omoconazole 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
systemic antifungal agents, miconazole derivatives 1991 74512-12-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • omoconazole
  • omoconazole nitrate
  • omoconazole mononitrate
  • CM-8282
an imidazole antifungal which inhibits the cytochrome P450-dependent enzymes, resulting in impairment of ergosterol synthesis in fungal cell membranes
  • Molecular weight: 423.72
  • Formula: C20H17Cl3N2O2
  • CLOGP: 6.06
  • LIPINSKI: 1
  • HAC: 4
  • HDO: 0
  • TPSA: 36.28
  • ALOGS: -5.66
  • ROTB: 7

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2B,AXL,BRAF,BTK,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,ERBB2,GRK2,ITK,MAP3K7,MAPK7,MAPK9,NTRK2,PDK2,PDK4,PIK3CB,PIK3CG,PRKDC,SIK2,STK33,TEK,TTK 26
kinase-selectivity-class AXL,BRAF,EIF2AK3,ERBB2,GRK2,PDK4 6
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC D01AC13 DERMATOLOGICALS
ANTIFUNGALS FOR DERMATOLOGICAL USE
ANTIFUNGALS FOR TOPICAL USE
Imidazole and triazole derivatives
ATC G01AF16 GENITO URINARY SYSTEM AND SEX HORMONES
GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS
ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS
Imidazole derivatives
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000935 Antifungal Agents

Related Drugs by ATC class:

D01AC Imidazole and triazole derivatives 20 drugs
bifonazolechlormidazoleclotrimazoleeberconazoleeconazoleefinaconazolefenticonazolefluconazoleflutrimazoleisoconazoleketoconazolelanoconazole show all 20 →
G01AF Imidazole derivatives 16 drugs
azanidazolebutoconazoleclotrimazoleeconazolefenticonazoleflutrimazoleisoconazoleketoconazolemetronidazolemiconazoleornidazoleoxiconazole show all 16 →

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Dermatophytosis indication 47382004 DOID:8913
Candidiasis of skin indication 49883006
Pityriasis versicolor indication 56454009 DOID:9060
Candidal vulvovaginitis indication 72605008 DOID:2272




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 6.1 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D01664 KEGG_DRUG
C0069488 UMLSCUI
CHEBI:135685 CHEBI
CHEMBL2046550 ChEMBL_ID
CHEMBL2107140 ChEMBL_ID
DB13684 DRUGBANK_ID
C050566 MESH_SUPPLEMENTAL_RECORD_UI
3033988 PUBCHEM_CID
4991 INN_ID
83621-06-1 SECONDARY_CAS_RN
GQ8ADD54E1 UNII
134933 RXNORM
005693 NDDF
005694 NDDF
763190008 SNOMEDCT_US
763191007 SNOMEDCT_US

Pharmaceutical products:

None