ethanol ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
1076 64-17-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • alcohol
  • ethanol
  • ethyl alcohol
  • grain alcohol
A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in ALCOHOLIC BEVERAGES.
  • Molecular weight: 46.07
  • Formula: C2H6O
  • CLOGP: -0.24
  • LIPINSKI: 0
  • HAC: 1
  • HDO: 1
  • TPSA: 20.23
  • ALOGS: 1.10
  • ROTB: 0

Drug dosage:

None

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 2.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 2170.63 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 80 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
Jan. 17, 1946 FDA B BRAUN

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 8618.35 19.03 3220 30457 128669 50442778
Toxicity to various agents 4813.21 19.03 2468 31209 210031 50361416
Drug abuse 3057.26 19.03 1232 32445 58614 50512833
Cardio-respiratory arrest 1785.01 19.03 818 32859 53074 50518373
Intentional overdose 1459.44 19.03 747 32930 61757 50509690
Respiratory arrest 1149.78 19.03 505 33172 29504 50541943
Overdose 1100.65 19.03 733 32944 98994 50472453
Cardiac arrest 872.28 19.03 594 33083 83057 50488390
Poisoning 826.63 19.03 311 33366 12118 50559329
Suicide attempt 806.31 19.03 474 33203 51258 50520189
Intentional product misuse 735.53 19.03 431 33246 46303 50525144
Death 610.08 19.03 903 32774 324476 50246971
Alcohol interaction 526.82 19.03 145 33532 1999 50569448
Drug hypersensitivity 496.18 19.03 715 32962 250295 50321152
Alcohol poisoning 429.64 19.03 119 33558 1681 50569766
Alcohol use 422.03 19.03 120 33557 1875 50569572
Exposure via ingestion 340.51 19.03 110 33567 2693 50568754
Suspected suicide 330.57 19.03 127 33550 5230 50566217
Alcohol abuse 257.26 19.03 81 33596 1820 50569627
Coma 247.31 19.03 243 33434 56636 50514811
Poisoning deliberate 199.80 19.03 100 33577 7812 50563635
Diarrhoea 170.64 19.03 90 33587 588386 49983061
Somnolence 163.59 19.03 335 33342 154650 50416797
Blood alcohol increased 159.21 19.03 43 33634 549 50570898
Headache 127.83 19.03 91 33586 506444 50065003
Drug ineffective 124.44 19.03 223 33454 819110 49752337
Fatigue 122.00 19.03 177 33500 707424 49864023
Mydriasis 118.80 19.03 79 33598 10548 50560899
Methaemoglobinaemia 117.40 19.03 46 33631 1996 50569451
Pneumonia 115.26 19.03 54 33623 378347 50193100
Exposure to toxic agent 106.62 19.03 51 33626 3607 50567840
Nausea 104.25 19.03 195 33482 705203 49866244
Off label use 100.30 19.03 101 33576 474325 50097122
Asthenia 99.49 19.03 44 33633 318998 50252449
Intentional self-injury 95.28 19.03 96 33581 23016 50548431
Pain 94.59 19.03 150 33527 578753 49992694
Substance abuse 92.13 19.03 48 33629 4076 50567371
Dyspnoea 91.25 19.03 140 33537 547468 50023979
Agitation 86.31 19.03 139 33538 53245 50518202
Alcoholism 84.43 19.03 34 33643 1586 50569861
Cough 83.92 19.03 28 33649 241236 50330211
Loss of consciousness 83.39 19.03 202 33475 104151 50467296
Anaemia 79.95 19.03 34 33643 252422 50319025
Product dose omission issue 78.17 19.03 14 33663 183824 50387623
Malaise 73.62 19.03 69 33608 335463 50235984
Back pain 70.68 19.03 29 33648 220001 50351446
Postmortem blood drug level abnormal 68.85 19.03 20 33657 338 50571109
Drug dependence 68.79 19.03 75 33602 19684 50551763
Pyrexia 67.32 19.03 93 33584 380110 50191337
Drug abuser 66.29 19.03 34 33643 2794 50568653
Urinary tract infection 65.02 19.03 34 33643 223986 50347461
Rash 64.33 19.03 121 33556 437350 50134097
Unresponsive to stimuli 64.16 19.03 90 33587 30519 50540928
Metabolic acidosis 63.99 19.03 102 33575 38723 50532724
Accidental death 62.30 19.03 28 33649 1716 50569731
Neutropenia 61.32 19.03 12 33665 147953 50423494
Tachycardia 61.18 19.03 175 33502 99588 50471859
Dizziness 61.02 19.03 85 33592 346284 50225163
Drug use disorder 60.85 19.03 33 33644 3039 50568408
Depressed level of consciousness 59.09 19.03 116 33561 51837 50519610
Aggression 56.50 19.03 70 33607 21046 50550401
Gastrointestinal toxicity 55.26 19.03 36 33641 4641 50566806
Liver injury 55.08 19.03 75 33602 24731 50546716
Victim of sexual abuse 53.44 19.03 18 33659 503 50570944
Blood ethanol increased 53.39 19.03 13 33664 106 50571341
Hepatic failure 52.08 19.03 84 33593 32199 50539248
Decreased appetite 51.95 19.03 35 33642 200888 50370559
Disease progression 51.68 19.03 3 33674 95863 50475584
Constipation 51.24 19.03 30 33647 185678 50385769
Electrocardiogram QT prolonged 50.91 19.03 109 33568 51777 50519670
Electrocardiogram QRS complex prolonged 50.90 19.03 36 33641 5308 50566139
Weight decreased 49.05 19.03 45 33632 221200 50350247
Bronchitis 48.69 19.03 6 33671 104153 50467294
Drug withdrawal syndrome 48.53 19.03 71 33606 25010 50546437
Pain in extremity 47.98 19.03 67 33610 272798 50298649
Pulmonary toxicity 47.35 19.03 35 33642 5527 50565920
Irritable bowel syndrome 45.87 19.03 104 33573 51337 50520110
Seizure 45.63 19.03 177 33500 117697 50453750
White blood cell count decreased 45.24 19.03 11 33666 116711 50454736
Febrile neutropenia 44.75 19.03 6 33671 97661 50473786
Fall 44.60 19.03 98 33579 334834 50236613
Haemoglobin decreased 43.77 19.03 15 33662 127201 50444246
Sepsis 43.50 19.03 17 33660 132908 50438539
Arthralgia 43.03 19.03 149 33528 438553 50132894
Cerebrovascular accident 42.95 19.03 6 33671 94674 50476773
Thrombocytopenia 42.32 19.03 16 33661 127657 50443790
Cardiac failure congestive 41.63 19.03 4 33673 84378 50487069
Asphyxia 41.43 19.03 32 33645 5395 50566052
Arthritis 40.52 19.03 5 33672 86716 50484731
Myocarditis 40.28 19.03 37 33640 7910 50563537
Influenza 39.86 19.03 6 33671 89532 50481915
Suicidal ideation 39.77 19.03 103 33574 55282 50516165
Sinus tachycardia 39.23 19.03 59 33618 21295 50550152
Abdominal pain 38.60 19.03 61 33616 236167 50335280
Somnambulism 37.52 19.03 29 33648 4895 50566552
Hepatotoxicity 37.47 19.03 66 33611 27160 50544287
Blood pressure increased 37.43 19.03 21 33656 133111 50438336
Respiratory depression 37.37 19.03 43 33634 11967 50559480
Condition aggravated 37.04 19.03 90 33587 296968 50274479
Chest pain 36.84 19.03 38 33639 176844 50394603
Pancytopenia 36.57 19.03 6 33671 84024 50487423
Accidental overdose 35.93 19.03 54 33623 19479 50551968
Injection site pain 35.02 19.03 15 33662 111009 50460438
Dehydration 34.98 19.03 30 33647 152419 50419028
Muscular weakness 34.83 19.03 10 33667 95003 50476444
Homicide 34.82 19.03 12 33665 360 50571087
Iodine allergy 34.09 19.03 14 33663 687 50570760
Neuropathy peripheral 34.00 19.03 11 33666 96746 50474701
Chemical submission 33.83 19.03 10 33667 180 50571267
Erythema 33.36 19.03 29 33648 146385 50425062
Pulmonary embolism 33.28 19.03 13 33664 101691 50469756
Loss of personal independence in daily activities 32.82 19.03 4 33673 70046 50501401
Drug screen positive 32.59 19.03 23 33654 3379 50568068
Psoriasis 32.18 19.03 4 33673 68996 50502451
Housebound 32.12 19.03 10 33667 216 50571231
Mobility decreased 32.04 19.03 7 33670 79941 50491506
Aspiration 31.95 19.03 35 33642 9229 50562218
Injection site erythema 31.19 19.03 6 33671 74930 50496517
Platelet count decreased 31.15 19.03 14 33663 100712 50470735
Herpes zoster 30.92 19.03 5 33672 70781 50500666
Oedema peripheral 30.62 19.03 36 33641 157925 50413522
Abdominal pain upper 30.14 19.03 37 33640 159272 50412175
Acute hepatic failure 29.78 19.03 44 33633 15633 50555814
Malignant neoplasm progression 29.34 19.03 5 33672 68119 50503328
Protein C increased 29.00 19.03 8 33669 111 50571336
Leukopenia 28.98 19.03 5 33672 67523 50503924
Disinhibition 28.92 19.03 13 33664 797 50570650
Medication error 28.91 19.03 70 33607 36034 50535413
Oropharyngeal pain 28.86 19.03 8 33669 77793 50493654
Muscle injury 28.71 19.03 71 33606 37040 50534407
Sopor 28.41 19.03 49 33628 19830 50551617
Gastrooesophageal reflux disease 28.09 19.03 8 33669 76420 50495027
Drug interaction 27.60 19.03 227 33450 199394 50372053
Environmental exposure 27.56 19.03 7 33670 69 50571378
Ill-defined disorder 27.05 19.03 89 33588 54565 50516882
Ventricular tachycardia 26.65 19.03 42 33635 15779 50555668
Victim of chemical submission 26.64 19.03 9 33668 254 50571193
Helicobacter infection 26.48 19.03 83 33594 49619 50521828
C-reactive protein increased 26.27 19.03 6 33671 66468 50504979
Osteoarthritis 25.55 19.03 7 33670 68599 50502848
Brain oedema 25.36 19.03 36 33641 12334 50559113
Weight increased 25.27 19.03 61 33616 201830 50369617
Septic shock 25.06 19.03 4 33673 57171 50514276
Pulmonary congestion 25.03 19.03 40 33637 15207 50556240
Muscle spasms 24.99 19.03 28 33649 125525 50445922
Substance dependence 24.75 19.03 8 33669 196 50571251
Folliculitis 24.20 19.03 69 33608 39156 50532291
Incorrect route of product administration 24.09 19.03 44 33633 18622 50552825
Upper respiratory tract infection 24.03 19.03 7 33670 65891 50505556
Migraine 24.01 19.03 10 33667 75270 50496177
Miosis 23.81 19.03 25 33652 6285 50565162
Induced abortion failed 23.64 19.03 8 33669 227 50571220
Alcohol withdrawal syndrome 23.62 19.03 11 33666 732 50570715
Sinusitis 23.41 19.03 49 33628 170509 50400938
Shock 23.33 19.03 46 33631 20604 50550843
Neck pain 22.86 19.03 5 33672 57062 50514385
Areflexia 22.56 19.03 17 33660 2763 50568684
Brain death 22.54 19.03 17 33660 2766 50568681
Abnormal behaviour 22.47 19.03 44 33633 19614 50551833
Palpitations 22.40 19.03 18 33659 94488 50476959
Blood pH decreased 22.14 19.03 16 33661 2439 50569008
Wheezing 21.89 19.03 7 33670 62040 50509407
Cardiogenic shock 21.70 19.03 38 33639 15561 50555886
Visceral congestion 21.42 19.03 8 33669 304 50571143
Therapeutic response decreased 21.40 19.03 3 33674 47228 50524219
Congenital umbilical hernia 21.40 19.03 8 33669 305 50571142
Acidosis 21.32 19.03 30 33647 10197 50561250
Acute kidney injury 21.27 19.03 79 33598 227979 50343468
Epistaxis 21.21 19.03 8 33669 63946 50507501
Asthma 21.20 19.03 17 33660 89320 50482127
Blood lactic acid increased 20.84 19.03 22 33655 5563 50565884
Euphoric mood 20.79 19.03 19 33658 4036 50567411
Hyponatraemia 20.75 19.03 20 33657 96119 50475328
Gait disturbance 20.66 19.03 43 33634 149962 50421485
Alcoholic 20.62 19.03 5 33672 40 50571407
Myalgia 20.38 19.03 32 33645 124287 50447160
Postmortem blood drug level 20.25 19.03 6 33671 109 50571338
Amnesia 20.19 19.03 68 33609 42192 50529255
Hypotension 19.98 19.03 242 33435 235227 50336220
Abdominal distension 19.77 19.03 12 33665 72891 50498556
Rhinorrhoea 19.71 19.03 5 33672 51578 50519869
Hypoaesthesia 19.70 19.03 34 33643 127223 50444224
Analgesic drug level increased 19.66 19.03 13 33664 1718 50569729
Rheumatoid arthritis 19.65 19.03 69 33608 202481 50368966
Nasal congestion 19.45 19.03 5 33672 51115 50520332
Influenza like illness 19.37 19.03 7 33670 57452 50513995
Ventricular fibrillation 19.14 19.03 29 33648 10530 50560917
Toxicologic test abnormal 19.12 19.03 9 33668 614 50570833

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug abuse 7508.60 20.46 2896 28879 76987 29465765
Completed suicide 6373.27 20.46 2666 29109 87580 29455172
Toxicity to various agents 5278.20 20.46 2870 28905 170791 29371961
Cardio-respiratory arrest 1485.26 20.46 826 30949 49775 29492977
Intentional product misuse 1152.14 20.46 615 31160 34046 29508706
Intentional overdose 1104.77 20.46 620 31155 37908 29504844
Poisoning 948.97 20.46 369 31406 9624 29533128
Respiratory arrest 922.03 20.46 481 31294 25352 29517400
Overdose 899.82 20.46 718 31057 79101 29463651
Alcohol abuse 633.62 20.46 220 31555 4113 29538639
Cardiac arrest 578.35 20.46 577 31198 85014 29457738
Suicide attempt 568.52 20.46 389 31386 33721 29509031
Alcohol interaction 508.94 20.46 166 31609 2537 29540215
Exposure via ingestion 471.12 20.46 146 31629 1872 29540880
Alcohol poisoning 463.80 20.46 160 31615 2929 29539823
Substance abuse 398.46 20.46 178 31597 6609 29536143
Death 387.21 20.46 1012 30763 341072 29201680
Drug dependence 348.58 20.46 239 31536 20742 29522010
Suspected suicide 317.15 20.46 130 31645 3890 29538862
Alcohol use 312.47 20.46 120 31655 3012 29539740
Coma 254.74 20.46 260 31515 39190 29503562
Poisoning deliberate 233.86 20.46 117 31658 5614 29537138
Asphyxia 233.20 20.46 114 31661 5201 29537551
Blood alcohol increased 201.08 20.46 60 31715 670 29542082
Diarrhoea 197.24 20.46 57 31718 332641 29210111
Pneumonia 189.49 20.46 55 31720 320117 29222635
Aggression 176.46 20.46 204 31571 35337 29507415
Respiratory depression 176.24 20.46 133 31642 13390 29529362
Drug ineffective 171.09 20.46 89 31686 363081 29179671
Anaemia 164.25 20.46 14 31761 200937 29341815
Pyrexia 163.62 20.46 53 31722 287569 29255183
Dyspnoea 148.05 20.46 84 31691 326648 29216104
Accidental death 141.94 20.46 61 31714 2057 29540695
Fatigue 137.11 20.46 86 31689 316735 29226017
Accidental overdose 115.33 20.46 117 31658 17476 29525276
Exposure to toxic agent 115.24 20.46 56 31719 2519 29540233
Off label use 115.18 20.46 93 31682 300707 29242045
Rash 115.02 20.46 31 31744 189788 29352964
Incorrect route of product administration 106.06 20.46 90 31685 10711 29532041
Neutropenia 105.29 20.46 10 31765 131701 29411051
Intentional self-injury 91.18 20.46 88 31687 12373 29530379
Sepsis 90.83 20.46 21 31754 142661 29400091
Drug withdrawal syndrome 90.48 20.46 104 31671 17880 29524872
Alcohol withdrawal syndrome 90.21 20.46 39 31736 1334 29541418
Arthralgia 89.97 20.46 20 31755 139597 29403155
Nausea 88.22 20.46 109 31666 289146 29253606
Intentional product use issue 86.50 20.46 160 31615 42338 29500414
Cough 86.13 20.46 16 31759 126711 29416041
Asthenia 84.21 20.46 65 31710 215185 29327567
Drug abuser 84.09 20.46 52 31723 3775 29538977
Febrile neutropenia 83.44 20.46 11 31764 112229 29430523
Drug screen positive 81.88 20.46 51 31724 3750 29539002
Alcoholism 79.17 20.46 44 31731 2617 29540135
Miosis 77.12 20.46 66 31709 7943 29534809
Pain in extremity 77.08 20.46 13 31762 110420 29432332
Suicidal ideation 71.00 20.46 131 31644 34585 29508167
Pruritus 70.85 20.46 19 31756 116830 29425922
Agitation 69.03 20.46 163 31612 51141 29491611
Drug use disorder 68.92 20.46 44 31731 3378 29539374
Product dose omission issue 68.03 20.46 11 31764 96372 29446380
Malignant neoplasm progression 66.62 20.46 3 31772 73856 29468896
Back pain 65.16 20.46 15 31760 102269 29440483
Haemoglobin decreased 64.99 20.46 18 31757 108357 29434395
Medication error 64.93 20.46 96 31679 21115 29521637
Decreased appetite 64.67 20.46 38 31737 145304 29397448
Pain 62.98 20.46 55 31720 171377 29371375
White blood cell count decreased 62.35 20.46 8 31767 83354 29459398
Pancytopenia 62.16 20.46 8 31767 83160 29459592
Unresponsive to stimuli 62.01 20.46 103 31672 25023 29517729
Platelet count decreased 61.62 20.46 18 31757 104654 29438098
Environmental exposure 60.96 20.46 19 31756 248 29542504
Oedema peripheral 60.61 20.46 18 31757 103539 29439213
Dizziness 58.21 20.46 71 31704 189613 29353139
Withdrawal syndrome 57.71 20.46 65 31710 10927 29531825
Thrombocytopenia 57.54 20.46 37 31738 134786 29407966
Alcohol intolerance 57.49 20.46 20 31755 375 29542377
Condition aggravated 57.36 20.46 44 31731 146251 29396501
Mydriasis 56.26 20.46 49 31726 6036 29536716
Road traffic accident 55.85 20.46 76 31699 15485 29527267
Sopor 54.60 20.46 63 31712 10871 29531881
Infection 53.61 20.46 9 31766 76742 29466010
Pulmonary oedema 53.43 20.46 132 31643 42603 29500149
Blood ethanol increased 53.24 20.46 20 31755 471 29542281
Depressed level of consciousness 52.56 20.46 120 31655 36822 29505930
Cardiac failure congestive 51.29 20.46 10 31765 76571 29466181
Atrial fibrillation 47.85 20.46 27 31748 105619 29437133
Cerebrovascular accident 47.56 20.46 12 31763 76899 29465853
Headache 46.46 20.46 72 31703 173935 29368817
Nasopharyngitis 46.40 20.46 5 31770 59660 29483092
Renal impairment 46.03 20.46 15 31760 81318 29461434
Cardiac failure 45.99 20.46 14 31761 79273 29463479
Shock 45.30 20.46 82 31693 21322 29521430
General physical health deterioration 44.18 20.46 28 31747 102829 29439923
Neuropathy peripheral 44.07 20.46 11 31764 71016 29471736
Ex-drug abuser 43.90 20.46 13 31762 141 29542611
Pulmonary embolism 43.52 20.46 14 31761 76520 29466232
Myocardial infarction 43.43 20.46 33 31742 110263 29432489
Methaemoglobinaemia 43.29 20.46 30 31745 2641 29540111
Abdominal pain 43.27 20.46 49 31726 135308 29407444
Dehydration 43.09 20.46 36 31739 114712 29428040
Pleural effusion 42.98 20.46 12 31763 71896 29470856
Chest pain 42.21 20.46 35 31740 111938 29430814
Deep vein thrombosis 41.74 20.46 6 31769 57393 29485359
Joint swelling 41.73 20.46 3 31772 49627 29493125
Weight decreased 41.66 20.46 61 31714 150844 29391908
Constipation 41.43 20.46 37 31738 114123 29428629
Peripheral swelling 41.27 20.46 9 31766 63730 29479022
Acute kidney injury 40.98 20.46 147 31628 265120 29277632
Homicide 40.98 20.46 20 31755 908 29541844
Physical assault 40.91 20.46 21 31754 1063 29541689
Metabolic acidosis 40.55 20.46 110 31665 37552 29505200
Drug intolerance 40.46 20.46 3 31772 48376 29494376
Somnolence 39.93 20.46 203 31572 93752 29449000
Urinary tract infection 39.80 20.46 14 31761 72340 29470412
Muscular weakness 39.70 20.46 9 31766 62043 29480709
Amnesia 38.42 20.46 79 31696 22564 29520188
Malaise 38.03 20.46 71 31704 159531 29383221
Hepatic fibrosis 38.01 20.46 30 31745 3222 29539530
Drug interaction 37.22 20.46 349 31426 197036 29345716
Urticaria 36.88 20.46 7 31768 54653 29488099
Self-medication 36.82 20.46 25 31750 2129 29540623
Loss of consciousness 36.50 20.46 167 31608 73889 29468863
Septic shock 36.36 20.46 11 31764 62549 29480203
Erythema 36.17 20.46 18 31757 75588 29467164
Infusion related reaction 35.92 20.46 3 31772 43883 29498869
Cluster headache 35.89 20.46 15 31760 471 29542281
Neutrophil count decreased 35.60 20.46 3 31772 43564 29499188
Weight increased 35.57 20.46 19 31756 76648 29466104
Chills 34.07 20.46 17 31758 71283 29471469
Tachycardia 34.00 20.46 161 31614 72249 29470503
Suicidal behaviour 33.73 20.46 20 31755 1345 29541407
Chronic obstructive pulmonary disease 32.97 20.46 3 31772 40952 29501800
Product use in unapproved indication 32.92 20.46 27 31748 86848 29455904
Thrombosis 32.49 20.46 4 31771 43041 29499711
Gun shot wound 32.44 20.46 18 31757 1067 29541685
Myalgia 31.98 20.46 20 31755 73999 29468753
Abnormal behaviour 31.64 20.46 74 31701 23053 29519699
Toxicologic test abnormal 31.33 20.46 14 31761 519 29542233
Dysphagia 31.30 20.46 10 31765 54916 29487836
Renal failure 30.74 20.46 50 31725 118549 29424203
Impaired driving ability 30.51 20.46 23 31752 2308 29540444
Dysarthria 30.04 20.46 87 31688 30824 29511928
Exposure via inhalation 29.83 20.46 7 31768 27 29542725
Leukopenia 29.81 20.46 11 31764 55192 29487560
Stomatitis 29.13 20.46 3 31772 37110 29505642
Haematochezia 29.01 20.46 3 31772 36980 29505772
Hospitalisation 28.76 20.46 7 31768 45981 29496771
Chest discomfort 28.75 20.46 7 31768 45976 29496776
Dyspnoea exertional 28.52 20.46 3 31772 36487 29506265
Pulmonary congestion 28.06 20.46 49 31726 12387 29530365
COVID-19 28.04 20.46 3 31772 36011 29506741
Foetal alcohol syndrome 27.67 20.46 9 31766 136 29542616
Influenza 26.93 20.46 6 31769 41875 29500877
Prescription drug used without a prescription 26.84 20.46 17 31758 1287 29541465
Brain oedema 26.09 20.46 47 31728 12173 29530579
Chronic kidney disease 26.02 20.46 4 31771 36412 29506340
Acidosis 25.58 20.46 41 31734 9664 29533088
Haematuria 25.21 20.46 8 31767 44131 29498621
Accident 25.02 20.46 25 31750 3663 29539089
Cellulitis 24.98 20.46 9 31766 45831 29496921
Fall 24.84 20.46 102 31673 177076 29365676
Musculoskeletal stiffness 24.84 20.46 5 31770 37453 29505299
Myocardial fibrosis 24.71 20.46 15 31760 1053 29541699
Hypersensitivity 24.69 20.46 13 31762 52890 29489862
Bradypnoea 23.77 20.46 20 31755 2351 29540401
Abdominal distension 23.39 20.46 10 31765 45901 29496851
Pupil fixed 22.79 20.46 17 31758 1679 29541073
Haemoptysis 22.66 20.46 3 31772 30547 29512205
Bronchitis 22.31 20.46 6 31769 36862 29505890
Opiates positive 22.30 20.46 11 31764 511 29542241
Dyspepsia 22.24 20.46 3 31772 30122 29512630
Legal problem 21.97 20.46 8 31767 172 29542580
Substance use disorder 21.95 20.46 9 31766 269 29542483
Behavioural addiction 21.80 20.46 5 31770 17 29542735
Sensorimotor disorder 21.69 20.46 10 31765 399 29542353
Alcoholic liver disease 21.57 20.46 11 31764 549 29542203
Accidental exposure to product 21.24 20.46 40 31735 10713 29532039
Electrocardiogram QRS complex prolonged 21.05 20.46 24 31751 4086 29538666
Dextrocardia 21.03 20.46 7 31768 114 29542638
Somnambulism 20.91 20.46 20 31755 2778 29539974
Drug hypersensitivity 20.64 20.46 135 31640 68271 29474481
Acute hepatic failure 20.63 20.46 42 31733 11910 29530842
C-reactive protein increased 20.47 20.46 11 31764 44252 29498500

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 14765.78 19.41 5956 51444 218458 64222874
Drug abuse 10312.98 19.41 3989 53411 128385 64312947
Toxicity to various agents 9753.67 19.41 5191 52209 358322 64083010
Cardio-respiratory arrest 3297.80 19.41 1648 55752 96745 64344587
Intentional overdose 2189.27 19.41 1218 56182 88726 64352606
Respiratory arrest 2121.75 19.41 1004 56396 51981 64389351
Intentional product misuse 1871.02 19.41 1020 56380 71275 64370057
Overdose 1797.47 19.41 1329 56071 158237 64283095
Poisoning 1730.97 19.41 672 56728 21207 64420125
Cardiac arrest 1491.44 19.41 1173 56227 152891 64288441
Death 1276.47 19.41 1835 55565 480870 63960462
Suicide attempt 896.28 19.41 635 56765 70372 64370960
Alcohol interaction 864.80 19.41 267 57133 4134 64437198
Alcohol use 786.63 19.41 251 57149 4351 64436981
Exposure via ingestion 783.24 19.41 254 57146 4648 64436684
Alcohol poisoning 735.23 19.41 234 57166 4021 64437311
Alcohol abuse 697.05 19.41 232 57168 4620 64436712
Suspected suicide 586.71 19.41 238 57162 8416 64432916
Coma 444.63 19.41 465 56935 87150 64354182
Poisoning deliberate 412.41 19.41 213 57187 13245 64428087
Substance abuse 410.97 19.41 189 57211 9103 64432229
Drug dependence 374.43 19.41 278 57122 33034 64408298
Diarrhoea 339.64 19.41 111 57289 722593 63718739
Drug ineffective 307.16 19.41 185 57215 840062 63601270
Blood alcohol increased 302.67 19.41 88 57312 1094 64440238
Drug hypersensitivity 300.62 19.41 657 56743 237158 64204174
Fatigue 267.65 19.41 169 57231 748561 63692771
Pneumonia 262.44 19.41 86 57314 559490 63881842
Dyspnoea 259.90 19.41 160 57240 718514 63722818
Off label use 236.95 19.41 135 57265 632671 63808661
Asphyxia 219.47 19.41 125 57275 9441 64431891
Anaemia 219.05 19.41 37 57363 378643 64062689
Exposure to toxic agent 213.56 19.41 106 57294 6053 64435279
Nausea 211.04 19.41 234 57166 785566 63655766
Accidental death 203.92 19.41 88 57312 3637 64437695
Pyrexia 200.80 19.41 125 57275 558519 63882813
Drug abuser 189.73 19.41 96 57304 5712 64435620
Headache 188.14 19.41 120 57280 529347 63911985
Pain 183.97 19.41 135 57265 553376 63887956
Aggression 173.70 19.41 210 57190 46022 64395310
Asthenia 169.20 19.41 85 57315 427959 64013373
Arthralgia 164.33 19.41 95 57305 442165 63999167
Respiratory depression 161.01 19.41 147 57253 23296 64418036
Cough 160.98 19.41 36 57364 302112 64139220
Intentional self-injury 159.51 19.41 161 57239 28883 64412449
Rash 149.46 19.41 114 57286 458435 63982897
Neutropenia 148.64 19.41 19 57381 239605 64201727
Methaemoglobinaemia 145.34 19.41 73 57327 4275 64437057
Pain in extremity 144.59 19.41 45 57355 303040 64138292
Mydriasis 144.00 19.41 115 57285 15197 64426135
Agitation 135.88 19.41 265 57135 88102 64353230
Somnolence 135.68 19.41 444 56956 203201 64238131
Accidental overdose 133.56 19.41 157 57243 33400 64407932
Incorrect route of product administration 127.65 19.41 129 57271 23169 64418163
Condition aggravated 127.26 19.41 88 57312 372338 64068994
Back pain 125.06 19.41 34 57366 250137 64191195
Malaise 120.97 19.41 105 57295 396142 64045190
Drug use disorder 120.09 19.41 72 57328 5982 64435350
Blood ethanol increased 117.00 19.41 37 57363 621 64440711
Urinary tract infection 116.65 19.41 31 57369 231565 64209767
Dizziness 114.06 19.41 129 57271 430034 64011298
Febrile neutropenia 113.68 19.41 16 57384 187641 64253691
Disease progression 112.00 19.41 3 57397 141677 64299655
Sepsis 111.98 19.41 33 57367 230308 64211024
Decreased appetite 110.80 19.41 56 57344 281233 64160099
Product dose omission issue 110.33 19.41 20 57380 194727 64246605
Alcoholism 110.20 19.41 56 57344 3361 64437971
Unresponsive to stimuli 108.26 19.41 175 57225 50218 64391114
Miosis 102.64 19.41 89 57311 13177 64428155
Depressed level of consciousness 99.19 19.41 222 57178 81214 64360118
Haemoglobin decreased 98.42 19.41 26 57374 195037 64246295
Metabolic acidosis 96.20 19.41 202 57198 70756 64370576
Joint swelling 95.69 19.41 36 57364 215346 64225986
Drug screen positive 95.52 19.41 61 57339 5668 64435664
White blood cell count decreased 94.32 19.41 14 57386 157823 64283509
Medication error 93.33 19.41 163 57237 49803 64391529
Pancytopenia 92.20 19.41 10 57390 143299 64298033
Pruritus 91.43 19.41 86 57314 312314 64129018
Constipation 91.28 19.41 45 57355 229292 64212040
Environmental exposure 88.77 19.41 26 57374 332 64441000
Alcohol withdrawal syndrome 87.05 19.41 39 57361 1764 64439568
Weight decreased 85.58 19.41 77 57323 285662 64155670
Oedema peripheral 82.59 19.41 42 57358 210275 64231057
Loss of consciousness 81.82 19.41 304 57096 148061 64293271
Cerebrovascular accident 80.39 19.41 13 57387 137570 64303762
Thrombocytopenia 80.26 19.41 50 57350 223751 64217581
Abdominal pain 79.15 19.41 97 57303 312278 64129054
Peripheral swelling 78.85 19.41 44 57356 209109 64232223
Malignant neoplasm progression 77.62 19.41 6 57394 112865 64328467
Cardiac failure congestive 77.06 19.41 12 57388 130568 64310764
Tachycardia 76.31 19.41 299 57101 149280 64292052
Platelet count decreased 76.22 19.41 27 57373 167684 64273648
Pulmonary oedema 74.89 19.41 195 57205 78479 64362853
Dehydration 74.23 19.41 51 57349 216712 64224620
Postmortem blood drug level abnormal 73.64 19.41 26 57374 621 64440711
Fall 73.47 19.41 164 57236 416662 64024670
Chest pain 72.56 19.41 62 57338 235918 64205414
Drug withdrawal syndrome 71.79 19.41 112 57288 31179 64410153
Electrocardiogram QRS complex prolonged 69.46 19.41 61 57339 9183 64432149
Bronchitis 68.90 19.41 8 57392 108735 64332597
Muscular weakness 68.08 19.41 15 57385 127323 64314009
Intentional product use issue 68.01 19.41 213 57187 95151 64346181
Shock 67.86 19.41 122 57278 38118 64403214
Interstitial lung disease 67.75 19.41 5 57395 97727 64343605
Infusion related reaction 67.37 19.41 31 57369 164436 64276896
Erythema 66.77 19.41 42 57358 187028 64254304
Nasopharyngitis 65.98 19.41 47 57353 196026 64245306
Pulmonary embolism 65.75 19.41 24 57376 146332 64295000
Weight increased 65.65 19.41 56 57344 213292 64228040
Acute kidney injury 63.02 19.41 198 57202 449042 63992290
Influenza 62.38 19.41 10 57390 106521 64334811
Homicide 62.37 19.41 27 57373 1124 64440208
Suicidal ideation 61.35 19.41 163 57237 66379 64374953
Herpes zoster 58.04 19.41 3 57397 79184 64362148
Mobility decreased 57.81 19.41 5 57395 85835 64355497
Drug intolerance 57.03 19.41 50 57350 187942 64253390
Withdrawal syndrome 56.57 19.41 86 57314 23406 64417926
Therapeutic product effect incomplete 55.69 19.41 12 57388 103470 64337862
Septic shock 55.19 19.41 13 57387 105424 64335908
Sinus tachycardia 54.96 19.41 101 57299 32087 64409245
Sopor 54.39 19.41 96 57304 29565 64411767
Leukopenia 53.96 19.41 12 57388 101230 64340102
Neuropathy peripheral 53.25 19.41 19 57381 117506 64323826
Pulmonary congestion 52.73 19.41 84 57316 23796 64417536
General physical health deterioration 51.19 19.41 64 57336 204361 64236971
Product use in unapproved indication 51.17 19.41 49 57351 176569 64264763
Cardiac failure 51.10 19.41 27 57373 132346 64308986
Neutrophil count decreased 50.63 19.41 5 57395 77191 64364141
Blood pressure increased 48.69 19.41 49 57351 172503 64268829
Pleural effusion 48.58 19.41 26 57374 126533 64314799
Cellulitis 48.14 19.41 12 57388 93645 64347687
Abdominal distension 48.00 19.41 13 57387 95981 64345351
Musculoskeletal stiffness 47.75 19.41 25 57375 123181 64318151
Asthma 47.42 19.41 13 57387 95212 64346120
Renal impairment 47.23 19.41 31 57369 134986 64306346
Myalgia 47.13 19.41 43 57357 158574 64282758
Electrocardiogram QT prolonged 46.46 19.41 166 57234 79282 64362050
Urticaria 46.12 19.41 38 57362 147279 64294053
Rheumatoid arthritis 45.96 19.41 47 57353 164247 64277085
Chest discomfort 45.83 19.41 23 57377 116083 64325249
Myocardial infarction 45.75 19.41 48 57352 165773 64275559
Injection site pain 45.61 19.41 21 57379 111387 64329945
C-reactive protein increased 45.35 19.41 14 57386 94895 64346437
Alcohol intolerance 45.32 19.41 16 57384 382 64440950
Dyspnoea exertional 45.29 19.41 6 57394 73724 64367608
Toxicologic test abnormal 45.20 19.41 22 57378 1203 64440129
Productive cough 44.87 19.41 6 57394 73197 64368135
Treatment failure 44.83 19.41 24 57376 116792 64324540
Oropharyngeal pain 44.50 19.41 12 57388 88855 64352477
Haematochezia 44.33 19.41 4 57396 66369 64374963
Loss of personal independence in daily activities 44.26 19.41 6 57394 72448 64368884
Hypertension 44.00 19.41 104 57296 259157 64182175
COVID-19 43.30 19.41 4 57396 65136 64376196
Acidosis 42.64 19.41 65 57335 17730 64423602
Atrial fibrillation 42.37 19.41 54 57346 171035 64270297
Road traffic accident 42.20 19.41 88 57312 30657 64410675
Abdominal pain upper 41.55 19.41 57 57343 174973 64266359
Therapeutic product effect decreased 41.00 19.41 26 57374 115325 64326007
Chronic obstructive pulmonary disease 40.85 19.41 7 57393 71041 64370291
Arthritis 40.70 19.41 12 57388 83802 64357530
Rash pruritic 39.60 19.41 3 57397 57401 64383931
Sinusitis 39.41 19.41 43 57357 145885 64295447
Osteoarthritis 39.28 19.41 5 57395 63331 64378001
Infection 39.25 19.41 65 57335 184815 64256517
Psoriasis 39.23 19.41 8 57392 71695 64369637
Opiates positive 38.86 19.41 18 57382 880 64440452
Blood ethanol 38.81 19.41 11 57389 124 64441208
Thrombosis 38.40 19.41 8 57392 70634 64370698
Wheezing 38.29 19.41 12 57388 80567 64360765
Aspiration 38.12 19.41 60 57340 16825 64424507
Dysphagia 38.07 19.41 24 57376 106788 64334544
Product administration error 37.79 19.41 79 57321 27564 64413768
Hyponatraemia 37.58 19.41 46 57354 148293 64293039
Brain oedema 37.35 19.41 69 57331 22006 64419326
Deep vein thrombosis 36.98 19.41 24 57376 105158 64336174
Drug reaction with eosinophilia and systemic symptoms 36.93 19.41 3 57397 54214 64387118
Inappropriate schedule of product administration 36.84 19.41 18 57382 92268 64349064
Gastrooesophageal reflux disease 36.72 19.41 14 57386 83129 64358203
Chills 36.45 19.41 41 57359 137223 64304109
Epistaxis 36.44 19.41 21 57379 98110 64343222
Nasal congestion 36.30 19.41 5 57395 59653 64381679
Drug interaction 36.18 19.41 486 56914 361597 64079735
Upper respiratory tract infection 36.12 19.41 10 57390 72775 64368557
Rectal haemorrhage 35.74 19.41 6 57394 61811 64379521
Substance use disorder 35.22 19.41 13 57387 354 64440978
Somnambulism 34.83 19.41 32 57368 5109 64436223
Victim of sexual abuse 33.91 19.41 13 57387 394 64440938
Drug level increased 33.80 19.41 86 57314 34110 64407222
Hypoaesthesia 33.31 19.41 45 57355 139063 64302269
Dyspepsia 33.08 19.41 15 57385 80297 64361035
Abnormal behaviour 32.66 19.41 84 57316 33538 64407794
Therapeutic response decreased 32.65 19.41 4 57396 52184 64389148
Haemoptysis 32.63 19.41 3 57397 49045 64392287
Stress 32.61 19.41 7 57393 60527 64380805
Gastrointestinal haemorrhage 32.50 19.41 42 57358 132270 64309062
Physical assault 32.26 19.41 19 57381 1527 64439805
Hyperkalaemia 31.75 19.41 26 57374 101103 64340229
Substance dependence 31.57 19.41 13 57387 477 64440855
Acute hepatic failure 31.56 19.41 71 57329 26041 64415291
Renal failure 31.51 19.41 72 57328 181616 64259716
Neck pain 31.39 19.41 8 57392 61525 64379807
Oedema 30.95 19.41 22 57378 91913 64349419
Hepatic fibrosis 30.88 19.41 31 57369 5521 64435811
Inflammation 30.54 19.41 10 57390 65290 64376042
Cluster headache 30.52 19.41 15 57385 838 64440494
Muscle spasms 30.47 19.41 49 57351 140974 64300358
Self-medication 30.44 19.41 27 57373 4118 64437214
Migraine 30.38 19.41 9 57391 62668 64378664
Abdominal discomfort 30.23 19.41 74 57326 182248 64259084
Alopecia 30.10 19.41 64 57336 165626 64275706
Hypersensitivity 30.07 19.41 83 57317 196369 64244963
Fluid retention 29.93 19.41 8 57392 59598 64381734
Pupil fixed 29.80 19.41 24 57376 3208 64438124
Syncope 29.38 19.41 60 57340 157575 64283757
Myocardial fibrosis 29.30 19.41 18 57382 1562 64439770
Liver injury 29.30 19.41 75 57325 29857 64411475
Gait disturbance 29.23 19.41 69 57331 172086 64269246
Amnesia 29.20 19.41 102 57298 48167 64393165
Chemical submission 29.18 19.41 10 57390 218 64441114
Bradypnoea 29.05 19.41 29 57371 5130 64436202
Pneumonitis 28.87 19.41 5 57395 50360 64390972
Exposure via inhalation 28.74 19.41 8 57392 84 64441248
Chronic kidney disease 28.66 19.41 8 57392 57911 64383421
Amphetamines positive 28.64 19.41 10 57390 231 64441101
Brain death 28.62 19.41 28 57372 4833 64436499
Bezoar 28.41 19.41 20 57380 2183 64439149
Hospitalisation 28.06 19.41 16 57384 75191 64366141
Influenza like illness 27.90 19.41 10 57390 61692 64379640
Suicidal behaviour 27.82 19.41 22 57378 2865 64438467
Postmortem blood drug level 27.67 19.41 10 57390 256 64441076
Cataract 27.46 19.41 6 57394 51256 64390076
Blood pH decreased 27.13 19.41 26 57374 4376 64436956
Coma scale abnormal 27.06 19.41 34 57366 7740 64433592
Mucosal inflammation 26.87 19.41 11 57389 62573 64378759
Feeling abnormal 26.51 19.41 49 57351 133553 64307779
Dysarthria 26.50 19.41 114 57286 59292 64382040
Euphoric mood 26.48 19.41 31 57369 6560 64434772
Haematocrit decreased 26.21 19.41 8 57392 54647 64386685
Transient ischaemic attack 26.19 19.41 4 57396 44178 64397154
Impaired driving ability 25.91 19.41 26 57374 4628 64436704
Housebound 25.50 19.41 11 57389 454 64440878
Diabetes mellitus 25 19.41 14 57386 66460 64374872
Brain injury 24.73 19.41 37 57363 9928 64431404
Gun shot wound 24.66 19.41 14 57386 1050 64440282
Skin exfoliation 24.57 19.41 5 57395 44880 64396452
Acute myocardial infarction 24.38 19.41 16 57384 69702 64371630
Compartment syndrome 24.22 19.41 24 57376 4208 64437124
Haemorrhage 24.17 19.41 21 57379 79330 64362002
Orthostatic hypotension 23.99 19.41 6 57394 46732 64394600
Lymphadenopathy 23.95 19.41 6 57394 46680 64394652
Injection site swelling 23.93 19.41 4 57396 41349 64399983
Drug diversion 23.81 19.41 14 57386 1122 64440210
Agranulocytosis 23.75 19.41 3 57397 38226 64403106
Cardiac disorder 23.66 19.41 10 57390 55806 64385526
Ascites 23.40 19.41 13 57387 61988 64379344
Analgesic drug level increased 23.39 19.41 18 57382 2252 64439080
Red blood cell count decreased 23.36 19.41 7 57393 48379 64392953
Hypothyroidism 23.22 19.41 4 57396 40453 64400879
Accidental poisoning 23.06 19.41 15 57385 1438 64439894
Victim of chemical submission 22.93 19.41 9 57391 291 64441041
Protein C increased 22.92 19.41 7 57393 104 64441228
Palpitations 22.85 19.41 36 57364 104452 64336880
Cystitis 22.85 19.41 5 57395 42670 64398662
Seizure 22.82 19.41 238 57162 166654 64274678
Vertigo 22.82 19.41 12 57388 58999 64382333
Bone pain 22.75 19.41 7 57393 47565 64393767
Sudden death 22.47 19.41 53 57347 20043 64421289
Hepatic failure 22.22 19.41 103 57297 55291 64386041
Clostridium difficile infection 22.07 19.41 3 57397 36160 64405172
Drug eruption 22.05 19.41 3 57397 36133 64405199
Rhinorrhoea 22.02 19.41 13 57387 59956 64381376
Paraesthesia 21.97 19.41 55 57345 134467 64306865
Hepatitis alcoholic 21.96 19.41 10 57390 470 64440862
Angioedema 21.87 19.41 14 57386 61807 64379525
Vision blurred 21.84 19.41 29 57371 90287 64351045
Accidental exposure to product 21.72 19.41 62 57338 26302 64415030
Psoriatic arthropathy 21.37 19.41 6 57394 43275 64398057
Lymphocyte count decreased 21.33 19.41 5 57395 40694 64400638
Pulmonary hypertension 21.26 19.41 6 57394 43133 64398199
Iodine allergy 21.05 19.41 10 57390 518 64440814
Alcoholic liver disease 21.05 19.41 10 57390 518 64440814
Haematuria 20.98 19.41 14 57386 60457 64380875
Respiratory acidosis 20.85 19.41 34 57366 9821 64431511
Type 2 diabetes mellitus 20.35 19.41 3 57397 34017 64407315
Cerebral haemorrhage 20.33 19.41 10 57390 51080 64390252
Dysphonia 20.16 19.41 8 57392 46374 64394958
Skin ulcer 20.10 19.41 7 57393 43967 64397365
Rhabdomyolysis 19.97 19.41 145 57255 91581 64349751
Nephrolithiasis 19.88 19.41 7 57393 43676 64397656
Hyperreflexia 19.86 19.41 28 57372 7120 64434212
Lung disorder 19.81 19.41 15 57385 60685 64380647
Alcoholic 19.64 19.41 5 57395 36 64441296
Visceral congestion 19.55 19.41 11 57389 811 64440521
Fibromyalgia 19.51 19.41 4 57396 35727 64405605
Pain in jaw 19.48 19.41 6 57394 40749 64400583
Multiple injuries 19.42 19.41 19 57381 3280 64438052

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hyperbilirubinaemia 17.31 12.71 3 3 63 84609

Pharmacologic Action:

SourceCodeDescription
ATC D08AX08 DERMATOLOGICALS
ANTISEPTICS AND DISINFECTANTS
ANTISEPTICS AND DISINFECTANTS
Other antiseptics and disinfectants
ATC V03AB16 VARIOUS
ALL OTHER THERAPEUTIC PRODUCTS
ALL OTHER THERAPEUTIC PRODUCTS
Antidotes
ATC V03AZ01 VARIOUS
ALL OTHER THERAPEUTIC PRODUCTS
ALL OTHER THERAPEUTIC PRODUCTS
Nerve depressants
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000891 Anti-Infective Agents, Local
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D012997 Solvents
CHEBI has role CHEBI:35488 central nervous system depressants
CHEBI has role CHEBI:48218 antiseptics
CHEBI has role CHEBI:48219 disinfectants
CHEBI has role CHEBI:48354 polar solvent
CHEBI has role CHEBI:50905 teratogeno
CHEBI has role CHEBI:50910 agente neurotoxico
CHEBI has role CHEBI:60643 N-methyl-D-aspartate receptor antagonists
CHEBI has role CHEBI:64018 protein kinase C agonists
CHEBI has role CHEBI:75771 Mus musculus metabolites
CHEBI has role CHEBI:75772 S. cerevisiae metabolites
CHEBI has role CHEBI:76971 Escherichia coli metabolites
CHEBI has role CHEBI:77746 Homo sapiens metabolite

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Antiseptic preparation indication 261276004




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
99% (1ML) ABLYSINOL BELCHER N207987 June 21, 2018 RX SOLUTION INTRA-ARTERIAL June 21, 2025 INDICATED TO INDUCE CONTROLLED CARDIAC SEPTAL INFRACTION TO IMPROVE EXERCISE CAPACITY IN ADULTS WITH SYMPTOMATIC HYPERTROPHIC OBSTRUCTIVE CARDIOMYOPATHY WHO ARE NOT CANDIDATES FOR SURGICAL MYECTOMY
99% (5ML) ABLYSINOL BELCHER N207987 June 21, 2018 RX SOLUTION INTRA-ARTERIAL June 21, 2025 INDICATED TO INDUCE CONTROLLED CARDIAC SEPTAL INFRACTION TO IMPROVE EXERCISE CAPACITY IN ADULTS WITH SYMPTOMATIC HYPERTROPHIC OBSTRUCTIVE CARDIOMYOPATHY WHO ARE NOT CANDIDATES FOR SURGICAL MYECTOMY

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Glutamate receptor ionotropic, NMDA 3A Ion channel WOMBAT-PK
Glycine receptor subunit alpha-1 Ion channel WOMBAT-PK
Glycine receptor subunit alpha-2 Ion channel WOMBAT-PK
GABA A receptor alpha-4/beta-2/delta Ion channel WOMBAT-PK

External reference:

IDSource
4017736 VUID
N0000146104 NUI
D06542 KEGG_DRUG
4017424 VANDF
4017736 VANDF
C0001962 UMLSCUI
CHEBI:16236 CHEBI
EOH PDB_CHEM_ID
CHEMBL545 ChEMBL_ID
702 PUBCHEM_CID
DB00898 DRUGBANK_ID
D000431 MESH_DESCRIPTOR_UI
2299 IUPHAR_LIGAND_ID
3K9958V90M UNII
448 RXNORM
10010 MMSL
4693 MMSL
9888 MMSL
d03162 MMSL
001539 NDDF
002464 NDDF
333164008 SNOMEDCT_US
398624005 SNOMEDCT_US
419442005 SNOMEDCT_US
53041004 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
TRISEPTINHAND AND BODY ANTISEPTIC HUMAN OTC DRUG LABEL 1 0064-1050 LOTION 0.70 mL TOPICAL OTC monograph not final 9 sections
SURGICEPT Waterless, Surgical Handscrub and Healthcare Personnel Handwash HUMAN OTC DRUG LABEL 1 0064-1080 SOLUTION 0.75 mL TOPICAL OTC monograph not final 10 sections
hand sanitizer HUMAN OTC DRUG LABEL 1 0113-7077 GEL 70 mL TOPICAL OTC monograph not final 12 sections
Humphreys Alcoholado Maravilla HUMAN OTC DRUG LABEL 1 0219-2020 LIQUID 70 mL TOPICAL OTC MONOGRAPH NOT FINAL 13 sections
Nozin Nasal Sanitizer HUMAN OTC DRUG LABEL 1 0295-9025 LIQUID 62 mL TOPICAL OTC monograph not final 9 sections
Keri Clinical Care Hand Sanitizing Gel - HEALTHCARE HUMAN OTC DRUG LABEL 1 0316-0214 GEL 0.70 mL TOPICAL OTC monograph not final 11 sections
Keri Clinical Care Hand Sanitizing Gel HUMAN OTC DRUG LABEL 1 0316-0292 GEL 0.70 mL TOPICAL OTC monograph not final 11 sections
SeptoSan Hand Sanitizer HUMAN OTC DRUG LABEL 1 0362-6000 LIQUID 60 L TOPICAL OTC MONOGRAPH NOT FINAL 14 sections
SeptoSan Hand Sanitizer HUMAN OTC DRUG LABEL 1 0362-6001 LIQUID 60 L TOPICAL OTC MONOGRAPH NOT FINAL 14 sections
SeptoSan Hand Sanitizer HUMAN OTC DRUG LABEL 1 0362-6002 LIQUID 60 L TOPICAL OTC MONOGRAPH NOT FINAL 14 sections
Alcohol HUMAN OTC DRUG LABEL 1 0363-0046 LIQUID 62 mg TOPICAL OTC monograph not final 12 sections
Iodine HUMAN OTC DRUG LABEL 3 0363-0088 LIQUID 470 mg TOPICAL OTC monograph not final 12 sections
Advanced Hand Sanitizer HUMAN OTC DRUG LABEL 1 0363-0370 GEL 70 mL TOPICAL OTC monograph not final 12 sections
Hand Sanitizer HUMAN OTC DRUG LABEL 1 0363-0469 GEL 545 mg TOPICAL OTC monograph not final 12 sections
Hand Sanitizer HUMAN OTC DRUG LABEL 1 0363-0469 GEL 545 mg TOPICAL OTC monograph not final 12 sections
Hand Sanitizer HUMAN OTC DRUG LABEL 1 0363-0596 GEL 567 mg TOPICAL OTC monograph not final 12 sections
Hand Sanitizer HUMAN OTC DRUG LABEL 1 0363-0643 GEL 558 mg TOPICAL OTC monograph not final 11 sections
Crisp Apple Hand Sani HUMAN OTC DRUG LABEL 1 0363-0663 LIQUID 585 g TOPICAL OTC monograph not final 13 sections
Ethyl Rubbing Alcohol HUMAN OTC DRUG LABEL 1 0363-0876 LIQUID 610 mg TOPICAL OTC monograph not final 13 sections
Ethyl Rubbing Alcohol HUMAN OTC DRUG LABEL 1 0363-0876 LIQUID 610 mg TOPICAL OTC monograph not final 13 sections
Hand Sanitizer HUMAN OTC DRUG LABEL 1 0363-0890 GEL 567 mg TOPICAL OTC monograph not final 11 sections
Hand Sanitizer HUMAN OTC DRUG LABEL 1 0363-0898 GEL 567 mg TOPICAL OTC monograph not final 11 sections
Advanced Hand Sanitizer HUMAN OTC DRUG LABEL 1 0363-0952 GEL 700 mg TOPICAL OTC monograph not final 12 sections
WALGREENS ADVANCED HAND SANITIZER WITH FRESH SCENT HUMAN OTC DRUG LABEL 1 0363-0967 AEROSOL, SPRAY 70 mg TOPICAL OTC monograph not final 12 sections
Hand Sanitizer HUMAN OTC DRUG LABEL 1 0363-0968 LOTION 558 mg TOPICAL OTC monograph not final 13 sections
Walgreens Advanced Hand Sanitizer Citrus Scent HUMAN OTC DRUG LABEL 1 0363-0969 AEROSOL, SPRAY 70 mg TOPICAL OTC monograph not final 12 sections
Hand Sanitizer HUMAN OTC DRUG LABEL 1 0363-0984 GEL 567 mg TOPICAL OTC monograph not final 11 sections
A Little Something Eucalyptus Mist Hand Sanitier HUMAN OTC DRUG LABEL 1 0363-1050 LIQUID 700 mg TOPICAL OTC monograph not final 1 sections
A Little Something Eucalyptus Mist Hand Sanitier HUMAN OTC DRUG LABEL 1 0363-1050 LIQUID 700 mg TOPICAL OTC monograph not final 1 sections
A Little Something Prosecco Bubbles Hand Sanitizer HUMAN OTC DRUG LABEL 1 0363-1051 LIQUID 700 mg TOPICAL OTC monograph not final 1 sections