ethanol Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
1076 64-17-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • alcohol
  • ethanol
  • ethyl alcohol
  • grain alcohol
A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in ALCOHOLIC BEVERAGES.
  • Molecular weight: 46.07
  • Formula: C2H6O
  • CLOGP: -0.24
  • LIPINSKI: 0
  • HAC: 1
  • HDO: 1
  • TPSA: 20.23
  • ALOGS: 1.10
  • ROTB: 0

Drug dosage:

None

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 2.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 2170.63 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 80 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
Jan. 17, 1946 FDA B BRAUN

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 11531.60 95.67 2338 3929 18696 2333122
Toxicity to various agents 7036.85 95.67 1710 4557 31044 2320774
Drug abuse 2970.07 95.67 715 5552 11311 2340507
Cardio-respiratory arrest 2614.13 95.67 613 5654 8533 2343285
Intentional overdose 1794.26 95.67 474 5793 10847 2340971
Respiratory arrest 1539.27 95.67 372 5895 5806 2346012
Cardiac arrest 1435.88 95.67 423 5844 14507 2337311
Drug hypersensitivity 1431.83 95.67 559 5708 46084 2305734
Death 1325.69 95.67 622 5645 80846 2270972
Overdose 1254.24 95.67 408 5859 19499 2332319
Poisoning 1189.28 95.67 261 6006 2559 2349259
Suicide attempt 1136.97 95.67 332 5935 10950 2340868
Intentional product misuse 1124.98 95.67 317 5950 9172 2342646
Exposure via ingestion 491.69 95.67 101 6166 687 2351131
Alcohol poisoning 475.90 95.67 86 6181 258 2351560
Somnolence 463.10 95.67 207 6060 23278 2328540
Alcohol use 367.37 95.67 73 6194 409 2351409
Coma 366.27 95.67 134 6133 8922 2342896
Alcohol abuse 216.81 95.67 44 6223 278 2351540
Poisoning deliberate 211.68 95.67 55 6212 1136 2350682
Hypotension 198.83 95.67 132 6135 32304 2319514
Intentional self-injury 155.28 95.67 58 6209 4069 2347749
Tachycardia 144.00 95.67 84 6183 16325 2335493
Agitation 139.64 95.67 72 6195 10979 2340839
Vomiting 133.73 95.67 147 6120 71455 2280363
Mydriasis 132.57 95.67 44 6223 2175 2349643
Seizure 131.73 95.67 92 6175 24374 2327444
Alcohol interaction 129.12 95.67 28 6239 253 2351565
Loss of consciousness 128.57 95.67 82 6185 18685 2333133
Alcoholism 122.29 95.67 28 6239 331 2351487
Unresponsive to stimuli 105.36 95.67 46 6221 4830 2346988
Blood alcohol increased 104.95 95.67 21 6246 122 2351696
Depressed level of consciousness 103.16 95.67 52 6215 7552 2344266
Accidental death 98.64 95.67 23 6244 296 2351522

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 7652.45 78.02 1779 4780 14533 1725689
Drug abuse 7336.58 78.02 1667 4892 12022 1728200
Toxicity to various agents 6866.21 78.02 1828 4731 27313 1712909
Cardio-respiratory arrest 2397.76 78.02 640 5919 8653 1731569
Intentional product misuse 1547.67 78.02 433 6126 6925 1733297
Intentional overdose 1416.75 78.02 408 6151 7262 1732960
Poisoning 1399.86 78.02 323 6236 2209 1738013
Respiratory arrest 1301.31 78.02 360 6199 5479 1734743
Death 1229.93 78.02 725 5834 86718 1653504
Cardiac arrest 1112.20 78.02 405 6154 15525 1724697
Overdose 1056.58 78.02 395 6164 16306 1723916
Suicide attempt 794.22 78.02 260 6299 7121 1733101
Alcohol abuse 779.51 78.02 155 6404 442 1739780
Exposure via ingestion 613.85 78.02 130 6429 550 1739672
Alcohol poisoning 532.05 78.02 110 6449 402 1739820
Substance abuse 402.09 78.02 99 6460 904 1739318
Drug dependence 280.98 78.02 98 6461 3229 1736993
Coma 270.33 78.02 118 6441 7144 1733078
Alcohol use 237.72 78.02 63 6496 788 1739434
Poisoning deliberate 233.61 78.02 62 6497 780 1739442
Blood alcohol increased 192.85 78.02 39 6520 123 1740099
Alcohol interaction 185.44 78.02 43 6516 294 1739928
Respiratory depression 185.05 78.02 65 6494 2182 1738040
Asphyxia 182.60 78.02 54 6505 1029 1739193
Accidental death 181.13 78.02 44 6515 376 1739846
Drug hypersensitivity 178.55 78.02 114 6445 15021 1725201
Aggression 176.12 78.02 91 6468 8024 1732198
Intentional product use issue 165.71 78.02 63 6496 2656 1737566
Incorrect route of product administration 164.49 78.02 67 6492 3398 1736824
Intentional self-injury 148.84 78.02 58 6501 2615 1737607
Hypotension 143.06 78.02 131 6428 29523 1710699
Unresponsive to stimuli 139.57 78.02 65 6494 4564 1735658
Somnolence 137.78 78.02 101 6458 16638 1723584
Metabolic acidosis 135.96 78.02 67 6492 5335 1734887
Tachycardia 126.63 78.02 86 6473 12542 1727680
Drug withdrawal syndrome 122.49 78.02 59 6500 4466 1735756
Suicidal ideation 117.63 78.02 71 6488 8447 1731775
Alcohol withdrawal syndrome 105.79 78.02 26 6533 234 1739988
Pulmonary oedema 104.31 78.02 60 6499 6526 1733696
Accidental overdose 102.82 78.02 51 6508 4113 1736109
Depressed level of consciousness 101.60 78.02 59 6500 6533 1733689
Loss of consciousness 100.84 78.02 80 6479 14795 1725427
Agitation 96.25 78.02 69 6490 10957 1729265
Road traffic accident 88.45 78.02 44 6515 3569 1736653
Sopor 82.46 78.02 35 6524 1966 1738256
Environmental exposure 80.99 78.02 16 6543 43 1740179

Pharmacologic Action:

SourceCodeDescription
ATC D08AX08 DERMATOLOGICALS
ANTISEPTICS AND DISINFECTANTS
ANTISEPTICS AND DISINFECTANTS
Other antiseptics and disinfectants
ATC V03AB16 VARIOUS
ALL OTHER THERAPEUTIC PRODUCTS
ALL OTHER THERAPEUTIC PRODUCTS
Antidotes
ATC V03AZ01 VARIOUS
ALL OTHER THERAPEUTIC PRODUCTS
ALL OTHER THERAPEUTIC PRODUCTS
Nerve depressants
CHEBI has role CHEBI:48218 antiseptic drug
CHEBI has role CHEBI:48354 polar solvent
CHEBI has role CHEBI:35488 central nervous system depressant
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000891 Anti-Infective Agents, Local
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D012997 Solvents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Antiseptic preparation indication 261276004

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
99% (1ML) ABLYSINOL BELCHER N207987 June 21, 2018 RX SOLUTION INTRA-ARTERIAL June 21, 2025 INDICATED TO INDUCE CONTROLLED CARDIAC SEPTAL INFRACTION TO IMPROVE EXERCISE CAPACITY IN ADULTS WITH SYMPTOMATIC HYPERTROPHIC OBSTRUCTIVE CARDIOMYOPATHY WHO ARE NOT CANDIDATES FOR SURGICAL MYECTOMY
99% (5ML) ABLYSINOL BELCHER N207987 June 21, 2018 RX SOLUTION INTRA-ARTERIAL June 21, 2025 INDICATED TO INDUCE CONTROLLED CARDIAC SEPTAL INFRACTION TO IMPROVE EXERCISE CAPACITY IN ADULTS WITH SYMPTOMATIC HYPERTROPHIC OBSTRUCTIVE CARDIOMYOPATHY WHO ARE NOT CANDIDATES FOR SURGICAL MYECTOMY

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
GABA A receptor alpha-4/beta-2/delta Ion channel WOMBAT-PK
Glycine receptor subunit alpha-2 Ion channel WOMBAT-PK
Glycine receptor subunit alpha-1 Ion channel WOMBAT-PK
Glutamate receptor ionotropic, NMDA 3A Ion channel WOMBAT-PK

External reference:

IDSource
D000431 MESH_DESCRIPTOR_UI
4017736 VUID
N0000146104 NUI
C0001962 UMLSCUI
D06542 KEGG_DRUG
3K9958V90M UNII
419442005 SNOMEDCT_US
398624005 SNOMEDCT_US
448 RXNORM
4693 MMSL
d03162 MMSL
10010 MMSL
9888 MMSL
4017424 VANDF
4017736 VANDF
002464 NDDF
001539 NDDF
702 PUBCHEM_CID
CHEBI:16236 CHEBI
CHEMBL545 ChEMBL_ID
DB00898 DRUGBANK_ID
EOH PDB_CHEM_ID
2299 IUPHAR_LIGAND_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
TRISEPTIN HUMAN OTC DRUG LABEL 1 0064-1050 LOTION 0.70 mL TOPICAL OTC monograph not final 9 sections
SURGICEPT HUMAN OTC DRUG LABEL 1 0064-1080 SOLUTION 0.75 mL TOPICAL OTC monograph not final 10 sections
Alcohol Antiseptic 80% HUMAN OTC DRUG LABEL 1 0065-8000 SOLUTION 80 mL TOPICAL OTC monograph not final 11 sections
Lupaneta Pack HUMAN PRESCRIPTION DRUG LABEL 3 0074-1052 KIT 0.70 mL None NDA 17 sections
Alcohol - Hand Sanitizer HUMAN OTC DRUG LABEL 1 0074-9857 SOLUTION 80 mL TOPICAL OTC monograph not final 13 sections
hand sanitizer HUMAN OTC DRUG LABEL 1 0113-7077 GEL 70 mL TOPICAL OTC monograph not final 9 sections
Humphreys Alcoholado Maravilla HUMAN OTC DRUG LABEL 1 0219-2020 LIQUID 70 mL TOPICAL OTC monograph not final 13 sections
Nozin Nasal Sanitizer HUMAN OTC DRUG LABEL 1 0295-9025 LIQUID 62 mL TOPICAL OTC monograph not final 9 sections
SeptoSan HUMAN OTC DRUG LABEL 1 0362-6000 LIQUID 60 L TOPICAL OTC MONOGRAPH NOT FINAL 10 sections
SeptoSan HUMAN OTC DRUG LABEL 1 0362-6001 LIQUID 60 L TOPICAL OTC MONOGRAPH NOT FINAL 10 sections
SeptoSan HUMAN OTC DRUG LABEL 1 0362-6002 LIQUID 60 L TOPICAL OTC MONOGRAPH NOT FINAL 10 sections
Hand Sanitizer HUMAN OTC DRUG LABEL 1 0363-0469 GEL 545 mg TOPICAL OTC monograph not final 12 sections
Hand Sanitizer HUMAN OTC DRUG LABEL 1 0363-0643 GEL 558 mg TOPICAL OTC monograph not final 12 sections
Ethyl Rubbing Alcohol HUMAN OTC DRUG LABEL 1 0363-0876 LIQUID 610 mg TOPICAL OTC monograph not final 13 sections
Hand Sanitizer HUMAN OTC DRUG LABEL 1 0363-0890 GEL 567 mg TOPICAL OTC monograph not final 11 sections
Hand Sanitizer HUMAN OTC DRUG LABEL 1 0363-0898 GEL 567 mg TOPICAL OTC monograph not final 11 sections
Advanced Hand Sanitizer HUMAN OTC DRUG LABEL 1 0363-0952 GEL 700 mg TOPICAL OTC monograph not final 12 sections
Hand Sanitizer HUMAN OTC DRUG LABEL 1 0363-0968 LOTION 558 mg TOPICAL OTC monograph not final 13 sections
Hand Sanitizer HUMAN OTC DRUG LABEL 1 0363-0984 GEL 567 mg TOPICAL OTC monograph not final 12 sections
A Little Something Eucalyptus Mist Hand Sanitier HUMAN OTC DRUG LABEL 1 0363-1050 LIQUID 700 mg TOPICAL OTC monograph not final 9 sections
A Little Something Prosecco Bubbles Hand Sanitizer HUMAN OTC DRUG LABEL 1 0363-1051 LIQUID 700 mg TOPICAL OTC monograph not final
Well at Walgreens HUMAN OTC DRUG LABEL 1 0363-9300 LIQUID 70 mL TOPICAL OTC monograph not final 11 sections
WALGREENS INSTANT HAND SANITIZER HUMAN OTC DRUG LABEL 1 0363-9320 SPRAY 62 mL TOPICAL OTC monograph not final 10 sections
Ethyl Rubbing Alcohol HUMAN OTC DRUG LABEL 1 0395-0040 LIQUID 700 mg TOPICAL OTC monograph not final 13 sections
Humco Iodides Tincture HUMAN OTC DRUG LABEL 1 0395-1207 LIQUID 0.45 mL TOPICAL OTC monograph not final 13 sections
Iodine Tincture Mild HUMAN OTC DRUG LABEL 2 0395-1213 LIQUID 470 mg TOPICAL OTC monograph not final 9 sections
Humco Strong Iodine Tincture HUMAN OTC DRUG LABEL 3 0395-1219 LIQUID 850 mg TOPICAL OTC monograph not final 12 sections
Strong Iodine Tincture HUMAN OTC DRUG LABEL 1 0395-1220 LIQUID 850 mg TOPICAL OTC monograph not final 12 sections
Ethyl Rubbing Alcohol 70 Percent HUMAN OTC DRUG LABEL 1 0395-9100 LIQUID 700 mg TOPICAL OTC monograph not final 13 sections
Iodine Tincture Mild HUMAN OTC DRUG LABEL 2 0395-9118 LIQUID 470 mg TOPICAL OTC monograph not final 9 sections