Stem definition | Drug id | CAS RN |
---|---|---|
diazepam derivatives | 136 | 28981-97-7 |
Dose | Unit | Route |
---|---|---|
1 | mg | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 0.07 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 20 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 0.46 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 88 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 0.80 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 0.74 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.29 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 12 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Oct. 16, 1981 | FDA | PHARMACIA AND UPJOHN |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug abuse | 5867.10 | 9.71 | 3586 | 241084 | 68932 | 63175420 |
Completed suicide | 4349.58 | 9.71 | 3954 | 240716 | 141719 | 63102633 |
Sopor | 2268.01 | 9.71 | 1278 | 243392 | 20886 | 63223466 |
Toxicity to various agents | 2023.89 | 9.71 | 3503 | 241167 | 243747 | 63000605 |
Respiratory arrest | 1367.50 | 9.71 | 1079 | 243591 | 31566 | 63212786 |
Suicide attempt | 1248.85 | 9.71 | 1350 | 243320 | 59568 | 63184784 |
Poisoning | 1157.73 | 9.71 | 698 | 243972 | 13002 | 63231350 |
Intentional overdose | 1116.19 | 9.71 | 1402 | 243268 | 72750 | 63171602 |
Cardio-respiratory arrest | 975.34 | 9.71 | 1179 | 243491 | 58780 | 63185572 |
Poisoning deliberate | 895.15 | 9.71 | 551 | 244119 | 10667 | 63233685 |
Coma | 889.98 | 9.71 | 1167 | 243503 | 63197 | 63181155 |
Cardiac arrest | 843.36 | 9.71 | 1378 | 243292 | 91167 | 63153185 |
Drug dependence | 713.01 | 9.71 | 657 | 244013 | 23826 | 63220526 |
Overdose | 696.75 | 9.71 | 1436 | 243234 | 113642 | 63130710 |
Pemphigus | 689.66 | 9.71 | 3 | 244667 | 183723 | 63060629 |
Somnolence | 575.02 | 9.71 | 1752 | 242918 | 176933 | 63067419 |
Hand deformity | 552.12 | 9.71 | 13 | 244657 | 159444 | 63084908 |
Contraindicated product administered | 542.36 | 9.71 | 93 | 244577 | 217555 | 63026797 |
Synovitis | 524.76 | 9.71 | 55 | 244615 | 186863 | 63057489 |
Systemic lupus erythematosus | 523.37 | 9.71 | 88 | 244582 | 208830 | 63035522 |
Intentional product misuse | 486.97 | 9.71 | 856 | 243814 | 60061 | 63184291 |
Intentional self-injury | 480.62 | 9.71 | 543 | 244127 | 25144 | 63219208 |
Glossodynia | 460.02 | 9.71 | 70 | 244600 | 178806 | 63065546 |
Anti-cyclic citrullinated peptide antibody positive | 425.38 | 9.71 | 4 | 244666 | 116208 | 63128144 |
Drug intolerance | 422.68 | 9.71 | 342 | 244328 | 308319 | 62936033 |
Pericarditis | 407.30 | 9.71 | 25 | 244645 | 131554 | 63112798 |
Arthropathy | 405.47 | 9.71 | 199 | 244471 | 234593 | 63009759 |
Joint swelling | 388.54 | 9.71 | 414 | 244256 | 327252 | 62917100 |
Treatment failure | 369.79 | 9.71 | 152 | 244518 | 198891 | 63045461 |
Maternal exposure during pregnancy | 362.90 | 9.71 | 198 | 244472 | 219864 | 63024488 |
Alopecia | 337.67 | 9.71 | 486 | 244184 | 337050 | 62907302 |
Lower respiratory tract infection | 335.06 | 9.71 | 54 | 244616 | 132253 | 63112099 |
Drug ineffective | 323.06 | 9.71 | 2535 | 242135 | 1042230 | 62202122 |
Off label use | 321.18 | 9.71 | 1424 | 243246 | 673038 | 62571314 |
Swelling | 318.51 | 9.71 | 355 | 244315 | 275023 | 62969329 |
Bradyphrenia | 310.06 | 9.71 | 239 | 244431 | 6741 | 63237611 |
Helicobacter infection | 301.73 | 9.71 | 13 | 244657 | 92772 | 63151580 |
Rheumatoid arthritis | 295.93 | 9.71 | 325 | 244345 | 253494 | 62990858 |
Anxiety | 287.44 | 9.71 | 1621 | 243049 | 215920 | 63028432 |
Drug withdrawal syndrome | 286.32 | 9.71 | 433 | 244237 | 26761 | 63217591 |
Infusion related reaction | 285.54 | 9.71 | 315 | 244355 | 245206 | 62999146 |
Discomfort | 284.11 | 9.71 | 145 | 244525 | 167229 | 63077123 |
Suicidal ideation | 275.94 | 9.71 | 688 | 243982 | 61733 | 63182619 |
Wound | 264.58 | 9.71 | 150 | 244520 | 163113 | 63081239 |
Abdominal discomfort | 261.15 | 9.71 | 527 | 244143 | 320358 | 62923994 |
Depression | 258.75 | 9.71 | 1463 | 243207 | 195029 | 63049323 |
Substance abuse | 236.57 | 9.71 | 175 | 244495 | 4632 | 63239720 |
Mydriasis | 229.18 | 9.71 | 256 | 244414 | 11700 | 63232652 |
Folliculitis | 224.88 | 9.71 | 11 | 244659 | 70306 | 63174046 |
Therapeutic product effect decreased | 220.00 | 9.71 | 252 | 244418 | 192935 | 63051417 |
Rheumatoid factor positive | 214.67 | 9.71 | 34 | 244636 | 84372 | 63159980 |
Nasopharyngitis | 211.56 | 9.71 | 412 | 244258 | 253845 | 62990507 |
Drug use disorder | 211.27 | 9.71 | 166 | 244504 | 4818 | 63239534 |
Withdrawal syndrome | 208.51 | 9.71 | 317 | 244353 | 19680 | 63224672 |
Death | 206.65 | 9.71 | 2278 | 242392 | 372103 | 62872249 |
Product use issue | 197.97 | 9.71 | 341 | 244329 | 220179 | 63024173 |
Panic attack | 193.04 | 9.71 | 325 | 244345 | 22006 | 63222346 |
Agitation | 192.80 | 9.71 | 587 | 244083 | 59170 | 63185182 |
Exposure via ingestion | 192.51 | 9.71 | 127 | 244543 | 2782 | 63241570 |
Hypersensitivity | 192.37 | 9.71 | 538 | 244132 | 292147 | 62952205 |
Infection | 189.20 | 9.71 | 373 | 244297 | 228800 | 63015552 |
Hepatic enzyme increased | 187.96 | 9.71 | 306 | 244364 | 202022 | 63042330 |
Arthralgia | 185.12 | 9.71 | 1361 | 243309 | 568349 | 62676003 |
Loss of consciousness | 185.10 | 9.71 | 923 | 243747 | 117198 | 63127154 |
Muscle injury | 178.76 | 9.71 | 21 | 244649 | 65324 | 63179028 |
Sleep disorder due to general medical condition, insomnia type | 174.23 | 9.71 | 6 | 244664 | 52211 | 63192141 |
Macular degeneration | 167.49 | 9.71 | 321 | 244349 | 24055 | 63220297 |
Rash | 159.47 | 9.71 | 1389 | 243281 | 559482 | 62684870 |
Peripheral swelling | 157.39 | 9.71 | 513 | 244157 | 265429 | 62978923 |
Rheumatic fever | 151.15 | 9.71 | 3 | 244667 | 43108 | 63201244 |
Tremor | 151.06 | 9.71 | 949 | 243721 | 131290 | 63113062 |
C-reactive protein abnormal | 148.06 | 9.71 | 7 | 244663 | 46089 | 63198263 |
Prescription form tampering | 146.46 | 9.71 | 62 | 244608 | 516 | 63243836 |
Impaired healing | 140.87 | 9.71 | 113 | 244557 | 102429 | 63141923 |
Victim of chemical submission | 137.92 | 9.71 | 58 | 244612 | 474 | 63243878 |
General physical health deterioration | 137.64 | 9.71 | 363 | 244307 | 201039 | 63043313 |
Blister | 131.44 | 9.71 | 185 | 244485 | 129629 | 63114723 |
Irritable bowel syndrome | 121.99 | 9.71 | 84 | 244586 | 82328 | 63162024 |
Musculoskeletal stiffness | 120.70 | 9.71 | 340 | 244330 | 184278 | 63060074 |
Bradykinesia | 120.48 | 9.71 | 123 | 244547 | 5065 | 63239287 |
Insomnia | 119.50 | 9.71 | 1312 | 243358 | 213940 | 63030412 |
Altered state of consciousness | 118.79 | 9.71 | 285 | 244385 | 24945 | 63219407 |
Disturbance in attention | 113.80 | 9.71 | 365 | 244305 | 37824 | 63206528 |
Gastrointestinal disorder | 108.74 | 9.71 | 213 | 244457 | 131026 | 63113326 |
Fall | 106.60 | 9.71 | 2112 | 242558 | 390222 | 62854130 |
Depressed level of consciousness | 103.57 | 9.71 | 494 | 244176 | 61584 | 63182768 |
Knee arthroplasty | 102.84 | 9.71 | 40 | 244630 | 54166 | 63190186 |
Stomatitis | 102.57 | 9.71 | 240 | 244430 | 138485 | 63105867 |
Hepatocellular injury | 97.86 | 9.71 | 279 | 244391 | 27102 | 63217250 |
Psoriatic arthropathy | 96.08 | 9.71 | 127 | 244543 | 91393 | 63152959 |
Liver injury | 95.98 | 9.71 | 57 | 244613 | 60463 | 63183889 |
Ill-defined disorder | 94.78 | 9.71 | 105 | 244565 | 81650 | 63162702 |
Accidental overdose | 94.75 | 9.71 | 249 | 244421 | 23060 | 63221292 |
Drug screen positive | 93.43 | 9.71 | 91 | 244579 | 3538 | 63240814 |
Hip arthroplasty | 92.32 | 9.71 | 34 | 244636 | 47612 | 63196740 |
Suspected suicide | 92.08 | 9.71 | 120 | 244550 | 6448 | 63237904 |
Feeling abnormal | 91.46 | 9.71 | 924 | 243746 | 147468 | 63096884 |
Sinusitis | 90.95 | 9.71 | 507 | 244163 | 226146 | 63018206 |
Miosis | 90.36 | 9.71 | 126 | 244544 | 7227 | 63237125 |
Alcohol abuse | 89.93 | 9.71 | 71 | 244599 | 2075 | 63242277 |
Nervousness | 88.61 | 9.71 | 292 | 244378 | 30687 | 63213665 |
Crying | 88.48 | 9.71 | 243 | 244427 | 23100 | 63221252 |
C-reactive protein increased | 86.23 | 9.71 | 145 | 244525 | 94562 | 63149790 |
Intentional product use issue | 83.21 | 9.71 | 236 | 244434 | 127656 | 63116696 |
Disorientation | 82.55 | 9.71 | 336 | 244334 | 39116 | 63205236 |
Drug abuser | 80.36 | 9.71 | 76 | 244594 | 2847 | 63241505 |
Mobility decreased | 77.77 | 9.71 | 225 | 244445 | 120934 | 63123418 |
Hypokinesia | 76.19 | 9.71 | 167 | 244503 | 13769 | 63230583 |
Drug interaction | 75.61 | 9.71 | 1272 | 243398 | 227859 | 63016493 |
Memory impairment | 74.55 | 9.71 | 670 | 244000 | 103588 | 63140764 |
Hallucinations, mixed | 73.65 | 9.71 | 92 | 244578 | 4737 | 63239615 |
Myelosuppression | 71.83 | 9.71 | 5 | 244665 | 23698 | 63220654 |
Drug hypersensitivity | 70.68 | 9.71 | 811 | 243859 | 309876 | 62934476 |
Hallucination, auditory | 70.48 | 9.71 | 154 | 244516 | 12670 | 63231682 |
Febrile neutropenia | 70.31 | 9.71 | 228 | 244442 | 118221 | 63126131 |
Condition aggravated | 70.12 | 9.71 | 1109 | 243561 | 401108 | 62843244 |
Product use in unapproved indication | 69.97 | 9.71 | 404 | 244266 | 178676 | 63065676 |
Abnormal behaviour | 69.57 | 9.71 | 211 | 244459 | 21215 | 63223137 |
Dependence | 68.87 | 9.71 | 60 | 244610 | 2017 | 63242335 |
Wheezing | 67.78 | 9.71 | 169 | 244501 | 95426 | 63148926 |
Vertigo | 65.37 | 9.71 | 425 | 244245 | 59462 | 63184890 |
Irritability | 64.78 | 9.71 | 268 | 244402 | 31426 | 63212926 |
Confusional state | 64.56 | 9.71 | 1274 | 243396 | 235106 | 63009246 |
Aggression | 63.23 | 9.71 | 217 | 244453 | 23281 | 63221071 |
Pyrexia | 63.03 | 9.71 | 1358 | 243312 | 469120 | 62775232 |
Therapeutic product effect incomplete | 62.83 | 9.71 | 258 | 244412 | 124798 | 63119554 |
Urinary retention | 62.55 | 9.71 | 257 | 244413 | 30044 | 63214308 |
Exposure during pregnancy | 62.33 | 9.71 | 348 | 244322 | 155199 | 63089153 |
Therapy non-responder | 62.15 | 9.71 | 124 | 244546 | 75777 | 63168575 |
Psychomotor skills impaired | 62.13 | 9.71 | 60 | 244610 | 2308 | 63242044 |
Psychomotor hyperactivity | 61.99 | 9.71 | 131 | 244539 | 10532 | 63233820 |
Bradypnoea | 61.26 | 9.71 | 72 | 244598 | 3478 | 63240874 |
Cough | 60.92 | 9.71 | 779 | 243891 | 291964 | 62952388 |
Hyponatraemia | 60.15 | 9.71 | 678 | 243992 | 111222 | 63133130 |
Live birth | 59.42 | 9.71 | 13 | 244657 | 25617 | 63218735 |
Respiratory depression | 59.34 | 9.71 | 150 | 244520 | 13565 | 63230787 |
Pain | 59.18 | 9.71 | 2296 | 242374 | 738332 | 62506020 |
Drug resistance | 58.83 | 9.71 | 9 | 244661 | 22924 | 63221428 |
Adverse drug reaction | 58.82 | 9.71 | 138 | 244532 | 79576 | 63164776 |
Anhedonia | 58.29 | 9.71 | 130 | 244540 | 10844 | 63233508 |
Homicide | 52.82 | 9.71 | 27 | 244643 | 358 | 63243994 |
Serotonin syndrome | 52.82 | 9.71 | 235 | 244435 | 28447 | 63215905 |
Euphoric mood | 51.69 | 9.71 | 78 | 244592 | 4809 | 63239543 |
Mental disorder | 51.28 | 9.71 | 217 | 244453 | 25702 | 63218650 |
Hyperhidrosis | 50.74 | 9.71 | 637 | 244033 | 107199 | 63137153 |
Electrocardiogram QT prolonged | 50.74 | 9.71 | 398 | 244272 | 59132 | 63185220 |
Emotional distress | 50.68 | 9.71 | 254 | 244416 | 32295 | 63212057 |
Bone erosion | 50.21 | 9.71 | 5 | 244665 | 17712 | 63226640 |
Type 2 diabetes mellitus | 50.04 | 9.71 | 107 | 244563 | 63761 | 63180591 |
Blood cholesterol increased | 49.76 | 9.71 | 190 | 244480 | 93842 | 63150510 |
Pneumonia | 49.48 | 9.71 | 1361 | 243309 | 455406 | 62788946 |
Abnormal dreams | 48.65 | 9.71 | 118 | 244552 | 10398 | 63233954 |
Hypotension | 48.58 | 9.71 | 1385 | 243285 | 271219 | 62973133 |
Speech disorder | 48.48 | 9.71 | 295 | 244375 | 40334 | 63204018 |
Substance use disorder | 48.48 | 9.71 | 21 | 244649 | 186 | 63244166 |
Grip strength decreased | 48.35 | 9.71 | 13 | 244657 | 22274 | 63222078 |
Respiratory acidosis | 48.06 | 9.71 | 90 | 244580 | 6625 | 63237727 |
Wrong patient received product | 47.08 | 9.71 | 50 | 244620 | 2157 | 63242195 |
Thinking abnormal | 45.63 | 9.71 | 116 | 244554 | 10527 | 63233825 |
Malignant neoplasm progression | 44.71 | 9.71 | 164 | 244506 | 81957 | 63162395 |
Anger | 44.58 | 9.71 | 127 | 244543 | 12329 | 63232023 |
Premature delivery | 43.31 | 9.71 | 32 | 244638 | 30249 | 63214103 |
Neutropenic sepsis | 43.21 | 9.71 | 6 | 244664 | 16432 | 63227920 |
Mania | 43.20 | 9.71 | 125 | 244545 | 12242 | 63232110 |
COVID-19 | 42.64 | 9.71 | 258 | 244412 | 112845 | 63131507 |
Nightmare | 42.17 | 9.71 | 166 | 244504 | 19028 | 63225324 |
Thermal burn | 41.99 | 9.71 | 80 | 244590 | 5966 | 63238386 |
Alcohol poisoning | 41.87 | 9.71 | 44 | 244626 | 1875 | 63242477 |
Delirium | 41.48 | 9.71 | 335 | 244335 | 50206 | 63194146 |
Suicidal behaviour | 41.41 | 9.71 | 51 | 244619 | 2588 | 63241764 |
Dysarthria | 41.18 | 9.71 | 294 | 244376 | 42417 | 63201935 |
Amnesia | 41.15 | 9.71 | 360 | 244310 | 55225 | 63189127 |
Bradycardia | 40.85 | 9.71 | 447 | 244223 | 72780 | 63171572 |
Fatigue | 40.62 | 9.71 | 2912 | 241758 | 885116 | 62359236 |
Anticholinergic syndrome | 40.59 | 9.71 | 48 | 244622 | 2334 | 63242018 |
Product complaint | 40.52 | 9.71 | 125 | 244545 | 12684 | 63231668 |
Hallucination | 40.05 | 9.71 | 354 | 244316 | 54463 | 63189889 |
Head injury | 40.01 | 9.71 | 210 | 244460 | 27186 | 63217166 |
Blood pressure diastolic decreased | 39.50 | 9.71 | 19 | 244651 | 22687 | 63221665 |
Obsessive-compulsive disorder | 39.02 | 9.71 | 62 | 244608 | 3998 | 63240354 |
Dysphoria | 38.63 | 9.71 | 69 | 244601 | 4897 | 63239455 |
Neutrophil count decreased | 38.22 | 9.71 | 102 | 244568 | 56304 | 63188048 |
Mucosal inflammation | 38.12 | 9.71 | 77 | 244593 | 46851 | 63197501 |
Hallucination, visual | 37.74 | 9.71 | 161 | 244509 | 19137 | 63225215 |
Neutropenia | 36.25 | 9.71 | 466 | 244204 | 174539 | 63069813 |
Rhabdomyolysis | 35.90 | 9.71 | 291 | 244379 | 43660 | 63200692 |
Psychomotor retardation | 35.69 | 9.71 | 58 | 244612 | 3812 | 63240540 |
Compartment syndrome | 35.61 | 9.71 | 44 | 244626 | 2240 | 63242112 |
Foot deformity | 35.43 | 9.71 | 33 | 244637 | 27820 | 63216532 |
Renal impairment | 35.20 | 9.71 | 198 | 244472 | 88157 | 63156195 |
Cholecystitis chronic | 34.54 | 9.71 | 103 | 244567 | 10258 | 63234094 |
Urticaria | 34.52 | 9.71 | 441 | 244229 | 165361 | 63078991 |
Sedation | 34.48 | 9.71 | 262 | 244408 | 38547 | 63205805 |
Fear | 34.35 | 9.71 | 136 | 244534 | 15630 | 63228722 |
Impaired driving ability | 34.23 | 9.71 | 62 | 244608 | 4449 | 63239903 |
Bronchiectasis | 33.93 | 9.71 | 10 | 244660 | 16132 | 63228220 |
Housebound | 33.83 | 9.71 | 17 | 244653 | 217 | 63244135 |
Multiple injuries | 33.60 | 9.71 | 38 | 244632 | 1760 | 63242592 |
Blood pressure systolic increased | 33.43 | 9.71 | 84 | 244586 | 47313 | 63197039 |
Dyspnoea | 32.91 | 9.71 | 2152 | 242518 | 659161 | 62585191 |
Cytomegalovirus infection | 32.84 | 9.71 | 20 | 244650 | 20932 | 63223420 |
Stupor | 32.75 | 9.71 | 59 | 244611 | 4216 | 63240136 |
Parkinsonism | 32.21 | 9.71 | 101 | 244569 | 10338 | 63234014 |
Immobilisation prolonged | 31.81 | 9.71 | 13 | 244657 | 98 | 63244254 |
Feeling of despair | 31.65 | 9.71 | 42 | 244628 | 2297 | 63242055 |
Osmolar gap increased | 31.59 | 9.71 | 13 | 244657 | 100 | 63244252 |
Renal papillary necrosis | 31.18 | 9.71 | 17 | 244653 | 259 | 63244093 |
Sluggishness | 30.94 | 9.71 | 65 | 244605 | 5204 | 63239148 |
Chemical submission | 30.84 | 9.71 | 17 | 244653 | 265 | 63244087 |
Persistent genital arousal disorder | 30.61 | 9.71 | 17 | 244653 | 269 | 63244083 |
Osteoarthritis | 30.19 | 9.71 | 229 | 244441 | 95114 | 63149238 |
Blood pressure fluctuation | 29.71 | 9.71 | 86 | 244584 | 46231 | 63198121 |
Lupus-like syndrome | 29.48 | 9.71 | 11 | 244659 | 15284 | 63229068 |
Seizure | 29.46 | 9.71 | 694 | 243976 | 131940 | 63112412 |
Red blood cell sedimentation rate increased | 29.45 | 9.71 | 80 | 244590 | 43902 | 63200450 |
Obstructive airways disorder | 29.44 | 9.71 | 22 | 244648 | 20677 | 63223675 |
Adverse event | 29.35 | 9.71 | 147 | 244523 | 67412 | 63176940 |
Breast cancer stage III | 29.26 | 9.71 | 3 | 244667 | 10383 | 63233969 |
Panic disorder | 29.24 | 9.71 | 43 | 244627 | 2590 | 63241762 |
Cholestasis | 29.18 | 9.71 | 204 | 244466 | 29230 | 63215122 |
Accidental death | 29.11 | 9.71 | 37 | 244633 | 1939 | 63242413 |
Inadequate analgesia | 28.36 | 9.71 | 45 | 244625 | 2898 | 63241454 |
Major depression | 27.97 | 9.71 | 81 | 244589 | 7937 | 63236415 |
Restlessness | 27.96 | 9.71 | 202 | 244468 | 29251 | 63215101 |
Adjustment disorder with mixed anxiety and depressed mood | 27.54 | 9.71 | 12 | 244658 | 108 | 63244244 |
Apraxia | 26.67 | 9.71 | 34 | 244636 | 1787 | 63242565 |
Multiple sclerosis relapse | 26.61 | 9.71 | 295 | 244375 | 48183 | 63196169 |
Cardiogenic shock | 26.56 | 9.71 | 138 | 244532 | 17794 | 63226558 |
Pruritus | 26.48 | 9.71 | 1131 | 243539 | 360322 | 62884030 |
Anaphylactic reaction | 26.39 | 9.71 | 148 | 244522 | 65952 | 63178400 |
Inflammation | 26.34 | 9.71 | 197 | 244473 | 82076 | 63162276 |
Sinus tachycardia | 26.33 | 9.71 | 172 | 244498 | 24096 | 63220256 |
Toxicologic test abnormal | 26.30 | 9.71 | 22 | 244648 | 699 | 63243653 |
Disinhibition | 26.29 | 9.71 | 24 | 244646 | 859 | 63243493 |
Pregnancy | 26.20 | 9.71 | 65 | 244605 | 36771 | 63207581 |
Extrapyramidal disorder | 26.11 | 9.71 | 111 | 244559 | 13173 | 63231179 |
Self-injurious ideation | 26.10 | 9.71 | 41 | 244629 | 2618 | 63241734 |
Mental status changes | 26.03 | 9.71 | 250 | 244420 | 39349 | 63205003 |
Multiple sclerosis | 26.00 | 9.71 | 172 | 244498 | 24200 | 63220152 |
Sepsis | 26.00 | 9.71 | 424 | 244246 | 152699 | 63091653 |
Poverty of speech | 25.88 | 9.71 | 16 | 244654 | 312 | 63244040 |
Arthritis | 25.75 | 9.71 | 304 | 244366 | 115617 | 63128735 |
Inappropriate antidiuretic hormone secretion | 25.74 | 9.71 | 123 | 244547 | 15339 | 63229013 |
Suspected counterfeit product | 25.70 | 9.71 | 17 | 244653 | 374 | 63243978 |
Incoherent | 25.58 | 9.71 | 55 | 244615 | 4475 | 63239877 |
Bipolar I disorder | 25.54 | 9.71 | 34 | 244636 | 1865 | 63242487 |
Device expulsion | 25.32 | 9.71 | 61 | 244609 | 34861 | 63209491 |
Unresponsive to stimuli | 25.02 | 9.71 | 219 | 244451 | 33597 | 63210755 |
Stress | 24.77 | 9.71 | 380 | 244290 | 66787 | 63177565 |
Post-traumatic stress disorder | 24.37 | 9.71 | 59 | 244611 | 5192 | 63239160 |
Hypotonia | 24.33 | 9.71 | 85 | 244585 | 9200 | 63235152 |
Wound infection | 24.26 | 9.71 | 28 | 244642 | 21382 | 63222970 |
Hyponatraemic encephalopathy | 24.12 | 9.71 | 14 | 244656 | 242 | 63244110 |
Depressed mood | 24.12 | 9.71 | 249 | 244421 | 39942 | 63204410 |
Logorrhoea | 23.67 | 9.71 | 38 | 244632 | 2472 | 63241880 |
Disease progression | 23.55 | 9.71 | 332 | 244338 | 122426 | 63121926 |
Asthenia | 23.55 | 9.71 | 1749 | 242921 | 381855 | 62862497 |
Cyanosis | 23.49 | 9.71 | 128 | 244542 | 16807 | 63227545 |
Apathy | 23.47 | 9.71 | 81 | 244589 | 8713 | 63235639 |
Drug-induced liver injury | 23.45 | 9.71 | 78 | 244592 | 40144 | 63204208 |
Emotional disorder | 23.42 | 9.71 | 108 | 244562 | 13271 | 63231081 |
Hypersomnia | 23.41 | 9.71 | 134 | 244536 | 17921 | 63226431 |
Hypothermia | 23.31 | 9.71 | 109 | 244561 | 13472 | 63230880 |
Substance use | 23.31 | 9.71 | 18 | 244652 | 509 | 63243843 |
Liver function test increased | 23.25 | 9.71 | 58 | 244612 | 32753 | 63211599 |
Fibromyalgia | 23.23 | 9.71 | 198 | 244472 | 80222 | 63164130 |
Drug detoxification | 23.20 | 9.71 | 15 | 244655 | 317 | 63244035 |
Alcohol use | 23.16 | 9.71 | 34 | 244636 | 2045 | 63242307 |
Sleep disorder due to a general medical condition | 23.10 | 9.71 | 9 | 244661 | 12179 | 63232173 |
Generalised tonic-clonic seizure | 23.09 | 9.71 | 191 | 244479 | 28825 | 63215527 |
Necrosis ischaemic | 22.96 | 9.71 | 22 | 244648 | 838 | 63243514 |
Benzodiazepine drug level abnormal | 22.81 | 9.71 | 5 | 244665 | 0 | 63244352 |
Bipolar disorder | 22.73 | 9.71 | 75 | 244595 | 7885 | 63236467 |
Liver disorder | 22.65 | 9.71 | 118 | 244552 | 53569 | 63190783 |
Hallucination, gustatory | 22.47 | 9.71 | 9 | 244661 | 64 | 63244288 |
Pancytopenia | 22.39 | 9.71 | 252 | 244418 | 96681 | 63147671 |
Initial insomnia | 22.25 | 9.71 | 63 | 244607 | 6094 | 63238258 |
Transplant rejection | 22.08 | 9.71 | 7 | 244663 | 10773 | 63233579 |
Adjustment disorder with depressed mood | 22.05 | 9.71 | 6 | 244664 | 10198 | 63234154 |
Drug withdrawal syndrome neonatal | 21.70 | 9.71 | 33 | 244637 | 2048 | 63242304 |
Procedural pain | 21.68 | 9.71 | 150 | 244520 | 21419 | 63222933 |
Metastases to liver | 21.68 | 9.71 | 36 | 244634 | 23603 | 63220749 |
Panic reaction | 21.67 | 9.71 | 49 | 244621 | 4125 | 63240227 |
Gun shot wound | 21.51 | 9.71 | 11 | 244659 | 146 | 63244206 |
Drug withdrawal convulsions | 21.49 | 9.71 | 27 | 244643 | 1398 | 63242954 |
Obsessive thoughts | 21.49 | 9.71 | 18 | 244652 | 573 | 63243779 |
Tonic clonic movements | 21.34 | 9.71 | 27 | 244643 | 1408 | 63242944 |
Somnambulism | 21.30 | 9.71 | 58 | 244612 | 5485 | 63238867 |
Lip dry | 21.29 | 9.71 | 17 | 244653 | 15453 | 63228899 |
Blood pressure diastolic abnormal | 21.27 | 9.71 | 15 | 244655 | 14527 | 63229825 |
Joint stiffness | 21.25 | 9.71 | 86 | 244584 | 41783 | 63202569 |
Affect lability | 21.01 | 9.71 | 92 | 244578 | 11059 | 63233293 |
Neuroleptic malignant syndrome | 20.87 | 9.71 | 97 | 244573 | 11959 | 63232393 |
Electrocardiogram QRS complex prolonged | 20.72 | 9.71 | 60 | 244610 | 5878 | 63238474 |
Dysuria | 20.71 | 9.71 | 210 | 244460 | 33528 | 63210824 |
Developmental delay | 20.64 | 9.71 | 27 | 244643 | 1456 | 63242896 |
Pupillary disorder | 20.35 | 9.71 | 12 | 244658 | 214 | 63244138 |
Joint range of motion decreased | 20.23 | 9.71 | 61 | 244609 | 32367 | 63211985 |
Mood altered | 20.16 | 9.71 | 111 | 244559 | 14632 | 63229720 |
Herpes zoster | 19.99 | 9.71 | 212 | 244458 | 82250 | 63162102 |
Aplastic anaemia | 19.98 | 9.71 | 6 | 244664 | 9563 | 63234789 |
Torsade de pointes | 19.95 | 9.71 | 103 | 244567 | 13248 | 63231104 |
Tarsal tunnel syndrome | 19.88 | 9.71 | 17 | 244653 | 557 | 63243795 |
Facet joint syndrome | 19.86 | 9.71 | 11 | 244659 | 12127 | 63232225 |
Hyperreflexia | 19.79 | 9.71 | 59 | 244611 | 5875 | 63238477 |
Body temperature increased | 19.76 | 9.71 | 75 | 244595 | 37117 | 63207235 |
Prescription drug used without a prescription | 19.66 | 9.71 | 34 | 244636 | 2352 | 63242000 |
Uveitis | 19.65 | 9.71 | 12 | 244658 | 12541 | 63231811 |
Blood pressure diastolic increased | 19.63 | 9.71 | 7 | 244663 | 10003 | 63234349 |
Tension | 19.62 | 9.71 | 40 | 244630 | 3135 | 63241217 |
Delusion | 19.57 | 9.71 | 95 | 244575 | 11922 | 63232430 |
Neurotoxicity | 19.49 | 9.71 | 22 | 244648 | 16968 | 63227384 |
Muscle spasms | 19.48 | 9.71 | 761 | 243909 | 155389 | 63088963 |
Cutaneous T-cell dyscrasia | 19.39 | 9.71 | 8 | 244662 | 62 | 63244290 |
Partner stress | 19.28 | 9.71 | 15 | 244655 | 429 | 63243923 |
Hypoglycaemia | 19.24 | 9.71 | 332 | 244338 | 59733 | 63184619 |
Femur fracture | 19.22 | 9.71 | 89 | 244581 | 41667 | 63202685 |
Ataxia | 19.19 | 9.71 | 112 | 244558 | 15083 | 63229269 |
Blood lactic acid | 19.16 | 9.71 | 9 | 244661 | 98 | 63244254 |
Asthma | 19.16 | 9.71 | 361 | 244309 | 127200 | 63117152 |
Acquired amegakaryocytic thrombocytopenia | 19.13 | 9.71 | 6 | 244664 | 18 | 63244334 |
X-ray abnormal | 19.03 | 9.71 | 4 | 244666 | 8106 | 63236246 |
Cardiac failure | 18.95 | 9.71 | 236 | 244434 | 88906 | 63155446 |
Peripheral venous disease | 18.91 | 9.71 | 19 | 244651 | 15458 | 63228894 |
Full blood count abnormal | 18.84 | 9.71 | 61 | 244609 | 31656 | 63212696 |
Substance dependence | 18.81 | 9.71 | 11 | 244659 | 193 | 63244159 |
Face injury | 18.71 | 9.71 | 40 | 244630 | 3242 | 63241110 |
Morbid thoughts | 18.68 | 9.71 | 17 | 244653 | 606 | 63243746 |
Pain in extremity | 18.65 | 9.71 | 1066 | 243604 | 330420 | 62913932 |
Leukopenia | 18.62 | 9.71 | 199 | 244471 | 77091 | 63167261 |
Chronic sinusitis | 18.45 | 9.71 | 98 | 244572 | 12745 | 63231607 |
Hypochloraemia | 18.38 | 9.71 | 30 | 244640 | 1979 | 63242373 |
Product substitution issue | 18.36 | 9.71 | 115 | 244555 | 15881 | 63228471 |
Haemophagocytic lymphohistiocytosis | 18.32 | 9.71 | 9 | 244661 | 10618 | 63233734 |
Vision blurred | 18.31 | 9.71 | 474 | 244196 | 91450 | 63152902 |
Persecutory delusion | 18.26 | 9.71 | 36 | 244634 | 2754 | 63241598 |
Medication error | 18.22 | 9.71 | 293 | 244377 | 51991 | 63192361 |
Theft | 18.17 | 9.71 | 8 | 244662 | 74 | 63244278 |
Chronic obstructive pulmonary disease | 18.14 | 9.71 | 341 | 244329 | 62345 | 63182007 |
Laryngeal injury | 18.07 | 9.71 | 5 | 244665 | 8 | 63244344 |
Bundle branch block right | 17.92 | 9.71 | 51 | 244619 | 4947 | 63239405 |
Cardiac valve disease | 17.87 | 9.71 | 46 | 244624 | 4206 | 63240146 |
Purging | 17.82 | 9.71 | 7 | 244663 | 47 | 63244305 |
Alcoholism | 17.80 | 9.71 | 28 | 244642 | 1790 | 63242562 |
Creatinine renal clearance decreased | 17.76 | 9.71 | 22 | 244648 | 16286 | 63228066 |
Feeling jittery | 17.72 | 9.71 | 100 | 244570 | 13303 | 63231049 |
Formication | 17.60 | 9.71 | 46 | 244624 | 4245 | 63240107 |
Mental disability | 17.54 | 9.71 | 8 | 244662 | 81 | 63244271 |
Drug screen negative | 17.38 | 9.71 | 12 | 244658 | 284 | 63244068 |
Diarrhoea | 17.35 | 9.71 | 2455 | 242215 | 712911 | 62531441 |
Maternal exposure before pregnancy | 17.34 | 9.71 | 4 | 244666 | 7599 | 63236753 |
Sarcomatoid carcinoma | 17.25 | 9.71 | 6 | 244664 | 27 | 63244325 |
Pneumocystis jirovecii pneumonia | 17.21 | 9.71 | 24 | 244646 | 16890 | 63227462 |
Blood bilirubin increased | 17.19 | 9.71 | 79 | 244591 | 37061 | 63207291 |
Slow speech | 17.02 | 9.71 | 25 | 244645 | 1504 | 63242848 |
Dermatitis allergic | 16.96 | 9.71 | 20 | 244650 | 15128 | 63229224 |
Counterfeit product administered | 16.91 | 9.71 | 6 | 244664 | 29 | 63244323 |
Autoimmune disorder | 16.86 | 9.71 | 25 | 244645 | 17152 | 63227200 |
Body temperature decreased | 16.79 | 9.71 | 33 | 244637 | 20286 | 63224066 |
Tenosynovitis | 16.78 | 9.71 | 17 | 244653 | 13778 | 63230574 |
Foetal death | 16.61 | 9.71 | 85 | 244585 | 10895 | 63233457 |
Graft versus host disease | 16.58 | 9.71 | 3 | 244667 | 6760 | 63237592 |
Burn oesophageal | 16.54 | 9.71 | 10 | 244660 | 187 | 63244165 |
Pneumonia streptococcal | 16.51 | 9.71 | 27 | 244643 | 1784 | 63242568 |
Product quality issue | 16.49 | 9.71 | 211 | 244459 | 35654 | 63208698 |
Electrocardiogram QRS complex shortened | 16.47 | 9.71 | 14 | 244656 | 455 | 63243897 |
Tumour lysis syndrome | 16.45 | 9.71 | 7 | 244663 | 8983 | 63235369 |
Diffuse large B-cell lymphoma | 16.40 | 9.71 | 3 | 244667 | 6709 | 63237643 |
Deep vein thrombosis | 16.37 | 9.71 | 431 | 244239 | 83369 | 63160983 |
Pulmonary toxicity | 16.31 | 9.71 | 8 | 244662 | 9447 | 63234905 |
Gambling disorder | 16.21 | 9.71 | 22 | 244648 | 1230 | 63243122 |
Nodular rash | 16.17 | 9.71 | 10 | 244660 | 195 | 63244157 |
Product physical issue | 16.12 | 9.71 | 49 | 244621 | 4931 | 63239421 |
Blood test abnormal | 16.08 | 9.71 | 22 | 244648 | 15607 | 63228745 |
Abortion spontaneous | 16.08 | 9.71 | 111 | 244559 | 47084 | 63197268 |
Gallbladder disorder | 16.06 | 9.71 | 126 | 244544 | 18716 | 63225636 |
Poor venous access | 16.04 | 9.71 | 20 | 244650 | 14765 | 63229587 |
Cardio-respiratory arrest neonatal | 16.02 | 9.71 | 4 | 244666 | 3 | 63244349 |
Muscle rigidity | 16.01 | 9.71 | 87 | 244583 | 11413 | 63232939 |
Contusion | 15.95 | 9.71 | 448 | 244222 | 149596 | 63094756 |
Productive cough | 15.94 | 9.71 | 161 | 244509 | 63047 | 63181305 |
Dyskinesia | 15.89 | 9.71 | 191 | 244479 | 31811 | 63212541 |
Fear of injection | 15.88 | 9.71 | 4 | 244666 | 7160 | 63237192 |
Tubulointerstitial nephritis | 15.87 | 9.71 | 33 | 244637 | 19870 | 63224482 |
Anion gap increased | 15.74 | 9.71 | 27 | 244643 | 1855 | 63242497 |
Oesophageal food impaction | 15.65 | 9.71 | 10 | 244660 | 207 | 63244145 |
Toxic skin eruption | 15.65 | 9.71 | 94 | 244576 | 12791 | 63231561 |
Bone density decreased | 15.61 | 9.71 | 20 | 244650 | 14592 | 63229760 |
Therapy partial responder | 15.58 | 9.71 | 11 | 244659 | 10647 | 63233705 |
Platelet count decreased | 15.53 | 9.71 | 335 | 244335 | 115787 | 63128565 |
Areflexia | 15.52 | 9.71 | 36 | 244634 | 3082 | 63241270 |
Victim of sexual abuse | 15.49 | 9.71 | 16 | 244654 | 668 | 63243684 |
Obsessive-compulsive personality disorder | 15.47 | 9.71 | 5 | 244665 | 17 | 63244335 |
Hepatic function abnormal | 15.46 | 9.71 | 82 | 244588 | 37060 | 63207292 |
Alkalosis hypochloraemic | 15.39 | 9.71 | 9 | 244661 | 158 | 63244194 |
Death of relative | 15.24 | 9.71 | 11 | 244659 | 280 | 63244072 |
Encephalopathy | 15.21 | 9.71 | 221 | 244449 | 38399 | 63205953 |
Metastases to bone | 15.01 | 9.71 | 37 | 244633 | 20982 | 63223370 |
Faecal vomiting | 14.91 | 9.71 | 15 | 244655 | 607 | 63243745 |
Constipation | 14.87 | 9.71 | 1032 | 243638 | 223911 | 63020441 |
Coma scale | 14.82 | 9.71 | 6 | 244664 | 44 | 63244308 |
Pre-existing condition improved | 14.77 | 9.71 | 67 | 244603 | 8177 | 63236175 |
Pancreatitis acute | 14.76 | 9.71 | 165 | 244505 | 27001 | 63217351 |
Joint effusion | 14.72 | 9.71 | 27 | 244643 | 17033 | 63227319 |
Septic shock | 14.69 | 9.71 | 175 | 244495 | 66454 | 63177898 |
Sedation complication | 14.68 | 9.71 | 19 | 244651 | 13803 | 63230549 |
Therapeutic response unexpected | 14.67 | 9.71 | 123 | 244547 | 18636 | 63225716 |
Blood creatinine increased | 14.65 | 9.71 | 244 | 244426 | 87600 | 63156752 |
Lethargy | 14.63 | 9.71 | 300 | 244370 | 55707 | 63188645 |
Respiratory rate decreased | 14.61 | 9.71 | 38 | 244632 | 3497 | 63240855 |
Road traffic accident | 14.58 | 9.71 | 210 | 244460 | 36422 | 63207930 |
Tubulointerstitial nephritis and uveitis syndrome | 14.55 | 9.71 | 10 | 244660 | 235 | 63244117 |
Injection site erythema | 14.55 | 9.71 | 229 | 244441 | 82945 | 63161407 |
Disorganised speech | 14.54 | 9.71 | 21 | 244649 | 1244 | 63243108 |
Vascular headache | 14.49 | 9.71 | 6 | 244664 | 47 | 63244305 |
Homicidal ideation | 14.48 | 9.71 | 25 | 244645 | 1727 | 63242625 |
Normal newborn | 14.48 | 9.71 | 7 | 244663 | 8334 | 63236018 |
Paraesthesia oral | 14.39 | 9.71 | 125 | 244545 | 19131 | 63225221 |
Conversion disorder | 14.36 | 9.71 | 25 | 244645 | 1739 | 63242613 |
Oesophageal achalasia | 14.06 | 9.71 | 13 | 244657 | 473 | 63243879 |
Paranoia | 14.06 | 9.71 | 85 | 244585 | 11594 | 63232758 |
Waxy flexibility | 14.01 | 9.71 | 8 | 244662 | 134 | 63244218 |
Maximal voluntary ventilation abnormal | 13.95 | 9.71 | 5 | 244665 | 25 | 63244327 |
Anion gap | 13.90 | 9.71 | 21 | 244649 | 1296 | 63243056 |
Internal fixation of fracture | 13.88 | 9.71 | 16 | 244654 | 757 | 63243595 |
Hallucination, olfactory | 13.84 | 9.71 | 10 | 244660 | 255 | 63244097 |
Ear pain | 13.81 | 9.71 | 82 | 244588 | 36036 | 63208316 |
Cerebral microangiopathy | 13.77 | 9.71 | 10 | 244660 | 257 | 63244095 |
Neonatal behavioural syndrome | 13.77 | 9.71 | 6 | 244664 | 54 | 63244298 |
LDL/HDL ratio increased | 13.69 | 9.71 | 3 | 244667 | 0 | 63244352 |
Hyporesponsive to stimuli | 13.69 | 9.71 | 19 | 244651 | 1085 | 63243267 |
Wrong rate | 13.67 | 9.71 | 6 | 244664 | 55 | 63244297 |
Blood pressure systolic abnormal | 13.61 | 9.71 | 19 | 244651 | 13367 | 63230985 |
Congenital central nervous system anomaly | 13.60 | 9.71 | 11 | 244659 | 333 | 63244019 |
Laryngomalacia | 13.49 | 9.71 | 6 | 244664 | 57 | 63244295 |
Hypokalaemia | 13.44 | 9.71 | 508 | 244162 | 103296 | 63141056 |
Erythrodermic psoriasis | 13.35 | 9.71 | 18 | 244652 | 1000 | 63243352 |
Hypotonia neonatal | 13.34 | 9.71 | 20 | 244650 | 1226 | 63243126 |
Phobia | 13.33 | 9.71 | 11 | 244659 | 343 | 63244009 |
Treatment noncompliance | 13.31 | 9.71 | 210 | 244460 | 37115 | 63207237 |
Prothrombin level decreased | 13.24 | 9.71 | 14 | 244656 | 601 | 63243751 |
Oedema | 13.24 | 9.71 | 281 | 244389 | 97341 | 63147011 |
Diabetic ketoacidosis | 13.20 | 9.71 | 38 | 244632 | 20467 | 63223885 |
Vaginal flatulence | 13.20 | 9.71 | 35 | 244635 | 3258 | 63241094 |
Dysgeusia | 13.14 | 9.71 | 253 | 244417 | 46457 | 63197895 |
Cardio-respiratory distress | 13.03 | 9.71 | 8 | 244662 | 154 | 63244198 |
Syncope | 13.01 | 9.71 | 565 | 244105 | 116820 | 63127532 |
Tardive dyskinesia | 12.99 | 9.71 | 66 | 244604 | 8436 | 63235916 |
Eating disorder | 12.97 | 9.71 | 121 | 244549 | 18895 | 63225457 |
Toxic epidermal necrolysis | 12.88 | 9.71 | 52 | 244618 | 25282 | 63219070 |
Cutaneous lymphoma | 12.85 | 9.71 | 8 | 244662 | 158 | 63244194 |
Staphylococcal infection | 12.84 | 9.71 | 227 | 244443 | 41029 | 63203323 |
Cytomegalovirus viraemia | 12.83 | 9.71 | 3 | 244667 | 5646 | 63238706 |
Anterograde amnesia | 12.76 | 9.71 | 13 | 244657 | 534 | 63243818 |
Musculoskeletal disorder | 12.76 | 9.71 | 39 | 244631 | 20605 | 63223747 |
Performance status decreased | 12.68 | 9.71 | 37 | 244633 | 3641 | 63240711 |
Suspiciousness | 12.67 | 9.71 | 11 | 244659 | 368 | 63243984 |
Cognitive disorder | 12.67 | 9.71 | 293 | 244377 | 55522 | 63188830 |
Wrong patient | 12.64 | 9.71 | 9 | 244661 | 224 | 63244128 |
Akathisia | 12.60 | 9.71 | 69 | 244601 | 9077 | 63235275 |
Cellulitis | 12.60 | 9.71 | 231 | 244439 | 81727 | 63162625 |
Multiple organ dysfunction syndrome | 12.53 | 9.71 | 149 | 244521 | 56603 | 63187749 |
Peripheral circulatory failure | 12.52 | 9.71 | 17 | 244653 | 951 | 63243401 |
Divorced | 12.51 | 9.71 | 4 | 244666 | 13 | 63244339 |
Oropharyngeal pain | 12.51 | 9.71 | 273 | 244397 | 94214 | 63150138 |
Burning sensation | 12.47 | 9.71 | 286 | 244384 | 54121 | 63190231 |
Brugada syndrome | 12.45 | 9.71 | 11 | 244659 | 377 | 63243975 |
Brain death | 12.43 | 9.71 | 35 | 244635 | 3375 | 63240977 |
Myoclonus | 12.38 | 9.71 | 104 | 244566 | 15764 | 63228588 |
Libido decreased | 12.38 | 9.71 | 30 | 244640 | 2642 | 63241710 |
Craniosynostosis | 12.38 | 9.71 | 8 | 244662 | 169 | 63244183 |
Rhinorrhoea | 12.34 | 9.71 | 178 | 244492 | 65399 | 63178953 |
Atrioventricular septal defect | 12.27 | 9.71 | 10 | 244660 | 306 | 63244046 |
Nasal polyps | 12.23 | 9.71 | 4 | 244666 | 6035 | 63238317 |
Hyperaldosteronism | 12.20 | 9.71 | 9 | 244661 | 237 | 63244115 |
Pneumonia aspiration | 12.20 | 9.71 | 194 | 244476 | 34346 | 63210006 |
Soliloquy | 12.17 | 9.71 | 9 | 244661 | 238 | 63244114 |
Gallbladder hypofunction | 12.16 | 9.71 | 13 | 244657 | 565 | 63243787 |
Drug screen false positive | 12.16 | 9.71 | 16 | 244654 | 868 | 63243484 |
Cushingoid | 12.09 | 9.71 | 9 | 244661 | 8476 | 63235876 |
Laryngitis | 12.02 | 9.71 | 30 | 244640 | 16937 | 63227415 |
Coagulation factor V level decreased | 11.95 | 9.71 | 10 | 244660 | 318 | 63244034 |
Proctitis | 11.91 | 9.71 | 47 | 244623 | 5394 | 63238958 |
Retrograde amnesia | 11.88 | 9.71 | 12 | 244658 | 488 | 63243864 |
Postnatal growth restriction | 11.87 | 9.71 | 4 | 244666 | 16 | 63244336 |
Crime | 11.87 | 9.71 | 4 | 244666 | 16 | 63244336 |
Balance disorder | 11.86 | 9.71 | 417 | 244253 | 84005 | 63160347 |
Tachycardia | 11.85 | 9.71 | 563 | 244107 | 117593 | 63126759 |
Polyarthritis | 11.79 | 9.71 | 13 | 244657 | 10133 | 63234219 |
Electroencephalogram abnormal | 11.77 | 9.71 | 36 | 244634 | 3636 | 63240716 |
Coma scale abnormal | 11.67 | 9.71 | 45 | 244625 | 5108 | 63239244 |
Burning mouth syndrome | 11.66 | 9.71 | 12 | 244658 | 499 | 63243853 |
Injection site swelling | 11.65 | 9.71 | 122 | 244548 | 47450 | 63196902 |
Carotid pulse abnormal | 11.62 | 9.71 | 3 | 244667 | 3 | 63244349 |
Pelvic floor dysfunction | 11.62 | 9.71 | 3 | 244667 | 3 | 63244349 |
Prothrombin level increased | 11.55 | 9.71 | 9 | 244661 | 258 | 63244094 |
Skin ulcer | 11.54 | 9.71 | 108 | 244562 | 42937 | 63201415 |
Blood creatine phosphokinase increased | 11.54 | 9.71 | 173 | 244497 | 30257 | 63214095 |
Neurosis | 11.52 | 9.71 | 9 | 244661 | 259 | 63244093 |
Premature labour | 11.51 | 9.71 | 19 | 244651 | 12485 | 63231867 |
Deformity | 11.47 | 9.71 | 17 | 244653 | 11667 | 63232685 |
Tendonitis | 11.46 | 9.71 | 38 | 244632 | 19577 | 63224775 |
Ascites | 11.44 | 9.71 | 101 | 244569 | 40627 | 63203725 |
Anxiety disorder | 11.42 | 9.71 | 38 | 244632 | 4012 | 63240340 |
Localised infection | 11.33 | 9.71 | 69 | 244601 | 30141 | 63214211 |
Perseveration | 11.31 | 9.71 | 9 | 244661 | 266 | 63244086 |
Mean cell haemoglobin decreased | 11.27 | 9.71 | 3 | 244667 | 5176 | 63239176 |
Reduced facial expression | 11.25 | 9.71 | 24 | 244646 | 1942 | 63242410 |
Hepatotoxicity | 11.24 | 9.71 | 90 | 244580 | 36951 | 63207401 |
Hepatic cirrhosis | 11.22 | 9.71 | 53 | 244617 | 24681 | 63219671 |
Enthesopathy | 11.20 | 9.71 | 10 | 244660 | 8604 | 63235748 |
Postmortem blood drug level abnormal | 11.19 | 9.71 | 10 | 244660 | 348 | 63244004 |
Throat irritation | 11.18 | 9.71 | 92 | 244578 | 37555 | 63206797 |
Cholecystectomy | 11.18 | 9.71 | 75 | 244595 | 10602 | 63233750 |
Drug ineffective for unapproved indication | 11.17 | 9.71 | 81 | 244589 | 33982 | 63210370 |
Corneal reflex decreased | 11.17 | 9.71 | 7 | 244663 | 140 | 63244212 |
Electrocardiogram repolarisation abnormality | 11.16 | 9.71 | 19 | 244651 | 1298 | 63243054 |
Ligament sprain | 11.13 | 9.71 | 86 | 244584 | 12714 | 63231638 |
Economic problem | 11.08 | 9.71 | 24 | 244646 | 1962 | 63242390 |
Haemangioma congenital | 11.01 | 9.71 | 11 | 244659 | 441 | 63243911 |
Musculoskeletal pain | 10.99 | 9.71 | 271 | 244399 | 92006 | 63152346 |
Asphyxia | 10.90 | 9.71 | 50 | 244620 | 6131 | 63238221 |
Expired product administered | 10.90 | 9.71 | 50 | 244620 | 6131 | 63238221 |
Clostridium difficile infection | 10.88 | 9.71 | 69 | 244601 | 29853 | 63214499 |
Blood alcohol increased | 10.88 | 9.71 | 13 | 244657 | 639 | 63243713 |
Osteonecrosis of jaw | 10.81 | 9.71 | 85 | 244585 | 35038 | 63209314 |
Beta haemolytic streptococcal infection | 10.77 | 9.71 | 24 | 244646 | 2001 | 63242351 |
Product counterfeit | 10.70 | 9.71 | 7 | 244663 | 151 | 63244201 |
Purpura senile | 10.69 | 9.71 | 12 | 244658 | 551 | 63243801 |
Attention deficit hyperactivity disorder | 10.66 | 9.71 | 31 | 244639 | 3045 | 63241307 |
Depersonalisation/derealisation disorder | 10.59 | 9.71 | 19 | 244651 | 1353 | 63242999 |
Mixed anxiety and depressive disorder | 10.57 | 9.71 | 9 | 244661 | 293 | 63244059 |
Polydipsia | 10.55 | 9.71 | 34 | 244636 | 3530 | 63240822 |
Therapeutic response decreased | 10.55 | 9.71 | 170 | 244500 | 61355 | 63182997 |
Neuroglycopenia | 10.50 | 9.71 | 11 | 244659 | 467 | 63243885 |
Sickle cell anaemia with crisis | 10.48 | 9.71 | 5 | 244665 | 5998 | 63238354 |
Mood swings | 10.45 | 9.71 | 112 | 244558 | 18136 | 63226216 |
Feeling of relaxation | 10.44 | 9.71 | 5 | 244665 | 57 | 63244295 |
Analgesic drug level decreased | 10.42 | 9.71 | 3 | 244667 | 6 | 63244346 |
Cardioplegia | 10.42 | 9.71 | 3 | 244667 | 6 | 63244346 |
Hyperinsulinism | 10.42 | 9.71 | 3 | 244667 | 6 | 63244346 |
Skin plaque | 10.41 | 9.71 | 10 | 244660 | 8310 | 63236042 |
Hair texture abnormal | 10.40 | 9.71 | 38 | 244632 | 4205 | 63240147 |
Muscle tightness | 10.38 | 9.71 | 80 | 244590 | 11820 | 63232532 |
Exposure via inhalation | 10.37 | 9.71 | 5 | 244665 | 58 | 63244294 |
Arthritis bacterial | 10.37 | 9.71 | 6 | 244664 | 6457 | 63237895 |
Blood triglycerides increased | 10.37 | 9.71 | 83 | 244587 | 12405 | 63231947 |
Pupil fixed | 10.26 | 9.71 | 22 | 244648 | 1787 | 63242565 |
Blood oestrogen increased | 10.22 | 9.71 | 6 | 244664 | 106 | 63244246 |
Blood lactate dehydrogenase increased | 10.21 | 9.71 | 50 | 244620 | 23066 | 63221286 |
Venoocclusive liver disease | 10.15 | 9.71 | 3 | 244667 | 4832 | 63239520 |
Vasculitis | 10.15 | 9.71 | 36 | 244634 | 18173 | 63226179 |
Tobacco user | 10.13 | 9.71 | 14 | 244656 | 796 | 63243556 |
Lip swelling | 10.12 | 9.71 | 74 | 244596 | 30989 | 63213363 |
Cardiac hypertrophy | 10.10 | 9.71 | 16 | 244654 | 1029 | 63243323 |
Nephropathy toxic | 10.10 | 9.71 | 13 | 244657 | 9466 | 63234886 |
Multiple drug therapy | 10.10 | 9.71 | 34 | 244636 | 3612 | 63240740 |
Oligohydramnios | 10.08 | 9.71 | 6 | 244664 | 6360 | 63237992 |
Violence-related symptom | 10.07 | 9.71 | 10 | 244660 | 398 | 63243954 |
Feeling drunk | 10.07 | 9.71 | 37 | 244633 | 4105 | 63240247 |
Alcohol interaction | 10.06 | 9.71 | 26 | 244644 | 2383 | 63241969 |
Dizziness | 10.05 | 9.71 | 1842 | 242828 | 428083 | 62816269 |
Nail disorder | 10.03 | 9.71 | 22 | 244648 | 12993 | 63231359 |
Vascular pseudoaneurysm ruptured | 10.01 | 9.71 | 5 | 244665 | 63 | 63244289 |
Nephrosclerosis | 10.00 | 9.71 | 16 | 244654 | 1038 | 63243314 |
Pleural effusion | 9.98 | 9.71 | 278 | 244392 | 92932 | 63151420 |
Biliary dyskinesia | 9.94 | 9.71 | 28 | 244642 | 2701 | 63241651 |
Joint dislocation | 9.93 | 9.71 | 38 | 244632 | 18762 | 63225590 |
Sepsis syndrome | 9.91 | 9.71 | 15 | 244655 | 927 | 63243425 |
Anion gap abnormal | 9.91 | 9.71 | 10 | 244660 | 406 | 63243946 |
Alcohol withdrawal syndrome | 9.91 | 9.71 | 14 | 244656 | 813 | 63243539 |
Regurgitation | 9.90 | 9.71 | 21 | 244649 | 1693 | 63242659 |
Labelled drug-food interaction medication error | 9.74 | 9.71 | 7 | 244663 | 177 | 63244175 |
Cross sensitivity reaction | 9.72 | 9.71 | 24 | 244646 | 2138 | 63242214 |
Night sweats | 9.72 | 9.71 | 131 | 244539 | 48683 | 63195669 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug abuse | 7661.01 | 10.68 | 4464 | 109410 | 94632 | 34748425 |
Toxicity to various agents | 2307.32 | 10.68 | 3035 | 110839 | 197327 | 34645730 |
Completed suicide | 2187.99 | 10.68 | 2101 | 111773 | 96067 | 34746990 |
Respiratory arrest | 1833.64 | 10.68 | 1140 | 112734 | 26903 | 34816154 |
Poisoning | 1458.49 | 10.68 | 738 | 113136 | 11488 | 34831569 |
Cardio-respiratory arrest | 1087.32 | 10.68 | 1107 | 112767 | 54166 | 34788891 |
Cardiac arrest | 863.33 | 10.68 | 1297 | 112577 | 94862 | 34748195 |
Intentional product misuse | 781.49 | 10.68 | 849 | 113025 | 44762 | 34798295 |
Drug dependence | 771.69 | 10.68 | 636 | 113238 | 23581 | 34819476 |
Sopor | 719.03 | 10.68 | 464 | 113410 | 11672 | 34831385 |
Coma | 639.64 | 10.68 | 766 | 113108 | 44912 | 34798145 |
Suicide attempt | 617.95 | 10.68 | 698 | 113176 | 38418 | 34804639 |
Overdose | 575.13 | 10.68 | 1049 | 112825 | 90010 | 34753047 |
Intentional overdose | 547.83 | 10.68 | 693 | 113181 | 42981 | 34800076 |
Poisoning deliberate | 418.57 | 10.68 | 281 | 113593 | 7563 | 34835494 |
Exposure via ingestion | 272.64 | 10.68 | 136 | 113738 | 2045 | 34841012 |
Withdrawal syndrome | 261.90 | 10.68 | 259 | 113615 | 12196 | 34830861 |
Drug withdrawal syndrome | 236.32 | 10.68 | 307 | 113567 | 19527 | 34823530 |
Prescription form tampering | 234.76 | 10.68 | 79 | 113795 | 387 | 34842670 |
Off label use | 226.99 | 10.68 | 662 | 113212 | 418862 | 34424195 |
Drug use disorder | 216.08 | 10.68 | 147 | 113727 | 4044 | 34839013 |
Intentional self-injury | 210.90 | 10.68 | 242 | 113632 | 13529 | 34829528 |
Somnolence | 202.07 | 10.68 | 806 | 113068 | 110310 | 34732747 |
Substance abuse | 199.14 | 10.68 | 179 | 113695 | 7462 | 34835595 |
Accidental overdose | 192.12 | 10.68 | 280 | 113594 | 19860 | 34823197 |
Miosis | 183.47 | 10.68 | 189 | 113685 | 9346 | 34833711 |
Suicidal ideation | 157.02 | 10.68 | 382 | 113492 | 40006 | 34803051 |
Drug abuser | 154.09 | 10.68 | 117 | 113757 | 3837 | 34839220 |
Bradypnoea | 150.07 | 10.68 | 101 | 113773 | 2728 | 34840329 |
Anxiety | 148.05 | 10.68 | 679 | 113195 | 98749 | 34744308 |
Respiratory depression | 143.67 | 10.68 | 218 | 113656 | 16027 | 34827030 |
Death | 137.68 | 10.68 | 1934 | 111940 | 396115 | 34446942 |
Agitation | 135.15 | 10.68 | 453 | 113421 | 56946 | 34786111 |
Febrile neutropenia | 133.89 | 10.68 | 149 | 113725 | 136700 | 34706357 |
Drug ineffective | 123.19 | 10.68 | 928 | 112946 | 455823 | 34387234 |
Pyrexia | 118.91 | 10.68 | 620 | 113254 | 332393 | 34510664 |
Depression | 116.70 | 10.68 | 624 | 113250 | 96474 | 34746583 |
Depressed level of consciousness | 112.49 | 10.68 | 351 | 113523 | 42490 | 34800567 |
Drug screen positive | 105.97 | 10.68 | 94 | 113780 | 3849 | 34839208 |
Bradyphrenia | 97.57 | 10.68 | 98 | 113776 | 4700 | 34838357 |
Insomnia | 92.87 | 10.68 | 618 | 113256 | 103289 | 34739768 |
Asphyxia | 89.62 | 10.68 | 111 | 113763 | 6724 | 34836333 |
Accidental death | 87.68 | 10.68 | 69 | 113805 | 2387 | 34840670 |
Pneumonia | 84.67 | 10.68 | 765 | 113109 | 361862 | 34481195 |
Sepsis | 78.32 | 10.68 | 279 | 113595 | 166282 | 34676775 |
Panic attack | 75.62 | 10.68 | 121 | 113753 | 9311 | 34833746 |
Treatment failure | 75.12 | 10.68 | 29 | 113845 | 46668 | 34796389 |
COVID-19 | 73.00 | 10.68 | 87 | 113787 | 77463 | 34765594 |
Aggression | 72.57 | 10.68 | 285 | 113589 | 38679 | 34804378 |
Counterfeit product administered | 70.09 | 10.68 | 25 | 113849 | 150 | 34842907 |
Neutropenia | 69.52 | 10.68 | 269 | 113605 | 156509 | 34686548 |
Unresponsive to stimuli | 66.99 | 10.68 | 220 | 113654 | 27349 | 34815708 |
Renal impairment | 66.81 | 10.68 | 129 | 113745 | 94384 | 34748673 |
Infection | 65.21 | 10.68 | 123 | 113751 | 90792 | 34752265 |
Product use in unapproved indication | 64.16 | 10.68 | 184 | 113690 | 117315 | 34725742 |
Alcohol interaction | 62.00 | 10.68 | 61 | 113813 | 2852 | 34840205 |
C-reactive protein increased | 60.83 | 10.68 | 52 | 113822 | 54046 | 34789011 |
Product counterfeit | 60.60 | 10.68 | 22 | 113852 | 140 | 34842917 |
Amnesia | 60.14 | 10.68 | 207 | 113667 | 26356 | 34816701 |
Cough | 60.09 | 10.68 | 268 | 113606 | 149872 | 34693185 |
Infusion related reaction | 58.44 | 10.68 | 52 | 113822 | 53005 | 34790052 |
Irritability | 57.30 | 10.68 | 194 | 113680 | 24496 | 34818561 |
Lower respiratory tract infection | 57.29 | 10.68 | 16 | 113858 | 31621 | 34811436 |
Cytomegalovirus infection | 55.94 | 10.68 | 9 | 113865 | 26126 | 34816931 |
Drug detoxification | 55.81 | 10.68 | 24 | 113850 | 251 | 34842806 |
Drug resistance | 55.33 | 10.68 | 9 | 113865 | 25918 | 34817139 |
Pulmonary oedema | 54.69 | 10.68 | 302 | 113572 | 47227 | 34795830 |
Platelet count decreased | 54.60 | 10.68 | 203 | 113671 | 119514 | 34723543 |
Abnormal behaviour | 54.30 | 10.68 | 192 | 113682 | 24777 | 34818280 |
Loss of consciousness | 54.15 | 10.68 | 457 | 113417 | 82210 | 34760847 |
Toxicologic test abnormal | 53.24 | 10.68 | 29 | 113845 | 527 | 34842530 |
Anaemia | 53.11 | 10.68 | 495 | 113379 | 232840 | 34610217 |
Self-medication | 50.95 | 10.68 | 53 | 113821 | 2650 | 34840407 |
Postmortem blood drug level abnormal | 50.55 | 10.68 | 23 | 113851 | 278 | 34842779 |
Rash | 50.06 | 10.68 | 474 | 113400 | 222278 | 34620779 |
Condition aggravated | 48.92 | 10.68 | 396 | 113478 | 191800 | 34651257 |
Myelosuppression | 47.76 | 10.68 | 4 | 113870 | 19261 | 34823796 |
Diarrhoea | 47.69 | 10.68 | 940 | 112934 | 388972 | 34454085 |
Disease progression | 46.87 | 10.68 | 187 | 113687 | 107890 | 34735167 |
Drug tolerance | 46.41 | 10.68 | 52 | 113822 | 2830 | 34840227 |
Mucosal inflammation | 44.80 | 10.68 | 36 | 113838 | 38586 | 34804471 |
Tremor | 43.66 | 10.68 | 436 | 113438 | 82151 | 34760906 |
Hepatic function abnormal | 43.65 | 10.68 | 48 | 113826 | 44315 | 34798742 |
Disorientation | 41.66 | 10.68 | 216 | 113658 | 32972 | 34810085 |
Narcotic bowel syndrome | 41.05 | 10.68 | 16 | 113858 | 127 | 34842930 |
Alcohol abuse | 40.13 | 10.68 | 62 | 113812 | 4628 | 34838429 |
General physical health deterioration | 40.07 | 10.68 | 249 | 113625 | 128020 | 34715037 |
Disturbance in attention | 39.88 | 10.68 | 179 | 113695 | 25766 | 34817291 |
Arthralgia | 39.83 | 10.68 | 358 | 113516 | 169683 | 34673374 |
Psychomotor hyperactivity | 39.51 | 10.68 | 93 | 113781 | 9529 | 34833528 |
Substance use disorder | 39.39 | 10.68 | 27 | 113847 | 752 | 34842305 |
Dyspnoea | 39.19 | 10.68 | 932 | 112942 | 375850 | 34467207 |
Cardiac failure | 38.85 | 10.68 | 159 | 113715 | 91089 | 34751968 |
Joint swelling | 38.70 | 10.68 | 86 | 113788 | 59804 | 34783253 |
Acute kidney injury | 38.52 | 10.68 | 731 | 113143 | 304257 | 34538800 |
Altered state of consciousness | 38.29 | 10.68 | 162 | 113712 | 22731 | 34820326 |
Pulmonary congestion | 38.17 | 10.68 | 115 | 113759 | 13650 | 34829407 |
Thinking abnormal | 37.73 | 10.68 | 70 | 113804 | 6067 | 34836990 |
Accidental poisoning | 36.71 | 10.68 | 26 | 113848 | 764 | 34842293 |
Anger | 36.52 | 10.68 | 103 | 113771 | 11781 | 34831276 |
Drug intolerance | 36.51 | 10.68 | 88 | 113786 | 59482 | 34783575 |
Therapeutic product effect incomplete | 35.67 | 10.68 | 69 | 113805 | 50472 | 34792585 |
Abulia | 35.66 | 10.68 | 23 | 113851 | 577 | 34842480 |
Road traffic accident | 35.24 | 10.68 | 131 | 113743 | 17319 | 34825738 |
Brain oedema | 35.11 | 10.68 | 112 | 113762 | 13709 | 34829348 |
Neutrophil count decreased | 35.01 | 10.68 | 71 | 113803 | 51033 | 34792024 |
White blood cell count decreased | 34.85 | 10.68 | 176 | 113698 | 95269 | 34747788 |
Suspected suicide | 34.14 | 10.68 | 58 | 113816 | 4690 | 34838367 |
Drug withdrawal syndrome neonatal | 34.04 | 10.68 | 50 | 113824 | 3569 | 34839488 |
Confusional state | 33.37 | 10.68 | 657 | 113217 | 143503 | 34699554 |
Pancytopenia | 33.32 | 10.68 | 178 | 113696 | 94979 | 34748078 |
Alcohol use | 33.23 | 10.68 | 47 | 113827 | 3241 | 34839816 |
Nervousness | 32.80 | 10.68 | 103 | 113771 | 12503 | 34830554 |
Substance abuser | 32.74 | 10.68 | 13 | 113861 | 109 | 34842948 |
Manic symptom | 32.74 | 10.68 | 13 | 113861 | 109 | 34842948 |
Blood pressure fluctuation | 32.60 | 10.68 | 21 | 113853 | 25228 | 34817829 |
Dependence | 32.07 | 10.68 | 28 | 113846 | 1122 | 34841935 |
Haemoglobin decreased | 32.01 | 10.68 | 246 | 113628 | 120526 | 34722531 |
Rheumatoid arthritis | 31.78 | 10.68 | 47 | 113827 | 38191 | 34804866 |
Prostate cancer | 31.74 | 10.68 | 50 | 113824 | 39599 | 34803458 |
Neutropenic sepsis | 31.19 | 10.68 | 4 | 113870 | 13763 | 34829294 |
Dysarthria | 31.09 | 10.68 | 207 | 113667 | 34575 | 34808482 |
Angioedema | 31.00 | 10.68 | 46 | 113828 | 37328 | 34805729 |
Blood creatinine increased | 30.89 | 10.68 | 182 | 113692 | 94794 | 34748263 |
Mydriasis | 30.86 | 10.68 | 71 | 113803 | 7166 | 34835891 |
Inappropriate schedule of product administration | 30.81 | 10.68 | 102 | 113772 | 62194 | 34780863 |
Withdrawal catatonia | 30.71 | 10.68 | 12 | 113862 | 96 | 34842961 |
Pneumocystis jirovecii pneumonia | 30.46 | 10.68 | 13 | 113861 | 19697 | 34823360 |
Respiratory rate decreased | 30.43 | 10.68 | 38 | 113836 | 2321 | 34840736 |
Anorgasmia | 30.43 | 10.68 | 24 | 113850 | 833 | 34842224 |
Homicide | 30.35 | 10.68 | 25 | 113849 | 924 | 34842133 |
Malignant neoplasm progression | 30.10 | 10.68 | 166 | 113708 | 87880 | 34755177 |
Bradykinesia | 29.92 | 10.68 | 49 | 113825 | 3844 | 34839213 |
Respiratory failure | 29.79 | 10.68 | 219 | 113655 | 108353 | 34734704 |
Ascites | 29.17 | 10.68 | 68 | 113806 | 46503 | 34796554 |
Paramnesia | 28.78 | 10.68 | 8 | 113866 | 17 | 34843040 |
Interstitial lung disease | 28.25 | 10.68 | 113 | 113761 | 65169 | 34777888 |
Cytokine release syndrome | 28.23 | 10.68 | 20 | 113854 | 22857 | 34820200 |
Hyperthermia | 28.05 | 10.68 | 87 | 113787 | 10490 | 34832567 |
Gastrointestinal haemorrhage | 28.01 | 10.68 | 171 | 113703 | 88306 | 34754751 |
Bladder dilatation | 27.66 | 10.68 | 29 | 113845 | 1463 | 34841594 |
Feeling abnormal | 27.45 | 10.68 | 321 | 113553 | 62914 | 34780143 |
Bone marrow failure | 27.32 | 10.68 | 33 | 113841 | 29220 | 34813837 |
Heart rate decreased | 26.40 | 10.68 | 39 | 113835 | 31706 | 34811351 |
Analgesic drug level increased | 26.23 | 10.68 | 22 | 113852 | 834 | 34842223 |
Panic disorder | 26.21 | 10.68 | 26 | 113848 | 1228 | 34841829 |
Exposure during pregnancy | 26.07 | 10.68 | 76 | 113798 | 8858 | 34834199 |
Haematochezia | 26.01 | 10.68 | 72 | 113802 | 46462 | 34796595 |
Pneumonia aspiration | 25.51 | 10.68 | 228 | 113646 | 41675 | 34801382 |
Generalised anxiety disorder | 25.15 | 10.68 | 21 | 113853 | 791 | 34842266 |
Stomatitis | 25.11 | 10.68 | 64 | 113810 | 42450 | 34800607 |
Erythema | 24.87 | 10.68 | 178 | 113696 | 88602 | 34754455 |
Gun shot wound | 24.72 | 10.68 | 24 | 113850 | 1104 | 34841953 |
Alanine aminotransferase increased | 24.64 | 10.68 | 158 | 113716 | 80657 | 34762400 |
Hypervolaemia | 24.62 | 10.68 | 17 | 113857 | 19692 | 34823365 |
Serotonin syndrome | 24.50 | 10.68 | 129 | 113745 | 19804 | 34823253 |
Sedation | 24.50 | 10.68 | 134 | 113740 | 20872 | 34822185 |
Cerebral haemorrhage | 24.39 | 10.68 | 48 | 113826 | 34889 | 34808168 |
Distributive shock | 24.38 | 10.68 | 25 | 113849 | 1229 | 34841828 |
Obstructive airways disorder | 24.29 | 10.68 | 10 | 113864 | 15484 | 34827573 |
Pruritus | 24.00 | 10.68 | 322 | 113552 | 141659 | 34701398 |
Hypervigilance | 23.81 | 10.68 | 11 | 113863 | 138 | 34842919 |
Bronchopulmonary aspergillosis | 23.74 | 10.68 | 9 | 113865 | 14650 | 34828407 |
Hospitalisation | 23.68 | 10.68 | 100 | 113774 | 56802 | 34786255 |
Nasopharyngitis | 23.32 | 10.68 | 133 | 113741 | 69835 | 34773222 |
Renal failure | 23.20 | 10.68 | 293 | 113581 | 130264 | 34712793 |
Hallucination, visual | 23.16 | 10.68 | 117 | 113757 | 17674 | 34825383 |
Dissociative disorder | 23.11 | 10.68 | 16 | 113858 | 453 | 34842604 |
Drug tolerance increased | 22.90 | 10.68 | 16 | 113858 | 460 | 34842597 |
Aspergillus infection | 22.55 | 10.68 | 6 | 113868 | 12248 | 34830809 |
Hyperleukocytosis | 22.31 | 10.68 | 30 | 113844 | 1972 | 34841085 |
Inadequate analgesia | 22.26 | 10.68 | 37 | 113837 | 2938 | 34840119 |
Catatonia | 22.21 | 10.68 | 50 | 113824 | 4975 | 34838082 |
Drug withdrawal convulsions | 22.04 | 10.68 | 23 | 113851 | 1154 | 34841903 |
Anaphylactic reaction | 22.02 | 10.68 | 45 | 113829 | 32256 | 34810801 |
Atrial fibrillation | 22.00 | 10.68 | 274 | 113600 | 122119 | 34720938 |
Deafness neurosensory | 21.88 | 10.68 | 36 | 113838 | 2835 | 34840222 |
Poverty of speech | 21.74 | 10.68 | 12 | 113862 | 224 | 34842833 |
Drug diversion | 21.74 | 10.68 | 20 | 113854 | 859 | 34842198 |
Contraindicated product administered | 21.39 | 10.68 | 23 | 113851 | 21458 | 34821599 |
Ventricular fibrillation | 21.32 | 10.68 | 26 | 113848 | 22928 | 34820129 |
Vestibular ischaemia | 21.20 | 10.68 | 6 | 113868 | 14 | 34843043 |
Psoriatic arthropathy | 21.09 | 10.68 | 20 | 113854 | 19778 | 34823279 |
Chorea | 20.90 | 10.68 | 22 | 113852 | 1115 | 34841942 |
Pathogen resistance | 20.90 | 10.68 | 3 | 113871 | 9479 | 34833578 |
Major depression | 20.77 | 10.68 | 46 | 113828 | 4526 | 34838531 |
Cardiac failure congestive | 20.49 | 10.68 | 173 | 113701 | 83097 | 34759960 |
Bladder cancer | 20.39 | 10.68 | 14 | 113860 | 16264 | 34826793 |
Wheezing | 20.32 | 10.68 | 68 | 113806 | 41334 | 34801723 |
Blood pressure systolic increased | 20.28 | 10.68 | 27 | 113847 | 22925 | 34820132 |
Puncture site haematoma | 20.24 | 10.68 | 10 | 113864 | 147 | 34842910 |
Speech disorder | 20.10 | 10.68 | 148 | 113726 | 25538 | 34817519 |
Dizziness | 20.09 | 10.68 | 550 | 113324 | 217971 | 34625086 |
Oedematous pancreatitis | 20.01 | 10.68 | 15 | 113859 | 482 | 34842575 |
Sudden death | 19.81 | 10.68 | 100 | 113774 | 15101 | 34827956 |
Bacteraemia | 19.76 | 10.68 | 21 | 113853 | 19696 | 34823361 |
Faecal disimpaction | 19.65 | 10.68 | 6 | 113868 | 20 | 34843037 |
Hyporesponsive to stimuli | 19.59 | 10.68 | 21 | 113853 | 1087 | 34841970 |
Myotonia | 19.49 | 10.68 | 7 | 113867 | 43 | 34843014 |
Pleural effusion | 19.36 | 10.68 | 171 | 113703 | 81375 | 34761682 |
Hypersensitivity | 19.29 | 10.68 | 118 | 113756 | 60917 | 34782140 |
Acute myocardial infarction | 19.06 | 10.68 | 100 | 113774 | 53619 | 34789438 |
Asthma | 18.98 | 10.68 | 73 | 113801 | 42583 | 34800474 |
Papillary muscle disorder | 18.92 | 10.68 | 4 | 113870 | 0 | 34843057 |
Legal problem | 18.85 | 10.68 | 10 | 113864 | 172 | 34842885 |
Arthropathy | 18.75 | 10.68 | 37 | 113837 | 26870 | 34816187 |
Hypothermia | 18.70 | 10.68 | 77 | 113797 | 10671 | 34832386 |
Haemorrhage | 18.58 | 10.68 | 95 | 113779 | 51275 | 34791782 |
Delirium | 18.50 | 10.68 | 222 | 113652 | 43769 | 34799288 |
Urticaria | 18.48 | 10.68 | 123 | 113751 | 62254 | 34780803 |
Cerebral congestion | 18.42 | 10.68 | 6 | 113868 | 26 | 34843031 |
Hallucination | 18.33 | 10.68 | 252 | 113622 | 51246 | 34791811 |
Tubulointerstitial nephritis | 18.30 | 10.68 | 25 | 113849 | 20999 | 34822058 |
Hepatotoxicity | 18.25 | 10.68 | 26 | 113848 | 21459 | 34821598 |
Appendicitis | 18.20 | 10.68 | 13 | 113861 | 14794 | 34828263 |
Slow speech | 18.19 | 10.68 | 21 | 113853 | 1181 | 34841876 |
Leukopenia | 18.10 | 10.68 | 125 | 113749 | 62731 | 34780326 |
Oedema peripheral | 18.03 | 10.68 | 278 | 113596 | 119534 | 34723523 |
Memory impairment | 17.96 | 10.68 | 218 | 113656 | 43100 | 34799957 |
Blood triglycerides abnormal | 17.94 | 10.68 | 11 | 113863 | 252 | 34842805 |
Herpes zoster | 17.93 | 10.68 | 55 | 113819 | 34344 | 34808713 |
Feeling jittery | 17.88 | 10.68 | 40 | 113834 | 3963 | 34839094 |
Electrocardiogram QT prolonged | 17.81 | 10.68 | 208 | 113666 | 40744 | 34802313 |
Stevens-Johnson syndrome | 17.43 | 10.68 | 21 | 113853 | 18618 | 34824439 |
Lip swelling | 17.41 | 10.68 | 16 | 113858 | 16064 | 34826993 |
Mania | 17.24 | 10.68 | 69 | 113805 | 9442 | 34833615 |
Inflammation | 17.17 | 10.68 | 42 | 113832 | 28253 | 34814804 |
Nephropathy toxic | 16.90 | 10.68 | 10 | 113864 | 12578 | 34830479 |
Sexual dysfunction | 16.86 | 10.68 | 52 | 113822 | 6251 | 34836806 |
Bacterial prostatitis | 16.82 | 10.68 | 7 | 113867 | 67 | 34842990 |
Growth hormone deficiency | 16.81 | 10.68 | 11 | 113863 | 283 | 34842774 |
Hyperkalaemia | 16.69 | 10.68 | 145 | 113729 | 69244 | 34773813 |
Lymphadenopathy | 16.69 | 10.68 | 43 | 113831 | 28420 | 34814637 |
Anamnestic reaction | 16.68 | 10.68 | 6 | 113868 | 37 | 34843020 |
Leukoencephalopathy | 16.50 | 10.68 | 40 | 113834 | 4175 | 34838882 |
Cerebral infarction | 16.47 | 10.68 | 41 | 113833 | 27414 | 34815643 |
Victim of crime | 16.41 | 10.68 | 12 | 113862 | 371 | 34842686 |
Oesophageal carcinoma | 16.30 | 10.68 | 5 | 113869 | 9299 | 34833758 |
Brachial plexus injury | 16.21 | 10.68 | 7 | 113867 | 74 | 34842983 |
Product substitution | 16.04 | 10.68 | 6 | 113868 | 42 | 34843015 |
Liver function test abnormal | 15.97 | 10.68 | 50 | 113824 | 31024 | 34812033 |
Myocardial infarction | 15.91 | 10.68 | 288 | 113586 | 120797 | 34722260 |
Multiple organ dysfunction syndrome | 15.86 | 10.68 | 166 | 113708 | 76400 | 34766657 |
Peripheral swelling | 15.84 | 10.68 | 166 | 113708 | 76375 | 34766682 |
Hypogammaglobulinaemia | 15.83 | 10.68 | 3 | 113871 | 7737 | 34835320 |
Accident | 15.76 | 10.68 | 44 | 113830 | 5003 | 34838054 |
Hypokinesia | 15.76 | 10.68 | 64 | 113810 | 8816 | 34834241 |
Homicidal ideation | 15.75 | 10.68 | 30 | 113844 | 2652 | 34840405 |
Acute myeloid leukaemia | 15.63 | 10.68 | 22 | 113852 | 18248 | 34824809 |
Incorrect route of product administration | 15.54 | 10.68 | 92 | 113782 | 14753 | 34828304 |
Gastric haemorrhage | 15.49 | 10.68 | 7 | 113867 | 10254 | 34832803 |
Full blood count abnormal | 15.46 | 10.68 | 23 | 113851 | 18645 | 34824412 |
Negativism | 15.45 | 10.68 | 12 | 113862 | 407 | 34842650 |
Therapy partial responder | 15.41 | 10.68 | 6 | 113868 | 9610 | 34833447 |
Cyclothymic disorder | 15.28 | 10.68 | 7 | 113867 | 86 | 34842971 |
Foetal exposure during pregnancy | 15.21 | 10.68 | 68 | 113806 | 38033 | 34805024 |
Liver function test increased | 15.18 | 10.68 | 15 | 113859 | 14550 | 34828507 |
Cardio-respiratory distress | 15.16 | 10.68 | 8 | 113866 | 136 | 34842921 |
Diabetic ketoacidosis | 15.14 | 10.68 | 22 | 113852 | 18010 | 34825047 |
Tachyphylaxis | 15.01 | 10.68 | 8 | 113866 | 139 | 34842918 |
COVID-19 pneumonia | 14.95 | 10.68 | 20 | 113854 | 16947 | 34826110 |
Prothrombin time shortened | 14.90 | 10.68 | 21 | 113853 | 1443 | 34841614 |
Thymus disorder | 14.90 | 10.68 | 4 | 113870 | 7 | 34843050 |
Melaena | 14.83 | 10.68 | 62 | 113812 | 35318 | 34807739 |
Epistaxis | 14.79 | 10.68 | 120 | 113754 | 58131 | 34784926 |
Hypocalcaemia | 14.78 | 10.68 | 36 | 113838 | 24253 | 34818804 |
Thrombocytopenia | 14.67 | 10.68 | 392 | 113482 | 155855 | 34687202 |
Sluggishness | 14.65 | 10.68 | 33 | 113841 | 3284 | 34839773 |
Amimia | 14.55 | 10.68 | 4 | 113870 | 8 | 34843049 |
Lactic acidosis | 14.53 | 10.68 | 61 | 113813 | 34711 | 34808346 |
Chronic fatigue syndrome | 14.50 | 10.68 | 11 | 113863 | 360 | 34842697 |
Therapeutic response decreased | 14.48 | 10.68 | 48 | 113826 | 29265 | 34813792 |
Osteoporosis | 14.45 | 10.68 | 12 | 113862 | 12656 | 34830401 |
Mobility decreased | 14.43 | 10.68 | 50 | 113824 | 30078 | 34812979 |
Ventricular tachyarrhythmia | 14.42 | 10.68 | 11 | 113863 | 363 | 34842694 |
Liver disorder | 14.34 | 10.68 | 57 | 113817 | 32940 | 34810117 |
Low birth weight baby | 14.30 | 10.68 | 4 | 113870 | 7901 | 34835156 |
Oesophagitis chemical | 14.28 | 10.68 | 6 | 113868 | 59 | 34842998 |
Cataract | 14.27 | 10.68 | 41 | 113833 | 26145 | 34816912 |
Second primary malignancy | 14.25 | 10.68 | 4 | 113870 | 7882 | 34835175 |
Sepsis pasteurella | 14.19 | 10.68 | 3 | 113871 | 0 | 34843057 |
Neurotoxicity | 14.14 | 10.68 | 23 | 113851 | 17987 | 34825070 |
Transplant rejection | 14.11 | 10.68 | 8 | 113866 | 10303 | 34832754 |
Squamous cell carcinoma of skin | 14.11 | 10.68 | 9 | 113865 | 10872 | 34832185 |
Body temperature decreased | 14.08 | 10.68 | 13 | 113861 | 13021 | 34830036 |
Physical assault | 14.06 | 10.68 | 18 | 113856 | 1127 | 34841930 |
Hepatic cytolysis | 14.01 | 10.68 | 88 | 113786 | 14408 | 34828649 |
Blood triglycerides decreased | 13.99 | 10.68 | 7 | 113867 | 106 | 34842951 |
Incision site pain | 13.94 | 10.68 | 23 | 113851 | 1815 | 34841242 |
Cellulitis | 13.94 | 10.68 | 108 | 113766 | 52843 | 34790214 |
Upper gastrointestinal haemorrhage | 13.88 | 10.68 | 40 | 113834 | 25478 | 34817579 |
Therapy non-responder | 13.81 | 10.68 | 73 | 113801 | 39073 | 34803984 |
Pneumonitis | 13.81 | 10.68 | 60 | 113814 | 33818 | 34809239 |
Intrusive thoughts | 13.79 | 10.68 | 10 | 113864 | 305 | 34842752 |
Femoral artery aneurysm | 13.79 | 10.68 | 8 | 113866 | 165 | 34842892 |
Prescription drug used without a prescription | 13.78 | 10.68 | 25 | 113849 | 2129 | 34840928 |
Blood creatine phosphokinase | 13.76 | 10.68 | 7 | 113867 | 110 | 34842947 |
Oedema | 13.64 | 10.68 | 90 | 113784 | 45651 | 34797406 |
Product use issue | 13.53 | 10.68 | 136 | 113738 | 63080 | 34779977 |
Bipolar disorder | 13.50 | 10.68 | 34 | 113840 | 3635 | 34839422 |
Drug screen negative | 13.49 | 10.68 | 8 | 113866 | 172 | 34842885 |
Judgement impaired | 13.37 | 10.68 | 13 | 113861 | 599 | 34842458 |
Malaise | 13.36 | 10.68 | 483 | 113391 | 185342 | 34657715 |
Panic reaction | 13.33 | 10.68 | 20 | 113854 | 1455 | 34841602 |
Abdominal distension | 13.29 | 10.68 | 124 | 113750 | 58368 | 34784689 |
Blood lactate dehydrogenase increased | 13.27 | 10.68 | 35 | 113839 | 22955 | 34820102 |
Central nervous system necrosis | 13.27 | 10.68 | 7 | 113867 | 119 | 34842938 |
Tumour lysis syndrome | 13.19 | 10.68 | 22 | 113852 | 17037 | 34826020 |
Oropharyngeal pain | 13.19 | 10.68 | 65 | 113809 | 35420 | 34807637 |
Hepatic enzyme increased | 13.17 | 10.68 | 74 | 113800 | 39006 | 34804051 |
Haemoconcentration | 13.13 | 10.68 | 5 | 113869 | 37 | 34843020 |
Pulmonary fibrosis | 13.08 | 10.68 | 25 | 113849 | 18371 | 34824686 |
Victim of homicide | 13.06 | 10.68 | 7 | 113867 | 123 | 34842934 |
Theft | 13.06 | 10.68 | 9 | 113865 | 253 | 34842804 |
Chemical poisoning | 13.01 | 10.68 | 7 | 113867 | 124 | 34842933 |
Cholangitis | 13.00 | 10.68 | 6 | 113868 | 8683 | 34834374 |
Osteonecrosis of jaw | 12.99 | 10.68 | 24 | 113850 | 17865 | 34825192 |
Alcohol poisoning | 12.91 | 10.68 | 33 | 113841 | 3560 | 34839497 |
Peripheral nerve paresis | 12.90 | 10.68 | 5 | 113869 | 39 | 34843018 |
Exposure via inhalation | 12.90 | 10.68 | 5 | 113869 | 39 | 34843018 |
Basal cell carcinoma | 12.88 | 10.68 | 28 | 113846 | 19630 | 34823427 |
Septic shock | 12.82 | 10.68 | 161 | 113713 | 71673 | 34771384 |
Self esteem decreased | 12.82 | 10.68 | 12 | 113862 | 527 | 34842530 |
Myoclonus | 12.77 | 10.68 | 87 | 113787 | 14638 | 34828419 |
Progressive multifocal leukoencephalopathy | 12.77 | 10.68 | 8 | 113866 | 9756 | 34833301 |
Aplastic anaemia | 12.65 | 10.68 | 8 | 113866 | 9708 | 34833349 |
Anticholinergic syndrome | 12.62 | 10.68 | 18 | 113856 | 1251 | 34841806 |
Impatience | 12.61 | 10.68 | 10 | 113864 | 350 | 34842707 |
Conversion disorder | 12.56 | 10.68 | 10 | 113864 | 352 | 34842705 |
Hyperhidrosis | 12.49 | 10.68 | 329 | 113545 | 75363 | 34767694 |
Personality change | 12.47 | 10.68 | 41 | 113833 | 5098 | 34837959 |
Pulseless electrical activity | 12.41 | 10.68 | 4 | 113870 | 7207 | 34835850 |
Product dose omission issue | 12.40 | 10.68 | 296 | 113578 | 119415 | 34723642 |
Bezoar | 12.38 | 10.68 | 17 | 113857 | 1140 | 34841917 |
Intentional product use issue | 12.26 | 10.68 | 130 | 113744 | 59686 | 34783371 |
Thrombotic microangiopathy | 12.21 | 10.68 | 10 | 113864 | 10620 | 34832437 |
Hallucinations, mixed | 12.16 | 10.68 | 27 | 113847 | 2662 | 34840395 |
Shoplifting | 12.12 | 10.68 | 3 | 113871 | 3 | 34843054 |
Aspartate aminotransferase increased | 12.07 | 10.68 | 152 | 113722 | 67631 | 34775426 |
Acute hepatic failure | 11.99 | 10.68 | 17 | 113857 | 14057 | 34829000 |
Substance-induced mood disorder | 11.98 | 10.68 | 6 | 113868 | 91 | 34842966 |
Euphoric mood | 11.94 | 10.68 | 43 | 113831 | 5598 | 34837459 |
Colitis | 11.91 | 10.68 | 73 | 113801 | 37677 | 34805380 |
Blood alcohol increased | 11.82 | 10.68 | 14 | 113860 | 809 | 34842248 |
Oropharyngeal oedema | 11.81 | 10.68 | 6 | 113868 | 94 | 34842963 |
Nystagmus | 11.78 | 10.68 | 38 | 113836 | 4677 | 34838380 |
Clonus | 11.75 | 10.68 | 27 | 113847 | 2723 | 34840334 |
Mood altered | 11.74 | 10.68 | 59 | 113815 | 8893 | 34834164 |
Extrapyramidal disorder | 11.71 | 10.68 | 77 | 113797 | 12803 | 34830254 |
Polyneuropathy | 11.71 | 10.68 | 19 | 113855 | 14877 | 34828180 |
Adrenergic syndrome | 11.69 | 10.68 | 6 | 113868 | 96 | 34842961 |
Neoplasm progression | 11.62 | 10.68 | 38 | 113836 | 23262 | 34819795 |
Cardiorenal syndrome | 11.56 | 10.68 | 13 | 113861 | 710 | 34842347 |
Apathy | 11.55 | 10.68 | 49 | 113825 | 6883 | 34836174 |
Bronchiectasis | 11.53 | 10.68 | 9 | 113865 | 9792 | 34833265 |
Clostridium difficile colitis | 11.51 | 10.68 | 21 | 113853 | 15709 | 34827348 |
Chloasma | 11.51 | 10.68 | 4 | 113870 | 22 | 34843035 |
Haemolysis | 11.49 | 10.68 | 6 | 113868 | 8088 | 34834969 |
Productive cough | 11.48 | 10.68 | 74 | 113800 | 37739 | 34805318 |
Disease recurrence | 11.46 | 10.68 | 34 | 113840 | 21456 | 34821601 |
Bacterial infection | 11.43 | 10.68 | 24 | 113850 | 17039 | 34826018 |
Erythema multiforme | 11.43 | 10.68 | 7 | 113867 | 8642 | 34834415 |
Influenza | 11.41 | 10.68 | 105 | 113769 | 49561 | 34793496 |
Erectile dysfunction | 11.40 | 10.68 | 110 | 113764 | 20527 | 34822530 |
Urosepsis | 11.36 | 10.68 | 15 | 113859 | 12784 | 34830273 |
Pulmonary toxicity | 11.33 | 10.68 | 3 | 113871 | 6144 | 34836913 |
Injury | 11.30 | 10.68 | 110 | 113764 | 20577 | 34822480 |
Victim of chemical submission | 11.25 | 10.68 | 5 | 113869 | 57 | 34843000 |
Visceral congestion | 11.24 | 10.68 | 12 | 113862 | 618 | 34842439 |
Atrial flutter | 11.21 | 10.68 | 21 | 113853 | 15553 | 34827504 |
Colitis microscopic | 11.17 | 10.68 | 24 | 113850 | 2313 | 34840744 |
Abdominal pain | 11.15 | 10.68 | 428 | 113446 | 163190 | 34679867 |
Obsessive thoughts | 11.11 | 10.68 | 13 | 113861 | 742 | 34842315 |
Pericardial effusion | 11.10 | 10.68 | 42 | 113832 | 24620 | 34818437 |
Loss of personal independence in daily activities | 11.09 | 10.68 | 63 | 113811 | 33116 | 34809941 |
Amnestic disorder | 11.06 | 10.68 | 8 | 113866 | 243 | 34842814 |
Proteinuria | 11.06 | 10.68 | 28 | 113846 | 18614 | 34824443 |
Acute stress disorder | 11.05 | 10.68 | 7 | 113867 | 170 | 34842887 |
Hypercalcaemia | 11.01 | 10.68 | 21 | 113853 | 15447 | 34827610 |
Fear | 11.01 | 10.68 | 65 | 113809 | 10411 | 34832646 |
Drug eruption | 10.96 | 10.68 | 31 | 113843 | 19867 | 34823190 |
Drug ineffective for unapproved indication | 10.93 | 10.68 | 40 | 113834 | 23675 | 34819382 |
Nervous system disorder | 10.92 | 10.68 | 83 | 113791 | 14460 | 34828597 |
Benign mesenteric neoplasm | 10.91 | 10.68 | 3 | 113871 | 6 | 34843051 |
Paranoia | 10.89 | 10.68 | 72 | 113802 | 11996 | 34831061 |
Osteonecrosis | 10.79 | 10.68 | 20 | 113854 | 14870 | 34828187 |
Sputum discoloured | 10.78 | 10.68 | 6 | 113868 | 7806 | 34835251 |
Hypophosphataemia | 10.76 | 10.68 | 12 | 113862 | 11014 | 34832043 |
Urinary tract infection | 10.72 | 10.68 | 201 | 113673 | 83880 | 34759177 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug abuse | 12826.30 | 9.57 | 7743 | 283203 | 154948 | 79298494 |
Completed suicide | 6685.09 | 9.57 | 6175 | 284771 | 239592 | 79213850 |
Toxicity to various agents | 4258.26 | 9.57 | 6368 | 284578 | 415172 | 79038270 |
Respiratory arrest | 3471.11 | 9.57 | 2320 | 288626 | 55230 | 79398212 |
Sopor | 2895.94 | 9.57 | 1689 | 289257 | 31321 | 79422121 |
Poisoning | 2544.41 | 9.57 | 1415 | 289531 | 23857 | 79429585 |
Cardio-respiratory arrest | 2159.63 | 9.57 | 2306 | 288640 | 106204 | 79347238 |
Cardiac arrest | 1888.32 | 9.57 | 2710 | 288236 | 169386 | 79284056 |
Suicide attempt | 1666.36 | 9.57 | 1772 | 289174 | 81160 | 79372282 |
Intentional overdose | 1604.44 | 9.57 | 1955 | 288991 | 104005 | 79349437 |
Coma | 1505.95 | 9.57 | 1846 | 289100 | 98803 | 79354639 |
Poisoning deliberate | 1315.35 | 9.57 | 833 | 290113 | 17995 | 79435447 |
Intentional product misuse | 1273.40 | 9.57 | 1651 | 289295 | 93514 | 79359928 |
Overdose | 1264.90 | 9.57 | 2347 | 288599 | 181859 | 79271583 |
Drug dependence | 1209.33 | 9.57 | 1079 | 289867 | 39690 | 79413752 |
Intentional self-injury | 701.17 | 9.57 | 721 | 290225 | 31698 | 79421744 |
Somnolence | 696.28 | 9.57 | 2184 | 288762 | 236797 | 79216645 |
Death | 523.02 | 9.57 | 3695 | 287251 | 562819 | 78890623 |
Off label use | 457.93 | 9.57 | 1736 | 289210 | 905479 | 78547963 |
Exposure via ingestion | 446.14 | 9.57 | 262 | 290684 | 4912 | 79448530 |
Drug ineffective | 435.44 | 9.57 | 2251 | 288695 | 1078662 | 78374780 |
Drug withdrawal syndrome | 427.95 | 9.57 | 579 | 290367 | 34139 | 79419303 |
Drug use disorder | 404.98 | 9.57 | 299 | 290647 | 8352 | 79445090 |
Substance abuse | 401.24 | 9.57 | 322 | 290624 | 10204 | 79443238 |
Synovitis | 387.78 | 9.57 | 47 | 290899 | 150687 | 79302755 |
Bradyphrenia | 368.86 | 9.57 | 308 | 290638 | 10332 | 79443110 |
Withdrawal syndrome | 357.36 | 9.57 | 465 | 290481 | 26389 | 79427053 |
Pemphigus | 337.12 | 9.57 | 5 | 290941 | 99577 | 79353865 |
Hand deformity | 325.94 | 9.57 | 12 | 290934 | 103907 | 79349535 |
Drug abuser | 309.19 | 9.57 | 220 | 290726 | 5793 | 79447649 |
Lower respiratory tract infection | 305.12 | 9.57 | 52 | 290894 | 129168 | 79324274 |
Suicidal ideation | 300.13 | 9.57 | 778 | 290168 | 75562 | 79377880 |
Drug intolerance | 294.91 | 9.57 | 317 | 290629 | 263802 | 79189640 |
Accidental overdose | 290.86 | 9.57 | 520 | 290426 | 39061 | 79414381 |
Contraindicated product administered | 286.59 | 9.57 | 108 | 290838 | 157430 | 79296012 |
Joint swelling | 283.50 | 9.57 | 383 | 290563 | 288263 | 79165179 |
Anti-cyclic citrullinated peptide antibody positive | 282.19 | 9.57 | 4 | 290942 | 83139 | 79370303 |
Pericarditis | 269.30 | 9.57 | 32 | 290914 | 104204 | 79349238 |
Treatment failure | 269.18 | 9.57 | 143 | 290803 | 170343 | 79283099 |
Anxiety | 266.34 | 9.57 | 1684 | 289262 | 246828 | 79206614 |
Agitation | 259.80 | 9.57 | 878 | 290068 | 98837 | 79354605 |
Systemic lupus erythematosus | 254.58 | 9.57 | 64 | 290882 | 121085 | 79332357 |
Mydriasis | 248.09 | 9.57 | 314 | 290632 | 17329 | 79436113 |
Miosis | 244.54 | 9.57 | 295 | 290651 | 15494 | 79437948 |
Arthropathy | 236.50 | 9.57 | 180 | 290766 | 176931 | 79276511 |
Depression | 233.45 | 9.57 | 1471 | 289475 | 215319 | 79238123 |
Duodenal ulcer perforation | 221.26 | 9.57 | 4 | 290942 | 66207 | 79387235 |
Infusion related reaction | 215.54 | 9.57 | 316 | 290630 | 229921 | 79223521 |
Nasopharyngitis | 204.66 | 9.57 | 384 | 290562 | 253497 | 79199945 |
Maternal exposure during pregnancy | 203.36 | 9.57 | 123 | 290823 | 136415 | 79317027 |
Infection | 200.71 | 9.57 | 359 | 290587 | 241353 | 79212089 |
Depressed level of consciousness | 197.76 | 9.57 | 787 | 290159 | 95865 | 79357577 |
Febrile neutropenia | 196.41 | 9.57 | 338 | 290608 | 230661 | 79222781 |
Glossodynia | 196.18 | 9.57 | 66 | 290880 | 103271 | 79350171 |
Rheumatoid arthritis | 193.29 | 9.57 | 288 | 290658 | 208182 | 79245260 |
Bradypnoea | 193.01 | 9.57 | 167 | 290779 | 5885 | 79447557 |
Helicobacter infection | 191.42 | 9.57 | 17 | 290929 | 69687 | 79383755 |
Respiratory depression | 189.06 | 9.57 | 352 | 290594 | 27278 | 79426164 |
Loss of consciousness | 183.48 | 9.57 | 1144 | 289802 | 166799 | 79286643 |
Arthralgia | 176.71 | 9.57 | 1291 | 289655 | 570512 | 78882930 |
Pyrexia | 168.42 | 9.57 | 1624 | 289322 | 677085 | 78776357 |
Prescription form tampering | 165.63 | 9.57 | 60 | 290886 | 332 | 79453110 |
General physical health deterioration | 163.06 | 9.57 | 490 | 290456 | 274748 | 79178694 |
Swelling | 161.56 | 9.57 | 343 | 290603 | 216368 | 79237074 |
Folliculitis | 159.10 | 9.57 | 11 | 290935 | 55369 | 79398073 |
Panic attack | 156.39 | 9.57 | 301 | 290645 | 23915 | 79429527 |
Therapeutic product effect decreased | 155.18 | 9.57 | 223 | 290723 | 163640 | 79289802 |
Drug screen positive | 151.66 | 9.57 | 146 | 290800 | 5917 | 79447525 |
Altered state of consciousness | 148.55 | 9.57 | 423 | 290523 | 43399 | 79410043 |
Alopecia | 147.97 | 9.57 | 397 | 290549 | 230958 | 79222484 |
Discomfort | 145.46 | 9.57 | 146 | 290800 | 125471 | 79327971 |
Rash | 143.31 | 9.57 | 1384 | 289562 | 576974 | 78876468 |
Victim of chemical submission | 142.08 | 9.57 | 59 | 290887 | 495 | 79452947 |
Wound | 141.56 | 9.57 | 129 | 290817 | 116050 | 79337392 |
Hypersensitivity | 139.26 | 9.57 | 490 | 290456 | 261749 | 79191693 |
Bradykinesia | 139.05 | 9.57 | 159 | 290787 | 7884 | 79445558 |
Tremor | 136.59 | 9.57 | 1075 | 289871 | 169008 | 79284434 |
Hepatic enzyme increased | 135.28 | 9.57 | 290 | 290656 | 182320 | 79271122 |
Pneumonia | 134.40 | 9.57 | 1653 | 289293 | 658593 | 78794849 |
Sleep disorder due to general medical condition, insomnia type | 130.10 | 9.57 | 7 | 290939 | 43549 | 79409893 |
C-reactive protein increased | 127.76 | 9.57 | 170 | 290776 | 128857 | 79324585 |
Rheumatoid factor positive | 123.03 | 9.57 | 33 | 290913 | 59806 | 79393636 |
Disturbance in attention | 121.56 | 9.57 | 435 | 290511 | 50366 | 79403076 |
Alcohol abuse | 120.87 | 9.57 | 122 | 290824 | 5241 | 79448201 |
Insomnia | 119.40 | 9.57 | 1394 | 289552 | 243776 | 79209666 |
Abdominal discomfort | 118.57 | 9.57 | 491 | 290455 | 250236 | 79203206 |
Peripheral swelling | 118.38 | 9.57 | 543 | 290403 | 269074 | 79184368 |
Cough | 118.04 | 9.57 | 818 | 290128 | 365971 | 79087471 |
Product use in unapproved indication | 115.47 | 9.57 | 495 | 290451 | 249864 | 79203578 |
Myelosuppression | 112.91 | 9.57 | 9 | 290937 | 40287 | 79413155 |
Muscle injury | 111.43 | 9.57 | 21 | 290925 | 48540 | 79404902 |
Stomatitis | 107.07 | 9.57 | 235 | 290711 | 146522 | 79306920 |
Accidental death | 106.71 | 9.57 | 103 | 290843 | 4188 | 79449254 |
COVID-19 | 106.59 | 9.57 | 263 | 290683 | 157411 | 79296031 |
Sepsis | 105.97 | 9.57 | 564 | 290382 | 268864 | 79184578 |
Drug resistance | 104.11 | 9.57 | 15 | 290931 | 42198 | 79411244 |
Blister | 100.40 | 9.57 | 176 | 290770 | 119300 | 79334142 |
Aggression | 100.25 | 9.57 | 410 | 290536 | 50548 | 79402894 |
Condition aggravated | 98.69 | 9.57 | 1263 | 289683 | 499861 | 78953581 |
Renal impairment | 96.93 | 9.57 | 276 | 290670 | 157507 | 79295935 |
Suspected suicide | 95.00 | 9.57 | 152 | 290794 | 10424 | 79443018 |
Neutropenia | 94.32 | 9.57 | 638 | 290308 | 287072 | 79166370 |
Product use issue | 93.00 | 9.57 | 421 | 290525 | 209401 | 79244041 |
Disorientation | 92.01 | 9.57 | 463 | 290483 | 62313 | 79391129 |
Cytomegalovirus infection | 90.58 | 9.57 | 22 | 290924 | 42622 | 79410820 |
Hepatocellular injury | 89.76 | 9.57 | 378 | 290568 | 47215 | 79406227 |
Sinusitis | 89.22 | 9.57 | 388 | 290558 | 195113 | 79258329 |
Wheezing | 88.27 | 9.57 | 183 | 290763 | 116481 | 79336961 |
Impaired healing | 87.26 | 9.57 | 115 | 290831 | 87540 | 79365902 |
Rheumatic fever | 87.06 | 9.57 | 4 | 290942 | 28521 | 79424921 |
Gastrointestinal disorder | 85.63 | 9.57 | 200 | 290746 | 122005 | 79331437 |
Abnormal behaviour | 85.54 | 9.57 | 310 | 290636 | 36111 | 79417331 |
Dyspnoea | 85.26 | 9.57 | 2429 | 288517 | 854596 | 78598846 |
Mucosal inflammation | 85.04 | 9.57 | 90 | 290856 | 75490 | 79377952 |
Psoriatic arthropathy | 83.24 | 9.57 | 97 | 290849 | 77902 | 79375540 |
Confusional state | 82.05 | 9.57 | 1622 | 289324 | 316375 | 79137067 |
Hypokinesia | 80.85 | 9.57 | 200 | 290746 | 18860 | 79434582 |
Irritable bowel syndrome | 80.82 | 9.57 | 65 | 290881 | 62176 | 79391266 |
Musculoskeletal stiffness | 80.67 | 9.57 | 346 | 290600 | 174662 | 79278780 |
Substance use disorder | 79.56 | 9.57 | 47 | 290899 | 891 | 79452551 |
Neutropenic sepsis | 78.84 | 9.57 | 5 | 290941 | 27059 | 79426383 |
Intentional product use issue | 78.18 | 9.57 | 288 | 290658 | 151824 | 79301618 |
Psychomotor hyperactivity | 74.88 | 9.57 | 180 | 290766 | 16669 | 79436773 |
Drug detoxification | 74.26 | 9.57 | 34 | 290912 | 369 | 79453073 |
Platelet count decreased | 73.48 | 9.57 | 413 | 290533 | 194251 | 79259191 |
Blood pressure fluctuation | 72.19 | 9.57 | 83 | 290863 | 67062 | 79386380 |
Dependence | 71.56 | 9.57 | 64 | 290882 | 2358 | 79451084 |
Neutrophil count decreased | 71.40 | 9.57 | 147 | 290799 | 93812 | 79359630 |
Toxicologic test abnormal | 70.48 | 9.57 | 50 | 290896 | 1310 | 79452132 |
Irritability | 69.38 | 9.57 | 316 | 290630 | 40828 | 79412614 |
Asphyxia | 68.82 | 9.57 | 140 | 290806 | 11580 | 79441862 |
Mobility decreased | 68.39 | 9.57 | 223 | 290723 | 121952 | 79331490 |
Malignant neoplasm progression | 67.59 | 9.57 | 261 | 290685 | 135729 | 79317713 |
Homicide | 67.06 | 9.57 | 46 | 290900 | 1140 | 79452302 |
Nervousness | 66.63 | 9.57 | 270 | 290676 | 33145 | 79420297 |
Unresponsive to stimuli | 66.56 | 9.57 | 389 | 290557 | 55399 | 79398043 |
Electrocardiogram QT prolonged | 66.40 | 9.57 | 560 | 290386 | 89826 | 79363616 |
Serotonin syndrome | 64.51 | 9.57 | 330 | 290616 | 44697 | 79408745 |
Alcohol interaction | 64.21 | 9.57 | 84 | 290862 | 4790 | 79448652 |
Drug interaction | 64.11 | 9.57 | 1975 | 288971 | 413208 | 79040234 |
Therapeutic product effect incomplete | 64.07 | 9.57 | 282 | 290664 | 141363 | 79312079 |
Knee arthroplasty | 62.92 | 9.57 | 40 | 290906 | 43208 | 79410234 |
Diarrhoea | 62.72 | 9.57 | 2602 | 288344 | 877887 | 78575555 |
Fall | 62.65 | 9.57 | 2270 | 288676 | 485359 | 78968083 |
Euphoric mood | 62.60 | 9.57 | 106 | 290840 | 7620 | 79445822 |
Amnesia | 61.72 | 9.57 | 418 | 290528 | 62639 | 79390803 |
Disease progression | 60.29 | 9.57 | 409 | 290537 | 183953 | 79269489 |
Crying | 60.05 | 9.57 | 203 | 290743 | 22840 | 79430602 |
Psychomotor skills impaired | 59.50 | 9.57 | 84 | 290862 | 5153 | 79448289 |
Product counterfeit | 59.18 | 9.57 | 26 | 290920 | 254 | 79453188 |
Counterfeit product administered | 58.30 | 9.57 | 21 | 290925 | 114 | 79453328 |
Ill-defined disorder | 58.14 | 9.57 | 94 | 290852 | 65781 | 79387661 |
Therapy non-responder | 57.75 | 9.57 | 160 | 290786 | 92145 | 79361297 |
Blood pressure systolic increased | 56.88 | 9.57 | 98 | 290848 | 66888 | 79386554 |
Thinking abnormal | 56.78 | 9.57 | 139 | 290807 | 13022 | 79440420 |
Anaemia | 56.37 | 9.57 | 1216 | 289730 | 443799 | 79009643 |
Speech disorder | 56.36 | 9.57 | 366 | 290580 | 54079 | 79399363 |
Postmortem blood drug level abnormal | 56.07 | 9.57 | 33 | 290913 | 621 | 79452821 |
Pancytopenia | 56.05 | 9.57 | 364 | 290582 | 165381 | 79288061 |
Hallucination, visual | 55.65 | 9.57 | 252 | 290694 | 32477 | 79420965 |
Anhedonia | 55.62 | 9.57 | 149 | 290797 | 14749 | 79438693 |
Vertigo | 54.50 | 9.57 | 435 | 290511 | 68647 | 79384795 |
Hepatic function abnormal | 54.18 | 9.57 | 116 | 290830 | 72991 | 79380451 |
Anticholinergic syndrome | 53.53 | 9.57 | 66 | 290880 | 3545 | 79449897 |
Dysarthria | 53.45 | 9.57 | 426 | 290520 | 67196 | 79386246 |
Cardiac failure | 52.38 | 9.57 | 340 | 290606 | 154502 | 79298940 |
Respiratory acidosis | 52.32 | 9.57 | 122 | 290824 | 11078 | 79442364 |
Delirium | 52.28 | 9.57 | 505 | 290441 | 84122 | 79369320 |
Sedation | 51.99 | 9.57 | 346 | 290600 | 51549 | 79401893 |
Obstructive airways disorder | 51.69 | 9.57 | 25 | 290921 | 31434 | 79422008 |
Memory impairment | 51.54 | 9.57 | 629 | 290317 | 111105 | 79342337 |
Feeling abnormal | 50.49 | 9.57 | 839 | 290107 | 158360 | 79295082 |
Liver injury | 49.76 | 9.57 | 81 | 290865 | 56533 | 79396909 |
Inflammation | 48.49 | 9.57 | 177 | 290769 | 93576 | 79359866 |
Blood pressure diastolic decreased | 48.16 | 9.57 | 25 | 290921 | 30191 | 79423251 |
Hip arthroplasty | 48.12 | 9.57 | 36 | 290910 | 35720 | 79417722 |
Urinary retention | 47.66 | 9.57 | 362 | 290584 | 56268 | 79397174 |
Asthma | 47.57 | 9.57 | 293 | 290653 | 134802 | 79318640 |
Herpes zoster | 46.67 | 9.57 | 178 | 290768 | 92905 | 79360537 |
Major depression | 46.61 | 9.57 | 102 | 290844 | 8878 | 79444564 |
Sluggishness | 46.55 | 9.57 | 85 | 290861 | 6487 | 79446955 |
Self-medication | 46.42 | 9.57 | 74 | 290872 | 5058 | 79448384 |
Pulmonary congestion | 46.33 | 9.57 | 209 | 290737 | 26891 | 79426551 |
Urticaria | 45.77 | 9.57 | 443 | 290503 | 184758 | 79268684 |
Alcohol use | 45.56 | 9.57 | 71 | 290875 | 4760 | 79448682 |
Emotional distress | 45.30 | 9.57 | 275 | 290671 | 39694 | 79413748 |
Bone erosion | 44.81 | 9.57 | 6 | 290940 | 17841 | 79435601 |
Blood creatinine increased | 44.45 | 9.57 | 357 | 290589 | 154700 | 79298742 |
Inappropriate schedule of product administration | 44.40 | 9.57 | 295 | 290651 | 133333 | 79320109 |
Prostate cancer | 44.12 | 9.57 | 34 | 290912 | 33234 | 79420208 |
Drug hypersensitivity | 44.10 | 9.57 | 796 | 290150 | 298120 | 79155322 |
Anger | 43.67 | 9.57 | 150 | 290796 | 17012 | 79436430 |
Ascites | 43.62 | 9.57 | 136 | 290810 | 75426 | 79378016 |
Pneumocystis jirovecii pneumonia | 43.40 | 9.57 | 33 | 290913 | 32475 | 79420967 |
Live birth | 43.23 | 9.57 | 8 | 290938 | 18736 | 79434706 |
Grip strength decreased | 43.21 | 9.57 | 13 | 290933 | 21856 | 79431586 |
Bronchiectasis | 42.99 | 9.57 | 14 | 290932 | 22372 | 79431070 |
Anaphylactic reaction | 42.07 | 9.57 | 160 | 290786 | 83583 | 79369859 |
Haemoglobin decreased | 41.71 | 9.57 | 565 | 290381 | 221554 | 79231888 |
Mania | 41.68 | 9.57 | 154 | 290792 | 18106 | 79435336 |
Inadequate analgesia | 40.85 | 9.57 | 66 | 290880 | 4563 | 79448879 |
Poverty of speech | 40.77 | 9.57 | 26 | 290920 | 568 | 79452874 |
Liver disorder | 39.95 | 9.57 | 133 | 290813 | 72284 | 79381158 |
Pruritus | 39.95 | 9.57 | 1115 | 289831 | 393533 | 79059909 |
Transplant rejection | 39.42 | 9.57 | 11 | 290935 | 19426 | 79434016 |
Alcohol poisoning | 38.87 | 9.57 | 66 | 290880 | 4755 | 79448687 |
Panic disorder | 38.54 | 9.57 | 51 | 290895 | 2941 | 79450501 |
Acute kidney injury | 38.32 | 9.57 | 1528 | 289418 | 517876 | 78935566 |
Substance abuser | 38.05 | 9.57 | 16 | 290930 | 139 | 79453303 |
Hallucinations, mixed | 37.68 | 9.57 | 80 | 290866 | 6819 | 79446623 |
Body temperature decreased | 37.61 | 9.57 | 37 | 290909 | 32108 | 79421334 |
Hallucination | 37.10 | 9.57 | 477 | 290469 | 85268 | 79368174 |
Hypothermia | 37.09 | 9.57 | 173 | 290773 | 22573 | 79430869 |
Drug withdrawal convulsions | 36.89 | 9.57 | 43 | 290903 | 2177 | 79451265 |
Neurotoxicity | 36.26 | 9.57 | 39 | 290907 | 32479 | 79420963 |
Multiple organ dysfunction syndrome | 36.26 | 9.57 | 273 | 290673 | 119973 | 79333469 |
White blood cell count decreased | 35.68 | 9.57 | 478 | 290468 | 187810 | 79265632 |
Stupor | 35.60 | 9.57 | 78 | 290868 | 6794 | 79446648 |
Cytomegalovirus viraemia | 35.54 | 9.57 | 3 | 290943 | 12818 | 79440624 |
Gastrointestinal haemorrhage | 35.38 | 9.57 | 356 | 290590 | 147363 | 79306079 |
Fatigue | 35.18 | 9.57 | 2918 | 288028 | 926809 | 78526633 |
Metastases to liver | 35.00 | 9.57 | 31 | 290915 | 28283 | 79425159 |
Hallucination, auditory | 34.93 | 9.57 | 159 | 290787 | 20534 | 79432908 |
Aplastic anaemia | 34.74 | 9.57 | 11 | 290935 | 17894 | 79435548 |
Pneumonia aspiration | 33.98 | 9.57 | 384 | 290562 | 66583 | 79386859 |
Blood pressure diastolic abnormal | 33.52 | 9.57 | 14 | 290932 | 19188 | 79434254 |
Mental disorder | 33.36 | 9.57 | 212 | 290734 | 31090 | 79422352 |
Red blood cell sedimentation rate increased | 33.13 | 9.57 | 74 | 290872 | 45868 | 79407574 |
Prescription drug used without a prescription | 33.04 | 9.57 | 56 | 290890 | 4029 | 79449413 |
Extrapyramidal disorder | 33.03 | 9.57 | 167 | 290779 | 22512 | 79430930 |
Fear | 32.80 | 9.57 | 163 | 290783 | 21823 | 79431619 |
Full blood count abnormal | 32.75 | 9.57 | 61 | 290885 | 40413 | 79413029 |
Accidental poisoning | 32.51 | 9.57 | 35 | 290911 | 1622 | 79451820 |
Tubulointerstitial nephritis | 32.40 | 9.57 | 56 | 290890 | 38179 | 79415263 |
Venoocclusive liver disease | 31.97 | 9.57 | 3 | 290943 | 11768 | 79441674 |
Productive cough | 31.91 | 9.57 | 190 | 290756 | 88141 | 79365301 |
Persistent genital arousal disorder | 31.77 | 9.57 | 17 | 290929 | 264 | 79453178 |
Exposure during pregnancy | 31.74 | 9.57 | 227 | 290719 | 100905 | 79352537 |
Chemical submission | 31.54 | 9.57 | 18 | 290928 | 319 | 79453123 |
Septic shock | 31.50 | 9.57 | 291 | 290655 | 122510 | 79330932 |
Respiratory rate decreased | 31.22 | 9.57 | 63 | 290883 | 5180 | 79448262 |
Osmolar gap increased | 31.21 | 9.57 | 13 | 290933 | 110 | 79453332 |
Tenosynovitis | 31.18 | 9.57 | 9 | 290937 | 15545 | 79437897 |
Suicidal behaviour | 31.01 | 9.57 | 48 | 290898 | 3199 | 79450243 |
Gun shot wound | 30.83 | 9.57 | 29 | 290917 | 1141 | 79452301 |
Hyperhidrosis | 30.79 | 9.57 | 747 | 290199 | 150745 | 79302697 |
Diabetic ketoacidosis | 30.76 | 9.57 | 48 | 290898 | 34074 | 79419368 |
Pain in extremity | 30.75 | 9.57 | 1055 | 289891 | 363483 | 79089959 |
Hyporesponsive to stimuli | 30.69 | 9.57 | 38 | 290908 | 2050 | 79451392 |
Abulia | 30.23 | 9.57 | 27 | 290919 | 993 | 79452449 |
Manic symptom | 30.14 | 9.57 | 13 | 290933 | 121 | 79453321 |
Cellulitis | 29.93 | 9.57 | 254 | 290692 | 108806 | 79344636 |
Inappropriate antidiuretic hormone secretion | 29.79 | 9.57 | 181 | 290765 | 26132 | 79427310 |
Psychomotor retardation | 29.59 | 9.57 | 68 | 290878 | 6116 | 79447326 |
Angioedema | 29.38 | 9.57 | 160 | 290786 | 75875 | 79377567 |
Blood test abnormal | 29.21 | 9.57 | 14 | 290932 | 17696 | 79435746 |
Arthritis | 29.13 | 9.57 | 273 | 290673 | 114607 | 79338835 |
Sleep disorder due to a general medical condition | 29.11 | 9.57 | 8 | 290938 | 14269 | 79439173 |
Leukopenia | 29.07 | 9.57 | 278 | 290668 | 116235 | 79337207 |
Narcotic bowel syndrome | 29.04 | 9.57 | 16 | 290930 | 264 | 79453178 |
Haemorrhage | 28.85 | 9.57 | 204 | 290742 | 90914 | 79362528 |
Fibromyalgia | 28.53 | 9.57 | 129 | 290817 | 64211 | 79389231 |
Cytokine release syndrome | 28.47 | 9.57 | 55 | 290891 | 35943 | 79417499 |
Drug-induced liver injury | 28.47 | 9.57 | 134 | 290812 | 65983 | 79387459 |
Apathy | 28.41 | 9.57 | 108 | 290838 | 12869 | 79440573 |
Multiple injuries | 28.38 | 9.57 | 48 | 290898 | 3447 | 79449995 |
Dysphoria | 28.33 | 9.57 | 57 | 290889 | 4677 | 79448765 |
Immobilisation prolonged | 28.27 | 9.57 | 12 | 290934 | 107 | 79453335 |
Liver function test increased | 27.92 | 9.57 | 65 | 290881 | 39708 | 79413734 |
Foot deformity | 27.83 | 9.57 | 28 | 290918 | 24046 | 79429396 |
Cerebral haemorrhage | 27.81 | 9.57 | 112 | 290834 | 57561 | 79395881 |
Impaired driving ability | 27.53 | 9.57 | 61 | 290885 | 5354 | 79448088 |
Pleural effusion | 27.43 | 9.57 | 369 | 290577 | 144893 | 79308549 |
Osteoarthritis | 27.38 | 9.57 | 196 | 290750 | 87113 | 79366329 |
Adjustment disorder with mixed anxiety and depressed mood | 27.33 | 9.57 | 12 | 290934 | 117 | 79453325 |
Medication error | 27.26 | 9.57 | 376 | 290570 | 68266 | 79385176 |
Oesophageal carcinoma | 27.19 | 9.57 | 4 | 290942 | 11080 | 79442362 |
Heart rate decreased | 27.15 | 9.57 | 148 | 290798 | 70168 | 79383274 |
Cyanosis | 27.12 | 9.57 | 171 | 290775 | 25011 | 79428431 |
Haematochezia | 26.89 | 9.57 | 198 | 290748 | 87447 | 79365995 |
Haemophagocytic lymphohistiocytosis | 26.88 | 9.57 | 24 | 290922 | 21813 | 79431629 |
Therapy partial responder | 26.84 | 9.57 | 15 | 290931 | 17382 | 79436060 |
Appendicitis | 26.64 | 9.57 | 22 | 290924 | 20772 | 79432670 |
Head injury | 26.63 | 9.57 | 230 | 290716 | 37139 | 79416303 |
Cholecystitis chronic | 26.46 | 9.57 | 88 | 290858 | 9818 | 79443624 |
Macular degeneration | 26.40 | 9.57 | 96 | 290850 | 11200 | 79442242 |
Tumour lysis syndrome | 26.37 | 9.57 | 29 | 290917 | 23910 | 79429532 |
Drug ineffective for unapproved indication | 26.32 | 9.57 | 97 | 290849 | 51141 | 79402301 |
Road traffic accident | 26.20 | 9.57 | 259 | 290687 | 43405 | 79410037 |
Aspergillus infection | 26.16 | 9.57 | 19 | 290927 | 19142 | 79434300 |
Cardio-respiratory distress | 26.08 | 9.57 | 15 | 290931 | 270 | 79453172 |
Distributive shock | 26.05 | 9.57 | 40 | 290906 | 2647 | 79450795 |
Obsessive-compulsive disorder | 25.99 | 9.57 | 63 | 290883 | 5864 | 79447578 |
Feeling jittery | 25.79 | 9.57 | 104 | 290842 | 12737 | 79440705 |
Nephropathy toxic | 25.67 | 9.57 | 22 | 290924 | 20397 | 79433045 |
Slow speech | 25.60 | 9.57 | 38 | 290908 | 2440 | 79451002 |
Oropharyngeal pain | 25.58 | 9.57 | 265 | 290681 | 109088 | 79344354 |
Hyperleukocytosis | 25.51 | 9.57 | 39 | 290907 | 2571 | 79450871 |
Depressed mood | 25.51 | 9.57 | 280 | 290666 | 48200 | 79405242 |
Anorgasmia | 25.51 | 9.57 | 27 | 290919 | 1227 | 79452215 |
Wound infection | 25.41 | 9.57 | 30 | 290916 | 23961 | 79429481 |
Breast cancer stage III | 25.41 | 9.57 | 3 | 290943 | 9823 | 79443619 |
Catatonia | 25.39 | 9.57 | 80 | 290866 | 8676 | 79444766 |
Bacteraemia | 25.23 | 9.57 | 51 | 290895 | 32773 | 79420669 |
Premature delivery | 25.23 | 9.57 | 29 | 290917 | 23438 | 79430004 |
Paramnesia | 25.01 | 9.57 | 8 | 290938 | 28 | 79453414 |
Analgesic drug level increased | 24.95 | 9.57 | 43 | 290903 | 3135 | 79450307 |
Withdrawal catatonia | 24.87 | 9.57 | 13 | 290933 | 192 | 79453250 |
Poor venous access | 24.77 | 9.57 | 18 | 290928 | 18131 | 79435311 |
Blood pressure diastolic increased | 24.75 | 9.57 | 11 | 290935 | 14531 | 79438911 |
Suspected counterfeit product | 24.65 | 9.57 | 19 | 290927 | 567 | 79452875 |
Enthesopathy | 24.63 | 9.57 | 6 | 290940 | 11602 | 79441840 |
Generalised anxiety disorder | 24.61 | 9.57 | 35 | 290911 | 2162 | 79451280 |
Bronchopulmonary aspergillosis | 24.57 | 9.57 | 27 | 290919 | 22267 | 79431175 |
Rhabdomyolysis | 24.54 | 9.57 | 520 | 290426 | 102611 | 79350831 |
Toxic epidermal necrolysis | 24.50 | 9.57 | 82 | 290864 | 44499 | 79408943 |
Joint range of motion decreased | 24.50 | 9.57 | 53 | 290893 | 33229 | 79420213 |
Joint effusion | 24.42 | 9.57 | 18 | 290928 | 17996 | 79435446 |
Diffuse large B-cell lymphoma | 24.41 | 9.57 | 7 | 290939 | 12142 | 79441300 |
Procedural pain | 24.39 | 9.57 | 156 | 290790 | 22928 | 79430514 |
Pathogen resistance | 24.17 | 9.57 | 11 | 290935 | 14331 | 79439111 |
Bone marrow failure | 24.17 | 9.57 | 100 | 290846 | 51007 | 79402435 |
Obsessive thoughts | 24.15 | 9.57 | 25 | 290921 | 1107 | 79452335 |
Osteonecrosis of jaw | 24.11 | 9.57 | 79 | 290867 | 43147 | 79410295 |
Parkinsonism | 24.07 | 9.57 | 122 | 290824 | 16462 | 79436980 |
Adrenal insufficiency | 23.89 | 9.57 | 42 | 290904 | 28445 | 79424997 |
Nightmare | 23.87 | 9.57 | 169 | 290777 | 25692 | 79427750 |
Hypervolaemia | 23.82 | 9.57 | 78 | 290868 | 42612 | 79410830 |
Blood lactate dehydrogenase increased | 23.68 | 9.57 | 69 | 290877 | 39101 | 79414341 |
Homicidal ideation | 23.59 | 9.57 | 44 | 290902 | 3413 | 79450029 |
Housebound | 23.52 | 9.57 | 17 | 290929 | 459 | 79452983 |
Delusion | 23.45 | 9.57 | 141 | 290805 | 20282 | 79433160 |
Alanine aminotransferase increased | 23.30 | 9.57 | 435 | 290511 | 162135 | 79291307 |
Benzodiazepine drug level abnormal | 23.09 | 9.57 | 5 | 290941 | 0 | 79453442 |
Stevens-Johnson syndrome | 22.95 | 9.57 | 70 | 290876 | 39096 | 79414346 |
Restlessness | 22.87 | 9.57 | 265 | 290681 | 46227 | 79407215 |
Adverse drug reaction | 22.84 | 9.57 | 145 | 290801 | 66247 | 79387195 |
Hallucination, gustatory | 22.83 | 9.57 | 9 | 290937 | 65 | 79453377 |
Ankylosing spondylitis | 22.80 | 9.57 | 8 | 290938 | 12197 | 79441245 |
Lip swelling | 22.66 | 9.57 | 75 | 290871 | 40836 | 79412606 |
Pulmonary oedema | 22.64 | 9.57 | 450 | 290496 | 87804 | 79365638 |
Blood bilirubin increased | 22.61 | 9.57 | 145 | 290801 | 66087 | 79387355 |
Joint stiffness | 22.51 | 9.57 | 75 | 290871 | 40755 | 79412687 |
Substance use | 22.44 | 9.57 | 22 | 290924 | 912 | 79452530 |
Wrong patient received product | 22.34 | 9.57 | 51 | 290895 | 4567 | 79448875 |
Myoclonus | 22.26 | 9.57 | 175 | 290771 | 27485 | 79425957 |
Upper gastrointestinal haemorrhage | 22.14 | 9.57 | 77 | 290869 | 41303 | 79412139 |
Oedema | 22.13 | 9.57 | 305 | 290641 | 119275 | 79334167 |
Multiple-drug resistance | 22.02 | 9.57 | 3 | 290943 | 8805 | 79444637 |
Electrocardiogram QRS complex prolonged | 21.97 | 9.57 | 88 | 290858 | 10745 | 79442697 |
Feeling of despair | 21.93 | 9.57 | 38 | 290908 | 2783 | 79450659 |
Facet joint syndrome | 21.82 | 9.57 | 7 | 290939 | 11295 | 79442147 |
Clostridium difficile infection | 21.80 | 9.57 | 81 | 290865 | 42604 | 79410838 |
Haematotoxicity | 21.70 | 9.57 | 15 | 290931 | 15504 | 79437938 |
Mood altered | 21.64 | 9.57 | 125 | 290821 | 17722 | 79435720 |
Pulmonary toxicity | 21.62 | 9.57 | 10 | 290936 | 12904 | 79440538 |
Epstein-Barr virus infection | 21.43 | 9.57 | 13 | 290933 | 14403 | 79439039 |
Peripheral venous disease | 21.43 | 9.57 | 16 | 290930 | 15893 | 79437549 |
Lip dry | 21.43 | 9.57 | 15 | 290931 | 15403 | 79438039 |
Uveitis | 21.32 | 9.57 | 18 | 290928 | 16812 | 79436630 |
Interstitial lung disease | 21.27 | 9.57 | 286 | 290660 | 112314 | 79341128 |
Pregnancy | 21.26 | 9.57 | 41 | 290905 | 26810 | 79426632 |
Blood pressure systolic abnormal | 21.18 | 9.57 | 19 | 290927 | 17228 | 79436214 |
Drug tolerance increased | 21.17 | 9.57 | 18 | 290928 | 619 | 79452823 |
Hyponatraemic encephalopathy | 21.17 | 9.57 | 14 | 290932 | 326 | 79453116 |
Exposure via inhalation | 21.11 | 9.57 | 10 | 290936 | 118 | 79453324 |
Liver function test abnormal | 21.07 | 9.57 | 143 | 290803 | 64332 | 79389110 |
Dissociative disorder | 20.97 | 9.57 | 20 | 290926 | 801 | 79452641 |
Self-injurious ideation | 20.82 | 9.57 | 43 | 290903 | 3595 | 79449847 |
Tension | 20.60 | 9.57 | 48 | 290898 | 4356 | 79449086 |
Hospitalisation | 20.58 | 9.57 | 232 | 290714 | 94004 | 79359438 |
Subarachnoid haemorrhage | 20.58 | 9.57 | 36 | 290910 | 24429 | 79429013 |
Vestibular ischaemia | 20.53 | 9.57 | 6 | 290940 | 14 | 79453428 |
Acute myeloid leukaemia | 20.48 | 9.57 | 52 | 290894 | 30833 | 79422609 |
Substance dependence | 20.45 | 9.57 | 16 | 290930 | 488 | 79452954 |
Renal papillary necrosis | 20.44 | 9.57 | 15 | 290931 | 415 | 79453027 |
Hepatotoxicity | 20.43 | 9.57 | 107 | 290839 | 51245 | 79402197 |
Puncture site haematoma | 20.38 | 9.57 | 11 | 290935 | 174 | 79453268 |
Hypersomnia | 20.23 | 9.57 | 149 | 290797 | 22937 | 79430505 |
Apraxia | 20.21 | 9.57 | 37 | 290909 | 2830 | 79450612 |
Wrong patient | 20.17 | 9.57 | 14 | 290932 | 354 | 79453088 |
Lymphadenopathy | 20.05 | 9.57 | 113 | 290833 | 53134 | 79400308 |
Therapeutic response decreased | 20.04 | 9.57 | 152 | 290794 | 66701 | 79386741 |
Leukoencephalopathy | 19.91 | 9.57 | 69 | 290877 | 7860 | 79445582 |
Conversion disorder | 19.90 | 9.57 | 29 | 290917 | 1832 | 79451610 |
Hypocalcaemia | 19.87 | 9.57 | 104 | 290842 | 49820 | 79403622 |
Cutaneous T-cell dyscrasia | 19.81 | 9.57 | 8 | 290938 | 62 | 79453380 |
Hypochloraemia | 19.71 | 9.57 | 34 | 290912 | 2481 | 79450961 |
Type 2 diabetes mellitus | 19.52 | 9.57 | 125 | 290821 | 56997 | 79396445 |
Prothrombin time shortened | 19.48 | 9.57 | 39 | 290907 | 3189 | 79450253 |
Thermal burn | 19.47 | 9.57 | 64 | 290882 | 7096 | 79446346 |
Acquired amegakaryocytic thrombocytopenia | 19.45 | 9.57 | 6 | 290940 | 18 | 79453424 |
Hyperreflexia | 19.37 | 9.57 | 71 | 290875 | 8314 | 79445128 |
Purging | 19.28 | 9.57 | 7 | 290939 | 39 | 79453403 |
Sputum discoloured | 19.21 | 9.57 | 31 | 290915 | 21712 | 79431730 |
Vaginal flatulence | 19.13 | 9.57 | 34 | 290912 | 2541 | 79450901 |
Influenza | 19.13 | 9.57 | 345 | 290601 | 129261 | 79324181 |
Bladder cancer | 19.04 | 9.57 | 26 | 290920 | 19500 | 79433942 |
Chronic fatigue syndrome | 18.98 | 9.57 | 24 | 290922 | 1323 | 79452119 |
Adverse event | 18.97 | 9.57 | 135 | 290811 | 60079 | 79393363 |
Respiratory failure | 18.82 | 9.57 | 509 | 290437 | 180402 | 79273040 |
Partner stress | 18.78 | 9.57 | 13 | 290933 | 327 | 79453115 |
Drug diversion | 18.78 | 9.57 | 23 | 290923 | 1227 | 79452215 |
Rhinorrhoea | 18.76 | 9.57 | 182 | 290764 | 75892 | 79377550 |
Forced expiratory volume decreased | 18.76 | 9.57 | 3 | 290943 | 7811 | 79445631 |
Logorrhoea | 18.72 | 9.57 | 46 | 290900 | 4319 | 79449123 |
Reduced facial expression | 18.63 | 9.57 | 35 | 290911 | 2730 | 79450712 |
Body temperature increased | 18.55 | 9.57 | 91 | 290855 | 44329 | 79409113 |
Pain | 18.51 | 9.57 | 2267 | 288679 | 701535 | 78751907 |
Autoimmune disorder | 18.44 | 9.57 | 20 | 290926 | 16592 | 79436850 |
Brachial plexus injury | 18.44 | 9.57 | 9 | 290937 | 114 | 79453328 |
Cholangitis | 18.33 | 9.57 | 12 | 290934 | 12764 | 79440678 |
Tonic clonic movements | 18.26 | 9.57 | 31 | 290915 | 2233 | 79451209 |
Skin ulcer | 18.25 | 9.57 | 119 | 290827 | 54031 | 79399411 |
Prothrombin level decreased | 18.13 | 9.57 | 26 | 290920 | 1618 | 79451824 |
Blood alcohol increased | 18.13 | 9.57 | 23 | 290923 | 1272 | 79452170 |
Cardiac valve disease | 18.09 | 9.57 | 54 | 290892 | 5687 | 79447755 |
Alanine aminotransferase abnormal | 18.02 | 9.57 | 5 | 290941 | 8862 | 79444580 |
Multiple sclerosis | 17.95 | 9.57 | 141 | 290805 | 22141 | 79431301 |
Necrosis ischaemic | 17.92 | 9.57 | 21 | 290925 | 1069 | 79452373 |
Metastases to lung | 17.90 | 9.57 | 24 | 290922 | 18139 | 79435303 |
Affect lability | 17.89 | 9.57 | 85 | 290861 | 11174 | 79442268 |
Dermatitis allergic | 17.82 | 9.57 | 24 | 290922 | 18106 | 79435336 |
Loss of personal independence in daily activities | 17.80 | 9.57 | 265 | 290681 | 102315 | 79351127 |
Brain oedema | 17.74 | 9.57 | 155 | 290791 | 25108 | 79428334 |
Incoherent | 17.66 | 9.57 | 65 | 290881 | 7627 | 79445815 |
Foetal death | 17.66 | 9.57 | 67 | 290879 | 7977 | 79445465 |
Morbid thoughts | 17.63 | 9.57 | 18 | 290928 | 784 | 79452658 |
Neuropathy peripheral | 17.58 | 9.57 | 387 | 290559 | 140918 | 79312524 |
Sinus tachycardia | 17.54 | 9.57 | 209 | 290737 | 36699 | 79416743 |
Injection site pain | 17.50 | 9.57 | 351 | 290595 | 129487 | 79323955 |
Second primary malignancy | 17.39 | 9.57 | 16 | 290930 | 14334 | 79439108 |
Mental status changes | 17.37 | 9.57 | 342 | 290604 | 66617 | 79386825 |
Muscular weakness | 17.30 | 9.57 | 450 | 290496 | 160279 | 79293163 |
Injection site erythema | 17.27 | 9.57 | 192 | 290754 | 78005 | 79375437 |
Sinus bradycardia | 17.27 | 9.57 | 154 | 290792 | 25093 | 79428349 |
Drug withdrawal maintenance therapy | 17.25 | 9.57 | 7 | 290939 | 55 | 79453387 |
Drug tolerance | 17.22 | 9.57 | 70 | 290876 | 8605 | 79444837 |
Nasal polyps | 17.17 | 9.57 | 3 | 290943 | 7324 | 79446118 |
Compartment syndrome | 17.16 | 9.57 | 49 | 290897 | 5033 | 79448409 |
Myelodysplastic syndrome | 17.16 | 9.57 | 55 | 290891 | 30246 | 79423196 |
Arthritis bacterial | 17.14 | 9.57 | 6 | 290940 | 9160 | 79444282 |
Laryngeal injury | 17.01 | 9.57 | 5 | 290941 | 12 | 79453430 |
Mouth ulceration | 17.01 | 9.57 | 77 | 290869 | 38317 | 79415125 |
Bipolar I disorder | 16.97 | 9.57 | 29 | 290917 | 2100 | 79451342 |
Anamnestic reaction | 16.90 | 9.57 | 6 | 290940 | 31 | 79453411 |
Cataract | 16.89 | 9.57 | 145 | 290801 | 61975 | 79391467 |
Creatinine renal clearance decreased | 16.87 | 9.57 | 27 | 290919 | 18975 | 79434467 |
Bradycardia | 16.84 | 9.57 | 629 | 290317 | 134928 | 79318514 |
Blood cholesterol increased | 16.78 | 9.57 | 210 | 290736 | 83510 | 79369932 |
Bacterial prostatitis | 16.73 | 9.57 | 7 | 290939 | 60 | 79453382 |
Hyperthermia | 16.72 | 9.57 | 118 | 290828 | 17919 | 79435523 |
Feeling of relaxation | 16.64 | 9.57 | 9 | 290937 | 143 | 79453299 |
Squamous cell carcinoma of skin | 16.59 | 9.57 | 16 | 290930 | 14017 | 79439425 |
Mixed anxiety and depressive disorder | 16.52 | 9.57 | 13 | 290933 | 400 | 79453042 |
Learning disorder | 16.52 | 9.57 | 15 | 290931 | 564 | 79452878 |
Hypervigilance | 16.38 | 9.57 | 14 | 290932 | 485 | 79452957 |
Somnambulism | 16.34 | 9.57 | 52 | 290894 | 5669 | 79447773 |
Localised infection | 16.26 | 9.57 | 76 | 290870 | 37499 | 79415943 |
Femur fracture | 16.25 | 9.57 | 79 | 290867 | 38573 | 79414869 |
LDL/HDL ratio increased | 16.24 | 9.57 | 4 | 290942 | 3 | 79453439 |
Papillary muscle disorder | 16.24 | 9.57 | 4 | 290942 | 3 | 79453439 |
Acute graft versus host disease in skin | 16.17 | 9.57 | 4 | 290942 | 7654 | 79445788 |
Thrombocytopenia | 16.10 | 9.57 | 797 | 290149 | 264462 | 79188980 |
BK virus infection | 16.06 | 9.57 | 6 | 290940 | 8798 | 79444644 |
Self esteem decreased | 15.97 | 9.57 | 19 | 290927 | 983 | 79452459 |
Bladder dilatation | 15.77 | 9.57 | 28 | 290918 | 2091 | 79451351 |
Dyssomnia | 15.63 | 9.57 | 6 | 290940 | 40 | 79453402 |
Cerebral infarction | 15.58 | 9.57 | 100 | 290846 | 45576 | 79407866 |
Polyarthritis | 15.52 | 9.57 | 13 | 290933 | 12189 | 79441253 |
Cystitis haemorrhagic | 15.51 | 9.57 | 7 | 290939 | 9165 | 79444277 |
Tarsal tunnel syndrome | 15.51 | 9.57 | 14 | 290932 | 522 | 79452920 |
Sarcomatoid carcinoma | 15.50 | 9.57 | 6 | 290940 | 41 | 79453401 |
Feeling drunk | 15.45 | 9.57 | 45 | 290901 | 4674 | 79448768 |
Gambling disorder | 15.37 | 9.57 | 27 | 290919 | 1999 | 79451443 |
Electrocardiogram QRS complex shortened | 15.35 | 9.57 | 16 | 290930 | 714 | 79452728 |
Dyskinesia | 15.31 | 9.57 | 239 | 290707 | 44534 | 79408908 |
Product complaint | 15.22 | 9.57 | 92 | 290854 | 13257 | 79440185 |
COVID-19 pneumonia | 15.22 | 9.57 | 54 | 290892 | 28795 | 79424647 |
Disinhibition | 15.21 | 9.57 | 31 | 290915 | 2567 | 79450875 |
Burning mouth syndrome | 15.14 | 9.57 | 14 | 290932 | 539 | 79452903 |
Tendonitis | 15.13 | 9.57 | 41 | 290905 | 23789 | 79429653 |
Refusal of treatment by patient | 15.11 | 9.57 | 69 | 290877 | 8922 | 79444520 |
Faecal disimpaction | 15.11 | 9.57 | 5 | 290941 | 20 | 79453422 |
Drug screen negative | 15.09 | 9.57 | 11 | 290935 | 301 | 79453141 |
Cushingoid | 15.08 | 9.57 | 8 | 290938 | 9544 | 79443898 |
Encephalitis | 15.06 | 9.57 | 19 | 290927 | 14741 | 79438701 |
Emotional disorder | 15.06 | 9.57 | 97 | 290849 | 14290 | 79439152 |
Abdominal pain | 15.06 | 9.57 | 1220 | 289726 | 388349 | 79065093 |
Lupus-like syndrome | 15.03 | 9.57 | 17 | 290929 | 13840 | 79439602 |
Fistula | 15.01 | 9.57 | 15 | 290931 | 12925 | 79440517 |
Pulmonary tuberculosis | 14.96 | 9.57 | 5 | 290941 | 7860 | 79445582 |
Pneumonia bacterial | 14.89 | 9.57 | 30 | 290916 | 19301 | 79434141 |
Cholestasis | 14.84 | 9.57 | 270 | 290676 | 51839 | 79401603 |
Tachycardia | 14.84 | 9.57 | 792 | 290154 | 176976 | 79276466 |
Tobacco user | 14.83 | 9.57 | 16 | 290930 | 743 | 79452699 |
Negativism | 14.82 | 9.57 | 17 | 290929 | 846 | 79452596 |
Graft versus host disease | 14.66 | 9.57 | 20 | 290926 | 15006 | 79438436 |
Victim of crime | 14.63 | 9.57 | 13 | 290933 | 475 | 79452967 |
Product substitution issue | 14.60 | 9.57 | 125 | 290821 | 20131 | 79433311 |
Initial insomnia | 14.58 | 9.57 | 57 | 290889 | 6881 | 79446561 |
Eosinophil count increased | 14.54 | 9.57 | 25 | 290921 | 17080 | 79436362 |
Incision site pain | 14.52 | 9.57 | 32 | 290914 | 2798 | 79450644 |
Blood triglycerides abnormal | 14.51 | 9.57 | 13 | 290933 | 480 | 79452962 |
Osteoporosis | 14.41 | 9.57 | 127 | 290819 | 53985 | 79399457 |
Atrial fibrillation | 14.36 | 9.57 | 583 | 290363 | 197303 | 79256139 |
Bipolar disorder | 14.36 | 9.57 | 61 | 290885 | 7646 | 79445796 |
Contusion | 14.34 | 9.57 | 423 | 290523 | 148353 | 79305089 |
Neoplasm progression | 14.34 | 9.57 | 120 | 290826 | 51562 | 79401880 |
Musculoskeletal disorder | 14.30 | 9.57 | 36 | 290910 | 21412 | 79432030 |
Throat irritation | 14.30 | 9.57 | 89 | 290857 | 40857 | 79412585 |
Accident | 14.27 | 9.57 | 67 | 290879 | 8764 | 79444678 |
Alcohol withdrawal syndrome | 14.23 | 9.57 | 26 | 290920 | 1985 | 79451457 |
Needle issue | 14.21 | 9.57 | 16 | 290930 | 13052 | 79440390 |
Yawning | 14.19 | 9.57 | 21 | 290925 | 1345 | 79452097 |
Pneumatosis intestinalis | 14.19 | 9.57 | 3 | 290943 | 6394 | 79447048 |
Generalised tonic-clonic seizure | 14.12 | 9.57 | 232 | 290714 | 43678 | 79409764 |
Meningioma | 14.09 | 9.57 | 41 | 290905 | 4257 | 79449185 |
Paraesthesia oral | 14.07 | 9.57 | 125 | 290821 | 20346 | 79433096 |
Pneumonitis | 14.02 | 9.57 | 148 | 290798 | 60712 | 79392730 |
Osteonecrosis | 13.99 | 9.57 | 62 | 290884 | 31033 | 79422409 |
Libido decreased | 13.97 | 9.57 | 47 | 290899 | 5274 | 79448168 |
Angina pectoris | 13.96 | 9.57 | 121 | 290825 | 51611 | 79401831 |
Hypersensitivity vasculitis | 13.95 | 9.57 | 4 | 290942 | 6939 | 79446503 |
Weight increased | 13.95 | 9.57 | 849 | 290097 | 276537 | 79176905 |
Multiple sclerosis relapse | 13.92 | 9.57 | 243 | 290703 | 46290 | 79407152 |
Product quality issue | 13.92 | 9.57 | 187 | 290759 | 33753 | 79419689 |
Amimia | 13.90 | 9.57 | 6 | 290940 | 56 | 79453386 |
Panic reaction | 13.87 | 9.57 | 43 | 290903 | 4622 | 79448820 |
Tracheobronchitis bacterial | 13.85 | 9.57 | 3 | 290943 | 0 | 79453442 |
Bone density decreased | 13.81 | 9.57 | 17 | 290929 | 13330 | 79440112 |
Fear of injection | 13.79 | 9.57 | 5 | 290941 | 7469 | 79445973 |
Hyperinsulinism | 13.79 | 9.57 | 4 | 290942 | 9 | 79453433 |
Formication | 13.75 | 9.57 | 45 | 290901 | 4978 | 79448464 |
Hepatic cirrhosis | 13.73 | 9.57 | 73 | 290873 | 34833 | 79418609 |
Drug dose omission by device | 13.72 | 9.57 | 3 | 290943 | 6247 | 79447195 |
Cerebral congestion | 13.71 | 9.57 | 6 | 290940 | 58 | 79453384 |
Alcoholism | 13.66 | 9.57 | 37 | 290909 | 3686 | 79449756 |
Mean cell haemoglobin decreased | 13.64 | 9.57 | 3 | 290943 | 6221 | 79447221 |
Cerebral microangiopathy | 13.61 | 9.57 | 10 | 290936 | 277 | 79453165 |
Drug eruption | 13.59 | 9.57 | 99 | 290847 | 43836 | 79409606 |
Haemolysis | 13.59 | 9.57 | 16 | 290930 | 12796 | 79440646 |
Hyperacusis | 13.58 | 9.57 | 27 | 290919 | 2196 | 79451246 |
Coma scale | 13.53 | 9.57 | 6 | 290940 | 60 | 79453382 |
Hepatic cytolysis | 13.46 | 9.57 | 155 | 290791 | 26996 | 79426446 |
Hyponatraemia | 13.41 | 9.57 | 785 | 290161 | 177063 | 79276379 |
Device related infection | 13.34 | 9.57 | 72 | 290874 | 34222 | 79419220 |
Proteinuria | 13.34 | 9.57 | 67 | 290879 | 32435 | 79421007 |
Maximal voluntary ventilation abnormal | 13.33 | 9.57 | 5 | 290941 | 31 | 79453411 |
Thymus disorder | 13.31 | 9.57 | 10 | 290936 | 287 | 79453155 |
Hypertonia | 13.29 | 9.57 | 57 | 290889 | 7175 | 79446267 |
Abnormal dreams | 13.24 | 9.57 | 79 | 290867 | 11333 | 79442109 |
Palmar-plantar erythrodysaesthesia syndrome | 13.20 | 9.57 | 69 | 290877 | 33065 | 79420377 |
Graft versus host disease in skin | 13.16 | 9.57 | 3 | 290943 | 6070 | 79447372 |
Blood triglycerides decreased | 13.16 | 9.57 | 9 | 290937 | 222 | 79453220 |
Hypercapnia | 13.16 | 9.57 | 66 | 290880 | 8869 | 79444573 |
Burning sensation | 13.10 | 9.57 | 293 | 290653 | 58339 | 79395103 |
Paranoia | 13.02 | 9.57 | 118 | 290828 | 19314 | 79434128 |
Jaundice | 13.00 | 9.57 | 128 | 290818 | 53221 | 79400221 |
Foreign body | 12.95 | 9.57 | 31 | 290915 | 2863 | 79450579 |
Physical assault | 12.92 | 9.57 | 22 | 290924 | 1589 | 79451853 |
Nephrotic syndrome | 12.91 | 9.57 | 13 | 290933 | 11161 | 79442281 |
Wrong rate | 12.88 | 9.57 | 6 | 290940 | 68 | 79453374 |
Vestibular disorder | 12.87 | 9.57 | 28 | 290918 | 2427 | 79451015 |
Injection site swelling | 12.82 | 9.57 | 110 | 290836 | 47022 | 79406420 |
Hypotension | 12.81 | 9.57 | 1813 | 289133 | 438504 | 79014938 |
Cognitive disorder | 12.78 | 9.57 | 340 | 290606 | 69586 | 79383856 |
Osteomyelitis | 12.78 | 9.57 | 69 | 290877 | 32796 | 79420646 |
Cytomegalovirus test positive | 12.76 | 9.57 | 3 | 290943 | 5944 | 79447498 |
Gastric cancer | 12.76 | 9.57 | 11 | 290935 | 10168 | 79443274 |
Legal problem | 12.74 | 9.57 | 8 | 290938 | 170 | 79453272 |
Cholecystectomy | 12.73 | 9.57 | 68 | 290878 | 9364 | 79444078 |
Abdominal pain upper | 12.71 | 9.57 | 677 | 290269 | 223142 | 79230300 |
Metastases to bone | 12.70 | 9.57 | 46 | 290900 | 24381 | 79429061 |
Chloasma | 12.70 | 9.57 | 5 | 290941 | 36 | 79453406 |
Feeling hot | 12.67 | 9.57 | 148 | 290798 | 59586 | 79393856 |
Basal cell carcinoma | 12.66 | 9.57 | 82 | 290864 | 37293 | 79416149 |
Large intestine perforation | 12.65 | 9.57 | 21 | 290925 | 14546 | 79438896 |
Blood pressure increased | 12.63 | 9.57 | 636 | 290310 | 210724 | 79242718 |
Nodular rash | 12.62 | 9.57 | 10 | 290936 | 311 | 79453131 |
Myopathy | 12.59 | 9.57 | 36 | 290910 | 20527 | 79432915 |
Pneumoconiosis | 12.58 | 9.57 | 9 | 290937 | 239 | 79453203 |
Colorectal cancer | 12.57 | 9.57 | 8 | 290938 | 8639 | 79444803 |
Substance-induced mood disorder | 12.57 | 9.57 | 7 | 290939 | 118 | 79453324 |
Electroencephalogram abnormal | 12.54 | 9.57 | 46 | 290900 | 5388 | 79448054 |
Immunosuppression | 12.53 | 9.57 | 17 | 290929 | 12786 | 79440656 |
Atrioventricular block | 12.52 | 9.57 | 91 | 290855 | 13950 | 79439492 |
Pulmonary alveolar haemorrhage | 12.49 | 9.57 | 14 | 290932 | 11443 | 79441999 |
Ligament sprain | 12.43 | 9.57 | 88 | 290858 | 13376 | 79440066 |
Cardiomegaly | 12.43 | 9.57 | 149 | 290797 | 26203 | 79427239 |
Disease recurrence | 12.43 | 9.57 | 102 | 290844 | 44007 | 79409435 |
Vaginal discharge | 12.34 | 9.57 | 57 | 290889 | 7406 | 79446036 |
Torsade de pointes | 12.30 | 9.57 | 116 | 290830 | 19196 | 79434246 |
Peripheral nerve paresis | 12.25 | 9.57 | 5 | 290941 | 40 | 79453402 |
Tubulointerstitial nephritis and uveitis syndrome | 12.24 | 9.57 | 10 | 290936 | 325 | 79453117 |
Brain death | 12.23 | 9.57 | 47 | 290899 | 5630 | 79447812 |
Oesophagitis chemical | 12.15 | 9.57 | 6 | 290940 | 78 | 79453364 |
Judgement impaired | 12.11 | 9.57 | 19 | 290927 | 1281 | 79452161 |
Sickle cell anaemia with crisis | 11.98 | 9.57 | 7 | 290939 | 7915 | 79445527 |
Musculoskeletal pain | 11.97 | 9.57 | 283 | 290663 | 102071 | 79351371 |
Growth hormone deficiency | 11.97 | 9.57 | 11 | 290935 | 420 | 79453022 |
Cutaneous lymphoma | 11.96 | 9.57 | 9 | 290937 | 259 | 79453183 |
Intrusive thoughts | 11.95 | 9.57 | 12 | 290934 | 512 | 79452930 |
Anxiety disorder | 11.91 | 9.57 | 38 | 290908 | 4149 | 79449293 |
Hypokalaemia | 11.87 | 9.57 | 641 | 290305 | 143399 | 79310043 |
Hair texture abnormal | 11.86 | 9.57 | 34 | 290912 | 3500 | 79449942 |
Skin plaque | 11.86 | 9.57 | 13 | 290933 | 10732 | 79442710 |
Blood uric acid increased | 11.85 | 9.57 | 19 | 290927 | 13341 | 79440101 |
Inflammatory marker increased | 11.84 | 9.57 | 13 | 290933 | 10727 | 79442715 |
Chemical poisoning | 11.81 | 9.57 | 8 | 290938 | 194 | 79453248 |
Victim of sexual abuse | 11.80 | 9.57 | 12 | 290934 | 520 | 79452922 |
Respiratory tract infection | 11.79 | 9.57 | 117 | 290829 | 48572 | 79404870 |
Faeces soft | 11.70 | 9.57 | 8 | 290938 | 8315 | 79445127 |
Aplasia pure red cell | 11.67 | 9.57 | 7 | 290939 | 7803 | 79445639 |
Product solubility abnormal | 11.65 | 9.57 | 16 | 290930 | 956 | 79452486 |
Periorbital haematoma | 11.63 | 9.57 | 16 | 290930 | 958 | 79452484 |
Femoral artery aneurysm | 11.60 | 9.57 | 8 | 290938 | 200 | 79453242 |
Vascular purpura | 11.58 | 9.57 | 31 | 290915 | 3067 | 79450375 |
Foaming at mouth | 11.54 | 9.57 | 23 | 290923 | 1874 | 79451568 |
Gastric infection | 11.54 | 9.57 | 35 | 290911 | 3718 | 79449724 |
Suspiciousness | 11.54 | 9.57 | 13 | 290933 | 634 | 79452808 |
Pulmonary fibrosis | 11.54 | 9.57 | 104 | 290842 | 44008 | 79409434 |
Dysuria | 11.50 | 9.57 | 255 | 290691 | 50696 | 79402746 |
Product substitution | 11.46 | 9.57 | 6 | 290940 | 89 | 79453353 |
Red cell distribution width increased | 11.44 | 9.57 | 24 | 290922 | 15218 | 79438224 |
Anion gap abnormal | 11.44 | 9.57 | 13 | 290933 | 640 | 79452802 |
Seizure | 11.42 | 9.57 | 818 | 290128 | 188016 | 79265426 |
Sudden death | 11.38 | 9.57 | 129 | 290817 | 22382 | 79431060 |
Chronic sinusitis | 11.37 | 9.57 | 84 | 290862 | 12942 | 79440500 |
Vascular headache | 11.37 | 9.57 | 5 | 290941 | 49 | 79453393 |
Vasculitis | 11.33 | 9.57 | 50 | 290896 | 25052 | 79428390 |
Deformity | 11.30 | 9.57 | 11 | 290935 | 9594 | 79443848 |
Proctitis | 11.29 | 9.57 | 50 | 290896 | 6382 | 79447060 |
Epistaxis | 11.27 | 9.57 | 315 | 290631 | 111200 | 79342242 |
Cyclothymic disorder | 11.26 | 9.57 | 8 | 290938 | 210 | 79453232 |
Red blood cell count decreased | 11.25 | 9.57 | 145 | 290801 | 57368 | 79396074 |
Hepatitis acute | 11.25 | 9.57 | 96 | 290850 | 15446 | 79437996 |
Central nervous system necrosis | 11.24 | 9.57 | 9 | 290937 | 284 | 79453158 |
Disability | 11.21 | 9.57 | 29 | 290917 | 17091 | 79436351 |
Myocardial infarction | 11.21 | 9.57 | 553 | 290393 | 183576 | 79269866 |
Face injury | 11.11 | 9.57 | 34 | 290912 | 3630 | 79449812 |
Biliary dyskinesia | 11.11 | 9.57 | 27 | 290919 | 2518 | 79450924 |
Therapeutic response shortened | 11.07 | 9.57 | 26 | 290920 | 15837 | 79437605 |
Cystitis | 11.05 | 9.57 | 131 | 290815 | 52601 | 79400841 |
Peripheral circulatory failure | 11.03 | 9.57 | 17 | 290929 | 1129 | 79452313 |
Muscle rigidity | 11 | 9.57 | 116 | 290830 | 19766 | 79433676 |
Post-traumatic stress disorder | 11 | 9.57 | 41 | 290905 | 4840 | 79448602 |
Hypophagia | 10.99 | 9.57 | 109 | 290837 | 45258 | 79408184 |
Sinus arrhythmia | 10.99 | 9.57 | 24 | 290922 | 2086 | 79451356 |
Hypoxic-ischaemic encephalopathy | 10.98 | 9.57 | 57 | 290889 | 7763 | 79445679 |
Blood creatine phosphokinase | 10.93 | 9.57 | 7 | 290939 | 154 | 79453288 |
Muscle spasms | 10.93 | 9.57 | 759 | 290187 | 173971 | 79279471 |
Neuroglycopenia | 10.89 | 9.57 | 11 | 290935 | 473 | 79452969 |
Pericardial effusion | 10.83 | 9.57 | 112 | 290834 | 46125 | 79407317 |
Impulsive behaviour | 10.82 | 9.57 | 29 | 290917 | 2871 | 79450571 |
Oesophageal food impaction | 10.81 | 9.57 | 10 | 290936 | 385 | 79453057 |
Hallucination, olfactory | 10.81 | 9.57 | 11 | 290935 | 477 | 79452965 |
Oedematous pancreatitis | 10.78 | 9.57 | 17 | 290929 | 1151 | 79452291 |
Acute myocardial infarction | 10.76 | 9.57 | 207 | 290739 | 76829 | 79376613 |
Device malfunction | 10.75 | 9.57 | 41 | 290905 | 21407 | 79432035 |
Infective pulmonary exacerbation of cystic fibrosis | 10.73 | 9.57 | 19 | 290927 | 12832 | 79440610 |
Rhinovirus infection | 10.71 | 9.57 | 8 | 290938 | 7945 | 79445497 |
Vagus nerve disorder | 10.71 | 9.57 | 5 | 290941 | 57 | 79453385 |
Sciatica | 10.70 | 9.57 | 74 | 290872 | 33148 | 79420294 |
Benzodiazepine drug level increased | 10.69 | 9.57 | 8 | 290938 | 228 | 79453214 |
Anal fistula | 10.69 | 9.57 | 6 | 290940 | 6938 | 79446504 |
Sedation complication | 10.68 | 9.57 | 26 | 290920 | 15643 | 79437799 |
Tremor neonatal | 10.58 | 9.57 | 3 | 290943 | 6 | 79453436 |
Benign mesenteric neoplasm | 10.58 | 9.57 | 3 | 290943 | 6 | 79453436 |
Progressive multifocal leukoencephalopathy | 10.58 | 9.57 | 39 | 290907 | 20561 | 79432881 |
Nephrolithiasis | 10.56 | 9.57 | 134 | 290812 | 53157 | 79400285 |
Conjunctivitis | 10.56 | 9.57 | 53 | 290893 | 25662 | 79427780 |
X-ray abnormal | 10.54 | 9.57 | 4 | 290942 | 5809 | 79447633 |
Retrograde amnesia | 10.53 | 9.57 | 12 | 290934 | 593 | 79452849 |
Labelled drug-food interaction medication error | 10.51 | 9.57 | 7 | 290939 | 165 | 79453277 |
Myotonia | 10.49 | 9.57 | 8 | 290938 | 235 | 79453207 |
Injury | 10.46 | 9.57 | 363 | 290583 | 77133 | 79376309 |
Anion gap | 10.45 | 9.57 | 24 | 290922 | 2157 | 79451285 |
Electrocardiogram ST-T change | 10.39 | 9.57 | 20 | 290926 | 1589 | 79451853 |
Thermal burns of eye | 10.38 | 9.57 | 6 | 290940 | 109 | 79453333 |
Vasoplegia syndrome | 10.37 | 9.57 | 33 | 290913 | 3597 | 79449845 |
Visceral congestion | 10.37 | 9.57 | 15 | 290931 | 941 | 79452501 |
Polyneuropathy | 10.36 | 9.57 | 49 | 290897 | 24102 | 79429340 |
Pre-existing condition improved | 10.34 | 9.57 | 44 | 290902 | 5519 | 79447923 |
Erythrodermic psoriasis | 10.32 | 9.57 | 21 | 290925 | 1737 | 79451705 |
Uterine perforation | 10.32 | 9.57 | 48 | 290898 | 6255 | 79447187 |
Intestinal perforation | 10.31 | 9.57 | 31 | 290915 | 17395 | 79436047 |
Immune thrombocytopenia | 10.31 | 9.57 | 32 | 290914 | 17773 | 79435669 |
Victim of homicide | 10.29 | 9.57 | 7 | 290939 | 171 | 79453271 |
Skin abrasion | 10.21 | 9.57 | 84 | 290862 | 13372 | 79440070 |
Pneumonia viral | 10.19 | 9.57 | 11 | 290935 | 9147 | 79444295 |
Deafness neurosensory | 10.19 | 9.57 | 51 | 290895 | 6847 | 79446595 |
Rales | 10.18 | 9.57 | 38 | 290908 | 19963 | 79433479 |
Death of relative | 10.17 | 9.57 | 8 | 290938 | 246 | 79453196 |
Nocardiosis | 10.14 | 9.57 | 4 | 290942 | 5675 | 79447767 |
Bundle branch block right | 10.08 | 9.57 | 73 | 290873 | 11178 | 79442264 |
Proctalgia | 10.07 | 9.57 | 13 | 290933 | 9988 | 79443454 |
Purpura senile | 10.06 | 9.57 | 11 | 290935 | 519 | 79452923 |
Coma scale abnormal | 10.02 | 9.57 | 60 | 290886 | 8618 | 79444824 |
Swollen tongue | 10.02 | 9.57 | 103 | 290843 | 42467 | 79410975 |
Ear infection | 9.98 | 9.57 | 79 | 290867 | 34353 | 79419089 |
Metastases to lymph nodes | 9.98 | 9.57 | 14 | 290932 | 10383 | 79443059 |
Phobia | 9.98 | 9.57 | 10 | 290936 | 426 | 79453016 |
Sepsis syndrome | 9.97 | 9.57 | 19 | 290927 | 1498 | 79451944 |
Beta haemolytic streptococcal infection | 9.97 | 9.57 | 23 | 290923 | 2074 | 79451368 |
Enterocolitis | 9.96 | 9.57 | 24 | 290922 | 14488 | 79438954 |
Skin reaction | 9.94 | 9.57 | 28 | 290918 | 16040 | 79437402 |
Lung neoplasm malignant | 9.92 | 9.57 | 60 | 290886 | 27732 | 79425710 |
Language disorder | 9.91 | 9.57 | 30 | 290916 | 3184 | 79450258 |
Enterococcal infection | 9.90 | 9.57 | 27 | 290919 | 15633 | 79437809 |
Laryngitis | 9.88 | 9.57 | 28 | 290918 | 16011 | 79437431 |
Crime | 9.86 | 9.57 | 5 | 290941 | 69 | 79453373 |
Gallbladder disorder | 9.85 | 9.57 | 111 | 290835 | 19229 | 79434213 |
Thrombotic microangiopathy | 9.83 | 9.57 | 39 | 290907 | 20130 | 79433312 |
Tongue biting | 9.79 | 9.57 | 23 | 290923 | 2098 | 79451344 |
Methaemoglobinaemia | 9.78 | 9.57 | 4 | 290942 | 5553 | 79447889 |
Haematemesis | 9.77 | 9.57 | 133 | 290813 | 52131 | 79401311 |
Gallbladder hypofunction | 9.77 | 9.57 | 11 | 290935 | 536 | 79452906 |
Faecal calprotectin increased | 9.74 | 9.57 | 4 | 290942 | 5537 | 79447905 |
Carotid pulse abnormal | 9.73 | 9.57 | 3 | 290943 | 9 | 79453433 |
Blood calcium decreased | 9.70 | 9.57 | 72 | 290874 | 31747 | 79421695 |
Normal newborn | 9.67 | 9.57 | 7 | 290939 | 7065 | 79446377 |
Prothrombin level increased | 9.65 | 9.57 | 10 | 290936 | 443 | 79452999 |
Akathisia | 9.65 | 9.57 | 82 | 290864 | 13177 | 79440265 |
Photophobia | 9.65 | 9.57 | 116 | 290830 | 20412 | 79433030 |
Brain abscess | 9.63 | 9.57 | 3 | 290943 | 4933 | 79448509 |
Performance status decreased | 9.60 | 9.57 | 46 | 290900 | 6067 | 79447375 |
Staphylococcal sepsis | 9.60 | 9.57 | 25 | 290921 | 14701 | 79438741 |
None
Source | Code | Description |
---|---|---|
ATC | N05BA12 | NERVOUS SYSTEM PSYCHOLEPTICS ANXIOLYTICS Benzodiazepine derivatives |
FDA CS | M0002356 | Benzodiazepines |
CHEBI has role | CHEBI:35474 | anti-anxiety agents |
CHEBI has role | CHEBI:35623 | anticonvulsants |
CHEBI has role | CHEBI:35703 | Xenobiotic |
CHEBI has role | CHEBI:35717 | hypnotics |
CHEBI has role | CHEBI:51371 | muscle relaxants |
CHEBI has role | CHEBI:51373 | gamma-aminobutyric acid receptor agonist |
MeSH PA | D014151 | Anti-Anxiety Agents |
MeSH PA | D002491 | Central Nervous System Agents |
MeSH PA | D002492 | Central Nervous System Depressants |
MeSH PA | D018682 | GABA Agents |
MeSH PA | D018757 | GABA Modulators |
MeSH PA | D006993 | Hypnotics and Sedatives |
MeSH PA | D018377 | Neurotransmitter Agents |
MeSH PA | D011619 | Psychotropic Drugs |
MeSH PA | D014149 | Tranquilizing Agents |
FDA EPC | N0000175694 | Benzodiazepine |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Generalized anxiety disorder | indication | 21897009 | DOID:14320 |
Anxiety | indication | 48694002 | |
Mixed anxiety and depressive disorder | indication | 231504006 | |
Panic disorder | indication | 371631005 | DOID:594 |
Insomnia | off-label use | 193462001 | |
Suicidal thoughts | contraindication | 6471006 | |
Asthenia | contraindication | 13791008 | |
Alcohol intoxication | contraindication | 25702006 | |
Depressive disorder | contraindication | 35489007 | |
Substance abuse | contraindication | 66214007 | |
Sleep apnea | contraindication | 73430006 | DOID:0050847 |
Open-angle glaucoma | contraindication | 84494001 | DOID:1067 |
Kidney disease | contraindication | 90708001 | DOID:557 |
Disease of liver | contraindication | 235856003 | DOID:409 |
Syncope | contraindication | 271594007 | |
Pregnancy, function | contraindication | 289908002 | |
Angle-closure glaucoma | contraindication | 392291006 | DOID:13550 |
Breastfeeding (mother) | contraindication | 413712001 | |
Chronic lung disease | contraindication | 413839001 | |
Obesity | contraindication | 414916001 | DOID:9970 |
Central nervous system depression | contraindication | 418072004 | |
Smokes tobacco daily | contraindication | 449868002 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 6.15 | Basic |
pKa2 | 4.9 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
GABA-A receptor alpha-5/beta-3/gamma-2 | Ion channel | POSITIVE ALLOSTERIC MODULATOR | EC50 | 8 | WOMBAT-PK | CHEMBL | |||
GABA-A receptor alpha-1/beta-2/gamma-2 | Ion channel | POSITIVE ALLOSTERIC MODULATOR | EC50 | 7.43 | WOMBAT-PK | CHEMBL | |||
GABA-A receptor alpha-2/beta-3/gamma-2 | Ion channel | POSITIVE ALLOSTERIC MODULATOR | EC50 | 7.92 | WOMBAT-PK | CHEMBL | |||
GABA-A receptor alpha-3/beta-3/gamma-2 | Ion channel | POSITIVE ALLOSTERIC MODULATOR | EC50 | 7.16 | WOMBAT-PK | CHEMBL | |||
Cytochrome P450 3A4 | Enzyme | Ki | 3.85 | WOMBAT-PK | |||||
Platelet-activating factor receptor | GPCR | Ki | 5.46 | PDSP | |||||
Bromodomain-containing protein 4 | Unclassified | Kd | 5.61 | CHEMBL | |||||
Cholecystokinin receptor type A | GPCR | IC50 | 4.19 | CHEMBL |
ID | Source |
---|---|
D00225 | KEGG_DRUG |
202363 | RXNORM |
C0002333 | UMLSCUI |
CHEBI:2611 | CHEBI |
08H | PDB_CHEM_ID |
CHEMBL661 | ChEMBL_ID |
DB00404 | DRUGBANK_ID |
D000525 | MESH_DESCRIPTOR_UI |
2118 | PUBCHEM_CID |
7111 | IUPHAR_LIGAND_ID |
3426 | INN_ID |
YU55MQ3IZY | UNII |
111127002 | SNOMEDCT_US |
386983007 | SNOMEDCT_US |
4018074 | VANDF |
1327 | MMSL |
1885 | MMSL |
4153 | MMSL |
d00168 | MMSL |
001464 | NDDF |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Xanax | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0009-0029 | TABLET | 0.25 mg | ORAL | NDA | 37 sections |
Xanax | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0009-0029 | TABLET | 0.25 mg | ORAL | NDA | 37 sections |
Xanax | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0009-0055 | TABLET | 0.50 mg | ORAL | NDA | 37 sections |
Xanax | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0009-0055 | TABLET | 0.50 mg | ORAL | NDA | 37 sections |
Xanax XR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0009-0057 | TABLET, EXTENDED RELEASE | 0.50 mg | ORAL | NDA | 38 sections |
Xanax XR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0009-0057 | TABLET, EXTENDED RELEASE | 0.50 mg | ORAL | NDA | 38 sections |
Xanax XR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0009-0057 | TABLET, EXTENDED RELEASE | 0.50 mg | ORAL | NDA | 38 sections |
Xanax XR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0009-0059 | TABLET, EXTENDED RELEASE | 1 mg | ORAL | NDA | 38 sections |
Xanax XR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0009-0059 | TABLET, EXTENDED RELEASE | 1 mg | ORAL | NDA | 38 sections |
Xanax XR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0009-0059 | TABLET, EXTENDED RELEASE | 1 mg | ORAL | NDA | 38 sections |
Xanax XR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0009-0066 | TABLET, EXTENDED RELEASE | 2 mg | ORAL | NDA | 38 sections |
Xanax XR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0009-0066 | TABLET, EXTENDED RELEASE | 2 mg | ORAL | NDA | 38 sections |
Xanax XR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0009-0066 | TABLET, EXTENDED RELEASE | 2 mg | ORAL | NDA | 38 sections |
Xanax XR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0009-0068 | TABLET, EXTENDED RELEASE | 3 mg | ORAL | NDA | 38 sections |
Xanax XR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0009-0068 | TABLET, EXTENDED RELEASE | 3 mg | ORAL | NDA | 38 sections |
Xanax XR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0009-0068 | TABLET, EXTENDED RELEASE | 3 mg | ORAL | NDA | 38 sections |
Xanax | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0009-0090 | TABLET | 1 mg | ORAL | NDA | 37 sections |
Xanax | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0009-0090 | TABLET | 1 mg | ORAL | NDA | 37 sections |
Xanax | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0009-0094 | TABLET | 2 mg | ORAL | NDA | 37 sections |
Xanax | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0009-0094 | TABLET | 2 mg | ORAL | NDA | 37 sections |
Alprazolam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-3068 | SOLUTION, CONCENTRATE | 1 mg | ORAL | ANDA | 34 sections |
Alprazolam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-3068 | SOLUTION, CONCENTRATE | 1 mg | ORAL | ANDA | 34 sections |
Alprazolam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0228-2027 | TABLET | 0.25 mg | ORAL | ANDA | 29 sections |
Alprazolam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0228-2027 | TABLET | 0.25 mg | ORAL | ANDA | 29 sections |
Alprazolam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0228-2027 | TABLET | 0.25 mg | ORAL | ANDA | 29 sections |
Alprazolam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0228-2029 | TABLET | 0.50 mg | ORAL | ANDA | 29 sections |
Alprazolam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0228-2029 | TABLET | 0.50 mg | ORAL | ANDA | 29 sections |
Alprazolam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0228-2029 | TABLET | 0.50 mg | ORAL | ANDA | 29 sections |
Alprazolam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0228-2031 | TABLET | 1 mg | ORAL | ANDA | 29 sections |
Alprazolam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0228-2031 | TABLET | 1 mg | ORAL | ANDA | 29 sections |