alprazolam 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
diazepam derivatives	136	28981-97-7

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: xanax alprazolam alprozolam alzolam	A triazolobenzodiazepine compound with antianxiety and sedative-hypnotic actions, that is efficacious in the treatment of PANIC DISORDERS, with or without AGORAPHOBIA, and in generalized ANXIETY DISORDERS. (From AMA Drug Evaluations Annual, 1994, p238) Molecular weight: 308.77 Formula: C17H13ClN4 CLOGP: 2.56 LIPINSKI: 0 HAC: 4 HDO: 0 TPSA: 43.07 ALOGS: -3.98 ROTB: 1 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

xanax
alprazolam
alprozolam
alzolam

A triazolobenzodiazepine compound with antianxiety and sedative-hypnotic actions, that is efficacious in the treatment of PANIC DISORDERS, with or without AGORAPHOBIA, and in generalized ANXIETY DISORDERS. (From AMA Drug Evaluations Annual, 1994, p238)

Molecular weight: 308.77
Formula: C17H13ClN4
CLOGP: 2.56
LIPINSKI: 0
HAC: 4
HDO: 0
TPSA: 43.07
ALOGS: -3.98
ROTB: 1

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
1	mg	O

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	1	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	0.07 mg/mL	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	20 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	0.46 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability)	88 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution)	0.80 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	0.74 mL/min/kg	Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)	0.29 %	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	12 hours	Lombardo F, Berellini G, Obach RS

Approvals:

Date	Agency	Company	Orphan
Oct. 16, 1981	FDA	PHARMACIA AND UPJOHN

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug abuse	5353.45	9.74	3303	218035	56543	50327243
Completed suicide	3822.37	9.74	3725	217613	128164	50255622
Sopor	1862.63	9.74	1132	220206	18747	50365039
Toxicity to various agents	1645.35	9.74	3158	218180	209341	50174445
Respiratory arrest	1279.06	9.74	1056	220282	28953	50354833
Poisoning	1090.69	9.74	679	220659	11750	50372036
Suicide attempt	949.50	9.74	1151	220187	50581	50333205
Cardio-respiratory arrest	866.09	9.74	1122	220216	52770	50331016
Intentional overdose	815.02	9.74	1176	220162	61328	50322458
Cardiac arrest	766.22	9.74	1339	219999	82312	50301474
Drug dependence	638.02	9.74	594	220744	19165	50364621
Coma	590.34	9.74	963	220375	55916	50327870
Poisoning deliberate	584.68	9.74	388	220950	7524	50376262
Overdose	566.33	9.74	1308	220030	98419	50285367
Pemphigus	507.71	9.74	3	221335	120163	50263623
Contraindicated product administered	484.42	9.74	46	221292	148912	50234874
Synovitis	449.89	9.74	22	221316	123843	50259943
Somnolence	414.02	9.74	1553	219785	153432	50230354
Intentional self-injury	403.96	9.74	502	220836	22610	50361176
Drug intolerance	391.38	9.74	237	221101	218867	50164919
Intentional product misuse	385.30	9.74	715	220623	46019	50337767
Treatment failure	382.02	9.74	70	221268	137567	50246219
Hand deformity	379.93	9.74	13	221325	100186	50283600
Systemic lupus erythematosus	370.49	9.74	81	221257	140541	50243245
Joint swelling	355.03	9.74	330	221008	244956	50138830
Infusion related reaction	354.28	9.74	149	221189	169408	50214378
Rheumatoid arthritis	329.52	9.74	243	221095	202307	50181479
Drug ineffective	329.12	9.74	2171	219167	817162	49566624
Glossodynia	303.52	9.74	67	221271	115502	50268284
Arthropathy	298.77	9.74	159	221179	157747	50226039
Anti-cyclic citrullinated peptide antibody positive	287.56	9.74	4	221334	70583	50313203
Off label use	283.57	9.74	1093	220245	473333	49910453
Anxiety	282.45	9.74	1526	219812	176080	50207706
Maternal exposure during pregnancy	273.93	9.74	181	221157	159597	50224189
Pericarditis	267.50	9.74	20	221318	78669	50305117
Lower respiratory tract infection	258.61	9.74	51	221287	95150	50288636
Depression	250.01	9.74	1402	219936	164021	50219765
Bradyphrenia	244.37	9.74	208	221130	5944	50377842
Alopecia	232.14	9.74	450	220888	244597	50139189
Suicidal ideation	230.24	9.74	646	220692	54739	50329047
Drug withdrawal syndrome	226.08	9.74	399	220939	24682	50359104
Swelling	222.22	9.74	334	221004	200538	50183248
Substance abuse	187.93	9.74	151	221187	3973	50379813
Mydriasis	182.74	9.74	229	221109	10398	50373388
Exposure via ingestion	182.20	9.74	127	221211	2676	50381110
Panic attack	179.90	9.74	312	221026	19030	50364756
Discomfort	177.42	9.74	129	221209	108251	50275535
Wound	177.02	9.74	123	221215	105671	50278115
Therapeutic product effect decreased	176.25	9.74	201	221137	135849	50247937
Withdrawal syndrome	174.51	9.74	292	221046	17298	50366488
Death	173.69	9.74	2179	219159	323200	50060586
Product use issue	173.65	9.74	240	221098	149235	50234551
Hypersensitivity	168.67	9.74	438	220900	214723	50169063
Abdominal discomfort	168.56	9.74	489	220849	231152	50152634
Helicobacter infection	167.87	9.74	13	221325	49689	50334097
Nasopharyngitis	165.19	9.74	375	220963	192552	50191234
Infection	155.63	9.74	327	221011	172627	50211159
Hepatic enzyme increased	152.25	9.74	228	221110	137152	50246634
Arthralgia	152.04	9.74	1210	220128	437492	49946294
Agitation	148.98	9.74	543	220795	52841	50330945
Peripheral swelling	142.42	9.74	445	220893	205491	50178295
Rash	140.53	9.74	1231	220107	436240	49947546
Loss of consciousness	139.08	9.74	856	220482	103497	50280289
Prescription form tampering	136.75	9.74	61	221277	507	50383279
Folliculitis	130.40	9.74	11	221327	39214	50344572
Drug use disorder	126.40	9.74	106	221232	2966	50380820
Tremor	126.16	9.74	898	220440	114005	50269781
Sleep disorder due to general medical condition, insomnia type	119.43	9.74	4	221334	31443	50352343
Victim of chemical submission	113.86	9.74	43	221295	220	50383566
Muscle injury	109.29	9.74	16	221322	37095	50346691
Insomnia	106.67	9.74	1202	220136	173663	50210123
Therapeutic product effect incomplete	100.27	9.74	153	221185	91362	50292424
C-reactive protein abnormal	94.68	9.74	7	221331	27802	50355984
Disturbance in attention	91.06	9.74	322	221016	30864	50352922
Impaired healing	88.28	9.74	105	221233	69681	50314105
Bradykinesia	86.07	9.74	96	221242	3847	50379939
Hepatocellular injury	85.52	9.74	279	221059	25668	50358118
Musculoskeletal stiffness	85	9.74	283	221055	128198	50255588
General physical health deterioration	82.85	9.74	331	221007	142103	50241683
Fall	81.18	9.74	1977	219361	332955	50050831
Drug hypersensitivity	80.51	9.74	706	220632	250304	50133482
Accidental overdose	80.31	9.74	227	221111	19306	50364480
C-reactive protein increased	79.91	9.74	104	221234	66370	50317416
Nervousness	79.44	9.74	284	221054	27367	50356419
Gastrointestinal disorder	78.02	9.74	187	221151	94269	50289517
Drug screen positive	78.02	9.74	85	221253	3317	50380469
Crying	77.90	9.74	231	221107	20185	50363601
Pyrexia	77.27	9.74	1184	220154	379019	50004767
Alcohol abuse	76.99	9.74	65	221273	1836	50381950
Memory impairment	76.73	9.74	602	220736	78758	50305028
Feeling abnormal	76.64	9.74	863	220475	124629	50259157
Sinusitis	72.86	9.74	442	220896	170116	50213670
Irritable bowel syndrome	72.16	9.74	71	221267	51370	50332416
Miosis	71.10	9.74	111	221227	6199	50377587
Macular degeneration	71.08	9.74	179	221159	14209	50369577
Drug abuser	70.75	9.74	74	221264	2754	50381032
Altered state of consciousness	69.00	9.74	232	221106	21678	50362108
Febrile neutropenia	68.17	9.74	210	221128	97457	50286329
Depressed level of consciousness	67.79	9.74	424	220914	51529	50332257
Confusional state	67.65	9.74	1166	220172	184762	50199024
Suspected suicide	65.67	9.74	98	221240	5259	50378527
Disorientation	65.37	9.74	318	221020	35166	50348620
Stomatitis	65.13	9.74	226	221112	101118	50282668
Hypokinesia	64.60	9.74	156	221182	12061	50371725
Blister	63.72	9.74	178	221160	85240	50298546
Knee arthroplasty	63.55	9.74	39	221299	35807	50347979
Cough	61.42	9.74	717	220621	240547	50143239
Rheumatic fever	61.18	9.74	3	221335	16864	50366922
Abnormal behaviour	60.88	9.74	207	221131	19451	50364335
Ill-defined disorder	58.30	9.74	93	221245	54561	50329225
Dependence	57.88	9.74	55	221283	1820	50381966
Pain	57.64	9.74	2014	219324	576889	49806897
Amnesia	57.09	9.74	348	220990	41912	50341874
Pneumonia	56.56	9.74	1243	220095	377158	50006628
Exposure during pregnancy	55.73	9.74	306	221032	120709	50263077
Hip arthroplasty	55.51	9.74	32	221306	30397	50353389
Drug resistance	54.07	9.74	9	221329	18980	50364806
Irritability	53.99	9.74	257	221081	28169	50355617
Product use in unapproved indication	52.71	9.74	294	221044	115525	50268261
Vertigo	52.21	9.74	397	220941	51435	50332351
Urinary retention	50.62	9.74	238	221100	25952	50357834
Homicide	50.47	9.74	27	221311	345	50383441
Aggression	50.05	9.74	204	221134	20912	50362874
Euphoric mood	46.62	9.74	72	221266	3983	50379803
Hallucination, auditory	46.39	9.74	127	221211	10601	50373185
Psychomotor skills impaired	46.34	9.74	51	221287	2013	50381773
Condition aggravated	46.03	9.74	970	220368	296088	50087698
Abnormal dreams	45.63	9.74	116	221222	9261	50374525
Anhedonia	45.50	9.74	117	221221	9407	50374379
Hyponatraemia	45.30	9.74	630	220708	95509	50288277
Wrong patient received product	45.27	9.74	46	221292	1654	50382132
Malignant neoplasm progression	44.38	9.74	151	221187	67973	50315813
Myelosuppression	44.36	9.74	4	221334	13513	50370273
Rheumatoid nodule	43.94	9.74	3	221335	12732	50371054
Thinking abnormal	43.12	9.74	115	221223	9452	50374334
Renal impairment	42.60	9.74	178	221160	75483	50308303
Neutropenic sepsis	41.88	9.74	6	221332	14141	50369645
Mania	41.15	9.74	123	221215	10793	50372993
Neutropenia	41.08	9.74	431	220907	147534	50236252
Mobility decreased	40.85	9.74	195	221143	79753	50304033
Mental disorder	40.44	9.74	197	221141	21794	50361992
Delirium	40.42	9.74	296	221042	37896	50345890
Respiratory depression	40.34	9.74	130	221208	11880	50371906
Bradypnoea	40.24	9.74	58	221280	3016	50380770
Psychomotor hyperactivity	40.11	9.74	110	221228	9191	50374595
Anger	39.28	9.74	124	221214	11209	50372577
Hallucinations, mixed	39.21	9.74	67	221271	4036	50379750
Live birth	38.31	9.74	12	221326	16396	50367390
Alcohol poisoning	37.88	9.74	43	221295	1757	50382029
Sepsis	37.79	9.74	385	220953	132540	50251246
Mucosal inflammation	37.66	9.74	74	221264	40068	50343718
Hyperhidrosis	37.38	9.74	574	220764	88852	50294934
Nightmare	37.01	9.74	154	221184	15932	50367854
Product complaint	36.62	9.74	122	221216	11344	50372442
Premature delivery	36.36	9.74	30	221308	23633	50360153
Drug interaction	36.01	9.74	1135	220203	198486	50185300
Cytomegalovirus infection	35.55	9.74	17	221321	17945	50365841
Red blood cell sedimentation rate increased	35.36	9.74	46	221292	29370	50354416
Substance use disorder	35.24	9.74	14	221324	84	50383702
Chemical submission	35.14	9.74	17	221321	173	50383613
Blood pressure diastolic decreased	34.59	9.74	15	221323	16766	50367020
Compartment syndrome	34.53	9.74	43	221295	1939	50381847
Bone erosion	34.50	9.74	5	221333	11682	50372104
Emotional distress	34.36	9.74	229	221109	28434	50355352
Neutrophil count decreased	34.25	9.74	96	221242	45930	50337856
Intentional product use issue	34.04	9.74	197	221141	76721	50307065
Serotonin syndrome	33.68	9.74	204	221134	24509	50359277
Head injury	33.20	9.74	199	221139	23821	50359965
Dysphoria	33.17	9.74	68	221270	4706	50379080
Hallucination	32.71	9.74	330	221008	46327	50337459
Therapy non-responder	32.62	9.74	114	221224	50908	50332878
Housebound	32.35	9.74	17	221321	209	50383577
Renal papillary necrosis	32	9.74	17	221321	214	50383572
Dysarthria	31.97	9.74	276	221062	37127	50346659
Road traffic accident	31.92	9.74	199	221139	24153	50359633
Impaired driving ability	31.86	9.74	60	221278	3901	50379885
Pancytopenia	31.68	9.74	226	221112	83804	50299982
Cholecystitis chronic	30.99	9.74	103	221235	9566	50374220
Immobilisation prolonged	30.92	9.74	13	221325	92	50383694
Arthritis	30.89	9.74	237	221101	86484	50297302
Persistent genital arousal disorder	30.61	9.74	17	221321	235	50383551
Adverse drug reaction	30.41	9.74	131	221207	55091	50328695
Adjustment disorder with mixed anxiety and depressed mood	29.93	9.74	12	221326	74	50383712
Obsessive-compulsive disorder	29.91	9.74	53	221285	3287	50380499
Skin ulcer	29.88	9.74	69	221269	35249	50348537
Speech disorder	29.70	9.74	261	221077	35287	50348499
Medication error	29.61	9.74	264	221074	35840	50347946
Sedation	29.45	9.74	232	221106	30378	50353408
Drug detoxification	29.42	9.74	14	221324	137	50383649
Hallucination, visual	29.39	9.74	147	221191	16435	50367351
Accidental death	29.06	9.74	37	221301	1707	50382079
Fear	28.69	9.74	133	221205	14416	50369370
Sluggishness	28.50	9.74	61	221277	4352	50379434
Multiple injuries	28.46	9.74	36	221302	1650	50382136
Electrocardiogram QT prolonged	28.18	9.74	349	220989	51537	50332249
Psoriatic arthropathy	28.14	9.74	108	221230	46924	50336862
Blood pressure systolic increased	27.84	9.74	72	221266	35377	50348409
Psychomotor retardation	27.77	9.74	52	221286	3366	50380420
Dyspnoea	27.38	9.74	2044	219294	545564	49838222
Femur fracture	27.24	9.74	79	221259	37385	50346401
Fatigue	27.12	9.74	2697	218641	704904	49678882
Suspected counterfeit product	26.95	9.74	17	221321	301	50383485
Drug tolerance decreased	26.85	9.74	4	221334	9156	50374630
Panic disorder	26.63	9.74	41	221297	2262	50381524
Pruritus	26.61	9.74	993	220345	282575	50101211
Bipolar I disorder	26.56	9.74	33	221305	1485	50382301
Wheezing	26.35	9.74	161	221177	61886	50321900
Device expulsion	26.29	9.74	54	221284	28768	50355018
Suicidal behaviour	26.22	9.74	41	221297	2293	50381493
Extrapyramidal disorder	25.77	9.74	111	221227	11659	50372127
Bradycardia	25.58	9.74	410	220928	64016	50319770
COVID-19	25.51	9.74	111	221227	46551	50337235
Blood pressure diastolic abnormal	25.43	9.74	5	221333	9356	50374430
Hypotension	25.12	9.74	1265	220073	234204	50149582
Inflammation	25.05	9.74	146	221192	56766	50327020
Feeling of despair	24.86	9.74	37	221301	1981	50381805
Poverty of speech	24.34	9.74	16	221322	305	50383481
Post-traumatic stress disorder	23.89	9.74	56	221282	4247	50379539
Respiratory acidosis	23.75	9.74	69	221269	5959	50377827
Hyponatraemic encephalopathy	23.65	9.74	14	221324	220	50383566
Anaphylactic reaction	23.62	9.74	139	221199	53916	50329870
Cholestasis	23.61	9.74	191	221147	25210	50358576
Injury	23.59	9.74	322	221016	48603	50335183
Stress	23.52	9.74	348	220990	53445	50330341
Injection site erythema	23.42	9.74	212	221126	74724	50309062
Hypersomnia	23.20	9.74	130	221208	15184	50368602
Muscle spasms	23.18	9.74	716	220622	124837	50258949
Bronchiectasis	23.17	9.74	8	221330	10275	50373511
Urticaria	22.77	9.74	414	220924	129147	50254639
Obstructive airways disorder	22.65	9.74	21	221317	15631	50368155
Bipolar disorder	22.57	9.74	73	221265	6684	50377102
Pregnancy	22.52	9.74	61	221277	29516	50354270
Transplant rejection	22.48	9.74	7	221331	9602	50374184
Blood creatinine increased	22.29	9.74	219	221119	75941	50307845
Blood pressure fluctuation	22.25	9.74	81	221257	35742	50348044
Anticholinergic syndrome	22.24	9.74	33	221305	1762	50382024
Seizure	22.23	9.74	674	220664	117200	50266586
Benzodiazepine drug level abnormal	22.18	9.74	5	221333	0	50383786
Inadequate analgesia	22.15	9.74	40	221298	2518	50381268
Foot deformity	22.12	9.74	31	221307	19179	50364607
Apathy	22.08	9.74	78	221260	7470	50376316
Necrosis ischaemic	21.97	9.74	22	221316	777	50383009
Tonic clonic movements	21.81	9.74	27	221311	1210	50382576
Herpes zoster	21.80	9.74	201	221137	70585	50313201
Grip strength decreased	21.75	9.74	13	221325	12108	50371678
Liver function test increased	21.68	9.74	50	221288	25556	50358230
Drug withdrawal syndrome neonatal	21.60	9.74	33	221305	1808	50381978
Affect lability	21.38	9.74	87	221251	8911	50374875
Hallucination, gustatory	21.37	9.74	9	221329	64	50383722
Cardiac failure	21.28	9.74	221	221117	75819	50307967
Multiple sclerosis	21.21	9.74	158	221180	20335	50363451
Acquired amegakaryocytic thrombocytopenia	21.16	9.74	6	221332	9	50383777
Leukopenia	21.12	9.74	191	221147	67337	50316449
Restlessness	21.12	9.74	185	221153	24988	50358798
Pneumocystis jirovecii pneumonia	20.83	9.74	20	221318	14643	50369143
Self-injurious ideation	20.78	9.74	36	221302	2193	50381593
Asthenia	20.74	9.74	1642	219696	317400	50066386
Toxicologic test abnormal	20.62	9.74	19	221319	604	50383182
Rhabdomyolysis	20.54	9.74	261	221077	38766	50345020
Cellulitis	20.54	9.74	204	221134	70594	50313192
Multiple sclerosis relapse	20.40	9.74	282	221056	42682	50341104
Hepatic function abnormal	20.23	9.74	74	221264	32607	50351179
Injection site swelling	20.12	9.74	104	221234	41669	50342117
Somnambulism	20.02	9.74	57	221281	4867	50378919
Electrocardiogram QRS complex prolonged	19.94	9.74	60	221278	5284	50378502
Face injury	19.93	9.74	40	221298	2726	50381060
Neurotoxicity	19.92	9.74	21	221317	14719	50369067
Drug withdrawal convulsions	19.90	9.74	27	221311	1326	50382460
Metastases to liver	19.79	9.74	36	221302	20068	50363718
Mood altered	19.73	9.74	109	221229	12664	50371122
Logorrhoea	19.69	9.74	36	221302	2288	50381498
Alcohol use	19.63	9.74	33	221305	1962	50381824
Platelet count decreased	19.59	9.74	316	221022	100410	50283376
Wrong patient	19.56	9.74	9	221329	81	50383705
Asthma	19.53	9.74	274	221064	89063	50294723
Basal cell carcinoma	19.46	9.74	46	221292	23310	50360476
Panic reaction	19.33	9.74	46	221292	3523	50380263
Drug eruption	19.27	9.74	47	221291	23559	50360227
Parkinsonism	19.04	9.74	83	221255	8764	50375022
Abortion spontaneous	19.01	9.74	106	221232	41666	50342120
Tarsal tunnel syndrome	18.94	9.74	17	221321	522	50383264
Gun shot wound	18.92	9.74	9	221329	88	50383698
Body temperature increased	18.73	9.74	72	221266	31269	50352517
Thermal burn	18.68	9.74	55	221283	4786	50379000
Hypochloraemia	18.59	9.74	29	221309	1618	50382168
Feeling jittery	18.43	9.74	97	221241	11063	50372723
Mental status changes	18.43	9.74	241	221097	36031	50347755
Cutaneous T-cell dyscrasia	18.41	9.74	8	221330	62	50383724
Blood lactic acid	18.40	9.74	9	221329	94	50383692
Blood bilirubin increased	18.26	9.74	75	221263	31963	50351823
Inappropriate antidiuretic hormone secretion	18.23	9.74	109	221229	13034	50370752
Depressed mood	18.11	9.74	228	221110	33795	50349991
Cyanosis	18.01	9.74	121	221217	15063	50368723
Initial insomnia	17.76	9.74	56	221282	5059	50378727
Partner stress	17.67	9.74	13	221325	299	50383487
Tension	17.63	9.74	38	221300	2724	50381062
Substance dependence	17.52	9.74	11	221327	193	50383593
Major depression	17.51	9.74	68	221270	6816	50376970
Ulcer	17.46	9.74	39	221299	20161	50363625
Vision blurred	17.41	9.74	459	220879	78188	50305598
Graft versus host disease	17.38	9.74	3	221335	6163	50377623
Aplastic anaemia	17.34	9.74	6	221332	7697	50376089
Dermatitis allergic	17.33	9.74	18	221320	12702	50371084
Lupus-like syndrome	17.28	9.74	10	221328	9481	50374305
Disease progression	17.26	9.74	305	221033	95561	50288225
Chronic obstructive pulmonary disease	17.24	9.74	329	221009	53106	50330680
Incoherent	17.23	9.74	49	221289	4181	50379605
Diarrhoea	17.17	9.74	2284	219054	586192	49797594
Cardiogenic shock	17.14	9.74	122	221216	15477	50368309
Stupor	17.10	9.74	44	221294	3539	50380247
Drug screen negative	17.00	9.74	12	221326	258	50383528
Generalised tonic-clonic seizure	16.98	9.74	183	221155	26127	50357659
Torsade de pointes	16.96	9.74	99	221239	11736	50372050
Purging	16.96	9.74	7	221331	47	50383739
Productive cough	16.94	9.74	148	221190	52546	50331240
Morbid thoughts	16.92	9.74	16	221322	526	50383260
Therapeutic response decreased	16.85	9.74	129	221209	47102	50336684
Sarcomatoid carcinoma	16.69	9.74	6	221332	26	50383760
Product substitution issue	16.66	9.74	112	221226	13945	50369841
Mental disability	16.66	9.74	8	221330	80	50383706
Burn oesophageal	16.63	9.74	10	221328	162	50383624
Formication	16.61	9.74	44	221294	3602	50380184
Death of relative	16.58	9.74	11	221327	213	50383573
Neuroleptic malignant syndrome	16.54	9.74	94	221244	11036	50372750
Drug-induced liver injury	16.50	9.74	65	221273	28030	50355756
Septic shock	16.48	9.74	165	221173	57010	50326776
Body temperature decreased	16.46	9.74	29	221309	16366	50367420
Disinhibition	16.45	9.74	19	221319	791	50382995
Tubulointerstitial nephritis and uveitis syndrome	16.41	9.74	10	221328	166	50383620
Blood pressure diastolic increased	16.41	9.74	6	221332	7437	50376349
Substance use	16.34	9.74	13	221325	337	50383449
Developmental delay	16.33	9.74	24	221314	1270	50382516
Tumour lysis syndrome	16.33	9.74	6	221332	7415	50376371
Alcoholism	16.21	9.74	27	221311	1593	50382193
Dysuria	16.03	9.74	193	221145	28311	50355475
Hyperreflexia	15.94	9.74	54	221284	5064	50378722
Electrocardiogram QRS complex shortened	15.87	9.74	14	221324	420	50383366
Haemophagocytic lymphohistiocytosis	15.86	9.74	9	221329	8624	50375162
Ataxia	15.84	9.74	109	221229	13677	50370109
Anaemia	15.83	9.74	923	220415	251533	50132253
Pain in extremity	15.81	9.74	1005	220333	271860	50111926
Blood pressure systolic abnormal	15.70	9.74	7	221331	7699	50376087
Osteonecrosis of jaw	15.65	9.74	81	221257	32445	50351341
Alkalosis hypochloraemic	15.62	9.74	9	221329	134	50383652
Cardiac valve disease	15.56	9.74	44	221294	3742	50380044
Delusion	15.53	9.74	89	221249	10480	50373306
Cardio-respiratory arrest neonatal	15.52	9.74	4	221334	3	50383783
Tendonitis	15.49	9.74	31	221307	16674	50367112
Liver injury	15.47	9.74	56	221282	24750	50359036
Diffuse large B-cell lymphoma	15.43	9.74	3	221335	5659	50378127
Bundle branch block right	15.35	9.74	50	221288	4595	50379191
Skin necrosis	15.23	9.74	15	221323	10852	50372934
Slow speech	15.07	9.74	23	221315	1259	50382527
Multiple organ dysfunction syndrome	15.04	9.74	144	221194	50193	50333593
Nodular rash	15.01	9.74	10	221328	195	50383591
Unresponsive to stimuli	14.98	9.74	202	221136	30407	50353379
Gambling disorder	14.86	9.74	22	221316	1172	50382614
Obsessive-compulsive personality disorder	14.85	9.74	5	221333	17	50383769
Dysgeusia	14.82	9.74	246	221092	38670	50345116
Pneumonia streptococcal	14.76	9.74	26	221312	1605	50382181
Theft	14.75	9.74	7	221331	68	50383718
Migraine	14.61	9.74	432	220906	74848	50308938
Coma scale	14.57	9.74	6	221332	40	50383746
Apraxia	14.46	9.74	25	221313	1520	50382266
Therapeutic response unexpected	14.43	9.74	119	221219	15796	50367990
Tenosynovitis	14.34	9.74	15	221323	10550	50373236
Faecal vomiting	14.26	9.74	15	221323	562	50383224
Neonatal behavioural syndrome	14.21	9.74	6	221332	43	50383743
Waxy flexibility	14.19	9.74	8	221330	114	50383672
Brain death	14.14	9.74	35	221303	2748	50381038
Haemoglobin decreased	14.12	9.74	436	220902	126780	50257006
Vascular headache	14.09	9.74	6	221332	44	50383742
Uveitis	14.06	9.74	12	221326	9298	50374488
Panniculitis	14.06	9.74	10	221328	8493	50375293
Obsessive thoughts	13.97	9.74	14	221324	495	50383291
Acute myeloid leukaemia	13.96	9.74	28	221310	15046	50368740
Emotional disorder	13.85	9.74	94	221244	11742	50372044
Metastases to bone	13.78	9.74	37	221301	17958	50365828
Prothrombin level decreased	13.76	9.74	14	221324	504	50383282
Normal newborn	13.76	9.74	6	221332	6685	50377101
Osteoarthritis	13.75	9.74	214	221124	68392	50315394
Ascites	13.73	9.74	96	221242	35765	50348021
Localised infection	13.70	9.74	61	221277	25424	50358362
Blood parathyroid hormone decreased	13.67	9.74	7	221331	7107	50376679
Oesophageal food impaction	13.62	9.74	9	221329	173	50383613
Adverse event	13.59	9.74	124	221214	43639	50340147
Alanine aminotransferase increased	13.50	9.74	289	221049	88070	50295716
Diabetic ketoacidosis	13.50	9.74	37	221301	17835	50365951
Pleural effusion	13.46	9.74	263	221075	81191	50302595
Injection site pain	13.45	9.74	376	220962	110648	50273138
Wrong rate	13.44	9.74	6	221332	50	50383736
Pre-existing condition improved	13.35	9.74	64	221274	7033	50376753
LDL/HDL ratio increased	13.31	9.74	3	221335	0	50383786
Maternal exposure before pregnancy	13.24	9.74	4	221334	5593	50378193
Tardive dyskinesia	13.23	9.74	65	221273	7214	50376572
Oropharyngeal pain	13.22	9.74	250	221088	77551	50306235
Soliloquy	13.19	9.74	9	221329	183	50383603
Full blood count abnormal	13.17	9.74	55	221283	23333	50360453
Dizziness	13.13	9.74	1718	219620	344651	50039135
Joint effusion	13.10	9.74	23	221315	12998	50370788
Cerebral microangiopathy	13.09	9.74	10	221328	244	50383542
Exposure via inhalation	13.02	9.74	5	221333	27	50383759
Gallbladder disorder	13.00	9.74	121	221217	16621	50367165
Product physical issue	12.87	9.74	45	221293	4287	50379499
Atrioventricular septal defect	12.84	9.74	10	221328	251	50383535
Brugada syndrome	12.78	9.74	11	221327	319	50383467
Laryngomalacia	12.76	9.74	6	221332	57	50383729
Premature labour	12.74	9.74	19	221319	11457	50372329
Homicidal ideation	12.73	9.74	25	221313	1677	50382109
Phobia	12.73	9.74	11	221327	321	50383465
Suspiciousness	12.73	9.74	11	221327	321	50383465
Distributive shock	12.72	9.74	17	221321	823	50382963
Congenital central nervous system anomaly	12.70	9.74	11	221327	322	50383464
Conversion disorder	12.62	9.74	24	221314	1572	50382214
Oesophageal achalasia	12.53	9.74	12	221326	401	50383385
Hyporesponsive to stimuli	12.52	9.74	18	221320	934	50382852
Gastrointestinal haemorrhage	12.34	9.74	236	221102	73085	50310701
Pneumoconiosis	12.25	9.74	4	221334	12	50383774
Cutaneous lymphoma	12.24	9.74	8	221330	151	50383635
Libido decreased	12.20	9.74	30	221308	2346	50381440
Cardio-respiratory distress	12.19	9.74	8	221330	152	50383634
Persecutory delusion	12.11	9.74	30	221308	2357	50381429
Performance status decreased	12.04	9.74	36	221302	3159	50380627
Divorced	12.02	9.74	4	221334	13	50383773
Victim of crime	12.00	9.74	6	221332	66	50383720
Deep vein thrombosis	11.96	9.74	412	220926	72892	50310894
Gallbladder hypofunction	11.83	9.74	13	221325	512	50383274
Sleep disorder due to a general medical condition	11.76	9.74	9	221329	7362	50376424
Cognitive disorder	11.72	9.74	264	221074	43859	50339927
Craniosynostosis	11.71	9.74	8	221330	163	50383623
Bone density decreased	11.66	9.74	19	221319	11056	50372730
Coagulation factor V level decreased	11.62	9.74	10	221328	290	50383496
Musculoskeletal disorder	11.60	9.74	38	221300	17311	50366475
Poor venous access	11.59	9.74	17	221321	10323	50373463
Prescription drug used without a prescription	11.56	9.74	24	221314	1676	50382110
Throat irritation	11.55	9.74	81	221257	30158	50353628
Drug screen false positive	11.53	9.74	16	221322	803	50382983
Prothrombin level increased	11.46	9.74	9	221329	229	50383557
Hyperaldosteronism	11.46	9.74	9	221329	229	50383557
Toxic epidermal necrolysis	11.43	9.74	50	221288	20942	50362844
Paranoia	11.41	9.74	81	221257	10267	50373519
Crime	11.38	9.74	4	221334	16	50383770
Hepatotoxicity	11.37	9.74	71	221267	27155	50356631
Product quality issue	11.36	9.74	194	221144	30664	50353122
Hypercalcaemia	11.32	9.74	58	221280	23294	50360492
Eating disorder	11.29	9.74	110	221228	15299	50368487
Pharyngitis	11.26	9.74	39	221299	17464	50366322
Limb fracture	11.24	9.74	3	221335	3	50383783
Pelvic floor dysfunction	11.24	9.74	3	221335	3	50383783
Enthesopathy	11.20	9.74	9	221329	7184	50376602
Blastocystis infection	11.19	9.74	4	221334	17	50383769
Tubulointerstitial nephritis	11.11	9.74	32	221306	15179	50368607
Injection site reaction	11.09	9.74	153	221185	49879	50333907
Balance disorder	11.08	9.74	395	220943	70195	50313591
Creatinine renal clearance decreased	11.06	9.74	22	221316	11859	50371927
Counterfeit product administered	11.01	9.74	4	221334	18	50383768
Hypotonia	10.99	9.74	67	221271	8067	50375719
Hair texture abnormal	10.88	9.74	38	221300	3618	50380168
Clostridium difficile infection	10.80	9.74	66	221272	25373	50358413
Liver function test abnormal	10.78	9.74	133	221205	44206	50339580
Retrograde amnesia	10.72	9.74	11	221327	400	50383386
Depersonalisation/derealisation disorder	10.72	9.74	19	221319	1179	50382607
Joint stiffness	10.71	9.74	83	221255	30225	50353561
Corneal reflex decreased	10.67	9.74	7	221331	133	50383653
Perseveration	10.67	9.74	9	221329	254	50383532
Akathisia	10.63	9.74	67	221271	8162	50375624
Haemorrhage	10.60	9.74	167	221171	53274	50330512
Dyskinesia	10.57	9.74	176	221162	27685	50356101
Blood alcohol increased	10.57	9.74	13	221325	579	50383207
Oligohydramnios	10.55	9.74	6	221332	5744	50378042
Blood creatine phosphokinase increased	10.54	9.74	168	221170	26199	50357587
Blood cholesterol increased	10.47	9.74	174	221164	55041	50328745
Pancreatitis acute	10.39	9.74	154	221184	23658	50360128
Beta haemolytic streptococcal infection	10.36	9.74	24	221314	1806	50381980
Encephalopathy	10.34	9.74	206	221132	33505	50350281
Haematochezia	10.32	9.74	118	221220	39764	50344022
Rhinorrhoea	10.30	9.74	161	221177	51422	50332364
Abdominal operation	10.29	9.74	12	221326	505	50383281
Injection site pruritus	10.29	9.74	120	221218	40291	50343495
Reduced facial expression	10.25	9.74	22	221316	1572	50382214
Nephropathy toxic	10.23	9.74	12	221326	8017	50375769
Injection site bruising	10.23	9.74	107	221231	36661	50347125
Newborn persistent pulmonary hypertension	10.23	9.74	7	221331	143	50383643
Venoocclusive liver disease	10.16	9.74	3	221335	4258	50379528
Arthritis bacterial	10.15	9.74	6	221332	5623	50378163
Postmortem blood drug level abnormal	10.11	9.74	10	221328	348	50383438
Electroencephalogram abnormal	10.10	9.74	36	221302	3463	50380323
Erythrodermic psoriasis	10.10	9.74	16	221322	905	50382881
Purpura senile	10.07	9.74	12	221326	517	50383269
Hyperinsulinism	10.04	9.74	3	221335	6	50383780
Cardioplegia	10.04	9.74	3	221335	6	50383780
Pneumonia aspiration	10.03	9.74	191	221147	30813	50352973
Nephrosclerosis	10.01	9.74	16	221322	912	50382874
Sensitivity to weather change	10.00	9.74	7	221331	5994	50377792
Tuberculosis	9.97	9.74	18	221320	10065	50373721
Lethargy	9.95	9.74	285	221053	49147	50334639
Polyarthritis	9.94	9.74	12	221326	7915	50375871
Gait disturbance	9.88	9.74	773	220565	149232	50234554
Feeling of relaxation	9.84	9.74	5	221333	57	50383729
Polydipsia	9.76	9.74	33	221305	3091	50380695
Attention deficit hyperactivity disorder	9.76	9.74	28	221310	2401	50381385

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug abuse	7256.17	10.54	4129	101626	75754	29393018
Completed suicide	2069.61	10.54	2046	103709	88200	29380572
Toxicity to various agents	2015.05	10.54	2770	102985	170891	29297881
Respiratory arrest	1809.71	10.54	1135	104620	24698	29444074
Poisoning	1432.25	10.54	704	105051	9289	29459483
Cardio-respiratory arrest	1048.63	10.54	1088	104667	49513	29419259
Cardiac arrest	870.68	10.54	1286	104469	84305	29384467
Intentional product misuse	736.85	10.54	756	104999	33905	29434867
Drug dependence	674.26	10.54	576	105179	20405	29448367
Sopor	655.28	10.54	436	105319	10498	29458274
Overdose	526.58	10.54	988	104767	78831	29389941
Coma	522.54	10.54	674	105081	38776	29429996
Suicide attempt	509.59	10.54	619	105136	33491	29435281
Intentional overdose	440.91	10.54	613	105142	37915	29430857
Poisoning deliberate	349.26	10.54	231	105524	5500	29463272
Exposure via ingestion	270.64	10.54	136	105619	1882	29466890
Prescription form tampering	229.90	10.54	79	105676	373	29468399
Withdrawal syndrome	224.72	10.54	235	105520	10757	29458015
Drug withdrawal syndrome	208.33	10.54	288	105467	17696	29451076
Drug use disorder	189.51	10.54	130	105625	3292	29465480
Somnolence	186.66	10.54	747	105008	93208	29375564
Accidental overdose	186.43	10.54	270	105485	17323	29451449
Substance abuse	177.54	10.54	166	105589	6621	29462151
Intentional self-injury	176.00	10.54	220	105535	12241	29456531
Off label use	158.04	10.54	550	105205	300250	29168522
Miosis	147.44	10.54	162	105593	7847	29460925
Drug abuser	145.66	10.54	116	105639	3711	29465061
Anxiety	138.85	10.54	639	105116	84726	29384046
Death	136.68	10.54	1841	103914	340243	29128529
Febrile neutropenia	127.43	10.54	128	105627	112112	29356660
Respiratory depression	125.37	10.54	195	105560	13328	29455444
Bradypnoea	124.08	10.54	87	105668	2284	29466488
Pyrexia	122.48	10.54	571	105184	287051	29181721
Suicidal ideation	116.98	10.54	330	105425	34386	29434386
Agitation	101.01	10.54	407	105348	50897	29417875
Drug screen positive	99.47	10.54	93	105662	3708	29465064
Depression	97.96	10.54	579	105176	84568	29384204
Drug ineffective	96.80	10.54	833	104922	362337	29106435
Pneumonia	84.50	10.54	736	105019	319436	29149336
Bradyphrenia	82.39	10.54	88	105667	4126	29464646
Insomnia	80.84	10.54	569	105186	88192	29380580
Depressed level of consciousness	72.63	10.54	293	105462	36649	29432123
Sepsis	71.90	10.54	265	105490	142417	29326355
Accidental death	71.77	10.54	60	105695	2058	29466714
Neutropenia	69.43	10.54	240	105515	131471	29337301
Counterfeit product administered	67.96	10.54	25	105730	149	29468623
Product use in unapproved indication	64.98	10.54	133	105622	86742	29382030
Treatment failure	63.88	10.54	26	105729	36913	29431859
Panic attack	63.56	10.54	110	105645	8216	29460556
Renal impairment	62.99	10.54	122	105633	81211	29387561
Unresponsive to stimuli	61.64	10.54	214	105541	24912	29443860
Cough	60.83	10.54	240	105515	126487	29342285
Infection	59.54	10.54	115	105640	76636	29392136
Asphyxia	58.38	10.54	83	105672	5232	29463540
C-reactive protein increased	56.74	10.54	45	105710	44218	29424554
Aggression	56.18	10.54	264	105491	35277	29433495
Drug resistance	55.73	10.54	6	105749	21534	29447238
Drug tolerance	55.04	10.54	52	105703	2101	29466671
Cytomegalovirus infection	54.04	10.54	9	105746	23206	29445566
Irritability	53.76	10.54	188	105567	21964	29446808
Infusion related reaction	53.32	10.54	47	105708	43839	29424933
Amnesia	52.24	10.54	189	105566	22454	29446318
Toxicologic test abnormal	51.86	10.54	29	105726	504	29468268
Pulmonary oedema	51.29	10.54	294	105461	42441	29426331
Product counterfeit	50.46	10.54	19	105736	122	29468650
Lower respiratory tract infection	50.34	10.54	16	105739	26486	29442286
Platelet count decreased	49.72	10.54	199	105556	104473	29364299
Anaemia	49.34	10.54	470	105285	200481	29268291
Postmortem blood drug level abnormal	48.95	10.54	23	105732	272	29468500
Diarrhoea	48.86	10.54	867	104888	331831	29136941
Alcohol interaction	46.87	10.54	53	105702	2650	29466122
Abnormal behaviour	45.10	10.54	183	105572	22944	29445828
Rash	44.47	10.54	449	105306	189370	29279402
Hepatic function abnormal	44.23	10.54	45	105710	39214	29429558
Self-medication	43.92	10.54	46	105709	2108	29466664
Narcotic bowel syndrome	39.82	10.54	16	105739	125	29468647
Acute kidney injury	39.29	10.54	690	105065	264577	29204195
Tremor	39.27	10.54	419	105336	73119	29395653
Mucosal inflammation	38.18	10.54	34	105721	31561	29437211
Disorientation	37.36	10.54	206	105549	29309	29439463
Abulia	37.08	10.54	23	105732	488	29468284
Pulmonary congestion	36.87	10.54	113	105642	12323	29456449
Cardiac failure	36.85	10.54	152	105603	79135	29389637
Pancytopenia	36.47	10.54	163	105592	83005	29385767
Blood creatinine increased	36.00	10.54	169	105586	84933	29383839
Neutrophil count decreased	34.89	10.54	64	105691	43503	29425269
Interstitial lung disease	34.72	10.54	99	105656	57619	29411153
Loss of consciousness	34.58	10.54	411	105344	73645	29395127
COVID-19	34.44	10.54	47	105708	35967	29432805
Anger	34.22	10.54	101	105654	10789	29457983
Dyspnoea	34.10	10.54	899	104856	325833	29142939
Respiratory rate decreased	33.49	10.54	38	105717	1907	29466865
Condition aggravated	33.02	10.54	349	105406	145946	29322826
Joint swelling	32.98	10.54	81	105674	49549	29419223
Paramnesia	32.64	10.54	8	105747	6	29468766
Brain oedema	32.54	10.54	107	105648	12113	29456659
White blood cell count decreased	32.14	10.54	171	105584	83191	29385581
Arthralgia	31.94	10.54	332	105423	139285	29329487
Road traffic accident	31.83	10.54	125	105630	15436	29453336
Haemoglobin decreased	31.22	10.54	243	105512	108132	29360640
Nervousness	31.01	10.54	100	105655	11206	29457566
Altered state of consciousness	30.88	10.54	147	105608	19742	29449030
Suspected suicide	30.54	10.54	53	105702	3967	29464805
Feeling abnormal	30.37	10.54	313	105442	54132	29414640
Dependence	30.36	10.54	27	105728	1008	29467764
Pneumocystis jirovecii pneumonia	30.35	10.54	11	105744	16768	29452004
Bone marrow failure	30.31	10.54	32	105723	27417	29441355
Respiratory failure	30.26	10.54	213	105542	96918	29371854
Alcohol abuse	30.18	10.54	55	105700	4278	29464494
Myelosuppression	30.16	10.54	4	105751	12223	29456549
Drug withdrawal syndrome neonatal	30.13	10.54	48	105707	3347	29465425
Disturbance in attention	29.47	10.54	153	105602	21271	29447501
Analgesic drug level increased	29.30	10.54	21	105734	571	29468201
Drug detoxification	29.18	10.54	14	105741	174	29468598
Gastrointestinal haemorrhage	29.09	10.54	166	105589	79367	29389405
Drug intolerance	29.08	10.54	83	105672	48296	29420476
Disease progression	28.89	10.54	173	105582	81743	29387029
Homicide	28.81	10.54	25	105730	903	29467869
Alcohol use	28.79	10.54	45	105710	3087	29465685
Therapeutic product effect incomplete	28.66	10.54	61	105694	39244	29429528
Bladder dilatation	28.59	10.54	29	105726	1279	29467493
Neutropenic sepsis	28.54	10.54	4	105751	11723	29457049
General physical health deterioration	28.52	10.54	233	105522	102624	29366148
Renal failure	27.95	10.54	280	105475	118319	29350453
Rheumatoid arthritis	27.78	10.54	45	105710	32107	29436665
Psychomotor hyperactivity	27.57	10.54	78	105677	8135	29460637
Angioedema	27.27	10.54	45	105710	31870	29436902
Cerebral haemorrhage	27.14	10.54	44	105711	31382	29437390
Bradykinesia	26.91	10.54	46	105709	3401	29465371
Hyperthermia	26.40	10.54	84	105671	9346	29459426
Distributive shock	25.58	10.54	24	105731	961	29467811
Lactic acidosis	25.52	10.54	43	105712	30204	29438568
Erythema	25.45	10.54	162	105593	75444	29393328
Panic disorder	25.32	10.54	26	105729	1164	29467608
Thinking abnormal	25.19	10.54	57	105698	5179	29463593
Hospitalisation	24.73	10.54	83	105672	45905	29422867
Blood pressure fluctuation	24.53	10.54	21	105734	19873	29448899
Malignant neoplasm progression	24.48	10.54	159	105596	73700	29395072
Contraindicated product administered	24.13	10.54	18	105737	18248	29450524
Withdrawal catatonia	24.06	10.54	10	105745	86	29468686
Alanine aminotransferase increased	23.88	10.54	152	105603	70792	29397980
Exposure during pregnancy	23.77	10.54	76	105679	8478	29460294
Gun shot wound	23.62	10.54	24	105731	1061	29467711
Hypervigilance	23.56	10.54	11	105744	128	29468644
Hypervolaemia	23.55	10.54	17	105738	17528	29451244
Stomatitis	23.55	10.54	62	105693	37051	29431721
Incorrect route of product administration	23.10	10.54	88	105667	10713	29458059
Generalised anxiety disorder	22.97	10.54	19	105736	642	29468130
Dysarthria	22.95	10.54	189	105566	30722	29438050
Inadequate analgesia	22.84	10.54	37	105718	2617	29466155
Pneumonia aspiration	22.81	10.54	216	105539	36521	29432251
Nasopharyngitis	22.65	10.54	123	105632	59542	29409230
Mydriasis	22.63	10.54	60	105695	6025	29462747
Cardiac failure congestive	22.37	10.54	171	105584	76410	29392362
Deafness neurosensory	22.27	10.54	36	105719	2542	29466230
Atrial fibrillation	22.23	10.54	256	105499	105390	29363382
Accident	22.21	10.54	44	105711	3644	29465128
Drug tolerance increased	21.95	10.54	16	105739	447	29468325
Chorea	21.90	10.54	22	105733	959	29467813
Acute myocardial infarction	21.79	10.54	94	105661	48344	29420428
Hyperleukocytosis	21.71	10.54	28	105727	1607	29467165
Substance use disorder	21.42	10.54	13	105742	265	29468507
Sedation	21.04	10.54	120	105635	17285	29451487
Poverty of speech	20.89	10.54	12	105743	220	29468552
Stevens-Johnson syndrome	20.85	10.54	17	105738	16480	29452292
Bronchopulmonary aspergillosis	20.84	10.54	9	105746	12335	29456437
Aspergillus infection	20.79	10.54	6	105749	10575	29458197
Vestibular ischaemia	20.65	10.54	6	105749	14	29468758
Ascites	20.44	10.54	65	105690	36554	29432218
Oedematous pancreatitis	20.13	10.54	15	105740	434	29468338
Anaphylactic reaction	19.93	10.54	43	105712	27530	29441242
Major depression	19.86	10.54	43	105712	3792	29464980
Hypersensitivity	19.56	10.54	110	105645	52793	29415979
Drug diversion	19.54	10.54	19	105736	796	29467976
Puncture site haematoma	19.42	10.54	10	105745	146	29468626
Pleural effusion	19.42	10.54	164	105591	71744	29397028
Hyperkalaemia	19.42	10.54	134	105621	61258	29407514
Serotonin syndrome	19.40	10.54	118	105637	17394	29451378
Pathogen resistance	19.22	10.54	3	105752	8113	29460659
Pruritus	19.18	10.54	298	105457	116551	29352221
Dizziness	19.17	10.54	524	105231	189160	29279612
Haematochezia	19.04	10.54	68	105687	36915	29431857
Urticaria	18.96	10.54	116	105639	54544	29414228
Myocardial infarction	18.89	10.54	279	105476	110017	29358755
Myotonia	18.85	10.54	7	105748	43	29468729
Psoriatic arthropathy	18.74	10.54	15	105740	14676	29454096
Heart rate decreased	18.72	10.54	38	105717	24874	29443898
Catatonia	18.63	10.54	46	105709	4422	29464350
Cytokine release syndrome	18.56	10.54	12	105743	13107	29455665
Papillary muscle disorder	18.55	10.54	4	105751	0	29468772
Neurotoxicity	18.54	10.54	15	105740	14598	29454174
Leukopenia	18.20	10.54	119	105636	55084	29413688
Substance abuser	18.20	10.54	8	105747	80	29468692
Sudden death	18.20	10.54	99	105656	14011	29454761
Haemorrhage	18.18	10.54	91	105664	44981	29423791
Legal problem	18.08	10.54	10	105745	170	29468602
Confusional state	17.97	10.54	591	105164	127286	29341486
Liver disorder	17.88	10.54	46	105709	27703	29441069
Cerebral congestion	17.87	10.54	6	105749	26	29468746
Liver function test abnormal	17.83	10.54	49	105706	28869	29439903
Inappropriate schedule of product administration	17.82	10.54	90	105665	44382	29424390
Herpes zoster	17.73	10.54	52	105703	30000	29438772
Slow speech	17.68	10.54	19	105736	897	29467875
Pneumonitis	17.68	10.54	47	105708	27997	29440775
Hepatotoxicity	17.40	10.54	23	105732	17844	29450928
Tachyphylaxis	17.38	10.54	8	105747	90	29468682
Thrombocytopenia	17.33	10.54	359	105396	134464	29334308
Memory impairment	17.27	10.54	203	105552	36267	29432505
Drug withdrawal convulsions	17.20	10.54	21	105734	1140	29467632
Obstructive airways disorder	17.11	10.54	9	105746	11007	29457765
Leukoencephalopathy	17.01	10.54	40	105715	3727	29465045
Gastric haemorrhage	16.98	10.54	6	105749	9291	29459481
Blood triglycerides decreased	16.66	10.54	7	105748	62	29468710
Lymphadenopathy	16.54	10.54	41	105714	25008	29443764
Bacterial prostatitis	16.47	10.54	7	105748	64	29468708
Diabetic ketoacidosis	16.37	10.54	20	105735	16053	29452719
Foetal exposure during pregnancy	16.30	10.54	64	105691	33803	29434969
Product substitution	16.28	10.54	6	105749	36	29468736
Asthma	16.27	10.54	64	105691	33785	29434987
Anamnestic reaction	16.14	10.54	6	105749	37	29468735
Cataract	16.09	10.54	35	105720	22343	29446429
Oedema peripheral	16.03	10.54	267	105488	103290	29365482
Blood creatine phosphokinase	16.01	10.54	7	105748	69	29468703
Delirium	15.96	10.54	213	105542	39184	29429588
Bacteraemia	15.91	10.54	21	105734	16302	29452470
Cerebral infarction	15.82	10.54	41	105714	24634	29444138
Epistaxis	15.79	10.54	114	105641	51590	29417182
Ventricular tachyarrhythmia	15.74	10.54	11	105744	287	29468485
Victim of crime	15.70	10.54	12	105743	361	29468411
Brachial plexus injury	15.59	10.54	7	105748	74	29468698
Sexual dysfunction	15.56	10.54	51	105704	5763	29463009
Renal tubular necrosis	15.46	10.54	17	105738	14298	29454474
Acute myeloid leukaemia	15.33	10.54	22	105733	16491	29452281
Wheezing	15.26	10.54	64	105691	33176	29435596
Peripheral swelling	15.20	10.54	150	105605	63589	29405183
Transplant rejection	15.10	10.54	7	105748	9205	29459567
Blood pressure systolic increased	15.10	10.54	23	105732	16822	29451950
Homicidal ideation	15.06	10.54	30	105725	2494	29466278
Nephropathy toxic	15.00	10.54	10	105745	10746	29458026
Speech disorder	14.96	10.54	139	105616	23377	29445395
Tubulointerstitial nephritis	14.95	10.54	25	105730	17618	29451154
Melaena	14.95	10.54	59	105696	31117	29437655
Cyclothymic disorder	14.88	10.54	7	105748	83	29468689
Drug eruption	14.87	10.54	23	105732	16718	29452054
Intrusive thoughts	14.86	10.54	10	105745	245	29468527
Cardio-respiratory distress	14.73	10.54	8	105747	131	29468641
Hallucination, visual	14.67	10.54	98	105657	14917	29453855
Anticholinergic syndrome	14.61	10.54	17	105738	877	29467895
Thymus disorder	14.53	10.54	4	105751	7	29468765
COVID-19 pneumonia	14.47	10.54	8	105747	9514	29459258
Acute hepatic failure	14.27	10.54	13	105742	11939	29456833
Amimia	14.18	10.54	4	105751	8	29468764
Mania	14.16	10.54	65	105690	8598	29460174
Prothrombin time shortened	14.14	10.54	21	105734	1377	29467395
Liver function test increased	14.10	10.54	13	105742	11872	29456900
Dissociative disorder	13.99	10.54	9	105746	204	29468568
Psychomotor skills impaired	13.97	10.54	30	105725	2631	29466141
Sepsis pasteurella	13.91	10.54	3	105752	0	29468772
Blood lactate dehydrogenase increased	13.84	10.54	30	105725	19179	29449593
Prostate cancer	13.77	10.54	46	105709	25481	29443291
Hyporesponsive to stimuli	13.76	10.54	17	105738	934	29467838
Myositis	13.75	10.54	10	105745	10273	29458499
Osteoporosis	13.73	10.54	11	105744	10758	29458014
Drug screen negative	13.72	10.54	8	105747	151	29468621
Exposure via inhalation	13.71	10.54	5	105750	29	29468743
Arthropathy	13.68	10.54	36	105719	21518	29447254
Panic reaction	13.66	10.54	20	105735	1295	29467477
Inflammation	13.65	10.54	39	105716	22689	29446083
Scleroderma renal crisis	13.55	10.54	7	105748	103	29468669
Cholangitis	13.53	10.54	5	105750	7532	29461240
Physical assault	13.52	10.54	18	105737	1066	29467706
Oedema	13.48	10.54	87	105668	40396	29428376
Osteonecrosis of jaw	13.44	10.54	24	105731	16486	29452286
Tumour lysis syndrome	13.39	10.54	18	105737	13866	29454906
Femoral artery aneurysm	13.23	10.54	8	105747	162	29468610
Hyperhidrosis	13.19	10.54	313	105442	64227	29404545
Impatience	13.13	10.54	10	105745	299	29468473
Therapeutic response decreased	13.01	10.54	45	105710	24666	29444106
Squamous cell carcinoma of skin	12.98	10.54	9	105746	9477	29459295
Full blood count abnormal	12.98	10.54	21	105734	14992	29453780
Adrenergic syndrome	12.92	10.54	6	105749	69	29468703
Incision site pain	12.89	10.54	23	105732	1760	29467012
Central nervous system necrosis	12.86	10.54	7	105748	115	29468657
Second primary malignancy	12.82	10.54	4	105751	6701	29462071
Bipolar disorder	12.77	10.54	33	105722	3262	29465510
Hypocalcaemia	12.75	10.54	35	105720	20630	29448142
Judgement impaired	12.71	10.54	13	105742	579	29468193
Feeling jittery	12.68	10.54	35	105720	3598	29465174
Haemoconcentration	12.68	10.54	5	105750	37	29468735
Euphoric mood	12.62	10.54	42	105713	4783	29463989
Victim of homicide	12.60	10.54	7	105748	120	29468652
Peripheral nerve paresis	12.56	10.54	5	105750	38	29468734
Troponin T increased	12.53	10.54	20	105735	1397	29467375
Low birth weight baby	12.53	10.54	4	105751	6604	29462168
Theft	12.49	10.54	9	105746	247	29468525
Aspartate aminotransferase increased	12.44	10.54	145	105610	59580	29409192
Prescription drug used without a prescription	12.36	10.54	19	105736	1285	29467487
Medication error	12.32	10.54	123	105632	21088	29447684
Progressive multifocal leukoencephalopathy	12.30	10.54	8	105747	8711	29460061
Paradoxical drug reaction	12.26	10.54	29	105726	2712	29466060
Septic shock	12.23	10.54	154	105601	62406	29406366
Mobility decreased	12.23	10.54	49	105706	25731	29443041
Chloasma	12.17	10.54	4	105751	16	29468756
Cellulitis	12.17	10.54	105	105650	45735	29423037
Upper gastrointestinal haemorrhage	12.16	10.54	39	105716	21875	29446897
Therapy non-responder	12.13	10.54	63	105692	30848	29437924
Blood alcohol increased	12.13	10.54	14	105741	716	29468056
Hallucination	12.12	10.54	226	105529	44486	29424286
Amnestic disorder	12.11	10.54	8	105747	190	29468582
Electrocardiogram QT prolonged	12.10	10.54	189	105566	35948	29432824
Conversion disorder	12.06	10.54	10	105745	339	29468433
Lip swelling	12.06	10.54	16	105739	12394	29456378
Pulseless electrical activity	12.01	10.54	4	105751	6430	29462342
Nervous system disorder	11.95	10.54	82	105673	12592	29456180
Clostridium difficile colitis	11.88	10.54	18	105737	13194	29455578
Oropharyngeal pain	11.88	10.54	59	105696	29226	29439546
Product use issue	11.87	10.54	122	105633	51322	29417450
Benign mesenteric neoplasm	11.84	10.54	3	105752	3	29468769
Shoplifting	11.84	10.54	3	105752	3	29468769
Personality change	11.80	10.54	40	105715	4598	29464174
Colitis microscopic	11.80	10.54	22	105733	1741	29467031
Conjunctivitis	11.75	10.54	7	105748	7991	29460781
Substance-induced mood disorder	11.75	10.54	6	105749	86	29468686
Basal cell carcinoma	11.70	10.54	27	105728	16883	29451889
Acute stress disorder	11.65	10.54	7	105748	140	29468632
Hypoventilation	11.58	10.54	29	105726	2812	29465960
Hepatic enzyme increased	11.58	10.54	72	105683	33727	29435045
Sluggishness	11.51	10.54	30	105725	2981	29465791
Hypothermia	11.36	10.54	64	105691	9175	29459597
Haematuria	11.32	10.54	102	105653	44037	29424735
Circulatory collapse	11.24	10.54	32	105723	18641	29450131
Sleep disorder	11.22	10.54	135	105620	24251	29444521
Body temperature decreased	11.15	10.54	13	105742	10651	29458121
Cardiorenal syndrome	11.13	10.54	13	105742	673	29468099
Urinary tract infection	11.04	10.54	187	105568	72167	29396605
Erythema multiforme	11.00	10.54	7	105748	7710	29461062
Extrapyramidal disorder	10.77	10.54	71	105684	10760	29458012
Sputum discoloured	10.74	10.54	5	105750	6558	29462214
Respiratory acidosis	10.73	10.54	37	105718	4291	29464481
Malaise	10.72	10.54	464	105291	159138	29309634
Osteonecrosis	10.70	10.54	20	105735	13499	29455273
Pulmonary fibrosis	10.69	10.54	25	105730	15557	29453215
Ear infection	10.67	10.54	8	105747	8092	29460680
Injection site pain	10.66	10.54	70	105685	32376	29436396
Visceral congestion	10.63	10.54	11	105744	497	29468275
Apathy	10.61	10.54	47	105708	6124	29462648
Atrial flutter	10.60	10.54	21	105734	13873	29454899
Paranoia	10.59	10.54	66	105689	9811	29458961

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug abuse	11923.73	9.89	7147	256474	125227	64109884
Completed suicide	6041.10	9.89	5897	257724	218517	64016594
Toxicity to various agents	3562.92	9.89	5758	257863	357755	63877356
Respiratory arrest	3342.65	9.89	2293	261328	50692	64184419
Poisoning	2442.39	9.89	1363	262258	20516	64214595
Sopor	2441.08	9.89	1517	262104	28144	64206967
Cardio-respiratory arrest	1998.33	9.89	2230	261391	96163	64138948
Cardiac arrest	1811.65	9.89	2661	260960	151403	64083708
Suicide attempt	1324.96	9.89	1541	262080	69466	64165645
Intentional overdose	1236.04	9.89	1675	261946	88269	64146842
Intentional product misuse	1111.72	9.89	1423	262198	70872	64164239
Coma	1096.58	9.89	1560	262061	86055	64149056
Overdose	1088.02	9.89	2164	261457	157402	64077709
Drug dependence	1060.30	9.89	964	262657	32348	64202763
Poisoning deliberate	939.85	9.89	621	263000	12837	64222274
Intentional self-injury	593.25	9.89	661	262960	28383	64206728
Somnolence	551.70	9.89	1958	261663	201687	64033424
Death	503.61	9.89	3534	260087	479171	63755940
Exposure via ingestion	431.71	9.89	262	263359	4640	64230471
Drug ineffective	399.89	9.89	1924	261697	838323	63396788
Off label use	366.88	9.89	1342	262279	631464	63603647
Drug withdrawal syndrome	353.12	9.89	531	263090	30760	64204351
Synovitis	337.59	9.89	16	263605	99074	64136037
Substance abuse	331.54	9.89	287	263334	9005	64226106
Drug use disorder	298.72	9.89	226	263395	5828	64229283
Bradyphrenia	296.78	9.89	271	263350	9135	64225976
Withdrawal syndrome	294.55	9.89	419	263202	23073	64212038
Infusion related reaction	288.85	9.89	156	263465	164311	64070800
Drug abuser	286.99	9.89	217	263404	5591	64229520
Treatment failure	285.17	9.89	64	263557	116752	64118359
Drug intolerance	273.80	9.89	220	263401	187772	64047339
Anxiety	265.89	9.89	1574	262047	201075	64034036
Contraindicated product administered	263.36	9.89	59	263562	107770	64127341
Joint swelling	256.93	9.89	301	263320	215081	64020030
Lower respiratory tract infection	236.70	9.89	49	263572	94565	64140546
Suicidal ideation	235.03	9.89	701	262920	65841	64169270
Pemphigus	227.70	9.89	4	263617	60697	64174414
Accidental overdose	224.39	9.89	452	263169	33105	64202006
Depression	216.02	9.89	1385	262236	181906	64053205
Rheumatoid arthritis	212.04	9.89	215	263406	164079	64071032
Hand deformity	207.92	9.89	12	263609	62759	64172352
Mydriasis	197.71	9.89	277	263344	15035	64220076
Pyrexia	193.64	9.89	1413	262208	557231	63677880
Miosis	192.54	9.89	254	263367	13012	64222099
Agitation	192.19	9.89	793	262828	87574	64147537
Febrile neutropenia	186.74	9.89	299	263322	187358	64047753
Anti-cyclic citrullinated peptide antibody positive	182.95	9.89	4	263617	49558	64185553
Arthropathy	174.26	9.89	143	263478	120824	64114287
Pericarditis	165.71	9.89	28	263593	62488	64172623
Nasopharyngitis	163.50	9.89	348	263273	195725	64039386
Infection	161.91	9.89	319	263302	184561	64050550
Systemic lupus erythematosus	160.80	9.89	58	263563	77554	64157557
Prescription form tampering	158.07	9.89	59	263562	315	64234796
Respiratory depression	149.89	9.89	310	263311	23133	64211978
Maternal exposure during pregnancy	146.15	9.89	107	263514	95777	64139334
Bradypnoea	144.25	9.89	139	263482	5020	64230091
Pneumonia	143.93	9.89	1528	262093	558048	63677063
Arthralgia	140.64	9.89	1145	262476	441115	63793996
Panic attack	138.60	9.89	281	263340	20672	64214439
Drug screen positive	132.01	9.89	139	263482	5590	64229521
Depressed level of consciousness	128.31	9.89	665	262956	80771	64154340
Loss of consciousness	127.77	9.89	1040	262581	147325	64087786
Rash	126.95	9.89	1230	262391	457319	63777792
Hypersensitivity	125.22	9.89	399	263222	196053	64039058
Therapeutic product effect decreased	124.19	9.89	174	263447	115177	64119934
Duodenal ulcer perforation	123.29	9.89	4	263617	34621	64200490
Hepatic enzyme increased	121.87	9.89	215	263406	129728	64105383
C-reactive protein increased	121.49	9.89	125	263496	94784	64140327
Tremor	116.48	9.89	1018	262603	147212	64087899
Glossodynia	115.51	9.89	60	263561	64636	64170475
Sepsis	114.92	9.89	517	263104	229824	64005287
Victim of chemical submission	114.76	9.89	44	263577	256	64234855
Cough	112.37	9.89	748	262873	301400	63933711
General physical health deterioration	109.22	9.89	447	263174	203978	64031133
Insomnia	107.88	9.89	1260	262361	196576	64038535
Swelling	107.36	9.89	318	263303	159900	64075211
Product use in unapproved indication	106.84	9.89	367	263254	176251	64058860
Peripheral swelling	102.79	9.89	472	263149	208681	64026430
Helicobacter infection	102.06	9.89	17	263604	38345	64196766
Bradykinesia	102.06	9.89	130	263491	6430	64228681
Drug resistance	101.73	9.89	12	263609	35090	64200021
Renal impairment	99.38	9.89	256	263365	134761	64100350
Neutropenia	99.02	9.89	574	263047	239050	63996061
Altered state of consciousness	97.72	9.89	359	263262	37543	64197568
Disturbance in attention	97.58	9.89	379	263242	40695	64194416
Alcohol abuse	96.59	9.89	109	263512	4743	64230368
Cytomegalovirus infection	93.56	9.89	19	263602	37180	64197931
Therapeutic product effect incomplete	92.76	9.89	176	263445	103306	64131805
Accidental death	92.35	9.89	94	263527	3631	64231480
Product use issue	91.25	9.89	316	263305	151399	64083712
Wound	87.78	9.89	110	263511	76367	64158744
Folliculitis	85.40	9.89	11	263610	30066	64205045
Sleep disorder due to general medical condition, insomnia type	84.08	9.89	6	263615	26264	64208847
Alopecia	83.73	9.89	370	263251	165320	64069791
Discomfort	81.20	9.89	128	263493	80750	64154361
Mucosal inflammation	77.20	9.89	85	263536	62499	64172612
Amnesia	76.58	9.89	395	263226	47874	64187237
Hepatocellular injury	76.57	9.89	377	263244	44858	64190253
Disorientation	76.53	9.89	439	263182	55389	64179722
Neutropenic sepsis	75.41	9.89	5	263616	23267	64211844
Platelet count decreased	75.13	9.89	391	263230	167320	64067791
Aggression	73.81	9.89	379	263242	45853	64189258
Stomatitis	72.35	9.89	219	263402	109386	64125725
Dyspnoea	72.14	9.89	2314	261307	716360	63518751
Anaemia	70.79	9.89	1105	262516	377575	63857536
Sinusitis	70.66	9.89	331	263290	145597	64089514
Pancytopenia	70.61	9.89	323	263298	142986	64092125
Suspected suicide	69.46	9.89	126	263495	8528	64226583
Myelosuppression	69.42	9.89	8	263613	23822	64211289
Abnormal behaviour	69.36	9.89	297	263324	33325	64201786
Neutrophil count decreased	66.83	9.89	134	263487	77062	64158049
Condition aggravated	65.86	9.89	1098	262523	371328	63863783
Confusional state	65.63	9.89	1462	262159	259682	63975429
Abdominal discomfort	64.41	9.89	458	263163	181864	64053247
Homicide	63.59	9.89	46	263575	1105	64234006
Hypokinesia	63.52	9.89	180	263441	16416	64218695
Toxicologic test abnormal	63.26	9.89	47	263574	1178	64233933
Gastrointestinal disorder	62.29	9.89	175	263446	89534	64145577
Malignant neoplasm progression	62.01	9.89	244	263377	112627	64122484
Hepatic function abnormal	61.55	9.89	105	263516	64208	64170903
Nervousness	60.91	9.89	261	263360	29295	64205816
Diarrhoea	60.16	9.89	2381	261240	720323	63514788
Dependence	60.13	9.89	58	263563	2097	64233014
Irritability	59.89	9.89	303	263318	36443	64198668
Memory impairment	58.45	9.89	571	263050	85111	64150000
Euphoric mood	58.11	9.89	100	263521	6491	64228620
Psychomotor skills impaired	57.94	9.89	75	263546	3770	64231341
Muscle injury	57.81	9.89	18	263603	26419	64208692
Musculoskeletal stiffness	55.30	9.89	287	263334	122919	64112192
Blood pressure fluctuation	55.06	9.89	79	263542	51792	64183319
Blood creatinine increased	54.57	9.89	328	263293	135454	64099657
Crying	54.07	9.89	193	263428	19897	64215214
Cardiac failure	53.08	9.89	320	263301	132053	64103058
Postmortem blood drug level abnormal	52.94	9.89	33	263588	614	64234497
Substance use disorder	52.54	9.89	27	263594	340	64234771
COVID-19	52.27	9.89	118	263503	65022	64170089
Psychomotor hyperactivity	50.76	9.89	152	263469	14299	64220812
Counterfeit product administered	50.51	9.89	19	263602	104	64235007
Unresponsive to stimuli	50.44	9.89	366	263255	50027	64185084
Impaired healing	49.79	9.89	108	263513	60365	64174746
Acute kidney injury	49.47	9.89	1428	262193	447812	63787299
Drug detoxification	49.29	9.89	23	263598	231	64234880
Fall	48.83	9.89	2126	261495	414700	63820411
Feeling abnormal	48.67	9.89	792	262829	132810	64102301
Alcohol interaction	48.66	9.89	74	263547	4327	64230784
Blister	47.74	9.89	170	263451	80797	64154314
Delirium	47.62	9.89	462	263159	68732	64166379
Pneumocystis jirovecii pneumonia	47.32	9.89	27	263594	27607	64207504
Road traffic accident	46.97	9.89	249	263372	30496	64204615
Haemoglobin decreased	46.61	9.89	541	263080	194522	64040589
Thinking abnormal	45.86	9.89	127	263494	11429	64223682
Blood pressure systolic increased	45.28	9.89	83	263538	49370	64185741
Inflammation	44.88	9.89	128	263493	65172	64169939
Wheezing	44.37	9.89	174	263447	80405	64154706
Herpes zoster	44.24	9.89	170	263451	79017	64156094
Blood pressure diastolic decreased	43.96	9.89	18	263603	22283	64212828
Asthma	43.76	9.89	220	263401	95005	64140106
Anhedonia	43.35	9.89	139	263482	13567	64221544
Vertigo	43.08	9.89	399	263222	58612	64176499
Drug hypersensitivity	43.01	9.89	698	262923	237117	63997994
Medication error	42.82	9.89	350	263271	49616	64185495
Irritable bowel syndrome	42.61	9.89	54	263567	37315	64197796
Sedation	42.57	9.89	303	263318	41159	64193952
Neurotoxicity	42.50	9.89	30	263591	27374	64207737
Product counterfeit	41.93	9.89	20	263601	212	64234899
Transplant rejection	41.51	9.89	10	263611	17391	64217720
Serotonin syndrome	41.46	9.89	289	263332	38993	64196118
Mobility decreased	41.36	9.89	195	263426	85645	64149466
Sluggishness	41.07	9.89	79	263542	5591	64229520
Dysarthria	41.05	9.89	397	263224	59009	64176102
Alcohol use	40.80	9.89	70	263551	4532	64230579
Gastrointestinal haemorrhage	40.79	9.89	345	263276	131967	64103144
Major depression	40.49	9.89	95	263526	7721	64227390
Rheumatoid nodule	40.17	9.89	3	263618	12648	64222463
Ill-defined disorder	39.39	9.89	75	263546	43977	64191134
Obstructive airways disorder	39.21	9.89	23	263598	23162	64211949
Disease progression	39.07	9.89	380	263241	141300	64093811
Red blood cell sedimentation rate increased	38.99	9.89	42	263579	31193	64203918
Pulmonary congestion	38.97	9.89	197	263424	23683	64211428
Anger	38.82	9.89	147	263474	15594	64219517
Poverty of speech	38.68	9.89	26	263595	553	64234558
Mania	38.45	9.89	150	263471	16136	64218975
Hallucination, visual	38.22	9.89	219	263402	27615	64207496
Ascites	38.02	9.89	128	263493	61873	64173238
Self-medication	38.01	9.89	64	263557	4081	64231030
Anaphylactic reaction	37.34	9.89	149	263472	68515	64166596
Electrocardiogram QT prolonged	37.21	9.89	492	263129	78956	64156155
Speech disorder	37.13	9.89	331	263290	48110	64187001
Anticholinergic syndrome	37.03	9.89	50	263571	2619	64232492
Alcohol poisoning	36.78	9.89	64	263557	4191	64230920
Pruritus	36.66	9.89	984	262637	311416	63923695
Skin ulcer	36.64	9.89	78	263543	43896	64191215
Haematochezia	36.11	9.89	144	263477	66229	64168882
Urinary retention	36.08	9.89	333	263288	48868	64186243
Inadequate analgesia	35.92	9.89	61	263560	3917	64231194
Therapy non-responder	35.84	9.89	143	263478	65756	64169355
Panic disorder	35.77	9.89	50	263571	2707	64232404
Drug eruption	35.50	9.89	58	263563	36078	64199033
Cellulitis	35.17	9.89	231	263390	93426	64141685
Emotional distress	34.50	9.89	259	263362	35779	64199332
Body temperature decreased	34.48	9.89	33	263588	25895	64209216
Cerebral haemorrhage	33.76	9.89	102	263519	50988	64184123
Chemical submission	33.30	9.89	17	263604	211	64234900
Asphyxia	33.01	9.89	100	263521	9466	64225645
White blood cell count decreased	32.75	9.89	451	263170	157386	64077725
Alanine aminotransferase increased	32.65	9.89	387	263234	138644	64096467
Blood pressure diastolic abnormal	32.33	9.89	5	263616	11912	64223199
Persistent genital arousal disorder	32.14	9.89	17	263604	228	64234883
Respiratory acidosis	32.13	9.89	101	263520	9754	64225357
Distributive shock	32.12	9.89	39	263582	1836	64233275
Diabetic ketoacidosis	32.12	9.89	45	263576	29800	64205311
Septic shock	32.01	9.89	276	263345	105161	64129950
Urticaria	31.99	9.89	417	263204	146900	64088211
Psoriatic arthropathy	31.87	9.89	82	263539	43199	64191912
Basal cell carcinoma	31.71	9.89	48	263573	30790	64204321
Extrapyramidal disorder	31.70	9.89	161	263460	19391	64215720
Injury	31.52	9.89	359	263262	55633	64179478
Drug withdrawal convulsions	31.27	9.89	41	263580	2087	64233024
Metastases to liver	31.23	9.89	31	263590	23910	64211201
Leukopenia	31.19	9.89	264	263357	100978	64134133
Haemorrhage	31.18	9.89	193	263428	79158	64155953
Exposure during pregnancy	31.00	9.89	188	263433	77487	64157624
Knee arthroplasty	30.80	9.89	39	263582	26960	64208151
Bone marrow failure	30.78	9.89	97	263524	47855	64187256
Abulia	30.73	9.89	27	263594	864	64234247
Pleural effusion	30.60	9.89	350	263271	126209	64108902
Adjustment disorder with mixed anxiety and depressed mood	30.58	9.89	12	263609	75	64235036
Liver function test abnormal	30.37	9.89	132	263489	59269	64175842
Bronchiectasis	30.26	9.89	10	263611	14130	64220981
Intentional product use issue	30.14	9.89	247	263374	95117	64139994
Multiple organ dysfunction syndrome	30.11	9.89	267	263354	101146	64133965
Venoocclusive liver disease	30.10	9.89	3	263618	10012	64225099
Therapeutic response decreased	29.82	9.89	111	263510	52077	64183034
Arthritis	29.35	9.89	211	263410	83603	64151508
Productive cough	29.31	9.89	177	263444	73026	64162085
Bone erosion	29.00	9.89	6	263615	11589	64223522
Acute myeloid leukaemia	28.97	9.89	42	263579	27421	64207690
Osteonecrosis of jaw	28.90	9.89	76	263545	39749	64195362
Narcotic bowel syndrome	28.80	9.89	16	263605	238	64234873
Gun shot wound	28.49	9.89	28	263593	1036	64234075
Interstitial lung disease	28.27	9.89	259	263362	97473	64137638
Respiratory failure	28.16	9.89	476	263145	160707	64074404
Immobilisation prolonged	27.86	9.89	12	263609	98	64235013
Tenosynovitis	27.84	9.89	7	263614	11826	64223285
Aplastic anaemia	27.82	9.89	11	263610	13909	64221202
Pneumonia aspiration	27.73	9.89	367	263254	58904	64176207
Liver disorder	27.62	9.89	118	263503	53233	64181878
Hallucination, auditory	27.12	9.89	139	263482	16800	64218311
Wrong patient	26.99	9.89	14	263607	180	64234931
Tumour lysis syndrome	26.73	9.89	24	263597	19416	64215695
Slow speech	26.52	9.89	37	263584	2000	64233111
Hyperleukocytosis	26.47	9.89	37	263584	2003	64233108
Drug tolerance	26.28	9.89	69	263552	6016	64229095
Toxic epidermal necrolysis	26.16	9.89	72	263549	37094	64198017
Apathy	26.15	9.89	103	263518	11129	64223982
Psychomotor retardation	26.09	9.89	62	263559	5081	64230030
Hallucination	25.93	9.89	430	263191	72358	64162753
Injection site erythema	25.89	9.89	176	263445	70624	64164487
Paramnesia	25.82	9.89	8	263613	21	64235090
Liver function test increased	25.75	9.89	55	263566	30915	64204196
Dysphoria	25.70	9.89	56	263565	4332	64230779
Live birth	25.65	9.89	7	263614	11197	64223914
Tubulointerstitial nephritis	25.61	9.89	55	263566	30854	64204257
Hypervolaemia	25.61	9.89	76	263545	38209	64196902
Thrombocytopenia	25.43	9.89	708	262913	223093	64012018
Fear	25.31	9.89	155	263466	20016	64215095
Aspergillus infection	25.31	9.89	18	263603	16361	64218750
Cyanosis	25.17	9.89	166	263455	21989	64213122
Haemophagocytic lymphohistiocytosis	25.11	9.89	21	263600	17588	64217523
Prescription drug used without a prescription	24.99	9.89	41	263580	2559	64232552
Rheumatic fever	24.99	9.89	4	263617	9290	64225821
Suspected counterfeit product	24.94	9.89	19	263602	495	64234616
Pathogen resistance	24.93	9.89	10	263611	12533	64222578
Heart rate decreased	24.85	9.89	128	263493	54939	64180172
Nephropathy toxic	24.84	9.89	21	263600	17493	64217618
Respiratory rate decreased	24.82	9.89	56	263565	4435	64230676
Cardio-respiratory distress	24.79	9.89	15	263606	264	64234847
Mental disorder	24.72	9.89	189	263432	26256	64208855
Bronchopulmonary aspergillosis	24.56	9.89	25	263596	19060	64216051
Feeling jittery	24.33	9.89	97	263524	10538	64224573
Nightmare	24.28	9.89	158	263463	20835	64214276
Blood lactate dehydrogenase increased	24.10	9.89	63	263558	33015	64202096
Inappropriate schedule of product administration	23.99	9.89	251	263370	92035	64143076
Cholecystitis chronic	23.96	9.89	88	263533	9199	64225912
Multiple injuries	23.94	9.89	46	263575	3253	64231858
Hyporesponsive to stimuli	23.93	9.89	33	263588	1764	64233347
Pain in extremity	23.91	9.89	1004	262617	302081	63933030
Blood bilirubin increased	23.65	9.89	138	263483	57415	64177696
Stevens-Johnson syndrome	23.63	9.89	67	263554	34182	64200929
Injection site pain	23.58	9.89	317	263304	111091	64124020
Impaired driving ability	23.49	9.89	56	263565	4598	64230513
Oropharyngeal pain	23.39	9.89	241	263380	88626	64146485
Hyperhidrosis	23.24	9.89	672	262949	124248	64110863
Exposure via inhalation	23.18	9.89	10	263611	82	64235029
Drug-induced liver injury	23.08	9.89	108	263513	47535	64187576
Full blood count abnormal	22.98	9.89	55	263566	29702	64205409
Fatigue	22.97	9.89	2695	260926	746035	63489076
Myelodysplastic syndrome	22.91	9.89	49	263572	27530	64207581
Hepatotoxicity	22.83	9.89	85	263536	39877	64195234
Pneumonitis	22.76	9.89	117	263504	50248	64184863
Diffuse large B-cell lymphoma	22.75	9.89	7	263614	10354	64224757
Benzodiazepine drug level abnormal	22.52	9.89	5	263616	0	64235111
Angioedema	22.44	9.89	154	263467	61667	64173444
Housebound	22.15	9.89	17	263604	448	64234663
Enthesopathy	22.10	9.89	6	263615	9632	64225479
Lymphadenopathy	21.93	9.89	107	263514	46579	64188532
Homicidal ideation	21.92	9.89	44	263577	3213	64231898
Suicidal behaviour	21.87	9.89	41	263580	2846	64232265
Hallucination, gustatory	21.84	9.89	9	263612	65	64235046
Cerebral infarction	21.72	9.89	90	263531	40954	64194157
Substance abuser	21.38	9.89	10	263611	101	64235010
Bacteraemia	21.38	9.89	49	263572	26862	64208249
Hip arthroplasty	21.22	9.89	34	263587	21317	64213794
Obsessive-compulsive disorder	21.19	9.89	55	263566	4763	64230348
Acquired amegakaryocytic thrombocytopenia	21.18	9.89	6	263615	10	64235101
Renal papillary necrosis	21.15	9.89	15	263606	349	64234762
Hyponatraemic encephalopathy	21.15	9.89	14	263607	290	64234821
Prostate cancer	21.15	9.89	30	263591	19765	64215346
Ankylosing spondylitis	21.14	9.89	4	263617	8230	64226881
Premature delivery	21.05	9.89	27	263594	18562	64216549
Erythema	20.94	9.89	593	263028	186477	64048634
Wrong patient received product	20.89	9.89	47	263574	3715	64231396
Generalised anxiety disorder	20.89	9.89	32	263589	1883	64233228
Femur fracture	20.57	9.89	71	263550	34064	64201047
Withdrawal catatonia	20.51	9.89	11	263610	152	64234959
Obsessive thoughts	20.51	9.89	23	263598	994	64234117
Hypochloraemia	20.49	9.89	33	263588	2028	64233083
Injection site swelling	20.47	9.89	93	263528	41260	64193851
Adrenal insufficiency	20.35	9.89	38	263583	22449	64212662
Blood test abnormal	20.29	9.89	14	263607	12929	64222182
Epstein-Barr virus infection	20.26	9.89	13	263608	12475	64222636
Tension	20.25	9.89	47	263574	3793	64231318
Hypersomnia	20.18	9.89	144	263477	19573	64215538
Mood altered	20.18	9.89	123	263498	15856	64219255
Haematotoxicity	20.15	9.89	14	263607	12882	64222229
Electrocardiogram QRS complex prolonged	20.11	9.89	83	263538	9161	64225950
Upper gastrointestinal haemorrhage	20.06	9.89	75	263546	35145	64199966
Delusion	19.88	9.89	134	263487	17880	64217231
Vestibular ischaemia	19.86	9.89	6	263615	14	64235097
Stupor	19.81	9.89	62	263559	5973	64229138
Drug tolerance increased	19.80	9.89	18	263603	603	64234508
Prothrombin time shortened	19.79	9.89	39	263582	2810	64232301
Hallucinations, mixed	19.71	9.89	62	263559	5990	64229121
Blood pressure systolic abnormal	19.64	9.89	8	263613	9934	64225177
Head injury	19.59	9.89	213	263408	32629	64202482
Inappropriate antidiuretic hormone secretion	19.56	9.89	157	263464	22132	64212979
Hospitalisation	19.36	9.89	205	263416	75002	64160109
Clostridium difficile infection	19.33	9.89	79	263542	36084	64199027
Joint effusion	19.30	9.89	16	263605	13457	64221654
Substance dependence	19.25	9.89	16	263605	474	64234637
Atrial fibrillation	19.23	9.89	542	263079	170547	64064564
Depressed mood	19.20	9.89	254	263367	40758	64194353
Affect lability	18.99	9.89	80	263541	8910	64226201
Purging	18.97	9.89	7	263614	36	64235075
Cutaneous T-cell dyscrasia	18.93	9.89	8	263613	62	64235049
Feeling of despair	18.87	9.89	36	263585	2532	64232579
Acute myocardial infarction	18.79	9.89	188	263433	69530	64165581
Partner stress	18.69	9.89	13	263608	293	64234818
Tonic clonic movements	18.62	9.89	31	263590	1958	64233153
Accident	18.62	9.89	66	263555	6780	64228331
Mouth ulceration	18.54	9.89	69	263552	32375	64202736
Metastases to lung	18.53	9.89	21	263600	15243	64219868
Bipolar I disorder	18.49	9.89	29	263592	1742	64233369
Second primary malignancy	18.49	9.89	14	263607	12323	64222788
Hypocalcaemia	18.31	9.89	98	263523	41655	64193456
Compartment syndrome	18.29	9.89	48	263573	4184	64230927
Analgesic drug level increased	18.15	9.89	33	263588	2237	64232874
Dermatitis allergic	18.11	9.89	21	263600	15088	64220023
Abdominal pain	17.98	9.89	1069	262552	311306	63923805
Grip strength decreased	17.96	9.89	13	263608	11711	64223400
Brachial plexus injury	17.89	9.89	9	263612	108	64235003
Prothrombin level decreased	17.88	9.89	26	263595	1460	64233651
Cholangitis	17.87	9.89	11	263610	10791	64224320
Self-injurious ideation	17.82	9.89	40	263581	3157	64231954
Arthritis bacterial	17.75	9.89	5	263616	7834	64227277
Necrosis ischaemic	17.75	9.89	21	263600	962	64234149
Conversion disorder	17.74	9.89	28	263593	1691	64233420
Blood alcohol increased	17.72	9.89	23	263598	1159	64233952
Blood pressure diastolic increased	17.71	9.89	11	263610	10741	64224370
COVID-19 pneumonia	17.64	9.89	25	263596	16479	64218632
Pain	17.62	9.89	1987	261634	551524	63683587
Feeling of relaxation	17.47	9.89	9	263612	114	64234997
Myocardial infarction	17.46	9.89	530	263091	165291	64069820
Drug interaction	17.42	9.89	1712	261909	360371	63874740
Ulcer	17.36	9.89	43	263578	22947	64212164
Puncture site haematoma	17.31	9.89	10	263611	161	64234950
Multiple-drug resistance	17.03	9.89	3	263618	6499	64228612
Multiple sclerosis	16.94	9.89	134	263487	18807	64216304
Subarachnoid haemorrhage	16.83	9.89	31	263590	18407	64216704
Hyperthermia	16.76	9.89	115	263506	15435	64219676
Foot deformity	16.67	9.89	26	263595	16478	64218633
Body temperature increased	16.67	9.89	85	263536	36581	64198530
Sarcomatoid carcinoma	16.56	9.89	6	263615	29	64235082
Cystitis haemorrhagic	16.38	9.89	6	263615	7950	64227161
Sputum discoloured	16.32	9.89	30	263591	17826	64217285
Poor venous access	16.28	9.89	16	263605	12401	64222710
Anamnestic reaction	16.24	9.89	6	263615	31	64235080
Acute graft versus host disease in skin	16.23	9.89	4	263617	6851	64228260
Therapy partial responder	16.18	9.89	11	263610	10237	64224874
Bladder dilatation	16.17	9.89	28	263593	1826	64233285
Osteonecrosis	16.15	9.89	60	263561	28169	64206942
Somnambulism	16.13	9.89	52	263569	5089	64230022
Tendonitis	16.05	9.89	37	263584	20245	64214866
Rhinorrhoea	16.04	9.89	162	263459	59807	64175304
Influenza	15.98	9.89	323	263298	106208	64128903
Bacterial prostatitis	15.96	9.89	7	263614	60	64235051
Hypervigilance	15.94	9.89	14	263607	448	64234663
Hypersensitivity vasculitis	15.90	9.89	4	263617	6757	64228354
Learning disorder	15.81	9.89	15	263606	531	64234580
Cardiac valve disease	15.81	9.89	52	263569	5143	64229968
Papillary muscle disorder	15.79	9.89	4	263617	3	64235108
LDL/HDL ratio increased	15.79	9.89	4	263617	3	64235108
Pulmonary tuberculosis	15.72	9.89	5	263616	7239	64227872
Graft versus host disease	15.71	9.89	20	263601	13793	64221318
Neuropathy peripheral	15.70	9.89	363	263258	117162	64117949
Device related infection	15.69	9.89	68	263553	30558	64204553
Morbid thoughts	15.64	9.89	17	263604	709	64234402
Jaundice	15.62	9.89	125	263496	48387	64186724
Substance use	15.59	9.89	16	263605	624	64234487
Incoherent	15.55	9.89	64	263557	7054	64228057
Angina pectoris	15.53	9.89	114	263507	44967	64190144
Muscle spasms	15.51	9.89	715	262906	140308	64094803
Hyperreflexia	15.41	9.89	64	263557	7084	64228027
Hypercalcaemia	15.34	9.89	71	263550	31345	64203766
Pulmonary oedema	15.12	9.89	425	263196	78249	64156862
Pregnancy	15.00	9.89	40	263581	20825	64214286
Drug screen negative	14.97	9.89	11	263610	271	64234840
Dyssomnia	14.97	9.89	6	263615	40	64235071
Cytokine release syndrome	14.92	9.89	40	263581	20789	64214322
Fear of injection	14.91	9.89	3	263618	5909	64229202
Drug tolerance decreased	14.88	9.89	5	263616	6993	64228118
Uveitis	14.87	9.89	18	263603	12690	64222421
Tarsal tunnel syndrome	14.87	9.89	14	263607	491	64234620
Victim of crime	14.85	9.89	13	263608	414	64234697
Squamous cell carcinoma of skin	14.79	9.89	16	263605	11860	64223251
Throat irritation	14.78	9.89	76	263545	32635	64202476
BK virus infection	14.58	9.89	6	263615	7406	64227705
Needle issue	14.58	9.89	10	263611	9262	64225849
Epistaxis	14.58	9.89	298	263323	97833	64137278
Logorrhoea	14.54	9.89	43	263578	4016	64231095
Restlessness	14.53	9.89	236	263385	39549	64195562
Alanine aminotransferase abnormal	14.51	9.89	5	263616	6883	64228228
Brain oedema	14.50	9.89	146	263475	21929	64213182
Lip swelling	14.49	9.89	74	263547	31833	64203278
Cerebral congestion	14.48	9.89	6	263615	44	64235067
Gambling disorder	14.47	9.89	27	263594	1867	64233244
Intrusive thoughts	14.45	9.89	12	263609	355	64234756
Blood parathyroid hormone decreased	14.43	9.89	6	263615	7360	64227751
Cataract	14.33	9.89	137	263484	51125	64183986
Blood triglycerides decreased	14.27	9.89	9	263612	171	64234940
Cerebral microangiopathy	14.20	9.89	10	263611	230	64234881
Sleep disorder due to a general medical condition	14.16	9.89	8	263613	8226	64226885
Alcohol withdrawal syndrome	14.15	9.89	26	263595	1777	64233334
Self esteem decreased	13.99	9.89	18	263603	899	64234212
Immunosuppression	13.92	9.89	14	263607	10732	64224379
Hyperkalaemia	13.89	9.89	311	263310	100818	64134293
Drug diversion	13.85	9.89	20	263601	1116	64233995
Gamma-glutamyltransferase increased	13.83	9.89	129	263492	48381	64186730
Electrocardiogram QRS complex shortened	13.79	9.89	15	263606	626	64234485
Blood pressure increased	13.71	9.89	571	263050	171981	64063130
Localised infection	13.67	9.89	70	263551	30091	64205020
Amimia	13.53	9.89	6	263615	53	64235058
Haemorrhage intracranial	13.51	9.89	51	263570	23833	64211278
Colitis	13.51	9.89	164	263457	58510	64176601
Encephalitis	13.48	9.89	19	263602	12552	64222559
Pulmonary alveolar haemorrhage	13.42	9.89	12	263609	9726	64225385
Panniculitis	13.40	9.89	10	263611	8869	64226242
Bipolar disorder	13.39	9.89	59	263562	6702	64228409
Ligament sprain	13.37	9.89	83	263538	10769	64224342
Cognitive disorder	13.36	9.89	307	263314	54780	64180331
Brain death	13.34	9.89	47	263574	4814	64230297
Hyperinsulinism	13.34	9.89	4	263617	9	64235102
Aplasia pure red cell	13.29	9.89	6	263615	7008	64228103
Catatonia	13.24	9.89	64	263557	7556	64227555
Judgement impaired	13.24	9.89	19	263602	1054	64234057
Coma scale	13.24	9.89	6	263615	56	64235055
Lupus-like syndrome	13.14	9.89	10	263611	8781	64226330
Appendicitis	13.12	9.89	22	263599	13547	64221564
Refusal of treatment by patient	13.05	9.89	68	263553	8271	64226840
Blood pressure decreased	13.03	9.89	261	263360	85938	64149173
Palmar-plantar erythrodysaesthesia syndrome	12.99	9.89	67	263554	28752	64206359
Joint stiffness	12.98	9.89	72	263549	30332	64204779
Wrong rate	12.97	9.89	6	263615	59	64235052
Hair texture abnormal	12.91	9.89	34	263587	2970	64232141
Graft versus host disease in skin	12.90	9.89	3	263618	5344	64229767
Oedematous pancreatitis	12.88	9.89	17	263604	871	64234240
Meningioma	12.85	9.89	40	263581	3842	64231269
Cystitis	12.82	9.89	112	263509	42563	64192548
Myocarditis	12.77	9.89	32	263589	17011	64218100
Osteoarthritis	12.76	9.89	182	263439	63154	64171957
Formication	12.72	9.89	43	263578	4314	64230797
Tubulointerstitial nephritis and uveitis syndrome	12.70	9.89	10	263611	274	64234837
Product substitution issue	12.65	9.89	120	263501	17741	64217370
Product complaint	12.64	9.89	88	263533	11866	64223245
Myopathy	12.63	9.89	34	263587	17646	64217465
Abnormal dreams	12.63	9.89	79	263542	10277	64224834
Blood creatine phosphokinase	12.61	9.89	7	263614	104	64235007
Large intestine perforation	12.59	9.89	20	263601	12584	64222527
Aspartate aminotransferase increased	12.58	9.89	383	263238	119405	64115706
Haematemesis	12.55	9.89	127	263494	46872	64188239
Peritonitis	12.55	9.89	56	263565	24967	64210144
Haemolysis	12.53	9.89	16	263605	11023	64224088
Device malfunction	12.53	9.89	34	263587	17599	64217512
Neoplasm progression	12.53	9.89	107	263514	40857	64194254
Mental status changes	12.48	9.89	333	263288	60829	64174282
Pneumatosis intestinalis	12.48	9.89	3	263618	5226	64229885
Pulmonary toxicity	12.47	9.89	10	263611	8551	64226560
Leukoencephalopathy	12.46	9.89	59	263562	6908	64228203
Hyponatraemia	12.43	9.89	733	262888	147606	64087505
Hypothermia	12.41	9.89	130	263491	19726	64215385
Incision site pain	12.40	9.89	31	263590	2623	64232488
Musculoskeletal disorder	12.37	9.89	35	263586	17871	64217240
Therapeutic response shortened	12.33	9.89	14	263607	10156	64224955
Pneumonia bacterial	12.25	9.89	27	263594	15008	64220103
Hypercapnia	12.22	9.89	63	263558	7631	64227480
Cushingoid	12.22	9.89	8	263613	7595	64227516
Urinary tract infection	12.20	9.89	799	262822	230797	64004314
Polyarthritis	12.19	9.89	13	263608	9702	64225409
Proteinuria	12.19	9.89	65	263556	27658	64207453
Cytomegalovirus test positive	12.18	9.89	3	263618	5141	64229970
Substance-induced mood disorder	12.15	9.89	7	263614	112	64234999
Chloasma	12.15	9.89	5	263616	36	64235075
Burning sensation	12.11	9.89	277	263344	49387	64185724
Pulmonary fibrosis	12.08	9.89	72	263549	29806	64205305
Legal problem	12.07	9.89	8	263613	166	64234945
Vestibular disorder	12.02	9.89	28	263593	2265	64232846
Red blood cell count decreased	12.01	9.89	133	263488	48253	64186858
Panic reaction	11.98	9.89	40	263581	3987	64231124
Osteoporosis	11.96	9.89	112	263509	41968	64193143
Cardiac failure congestive	11.93	9.89	425	263196	130155	64104956
International normalised ratio increased	11.88	9.89	240	263381	78927	64156184
Blastocystis infection	11.85	9.89	4	263617	15	64235096
Transfusion	11.83	9.89	36	263585	17958	64217153
Peripheral nerve paresis	11.81	9.89	5	263616	39	64235072
Nephrotic syndrome	11.79	9.89	13	263608	9554	64225557
Eosinophil count increased	11.78	9.89	25	263596	14087	64221024
Physical assault	11.76	9.89	22	263599	1524	64233587
Initial insomnia	11.76	9.89	51	263570	5753	64229358
Chronic fatigue syndrome	11.70	9.89	19	263602	1176	64233935
Pneumoconiosis	11.67	9.89	9	263612	239	64234872
Nodular rash	11.65	9.89	10	263611	310	64234801
Foreign body	11.63	9.89	29	263592	2450	64232661
Infective pulmonary exacerbation of cystic fibrosis	11.52	9.89	19	263602	11777	64223334
Staphylococcal sepsis	11.50	9.89	22	263599	12877	64222234
Benign mesenteric neoplasm	11.45	9.89	3	263618	3	64235108
Cutaneous lymphoma	11.45	9.89	9	263612	246	64234865
Osteomyelitis	11.41	9.89	66	263555	27521	64207590
Vascular headache	11.39	9.89	5	263616	43	64235068
Loss of personal independence in daily activities	11.37	9.89	218	263403	72236	64162875
Product quality issue	11.34	9.89	178	263443	29621	64205490
Disinhibition	11.33	9.89	27	263594	2216	64232895
Suspiciousness	11.30	9.89	13	263608	578	64234533
Reduced facial expression	11.29	9.89	26	263595	2087	64233024
Femoral artery aneurysm	11.29	9.89	8	263613	186	64234925
Periorbital haematoma	11.26	9.89	16	263605	880	64234231
Face injury	11.23	9.89	33	263588	3072	64232039
Foaming at mouth	11.21	9.89	23	263598	1706	64233405
Product substitution	11.18	9.89	6	263615	83	64235028
Photophobia	11.18	9.89	114	263507	17179	64217932
Rash erythematous	11.17	9.89	136	263485	48497	64186614
Paranoia	11.15	9.89	109	263512	16243	64218868
Alcoholism	11.12	9.89	35	263586	3382	64231729
Faeces soft	11.10	9.89	5	263616	5850	64229261
Haematuria	11.07	9.89	177	263444	60294	64174817
Post-traumatic stress disorder	10.98	9.89	40	263581	4165	64230946
Inflammatory marker increased	10.96	9.89	11	263610	8440	64226671
Sudden death	10.93	9.89	128	263493	19968	64215143
Creatinine renal clearance decreased	10.87	9.89	27	263594	14394	64220717
Cholestasis	10.86	9.89	250	263371	44622	64190489
Multiple sclerosis relapse	10.84	9.89	232	263389	40903	64194208
Hypoventilation	10.84	9.89	51	263570	5955	64229156
Electroencephalogram abnormal	10.76	9.89	46	263575	5157	64229954
Myoclonus	10.71	9.89	153	263468	24965	64210146
Skin necrosis	10.66	9.89	27	263594	14302	64220809
Death of relative	10.62	9.89	8	263613	205	64234906
Cyclothymic disorder	10.62	9.89	8	263613	205	64234906
Myositis	10.60	9.89	33	263588	16344	64218767
Central nervous system necrosis	10.59	9.89	9	263612	275	64234836
Skin toxicity	10.54	9.89	7	263614	6595	64228516
Apraxia	10.48	9.89	28	263593	2467	64232644
Thrombotic microangiopathy	10.47	9.89	34	263587	16621	64218490
Food allergy	10.43	9.89	10	263611	7841	64227270
Enterococcal infection	10.42	9.89	26	263595	13840	64221271
Frequent bowel movements	10.41	9.89	39	263582	18266	64216845
Tumour hyperprogression	10.37	9.89	7	263614	150	64234961
Biliary dyskinesia	10.35	9.89	27	263594	2345	64232766
Pneumonia viral	10.35	9.89	10	263611	7812	64227299
Wound infection	10.31	9.89	29	263592	14835	64220276
Gallbladder hypofunction	10.27	9.89	11	263610	451	64234660
Progressive multifocal leukoencephalopathy	10.27	9.89	39	263582	18193	64216918
Accidental poisoning	10.22	9.89	20	263601	1433	64233678
Fistula	10.22	9.89	15	263606	9746	64225365
Injection site pruritus	10.19	9.89	102	263519	37724	64197387
Hypophagia	10.15	9.89	108	263513	39479	64195632
Myotonia	10.13	9.89	8	263613	220	64234891
Skin plaque	10.11	9.89	13	263608	8927	64226184
Nephrolithiasis	10.09	9.89	122	263499	43561	64191550
Phobia	10.09	9.89	10	263611	374	64234737
Metastases to bone	10.09	9.89	46	263575	20389	64214722
Dysuria	10.08	9.89	234	263387	41823	64193288
Torsade de pointes	10.07	9.89	112	263509	17251	64217860
Respiratory tract infection	10.02	9.89	101	263520	37306	64197805
Immune thrombocytopenia	10.01	9.89	30	263591	15036	64220075
Conjunctivitis	9.94	9.89	46	263575	20308	64214803
Blood lactic acid increased	9.93	9.89	17	263604	10384	64224727
Laparoscopy	9.93	9.89	3	263618	7	64235104

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	N05BA12	NERVOUS SYSTEM PSYCHOLEPTICS ANXIOLYTICS Benzodiazepine derivatives
FDA CS	M0002356	Benzodiazepines
CHEBI has role	CHEBI:35474	anti-anxiety agents
CHEBI has role	CHEBI:35623	anticonvulsants
CHEBI has role	CHEBI:35703	Xenobiotic
CHEBI has role	CHEBI:35717	hypnotics
CHEBI has role	CHEBI:51371	muscle relaxants
CHEBI has role	CHEBI:51373	gamma-aminobutyric acid receptor agonist
MeSH PA	D014151	Anti-Anxiety Agents
MeSH PA	D002491	Central Nervous System Agents
MeSH PA	D002492	Central Nervous System Depressants
MeSH PA	D018682	GABA Agents
MeSH PA	D018757	GABA Modulators
MeSH PA	D006993	Hypnotics and Sedatives
MeSH PA	D018377	Neurotransmitter Agents
MeSH PA	D011619	Psychotropic Drugs
MeSH PA	D014149	Tranquilizing Agents
FDA EPC	N0000175694	Benzodiazepine

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Generalized anxiety disorder	indication	21897009	DOID:14320
Anxiety	indication	48694002
Mixed anxiety and depressive disorder	indication	231504006
Panic disorder	indication	371631005	DOID:594
Insomnia	off-label use	193462001
Suicidal thoughts	contraindication	6471006
Asthenia	contraindication	13791008
Alcohol intoxication	contraindication	25702006
Depressive disorder	contraindication	35489007
Substance abuse	contraindication	66214007
Sleep apnea	contraindication	73430006	DOID:0050847
Open-angle glaucoma	contraindication	84494001	DOID:1067
Kidney disease	contraindication	90708001	DOID:557
Disease of liver	contraindication	235856003	DOID:409
Syncope	contraindication	271594007
Pregnancy, function	contraindication	289908002
Angle-closure glaucoma	contraindication	392291006	DOID:13550
Breastfeeding (mother)	contraindication	413712001
Chronic lung disease	contraindication	413839001
Obesity	contraindication	414916001	DOID:9970
Central nervous system depression	contraindication	418072004
Smokes tobacco daily	contraindication	449868002

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	6.15	Basic
pKa2	4.9	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source	MoA source
GABA-A receptor alpha-5/beta-3/gamma-2	Ion channel	P18507 P28472 P31644	GBRG2_HUMAN GBRB3_HUMAN GBRA5_HUMAN	POSITIVE ALLOSTERIC MODULATOR	EC50	8	WOMBAT-PK	CHEMBL
GABA-A receptor alpha-1/beta-2/gamma-2	Ion channel	P14867 P18507 P47870	GBRA1_HUMAN GBRG2_HUMAN GBRB2_HUMAN	POSITIVE ALLOSTERIC MODULATOR	EC50	7.43	WOMBAT-PK	CHEMBL
GABA-A receptor alpha-2/beta-3/gamma-2	Ion channel	P18507 P28472 P47869	GBRG2_HUMAN GBRB3_HUMAN GBRA2_HUMAN	POSITIVE ALLOSTERIC MODULATOR	EC50	7.92	WOMBAT-PK	CHEMBL
GABA-A receptor alpha-3/beta-3/gamma-2	Ion channel	P18507 P28472 P34903	GBRG2_HUMAN GBRB3_HUMAN GBRA3_HUMAN	POSITIVE ALLOSTERIC MODULATOR	EC50	7.16	WOMBAT-PK	CHEMBL
Cytochrome P450 3A4	Enzyme	P08684	CP3A4_HUMAN		Ki	3.85	WOMBAT-PK
Platelet-activating factor receptor	GPCR	P25105	PTAFR_HUMAN		Ki	5.46	PDSP
Bromodomain-containing protein 4	Unclassified	O60885	BRD4_HUMAN		Kd	5.61	CHEMBL
Cholecystokinin receptor type A	GPCR		CCKAR_RAT		IC50	4.19	CHEMBL

External reference:

ID	Source
D00225	KEGG_DRUG
202363	RXNORM
C0002333	UMLSCUI
CHEBI:2611	CHEBI
08H	PDB_CHEM_ID
CHEMBL661	ChEMBL_ID
DB00404	DRUGBANK_ID
D000525	MESH_DESCRIPTOR_UI
2118	PUBCHEM_CID
7111	IUPHAR_LIGAND_ID
3426	INN_ID
YU55MQ3IZY	UNII
1327	MMSL
1885	MMSL
4153	MMSL
d00168	MMSL
001464	NDDF
4018074	VANDF
111127002	SNOMEDCT_US
386983007	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Xanax	HUMAN PRESCRIPTION DRUG LABEL	1	0009-0029	TABLET	0.25 mg	ORAL	NDA	36 sections
Xanax	HUMAN PRESCRIPTION DRUG LABEL	1	0009-0055	TABLET	0.50 mg	ORAL	NDA	36 sections
Xanax XR	HUMAN PRESCRIPTION DRUG LABEL	1	0009-0057	TABLET, EXTENDED RELEASE	0.50 mg	ORAL	NDA	37 sections
Xanax XR	HUMAN PRESCRIPTION DRUG LABEL	1	0009-0057	TABLET, EXTENDED RELEASE	0.50 mg	ORAL	NDA	37 sections
Xanax XR	HUMAN PRESCRIPTION DRUG LABEL	1	0009-0059	TABLET, EXTENDED RELEASE	1 mg	ORAL	NDA	37 sections
Xanax XR	HUMAN PRESCRIPTION DRUG LABEL	1	0009-0059	TABLET, EXTENDED RELEASE	1 mg	ORAL	NDA	37 sections
Xanax XR	HUMAN PRESCRIPTION DRUG LABEL	1	0009-0066	TABLET, EXTENDED RELEASE	2 mg	ORAL	NDA	37 sections
Xanax XR	HUMAN PRESCRIPTION DRUG LABEL	1	0009-0066	TABLET, EXTENDED RELEASE	2 mg	ORAL	NDA	37 sections
Xanax XR	HUMAN PRESCRIPTION DRUG LABEL	1	0009-0068	TABLET, EXTENDED RELEASE	3 mg	ORAL	NDA	37 sections
Xanax XR	HUMAN PRESCRIPTION DRUG LABEL	1	0009-0068	TABLET, EXTENDED RELEASE	3 mg	ORAL	NDA	37 sections
Xanax	HUMAN PRESCRIPTION DRUG LABEL	1	0009-0090	TABLET	1 mg	ORAL	NDA	36 sections
Xanax	HUMAN PRESCRIPTION DRUG LABEL	1	0009-0094	TABLET	2 mg	ORAL	NDA	36 sections
Alprazolam	HUMAN PRESCRIPTION DRUG LABEL	1	0054-3068	SOLUTION, CONCENTRATE	1 mg	ORAL	ANDA	16 sections
Alprazolam	HUMAN PRESCRIPTION DRUG LABEL	1	0228-2027	TABLET	0.25 mg	ORAL	ANDA	29 sections
Alprazolam	HUMAN PRESCRIPTION DRUG LABEL	1	0228-2027	TABLET	0.25 mg	ORAL	ANDA	29 sections
Alprazolam	HUMAN PRESCRIPTION DRUG LABEL	1	0228-2029	TABLET	0.50 mg	ORAL	ANDA	29 sections
Alprazolam	HUMAN PRESCRIPTION DRUG LABEL	1	0228-2029	TABLET	0.50 mg	ORAL	ANDA	29 sections
Alprazolam	HUMAN PRESCRIPTION DRUG LABEL	1	0228-2031	TABLET	1 mg	ORAL	ANDA	29 sections
Alprazolam	HUMAN PRESCRIPTION DRUG LABEL	1	0228-2031	TABLET	1 mg	ORAL	ANDA	29 sections
Alprazolam	HUMAN PRESCRIPTION DRUG LABEL	1	0228-2039	TABLET	2 mg	ORAL	ANDA	29 sections
Alprazolam	HUMAN PRESCRIPTION DRUG LABEL	1	0228-2039	TABLET	2 mg	ORAL	ANDA	29 sections
AlprazolamExtended Release	HUMAN PRESCRIPTION DRUG LABEL	1	0228-3083	TABLET, EXTENDED RELEASE	0.50 mg	ORAL	ANDA	29 sections
AlprazolamExtended Release	HUMAN PRESCRIPTION DRUG LABEL	1	0228-3084	TABLET, EXTENDED RELEASE	1 mg	ORAL	ANDA	29 sections
AlprazolamExtended Release	HUMAN PRESCRIPTION DRUG LABEL	1	0228-3086	TABLET, EXTENDED RELEASE	3 mg	ORAL	ANDA	29 sections
AlprazolamExtended Release	HUMAN PRESCRIPTION DRUG LABEL	1	0228-3087	TABLET, EXTENDED RELEASE	2 mg	ORAL	ANDA	29 sections
Alprazolam	HUMAN PRESCRIPTION DRUG LABEL	1	0228-4019	TABLET, ORALLY DISINTEGRATING	0.25 mg	ORAL	ANDA	31 sections
Alprazolam	HUMAN PRESCRIPTION DRUG LABEL	1	0228-4022	TABLET, ORALLY DISINTEGRATING	0.50 mg	ORAL	ANDA	31 sections
Alprazolam	HUMAN PRESCRIPTION DRUG LABEL	1	0228-4024	TABLET, ORALLY DISINTEGRATING	1 mg	ORAL	ANDA	31 sections
Alprazolam	HUMAN PRESCRIPTION DRUG LABEL	1	0228-4025	TABLET, ORALLY DISINTEGRATING	2 mg	ORAL	ANDA	31 sections
Alprazolam	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8215	TABLET	0.25 mg	ORAL	ANDA	29 sections