ethanol ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
1076 64-17-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • alcohol
  • ethanol
  • ethyl alcohol
  • grain alcohol
A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in ALCOHOLIC BEVERAGES.
  • Molecular weight: 46.07
  • Formula: C2H6O
  • CLOGP: -0.24
  • LIPINSKI: 0
  • HAC: 1
  • HDO: 1
  • TPSA: 20.23
  • ALOGS: 1.10
  • ROTB: 0

Drug dosage:

None

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 2.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 2170.63 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 80 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
Jan. 17, 1946 FDA B BRAUN

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 8675.59 16.77 3516 47566 142157 63295783
Toxicity to various agents 4675.07 16.77 2727 48355 244523 63193417
Drug abuse 3176.47 16.77 1416 49666 71102 63366838
Cardio-respiratory arrest 1721.55 16.77 877 50205 59082 63378858
Intentional overdose 1292.43 16.77 781 50301 73371 63364569
Respiratory arrest 1070.15 16.77 523 50559 32122 63405818
Overdose 951.75 16.77 767 50315 114311 63323629
Cardiac arrest 790.69 16.77 629 50453 91916 63346024
Poisoning 786.75 16.77 325 50757 13375 63424565
Suicide attempt 740.39 16.77 512 50570 60406 63377534
Intentional product misuse 640.99 16.77 469 50613 60448 63377492
Alcohol interaction 517.57 16.77 153 50929 2256 63435684
Death 470.02 16.77 970 50112 373411 63064529
Drug hypersensitivity 423.00 16.77 833 50249 309854 63128086
Alcohol poisoning 408.42 16.77 121 50961 1798 63436142
Alcohol use 394.58 16.77 120 50962 1959 63435981
Suspected suicide 327.51 16.77 141 50941 6427 63431513
Exposure via ingestion 315.97 16.77 110 50972 2799 63435141
Alcohol abuse 236.36 16.77 82 51000 2064 63435876
Exposure to toxic agent 196.36 16.77 94 50988 5493 63432447
Coma 195.76 16.77 250 50832 64114 63373826
Diarrhoea 195.00 16.77 174 50908 715192 62722748
Poisoning deliberate 171.67 16.77 109 50973 11109 63426831
Irritable bowel syndrome 153.78 16.77 254 50828 82158 63355782
Blood alcohol increased 147.02 16.77 43 51039 609 63437331
Pneumonia 142.02 16.77 97 50985 456670 62981270
Nausea 137.70 16.77 303 50779 854168 62583772
Helicobacter infection 133.22 16.77 255 50827 92530 63345410
Gastrointestinal toxicity 130.52 16.77 80 51002 7661 63430279
Muscle injury 125.40 16.77 204 50878 65141 63372799
Headache 125.31 16.77 198 50884 633043 62804897
Fatigue 123.39 16.77 340 50742 887688 62550252
Folliculitis 122.23 16.77 210 50872 70107 63367833
Anaemia 118.53 16.77 44 51038 293386 63144554
Mydriasis 116.47 16.77 88 50994 11868 63426072
Asthenia 114.52 16.77 85 50997 383519 63054421
Ill-defined disorder 114.06 16.77 222 50860 81533 63356407
Pulmonary toxicity 113.54 16.77 79 51003 9376 63428564
Product dose omission issue 111.27 16.77 26 51056 234287 63203653
Cough 108.38 16.77 50 51032 292693 63145247
Somnolence 108.29 16.77 353 50729 178332 63259608
Urinary tract infection 106.36 16.77 40 51042 264644 63173296
Methaemoglobinaemia 104.92 16.77 47 51035 2356 63435584
Neutropenia 99.42 16.77 12 51070 174993 63262947
Substance abuse 94.90 16.77 55 51027 4752 63433188
Drug ineffective 93.50 16.77 479 50603 1044286 62393654
Duodenal ulcer perforation 92.78 16.77 212 50870 86997 63350943
Alcoholism 90.52 16.77 39 51043 1779 63436161
Medication error 89.34 16.77 155 50927 52129 63385811
Blister 87.37 16.77 266 50816 129548 63308392
Malaise 83.11 16.77 129 50953 415825 63022115
Agitation 81.78 16.77 161 50921 59596 63378344
Fall 80.95 16.77 119 50963 392215 63045725
Back pain 80.75 16.77 57 51025 264088 63173852
Off label use 79.41 16.77 278 50804 674184 62763756
Disease progression 78.94 16.77 5 51077 122753 63315187
Constipation 76.37 16.77 43 51039 224900 63213040
Intentional self-injury 75.26 16.77 98 50984 25589 63412351
Pericarditis 75.25 16.77 255 50827 131324 63306616
Impaired healing 74.57 16.77 216 50866 102326 63335614
Drug dependence 69.54 16.77 92 50990 24391 63413549
Dyspnoea 69.13 16.77 286 50796 661027 62776913
Hepatotoxicity 67.48 16.77 113 50969 36928 63401012
Thrombocytopenia 67.45 16.77 19 51063 151138 63286802
White blood cell count decreased 66.87 16.77 15 51067 139089 63298851
Pain 65.76 16.77 340 50742 740288 62697652
Dizziness 65.24 16.77 157 50925 429768 63008172
Sepsis 65.15 16.77 21 51061 153102 63284838
Febrile neutropenia 65.14 16.77 9 51073 118440 63319500
Postmortem blood drug level abnormal 65.10 16.77 20 51062 338 63437602
Victim of sexual abuse 63.41 16.77 23 51059 661 63437279
Contusion 62.71 16.77 263 50819 149781 63288159
Drug abuser 61.87 16.77 35 51047 2888 63435052
Cerebrovascular accident 59.89 16.77 8 51074 108016 63329924
Cardiac failure congestive 58.73 16.77 4 51078 92429 63345511
Liver injury 57.69 16.77 141 50941 60379 63377561
Sleep disorder due to general medical condition, insomnia type 55.57 16.77 127 50955 52090 63385850
Bronchitis 55.19 16.77 16 51066 124919 63313021
Haemoglobin decreased 55.11 16.77 24 51058 145461 63292479
Blood pressure increased 54.96 16.77 31 51051 162031 63275909
Dehydration 54.82 16.77 36 51046 173318 63264622
COVID-19 54.75 16.77 12 51070 113091 63324849
Pancytopenia 54.17 16.77 7 51075 96926 63341014
Accidental death 53.92 16.77 28 51054 1948 63435992
Decreased appetite 53.84 16.77 74 51008 250978 63186962
Drug use disorder 53.74 16.77 39 51043 4945 63432995
Chemical submission 52.32 16.77 16 51066 266 63437674
Weight decreased 52.25 16.77 89 50993 276709 63161231
Loss of consciousness 51.66 16.77 210 50872 117911 63320029
Platelet count decreased 51.05 16.77 15 51067 116107 63321833
Therapy non-responder 50.53 16.77 155 50927 75746 63362194
Blood ethanol increased 50.20 16.77 13 51069 113 63437827
Injection site pain 49.82 16.77 21 51061 129779 63308161
Victim of chemical submission 49.73 16.77 18 51064 514 63437426
Joint injury 49.63 16.77 87 50995 29485 63408455
Neuropathy peripheral 49.40 16.77 15 51067 113652 63324288
Malignant neoplasm progression 48.20 16.77 5 51077 82116 63355824
Swollen joint count increased 47.94 16.77 96 50986 35958 63401982
C-reactive protein abnormal 47.82 16.77 111 50971 45985 63391955
Lower respiratory tract infection 47.75 16.77 222 50860 132085 63305855
Acute kidney injury 47.63 16.77 87 50995 263328 63174612
Hepatic failure 47.48 16.77 95 50987 35561 63402379
Aggression 47.29 16.77 75 51007 23423 63414517
Arthropathy 46.61 16.77 336 50746 234456 63203484
Gastrooesophageal reflux disease 46.59 16.77 10 51072 95629 63342311
Myocarditis 46.28 16.77 49 51033 10276 63427664
Pulmonary embolism 46.21 16.77 18 51064 116666 63321274
Unresponsive to stimuli 46.12 16.77 91 50991 33725 63404215
Iodine allergy 45.87 16.77 19 51063 785 63437155
Anti-cyclic citrullinated peptide antibody positive 45.68 16.77 200 50882 116012 63321928
Psoriasis 44.65 16.77 8 51074 86949 63350991
Leukopenia 44.62 16.77 5 51077 77285 63360655
Influenza 44.35 16.77 16 51066 108706 63329234
Injection site erythema 44.15 16.77 7 51075 83167 63354773
Road traffic accident 43.38 16.77 93 50989 36539 63401401
Gastrointestinal disorder 42.88 16.77 214 50868 131025 63306915
Neoplasm malignant 42.72 16.77 82 51000 29779 63408161
Rheumatic fever 41.68 16.77 101 50981 43010 63394930
Erythema 41.63 16.77 48 51034 175703 63262237
Electrocardiogram QRS complex prolonged 41.49 16.77 36 51046 5902 63432038
Herpes zoster 41.46 16.77 8 51074 82454 63355486
Discomfort 40.71 16.77 252 50830 167122 63270818
Depressed level of consciousness 40.59 16.77 126 50956 61952 63375988
Metabolic acidosis 39.79 16.77 102 50980 44967 63392973
Pyrexia 39.39 16.77 220 50862 470258 62967682
Asphyxia 38.28 16.77 35 51047 6146 63431794
Tachycardia 38.12 16.77 192 50890 117964 63319976
Arthritis 38.12 16.77 23 51059 115898 63322042
Rheumatoid factor positive 37.64 16.77 151 50931 84255 63353685
Hepatic enzyme increased 37.55 16.77 285 50797 202043 63235897
Somnambulism 37.51 16.77 33 51049 5510 63432430
Infection 37.18 16.77 313 50769 228860 63209080
Septic shock 36.77 16.77 5 51077 66624 63371316
Congestive hepatopathy 36.30 16.77 25 51057 2917 63435023
Injection site reaction 35.85 16.77 3 51079 58521 63379419
Abdominal pain 35.71 16.77 119 50963 293337 63144603
Hyponatraemia 35.69 16.77 23 51059 111877 63326063
Seizure 35.64 16.77 205 50877 132429 63305511
Substance use disorder 35.26 16.77 11 51071 196 63437744
Epistaxis 34.62 16.77 8 51074 72717 63365223
Drug withdrawal syndrome 34.48 16.77 71 51011 27123 63410817
Neck pain 34.27 16.77 7 51075 69311 63368629
Palpitations 33.55 16.77 25 51057 112745 63325195
Vision blurred 33.50 16.77 16 51066 91908 63346032
Pain in extremity 33.49 16.77 145 50937 331341 63106599
Electrocardiogram QT prolonged 32.80 16.77 114 50968 59416 63378524
C-reactive protein increased 32.26 16.77 18 51064 94689 63343251
Homicide 32.19 16.77 12 51070 373 63437567
Maternal exposure timing unspecified 30.65 16.77 33 51049 7054 63430886
Suicidal ideation 30.54 16.77 115 50967 62306 63375634
Intentional product use issue 30.11 16.77 191 50891 127701 63310239
Housebound 29.91 16.77 10 51072 224 63437716
Confusional state 29.85 16.77 306 50776 236074 63201866
Hip arthroplasty 29.58 16.77 95 50987 47551 63390389
Sleep disorder 29.51 16.77 137 50945 81429 63356511
Drug screen positive 29.48 16.77 24 51058 3605 63434335
Oropharyngeal pain 29.35 16.77 20 51062 94467 63343473
Respiratory depression 29.30 16.77 45 51037 13670 63424270
Myocardial infarction 28.63 16.77 23 51059 99870 63338070
Renal impairment 28.39 16.77 18 51064 88337 63349603
Cystitis 28.36 16.77 5 51077 54986 63382954
Chest discomfort 28.30 16.77 28 51054 109941 63327999
Gastrointestinal haemorrhage 28.27 16.77 15 51067 81161 63356779
Rash 28.19 16.77 302 50780 560569 62877371
Sinus tachycardia 28.03 16.77 61 51021 24207 63413733
Rhinorrhoea 27.86 16.77 9 51073 65568 63372372
Electrocardiogram ST segment elevation 27.83 16.77 24 51058 3903 63434037
Protein C increased 27.50 16.77 8 51074 111 63437829
Abdominal distension 27.35 16.77 18 51064 86597 63351343
Muscular weakness 27.29 16.77 35 51047 122318 63315622
Mucosal inflammation 27.17 16.77 3 51079 46925 63391015
Hepatic encephalopathy 26.94 16.77 39 51043 11243 63426697
Productive cough 26.29 16.77 9 51073 63199 63374741
Accidental overdose 26.25 16.77 58 51024 23251 63414689
Nasal congestion 26.20 16.77 10 51072 65650 63372290
Inappropriate schedule of product administration 26.15 16.77 27 51055 103938 63334002
Disinhibition 25.50 16.77 13 51069 870 63437070
Brain oedema 25.44 16.77 43 51039 14152 63423788
Product administration interrupted 25.40 16.77 25 51057 4811 63433129
Influenza like illness 25.33 16.77 11 51071 66813 63371127
Injection site swelling 25.25 16.77 4 51078 47568 63390372
Environmental exposure 24.85 16.77 7 51075 86 63437854
Balance disorder 24.74 16.77 19 51063 84403 63353537
Knee arthroplasty 24.18 16.77 97 50985 54109 63383831
Chest pain 23.97 16.77 91 50991 215868 63222072
Hyperkalaemia 23.82 16.77 7 51075 54196 63383744
Syncope 23.76 16.77 36 51046 117349 63320591
Aspiration 23.74 16.77 36 51046 10815 63427125
Neutrophil count decreased 23.51 16.77 8 51074 56398 63381542
Haematochezia 23.37 16.77 7 51075 53537 63384403
Cellulitis 23.32 16.77 19 51063 81939 63356001
Substance dependence 23.26 16.77 8 51074 196 63437744
Deep vein thrombosis 23.14 16.77 20 51062 83780 63354160
Incorrect route of product administration 23.07 16.77 61 51021 27391 63410549
Loss of personal independence in daily activities 22.56 16.77 27 51055 97263 63340677
Myalgia 22.56 16.77 53 51029 146476 63291464
Thrombosis 22.50 16.77 12 51070 64743 63373197
Bone pain 22.34 16.77 8 51074 54633 63383307
Interstitial lung disease 22.21 16.77 11 51071 61897 63376043
Dry skin 22.15 16.77 9 51073 56878 63381062
Muscle spasms 22.08 16.77 59 51023 156091 63281849
Toxicologic test abnormal 21.95 16.77 11 51071 710 63437230
Feeling abnormal 21.80 16.77 55 51027 148337 63289603
Breast cancer 21.72 16.77 6 51076 48377 63389563
Induced abortion failed 21.61 16.77 8 51074 244 63437696
Haematocrit decreased 21.59 16.77 3 51079 39337 63398603
Diabetes mellitus 21.45 16.77 9 51073 55801 63382139
Stomatitis 21.17 16.77 187 50895 138538 63299402
Upper respiratory tract infection 20.98 16.77 21 51061 82026 63355914
Rash pruritic 20.89 16.77 11 51071 59788 63378152
Chills 20.86 16.77 37 51045 113341 63324599
Red blood cell sedimentation rate increased 20.61 16.77 5 51077 43977 63393963
Alcohol withdrawal syndrome 20.53 16.77 11 51071 816 63437124
Gait disturbance 20.44 16.77 77 51005 183101 63254839
Dysphagia 20.10 16.77 25 51057 88560 63349380
Congenital umbilical hernia 19.92 16.77 8 51074 305 63437635
Hand deformity 19.90 16.77 206 50876 159251 63278689
Amnesia 19.83 16.77 93 50989 55492 63382448
Joint stiffness 19.54 16.77 76 51006 41793 63396147
Diverticulitis 19.54 16.77 4 51078 39553 63398387
Dysphonia 19.42 16.77 7 51075 47607 63390333
Fluid retention 19.39 16.77 12 51070 59674 63378266
Sopor 19.39 16.77 50 51032 22114 63415826
Lupus vulgaris 19.34 16.77 24 51058 5970 63431970
Visceral congestion 19.28 16.77 8 51074 332 63437608
Oedema peripheral 19.05 16.77 83 50999 189428 63248512
Alcoholic 18.96 16.77 5 51077 47 63437893
Acute hepatic failure 18.86 16.77 44 51038 18283 63419657
Blood pH decreased 18.72 16.77 16 51066 2571 63435369
Brain death 18.61 16.77 18 51064 3392 63434548
Chronic obstructive pulmonary disease 18.51 16.77 14 51068 62672 63375268
Deep vein thrombosis postoperative 18.49 16.77 33 51049 11336 63426604
Cognitive disorder 18.45 16.77 11 51071 55804 63382136
Miosis 18.41 16.77 26 51056 7327 63430613
Blood methanol increased 18.38 16.77 3 51079 0 63437940
C-reactive protein 18.14 16.77 21 51061 4861 63433079
Areflexia 18.04 16.77 17 51065 3101 63434839
Gastric disorder 18.01 16.77 4 51078 37365 63400575
Lip dry 18.00 16.77 39 51043 15431 63422509
Osteoporosis 17.99 16.77 12 51070 57326 63380614
Postmortem blood drug level 17.84 16.77 6 51076 137 63437803
Pulmonary hypertension 17.83 16.77 4 51078 37119 63400821
Atrial fibrillation 17.31 16.77 43 51039 116593 63321347
Dyspnoea exertional 17.13 16.77 14 51068 60288 63377652
Cardio-respiratory distress 17.11 16.77 6 51076 156 63437784
Cholelithiasis 17.02 16.77 7 51075 43918 63394022
Facet joint syndrome 16.95 16.77 33 51049 12105 63425835
Vertigo 16.89 16.77 14 51068 59873 63378067

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug abuse 8933.59 20.73 3427 31989 95669 34825846
Completed suicide 6867.27 20.73 2834 32582 95334 34826181
Toxicity to various agents 5743.71 20.73 3124 32292 197238 34724277
Cardio-respiratory arrest 1595.84 20.73 875 34541 54398 34867117
Intentional product misuse 1184.16 20.73 674 34742 44937 34876578
Intentional overdose 1121.85 20.73 641 34775 43033 34878482
Poisoning 966.27 20.73 389 35027 11837 34909678
Overdose 947.66 20.73 763 34653 90296 34831219
Respiratory arrest 942.49 20.73 492 34924 27551 34893964
Alcohol abuse 663.89 20.73 229 35187 4461 34917054
Cardiac arrest 578.96 20.73 593 34823 95566 34825949
Suicide attempt 566.23 20.73 400 35016 38716 34882799
Alcohol interaction 534.65 20.73 173 35243 2740 34918775
Alcohol poisoning 526.25 20.73 180 35236 3413 34918102
Exposure via ingestion 472.55 20.73 147 35269 2034 34919481
Death 448.33 20.73 1133 34283 396916 34524599
Drug dependence 434.51 20.73 283 35133 23934 34897581
Substance abuse 410.34 20.73 185 35231 7456 34914059
Suspected suicide 343.75 20.73 142 35274 4606 34916909
Coma 330.68 20.73 312 35104 45366 34876149
Alcohol use 317.22 20.73 121 35295 3167 34918348
Asphyxia 315.47 20.73 149 35267 6686 34914829
Poisoning deliberate 290.11 20.73 147 35269 7697 34913818
Respiratory depression 227.51 20.73 163 35253 16082 34905433
Diarrhoea 217.94 20.73 63 35353 389849 34531666
Blood alcohol increased 210.36 20.73 63 35353 760 34920755
Pneumonia 200.01 20.73 60 35356 362567 34558948
Aggression 194.45 20.73 218 35198 38746 34882769
Drug ineffective 192.19 20.73 113 35303 456638 34464877
Exposure to toxic agent 187.84 20.73 86 35330 3589 34917926
Pyrexia 174.87 20.73 60 35356 332953 34588562
Anaemia 170.17 20.73 19 35397 233316 34688199
Fatigue 155.26 20.73 92 35324 370561 34550954
Dyspnoea 154.38 20.73 96 35320 376686 34544829
Accidental death 152.90 20.73 66 35350 2390 34919125
Off label use 150.82 20.73 123 35293 419401 34502114
Neutropenia 121.50 20.73 10 35406 156768 34764747
Rash 120.48 20.73 38 35378 222714 34698801
Accidental overdose 111.38 20.73 119 35297 20021 34901494
Miosis 107.41 20.73 84 35332 9451 34912064
Incorrect route of product administration 106.49 20.73 101 35315 14744 34906771
Drug use disorder 105.85 20.73 61 35355 4130 34917385
Nausea 102.89 20.73 116 35300 339792 34581723
Substance use disorder 102.34 20.73 36 35380 743 34920772
Intentional self-injury 101.28 20.73 95 35321 13676 34907839
Drug withdrawal syndrome 97.21 20.73 110 35306 19724 34901791
Febrile neutropenia 95.10 20.73 13 35403 136836 34784679
Cough 93.84 20.73 19 35397 150121 34771394
Depressed level of consciousness 93.65 20.73 161 35255 42680 34878835
Agitation 92.16 20.73 189 35227 57210 34864305
Sepsis 90.74 20.73 28 35388 166533 34754982
Arthralgia 90.12 20.73 30 35386 170011 34751504
Alcohol withdrawal syndrome 89.45 20.73 39 35377 1447 34920068
Prescription drug used without a prescription 87.38 20.73 43 35373 2111 34919404
Drug abuser 85.34 20.73 52 35364 3902 34917613
Alcoholism 85.29 20.73 47 35369 2918 34918597
Asthenia 85.27 20.73 74 35342 245177 34676338
Drug screen positive 82.92 20.73 51 35365 3892 34917623
Methaemoglobinaemia 82.21 20.73 49 35367 3532 34917983
Suicidal ideation 79.52 20.73 145 35271 40243 34881272
Mydriasis 77.74 20.73 62 35354 7175 34914340
Pain 77.07 20.73 57 35359 204618 34716897
Condition aggravated 77.04 20.73 50 35366 192146 34729369
Pain in extremity 75.01 20.73 18 35398 126495 34795020
Withdrawal syndrome 71.35 20.73 75 35341 12380 34909135
Product dose omission issue 71.03 20.73 17 35399 119694 34801821
Pruritus 70.21 20.73 28 35388 141953 34779562
Haemoglobin decreased 70.01 20.73 18 35398 120754 34800761
Malignant neoplasm progression 69.90 20.73 5 35411 88041 34833474
Pancytopenia 68.60 20.73 8 35408 95149 34826366
Decreased appetite 68.44 20.73 42 35374 166350 34755165
Intentional product use issue 68.20 20.73 172 35244 59644 34861871
Medication error 67.96 20.73 105 35311 25460 34896055
Platelet count decreased 67.22 20.73 19 35397 119698 34801817
Back pain 67.15 20.73 20 35396 121769 34799746
White blood cell count decreased 66.44 20.73 9 35407 95436 34826079
Unresponsive to stimuli 66.08 20.73 108 35308 27461 34894054
Dizziness 63.37 20.73 77 35339 218444 34703071
Thrombocytopenia 60.76 20.73 42 35374 156205 34765310
Environmental exposure 60.39 20.73 19 35397 273 34921242
Oedema peripheral 60.26 20.73 23 35393 119789 34801726
Alcohol intolerance 60.08 20.73 21 35395 425 34921090
Infection 57.83 20.73 11 35405 90904 34830611
Road traffic accident 57 20.73 79 35337 17371 34904144
Pulmonary oedema 56.62 20.73 139 35277 47390 34874125
Blood ethanol increased 53.91 20.73 20 35396 483 34921032
Sopor 52.27 20.73 63 35353 12073 34909442
Renal impairment 51.22 20.73 16 35400 94497 34827018
Loss of consciousness 51.21 20.73 192 35224 82475 34839040
Cardiac failure congestive 51.03 20.73 11 35405 83259 34838256
General physical health deterioration 50.50 20.73 34 35382 128235 34793280
Weight decreased 50.15 20.73 63 35353 176238 34745277
Atrial fibrillation 50.15 20.73 31 35385 122362 34799153
COVID-19 50.14 20.73 9 35407 77541 34843974
Nasopharyngitis 50.13 20.73 6 35410 69962 34851553
Metabolic acidosis 49.14 20.73 125 35291 43555 34877960
Pulmonary embolism 48.98 20.73 15 35401 89731 34831784
Tachycardia 48.51 20.73 192 35224 84580 34836935
Cerebrovascular accident 48.45 20.73 13 35403 84798 34836717
Drug intolerance 48.39 20.73 3 35413 59567 34861948
Neuropathy peripheral 47.12 20.73 13 35403 83250 34838265
Abdominal pain 47.02 20.73 58 35358 163560 34757955
Cardiac failure 46.74 20.73 17 35399 91231 34830284
Constipation 46.71 20.73 42 35374 136940 34784575
Chest pain 45.50 20.73 37 35379 126725 34794790
Myocardial infarction 45.16 20.73 34 35382 121051 34800464
Peripheral swelling 45.13 20.73 11 35405 76530 34844985
Ex-drug abuser 44.65 20.73 13 35403 141 34921374
Physical assault 43.90 20.73 22 35394 1123 34920392
Pleural effusion 43.83 20.73 14 35402 81532 34839983
Headache 43.49 20.73 86 35330 200549 34720966
Amnesia 43.22 20.73 88 35328 26475 34895040
Malaise 42.60 20.73 77 35339 185748 34735767
Urinary tract infection 42.50 20.73 16 35400 84065 34837450
Infusion related reaction 42.13 20.73 3 35413 53054 34868461
Homicide 41.67 20.73 20 35396 929 34920586
Shock 41.62 20.73 82 35334 24097 34897418
Somnolence 40.82 20.73 221 35195 110895 34810620
Dehydration 40.66 20.73 43 35373 129926 34791589
Neutrophil count decreased 40.26 20.73 3 35413 51101 34870414
Muscular weakness 40.10 20.73 12 35404 72885 34848630
Self-medication 39.84 20.73 28 35388 2675 34918840
Drug interaction 39.81 20.73 376 35040 225570 34695945
Therapeutic product effect incomplete 39.73 20.73 3 35413 50538 34870977
Septic shock 39.20 20.73 12 35404 71822 34849693
Weight increased 38.89 20.73 23 35393 93010 34828505
Urticaria 38.71 20.73 8 35408 62369 34859146
Bradypnoea 38.69 20.73 28 35388 2801 34918714
Joint swelling 38.60 20.73 7 35409 59883 34861632
Acute kidney injury 38.29 20.73 169 35247 304819 34616696
Deep vein thrombosis 37.26 20.73 10 35406 65238 34856277
Chills 36.85 20.73 18 35398 81025 34840490
Myalgia 36.29 20.73 20 35396 84090 34837425
Treatment failure 36.06 20.73 3 35413 46694 34874821
Suicidal behaviour 35.71 20.73 21 35395 1476 34920039
Erythema 35.64 20.73 23 35393 88757 34832758
Chronic obstructive pulmonary disease 35.52 20.73 4 35412 48914 34872601
Dysphagia 34.80 20.73 10 35406 62371 34859144
Cluster headache 34.54 20.73 15 35401 551 34920964
Thrombosis 34.53 20.73 5 35411 50453 34871062
Brain oedema 34.27 20.73 55 35361 13766 34907749
Abnormal behaviour 34.05 20.73 77 35339 24892 34896623
Leukopenia 33.41 20.73 11 35405 62845 34858670
Haematochezia 33.30 20.73 4 35412 46530 34874985
Gun shot wound 32.77 20.73 18 35398 1110 34920405
Renal failure 31.82 20.73 52 35364 130505 34791010
Toxicologic test abnormal 31.55 20.73 14 35402 542 34920973
Impaired driving ability 31.40 20.73 24 35392 2609 34918906
Opiates positive 30.96 20.73 14 35402 567 34920948
Hepatic fibrosis 30.49 20.73 30 35386 4577 34916938
Dyspnoea exertional 30.29 20.73 4 35412 43275 34878240
Stomatitis 29.59 20.73 4 35412 42510 34879005
Influenza 29.54 20.73 7 35409 49659 34871856
Behavioural addiction 29.44 20.73 8 35408 66 34921449
Prostate cancer 29.41 20.73 3 35413 39646 34881869
Blood ethanol 29.29 20.73 9 35407 119 34921396
Electrocardiogram QRS complex prolonged 28.97 20.73 30 35386 4864 34916651
Dysarthria 28.74 20.73 89 35327 34693 34886822
Sinusitis 28.57 20.73 4 35412 41398 34880117
Exposure via inhalation 28.44 20.73 7 35409 37 34921478
Acute hepatic failure 28.28 20.73 51 35365 14023 34907492
Foetal alcohol syndrome 28.19 20.73 9 35407 136 34921379
Pulmonary congestion 27.81 20.73 50 35366 13715 34907800
Musculoskeletal stiffness 26.94 20.73 7 35409 46673 34874842
Hepatitis C virus test positive 26.87 20.73 11 35405 348 34921167
Hospitalisation 26.85 20.73 12 35404 56890 34864625
Abdominal distension 26.57 20.73 13 35403 58479 34863036
Electrocardiogram repolarisation abnormality 26.39 20.73 15 35401 989 34920526
Acidosis 26.38 20.73 43 35373 10902 34910613
Hypersensitivity 25.62 20.73 15 35401 61020 34860495
Cellulitis 25.24 20.73 11 35405 52940 34868575
C-reactive protein increased 24.61 20.73 12 35404 54086 34867429
Haematuria 24.51 20.73 10 35406 50056 34871459
Dyspepsia 24.31 20.73 4 35412 36728 34884787
Chronic kidney disease 24.13 20.73 6 35410 41204 34880311
Accidental poisoning 24.04 20.73 13 35403 777 34920738
Pneumonitis 24.03 20.73 3 35413 33875 34887640
Myocardial fibrosis 23.94 20.73 15 35401 1182 34920333
Inappropriate schedule of product administration 23.85 20.73 17 35399 62279 34859236
Chest discomfort 23.46 20.73 13 35403 54517 34866998
Bronchitis 22.90 20.73 7 35409 41956 34879559
Hypertension 22.78 20.73 67 35349 136376 34785139
Pupil fixed 22.77 20.73 17 35399 1784 34919731
Accidental exposure to product 22.73 20.73 44 35372 12758 34908757
Therapeutic product effect decreased 22.51 20.73 4 35412 34739 34886776
Wheezing 22.43 20.73 7 35409 41395 34880120
Product use in unapproved indication 22.42 20.73 54 35362 117445 34804070
Legal problem 22.35 20.73 8 35408 174 34921341
Abdominal discomfort 22.03 20.73 17 35399 59818 34861697
Sensorimotor disorder 21.51 20.73 10 35406 432 34921083
Swelling 21.50 20.73 8 35408 42358 34879157
Dextrocardia 21.38 20.73 7 35409 115 34921400
Alcoholic liver disease 21.32 20.73 11 35405 597 34920918
Productive cough 21.20 20.73 6 35410 37807 34883708

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 15565.82 16.70 6414 66636 239353 79431985
Drug abuse 11793.44 16.70 4694 68356 157997 79513341
Toxicity to various agents 10213.10 16.70 5694 67356 415846 79255492
Cardio-respiratory arrest 3396.26 16.70 1753 71297 106757 79564581
Intentional overdose 2138.52 16.70 1284 71766 104676 79566662
Respiratory arrest 2099.76 16.70 1033 72017 56517 79614821
Intentional product misuse 1805.87 16.70 1109 71941 94056 79577282
Overdose 1754.21 16.70 1406 71644 182800 79488538
Poisoning 1733.18 16.70 706 72344 24566 79646772
Cardiac arrest 1441.84 16.70 1220 71830 170876 79500462
Death 1259.84 16.70 2020 71030 564494 79106844
Alcohol interaction 900.38 16.70 284 72766 4590 79666748
Suicide attempt 873.51 16.70 673 72377 82259 79589079
Alcohol poisoning 788.18 16.70 256 72794 4565 79666773
Alcohol use 767.40 16.70 251 72799 4580 79666758
Exposure via ingestion 766.42 16.70 255 72795 4919 79666419
Alcohol abuse 706.40 16.70 242 72808 5121 79666217
Suspected suicide 618.66 16.70 264 72786 10312 79661026
Coma 481.69 16.70 525 72525 100124 79571214
Drug dependence 448.94 16.70 340 72710 40429 79630909
Poisoning deliberate 441.43 16.70 252 72798 18576 79652762
Substance abuse 413.29 16.70 199 72851 10327 79661011
Exposure to toxic agent 374.35 16.70 178 72872 8980 79662358
Diarrhoea 368.46 16.70 174 72876 880315 78791023
Blood alcohol increased 305.18 16.70 91 72959 1204 79670134
Pneumonia 289.11 16.70 122 72928 660124 79011214
Asphyxia 288.56 16.70 162 72888 11558 79659780
Drug ineffective 277.98 16.70 351 72699 1080562 78590776
Fatigue 268.11 16.70 275 72775 929452 78741886
Drug hypersensitivity 268.01 16.70 737 72313 298179 79373159
Anaemia 253.62 16.70 50 73000 444965 79226373
Dyspnoea 239.66 16.70 260 72790 856765 78814573
Nausea 237.44 16.70 319 72731 956877 78714461
Off label use 230.42 16.70 297 72753 906918 78764420
Accidental death 205.22 16.70 93 72957 4198 79667140
Respiratory depression 196.63 16.70 179 72871 27451 79643887
Neutropenia 195.00 16.70 19 73031 287691 79383647
Drug abuser 186.81 16.70 97 72953 5916 79665422
Headache 186.21 16.70 195 72855 653577 79017761
Methaemoglobinaemia 182.33 16.70 93 72957 5464 79665874
Cough 180.20 16.70 56 72994 366733 79304605
Aggression 175.77 16.70 225 72825 50733 79620605
Asthenia 174.09 16.70 129 72921 511560 79159778
Mydriasis 172.08 16.70 137 72913 17506 79653832
Pyrexia 164.07 16.70 230 72820 678479 78992859
Agitation 162.93 16.70 312 72738 99403 79571935
Medication error 158.18 16.70 250 72800 68392 79602946
Intentional self-injury 156.44 16.70 170 72880 32249 79639089
Drug use disorder 148.95 16.70 95 72955 8556 79662782
Disease progression 146.47 16.70 5 73045 184357 79486981
Pain 144.21 16.70 266 72784 703536 78967802
Urinary tract infection 143.88 16.70 37 73013 274475 79396863
Febrile neutropenia 142.34 16.70 21 73029 230978 79440360
Product dose omission issue 132.36 16.70 32 73018 247505 79423833
Substance use disorder 130.05 16.70 44 73006 894 79670444
Sepsis 128.96 16.70 43 73007 269385 79401953
Miosis 125.67 16.70 109 72941 15680 79655658
Dizziness 123.52 16.70 182 72868 526259 79145079
Incorrect route of product administration 123.24 16.70 156 72894 34773 79636565
Back pain 122.30 16.70 63 72987 304117 79367221
Depressed level of consciousness 122.05 16.70 272 72778 96380 79574958
Alcoholism 121.25 16.70 62 72988 3661 79667677
Accidental overdose 119.88 16.70 164 72886 39417 79631921
Malaise 118.21 16.70 166 72884 489703 79181635
Pain in extremity 114.95 16.70 99 72951 364439 79306899
Blood ethanol increased 114.06 16.70 37 73013 656 79670682
Arthralgia 113.59 16.70 220 72830 571583 79099755
Pancytopenia 112.09 16.70 11 73039 165734 79505604
White blood cell count decreased 111.73 16.70 19 73031 188269 79483069
Condition aggravated 111.07 16.70 180 72870 500944 79170394
Somnolence 110.76 16.70 473 72577 238508 79432830
Constipation 110.29 16.70 61 72989 282989 79388349
Decreased appetite 107.94 16.70 93 72957 342325 79329013
Haemoglobin decreased 107.06 16.70 35 73015 222084 79449254
Rash 106.01 16.70 233 72817 578125 79093213
Thrombocytopenia 103.58 16.70 57 72993 265202 79406136
Platelet count decreased 98.64 16.70 28 73022 194636 79476702
Unresponsive to stimuli 97.85 16.70 180 72870 55608 79615730
Malignant neoplasm progression 97.52 16.70 7 73043 135983 79535355
Weight decreased 97.49 16.70 109 72941 355089 79316249
Drug screen positive 93.16 16.70 62 72988 6001 79665337
Cerebrovascular accident 91.40 16.70 16 73034 155276 79516062
Fall 89.67 16.70 196 72854 487433 79183905
COVID-19 89.06 16.70 18 73032 157656 79513682
Cardiac failure congestive 87.56 16.70 13 73037 142389 79528949
Metabolic acidosis 87.55 16.70 217 72833 82312 79589026
Environmental exposure 85.06 16.70 26 73024 376 79670962
Dehydration 84.98 16.70 62 72988 248125 79423213
Electrocardiogram QRS complex prolonged 84.63 16.70 74 72976 10759 79660579
Abdominal pain 82.49 16.70 144 72906 389425 79281913
Alcohol withdrawal syndrome 81.90 16.70 39 73011 1972 79669366
Acute kidney injury 81.24 16.70 227 72823 519177 79152161
Pulmonary embolism 81.04 16.70 28 73022 171626 79499712
Loss of consciousness 79.76 16.70 335 72715 167608 79503730
Tachycardia 77.08 16.70 345 72705 177423 79493915
Prescription drug used without a prescription 75.69 16.70 47 73003 4038 79667300
Postmortem blood drug level abnormal 72.64 16.70 26 73024 628 79670710
Erythema 72.34 16.70 59 72991 223231 79448107
Bronchitis 71.56 16.70 16 73034 130628 79540710
Road traffic accident 70.50 16.70 136 72914 43528 79627810
Interstitial lung disease 69.87 16.70 10 73040 112590 79558748
Leukopenia 68.57 16.70 12 73038 116501 79554837
Drug withdrawal syndrome 68.57 16.70 118 72932 34600 79636738
Blood pressure increased 68.28 16.70 56 72994 211304 79460034
Septic shock 67.34 16.70 15 73035 122786 79548552
Neuropathy peripheral 66.78 16.70 23 73027 141282 79530056
Withdrawal syndrome 63.48 16.70 99 72951 26755 79644583
Herpes zoster 63.39 16.70 6 73044 93077 79578261
Influenza 63.17 16.70 20 73030 129586 79541752
Pulmonary oedema 63.01 16.70 201 72849 88053 79583285
Renal impairment 62.88 16.70 33 73017 157750 79513588
Chest pain 61.88 16.70 102 72948 282202 79389136
Irritable bowel syndrome 61.15 16.70 159 72891 62082 79609256
Homicide 60.84 16.70 27 73023 1159 79670179
Suicidal ideation 60.19 16.70 180 72870 76160 79595178
Myocardial infarction 59.20 16.70 49 73001 184080 79487258
Oedema peripheral 58.28 16.70 88 72962 252200 79419138
Intentional product use issue 57.71 16.70 284 72766 151828 79519510
Helicobacter infection 57.48 16.70 167 72883 69537 79601801
Neutrophil count decreased 56.79 16.70 9 73041 93950 79577388
Injection site erythema 56.12 16.70 4 73046 78193 79593145
Injection site pain 55.01 16.70 25 73025 129813 79541525
Shock 54.32 16.70 122 72928 43426 79627912
Muscular weakness 53.90 16.70 41 73009 160688 79510650
Abdominal distension 52.33 16.70 22 73028 119628 79551710
Chemical submission 51.46 16.70 17 73033 320 79671018
C-reactive protein increased 51.39 16.70 27 73023 129000 79542338
Cellulitis 51.10 16.70 18 73032 109042 79562296
Pruritus 50.80 16.70 188 72862 394460 79276878
Chest discomfort 50.54 16.70 32 73018 138012 79533326
Hyponatraemia 50.48 16.70 53 72997 177795 79493543
Victim of chemical submission 50.34 16.70 19 73031 535 79670803
Inappropriate schedule of product administration 50.28 16.70 30 73020 133598 79537740
Haematochezia 49.49 16.70 10 73040 87635 79583703
Gastrooesophageal reflux disease 49.20 16.70 17 73033 104229 79567109
Chills 48.65 16.70 45 73005 160189 79511149
Toxicologic test abnormal 48.25 16.70 24 73026 1336 79670002
Oropharyngeal pain 47.99 16.70 20 73030 109333 79562005
Epistaxis 47.98 16.70 21 73029 111494 79559844
Blood ethanol 47.97 16.70 14 73036 171 79671167
Chronic obstructive pulmonary disease 47.71 16.70 10 73040 85409 79585929
Pleural effusion 47.51 16.70 38 73012 145224 79526114
Victim of sexual abuse 47.45 16.70 18 73032 514 79670824
Psoriasis 47.03 16.70 12 73038 89575 79581763
Dyspnoea exertional 47.00 16.70 11 73039 87062 79584276
Drug reaction with eosinophilia and systemic symptoms 46.94 16.70 3 73047 64241 79607097
Sinus tachycardia 46.70 16.70 104 72946 36804 79634534
Myalgia 46.60 16.70 61 72989 185580 79485758
Dysphagia 46.55 16.70 27 73023 122109 79549229
Sopor 46.33 16.70 97 72953 32913 79638425
Opiates positive 45.62 16.70 21 73029 983 79670355
Alcohol intolerance 45.40 16.70 17 73033 468 79670870
Atrial fibrillation 44.75 16.70 70 72980 197816 79473522
Pulmonary congestion 44.47 16.70 85 72965 27015 79644323
Colitis 44.35 16.70 7 73043 73300 79598038
Cardiac failure 44.11 16.70 46 73004 154796 79516542
Neck pain 43.86 16.70 8 73042 75409 79595929
Electrocardiogram QT prolonged 43.42 16.70 181 72869 90205 79581133
Deep vein thrombosis 42.95 16.70 29 73021 120890 79550448
Sleep disorder due to general medical condition, insomnia type 42.51 16.70 111 72939 43445 79627893
Brain oedema 42.39 16.70 80 72970 25183 79646155
Productive cough 42.39 16.70 14 73036 88317 79583021
Renal failure 41.83 16.70 75 72975 200893 79470445
Loss of personal independence in daily activities 41.54 16.70 21 73029 102559 79568779
Hyperkalaemia 41.22 16.70 27 73023 114371 79556967
Thrombosis 40.94 16.70 13 73037 84087 79587251
Gastrointestinal haemorrhage 40.83 16.70 45 73005 147674 79523664
Rash pruritic 40.80 16.70 8 73042 71621 79599717
Nasal congestion 40.67 16.70 10 73040 76542 79594796
Fluid retention 39.34 16.70 8 73042 69801 79601537
Acidosis 38.80 16.70 67 72983 19695 79651643
Bradypnoea 38.79 16.70 37 73013 6015 79665323
Mucosal inflammation 38.02 16.70 11 73039 75569 79595769
Somnambulism 36.71 16.70 35 73015 5686 79665652
General physical health deterioration 36.12 16.70 130 72920 275108 79396230
Liver injury 35.99 16.70 124 72926 56490 79614848
Amphetamines positive 35.75 16.70 13 73037 329 79671009
Postmortem blood drug level 35.53 16.70 13 73037 335 79671003
Arthritis 35.18 16.70 32 73018 114848 79556490
Therapeutic product effect incomplete 35.07 16.70 47 73003 141598 79529740
Joint swelling 34.86 16.70 141 72909 288505 79382833
Abdominal pain upper 34.77 16.70 98 72952 223721 79447617
Rash maculo-papular 34.74 16.70 5 73045 56073 79615265
Syncope 34.69 16.70 70 72980 179379 79491959
Haemoptysis 34.67 16.70 5 73045 55994 79615344
Seizure 34.49 16.70 293 72757 188541 79482797
Pneumonitis 34.24 16.70 7 73043 60853 79610485
Physical assault 33.61 16.70 20 73030 1591 79669747
Angina pectoris 33.51 16.70 4 73046 51728 79619610
Diabetes mellitus 33.34 16.70 15 73035 78375 79592963
Pupil fixed 33.30 16.70 27 73023 3539 79667799
Amnesia 33.25 16.70 130 72920 62927 79608411
Cataract 33.23 16.70 8 73042 62112 79609226
Angioedema 33.21 16.70 14 73036 76021 79595317
Muscle injury 33.20 16.70 109 72941 48452 79622886
Drug ineffective for unapproved indication 33.10 16.70 4 73046 51234 79620104
Product administration error 32.98 16.70 83 72967 31763 79639575
Acute hepatic failure 32.78 16.70 80 72970 30033 79641305
Hypertension 32.69 16.70 174 72876 330818 79340520
Stress 32.68 16.70 16 73034 79596 79591742
Chronic kidney disease 32.60 16.70 10 73040 66144 79605194
Feeling abnormal 32.60 16.70 60 72990 159139 79512199
Orthostatic hypotension 32.57 16.70 6 73044 56158 79615180
Haemorrhage 32.16 16.70 22 73028 91096 79580242
Cystitis 31.98 16.70 5 73045 52727 79618611
Rectal haemorrhage 31.83 16.70 15 73035 76285 79595053
Drug level increased 31.73 16.70 94 72956 39557 79631781
Product use in unapproved indication 31.70 16.70 120 72930 250239 79421099
Blood pressure fluctuation 31.59 16.70 11 73039 67134 79604204
Aspiration 31.57 16.70 62 72988 20096 79651242
Gastrointestinal toxicity 31.46 16.70 38 73012 8071 79663267
Congestive hepatopathy 31.44 16.70 29 73021 4518 79666820
Therapeutic response decreased 31.37 16.70 11 73039 66842 79604496
Upper respiratory tract infection 30.88 16.70 23 73027 91145 79580193
Substance dependence 30.85 16.70 13 73037 491 79670847
Haematocrit decreased 30.70 16.70 9 73041 61303 79610035
Vision blurred 30.67 16.70 31 73019 105867 79565471
Gait disturbance 30.67 16.70 93 72957 207413 79463925
Cardiac disorder 30.55 16.70 11 73039 65746 79605592
Dry skin 30.54 16.70 12 73038 67983 79603355
Agranulocytosis 30.40 16.70 3 73047 45027 79626311
Self-medication 30.31 16.70 30 73020 5102 79666236
Lymphadenopathy 30.22 16.70 6 73044 53241 79618097
Rhinorrhoea 30.17 16.70 16 73034 76058 79595280
Influenza like illness 30.06 16.70 14 73036 71693 79599645
Toxic epidermal necrolysis 30.02 16.70 3 73047 44578 79626760
Folliculitis 29.88 16.70 115 72935 55265 79616073
Transient ischaemic attack 29.77 16.70 6 73044 52689 79618649
Injection site swelling 29.67 16.70 4 73046 47128 79624210
Skin exfoliation 29.66 16.70 7 73043 55093 79616245
Weight increased 29.56 16.70 142 72908 277244 79394094
Drug eruption 29.47 16.70 3 73047 43932 79627406
Acute myocardial infarction 29.39 16.70 17 73033 77019 79594319
Peripheral swelling 29.33 16.70 137 72913 269480 79401858
Suicidal behaviour 29.09 16.70 24 73026 3223 79668115
Iodine allergy 28.86 16.70 13 73037 578 79670760
Abnormal behaviour 28.82 16.70 86 72964 36335 79635003
Respiratory tract infection 28.67 16.70 5 73045 48684 79622654
Ill-defined disorder 28.63 16.70 128 72922 65747 79605591
Palpitations 28.41 16.70 45 73005 126565 79544773
Clostridium difficile infection 28.41 16.70 3 73047 42682 79628656
Ascites 28.37 16.70 17 73033 75545 79595793
Bone pain 28.25 16.70 8 73042 55734 79615604
Accidental poisoning 28.04 16.70 18 73032 1639 79669699
Cluster headache 27.91 16.70 15 73035 981 79670357
Brain death 27.78 16.70 30 73020 5647 79665691
Fungal infection 27.62 16.70 3 73047 41745 79629593
Dysgeusia 27.54 16.70 9 73041 57168 79614170
Lymphocyte count decreased 27.53 16.70 5 73045 47284 79624054
Myocardial fibrosis 27.44 16.70 18 73032 1700 79669638
Osteoporosis 26.99 16.70 8 73042 54104 79617234
Blood pH decreased 26.83 16.70 27 73023 4684 79666654
Asthma 26.70 16.70 52 72998 135043 79536295
Duodenal ulcer perforation 26.08 16.70 125 72925 66086 79605252
Drug interaction 26.03 16.70 529 72521 414654 79256684
Mobility decreased 25.95 16.70 45 73005 122130 79549208
Exposure via inhalation 25.90 16.70 8 73042 120 79671218
Dysphonia 25.60 16.70 10 73040 56862 79614476
Hypoaesthesia 25.36 16.70 82 72968 179270 79492068
Housebound 24.94 16.70 11 73039 465 79670873
Coma scale abnormal 24.83 16.70 35 73015 8643 79662695
Nasopharyngitis 24.76 16.70 134 72916 253747 79417591
Drug diversion 24.74 16.70 15 73035 1235 79670103
Respiratory acidosis 24.69 16.70 40 73010 11160 79660178
Pain in jaw 24.57 16.70 6 73044 46145 79625193
Infusion related reaction 24.44 16.70 118 72932 230119 79441219
Red blood cell sedimentation rate increased 24.41 16.70 6 73044 45936 79625402
Bezoar 24.36 16.70 20 73030 2668 79668670
Hypothermia 24.31 16.70 60 72990 22686 79648652
Pulmonary hypertension 24.18 16.70 7 73043 48073 79623265
Hepatotoxicity 24.01 16.70 102 72948 51250 79620088
Maternal exposure timing unspecified 23.89 16.70 28 73022 5764 79665574
Accidental exposure to product 23.88 16.70 73 72977 31249 79640089
Blood pressure systolic increased 23.87 16.70 16 73034 66970 79604368
Migraine 23.79 16.70 27 73023 87466 79583872
Hospitalisation 23.60 16.70 31 73019 94205 79577133
Analgesic drug level increased 23.41 16.70 21 73029 3157 79668181
Hepatic fibrosis 23.31 16.70 31 73019 7249 79664089
Blood creatinine increased 23.26 16.70 69 72981 154988 79516350
Delirium tremens 23.19 16.70 12 73038 726 79670612
Cerebral haemorrhage 23.06 16.70 12 73038 57661 79613677
Gun shot wound 23.05 16.70 14 73036 1156 79670182
Hepatitis C virus test positive 23.03 16.70 10 73040 407 79670931
Hepatic failure 22.98 16.70 114 72936 61098 79610240
Red blood cell count decreased 22.94 16.70 12 73038 57501 79613837
Protein C increased 22.73 16.70 7 73043 104 79671234
Presyncope 22.53 16.70 5 73045 41049 79630289
Throat irritation 22.44 16.70 5 73045 40941 79630397
Hypothyroidism 22.32 16.70 10 73040 52382 79618956
Impaired driving ability 22.04 16.70 26 73024 5389 79665949
Euphoric mood 21.87 16.70 31 73019 7695 79663643
Rash erythematous 21.68 16.70 13 73037 57756 79613582
Nephrolithiasis 21.44 16.70 11 73039 53280 79618058
Urticaria 21.39 16.70 92 72958 185109 79486229
Dysarthria 21.32 16.70 120 72930 67502 79603836
Haematuria 21.28 16.70 19 73031 68817 79602521
Blood glucose increased 21.24 16.70 46 73004 114929 79556409
Illness 21.23 16.70 8 73042 46503 79624835
Melaena 21.09 16.70 15 73035 60875 79610463
Hot flush 21.09 16.70 12 73038 54865 79616473
Breast cancer 20.95 16.70 3 73047 33778 79637560
Muscle spasms 20.68 16.70 86 72964 174644 79496694
Haematoma 20.66 16.70 11 73039 52184 79619154
Balance disorder 20.46 16.70 37 73013 98820 79572518
Viral infection 20.32 16.70 7 73043 43009 79628329
Visceral congestion 20.29 16.70 12 73038 944 79670394
Candida infection 20.28 16.70 5 73045 38209 79633129
Compartment syndrome 20.02 16.70 24 73026 5058 79666280
Brain injury 19.98 16.70 37 73013 11480 79659858
Swollen tongue 19.98 16.70 7 73043 42563 79628775
Electrocardiogram ST segment elevation 19.90 16.70 31 73019 8366 79662972
Alcoholic liver disease 19.82 16.70 10 73040 574 79670764
Gastric disorder 19.67 16.70 5 73045 37428 79633910
Dyspepsia 19.65 16.70 44 73006 108643 79562695
Sudden death 19.59 16.70 55 72995 22456 79648882
Disease recurrence 19.46 16.70 8 73042 44101 79627237
Hepatitis alcoholic 19.25 16.70 10 73040 610 79670728
Pericarditis 19.15 16.70 162 72888 104074 79567264
Vertigo 19.13 16.70 21 73029 69061 79602277
Hypocalcaemia 19.07 16.70 11 73039 49913 79621425
Therapy interrupted 18.94 16.70 3 73047 31338 79640000
Paraesthesia 18.92 16.70 90 72960 176233 79495105
Skin disorder 18.90 16.70 4 73046 33939 79637399
Gastric ulcer 18.87 16.70 4 73046 33901 79637437
Eczema 18.67 16.70 7 73043 40811 79630527
Anaphylactic reaction 18.56 16.70 30 73020 83713 79587625
Induced abortion failed 18.48 16.70 7 73043 199 79671139
Respiratory failure 18.46 16.70 94 72956 180817 79490521
Neuralgia 18.45 16.70 4 73046 33380 79637958
Product prescribing error 18.40 16.70 9 73041 44804 79626534
Sleep disorder 18.39 16.70 138 72912 85539 79585799
Areflexia 18.39 16.70 24 73026 5510 79665828
Alcoholic 18.32 16.70 5 73045 47 79671291
Visceral oedema 18.26 16.70 6 73044 111 79671227
Ischaemic stroke 18.25 16.70 4 73046 33127 79638211
Pulmonary toxicity 18.18 16.70 38 73012 12876 79658462
Conjunctival scar 18.13 16.70 7 73043 210 79671128
Multiple injuries 18.04 16.70 19 73031 3476 79667862
Blood pressure diastolic decreased 18.02 16.70 3 73047 30213 79641125
Blood methanol increased 17.99 16.70 3 73047 0 79671338
Localised infection 17.95 16.70 6 73044 37569 79633769
Substance-induced mood disorder 17.87 16.70 6 73044 119 79671219
Behavioural addiction 17.61 16.70 5 73045 55 79671283
Hip arthroplasty 17.47 16.70 72 72978 35684 79635654
Behaviour disorder 17.38 16.70 25 73025 6288 79665050
Blood lactic acid increased 17.36 16.70 37 73013 12707 79658631
Burning sensation 17.16 16.70 17 73033 58615 79612723
Fatty liver alcoholic 17.06 16.70 5 73045 62 79671276
Coronary artery disease 16.95 16.70 21 73029 65453 79605885
Hypervolaemia 16.89 16.70 9 73041 42681 79628657
Electrocardiogram repolarisation abnormality 16.74 16.70 15 73035 2252 79669086
Altered state of consciousness 16.73 16.70 82 72968 43740 79627598

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC D08AX08 DERMATOLOGICALS
ANTISEPTICS AND DISINFECTANTS
ANTISEPTICS AND DISINFECTANTS
Other antiseptics and disinfectants
ATC V03AB16 VARIOUS
ALL OTHER THERAPEUTIC PRODUCTS
ALL OTHER THERAPEUTIC PRODUCTS
Antidotes
ATC V03AZ01 VARIOUS
ALL OTHER THERAPEUTIC PRODUCTS
ALL OTHER THERAPEUTIC PRODUCTS
Nerve depressants
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000891 Anti-Infective Agents, Local
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D012997 Solvents
CHEBI has role CHEBI:35488 central nervous system depressants
CHEBI has role CHEBI:48218 antiseptics
CHEBI has role CHEBI:48219 disinfectants
CHEBI has role CHEBI:48354 polar solvent
CHEBI has role CHEBI:50905 teratogeno
CHEBI has role CHEBI:50910 agente neurotoxico
CHEBI has role CHEBI:60643 N-methyl-D-aspartate receptor antagonists
CHEBI has role CHEBI:64018 protein kinase C agonists
CHEBI has role CHEBI:75771 Mus musculus metabolites
CHEBI has role CHEBI:75772 S. cerevisiae metabolites
CHEBI has role CHEBI:76971 Escherichia coli metabolites
CHEBI has role CHEBI:77746 Homo sapiens metabolite

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Antiseptic preparation indication 261276004




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
99% (1ML) ABLYSINOL BPI LABS N207987 June 21, 2018 RX SOLUTION INTRA-ARTERIAL June 21, 2025 INDICATED TO INDUCE CONTROLLED CARDIAC SEPTAL INFRACTION TO IMPROVE EXERCISE CAPACITY IN ADULTS WITH SYMPTOMATIC HYPERTROPHIC OBSTRUCTIVE CARDIOMYOPATHY WHO ARE NOT CANDIDATES FOR SURGICAL MYECTOMY
99% (5ML) ABLYSINOL BPI LABS N207987 June 21, 2018 RX SOLUTION INTRA-ARTERIAL June 21, 2025 INDICATED TO INDUCE CONTROLLED CARDIAC SEPTAL INFRACTION TO IMPROVE EXERCISE CAPACITY IN ADULTS WITH SYMPTOMATIC HYPERTROPHIC OBSTRUCTIVE CARDIOMYOPATHY WHO ARE NOT CANDIDATES FOR SURGICAL MYECTOMY

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Glycine receptor subunit alpha-1 Ion channel WOMBAT-PK
Glycine receptor subunit alpha-2 Ion channel WOMBAT-PK
Glutamate receptor ionotropic, NMDA 3A Ion channel WOMBAT-PK
GABA A receptor alpha-4/beta-2/delta Ion channel WOMBAT-PK

External reference:

IDSource
4017736 VUID
N0000146104 NUI
D06542 KEGG_DRUG
4017424 VANDF
4017736 VANDF
C0001962 UMLSCUI
CHEBI:16236 CHEBI
EOH PDB_CHEM_ID
CHEMBL545 ChEMBL_ID
702 PUBCHEM_CID
DB00898 DRUGBANK_ID
D000431 MESH_DESCRIPTOR_UI
2299 IUPHAR_LIGAND_ID
448 RXNORM
10010 MMSL
4693 MMSL
9888 MMSL
d03162 MMSL
001539 NDDF
002464 NDDF
398624005 SNOMEDCT_US
419442005 SNOMEDCT_US
3K9958V90M UNII

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
TRISEPTINHAND AND BODY ANTISEPTIC HUMAN OTC DRUG LABEL 1 0064-1050 LOTION 0.70 mL TOPICAL OTC monograph not final 9 sections
SURGICEPT Waterless, Surgical Handscrub and Healthcare Personnel Handwash HUMAN OTC DRUG LABEL 1 0064-1080 SOLUTION 0.75 mL TOPICAL OTC monograph not final 10 sections
hand sanitizer HUMAN OTC DRUG LABEL 1 0113-7077 GEL 70 mL TOPICAL OTC monograph not final 12 sections
Humphreys Alcoholado Maravilla HUMAN OTC DRUG LABEL 1 0219-2020 LIQUID 70 mL TOPICAL OTC MONOGRAPH NOT FINAL 13 sections
Nozin Nasal Sanitizer HUMAN OTC DRUG LABEL 1 0295-9025 LIQUID 62 mL TOPICAL OTC monograph not final 9 sections
Keri Clinical Care Hand Sanitizing Gel - HEALTHCARE HUMAN OTC DRUG LABEL 1 0316-0214 GEL 0.70 mL TOPICAL OTC monograph not final 11 sections
Keri Clinical Care Hand Sanitizing Gel HUMAN OTC DRUG LABEL 1 0316-0292 GEL 0.70 mL TOPICAL OTC monograph not final 11 sections
SeptoSan Hand Sanitizer HUMAN OTC DRUG LABEL 1 0362-6000 LIQUID 60 L TOPICAL OTC MONOGRAPH NOT FINAL 14 sections
SeptoSan Hand Sanitizer HUMAN OTC DRUG LABEL 1 0362-6001 LIQUID 60 L TOPICAL OTC MONOGRAPH NOT FINAL 14 sections
SeptoSan Hand Sanitizer HUMAN OTC DRUG LABEL 1 0362-6002 LIQUID 60 L TOPICAL OTC MONOGRAPH NOT FINAL 14 sections
Alcohol HUMAN OTC DRUG LABEL 1 0363-0046 LIQUID 62 mg TOPICAL OTC monograph not final 12 sections
Alcohol HUMAN OTC DRUG LABEL 1 0363-0046 LIQUID 62 mg TOPICAL OTC monograph not final 12 sections
Alcohol HUMAN OTC DRUG LABEL 1 0363-0046 LIQUID 62 mL TOPICAL OTC monograph not final 12 sections
Iodine HUMAN OTC DRUG LABEL 3 0363-0088 LIQUID 470 mg TOPICAL OTC monograph not final 12 sections
Advanced Hand Sanitizer HUMAN OTC DRUG LABEL 1 0363-0370 GEL 70 mL TOPICAL OTC monograph not final 12 sections
Advanced Hand Sanitizer HUMAN OTC DRUG LABEL 1 0363-0370 GEL 70 mL TOPICAL OTC monograph not final 12 sections
Hand Sanitizer HUMAN OTC DRUG LABEL 1 0363-0469 GEL 545 mg TOPICAL OTC monograph not final 12 sections
Hand Sanitizer HUMAN OTC DRUG LABEL 1 0363-0469 GEL 545 mg TOPICAL OTC monograph not final 12 sections
Hand Sanitizer HUMAN OTC DRUG LABEL 1 0363-0596 GEL 63 mL TOPICAL OTC monograph not final 12 sections
Hand Sanitizer HUMAN OTC DRUG LABEL 1 0363-0596 GEL 567 mg TOPICAL OTC monograph not final 12 sections
Hand Sanitizer HUMAN OTC DRUG LABEL 1 0363-0643 GEL 558 mg TOPICAL OTC monograph not final 11 sections
Hand Sanitizer HUMAN OTC DRUG LABEL 1 0363-0643 GEL 558 mg TOPICAL OTC monograph not final 11 sections
Crisp Apple Hand Sani HUMAN OTC DRUG LABEL 1 0363-0663 LIQUID 585 g TOPICAL OTC monograph not final 13 sections
Walgreens HUMAN OTC DRUG LABEL 1 0363-0859 GEL 700 mg TOPICAL OTC monograph not final 12 sections
Ethyl Rubbing Alcohol HUMAN OTC DRUG LABEL 1 0363-0876 LIQUID 610 mg TOPICAL OTC monograph not final 13 sections
Ethyl Rubbing Alcohol HUMAN OTC DRUG LABEL 1 0363-0876 LIQUID 70 mL TOPICAL OTC monograph not final 13 sections
Ethyl Rubbing Alcohol HUMAN OTC DRUG LABEL 1 0363-0876 LIQUID 610 mg TOPICAL OTC monograph not final 13 sections
Hand Sanitizer HUMAN OTC DRUG LABEL 1 0363-0890 GEL 567 mg TOPICAL OTC monograph not final 11 sections
Hand Sanitizer HUMAN OTC DRUG LABEL 1 0363-0890 GEL 567 mg TOPICAL OTC monograph not final 11 sections
Hand Sanitizer HUMAN OTC DRUG LABEL 1 0363-0898 GEL 567 mg TOPICAL OTC monograph not final 11 sections