DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
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L1000
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DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
Search
Structure 🔎
Similarity 🔎
Smart API
Redial
About
Download
L1000
FAQ
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All
FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
butoconazole 🐶
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
systemic antifungal agents, miconazole derivatives
450
64872-77-1
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
butoconazole
butaconazole
butoconazole nitrate
butaconazole nitrate
femstat
Molecular weight: 411.77
Formula: C19H17Cl3N2S
CLOGP: 6.87
LIPINSKI: 1
HAC: 2
HDO: 0
TPSA: 17.82
ALOGS: -5.70
ROTB: 7
Status: OFP
Legend:
OFP - off patent
OFM - off market
ONP - on patent
Drug dosage:
Dose
Unit
Route
0.10
g
V
ADMET properties:
None
Approvals:
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Date
Agency
Company
Orphan
Dec. 21, 1995
FDA
BAYER
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1
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FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
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Source
Code
Description
ATC
G01AF15
GENITO URINARY SYSTEM AND SEX HORMONES
GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS
ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS
Imidazole derivatives
FDA CS
M0002083
Azoles
FDA EPC
N0000175487
Azole Antifungal
MeSH PA
D000890
Anti-Infective Agents
MeSH PA
D000935
Antifungal Agents
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Drug Use
| Suggest Off label Use Form|
|View source of the data|
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Disease
Relation
SNOMED_ID
DOID
Candidal vulvovaginitis
indication
72605008
DOID:2272
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🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
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Dissociation level
Dissociation constant
Type (acidic/basic)
pKa1
6.45
Basic
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Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
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Target
Class
Pharos
UniProt
Action
Type
Activity value
(-log[M])
Mechanism
action
Bioact source
MoA source
Lanosterol 14-alpha demethylase
Enzyme
CP51_CANAL
INHIBITOR
CHEMBL
CHEMBL
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External reference:
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entries
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ID
Source
002928
NDDF
004962
NDDF
0Q771797PH
UNII
19884
RXNORM
372878005
SNOMEDCT_US
4018431
VANDF
4019649
VUID
4019649
VANDF
4314
MMSL
4496
INN_ID
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Pharmaceutical products:
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Product
Category
Ingredients
NDC
Form
Quantity
Route
Marketing
Label
gynazole 1
HUMAN PRESCRIPTION DRUG LABEL
1
45802-396
CREAM
100 mg
VAGINAL
ANDA
19 sections
gynazole 1
HUMAN PRESCRIPTION DRUG LABEL
1
45802-396
CREAM
100 mg
VAGINAL
ANDA
19 sections
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Structure 🔎
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L1000
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butoconazole