
Confusional state 67.65 9.74 1166 220172 184762 50199024
Suspected suicide 65.67 9.74 98 221240 5259 50378527
Disorientation 65.37 9.74 318 221020 35166 50348620
Stomatitis 65.13 9.74 226 221112 101118 50282668
Hypokinesia 64.60 9.74 156 221182 12061 50371725
Blister 63.72 9.74 178 221160 85240 50298546
Knee arthroplasty 63.55 9.74 39 221299 35807 50347979
Cough 61.42 9.74 717 220621 240547 50143239
Rheumatic fever 61.18 9.74 3 221335 16864 50366922
Abnormal behaviour 60.88 9.74 207 221131 19451 50364335
Ill-defined disorder 58.30 9.74 93 221245 54561 50329225
Dependence 57.88 9.74 55 221283 1820 50381966
Pain 57.64 9.74 2014 219324 576889 49806897
Amnesia 57.09 9.74 348 220990 41912 50341874
Pneumonia 56.56 9.74 1243 220095 377158 50006628
Exposure during pregnancy 55.73 9.74 306 221032 120709 50263077
Hip arthroplasty 55.51 9.74 32 221306 30397 50353389
Drug resistance 54.07 9.74 9 221329 18980 50364806
Irritability 53.99 9.74 257 221081 28169 50355617
Product use in unapproved indication 52.71 9.74 294 221044 115525 50268261
Vertigo 52.21 9.74 397 220941 51435 50332351
Urinary retention 50.62 9.74 238 221100 25952 50357834
Homicide 50.47 9.74 27 221311 345 50383441
Aggression 50.05 9.74 204 221134 20912 50362874
Euphoric mood 46.62 9.74 72 221266 3983 50379803
Hallucination, auditory 46.39 9.74 127 221211 10601 50373185
Psychomotor skills impaired 46.34 9.74 51 221287 2013 50381773
Condition aggravated 46.03 9.74 970 220368 296088 50087698
Abnormal dreams 45.63 9.74 116 221222 9261 50374525
Anhedonia 45.50 9.74 117 221221 9407 50374379
Hyponatraemia 45.30 9.74 630 220708 95509 50288277
Wrong patient received product 45.27 9.74 46 221292 1654 50382132
Malignant neoplasm progression 44.38 9.74 151 221187 67973 50315813
Myelosuppression 44.36 9.74 4 221334 13513 50370273
Rheumatoid nodule 43.94 9.74 3 221335 12732 50371054
Thinking abnormal 43.12 9.74 115 221223 9452 50374334
Renal impairment 42.60 9.74 178 221160 75483 50308303
Neutropenic sepsis 41.88 9.74 6 221332 14141 50369645
Mania 41.15 9.74 123 221215 10793 50372993
Neutropenia 41.08 9.74 431 220907 147534 50236252
Mobility decreased 40.85 9.74 195 221143 79753 50304033
Mental disorder 40.44 9.74 197 221141 21794 50361992
Delirium 40.42 9.74 296 221042 37896 50345890
Respiratory depression 40.34 9.74 130 221208 11880 50371906
Bradypnoea 40.24 9.74 58 221280 3016 50380770
Psychomotor hyperactivity 40.11 9.74 110 221228 9191 50374595
Anger 39.28 9.74 124 221214 11209 50372577
Hallucinations, mixed 39.21 9.74 67 221271 4036 50379750
Live birth 38.31 9.74 12 221326 16396 50367390
Alcohol poisoning 37.88 9.74 43 221295 1757 50382029
Sepsis 37.79 9.74 385 220953 132540 50251246
Mucosal inflammation 37.66 9.74 74 221264 40068 50343718
Hyperhidrosis 37.38 9.74 574 220764 88852 50294934
Nightmare 37.01 9.74 154 221184 15932 50367854
Product complaint 36.62 9.74 122 221216 11344 50372442
Premature delivery 36.36 9.74 30 221308 23633 50360153
Drug interaction 36.01 9.74 1135 220203 198486 50185300
Cytomegalovirus infection 35.55 9.74 17 221321 17945 50365841
Red blood cell sedimentation rate increased 35.36 9.74 46 221292 29370 50354416
Substance use disorder 35.24 9.74 14 221324 84 50383702
Chemical submission 35.14 9.74 17 221321 173 50383613
Blood pressure diastolic decreased 34.59 9.74 15 221323 16766 50367020
Compartment syndrome 34.53 9.74 43 221295 1939 50381847
Bone erosion 34.50 9.74 5 221333 11682 50372104
Emotional distress 34.36 9.74 229 221109 28434 50355352
Neutrophil count decreased 34.25 9.74 96 221242 45930 50337856
Intentional product use issue 34.04 9.74 197 221141 76721 50307065
Serotonin syndrome 33.68 9.74 204 221134 24509 50359277
Head injury 33.20 9.74 199 221139 23821 50359965
Dysphoria 33.17 9.74 68 221270 4706 50379080
Hallucination 32.71 9.74 330 221008 46327 50337459
Therapy non-responder 32.62 9.74 114 221224 50908 50332878
Housebound 32.35 9.74 17 221321 209 50383577
Renal papillary necrosis 32 9.74 17 221321 214 50383572
Dysarthria 31.97 9.74 276 221062 37127 50346659
Road traffic accident 31.92 9.74 199 221139 24153 50359633
Impaired driving ability 31.86 9.74 60 221278 3901 50379885
Pancytopenia 31.68 9.74 226 221112 83804 50299982
Cholecystitis chronic 30.99 9.74 103 221235 9566 50374220
Immobilisation prolonged 30.92 9.74 13 221325 92 50383694
Arthritis 30.89 9.74 237 221101 86484 50297302
Persistent genital arousal disorder 30.61 9.74 17 221321 235 50383551
Adverse drug reaction 30.41 9.74 131 221207 55091 50328695
Adjustment disorder with mixed anxiety and depressed mood 29.93 9.74 12 221326 74 50383712
Obsessive-compulsive disorder 29.91 9.74 53 221285 3287 50380499
Skin ulcer 29.88 9.74 69 221269 35249 50348537
Speech disorder 29.70 9.74 261 221077 35287 50348499
Medication error 29.61 9.74 264 221074 35840 50347946
Sedation 29.45 9.74 232 221106 30378 50353408
Drug detoxification 29.42 9.74 14 221324 137 50383649
Hallucination, visual 29.39 9.74 147 221191 16435 50367351
Accidental death 29.06 9.74 37 221301 1707 50382079
Fear 28.69 9.74 133 221205 14416 50369370
Sluggishness 28.50 9.74 61 221277 4352 50379434
Multiple injuries 28.46 9.74 36 221302 1650 50382136
Electrocardiogram QT prolonged 28.18 9.74 349 220989 51537 50332249
Psoriatic arthropathy 28.14 9.74 108 221230 46924 50336862
Blood pressure systolic increased 27.84 9.74 72 221266 35377 50348409
Psychomotor retardation 27.77 9.74 52 221286 3366 50380420
Dyspnoea 27.38 9.74 2044 219294 545564 49838222
Femur fracture 27.24 9.74 79 221259 37385 50346401
Fatigue 27.12 9.74 2697 218641 704904 49678882
Suspected counterfeit product 26.95 9.74 17 221321 301 50383485
Drug tolerance decreased 26.85 9.74 4 221334 9156 50374630
Panic disorder 26.63 9.74 41 221297 2262 50381524
Pruritus 26.61 9.74 993 220345 282575 50101211
Bipolar I disorder 26.56 9.74 33 221305 1485 50382301
Wheezing 26.35 9.74 161 221177 61886 50321900
Device expulsion 26.29 9.74 54 221284 28768 50355018
Suicidal behaviour 26.22 9.74 41 221297 2293 50381493
Extrapyramidal disorder 25.77 9.74 111 221227 11659 50372127
Bradycardia 25.58 9.74 410 220928 64016 50319770
COVID-19 25.51 9.74 111 221227 46551 50337235
Blood pressure diastolic abnormal 25.43 9.74 5 221333 9356 50374430
Hypotension 25.12 9.74 1265 220073 234204 50149582
Inflammation 25.05 9.74 146 221192 56766 50327020
Feeling of despair 24.86 9.74 37 221301 1981 50381805
Poverty of speech 24.34 9.74 16 221322 305 50383481
Post-traumatic stress disorder 23.89 9.74 56 221282 4247 50379539
Respiratory acidosis 23.75 9.74 69 221269 5959 50377827
Hyponatraemic encephalopathy 23.65 9.74 14 221324 220 50383566
Anaphylactic reaction 23.62 9.74 139 221199 53916 50329870
Cholestasis 23.61 9.74 191 221147 25210 50358576
Injury 23.59 9.74 322 221016 48603 50335183
Stress 23.52 9.74 348 220990 53445 50330341
Injection site erythema 23.42 9.74 212 221126 74724 50309062
Hypersomnia 23.20 9.74 130 221208 15184 50368602
Muscle spasms 23.18 9.74 716 220622 124837 50258949
Bronchiectasis 23.17 9.74 8 221330 10275 50373511
Urticaria 22.77 9.74 414 220924 129147 50254639
Obstructive airways disorder 22.65 9.74 21 221317 15631 50368155
Bipolar disorder 22.57 9.74 73 221265 6684 50377102
Pregnancy 22.52 9.74 61 221277 29516 50354270
Transplant rejection 22.48 9.74 7 221331 9602 50374184
Blood creatinine increased 22.29 9.74 219 221119 75941 50307845
Blood pressure fluctuation 22.25 9.74 81 221257 35742 50348044
Anticholinergic syndrome 22.24 9.74 33 221305 1762 50382024
Seizure 22.23 9.74 674 220664 117200 50266586
Benzodiazepine drug level abnormal 22.18 9.74 5 221333 0 50383786
Inadequate analgesia 22.15 9.74 40 221298 2518 50381268
Foot deformity 22.12 9.74 31 221307 19179 50364607
Apathy 22.08 9.74 78 221260 7470 50376316
Necrosis ischaemic 21.97 9.74 22 221316 777 50383009
Tonic clonic movements 21.81 9.74 27 221311 1210 50382576
Herpes zoster 21.80 9.74 201 221137 70585 50313201
Grip strength decreased 21.75 9.74 13 221325 12108 50371678
Liver function test increased 21.68 9.74 50 221288 25556 50358230
Drug withdrawal syndrome neonatal 21.60 9.74 33 221305 1808 50381978
Affect lability 21.38 9.74 87 221251 8911 50374875
Hallucination, gustatory 21.37 9.74 9 221329 64 50383722
Cardiac failure 21.28 9.74 221 221117 75819 50307967
Multiple sclerosis 21.21 9.74 158 221180 20335 50363451
Acquired amegakaryocytic thrombocytopenia 21.16 9.74 6 221332 9 50383777
Leukopenia 21.12 9.74 191 221147 67337 50316449
Restlessness 21.12 9.74 185 221153 24988 50358798
Pneumocystis jirovecii pneumonia 20.83 9.74 20 221318 14643 50369143
Self-injurious ideation 20.78 9.74 36 221302 2193 50381593
Asthenia 20.74 9.74 1642 219696 317400 50066386
Toxicologic test abnormal 20.62 9.74 19 221319 604 50383182
Rhabdomyolysis 20.54 9.74 261 221077 38766 50345020
Cellulitis 20.54 9.74 204 221134 70594 50313192
Multiple sclerosis relapse 20.40 9.74 282 221056 42682 50341104
Hepatic function abnormal 20.23 9.74 74 221264 32607 50351179
Injection site swelling 20.12 9.74 104 221234 41669 50342117
Somnambulism 20.02 9.74 57 221281 4867 50378919
Electrocardiogram QRS complex prolonged 19.94 9.74 60 221278 5284 50378502
Face injury 19.93 9.74 40 221298 2726 50381060
Neurotoxicity 19.92 9.74 21 221317 14719 50369067
Drug withdrawal convulsions 19.90 9.74 27 221311 1326 50382460
Metastases to liver 19.79 9.74 36 221302 20068 50363718
Mood altered 19.73 9.74 109 221229 12664 50371122
Logorrhoea 19.69 9.74 36 221302 2288 50381498
Alcohol use 19.63 9.74 33 221305 1962 50381824
Platelet count decreased 19.59 9.74 316 221022 100410 50283376
Wrong patient 19.56 9.74 9 221329 81 50383705
Asthma 19.53 9.74 274 221064 89063 50294723
Basal cell carcinoma 19.46 9.74 46 221292 23310 50360476
Panic reaction 19.33 9.74 46 221292 3523 50380263
Drug eruption 19.27 9.74 47 221291 23559 50360227
Parkinsonism 19.04 9.74 83 221255 8764 50375022
Abortion spontaneous 19.01 9.74 106 221232 41666 50342120
Tarsal tunnel syndrome 18.94 9.74 17 221321 522 50383264
Gun shot wound 18.92 9.74 9 221329 88 50383698
Body temperature increased 18.73 9.74 72 221266 31269 50352517
Thermal burn 18.68 9.74 55 221283 4786 50379000
Hypochloraemia 18.59 9.74 29 221309 1618 50382168
Feeling jittery 18.43 9.74 97 221241 11063 50372723
Mental status changes 18.43 9.74 241 221097 36031 50347755
Cutaneous T-cell dyscrasia 18.41 9.74 8 221330 62 50383724
Blood lactic acid 18.40 9.74 9 221329 94 50383692
Blood bilirubin increased 18.26 9.74 75 221263 31963 50351823
Inappropriate antidiuretic hormone secretion 18.23 9.74 109 221229 13034 50370752
Depressed mood 18.11 9.74 228 221110 33795 50349991
Cyanosis 18.01 9.74 121 221217 15063 50368723
Initial insomnia 17.76 9.74 56 221282 5059 50378727
Partner stress 17.67 9.74 13 221325 299 50383487
Tension 17.63 9.74 38 221300 2724 50381062
Substance dependence 17.52 9.74 11 221327 193 50383593
Major depression 17.51 9.74 68 221270 6816 50376970
Ulcer 17.46 9.74 39 221299 20161 50363625
Vision blurred 17.41 9.74 459 220879 78188 50305598
Graft versus host disease 17.38 9.74 3 221335 6163 50377623
Aplastic anaemia 17.34 9.74 6 221332 7697 50376089
Dermatitis allergic 17.33 9.74 18 221320 12702 50371084
Lupus-like syndrome 17.28 9.74 10 221328 9481 50374305
Disease progression 17.26 9.74 305 221033 95561 50288225
Chronic obstructive pulmonary disease 17.24 9.74 329 221009 53106 50330680
Incoherent 17.23 9.74 49 221289 4181 50379605
Diarrhoea 17.17 9.74 2284 219054 586192 49797594
Cardiogenic shock 17.14 9.74 122 221216 15477 50368309
Stupor 17.10 9.74 44 221294 3539 50380247
Drug screen negative 17.00 9.74 12 221326 258 50383528
Generalised tonic-clonic seizure 16.98 9.74 183 221155 26127 50357659
Torsade de pointes 16.96 9.74 99 221239 11736 50372050
Purging 16.96 9.74 7 221331 47 50383739
Productive cough 16.94 9.74 148 221190 52546 50331240
Morbid thoughts 16.92 9.74 16 221322 526 50383260
Therapeutic response decreased 16.85 9.74 129 221209 47102 50336684
Sarcomatoid carcinoma 16.69 9.74 6 221332 26 50383760
Product substitution issue 16.66 9.74 112 221226 13945 50369841
Mental disability 16.66 9.74 8 221330 80 50383706
Burn oesophageal 16.63 9.74 10 221328 162 50383624
Formication 16.61 9.74 44 221294 3602 50380184
Death of relative 16.58 9.74 11 221327 213 50383573
Neuroleptic malignant syndrome 16.54 9.74 94 221244 11036 50372750
Drug-induced liver injury 16.50 9.74 65 221273 28030 50355756
Septic shock 16.48 9.74 165 221173 57010 50326776
Body temperature decreased 16.46 9.74 29 221309 16366 50367420
Disinhibition 16.45 9.74 19 221319 791 50382995
Tubulointerstitial nephritis and uveitis syndrome 16.41 9.74 10 221328 166 50383620
Blood pressure diastolic increased 16.41 9.74 6 221332 7437 50376349
Substance use 16.34 9.74 13 221325 337 50383449
Developmental delay 16.33 9.74 24 221314 1270 50382516
Tumour lysis syndrome 16.33 9.74 6 221332 7415 50376371
Alcoholism 16.21 9.74 27 221311 1593 50382193
Dysuria 16.03 9.74 193 221145 28311 50355475
Hyperreflexia 15.94 9.74 54 221284 5064 50378722
Electrocardiogram QRS complex shortened 15.87 9.74 14 221324 420 50383366
Haemophagocytic lymphohistiocytosis 15.86 9.74 9 221329 8624 50375162
Ataxia 15.84 9.74 109 221229 13677 50370109
Anaemia 15.83 9.74 923 220415 251533 50132253
Pain in extremity 15.81 9.74 1005 220333 271860 50111926
Blood pressure systolic abnormal 15.70 9.74 7 221331 7699 50376087
Osteonecrosis of jaw 15.65 9.74 81 221257 32445 50351341
Alkalosis hypochloraemic 15.62 9.74 9 221329 134 50383652
Cardiac valve disease 15.56 9.74 44 221294 3742 50380044
Delusion 15.53 9.74 89 221249 10480 50373306
Cardio-respiratory arrest neonatal 15.52 9.74 4 221334 3 50383783
Tendonitis 15.49 9.74 31 221307 16674 50367112
Liver injury 15.47 9.74 56 221282 24750 50359036
Diffuse large B-cell lymphoma 15.43 9.74 3 221335 5659 50378127
Bundle branch block right 15.35 9.74 50 221288 4595 50379191
Skin necrosis 15.23 9.74 15 221323 10852 50372934
Slow speech 15.07 9.74 23 221315 1259 50382527
Multiple organ dysfunction syndrome 15.04 9.74 144 221194 50193 50333593
Nodular rash 15.01 9.74 10 221328 195 50383591
Unresponsive to stimuli 14.98 9.74 202 221136 30407 50353379
Gambling disorder 14.86 9.74 22 221316 1172 50382614
Obsessive-compulsive personality disorder 14.85 9.74 5 221333 17 50383769
Dysgeusia 14.82 9.74 246 221092 38670 50345116
Pneumonia streptococcal 14.76 9.74 26 221312 1605 50382181
Theft 14.75 9.74 7 221331 68 50383718
Migraine 14.61 9.74 432 220906 74848 50308938
Coma scale 14.57 9.74 6 221332 40 50383746
Apraxia 14.46 9.74 25 221313 1520 50382266
Therapeutic response unexpected 14.43 9.74 119 221219 15796 50367990
Tenosynovitis 14.34 9.74 15 221323 10550 50373236
Faecal vomiting 14.26 9.74 15 221323 562 50383224
Neonatal behavioural syndrome 14.21 9.74 6 221332 43 50383743
Waxy flexibility 14.19 9.74 8 221330 114 50383672
Brain death 14.14 9.74 35 221303 2748 50381038
Haemoglobin decreased 14.12 9.74 436 220902 126780 50257006
Vascular headache 14.09 9.74 6 221332 44 50383742
Uveitis 14.06 9.74 12 221326 9298 50374488
Panniculitis 14.06 9.74 10 221328 8493 50375293
Obsessive thoughts 13.97 9.74 14 221324 495 50383291
Acute myeloid leukaemia 13.96 9.74 28 221310 15046 50368740
Emotional disorder 13.85 9.74 94 221244 11742 50372044
Metastases to bone 13.78 9.74 37 221301 17958 50365828
Prothrombin level decreased 13.76 9.74 14 221324 504 50383282
Normal newborn 13.76 9.74 6 221332 6685 50377101
Osteoarthritis 13.75 9.74 214 221124 68392 50315394
Ascites 13.73 9.74 96 221242 35765 50348021
Localised infection 13.70 9.74 61 221277 25424 50358362
Blood parathyroid hormone decreased 13.67 9.74 7 221331 7107 50376679
Oesophageal food impaction 13.62 9.74 9 221329 173 50383613
Adverse event 13.59 9.74 124 221214 43639 50340147
Alanine aminotransferase increased 13.50 9.74 289 221049 88070 50295716
Diabetic ketoacidosis 13.50 9.74 37 221301 17835 50365951
Pleural effusion 13.46 9.74 263 221075 81191 50302595
Injection site pain 13.45 9.74 376 220962 110648 50273138
Wrong rate 13.44 9.74 6 221332 50 50383736
Pre-existing condition improved 13.35 9.74 64 221274 7033 50376753
LDL/HDL ratio increased 13.31 9.74 3 221335 0 50383786
Maternal exposure before pregnancy 13.24 9.74 4 221334 5593 50378193
Tardive dyskinesia 13.23 9.74 65 221273 7214 50376572
Oropharyngeal pain 13.22 9.74 250 221088 77551 50306235
Soliloquy 13.19 9.74 9 221329 183 50383603
Full blood count abnormal 13.17 9.74 55 221283 23333 50360453
Dizziness 13.13 9.74 1718 219620 344651 50039135
Joint effusion 13.10 9.74 23 221315 12998 50370788
Cerebral microangiopathy 13.09 9.74 10 221328 244 50383542
Exposure via inhalation 13.02 9.74 5 221333 27 50383759
Gallbladder disorder 13.00 9.74 121 221217 16621 50367165
Product physical issue 12.87 9.74 45 221293 4287 50379499
Atrioventricular septal defect 12.84 9.74 10 221328 251 50383535
Brugada syndrome 12.78 9.74 11 221327 319 50383467
Laryngomalacia 12.76 9.74 6 221332 57 50383729
Premature labour 12.74 9.74 19 221319 11457 50372329
Homicidal ideation 12.73 9.74 25 221313 1677 50382109
Phobia 12.73 9.74 11 221327 321 50383465
Suspiciousness 12.73 9.74 11 221327 321 50383465
Distributive shock 12.72 9.74 17 221321 823 50382963
Congenital central nervous system anomaly 12.70 9.74 11 221327 322 50383464
Conversion disorder 12.62 9.74 24 221314 1572 50382214
Oesophageal achalasia 12.53 9.74 12 221326 401 50383385
Hyporesponsive to stimuli 12.52 9.74 18 221320 934 50382852
Gastrointestinal haemorrhage 12.34 9.74 236 221102 73085 50310701
Pneumoconiosis 12.25 9.74 4 221334 12 50383774
Cutaneous lymphoma 12.24 9.74 8 221330 151 50383635
Libido decreased 12.20 9.74 30 221308 2346 50381440
Cardio-respiratory distress 12.19 9.74 8 221330 152 50383634
Persecutory delusion 12.11 9.74 30 221308 2357 50381429
Performance status decreased 12.04 9.74 36 221302 3159 50380627
Divorced 12.02 9.74 4 221334 13 50383773
Victim of crime 12.00 9.74 6 221332 66 50383720
Deep vein thrombosis 11.96 9.74 412 220926 72892 50310894
Gallbladder hypofunction 11.83 9.74 13 221325 512 50383274
Sleep disorder due to a general medical condition 11.76 9.74 9 221329 7362 50376424
Cognitive disorder 11.72 9.74 264 221074 43859 50339927
Craniosynostosis 11.71 9.74 8 221330 163 50383623
Bone density decreased 11.66 9.74 19 221319 11056 50372730
Coagulation factor V level decreased 11.62 9.74 10 221328 290 50383496
Musculoskeletal disorder 11.60 9.74 38 221300 17311 50366475
Poor venous access 11.59 9.74 17 221321 10323 50373463
Prescription drug used without a prescription 11.56 9.74 24 221314 1676 50382110
Throat irritation 11.55 9.74 81 221257 30158 50353628
Drug screen false positive 11.53 9.74 16 221322 803 50382983
Prothrombin level increased 11.46 9.74 9 221329 229 50383557
Hyperaldosteronism 11.46 9.74 9 221329 229 50383557
Toxic epidermal necrolysis 11.43 9.74 50 221288 20942 50362844
Paranoia 11.41 9.74 81 221257 10267 50373519
Crime 11.38 9.74 4 221334 16 50383770
Hepatotoxicity 11.37 9.74 71 221267 27155 50356631
Product quality issue 11.36 9.74 194 221144 30664 50353122
Hypercalcaemia 11.32 9.74 58 221280 23294 50360492
Eating disorder 11.29 9.74 110 221228 15299 50368487
Pharyngitis 11.26 9.74 39 221299 17464 50366322
Limb fracture 11.24 9.74 3 221335 3 50383783
Pelvic floor dysfunction 11.24 9.74 3 221335 3 50383783
Enthesopathy 11.20 9.74 9 221329 7184 50376602
Blastocystis infection 11.19 9.74 4 221334 17 50383769
Tubulointerstitial nephritis 11.11 9.74 32 221306 15179 50368607
Injection site reaction 11.09 9.74 153 221185 49879 50333907
Balance disorder 11.08 9.74 395 220943 70195 50313591
Creatinine renal clearance decreased 11.06 9.74 22 221316 11859 50371927
Counterfeit product administered 11.01 9.74 4 221334 18 50383768
Hypotonia 10.99 9.74 67 221271 8067 50375719
Hair texture abnormal 10.88 9.74 38 221300 3618 50380168
Clostridium difficile infection 10.80 9.74 66 221272 25373 50358413
Liver function test abnormal 10.78 9.74 133 221205 44206 50339580
Retrograde amnesia 10.72 9.74 11 221327 400 50383386
Depersonalisation/derealisation disorder 10.72 9.74 19 221319 1179 50382607
Joint stiffness 10.71 9.74 83 221255 30225 50353561
Corneal reflex decreased 10.67 9.74 7 221331 133 50383653
Perseveration 10.67 9.74 9 221329 254 50383532
Akathisia 10.63 9.74 67 221271 8162 50375624
Haemorrhage 10.60 9.74 167 221171 53274 50330512
Dyskinesia 10.57 9.74 176 221162 27685 50356101
Blood alcohol increased 10.57 9.74 13 221325 579 50383207
Oligohydramnios 10.55 9.74 6 221332 5744 50378042
Blood creatine phosphokinase increased 10.54 9.74 168 221170 26199 50357587
Blood cholesterol increased 10.47 9.74 174 221164 55041 50328745
Pancreatitis acute 10.39 9.74 154 221184 23658 50360128
Beta haemolytic streptococcal infection 10.36 9.74 24 221314 1806 50381980
Encephalopathy 10.34 9.74 206 221132 33505 50350281
Haematochezia 10.32 9.74 118 221220 39764 50344022
Rhinorrhoea 10.30 9.74 161 221177 51422 50332364
Abdominal operation 10.29 9.74 12 221326 505 50383281
Injection site pruritus 10.29 9.74 120 221218 40291 50343495
Reduced facial expression 10.25 9.74 22 221316 1572 50382214
Nephropathy toxic 10.23 9.74 12 221326 8017 50375769
Injection site bruising 10.23 9.74 107 221231 36661 50347125
Newborn persistent pulmonary hypertension 10.23 9.74 7 221331 143 50383643
Venoocclusive liver disease 10.16 9.74 3 221335 4258 50379528
Arthritis bacterial 10.15 9.74 6 221332 5623 50378163
Postmortem blood drug level abnormal 10.11 9.74 10 221328 348 50383438
Electroencephalogram abnormal 10.10 9.74 36 221302 3463 50380323
Erythrodermic psoriasis 10.10 9.74 16 221322 905 50382881
Purpura senile 10.07 9.74 12 221326 517 50383269
Hyperinsulinism 10.04 9.74 3 221335 6 50383780
Cardioplegia 10.04 9.74 3 221335 6 50383780
Pneumonia aspiration 10.03 9.74 191 221147 30813 50352973
Nephrosclerosis 10.01 9.74 16 221322 912 50382874
Sensitivity to weather change 10.00 9.74 7 221331 5994 50377792
Tuberculosis 9.97 9.74 18 221320 10065 50373721
Lethargy 9.95 9.74 285 221053 49147 50334639
Polyarthritis 9.94 9.74 12 221326 7915 50375871
Gait disturbance 9.88 9.74 773 220565 149232 50234554
Feeling of relaxation 9.84 9.74 5 221333 57 50383729
Polydipsia 9.76 9.74 33 221305 3091 50380695
Attention deficit hyperactivity disorder 9.76 9.74 28 221310 2401 50381385

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug abuse 7256.17 10.54 4129 101626 75754 29393018
Completed suicide 2069.61 10.54 2046 103709 88200 29380572
Toxicity to various agents 2015.05 10.54 2770 102985 170891 29297881
Respiratory arrest 1809.71 10.54 1135 104620 24698 29444074
Poisoning 1432.25 10.54 704 105051 9289 29459483
Cardio-respiratory arrest 1048.63 10.54 1088 104667 49513 29419259
Cardiac arrest 870.68 10.54 1286 104469 84305 29384467
Intentional product misuse 736.85 10.54 756 104999 33905 29434867
Drug dependence 674.26 10.54 576 105179 20405 29448367
Sopor 655.28 10.54 436 105319 10498 29458274
Overdose 526.58 10.54 988 104767 78831 29389941
Coma 522.54 10.54 674 105081 38776 29429996
Suicide attempt 509.59 10.54 619 105136 33491 29435281
Intentional overdose 440.91 10.54 613 105142 37915 29430857
Poisoning deliberate 349.26 10.54 231 105524 5500 29463272
Exposure via ingestion 270.64 10.54 136 105619 1882 29466890
Prescription form tampering 229.90 10.54 79 105676 373 29468399
Withdrawal syndrome 224.72 10.54 235 105520 10757 29458015
Drug withdrawal syndrome 208.33 10.54 288 105467 17696 29451076
Drug use disorder 189.51 10.54 130 105625 3292 29465480
Somnolence 186.66 10.54 747 105008 93208 29375564
Accidental overdose 186.43 10.54 270 105485 17323 29451449
Substance abuse 177.54 10.54 166 105589 6621 29462151
Intentional self-injury 176.00 10.54 220 105535 12241 29456531
Off label use 158.04 10.54 550 105205 300250 29168522
Miosis 147.44 10.54 162 105593 7847 29460925
Drug abuser 145.66 10.54 116 105639 3711 29465061
Anxiety 138.85 10.54 639 105116 84726 29384046
Death 136.68 10.54 1841 103914 340243 29128529
Febrile neutropenia 127.43 10.54 128 105627 112112 29356660
Respiratory depression 125.37 10.54 195 105560 13328 29455444
Bradypnoea 124.08 10.54 87 105668 2284 29466488
Pyrexia 122.48 10.54 571 105184 287051 29181721
Suicidal ideation 116.98 10.54 330 105425 34386 29434386
Agitation 101.01 10.54 407 105348 50897 29417875
Drug screen positive 99.47 10.54 93 105662 3708 29465064
Depression 97.96 10.54 579 105176 84568 29384204
Drug ineffective 96.80 10.54 833 104922 362337 29106435
Pneumonia 84.50 10.54 736 105019 319436 29149336
Bradyphrenia 82.39 10.54 88 105667 4126 29464646
Insomnia 80.84 10.54 569 105186 88192 29380580
Depressed level of consciousness 72.63 10.54 293 105462 36649 29432123
Sepsis 71.90 10.54 265 105490 142417 29326355
Accidental death 71.77 10.54 60 105695 2058 29466714
Neutropenia 69.43 10.54 240 105515 131471 29337301
Counterfeit product administered 67.96 10.54 25 105730 149 29468623
Product use in unapproved indication 64.98 10.54 133 105622 86742 29382030
Treatment failure 63.88 10.54 26 105729 36913 29431859
Panic attack 63.56 10.54 110 105645 8216 29460556
Renal impairment 62.99 10.54 122 105633 81211 29387561
Unresponsive to stimuli 61.64 10.54 214 105541 24912 29443860
Cough 60.83 10.54 240 105515 126487 29342285
Infection 59.54 10.54 115 105640 76636 29392136
Asphyxia 58.38 10.54 83 105672 5232 29463540
C-reactive protein increased 56.74 10.54 45 105710 44218 29424554
Aggression 56.18 10.54 264 105491 35277 29433495
Drug resistance 55.73 10.54 6 105749 21534 29447238
Drug tolerance 55.04 10.54 52 105703 2101 29466671
Cytomegalovirus infection 54.04 10.54 9 105746 23206 29445566
Irritability 53.76 10.54 188 105567 21964 29446808
Infusion related reaction 53.32 10.54 47 105708 43839 29424933
Amnesia 52.24 10.54 189 105566 22454 29446318
Toxicologic test abnormal 51.86 10.54 29 105726 504 29468268
Pulmonary oedema 51.29 10.54 294 105461 42441 29426331
Product counterfeit 50.46 10.54 19 105736 122 29468650
Lower respiratory tract infection 50.34 10.54 16 105739 26486 29442286
Platelet count decreased 49.72 10.54 199 105556 104473 29364299
Anaemia 49.34 10.54 470 105285 200481 29268291
Postmortem blood drug level abnormal 48.95 10.54 23 105732 272 29468500
Diarrhoea 48.86 10.54 867 104888 331831 29136941
Alcohol interaction 46.87 10.54 53 105702 2650 29466122
Abnormal behaviour 45.10 10.54 183 105572 22944 29445828
Rash 44.47 10.54 449 105306 189370 29279402
Hepatic function abnormal 44.23 10.54 45 105710 39214 29429558
Self-medication 43.92 10.54 46 105709 2108 29466664
Narcotic bowel syndrome 39.82 10.54 16 105739 125 29468647
Acute kidney injury 39.29 10.54 690 105065 264577 29204195
Tremor 39.27 10.54 419 105336 73119 29395653
Mucosal inflammation 38.18 10.54 34 105721 31561 29437211
Disorientation 37.36 10.54 206 105549 29309 29439463
Abulia 37.08 10.54 23 105732 488 29468284
Pulmonary congestion 36.87 10.54 113 105642 12323 29456449
Cardiac failure 36.85 10.54 152 105603 79135 29389637
Pancytopenia 36.47 10.54 163 105592 83005 29385767
Blood creatinine increased 36.00 10.54 169 105586 84933 29383839
Neutrophil count decreased 34.89 10.54 64 105691 43503 29425269
Interstitial lung disease 34.72 10.54 99 105656 57619 29411153
Loss of consciousness 34.58 10.54 411 105344 73645 29395127
COVID-19 34.44 10.54 47 105708 35967 29432805
Anger 34.22 10.54 101 105654 10789 29457983
Dyspnoea 34.10 10.54 899 104856 325833 29142939
Respiratory rate decreased 33.49 10.54 38 105717 1907 29466865
Condition aggravated 33.02 10.54 349 105406 145946 29322826
Joint swelling 32.98 10.54 81 105674 49549 29419223
Paramnesia 32.64 10.54 8 105747 6 29468766
Brain oedema 32.54 10.54 107 105648 12113 29456659
White blood cell count decreased 32.14 10.54 171 105584 83191 29385581
Arthralgia 31.94 10.54 332 105423 139285 29329487
Road traffic accident 31.83 10.54 125 105630 15436 29453336
Haemoglobin decreased 31.22 10.54 243 105512 108132 29360640
Nervousness 31.01 10.54 100 105655 11206 29457566
Altered state of consciousness 30.88 10.54 147 105608 19742 29449030
Suspected suicide 30.54 10.54 53 105702 3967 29464805
Feeling abnormal 30.37 10.54 313 105442 54132 29414640
Dependence 30.36 10.54 27 105728 1008 29467764
Pneumocystis jirovecii pneumonia 30.35 10.54 11 105744 16768 29452004
Bone marrow failure 30.31 10.54 32 105723 27417 29441355
Respiratory failure 30.26 10.54 213 105542 96918 29371854
Alcohol abuse 30.18 10.54 55 105700 4278 29464494
Myelosuppression 30.16 10.54 4 105751 12223 29456549
Drug withdrawal syndrome neonatal 30.13 10.54 48 105707 3347 29465425
Disturbance in attention 29.47 10.54 153 105602 21271 29447501
Analgesic drug level increased 29.30 10.54 21 105734 571 29468201
Drug detoxification 29.18 10.54 14 105741 174 29468598
Gastrointestinal haemorrhage 29.09 10.54 166 105589 79367 29389405
Drug intolerance 29.08 10.54 83 105672 48296 29420476
Disease progression 28.89 10.54 173 105582 81743 29387029
Homicide 28.81 10.54 25 105730 903 29467869
Alcohol use 28.79 10.54 45 105710 3087 29465685
Therapeutic product effect incomplete 28.66 10.54 61 105694 39244 29429528
Bladder dilatation 28.59 10.54 29 105726 1279 29467493
Neutropenic sepsis 28.54 10.54 4 105751 11723 29457049
General physical health deterioration 28.52 10.54 233 105522 102624 29366148
Renal failure 27.95 10.54 280 105475 118319 29350453
Rheumatoid arthritis 27.78 10.54 45 105710 32107 29436665
Psychomotor hyperactivity 27.57 10.54 78 105677 8135 29460637
Angioedema 27.27 10.54 45 105710 31870 29436902
Cerebral haemorrhage 27.14 10.54 44 105711 31382 29437390
Bradykinesia 26.91 10.54 46 105709 3401 29465371
Hyperthermia 26.40 10.54 84 105671 9346 29459426
Distributive shock 25.58 10.54 24 105731 961 29467811
Lactic acidosis 25.52 10.54 43 105712 30204 29438568
Erythema 25.45 10.54 162 105593 75444 29393328
Panic disorder 25.32 10.54 26 105729 1164 29467608
Thinking abnormal 25.19 10.54 57 105698 5179 29463593
Hospitalisation 24.73 10.54 83 105672 45905 29422867
Blood pressure fluctuation 24.53 10.54 21 105734 19873 29448899
Malignant neoplasm progression 24.48 10.54 159 105596 73700 29395072
Contraindicated product administered 24.13 10.54 18 105737 18248 29450524
Withdrawal catatonia 24.06 10.54 10 105745 86 29468686
Alanine aminotransferase increased 23.88 10.54 152 105603 70792 29397980
Exposure during pregnancy 23.77 10.54 76 105679 8478 29460294
Gun shot wound 23.62 10.54 24 105731 1061 29467711
Hypervigilance 23.56 10.54 11 105744 128 29468644
Hypervolaemia 23.55 10.54 17 105738 17528 29451244
Stomatitis 23.55 10.54 62 105693 37051 29431721
Incorrect route of product administration 23.10 10.54 88 105667 10713 29458059
Generalised anxiety disorder 22.97 10.54 19 105736 642 29468130
Dysarthria 22.95 10.54 189 105566 30722 29438050
Inadequate analgesia 22.84 10.54 37 105718 2617 29466155
Pneumonia aspiration 22.81 10.54 216 105539 36521 29432251
Nasopharyngitis 22.65 10.54 123 105632 59542 29409230
Mydriasis 22.63 10.54 60 105695 6025 29462747
Cardiac failure congestive 22.37 10.54 171 105584 76410 29392362
Deafness neurosensory 22.27 10.54 36 105719 2542 29466230
Atrial fibrillation 22.23 10.54 256 105499 105390 29363382
Accident 22.21 10.54 44 105711 3644 29465128
Drug tolerance increased 21.95 10.54 16 105739 447 29468325
Chorea 21.90 10.54 22 105733 959 29467813
Acute myocardial infarction 21.79 10.54 94 105661 48344 29420428
Hyperleukocytosis 21.71 10.54 28 105727 1607 29467165
Substance use disorder 21.42 10.54 13 105742 265 29468507
Sedation 21.04 10.54 120 105635 17285 29451487
Poverty of speech 20.89 10.54 12 105743 220 29468552
Stevens-Johnson syndrome 20.85 10.54 17 105738 16480 29452292
Bronchopulmonary aspergillosis 20.84 10.54 9 105746 12335 29456437
Aspergillus infection 20.79 10.54 6 105749 10575 29458197
Vestibular ischaemia 20.65 10.54 6 105749 14 29468758
Ascites 20.44 10.54 65 105690 36554 29432218
Oedematous pancreatitis 20.13 10.54 15 105740 434 29468338
Anaphylactic reaction 19.93 10.54 43 105712 27530 29441242
Major depression 19.86 10.54 43 105712 3792 29464980
Hypersensitivity 19.56 10.54 110 105645 52793 29415979
Drug diversion 19.54 10.54 19 105736 796 29467976
Puncture site haematoma 19.42 10.54 10 105745 146 29468626
Pleural effusion 19.42 10.54 164 105591 71744 29397028
Hyperkalaemia 19.42 10.54 134 105621 61258 29407514
Serotonin syndrome 19.40 10.54 118 105637 17394 29451378
Pathogen resistance 19.22 10.54 3 105752 8113 29460659
Pruritus 19.18 10.54 298 105457 116551 29352221
Dizziness 19.17 10.54 524 105231 189160 29279612
Haematochezia 19.04 10.54 68 105687 36915 29431857
Urticaria 18.96 10.54 116 105639 54544 29414228
Myocardial infarction 18.89 10.54 279 105476 110017 29358755
Myotonia 18.85 10.54 7 105748 43 29468729
Psoriatic arthropathy 18.74 10.54 15 105740 14676 29454096
Heart rate decreased 18.72 10.54 38 105717 24874 29443898
Catatonia 18.63 10.54 46 105709 4422 29464350
Cytokine release syndrome 18.56 10.54 12 105743 13107 29455665
Papillary muscle disorder 18.55 10.54 4 105751 0 29468772
Neurotoxicity 18.54 10.54 15 105740 14598 29454174
Leukopenia 18.20 10.54 119 105636 55084 29413688
Substance abuser 18.20 10.54 8 105747 80 29468692
Sudden death 18.20 10.54 99 105656 14011 29454761
Haemorrhage 18.18 10.54 91 105664 44981 29423791
Legal problem 18.08 10.54 10 105745 170 29468602
Confusional state 17.97 10.54 591 105164 127286 29341486
Liver disorder 17.88 10.54 46 105709 27703 29441069
Cerebral congestion 17.87 10.54 6 105749 26 29468746
Liver function test abnormal 17.83 10.54 49 105706 28869 29439903
Inappropriate schedule of product administration 17.82 10.54 90 105665 44382 29424390
Herpes zoster 17.73 10.54 52 105703 30000 29438772
Slow speech 17.68 10.54 19 105736 897 29467875
Pneumonitis 17.68 10.54 47 105708 27997 29440775
Hepatotoxicity 17.40 10.54 23 105732 17844 29450928
Tachyphylaxis 17.38 10.54 8 105747 90 29468682
Thrombocytopenia 17.33 10.54 359 105396 134464 29334308
Memory impairment 17.27 10.54 203 105552 36267 29432505
Drug withdrawal convulsions 17.20 10.54 21 105734 1140 29467632
Obstructive airways disorder 17.11 10.54 9 105746 11007 29457765
Leukoencephalopathy 17.01 10.54 40 105715 3727 29465045
Gastric haemorrhage 16.98 10.54 6 105749 9291 29459481
Blood triglycerides decreased 16.66 10.54 7 105748 62 29468710
Lymphadenopathy 16.54 10.54 41 105714 25008 29443764
Bacterial prostatitis 16.47 10.54 7 105748 64 29468708
Diabetic ketoacidosis 16.37 10.54 20 105735 16053 29452719
Foetal exposure during pregnancy 16.30 10.54 64 105691 33803 29434969
Product substitution 16.28 10.54 6 105749 36 29468736
Asthma 16.27 10.54 64 105691 33785 29434987
Anamnestic reaction 16.14 10.54 6 105749 37 29468735
Cataract 16.09 10.54 35 105720 22343 29446429
Oedema peripheral 16.03 10.54 267 105488 103290 29365482
Blood creatine phosphokinase 16.01 10.54 7 105748 69 29468703
Delirium 15.96 10.54 213 105542 39184 29429588
Bacteraemia 15.91 10.54 21 105734 16302 29452470
Cerebral infarction 15.82 10.54 41 105714 24634 29444138
Epistaxis 15.79 10.54 114 105641 51590 29417182
Ventricular tachyarrhythmia 15.74 10.54 11 105744 287 29468485
Victim of crime 15.70 10.54 12 105743 361 29468411
Brachial plexus injury 15.59 10.54 7 105748 74 29468698
Sexual dysfunction 15.56 10.54 51 105704 5763 29463009
Renal tubular necrosis 15.46 10.54 17 105738 14298 29454474
Acute myeloid leukaemia 15.33 10.54 22 105733 16491 29452281
Wheezing 15.26 10.54 64 105691 33176 29435596
Peripheral swelling 15.20 10.54 150 105605 63589 29405183
Transplant rejection 15.10 10.54 7 105748 9205 29459567
Blood pressure systolic increased 15.10 10.54 23 105732 16822 29451950
Homicidal ideation 15.06 10.54 30 105725 2494 29466278
Nephropathy toxic 15.00 10.54 10 105745 10746 29458026
Speech disorder 14.96 10.54 139 105616 23377 29445395
Tubulointerstitial nephritis 14.95 10.54 25 105730 17618 29451154
Melaena 14.95 10.54 59 105696 31117 29437655
Cyclothymic disorder 14.88 10.54 7 105748 83 29468689
Drug eruption 14.87 10.54 23 105732 16718 29452054
Intrusive thoughts 14.86 10.54 10 105745 245 29468527
Cardio-respiratory distress 14.73 10.54 8 105747 131 29468641
Hallucination, visual 14.67 10.54 98 105657 14917 29453855
Anticholinergic syndrome 14.61 10.54 17 105738 877 29467895
Thymus disorder 14.53 10.54 4 105751 7 29468765
COVID-19 pneumonia 14.47 10.54 8 105747 9514 29459258
Acute hepatic failure 14.27 10.54 13 105742 11939 29456833
Amimia 14.18 10.54 4 105751 8 29468764
Mania 14.16 10.54 65 105690 8598 29460174
Prothrombin time shortened 14.14 10.54 21 105734 1377 29467395
Liver function test increased 14.10 10.54 13 105742 11872 29456900
Dissociative disorder 13.99 10.54 9 105746 204 29468568
Psychomotor skills impaired 13.97 10.54 30 105725 2631 29466141
Sepsis pasteurella 13.91 10.54 3 105752 0 29468772
Blood lactate dehydrogenase increased 13.84 10.54 30 105725 19179 29449593
Prostate cancer 13.77 10.54 46 105709 25481 29443291
Hyporesponsive to stimuli 13.76 10.54 17 105738 934 29467838
Myositis 13.75 10.54 10 105745 10273 29458499
Osteoporosis 13.73 10.54 11 105744 10758 29458014
Drug screen negative 13.72 10.54 8 105747 151 29468621
Exposure via inhalation 13.71 10.54 5 105750 29 29468743
Arthropathy 13.68 10.54 36 105719 21518 29447254
Panic reaction 13.66 10.54 20 105735 1295 29467477
Inflammation 13.65 10.54 39 105716 22689 29446083
Scleroderma renal crisis 13.55 10.54 7 105748 103 29468669
Cholangitis 13.53 10.54 5 105750 7532 29461240
Physical assault 13.52 10.54 18 105737 1066 29467706
Oedema 13.48 10.54 87 105668 40396 29428376
Osteonecrosis of jaw 13.44 10.54 24 105731 16486 29452286
Tumour lysis syndrome 13.39 10.54 18 105737 13866 29454906
Femoral artery aneurysm 13.23 10.54 8 105747 162 29468610
Hyperhidrosis 13.19 10.54 313 105442 64227 29404545
Impatience 13.13 10.54 10 105745 299 29468473
Therapeutic response decreased 13.01 10.54 45 105710 24666 29444106
Squamous cell carcinoma of skin 12.98 10.54 9 105746 9477 29459295
Full blood count abnormal 12.98 10.54 21 105734 14992 29453780
Adrenergic syndrome 12.92 10.54 6 105749 69 29468703
Incision site pain 12.89 10.54 23 105732 1760 29467012
Central nervous system necrosis 12.86 10.54 7 105748 115 29468657
Second primary malignancy 12.82 10.54 4 105751 6701 29462071
Bipolar disorder 12.77 10.54 33 105722 3262 29465510
Hypocalcaemia 12.75 10.54 35 105720 20630 29448142
Judgement impaired 12.71 10.54 13 105742 579 29468193
Feeling jittery 12.68 10.54 35 105720 3598 29465174
Haemoconcentration 12.68 10.54 5 105750 37 29468735
Euphoric mood 12.62 10.54 42 105713 4783 29463989
Victim of homicide 12.60 10.54 7 105748 120 29468652
Peripheral nerve paresis 12.56 10.54 5 105750 38 29468734
Troponin T increased 12.53 10.54 20 105735 1397 29467375
Low birth weight baby 12.53 10.54 4 105751 6604 29462168
Theft 12.49 10.54 9 105746 247 29468525
Aspartate aminotransferase increased 12.44 10.54 145 105610 59580 29409192
Prescription drug used without a prescription 12.36 10.54 19 105736 1285 29467487
Medication error 12.32 10.54 123 105632 21088 29447684
Progressive multifocal leukoencephalopathy 12.30 10.54 8 105747 8711 29460061
Paradoxical drug reaction 12.26 10.54 29 105726 2712 29466060
Septic shock 12.23 10.54 154 105601 62406 29406366
Mobility decreased 12.23 10.54 49 105706 25731 29443041
Chloasma 12.17 10.54 4 105751 16 29468756
Cellulitis 12.17 10.54 105 105650 45735 29423037
Upper gastrointestinal haemorrhage 12.16 10.54 39 105716 21875 29446897
Therapy non-responder 12.13 10.54 63 105692 30848 29437924
Blood alcohol increased 12.13 10.54 14 105741 716 29468056
Hallucination 12.12 10.54 226 105529 44486 29424286
Amnestic disorder 12.11 10.54 8 105747 190 29468582
Electrocardiogram QT prolonged 12.10 10.54 189 105566 35948 29432824
Conversion disorder 12.06 10.54 10 105745 339 29468433
Lip swelling 12.06 10.54 16 105739 12394 29456378
Pulseless electrical activity 12.01 10.54 4 105751 6430 29462342
Nervous system disorder 11.95 10.54 82 105673 12592 29456180
Clostridium difficile colitis 11.88 10.54 18 105737 13194 29455578
Oropharyngeal pain 11.88 10.54 59 105696 29226 29439546
Product use issue 11.87 10.54 122 105633 51322 29417450
Benign mesenteric neoplasm 11.84 10.54 3 105752 3 29468769
Shoplifting 11.84 10.54 3 105752 3 29468769
Personality change 11.80 10.54 40 105715 4598 29464174
Colitis microscopic 11.80 10.54 22 105733 1741 29467031
Conjunctivitis 11.75 10.54 7 105748 7991 29460781
Substance-induced mood disorder 11.75 10.54 6 105749 86 29468686
Basal cell carcinoma 11.70 10.54 27 105728 16883 29451889
Acute stress disorder 11.65 10.54 7 105748 140 29468632
Hypoventilation 11.58 10.54 29 105726 2812 29465960
Hepatic enzyme increased 11.58 10.54 72 105683 33727 29435045
Sluggishness 11.51 10.54 30 105725 2981 29465791
Hypothermia 11.36 10.54 64 105691 9175 29459597
Haematuria 11.32 10.54 102 105653 44037 29424735
Circulatory collapse 11.24 10.54 32 105723 18641 29450131
Sleep disorder 11.22 10.54 135 105620 24251 29444521
Body temperature decreased 11.15 10.54 13 105742 10651 29458121
Cardiorenal syndrome 11.13 10.54 13 105742 673 29468099
Urinary tract infection 11.04 10.54 187 105568 72167 29396605
Erythema multiforme 11.00 10.54 7 105748 7710 29461062
Extrapyramidal disorder 10.77 10.54 71 105684 10760 29458012
Sputum discoloured 10.74 10.54 5 105750 6558 29462214
Respiratory acidosis 10.73 10.54 37 105718 4291 29464481
Malaise 10.72 10.54 464 105291 159138 29309634
Osteonecrosis 10.70 10.54 20 105735 13499 29455273
Pulmonary fibrosis 10.69 10.54 25 105730 15557 29453215
Ear infection 10.67 10.54 8 105747 8092 29460680
Injection site pain 10.66 10.54 70 105685 32376 29436396
Visceral congestion 10.63 10.54 11 105744 497 29468275
Apathy 10.61 10.54 47 105708 6124 29462648
Atrial flutter 10.60 10.54 21 105734 13873 29454899
Paranoia 10.59 10.54 66 105689 9811 29458961

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug abuse 11923.73 9.89 7147 256474 125227 64109884
Completed suicide 6041.10 9.89 5897 257724 218517 64016594
Toxicity to various agents 3562.92 9.89 5758 257863 357755 63877356
Respiratory arrest 3342.65 9.89 2293 261328 50692 64184419
Poisoning 2442.39 9.89 1363 262258 20516 64214595
Sopor 2441.08 9.89 1517 262104 28144 64206967
Cardio-respiratory arrest 1998.33 9.89 2230 261391 96163 64138948
Cardiac arrest 1811.65 9.89 2661 260960 151403 64083708
Suicide attempt 1324.96 9.89 1541 262080 69466 64165645
Intentional overdose 1236.04 9.89 1675 261946 88269 64146842
Intentional product misuse 1111.72 9.89 1423 262198 70872 64164239
Coma 1096.58 9.89 1560 262061 86055 64149056
Overdose 1088.02 9.89 2164 261457 157402 64077709
Drug dependence 1060.30 9.89 964 262657 32348 64202763
Poisoning deliberate 939.85 9.89 621 263000 12837 64222274
Intentional self-injury 593.25 9.89 661 262960 28383 64206728
Somnolence 551.70 9.89 1958 261663 201687 64033424
Death 503.61 9.89 3534 260087 479171 63755940
Exposure via ingestion 431.71 9.89 262 263359 4640 64230471
Drug ineffective 399.89 9.89 1924 261697 838323 63396788
Off label use 366.88 9.89 1342 262279 631464 63603647
Drug withdrawal syndrome 353.12 9.89 531 263090 30760 64204351
Synovitis 337.59 9.89 16 263605 99074 64136037
Substance abuse 331.54 9.89 287 263334 9005 64226106
Drug use disorder 298.72 9.89 226 263395 5828 64229283
Bradyphrenia 296.78 9.89 271 263350 9135 64225976
Withdrawal syndrome 294.55 9.89 419 263202 23073 64212038
Infusion related reaction 288.85 9.89 156 263465 164311 64070800
Drug abuser 286.99 9.89 217 263404 5591 64229520
Treatment failure 285.17 9.89 64 263557 116752 64118359
Drug intolerance 273.80 9.89 220 263401 187772 64047339
Anxiety 265.89 9.89 1574 262047 201075 64034036
Contraindicated product administered 263.36 9.89 59 263562 107770 64127341
Joint swelling 256.93 9.89 301 263320 215081 64020030
Lower respiratory tract infection 236.70 9.89 49 263572 94565 64140546
Suicidal ideation 235.03 9.89 701 262920 65841 64169270
Pemphigus 227.70 9.89 4 263617 60697 64174414
Accidental overdose 224.39 9.89 452 263169 33105 64202006
Depression 216.02 9.89 1385 262236 181906 64053205
Rheumatoid arthritis 212.04 9.89 215 263406 164079 64071032
Hand deformity 207.92 9.89 12 263609 62759 64172352
Mydriasis 197.71 9.89 277 263344 15035 64220076
Pyrexia 193.64 9.89 1413 262208 557231 63677880
Miosis 192.54 9.89 254 263367 13012 64222099
Agitation 192.19 9.89 793 262828 87574 64147537
Febrile neutropenia 186.74 9.89 299 263322 187358 64047753
Anti-cyclic citrullinated peptide antibody positive 182.95 9.89 4 263617 49558 64185553
Arthropathy 174.26 9.89 143 263478 120824 64114287
Pericarditis 165.71 9.89 28 263593 62488 64172623
Nasopharyngitis 163.50 9.89 348 263273 195725 64039386
Infection 161.91 9.89 319 263302 184561 64050550
Systemic lupus erythematosus 160.80 9.89 58 263563 77554 64157557
Prescription form tampering 158.07 9.89 59 263562 315 64234796
Respiratory depression 149.89 9.89 310 263311 23133 64211978
Maternal exposure during pregnancy 146.15 9.89 107 263514 95777 64139334
Bradypnoea 144.25 9.89 139 263482 5020 64230091
Pneumonia 143.93 9.89 1528 262093 558048 63677063
Arthralgia 140.64 9.89 1145 262476 441115 63793996
Panic attack 138.60 9.89 281 263340 20672 64214439
Drug screen positive 132.01 9.89 139 263482 5590 64229521
Depressed level of consciousness 128.31 9.89 665 262956 80771 64154340
Loss of consciousness 127.77 9.89 1040 262581 147325 64087786
Rash 126.95 9.89 1230 262391 457319 63777792
Hypersensitivity 125.22 9.89 399 263222 196053 64039058
Therapeutic product effect decreased 124.19 9.89 174 263447 115177 64119934
Duodenal ulcer perforation 123.29 9.89 4 263617 34621 64200490
Hepatic enzyme increased 121.87 9.89 215 263406 129728 64105383
C-reactive protein increased 121.49 9.89 125 263496 94784 64140327
Tremor 116.48 9.89 1018 262603 147212 64087899
Glossodynia 115.51 9.89 60 263561 64636 64170475
Sepsis 114.92 9.89 517 263104 229824 64005287
Victim of chemical submission 114.76 9.89 44 263577 256 64234855
Cough 112.37 9.89 748 262873 301400 63933711
General physical health deterioration 109.22 9.89 447 263174 203978 64031133
Insomnia 107.88 9.89 1260 262361 196576 64038535
Swelling 107.36 9.89 318 263303 159900 64075211
Product use in unapproved indication 106.84 9.89 367 263254 176251 64058860
Peripheral swelling 102.79 9.89 472 263149 208681 64026430
Helicobacter infection 102.06 9.89 17 263604 38345 64196766
Bradykinesia 102.06 9.89 130 263491 6430 64228681
Drug resistance 101.73 9.89 12 263609 35090 64200021
Renal impairment 99.38 9.89 256 263365 134761 64100350
Neutropenia 99.02 9.89 574 263047 239050 63996061
Altered state of consciousness 97.72 9.89 359 263262 37543 64197568
Disturbance in attention 97.58 9.89 379 263242 40695 64194416
Alcohol abuse 96.59 9.89 109 263512 4743 64230368
Cytomegalovirus infection 93.56 9.89 19 263602 37180 64197931
Therapeutic product effect incomplete 92.76 9.89 176 263445 103306 64131805
Accidental death 92.35 9.89 94 263527 3631 64231480
Product use issue 91.25 9.89 316 263305 151399 64083712
Wound 87.78 9.89 110 263511 76367 64158744
Folliculitis 85.40 9.89 11 263610 30066 64205045
Sleep disorder due to general medical condition, insomnia type 84.08 9.89 6 263615 26264 64208847
Alopecia 83.73 9.89 370 263251 165320 64069791
Discomfort 81.20 9.89 128 263493 80750 64154361
Mucosal inflammation 77.20 9.89 85 263536 62499 64172612
Amnesia 76.58 9.89 395 263226 47874 64187237
Hepatocellular injury 76.57 9.89 377 263244 44858 64190253
Disorientation 76.53 9.89 439 263182 55389 64179722
Neutropenic sepsis 75.41 9.89 5 263616 23267 64211844
Platelet count decreased 75.13 9.89 391 263230 167320 64067791
Aggression 73.81 9.89 379 263242 45853 64189258
Stomatitis 72.35 9.89 219 263402 109386 64125725
Dyspnoea 72.14 9.89 2314 261307 716360 63518751
Anaemia 70.79 9.89 1105 262516 377575 63857536
Sinusitis 70.66 9.89 331 263290 145597 64089514
Pancytopenia 70.61 9.89 323 263298 142986 64092125
Suspected suicide 69.46 9.89 126 263495 8528 64226583
Myelosuppression 69.42 9.89 8 263613 23822 64211289
Abnormal behaviour 69.36 9.89 297 263324 33325 64201786
Neutrophil count decreased 66.83 9.89 134 263487 77062 64158049
Condition aggravated 65.86 9.89 1098 262523 371328 63863783
Confusional state 65.63 9.89 1462 262159 259682 63975429
Abdominal discomfort 64.41 9.89 458 263163 181864 64053247
Homicide 63.59 9.89 46 263575 1105 64234006
Hypokinesia 63.52 9.89 180 263441 16416 64218695
Toxicologic test abnormal 63.26 9.89 47 263574 1178 64233933
Gastrointestinal disorder 62.29 9.89 175 263446 89534 64145577
Malignant neoplasm progression 62.01 9.89 244 263377 112627 64122484
Hepatic function abnormal 61.55 9.89 105 263516 64208 64170903
Nervousness 60.91 9.89 261 263360 29295 64205816
Diarrhoea 60.16 9.89 2381 261240 720323 63514788
Dependence 60.13 9.89 58 263563 2097 64233014
Irritability 59.89 9.89 303 263318 36443 64198668
Memory impairment 58.45 9.89 571 263050 85111 64150000
Euphoric mood 58.11 9.89 100 263521 6491 64228620
Psychomotor skills impaired 57.94 9.89 75 263546 3770 64231341
Muscle injury 57.81 9.89 18 263603 26419 64208692
Musculoskeletal stiffness 55.30 9.89 287 263334 122919 64112192
Blood pressure fluctuation 55.06 9.89 79 263542 51792 64183319
Blood creatinine increased 54.57 9.89 328 263293 135454 64099657
Crying 54.07 9.89 193 263428 19897 64215214
Cardiac failure 53.08 9.89 320 263301 132053 64103058
Postmortem blood drug level abnormal 52.94 9.89 33 263588 614 64234497
Substance use disorder 52.54 9.89 27 263594 340 64234771
COVID-19 52.27 9.89 118 263503 65022 64170089
Psychomotor hyperactivity 50.76 9.89 152 263469 14299 64220812
Counterfeit product administered 50.51 9.89 19 263602 104 64235007
Unresponsive to stimuli 50.44 9.89 366 263255 50027 64185084
Impaired healing 49.79 9.89 108 263513 60365 64174746
Acute kidney injury 49.47 9.89 1428 262193 447812 63787299
Drug detoxification 49.29 9.89 23 263598 231 64234880
Fall 48.83 9.89 2126 261495 414700 63820411
Feeling abnormal 48.67 9.89 792 262829 132810 64102301
Alcohol interaction 48.66 9.89 74 263547 4327 64230784
Blister 47.74 9.89 170 263451 80797 64154314
Delirium 47.62 9.89 462 263159 68732 64166379
Pneumocystis jirovecii pneumonia 47.32 9.89 27 263594 27607 64207504
Road traffic accident 46.97 9.89 249 263372 30496 64204615
Haemoglobin decreased 46.61 9.89 541 263080 194522 64040589
Thinking abnormal 45.86 9.89 127 263494 11429 64223682
Blood pressure systolic increased 45.28 9.89 83 263538 49370 64185741
Inflammation 44.88 9.89 128 263493 65172 64169939
Wheezing 44.37 9.89 174 263447 80405 64154706
Herpes zoster 44.24 9.89 170 263451 79017 64156094
Blood pressure diastolic decreased 43.96 9.89 18 263603 22283 64212828
Asthma 43.76 9.89 220 263401 95005 64140106
Anhedonia 43.35 9.89 139 263482 13567 64221544
Vertigo 43.08 9.89 399 263222 58612 64176499
Drug hypersensitivity 43.01 9.89 698 262923 237117 63997994
Medication error 42.82 9.89 350 263271 49616 64185495
Irritable bowel syndrome 42.61 9.89 54 263567 37315 64197796
Sedation 42.57 9.89 303 263318 41159 64193952
Neurotoxicity 42.50 9.89 30 263591 27374 64207737
Product counterfeit 41.93 9.89 20 263601 212 64234899
Transplant rejection 41.51 9.89 10 263611 17391 64217720
Serotonin syndrome 41.46 9.89 289 263332 38993 64196118
Mobility decreased 41.36 9.89 195 263426 85645 64149466
Sluggishness 41.07 9.89 79 263542 5591 64229520
Dysarthria 41.05 9.89 397 263224 59009 64176102
Alcohol use 40.80 9.89 70 263551 4532 64230579
Gastrointestinal haemorrhage 40.79 9.89 345 263276 131967 64103144
Major depression 40.49 9.89 95 263526 7721 64227390
Rheumatoid nodule 40.17 9.89 3 263618 12648 64222463
Ill-defined disorder 39.39 9.89 75 263546 43977 64191134
Obstructive airways disorder 39.21 9.89 23 263598 23162 64211949
Disease progression 39.07 9.89 380 263241 141300 64093811
Red blood cell sedimentation rate increased 38.99 9.89 42 263579 31193 64203918
Pulmonary congestion 38.97 9.89 197 263424 23683 64211428
Anger 38.82 9.89 147 263474 15594 64219517
Poverty of speech 38.68 9.89 26 263595 553 64234558
Mania 38.45 9.89 150 263471 16136 64218975
Hallucination, visual 38.22 9.89 219 263402 27615 64207496
Ascites 38.02 9.89 128 263493 61873 64173238
Self-medication 38.01 9.89 64 263557 4081 64231030
Anaphylactic reaction 37.34 9.89 149 263472 68515 64166596
Electrocardiogram QT prolonged 37.21 9.89 492 263129 78956 64156155
Speech disorder 37.13 9.89 331 263290 48110 64187001
Anticholinergic syndrome 37.03 9.89 50 263571 2619 64232492
Alcohol poisoning 36.78 9.89 64 263557 4191 64230920
Pruritus 36.66 9.89 984 262637 311416 63923695
Skin ulcer 36.64 9.89 78 263543 43896 64191215
Haematochezia 36.11 9.89 144 263477 66229 64168882
Urinary retention 36.08 9.89 333 263288 48868 64186243
Inadequate analgesia 35.92 9.89 61 263560 3917 64231194
Therapy non-responder 35.84 9.89 143 263478 65756 64169355
Panic disorder 35.77 9.89 50 263571 2707 64232404
Drug eruption 35.50 9.89 58 263563 36078 64199033
Cellulitis 35.17 9.89 231 263390 93426 64141685
Emotional distress 34.50 9.89 259 263362 35779 64199332
Body temperature decreased 34.48 9.89 33 263588 25895 64209216
Cerebral haemorrhage 33.76 9.89 102 263519 50988 64184123
Chemical submission 33.30 9.89 17 263604 211 64234900
Asphyxia 33.01 9.89 100 263521 9466 64225645
White blood cell count decreased 32.75 9.89 451 263170 157386 64077725
Alanine aminotransferase increased 32.65 9.89 387 263234 138644 64096467
Blood pressure diastolic abnormal 32.33 9.89 5 263616 11912 64223199
Persistent genital arousal disorder 32.14 9.89 17 263604 228 64234883
Respiratory acidosis 32.13 9.89 101 263520 9754 64225357
Distributive shock 32.12 9.89 39 263582 1836 64233275
Diabetic ketoacidosis 32.12 9.89 45 263576 29800 64205311
Septic shock 32.01 9.89 276 263345 105161 64129950
Urticaria 31.99 9.89 417 263204 146900 64088211
Psoriatic arthropathy 31.87 9.89 82 263539 43199 64191912
Basal cell carcinoma 31.71 9.89 48 263573 30790 64204321
Extrapyramidal disorder 31.70 9.89 161 263460 19391 64215720
Injury 31.52 9.89 359 263262 55633 64179478
Drug withdrawal convulsions 31.27 9.89 41 263580 2087 64233024
Metastases to liver 31.23 9.89 31 263590 23910 64211201
Leukopenia 31.19 9.89 264 263357 100978 64134133
Haemorrhage 31.18 9.89 193 263428 79158 64155953
Exposure during pregnancy 31.00 9.89 188 263433 77487 64157624
Knee arthroplasty 30.80 9.89 39 263582 26960 64208151
Bone marrow failure 30.78 9.89 97 263524 47855 64187256
Abulia 30.73 9.89 27 263594 864 64234247
Pleural effusion 30.60 9.89 350 263271 126209 64108902
Adjustment disorder with mixed anxiety and depressed mood 30.58 9.89 12 263609 75 64235036
Liver function test abnormal 30.37 9.89 132 263489 59269 64175842
Bronchiectasis 30.26 9.89 10 263611 14130 64220981
Intentional product use issue 30.14 9.89 247 263374 95117 64139994
Multiple organ dysfunction syndrome 30.11 9.89 267 263354 101146 64133965
Venoocclusive liver disease 30.10 9.89 3 263618 10012 64225099
Therapeutic response decreased 29.82 9.89 111 263510 52077 64183034
Arthritis 29.35 9.89 211 263410 83603 64151508
Productive cough 29.31 9.89 177 263444 73026 64162085
Bone erosion 29.00 9.89 6 263615 11589 64223522
Acute myeloid leukaemia 28.97 9.89 42 263579 27421 64207690
Osteonecrosis of jaw 28.90 9.89 76 263545 39749 64195362
Narcotic bowel syndrome 28.80 9.89 16 263605 238 64234873
Gun shot wound 28.49 9.89 28 263593 1036 64234075
Interstitial lung disease 28.27 9.89 259 263362 97473 64137638
Respiratory failure 28.16 9.89 476 263145 160707 64074404
Immobilisation prolonged 27.86 9.89 12 263609 98 64235013
Tenosynovitis 27.84 9.89 7 263614 11826 64223285
Aplastic anaemia 27.82 9.89 11 263610 13909 64221202
Pneumonia aspiration 27.73 9.89 367 263254 58904 64176207
Liver disorder 27.62 9.89 118 263503 53233 64181878
Hallucination, auditory 27.12 9.89 139 263482 16800 64218311
Wrong patient 26.99 9.89 14 263607 180 64234931
Tumour lysis syndrome 26.73 9.89 24 263597 19416 64215695
Slow speech 26.52 9.89 37 263584 2000 64233111
Hyperleukocytosis 26.47 9.89 37 263584 2003 64233108
Drug tolerance 26.28 9.89 69 263552 6016 64229095
Toxic epidermal necrolysis 26.16 9.89 72 263549 37094 64198017
Apathy 26.15 9.89 103 263518 11129 64223982
Psychomotor retardation 26.09 9.89 62 263559 5081 64230030
Hallucination 25.93 9.89 430 263191 72358 64162753
Injection site erythema 25.89 9.89 176 263445 70624 64164487
Paramnesia 25.82 9.89 8 263613 21 64235090
Liver function test increased 25.75 9.89 55 263566 30915 64204196
Dysphoria 25.70 9.89 56 263565 4332 64230779
Live birth 25.65 9.89 7 263614 11197 64223914
Tubulointerstitial nephritis 25.61 9.89 55 263566 30854 64204257
Hypervolaemia 25.61 9.89 76 263545 38209 64196902
Thrombocytopenia 25.43 9.89 708 262913 223093 64012018
Fear 25.31 9.89 155 263466 20016 64215095
Aspergillus infection 25.31 9.89 18 263603 16361 64218750
Cyanosis 25.17 9.89 166 263455 21989 64213122
Haemophagocytic lymphohistiocytosis 25.11 9.89 21 263600 17588 64217523
Prescription drug used without a prescription 24.99 9.89 41 263580 2559 64232552
Rheumatic fever 24.99 9.89 4 263617 9290 64225821
Suspected counterfeit product 24.94 9.89 19 263602 495 64234616
Pathogen resistance 24.93 9.89 10 263611 12533 64222578
Heart rate decreased 24.85 9.89 128 263493 54939 64180172
Nephropathy toxic 24.84 9.89 21 263600 17493 64217618
Respiratory rate decreased 24.82 9.89 56 263565 4435 64230676
Cardio-respiratory distress 24.79 9.89 15 263606 264 64234847
Mental disorder 24.72 9.89 189 263432 26256 64208855
Bronchopulmonary aspergillosis 24.56 9.89 25 263596 19060 64216051
Feeling jittery 24.33 9.89 97 263524 10538 64224573
Nightmare 24.28 9.89 158 263463 20835 64214276
Blood lactate dehydrogenase increased 24.10 9.89 63 263558 33015 64202096
Inappropriate schedule of product administration 23.99 9.89 251 263370 92035 64143076
Cholecystitis chronic 23.96 9.89 88 263533 9199 64225912
Multiple injuries 23.94 9.89 46 263575 3253 64231858
Hyporesponsive to stimuli 23.93 9.89 33 263588 1764 64233347
Pain in extremity 23.91 9.89 1004 262617 302081 63933030
Blood bilirubin increased 23.65 9.89 138 263483 57415 64177696
Stevens-Johnson syndrome 23.63 9.89 67 263554 34182 64200929
Injection site pain 23.58 9.89 317 263304 111091 64124020
Impaired driving ability 23.49 9.89 56 263565 4598 64230513
Oropharyngeal pain 23.39 9.89 241 263380 88626 64146485
Hyperhidrosis 23.24 9.89 672 262949 124248 64110863
Exposure via inhalation 23.18 9.89 10 263611 82 64235029
Drug-induced liver injury 23.08 9.89 108 263513 47535 64187576
Full blood count abnormal 22.98 9.89 55 263566 29702 64205409
Fatigue 22.97 9.89 2695 260926 746035 63489076
Myelodysplastic syndrome 22.91 9.89 49 263572 27530 64207581
Hepatotoxicity 22.83 9.89 85 263536 39877 64195234
Pneumonitis 22.76 9.89 117 263504 50248 64184863
Diffuse large B-cell lymphoma 22.75 9.89 7 263614 10354 64224757
Benzodiazepine drug level abnormal 22.52 9.89 5 263616 0 64235111
Angioedema 22.44 9.89 154 263467 61667 64173444
Housebound 22.15 9.89 17 263604 448 64234663
Enthesopathy 22.10 9.89 6 263615 9632 64225479
Lymphadenopathy 21.93 9.89 107 263514 46579 64188532
Homicidal ideation 21.92 9.89 44 263577 3213 64231898
Suicidal behaviour 21.87 9.89 41 263580 2846 64232265
Hallucination, gustatory 21.84 9.89 9 263612 65 64235046
Cerebral infarction 21.72 9.89 90 263531 40954 64194157
Substance abuser 21.38 9.89 10 263611 101 64235010
Bacteraemia 21.38 9.89 49 263572 26862 64208249
Hip arthroplasty 21.22 9.89 34 263587 21317 64213794
Obsessive-compulsive disorder 21.19 9.89 55 263566 4763 64230348
Acquired amegakaryocytic thrombocytopenia 21.18 9.89 6 263615 10 64235101
Renal papillary necrosis 21.15 9.89 15 263606 349 64234762
Hyponatraemic encephalopathy 21.15 9.89 14 263607 290 64234821
Prostate cancer 21.15 9.89 30 263591 19765 64215346
Ankylosing spondylitis 21.14 9.89 4 263617 8230 64226881
Premature delivery 21.05 9.89 27 263594 18562 64216549
Erythema 20.94 9.89 593 263028 186477 64048634
Wrong patient received product 20.89 9.89 47 263574 3715 64231396
Generalised anxiety disorder 20.89 9.89 32 263589 1883 64233228
Femur fracture 20.57 9.89 71 263550 34064 64201047
Withdrawal catatonia 20.51 9.89 11 263610 152 64234959
Obsessive thoughts 20.51 9.89 23 263598 994 64234117
Hypochloraemia 20.49 9.89 33 263588 2028 64233083
Injection site swelling 20.47 9.89 93 263528 41260 64193851
Adrenal insufficiency 20.35 9.89 38 263583 22449 64212662
Blood test abnormal 20.29 9.89 14 263607 12929 64222182
Epstein-Barr virus infection 20.26 9.89 13 263608 12475 64222636
Tension 20.25 9.89 47 263574 3793 64231318
Hypersomnia 20.18 9.89 144 263477 19573 64215538
Mood altered 20.18 9.89 123 263498 15856 64219255
Haematotoxicity 20.15 9.89 14 263607 12882 64222229
Electrocardiogram QRS complex prolonged 20.11 9.89 83 263538 9161 64225950
Upper gastrointestinal haemorrhage 20.06 9.89 75 263546 35145 64199966
Delusion 19.88 9.89 134 263487 17880 64217231
Vestibular ischaemia 19.86 9.89 6 263615 14 64235097
Stupor 19.81 9.89 62 263559 5973 64229138
Drug tolerance increased 19.80 9.89 18 263603 603 64234508
Prothrombin time shortened 19.79 9.89 39 263582 2810 64232301
Hallucinations, mixed 19.71 9.89 62 263559 5990 64229121
Blood pressure systolic abnormal 19.64 9.89 8 263613 9934 64225177
Head injury 19.59 9.89 213 263408 32629 64202482
Inappropriate antidiuretic hormone secretion 19.56 9.89 157 263464 22132 64212979
Hospitalisation 19.36 9.89 205 263416 75002 64160109
Clostridium difficile infection 19.33 9.89 79 263542 36084 64199027
Joint effusion 19.30 9.89 16 263605 13457 64221654
Substance dependence 19.25 9.89 16 263605 474 64234637
Atrial fibrillation 19.23 9.89 542 263079 170547 64064564
Depressed mood 19.20 9.89 254 263367 40758 64194353
Affect lability 18.99 9.89 80 263541 8910 64226201
Purging 18.97 9.89 7 263614 36 64235075
Cutaneous T-cell dyscrasia 18.93 9.89 8 263613 62 64235049
Feeling of despair 18.87 9.89 36 263585 2532 64232579
Acute myocardial infarction 18.79 9.89 188 263433 69530 64165581
Partner stress 18.69 9.89 13 263608 293 64234818
Tonic clonic movements 18.62 9.89 31 263590 1958 64233153
Accident 18.62 9.89 66 263555 6780 64228331
Mouth ulceration 18.54 9.89 69 263552 32375 64202736
Metastases to lung 18.53 9.89 21 263600 15243 64219868
Bipolar I disorder 18.49 9.89 29 263592 1742 64233369
Second primary malignancy 18.49 9.89 14 263607 12323 64222788
Hypocalcaemia 18.31 9.89 98 263523 41655 64193456
Compartment syndrome 18.29 9.89 48 263573 4184 64230927
Analgesic drug level increased 18.15 9.89 33 263588 2237 64232874
Dermatitis allergic 18.11 9.89 21 263600 15088 64220023
Abdominal pain 17.98 9.89 1069 262552 311306 63923805
Grip strength decreased 17.96 9.89 13 263608 11711 64223400
Brachial plexus injury 17.89 9.89 9 263612 108 64235003
Prothrombin level decreased 17.88 9.89 26 263595 1460 64233651
Cholangitis 17.87 9.89 11 263610 10791 64224320
Self-injurious ideation 17.82 9.89 40 263581 3157 64231954
Arthritis bacterial 17.75 9.89 5 263616 7834 64227277
Necrosis ischaemic 17.75 9.89 21 263600 962 64234149
Conversion disorder 17.74 9.89 28 263593 1691 64233420
Blood alcohol increased 17.72 9.89 23 263598 1159 64233952
Blood pressure diastolic increased 17.71 9.89 11 263610 10741 64224370
COVID-19 pneumonia 17.64 9.89 25 263596 16479 64218632
Pain 17.62 9.89 1987 261634 551524 63683587
Feeling of relaxation 17.47 9.89 9 263612 114 64234997
Myocardial infarction 17.46 9.89 530 263091 165291 64069820
Drug interaction 17.42 9.89 1712 261909 360371 63874740
Ulcer 17.36 9.89 43 263578 22947 64212164
Puncture site haematoma 17.31 9.89 10 263611 161 64234950
Multiple-drug resistance 17.03 9.89 3 263618 6499 64228612
Multiple sclerosis 16.94 9.89 134 263487 18807 64216304
Subarachnoid haemorrhage 16.83 9.89 31 263590 18407 64216704
Hyperthermia 16.76 9.89 115 263506 15435 64219676
Foot deformity 16.67 9.89 26 263595 16478 64218633
Body temperature increased 16.67 9.89 85 263536 36581 64198530
Sarcomatoid carcinoma 16.56 9.89 6 263615 29 64235082
Cystitis haemorrhagic 16.38 9.89 6 263615 7950 64227161
Sputum discoloured 16.32 9.89 30 263591 17826 64217285
Poor venous access 16.28 9.89 16 263605 12401 64222710
Anamnestic reaction 16.24 9.89 6 263615 31 64235080
Acute graft versus host disease in skin 16.23 9.89 4 263617 6851 64228260
Therapy partial responder 16.18 9.89 11 263610 10237 64224874
Bladder dilatation 16.17 9.89 28 263593 1826 64233285
Osteonecrosis 16.15 9.89 60 263561 28169 64206942
Somnambulism 16.13 9.89 52 263569 5089 64230022
Tendonitis 16.05 9.89 37 263584 20245 64214866
Rhinorrhoea 16.04 9.89 162 263459 59807 64175304
Influenza 15.98 9.89 323 263298 106208 64128903
Bacterial prostatitis 15.96 9.89 7 263614 60 64235051
Hypervigilance 15.94 9.89 14 263607 448 64234663
Hypersensitivity vasculitis 15.90 9.89 4 263617 6757 64228354
Learning disorder 15.81 9.89 15 263606 531 64234580
Cardiac valve disease 15.81 9.89 52 263569 5143 64229968
Papillary muscle disorder 15.79 9.89 4 263617 3 64235108
LDL/HDL ratio increased 15.79 9.89 4 263617 3 64235108
Pulmonary tuberculosis 15.72 9.89 5 263616 7239 64227872
Graft versus host disease 15.71 9.89 20 263601 13793 64221318
Neuropathy peripheral 15.70 9.89 363 263258 117162 64117949
Device related infection 15.69 9.89 68 263553 30558 64204553
Morbid thoughts 15.64 9.89 17 263604 709 64234402
Jaundice 15.62 9.89 125 263496 48387 64186724
Substance use 15.59 9.89 16 263605 624 64234487
Incoherent 15.55 9.89 64 263557 7054 64228057
Angina pectoris 15.53 9.89 114 263507 44967 64190144
Muscle spasms 15.51 9.89 715 262906 140308 64094803
Hyperreflexia 15.41 9.89 64 263557 7084 64228027
Hypercalcaemia 15.34 9.89 71 263550 31345 64203766
Pulmonary oedema 15.12 9.89 425 263196 78249 64156862
Pregnancy 15.00 9.89 40 263581 20825 64214286
Drug screen negative 14.97 9.89 11 263610 271 64234840
Dyssomnia 14.97 9.89 6 263615 40 64235071
Cytokine release syndrome 14.92 9.89 40 263581 20789 64214322
Fear of injection 14.91 9.89 3 263618 5909 64229202
Drug tolerance decreased 14.88 9.89 5 263616 6993 64228118
Uveitis 14.87 9.89 18 263603 12690 64222421
Tarsal tunnel syndrome 14.87 9.89 14 263607 491 64234620
Victim of crime 14.85 9.89 13 263608 414 64234697
Squamous cell carcinoma of skin 14.79 9.89 16 263605 11860 64223251
Throat irritation 14.78 9.89 76 263545 32635 64202476
BK virus infection 14.58 9.89 6 263615 7406 64227705
Needle issue 14.58 9.89 10 263611 9262 64225849
Epistaxis 14.58 9.89 298 263323 97833 64137278
Logorrhoea 14.54 9.89 43 263578 4016 64231095
Restlessness 14.53 9.89 236 263385 39549 64195562
Alanine aminotransferase abnormal 14.51 9.89 5 263616 6883 64228228
Brain oedema 14.50 9.89 146 263475 21929 64213182
Lip swelling 14.49 9.89 74 263547 31833 64203278
Cerebral congestion 14.48 9.89 6 263615 44 64235067
Gambling disorder 14.47 9.89 27 263594 1867 64233244
Intrusive thoughts 14.45 9.89 12 263609 355 64234756
Blood parathyroid hormone decreased 14.43 9.89 6 263615 7360 64227751
Cataract 14.33 9.89 137 263484 51125 64183986
Blood triglycerides decreased 14.27 9.89 9 263612 171 64234940
Cerebral microangiopathy 14.20 9.89 10 263611 230 64234881
Sleep disorder due to a general medical condition 14.16 9.89 8 263613 8226 64226885
Alcohol withdrawal syndrome 14.15 9.89 26 263595 1777 64233334
Self esteem decreased 13.99 9.89 18 263603 899 64234212
Immunosuppression 13.92 9.89 14 263607 10732 64224379
Hyperkalaemia 13.89 9.89 311 263310 100818 64134293
Drug diversion 13.85 9.89 20 263601 1116 64233995
Gamma-glutamyltransferase increased 13.83 9.89 129 263492 48381 64186730
Electrocardiogram QRS complex shortened 13.79 9.89 15 263606 626 64234485
Blood pressure increased 13.71 9.89 571 263050 171981 64063130
Localised infection 13.67 9.89 70 263551 30091 64205020
Amimia 13.53 9.89 6 263615 53 64235058
Haemorrhage intracranial 13.51 9.89 51 263570 23833 64211278
Colitis 13.51 9.89 164 263457 58510 64176601
Encephalitis 13.48 9.89 19 263602 12552 64222559
Pulmonary alveolar haemorrhage 13.42 9.89 12 263609 9726 64225385
Panniculitis 13.40 9.89 10 263611 8869 64226242
Bipolar disorder 13.39 9.89 59 263562 6702 64228409
Ligament sprain 13.37 9.89 83 263538 10769 64224342
Cognitive disorder 13.36 9.89 307 263314 54780 64180331
Brain death 13.34 9.89 47 263574 4814 64230297
Hyperinsulinism 13.34 9.89 4 263617 9 64235102
Aplasia pure red cell 13.29 9.89 6 263615 7008 64228103
Catatonia 13.24 9.89 64 263557 7556 64227555
Judgement impaired 13.24 9.89 19 263602 1054 64234057
Coma scale 13.24 9.89 6 263615 56 64235055
Lupus-like syndrome 13.14 9.89 10 263611 8781 64226330
Appendicitis 13.12 9.89 22 263599 13547 64221564
Refusal of treatment by patient 13.05 9.89 68 263553 8271 64226840
Blood pressure decreased 13.03 9.89 261 263360 85938 64149173
Palmar-plantar erythrodysaesthesia syndrome 12.99 9.89 67 263554 28752 64206359
Joint stiffness 12.98 9.89 72 263549 30332 64204779
Wrong rate 12.97 9.89 6 263615 59 64235052
Hair texture abnormal 12.91 9.89 34 263587 2970 64232141
Graft versus host disease in skin 12.90 9.89 3 263618 5344 64229767
Oedematous pancreatitis 12.88 9.89 17 263604 871 64234240
Meningioma 12.85 9.89 40 263581 3842 64231269
Cystitis 12.82 9.89 112 263509 42563 64192548
Myocarditis 12.77 9.89 32 263589 17011 64218100
Osteoarthritis 12.76 9.89 182 263439 63154 64171957
Formication 12.72 9.89 43 263578 4314 64230797
Tubulointerstitial nephritis and uveitis syndrome 12.70 9.89 10 263611 274 64234837
Product substitution issue 12.65 9.89 120 263501 17741 64217370
Product complaint 12.64 9.89 88 263533 11866 64223245
Myopathy 12.63 9.89 34 263587 17646 64217465
Abnormal dreams 12.63 9.89 79 263542 10277 64224834
Blood creatine phosphokinase 12.61 9.89 7 263614 104 64235007
Large intestine perforation 12.59 9.89 20 263601 12584 64222527
Aspartate aminotransferase increased 12.58 9.89 383 263238 119405 64115706
Haematemesis 12.55 9.89 127 263494 46872 64188239
Peritonitis 12.55 9.89 56 263565 24967 64210144
Haemolysis 12.53 9.89 16 263605 11023 64224088
Device malfunction 12.53 9.89 34 263587 17599 64217512
Neoplasm progression 12.53 9.89 107 263514 40857 64194254
Mental status changes 12.48 9.89 333 263288 60829 64174282
Pneumatosis intestinalis 12.48 9.89 3 263618 5226 64229885
Pulmonary toxicity 12.47 9.89 10 263611 8551 64226560
Leukoencephalopathy 12.46 9.89 59 263562 6908 64228203
Hyponatraemia 12.43 9.89 733 262888 147606 64087505
Hypothermia 12.41 9.89 130 263491 19726 64215385
Incision site pain 12.40 9.89 31 263590 2623 64232488
Musculoskeletal disorder 12.37 9.89 35 263586 17871 64217240
Therapeutic response shortened 12.33 9.89 14 263607 10156 64224955
Pneumonia bacterial 12.25 9.89 27 263594 15008 64220103
Hypercapnia 12.22 9.89 63 263558 7631 64227480
Cushingoid 12.22 9.89 8 263613 7595 64227516
Urinary tract infection 12.20 9.89 799 262822 230797 64004314
Polyarthritis 12.19 9.89 13 263608 9702 64225409
Proteinuria 12.19 9.89 65 263556 27658 64207453
Cytomegalovirus test positive 12.18 9.89 3 263618 5141 64229970
Substance-induced mood disorder 12.15 9.89 7 263614 112 64234999
Chloasma 12.15 9.89 5 263616 36 64235075
Burning sensation 12.11 9.89 277 263344 49387 64185724
Pulmonary fibrosis 12.08 9.89 72 263549 29806 64205305
Legal problem 12.07 9.89 8 263613 166 64234945
Vestibular disorder 12.02 9.89 28 263593 2265 64232846
Red blood cell count decreased 12.01 9.89 133 263488 48253 64186858
Panic reaction 11.98 9.89 40 263581 3987 64231124
Osteoporosis 11.96 9.89 112 263509 41968 64193143
Cardiac failure congestive 11.93 9.89 425 263196 130155 64104956
International normalised ratio increased 11.88 9.89 240 263381 78927 64156184
Blastocystis infection 11.85 9.89 4 263617 15 64235096
Transfusion 11.83 9.89 36 263585 17958 64217153
Peripheral nerve paresis 11.81 9.89 5 263616 39 64235072
Nephrotic syndrome 11.79 9.89 13 263608 9554 64225557
Eosinophil count increased 11.78 9.89 25 263596 14087 64221024
Physical assault 11.76 9.89 22 263599 1524 64233587
Initial insomnia 11.76 9.89 51 263570 5753 64229358
Chronic fatigue syndrome 11.70 9.89 19 263602 1176 64233935
Pneumoconiosis 11.67 9.89 9 263612 239 64234872
Nodular rash 11.65 9.89 10 263611 310 64234801
Foreign body 11.63 9.89 29 263592 2450 64232661
Infective pulmonary exacerbation of cystic fibrosis 11.52 9.89 19 263602 11777 64223334
Staphylococcal sepsis 11.50 9.89 22 263599 12877 64222234
Benign mesenteric neoplasm 11.45 9.89 3 263618 3 64235108
Cutaneous lymphoma 11.45 9.89 9 263612 246 64234865
Osteomyelitis 11.41 9.89 66 263555 27521 64207590
Vascular headache 11.39 9.89 5 263616 43 64235068
Loss of personal independence in daily activities 11.37 9.89 218 263403 72236 64162875
Product quality issue 11.34 9.89 178 263443 29621 64205490
Disinhibition 11.33 9.89 27 263594 2216 64232895
Suspiciousness 11.30 9.89 13 263608 578 64234533
Reduced facial expression 11.29 9.89 26 263595 2087 64233024
Femoral artery aneurysm 11.29 9.89 8 263613 186 64234925
Periorbital haematoma 11.26 9.89 16 263605 880 64234231
Face injury 11.23 9.89 33 263588 3072 64232039
Foaming at mouth 11.21 9.89 23 263598 1706 64233405
Product substitution 11.18 9.89 6 263615 83 64235028
Photophobia 11.18 9.89 114 263507 17179 64217932
Rash erythematous 11.17 9.89 136 263485 48497 64186614
Paranoia 11.15 9.89 109 263512 16243 64218868
Alcoholism 11.12 9.89 35 263586 3382 64231729
Faeces soft 11.10 9.89 5 263616 5850 64229261
Haematuria 11.07 9.89 177 263444 60294 64174817
Post-traumatic stress disorder 10.98 9.89 40 263581 4165 64230946
Inflammatory marker increased 10.96 9.89 11 263610 8440 64226671
Sudden death 10.93 9.89 128 263493 19968 64215143
Creatinine renal clearance decreased 10.87 9.89 27 263594 14394 64220717
Cholestasis 10.86 9.89 250 263371 44622 64190489
Multiple sclerosis relapse 10.84 9.89 232 263389 40903 64194208
Hypoventilation 10.84 9.89 51 263570 5955 64229156
Electroencephalogram abnormal 10.76 9.89 46 263575 5157 64229954
Myoclonus 10.71 9.89 153 263468 24965 64210146
Skin necrosis 10.66 9.89 27 263594 14302 64220809
Death of relative 10.62 9.89 8 263613 205 64234906
Cyclothymic disorder 10.62 9.89 8 263613 205 64234906
Myositis 10.60 9.89 33 263588 16344 64218767
Central nervous system necrosis 10.59 9.89 9 263612 275 64234836
Skin toxicity 10.54 9.89 7 263614 6595 64228516
Apraxia 10.48 9.89 28 263593 2467 64232644
Thrombotic microangiopathy 10.47 9.89 34 263587 16621 64218490
Food allergy 10.43 9.89 10 263611 7841 64227270
Enterococcal infection 10.42 9.89 26 263595 13840 64221271
Frequent bowel movements 10.41 9.89 39 263582 18266 64216845
Tumour hyperprogression 10.37 9.89 7 263614 150 64234961
Biliary dyskinesia 10.35 9.89 27 263594 2345 64232766
Pneumonia viral 10.35 9.89 10 263611 7812 64227299
Wound infection 10.31 9.89 29 263592 14835 64220276
Gallbladder hypofunction 10.27 9.89 11 263610 451 64234660
Progressive multifocal leukoencephalopathy 10.27 9.89 39 263582 18193 64216918
Accidental poisoning 10.22 9.89 20 263601 1433 64233678
Fistula 10.22 9.89 15 263606 9746 64225365
Injection site pruritus 10.19 9.89 102 263519 37724 64197387
Hypophagia 10.15 9.89 108 263513 39479 64195632
Myotonia 10.13 9.89 8 263613 220 64234891
Skin plaque 10.11 9.89 13 263608 8927 64226184
Nephrolithiasis 10.09 9.89 122 263499 43561 64191550
Phobia 10.09 9.89 10 263611 374 64234737
Metastases to bone 10.09 9.89 46 263575 20389 64214722
Dysuria 10.08 9.89 234 263387 41823 64193288
Torsade de pointes 10.07 9.89 112 263509 17251 64217860
Respiratory tract infection 10.02 9.89 101 263520 37306 64197805
Immune thrombocytopenia 10.01 9.89 30 263591 15036 64220075
Conjunctivitis 9.94 9.89 46 263575 20308 64214803
Blood lactic acid increased 9.93 9.89 17 263604 10384 64224727
Laparoscopy 9.93 9.89 3 263618 7 64235104

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N05BA12 NERVOUS SYSTEM
PSYCHOLEPTICS
ANXIOLYTICS
Benzodiazepine derivatives
FDA CS M0002356 Benzodiazepines
CHEBI has role CHEBI:35474 anti-anxiety agents
CHEBI has role CHEBI:35623 anticonvulsants
CHEBI has role CHEBI:35703 Xenobiotic
CHEBI has role CHEBI:35717 hypnotics
CHEBI has role CHEBI:51371 muscle relaxants
CHEBI has role CHEBI:51373 gamma-aminobutyric acid receptor agonist
MeSH PA D014151 Anti-Anxiety Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D018682 GABA Agents
MeSH PA D018757 GABA Modulators
MeSH PA D006993 Hypnotics and Sedatives
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D011619 Psychotropic Drugs
MeSH PA D014149 Tranquilizing Agents
FDA EPC N0000175694 Benzodiazepine

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Generalized anxiety disorder indication 21897009 DOID:14320
Anxiety indication 48694002
Mixed anxiety and depressive disorder indication 231504006
Panic disorder indication 371631005 DOID:594
Insomnia off-label use 193462001
Suicidal thoughts contraindication 6471006
Asthenia contraindication 13791008
Alcohol intoxication contraindication 25702006
Depressive disorder contraindication 35489007
Substance abuse contraindication 66214007
Sleep apnea contraindication 73430006 DOID:0050847
Open-angle glaucoma contraindication 84494001 DOID:1067
Kidney disease contraindication 90708001 DOID:557
Disease of liver contraindication 235856003 DOID:409
Syncope contraindication 271594007
Pregnancy, function contraindication 289908002
Angle-closure glaucoma contraindication 392291006 DOID:13550
Breastfeeding (mother) contraindication 413712001
Chronic lung disease contraindication 413839001
Obesity contraindication 414916001 DOID:9970
Central nervous system depression contraindication 418072004
Smokes tobacco daily contraindication 449868002




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 6.15 Basic
pKa2 4.9 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
GABA-A receptor alpha-5/beta-3/gamma-2 Ion channel POSITIVE ALLOSTERIC MODULATOR EC50 8 WOMBAT-PK CHEMBL
GABA-A receptor alpha-1/beta-2/gamma-2 Ion channel POSITIVE ALLOSTERIC MODULATOR EC50 7.43 WOMBAT-PK CHEMBL
GABA-A receptor alpha-2/beta-3/gamma-2 Ion channel POSITIVE ALLOSTERIC MODULATOR EC50 7.92 WOMBAT-PK CHEMBL
GABA-A receptor alpha-3/beta-3/gamma-2 Ion channel POSITIVE ALLOSTERIC MODULATOR EC50 7.16 WOMBAT-PK CHEMBL
Cytochrome P450 3A4 Enzyme Ki 3.85 WOMBAT-PK
Platelet-activating factor receptor GPCR Ki 5.46 PDSP
Bromodomain-containing protein 4 Unclassified Kd 5.61 CHEMBL
Cholecystokinin receptor type A GPCR IC50 4.19 CHEMBL

External reference:

IDSource
D00225 KEGG_DRUG
202363 RXNORM
C0002333 UMLSCUI
CHEBI:2611 CHEBI
08H PDB_CHEM_ID
CHEMBL661 ChEMBL_ID
DB00404 DRUGBANK_ID
D000525 MESH_DESCRIPTOR_UI
2118 PUBCHEM_CID
7111 IUPHAR_LIGAND_ID
3426 INN_ID
YU55MQ3IZY UNII
1327 MMSL
1885 MMSL
4153 MMSL
d00168 MMSL
001464 NDDF
4018074 VANDF
111127002 SNOMEDCT_US
386983007 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Xanax HUMAN PRESCRIPTION DRUG LABEL 1 0009-0029 TABLET 0.25 mg ORAL NDA 36 sections
Xanax HUMAN PRESCRIPTION DRUG LABEL 1 0009-0055 TABLET 0.50 mg ORAL NDA 36 sections
Xanax XR HUMAN PRESCRIPTION DRUG LABEL 1 0009-0057 TABLET, EXTENDED RELEASE 0.50 mg ORAL NDA 37 sections
Xanax XR HUMAN PRESCRIPTION DRUG LABEL 1 0009-0057 TABLET, EXTENDED RELEASE 0.50 mg ORAL NDA 37 sections
Xanax XR HUMAN PRESCRIPTION DRUG LABEL 1 0009-0059 TABLET, EXTENDED RELEASE 1 mg ORAL NDA 37 sections
Xanax XR HUMAN PRESCRIPTION DRUG LABEL 1 0009-0059 TABLET, EXTENDED RELEASE 1 mg ORAL NDA 37 sections
Xanax XR HUMAN PRESCRIPTION DRUG LABEL 1 0009-0066 TABLET, EXTENDED RELEASE 2 mg ORAL NDA 37 sections
Xanax XR HUMAN PRESCRIPTION DRUG LABEL 1 0009-0066 TABLET, EXTENDED RELEASE 2 mg ORAL NDA 37 sections
Xanax XR HUMAN PRESCRIPTION DRUG LABEL 1 0009-0068 TABLET, EXTENDED RELEASE 3 mg ORAL NDA 37 sections
Xanax XR HUMAN PRESCRIPTION DRUG LABEL 1 0009-0068 TABLET, EXTENDED RELEASE 3 mg ORAL NDA 37 sections
Xanax HUMAN PRESCRIPTION DRUG LABEL 1 0009-0090 TABLET 1 mg ORAL NDA 36 sections
Xanax HUMAN PRESCRIPTION DRUG LABEL 1 0009-0094 TABLET 2 mg ORAL NDA 36 sections
Alprazolam HUMAN PRESCRIPTION DRUG LABEL 1 0054-3068 SOLUTION, CONCENTRATE 1 mg ORAL ANDA 16 sections
Alprazolam HUMAN PRESCRIPTION DRUG LABEL 1 0228-2027 TABLET 0.25 mg ORAL ANDA 29 sections
Alprazolam HUMAN PRESCRIPTION DRUG LABEL 1 0228-2027 TABLET 0.25 mg ORAL ANDA 29 sections
Alprazolam HUMAN PRESCRIPTION DRUG LABEL 1 0228-2029 TABLET 0.50 mg ORAL ANDA 29 sections
Alprazolam HUMAN PRESCRIPTION DRUG LABEL 1 0228-2029 TABLET 0.50 mg ORAL ANDA 29 sections
Alprazolam HUMAN PRESCRIPTION DRUG LABEL 1 0228-2031 TABLET 1 mg ORAL ANDA 29 sections
Alprazolam HUMAN PRESCRIPTION DRUG LABEL 1 0228-2031 TABLET 1 mg ORAL ANDA 29 sections
Alprazolam HUMAN PRESCRIPTION DRUG LABEL 1 0228-2039 TABLET 2 mg ORAL ANDA 29 sections
Alprazolam HUMAN PRESCRIPTION DRUG LABEL 1 0228-2039 TABLET 2 mg ORAL ANDA 29 sections
AlprazolamExtended Release HUMAN PRESCRIPTION DRUG LABEL 1 0228-3083 TABLET, EXTENDED RELEASE 0.50 mg ORAL ANDA 29 sections
AlprazolamExtended Release HUMAN PRESCRIPTION DRUG LABEL 1 0228-3084 TABLET, EXTENDED RELEASE 1 mg ORAL ANDA 29 sections
AlprazolamExtended Release HUMAN PRESCRIPTION DRUG LABEL 1 0228-3086 TABLET, EXTENDED RELEASE 3 mg ORAL ANDA 29 sections
AlprazolamExtended Release HUMAN PRESCRIPTION DRUG LABEL 1 0228-3087 TABLET, EXTENDED RELEASE 2 mg ORAL ANDA 29 sections
Alprazolam HUMAN PRESCRIPTION DRUG LABEL 1 0228-4019 TABLET, ORALLY DISINTEGRATING 0.25 mg ORAL ANDA 31 sections
Alprazolam HUMAN PRESCRIPTION DRUG LABEL 1 0228-4022 TABLET, ORALLY DISINTEGRATING 0.50 mg ORAL ANDA 31 sections
Alprazolam HUMAN PRESCRIPTION DRUG LABEL 1 0228-4024 TABLET, ORALLY DISINTEGRATING 1 mg ORAL ANDA 31 sections
Alprazolam HUMAN PRESCRIPTION DRUG LABEL 1 0228-4025 TABLET, ORALLY DISINTEGRATING 2 mg ORAL ANDA 31 sections
Alprazolam HUMAN PRESCRIPTION DRUG LABEL 1 0615-8215 TABLET 0.25 mg ORAL ANDA 29 sections