alprazolam 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
diazepam derivatives 136 28981-97-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • xanax
  • alprazolam
  • alprozolam
  • alzolam
A triazolobenzodiazepine compound with antianxiety and sedative-hypnotic actions, that is efficacious in the treatment of PANIC DISORDERS, with or without AGORAPHOBIA, and in generalized ANXIETY DISORDERS. (From AMA Drug Evaluations Annual, 1994, p238)
  • Molecular weight: 308.77
  • Formula: C17H13ClN4
  • CLOGP: 2.56
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 0
  • TPSA: 43.07
  • ALOGS: -3.98
  • ROTB: 1
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
1 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.07 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 20 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.46 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 88 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.80 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 0.74 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.29 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 12 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 2.259 Moderate 0.76
caco2-efflux Caco-2 efflux ratio (BA/AB) 0.753 Moderate 0.76
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 62.951 10^-6 cm/s Moderate 0.76
dh-clint Dog hepatocyte intrinsic clearance 8.433 uL/min/10^6 cells Moderate 0.76
dppb Dog plasma protein binding (% unbound) 27.640 % Moderate 0.76
fcs-ppb Fetal calf serum protein binding (% unbound) 53.280 % Moderate 0.76
herg hERG pIC50 4.592 pIC50 Moderate 0.76
hh-clint Human hepatocyte intrinsic clearance 2.009 uL/min/10^6 cells Moderate 0.76
hlm-clint Human liver microsomal intrinsic clearance 6.871 uL/min/mg protein Moderate 0.76
hppb Human plasma protein binding (% unbound) 27.500 % Moderate 0.76
kinase-safety-class ACVR2B,AXL,BRAF,CAMK2D,CDK5,CDK9,EIF2AK3,ERBB2,GRK2,ITK,MAPK10,MAPK7,PDK4,PIK3CG,PRKDC 15
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 1.330 Moderate 0.76
mh-clint Mouse hepatocyte intrinsic clearance 13.900 Moderate 0.76
mppb Mouse plasma protein binding (% unbound) 28.150 Moderate 0.76
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 7.727 Moderate 0.76
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 34.210 % Moderate 0.76
rh-clint Rat hepatocyte intrinsic clearance 45.082 uL/min/10^6 cells Moderate 0.76
rh-fuinc Rat hepatocyte fraction unbound in incubation 77.250 % Moderate 0.76
rppb Rat plasma protein binding (% unbound) 25.610 % Moderate 0.76
solubility-dd Solubility at pH 7.4 in DMSO 511.682 uM Moderate 0.76

Approvals:

DateAgencyCompanyOrphan
Oct. 16, 1981 FDA PHARMACIA AND UPJOHN

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug abuse 7258.59 9.44 4014 281977 78333 90264123
Completed suicide 5908.51 9.44 4341 281650 140717 90201739
Toxicity to various agents 3000.93 9.44 4097 281894 283749 90058707
Sopor 2701.51 9.44 1391 284600 23253 90319203
Suicide attempt 1858.98 9.44 1687 284304 73712 90268744
Intentional overdose 1786.89 9.44 1821 284170 92013 90250443
Respiratory arrest 1639.22 9.44 1121 284870 32190 90310266
Coma 1361.46 9.44 1398 284593 71234 90271222
Poisoning deliberate 1355.14 9.44 769 285222 15717 90326739
Poisoning 1338.27 9.44 742 285249 14475 90327981
Cardio-respiratory arrest 1333.98 9.44 1297 284694 61843 90280613
Cardiac arrest 1038.03 9.44 1459 284532 103476 90238980
Somnolence 997.07 9.44 2102 283889 206982 90135474
Pemphigus 986.43 9.44 8 285983 326856 90015600
Drug dependence 956.86 9.44 771 285220 28556 90313900
Overdose 942.10 9.44 1743 284248 155966 90186490
Hand deformity 851.56 9.44 17 285974 296345 90046111
Systemic lupus erythematosus 795.52 9.44 102 285889 361794 89980662
Synovitis 751.84 9.44 82 285909 329670 90012786
Glossodynia 751.80 9.44 73 285918 321706 90020750
Intentional product misuse 725.06 9.44 1134 284857 88470 90253986
Anti-cyclic citrullinated peptide antibody positive 722.15 9.44 4 285987 236429 90106027
Pericarditis 685.21 9.44 42 285949 270109 90072347
Intentional self-injury 677.04 9.44 633 285358 28701 90313755
Drug use disorder 671.68 9.44 384 285607 7959 90334497
Helicobacter infection 651.61 9.44 13 285978 226837 90115619
Folliculitis 574.15 9.44 15 285976 204338 90138118
Lower respiratory tract infection 566.99 9.44 64 285927 250595 90091861
Arthropathy 544.70 9.44 237 285754 366005 89976451
Maternal exposure during pregnancy 489.72 9.44 263 285728 359800 89982656
Wound 488.42 9.44 173 285818 302807 90039649
Swelling 472.59 9.44 378 285613 418680 89923776
Muscle injury 468.11 9.44 21 285970 176633 90165823
Rheumatic fever 465.35 9.44 3 285988 153118 90189338
Contraindicated product administered 437.99 9.44 232 285759 319907 90022549
Joint swelling 430.83 9.44 575 285416 502725 89839731
Suicidal ideation 404.32 9.44 787 285204 73068 90269388
Drug withdrawal syndrome 394.44 9.44 470 285521 28253 90314203
Alopecia 392.60 9.44 597 285394 494474 89847982
Drug intolerance 385.37 9.44 509 285482 447082 89895374
Irritable bowel syndrome 374.89 9.44 96 285895 207352 90135104
Impaired healing 373.48 9.44 136 285855 234063 90108393
Sleep disorder due to general medical condition, insomnia type 370.97 9.44 7 285984 128687 90213769
Abdominal discomfort 365.70 9.44 589 285402 476739 89865717
Discomfort 361.85 9.44 208 285783 274127 90068329
C-reactive protein abnormal 355.45 9.44 10 285981 127419 90215037
Rheumatoid factor positive 354.49 9.44 58 285933 171592 90170864
Nasopharyngitis 354.46 9.44 459 285532 406645 89935811
Bradyphrenia 352.73 9.44 247 285744 7365 90335091
Psoriatic arthropathy 334.14 9.44 151 285840 228184 90114272
Loss of consciousness 328.60 9.44 1082 284909 139156 90203300
Liver injury 325.85 9.44 70 285921 170497 90171959
Substance abuse 321.81 9.44 205 285786 5201 90337255
Mydriasis 317.96 9.44 309 285682 14703 90327753
Treatment failure 310.03 9.44 301 285690 303627 90038829
Infusion related reaction 309.17 9.44 525 285466 416255 89926201
Type 2 diabetes mellitus 309.16 9.44 127 285864 203117 90139339
Agitation 305.86 9.44 663 285328 66435 90276021
Blister 301.28 9.44 219 285772 254779 90087677
Death 293.87 9.44 2451 283540 454100 89888356
Stomatitis 288.42 9.44 265 285726 274433 90068023
Withdrawal syndrome 279.17 9.44 350 285641 22174 90320282
Anxiety 276.42 9.44 1798 284193 307974 90034482
Altered state of consciousness 274.48 9.44 413 285578 31119 90311337
Therapeutic product effect decreased 271.54 9.44 285 285706 277286 90065170
Ill-defined disorder 270.90 9.44 122 285869 184769 90157687
Wheezing 265.30 9.44 217 285774 237863 90104593
General physical health deterioration 264.51 9.44 446 285545 354669 89987787
Facet joint syndrome 262.90 9.44 11 285980 98378 90244078
Macular degeneration 258.88 9.44 445 285546 37525 90304931
Off label use 253.49 9.44 2244 283747 1100008 89242448
Breast cancer stage III 250.15 9.44 3 285988 84444 90258012
Lip dry 249.01 9.44 18 285973 100937 90241519
Gastrointestinal disorder 248.33 9.44 266 285725 256421 90086035
Hepatic enzyme increased 247.22 9.44 477 285514 360259 89982197
Joint range of motion decreased 244.56 9.44 63 285928 135580 90206876
Rheumatoid arthritis 242.87 9.44 486 285505 362128 89980328
Wound infection 240.88 9.44 27 285964 106375 90236081
Peripheral swelling 238.13 9.44 601 285390 412505 89929951
Tremor 236.94 9.44 1035 284956 152138 90190318
Panic attack 236.17 9.44 350 285641 26015 90316441
Grip strength decreased 235.74 9.44 14 285977 92562 90249894
Hypersensitivity 234.80 9.44 698 285293 453979 89888477
Mobility decreased 231.41 9.44 270 285721 250464 90091992
Depressed level of consciousness 228.62 9.44 623 285368 72161 90270295
Infection 226.82 9.44 504 285487 361590 89980866
Exposure via ingestion 226.12 9.44 127 285864 2540 90339916
Blood cholesterol increased 217.90 9.44 201 285790 207811 90134645
Depression 206.74 9.44 1639 284352 298962 90043494
Musculoskeletal stiffness 201.46 9.44 394 285597 296138 90046318
Fibromyalgia 199.19 9.44 214 285777 206055 90136401
Live birth 192.55 9.44 15 285976 79092 90263364
Victim of chemical submission 191.13 9.44 76 285915 663 90341793
Peripheral venous disease 190.70 9.44 21 285970 83900 90258556
Drug ineffective 186.38 9.44 3164 282827 1381134 88961322
Arthralgia 185.14 9.44 1570 284421 776952 89565504
Drug interaction 183.89 9.44 1496 284495 274957 90067499
Prescription form tampering 181.89 9.44 73 285918 654 90341802
Sinusitis 181.88 9.44 520 285471 342568 89999888
Fall 181.51 9.44 2319 283672 479491 89862965
Sedation 180.86 9.44 441 285550 47730 90294726
Suspected suicide 171.59 9.44 180 285811 9388 90333068
Disturbance in attention 168.13 9.44 423 285568 46686 90295770
Bradykinesia 165.34 9.44 151 285840 6637 90335819
Feeling abnormal 163.46 9.44 994 284997 166241 90176215
Product use issue 160.59 9.44 520 285471 329399 90013057
Miosis 160.49 9.44 173 285818 9311 90333145
Hypotension 158.67 9.44 1647 284344 323750 90018706
Hypercholesterolaemia 155.06 9.44 62 285929 100830 90241626
Urticaria 148.69 9.44 498 285493 312236 90030220
Intentional product use issue 148.28 9.44 287 285704 216605 90125851
Autoimmune disorder 147.53 9.44 31 285960 76713 90265743
Osteoarthritis 146.35 9.44 245 285746 195485 90146971
Bone erosion 144.81 9.44 5 285986 53016 90289440
Adjustment disorder with depressed mood 143.23 9.44 9 285982 56744 90285712
Knee arthroplasty 139.99 9.44 44 285947 83138 90259318
Myelosuppression 139.87 9.44 7 285984 53584 90288872
C-reactive protein increased 139.40 9.44 223 285768 181166 90161290
Disorientation 137.90 9.44 377 285614 43737 90298719
Dissociation 136.20 9.44 135 285856 6580 90335876
Hyponatraemia 135.76 9.44 802 285189 132736 90209720
Hip arthroplasty 134.30 9.44 37 285954 76171 90266285
Bradypnoea 134.24 9.44 114 285877 4544 90337912
Inflammation 133.10 9.44 224 285767 178368 90164088
Rash 131.62 9.44 1747 284244 794353 89548103
Hyperhidrosis 130.54 9.44 806 285185 135499 90206957
Hepatocellular injury 126.10 9.44 281 285710 28677 90313779
X-ray abnormal 125.06 9.44 4 285987 45420 90297036
Substance use disorder 121.23 9.44 77 285914 1943 90340513
Product use in unapproved indication 121.09 9.44 597 285394 335639 90006817
Alcohol abuse 118.30 9.44 76 285915 1957 90340499
Lower limb fracture 117.00 9.44 61 285930 84952 90257504
Crying 116.36 9.44 253 285738 25392 90317064
Constipation 115.93 9.44 1374 284617 279021 90063435
Drug screen positive 114.57 9.44 95 285896 3662 90338794
Nervousness 114.48 9.44 299 285692 33757 90308699
Night sweats 114.12 9.44 143 285848 128623 90213833
Electrocardiogram QT prolonged 113.02 9.44 491 285500 71965 90270491
Liver function test increased 110.82 9.44 65 285926 84790 90257666
Vertigo 110.37 9.44 475 285516 69336 90273120
Sciatica 109.66 9.44 95 285896 101287 90241169
Lupus-like syndrome 109.03 9.44 13 285978 48833 90293623
Liver disorder 108.18 9.44 134 285857 121135 90221321
Accidental overdose 106.29 9.44 259 285732 28014 90314442
Hallucination, auditory 105.97 9.44 185 285806 15790 90326666
Nail disorder 105.36 9.44 28 285963 59039 90283417
Dependence 104.17 9.44 71 285920 2024 90340432
Onychomadesis 103.27 9.44 12 285979 45986 90296470
Therapy non-responder 102.27 9.44 171 285820 136533 90205923
Bradycardia 101.51 9.44 528 285463 83319 90259137
Drug abuser 101.29 9.44 77 285914 2613 90339843
Gait inability 99.89 9.44 194 285797 146262 90196194
Hypokinesia 99.25 9.44 178 285813 15519 90326937
Psychomotor skills impaired 98.97 9.44 78 285913 2794 90339662
Psychomotor hyperactivity 96.44 9.44 157 285834 12656 90329800
Persistent genital arousal disorder 95.87 9.44 46 285945 654 90341802
Condition aggravated 94.97 9.44 1316 284675 594229 89748227
Drug-induced liver injury 94.84 9.44 87 285904 90231 90252225
Urinary retention 94.45 9.44 298 285693 37446 90305010
Cardiogenic shock 93.97 9.44 226 285765 24242 90318214
Abnormal behaviour 93.43 9.44 215 285776 22413 90320043
Oedema 93.06 9.44 322 285669 199973 90142483
Adverse drug reaction 91.99 9.44 141 285850 116560 90225896
Hallucinations, mixed 91.98 9.44 103 285888 5786 90336670
Respiratory depression 91.38 9.44 171 285820 15404 90327052
Foot deformity 91.09 9.44 37 285954 59614 90282842
Blepharospasm 90.35 9.44 31 285960 55414 90287042
Sleep disorder 90.23 9.44 321 285670 197709 90144747
Anhedonia 90.05 9.44 143 285848 11288 90331168
Irritability 89.64 9.44 282 285709 35380 90307076
Hallucination 89.50 9.44 429 285562 65530 90276926
Drug hypersensitivity 89.13 9.44 984 285007 462625 89879831
Aggression 88.48 9.44 233 285758 26435 90316021
Serotonin syndrome 87.46 9.44 291 285700 37596 90304860
Taste disorder 86.42 9.44 43 285948 61503 90280953
Bezoar 85.18 9.44 70 285921 2664 90339792
Obesity 83.62 9.44 127 285864 105380 90237076
Musculoskeletal pain 82.49 9.44 271 285720 170980 90171476
Speech disorder 81.37 9.44 322 285669 45263 90297193
Chronic sinusitis 80.03 9.44 209 285782 23593 90318863
Vaginal flatulence 79.50 9.44 143 285848 12495 90329961
Seizure 78.80 9.44 782 285209 151847 90190609
Anticholinergic syndrome 76.74 9.44 66 285925 2677 90339779
Injury 75.92 9.44 342 285649 197007 90145449
Proctitis 75.55 9.44 156 285835 15103 90327353
Victim of crime 75.22 9.44 42 285949 830 90341626
Wrong patient received product 74.43 9.44 72 285919 3405 90339051
Onychomycosis 74.13 9.44 14 285977 37362 90305094
Foetal death 73.85 9.44 186 285805 20537 90321919
Emotional distress 72.87 9.44 268 285723 36394 90306062
Euphoric mood 71.77 9.44 87 285904 5322 90337134
Pulmonary fibrosis 71.06 9.44 145 285846 107358 90235098
Insomnia 71 9.44 1461 284530 332013 90010443
Lung disorder 70.94 9.44 239 285752 149644 90192812
Febrile neutropenia 70.59 9.44 259 285732 158090 90184366
Radiculopathy 70.07 9.44 170 285821 18335 90324121
Hepatic cirrhosis 69.96 9.44 58 285933 63195 90279261
Pneumonia 69.71 9.44 1509 284482 636550 89705906
Contusion 69.61 9.44 485 285506 250731 90091725
Laryngitis 68.97 9.44 37 285954 50716 90291740
Alcohol poisoning 68.20 9.44 53 285938 1859 90340597
Finger deformity 68.14 9.44 11 285980 32886 90309570
Thinking abnormal 67.82 9.44 128 285863 11604 90330852
Stupor 67.63 9.44 85 285906 5397 90337059
Hypoglycaemia 67.45 9.44 414 285577 69434 90273022
Hallucination, visual 65.94 9.44 191 285800 22901 90319555
Sinus tachycardia 65.81 9.44 219 285772 28294 90314162
Drug resistance 65.79 9.44 9 285982 30440 90312016
Unresponsive to stimuli 65.42 9.44 266 285725 37855 90304601
Exposure during pregnancy 65.20 9.44 462 285529 237948 90104508
Vaginal discharge 64.51 9.44 170 285821 19294 90323162
Abnormal dreams 64.06 9.44 122 285869 11135 90331321
Rhabdomyolysis 63.58 9.44 325 285666 50931 90291525
Nightmare 63.30 9.44 181 285810 21544 90320912
Mental disorder 63.19 9.44 235 285756 32083 90310373
Respiratory acidosis 63.17 9.44 101 285890 8018 90334438
Homicide 62.82 9.44 27 285964 292 90342164
Osmolar gap increased 62.45 9.44 23 285968 159 90342297
Psychomotor retardation 61.88 9.44 76 285915 4713 90337743
Bursitis 60.90 9.44 212 285779 131442 90211014
Paraesthesia oral 60.89 9.44 229 285762 31430 90311026
Procedural pain 60.63 9.44 237 285754 33123 90309333
Head injury 58.67 9.44 224 285767 30964 90311492
Female genital tract fistula 58.14 9.44 155 285836 17713 90324743
Pregnancy 58.06 9.44 66 285925 61981 90280475
Thermal burn 58.03 9.44 88 285903 6674 90335782
Fear 57.99 9.44 148 285843 16474 90325982
Red blood cell sedimentation rate increased 57.53 9.44 108 285883 82487 90259969
Parkinsonism 57.36 9.44 133 285858 13932 90328524
Anger 57.35 9.44 131 285860 13589 90328867
Restlessness 57.18 9.44 244 285747 35476 90306980
Cognitive disorder 56.42 9.44 394 285597 69013 90273443
Joint dislocation 55.64 9.44 36 285955 44546 90297910
Temperature regulation disorder 55.27 9.44 134 285857 14445 90328011
Hypotonia 54.45 9.44 115 285876 11311 90331145
Product complaint 54.34 9.44 127 285864 13373 90329083
Dry mouth 54.15 9.44 349 285642 183710 90158746
Joint stiffness 53.52 9.44 103 285888 77939 90264517
Multiple sclerosis relapse 52.39 9.44 313 285678 51992 90290464
Hypoaesthesia 51.89 9.44 689 285302 313521 90028935
Cholecystitis chronic 51.67 9.44 103 285888 9723 90332733
Mania 51.62 9.44 128 285863 13996 90328460
Dysarthria 51.39 9.44 321 285670 54161 90288295
Dysphoria 51.28 9.44 79 285912 6075 90336381
Back pain 51.20 9.44 1337 284654 315838 90026618
Walking aid user 51.08 9.44 24 285967 35482 90306974
Depressed mood 49.96 9.44 300 285691 49922 90292534
Dysuria 49.68 9.44 251 285740 39150 90303306
Lethargy 49.33 9.44 355 285636 62784 90279672
Adverse event 48.50 9.44 198 285793 117220 90225236
Mental status changes 48.41 9.44 273 285718 44406 90298050
Exostosis 48.12 9.44 58 285933 53076 90289380
Obsessive-compulsive disorder 48.03 9.44 65 285926 4439 90338017
Normal newborn 47.96 9.44 8 285983 23354 90319102
Respiratory rate decreased 47.93 9.44 61 285930 3922 90338534
Pupillary disorder 47.08 9.44 21 285970 250 90342206
Initial insomnia 47.06 9.44 96 285895 9214 90333242
Inappropriate antidiuretic hormone secretion 46.98 9.44 152 285839 19353 90323103
Erythema 46.67 9.44 998 284993 228248 90114208
Suicidal behaviour 46.59 9.44 51 285940 2793 90339663
Ataxia 46.57 9.44 144 285847 17898 90324558
Epilepsy 46.17 9.44 121 285870 82085 90260371
Pneumonia aspiration 45.59 9.44 252 285739 40688 90301768
Hypothermia 44.64 9.44 129 285862 15446 90327010
Syncope 44.58 9.44 626 285365 132037 90210419
Major depression 44.39 9.44 98 285893 9937 90332519
Electrocardiogram QRS complex prolonged 43.51 9.44 81 285910 7267 90335189
Sluggishness 43.48 9.44 72 285919 5887 90336569
Stress 42.94 9.44 419 285572 80976 90261480
Dehydration 42.69 9.44 856 285135 193591 90148865
Prescription drug used without a prescription 42.61 9.44 52 285939 3203 90339253
Impaired driving ability 42.53 9.44 66 285925 5107 90337349
Hypersomnia 42.46 9.44 157 285834 21374 90321082
Ulcer haemorrhage 42.40 9.44 15 285976 26306 90316150
Chemical submission 41.60 9.44 24 285967 506 90341950
Cholestasis 41.47 9.44 225 285766 36074 90306382
Pyrexia 41.23 9.44 1685 284306 658800 89683656
Premature delivery 41.09 9.44 37 285954 38725 90303731
Generalised tonic-clonic seizure 41.00 9.44 218 285773 34685 90307771
Abdominal pain upper 40.95 9.44 771 285220 331903 90010553
Sinus bradycardia 40.73 9.44 132 285859 16820 90325636
Multiple injuries 40.64 9.44 39 285952 1826 90340630
Infusion site reaction 40.26 9.44 6 285985 19033 90323423
Incoherent 40.22 9.44 63 285928 4914 90337542
Oral candidiasis 39.99 9.44 219 285772 35236 90307220
Ear infection 39.72 9.44 102 285889 69673 90272783
Hyporesponsive to stimuli 39.44 9.44 36 285955 1581 90340875
Multiple sclerosis 39.16 9.44 183 285808 27657 90314799
Gastrooesophageal reflux disease 39.07 9.44 336 285655 166001 90176455
Pustular psoriasis 38.89 9.44 6 285985 18550 90323906
Analgesic drug level increased 38.81 9.44 47 285944 2872 90339584
Panic disorder 37.95 9.44 48 285943 3067 90339389
Malignant neoplasm progression 37.69 9.44 191 285800 106679 90235777
Neutropenic sepsis 37.69 9.44 6 285985 18124 90324332
Coma scale abnormal 37.11 9.44 65 285926 5561 90336895
Renal papillary necrosis 36.90 9.44 18 285973 266 90342190
Neuroleptic malignant syndrome 36.68 9.44 118 285873 14978 90327478
Mood altered 36.34 9.44 128 285863 17016 90325440
Balance disorder 36.28 9.44 467 285524 96613 90245843
Housebound 36.25 9.44 17 285974 229 90342227
Pruritus 36.05 9.44 1371 284620 540154 89802302
Cyanosis 35.99 9.44 139 285852 19316 90323140
Anion gap increased 35.96 9.44 40 285951 2230 90340226
Cough 35.88 9.44 888 285103 368074 89974382
Blood pressure diastolic decreased 35.80 9.44 20 285971 26806 90315650
Accidental death 35.78 9.44 38 285953 2010 90340446
Compartment syndrome 35.68 9.44 45 285946 2867 90339589
Deep vein thrombosis 35.63 9.44 444 285547 91176 90251280
Weight increased 35.63 9.44 1025 284966 416902 89925554
Adjustment disorder with mixed anxiety and depressed mood 35.32 9.44 14 285977 121 90342335
Inadequate analgesia 35.10 9.44 47 285944 3177 90339279
Arthritis 34.97 9.44 348 285643 166967 90175489
Bundle branch block right 34.68 9.44 62 285929 5391 90337065
Chronic obstructive pulmonary disease 34.62 9.44 371 285620 73458 90268998
Apraxia 34.37 9.44 39 285952 2223 90340233
Maternal exposure timing unspecified 34.23 9.44 14 285977 22469 90319987
Vision blurred 34.11 9.44 513 285478 109780 90232676
Extrapyramidal disorder 33.94 9.44 121 285870 16182 90326274
Alcohol use 33.86 9.44 34 285957 1683 90340773
Somnambulism 33.61 9.44 66 285925 6162 90336294
Substance abuser 33.37 9.44 15 285976 182 90342274
Muscle rigidity 33.11 9.44 110 285881 14199 90328257
Therapeutic product effect incomplete 32.78 9.44 423 285568 193473 90148983
Product substitution issue 32.77 9.44 128 285863 17880 90324576
Emotional disorder 32.68 9.44 113 285878 14884 90327572
Asthma 32.39 9.44 553 285438 241607 90100849
Feeling of despair 32.30 9.44 45 285946 3159 90339297
Blood cholesterol decreased 32.28 9.44 35 285956 1896 90340560
Drug withdrawal convulsions 31.99 9.44 31 285960 1469 90340987
Substance use 31.83 9.44 28 285963 1171 90341285
Bipolar I disorder 31.81 9.44 36 285955 2046 90340410
Panic reaction 31.77 9.44 55 285936 4662 90337794
Post-traumatic stress disorder 31.70 9.44 68 285923 6760 90335696
Back injury 31.56 9.44 62 285929 46560 90295896
Pain in extremity 31.45 9.44 1134 284857 449395 89893061
Hypokalaemia 31.41 9.44 585 285406 130531 90211925
Burning sensation 31.23 9.44 322 285669 63130 90279326
Cytomegalovirus infection 31.18 9.44 23 285968 26579 90315877
Nausea 31.01 9.44 3977 282014 1106339 89236117
Immobilisation prolonged 30.97 9.44 13 285978 132 90342324
Victim of sexual abuse 30.92 9.44 22 285969 673 90341783
Delusion 30.79 9.44 105 285886 13735 90328721
Pulmonary embolism 30.76 9.44 582 285409 130238 90212218
Bipolar disorder 30.31 9.44 79 285912 8906 90333550
Logorrhoea 30.07 9.44 40 285951 2687 90339769
Underdose 29.96 9.44 80 285911 53937 90288519
Toxicologic test abnormal 29.90 9.44 22 285969 710 90341746
Adverse reaction 29.58 9.44 30 285961 29682 90312774
Apathy 29.32 9.44 89 285902 10951 90331505
Dyspnoea 29.31 9.44 2388 283603 878567 89463889
Bronchiectasis 29.30 9.44 17 285974 22313 90320143
Gallbladder disorder 29.21 9.44 132 285859 19671 90322785
Dyskinesia 28.87 9.44 206 285785 36328 90306128
Poverty of speech 28.85 9.44 16 285975 312 90342144
Slow speech 28.81 9.44 33 285958 1900 90340556
Blood creatine phosphokinase increased 28.75 9.44 195 285796 33828 90308628
Mucosal inflammation 28.56 9.44 90 285901 57535 90284921
Encephalopathy 28.50 9.44 247 285744 46197 90296259
Disinhibition 28.47 9.44 25 285966 1043 90341413
Peripheral circulatory failure 28.45 9.44 30 285961 1574 90340882
Hypochloraemia 28.21 9.44 38 285953 2584 90339872
Alcohol interaction 27.95 9.44 31 285960 1723 90340733
Self-injurious ideation 27.93 9.44 42 285949 3161 90339295
Drug detoxification 27.71 9.44 16 285975 338 90342118
Muscular weakness 27.62 9.44 472 285519 206194 90136262
Neuroglycopenia 27.54 9.44 25 285966 1090 90341366
Therapy partial responder 27.23 9.44 18 285973 22025 90320431
Pancreatitis acute 27.10 9.44 184 285807 31931 90310525
Blood osmolarity increased 27.05 9.44 16 285975 354 90342102
Blood pressure systolic increased 26.94 9.44 94 285897 58251 90284205
Sleep disorder due to a general medical condition 26.56 9.44 64 285927 44674 90297782
Prescribed underdose 26.49 9.44 134 285857 74885 90267571
Persecutory delusion 26.47 9.44 41 285950 3167 90339289
Palpitations 26.14 9.44 590 285401 136138 90206318
Torsade de pointes 26.09 9.44 106 285885 15076 90327380
Food allergy 25.85 9.44 153 285838 25325 90317131
Gun shot wound 25.84 9.44 11 285980 116 90342340
COVID-19 25.79 9.44 376 285615 168467 90173989
Neutrophil count decreased 25.70 9.44 127 285864 71405 90271051
Alcoholism 25.61 9.44 30 285961 1770 90340686
Asphyxia 25.57 9.44 64 285927 7039 90335417
Tarsal tunnel syndrome 25.06 9.44 18 285973 559 90341897
Cerebral haematoma 25.05 9.44 47 285944 4242 90338214
Hyperreflexia 25.04 9.44 61 285930 6596 90335860
Pain 25.01 9.44 2758 283233 993583 89348873
Obstructive airways disorder 24.77 9.44 27 285964 25842 90316614
Haemophagocytic lymphohistiocytosis 24.57 9.44 9 285982 15450 90327006
Conversion disorder 24.47 9.44 32 285959 2114 90340342
Hyponatraemic encephalopathy 24.40 9.44 14 285977 292 90342164
Hallucination, gustatory 24.22 9.44 9 285982 64 90342392
Obsessive thoughts 24.22 9.44 18 285973 590 90341866
Suspected counterfeit product 24.21 9.44 17 285974 509 90341947
Drug withdrawal syndrome neonatal 24.02 9.44 33 285958 2286 90340170
Necrosis ischaemic 23.97 9.44 22 285969 973 90341483
Benzodiazepine drug level abnormal 23.81 9.44 5 285986 0 90342456
Formication 23.74 9.44 49 285942 4742 90337714
Renal failure 23.71 9.44 561 285430 130446 90212010
Headache 23.61 9.44 3087 282904 859659 89482797
Tension 23.59 9.44 42 285949 3640 90338816
Thymus disorder 23.42 9.44 14 285977 316 90342140
Ear pain 23.39 9.44 98 285893 57604 90284852
Tonic clonic movements 23.34 9.44 28 285963 1694 90340762
Gambling disorder 23.25 9.44 24 285967 1228 90341228
Neurosis 23.22 9.44 15 285976 390 90342066
Dysgeusia 23.21 9.44 261 285730 52299 90290157
Feeling jittery 23.08 9.44 103 285888 15268 90327188
Face injury 23.06 9.44 43 285948 3862 90338594
Drug ineffective for unapproved indication 22.99 9.44 120 285871 66524 90275932
Injection site reaction 22.98 9.44 183 285808 91897 90250559
Adrenal insufficiency 22.76 9.44 37 285954 29884 90312572
Retching 22.73 9.44 120 285871 19039 90323417
Therapeutic response unexpected 22.59 9.44 132 285859 21748 90320708
Pre-existing condition improved 22.58 9.44 72 285919 9097 90333359
Areflexia 22.55 9.44 41 285950 3612 90338844
General symptom 22.55 9.44 9 285982 14659 90327797
Cardiac valve disease 22.49 9.44 47 285944 4588 90337868
Treatment noncompliance 22.45 9.44 256 285735 51471 90290985
Partner stress 22.15 9.44 15 285976 423 90342033
Paranoia 22.09 9.44 90 285901 12818 90329638
Staphylococcal infection 22.06 9.44 242 285749 48197 90294259
Myoclonus 22.02 9.44 119 285872 19049 90323407
Developmental delay 22.00 9.44 27 285964 1673 90340783
Wrong technique in product usage process 21.78 9.44 332 285659 71239 90271217
Substance dependence 21.71 9.44 11 285980 177 90342279
Disorganised speech 21.32 9.44 28 285963 1857 90340599
Tachycardia 21.32 9.44 650 285341 157023 90185433
Counterfeit product administered 21.30 9.44 9 285982 93 90342363
Blood pressure diastolic abnormal 21.05 9.44 19 285972 19862 90322594
Transplant rejection 21.02 9.44 7 285984 12751 90329705
Status epilepticus 20.89 9.44 116 285875 18758 90323698
Breath sounds abnormal 20.81 9.44 100 285891 15286 90327170
Mood swings 20.80 9.44 124 285867 20578 90321878
Road traffic accident 20.79 9.44 228 285763 107398 90235058
Cutaneous T-cell dyscrasia 20.72 9.44 8 285983 64 90342392
Disability 20.64 9.44 63 285928 40682 90301774
Blood pressure fluctuation 20.64 9.44 90 285901 52323 90290133
Aplastic anaemia 20.63 9.44 8 285983 13261 90329195
Anxiety disorder 20.57 9.44 47 285944 4875 90337581
Pseudophaeochromocytoma 20.57 9.44 9 285982 102 90342354
Pulmonary congestion 20.56 9.44 118 285873 19315 90323141
Intestinal obstruction 20.50 9.44 193 285798 36938 90305518
Wound complication 20.49 9.44 46 285945 4717 90337739
Device expulsion 20.16 9.44 64 285927 40822 90301634
Nasal mucosal disorder 20.11 9.44 27 285964 1830 90340626
PO2 increased 20.10 9.44 19 285972 873 90341583
Blood lactic acid 19.89 9.44 9 285982 111 90342345
Anion gap 19.62 9.44 21 285970 1121 90341335
Toxic skin eruption 19.54 9.44 100 285891 15674 90326782
Wrong rate 19.52 9.44 10 285981 165 90342291
Homicidal ideation 19.46 9.44 26 285965 1754 90340702
Internal fixation of fracture 19.43 9.44 18 285973 806 90341650
Product physical issue 19.33 9.44 50 285941 5610 90336846
Cardio-respiratory arrest neonatal 19.05 9.44 4 285987 0 90342456
LDL/HDL ratio increased 19.05 9.44 4 285987 0 90342456
Morbid thoughts 18.81 9.44 17 285974 737 90341719
Postmortem blood drug level abnormal 18.69 9.44 11 285980 241 90342215
Purging 18.69 9.44 7 285984 51 90342405
Waxy flexibility 18.51 9.44 9 285982 132 90342324
Sarcomatoid carcinoma 18.43 9.44 6 285985 27 90342429
Uveitis 18.31 9.44 14 285977 15889 90326567
Spondylitis 18.31 9.44 11 285980 14167 90328289
Asthenia 18.18 9.44 1937 284054 531814 89810642
Colitis 18.14 9.44 316 285675 69626 90272830
Osteoporosis 18.05 9.44 206 285785 96325 90246131
Photophobia 18.03 9.44 122 285869 21147 90321309
Prescribed overdose 18.00 9.44 209 285782 97416 90245040
Drug screen negative 17.98 9.44 12 285979 330 90342126
Nodular rash 17.89 9.44 10 285981 198 90342258
Anaphylactic reaction 17.88 9.44 183 285808 87341 90255115
Theft 17.73 9.44 8 285983 98 90342358
Disease progression 17.73 9.44 368 285623 156247 90186209
Nail bed inflammation 17.72 9.44 25 285966 1776 90340680
Coronary artery disease 17.69 9.44 173 285818 33450 90309006
Diffuse large B-cell lymphoma 17.66 9.44 3 285988 8642 90333814
Muscle spasticity 17.62 9.44 55 285936 35267 90307189
Atrioventricular block first degree 17.57 9.44 63 285928 8448 90334008
Dementia 17.40 9.44 132 285859 23729 90318727
Aphasia 17.30 9.44 209 285782 42603 90299853
Feeling drunk 17.26 9.44 43 285948 4715 90337741
Muscle tightness 17.21 9.44 86 285905 13353 90329103
Laryngeal injury 17.18 9.44 5 285986 14 90342442
Pneumonia streptococcal 17.16 9.44 27 285964 2114 90340342
Hyperdynamic left ventricle 17.13 9.44 11 285980 283 90342173
Neutropenia 17.08 9.44 560 285431 224344 90118112
Oxygen saturation decreased 17.00 9.44 452 285539 107031 90235425
Electrocardiogram QRS complex shortened 16.92 9.44 14 285977 538 90341918
Blood triglycerides increased 16.88 9.44 87 285904 13674 90328782
Vascular headache 16.87 9.44 6 285985 37 90342419
Acquired amegakaryocytic thrombocytopenia 16.87 9.44 6 285985 37 90342419
Shock haemorrhagic 16.86 9.44 80 285911 12165 90330291
Renal impairment 16.71 9.44 233 285758 105188 90237268
Erythrodermic psoriasis 16.69 9.44 19 285972 1087 90341369
Phobia 16.61 9.44 12 285979 376 90342080
Obsessive-compulsive personality disorder 16.45 9.44 5 285986 17 90342439
Ligament sprain 16.34 9.44 90 285901 14509 90327947
Hemianopia 16.34 9.44 26 285965 2056 90340400
Cholecystectomy 16.33 9.44 77 285914 11678 90330778
Pulmonary toxicity 16.27 9.44 8 285983 11523 90330933
Graft versus host disease 16.26 9.44 3 285988 8141 90334315
Reduced facial expression 16.20 9.44 29 285962 2524 90339932
Gallbladder hypofunction 16.18 9.44 13 285978 479 90341977
Generalised anxiety disorder 15.91 9.44 30 285961 2717 90339739
Melaena 15.91 9.44 174 285817 34623 90307833
Trismus 15.87 9.44 42 285949 4779 90337677
Burning mouth syndrome 15.84 9.44 14 285977 589 90341867
Biliary dyskinesia 15.83 9.44 29 285962 2570 90339886
Expired product administered 15.82 9.44 53 285938 6869 90335587
Hyperventilation 15.81 9.44 52 285939 6676 90335780
Product residue present 15.80 9.44 39 285952 4252 90338204
Acute pulmonary oedema 15.77 9.44 66 285925 9514 90332942
Creatinine renal clearance decreased 15.70 9.44 22 285969 18877 90323579
Coma scale 15.65 9.44 6 285985 47 90342409
Polyarthritis 15.61 9.44 21 285970 18329 90324127
Atrioventricular block 15.51 9.44 62 285929 8753 90333703
Multiple drug therapy 15.44 9.44 53 285938 6956 90335500
Coagulation factor decreased 15.42 9.44 9 285982 194 90342262
Tubulointerstitial nephritis and uveitis syndrome 15.41 9.44 10 285981 262 90342194
Attention deficit hyperactivity disorder 15.38 9.44 38 285953 4146 90338310
Cytomegalovirus infection reactivation 15.30 9.44 3 285988 7797 90334659
Pneumocystis jirovecii pneumonia 15.28 9.44 28 285963 21588 90320868
Gangrene 15.26 9.44 11 285980 12865 90329591
Ecchymosis 15.18 9.44 78 285913 12245 90330211
Labelled drug-food interaction medication error 15.15 9.44 10 285981 270 90342186
Soliloquy 15.14 9.44 11 285980 348 90342108
Death of relative 15.08 9.44 12 285979 436 90342020
Transient ischaemic attack 15.01 9.44 205 285786 42971 90299485
Decreased immune responsiveness 14.97 9.44 61 285930 8687 90333769
Maximal voluntary ventilation abnormal 14.93 9.44 5 285986 25 90342431
Performance status decreased 14.82 9.44 38 285953 4242 90338214
Blood urea increased 14.80 9.44 154 285837 30259 90312197
Respiratory disorder 14.74 9.44 132 285859 64684 90277772
Persistent depressive disorder 14.73 9.44 19 285972 1238 90341218
Myositis 14.73 9.44 34 285957 24094 90318362
Tinnitus 14.72 9.44 204 285787 42898 90299558
Akathisia 14.71 9.44 72 285919 11087 90331369
Cytomegalovirus viraemia 14.71 9.44 3 285988 7583 90334873
Oesophageal food impaction 14.70 9.44 10 285981 284 90342172
Nasal polyps 14.68 9.44 8 285983 10872 90331584
Distributive shock 14.65 9.44 33 285958 3391 90339065
Oesophageal achalasia 14.62 9.44 14 285977 654 90341802
Congenital gastric anomaly 14.61 9.44 5 285986 27 90342429
Bone density decreased 14.60 9.44 20 285971 17325 90325131
Hiatus hernia 14.59 9.44 133 285858 25228 90317228
Blood alcohol increased 14.53 9.44 13 285978 556 90341900
Brugada syndrome 14.46 9.44 12 285979 463 90341993
Cerebral microangiopathy 14.37 9.44 10 285981 295 90342161
Hypotonia neonatal 14.29 9.44 20 285971 1410 90341046
Perineal pain 14.26 9.44 13 285978 570 90341886
Brain death 14.23 9.44 36 285955 3985 90338471
Body temperature decreased 14.19 9.44 34 285957 23782 90318674
Prothrombin level decreased 14.16 9.44 14 285977 680 90341776
Neurotoxicity 14.14 9.44 29 285962 21438 90321018
Cardiac hypertrophy 14.11 9.44 18 285973 1160 90341296
Divorced 14.07 9.44 4 285987 10 90342446
Polydipsia 14.07 9.44 37 285954 4194 90338262
Blood pressure diastolic increased 14.06 9.44 12 285979 12894 90329562
Body temperature increased 14.06 9.44 83 285908 44627 90297829
Suspiciousness 14.05 9.44 11 285980 390 90342066
Faecal vomiting 14.04 9.44 15 285976 799 90341657
Sensory disturbance 14.03 9.44 90 285901 15323 90327133
Thermal burns of eye 13.98 9.44 8 285983 166 90342290
Blood pressure systolic abnormal 13.98 9.44 25 285966 19453 90323003
Craniosynostosis 13.94 9.44 8 285983 167 90342289
Ventricular tachycardia 13.93 9.44 129 285862 24579 90317877
Tumour lysis syndrome 13.92 9.44 9 285982 11143 90331313
Alkalosis hypochloraemic 13.90 9.44 9 285982 235 90342221
Drug screen false positive 13.89 9.44 16 285975 927 90341529
Affective disorder 13.86 9.44 55 285936 7738 90334718
Hallucination, olfactory 13.83 9.44 10 285981 314 90342142
Electroencephalogram abnormal 13.80 9.44 36 285955 4060 90338396
Affect lability 13.78 9.44 101 285890 17962 90324494
Anterograde amnesia 13.77 9.44 13 285978 596 90341860
Cutaneous lymphoma 13.77 9.44 8 285983 171 90342285
Skin abrasion 13.76 9.44 71 285920 11164 90331292
Self-medication 13.74 9.44 31 285960 3189 90339267
Urinary incontinence 13.73 9.44 180 285811 37386 90305070
Hypoxic-ischaemic encephalopathy 13.70 9.44 39 285952 4629 90337827
Cardio-respiratory distress 13.69 9.44 8 285983 173 90342283
Product counterfeit 13.69 9.44 8 285983 173 90342283
Gastric polyps 13.68 9.44 39 285952 4633 90337823
Purpura senile 13.67 9.44 13 285978 602 90341854
Streptococcal sepsis 13.65 9.44 33 285958 3551 90338905
Phaeochromocytoma 13.63 9.44 13 285978 604 90341852
Eye injury 13.61 9.44 9 285982 11011 90331445
Gastritis 13.61 9.44 196 285795 41557 90300899
Metastases to liver 13.57 9.44 46 285945 28761 90313695
Haematochezia 13.55 9.44 306 285685 70607 90271849
Drowning 13.54 9.44 12 285979 507 90341949
Blood glucose increased 13.50 9.44 395 285596 94851 90247605
Pancytopenia 13.48 9.44 283 285708 119980 90222476
Frustration tolerance decreased 13.47 9.44 55 285936 7841 90334615
Hyporeflexia 13.44 9.44 25 285966 2241 90340215
Gastric infection 13.43 9.44 35 285956 3945 90338511
Hepatic cytolysis 13.41 9.44 153 285838 30763 90311693
Wrong patient 13.40 9.44 15 285976 842 90341614
Electrocardiogram repolarisation abnormality 13.39 9.44 19 285972 1357 90341099
Dysphagia 13.39 9.44 456 285535 111822 90230634
Rectal haemorrhage 13.38 9.44 349 285642 82395 90260061
Choking 13.35 9.44 74 285917 11959 90330497
Psychiatric symptom 13.28 9.44 51 285940 7067 90335389
Severe acute respiratory syndrome 13.28 9.44 5 285986 37 90342419
Flank pain 13.28 9.44 105 285886 19117 90323339
Feeling hot 13.24 9.44 170 285821 77838 90264618
Tooth loss 13.19 9.44 53 285938 7501 90334955
Venous oxygen saturation increased 13.17 9.44 5 285986 38 90342418
Decreased interest 13.11 9.44 37 285954 4370 90338086
Atrioventricular septal defect 13.11 9.44 10 285981 341 90342115
Lactic acidosis 13.08 9.44 228 285763 50235 90292221
Heart rate increased 13.08 9.44 457 285534 112445 90230011
Libido decreased 13.05 9.44 29 285962 2953 90339503
Tachyphrenia 12.97 9.44 21 285970 1685 90340771
Dermatitis atopic 12.95 9.44 122 285869 23350 90319106
Mental disability 12.91 9.44 8 285983 193 90342263
Retrograde amnesia 12.86 9.44 12 285979 542 90341914
Coagulation factor V level decreased 12.84 9.44 10 285981 352 90342104
Haemangioma congenital 12.83 9.44 12 285979 544 90341912
Nervous system disorder 12.81 9.44 114 285877 21479 90320977
Tobacco user 12.71 9.44 14 285977 772 90341684
Congenital limb hyperextension 12.66 9.44 4 285987 16 90342440
Hair texture abnormal 12.65 9.44 38 285953 4649 90337807
Sinus arrhythmia 12.64 9.44 19 285972 1430 90341026
Perseveration 12.63 9.44 9 285982 276 90342180
Dental caries 12.58 9.44 70 285921 11327 90331129
Foreign body in reproductive tract 12.57 9.44 17 285974 1160 90341296
Ear pruritus 12.57 9.44 3 285988 6800 90335656
Hypertension 12.57 9.44 1258 284733 456274 89886182
Weight decreased 12.54 9.44 1376 284615 378534 89963922
Central nervous system lesion 12.51 9.44 71 285920 11575 90330881
Physical examination abnormal 12.51 9.44 7 285984 139 90342317
Anion gap abnormal 12.50 9.44 10 285981 366 90342090
Rash erythematous 12.46 9.44 281 285710 64823 90277633
Congenital central nervous system anomaly 12.44 9.44 11 285980 463 90341993
Brachial artery entrapment syndrome 12.44 9.44 5 285986 45 90342411
Borderline personality disorder 12.44 9.44 16 285975 1040 90341416
Disturbance in sexual arousal 12.43 9.44 9 285982 283 90342173
Respiratory distress 12.37 9.44 182 285809 38764 90303692
Necrotising colitis 12.32 9.44 18 285973 1320 90341136
Cholinergic syndrome 12.31 9.44 13 285978 683 90341773
Septic shock 12.30 9.44 189 285802 83971 90258485
Economic problem 12.27 9.44 30 285961 3251 90339205
Cushingoid 12.16 9.44 9 285982 10386 90332070
Myocardial infarction 12.04 9.44 428 285563 105544 90236912
Product administration interrupted 12.03 9.44 74 285917 12418 90330038
Accidental poisoning 12.03 9.44 15 285976 945 90341511
Product taste abnormal 12.00 9.44 25 285966 2435 90340021
Fatigue 11.99 9.44 3352 282639 1150671 89191785
Tardive dyskinesia 11.98 9.44 67 285924 10863 90331593
Skin warm 11.91 9.44 52 285939 7635 90334821
Sepsis syndrome 11.86 9.44 15 285976 958 90341498
Metastases to bone 11.83 9.44 41 285950 25464 90316992
Burn oesophageal 11.81 9.44 10 285981 397 90342059
Intervertebral disc disorder 11.78 9.44 41 285950 5419 90337037
Foreign body 11.77 9.44 25 285966 2469 90339987
Meningioma 11.75 9.44 39 285952 5032 90337424
Head discomfort 11.71 9.44 90 285901 16243 90326213
Neonatal behavioural syndrome 11.71 9.44 6 285985 99 90342357
Acute coronary syndrome 11.67 9.44 66 285925 10747 90331709
Hepatitis fulminant 11.62 9.44 33 285958 3912 90338544
Essential tremor 11.59 9.44 18 285973 1394 90341062
Dyspepsia 11.58 9.44 509 285482 197651 90144805
Stress cardiomyopathy 11.56 9.44 77 285914 13278 90329178
Prothrombin level increased 11.55 9.44 9 285982 317 90342139
Poor venous access 11.54 9.44 28 285963 19499 90322957
Maternal exposure before pregnancy 11.53 9.44 11 285980 11202 90331254
Crime 11.48 9.44 4 285987 23 90342433
Full blood count abnormal 11.48 9.44 68 285923 36529 90305927
Hyperaldosteronism 11.45 9.44 9 285982 321 90342135
Listless 11.41 9.44 29 285962 3220 90339236
Exposure via inhalation 11.40 9.44 5 285986 57 90342399
Quadriparesis 11.39 9.44 25 285966 2524 90339932
Appetite disorder 11.39 9.44 58 285933 9075 90333381
Vasoconstriction 11.36 9.44 14 285977 871 90341585
Tearfulness 11.28 9.44 37 285954 4743 90337713
Mixed anxiety and depressive disorder 11.27 9.44 10 285981 423 90342033
Libido disorder 11.25 9.44 5 285986 59 90342397
Nephrosclerosis 11.17 9.44 16 285975 1153 90341303
Tenosynovitis 11.09 9.44 18 285973 14549 90327907
Influenza like illness 11.07 9.44 333 285658 80278 90262178
Hyperprolactinaemia 11.03 9.44 40 285951 5393 90337063
Hyperinsulinism 11.01 9.44 3 285988 6 90342450
Ligneous conjunctivitis 11.01 9.44 3 285988 6 90342450
Cardioplegia 11.01 9.44 3 285988 6 90342450
Carotid pulse abnormal 11.01 9.44 3 285988 6 90342450
Catatonia 10.98 9.44 43 285948 6013 90336443
Depersonalisation/derealisation disorder 10.95 9.44 19 285972 1613 90340843
Extrasystoles 10.94 9.44 41 285950 5616 90336840
Product colour issue 10.94 9.44 13 285978 779 90341677
Vitamin D decreased 10.93 9.44 70 285921 11909 90330547
Eating disorder 10.89 9.44 136 285855 27937 90314519
Alcohol withdrawal syndrome 10.88 9.44 14 285977 910 90341546
Uterine perforation 10.88 9.44 50 285941 7504 90334952
Product dose omission issue 10.83 9.44 1065 284926 290622 90051834
Mental impairment 10.83 9.44 90 285901 16630 90325826
Pupil fixed 10.82 9.44 22 285969 2106 90340350
Acute lung injury 10.79 9.44 18 285973 1480 90340976
Pseudomonal sepsis 10.79 9.44 34 285957 4268 90338188
Cerebrovascular accident 10.79 9.44 485 285506 123048 90219408
Cardiomegaly 10.76 9.44 99 285892 18826 90323630
Metabolic encephalopathy 10.71 9.44 46 285945 6706 90335750
Throat irritation 10.71 9.44 100 285891 48595 90293861
Incorrect route of product administration 10.70 9.44 105 285886 50521 90291935
Hypercapnic coma 10.69 9.44 8 285983 265 90342191
Lacunar infarction 10.69 9.44 29 285962 3348 90339108
Hospitalisation 10.68 9.44 315 285676 127785 90214671
Mixed liver injury 10.64 9.44 50 285941 7573 90334883
Prurigo 10.63 9.44 14 285977 931 90341525
Rash maculo-papular 10.63 9.44 185 285806 40748 90301708
Drop attacks 10.60 9.44 12 285979 682 90341774
Unevaluable event 10.58 9.44 237 285754 54611 90287845
Drug dose omission by device 10.57 9.44 10 285981 10221 90332235
Regurgitation 10.55 9.44 22 285969 2144 90340312
Herpes zoster 10.53 9.44 223 285768 94421 90248035
Abnormal uterine bleeding 10.47 9.44 21 285970 1991 90340465
Beta haemolytic streptococcal infection 10.47 9.44 24 285967 2495 90339961
Fear of injection 10.46 9.44 7 285984 8508 90333948
Coronary artery occlusion 10.44 9.44 54 285937 8500 90333956
Sickle cell anaemia with crisis 10.39 9.44 5 285986 7292 90335164
Myoglobin blood increased 10.33 9.44 18 285973 1534 90340922
Temporomandibular joint syndrome 10.31 9.44 32 285959 3985 90338471
Fluid retention 10.31 9.44 357 285634 87734 90254722
Flat affect 10.31 9.44 19 285972 1692 90340764
Paraesthesia 10.30 9.44 666 285325 249660 90092796
Product dosage form issue 10.25 9.44 4 285987 33 90342423
Hepatitis acute 10.17 9.44 64 285927 10823 90331633
Hepatotoxicity 10.14 9.44 94 285897 45748 90296708
Dermatitis allergic 10.12 9.44 25 285966 17302 90325154
Chronic fatigue syndrome 10.10 9.44 18 285973 1561 90340895
Blood potassium decreased 10.09 9.44 209 285782 47518 90294938
Angina unstable 10.08 9.44 47 285944 7096 90335360
Laboratory test abnormal 10.07 9.44 84 285907 41770 90300686
Embolic stroke 10.05 9.44 32 285959 4040 90338416
Leukoencephalopathy 10 9.44 36 285955 4837 90337619
Postoperative delirium 9.99 9.44 7 285984 209 90342247
Blood chloride decreased 9.99 9.44 43 285948 6276 90336180
Feelings of worthlessness 9.98 9.44 9 285982 389 90342067
Cerebral disorder 9.98 9.44 40 285951 5654 90336802
Face oedema 9.94 9.44 115 285876 23203 90319253
Hot flush 9.94 9.44 252 285739 59236 90283220
Amnesia 9.92 9.44 428 285563 108077 90234379
Cerebellar cognitive affective syndrome 9.92 9.44 3 285988 10 90342446
Toxic epidermal necrolysis 9.90 9.44 61 285930 32467 90309989
Normochromic normocytic anaemia 9.89 9.44 37 285954 5065 90337391
Enanthema 9.88 9.44 10 285981 500 90341956
Micturition urgency 9.86 9.44 65 285926 11168 90331288
Confusional arousal 9.81 9.44 8 285983 301 90342155
Chills 9.81 9.44 510 285481 131471 90210985
Carotid artery stenosis 9.78 9.44 38 285953 5296 90337160
Visual acuity reduced 9.77 9.44 115 285876 23295 90319161
Myxoedema coma 9.71 9.44 9 285982 403 90342053
Placental infarction 9.70 9.44 8 285983 306 90342150
Strabismus 9.70 9.44 23 285968 2445 90340011
Respiratory tract congestion 9.65 9.44 49 285942 27361 90315095
Frostbite 9.65 9.44 7 285984 221 90342235
Altered visual depth perception 9.64 9.44 9 285982 407 90342049
Pollakiuria 9.62 9.44 152 285839 32853 90309603
Joint effusion 9.61 9.44 31 285960 19679 90322777
Compulsive shopping 9.61 9.44 12 285979 757 90341699
Glossitis 9.60 9.44 29 285962 3558 90338898
Accidental exposure to product by child 9.58 9.44 16 285975 1317 90341139
Moaning 9.56 9.44 14 285977 1029 90341427
Mitral valve incompetence 9.56 9.44 111 285880 22413 90320043
Inflammatory marker increased 9.52 9.44 9 285982 9205 90333251
Blood test abnormal 9.51 9.44 34 285957 20918 90321538
Pseudohyperkalaemia 9.50 9.44 3 285988 12 90342444
Protein C decreased 9.50 9.44 4 285987 41 90342415
Memory impairment 9.47 9.44 734 285257 196510 90145946
Vascular pseudoaneurysm ruptured 9.47 9.44 5 285986 88 90342368
Varicose vein 9.46 9.44 47 285944 7280 90335176
Laryngomalacia 9.46 9.44 6 285985 151 90342305

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug abuse 9140.40 10.90 4983 124160 99788 42392404
Toxicity to various agents 2970.89 10.90 3551 125592 225585 42266607
Completed suicide 2709.17 10.90 2279 126864 94186 42398006
Respiratory arrest 1970.56 10.90 1169 127974 27255 42464937
Poisoning 1511.22 10.90 784 128359 13915 42478277
Cardio-respiratory arrest 1264.35 10.90 1195 127948 57441 42434751
Drug dependence 1054.53 10.90 800 128343 28294 42463898
Cardiac arrest 894.80 10.90 1359 127784 107961 42384231
Sopor 859.78 10.90 522 128621 12680 42479512
Intentional product misuse 853.73 10.90 994 128149 60906 42431286
Suicide attempt 846.62 10.90 861 128282 45239 42446953
Coma 818.27 10.90 907 128236 52647 42439545
Intentional overdose 776.71 10.90 866 128277 50590 42441602
Overdose 690.82 10.90 1184 127959 104080 42388112
Poisoning deliberate 604.63 10.90 379 128764 9755 42482437
Drug use disorder 529.03 10.90 351 128792 9982 42482210
Withdrawal syndrome 370.30 10.90 328 128815 14447 42477745
Off label use 369.50 10.90 875 128268 637460 41854732
Drug withdrawal syndrome 339.20 10.90 371 128772 21178 42471014
Intentional self-injury 300.97 10.90 296 128847 14906 42477286
Somnolence 286.24 10.90 1009 128134 140096 42352096
Exposure via ingestion 285.53 10.90 136 129007 1986 42490206
Substance abuse 248.02 10.90 210 128933 8695 42483497
Miosis 244.47 10.90 250 128893 13196 42478996
Prescription form tampering 238.20 10.90 84 129059 528 42491664
Drug ineffective 220.20 10.90 1074 128069 629123 41863069
Suicidal ideation 216.75 10.90 462 128681 47699 42444493
Febrile neutropenia 195.88 10.90 165 128978 185538 42306654
Accidental overdose 188.44 10.90 321 128822 28009 42464183
Depressed level of consciousness 187.52 10.90 435 128708 47535 42444657
Respiratory depression 176.17 10.90 250 128893 18618 42473574
Drug abuser 176.01 10.90 118 129025 3413 42488779
Agitation 173.99 10.90 508 128635 63806 42428386
Substance use disorder 165.41 10.90 134 129009 5211 42486981
Anxiety 164.12 10.90 753 128390 117807 42374385
Death 148.13 10.90 2121 127022 469064 42023128
Bradypnoea 146.33 10.90 115 129028 4278 42487914
Depression 137.92 10.90 685 128458 110678 42381514
Pyrexia 136.77 10.90 672 128471 393370 42098822
Drug screen positive 124.53 10.90 102 129041 4029 42488163
COVID-19 117.35 10.90 107 129036 115841 42376351
Insomnia 113.10 10.90 678 128465 117575 42374617
Aggression 112.90 10.90 342 128801 43821 42448371
Bradyphrenia 107.01 10.90 104 129039 5158 42487034
Pneumonia 97.61 10.90 815 128328 421334 42070858
Asphyxia 97.13 10.90 123 129020 8203 42483989
Accidental death 96.90 10.90 78 129065 3005 42489187
Treatment failure 95.68 10.90 35 129108 62589 42429603
Alcohol interaction 93.78 10.90 66 129077 2069 42490123
Sepsis 93.71 10.90 301 128842 199033 42293159
Myelosuppression 90.14 10.90 9 129134 40452 42451740
Loss of consciousness 89.22 10.90 531 128612 91823 42400369
Unresponsive to stimuli 88.69 10.90 252 128891 31151 42461041
Panic attack 85.40 10.90 134 129009 10911 42481281
Neutropenia 83.09 10.90 317 128826 199114 42293078
Altered state of consciousness 81.85 10.90 234 128909 29025 42463167
Amnesia 81.08 10.90 229 128914 28208 42463984
Self-medication 80.80 10.90 72 129071 3194 42488998
Renal impairment 79.61 10.90 132 129011 110096 42382096
Abnormal behaviour 79.36 10.90 217 128926 26234 42465958
Disease progression 79.18 10.90 201 128942 143455 42348737
Counterfeit product administered 76.40 10.90 30 129113 264 42491928
Product use in unapproved indication 76.31 10.90 294 128849 184162 42308030
Disturbance in attention 75.11 10.90 230 128913 29636 42462556
Condition aggravated 73.27 10.90 476 128667 260278 42231914
Pulmonary oedema 72.60 10.90 337 128806 52935 42439257
Infection 71.33 10.90 145 128998 111923 42380269
Accidental poisoning 71.13 10.90 46 129097 1250 42490942
Cough 69.79 10.90 290 128853 177813 42314379
Anaemia 69.29 10.90 531 128612 279747 42212445
Psychomotor hyperactivity 68.70 10.90 121 129022 10837 42481355
C-reactive protein increased 67.49 10.90 56 129087 63504 42428688
Rash 67.38 10.90 527 128616 276427 42215765
Dissociation 66.10 10.90 69 129074 3729 42488463
Cytomegalovirus infection 65.11 10.90 10 129133 32296 42459896
Alcohol abuse 64.18 10.90 70 129073 3979 42488213
Drug tolerance 63.13 10.90 63 129080 3227 42488965
Irritability 61.98 10.90 207 128936 27921 42464271
Mydriasis 61.79 10.90 102 129041 8668 42483524
Product counterfeit 61.76 10.90 22 129121 143 42492049
Infusion related reaction 61.62 10.90 56 129087 60750 42431442
Platelet count decreased 61.15 10.90 215 128928 138366 42353826
Mucosal inflammation 60.96 10.90 37 129106 49337 42442855
Inappropriate schedule of product administration 59.40 10.90 126 129017 95776 42396416
Therapeutic product effect incomplete 58.97 10.90 77 129066 70862 42421330
Diarrhoea 58.49 10.90 1014 128129 459835 42032357
Drug detoxification 58.47 10.90 27 129116 366 42491826
Toxicologic test abnormal 58.12 10.90 29 129114 471 42491721
Drug resistance 57.89 10.90 16 129127 34232 42457960
Hallucination, visual 57.71 10.90 167 128976 20853 42471339
Cytokine release syndrome 56.91 10.90 32 129111 44495 42447697
Lower respiratory tract infection 55.03 10.90 28 129115 41178 42451014
Confusional state 52.48 10.90 755 128388 166842 42325350
Suspected suicide 50.43 10.90 77 129066 6122 42486070
Drug intolerance 50.36 10.90 105 129038 80319 42411873
Postmortem blood drug level abnormal 49.80 10.90 24 129119 360 42491832
Sudden death 49.45 10.90 136 129007 16493 42475699
Pulmonary congestion 49.14 10.90 131 129012 15599 42476593
Disorientation 48.69 10.90 229 128914 36160 42456032
Hepatic function abnormal 48.19 10.90 51 129092 51516 42440676
Brain oedema 48.03 10.90 133 129010 16194 42475998
Neutrophil count decreased 47.59 10.90 74 129069 63341 42428851
Road traffic accident 47.04 10.90 146 128997 18947 42473245
Arthralgia 46.90 10.90 397 128746 204841 42287351
General physical health deterioration 46.64 10.90 268 128875 150978 42341214
Prescription drug used without a prescription 46.45 10.90 49 129094 2681 42489511
Dyspnoea 45.74 10.90 1008 128135 441613 42050579
Dysarthria 45.11 10.90 239 128904 39568 42452624
Nervousness 44.62 10.90 115 129028 13417 42478775
Drug diversion 44.49 10.90 31 129112 956 42491236
Anger 44.35 10.90 112 129031 12906 42479286
Thinking abnormal 43.51 10.90 78 129065 7083 42485109
Tremor 42.94 10.90 466 128677 96463 42395729
White blood cell count decreased 42.43 10.90 181 128962 110215 42381977
Joint swelling 42.42 10.90 89 129054 67933 42424259
Dissociative disorder 42.26 10.90 26 129117 646 42491546
Narcotic bowel syndrome 41.96 10.90 16 129127 129 42492063
Drug withdrawal syndrome neonatal 41.47 10.90 59 129084 4402 42487790
Alcohol use 41.30 10.90 47 129096 2801 42489391
Obstructive airways disorder 41.04 10.90 12 129131 24747 42467445
Malignant neoplasm progression 40.89 10.90 179 128964 108221 42383971
Cardiac failure 40.58 10.90 176 128967 106680 42385512
Anorgasmia 40.56 10.90 31 129112 1106 42491086
Serotonin syndrome 40.11 10.90 170 128973 25675 42466517
Ascites 39.86 10.90 69 129074 56609 42435583
Pruritus 39.24 10.90 374 128769 188397 42303795
Acute kidney injury 38.93 10.90 833 128310 366504 42125688
Pancytopenia 38.83 10.90 204 128939 117539 42374653
Foreign body aspiration 38.39 10.90 19 129124 303 42491889
Drug interaction 37.89 10.90 1068 128075 265931 42226261
Dependence 37.35 10.90 33 129110 1447 42490745
Wheezing 36.46 10.90 69 129074 54712 42437480
Haematochezia 35.98 10.90 77 129066 58359 42433833
Manic symptom 35.87 10.90 16 129127 199 42491993
Interstitial lung disease 35.75 10.90 120 129023 78342 42413850
Bladder dilatation 35.49 10.90 34 129109 1656 42490536
Respiratory failure 35.35 10.90 235 128908 127897 42364295
Substance dependence 35.11 10.90 23 129120 639 42491553
Homicide 34.97 10.90 26 129117 889 42491303
Non-cardiogenic pulmonary oedema 34.47 10.90 26 129117 909 42491283
Andropause 34.40 10.90 13 129130 102 42492090
Rheumatoid arthritis 34.31 10.90 47 129096 42393 42449799
Abulia 34.25 10.90 23 129120 667 42491525
Bradykinesia 34.04 10.90 60 129083 5376 42486816
Hospitalisation 33.65 10.90 114 129029 74216 42417976
Full blood count abnormal 33.37 10.90 25 129118 29851 42462341
Sedation 33.19 10.90 181 128962 30294 42461898
Feeling abnormal 33.00 10.90 340 128803 69446 42422746
Pneumonia aspiration 32.34 10.90 261 128882 49817 42442375
Drug withdrawal convulsions 32.12 10.90 29 129114 1309 42490883
Substance abuser 31.90 10.90 16 129127 263 42491929
Catatonia 31.75 10.90 63 129080 6176 42486016
Blood creatinine increased 31.74 10.90 199 128944 109804 42382388
Exposure during pregnancy 31.72 10.90 76 129067 8472 42483720
Haemoglobin decreased 31.70 10.90 253 128890 132218 42359974
Panic disorder 31.29 10.90 28 129115 1249 42490943
Hyperthermia 30.83 10.90 96 129047 12478 42479714
Blood pressure fluctuation 30.73 10.90 22 129121 26886 42465306
Paramnesia 30.37 10.90 8 129135 14 42492178
Ventricular fibrillation 30.20 10.90 28 129115 30095 42462097
Asthma 29.99 10.90 93 129050 62221 42429971
Hypophosphataemia 29.86 10.90 13 129130 20932 42471260
Neutropenic sepsis 29.81 10.90 6 129137 15940 42476252
Erythema 29.77 10.90 200 128943 108593 42383599
Angioedema 29.60 10.90 52 129091 42425 42449767
Pneumocystis jirovecii pneumonia 29.53 10.90 20 129123 25161 42467031
Aspergillus infection 29.52 10.90 6 129137 15831 42476361
Bone marrow failure 29.52 10.90 34 129109 33059 42459133
Victim of chemical submission 29.48 10.90 13 129130 157 42492035
Bronchopulmonary aspergillosis 29.43 10.90 11 129132 19418 42472774
Multiple organ dysfunction syndrome 29.32 10.90 173 128970 96862 42395330
Anaphylactic reaction 29.18 10.90 53 129090 42690 42449502
Drug ineffective for unapproved indication 29.12 10.90 60 129083 46103 42446089
Bacterial infection 29.05 10.90 25 129118 27854 42464338
Puncture site haematoma 28.70 10.90 13 129130 168 42492024
Blood pressure systolic increased 28.04 10.90 26 129117 27942 42464250
Chemical poisoning 27.99 10.90 11 129132 97 42492095
Gun shot wound 27.94 10.90 24 129119 1013 42491179
Electrocardiogram QT prolonged 27.84 10.90 244 128899 47701 42444491
Hypervolaemia 27.62 10.90 18 129125 23107 42469085
Hallucination 27.58 10.90 281 128862 57226 42434966
Appendicitis 27.53 10.90 14 129129 20599 42471593
Hypothermia 27.47 10.90 92 129051 12423 42479769
Prostate cancer 27.34 10.90 59 129084 44584 42447608
Substance use 27.28 10.90 30 129113 1721 42490471
Bacteraemia 26.65 10.90 22 129121 25018 42467174
Analgesic drug level increased 26.57 10.90 24 129119 1084 42491108
Speech disorder 26.54 10.90 165 128978 28956 42463236
Stomatitis 26.49 10.90 72 129071 50257 42441935
Loss of personal independence in daily activities 26.42 10.90 71 129072 49745 42442447
Heart rate decreased 26.12 10.90 44 129099 36488 42455704
Gastrointestinal haemorrhage 26.07 10.90 181 128962 97545 42394647
Respiratory rate decreased 25.99 10.90 38 129105 2907 42489285
Generalised anxiety disorder 25.95 10.90 22 129121 912 42491280
Atrial fibrillation 25.52 10.90 285 128858 139308 42352884
Renal failure 25.28 10.90 296 128847 143430 42348762
Nasopharyngitis 25.25 10.90 150 128993 83846 42408346
Poverty of speech 25.16 10.90 13 129130 228 42491964
Pleural effusion 24.93 10.90 182 128961 96984 42395208
Drug tolerance increased 24.70 10.90 16 129127 436 42491756
Malignant catatonia 24.48 10.90 16 129127 443 42491749
Pathogen resistance 24.35 10.90 3 129140 11447 42480745
Deafness neurosensory 24.31 10.90 42 129101 3704 42488488
Brain injury 24.16 10.90 64 129079 7591 42484601
Psoriatic arthropathy 24.11 10.90 24 129119 24943 42467249
Marchiafava-Bignami disease 24.01 10.90 5 129138 0 42492192
Hypervigilance 23.89 10.90 11 129132 148 42492044
Hyperleukocytosis 23.52 10.90 34 129109 2574 42489618
Respiratory symptom 23.40 10.90 3 129140 11103 42481089
Major depression 23.36 10.90 51 129092 5347 42486845
Thrombocytopenia 23.27 10.90 421 128722 189858 42302334
Psychomotor retardation 23.09 10.90 45 129098 4354 42487838
Delirium 23.01 10.90 252 128891 52267 42439925
Yawning 22.92 10.90 19 129124 763 42491429
Leukopenia 22.72 10.90 133 129010 74613 42417579
Blood catecholamines increased 22.63 10.90 7 129136 27 42492165
Gas poisoning 22.36 10.90 9 129134 85 42492107
Urticaria 22.36 10.90 132 129011 73904 42418288
Inadequate analgesia 22.28 10.90 37 129106 3160 42489032
Diabetic ketoacidosis 22.18 10.90 21 129122 22346 42469846
Withdrawal catatonia 22.14 10.90 12 129131 233 42491959
Inappropriate antidiuretic hormone secretion 22.05 10.90 104 129039 16437 42475755
Injection site pain 22.05 10.90 95 129048 57703 42434489
Disease recurrence 21.91 10.90 35 129108 29643 42462549
Legal problem 21.82 10.90 10 129133 133 42492059
Synovitis 21.66 10.90 10 129133 15557 42476635
Vestibular ischaemia 21.63 10.90 6 129137 14 42492178
Alanine aminotransferase increased 21.53 10.90 168 128975 88238 42403954
Pulmonary alveolar haemorrhage 21.43 10.90 9 129134 14807 42477385
Oedema peripheral 21.39 10.90 287 128856 135789 42356403
Feeling jittery 21.20 10.90 44 129099 4454 42487738
Pulmonary fibrosis 21.11 10.90 30 129113 26651 42465541
Memory impairment 21.10 10.90 239 128904 49983 42442209
Cerebral haemorrhage 21.07 10.90 55 129088 38911 42453281
Victim of homicide 20.89 10.90 11 129132 201 42491991
Therapy partial responder 20.80 10.90 18 129125 20003 42472189
COVID-19 pneumonia 20.61 10.90 21 129122 21592 42470600
Myotonia 20.41 10.90 7 129136 40 42492152
Therapy non-responder 20.17 10.90 88 129055 53271 42438921
Septic shock 20.15 10.90 179 128964 91493 42400699
Clinomania 20.12 10.90 7 129136 42 42492150
Cerebral infarction 20.09 10.90 40 129103 31129 42461063
Faecal disimpaction 20.08 10.90 6 129137 20 42492172
Blood test abnormal 20.07 10.90 7 129136 12899 42479293
Abdominal distension 20.06 10.90 131 129012 71604 42420588
Respiratory acidosis 20.05 10.90 53 129090 6278 42485914
Myasthenia gravis 20.04 10.90 12 129131 16125 42476067
Product dose omission issue 20.00 10.90 338 128805 154027 42338165
Tubulointerstitial nephritis 19.90 10.90 41 129102 31507 42460685
Visceral congestion 19.89 10.90 19 129124 922 42491270
Clostridium difficile colitis 19.87 10.90 21 129122 21231 42470961
Hypersensitivity 19.81 10.90 133 129010 72237 42419955
Victim of crime 19.75 10.90 15 129128 530 42491662
Thrombosis 19.72 10.90 124 129019 68387 42423805
Herpes zoster 19.44 10.90 57 129086 38820 42453372
Papillary muscle disorder 19.21 10.90 4 129139 0 42492192
Frequent bowel movements 19.08 10.90 22 129121 21385 42470807
Bronchiectasis 18.97 10.90 16 129127 18003 42474189
Growth hormone deficiency 18.89 10.90 12 129131 316 42491876
Colitis microscopic 18.87 10.90 34 129109 3099 42489093
Pneumonitis 18.86 10.90 64 129079 41654 42450538
Injury 18.83 10.90 124 129019 22192 42470000
Lip swelling 18.76 10.90 18 129125 19035 42473157
Oesophagitis chemical 18.74 10.90 7 129136 53 42492139
Acute myeloid leukaemia 18.65 10.90 24 129119 22232 42469960
Blood triglycerides abnormal 18.59 10.90 11 129132 254 42491938
Foaming at mouth 18.54 10.90 19 129124 1005 42491187
Stevens-Johnson syndrome 18.50 10.90 24 129119 22154 42470038
Liver disorder 18.49 10.90 60 129083 39584 42452608
Productive cough 18.33 10.90 87 129056 51480 42440712
Hostility 18.30 10.90 17 129126 796 42491396
Hyperhidrosis 18.22 10.90 380 128763 90132 42402060
Arthropathy 18.22 10.90 39 129104 29558 42462634
Negativism 18.18 10.90 13 129130 418 42491774
Chorea 17.91 10.90 22 129121 1422 42490770
Foetal exposure during pregnancy 17.90 10.90 78 129065 47233 42444959
Hypokinesia 17.77 10.90 68 129075 9803 42482389
Sleep disorder due to a general medical condition 17.76 10.90 16 129127 17437 42474755
Brain hypoxia 17.69 10.90 15 129128 622 42491570
Swollen tongue 17.68 10.90 23 129120 21208 42470984
Physical assault 17.66 10.90 19 129124 1063 42491129
Nephropathy toxic 17.66 10.90 15 129128 16823 42475369
Influenza 17.66 10.90 113 129030 62062 42430130
Mania 17.64 10.90 71 129072 10476 42481716
Distributive shock 17.54 10.90 29 129114 2467 42489725
Cytomegalovirus infection reactivation 17.49 10.90 6 129137 11172 42481020
Lymphadenopathy 17.35 10.90 48 129095 33317 42458875
Oedematous pancreatitis 17.30 10.90 16 129127 745 42491447
Haemorrhage 17.23 10.90 110 129033 60453 42431739
Personality change 17.23 10.90 47 129096 5672 42486520
Aplastic anaemia 17.16 10.90 8 129135 12376 42479816
Hyperphosphataemia 17.12 10.90 9 129134 12995 42479197
Lactic acidosis 16.89 10.90 75 129068 45186 42447006
Sexual dysfunction 16.86 10.90 52 129091 6723 42485469
Polyneuropathy 16.83 10.90 19 129124 18642 42473550
Painful ejaculation 16.82 10.90 9 129134 170 42492022
Tachycardia 16.79 10.90 413 128730 100674 42391518
Bezoar 16.74 10.90 20 129123 1256 42490936
Administration related reaction 16.73 10.90 9 129134 172 42492020
Hyporesponsive to stimuli 16.72 10.90 22 129121 1524 42490668
Peripheral swelling 16.61 10.90 184 128959 90086 42402106
Brachial plexus injury 16.54 10.90 7 129136 76 42492116
Euphoric mood 16.50 10.90 50 129093 6403 42485789
Squamous cell carcinoma of skin 16.47 10.90 9 129134 12717 42479475
Homicidal ideation 16.42 10.90 30 129113 2764 42489428
Gastrointestinal disorder 16.41 10.90 79 129064 46574 42445618
Neoplasm progression 16.40 10.90 40 129103 28960 42463232
Blood alcohol increased 16.40 10.90 14 129129 586 42491606
Cholangitis 16.37 10.90 6 129137 10721 42481471
Upper gastrointestinal haemorrhage 16.20 10.90 43 129100 30256 42461936
Low birth weight baby 16.18 10.90 5 129138 9950 42482242
Lethargy 16.17 10.90 215 128928 46675 42445517
Product substitution 16.11 10.90 6 129137 45 42492147
Mobility decreased 16.07 10.90 54 129089 35252 42456940
Hypothyroidism 16.07 10.90 47 129096 32037 42460155
Postprandial hypoglycaemia 16.07 10.90 7 129136 82 42492110
Blood phosphorus increased 16.00 10.90 9 129134 12516 42479676
Cellulitis 15.96 10.90 115 129028 61470 42430722
Therapeutic response decreased 15.92 10.90 58 129085 36954 42455238
Dizziness 15.91 10.90 606 128537 248648 42243544
Nystagmus 15.91 10.90 44 129099 5352 42486840
Contraindicated product administered 15.80 10.90 33 129110 25239 42466953
Bipolar disorder 15.79 10.90 36 129107 3886 42488306
Hepatic cytolysis 15.78 10.90 137 129006 26707 42465485
Transplant rejection 15.66 10.90 11 129132 13577 42478615
Hepatotoxicity 15.62 10.90 33 129110 25134 42467058
Extrapyramidal disorder 15.59 10.90 94 129049 16318 42475874
Neuropathy peripheral 15.58 10.90 216 128927 101637 42390555
Neurotoxicity 15.55 10.90 30 129113 23621 42468571
Oesophageal carcinoma 15.53 10.90 5 129138 9691 42482501
Hallucinations, mixed 15.49 10.90 33 129110 3402 42488790
Hypoventilation 15.42 10.90 35 129108 3767 42488425
Accident 15.35 10.90 49 129094 6454 42485738
Liver function test increased 15.32 10.90 23 129120 19975 42472217
Second primary malignancy 15.22 10.90 5 129138 9570 42482622
Leukoencephalopathy 15.21 10.90 41 129102 4913 42487279
Pain in extremity 15.17 10.90 344 128799 150260 42341932
Progressive multifocal leukoencephalopathy 15.16 10.90 8 129135 11528 42480664
Dyskinesia 15.14 10.90 130 129013 25260 42466932
Drug hypersensitivity 15.12 10.90 211 128932 99178 42393014
Substance-induced mood disorder 15.07 10.90 6 129137 55 42492137
Cardio-respiratory distress 15.06 10.90 8 129135 149 42492043
Tachyphylaxis 14.96 10.90 8 129135 151 42492041
Bacterial prostatitis 14.96 10.90 7 129136 98 42492094
Oropharyngeal pain 14.94 10.90 72 129071 42438 42449754
Arthritis 14.93 10.90 71 129072 41994 42450198
Sluggishness 14.85 10.90 35 129108 3861 42488331
Amimia 14.84 10.90 4 129139 8 42492184
Tachyphrenia 14.83 10.90 20 129123 1419 42490773
Basal cell carcinoma 14.80 10.90 29 129114 22704 42469488
Panic reaction 14.80 10.90 22 129121 1708 42490484
Tumour lysis syndrome 14.79 10.90 28 129115 22203 42469989
Osteoporosis 14.77 10.90 14 129129 14892 42477300
Prothrombin time shortened 14.75 10.90 21 129122 1568 42490624
Blood lactate dehydrogenase increased 14.73 10.90 36 129107 26045 42466147
Vestibular disorder 14.71 10.90 18 129125 1159 42491033
Pulmonary toxicity 14.71 10.90 4 129139 8651 42483541
Fear 14.66 10.90 69 129074 10896 42481296
Dysphemia 14.60 10.90 23 129120 1879 42490313
Incision site pain 14.59 10.90 23 129120 1880 42490312
Restlessness 14.54 10.90 144 128999 29105 42463087
Amnestic disorder 14.50 10.90 10 129133 303 42491889
Myoclonus 14.50 10.90 95 129048 16970 42475222
Cataract 14.49 10.90 46 129097 30558 42461634
Blood creatine phosphokinase 14.47 10.90 7 129136 106 42492086
Epistaxis 14.46 10.90 131 129012 66695 42425497
Anamnestic reaction 14.44 10.90 6 129137 62 42492130
Shoplifting 14.41 10.90 3 129140 0 42492192
Confirmed e-cigarette or vaping product use associated lung injury 14.41 10.90 3 129140 0 42492192
Acute myocardial infarction 14.41 10.90 110 129033 58055 42434137
Judgement impaired 14.34 10.90 13 129130 590 42491602
Theft 14.34 10.90 9 129134 232 42491960
Aspartate aminotransferase increased 14.30 10.90 157 128986 77006 42415186
Gastric haemorrhage 14.26 10.90 7 129136 10508 42481684
Slow speech 14.23 10.90 22 129121 1768 42490424
Nervous system disorder 14.17 10.90 95 129048 17100 42475092
Ventricular tachyarrhythmia 14.12 10.90 11 129132 404 42491788
Colitis ulcerative 14.11 10.90 37 129106 26138 42466054
Exposure via inhalation 14.10 10.90 5 129138 32 42492160
Oedema 14.01 10.90 96 129047 51905 42440287
Cardiac failure congestive 14.01 10.90 179 128964 85423 42406769
Mood altered 14.00 10.90 67 129076 10651 42481541
Forced expiratory volume decreased 13.99 10.90 3 129140 7627 42484565
Self esteem decreased 13.90 10.90 12 129131 510 42491682
Product use issue 13.90 10.90 157 128986 76594 42415598
Logorrhoea 13.87 10.90 28 129115 2779 42489413
Diabetes mellitus 13.79 10.90 116 129027 59971 42432221
Liver function test abnormal 13.77 10.90 51 129092 32340 42459852
Abdominal pain 13.77 10.90 456 128687 190015 42302177
Body temperature decreased 13.75 10.90 14 129129 14399 42477793
Blood triglycerides decreased 13.69 10.90 7 129136 120 42492072
Bladder cancer 13.66 10.90 19 129124 17028 42475164
Rhabdomyolysis 13.63 10.90 321 128822 77698 42414494
Chronic fatigue syndrome 13.60 10.90 10 129133 336 42491856
Colitis 13.55 10.90 84 129059 46488 42445704
Acute pulmonary oedema 13.49 10.90 57 129086 8594 42483598
Acidosis 13.41 10.90 73 129070 12206 42479986
Cardiorenal syndrome 13.40 10.90 15 129128 878 42491314
Nodule 13.35 10.90 11 129132 12523 42479669
Anticholinergic syndrome 13.30 10.90 20 129123 1569 42490623
Metastases to liver 13.28 10.90 18 129125 16308 42475884
BK virus infection 13.26 10.90 5 129138 8779 42483413
Peripheral nerve paresis 13.26 10.90 5 129138 39 42492153
Cyclothymic disorder 13.24 10.90 7 129136 129 42492063
Anhedonia 13.24 10.90 52 129091 7588 42484604
Venous injury 13.22 10.90 10 129133 351 42491841
Renal tubular necrosis 13.22 10.90 22 129121 18332 42473860
Transaminases increased 13.19 10.90 53 129090 32832 42459360
Multiple-drug resistance 13.19 10.90 3 129140 7319 42484873
Device related infection 13.09 10.90 26 129117 20253 42471939
Distractibility 13.08 10.90 11 129132 451 42491741
Pneumonia bacterial 13.07 10.90 17 129126 15675 42476517
Malaise 13.05 10.90 518 128625 211638 42280554
Poor venous access 13.00 10.90 3 129140 7249 42484943
Erythema multiforme 12.99 10.90 7 129136 9970 42482222
Intentional product use issue 12.98 10.90 147 128996 71686 42420506
Urosepsis 12.79 10.90 16 129127 15004 42477188
Foetal exposure timing unspecified 12.76 10.90 9 129134 283 42491909
Emotional distress 12.72 10.90 88 129055 16005 42476187
Ear infection 12.72 10.90 12 129131 12792 42479400
Syringe issue 12.70 10.90 5 129138 8551 42483641
Cardiopulmonary failure 12.65 10.90 37 129106 4646 42487546
Drug screen negative 12.65 10.90 8 129135 209 42491983
Cytopenia 12.57 10.90 21 129122 17476 42474716
Hypocalcaemia 12.51 10.90 48 129095 30125 42462067
Haemoconcentration 12.45 10.90 5 129138 47 42492145
Reduced facial expression 12.41 10.90 19 129124 1514 42490678
Oropharyngeal oedema 12.39 10.90 6 129137 91 42492101
Hepatitis acute 12.38 10.90 57 129086 8918 42483274
Clostridium difficile infection 12.23 10.90 32 129111 22627 42469565
Drug-induced liver injury 12.22 10.90 67 129076 38206 42453986
Metastases to lung 12.20 10.90 10 129133 11414 42480778
Hyperacusis 12.18 10.90 15 129128 972 42491220
Obsessive thoughts 12.17 10.90 14 129129 844 42491348
Haemolysis 12.09 10.90 7 129136 9582 42482610
Inflammation 12.09 10.90 57 129086 33790 42458402
Measles 12.05 10.90 9 129134 310 42491882
Depressed mood 12.05 10.90 116 129027 23268 42468924
SARS-CoV-2 test positive 11.98 10.90 5 129138 8255 42483937
Urinary retention 11.94 10.90 187 128956 42027 42450165
Hyponatraemia 11.91 10.90 226 128917 101236 42390956
Sepsis pasteurella 11.88 10.90 3 129140 4 42492188
Foreign body 11.87 10.90 15 129128 998 42491194
Pericardial effusion 11.86 10.90 47 129096 29228 42462964
Electrocardiogram T wave amplitude increased 11.83 10.90 6 129137 101 42492091
Cerebral congestion 11.83 10.90 6 129137 101 42492091
Osteonecrosis of jaw 11.81 10.90 25 129118 19024 42473168
Chloasma 11.79 10.90 4 129139 22 42492170
Alcohol withdrawal syndrome 11.77 10.90 18 129125 1433 42490759
Urinary tract infection 11.70 10.90 221 128922 99063 42393129
Incoherent 11.70 10.90 36 129107 4649 42487543
Vasculitis 11.52 10.90 24 129119 18370 42473822
Prothrombin level decreased 11.49 10.90 16 129127 1170 42491022
Respiratory tract infection 11.48 10.90 41 129102 26281 42465911
Hypercapnia 11.40 10.90 39 129104 5322 42486870
Oesophageal disorder 11.39 10.90 17 129126 1325 42490867
Anticipatory anxiety 11.36 10.90 4 129139 25 42492167
Thrombotic microangiopathy 11.32 10.90 17 129126 14765 42477427
Haemophagocytic lymphohistiocytosis 11.22 10.90 24 129119 18198 42473994
Acute stress disorder 11.20 10.90 7 129136 179 42492013
Skin toxicity 11.18 10.90 3 129140 6546 42485646
Drug level below therapeutic 11.17 10.90 3 129140 6542 42485650
Metastases to central nervous system 11.14 10.90 9 129134 10346 42481846
Benign mesenteric neoplasm 11.13 10.90 3 129140 6 42492186
Erectile dysfunction 11.12 10.90 120 129023 24793 42467399
Gingival erosion 11.10 10.90 4 129139 27 42492165
Pemphigoid 11.10 10.90 11 129132 11456 42480736
Environmental exposure 11.09 10.90 8 129135 261 42491931
Skin exfoliation 11.05 10.90 77 129066 41476 42450716
Sleep apnoea syndrome 11.04 10.90 107 129036 21501 42470691
Vascular purpura 11.03 10.90 22 129121 2164 42490028
Femoral artery aneurysm 11.03 10.90 7 129136 184 42492008
Intrusive thoughts 10.99 10.90 10 129133 456 42491736
Enteritis 10.91 10.90 10 129133 10806 42481386

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug abuse 15867.86 9.81 8667 334601 168744 110077287
Completed suicide 8810.09 9.81 6725 336543 235656 110010375
Toxicity to various agents 6001.36 9.81 7404 335864 473151 109772880
Respiratory arrest 3963.55 9.81 2389 340879 55910 110190121
Sopor 3435.25 9.81 1851 341417 34695 110211336
Poisoning 2810.49 9.81 1501 341767 27604 110218427
Cardio-respiratory arrest 2725.88 9.81 2506 340762 113330 110132701
Intentional overdose 2436.82 9.81 2504 340764 129997 110116034
Suicide attempt 2407.50 9.81 2224 341044 101170 110144861
Coma 2158.97 9.81 2223 341045 115646 110130385
Cardiac arrest 2158.30 9.81 2850 340418 193903 110052128
Poisoning deliberate 1971.44 9.81 1149 342119 25182 110220849
Overdose 1649.33 9.81 2753 340515 231041 110014990
Intentional product misuse 1635.51 9.81 2039 341229 130865 110115166
Drug dependence 1623.94 9.81 1302 341966 48718 110197313
Somnolence 1126.28 9.81 2701 340567 294748 109951283
Drug use disorder 1093.24 9.81 688 342580 17386 110228645
Intentional self-injury 982.54 9.81 862 342406 36567 110209464
Death 638.56 9.81 4027 339241 694842 109551189
Pemphigus 632.40 9.81 6 343262 214564 110031467
Drug withdrawal syndrome 625.35 9.81 678 342590 37376 110208655
Hand deformity 618.47 9.81 12 343256 218494 110027537
Synovitis 575.47 9.81 83 343185 274009 109972022
Off label use 544.08 9.81 2606 340662 1497579 108748452
Anti-cyclic citrullinated peptide antibody positive 541.53 9.81 4 343264 181980 110064051
Systemic lupus erythematosus 536.32 9.81 76 343192 254262 109991769
Substance abuse 533.92 9.81 383 342885 12080 110233951
Duodenal ulcer perforation 528.31 9.81 4 343264 177696 110068335
Withdrawal syndrome 518.95 9.81 561 342707 30819 110215212
Lower respiratory tract infection 511.77 9.81 73 343195 243033 110002998
Pericarditis 500.19 9.81 50 343218 219064 110026967
Exposure via ingestion 499.06 9.81 262 343006 4638 110241393
Helicobacter infection 488.43 9.81 17 343251 181860 110064171
Glossodynia 461.87 9.81 69 343199 221935 110024096
Suicidal ideation 460.76 9.81 947 342321 92990 110153041
Folliculitis 449.05 9.81 16 343252 167637 110078394
Drug ineffective 419.13 9.81 2886 340382 1517654 108728377
Bradyphrenia 418.63 9.81 323 342945 11405 110234626
Depressed level of consciousness 404.28 9.81 1001 342267 111277 110134754
Agitation 398.75 9.81 1000 342268 112051 110133980
Miosis 382.90 9.81 404 342864 21579 110224452
C-reactive protein abnormal 380.36 9.81 4 343264 129691 110116340
Mydriasis 373.18 9.81 400 342868 21757 110224274
Arthropathy 367.86 9.81 218 343050 287304 109958727
Drug abuser 365.46 9.81 221 343047 5188 110240843
Rheumatic fever 358.47 9.81 4 343264 122575 110123456
Muscle injury 349.56 9.81 22 343246 140785 110105246
Nasopharyngitis 348.32 9.81 427 342841 393934 109852097
Maternal exposure during pregnancy 343.72 9.81 181 343087 254702 109991329
Joint swelling 336.72 9.81 534 342734 442311 109803720
Loss of consciousness 336.45 9.81 1353 341915 194953 110051078
Altered state of consciousness 334.84 9.81 624 342644 57002 110189029
Wound 330.39 9.81 157 343111 234280 110011751
Swelling 325.10 9.81 366 342902 350675 109895356
Accidental overdose 319.76 9.81 576 342692 51258 110194773
Drug intolerance 302.60 9.81 497 342771 406015 109840016
Psoriatic arthropathy 297.47 9.81 119 343149 196642 110049389
Sleep disorder due to general medical condition, insomnia type 290.36 9.81 8 343260 105635 110140396
Wheezing 284.48 9.81 225 343043 255005 109991026
Substance use disorder 282.77 9.81 211 343057 7079 110238952
Bradypnoea 276.00 9.81 223 343045 8426 110237605
Stomatitis 273.60 9.81 261 343007 269981 109976050
Impaired healing 270.69 9.81 136 343132 196581 110049450
Irritable bowel syndrome 267.41 9.81 88 343180 164127 110081904
Facet joint syndrome 267.36 9.81 7 343261 96821 110149210
General physical health deterioration 261.43 9.81 583 342685 424712 109821319
Anxiety 258.24 9.81 1895 341373 343183 109902848
Respiratory depression 258.06 9.81 401 342867 31600 110214431
Treatment failure 252.33 9.81 293 342975 276941 109969090
Lip dry 250.32 9.81 15 343253 100068 110145963
Blister 245.24 9.81 207 343061 227169 110018862
Febrile neutropenia 242.51 9.81 380 342888 316387 109929644
Rheumatoid factor positive 237.55 9.81 58 343210 131582 110114449
Myelosuppression 236.38 9.81 14 343254 94326 110151705
Contraindicated product administered 233.99 9.81 255 343013 248012 109998019
Abdominal discomfort 233.07 9.81 551 342717 393307 109852724
Breast cancer stage III 229.45 9.81 3 343265 79114 110166917
Gastrointestinal disorder 223.11 9.81 253 343015 241699 110004332
Infection 221.32 9.81 498 342770 361702 109884329
Infusion related reaction 220.97 9.81 539 342729 380623 109865408
Joint range of motion decreased 219.22 9.81 54 343214 121778 110124253
Therapeutic product effect decreased 218.26 9.81 262 343006 244054 110001977
Alopecia 217.63 9.81 508 342760 364245 109881786
Disturbance in attention 210.83 9.81 541 342727 61454 110184577
Victim of chemical submission 210.05 9.81 85 343183 794 110245237
Discomfort 208.51 9.81 215 343053 214492 110031539
Liver injury 208.41 9.81 103 343165 150310 110095721
Type 2 diabetes mellitus 208.05 9.81 148 343120 177084 110068947
Arthralgia 203.78 9.81 1500 341768 778132 109467899
Ill-defined disorder 201.83 9.81 118 343150 156735 110089296
Depression 200.53 9.81 1676 341592 315659 109930372
Panic attack 197.17 9.81 336 342932 28604 110217427
Dissociation 197.05 9.81 195 343073 9647 110236384
Mobility decreased 196.17 9.81 270 342998 237152 110008879
Wound infection 195.97 9.81 32 343236 96433 110149598
Grip strength decreased 194.65 9.81 14 343254 80160 110165871
Fibromyalgia 193.78 9.81 148 343120 170761 110075270
Sedation 192.06 9.81 563 342705 69120 110176911
Tremor 191.68 9.81 1178 342090 201054 110044977
Drug screen positive 189.31 9.81 158 343110 6252 110239779
Bradykinesia 189.18 9.81 199 343069 10589 110235442
Prescription form tampering 187.86 9.81 68 343200 453 110245578
Peripheral venous disease 187.25 9.81 21 343247 84096 110161935
Drug interaction 186.44 9.81 2371 340897 497812 109748219
Peripheral swelling 183.45 9.81 641 342627 403393 109842638
Product use in unapproved indication 182.22 9.81 742 342526 446635 109799396
Suspected suicide 181.58 9.81 230 343038 14969 110231062
Live birth 181.39 9.81 8 343260 69476 110176555
Sinusitis 175.50 9.81 415 342853 296273 109949758
C-reactive protein increased 174.87 9.81 253 343015 217666 110028365
Hypersensitivity 174.78 9.81 654 342614 403344 109842687
Alcohol abuse 172.10 9.81 134 343134 4795 110241236
Aggression 165.68 9.81 481 342787 58729 110187302
Hepatic enzyme increased 162.40 9.81 485 342783 320407 109925624
Pneumonia 160.41 9.81 1845 341423 874869 109371162
Inflammation 160.37 9.81 219 343049 193019 110053012
Urticaria 157.73 9.81 487 342781 318370 109927661
Rheumatoid arthritis 156.59 9.81 446 342822 299167 109946864
Musculoskeletal stiffness 154.88 9.81 405 342863 279417 109966614
Condition aggravated 145.67 9.81 1518 341750 733318 109512713
Intentional product use issue 144.81 9.81 349 342919 247557 109998474
Disorientation 143.16 9.81 514 342754 70157 110175874
Osteoarthritis 139.76 9.81 219 343049 182404 110063627
Electrocardiogram QT prolonged 139.66 9.81 689 342579 108271 110137760
Rash 139.30 9.81 1756 341512 819208 109426823
Blood cholesterol increased 138.20 9.81 225 343043 184560 110061471
Psychomotor hyperactivity 132.34 9.81 231 343037 20046 110225985
Liver disorder 130.79 9.81 149 343119 142094 110103937
Abnormal behaviour 129.96 9.81 338 342930 38701 110207330
Unresponsive to stimuli 129.25 9.81 464 342804 63326 110182705
Accidental death 124.71 9.81 112 343156 4897 110241134
Pyrexia 124.28 9.81 2001 341267 896264 109349767
Autoimmune disorder 121.80 9.81 27 343241 65456 110180575
Bone erosion 118.90 9.81 6 343262 46365 110199666
Hallucination, visual 118.85 9.81 330 342938 39275 110206756
Serotonin syndrome 115.39 9.81 425 342843 58728 110187303
Alcohol interaction 115.24 9.81 94 343174 3600 110242431
Hepatocellular injury 113.58 9.81 381 342887 50261 110195770
Nail disorder 109.57 9.81 23 343245 57912 110188119
COVID-19 108.33 9.81 393 342875 244667 110001364
Onychomadesis 107.95 9.81 9 343259 45654 110200377
Drug resistance 107.40 9.81 22 343246 56352 110189679
Hypercholesterolaemia 106.38 9.81 76 343192 90761 110155270
Dependence 105.87 9.81 79 343189 2650 110243381
Fall 105.49 9.81 2534 340734 600948 109645083
Hyperhidrosis 103.06 9.81 960 342308 186338 110059693
Cough 101.27 9.81 930 342338 460711 109785320
Night sweats 101.24 9.81 162 343106 133821 110112210
Liver function test increased 101.21 9.81 76 343192 88472 110157559
X-ray abnormal 100.79 9.81 4 343264 38113 110207918
Therapy non-responder 100.36 9.81 211 343057 157096 110088935
Cytomegalovirus infection 100.15 9.81 23 343245 54421 110191610
Sciatica 99.72 9.81 84 343184 92315 110153716
Bezoar 99.66 9.81 90 343178 3964 110242067
Hypokinesia 98.77 9.81 213 343055 21613 110224418
Asphyxia 95.46 9.81 164 343104 14051 110231980
Feeling abnormal 95.33 9.81 918 342350 179793 110066238
Lower limb fracture 95.05 9.81 58 343210 75290 110170741
Obesity 93.48 9.81 129 343139 113222 110132809
Taste disorder 93.27 9.81 43 343225 65344 110180687
Nervousness 92.37 9.81 288 342980 36563 110209468
Prescription drug used without a prescription 92.15 9.81 99 343169 5397 110240634
Persistent genital arousal disorder 92.00 9.81 44 343224 632 110245399
Speech disorder 91.10 9.81 406 342862 61163 110184868
Foetal death 91.00 9.81 172 343096 15873 110230158
Knee arthroplasty 89.15 9.81 45 343223 64903 110181128
Irritability 88.67 9.81 338 342930 47471 110198560
Anticholinergic syndrome 87.92 9.81 86 343182 4194 110241837
Dyspnoea 87.60 9.81 2693 340575 1104179 109141852
Hallucination 87.47 9.81 577 342691 100855 110145176
Musculoskeletal pain 87.32 9.81 284 342984 182739 110063292
Mucosal inflammation 85.91 9.81 103 343165 96038 110149993
Drug-induced liver injury 85.34 9.81 151 343117 119916 110126115
Gait inability 85.26 9.81 185 343083 136191 110109840
Oedema 84.91 9.81 349 342919 209627 110036404
Euphoric mood 84.65 9.81 120 343148 8707 110237324
Insomnia 84.28 9.81 1580 341688 359010 109887021
Vaginal flatulence 84.05 9.81 142 343126 12002 110234029
Hypotension 83.57 9.81 2173 341095 521676 109724355
Psychomotor skills impaired 83.04 9.81 106 343162 6952 110239079
Thinking abnormal 83.04 9.81 160 343108 14980 110231051
Anhedonia 82.13 9.81 161 343107 15267 110230764
Sepsis 81.85 9.81 637 342631 326709 109919322
Vertigo 80.96 9.81 504 342764 86366 110159665
Drug hypersensitivity 79.95 9.81 963 342305 453127 109792904
Blepharospasm 79.92 9.81 35 343233 54816 110191215
Dry mouth 79.81 9.81 334 342934 199614 110046417
Toxicologic test abnormal 79.64 9.81 50 343218 1257 110244774
Homicide 79.42 9.81 47 343221 1059 110244972
Respiratory acidosis 79.39 9.81 149 343119 13677 110232354
Drug detoxification 79.19 9.81 38 343230 550 110245481
Urinary retention 79.10 9.81 426 342842 69257 110176774
Self-medication 78.75 9.81 97 343171 6135 110239896
Psychomotor retardation 77.80 9.81 108 343160 7684 110238347
Renal impairment 77.58 9.81 311 342957 188134 110057897
Dysarthria 77.12 9.81 486 342782 83635 110162396
Victim of crime 77.05 9.81 50 343218 1333 110244698
Pneumonia aspiration 76.78 9.81 473 342795 80760 110165271
Pulmonary congestion 76.68 9.81 241 343027 30725 110215306
Crying 76.36 9.81 213 343055 25415 110220616
Hip arthroplasty 76.12 9.81 39 343229 55774 110190257
Onychomycosis 75.59 9.81 14 343254 38517 110207514
Product use issue 75.40 9.81 612 342656 311083 109934948
Neutropenia 74.82 9.81 772 342496 373848 109872183
Macular degeneration 74.65 9.81 190 343078 21469 110224562
Counterfeit product administered 73.89 9.81 29 343239 248 110245783
Finger deformity 71.82 9.81 9 343259 33083 110212948
Vaginal discharge 71.22 9.81 166 343102 17742 110228289
Disease progression 70.70 9.81 455 342813 243579 110002452
Neutropenic sepsis 70.16 9.81 7 343261 30739 110215292
Stupor 70.05 9.81 106 343162 8159 110237872
Lupus-like syndrome 69.73 9.81 20 343248 40772 110205259
Proctitis 69.62 9.81 159 343109 16768 110229263
Major depression 69.31 9.81 121 343147 10500 110235531
Radiculopathy 69.13 9.81 172 343096 19164 110226867
Foot deformity 68.96 9.81 32 343236 48448 110197583
Accidental poisoning 68.72 9.81 59 343209 2428 110243603
Lung disorder 68.05 9.81 307 342961 179740 110066291
Neutrophil count decreased 67.66 9.81 174 343094 120767 110125264
Malignant neoplasm progression 67.58 9.81 295 342973 174272 110071759
Postmortem blood drug level abnormal 67.40 9.81 35 343233 605 110245426
Hypothermia 67.25 9.81 207 343061 26095 110219936
Temperature regulation disorder 67.25 9.81 133 343135 12693 110233338
Inappropriate schedule of product administration 66.76 9.81 365 342903 203272 110042759
Asthma 65.42 9.81 481 342787 249810 109996221
Inappropriate antidiuretic hormone secretion 65.00 9.81 242 343026 33609 110212422
Substance abuser 64.77 9.81 31 343237 446 110245585
Chronic sinusitis 64.69 9.81 198 343070 24886 110221145
Female genital tract fistula 64.47 9.81 152 343116 16367 110229664
Emotional distress 64.30 9.81 293 342975 44554 110201477
Alcohol use 63.47 9.81 71 343197 4051 110241980
Red blood cell sedimentation rate abnormal 63.38 9.81 3 343265 24506 110221525
Pulmonary fibrosis 63.30 9.81 139 343129 101903 110144128
Obstructive airways disorder 63.30 9.81 32 343236 46117 110199914
Respiratory rate decreased 62.88 9.81 87 343181 6171 110239860
Product counterfeit 62.60 9.81 27 343241 300 110245731
Analgesic drug level increased 62.53 9.81 69 343199 3877 110242154
Substance use 60.36 9.81 55 343213 2451 110243580
Procedural pain 59.94 9.81 244 343024 35321 110210710
Weight increased 59.79 9.81 929 342339 418715 109827316
Osmolar gap increased 59.61 9.81 23 343245 187 110245844
Paraesthesia oral 59.14 9.81 234 343034 33437 110212594
Bradycardia 58.95 9.81 740 342528 154777 110091254
Blood pressure fluctuation 58.88 9.81 88 343180 74736 110171295
Gastrooesophageal reflux disease 58.22 9.81 324 342944 179652 110066379
Pregnancy 58.14 9.81 44 343224 51023 110195008
Constipation 57.52 9.81 1486 341782 356300 109889731
Drug ineffective for unapproved indication 57.49 9.81 148 343120 102690 110143341
Platelet count decreased 57.31 9.81 449 342819 229994 110016037
Sluggishness 57.10 9.81 92 343176 7475 110238556
Hallucination, auditory 56.90 9.81 196 343072 26201 110219830
Anger 56.66 9.81 158 343110 18849 110227182
Bursitis 56.30 9.81 210 343058 129708 110116323
Hyporesponsive to stimuli 56.02 9.81 56 343212 2804 110243227
Adverse drug reaction 55.93 9.81 156 343112 105403 110140628
Pruritus 55.89 9.81 1376 341892 580184 109665847
Blood pressure systolic increased 55.75 9.81 108 343160 82883 110163148
Drug withdrawal convulsions 55.59 9.81 52 343216 2397 110243634
Pain in extremity 55.51 9.81 1122 342146 485996 109760035
Hallucinations, mixed 55.39 9.81 98 343170 8595 110237436
Fear 54.24 9.81 177 343091 23016 110223015
Muscular weakness 54.22 9.81 501 342767 247967 109998064
Rhabdomyolysis 54.11 9.81 592 342676 119809 110126222
Cognitive disorder 54.00 9.81 460 342808 87051 110158980
Laryngitis 53.00 9.81 33 343235 42378 110203653
Contusion 52.02 9.81 468 342800 232893 110013138
Diarrhoea 51.80 9.81 2952 340316 1136553 109109478
Red blood cell sedimentation rate increased 51.65 9.81 103 343165 78199 110167832
Restlessness 51.54 9.81 325 342943 55934 110190097
Cytokine release syndrome 51.25 9.81 87 343181 70219 110175812
Sinus tachycardia 50.49 9.81 272 342996 44221 110201810
Abdominal pain upper 50.00 9.81 772 342496 348339 109897692
Substance dependence 49.95 9.81 30 343238 695 110245336
Hepatic cirrhosis 49.92 9.81 83 343185 67543 110178488
Bronchiectasis 49.02 9.81 26 343242 36467 110209564
Brain oedema 49.00 9.81 209 343059 30889 110215142
Mania 48.90 9.81 159 343109 20637 110225394
Panic disorder 48.87 9.81 57 343211 3404 110242627
Sinus bradycardia 48.68 9.81 201 343067 29282 110216749
Pulmonary oedema 48.53 9.81 502 342766 100157 110145874
Pancytopenia 48.21 9.81 417 342851 209196 110036835
Depressed mood 47.71 9.81 338 342930 60471 110185560
Blood pressure diastolic decreased 47.57 9.81 26 343242 35859 110210172
Inadequate analgesia 47.19 9.81 68 343200 5009 110241022
Poverty of speech 47.02 9.81 27 343241 574 110245457
Therapeutic product effect incomplete 46.39 9.81 457 342811 223348 110022683
Wrong patient received product 46.13 9.81 78 343190 6596 110239435
Hypoaesthesia 45.96 9.81 692 342576 313531 109932500
Ascites 45.66 9.81 142 343126 92666 110153365
Extrapyramidal disorder 45.48 9.81 194 343074 28673 110217358
Ear infection 45.38 9.81 78 343190 62654 110183377
Arthritis 45.26 9.81 319 342949 167267 110078764
Maternal exposure timing unspecified 44.91 9.81 6 343262 21007 110225024
Lethargy 44.79 9.81 466 342802 93110 110152921
Joint stiffness 43.88 9.81 89 343179 67154 110178877
Hypoglycaemia 43.80 9.81 552 342716 115552 110130479
Mental disorder 43.24 9.81 236 343032 38555 110207476
Catatonia 43.04 9.81 103 343165 11197 110234834
Normal newborn 42.85 9.81 8 343260 21888 110224143
Cyanosis 42.40 9.81 194 343074 29547 110216484
Confusional state 42.17 9.81 1818 341450 466862 109779169
Therapy partial responder 42.10 9.81 32 343236 37029 110209002
Hyponatraemia 41.64 9.81 926 342342 216727 110029304
Head injury 41.60 9.81 252 343016 42765 110203266
Electrocardiogram QRS complex prolonged 41.57 9.81 111 343157 12910 110233121
Parkinsonism 41.26 9.81 157 343111 22030 110224001
Hepatic function abnormal 40.90 9.81 141 343127 89154 110156877
Sudden death 40.82 9.81 167 343101 24228 110221803
Cytomegalovirus viraemia 40.65 9.81 4 343264 17760 110228271
Infusion site reaction 40.41 9.81 4 343264 17678 110228353
Food allergy 40.31 9.81 145 343123 19803 110226228
Adverse event 40.23 9.81 187 343081 108622 110137409
Anaphylactic reaction 40.18 9.81 200 343068 114100 110131931
Chemical submission 39.96 9.81 24 343244 556 110245475
Sleep disorder 39.76 9.81 409 342859 198235 110047796
Aplastic anaemia 39.60 9.81 13 343255 24295 110221736
Pneumocystis jirovecii pneumonia 39.01 9.81 45 343223 42690 110203341
Amnesia 38.85 9.81 499 342769 104909 110141122
Mood altered 38.72 9.81 150 343118 21225 110224806
Tachycardia 38.66 9.81 949 342319 225696 110020335
Transplant rejection 38.53 9.81 14 343254 24553 110221478
Full blood count abnormal 38.47 9.81 72 343196 55980 110190051
Sleep disorder due to a general medical condition 38.43 9.81 64 343204 52048 110193983
Impaired driving ability 38.27 9.81 70 343198 6300 110239731
Exostosis 38.18 9.81 52 343216 45904 110200127
Cholecystitis chronic 37.71 9.81 88 343180 9412 110236619
Anorgasmia 37.46 9.81 35 343233 1611 110244420
Herpes zoster 37.32 9.81 191 343077 108188 110137843
Dissociative disorder 37.28 9.81 31 343237 1220 110244811
Adrenal insufficiency 37.25 9.81 46 343222 42344 110203687
Suicidal behaviour 37.23 9.81 50 343218 3447 110242584
Incoherent 37.17 9.81 81 343187 8277 110237754
Seizure 37.09 9.81 924 342344 220261 110025770
Delusion 36.93 9.81 159 343109 23596 110222435
Dyskinesia 36.39 9.81 279 342989 51167 110194864
Generalised anxiety disorder 36.32 9.81 44 343224 2735 110243296
Gun shot wound 36.18 9.81 29 343239 1083 110244948
Hypersomnia 35.62 9.81 177 343091 27884 110218147
Dysphoria 35.33 9.81 68 343200 6360 110239671
Coma scale abnormal 35.28 9.81 87 343181 9639 110236392
Blood pressure diastolic abnormal 35.26 9.81 18 343250 25797 110220234
Exposure during pregnancy 34.63 9.81 342 342926 167082 110078949
Initial insomnia 34.63 9.81 90 343178 10299 110235732
Multiple injuries 34.46 9.81 49 343219 3565 110242466
Appendicitis 34.40 9.81 23 343245 28441 110217590
Logorrhoea 34.35 9.81 58 343210 4899 110241132
Myoclonus 34.29 9.81 197 343071 32801 110213230
Andropause 34.09 9.81 13 343255 102 110245929
Manic symptom 33.52 9.81 17 343251 279 110245752
Slow speech 33.25 9.81 47 343221 3401 110242630
Mental status changes 33.15 9.81 372 342896 75750 110170281
Septic shock 32.91 9.81 321 342947 157207 110088824
Prostate cancer 32.91 9.81 41 343227 37600 110208431
Apathy 32.78 9.81 118 343150 16121 110229910
Body temperature decreased 32.54 9.81 40 343228 36895 110209136
Haemophagocytic lymphohistiocytosis 32.47 9.81 30 343238 31529 110214502
Back injury 32.43 9.81 61 343207 47338 110198693
Adjustment disorder with mixed anxiety and depressed mood 32.35 9.81 13 343255 119 110245912
Blood cholesterol decreased 32.28 9.81 41 343227 2675 110243356
Obsessive thoughts 32.10 9.81 29 343239 1278 110244753
Hospitalisation 32.08 9.81 285 342983 142208 110103823
Dysuria 31.75 9.81 306 342962 59925 110186106
Narcotic bowel syndrome 31.53 9.81 16 343252 263 110245768
Metastases to liver 31.51 9.81 38 343230 35348 110210683
Neuroleptic malignant syndrome 31.35 9.81 197 343071 33862 110212169
Cytomegalovirus infection reactivation 31.31 9.81 9 343259 18324 110227707
Hyperthermia 31.26 9.81 140 343128 21132 110224899
Venoocclusive liver disease 30.98 9.81 5 343263 15202 110230829
Neurotoxicity 30.97 9.81 52 343216 42155 110203876
Obsessive-compulsive disorder 30.87 9.81 69 343199 7172 110238859
Blood test abnormal 30.75 9.81 26 343242 28528 110217503
Drug diversion 30.75 9.81 29 343239 1351 110244680
Feeling jittery 30.59 9.81 108 343160 14614 110231417
Multiple organ dysfunction syndrome 30.51 9.81 312 342956 151398 110094633
Multiple-drug resistance 30.23 9.81 3 343265 13232 110232799
Forced expiratory volume decreased 30.06 9.81 3 343265 13173 110232858
Cardiac failure 29.96 9.81 406 342862 187220 110058811
Yawning 29.77 9.81 30 343238 1517 110244514
Cardiogenic shock 29.58 9.81 290 342978 57048 110188983
Bacteraemia 29.49 9.81 54 343214 42336 110203695
Distributive shock 29.49 9.81 60 343208 5844 110240187
Underdose 29.34 9.81 100 343168 63454 110182577
Aspergillus infection 29.25 9.81 22 343246 25594 110220437
Burning sensation 29.13 9.81 336 342932 68876 110177155
Ulcer haemorrhage 28.99 9.81 17 343251 22554 110223477
Foreign body aspiration 28.97 9.81 19 343249 516 110245515
Feeling hot 28.92 9.81 165 343103 90941 110155090
Alcohol poisoning 28.90 9.81 77 343191 8943 110237088
Nervous system disorder 28.90 9.81 183 343085 31538 110214493
Productive cough 28.74 9.81 222 343046 114083 110131948
Homicidal ideation 28.61 9.81 45 343223 3582 110242449
Conversion disorder 28.52 9.81 36 343232 2334 110243697
Oral candidiasis 28.52 9.81 237 343031 44523 110201508
Thermal burn 28.49 9.81 71 343197 7917 110238114
Multiple sclerosis relapse 28.36 9.81 259 343009 49981 110196050
Suspected counterfeit product 28.33 9.81 22 343246 784 110245247
Abulia 28.13 9.81 27 343241 1286 110244745
Walking aid user 28.04 9.81 22 343246 25053 110220978
Diabetic ketoacidosis 28.01 9.81 55 343213 42003 110204028
Bipolar I disorder 27.99 9.81 35 343233 2248 110243783
Generalised tonic-clonic seizure 27.94 9.81 276 342992 54404 110191627
Neuroglycopenia 27.68 9.81 25 343243 1101 110244930
Cardio-respiratory distress 27.62 9.81 15 343253 285 110245746
Hyperleukocytosis 27.59 9.81 43 343225 3396 110242635
Hypotonia 26.51 9.81 108 343160 15637 110230394
Housebound 26.44 9.81 17 343251 446 110245585
Victim of sexual abuse 26.44 9.81 18 343250 521 110245510
Injury 26.38 9.81 389 342879 176876 110069155
Pulmonary toxicity 26.37 9.81 11 343257 17735 110228296
Paramnesia 26.28 9.81 8 343260 28 110246003
Premature delivery 26.12 9.81 34 343234 30598 110215433
Immobilisation prolonged 26.09 9.81 12 343256 157 110245874
Puncture site haematoma 26.07 9.81 14 343254 260 110245771
Cardiomegaly 25.89 9.81 167 343101 28963 110217068
Angioedema 25.85 9.81 189 343079 98311 110147720
Peripheral circulatory failure 25.75 9.81 30 343238 1789 110244242
Feeling of despair 25.74 9.81 44 343224 3754 110242277
Reduced facial expression 25.68 9.81 43 343225 3608 110242423
Hypokalaemia 25.67 9.81 745 342523 181703 110064328
Blood alcohol increased 25.66 9.81 23 343245 1003 110245028
Bronchopulmonary aspergillosis 25.62 9.81 33 343235 29830 110216201
Withdrawal catatonia 25.53 9.81 16 343252 401 110245630
Product substitution issue 25.50 9.81 140 343128 22921 110223110
Nasal polyps 25.46 9.81 5 343263 13195 110232836
Formication 25.42 9.81 55 343213 5593 110240438
Apraxia 25.31 9.81 42 343226 3498 110242533
Chemical poisoning 25.24 9.81 12 343256 170 110245861
Adverse reaction 25.08 9.81 33 343235 29561 110216470
Somnambulism 25.06 9.81 59 343209 6346 110239685
Diffuse large B-cell lymphoma 25.04 9.81 9 343259 15889 110230142
Injection site reaction 24.80 9.81 168 343100 88902 110157129
Drug tolerance increased 24.78 9.81 18 343250 579 110245452
Hypochloraemia 24.63 9.81 42 343226 3576 110242455
Osteoporosis 24.46 9.81 164 343104 86988 110159043
Renal papillary necrosis 24.44 9.81 16 343252 433 110245598
White blood cell count decreased 24.43 9.81 534 342734 228856 110017175
Nightmare 24.35 9.81 205 343063 38658 110207373
Tenosynovitis 24.34 9.81 10 343258 16273 110229758
Uveitis 24.34 9.81 19 343249 21691 110224340
Hallucination, gustatory 24.24 9.81 9 343259 65 110245966
Epilepsy 24.09 9.81 197 343071 100012 110146019
Alcoholism 23.89 9.81 42 343226 3665 110242366
Exposure via inhalation 23.60 9.81 10 343258 106 110245925
Delirium 23.50 9.81 567 342701 134458 110111573
Hepatic cytolysis 23.50 9.81 268 343000 54785 110191246
Influenza 23.49 9.81 376 342892 168725 110077306
Tumour lysis syndrome 23.49 9.81 37 343231 30764 110215267
Drug dose omission by device 23.23 9.81 8 343260 14508 110231523
BK virus infection 23.20 9.81 6 343262 13100 110232931
Leukoencephalopathy 23.17 9.81 72 343196 9123 110236908
Bladder dilatation 23.16 9.81 33 343235 2406 110243625
Blood pressure diastolic increased 23.00 9.81 15 343253 18792 110227239
Haemoglobin decreased 22.90 9.81 592 342676 248135 109997896
Product complaint 22.87 9.81 95 343173 13877 110232154
Blood pressure systolic abnormal 22.86 9.81 26 343242 24824 110221207
Thymus disorder 22.81 9.81 17 343251 569 110245462
Muscle rigidity 22.74 9.81 140 343128 23891 110222140
Blood uric acid increased 22.70 9.81 20 343248 21509 110224522
Chronic fatigue syndrome 22.67 9.81 25 343243 1404 110244627
Multiple sclerosis 22.64 9.81 147 343121 25551 110220480
Respiratory symptom 22.63 9.81 9 343259 14936 110231095
Tension 22.34 9.81 49 343219 5029 110241002
Poor venous access 22.19 9.81 26 343242 24496 110221535
Gas poisoning 21.88 9.81 9 343259 88 110245943
Toxic epidermal necrolysis 21.86 9.81 96 343172 56631 110189400
Hyperreflexia 21.83 9.81 72 343196 9413 110236618
Cardiac valve disease 21.79 9.81 56 343212 6365 110239666
Epstein-Barr virus infection 21.52 9.81 16 343252 18722 110227309
Self-injurious ideation 21.51 9.81 44 343224 4302 110241729
Partner stress 21.50 9.81 13 343255 305 110245726
Vestibular ischaemia 21.49 9.81 6 343262 14 110246017
Anxiety disorder 21.46 9.81 48 343220 4992 110241039
Tubulointerstitial nephritis 21.44 9.81 91 343177 54193 110191838
Gangrene 21.43 9.81 12 343256 16329 110229702
Bundle branch block right 21.25 9.81 85 343183 12206 110233825
Hyponatraemic encephalopathy 21.22 9.81 14 343254 384 110245647
Hepatotoxicity 21.12 9.81 113 343155 63287 110182744
Cutaneous T-cell dyscrasia 21.07 9.81 8 343260 62 110245969
Gastrointestinal haemorrhage 21.05 9.81 374 342894 165144 110080887
Upper gastrointestinal haemorrhage 21.03 9.81 82 343186 50014 110196017
Prothrombin level decreased 21.00 9.81 27 343241 1783 110244248
Benzodiazepine drug level abnormal 20.96 9.81 5 343263 4 110246027
Anaemia 20.96 9.81 1439 341829 545647 109700384
Oesophageal carcinoma 20.93 9.81 5 343263 11519 110234512
Joint dislocation 20.85 9.81 47 343221 34143 110211888
Feeling drunk 20.80 9.81 50 343218 5450 110240581
Hepatitis acute 20.80 9.81 114 343154 18652 110227379
Balance disorder 20.75 9.81 491 342777 116069 110129962
Disorganised speech 20.74 9.81 37 343231 3266 110242765
Prothrombin time shortened 20.57 9.81 39 343229 3607 110242424
Blood creatinine increased 20.57 9.81 422 342846 182467 110063564
Migraine 20.53 9.81 392 342876 171260 110074771
Disease recurrence 20.43 9.81 108 343160 60676 110185355
Atrioventricular block 20.40 9.81 105 343163 16772 110229259
Drug withdrawal maintenance therapy 20.29 9.81 10 343258 154 110245877
Hypoxic-ischaemic encephalopathy 20.22 9.81 67 343201 8780 110237251
Bacterial infection 20.21 9.81 74 343194 45962 110200069
Refusal of treatment by patient 20.03 9.81 70 343198 9424 110236607
Wrong patient 20.03 9.81 24 343244 1475 110244556
Carotid artery thrombosis 20.02 9.81 3 343265 9635 110236396
LDL/HDL ratio increased 19.97 9.81 5 343263 6 110246025
Cholestasis 19.93 9.81 296 342972 64222 110181809
Areflexia 19.91 9.81 56 343212 6713 110239318
Gambling disorder 19.86 9.81 29 343239 2162 110243869
Emotional disorder 19.85 9.81 101 343167 16059 110229972
Paraesthesia 19.77 9.81 681 342587 275840 109970191
Heart rate decreased 19.75 9.81 163 343105 82593 110163438
Pulmonary alveolar haemorrhage 19.75 9.81 20 343248 20130 110225901
Internal fixation of fracture 19.72 9.81 15 343253 518 110245513
Panic reaction 19.72 9.81 48 343220 5274 110240757
Cerebral congestion 19.71 9.81 11 343257 221 110245810
Purging 19.55 9.81 7 343261 45 110245986
Hypervolaemia 19.49 9.81 83 343185 49377 110196654
Perineal pain 19.44 9.81 24 343244 1521 110244510
Oropharyngeal pain 19.39 9.81 299 342969 134977 110111054
Foreign body 19.39 9.81 34 343234 2961 110243070
Tarsal tunnel syndrome 19.33 9.81 15 343253 534 110245497
Pupillary disorder 19.13 9.81 16 343252 635 110245396
Papillary muscle disorder 19.11 9.81 4 343264 0 110246031
Fatigue 19.10 9.81 3403 339865 1212555 109033476
Rhinorrhoea 19.08 9.81 215 343053 102451 110143580
Foaming at mouth 19.08 9.81 29 343239 2241 110243790
Cystitis haemorrhagic 19.08 9.81 7 343261 12202 110233829
Alcohol withdrawal syndrome 19.03 9.81 28 343240 2102 110243929
Pseudophaeochromocytoma 19.02 9.81 9 343259 126 110245905
Clostridium difficile infection 19.02 9.81 90 343178 52039 110193992
Blood lactate dehydrogenase increased 18.98 9.81 72 343196 44262 110201769
Confusional arousal 18.90 9.81 10 343258 180 110245851
Acute graft versus host disease in skin 18.85 9.81 5 343263 10735 110235296
Meningioma 18.80 9.81 49 343219 5616 110240415
Visceral congestion 18.74 9.81 22 343246 1323 110244708
Myelodysplastic syndrome 18.68 9.81 57 343211 37427 110208604
Deafness neurosensory 18.66 9.81 69 343199 9550 110236481
Nasal mucosal disorder 18.65 9.81 26 343242 1857 110244174
Vestibular disorder 18.51 9.81 31 343237 2601 110243430
Burning mouth syndrome 18.50 9.81 16 343252 665 110245366
Compartment syndrome 18.48 9.81 50 343218 5860 110240171
Tonic clonic movements 18.45 9.81 33 343235 2919 110243112
Victim of homicide 18.43 9.81 11 343257 252 110245779
Deafness 18.42 9.81 144 343124 26565 110219466
Brachial plexus injury 18.41 9.81 9 343259 136 110245895
Metastases to lung 18.26 9.81 27 343241 23036 110222995
Acute myeloid leukaemia 18.26 9.81 59 343209 38051 110207980
Sputum discoloured 18.22 9.81 37 343231 27908 110218123
Loss of personal independence in daily activities 18.13 9.81 342 342926 149678 110096353
Anion gap increased 18.08 9.81 41 343227 4303 110241728
Joint effusion 18.04 9.81 23 343245 20882 110225149
Unintentional medical device removal 18.03 9.81 3 343265 8920 110237111
Morbid thoughts 18.01 9.81 18 343250 901 110245130
Malignant catatonia 18 9.81 16 343252 690 110245341
Pathogen resistance 17.94 9.81 17 343251 17655 110228376
Neurosis 17.94 9.81 15 343253 595 110245436
Paranoia 17.92 9.81 125 343143 22249 110223782
Brain hypoxia 17.91 9.81 21 343247 1261 110244770
Cellulitis 17.90 9.81 279 342989 125737 110120294
Adrenergic syndrome 17.90 9.81 11 343257 266 110245765
Cerebral haemorrhage 17.86 9.81 123 343145 64845 110181186
Negativism 17.85 9.81 18 343250 911 110245120
Abdominal distension 17.68 9.81 411 342857 174692 110071339
Thermal burns of eye 17.68 9.81 9 343259 149 110245882
Painful ejaculation 17.64 9.81 8 343260 101 110245930
Mouth ulceration 17.63 9.81 83 343185 48055 110197976
Blood triglycerides increased 17.62 9.81 131 343137 23795 110222236
Hypercapnia 17.58 9.81 75 343193 11084 110234947
Respiratory tract infection 17.58 9.81 140 343128 71477 110174554
Laryngeal injury 17.53 9.81 5 343263 13 110246018
Blood osmolarity increased 17.46 9.81 17 343251 824 110245207
Osteonecrosis of jaw 17.46 9.81 83 343185 47934 110198097
Cholangitis 17.44 9.81 15 343253 16320 110229711
Self esteem decreased 17.36 9.81 19 343249 1058 110244973
Acute pulmonary oedema 17.35 9.81 101 343167 16895 110229136
Hyperventilation 17.21 9.81 64 343204 8883 110237148
Hyperacusis 17.18 9.81 32 343236 2920 110243111
Encephalopathy 17.15 9.81 350 342918 80705 110165326
Leukopenia 17.12 9.81 342 342926 148449 110097582
Hepatitis cholestatic 17.04 9.81 103 343165 17463 110228568
Throat irritation 16.99 9.81 97 343171 53455 110192576
Psychiatric symptom 16.97 9.81 65 343203 9148 110236883
Bipolar disorder 16.96 9.81 64 343204 8943 110237088
Graft versus host disease 16.95 9.81 20 343248 18786 110227245
Pneumatosis intestinalis 16.94 9.81 3 343265 8526 110237505
Necrotising colitis 16.93 9.81 24 343244 1741 110244290
Necrosis ischaemic 16.93 9.81 21 343247 1338 110244693
Physical assault 16.91 9.81 23 343245 1605 110244426
Pancreatitis acute 16.89 9.81 272 342996 60002 110186029
Coma scale 16.88 9.81 7 343261 70 110245961
Accident 16.79 9.81 73 343195 10879 110235152
Ligament sprain 16.74 9.81 96 343172 15972 110230059
Swollen tongue 16.73 9.81 114 343154 60248 110185783
Tobacco user 16.67 9.81 16 343252 762 110245269
Bronchopulmonary aspergillosis allergic 16.66 9.81 3 343265 8423 110237608
Cataract 16.58 9.81 162 343106 79323 110166708
Marchiafava-Bignami disease 16.54 9.81 5 343263 17 110246014
Skin abrasion 16.51 9.81 96 343172 16055 110229976
Disability 16.50 9.81 44 343224 30179 110215852
Abnormal dreams 16.50 9.81 81 343187 12699 110233332
Oesophagitis chemical 16.45 9.81 7 343261 75 110245956
Pustular psoriasis 16.43 9.81 11 343257 13594 110232437
Wrong rate 16.43 9.81 9 343259 174 110245857
Therapeutic response decreased 16.43 9.81 206 343062 96293 110149738
Libido decreased 16.39 9.81 48 343220 5887 110240144
Transplant dysfunction 16.39 9.81 3 343265 8325 110237706
Haematotoxicity 16.39 9.81 25 343243 21057 110224974
Biliary dyskinesia 16.35 9.81 28 343240 2393 110243638
Overlap syndrome 16.32 9.81 4 343264 9055 110236976
Oesophageal disorder 16.29 9.81 32 343236 3038 110242993
Muscle spasticity 16.25 9.81 57 343211 35858 110210173
Polyarthritis 16.22 9.81 21 343247 18942 110227089
Oedema peripheral 16.21 9.81 844 342424 327816 109918215
Feeling of relaxation 16.21 9.81 9 343259 179 110245852
Therapeutic response shortened 16.21 9.81 43 343225 29540 110216491
Sarcomatoid carcinoma 16.20 9.81 6 343262 43 110245988
Graft versus host disease in skin 16.19 9.81 3 343265 8251 110237780
Product solubility abnormal 16.18 9.81 19 343249 1143 110244888
Hypophosphataemia 16.15 9.81 51 343217 33131 110212900
Laboratory test abnormal 16.14 9.81 76 343192 44003 110202028
Acquired amegakaryocytic thrombocytopenia 16.08 9.81 6 343262 44 110245987
Euglycaemic diabetic ketoacidosis 16.03 9.81 8 343260 11615 110234416
Clinomania 15.98 9.81 7 343261 81 110245950
Respiratory disorder 15.96 9.81 143 343125 71239 110174792
Electrocardiogram QRS complex shortened 15.96 9.81 16 343252 804 110245227
Faecal disimpaction 15.91 9.81 5 343263 20 110246011
Substance-induced mood disorder 15.90 9.81 7 343261 82 110245949
Gout 15.90 9.81 59 343209 36507 110209524
Creatinine renal clearance decreased 15.89 9.81 27 343241 21788 110224243
Body temperature increased 15.83 9.81 102 343166 54611 110191420
Disinhibition 15.83 9.81 32 343236 3102 110242929
Squamous cell carcinoma of skin 15.83 9.81 18 343250 17185 110228846
Incision site pain 15.83 9.81 32 343236 3103 110242928
Cholecystectomy 15.78 9.81 71 343197 10738 110235293
Nail bed inflammation 15.76 9.81 25 343243 2005 110244026
Hypoventilation 15.70 9.81 58 343210 8023 110238008
Neutropenic colitis 15.67 9.81 3 343265 8062 110237969
Photophobia 15.65 9.81 135 343133 25636 110220395
Tachyphrenia 15.58 9.81 27 343241 2329 110243702
Blood catecholamines increased 15.54 9.81 7 343261 87 110245944
Dyssomnia 15.53 9.81 6 343262 49 110245982
Ear pain 15.52 9.81 99 343169 53127 110192904
Chronic graft versus host disease 15.51 9.81 5 343263 9452 110236579
Bacterial prostatitis 15.47 9.81 7 343261 88 110245943
Stevens-Johnson syndrome 15.39 9.81 84 343184 46817 110199214
Drug screen negative 15.36 9.81 11 343257 346 110245685
Myasthenia gravis 15.33 9.81 27 343241 21484 110224547
Labelled drug-food interaction medication error 15.28 9.81 9 343259 201 110245830
Learning disorder 15.24 9.81 15 343253 737 110245294
Drug screen false positive 15.23 9.81 20 343248 1349 110244682
Immunodeficiency 15.22 9.81 186 343082 38652 110207379
Bone marrow failure 15.18 9.81 111 343157 57737 110188294
Legal problem 15.17 9.81 8 343260 143 110245888
Decreased appetite 15.15 9.81 1271 341997 474575 109771456
Mixed anxiety and depressive disorder 15.12 9.81 14 343254 637 110245394
Pleural effusion 15.04 9.81 428 342840 177281 110068750
Hypervigilance 15.01 9.81 14 343254 643 110245388
Needle issue 15.01 9.81 20 343248 17820 110228211
Nephropathy toxic 15.01 9.81 40 343228 27438 110218593
Lip swelling 14.90 9.81 94 343174 50573 110195458
Gallbladder disorder 14.85 9.81 114 343154 20915 110225116
COVID-19 pneumonia 14.84 9.81 62 343206 37081 110208950
Dermatitis allergic 14.82 9.81 28 343240 21696 110224335
Anion gap 14.80 9.81 24 343244 1961 110244070
Vision blurred 14.77 9.81 514 342754 128508 110117523
Sexual dysfunction 14.75 9.81 59 343209 8471 110237560
Medication error 14.74 9.81 430 342838 104936 110141095
Anamnestic reaction 14.74 9.81 6 343262 57 110245974
Metastases to bone 14.73 9.81 49 343219 31323 110214708
Sinus congestion 14.70 9.81 47 343221 30412 110215619
Gastric polyps 14.62 9.81 44 343224 5479 110240552
Neuropathy peripheral 14.61 9.81 434 342834 178843 110067188
Cerebral haematoma 14.61 9.81 64 343204 9568 110236463
Inflammatory marker increased 14.59 9.81 14 343254 14455 110231576
Hypocalcaemia 14.59 9.81 131 343137 65235 110180796
Growth hormone deficiency 14.59 9.81 12 343256 465 110245566
Haemorrhage 14.56 9.81 238 343030 106454 110139577
Pre-existing condition improved 14.54 9.81 49 343219 6477 110239554
Bone density decreased 14.53 9.81 17 343251 16025 110230006
Sinus arrhythmia 14.52 9.81 25 343243 2145 110243886
Sleep paralysis 14.46 9.81 16 343252 902 110245129
Second primary malignancy 14.46 9.81 21 343247 18047 110227984
Ataxia 14.43 9.81 150 343118 29958 110216073
Hyperinsulinism 14.43 9.81 4 343264 9 110246022
Hypertonia 14.43 9.81 58 343210 8348 110237683
Brugada syndrome 14.37 9.81 21 343247 1567 110244464
Interstitial lung disease 14.36 9.81 326 342942 139008 110107023
Confirmed e-cigarette or vaping product use associated lung injury 14.34 9.81 3 343265 0 110246031
Blood triglycerides abnormal 14.33 9.81 13 343255 576 110245455
Postprandial hypoglycaemia 14.28 9.81 8 343260 162 110245869
Blood triglycerides decreased 14.27 9.81 9 343259 228 110245803
Judgement impaired 14.13 9.81 19 343249 1311 110244720
Maximal voluntary ventilation abnormal 14.12 9.81 5 343263 31 110246000
Blood phosphorus increased 14.07 9.81 18 343250 16322 110229709
Torsade de pointes 14.04 9.81 119 343149 22481 110223550
Cystitis 14.03 9.81 134 343134 65902 110180129
Nodule 13.96 9.81 53 343215 32578 110213453
Respiratory tract congestion 13.94 9.81 49 343219 30808 110215223
Benzodiazepine drug level increased 13.90 9.81 9 343259 239 110245792
Behaviour disorder 13.81 9.81 63 343205 9584 110236447
Lymphadenopathy 13.79 9.81 129 343139 63706 110182325
Cardiac hypertrophy 13.78 9.81 23 343245 1924 110244107
Deep vein thrombosis 13.78 9.81 548 342720 139339 110106692
Pneumonia bacterial 13.77 9.81 39 343229 26222 110219809
Haemolysis 13.71 9.81 17 343251 15622 110230409
Brain injury 13.71 9.81 80 343188 13396 110232635
Nodular rash 13.65 9.81 10 343258 326 110245705
Rhinovirus infection 13.62 9.81 10 343258 11779 110234252
Family stress 13.55 9.81 14 343254 729 110245302
Injection site erythema 13.55 9.81 208 343060 93968 110152063
Social avoidant behaviour 13.49 9.81 42 343226 5327 110240704
Brain death 13.47 9.81 48 343220 6525 110239506
Coagulation factor decreased 13.46 9.81 10 343258 333 110245698
Electroencephalogram abnormal 13.45 9.81 46 343222 6127 110239904
Venous oxygen saturation increased 13.25 9.81 5 343263 38 110245993
Gastric infection 13.25 9.81 36 343232 4230 110241801
Nephrotic syndrome 13.25 9.81 14 343254 13817 110232214
Cyclothymic disorder 13.23 9.81 9 343259 260 110245771
PO2 increased 13.22 9.81 20 343248 1539 110244492
Uterine perforation 13.21 9.81 49 343219 6791 110239240
Vasoplegia syndrome 13.16 9.81 42 343226 5397 110240634
Faecal vomiting 13.15 9.81 20 343248 1546 110244485
Face injury 13.05 9.81 37 343231 4455 110241576
Pulmonary tuberculosis 13.05 9.81 6 343262 9133 110236898
Peripheral nerve paresis 13.03 9.81 5 343263 40 110245991
Blood bilirubin increased 13 9.81 162 343106 75810 110170221
Erythema 12.99 9.81 1062 342206 290385 109955646
Cytomegalovirus colitis 12.95 9.81 3 343265 7058 110238973
Periorbital haematoma 12.94 9.81 16 343252 1016 110245015
Hair texture abnormal 12.92 9.81 34 343234 3920 110242111
Atrioventricular block first degree 12.92 9.81 82 343186 14143 110231888
Vascular purpura 12.91 9.81 33 343235 3738 110242293
Cytopenia 12.83 9.81 49 343219 30067 110215964
Vascular headache 12.82 9.81 5 343263 42 110245989
Hyporeflexia 12.81 9.81 35 343233 4125 110241906
Varicose vein 12.81 9.81 49 343219 6891 110239140
Amimia 12.75 9.81 6 343262 83 110245948
Electrocardiogram T wave amplitude increased 12.75 9.81 6 343262 83 110245948
CSF red blood cell count positive 12.75 9.81 6 343262 83 110245948
Cutaneous lymphoma 12.74 9.81 9 343259 277 110245754
Muscle tightness 12.73 9.81 84 343184 14678 110231353
Tracheobronchitis bacterial 12.73 9.81 4 343264 16 110246015
Traumatic intracranial haematoma 12.72 9.81 5 343263 43 110245988
Enthesopathy 12.67 9.81 12 343256 12466 110233565
Ankylosing spondylitis 12.63 9.81 18 343250 15594 110230437
Nystagmus 12.61 9.81 70 343198 11507 110234524
Spondylitis 12.61 9.81 10 343258 11328 110234703
Localised infection 12.59 9.81 80 343188 42968 110203063
Eschar 12.56 9.81 19 343249 1462 110244569
Treatment noncompliance 12.55 9.81 306 342962 72684 110173347
Language disorder 12.54 9.81 33 343235 3805 110242226
Post-traumatic stress disorder 12.53 9.81 47 343221 6549 110239482
Sickle cell anaemia with crisis 12.53 9.81 7 343261 9538 110236493
Paradoxical drug reaction 12.51 9.81 62 343206 9755 110236276
Vasculitis 12.47 9.81 63 343205 35810 110210221
Dysphemia 12.47 9.81 34 343234 4003 110242028
Urinary incontinence 12.41 9.81 216 343052 48371 110197660
Impulsive behaviour 12.39 9.81 30 343238 3285 110242746
Bundle branch block 12.37 9.81 21 343247 1782 110244249
Hyperdynamic left ventricle 12.36 9.81 12 343256 580 110245451
Syncope 12.31 9.81 757 342511 201779 110044252
Injection site pain 12.29 9.81 440 342828 177482 110068549
Testicular operation 12.26 9.81 3 343265 3 110246028
Pneumonia viral 12.21 9.81 10 343258 11147 110234884
Cushingoid 12.21 9.81 11 343257 11701 110234330
Nocardiosis 12.20 9.81 4 343264 7482 110238549
Liver function test abnormal 12.19 9.81 146 343122 68804 110177227
Brain abscess 12.19 9.81 3 343265 6771 110239260
Hypophonesis 12.18 9.81 4 343264 19 110246012
Angina pectoris 12.16 9.81 129 343139 62166 110183865
Blood creatine phosphokinase increased 12.15 9.81 305 342963 72772 110173259
Skin reaction 12.15 9.81 30 343238 21114 110224917
Labelled drug-drug interaction issue 12.13 9.81 34 343234 4067 110241964
No adverse event 12.06 9.81 159 343109 73680 110172351
Thrombotic microangiopathy 12.05 9.81 48 343220 29101 110216930
Listless 11.98 9.81 36 343232 4479 110241552
Cerebral microangiopathy 11.97 9.81 10 343258 396 110245635
Tubulointerstitial nephritis and uveitis syndrome 11.97 9.81 10 343258 396 110245635
Purpura senile 11.97 9.81 12 343256 603 110245428
Multiple drug therapy 11.97 9.81 53 343215 7961 110238070
Erythrodermic psoriasis 11.96 9.81 22 343246 1988 110244043
Catarrh 11.81 9.81 4 343264 7331 110238700
Back pain 11.80 9.81 1320 341948 369676 109876355
Device related infection 11.78 9.81 73 343195 39446 110206585
Pneumoconiosis 11.78 9.81 9 343259 313 110245718
Posturing 11.77 9.81 16 343252 1116 110244915
Large intestine perforation 11.73 9.81 21 343247 16608 110229423
Amnestic disorder 11.69 9.81 13 343255 737 110245294
Akathisia 11.65 9.81 92 343176 17021 110229010
Injection site swelling 11.64 9.81 129 343139 61661 110184370
Enterococcal infection 11.62 9.81 29 343239 20337 110225694
Gallbladder hypofunction 11.62 9.81 11 343257 515 110245516
Agranulocytosis 11.56 9.81 262 343006 61498 110184533
Pupil fixed 11.53 9.81 32 343236 3806 110242225
Cerebral infarction 11.52 9.81 104 343164 51734 110194297
Anterograde amnesia 11.51 9.81 14 343254 874 110245157
Bladder cancer 11.50 9.81 29 343239 20263 110225768
Sepsis syndrome 11.50 9.81 19 343249 1577 110244454
Arthritis bacterial 11.47 9.81 10 343258 10810 110235221
Phobia 11.45 9.81 10 343258 421 110245610
Suspiciousness 11.45 9.81 13 343255 754 110245277
Tachyphylaxis 11.37 9.81 10 343258 425 110245606
Electrocardiogram ST-T change 11.37 9.81 19 343249 1591 110244440
Distractibility 11.35 9.81 14 343254 887 110245144
Brachial artery entrapment syndrome 11.33 9.81 5 343263 59 110245972
Immune-mediated enterocolitis 11.31 9.81 9 343259 10176 110235855
Libido disorder 11.30 9.81 9 343259 333 110245698
Crime 11.25 9.81 5 343263 60 110245971
Myopia 11.25 9.81 23 343245 2248 110243783
Aplasia pure red cell 11.23 9.81 8 343260 9570 110236461
Skin toxicity 11.20 9.81 12 343256 11771 110234260
Death of relative 11.18 9.81 9 343259 338 110245693
Micturition disorder 11.12 9.81 36 343232 4662 110241369
Varicella zoster virus infection 11.11 9.81 3 343265 6365 110239666
Fistula 11.08 9.81 19 343249 15280 110230751
Intervertebral disc disorder 11.08 9.81 40 343228 5472 110240559
Decreased interest 11.07 9.81 37 343231 4871 110241160
Plasma cell myeloma recurrent 11.07 9.81 4 343264 7038 110238993
Therapeutic response unexpected 11.06 9.81 118 343150 23725 110222306
Tremor neonatal 11.06 9.81 3 343265 6 110246025
Benign mesenteric neoplasm 11.06 9.81 3 343265 6 110246025
Asthma-chronic obstructive pulmonary disease overlap syndrome 11.05 9.81 3 343265 6341 110239690
Daydreaming 11.03 9.81 16 343252 1186 110244845
Acute stress disorder 10.92 9.81 11 343257 556 110245475
Headache 10.92 9.81 2986 340282 879391 109366640
Vagus nerve disorder 10.90 9.81 5 343263 65 110245966
General symptom 10.89 9.81 7 343261 8839 110237192
Tooth discolouration 10.88 9.81 17 343251 1346 110244685
Skin haemorrhage 10.84 9.81 40 343228 24787 110221244
Ventricular hypertrophy 10.83 9.81 47 343221 6998 110239033
Colitis microscopic 10.83 9.81 75 343193 13319 110232712
Flat affect 10.83 9.81 24 343244 2481 110243550
Electrocardiogram repolarisation abnormality 10.81 9.81 23 343245 2312 110243719
Hypersensitivity vasculitis 10.80 9.81 4 343264 6933 110239098
Phonophobia 10.78 9.81 12 343256 681 110245350
Gastric cancer 10.70 9.81 11 343257 10997 110235034
Polyneuropathy 10.69 9.81 57 343211 31955 110214076
Myotonia 10.68 9.81 8 343260 270 110245761
Mood swings 10.63 9.81 113 343155 22699 110223332
Myositis 10.62 9.81 55 343213 31061 110214970
Appetite disorder 10.60 9.81 59 343209 9710 110236321
Anion gap abnormal 10.54 9.81 13 343255 823 110245208
Skin wrinkling 10.54 9.81 18 343250 1535 110244496
Hallucination, olfactory 10.49 9.81 11 343257 583 110245448
Affect lability 10.48 9.81 96 343172 18541 110227490
Persecutory delusion 10.47 9.81 43 343225 6248 110239783
Malaise 10.42 9.81 1881 341387 669938 109576093
Decreased immune responsiveness 10.41 9.81 58 343210 9548 110236483
Prescribed underdose 10.41 9.81 141 343127 65033 110180998
Intrusive thoughts 10.39 9.81 12 343256 709 110245322
Myopathy 10.39 9.81 41 343227 24919 110221112
Streptococcal sepsis 10.36 9.81 37 343231 5035 110240996
Peptic ulcer 10.35 9.81 49 343219 7570 110238461
Strabismus 10.34 9.81 29 343239 3470 110242561
Drop attacks 10.33 9.81 15 343253 1113 110244918
Blood pressure increased 10.31 9.81 677 342591 257696 109988335
Obsessive-compulsive personality disorder 10.31 9.81 6 343262 131 110245900
Faecal calprotectin increased 10.25 9.81 4 343264 6715 110239316
Cardioactive drug level decreased 10.24 9.81 7 343261 204 110245827
Gallbladder injury 10.19 9.81 16 343252 1272 110244759
Colorectal cancer 10.19 9.81 8 343260 9106 110236925
Choking 10.16 9.81 81 343187 15029 110231002
Metabolic acidosis 10.11 9.81 392 342876 99352 110146679
Infective pulmonary exacerbation of cystic fibrosis 10.11 9.81 19 343249 14752 110231279
Wound complication 10.11 9.81 42 343226 6135 110239896
Cerebral disorder 10.08 9.81 45 343223 6781 110239250
Performance status decreased 10.06 9.81 47 343221 7219 110238812
Rales 10.06 9.81 41 343227 24698 110221333
Pneumonitis 10.02 9.81 172 343096 76359 110169672
Mental impairment 10.02 9.81 111 343157 22528 110223503
Proctalgia 9.97 9.81 16 343252 13206 110232825
Benzodiazepine drug level 9.97 9.81 3 343265 10 110246021
Illogical thinking 9.92 9.81 5 343263 81 110245950
Hiatus hernia 9.88 9.81 130 343138 27476 110218555
Persistent depressive disorder 9.86 9.81 17 343251 1460 110244571
Anal abscess 9.84 9.81 13 343255 11625 110234406
Femoral artery aneurysm 9.83 9.81 7 343261 218 110245813

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug withdrawal syndrome neonatal 33.17 28.04 33 225 2397 111298

Pharmacologic Action:

SourceCodeDescription
ATC N05BA12 NERVOUS SYSTEM
PSYCHOLEPTICS
ANXIOLYTICS
Benzodiazepine derivatives
FDA CS M0002356 Benzodiazepines
CHEBI has role CHEBI:35469 antidepressant
CHEBI has role CHEBI:35474 anxiolytic drug
CHEBI has role CHEBI:35476 antipsychotic agent
CHEBI has role CHEBI:35526 hypoglycemic agent
CHEBI has role CHEBI:35623 anticonvulsant
CHEBI has role CHEBI:35703 xenobiotic
CHEBI has role CHEBI:35717 sedative
CHEBI has role CHEBI:51371 muscle relaxant
CHEBI has role CHEBI:51373 GABA agonist
CHEBI has role CHEBI:65023 anti-asthmatic agent
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D006993 Hypnotics and Sedatives
MeSH PA D011619 Psychotropic Drugs
MeSH PA D014151 Anti-Anxiety Agents
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018682 GABA Agents
MeSH PA D018757 GABA Modulators
FDA EPC N0000175694 Benzodiazepine

Related Drugs by ATC class:

N05BA Benzodiazepine derivatives 23 drugs
adinazolambentazepambromazepamcamazepamchlordiazepoxideclobazamclorazepateclotiazepamcloxazolamdiazepamethyl loflazepateetizolam show all 23 →

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Generalized anxiety disorder indication 21897009 DOID:14320
Anxiety indication 48694002
Mixed anxiety and depressive disorder indication 231504006
Panic disorder indication 371631005 DOID:594
Insomnia off-label use 193462001
Suicidal thoughts contraindication 6471006
Asthenia contraindication 13791008
Alcohol intoxication contraindication 25702006
Depressive disorder contraindication 35489007
Substance abuse contraindication 66214007
Sleep apnea contraindication 73430006 DOID:0050847
Open-angle glaucoma contraindication 84494001 DOID:1067
Kidney disease contraindication 90708001 DOID:557
Disease of liver contraindication 235856003 DOID:409
Syncope contraindication 271594007
Pregnancy, function contraindication 289908002
Angle-closure glaucoma contraindication 392291006 DOID:13550
Breastfeeding (mother) contraindication 413712001
Chronic lung disease contraindication 413839001
Obesity contraindication 414916001 DOID:9970
Central nervous system depression contraindication 418072004
Smokes tobacco daily contraindication 449868002




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 6.15 Basic
pKa2 4.9 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
GABA-A receptor alpha-5/beta-3/gamma-2 Ion channel POSITIVE ALLOSTERIC MODULATOR EC50 8 WOMBAT-PK CHEMBL
GABA-A receptor alpha-1/beta-2/gamma-2 Ion channel POSITIVE ALLOSTERIC MODULATOR EC50 7.43 WOMBAT-PK CHEMBL
GABA-A receptor alpha-2/beta-3/gamma-2 Ion channel POSITIVE ALLOSTERIC MODULATOR EC50 7.92 WOMBAT-PK CHEMBL
GABA-A receptor alpha-3/beta-3/gamma-2 Ion channel POSITIVE ALLOSTERIC MODULATOR EC50 7.16 WOMBAT-PK CHEMBL
Cytochrome P450 3A4 Enzyme Ki 3.85 WOMBAT-PK
Platelet-activating factor receptor GPCR Ki 5.46 PDSP
Bromodomain-containing protein 4 Nuclear other Kd 5.61 CHEMBL
Cholecystokinin receptor type A GPCR IC50 4.19 CHEMBL

External reference:

IDSource
D00225 KEGG_DRUG
202363 RXNORM
C0002333 UMLSCUI
CHEBI:2611 CHEBI
08H PDB_CHEM_ID
CHEMBL661 ChEMBL_ID
DB00404 DRUGBANK_ID
D000525 MESH_DESCRIPTOR_UI
2118 PUBCHEM_CID
7111 IUPHAR_LIGAND_ID
3426 INN_ID
YU55MQ3IZY UNII
1327 MMSL
1885 MMSL
4153 MMSL
d00168 MMSL
4018074 VANDF
001464 NDDF
111127002 SNOMEDCT_US
386983007 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Xanax HUMAN PRESCRIPTION DRUG LABEL 1 0009-0029 TABLET 0.25 mg ORAL NDA 33 sections
Xanax HUMAN PRESCRIPTION DRUG LABEL 1 0009-0029 TABLET 0.25 mg ORAL NDA 33 sections
Xanax HUMAN PRESCRIPTION DRUG LABEL 1 0009-0055 TABLET 0.50 mg ORAL NDA 33 sections
Xanax HUMAN PRESCRIPTION DRUG LABEL 1 0009-0055 TABLET 0.50 mg ORAL NDA 33 sections
Xanax HUMAN PRESCRIPTION DRUG LABEL 1 0009-0090 TABLET 1 mg ORAL NDA 33 sections
Xanax HUMAN PRESCRIPTION DRUG LABEL 1 0009-0090 TABLET 1 mg ORAL NDA 33 sections
Xanax HUMAN PRESCRIPTION DRUG LABEL 1 0009-0094 TABLET 2 mg ORAL NDA 33 sections
Xanax HUMAN PRESCRIPTION DRUG LABEL 1 0009-0094 TABLET 2 mg ORAL NDA 33 sections
Alprazolam HUMAN PRESCRIPTION DRUG LABEL 1 0054-3068 SOLUTION, CONCENTRATE 1 mg ORAL ANDA 32 sections
Alprazolam HUMAN PRESCRIPTION DRUG LABEL 1 0228-2027 TABLET 0.25 mg ORAL ANDA 29 sections
Alprazolam HUMAN PRESCRIPTION DRUG LABEL 1 0228-2027 TABLET 0.25 mg ORAL ANDA 29 sections
Alprazolam HUMAN PRESCRIPTION DRUG LABEL 1 0228-2029 TABLET 0.50 mg ORAL ANDA 29 sections
Alprazolam HUMAN PRESCRIPTION DRUG LABEL 1 0228-2029 TABLET 0.50 mg ORAL ANDA 29 sections
Alprazolam HUMAN PRESCRIPTION DRUG LABEL 1 0228-2031 TABLET 1 mg ORAL ANDA 29 sections
Alprazolam HUMAN PRESCRIPTION DRUG LABEL 1 0228-2031 TABLET 1 mg ORAL ANDA 29 sections
Alprazolam HUMAN PRESCRIPTION DRUG LABEL 1 0228-2039 TABLET 2 mg ORAL ANDA 29 sections
Alprazolam HUMAN PRESCRIPTION DRUG LABEL 1 0228-2039 TABLET 2 mg ORAL ANDA 29 sections
AlprazolamExtended Release HUMAN PRESCRIPTION DRUG LABEL 1 0228-3083 TABLET, EXTENDED RELEASE 0.50 mg ORAL ANDA 29 sections
AlprazolamExtended Release HUMAN PRESCRIPTION DRUG LABEL 1 0228-3084 TABLET, EXTENDED RELEASE 1 mg ORAL ANDA 29 sections
AlprazolamExtended Release HUMAN PRESCRIPTION DRUG LABEL 1 0228-3086 TABLET, EXTENDED RELEASE 3 mg ORAL ANDA 29 sections
AlprazolamExtended Release HUMAN PRESCRIPTION DRUG LABEL 1 0228-3087 TABLET, EXTENDED RELEASE 2 mg ORAL ANDA 29 sections
Alprazolam HUMAN PRESCRIPTION DRUG LABEL 1 0228-4019 TABLET, ORALLY DISINTEGRATING 0.25 mg ORAL ANDA 31 sections
Alprazolam HUMAN PRESCRIPTION DRUG LABEL 1 0228-4022 TABLET, ORALLY DISINTEGRATING 0.50 mg ORAL ANDA 31 sections
Alprazolam HUMAN PRESCRIPTION DRUG LABEL 1 0228-4024 TABLET, ORALLY DISINTEGRATING 1 mg ORAL ANDA 31 sections
Alprazolam HUMAN PRESCRIPTION DRUG LABEL 1 0228-4025 TABLET, ORALLY DISINTEGRATING 2 mg ORAL ANDA 31 sections
Alprazolam HUMAN PRESCRIPTION DRUG LABEL 1 0781-1061 TABLET 0.25 mg ORAL ANDA 32 sections
Alprazolam HUMAN PRESCRIPTION DRUG LABEL 1 0781-1077 TABLET 0.50 mg ORAL ANDA 32 sections
Alprazolam HUMAN PRESCRIPTION DRUG LABEL 1 0781-1079 TABLET 1 mg ORAL ANDA 32 sections
Alprazolam HUMAN PRESCRIPTION DRUG LABEL 1 0781-1089 TABLET 2 mg ORAL ANDA 32 sections
Alprazolam HUMAN PRESCRIPTION DRUG LABEL 1 10544-029 TABLET 0.25 mg ORAL ANDA 18 sections