butoconazole Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
systemic antifungal agents, miconazole derivatives 450 64872-77-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • butoconazole
  • butaconazole
  • butoconazole nitrate
  • butaconazole nitrate
  • femstat
  • Molecular weight: 411.77
  • Formula: C19H17Cl3N2S
  • CLOGP: 6.86
  • LIPINSKI: 1
  • HAC: 2
  • HDO: 0
  • TPSA: 17.82
  • ALOGS: -5.70
  • ROTB: 7

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.10 g V

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Dec. 21, 1995 FDA BAYER

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC G01AF15 GENITO URINARY SYSTEM AND SEX HORMONES
GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS
ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS
Imidazole derivatives
FDA CS M0002083 Azoles
FDA EPC N0000175487 Azole Antifungal
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000935 Antifungal Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Candidal vulvovaginitis indication 72605008 DOID:2272

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 6.45 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Lanosterol 14-alpha demethylase Enzyme INHIBITOR CHEMBL CHEMBL

External reference:

IDSource
4019649 VUID
N0000147742 NUI
D00880 KEGG_DRUG
64872-76-0 SECONDARY_CAS_RN
4018431 VANDF
4019649 VANDF
C0054259 UMLSCUI
CHEBI:3240 CHEBI
CHEMBL1295 ChEMBL_ID
CHEMBL1200398 ChEMBL_ID
DB00639 DRUGBANK_ID
4496 INN_ID
C017125 MESH_SUPPLEMENTAL_RECORD_UI
47472 PUBCHEM_CID
0Q771797PH UNII
19884 RXNORM
4314 MMSL
9794 MMSL
002928 NDDF
004962 NDDF
372878005 SNOMEDCT_US
84844007 SNOMEDCT_US
85433002 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
gynazole 1 HUMAN PRESCRIPTION DRUG LABEL 1 45802-396 CREAM 100 mg VAGINULLL ANDA 19 sections