All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

ethanol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	1076	64-17-5

Description:

Molecule

Description

Molfile Inchi Smiles Synonyms: alcohol ethanol ethyl alcohol grain alcohol

A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in ALCOHOLIC BEVERAGES. Molecular weight: 46.07 Formula: C2H6O CLOGP: -0.24 LIPINSKI: 0 HAC: 1 HDO: 1 TPSA: 20.23 ALOGS: 1.10 ROTB: 0

Drug dosage:

None

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	1	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	2.50 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	2170.63 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability)	80 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

Date	Agency	Company	Orphan
Jan. 17, 1946	FDA	B BRAUN

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Completed suicide	8675.59	16.77	3516	47566	142157	63295783
Toxicity to various agents	4675.07	16.77	2727	48355	244523	63193417
Drug abuse	3176.47	16.77	1416	49666	71102	63366838
Cardio-respiratory arrest	1721.55	16.77	877	50205	59082	63378858
Intentional overdose	1292.43	16.77	781	50301	73371	63364569
Respiratory arrest	1070.15	16.77	523	50559	32122	63405818
Overdose	951.75	16.77	767	50315	114311	63323629
Cardiac arrest	790.69	16.77	629	50453	91916	63346024
Poisoning	786.75	16.77	325	50757	13375	63424565
Suicide attempt	740.39	16.77	512	50570	60406	63377534
Intentional product misuse	640.99	16.77	469	50613	60448	63377492
Alcohol interaction	517.57	16.77	153	50929	2256	63435684
Death	470.02	16.77	970	50112	373411	63064529
Drug hypersensitivity	423.00	16.77	833	50249	309854	63128086
Alcohol poisoning	408.42	16.77	121	50961	1798	63436142
Alcohol use	394.58	16.77	120	50962	1959	63435981
Suspected suicide	327.51	16.77	141	50941	6427	63431513
Exposure via ingestion	315.97	16.77	110	50972	2799	63435141
Alcohol abuse	236.36	16.77	82	51000	2064	63435876
Exposure to toxic agent	196.36	16.77	94	50988	5493	63432447
Coma	195.76	16.77	250	50832	64114	63373826
Diarrhoea	195.00	16.77	174	50908	715192	62722748
Poisoning deliberate	171.67	16.77	109	50973	11109	63426831
Irritable bowel syndrome	153.78	16.77	254	50828	82158	63355782
Blood alcohol increased	147.02	16.77	43	51039	609	63437331
Pneumonia	142.02	16.77	97	50985	456670	62981270
Nausea	137.70	16.77	303	50779	854168	62583772
Helicobacter infection	133.22	16.77	255	50827	92530	63345410
Gastrointestinal toxicity	130.52	16.77	80	51002	7661	63430279
Muscle injury	125.40	16.77	204	50878	65141	63372799
Headache	125.31	16.77	198	50884	633043	62804897
Fatigue	123.39	16.77	340	50742	887688	62550252
Folliculitis	122.23	16.77	210	50872	70107	63367833
Anaemia	118.53	16.77	44	51038	293386	63144554
Mydriasis	116.47	16.77	88	50994	11868	63426072
Asthenia	114.52	16.77	85	50997	383519	63054421
Ill-defined disorder	114.06	16.77	222	50860	81533	63356407
Pulmonary toxicity	113.54	16.77	79	51003	9376	63428564
Product dose omission issue	111.27	16.77	26	51056	234287	63203653
Cough	108.38	16.77	50	51032	292693	63145247
Somnolence	108.29	16.77	353	50729	178332	63259608
Urinary tract infection	106.36	16.77	40	51042	264644	63173296
Methaemoglobinaemia	104.92	16.77	47	51035	2356	63435584
Neutropenia	99.42	16.77	12	51070	174993	63262947
Substance abuse	94.90	16.77	55	51027	4752	63433188
Drug ineffective	93.50	16.77	479	50603	1044286	62393654
Duodenal ulcer perforation	92.78	16.77	212	50870	86997	63350943
Alcoholism	90.52	16.77	39	51043	1779	63436161
Medication error	89.34	16.77	155	50927	52129	63385811
Blister	87.37	16.77	266	50816	129548	63308392
Malaise	83.11	16.77	129	50953	415825	63022115
Agitation	81.78	16.77	161	50921	59596	63378344
Fall	80.95	16.77	119	50963	392215	63045725
Back pain	80.75	16.77	57	51025	264088	63173852
Off label use	79.41	16.77	278	50804	674184	62763756
Disease progression	78.94	16.77	5	51077	122753	63315187
Constipation	76.37	16.77	43	51039	224900	63213040
Intentional self-injury	75.26	16.77	98	50984	25589	63412351
Pericarditis	75.25	16.77	255	50827	131324	63306616
Impaired healing	74.57	16.77	216	50866	102326	63335614
Drug dependence	69.54	16.77	92	50990	24391	63413549
Dyspnoea	69.13	16.77	286	50796	661027	62776913
Hepatotoxicity	67.48	16.77	113	50969	36928	63401012
Thrombocytopenia	67.45	16.77	19	51063	151138	63286802
White blood cell count decreased	66.87	16.77	15	51067	139089	63298851
Pain	65.76	16.77	340	50742	740288	62697652
Dizziness	65.24	16.77	157	50925	429768	63008172
Sepsis	65.15	16.77	21	51061	153102	63284838
Febrile neutropenia	65.14	16.77	9	51073	118440	63319500
Postmortem blood drug level abnormal	65.10	16.77	20	51062	338	63437602
Victim of sexual abuse	63.41	16.77	23	51059	661	63437279
Contusion	62.71	16.77	263	50819	149781	63288159
Drug abuser	61.87	16.77	35	51047	2888	63435052
Cerebrovascular accident	59.89	16.77	8	51074	108016	63329924
Cardiac failure congestive	58.73	16.77	4	51078	92429	63345511
Liver injury	57.69	16.77	141	50941	60379	63377561
Sleep disorder due to general medical condition, insomnia type	55.57	16.77	127	50955	52090	63385850
Bronchitis	55.19	16.77	16	51066	124919	63313021
Haemoglobin decreased	55.11	16.77	24	51058	145461	63292479
Blood pressure increased	54.96	16.77	31	51051	162031	63275909
Dehydration	54.82	16.77	36	51046	173318	63264622
COVID-19	54.75	16.77	12	51070	113091	63324849
Pancytopenia	54.17	16.77	7	51075	96926	63341014
Accidental death	53.92	16.77	28	51054	1948	63435992
Decreased appetite	53.84	16.77	74	51008	250978	63186962
Drug use disorder	53.74	16.77	39	51043	4945	63432995
Chemical submission	52.32	16.77	16	51066	266	63437674
Weight decreased	52.25	16.77	89	50993	276709	63161231
Loss of consciousness	51.66	16.77	210	50872	117911	63320029
Platelet count decreased	51.05	16.77	15	51067	116107	63321833
Therapy non-responder	50.53	16.77	155	50927	75746	63362194
Blood ethanol increased	50.20	16.77	13	51069	113	63437827
Injection site pain	49.82	16.77	21	51061	129779	63308161
Victim of chemical submission	49.73	16.77	18	51064	514	63437426
Joint injury	49.63	16.77	87	50995	29485	63408455
Neuropathy peripheral	49.40	16.77	15	51067	113652	63324288
Malignant neoplasm progression	48.20	16.77	5	51077	82116	63355824
Swollen joint count increased	47.94	16.77	96	50986	35958	63401982
C-reactive protein abnormal	47.82	16.77	111	50971	45985	63391955
Lower respiratory tract infection	47.75	16.77	222	50860	132085	63305855
Acute kidney injury	47.63	16.77	87	50995	263328	63174612
Hepatic failure	47.48	16.77	95	50987	35561	63402379
Aggression	47.29	16.77	75	51007	23423	63414517
Arthropathy	46.61	16.77	336	50746	234456	63203484
Gastrooesophageal reflux disease	46.59	16.77	10	51072	95629	63342311
Myocarditis	46.28	16.77	49	51033	10276	63427664
Pulmonary embolism	46.21	16.77	18	51064	116666	63321274
Unresponsive to stimuli	46.12	16.77	91	50991	33725	63404215
Iodine allergy	45.87	16.77	19	51063	785	63437155
Anti-cyclic citrullinated peptide antibody positive	45.68	16.77	200	50882	116012	63321928
Psoriasis	44.65	16.77	8	51074	86949	63350991
Leukopenia	44.62	16.77	5	51077	77285	63360655
Influenza	44.35	16.77	16	51066	108706	63329234
Injection site erythema	44.15	16.77	7	51075	83167	63354773
Road traffic accident	43.38	16.77	93	50989	36539	63401401
Gastrointestinal disorder	42.88	16.77	214	50868	131025	63306915
Neoplasm malignant	42.72	16.77	82	51000	29779	63408161
Rheumatic fever	41.68	16.77	101	50981	43010	63394930
Erythema	41.63	16.77	48	51034	175703	63262237
Electrocardiogram QRS complex prolonged	41.49	16.77	36	51046	5902	63432038
Herpes zoster	41.46	16.77	8	51074	82454	63355486
Discomfort	40.71	16.77	252	50830	167122	63270818
Depressed level of consciousness	40.59	16.77	126	50956	61952	63375988
Metabolic acidosis	39.79	16.77	102	50980	44967	63392973
Pyrexia	39.39	16.77	220	50862	470258	62967682
Asphyxia	38.28	16.77	35	51047	6146	63431794
Tachycardia	38.12	16.77	192	50890	117964	63319976
Arthritis	38.12	16.77	23	51059	115898	63322042
Rheumatoid factor positive	37.64	16.77	151	50931	84255	63353685
Hepatic enzyme increased	37.55	16.77	285	50797	202043	63235897
Somnambulism	37.51	16.77	33	51049	5510	63432430
Infection	37.18	16.77	313	50769	228860	63209080
Septic shock	36.77	16.77	5	51077	66624	63371316
Congestive hepatopathy	36.30	16.77	25	51057	2917	63435023
Injection site reaction	35.85	16.77	3	51079	58521	63379419
Abdominal pain	35.71	16.77	119	50963	293337	63144603
Hyponatraemia	35.69	16.77	23	51059	111877	63326063
Seizure	35.64	16.77	205	50877	132429	63305511
Substance use disorder	35.26	16.77	11	51071	196	63437744
Epistaxis	34.62	16.77	8	51074	72717	63365223
Drug withdrawal syndrome	34.48	16.77	71	51011	27123	63410817
Neck pain	34.27	16.77	7	51075	69311	63368629
Palpitations	33.55	16.77	25	51057	112745	63325195
Vision blurred	33.50	16.77	16	51066	91908	63346032
Pain in extremity	33.49	16.77	145	50937	331341	63106599
Electrocardiogram QT prolonged	32.80	16.77	114	50968	59416	63378524
C-reactive protein increased	32.26	16.77	18	51064	94689	63343251
Homicide	32.19	16.77	12	51070	373	63437567
Maternal exposure timing unspecified	30.65	16.77	33	51049	7054	63430886
Suicidal ideation	30.54	16.77	115	50967	62306	63375634
Intentional product use issue	30.11	16.77	191	50891	127701	63310239
Housebound	29.91	16.77	10	51072	224	63437716
Confusional state	29.85	16.77	306	50776	236074	63201866
Hip arthroplasty	29.58	16.77	95	50987	47551	63390389
Sleep disorder	29.51	16.77	137	50945	81429	63356511
Drug screen positive	29.48	16.77	24	51058	3605	63434335
Oropharyngeal pain	29.35	16.77	20	51062	94467	63343473
Respiratory depression	29.30	16.77	45	51037	13670	63424270
Myocardial infarction	28.63	16.77	23	51059	99870	63338070
Renal impairment	28.39	16.77	18	51064	88337	63349603
Cystitis	28.36	16.77	5	51077	54986	63382954
Chest discomfort	28.30	16.77	28	51054	109941	63327999
Gastrointestinal haemorrhage	28.27	16.77	15	51067	81161	63356779
Rash	28.19	16.77	302	50780	560569	62877371
Sinus tachycardia	28.03	16.77	61	51021	24207	63413733
Rhinorrhoea	27.86	16.77	9	51073	65568	63372372
Electrocardiogram ST segment elevation	27.83	16.77	24	51058	3903	63434037
Protein C increased	27.50	16.77	8	51074	111	63437829
Abdominal distension	27.35	16.77	18	51064	86597	63351343
Muscular weakness	27.29	16.77	35	51047	122318	63315622
Mucosal inflammation	27.17	16.77	3	51079	46925	63391015
Hepatic encephalopathy	26.94	16.77	39	51043	11243	63426697
Productive cough	26.29	16.77	9	51073	63199	63374741
Accidental overdose	26.25	16.77	58	51024	23251	63414689
Nasal congestion	26.20	16.77	10	51072	65650	63372290
Inappropriate schedule of product administration	26.15	16.77	27	51055	103938	63334002
Disinhibition	25.50	16.77	13	51069	870	63437070
Brain oedema	25.44	16.77	43	51039	14152	63423788
Product administration interrupted	25.40	16.77	25	51057	4811	63433129
Influenza like illness	25.33	16.77	11	51071	66813	63371127
Injection site swelling	25.25	16.77	4	51078	47568	63390372
Environmental exposure	24.85	16.77	7	51075	86	63437854
Balance disorder	24.74	16.77	19	51063	84403	63353537
Knee arthroplasty	24.18	16.77	97	50985	54109	63383831
Chest pain	23.97	16.77	91	50991	215868	63222072
Hyperkalaemia	23.82	16.77	7	51075	54196	63383744
Syncope	23.76	16.77	36	51046	117349	63320591
Aspiration	23.74	16.77	36	51046	10815	63427125
Neutrophil count decreased	23.51	16.77	8	51074	56398	63381542
Haematochezia	23.37	16.77	7	51075	53537	63384403
Cellulitis	23.32	16.77	19	51063	81939	63356001
Substance dependence	23.26	16.77	8	51074	196	63437744
Deep vein thrombosis	23.14	16.77	20	51062	83780	63354160
Incorrect route of product administration	23.07	16.77	61	51021	27391	63410549
Loss of personal independence in daily activities	22.56	16.77	27	51055	97263	63340677
Myalgia	22.56	16.77	53	51029	146476	63291464
Thrombosis	22.50	16.77	12	51070	64743	63373197
Bone pain	22.34	16.77	8	51074	54633	63383307
Interstitial lung disease	22.21	16.77	11	51071	61897	63376043
Dry skin	22.15	16.77	9	51073	56878	63381062
Muscle spasms	22.08	16.77	59	51023	156091	63281849
Toxicologic test abnormal	21.95	16.77	11	51071	710	63437230
Feeling abnormal	21.80	16.77	55	51027	148337	63289603
Breast cancer	21.72	16.77	6	51076	48377	63389563
Induced abortion failed	21.61	16.77	8	51074	244	63437696
Haematocrit decreased	21.59	16.77	3	51079	39337	63398603
Diabetes mellitus	21.45	16.77	9	51073	55801	63382139
Stomatitis	21.17	16.77	187	50895	138538	63299402
Upper respiratory tract infection	20.98	16.77	21	51061	82026	63355914
Rash pruritic	20.89	16.77	11	51071	59788	63378152
Chills	20.86	16.77	37	51045	113341	63324599
Red blood cell sedimentation rate increased	20.61	16.77	5	51077	43977	63393963
Alcohol withdrawal syndrome	20.53	16.77	11	51071	816	63437124
Gait disturbance	20.44	16.77	77	51005	183101	63254839
Dysphagia	20.10	16.77	25	51057	88560	63349380
Congenital umbilical hernia	19.92	16.77	8	51074	305	63437635
Hand deformity	19.90	16.77	206	50876	159251	63278689
Amnesia	19.83	16.77	93	50989	55492	63382448
Joint stiffness	19.54	16.77	76	51006	41793	63396147
Diverticulitis	19.54	16.77	4	51078	39553	63398387
Dysphonia	19.42	16.77	7	51075	47607	63390333
Fluid retention	19.39	16.77	12	51070	59674	63378266
Sopor	19.39	16.77	50	51032	22114	63415826
Lupus vulgaris	19.34	16.77	24	51058	5970	63431970
Visceral congestion	19.28	16.77	8	51074	332	63437608
Oedema peripheral	19.05	16.77	83	50999	189428	63248512
Alcoholic	18.96	16.77	5	51077	47	63437893
Acute hepatic failure	18.86	16.77	44	51038	18283	63419657
Blood pH decreased	18.72	16.77	16	51066	2571	63435369
Brain death	18.61	16.77	18	51064	3392	63434548
Chronic obstructive pulmonary disease	18.51	16.77	14	51068	62672	63375268
Deep vein thrombosis postoperative	18.49	16.77	33	51049	11336	63426604
Cognitive disorder	18.45	16.77	11	51071	55804	63382136
Miosis	18.41	16.77	26	51056	7327	63430613
Blood methanol increased	18.38	16.77	3	51079	0	63437940
C-reactive protein	18.14	16.77	21	51061	4861	63433079
Areflexia	18.04	16.77	17	51065	3101	63434839
Gastric disorder	18.01	16.77	4	51078	37365	63400575
Lip dry	18.00	16.77	39	51043	15431	63422509
Osteoporosis	17.99	16.77	12	51070	57326	63380614
Postmortem blood drug level	17.84	16.77	6	51076	137	63437803
Pulmonary hypertension	17.83	16.77	4	51078	37119	63400821
Atrial fibrillation	17.31	16.77	43	51039	116593	63321347
Dyspnoea exertional	17.13	16.77	14	51068	60288	63377652
Cardio-respiratory distress	17.11	16.77	6	51076	156	63437784
Cholelithiasis	17.02	16.77	7	51075	43918	63394022
Facet joint syndrome	16.95	16.77	33	51049	12105	63425835
Vertigo	16.89	16.77	14	51068	59873	63378067

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug abuse	8933.59	20.73	3427	31989	95669	34825846
Completed suicide	6867.27	20.73	2834	32582	95334	34826181
Toxicity to various agents	5743.71	20.73	3124	32292	197238	34724277
Cardio-respiratory arrest	1595.84	20.73	875	34541	54398	34867117
Intentional product misuse	1184.16	20.73	674	34742	44937	34876578
Intentional overdose	1121.85	20.73	641	34775	43033	34878482
Poisoning	966.27	20.73	389	35027	11837	34909678
Overdose	947.66	20.73	763	34653	90296	34831219
Respiratory arrest	942.49	20.73	492	34924	27551	34893964
Alcohol abuse	663.89	20.73	229	35187	4461	34917054
Cardiac arrest	578.96	20.73	593	34823	95566	34825949
Suicide attempt	566.23	20.73	400	35016	38716	34882799
Alcohol interaction	534.65	20.73	173	35243	2740	34918775
Alcohol poisoning	526.25	20.73	180	35236	3413	34918102
Exposure via ingestion	472.55	20.73	147	35269	2034	34919481
Death	448.33	20.73	1133	34283	396916	34524599
Drug dependence	434.51	20.73	283	35133	23934	34897581
Substance abuse	410.34	20.73	185	35231	7456	34914059
Suspected suicide	343.75	20.73	142	35274	4606	34916909
Coma	330.68	20.73	312	35104	45366	34876149
Alcohol use	317.22	20.73	121	35295	3167	34918348
Asphyxia	315.47	20.73	149	35267	6686	34914829
Poisoning deliberate	290.11	20.73	147	35269	7697	34913818
Respiratory depression	227.51	20.73	163	35253	16082	34905433
Diarrhoea	217.94	20.73	63	35353	389849	34531666
Blood alcohol increased	210.36	20.73	63	35353	760	34920755
Pneumonia	200.01	20.73	60	35356	362567	34558948
Aggression	194.45	20.73	218	35198	38746	34882769
Drug ineffective	192.19	20.73	113	35303	456638	34464877
Exposure to toxic agent	187.84	20.73	86	35330	3589	34917926
Pyrexia	174.87	20.73	60	35356	332953	34588562
Anaemia	170.17	20.73	19	35397	233316	34688199
Fatigue	155.26	20.73	92	35324	370561	34550954
Dyspnoea	154.38	20.73	96	35320	376686	34544829
Accidental death	152.90	20.73	66	35350	2390	34919125
Off label use	150.82	20.73	123	35293	419401	34502114
Neutropenia	121.50	20.73	10	35406	156768	34764747
Rash	120.48	20.73	38	35378	222714	34698801
Accidental overdose	111.38	20.73	119	35297	20021	34901494
Miosis	107.41	20.73	84	35332	9451	34912064
Incorrect route of product administration	106.49	20.73	101	35315	14744	34906771
Drug use disorder	105.85	20.73	61	35355	4130	34917385
Nausea	102.89	20.73	116	35300	339792	34581723
Substance use disorder	102.34	20.73	36	35380	743	34920772
Intentional self-injury	101.28	20.73	95	35321	13676	34907839
Drug withdrawal syndrome	97.21	20.73	110	35306	19724	34901791
Febrile neutropenia	95.10	20.73	13	35403	136836	34784679
Cough	93.84	20.73	19	35397	150121	34771394
Depressed level of consciousness	93.65	20.73	161	35255	42680	34878835
Agitation	92.16	20.73	189	35227	57210	34864305
Sepsis	90.74	20.73	28	35388	166533	34754982
Arthralgia	90.12	20.73	30	35386	170011	34751504
Alcohol withdrawal syndrome	89.45	20.73	39	35377	1447	34920068
Prescription drug used without a prescription	87.38	20.73	43	35373	2111	34919404
Drug abuser	85.34	20.73	52	35364	3902	34917613
Alcoholism	85.29	20.73	47	35369	2918	34918597
Asthenia	85.27	20.73	74	35342	245177	34676338
Drug screen positive	82.92	20.73	51	35365	3892	34917623
Methaemoglobinaemia	82.21	20.73	49	35367	3532	34917983
Suicidal ideation	79.52	20.73	145	35271	40243	34881272
Mydriasis	77.74	20.73	62	35354	7175	34914340
Pain	77.07	20.73	57	35359	204618	34716897
Condition aggravated	77.04	20.73	50	35366	192146	34729369
Pain in extremity	75.01	20.73	18	35398	126495	34795020
Withdrawal syndrome	71.35	20.73	75	35341	12380	34909135
Product dose omission issue	71.03	20.73	17	35399	119694	34801821
Pruritus	70.21	20.73	28	35388	141953	34779562
Haemoglobin decreased	70.01	20.73	18	35398	120754	34800761
Malignant neoplasm progression	69.90	20.73	5	35411	88041	34833474
Pancytopenia	68.60	20.73	8	35408	95149	34826366
Decreased appetite	68.44	20.73	42	35374	166350	34755165
Intentional product use issue	68.20	20.73	172	35244	59644	34861871
Medication error	67.96	20.73	105	35311	25460	34896055
Platelet count decreased	67.22	20.73	19	35397	119698	34801817
Back pain	67.15	20.73	20	35396	121769	34799746
White blood cell count decreased	66.44	20.73	9	35407	95436	34826079
Unresponsive to stimuli	66.08	20.73	108	35308	27461	34894054
Dizziness	63.37	20.73	77	35339	218444	34703071
Thrombocytopenia	60.76	20.73	42	35374	156205	34765310
Environmental exposure	60.39	20.73	19	35397	273	34921242
Oedema peripheral	60.26	20.73	23	35393	119789	34801726
Alcohol intolerance	60.08	20.73	21	35395	425	34921090
Infection	57.83	20.73	11	35405	90904	34830611
Road traffic accident	57	20.73	79	35337	17371	34904144
Pulmonary oedema	56.62	20.73	139	35277	47390	34874125
Blood ethanol increased	53.91	20.73	20	35396	483	34921032
Sopor	52.27	20.73	63	35353	12073	34909442
Renal impairment	51.22	20.73	16	35400	94497	34827018
Loss of consciousness	51.21	20.73	192	35224	82475	34839040
Cardiac failure congestive	51.03	20.73	11	35405	83259	34838256
General physical health deterioration	50.50	20.73	34	35382	128235	34793280
Weight decreased	50.15	20.73	63	35353	176238	34745277
Atrial fibrillation	50.15	20.73	31	35385	122362	34799153
COVID-19	50.14	20.73	9	35407	77541	34843974
Nasopharyngitis	50.13	20.73	6	35410	69962	34851553
Metabolic acidosis	49.14	20.73	125	35291	43555	34877960
Pulmonary embolism	48.98	20.73	15	35401	89731	34831784
Tachycardia	48.51	20.73	192	35224	84580	34836935
Cerebrovascular accident	48.45	20.73	13	35403	84798	34836717
Drug intolerance	48.39	20.73	3	35413	59567	34861948
Neuropathy peripheral	47.12	20.73	13	35403	83250	34838265
Abdominal pain	47.02	20.73	58	35358	163560	34757955
Cardiac failure	46.74	20.73	17	35399	91231	34830284
Constipation	46.71	20.73	42	35374	136940	34784575
Chest pain	45.50	20.73	37	35379	126725	34794790
Myocardial infarction	45.16	20.73	34	35382	121051	34800464
Peripheral swelling	45.13	20.73	11	35405	76530	34844985
Ex-drug abuser	44.65	20.73	13	35403	141	34921374
Physical assault	43.90	20.73	22	35394	1123	34920392
Pleural effusion	43.83	20.73	14	35402	81532	34839983
Headache	43.49	20.73	86	35330	200549	34720966
Amnesia	43.22	20.73	88	35328	26475	34895040
Malaise	42.60	20.73	77	35339	185748	34735767
Urinary tract infection	42.50	20.73	16	35400	84065	34837450
Infusion related reaction	42.13	20.73	3	35413	53054	34868461
Homicide	41.67	20.73	20	35396	929	34920586
Shock	41.62	20.73	82	35334	24097	34897418
Somnolence	40.82	20.73	221	35195	110895	34810620
Dehydration	40.66	20.73	43	35373	129926	34791589
Neutrophil count decreased	40.26	20.73	3	35413	51101	34870414
Muscular weakness	40.10	20.73	12	35404	72885	34848630
Self-medication	39.84	20.73	28	35388	2675	34918840
Drug interaction	39.81	20.73	376	35040	225570	34695945
Therapeutic product effect incomplete	39.73	20.73	3	35413	50538	34870977
Septic shock	39.20	20.73	12	35404	71822	34849693
Weight increased	38.89	20.73	23	35393	93010	34828505
Urticaria	38.71	20.73	8	35408	62369	34859146
Bradypnoea	38.69	20.73	28	35388	2801	34918714
Joint swelling	38.60	20.73	7	35409	59883	34861632
Acute kidney injury	38.29	20.73	169	35247	304819	34616696
Deep vein thrombosis	37.26	20.73	10	35406	65238	34856277
Chills	36.85	20.73	18	35398	81025	34840490
Myalgia	36.29	20.73	20	35396	84090	34837425
Treatment failure	36.06	20.73	3	35413	46694	34874821
Suicidal behaviour	35.71	20.73	21	35395	1476	34920039
Erythema	35.64	20.73	23	35393	88757	34832758
Chronic obstructive pulmonary disease	35.52	20.73	4	35412	48914	34872601
Dysphagia	34.80	20.73	10	35406	62371	34859144
Cluster headache	34.54	20.73	15	35401	551	34920964
Thrombosis	34.53	20.73	5	35411	50453	34871062
Brain oedema	34.27	20.73	55	35361	13766	34907749
Abnormal behaviour	34.05	20.73	77	35339	24892	34896623
Leukopenia	33.41	20.73	11	35405	62845	34858670
Haematochezia	33.30	20.73	4	35412	46530	34874985
Gun shot wound	32.77	20.73	18	35398	1110	34920405
Renal failure	31.82	20.73	52	35364	130505	34791010
Toxicologic test abnormal	31.55	20.73	14	35402	542	34920973
Impaired driving ability	31.40	20.73	24	35392	2609	34918906
Opiates positive	30.96	20.73	14	35402	567	34920948
Hepatic fibrosis	30.49	20.73	30	35386	4577	34916938
Dyspnoea exertional	30.29	20.73	4	35412	43275	34878240
Stomatitis	29.59	20.73	4	35412	42510	34879005
Influenza	29.54	20.73	7	35409	49659	34871856
Behavioural addiction	29.44	20.73	8	35408	66	34921449
Prostate cancer	29.41	20.73	3	35413	39646	34881869
Blood ethanol	29.29	20.73	9	35407	119	34921396
Electrocardiogram QRS complex prolonged	28.97	20.73	30	35386	4864	34916651
Dysarthria	28.74	20.73	89	35327	34693	34886822
Sinusitis	28.57	20.73	4	35412	41398	34880117
Exposure via inhalation	28.44	20.73	7	35409	37	34921478
Acute hepatic failure	28.28	20.73	51	35365	14023	34907492
Foetal alcohol syndrome	28.19	20.73	9	35407	136	34921379
Pulmonary congestion	27.81	20.73	50	35366	13715	34907800
Musculoskeletal stiffness	26.94	20.73	7	35409	46673	34874842
Hepatitis C virus test positive	26.87	20.73	11	35405	348	34921167
Hospitalisation	26.85	20.73	12	35404	56890	34864625
Abdominal distension	26.57	20.73	13	35403	58479	34863036
Electrocardiogram repolarisation abnormality	26.39	20.73	15	35401	989	34920526
Acidosis	26.38	20.73	43	35373	10902	34910613
Hypersensitivity	25.62	20.73	15	35401	61020	34860495
Cellulitis	25.24	20.73	11	35405	52940	34868575
C-reactive protein increased	24.61	20.73	12	35404	54086	34867429
Haematuria	24.51	20.73	10	35406	50056	34871459
Dyspepsia	24.31	20.73	4	35412	36728	34884787
Chronic kidney disease	24.13	20.73	6	35410	41204	34880311
Accidental poisoning	24.04	20.73	13	35403	777	34920738
Pneumonitis	24.03	20.73	3	35413	33875	34887640
Myocardial fibrosis	23.94	20.73	15	35401	1182	34920333
Inappropriate schedule of product administration	23.85	20.73	17	35399	62279	34859236
Chest discomfort	23.46	20.73	13	35403	54517	34866998
Bronchitis	22.90	20.73	7	35409	41956	34879559
Hypertension	22.78	20.73	67	35349	136376	34785139
Pupil fixed	22.77	20.73	17	35399	1784	34919731
Accidental exposure to product	22.73	20.73	44	35372	12758	34908757
Therapeutic product effect decreased	22.51	20.73	4	35412	34739	34886776
Wheezing	22.43	20.73	7	35409	41395	34880120
Product use in unapproved indication	22.42	20.73	54	35362	117445	34804070
Legal problem	22.35	20.73	8	35408	174	34921341
Abdominal discomfort	22.03	20.73	17	35399	59818	34861697
Sensorimotor disorder	21.51	20.73	10	35406	432	34921083
Swelling	21.50	20.73	8	35408	42358	34879157
Dextrocardia	21.38	20.73	7	35409	115	34921400
Alcoholic liver disease	21.32	20.73	11	35405	597	34920918
Productive cough	21.20	20.73	6	35410	37807	34883708

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Completed suicide	15565.82	16.70	6414	66636	239353	79431985
Drug abuse	11793.44	16.70	4694	68356	157997	79513341
Toxicity to various agents	10213.10	16.70	5694	67356	415846	79255492
Cardio-respiratory arrest	3396.26	16.70	1753	71297	106757	79564581
Intentional overdose	2138.52	16.70	1284	71766	104676	79566662
Respiratory arrest	2099.76	16.70	1033	72017	56517	79614821
Intentional product misuse	1805.87	16.70	1109	71941	94056	79577282
Overdose	1754.21	16.70	1406	71644	182800	79488538
Poisoning	1733.18	16.70	706	72344	24566	79646772
Cardiac arrest	1441.84	16.70	1220	71830	170876	79500462
Death	1259.84	16.70	2020	71030	564494	79106844
Alcohol interaction	900.38	16.70	284	72766	4590	79666748
Suicide attempt	873.51	16.70	673	72377	82259	79589079
Alcohol poisoning	788.18	16.70	256	72794	4565	79666773
Alcohol use	767.40	16.70	251	72799	4580	79666758
Exposure via ingestion	766.42	16.70	255	72795	4919	79666419
Alcohol abuse	706.40	16.70	242	72808	5121	79666217
Suspected suicide	618.66	16.70	264	72786	10312	79661026
Coma	481.69	16.70	525	72525	100124	79571214
Drug dependence	448.94	16.70	340	72710	40429	79630909
Poisoning deliberate	441.43	16.70	252	72798	18576	79652762
Substance abuse	413.29	16.70	199	72851	10327	79661011
Exposure to toxic agent	374.35	16.70	178	72872	8980	79662358
Diarrhoea	368.46	16.70	174	72876	880315	78791023
Blood alcohol increased	305.18	16.70	91	72959	1204	79670134
Pneumonia	289.11	16.70	122	72928	660124	79011214
Asphyxia	288.56	16.70	162	72888	11558	79659780
Drug ineffective	277.98	16.70	351	72699	1080562	78590776
Fatigue	268.11	16.70	275	72775	929452	78741886
Drug hypersensitivity	268.01	16.70	737	72313	298179	79373159
Anaemia	253.62	16.70	50	73000	444965	79226373
Dyspnoea	239.66	16.70	260	72790	856765	78814573
Nausea	237.44	16.70	319	72731	956877	78714461
Off label use	230.42	16.70	297	72753	906918	78764420
Accidental death	205.22	16.70	93	72957	4198	79667140
Respiratory depression	196.63	16.70	179	72871	27451	79643887
Neutropenia	195.00	16.70	19	73031	287691	79383647
Drug abuser	186.81	16.70	97	72953	5916	79665422
Headache	186.21	16.70	195	72855	653577	79017761
Methaemoglobinaemia	182.33	16.70	93	72957	5464	79665874
Cough	180.20	16.70	56	72994	366733	79304605
Aggression	175.77	16.70	225	72825	50733	79620605
Asthenia	174.09	16.70	129	72921	511560	79159778
Mydriasis	172.08	16.70	137	72913	17506	79653832
Pyrexia	164.07	16.70	230	72820	678479	78992859
Agitation	162.93	16.70	312	72738	99403	79571935
Medication error	158.18	16.70	250	72800	68392	79602946
Intentional self-injury	156.44	16.70	170	72880	32249	79639089
Drug use disorder	148.95	16.70	95	72955	8556	79662782
Disease progression	146.47	16.70	5	73045	184357	79486981
Pain	144.21	16.70	266	72784	703536	78967802
Urinary tract infection	143.88	16.70	37	73013	274475	79396863
Febrile neutropenia	142.34	16.70	21	73029	230978	79440360
Product dose omission issue	132.36	16.70	32	73018	247505	79423833
Substance use disorder	130.05	16.70	44	73006	894	79670444
Sepsis	128.96	16.70	43	73007	269385	79401953
Miosis	125.67	16.70	109	72941	15680	79655658
Dizziness	123.52	16.70	182	72868	526259	79145079
Incorrect route of product administration	123.24	16.70	156	72894	34773	79636565
Back pain	122.30	16.70	63	72987	304117	79367221
Depressed level of consciousness	122.05	16.70	272	72778	96380	79574958
Alcoholism	121.25	16.70	62	72988	3661	79667677
Accidental overdose	119.88	16.70	164	72886	39417	79631921
Malaise	118.21	16.70	166	72884	489703	79181635
Pain in extremity	114.95	16.70	99	72951	364439	79306899
Blood ethanol increased	114.06	16.70	37	73013	656	79670682
Arthralgia	113.59	16.70	220	72830	571583	79099755
Pancytopenia	112.09	16.70	11	73039	165734	79505604
White blood cell count decreased	111.73	16.70	19	73031	188269	79483069
Condition aggravated	111.07	16.70	180	72870	500944	79170394
Somnolence	110.76	16.70	473	72577	238508	79432830
Constipation	110.29	16.70	61	72989	282989	79388349
Decreased appetite	107.94	16.70	93	72957	342325	79329013
Haemoglobin decreased	107.06	16.70	35	73015	222084	79449254
Rash	106.01	16.70	233	72817	578125	79093213
Thrombocytopenia	103.58	16.70	57	72993	265202	79406136
Platelet count decreased	98.64	16.70	28	73022	194636	79476702
Unresponsive to stimuli	97.85	16.70	180	72870	55608	79615730
Malignant neoplasm progression	97.52	16.70	7	73043	135983	79535355
Weight decreased	97.49	16.70	109	72941	355089	79316249
Drug screen positive	93.16	16.70	62	72988	6001	79665337
Cerebrovascular accident	91.40	16.70	16	73034	155276	79516062
Fall	89.67	16.70	196	72854	487433	79183905
COVID-19	89.06	16.70	18	73032	157656	79513682
Cardiac failure congestive	87.56	16.70	13	73037	142389	79528949
Metabolic acidosis	87.55	16.70	217	72833	82312	79589026
Environmental exposure	85.06	16.70	26	73024	376	79670962
Dehydration	84.98	16.70	62	72988	248125	79423213
Electrocardiogram QRS complex prolonged	84.63	16.70	74	72976	10759	79660579
Abdominal pain	82.49	16.70	144	72906	389425	79281913
Alcohol withdrawal syndrome	81.90	16.70	39	73011	1972	79669366
Acute kidney injury	81.24	16.70	227	72823	519177	79152161
Pulmonary embolism	81.04	16.70	28	73022	171626	79499712
Loss of consciousness	79.76	16.70	335	72715	167608	79503730
Tachycardia	77.08	16.70	345	72705	177423	79493915
Prescription drug used without a prescription	75.69	16.70	47	73003	4038	79667300
Postmortem blood drug level abnormal	72.64	16.70	26	73024	628	79670710
Erythema	72.34	16.70	59	72991	223231	79448107
Bronchitis	71.56	16.70	16	73034	130628	79540710
Road traffic accident	70.50	16.70	136	72914	43528	79627810
Interstitial lung disease	69.87	16.70	10	73040	112590	79558748
Leukopenia	68.57	16.70	12	73038	116501	79554837
Drug withdrawal syndrome	68.57	16.70	118	72932	34600	79636738
Blood pressure increased	68.28	16.70	56	72994	211304	79460034
Septic shock	67.34	16.70	15	73035	122786	79548552
Neuropathy peripheral	66.78	16.70	23	73027	141282	79530056
Withdrawal syndrome	63.48	16.70	99	72951	26755	79644583
Herpes zoster	63.39	16.70	6	73044	93077	79578261
Influenza	63.17	16.70	20	73030	129586	79541752
Pulmonary oedema	63.01	16.70	201	72849	88053	79583285
Renal impairment	62.88	16.70	33	73017	157750	79513588
Chest pain	61.88	16.70	102	72948	282202	79389136
Irritable bowel syndrome	61.15	16.70	159	72891	62082	79609256
Homicide	60.84	16.70	27	73023	1159	79670179
Suicidal ideation	60.19	16.70	180	72870	76160	79595178
Myocardial infarction	59.20	16.70	49	73001	184080	79487258
Oedema peripheral	58.28	16.70	88	72962	252200	79419138
Intentional product use issue	57.71	16.70	284	72766	151828	79519510
Helicobacter infection	57.48	16.70	167	72883	69537	79601801
Neutrophil count decreased	56.79	16.70	9	73041	93950	79577388
Injection site erythema	56.12	16.70	4	73046	78193	79593145
Injection site pain	55.01	16.70	25	73025	129813	79541525
Shock	54.32	16.70	122	72928	43426	79627912
Muscular weakness	53.90	16.70	41	73009	160688	79510650
Abdominal distension	52.33	16.70	22	73028	119628	79551710
Chemical submission	51.46	16.70	17	73033	320	79671018
C-reactive protein increased	51.39	16.70	27	73023	129000	79542338
Cellulitis	51.10	16.70	18	73032	109042	79562296
Pruritus	50.80	16.70	188	72862	394460	79276878
Chest discomfort	50.54	16.70	32	73018	138012	79533326
Hyponatraemia	50.48	16.70	53	72997	177795	79493543
Victim of chemical submission	50.34	16.70	19	73031	535	79670803
Inappropriate schedule of product administration	50.28	16.70	30	73020	133598	79537740
Haematochezia	49.49	16.70	10	73040	87635	79583703
Gastrooesophageal reflux disease	49.20	16.70	17	73033	104229	79567109
Chills	48.65	16.70	45	73005	160189	79511149
Toxicologic test abnormal	48.25	16.70	24	73026	1336	79670002
Oropharyngeal pain	47.99	16.70	20	73030	109333	79562005
Epistaxis	47.98	16.70	21	73029	111494	79559844
Blood ethanol	47.97	16.70	14	73036	171	79671167
Chronic obstructive pulmonary disease	47.71	16.70	10	73040	85409	79585929
Pleural effusion	47.51	16.70	38	73012	145224	79526114
Victim of sexual abuse	47.45	16.70	18	73032	514	79670824
Psoriasis	47.03	16.70	12	73038	89575	79581763
Dyspnoea exertional	47.00	16.70	11	73039	87062	79584276
Drug reaction with eosinophilia and systemic symptoms	46.94	16.70	3	73047	64241	79607097
Sinus tachycardia	46.70	16.70	104	72946	36804	79634534
Myalgia	46.60	16.70	61	72989	185580	79485758
Dysphagia	46.55	16.70	27	73023	122109	79549229
Sopor	46.33	16.70	97	72953	32913	79638425
Opiates positive	45.62	16.70	21	73029	983	79670355
Alcohol intolerance	45.40	16.70	17	73033	468	79670870
Atrial fibrillation	44.75	16.70	70	72980	197816	79473522
Pulmonary congestion	44.47	16.70	85	72965	27015	79644323
Colitis	44.35	16.70	7	73043	73300	79598038
Cardiac failure	44.11	16.70	46	73004	154796	79516542
Neck pain	43.86	16.70	8	73042	75409	79595929
Electrocardiogram QT prolonged	43.42	16.70	181	72869	90205	79581133
Deep vein thrombosis	42.95	16.70	29	73021	120890	79550448
Sleep disorder due to general medical condition, insomnia type	42.51	16.70	111	72939	43445	79627893
Brain oedema	42.39	16.70	80	72970	25183	79646155
Productive cough	42.39	16.70	14	73036	88317	79583021
Renal failure	41.83	16.70	75	72975	200893	79470445
Loss of personal independence in daily activities	41.54	16.70	21	73029	102559	79568779
Hyperkalaemia	41.22	16.70	27	73023	114371	79556967
Thrombosis	40.94	16.70	13	73037	84087	79587251
Gastrointestinal haemorrhage	40.83	16.70	45	73005	147674	79523664
Rash pruritic	40.80	16.70	8	73042	71621	79599717
Nasal congestion	40.67	16.70	10	73040	76542	79594796
Fluid retention	39.34	16.70	8	73042	69801	79601537
Acidosis	38.80	16.70	67	72983	19695	79651643
Bradypnoea	38.79	16.70	37	73013	6015	79665323
Mucosal inflammation	38.02	16.70	11	73039	75569	79595769
Somnambulism	36.71	16.70	35	73015	5686	79665652
General physical health deterioration	36.12	16.70	130	72920	275108	79396230
Liver injury	35.99	16.70	124	72926	56490	79614848
Amphetamines positive	35.75	16.70	13	73037	329	79671009
Postmortem blood drug level	35.53	16.70	13	73037	335	79671003
Arthritis	35.18	16.70	32	73018	114848	79556490
Therapeutic product effect incomplete	35.07	16.70	47	73003	141598	79529740
Joint swelling	34.86	16.70	141	72909	288505	79382833
Abdominal pain upper	34.77	16.70	98	72952	223721	79447617
Rash maculo-papular	34.74	16.70	5	73045	56073	79615265
Syncope	34.69	16.70	70	72980	179379	79491959
Haemoptysis	34.67	16.70	5	73045	55994	79615344
Seizure	34.49	16.70	293	72757	188541	79482797
Pneumonitis	34.24	16.70	7	73043	60853	79610485
Physical assault	33.61	16.70	20	73030	1591	79669747
Angina pectoris	33.51	16.70	4	73046	51728	79619610
Diabetes mellitus	33.34	16.70	15	73035	78375	79592963
Pupil fixed	33.30	16.70	27	73023	3539	79667799
Amnesia	33.25	16.70	130	72920	62927	79608411
Cataract	33.23	16.70	8	73042	62112	79609226
Angioedema	33.21	16.70	14	73036	76021	79595317
Muscle injury	33.20	16.70	109	72941	48452	79622886
Drug ineffective for unapproved indication	33.10	16.70	4	73046	51234	79620104
Product administration error	32.98	16.70	83	72967	31763	79639575
Acute hepatic failure	32.78	16.70	80	72970	30033	79641305
Hypertension	32.69	16.70	174	72876	330818	79340520
Stress	32.68	16.70	16	73034	79596	79591742
Chronic kidney disease	32.60	16.70	10	73040	66144	79605194
Feeling abnormal	32.60	16.70	60	72990	159139	79512199
Orthostatic hypotension	32.57	16.70	6	73044	56158	79615180
Haemorrhage	32.16	16.70	22	73028	91096	79580242
Cystitis	31.98	16.70	5	73045	52727	79618611
Rectal haemorrhage	31.83	16.70	15	73035	76285	79595053
Drug level increased	31.73	16.70	94	72956	39557	79631781
Product use in unapproved indication	31.70	16.70	120	72930	250239	79421099
Blood pressure fluctuation	31.59	16.70	11	73039	67134	79604204
Aspiration	31.57	16.70	62	72988	20096	79651242
Gastrointestinal toxicity	31.46	16.70	38	73012	8071	79663267
Congestive hepatopathy	31.44	16.70	29	73021	4518	79666820
Therapeutic response decreased	31.37	16.70	11	73039	66842	79604496
Upper respiratory tract infection	30.88	16.70	23	73027	91145	79580193
Substance dependence	30.85	16.70	13	73037	491	79670847
Haematocrit decreased	30.70	16.70	9	73041	61303	79610035
Vision blurred	30.67	16.70	31	73019	105867	79565471
Gait disturbance	30.67	16.70	93	72957	207413	79463925
Cardiac disorder	30.55	16.70	11	73039	65746	79605592
Dry skin	30.54	16.70	12	73038	67983	79603355
Agranulocytosis	30.40	16.70	3	73047	45027	79626311
Self-medication	30.31	16.70	30	73020	5102	79666236
Lymphadenopathy	30.22	16.70	6	73044	53241	79618097
Rhinorrhoea	30.17	16.70	16	73034	76058	79595280
Influenza like illness	30.06	16.70	14	73036	71693	79599645
Toxic epidermal necrolysis	30.02	16.70	3	73047	44578	79626760
Folliculitis	29.88	16.70	115	72935	55265	79616073
Transient ischaemic attack	29.77	16.70	6	73044	52689	79618649
Injection site swelling	29.67	16.70	4	73046	47128	79624210
Skin exfoliation	29.66	16.70	7	73043	55093	79616245
Weight increased	29.56	16.70	142	72908	277244	79394094
Drug eruption	29.47	16.70	3	73047	43932	79627406
Acute myocardial infarction	29.39	16.70	17	73033	77019	79594319
Peripheral swelling	29.33	16.70	137	72913	269480	79401858
Suicidal behaviour	29.09	16.70	24	73026	3223	79668115
Iodine allergy	28.86	16.70	13	73037	578	79670760
Abnormal behaviour	28.82	16.70	86	72964	36335	79635003
Respiratory tract infection	28.67	16.70	5	73045	48684	79622654
Ill-defined disorder	28.63	16.70	128	72922	65747	79605591
Palpitations	28.41	16.70	45	73005	126565	79544773
Clostridium difficile infection	28.41	16.70	3	73047	42682	79628656
Ascites	28.37	16.70	17	73033	75545	79595793
Bone pain	28.25	16.70	8	73042	55734	79615604
Accidental poisoning	28.04	16.70	18	73032	1639	79669699
Cluster headache	27.91	16.70	15	73035	981	79670357
Brain death	27.78	16.70	30	73020	5647	79665691
Fungal infection	27.62	16.70	3	73047	41745	79629593
Dysgeusia	27.54	16.70	9	73041	57168	79614170
Lymphocyte count decreased	27.53	16.70	5	73045	47284	79624054
Myocardial fibrosis	27.44	16.70	18	73032	1700	79669638
Osteoporosis	26.99	16.70	8	73042	54104	79617234
Blood pH decreased	26.83	16.70	27	73023	4684	79666654
Asthma	26.70	16.70	52	72998	135043	79536295
Duodenal ulcer perforation	26.08	16.70	125	72925	66086	79605252
Drug interaction	26.03	16.70	529	72521	414654	79256684
Mobility decreased	25.95	16.70	45	73005	122130	79549208
Exposure via inhalation	25.90	16.70	8	73042	120	79671218
Dysphonia	25.60	16.70	10	73040	56862	79614476
Hypoaesthesia	25.36	16.70	82	72968	179270	79492068
Housebound	24.94	16.70	11	73039	465	79670873
Coma scale abnormal	24.83	16.70	35	73015	8643	79662695
Nasopharyngitis	24.76	16.70	134	72916	253747	79417591
Drug diversion	24.74	16.70	15	73035	1235	79670103
Respiratory acidosis	24.69	16.70	40	73010	11160	79660178
Pain in jaw	24.57	16.70	6	73044	46145	79625193
Infusion related reaction	24.44	16.70	118	72932	230119	79441219
Red blood cell sedimentation rate increased	24.41	16.70	6	73044	45936	79625402
Bezoar	24.36	16.70	20	73030	2668	79668670
Hypothermia	24.31	16.70	60	72990	22686	79648652
Pulmonary hypertension	24.18	16.70	7	73043	48073	79623265
Hepatotoxicity	24.01	16.70	102	72948	51250	79620088
Maternal exposure timing unspecified	23.89	16.70	28	73022	5764	79665574
Accidental exposure to product	23.88	16.70	73	72977	31249	79640089
Blood pressure systolic increased	23.87	16.70	16	73034	66970	79604368
Migraine	23.79	16.70	27	73023	87466	79583872
Hospitalisation	23.60	16.70	31	73019	94205	79577133
Analgesic drug level increased	23.41	16.70	21	73029	3157	79668181
Hepatic fibrosis	23.31	16.70	31	73019	7249	79664089
Blood creatinine increased	23.26	16.70	69	72981	154988	79516350
Delirium tremens	23.19	16.70	12	73038	726	79670612
Cerebral haemorrhage	23.06	16.70	12	73038	57661	79613677
Gun shot wound	23.05	16.70	14	73036	1156	79670182
Hepatitis C virus test positive	23.03	16.70	10	73040	407	79670931
Hepatic failure	22.98	16.70	114	72936	61098	79610240
Red blood cell count decreased	22.94	16.70	12	73038	57501	79613837
Protein C increased	22.73	16.70	7	73043	104	79671234
Presyncope	22.53	16.70	5	73045	41049	79630289
Throat irritation	22.44	16.70	5	73045	40941	79630397
Hypothyroidism	22.32	16.70	10	73040	52382	79618956
Impaired driving ability	22.04	16.70	26	73024	5389	79665949
Euphoric mood	21.87	16.70	31	73019	7695	79663643
Rash erythematous	21.68	16.70	13	73037	57756	79613582
Nephrolithiasis	21.44	16.70	11	73039	53280	79618058
Urticaria	21.39	16.70	92	72958	185109	79486229
Dysarthria	21.32	16.70	120	72930	67502	79603836
Haematuria	21.28	16.70	19	73031	68817	79602521
Blood glucose increased	21.24	16.70	46	73004	114929	79556409
Illness	21.23	16.70	8	73042	46503	79624835
Melaena	21.09	16.70	15	73035	60875	79610463
Hot flush	21.09	16.70	12	73038	54865	79616473
Breast cancer	20.95	16.70	3	73047	33778	79637560
Muscle spasms	20.68	16.70	86	72964	174644	79496694
Haematoma	20.66	16.70	11	73039	52184	79619154
Balance disorder	20.46	16.70	37	73013	98820	79572518
Viral infection	20.32	16.70	7	73043	43009	79628329
Visceral congestion	20.29	16.70	12	73038	944	79670394
Candida infection	20.28	16.70	5	73045	38209	79633129
Compartment syndrome	20.02	16.70	24	73026	5058	79666280
Brain injury	19.98	16.70	37	73013	11480	79659858
Swollen tongue	19.98	16.70	7	73043	42563	79628775
Electrocardiogram ST segment elevation	19.90	16.70	31	73019	8366	79662972
Alcoholic liver disease	19.82	16.70	10	73040	574	79670764
Gastric disorder	19.67	16.70	5	73045	37428	79633910
Dyspepsia	19.65	16.70	44	73006	108643	79562695
Sudden death	19.59	16.70	55	72995	22456	79648882
Disease recurrence	19.46	16.70	8	73042	44101	79627237
Hepatitis alcoholic	19.25	16.70	10	73040	610	79670728
Pericarditis	19.15	16.70	162	72888	104074	79567264
Vertigo	19.13	16.70	21	73029	69061	79602277
Hypocalcaemia	19.07	16.70	11	73039	49913	79621425
Therapy interrupted	18.94	16.70	3	73047	31338	79640000
Paraesthesia	18.92	16.70	90	72960	176233	79495105
Skin disorder	18.90	16.70	4	73046	33939	79637399
Gastric ulcer	18.87	16.70	4	73046	33901	79637437
Eczema	18.67	16.70	7	73043	40811	79630527
Anaphylactic reaction	18.56	16.70	30	73020	83713	79587625
Induced abortion failed	18.48	16.70	7	73043	199	79671139
Respiratory failure	18.46	16.70	94	72956	180817	79490521
Neuralgia	18.45	16.70	4	73046	33380	79637958
Product prescribing error	18.40	16.70	9	73041	44804	79626534
Sleep disorder	18.39	16.70	138	72912	85539	79585799
Areflexia	18.39	16.70	24	73026	5510	79665828
Alcoholic	18.32	16.70	5	73045	47	79671291
Visceral oedema	18.26	16.70	6	73044	111	79671227
Ischaemic stroke	18.25	16.70	4	73046	33127	79638211
Pulmonary toxicity	18.18	16.70	38	73012	12876	79658462
Conjunctival scar	18.13	16.70	7	73043	210	79671128
Multiple injuries	18.04	16.70	19	73031	3476	79667862
Blood pressure diastolic decreased	18.02	16.70	3	73047	30213	79641125
Blood methanol increased	17.99	16.70	3	73047	0	79671338
Localised infection	17.95	16.70	6	73044	37569	79633769
Substance-induced mood disorder	17.87	16.70	6	73044	119	79671219
Behavioural addiction	17.61	16.70	5	73045	55	79671283
Hip arthroplasty	17.47	16.70	72	72978	35684	79635654
Behaviour disorder	17.38	16.70	25	73025	6288	79665050
Blood lactic acid increased	17.36	16.70	37	73013	12707	79658631
Burning sensation	17.16	16.70	17	73033	58615	79612723
Fatty liver alcoholic	17.06	16.70	5	73045	62	79671276
Coronary artery disease	16.95	16.70	21	73029	65453	79605885
Hypervolaemia	16.89	16.70	9	73041	42681	79628657
Electrocardiogram repolarisation abnormality	16.74	16.70	15	73035	2252	79669086
Altered state of consciousness	16.73	16.70	82	72968	43740	79627598

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	D08AX08	DERMATOLOGICALS ANTISEPTICS AND DISINFECTANTS ANTISEPTICS AND DISINFECTANTS Other antiseptics and disinfectants
ATC	V03AB16	VARIOUS ALL OTHER THERAPEUTIC PRODUCTS ALL OTHER THERAPEUTIC PRODUCTS Antidotes
ATC	V03AZ01	VARIOUS ALL OTHER THERAPEUTIC PRODUCTS ALL OTHER THERAPEUTIC PRODUCTS Nerve depressants
MeSH PA	D000890	Anti-Infective Agents
MeSH PA	D000891	Anti-Infective Agents, Local
MeSH PA	D002491	Central Nervous System Agents
MeSH PA	D002492	Central Nervous System Depressants
MeSH PA	D012997	Solvents
CHEBI has role	CHEBI:35488	central nervous system depressants
CHEBI has role	CHEBI:48218	antiseptics
CHEBI has role	CHEBI:48219	disinfectants
CHEBI has role	CHEBI:48354	polar solvent
CHEBI has role	CHEBI:50905	teratogeno
CHEBI has role	CHEBI:50910	agente neurotoxico
CHEBI has role	CHEBI:60643	N-methyl-D-aspartate receptor antagonists
CHEBI has role	CHEBI:64018	protein kinase C agonists
CHEBI has role	CHEBI:75771	Mus musculus metabolites
CHEBI has role	CHEBI:75772	S. cerevisiae metabolites
CHEBI has role	CHEBI:76971	Escherichia coli metabolites
CHEBI has role	CHEBI:77746	Homo sapiens metabolite

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Antiseptic preparation	indication	261276004

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

Formulation strength	Trade name	Applicant	Application number	Approval date	Type	Dose form	Route	Exclusivity date	Description
99% (1ML)	ABLYSINOL	BPI LABS	N207987	June 21, 2018	RX	SOLUTION	INTRA-ARTERIAL	June 21, 2025	INDICATED TO INDUCE CONTROLLED CARDIAC SEPTAL INFRACTION TO IMPROVE EXERCISE CAPACITY IN ADULTS WITH SYMPTOMATIC HYPERTROPHIC OBSTRUCTIVE CARDIOMYOPATHY WHO ARE NOT CANDIDATES FOR SURGICAL MYECTOMY
99% (5ML)	ABLYSINOL	BPI LABS	N207987	June 21, 2018	RX	SOLUTION	INTRA-ARTERIAL	June 21, 2025	INDICATED TO INDUCE CONTROLLED CARDIAC SEPTAL INFRACTION TO IMPROVE EXERCISE CAPACITY IN ADULTS WITH SYMPTOMATIC HYPERTROPHIC OBSTRUCTIVE CARDIOMYOPATHY WHO ARE NOT CANDIDATES FOR SURGICAL MYECTOMY

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Glycine receptor subunit alpha-1	Ion channel	P23415	GLRA1_HUMAN					WOMBAT-PK
Glycine receptor subunit alpha-2	Ion channel	P23416	GLRA2_HUMAN					WOMBAT-PK
Glutamate receptor ionotropic, NMDA 3A	Ion channel	Q8TCU5	NMD3A_HUMAN					WOMBAT-PK
GABA A receptor alpha-4/beta-2/delta	Ion channel	O14764 P47870 P48169	GBRD_HUMAN GBRB2_HUMAN GBRA4_HUMAN					WOMBAT-PK

External reference:

ID	Source
4017736	VUID
N0000146104	NUI
D06542	KEGG_DRUG
4017424	VANDF
4017736	VANDF
C0001962	UMLSCUI
CHEBI:16236	CHEBI
EOH	PDB_CHEM_ID
CHEMBL545	ChEMBL_ID
702	PUBCHEM_CID
DB00898	DRUGBANK_ID
D000431	MESH_DESCRIPTOR_UI
2299	IUPHAR_LIGAND_ID
448	RXNORM
10010	MMSL
4693	MMSL
9888	MMSL
d03162	MMSL
001539	NDDF
002464	NDDF
398624005	SNOMEDCT_US
419442005	SNOMEDCT_US
3K9958V90M	UNII

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
TRISEPTINHAND AND BODY ANTISEPTIC	HUMAN OTC DRUG LABEL	1	0064-1050	LOTION	0.70 mL	TOPICAL	OTC monograph not final	9 sections
SURGICEPT Waterless, Surgical Handscrub and Healthcare Personnel Handwash	HUMAN OTC DRUG LABEL	1	0064-1080	SOLUTION	0.75 mL	TOPICAL	OTC monograph not final	10 sections
hand sanitizer	HUMAN OTC DRUG LABEL	1	0113-7077	GEL	70 mL	TOPICAL	OTC monograph not final	12 sections
Humphreys Alcoholado Maravilla	HUMAN OTC DRUG LABEL	1	0219-2020	LIQUID	70 mL	TOPICAL	OTC MONOGRAPH NOT FINAL	13 sections
Nozin Nasal Sanitizer	HUMAN OTC DRUG LABEL	1	0295-9025	LIQUID	62 mL	TOPICAL	OTC monograph not final	9 sections
Keri Clinical Care Hand Sanitizing Gel - HEALTHCARE	HUMAN OTC DRUG LABEL	1	0316-0214	GEL	0.70 mL	TOPICAL	OTC monograph not final	11 sections
Keri Clinical Care Hand Sanitizing Gel	HUMAN OTC DRUG LABEL	1	0316-0292	GEL	0.70 mL	TOPICAL	OTC monograph not final	11 sections
SeptoSan Hand Sanitizer	HUMAN OTC DRUG LABEL	1	0362-6000	LIQUID	60 L	TOPICAL	OTC MONOGRAPH NOT FINAL	14 sections
SeptoSan Hand Sanitizer	HUMAN OTC DRUG LABEL	1	0362-6001	LIQUID	60 L	TOPICAL	OTC MONOGRAPH NOT FINAL	14 sections
SeptoSan Hand Sanitizer	HUMAN OTC DRUG LABEL	1	0362-6002	LIQUID	60 L	TOPICAL	OTC MONOGRAPH NOT FINAL	14 sections
Alcohol	HUMAN OTC DRUG LABEL	1	0363-0046	LIQUID	62 mg	TOPICAL	OTC monograph not final	12 sections
Alcohol	HUMAN OTC DRUG LABEL	1	0363-0046	LIQUID	62 mg	TOPICAL	OTC monograph not final	12 sections
Alcohol	HUMAN OTC DRUG LABEL	1	0363-0046	LIQUID	62 mL	TOPICAL	OTC monograph not final	12 sections
Iodine	HUMAN OTC DRUG LABEL	3	0363-0088	LIQUID	470 mg	TOPICAL	OTC monograph not final	12 sections
Advanced Hand Sanitizer	HUMAN OTC DRUG LABEL	1	0363-0370	GEL	70 mL	TOPICAL	OTC monograph not final	12 sections
Advanced Hand Sanitizer	HUMAN OTC DRUG LABEL	1	0363-0370	GEL	70 mL	TOPICAL	OTC monograph not final	12 sections
Hand Sanitizer	HUMAN OTC DRUG LABEL	1	0363-0469	GEL	545 mg	TOPICAL	OTC monograph not final	12 sections
Hand Sanitizer	HUMAN OTC DRUG LABEL	1	0363-0469	GEL	545 mg	TOPICAL	OTC monograph not final	12 sections
Hand Sanitizer	HUMAN OTC DRUG LABEL	1	0363-0596	GEL	63 mL	TOPICAL	OTC monograph not final	12 sections
Hand Sanitizer	HUMAN OTC DRUG LABEL	1	0363-0596	GEL	567 mg	TOPICAL	OTC monograph not final	12 sections
Hand Sanitizer	HUMAN OTC DRUG LABEL	1	0363-0643	GEL	558 mg	TOPICAL	OTC monograph not final	11 sections
Hand Sanitizer	HUMAN OTC DRUG LABEL	1	0363-0643	GEL	558 mg	TOPICAL	OTC monograph not final	11 sections
Crisp Apple Hand Sani	HUMAN OTC DRUG LABEL	1	0363-0663	LIQUID	585 g	TOPICAL	OTC monograph not final	13 sections
Walgreens	HUMAN OTC DRUG LABEL	1	0363-0859	GEL	700 mg	TOPICAL	OTC monograph not final	12 sections
Ethyl Rubbing Alcohol	HUMAN OTC DRUG LABEL	1	0363-0876	LIQUID	610 mg	TOPICAL	OTC monograph not final	13 sections
Ethyl Rubbing Alcohol	HUMAN OTC DRUG LABEL	1	0363-0876	LIQUID	70 mL	TOPICAL	OTC monograph not final	13 sections
Ethyl Rubbing Alcohol	HUMAN OTC DRUG LABEL	1	0363-0876	LIQUID	610 mg	TOPICAL	OTC monograph not final	13 sections
Hand Sanitizer	HUMAN OTC DRUG LABEL	1	0363-0890	GEL	567 mg	TOPICAL	OTC monograph not final	11 sections
Hand Sanitizer	HUMAN OTC DRUG LABEL	1	0363-0890	GEL	567 mg	TOPICAL	OTC monograph not final	11 sections
Hand Sanitizer	HUMAN OTC DRUG LABEL	1	0363-0898	GEL	567 mg	TOPICAL	OTC monograph not final	11 sections