duloxetine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
serotonin and/or norepinephrine reuptake inhibitors, fluoxetine derivatives 972 116539-59-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • yentreve
  • cymbalta
  • duloxetine
  • (S)-Duloxetine
  • duloxetine hydrochloride
  • duloxetine HCl
A thiophene derivative and selective NEUROTRANSMITTER UPTAKE INHIBITOR for SEROTONIN and NORADRENALINE (SNRI). It is an ANTIDEPRESSIVE AGENT and ANXIOLYTIC, and is also used for the treatment of pain in patients with DIABETES MELLITUS and FIBROMYALGIA.
  • Molecular weight: 297.42
  • Formula: C18H19NOS
  • CLOGP: 4.26
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 1
  • TPSA: 21.26
  • ALOGS: -5
  • ROTB: 6
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
60 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 2.88 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 50 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
CL (Clearance) 8.57 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.04 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 12 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 1.976 Moderate 0.70
caco2-efflux Caco-2 efflux ratio (BA/AB) 0.813 Moderate 0.70
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 36.728 10^-6 cm/s Moderate 0.70
dh-clint Dog hepatocyte intrinsic clearance 26.792 uL/min/10^6 cells Moderate 0.70
dppb Dog plasma protein binding (% unbound) 2.800 % Moderate 0.70
fcs-ppb Fetal calf serum protein binding (% unbound) 12.430 % Moderate 0.70
herg hERG pIC50 5.731 pIC50 Moderate 0.70
hh-clint Human hepatocyte intrinsic clearance 8.995 uL/min/10^6 cells Moderate 0.70
hlm-clint Human liver microsomal intrinsic clearance 12.162 uL/min/mg protein Moderate 0.70
hppb Human plasma protein binding (% unbound) 6.140 % Moderate 0.70
kinase-safety-class ACVR2A,ACVR2B,AKT1,AKT2,AKT3,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,CHEK1,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,ITK,JAK2,JAK3,MAP3K21,MAP3K7,MAPK10,MAPK12,MAPK7,MAPKAPK2,MET,NTRK2,PAK4,PDK2,PDK4,PDPK1,PIM2,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK 46
kinase-selectivity-class AKT3,AXL,BRAF,EIF2AK3,ERBB2,PDK4,PIK3CB,PIK3CD,STK33 9
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 2.301 Moderate 0.70
mh-clint Mouse hepatocyte intrinsic clearance 106.660 Moderate 0.70
mppb Mouse plasma protein binding (% unbound) 4.290 Moderate 0.70
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 8.395 Moderate 0.70
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pld-class Phospholipidosis risk class (1 = positive, 0 = negative) 1 High 1
pppb Pig plasma protein binding (% unbound) 11.160 % Moderate 0.70
rh-clint Rat hepatocyte intrinsic clearance 141.579 uL/min/10^6 cells Moderate 0.70
rh-fuinc Rat hepatocyte fraction unbound in incubation 22.750 % Moderate 0.70
rppb Rat plasma protein binding (% unbound) 5.960 % Moderate 0.70
solubility-dd Solubility at pH 7.4 in DMSO 722.770 uM Moderate 0.70

Approvals:

DateAgencyCompanyOrphan
Aug. 3, 2004 FDA LILLY

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug withdrawal syndrome 4435.39 9.64 2038 279290 26685 90320434
Dysphoria 3505.92 9.64 1131 280197 5023 90342096
Affect lability 2735.68 9.64 1265 280063 16798 90330321
Irritability 2406.89 9.64 1455 279873 34207 90312912
Suicidal ideation 2305.74 9.64 1878 279450 71977 90275142
Agitation 1958.22 9.64 1641 279687 65457 90281662
Hyperhidrosis 1423.14 9.64 1928 279400 134377 90212742
Sensory disturbance 1390.42 9.64 760 280568 14653 90332466
Vertigo 1375.39 9.64 1370 279958 68441 90278678
Anxiety 1052.44 9.64 2698 278630 307074 90040045
Pemphigus 990.32 9.64 4 281324 326860 90020259
Nightmare 908.98 9.64 658 280670 21067 90326052
Paraesthesia 875.44 9.64 2205 279123 248121 90098998
Serotonin syndrome 873.43 9.64 811 280517 37076 90310043
Insomnia 837.72 9.64 2604 278724 330870 90016249
Glossodynia 809.82 9.64 47 281281 321732 90025387
Mood swings 802.91 9.64 599 280729 20103 90327016
Tremor 799.84 9.64 1584 279744 151589 90195530
Hand deformity 755.93 9.64 40 281288 296322 90050797
Dizziness 690.03 9.64 3626 277702 585658 89761461
Pericarditis 674.99 9.64 41 281287 270110 90077009
Completed suicide 666.33 9.64 1423 279905 143635 90203484
Duodenal ulcer perforation 663.17 9.64 4 281324 221284 90125835
Systemic lupus erythematosus 635.90 9.64 169 281159 361727 89985392
Tinnitus 621.07 9.64 717 280611 42385 90304734
Lethargy 618.98 9.64 867 280461 62272 90284847
Wound 604.35 9.64 106 281222 302874 90044245
Synovitis 588.83 9.64 149 281179 329603 90017516
Folliculitis 545.89 9.64 20 281308 204333 90142786
Anti-cyclic citrullinated peptide antibody positive 545.11 9.64 52 281276 236381 90110738
Helicobacter infection 507.16 9.64 56 281272 226794 90120325
Alopecia 487.51 9.64 491 280837 494580 89852539
Infusion related reaction 472.25 9.64 362 280966 416418 89930701
Muscle injury 469.37 9.64 18 281310 176636 90170483
Hypomania 460.13 9.64 307 281021 8590 90338529
Withdrawal syndrome 459.90 9.64 451 280877 22073 90325046
Contraindicated product administered 458.44 9.64 210 281118 319929 90027190
Headache 439.72 9.64 4343 276985 858403 89488716
Arthropathy 431.82 9.64 305 281023 365937 89981182
Suicide attempt 427.76 9.64 808 280520 74591 90272528
Nausea 402.08 9.64 5227 276101 1105089 89242030
Impaired healing 396.93 9.64 117 281211 234082 90113037
Maternal exposure during pregnancy 389.91 9.64 327 281001 359736 89987383
Abdominal discomfort 380.30 9.64 558 280770 476770 89870349
C-reactive protein abnormal 368.98 9.64 5 281323 127424 90219695
Rheumatoid factor positive 367.32 9.64 49 281279 171601 90175518
Sleep disorder due to general medical condition, insomnia type 364.46 9.64 7 281321 128687 90218432
Feeling abnormal 362.36 9.64 1243 280085 165992 90181127
Swelling 355.64 9.64 468 280860 418590 89928529
Lower respiratory tract infection 353.23 9.64 168 281160 250491 90096628
Blister 351.62 9.64 176 281152 254822 90092297
Joint swelling 349.11 9.64 644 280684 502656 89844463
Somnolence 345.00 9.64 1424 279904 207660 90139459
Discomfort 338.62 9.64 217 281111 274118 90073001
General physical health deterioration 330.47 9.64 369 280959 354746 89992373
Swollen joint count increased 328.18 9.64 3 281325 111203 90235916
Treatment failure 316.87 9.64 286 281042 303642 90043477
Irritable bowel syndrome 308.02 9.64 129 281199 207319 90139800
Stomatitis 305.32 9.64 243 281085 274455 90072664
Stubbornness 289.89 9.64 89 281239 323 90346796
Liver injury 278.56 9.64 91 281237 170476 90176643
Lip dry 276.21 9.64 8 281320 100947 90246172
Ill-defined disorder 276.05 9.64 114 281214 184777 90162342
Confusional state 274.69 9.64 2095 279233 384110 89963009
Disturbance in attention 272.31 9.64 509 280819 46600 90300519
Type 2 diabetes mellitus 262.98 9.64 152 281176 203092 90144027
Fall 250.99 9.64 2439 278889 479371 89867748
Facet joint syndrome 248.41 9.64 14 281314 98375 90248744
Coordination abnormal 247.02 9.64 318 281010 21038 90326081
Crying 245.07 9.64 348 280980 25297 90321822
Febrile neutropenia 242.33 9.64 94 281234 158255 90188864
Drug interaction 241.67 9.64 1577 279751 274876 90072243
Pulmonary fibrosis 226.85 9.64 32 281296 107471 90239648
Therapeutic product effect decreased 225.19 9.64 320 281008 277251 90069868
Depression 224.53 9.64 1650 279678 298951 90048168
Rash 224.05 9.64 1500 279828 794600 89552519
Mood altered 223.41 9.64 271 281057 16873 90330246
Mobility decreased 218.72 9.64 274 281054 250460 90096659
Blood cholesterol increased 211.66 9.64 200 281128 207812 90139307
Drug intolerance 209.68 9.64 701 280627 446890 89900229
Pyrexia 203.44 9.64 1210 280118 659275 89687844
Thinking abnormal 203.22 9.64 215 281113 11517 90335602
Hypersensitivity 198.97 9.64 733 280595 453944 89893175
Injury 198.16 9.64 192 281136 197157 90149962
Peripheral venous disease 197.21 9.64 17 281311 83904 90263215
Infection 194.69 9.64 532 280796 361562 89985557
Fatigue 193.98 9.64 4815 276513 1149208 89197911
Wound infection 193.75 9.64 46 281282 106356 90240763
Depressed mood 192.71 9.64 459 280869 49763 90297356
Live birth 185.96 9.64 16 281312 79091 90268028
Joint range of motion decreased 176.05 9.64 101 281227 135542 90211577
Hypercholesterolaemia 173.42 9.64 49 281279 100843 90246276
Personality disorder 172.50 9.64 203 281125 12241 90334878
Electric shock 172.31 9.64 91 281237 1631 90345488
Panic attack 169.03 9.64 298 281030 26067 90321052
Neutropenia 168.19 9.64 274 281054 224630 90122489
Abnormal behaviour 165.21 9.64 271 281057 22357 90324762
Thrombocytopenia 161.08 9.64 249 281079 208476 90138643
Tardive dyskinesia 161.05 9.64 184 281144 10746 90336373
Influenza like illness 160.53 9.64 583 280745 80028 90267091
Peripheral swelling 158.59 9.64 701 280627 412405 89934714
Anger 151.98 9.64 200 281128 13520 90333599
Product use issue 150.79 9.64 522 280806 329397 90017722
Multiple sclerosis 143.97 9.64 287 281041 27553 90319566
Coma 141.84 9.64 522 280806 72110 90275009
Toxicity to various agents 141.26 9.64 1440 279888 286406 90060713
Adjustment disorder with depressed mood 140.45 9.64 9 281319 56744 90290375
Blood pressure increased 138.90 9.64 1068 280260 196149 90150970
Wheezing 136.13 9.64 339 280989 237741 90109378
Inflammation 135.94 9.64 215 281113 178377 90168742
Affective disorder 135.31 9.64 143 281185 7650 90339469
Loss of consciousness 134.82 9.64 820 280508 139418 90207701
Myelosuppression 134.12 9.64 8 281320 53583 90293536
Product dose omission issue 134.07 9.64 1440 279888 290247 90056872
Inappropriate antidiuretic hormone secretion 133.58 9.64 227 281101 19278 90327841
Oedema 133.56 9.64 262 281066 200033 90147086
Lung disorder 132.52 9.64 162 281166 149721 90197398
Post-traumatic stress disorder 132.48 9.64 133 281195 6695 90340424
Anaemia 131.57 9.64 605 280723 352197 89994922
Grip strength decreased 130.38 9.64 62 281266 92514 90254605
Multiple sclerosis relapse 125.83 9.64 403 280925 51902 90295217
Pancytopenia 125.40 9.64 113 281215 120150 90226969
Autoimmune disorder 125.15 9.64 41 281287 76703 90270416
Hepatic enzyme increased 122.17 9.64 640 280688 360096 89987023
Blepharospasm 120.55 9.64 15 281313 55430 90291689
Neurologic neglect syndrome 120.44 9.64 143 281185 8704 90338415
Hallucination 119.65 9.64 463 280865 65496 90281623
Bursitis 118.83 9.64 140 281188 131514 90215605
Pneumonia aspiration 118.81 9.64 337 280991 40603 90306516
Carotid artery thrombosis 117.29 9.64 143 281185 8949 90338170
Skin haemorrhage 116.11 9.64 225 281103 21155 90325964
Adjustment disorder 113.74 9.64 145 281183 9497 90337622
Mental disorder 112.95 9.64 285 281043 32033 90315086
Seizure 111.62 9.64 834 280494 151795 90195324
Intentional product use issue 111.06 9.64 326 281002 216566 90130553
Vision blurred 109.24 9.64 650 280678 109643 90237476
Off label use 109.14 9.64 2599 278729 1099653 89247466
Onychomadesis 108.94 9.64 9 281319 45989 90301130
Nail disorder 106.61 9.64 26 281302 59041 90288078
Somatic symptom disorder 106.17 9.64 87 281241 3354 90343765
Restless legs syndrome 105.97 9.64 223 281105 22247 90324872
Product substitution issue 105.83 9.64 196 281132 17812 90329307
Intentional self-injury 104.95 9.64 261 281067 29073 90318046
Bone erosion 104.60 9.64 19 281309 53002 90294117
Lupus-like syndrome 104.31 9.64 14 281314 48832 90298287
Intentional overdose 104.09 9.64 570 280758 93264 90253855
Sopor 103.05 9.64 233 281095 24411 90322708
C-reactive protein increased 102.32 9.64 260 281068 181129 90165990
Dysphagia 101.32 9.64 646 280682 111632 90235487
Disease progression 99.18 9.64 211 281117 156404 90190715
Psoriatic arthropathy 99.13 9.64 369 280959 227966 90119153
Sciatica 99.00 9.64 101 281227 101281 90245838
Obesity 98.68 9.64 109 281219 105398 90241721
Alanine aminotransferase increased 97.17 9.64 665 280663 117673 90229446
Balance disorder 96.05 9.64 572 280756 96508 90250611
Gait inability 95.53 9.64 194 281134 146262 90200857
Hip arthroplasty 94.31 9.64 60 281268 76148 90270971
Aggression 94.06 9.64 236 281092 26432 90320687
Abnormal dreams 93.47 9.64 143 281185 11114 90336005
Hot flush 93.15 9.64 399 280929 59089 90288030
Reversible cerebral vasoconstriction syndrome 90.52 9.64 86 281242 4044 90343075
Nasal turbinate hypertrophy 90.26 9.64 48 281280 873 90346246
Dyskinesia 90.17 9.64 284 281044 36250 90310869
Sleep apnoea syndrome 89.86 9.64 259 281069 31488 90315631
Gastrointestinal disorder 89.34 9.64 451 280877 256236 90090883
Breast cancer stage II 89.26 9.64 5 281323 35329 90311790
Gastrointestinal tube insertion 88.60 9.64 54 281274 1286 90345833
Liver disorder 88.51 9.64 150 281178 121119 90226000
Gastric bypass 85.41 9.64 62 281266 1992 90345127
Sinus disorder 85.22 9.64 268 281060 34179 90312940
Malignant neoplasm progression 84.81 9.64 125 281203 106745 90240374
Mania 84.60 9.64 155 281173 13969 90333150
Hallucination, visual 84.23 9.64 207 281121 22885 90324234
Drug abuse 83.27 9.64 488 280840 81859 90265260
Opsoclonus myoclonus 83.25 9.64 28 281300 145 90346974
Disorientation 82.74 9.64 313 281015 43801 90303318
Eating disorder 82.35 9.64 232 281096 27841 90319278
Arterial occlusive disease 81.49 9.64 142 281186 12304 90334815
Liver function test increased 81.20 9.64 86 281242 84769 90262350
Paranoia 80.30 9.64 144 281184 12764 90334355
Sensory loss 80.20 9.64 175 281153 17900 90329219
Sinus congestion 78.85 9.64 225 281103 27199 90319920
Premature delivery 78.42 9.64 13 281315 38749 90308370
Hyperreflexia 78.35 9.64 100 281228 6557 90340562
Platelet count decreased 78.27 9.64 195 281133 136774 90210345
Hemiplegia 78.10 9.64 162 281166 15998 90331121
Restlessness 77.68 9.64 266 281062 35454 90311665
Dysarthria 77.41 9.64 355 280973 54127 90292992
Aphasia 77.21 9.64 300 281028 42512 90304607
Adverse event 77.03 9.64 155 281173 117263 90229856
Intervertebral discitis 76.81 9.64 82 281246 4438 90342681
Taste disorder 76.78 9.64 48 281280 61498 90285621
Gangrene 76.74 9.64 141 281187 12735 90334384
Colitis microscopic 76.59 9.64 130 281198 11029 90336090
Septic shock 76.46 9.64 89 281239 84071 90263048
White blood cell count abnormal 76.41 9.64 105 281223 7399 90339720
Hyperaesthesia 73.88 9.64 125 281203 10577 90336542
Intentional product misuse 73.83 9.64 504 280824 89100 90258019
Palpitations 72.81 9.64 696 280632 136032 90211087
Urinary retention 72.61 9.64 270 281058 37474 90309645
Neutrophil count decreased 71.28 9.64 70 281258 71462 90275657
Motor dysfunction 70.80 9.64 173 281155 19057 90328062
Musculoskeletal pain 70.29 9.64 283 281045 170968 90176151
Muscle twitching 70.00 9.64 199 281129 24003 90323116
Dissociation 68.44 9.64 94 281234 6621 90340498
Cystitis 67.85 9.64 396 280932 66322 90280797
Pulmonary malformation 67.51 9.64 30 281298 360 90346759
Dyspepsia 67.33 9.64 351 280977 197809 90149310
Night sweats 67.01 9.64 192 281136 128574 90218545
Lower limb fracture 66.91 9.64 100 281228 84913 90262206
Condition aggravated 66.76 9.64 1376 279952 594169 89752950
Drug tolerance decreased 66.75 9.64 10 281318 32120 90314999
Respiratory tract congestion 66.66 9.64 212 281116 27198 90319921
Onychomycosis 66.39 9.64 17 281311 37359 90309760
Lymphocytic oesophagitis 64.77 9.64 18 281310 41 90347078
Pregnancy 63.83 9.64 59 281269 61988 90285131
Drug-induced liver injury 62.93 9.64 115 281213 90203 90256916
Coeliac disease 62.61 9.64 30 281298 44580 90302539
Red blood cell sedimentation rate increased 62.28 9.64 100 281228 82495 90264624
Surgery 61.94 9.64 290 281038 44597 90302522
Bronchial neoplasm 61.67 9.64 31 281297 499 90346620
Mucosal inflammation 61.44 9.64 53 281275 57572 90289547
Aspartate aminotransferase increased 61.39 9.64 537 280791 102400 90244719
Influenza 61.34 9.64 682 280646 138582 90208537
Suspected suicide 61.14 9.64 108 281220 9460 90337659
Temperature intolerance 60.98 9.64 123 281205 11907 90335212
Cardiac failure 60.92 9.64 158 281170 109338 90237781
Dyspnoea 60.59 9.64 2182 279146 878773 89468346
Finger deformity 60.31 9.64 14 281314 32883 90314236
Bruxism 60.18 9.64 71 281257 4292 90342827
Acute kidney injury 60.08 9.64 670 280658 319717 90027402
Contusion 59.99 9.64 495 280833 250721 90096398
Urticaria 59.83 9.64 651 280677 312083 90035036
Knee arthroplasty 59.68 9.64 104 281224 83078 90264041
Concussion 59.35 9.64 116 281212 10975 90336144
Psychomotor hyperactivity 59.07 9.64 126 281202 12687 90334432
Osteoarthritis 58.75 9.64 361 280967 195369 90151750
Neuralgia 58.66 9.64 223 281105 31277 90315842
Nervousness 58.47 9.64 235 281093 33821 90313298
Drug ineffective for unapproved indication 57.99 9.64 380 280948 66264 90280855
Leukopenia 57.83 9.64 143 281185 100567 90246552
Exposure during pregnancy 57.73 9.64 468 280860 237942 90109177
Maternal exposure timing unspecified 57.36 9.64 3 281325 22480 90324639
Red blood cell sedimentation rate abnormal 56.59 9.64 5 281323 24199 90322920
Pneumonia 56.56 9.64 1528 279800 636531 89710588
Speech disorder 56.09 9.64 285 281043 45300 90301819
Bronchial haemorrhage 55.58 9.64 31 281297 622 90346497
Oesophageal spasm 55.40 9.64 60 281268 3301 90343818
Akathisia 55.26 9.64 113 281215 11046 90336073
Head injury 54.98 9.64 217 281111 30971 90316148
Major depression 54.97 9.64 106 281222 9929 90337190
Hostility 54.97 9.64 50 281278 2223 90344896
Laryngitis 54.94 9.64 46 281282 50707 90296412
Hypersomnia 54.63 9.64 169 281159 21362 90325757
Product administration interrupted 54.35 9.64 120 281208 12372 90334747
Swollen tongue 54.24 9.64 284 281044 45672 90301447
Mydriasis 54.15 9.64 134 281194 14878 90332241
Pre-existing condition improved 54.13 9.64 100 281228 9069 90338050
Extremity contracture 53.70 9.64 39 281289 1254 90345865
Cytomegalovirus infection 53.64 9.64 9 281319 26593 90320526
Epilepsy 53.50 9.64 109 281219 82097 90265022
Foot deformity 53.20 9.64 64 281264 59587 90287532
Oedema peripheral 52.95 9.64 528 280800 257387 90089732
Neck deformity 52.64 9.64 48 281280 2141 90344978
Complex regional pain syndrome 51.97 9.64 52 281276 2607 90344512
Coma blister 51.57 9.64 19 281309 134 90346985
Libido increased 51.52 9.64 43 281285 1701 90345418
Musculoskeletal stiffness 51.37 9.64 631 280697 295901 90051218
Impaired driving ability 50.60 9.64 71 281257 5102 90342017
Macular degeneration 49.64 9.64 28 281300 37942 90309177
Endometrial ablation 49.61 9.64 34 281294 995 90346124
Feeling of despair 49.01 9.64 55 281273 3149 90343970
Hypocalcaemia 48.89 9.64 36 281292 42332 90304787
Poisoning 48.86 9.64 130 281198 15087 90332032
Neck mass 48.37 9.64 60 281268 3822 90343297
Hemiparesis 47.95 9.64 211 281117 31608 90315511
Skin exfoliation 47.87 9.64 368 280960 67545 90279574
Cognitive disorder 47.76 9.64 374 280954 69033 90278086
Joint dislocation 47.53 9.64 41 281287 44541 90302578
Lung cyst 47.24 9.64 25 281303 450 90346669
Post cholecystectomy syndrome 47.00 9.64 31 281297 850 90346269
Migraine 46.79 9.64 841 280487 189551 90157568
Ulcer haemorrhage 46.70 9.64 12 281316 26309 90320810
Vomiting 46.51 9.64 2937 278391 785356 89561763
Sneezing 46.49 9.64 200 281128 29669 90317450
Exostosis 46.34 9.64 58 281270 53076 90294043
Intervertebral disc protrusion 46.16 9.64 187 281141 27009 90320110
Memory impairment 45.94 9.64 864 280464 196380 90150739
Apathy 45.73 9.64 104 281224 10936 90336183
Rebound nasal congestion 45.24 9.64 13 281315 35 90347084
Respiratory tract malformation 44.78 9.64 18 281310 165 90346954
Bipolar disorder 44.51 9.64 91 281237 8894 90338225
Erythema 44.31 9.64 476 280852 228770 90118349
Decompression sickness 44.28 9.64 16 281312 106 90347013
Middle insomnia 43.92 9.64 133 281195 16618 90330501
Ascites 43.89 9.64 50 281278 47690 90299429
Walking aid user 43.86 9.64 28 281300 35478 90311641
Hypertension 43.59 9.64 1084 280244 456448 89890671
Demyelination 43.39 9.64 85 281243 8055 90339064
Delusion 43.19 9.64 117 281211 13723 90333396
Sacroiliitis 42.91 9.64 59 281269 4160 90342959
Renal impairment 42.75 9.64 175 281153 105246 90241873
Rheumatoid nodule 42.54 9.64 6 281322 20160 90326959
Psychotic disorder 42.53 9.64 201 281127 31029 90316090
Rapid eye movements sleep abnormal 42.35 9.64 16 281312 122 90346997
Joint noise 42.24 9.64 66 281262 5224 90341895
Rubber sensitivity 42.20 9.64 48 281280 2789 90344330
Tachyphrenia 42.18 9.64 38 281290 1668 90345451
Therapy non-responder 42.13 9.64 250 281078 136454 90210665
Metabolic surgery 42.05 9.64 37 281291 1574 90345545
Ankle fracture 41.96 9.64 149 281179 20221 90326898
Porphyria acute 41.26 9.64 4 281324 17971 90329148
Decreased interest 40.92 9.64 59 281269 4348 90342771
Normal newborn 40.78 9.64 11 281317 23351 90323768
Blood immunoglobulin A increased 40.76 9.64 33 281295 1250 90345869
Blood alkaline phosphatase increased 40.53 9.64 272 281056 47807 90299312
Frequent bowel movements 40.10 9.64 72 281256 56863 90290256
Formication 39.97 9.64 61 281267 4730 90342389
Muscle spasticity 39.44 9.64 215 281113 35107 90312012
Product quality issue 39.30 9.64 121 281207 79204 90267915
Bone density abnormal 39.28 9.64 56 281272 4084 90343035
Emotional disorder 39.25 9.64 119 281209 14878 90332241
Neutropenic sepsis 39.18 9.64 5 281323 18125 90328994
Libido decreased 38.63 9.64 47 281281 2935 90344184
Galactorrhoea 38.30 9.64 59 281269 4613 90342506
Anorgasmia 38.24 9.64 25 281303 675 90346444
Urinary incontinence 38.21 9.64 223 281105 37343 90309776
Psoriasis 38.20 9.64 658 280670 147096 90200023
Pruritus 38.09 9.64 1337 279991 540188 89806931
Sensitivity to weather change 38.07 9.64 85 281243 8829 90338290
Autonomic nervous system imbalance 37.76 9.64 50 281278 3400 90343719
Product use in unapproved indication 37.56 9.64 777 280551 335459 90011660
Back injury 37.50 9.64 54 281274 46568 90300551
Neuropathy peripheral 37.25 9.64 615 280713 136355 90210764
Urinary tract infection 37.20 9.64 1226 280102 304406 90042713
Nasopharyngitis 37.03 9.64 971 280357 406133 89940986
Homicidal ideation 37.00 9.64 36 281292 1744 90345375
Clonus 36.86 9.64 65 281263 5685 90341434
Myoclonus 36.77 9.64 137 281191 19031 90328088
Product tampering 36.76 9.64 21 281307 442 90346677
Hypoventilation 36.74 9.64 62 281266 5234 90341885
Poor quality sleep 36.65 9.64 163 281165 24530 90322589
Bone marrow failure 36.38 9.64 28 281300 32193 90314926
Hepatic cirrhosis 36.16 9.64 90 281238 63163 90283956
Adverse reaction 35.93 9.64 24 281304 29688 90317431
Tearfulness 35.91 9.64 58 281270 4722 90342397
Hallucination, auditory 35.64 9.64 120 281208 15855 90331264
Dysphonia 35.50 9.64 325 281003 62759 90284360
Anovulatory cycle 35.48 9.64 15 281313 158 90346961
Pleural effusion 35.47 9.64 203 281125 111788 90235331
Multiple organ dysfunction syndrome 35.46 9.64 102 281226 68234 90278885
Hyponatraemia 35.00 9.64 596 280732 132942 90214177
Prescribed overdose 34.80 9.64 170 281158 97455 90249664
Hyperkalaemia 34.43 9.64 96 281232 64868 90282251
Vitamin B12 increased 34.39 9.64 35 281293 1791 90345328
Morbid thoughts 34.21 9.64 24 281304 730 90346389
Postictal psychosis 33.77 9.64 13 281315 105 90347014
Spinal disorder 33.75 9.64 96 281232 11583 90335536
Colitis ulcerative 33.49 9.64 87 281241 60179 90286940
Neoplasm progression 33.40 9.64 54 281274 44432 90302687
Drug screen positive 33.00 9.64 49 281279 3708 90343411
Depressive symptom 32.92 9.64 59 281269 5226 90341893
Asphyxia 32.92 9.64 70 281258 7033 90340086
Loss of libido 32.92 9.64 30 281298 1337 90345782
Thunderclap headache 32.77 9.64 18 281310 350 90346769
Psychotic disorder due to a general medical condition 32.72 9.64 16 281312 242 90346877
Blood creatinine increased 32.53 9.64 183 281145 101203 90245916
Thrombotic microangiopathy 32.47 9.64 5 281323 15738 90331381
Angina pectoris 32.09 9.64 220 281108 38940 90308179
Cataplexy 32.08 9.64 31 281297 1489 90345630
Drug reaction with eosinophilia and systemic symptoms 32.01 9.64 52 281276 42706 90304413
Therapeutic response changed 31.91 9.64 29 281299 1288 90345831
Blood calcium decreased 31.88 9.64 28 281300 30154 90316965
Dactylitis 31.87 9.64 49 281279 3824 90343295
Granulocyte count increased 31.84 9.64 31 281297 1503 90345616
Hypnopompic hallucination 31.64 9.64 11 281317 64 90347055
Bronchial disorder 31.57 9.64 31 281297 1519 90345600
Post-traumatic neck syndrome 31.55 9.64 39 281289 2475 90344644
Road traffic accident 31.50 9.64 200 281128 107426 90239693
Infusion site reaction 31.34 9.64 10 281318 19029 90328090
Antinuclear antibody negative 31.15 9.64 16 281312 270 90346849
Proctitis 31.13 9.64 5 281323 15254 90331865
Depression suicidal 31.05 9.64 35 281293 2014 90345105
Tension 30.89 9.64 47 281281 3635 90343484
Rhinorrhoea 30.83 9.64 414 280914 87902 90259217
Palmar-plantar erythrodysaesthesia syndrome 30.82 9.64 25 281303 27998 90319121
Exposure via breast milk 30.82 9.64 37 281291 2278 90344841
Rectal haemorrhage 30.72 9.64 142 281186 82602 90264517
Spinal operation 30.63 9.64 85 281243 10111 90337008
Pulmonary eosinophilia 30.62 9.64 17 281311 338 90346781
Stiff person syndrome 30.36 9.64 19 281309 475 90346644
White blood cell count decreased 30.29 9.64 352 280976 166757 90180362
Stress 30.27 9.64 386 280942 81009 90266110
Haemoglobin decreased 30.20 9.64 339 280989 161617 90185502
Prescribed underdose 30.12 9.64 125 281203 74894 90272225
Female genital tract fistula 30.10 9.64 9 281319 17859 90329260
Osteoporosis 30.02 9.64 176 281152 96355 90250764
Death 29.88 9.64 1137 280191 455414 89891705
Aspartate aminotransferase 29.87 9.64 22 281306 723 90346396
Phagophobia 29.86 9.64 10 281318 51 90347068
Agranulocytosis 29.70 9.64 39 281289 34963 90312156
Rheumatoid factor increased 29.62 9.64 37 281291 2374 90344745
Swelling face 29.50 9.64 384 280944 80968 90266151
Cytokine release syndrome 29.49 9.64 26 281302 27947 90319172
Telangiectasia congenital 29.49 9.64 8 281320 16 90347103
Antidepressant discontinuation syndrome 29.40 9.64 13 281315 154 90346965
Autonomic dysreflexia 29.29 9.64 17 281311 369 90346750
Progressive multifocal leukoencephalopathy 29.29 9.64 111 281217 15544 90331575
Bezoar 28.97 9.64 39 281289 2695 90344424
Adulterated product 28.97 9.64 17 281311 377 90346742
Decreased appetite 28.95 9.64 919 280409 375621 89971498
Transplant rejection 28.87 9.64 3 281325 12755 90334364
Sternal fracture 28.80 9.64 40 281288 2847 90344272
Arteriosclerosis coronary artery 28.79 9.64 80 281248 9523 90337596
Oesophageal pain 28.76 9.64 50 281278 4324 90342795
Priapism 28.68 9.64 12 281316 123 90346996
Conversion disorder 28.08 9.64 34 281294 2112 90345007
Coombs positive haemolytic anaemia 28.00 9.64 18 281310 472 90346647
Aplastic anaemia 27.86 9.64 4 281324 13265 90333854
Chronic idiopathic pain syndrome 27.71 9.64 10 281318 66 90347053
Skin necrosis 27.70 9.64 9 281319 16932 90330187
Overdose 27.68 9.64 663 280665 157046 90190073
Gastric banding 27.64 9.64 11 281317 98 90347021
Glomerular filtration rate increased 27.55 9.64 33 281295 2027 90345092
Fear 27.19 9.64 113 281215 16509 90330610
Soft tissue injury 27.14 9.64 33 281295 2059 90345060
Rib fracture 26.93 9.64 157 281171 26278 90320841
Rash maculo-papular 26.87 9.64 54 281274 40879 90306240
Gastrostomy 26.83 9.64 22 281306 849 90346270
White blood cells urine positive 26.68 9.64 61 281267 6437 90340682
Corneal reflex decreased 26.67 9.64 15 281313 306 90346813
Sepsis 26.64 9.64 395 280933 179419 90167700
Metastases to bone 26.53 9.64 24 281304 25481 90321638
Dystonia 26.47 9.64 113 281215 16706 90330413
Mental impairment 26.05 9.64 112 281216 16608 90330511
Extrapyramidal disorder 26.02 9.64 110 281218 16193 90330926
Alcoholism 26.01 9.64 30 281298 1770 90345349
Increased appetite 25.92 9.64 88 281240 11677 90335442
Haematotoxicity 25.81 9.64 4 281324 12531 90334588
Food aversion 25.57 9.64 26 281302 1329 90345790
Interstitial lung disease 25.56 9.64 136 281192 76269 90270850
Bradyphrenia 25.43 9.64 66 281262 7546 90339573
Diplopia 25.14 9.64 164 281164 28550 90318569
Device expulsion 25.11 9.64 56 281272 40830 90306289
Abdominal pain upper 25.07 9.64 814 280514 331860 90015259
Panic disorder 25.06 9.64 39 281289 3076 90344043
Bronchopulmonary aspergillosis 24.98 9.64 3 281325 11395 90335724
Burning sensation 24.92 9.64 304 281024 63148 90283971
Vitamin D deficiency 24.64 9.64 114 281214 17442 90329677
Burning mouth syndrome 24.62 9.64 18 281310 585 90346534
Tic 24.56 9.64 30 281298 1881 90345238
Sluggishness 24.53 9.64 56 281272 5903 90341216
Renal failure 24.51 9.64 274 281054 130733 90216386
Rash vesicular 24.39 9.64 13 281315 18184 90328935
Cerebrovascular accident 24.38 9.64 528 280800 123005 90224114
Lactation disorder 24.28 9.64 16 281312 438 90346681
Vitamin B12 deficiency 24.08 9.64 64 281264 7422 90339697
Somnambulism 23.97 9.64 57 281271 6171 90340948
Ear pain 23.89 9.64 95 281233 57607 90289512
Flat affect 23.86 9.64 28 281300 1683 90345436
Illness 23.38 9.64 371 280957 81598 90265521
Acute myeloid leukaemia 23.22 9.64 18 281310 20622 90326497
Vitamin B12 decreased 23.09 9.64 51 281277 5259 90341860
Amimia 23.03 9.64 9 281319 76 90347043
Toxic epidermal necrolysis 23.03 9.64 41 281287 32487 90314632
Back pain 22.90 9.64 1204 280124 315971 90031148
Ankylosing spondylitis 22.84 9.64 91 281237 13042 90334077
Drug resistance 22.82 9.64 37 281291 30412 90316707
Tubulointerstitial nephritis 22.80 9.64 27 281301 25316 90321803
Hepatic steatosis 22.68 9.64 194 281134 36751 90310368
Respiratory arrest 22.64 9.64 179 281149 33132 90313987
Movement disorder 22.58 9.64 161 281167 28858 90318261
Bipolar I disorder 22.52 9.64 30 281298 2052 90345067
False positive radioisotope investigation result 22.45 9.64 6 281322 11 90347108
Rhonchi 22.19 9.64 36 281292 2942 90344177
Poor sucking reflex 22.16 9.64 15 281313 430 90346689
Apnoea 22.15 9.64 72 281256 9342 90337777
Food allergy 22.02 9.64 28 281300 25450 90321669
Hyponatraemic encephalopathy 21.96 9.64 13 281315 293 90346826
Polyarthritis 21.95 9.64 15 281313 18335 90328784
Myofascial pain syndrome 21.93 9.64 36 281292 2971 90344148
Sleep talking 21.85 9.64 22 281306 1111 90346008
Miosis 21.83 9.64 72 281256 9412 90337707
Ear infection 21.81 9.64 127 281201 69648 90277471
Gambling disorder 21.78 9.64 23 281305 1229 90345890
Scoliosis 21.75 9.64 69 281259 8838 90338281
Meralgia paraesthetica 21.59 9.64 16 281312 531 90346588
Lactic acidosis 21.58 9.64 82 281246 50381 90296738
Dysphemia 21.38 9.64 36 281292 3034 90344085
Granulomatous liver disease 21.25 9.64 20 281308 929 90346190
Antidepressant drug level increased 21.22 9.64 14 281314 384 90346735
Aspergillus infection 21.09 9.64 4 281324 10819 90336300
Feeling drunk 21.03 9.64 46 281282 4712 90342407
Hyperacusis 20.97 9.64 34 281294 2777 90344342
Hypomagnesaemia 20.84 9.64 50 281278 35538 90311581
Throat irritation 20.76 9.64 237 281091 48458 90298661
Claustrophobia 20.68 9.64 23 281305 1304 90345815
Impulse-control disorder 20.67 9.64 20 281308 962 90346157
Hypokinesia 20.63 9.64 100 281228 15597 90331522
Rotator cuff syndrome 20.62 9.64 101 281227 15818 90331301
Ejection fraction decreased 20.54 9.64 31 281297 26222 90320897
Hypertensive urgency 20.45 9.64 17 281311 669 90346450
Impulsive behaviour 20.38 9.64 26 281302 1704 90345415
General symptom 20.38 9.64 10 281318 14658 90332461
Self-injurious ideation 20.26 9.64 36 281292 3167 90343952
Scar 20.17 9.64 98 281230 15297 90331822
Panic reaction 20.17 9.64 45 281283 4672 90342447
Tenosynovitis 20.13 9.64 10 281318 14557 90332562
Syncope 20.13 9.64 547 280781 132116 90215003
Hyperventilation 20.12 9.64 56 281272 6672 90340447
Carcinoid tumour pulmonary 20.05 9.64 15 281313 505 90346614
Second primary malignancy 19.87 9.64 4 281324 10374 90336745
Foetal death 19.82 9.64 21 281307 20702 90326417
Diabetes mellitus 19.79 9.64 297 281031 64578 90282541
Arthralgia 19.70 9.64 2116 279212 776406 89570713
Adverse drug reaction 19.56 9.64 250 281078 116451 90230668
Poisoning deliberate 19.53 9.64 102 281226 16384 90330735
Medical device site thrombosis 19.47 9.64 8 281320 78 90347041
Creatinine renal clearance decreased 19.40 9.64 18 281310 18881 90328238
Myositis 19.35 9.64 28 281300 24100 90323019
Areflexia 19.29 9.64 38 281290 3615 90343504
Eye pain 19.29 9.64 216 281112 43952 90303167
CYP3A4 polymorphism 19.29 9.64 8 281320 80 90347039
Clitoral engorgement 19.11 9.64 4 281324 0 90347119
Muscular weakness 19.07 9.64 804 280524 205862 90141257
Sedation 19.01 9.64 231 281097 47940 90299179
Genital pain 18.97 9.64 17 281311 741 90346378
Respiratory depression 18.89 9.64 97 281231 15478 90331641
Anxiety disorder 18.89 9.64 45 281283 4877 90342242
Metastases to central nervous system 18.86 9.64 16 281312 17526 90329593
Sciatic nerve injury 18.86 9.64 17 281311 747 90346372
Feelings of worthlessness 18.83 9.64 13 281315 385 90346734
Gastrointestinal haemorrhage 18.81 9.64 184 281144 90064 90257055
Hepatotoxicity 18.64 9.64 76 281252 45766 90301353
Gait disturbance 18.63 9.64 988 280340 259508 90087611
Distributive shock 18.55 9.64 36 281292 3388 90343731
Delirium 18.45 9.64 221 281107 104138 90242981
Blood glucose decreased 18.24 9.64 130 281198 23299 90323820
Febrile bone marrow aplasia 18.14 9.64 4 281324 9734 90337385
Feeling jittery 18.14 9.64 95 281233 15276 90331843
Metastases to liver 18.06 9.64 39 281289 28768 90318351
Myelodysplastic syndrome 18.04 9.64 23 281305 20880 90326239
Obsessive thoughts 17.98 9.64 15 281313 593 90346526
Pupillary reflex impaired 17.93 9.64 30 281298 2515 90344604
Dopamine transporter scintigraphy abnormal 17.86 9.64 8 281320 98 90347021
Bronchiectasis 17.83 9.64 26 281302 22304 90324815
Proteinuria 17.74 9.64 28 281300 23263 90323856
Emotional distress 17.74 9.64 183 281145 36479 90310640
Chest pain 17.72 9.64 811 280517 318834 90028285
Snoring 17.70 9.64 45 281283 5081 90342038
Dermatitis atopic 17.56 9.64 129 281199 23343 90323776
Dental caries 17.49 9.64 76 281252 11321 90335798
Trigger finger 17.45 9.64 45 281283 5125 90341994
Toxic skin eruption 17.44 9.64 14 281314 15760 90331359
Gastrointestinal toxicity 17.41 9.64 4 281324 9463 90337656
Immunodeficiency 17.38 9.64 72 281256 43162 90303957
Central nervous system lesion 17.37 9.64 77 281251 11569 90335550
Temperature regulation disorder 17.33 9.64 12 281316 14567 90332552
Musculoskeletal discomfort 17.24 9.64 118 281210 20873 90326246
Trigeminal neuralgia 17.20 9.64 39 281289 4092 90343027
Basal cell carcinoma 17.20 9.64 50 281278 33339 90313780
Alcohol abuse 17.12 9.64 26 281302 2007 90345112
Forced expiratory volume decreased 17.03 9.64 48 281280 5760 90341359
Overlap syndrome 17.00 9.64 3 281325 8545 90338574
Heat exhaustion 16.95 9.64 10 281318 224 90346895
Drug eruption 16.84 9.64 55 281273 35352 90311767
Bacteraemia 16.81 9.64 27 281301 22273 90324846
Liver function test abnormal 16.79 9.64 236 281092 50609 90296510
Suicidal behaviour 16.77 9.64 31 281297 2813 90344306
Drug ineffective 16.67 9.64 3927 277401 1380371 88966748
Mental status changes 16.66 9.64 212 281116 44467 90302652
Nasal septum deviation 16.58 9.64 25 281303 1918 90345201
Biliary colic 16.52 9.64 38 281290 4025 90343094
Gun shot wound 16.48 9.64 8 281320 119 90347000
Total cholesterol/HDL ratio abnormal 16.29 9.64 7 281321 77 90347042
Anal incontinence 16.28 9.64 96 281232 16134 90330985
Naevus flammeus 16.24 9.64 8 281320 123 90346996
Vaginal discharge 16.20 9.64 22 281306 19442 90327677
Persistent genital arousal disorder 16.15 9.64 15 281313 685 90346434
Intervertebral disc operation 16.12 9.64 17 281311 907 90346212
Urinary hesitation 15.99 9.64 28 281300 2435 90344684
Alcohol use 15.96 9.64 23 281305 1694 90345425
Breast cancer stage I 15.94 9.64 5 281323 9619 90337500
Gamma-glutamyltransferase increased 15.86 9.64 184 281144 37768 90309351
Mean cell haemoglobin concentration increased 15.80 9.64 14 281314 601 90346518
Occipital neuralgia 15.79 9.64 15 281313 705 90346414
Hypercalcaemia 15.73 9.64 54 281274 34186 90312933
Supraventricular tachyarrhythmia 15.61 9.64 7 281321 86 90347033
Metastases to lung 15.53 9.64 16 281312 15975 90331144
Ophthalmic vein thrombosis 15.52 9.64 11 281317 340 90346779
Tachyphylaxis 15.47 9.64 11 281317 342 90346777
Drug dependence 15.45 9.64 149 281179 29178 90317941
Pulmonary oedema 15.41 9.64 121 281207 61959 90285160
Spasmodic dysphonia 15.39 9.64 7 281321 89 90347030
Disseminated intravascular coagulation 15.38 9.64 27 281301 21511 90325608
Hepatobiliary scan abnormal 15.22 9.64 6 281322 52 90347067
Enterococcal infection 15.16 9.64 6 281322 9985 90337134
Sleep disorder 15.15 9.64 756 280572 197274 90149845
Therapeutic response unexpected 15.10 9.64 118 281210 21762 90325357
Impatience 15.09 9.64 12 281316 443 90346676
Cerebral infarction 15.08 9.64 38 281290 26558 90320561
Reaction to azo-dyes 15.01 9.64 5 281323 25 90347094
Antiphospholipid syndrome 14.96 9.64 26 281302 2248 90344871
Feeling of body temperature change 14.95 9.64 45 281283 5604 90341515
Tumour lysis syndrome 14.90 9.64 8 281320 11144 90335975
Oesophageal food impaction 14.85 9.64 10 281318 284 90346835
Vasculitis 14.84 9.64 30 281298 22663 90324456
Purple glove syndrome 14.82 9.64 9 281319 213 90346906
Vitamin D decreased 14.81 9.64 75 281253 11904 90335215
Breakthrough pain 14.80 9.64 20 281308 1387 90345732
Central pain syndrome 14.78 9.64 14 281314 656 90346463
Cyst 14.75 9.64 95 281233 16466 90330653
Metastases to lymph nodes 14.74 9.64 9 281319 11680 90335439
Spinal flattening 14.70 9.64 10 281318 289 90346830
Holmes-Adie pupil 14.69 9.64 5 281323 27 90347092
Psychotic behaviour 14.67 9.64 14 281314 662 90346457
Eye injury 14.59 9.64 8 281320 11012 90336107
Progressive multiple sclerosis 14.54 9.64 19 281309 1275 90345844
Congenital tricuspid valve atresia 14.47 9.64 6 281322 60 90347059
Labelled drug-drug interaction medication error 14.46 9.64 86 281242 14496 90332623
Anaphylactic shock 14.43 9.64 50 281278 31567 90315552
Cycloplegia 14.43 9.64 4 281324 9 90347110
Sexual dysfunction 14.38 9.64 40 281288 4764 90342355
Cytomegalovirus viraemia 14.37 9.64 3 281325 7583 90339536
Micturition urgency 14.36 9.64 71 281257 11162 90335957
Phobia of driving 14.33 9.64 3 281325 0 90347119
Sinus pain 14.33 9.64 43 281285 5346 90341773
Neuroleptic malignant syndrome 14.32 9.64 88 281240 15008 90332111
Hepatitis C antibody positive 14.31 9.64 7 281321 106 90347013
Laboratory test abnormal 14.28 9.64 74 281254 41780 90305339
Leukopenia neonatal 14.25 9.64 5 281323 30 90347089
Nasal polyps 14.25 9.64 8 281320 10872 90336247
Retching 14.16 9.64 105 281223 19054 90328065
Maternal exposure during breast feeding 14.12 9.64 47 281281 6173 90340946
Rales 14.09 9.64 17 281311 15810 90331309
Lung diffusion test decreased 13.99 9.64 15 281313 816 90346303
Enuresis 13.96 9.64 32 281296 3382 90343737
Hypnagogic hallucination 13.93 9.64 9 281319 238 90346881
Bradycardia 13.91 9.64 180 281148 83667 90263452
Menopausal symptoms 13.88 9.64 30 281298 3048 90344071
Respiratory tract infection 13.81 9.64 117 281211 58961 90288158
Pneumocystis jirovecii pneumonia 13.78 9.64 29 281299 21587 90325532
Diabetic retinal oedema 13.72 9.64 11 281317 411 90346708
Ligament injury 13.72 9.64 17 281311 1082 90346037
Nephrotic syndrome 13.70 9.64 3 281325 7336 90339783
Intrusive thoughts 13.67 9.64 11 281317 413 90346706
Knee operation 13.66 9.64 50 281278 6886 90340233
Food craving 13.61 9.64 23 281305 1944 90345175
Drug metabolising enzyme decreased 13.61 9.64 4 281324 12 90347107
Craniocerebral injury 13.58 9.64 31 281297 3267 90343852
Dysstasia 13.56 9.64 128 281200 24924 90322195
Throat clearing 13.52 9.64 34 281294 3813 90343306
Dysuria 13.46 9.64 184 281144 39217 90307902
Rash erythematous 13.46 9.64 133 281195 64971 90282148
Paranasal sinus inflammation 13.42 9.64 13 281315 626 90346493
Dysgraphia 13.41 9.64 33 281295 3650 90343469
Drug withdrawal syndrome neonatal 13.32 9.64 25 281303 2294 90344825
Sleep-related eating disorder 13.29 9.64 16 281312 988 90346131
Hysterectomy 13.26 9.64 71 281257 11513 90335606
Radiation fibrosis 13.25 9.64 5 281323 38 90347081
Nail avulsion 13.23 9.64 10 281318 342 90346777
Pseudomonas infection 13.20 9.64 16 281312 14849 90332270
Exposure via ingestion 13.20 9.64 27 281301 2640 90344479
Cushingoid 13.11 9.64 8 281320 10387 90336732
Respiratory failure 13.09 9.64 274 281054 118144 90228975
Bladder spasm 13.08 9.64 23 281305 2007 90345112
Haemoptysis 13.08 9.64 56 281272 33264 90313855
Pulmonary toxicity 13.04 9.64 10 281318 11521 90335598
Intervertebral disc degeneration 12.96 9.64 95 281233 17179 90329940
Impaired quality of life 12.90 9.64 119 281209 23025 90324094
Fungal infection 12.89 9.64 195 281133 42466 90304653
Therapy interrupted 12.89 9.64 223 281105 49885 90297234
Shock 12.80 9.64 46 281282 28732 90318387
Pulse abnormal 12.75 9.64 29 281299 3050 90344069
Cardiotoxicity 12.73 9.64 10 281318 11379 90335740
Persistent postural-perceptual dizziness 12.72 9.64 4 281324 16 90347103
Medical device site abscess 12.68 9.64 8 281320 203 90346916
Immobilisation prolonged 12.66 9.64 7 281321 138 90346981
Blood prolactin increased 12.63 9.64 32 281296 3605 90343514
Therapy cessation 12.50 9.64 170 281158 36191 90310928
Diaphragmatic paralysis 12.49 9.64 13 281315 683 90346436
Self esteem decreased 12.47 9.64 14 281314 802 90346317
Nephrolithiasis 12.46 9.64 218 281110 48867 90298252
Neuropsychiatric symptoms 12.41 9.64 13 281315 688 90346431
Uraemic encephalopathy 12.37 9.64 9 281319 290 90346829
Iritis 12.35 9.64 32 281296 3654 90343465
Oesophageal obstruction 12.32 9.64 13 281315 694 90346425
Lymphoedema 12.31 9.64 79 281249 13674 90333445
Parosmia 12.31 9.64 49 281279 7020 90340099
Drug tolerance 12.31 9.64 23 281305 17893 90329226
Blood uric acid increased 12.31 9.64 52 281276 7652 90339467
Serum serotonin increased 12.30 9.64 8 281320 214 90346905
Polyneuropathy 12.28 9.64 26 281302 19315 90327804
Spondyloarthropathy 12.27 9.64 17 281311 1207 90345912
Unresponsive to stimuli 12.21 9.64 176 281152 37945 90309174
Skin toxicity 12.20 9.64 3 281325 6776 90340343
Medical device site cellulitis 12.17 9.64 8 281320 218 90346901
Melaena 12.16 9.64 61 281267 34736 90312383
Electrocardiogram repolarisation abnormality 12.16 9.64 18 281310 1358 90345761
Negative thoughts 12.16 9.64 16 281312 1081 90346038
Frostbite 12.11 9.64 8 281320 220 90346899
Haemodialysis 12.10 9.64 6 281322 8741 90338378
Loose tooth 12.04 9.64 32 281296 3711 90343408
Lung neoplasm malignant 12.04 9.64 37 281291 24236 90322883
Foot fracture 12.03 9.64 131 281197 26475 90320644
Emotional poverty 12.02 9.64 10 281318 394 90346725
Adiposis dolorosa 11.98 9.64 9 281319 305 90346814
Alveolar bone resorption 11.97 9.64 5 281323 51 90347068
Meniscus injury 11.94 9.64 54 281274 8183 90338936
Generalised tonic-clonic seizure 11.92 9.64 163 281165 34740 90312379
Thirst 11.87 9.64 89 281239 16206 90330913
Blood lactate dehydrogenase increased 11.84 9.64 41 281287 25891 90321228
Mitochondrial encephalomyopathy 11.80 9.64 6 281322 99 90347020
Accommodation disorder 11.80 9.64 10 281318 404 90346715
Polyglandular autoimmune syndrome type II 11.80 9.64 5 281323 53 90347066
Blood catecholamines increased 11.80 9.64 5 281323 53 90347066
Tongue movement disturbance 11.78 9.64 10 281318 405 90346714
Pyometra 11.70 9.64 6 281322 101 90347018
Diabetic neuropathy 11.69 9.64 36 281292 4538 90342581
Aortic valve calcification 11.66 9.64 12 281316 622 90346497
Epstein-Barr virus infection 11.66 9.64 9 281319 10335 90336784
Fractured coccyx 11.61 9.64 17 281311 1270 90345849
Tendinous contracture 11.55 9.64 7 281321 165 90346954
Transfusion 11.54 9.64 23 281305 17465 90329654
Economic problem 11.53 9.64 29 281299 3252 90343867
Generalised anxiety disorder 11.51 9.64 26 281302 2721 90344398
Herpes simplex reactivation 11.51 9.64 15 281313 1004 90346115
Foot amputation 11.49 9.64 9 281319 325 90346794
Myalgia 11.48 9.64 659 280669 174466 90172653
Alcohol poisoning 11.47 9.64 21 281307 1891 90345228
Cold sweat 11.47 9.64 79 281249 14002 90333117
Cytopenia 11.47 9.64 23 281305 17426 90329693
Joint ankylosis 11.45 9.64 17 281311 1286 90345833
Loss of control of legs 11.45 9.64 18 281310 1432 90345687
Cholecystectomy 11.45 9.64 69 281259 11686 90335433
Dental restoration failure 11.42 9.64 16 281312 1148 90345971
Acute respiratory distress syndrome 11.39 9.64 48 281280 28638 90318481
Haemophagocytic lymphohistiocytosis 11.39 9.64 19 281309 15440 90331679
Bronchitis 11.32 9.64 582 280746 152345 90194774
Product physical issue 11.31 9.64 41 281287 5619 90341500
Muscle tightness 11.31 9.64 76 281252 13363 90333756
Drug screen negative 11.30 9.64 9 281319 333 90346786
Ventricular hypoplasia 11.29 9.64 7 281321 172 90346947
Hypoalbuminaemia 11.29 9.64 20 281308 15877 90331242
Multiple-drug resistance 11.27 9.64 5 281323 7771 90339348
Vitamin C decreased 11.25 9.64 5 281323 60 90347059
Premature labour 11.25 9.64 15 281313 13361 90333758
Haemoglobin urine present 11.24 9.64 13 281315 769 90346350
Chronic inflammatory demyelinating polyradiculoneuropathy 11.19 9.64 15 281313 1032 90346087
Hypophosphataemia 11.18 9.64 18 281310 14836 90332283
Aphonia 11.18 9.64 71 281257 12248 90334871
Phonophobia 11.16 9.64 10 281318 436 90346683
Feeling guilty 11.14 9.64 12 281316 656 90346463
Upper respiratory tract infection 11.13 9.64 308 281020 128010 90219109
Blood potassium decreased 11.07 9.64 209 281119 47518 90299601
Cranial nerve decompression 11.06 9.64 3 281325 6 90347113
Incomplete spinal fusion 11.06 9.64 3 281325 6 90347113
Duplicate therapy error 11.05 9.64 6 281322 114 90347005
Oliguria 11.05 9.64 10 281318 10614 90336505
Aspartate aminotransferase abnormal 11.02 9.64 25 281303 2624 90344495
Colitis 10.93 9.64 152 281176 69790 90277329
Brain hypoxia 10.89 9.64 11 281317 558 90346561
Cataract 10.86 9.64 297 281031 71795 90275324
Oral candidiasis 10.83 9.64 65 281263 35390 90311729
Product prescribing error 10.80 9.64 142 281186 30003 90317116
Social avoidant behaviour 10.80 9.64 29 281299 3384 90343735
Toothache 10.77 9.64 111 281217 22119 90325000
Pain 10.77 9.64 3353 277975 992988 89354131
Restless arm syndrome 10.76 9.64 5 281323 67 90347052
Psychomotor skills impaired 10.74 9.64 26 281302 2846 90344273
Narcolepsy 10.72 9.64 18 281310 1514 90345605
Blood sodium decreased 10.71 9.64 132 281196 27481 90319638
Blunted affect 10.70 9.64 8 281320 269 90346850
Euphoric mood 10.66 9.64 39 281289 5370 90341749
Sciatic nerve neuropathy 10.65 9.64 10 281318 463 90346656
Epistaxis 10.62 9.64 193 281135 84932 90262187
Product selection error 10.60 9.64 8 281320 273 90346846
Communication disorder 10.58 9.64 28 281300 3238 90343881
Sedation complication 10.57 9.64 23 281305 16921 90330198
Psychiatric symptom 10.57 9.64 47 281281 7071 90340048
Daydreaming 10.55 9.64 10 281318 469 90346650
Lateral medullary syndrome 10.46 9.64 3 281325 8 90347111
Accidental death 10.45 9.64 21 281307 2027 90345092
Spinal osteoarthritis 10.44 9.64 98 281230 19050 90328069
Paralogism 10.42 9.64 4 281324 32 90347087
Electric shock sensation 10.39 9.64 18 281310 1552 90345567
Schizophrenia 10.38 9.64 19 281309 14895 90332224
Cerebral disorder 10.35 9.64 40 281288 5654 90341465
Injection site pain 10.33 9.64 648 280680 173051 90174068
Hepatitis A antibody positive 10.32 9.64 5 281323 74 90347045
Instillation site inflammation 10.32 9.64 4 281324 33 90347086
Abdominal pain 10.32 9.64 1073 280255 394648 89952471
Wrong patient 10.29 9.64 13 281315 844 90346275
Nerve compression 10.28 9.64 62 281266 10504 90336615
Angle closure glaucoma 10.25 9.64 25 281303 2750 90344369
Paraesthesia oral 10.23 9.64 57 281271 31602 90315517
Clumsiness 10.18 9.64 24 281304 2583 90344536
Caesarean section 10.18 9.64 27 281301 18550 90328569
Incontinence 10.14 9.64 74 281254 13361 90333758
Urine odour abnormal 10.14 9.64 47 281281 7197 90339922
Multiple lentigines syndrome 10.12 9.64 7 281321 208 90346911
Limb deformity 9.99 9.64 32 281296 4120 90342999
Angioedema 9.98 9.64 268 281060 64608 90282511
Nasal congestion 9.97 9.64 334 280994 83080 90264039
Muscle atrophy 9.97 9.64 52 281276 8349 90338770
Junctional ectopic tachycardia 9.95 9.64 7 281321 214 90346905
Impaired gastric emptying 9.93 9.64 71 281257 12738 90334381
Hepatitis 9.92 9.64 157 281171 70582 90276537
Labelled drug-food interaction issue 9.92 9.64 4 281324 37 90347082
Heart rate increased 9.91 9.64 437 280891 112465 90234654
Deformity 9.88 9.64 14 281314 12156 90334963
Cartilage injury 9.87 9.64 21 281307 2110 90345009
Cardiac failure congestive 9.87 9.64 232 281096 98462 90248657
Dissociative disorder 9.87 9.64 11 281317 625 90346494
Frontotemporal dementia 9.86 9.64 9 281319 402 90346717
Fumbling 9.84 9.64 6 281322 143 90346976
Forced vital capacity decreased 9.83 9.64 15 281313 1163 90345956
Jaundice cholestatic 9.81 9.64 10 281318 10033 90337086
Inadequate analgesia 9.81 9.64 27 281301 3197 90343922
Neurodermatitis 9.80 9.64 26 281302 3012 90344107
Pulseless electrical activity 9.78 9.64 8 281320 8924 90338195
Compulsive shopping 9.77 9.64 12 281316 757 90346362
Diabetic microangiopathy 9.75 9.64 3 281325 11 90347108
Hyperprolactinaemia 9.74 9.64 38 281290 5395 90341724
Abortion spontaneous 9.71 9.64 228 281100 53828 90293291
Neutropenia neonatal 9.70 9.64 5 281323 85 90347034
Trismus 9.70 9.64 35 281293 4786 90342333
Eating disorder symptom 9.69 9.64 6 281322 147 90346972
Amenorrhoea 9.69 9.64 66 281262 11656 90335463
Blood bicarbonate increased 9.66 9.64 13 281315 898 90346221
Benign vaginal neoplasm 9.65 9.64 5 281323 86 90347033

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug withdrawal syndrome 1278.10 11.27 707 89607 20842 42510179
Dysphoria 1168.47 11.27 370 89944 2410 42528611
Affect lability 1119.86 11.27 393 89921 3651 42527370
Suicidal ideation 802.67 11.27 726 89588 47435 42483586
Irritability 630.54 11.27 503 89811 27625 42503396
Hyperhidrosis 556.62 11.27 814 89500 89698 42441323
Sensory disturbance 524.88 11.27 269 90045 6754 42524267
Nightmare 515.62 11.27 426 89888 24586 42506435
Agitation 452.33 11.27 617 89697 63697 42467324
Insomnia 446.98 11.27 855 89459 117398 42413623
Paraesthesia 424.64 11.27 642 89672 72817 42458204
Completed suicide 406.46 11.27 731 89583 95734 42435287
Vertigo 391.39 11.27 421 89893 33926 42497095
Anxiety 362.18 11.27 785 89529 117775 42413246
Serotonin syndrome 323.29 11.27 333 89981 25512 42505509
Dizziness 262.70 11.27 1134 89180 248120 42282901
Confusional state 243.95 11.27 845 89469 166752 42364269
Tremor 235.61 11.27 587 89727 96342 42434679
Sedation 234.96 11.27 306 90008 30169 42500852
Hypomania 234.76 11.27 112 90202 2396 42528625
Nausea 219.20 11.27 1513 88801 395286 42135735
Mood swings 213.08 11.27 165 90149 8661 42522360
Lethargy 212.29 11.27 367 89947 46523 42484498
Tinnitus 172.81 11.27 257 90057 28681 42502340
Febrile neutropenia 168.30 11.27 92 90222 185611 42345410
Headache 164.06 11.27 965 89349 238404 42292617
Pyrexia 145.39 11.27 395 89919 393647 42137374
Suicide attempt 144.77 11.27 309 90005 45791 42485230
Fatigue 139.20 11.27 1471 88843 434170 42096851
Anaemia 114.85 11.27 266 90048 280012 42251009
Withdrawal syndrome 113.28 11.27 148 90166 14627 42516394
Anger 111.83 11.27 138 90176 12880 42518141
Affective disorder 103.36 11.27 92 90222 5868 42525153
Depression 100.72 11.27 485 89829 110878 42420143
Toxicity to various agents 98.00 11.27 824 89490 228312 42302709
Multiple organ dysfunction syndrome 95.48 11.27 43 90271 96992 42434029
Overdose 94.15 11.27 457 89857 104807 42426214
Feeling abnormal 92.83 11.27 342 89972 69444 42461577
Sleep disorder 92.22 11.27 267 90047 47828 42483193
Acute kidney injury 89.76 11.27 437 89877 366900 42164121
Fall 89.22 11.27 822 89492 233698 42297323
Nephrolithiasis 85.12 11.27 219 90095 36611 42494410
Disturbance in attention 83.36 11.27 191 90123 29675 42501346
Delusion of grandeur 82.72 11.27 52 90262 1944 42529077
Gastrointestinal tube insertion 82.50 11.27 47 90267 1463 42529558
Pancytopenia 82.14 11.27 77 90237 117666 42413355
Somnolence 81.52 11.27 545 89769 140560 42390461
Thrombocytopenia 79.94 11.27 178 90136 190101 42340920
Intentional self-injury 79.48 11.27 127 90187 15075 42515946
Reversible airways obstruction 78.85 11.27 34 90280 569 42530452
Sepsis 77.73 11.27 194 90120 199140 42331881
Rhinalgia 76.32 11.27 48 90266 1796 42529225
Hallucination, auditory 74.75 11.27 122 90192 14742 42516279
Memory impairment 71.77 11.27 252 90062 49970 42481051
Myelosuppression 69.51 11.27 4 90310 40457 42490564
Dementia 69.37 11.27 125 90189 16355 42514666
Sexual dysfunction 65.04 11.27 76 90238 6699 42524322
Pleural effusion 64.91 11.27 66 90248 97100 42433921
Dyspnoea 64.80 11.27 613 89701 442008 42089013
Lymphocyte count abnormal 61.94 11.27 45 90269 2142 42528879
Psychotic disorder 59.73 11.27 166 90148 29042 42501979
Intentional overdose 59.28 11.27 241 90073 51215 42479806
Neutropenia 58.56 11.27 221 90093 199210 42331811
Ascites 57.51 11.27 24 90290 56654 42474367
Delirium 56.60 11.27 241 90073 52278 42478743
Death 55.52 11.27 686 89628 470499 42060522
Antidepressant drug level above therapeutic 54.94 11.27 21 90293 253 42530768
Myoclonus 54.25 11.27 115 90199 16950 42514071
Disease progression 53.51 11.27 143 90171 143513 42387508
Undifferentiated connective tissue disease 52.19 11.27 16 90298 92 42530929
Balance disorder 51.62 11.27 219 90095 47426 42483595
Haemoglobin decreased 51.54 11.27 129 90185 132342 42398679
Blood creatinine increased 51.15 11.27 97 90217 109906 42421115
Analgesic drug level above therapeutic 51.09 11.27 21 90293 310 42530711
Malignant neoplasm progression 50.92 11.27 95 90219 108305 42422716
General physical health deterioration 49.48 11.27 160 90154 151086 42379935
Urinary retention 48.84 11.27 198 90116 42016 42489005
Aggression 48.63 11.27 204 90110 43959 42487062
Pneumonia 48.04 11.27 619 89695 421530 42109491
Schizophrenia 46.95 11.27 82 90232 10468 42520553
Gait disturbance 46.41 11.27 361 89953 97639 42433382
Neurodegenerative disorder 46.04 11.27 21 90293 404 42530617
Loss of consciousness 42.52 11.27 338 89976 92016 42439005
Abnormal dreams 41.74 11.27 68 90246 8203 42522818
Product used for unknown indication 41.70 11.27 28 90286 1173 42529848
Extrapyramidal disorder 40.42 11.27 100 90214 16312 42514709
Hepatic enzyme increased 40.32 11.27 198 90116 45586 42485435
Gastric bypass 40.23 11.27 17 90297 270 42530751
Pulmonary embolism 40.19 11.27 125 90189 119487 42411534
Renal impairment 39.34 11.27 112 90202 110116 42420905
Cytomegalovirus infection 39.24 11.27 10 90304 32296 42498725
Renal failure 39.15 11.27 164 90150 143562 42387459
Septic shock 39.07 11.27 85 90229 91587 42439434
Dissociation 38.80 11.27 44 90270 3754 42527267
Cardiac failure 38.55 11.27 108 90206 106748 42424273
Respiratory disorder neonatal 37.36 11.27 32 90282 1938 42529083
Bradyphrenia 36.19 11.27 50 90264 5212 42525809
C-reactive protein increased 36.18 11.27 49 90265 63511 42467510
Fibromyalgia 36.07 11.27 43 90271 3870 42527151
Feeling jittery 35.95 11.27 46 90268 4452 42526569
Inappropriate antidiuretic hormone secretion 35.80 11.27 96 90218 16445 42514576
Road traffic accident 35.62 11.27 105 90209 18988 42512033
Disorientation 35.42 11.27 162 90152 36227 42494794
Haemorrhage 35.18 11.27 46 90268 60517 42470504
Respiratory failure 35.02 11.27 146 90168 127986 42403035
Growth hormone deficiency 34.88 11.27 16 90298 312 42530709
Cytokine release syndrome 34.87 11.27 26 90288 44501 42486520
Hallucination 33.68 11.27 223 90091 57284 42473737
Mania 33.43 11.27 71 90243 10476 42520545
Post concussion syndrome 33.40 11.27 13 90301 165 42530856
Self esteem decreased 33.32 11.27 18 90296 504 42530517
Loss of control of legs 32.40 11.27 21 90293 828 42530193
Haemoptysis 32.39 11.27 30 90284 46137 42484884
Neuropathy peripheral 31.81 11.27 343 89971 101510 42429511
Seizure 30.98 11.27 391 89923 120170 42410851
Pain 30.81 11.27 707 89607 244141 42286880
Urinary hesitation 30.73 11.27 35 90279 3000 42528021
Rash maculo-papular 30.54 11.27 21 90293 37482 42493539
Ankylosing spondylitis 30.31 11.27 54 90260 7002 42524019
Drug reaction with eosinophilia and systemic symptoms 29.93 11.27 27 90287 42048 42488973
Disseminated intravascular coagulation 29.49 11.27 8 90306 24786 42506235
Tubulointerstitial nephritis 29.45 11.27 15 90299 31533 42499488
Toxic epidermal necrolysis 29.35 11.27 10 90304 26740 42504281
Substance dependence 29.34 11.27 18 90296 644 42530377
Platelet count decreased 29.20 11.27 173 90141 138408 42392613
Bone marrow failure 29.05 11.27 17 90297 33076 42497945
Depressed mood 28.91 11.27 112 90202 23272 42507749
Electric shock sensation 28.86 11.27 16 90298 472 42530549
Initial insomnia 28.78 11.27 39 90275 3991 42527030
Agranulocytosis 27.92 11.27 15 90299 30597 42500424
Hallucination, visual 27.91 11.27 103 90211 20917 42510104
Infection 27.43 11.27 133 90181 111935 42419086
Erythema 27.28 11.27 128 90186 108665 42422356
Major depression 26.72 11.27 44 90270 5354 42525667
Cardiogenic shock 26.40 11.27 22 90292 35618 42495403
Homicidal ideation 26.25 11.27 31 90283 2763 42528258
Bronchopulmonary aspergillosis 25.64 11.27 5 90309 19424 42511597
SARS-CoV-2 test positive 25.48 11.27 55 90259 8205 42522816
Haematochezia 25.04 11.27 54 90260 58382 42472639
Tumour lysis syndrome 24.93 11.27 8 90306 22223 42508798
Gastrointestinal injury 24.86 11.27 20 90294 1109 42529912
Panic attack 24.81 11.27 65 90249 10980 42520041
Condition aggravated 24.76 11.27 396 89918 260358 42270663
Bezoar 24.75 11.27 21 90293 1255 42529766
Snoring 24.73 11.27 36 90278 3937 42527084
Drug interaction 24.60 11.27 740 89574 266259 42264762
Ventricular fibrillation 24.35 11.27 17 90297 30106 42500915
Amnesia 24.34 11.27 122 90192 28315 42502706
Rash 24.22 11.27 427 89887 276527 42254494
Psoriatic arthropathy 24.18 11.27 111 90203 24856 42506165
Hypersomnia 24.10 11.27 77 90237 14541 42516480
Restlessness 23.99 11.27 124 90190 29125 42501896
Neonatal epileptic seizure 23.94 11.27 8 90306 63 42530958
Infusion related reaction 23.79 11.27 59 90255 60747 42470274
Thinking abnormal 23.62 11.27 49 90265 7112 42523909
Bacterial infection 23.53 11.27 15 90299 27864 42503157
White blood cell count decreased 23.15 11.27 138 90176 110258 42420763
Restless legs syndrome 23.06 11.27 58 90256 9556 42521465
Pericardial effusion 23.04 11.27 17 90297 29258 42501763
Abnormal behaviour 23.00 11.27 114 90200 26337 42504684
Metabolic acidosis 22.99 11.27 47 90267 51811 42479210
Prostate cancer 22.88 11.27 37 90277 44606 42486415
Convulsive threshold lowered 22.82 11.27 14 90300 501 42530520
Migraine 22.44 11.27 110 90204 25304 42505717
Complex regional pain syndrome 22.30 11.27 15 90299 630 42530391
Hepatitis E antibody positive 22.21 11.27 11 90303 256 42530765
Atrial fibrillation 22.20 11.27 189 90125 139404 42391617
Erectile dysfunction 22.11 11.27 108 90206 24805 42506216
Drug resistance 22.03 11.27 24 90290 34224 42496797
Yawning 21.94 11.27 16 90298 766 42530255
Coronary artery disease 21.91 11.27 51 90263 53669 42477352
Productive cough 21.81 11.27 48 90266 51519 42479502
Off label use 21.76 11.27 1119 89195 637216 41893805
Dissociative disorder 21.74 11.27 15 90299 657 42530364
Dystonia 21.67 11.27 68 90246 12722 42518299
Myasthenia gravis 21.62 11.27 4 90310 16133 42514888
Pulmonary alveolar haemorrhage 21.36 11.27 3 90311 14813 42516208
Cough 21.35 11.27 258 90056 177845 42353176
Mental disorder 21.19 11.27 85 90229 17944 42513077
Dyskinesia 21.08 11.27 108 90206 25282 42505739
Nephropathy toxic 20.86 11.27 5 90309 16833 42514188
Oedema peripheral 20.86 11.27 186 90128 135890 42395131
Intentional product use issue 20.78 11.27 80 90234 71753 42459268
Hepatitis E virus test positive 20.72 11.27 11 90303 297 42530724
Chest injury 20.15 11.27 22 90292 1800 42529221
Pneumonitis 20.07 11.27 36 90278 41682 42489339
Intentional product misuse 20.04 11.27 210 90104 61690 42469331
Gastrointestinal adenocarcinoma 19.94 11.27 7 90307 65 42530956
Respiratory depression 19.86 11.27 86 90228 18782 42512239
Interstitial lung disease 19.85 11.27 92 90222 78370 42452651
Liver function test abnormal 19.81 11.27 127 90187 32264 42498757
Myocardial infarction 19.67 11.27 168 90146 123841 42407180
Acute stress disorder 19.55 11.27 9 90305 177 42530844
Blood lactate dehydrogenase increased 19.44 11.27 16 90298 26065 42504956
Muscle spasticity 19.44 11.27 44 90270 6778 42524243
International normalised ratio increased 19.42 11.27 46 90268 48122 42482899
Bronchiectasis 19.31 11.27 7 90307 18012 42513009
Pulmonary fibrosis 19.12 11.27 17 90297 26664 42504357
Gout 18.79 11.27 19 90295 28036 42502985
Sleep-related eating disorder 18.78 11.27 11 90303 361 42530660
Hypoxia 18.75 11.27 80 90234 69706 42461315
Feeling guilty 18.73 11.27 11 90303 363 42530658
Hypertensive emergency 18.58 11.27 18 90296 1279 42529742
Somnambulism 18.50 11.27 29 90285 3386 42527635
Multiple sclerosis 18.40 11.27 46 90268 7552 42523469
Multiple sclerosis relapse 18.19 11.27 69 90245 14195 42516826
Orthostatic hypotension 18.17 11.27 119 90195 30451 42500570
Bipolar disorder 18.12 11.27 31 90283 3891 42527130
Cardiomegaly 18.10 11.27 77 90237 16689 42514332
Pneumocystis jirovecii pneumonia 18.10 11.27 16 90298 25165 42505856
Cholestasis 18.05 11.27 26 90288 32853 42498168
Paranoia 18.01 11.27 68 90246 13958 42517063
Sleep sex 17.87 11.27 4 90310 4 42531017
Paedophilia 17.87 11.27 4 90310 4 42531017
Respiratory distress 17.62 11.27 39 90275 41781 42489240
Haematuria 17.61 11.27 63 90251 57736 42473285
Hypokalaemia 17.61 11.27 85 90229 71636 42459385
Product administration interrupted 17.59 11.27 35 90279 4931 42526090
Neuroleptic malignant syndrome 17.59 11.27 91 90223 21381 42509640
Cardiac murmur 17.47 11.27 3 90311 12772 42518249
Acute myeloid leukaemia 17.42 11.27 13 90301 22243 42508778
Agitation neonatal 17.12 11.27 18 90296 1410 42529611
Blood phosphorus increased 17.00 11.27 3 90311 12522 42518499
Vasculitis 16.79 11.27 9 90305 18385 42512636
Angioedema 16.78 11.27 41 90273 42436 42488585
Forced expiratory flow decreased 16.64 11.27 8 90306 174 42530847
Compulsive shopping 16.61 11.27 11 90303 450 42530571
Gastrointestinal haemorrhage 16.59 11.27 130 90184 97596 42433425
Clonus 16.50 11.27 28 90286 3492 42527529
Hypocalcaemia 16.43 11.27 24 90290 30149 42500872
Mood altered 16.36 11.27 55 90259 10663 42520358
Appendicitis 16.18 11.27 12 90302 20601 42510420
Lung disorder 16.14 11.27 50 90264 47873 42483148
Colitis ulcerative 16.12 11.27 19 90295 26156 42504865
Alcoholism 16.03 11.27 25 90289 2905 42528116
Influenza like illness 16.01 11.27 119 90195 31721 42499300
Dehydration 15.99 11.27 208 90106 141559 42389462
Wheezing 15.85 11.27 61 90253 54720 42476301
Pre-existing condition improved 15.82 11.27 25 90289 2938 42528083
Drug screen false positive 15.79 11.27 14 90300 888 42530133
Libido decreased 15.79 11.27 34 90280 5064 42525957
Disease recurrence 15.78 11.27 24 90290 29654 42501367
Adenocarcinoma of appendix 15.72 11.27 7 90307 127 42530894
Myocardial depression 15.72 11.27 7 90307 127 42530894
Activated partial thromboplastin time prolonged 15.70 11.27 7 90307 15896 42515125
Pneumothorax 15.70 11.27 16 90298 23527 42507494
Rhinorrhoea 15.69 11.27 27 90287 31767 42499254
Delirium tremens 15.65 11.27 12 90302 620 42530401
Hypotension 15.61 11.27 421 89893 257210 42273811
Ventricular hypoplasia 15.57 11.27 6 90308 74 42530947
Lacunar stroke 15.54 11.27 9 90305 289 42530732
Posterior reversible encephalopathy syndrome 15.51 11.27 4 90310 12817 42518204
Acute myocardial infarction 15.43 11.27 67 90247 58098 42472923
Glabellar reflex abnormal 15.35 11.27 5 90309 36 42530985
Sleep disorder due to a general medical condition 15.27 11.27 9 90305 17444 42513577
Obstructive airways disorder 15.22 11.27 18 90296 24741 42506280
Hypoalbuminaemia 15.21 11.27 7 90307 15603 42515418
Deep vein thrombosis 15.19 11.27 98 90216 76859 42454162
Orgasm abnormal 15.05 11.27 7 90307 141 42530880
Lymphadenopathy 14.99 11.27 30 90284 33335 42497686
Hepatic cytolysis 14.96 11.27 21 90293 26823 42504198
Hyperbilirubinaemia 14.96 11.27 13 90301 20622 42510399
Multiple drug therapy 14.93 11.27 15 90299 1114 42529907
Cerebral infarction 14.90 11.27 27 90287 31142 42499879
Narcissistic personality disorder 14.88 11.27 4 90310 13 42531008
Urethral discharge 14.88 11.27 4 90310 13 42531008
Chronic idiopathic pain syndrome 14.87 11.27 7 90307 145 42530876
Psychomotor hyperactivity 14.80 11.27 54 90260 10904 42520117
Speech sound disorder 14.79 11.27 7 90307 147 42530874
Drug hypersensitivity 14.72 11.27 294 90020 99095 42431926
Aplastic anaemia 14.72 11.27 4 90310 12380 42518641
Colitis 14.70 11.27 50 90264 46522 42484499
Chills 14.66 11.27 128 90186 93938 42437083
Apathy 14.52 11.27 45 90269 8361 42522660
Neonatal hyponatraemia 14.51 11.27 6 90308 90 42530931
Drug screen positive 14.49 11.27 29 90285 4102 42526919
Bradycardia 14.38 11.27 114 90200 85370 42445651
Blood urea increased 14.30 11.27 30 90284 32763 42498258
Suicidal behaviour 14.27 11.27 17 90297 1529 42529492
Hypomagnesaemia 14.24 11.27 24 90290 28464 42502557
Hypophosphataemia 14.23 11.27 14 90300 20931 42510090
Pseudomonas infection 14.23 11.27 8 90306 15915 42515106
Wrong drug 14.21 11.27 7 90307 161 42530860
Hyperlipasaemia 14.06 11.27 11 90303 586 42530435
Norepinephrine increased 14.04 11.27 4 90310 17 42531004
Cytopenia 13.98 11.27 10 90304 17487 42513534
Neonatal asphyxia 13.95 11.27 10 90304 466 42530555
Graft versus host disease 13.89 11.27 5 90309 12920 42518101
Steatohepatitis 13.82 11.27 10 90304 473 42530548
Tardive dyskinesia 13.80 11.27 39 90275 6885 42524136
Oromandibular dystonia 13.75 11.27 11 90303 605 42530416
Tethered cord syndrome 13.68 11.27 4 90310 19 42531002
Homicide 13.68 11.27 13 90301 902 42530119
Acute encephalitis with refractory, repetitive partial seizures 13.49 11.27 5 90309 55 42530966
Cardiac failure acute 13.46 11.27 6 90308 13627 42517394
Anaphylactic reaction 13.42 11.27 46 90268 42697 42488324
Psychopathic personality 13.40 11.27 3 90311 3 42531018
Renal aplasia 13.40 11.27 12 90302 771 42530250
Panic disorder 13.40 11.27 15 90299 1262 42529759
Stomatitis 13.33 11.27 58 90256 50271 42480750
Surgery 13.30 11.27 73 90241 17543 42513478
Hypoaesthesia 13.26 11.27 219 90095 71244 42459777
Intervertebral disc degeneration 13.25 11.27 40 90274 7327 42523694
Loss of employment 13.24 11.27 10 90304 505 42530516
Epistaxis 13.24 11.27 85 90229 66741 42464280
Nodule 13.21 11.27 5 90309 12529 42518492
Cardiac failure congestive 13.11 11.27 117 90197 85485 42445536
Cytomegalovirus viraemia 13.02 11.27 3 90311 10374 42520647
Neutrophil count increased 12.95 11.27 79 90235 19725 42511296
Retrograde ejaculation 12.91 11.27 10 90304 525 42530496
Morbid thoughts 12.86 11.27 7 90307 199 42530822
Renal tubular necrosis 12.79 11.27 12 90302 18342 42512679
Reduced facial expression 12.76 11.27 16 90298 1517 42529504
Frequent bowel movements 12.69 11.27 16 90298 21391 42509630
Abulia 12.66 11.27 11 90303 679 42530342
Melaena 12.64 11.27 41 90273 38705 42492316
Rectal haemorrhage 12.64 11.27 58 90256 49548 42481473
Lung infiltration 12.54 11.27 7 90307 13982 42517039
Anaphylactic shock 12.52 11.27 19 90295 23498 42507523
Dysmetropsia 12.50 11.27 4 90310 27 42530994
Facial spasm 12.49 11.27 7 90307 211 42530810
Selective eating disorder 12.49 11.27 17 90297 1747 42529274
Axillary pain 12.49 11.27 9 90305 423 42530598
Staphylococcal bacteraemia 12.47 11.27 4 90310 11117 42519904
Full blood count abnormal 12.47 11.27 28 90286 29848 42501173
Dysstasia 12.45 11.27 61 90253 14025 42516996
Parkinsonism 12.42 11.27 50 90264 10573 42520448
Hyperphosphataemia 12.41 11.27 6 90308 12998 42518023
Thrombotic microangiopathy 12.41 11.27 8 90306 14774 42516247
Gambling disorder 12.40 11.27 17 90297 1759 42529262
Pulmonary pain 12.39 11.27 16 90298 1562 42529459
Alopecia 12.30 11.27 105 90209 29171 42501850
Device related infection 12.19 11.27 15 90299 20264 42510757
Toxic skin eruption 12.12 11.27 7 90307 13723 42517298
Bladder cancer 12.05 11.27 11 90303 17036 42513985
Autonomic dysreflexia 11.97 11.27 5 90309 77 42530944
Sudden cardiac death 11.96 11.27 26 90288 3898 42527123
Impaired driving ability 11.91 11.27 22 90292 2933 42528088
Lymphopenia 11.89 11.27 17 90297 21546 42509475
Muscle twitching 11.87 11.27 53 90261 11727 42519294
Genital pain 11.87 11.27 12 90302 898 42530123
Eosinophil count increased 11.85 11.27 4 90310 10759 42520262
Self-injurious ideation 11.74 11.27 17 90297 1851 42529170
Bacteraemia 11.70 11.27 22 90292 25018 42506003
Blue toe syndrome 11.69 11.27 6 90308 151 42530870
Lymphoma 11.68 11.27 8 90306 14313 42516708
Stress 11.68 11.27 51 90263 44161 42486860
Palmar-plantar erythrodysaesthesia syndrome 11.57 11.27 16 90298 20566 42510455
Second primary malignancy 11.56 11.27 3 90311 9572 42521449
Nervousness 11.54 11.27 58 90256 13474 42517547
Libido disorder 11.50 11.27 8 90306 355 42530666
Lactic acidosis 11.48 11.27 53 90261 45208 42485813
Asthma 11.47 11.27 81 90233 62233 42468788
Helplessness 11.47 11.27 5 90309 86 42530935
Hyperglycaemia 11.46 11.27 54 90260 45805 42485216
Prescribed overdose 11.44 11.27 56 90258 12871 42518150
Neutrophil count decreased 11.40 11.27 83 90231 63332 42467689
End stage renal disease 11.33 11.27 11 90303 16547 42514474
Neonatal tachypnoea 11.31 11.27 8 90306 365 42530656
Escherichia infection 11.28 11.27 5 90309 11391 42519630

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Serotonin syndrome 1179.37 10.01 1058 273562 58095 110256584
Completed suicide 1150.33 10.01 2116 272504 240265 110074414
Drug withdrawal syndrome 1097.34 10.01 843 273777 37211 110277468
Suicidal ideation 1020.20 10.01 1212 273408 92725 110221954
Hyperhidrosis 711.78 10.01 1490 273130 185808 110128871
Nightmare 505.80 10.01 551 274069 38312 110276367
Pemphigus 504.99 10.01 5 274615 214565 110100114
Affect lability 494.16 10.01 393 274227 18244 110296435
Tremor 443.66 10.01 1304 273316 200928 110113751
Dysphoria 440.16 10.01 245 274375 6183 110308496
Duodenal ulcer perforation 414.22 10.01 5 274615 177695 110136984
Glossodynia 406.83 10.01 40 274580 221964 110092715
Hand deformity 404.03 10.01 38 274582 218468 110096211
Pericarditis 400.17 10.01 40 274580 219074 110095605
Irritability 392.49 10.01 537 274083 47272 110267407
Anxiety 386.34 10.01 1789 272831 343289 109971390
Somnolence 362.85 10.01 1582 273038 295867 110018812
Feeling abnormal 356.70 10.01 1123 273497 179588 110135091
Agitation 348.85 10.01 828 273792 112223 110202456
Folliculitis 348.47 10.01 16 274604 167637 110147042
Febrile neutropenia 347.77 10.01 176 274444 316591 109998088
Suicide attempt 345.09 10.01 781 273839 102613 110212066
Fall 341.19 10.01 2614 272006 600868 109713811
Toxicity to various agents 334.20 10.01 2189 272431 478366 109836313
Withdrawal syndrome 308.14 10.01 385 274235 30995 110283684
Stubbornness 299.12 10.01 88 274532 353 110314326
Synovitis 295.32 10.01 156 274464 273936 110040743
Anti-cyclic citrullinated peptide antibody positive 294.35 10.01 49 274571 181935 110132744
C-reactive protein abnormal 292.35 10.01 6 274614 129689 110184990
Systemic lupus erythematosus 288.73 10.01 135 274485 254203 110060476
Muscle injury 287.63 10.01 15 274605 140792 110173887
Rheumatic fever 283.23 10.01 4 274616 122575 110192104
Helicobacter infection 279.03 10.01 56 274564 181821 110132858
Wound 268.34 10.01 123 274497 234314 110080365
Nausea 255.77 10.01 4395 270225 1231295 109083384
Headache 238.17 10.01 3284 271336 879093 109435586
Drug interaction 236.81 10.01 2082 272538 498101 109816578
Dizziness 236.38 10.01 2711 271909 695482 109619197
Coordination abnormal 227.94 10.01 297 274323 24931 110289748
Depression 226.71 10.01 1456 273164 315879 109998800
Vertigo 226.69 10.01 597 274023 86273 110228406
Sleep disorder due to general medical condition, insomnia type 226.53 10.01 8 274612 105635 110209044
Mood swings 225.76 10.01 281 274339 22531 110292148
Infusion related reaction 220.31 10.01 380 274240 380782 109933897
Impaired healing 219.28 10.01 107 274513 196610 110118069
Affective disorder 217.88 10.01 198 274422 11043 110303636
General physical health deterioration 217.79 10.01 456 274164 424839 109889840
Lip dry 213.15 10.01 8 274612 100075 110214604
Sensory disturbance 209.33 10.01 237 274383 17192 110297487
Facet joint syndrome 208.79 10.01 7 274613 96821 110217858
Personality disorder 206.60 10.01 204 274416 12633 110302046
Pyrexia 206.13 10.01 1346 273274 896919 109417760
Contraindicated product administered 204.38 10.01 189 274431 248078 110066601
Mood altered 203.10 10.01 258 274362 21117 110293562
Thrombocytopenia 197.81 10.01 352 274268 348533 109966146
Disturbance in attention 192.19 10.01 455 274165 61540 110253139
Swollen joint count increased 192.11 10.01 3 274617 83658 110231021
Rheumatoid factor positive 190.83 10.01 46 274574 131594 110183085
Myelosuppression 189.72 10.01 11 274609 94329 110220350
Blister 188.46 10.01 172 274448 227204 110087475
Intentional self-injury 187.56 10.01 335 274285 37094 110277585
Insomnia 182.06 10.01 1523 273097 359067 109955612
Irritable bowel syndrome 181.99 10.01 90 274530 164125 110150554
Stomatitis 180.55 10.01 244 274376 269998 110044681
Sedation 179.88 10.01 477 274143 69206 110245473
Anaemia 178.98 10.01 725 273895 546361 109768318
Intentional overdose 176.29 10.01 724 273896 131777 110182902
Thinking abnormal 175.28 10.01 202 274418 14938 110299741
Inappropriate antidiuretic hormone secretion 173.52 10.01 306 274314 33545 110281134
Depressed mood 173.23 10.01 432 274188 60377 110254302
Pancytopenia 173.20 10.01 159 274461 209454 110105225
Swelling 172.52 10.01 385 274235 350656 109964023
Neutropenia 158.30 10.01 444 274176 374176 109940503
Lower respiratory tract infection 155.90 10.01 226 274394 242880 110071799
Crying 154.39 10.01 249 274371 25379 110289300
Arthropathy 153.31 10.01 301 274319 287221 110027458
Ill-defined disorder 150.99 10.01 102 274518 156751 110157928
Loss of consciousness 150.24 10.01 917 273703 195389 110119290
Anger 147.75 10.01 208 274412 18799 110295880
Peripheral venous disease 146.82 10.01 18 274602 84099 110230580
Alopecia 146.32 10.01 443 274177 364310 109950369
Joint swelling 145.31 10.01 586 274034 442259 109872420
Neurologic neglect syndrome 144.54 10.01 145 274475 9153 110305526
Pulmonary fibrosis 143.38 10.01 38 274582 102004 110212675
Abnormal behaviour 142.76 10.01 306 274314 38733 110275946
Carotid artery thrombosis 141.98 10.01 146 274474 9492 110305187
Maternal exposure during pregnancy 140.98 10.01 261 274359 254622 110060057
Influenza like illness 140.39 10.01 511 274109 87901 110226778
Electric shock 137.10 10.01 74 274546 1754 110312925
Multiple sclerosis 136.52 10.01 236 274384 25462 110289217
Discomfort 135.31 10.01 202 274418 214505 110100174
Adjustment disorder 131.70 10.01 148 274472 10647 110304032
Live birth 131.31 10.01 11 274609 69473 110245206
Tardive dyskinesia 129.16 10.01 164 274456 13415 110301264
Treatment failure 127.41 10.01 315 274305 276919 110037760
Product substitution issue 126.74 10.01 215 274405 22846 110291833
Balance disorder 125.54 10.01 598 274022 115962 110198717
Multiple sclerosis relapse 124.71 10.01 339 274281 49901 110264778
Mental disorder 123.81 10.01 288 274332 38503 110276176
Fatigue 123.32 10.01 3917 270703 1212041 109102638
Liver injury 123.16 10.01 115 274505 150298 110164381
Joint range of motion decreased 123.03 10.01 75 274545 121757 110192922
Skin haemorrhage 122.84 10.01 221 274399 24606 110290073
Blood pressure increased 122.80 10.01 1077 273543 257296 110057383
Lung disorder 119.78 10.01 163 274457 179884 110134795
Type 2 diabetes mellitus 119.37 10.01 159 274461 177073 110137606
Wound infection 119.37 10.01 45 274575 96420 110218259
Somatic symptom disorder 118.30 10.01 82 274538 3077 110311602
Abdominal discomfort 115.86 10.01 543 274077 393315 109921364
Acute kidney injury 114.34 10.01 1018 273602 634412 109680267
Injury 112.44 10.01 166 274454 177099 110137580
Coma 111.57 10.01 583 274037 117286 110197393
Confusional state 109.26 10.01 1702 272918 466978 109847701
Sinus disorder 108.89 10.01 247 274373 32481 110282198
Sopor 108.71 10.01 264 274356 36282 110278397
Multiple organ dysfunction syndrome 107.46 10.01 131 274489 151579 110163100
Rash 106.93 10.01 1417 273203 819547 109495132
Post-traumatic stress disorder 106.48 10.01 105 274515 6491 110308188
Blood cholesterol increased 105.04 10.01 186 274434 184599 110130080
Urinary retention 104.98 10.01 396 274224 69287 110245392
Sinus congestion 103.71 10.01 232 274388 30227 110284452
Pain 101.59 10.01 3095 271525 951860 109362819
Tinnitus 101.31 10.01 356 274264 60184 110254495
Overdose 101.13 10.01 955 273665 232839 110081840
Infection 100.93 10.01 509 274111 361691 109952988
Restless legs syndrome 100.56 10.01 202 274418 24424 110290255
Reversible cerebral vasoconstriction syndrome 100.48 10.01 88 274532 4673 110310006
Dissociation 100.22 10.01 123 274497 9719 110304960
Malignant neoplasm progression 99.87 10.01 175 274445 174392 110140287
Panic attack 99.17 10.01 221 274399 28719 110285960
Product dose omission issue 99.07 10.01 1228 273392 320554 109994125
Disorientation 98.61 10.01 392 274228 70279 110244400
Disease progression 96.65 10.01 298 274322 243736 110070943
Cystitis 95.96 10.01 371 274249 65665 110249014
Bursitis 95.42 10.01 109 274511 129809 110184870
Blepharospasm 95.09 10.01 12 274608 54839 110259840
Sensory loss 94.88 10.01 182 274438 21275 110293404
Septic shock 93.72 10.01 154 274466 157374 110157305
Hallucination, visual 93.11 10.01 262 274358 39343 110275336
Eating disorder 92.95 10.01 224 274396 30634 110284045
Onychomadesis 92.81 10.01 5 274615 45658 110269021
Respiratory tract congestion 91.88 10.01 223 274397 30634 110284045
Inflammation 91.57 10.01 216 274404 193022 110121657
Hallucination 90.74 10.01 494 274126 100938 110213741
Mobility decreased 90.47 10.01 295 274325 237127 110077552
Wheezing 89.25 10.01 329 274291 254901 110059778
Arterial occlusive disease 88.50 10.01 146 274474 15162 110299517
Ascites 88.43 10.01 61 274559 92747 110221932
Cardiac failure 87.10 10.01 212 274408 187414 110127265
Hyperreflexia 86.20 10.01 112 274508 9373 110305306
Mania 85.41 10.01 171 274449 20625 110294054
Therapeutic product effect decreased 84.73 10.01 316 274304 244000 110070679
Platelet count decreased 84.60 10.01 291 274329 230152 110084527
Oedema 84.15 10.01 255 274365 209721 110104958
Paraesthesia 83.69 10.01 1052 273568 275469 110039210
Hypercholesterolaemia 82.26 10.01 63 274557 90774 110223905
Motor dysfunction 82.09 10.01 185 274435 24221 110290458
Intentional product use issue 81.89 10.01 327 274293 247579 110067100
Sepsis 81.81 10.01 477 274143 326869 109987810
Pneumonia aspiration 81.19 10.01 408 274212 80825 110233854
Hallucination, auditory 81.00 10.01 193 274427 26204 110288475
Cytomegalovirus infection 80.93 10.01 18 274602 54426 110260253
Obesity 80.14 10.01 98 274522 113253 110201426
Liver disorder 80.09 10.01 144 274476 142099 110172580
Grip strength decreased 80.05 10.01 50 274570 80124 110234555
C-reactive protein increased 79.45 10.01 276 274344 217643 110097036
Psoriasis 79.08 10.01 607 274013 139386 110175293
Gangrene 78.98 10.01 144 274476 16197 110298482
Vision blurred 78.88 10.01 570 274050 128452 110186227
Autoimmune disorder 78.62 10.01 32 274588 65451 110249228
Lethargy 78.55 10.01 448 274172 93128 110221551
Aphasia 78.14 10.01 322 274298 58675 110256004
Muscle spasticity 78.06 10.01 231 274389 35684 110278995
Adjustment disorder with depressed mood 77.55 10.01 9 274611 43874 110270805
Drug abuse 77.35 10.01 726 273894 176685 110137994
Nasal turbinate hypertrophy 77.12 10.01 39 274581 805 110313874
Nail disorder 76.91 10.01 24 274596 57911 110256768
Colitis microscopic 76.43 10.01 127 274493 13267 110301412
Sciatica 76.39 10.01 70 274550 92329 110222350
Suspected suicide 76.09 10.01 136 274484 15063 110299616
Nephrolithiasis 75.91 10.01 346 274274 65866 110248813
Dyskinesia 75.54 10.01 290 274330 51156 110263523
Abnormal dreams 75.38 10.01 123 274497 12657 110302022
Hypomania 75.33 10.01 109 274511 10101 110304578
Delusion of grandeur 73.88 10.01 54 274566 2206 110312473
Hot flush 73.43 10.01 342 274278 65694 110248985
Hyperaesthesia 72.74 10.01 131 274489 14596 110300083
Opsoclonus myoclonus 71.57 10.01 27 274593 263 110314416
Dysarthria 71.44 10.01 404 274216 83717 110230962
Hypersensitivity 70.92 10.01 651 273969 403347 109911332
Dysphagia 70.72 10.01 636 273984 152964 110161715
Hemiplegia 70.37 10.01 167 274453 22615 110292064
Oesophageal spasm 69.92 10.01 64 274556 3602 110311077
Bone erosion 69.60 10.01 15 274605 46356 110268323
Oedema peripheral 69.39 10.01 504 274116 328156 109986523
Lymphocyte count abnormal 68.28 10.01 53 274567 2373 110312306
Restlessness 68.26 10.01 299 274321 55960 110258719
Psychotic disorder 68.24 10.01 279 274341 50658 110264021
Palpitations 68.14 10.01 649 273971 158563 110156116
Bronchial neoplasm 67.92 10.01 31 274589 505 110314174
Sleep apnoea syndrome 67.80 10.01 238 274382 40209 110274470
Renal impairment 67.79 10.01 240 274380 188205 110126474
Intervertebral discitis 67.40 10.01 85 274535 6905 110307774
Lymphocytic oesophagitis 67.29 10.01 18 274602 46 110314633
Myoclonus 66.80 10.01 207 274413 32791 110281888
Major depression 66.45 10.01 105 274515 10516 110304163
Clonus 65.70 10.01 94 274526 8622 110306057
Libido increased 64.02 10.01 52 274568 2487 110312192
Peripheral swelling 62.98 10.01 670 273950 403364 109911315
Coma blister 62.38 10.01 23 274597 209 110314470
Gastric bypass 61.85 10.01 41 274579 1428 110313251
Lupus-like syndrome 61.62 10.01 13 274607 40779 110273900
Neck deformity 61.51 10.01 45 274575 1841 110312838
Pleural effusion 61.50 10.01 230 274390 177479 110137200
Blood creatinine increased 61.17 10.01 240 274380 182649 110132030
Pulmonary malformation 61.16 10.01 23 274597 222 110314457
Cytokine release syndrome 60.85 10.01 51 274569 70255 110244424
Coeliac disease 60.82 10.01 16 274604 43171 110271508
Memory impairment 60.74 10.01 752 273868 196192 110118487
Muscle twitching 58.95 10.01 186 274434 29749 110284930
Renal failure 58.83 10.01 326 274294 226248 110088431
Bradyphrenia 58.79 10.01 105 274515 11623 110303056
Influenza 57.56 10.01 658 273962 168443 110146236
Extrapyramidal disorder 57.43 10.01 180 274440 28687 110285992
Swollen tongue 57.40 10.01 299 274321 60063 110254616
Alanine aminotransferase increased 57.22 10.01 703 273917 183070 110131609
Head injury 57.13 10.01 235 274385 42782 110271897
Off label use 56.97 10.01 3097 271523 1497088 108817591
Joint noise 56.83 10.01 67 274553 5076 110309603
Onychomycosis 56.75 10.01 13 274607 38518 110276161
Endometrial ablation 56.49 10.01 33 274587 915 110313764
Neutrophil count decreased 55.85 10.01 137 274483 120804 110193875
Bezoar 55.40 10.01 59 274561 3995 110310684
Hostility 55.23 10.01 49 274571 2647 110312032
Sneezing 55.17 10.01 190 274430 31794 110282885
Extremity contracture 55.14 10.01 41 274579 1720 110312959
Paranoia 54.55 10.01 150 274470 22224 110292455
Surgery 54.41 10.01 225 274395 41058 110273621
Drug intolerance 54.11 10.01 698 273922 405814 109908865
Temperature intolerance 54.08 10.01 112 274508 13838 110300841
Bone marrow failure 53.82 10.01 39 274581 57809 110256870
Rubber sensitivity 53.67 10.01 46 274574 2372 110312307
Hypocalcaemia 53.47 10.01 50 274570 65316 110249363
Gastrointestinal tube insertion 52.92 10.01 43 274577 2058 110312621
Drug reaction with eosinophilia and systemic symptoms 52.90 10.01 76 274544 82019 110232660
Breast cancer stage II 52.66 10.01 4 274616 27371 110287308
Concussion 52.41 10.01 99 274521 11439 110303240
Hypersomnia 52.21 10.01 171 274449 27890 110286789
Erythema 51.83 10.01 468 274152 290979 110023700
Post cholecystectomy syndrome 51.67 10.01 30 274590 822 110313857
Drug ineffective for unapproved indication 51.59 10.01 434 274186 102404 110212275
Migraine 51.45 10.01 652 273968 171000 110143679
Aggression 50.69 10.01 285 274335 58925 110255754
Intentional product misuse 50.69 10.01 529 274091 132375 110182304
Rash maculo-papular 50.56 10.01 66 274554 74156 110240523
Psychomotor hyperactivity 50.49 10.01 137 274483 20140 110294539
Pneumonia 50.48 10.01 1727 272893 874987 109439692
Cognitive disorder 50.28 10.01 381 274239 87130 110227549
Taste disorder 50.06 10.01 53 274567 65334 110249345
Ankle fracture 49.45 10.01 134 274486 19685 110294994
Akathisia 49.17 10.01 122 274498 16991 110297688
Finger deformity 49.06 10.01 11 274609 33081 110281598
Tubulointerstitial nephritis 48.70 10.01 38 274582 54246 110260433
Speech disorder 48.57 10.01 290 274330 61279 110253400
Hemiparesis 48.53 10.01 227 274393 43676 110271003
Bone density abnormal 48.45 10.01 54 274566 3849 110310830
Bronchopulmonary aspergillosis 48.35 10.01 8 274612 29855 110284824
Urinary tract infection 47.94 10.01 1104 273516 325178 109989501
Self esteem decreased 47.63 10.01 31 274589 1046 110313633
Apathy 46.90 10.01 116 274504 16123 110298556
Liver function test increased 46.89 10.01 93 274527 88455 110226224
Red blood cell sedimentation rate abnormal 45.98 10.01 4 274616 24505 110290174
Aspergillus infection 45.90 10.01 5 274615 25611 110289068
Haemoglobin decreased 45.71 10.01 396 274224 248331 110066348
Gait disturbance 45.52 10.01 956 273664 277252 110037427
Cataplexy 45.32 10.01 31 274589 1138 110313541
Rebound nasal congestion 44.82 10.01 13 274607 49 110314630
Stiff person syndrome 44.76 10.01 25 274595 635 110314044
Swelling face 44.41 10.01 386 274234 91935 110222744
Poor quality sleep 44.32 10.01 162 274458 27915 110286764
Pregnancy 44.25 10.01 37 274583 51030 110263649
Product administration interrupted 44.17 10.01 91 274529 11201 110303478
Agranulocytosis 44.07 10.01 53 274567 61707 110252972
Decompression sickness 43.60 10.01 15 274605 109 110314570
Toxic epidermal necrolysis 43.40 10.01 46 274574 56681 110257998
Sensitivity to weather change 43.04 10.01 84 274536 9944 110304735
Dyspnoea 42.84 10.01 2280 272340 1104592 109210087
Hyponatraemia 42.75 10.01 769 273851 216884 110097795
Lower limb fracture 42.66 10.01 76 274544 75272 110239407
Autonomic dysreflexia 42.53 10.01 22 274598 477 110314202
Analgesic drug level above therapeutic 42.11 10.01 22 274598 487 110314192
Lung cyst 42.03 10.01 22 274598 489 110314190
Morbid thoughts 41.99 10.01 27 274593 892 110313787
Premature delivery 41.91 10.01 12 274608 30620 110284059
Bipolar disorder 41.81 10.01 78 274542 8929 110305750
Demyelination 41.71 10.01 80 274540 9349 110305330
Neuropathy peripheral 41.65 10.01 651 273969 178626 110136053
Hepatic enzyme increased 41.58 10.01 554 274066 320338 109994341
Rhinalgia 41.46 10.01 50 274570 3879 110310800
Ankylosing spondylitis 41.43 10.01 108 274512 15504 110299175
Blood immunoglobulin A increased 41.42 10.01 33 274587 1535 110313144
Skin exfoliation 41.39 10.01 365 274255 87286 110227393
Impaired driving ability 41.28 10.01 64 274556 6306 110308373
Rapid eye movements sleep abnormal 41.26 10.01 18 274602 262 110314417
Mucosal inflammation 41.25 10.01 113 274507 96028 110218651
Poisoning 41.04 10.01 162 274458 28943 110285736
Back pain 41.02 10.01 1209 273411 369787 109944892
Night sweats 40.96 10.01 182 274438 133801 110180878
Adverse event 40.87 10.01 136 274484 108673 110206006
Neck mass 40.84 10.01 55 274565 4766 110309913
Bruxism 40.83 10.01 56 274564 4938 110309741
Product use issue 40.79 10.01 537 274083 311158 110003521
Abortion spontaneous 40.68 10.01 181 274439 34101 110280578
Neurodegenerative disorder 40.68 10.01 25 274595 762 110313917
Bronchial haemorrhage 40.56 10.01 31 274589 1356 110313323
Libido decreased 40.39 10.01 61 274559 5874 110308805
Haemoptysis 40.37 10.01 72 274548 71282 110243397
Neutropenic sepsis 40.34 10.01 13 274607 30733 110283946
Loss of control of legs 40.24 10.01 37 274583 2095 110312584
Post-traumatic neck syndrome 39.48 10.01 40 274580 2555 110312124
Galactorrhoea 39.23 10.01 50 274570 4105 110310574
Exposure during pregnancy 39.16 10.01 249 274371 167175 110147504
Frequent bowel movements 38.65 10.01 74 274546 71316 110243363
Colitis ulcerative 38.64 10.01 84 274536 77279 110237400
Seizure 38.46 10.01 767 273853 220418 110094261
Snoring 38.27 10.01 64 274556 6720 110307959
Haematotoxicity 38.07 10.01 4 274616 21078 110293601
Anovulatory cycle 37.89 10.01 14 274606 128 110314551
Chronic idiopathic pain syndrome 37.76 10.01 16 274604 216 110314463
Mydriasis 37.67 10.01 131 274489 22026 110292653
Respiratory arrest 37.62 10.01 261 274359 58038 110256641
Dystonia 37.50 10.01 145 274475 25660 110289019
Nervousness 37.46 10.01 186 274434 36665 110278014
Middle insomnia 37.31 10.01 124 274496 20378 110294301
Thrombotic microangiopathy 37.07 10.01 13 274607 29136 110285543
Aspartate aminotransferase increased 36.86 10.01 580 274040 159356 110155323
Drug-induced liver injury 36.76 10.01 163 274457 119904 110194775
Urinary incontinence 36.51 10.01 226 274394 48361 110266318
Aplastic anaemia 36.20 10.01 8 274612 24300 110290379
Sexual dysfunction 36.06 10.01 71 274549 8459 110306220
Respiratory failure 35.61 10.01 352 274268 214980 110099699
Vitamin B12 increased 35.59 10.01 34 274586 2021 110312658
Drug resistance 35.53 10.01 53 274567 56321 110258358
White blood cell count decreased 35.46 10.01 381 274239 229009 110085670
Tumour lysis syndrome 35.46 10.01 16 274604 30785 110283894
Porphyria acute 35.41 10.01 3 274617 18777 110295902
Osteoarthritis 35.24 10.01 287 274333 182336 110132343
Dementia 35.18 10.01 164 274456 31509 110283170
Acute myeloid leukaemia 35.05 10.01 26 274594 38084 110276595
Intervertebral disc protrusion 34.97 10.01 149 274471 27549 110287130
Neuralgia 34.88 10.01 223 274397 48255 110266424
Product tampering 34.84 10.01 19 274601 460 110314219
Sleep-related eating disorder 34.61 10.01 24 274596 901 110313778
Respiratory depression 34.30 10.01 164 274456 31837 110282842
Enterococcal infection 34.01 10.01 5 274615 20361 110294318
Antidepressant drug level above therapeutic 34.00 10.01 22 274598 735 110313944
Undifferentiated connective tissue disease 33.86 10.01 15 274605 227 110314452
Drug tolerance decreased 33.81 10.01 13 274607 27527 110287152
Hip arthroplasty 33.71 10.01 54 274566 55759 110258920
Psychotic disorder due to a general medical condition 33.52 10.01 16 274604 290 110314389
Rheumatoid factor increased 33.43 10.01 36 274584 2469 110312210
Spinal operation 33.42 10.01 80 274540 10892 110303787
Gait inability 33.36 10.01 200 274420 136176 110178503
Disseminated intravascular coagulation 33.27 10.01 32 274588 41254 110273425
Hypomagnesaemia 33.19 10.01 62 274558 60308 110254371
Respiratory tract malformation 33.14 10.01 12 274608 103 110314576
Throat irritation 32.95 10.01 237 274383 53315 110261364
Palmar-plantar erythrodysaesthesia syndrome 32.83 10.01 32 274588 40993 110273686
Formication 32.83 10.01 54 274566 5594 110309085
Dysphonia 32.71 10.01 310 274310 75619 110239060
Oesophageal pain 32.52 10.01 51 274569 5074 110309605
Alcoholism 32.49 10.01 43 274577 3664 110311015
Coronary artery disease 32.47 10.01 82 274538 71608 110243071
Leukopenia 32.43 10.01 226 274394 148565 110166114
Musculoskeletal discomfort 32.38 10.01 130 274490 23408 110291271
Dissociative disorder 32.35 10.01 26 274594 1225 110313454
Sacroiliitis 32.24 10.01 50 274570 4928 110309751
Phagophobia 31.89 10.01 10 274610 52 110314627
Genital pain 31.82 10.01 27 274593 1373 110313306
Reversible airways obstruction 31.75 10.01 35 274585 2464 110312215
Hyperkalaemia 31.73 10.01 202 274418 135594 110179085
Rheumatoid nodule 31.63 10.01 6 274614 20290 110294389
Rhinorrhoea 31.62 10.01 392 274228 102274 110212405
Glomerular filtration rate increased 31.47 10.01 31 274589 1914 110312765
Emotional disorder 31.44 10.01 100 274520 16060 110298619
Product used for unknown indication 31.22 10.01 31 274589 1932 110312747
Pneumocystis jirovecii pneumonia 31.21 10.01 36 274584 42699 110271980
Complex regional pain syndrome 31.11 10.01 34 274586 2371 110312308
Poor sucking reflex 31.10 10.01 12 274608 125 110314554
Haemophagocytic lymphohistiocytosis 31.06 10.01 20 274600 31539 110283140
Lactation disorder 30.97 10.01 15 274605 281 110314398
Pre-existing condition improved 30.90 10.01 57 274563 6469 110308210
Soft tissue injury 30.88 10.01 33 274587 2243 110312436
Toxic skin eruption 30.59 10.01 15 274605 27500 110287179
Neuroleptic malignant syndrome 30.53 10.01 166 274454 33893 110280786
Drug screen positive 30.36 10.01 56 274564 6354 110308325
Psoriatic arthropathy 30.33 10.01 327 274293 196434 110118245
Rectal haemorrhage 30.23 10.01 174 274446 119659 110195020
Interstitial lung disease 30.18 10.01 212 274408 139122 110175557
Homicidal ideation 30.15 10.01 41 274579 3586 110311093
Hypnopompic hallucination 30.12 10.01 11 274609 97 110314582
Urticaria 30.10 10.01 584 274036 318273 109996406
Spinal disorder 29.97 10.01 80 274540 11648 110303031
Pseudomonas infection 29.75 10.01 16 274604 27837 110286842
Laryngitis 29.62 10.01 37 274583 42374 110272305
Feeling jittery 29.47 10.01 92 274528 14630 110300049
Increased appetite 29.43 10.01 93 274527 14884 110299795
Prostate cancer 29.39 10.01 30 274590 37611 110277068
Red blood cell sedimentation rate increased 29.31 10.01 98 274522 78204 110236475
Rib fracture 29.20 10.01 163 274457 33607 110281072
Gastrointestinal disorder 29.09 10.01 424 274196 241528 110073151
Movement disorder 29.05 10.01 172 274448 36232 110278447
Burning sensation 29.04 10.01 281 274339 68931 110245748
Metabolic surgery 28.99 10.01 26 274594 1425 110313254
Thunderclap headache 28.96 10.01 18 274602 560 110314119
Epilepsy 28.92 10.01 139 274481 100070 110214609
Feeling of despair 28.68 10.01 41 274579 3757 110310922
Proctitis 28.63 10.01 4 274616 16923 110297756
Bronchiectasis 28.59 10.01 29 274591 36464 110278215
Bacteraemia 28.56 10.01 38 274582 42352 110272327
Depressive symptom 28.54 10.01 64 274556 8350 110306329
Sternal fracture 28.35 10.01 38 274582 3278 110311401
Arteriosclerosis coronary artery 27.85 10.01 130 274490 24988 110289691
Therapy non-responder 27.77 10.01 253 274367 157054 110157625
Blood lactate dehydrogenase increased 27.63 10.01 42 274578 44292 110270387
Substance dependence 27.57 10.01 19 274601 706 110313973
White blood cells urine positive 27.53 10.01 59 274561 7465 110307214
Normal newborn 27.44 10.01 10 274610 21886 110292793
Feeling guilty 27.35 10.01 21 274599 925 110313754
Granulocyte count increased 27.35 10.01 29 274591 1954 110312725
Venoocclusive liver disease 27.17 10.01 3 274617 15204 110299475
Delusion 27.12 10.01 124 274496 23631 110291048
Aspartate aminotransferase 26.90 10.01 21 274599 948 110313731
Growth hormone deficiency 26.84 10.01 16 274604 461 110314218
Condition aggravated 26.80 10.01 1522 273098 733314 109581365
Second primary malignancy 26.80 10.01 6 274614 18062 110296617
Musculoskeletal pain 26.69 10.01 308 274312 182715 110131964
Gambling disorder 26.66 10.01 30 274590 2161 110312518
Lactic acidosis 26.63 10.01 129 274491 92682 110221997
Foot deformity 26.46 10.01 50 274570 48430 110266249
Dysstasia 26.42 10.01 156 274464 32830 110281849
Hypophosphataemia 26.41 10.01 26 274594 33156 110281523
Illness 26.28 10.01 316 274304 81855 110232824
Epstein-Barr virus infection 26.27 10.01 7 274613 18731 110295948
Burning mouth syndrome 26.26 10.01 18 274602 663 110314016
Drug eruption 26.19 10.01 59 274561 53600 110261079
Cytomegalovirus viraemia 26.15 10.01 6 274614 17758 110296921
Pain in extremity 26.13 10.01 1469 273151 485649 109829030
Antidepressant discontinuation syndrome 26.13 10.01 11 274609 146 110314533
Product quality issue 26.11 10.01 101 274519 77198 110237481
Dactylitis 26.05 10.01 41 274579 4092 110310587
Electric shock sensation 26.05 10.01 28 274592 1916 110312763
Carcinoid tumour pulmonary 25.90 10.01 15 274605 409 110314270
Back injury 25.77 10.01 49 274571 47350 110267329
Product prescribing error 25.40 10.01 216 274404 51115 110263564
Vasculitis 25.37 10.01 31 274589 35842 110278837
Atrial fibrillation 25.36 10.01 409 274211 229233 110085446
Blood calcium decreased 25.32 10.01 31 274589 35814 110278865
Skin necrosis 25.04 10.01 11 274609 21501 110293178
Anaphylactic shock 24.90 10.01 57 274563 51489 110263190
Therapeutic response changed 24.72 10.01 25 274595 1593 110313086
Speech sound disorder 24.70 10.01 8 274612 47 110314632
Initial insomnia 24.68 10.01 69 274551 10320 110304359
Decreased interest 24.68 10.01 44 274576 4864 110309815
Rhonchi 24.66 10.01 42 274578 4476 110310203
Corneal reflex decreased 24.66 10.01 16 274604 537 110314142
Amimia 24.58 10.01 9 274611 80 110314599
Cerebral infarction 24.50 10.01 58 274562 51780 110262899
Anorgasmia 24.36 10.01 25 274595 1621 110313058
Somnambulism 24.33 10.01 51 274569 6354 110308325
Depressed level of consciousness 24.30 10.01 403 274217 111875 110202804
Hypokinesia 24.23 10.01 113 274507 21713 110292966
Death 24.14 10.01 1455 273165 697414 109617265
Creatinine renal clearance decreased 24.09 10.01 12 274608 21803 110292876
Bronchial disorder 24.02 10.01 32 274588 2744 110311935
Gastrointestinal haemorrhage 23.96 10.01 279 274341 165239 110149440
Adverse reaction 23.78 10.01 23 274597 29571 110285108
Hypoventilation 23.63 10.01 58 274562 8023 110306656
Tension 23.60 10.01 44 274576 5034 110309645
Female genital tract fistula 23.49 10.01 6 274614 16513 110298166
End stage renal disease 23.43 10.01 12 274608 21461 110293218
Intervertebral disc degeneration 23.39 10.01 98 274522 17987 110296692
Central pain syndrome 23.26 10.01 18 274602 802 110313877
Muscular weakness 23.06 10.01 793 273827 247675 110067004
Postictal psychosis 23.00 10.01 12 274608 265 110314414
Syncope 22.90 10.01 662 273958 201874 110112805
Hepatic steatosis 22.87 10.01 203 274417 48628 110266051
Acute pulmonary oedema 22.63 10.01 7 274613 16989 110297690
Maternal exposure during breast feeding 22.61 10.01 39 274581 4199 110310480
Food aversion 22.46 10.01 24 274596 1631 110313048
Cardiac murmur 22.40 10.01 17 274603 24611 110290068
Metastases to bone 22.30 10.01 27 274593 31345 110283334
Infusion site reaction 22.29 10.01 8 274612 17674 110297005
Hyperbilirubinaemia 22.22 10.01 26 274594 30645 110284034
Pulmonary eosinophilia 22.18 10.01 17 274603 747 110313932
Hypertonia 22.15 10.01 58 274562 8348 110306331
False positive radioisotope investigation result 21.98 10.01 6 274614 17 110314662
Hepatotoxicity 21.96 10.01 82 274538 63318 110251361
Weight increased 21.82 10.01 1262 273358 418382 109896297
Exposure via breast milk 21.69 10.01 19 274601 1009 110313670
Pneumonia fungal 21.68 10.01 5 274615 14749 110299930
Haematochezia 21.63 10.01 183 274437 115341 110199338
Epistaxis 21.59 10.01 213 274407 130159 110184520
Hyponatraemic encephalopathy 21.49 10.01 13 274607 385 110314294
Mental impairment 21.42 10.01 112 274508 22527 110292152
Hysterectomy 21.39 10.01 56 274564 8058 110306621
Progressive multifocal leukoencephalopathy 21.28 10.01 120 274500 24836 110289843
Anal incontinence 21.02 10.01 109 274511 21855 110292824
Cleft palate 20.96 10.01 13 274607 403 110314276
Hyperventilation 20.84 10.01 59 274561 8888 110305791
Autonomic nervous system imbalance 20.78 10.01 45 274575 5735 110308944
Antidepressant drug level increased 20.78 10.01 15 274605 601 110314078
Foetal death 20.67 10.01 7 274613 16038 110298641
Klebsiella infection 20.64 10.01 12 274608 19997 110294682
Pathogen resistance 20.63 10.01 9 274611 17663 110297016
Amnesia 20.53 10.01 372 274248 105036 110209643
Hypoalbuminaemia 20.53 10.01 25 274595 28949 110285730
Hepatitis E antibody positive 20.48 10.01 11 274609 258 110314421
Metastases to central nervous system 20.43 10.01 16 274604 22801 110291878
Compulsive shopping 20.26 10.01 17 274603 851 110313828
Blood alkaline phosphatase increased 20.21 10.01 267 274353 70668 110244011
Depression suicidal 20.21 10.01 40 274580 4784 110309895
Myelodysplastic syndrome 20.16 10.01 39 274581 37445 110277234
Vitamin B12 decreased 20.14 10.01 42 274578 5215 110309464
Sleep talking 20.12 10.01 20 274600 1248 110313431
Product use in unapproved indication 20.06 10.01 907 273713 446470 109868209
Clitoral engorgement 20.00 10.01 4 274616 0 110314679
Phobia of driving 20.00 10.01 4 274616 0 110314679
Ulcer haemorrhage 19.99 10.01 16 274604 22555 110292124
Panic disorder 19.99 10.01 33 274587 3428 110311251
Feeling drunk 19.98 10.01 43 274577 5457 110309222
Scar 19.93 10.01 89 274531 16792 110297887
Claustrophobia 19.87 10.01 22 274598 1557 110313122
Graft versus host disease 19.80 10.01 11 274609 18795 110295884
Joint dislocation 19.79 10.01 34 274586 34156 110280523
Hypertensive urgency 19.77 10.01 19 274601 1138 110313541
Haematuria 19.63 10.01 123 274497 82882 110231797
Proteinuria 19.53 10.01 44 274576 39974 110274705
Persistent genital arousal disorder 19.53 10.01 15 274605 661 110314018
Tenosynovitis 19.48 10.01 8 274612 16275 110298404
Sciatic nerve injury 19.42 10.01 16 274604 781 110313898
Progressive multiple sclerosis 19.40 10.01 20 274600 1304 110313375
Angina pectoris 19.24 10.01 238 274382 62057 110252622
Ejection fraction decreased 19.11 10.01 46 274574 40834 110273845
Hepatitis E virus test positive 19.09 10.01 11 274609 297 110314382
Bacterial infection 19.08 10.01 55 274565 45981 110268698
Feelings of worthlessness 19.07 10.01 14 274606 576 110314103
Exostosis 18.98 10.01 55 274565 45901 110268778
Melaena 18.90 10.01 97 274523 68660 110246019
Bradycardia 18.87 10.01 272 274348 155245 110159434
Drug screen false positive 18.84 10.01 20 274600 1349 110313330
Pulseless electrical activity 18.83 10.01 9 274611 16748 110297931
Basal cell carcinoma 18.83 10.01 54 274566 45216 110269463
Post concussion syndrome 18.82 10.01 15 274605 698 110313981
Scoliosis 18.81 10.01 56 274564 8677 110306002
Knee arthroplasty 18.79 10.01 90 274530 64858 110249821
Musculoskeletal stiffness 18.75 10.01 540 274080 279282 110035397
Cardiac failure congestive 18.71 10.01 263 274357 150737 110163942
Metastases to lymph nodes 18.61 10.01 7 274613 15025 110299654
Drug dependence 18.55 10.01 198 274422 49822 110264857
Bladder cancer 18.46 10.01 14 274606 20278 110294401
Eye pain 18.43 10.01 198 274422 49901 110264778
Activated partial thromboplastin time prolonged 18.42 10.01 17 274603 22351 110292328
Neoplasm progression 18.40 10.01 90 274530 64505 110250174
Vitamin D deficiency 18.40 10.01 93 274527 18459 110296220
CYP3A4 polymorphism 18.39 10.01 7 274613 70 110314609
Social avoidant behaviour 18.39 10.01 41 274579 5328 110309351
Sinus tachycardia 18.35 10.01 180 274440 44313 110270366
Neutrophil count increased 18.32 10.01 148 274472 34504 110280175
Myofascial pain syndrome 18.30 10.01 27 274593 2546 110312133
Pulmonary alveolar haemorrhage 18.21 10.01 14 274606 20136 110294543
Foetal exposure timing unspecified 18.13 10.01 7 274613 73 110314606
Medical device site thrombosis 18.12 10.01 8 274612 120 110314559
Hyperphosphataemia 18.10 10.01 9 274611 16372 110298307
Metastases to liver 18.02 10.01 38 274582 35348 110279331
Accidental death 18.01 10.01 39 274581 4970 110309709
Total cholesterol/HDL ratio abnormal 17.72 10.01 7 274613 78 110314601
Hepatic cirrhosis 17.70 10.01 97 274523 67529 110247150
Illness anxiety disorder 17.69 10.01 10 274610 260 110314419
Bronchitis 17.67 10.01 513 274107 156519 110158160
Trigger finger 17.57 10.01 39 274581 5053 110309626
Screaming 17.54 10.01 38 274582 4843 110309836
Diplopia 17.53 10.01 170 274450 41724 110272955
Mental status changes 17.51 10.01 276 274344 75846 110238833
Dermatitis atopic 17.46 10.01 116 274504 25425 110289254
Genital ulceration 17.45 10.01 23 274597 1952 110312727
Walking aid user 17.38 10.01 22 274598 25053 110289626
Respiratory distress 17.37 10.01 100 274520 68774 110245905
Reaction to azo-dyes 17.21 10.01 5 274615 19 110314660
Open reduction of fracture 17.16 10.01 10 274610 276 110314403
Acute graft versus host disease in skin 17.12 10.01 3 274617 10737 110303942
Renal tubular necrosis 17.01 10.01 31 274589 30444 110284235
Amenorrhoea 16.95 10.01 56 274564 9175 110305504
Impaired quality of life 16.85 10.01 130 274490 29887 110284792
Atrioventricular block complete 16.85 10.01 15 274605 20067 110294612
Rales 16.84 10.01 22 274598 24717 110289962
Multiple-drug resistance 16.66 10.01 6 274614 13229 110301450
Poverty of speech 16.63 10.01 13 274607 588 110314091
Nasal polyps 16.59 10.01 6 274614 13194 110301485
Urinary hesitation 16.44 10.01 36 274584 4622 110310057
Pulmonary embolism 16.43 10.01 406 274214 214068 110100611
Miosis 16.36 10.01 102 274518 21881 110292798
Pneumonitis 16.30 10.01 117 274503 76414 110238265
Metastases to lung 16.23 10.01 20 274600 23043 110291636
Incontinence 16.23 10.01 83 274537 16552 110298127
Nephrotic syndrome 16.21 10.01 7 274613 13824 110300855
Colitis 16.19 10.01 169 274451 102154 110212525
Nasal congestion 16.14 10.01 338 274282 97944 110216735
Adulterated product 16.12 10.01 17 274603 1138 110313541
Cholestasis 16.10 10.01 94 274526 64424 110250255
Asphyxia 16.08 10.01 74 274546 14141 110300538
Dysuria 16.05 10.01 224 274396 60007 110254672
Bone density decreased 16.02 10.01 10 274610 16032 110298647
Flat affect 16.00 10.01 25 274595 2480 110312199
Uterine disorder 15.96 10.01 24 274596 2302 110312377
Febrile bone marrow aplasia 15.95 10.01 12 274608 17453 110297226
Temperature regulation disorder 15.84 10.01 6 274614 12820 110301859
Device related infection 15.81 10.01 48 274572 39471 110275208
Eosinophilia 15.78 10.01 82 274538 57854 110256825
Impulsive behaviour 15.75 10.01 29 274591 3286 110311393
Cardiogenic shock 15.70 10.01 81 274539 57257 110257422
Convulsive threshold lowered 15.69 10.01 16 274604 1030 110313649
Hypogammaglobulinaemia 15.67 10.01 16 274604 20060 110294619
Fear 15.66 10.01 105 274515 23088 110291591
Shock 15.65 10.01 74 274546 53514 110261165
Feeling of body temperature change 15.60 10.01 42 274578 6146 110308533
Pericardial effusion 15.57 10.01 81 274539 57136 110257543
Pneumothorax 15.49 10.01 41 274579 35244 110279435
SARS-CoV-2 test positive 15.49 10.01 83 274537 16852 110297827
Lacunar stroke 15.43 10.01 12 274608 539 110314140
Apnoea 15.42 10.01 71 274549 13568 110301111
Diabetic retinal oedema 15.41 10.01 11 274609 433 110314246
Pruritus 15.39 10.01 1239 273381 580321 109734358
Intervertebral disc operation 15.36 10.01 16 274604 1056 110313623
Ophthalmic vein thrombosis 15.33 10.01 9 274611 252 110314427
Cycloplegia 15.31 10.01 4 274616 9 110314670
Haemolysis 15.27 10.01 10 274610 15629 110299050
Acute stress disorder 15.12 10.01 12 274608 555 110314124
Impatience 15.12 10.01 14 274606 800 110313879
Alcohol abuse 15.08 10.01 36 274584 4893 110309786
Gastrointestinal injury 15.05 10.01 21 274599 1882 110312797
Emotional distress 15.02 10.01 174 274446 44673 110270006
Eosinophilic granulomatosis with polyangiitis 14.97 10.01 4 274616 10682 110303997
Shoulder operation 14.96 10.01 29 274591 3416 110311263
Breakthrough pain 14.93 10.01 19 274601 1557 110313122
Sinus pain 14.92 10.01 40 274580 5839 110308840
Loose tooth 14.88 10.01 28 274592 3225 110311454
Sluggishness 14.88 10.01 47 274573 7520 110307159
Bipolar I disorder 14.88 10.01 23 274597 2260 110312419
Heart rate increased 14.87 10.01 465 274155 143369 110171310
Granulomatous liver disease 14.86 10.01 19 274601 1565 110313114
Occipital neuralgia 14.83 10.01 13 274607 691 110313988
Myasthenia gravis 14.78 10.01 19 274601 21492 110293187
Poisoning deliberate 14.76 10.01 114 274506 26217 110288462
Throat clearing 14.74 10.01 33 274587 4300 110310379
Blood potassium decreased 14.72 10.01 202 274418 53912 110260767
Tearfulness 14.61 10.01 46 274574 7349 110307330
Pulse abnormal 14.57 10.01 32 274588 4117 110310562
Foot fracture 14.54 10.01 111 274509 25435 110289244
Biliary colic 14.52 10.01 34 274586 4563 110310116
Obsessive-compulsive personality disorder 14.51 10.01 7 274613 130 110314549
Product monitoring error 14.51 10.01 52 274568 8875 110305804
Serum serotonin increased 14.50 10.01 10 274610 372 110314307
Glabellar reflex abnormal 14.45 10.01 5 274615 37 110314642
Escherichia infection 14.42 10.01 23 274597 23793 110290886
Obsessive thoughts 14.40 10.01 17 274603 1290 110313389
Medical device site abscess 14.37 10.01 8 274612 202 110314477
Hypokalaemia 14.35 10.01 344 274276 182104 110132575
Tachyphrenia 14.34 10.01 23 274597 2333 110312346
Ligament injury 14.34 10.01 16 274604 1142 110313537
Toothache 14.31 10.01 104 274516 23471 110291208
Purple glove syndrome 14.25 10.01 9 274611 288 110314391
Drug level decreased 14.23 10.01 15 274605 18533 110296146
Meralgia paraesthetica 14.23 10.01 12 274608 605 110314074
Lymphoedema 14.22 10.01 74 274546 14855 110299824
Gout 14.22 10.01 45 274575 36521 110278158
Oral candidiasis 14.16 10.01 60 274560 44700 110269979
Facial spasm 14.16 10.01 14 274606 868 110313811
Impulse-control disorder 14.16 10.01 22 274598 2172 110312507
Chronic inflammatory demyelinating polyradiculoneuropathy 14.15 10.01 22 274598 2173 110312506
Gastrointestinal toxicity 14.13 10.01 5 274615 11143 110303536
Injection site pain 14.11 10.01 558 274062 177364 110137315
Coagulopathy 14.11 10.01 53 274567 40858 110273821
Cerebrovascular accident 14.02 10.01 567 274053 180717 110133962
Respiratory symptom 14 10.01 10 274610 14935 110299744
Cytopenia 13.99 10.01 34 274586 30082 110284597
Radiation fibrosis 13.90 10.01 5 274615 42 110314637
Food poisoning 13.86 10.01 41 274579 6331 110308348
Vomiting 13.83 10.01 2515 272105 908160 109406519
Polyarthritis 13.82 10.01 16 274604 18947 110295732
Acute myocardial infarction 13.82 10.01 137 274483 83640 110231039
Adiposis dolorosa 13.79 10.01 9 274611 305 110314374
Antinuclear antibody negative 13.78 10.01 7 274613 146 110314533
Skin toxicity 13.75 10.01 6 274614 11777 110302902
Hypnagogic hallucination 13.72 10.01 8 274612 221 110314458
Medical device site cellulitis 13.66 10.01 8 274612 223 110314456
Tongue movement disturbance 13.62 10.01 11 274609 522 110314157
Salpingo-oophorectomy bilateral 13.61 10.01 9 274611 312 110314367
Pyometra 13.59 10.01 6 274614 90 110314589
Cardiomegaly 13.59 10.01 121 274499 29009 110285670
Haemoglobin urine present 13.51 10.01 14 274606 918 110313761
Suicidal behaviour 13.47 10.01 28 274592 3469 110311210
Supraventricular tachyarrhythmia 13.44 10.01 7 274613 154 110314525
Nerve compression 13.36 10.01 59 274561 11078 110303601
Panic reaction 13.29 10.01 36 274584 5286 110309393
Hyperuricaemia 13.25 10.01 10 274610 14521 110300158
Gastric haemorrhage 13.22 10.01 12 274608 15903 110298776
Immobilisation prolonged 13.12 10.01 7 274613 162 110314517
Exposure via ingestion 13.11 10.01 34 274586 4866 110309813
Clostridium difficile colitis 13.06 10.01 60 274560 43718 110270961
Nerve injury 13.04 10.01 57 274563 10656 110304023
Myositis 13.03 10.01 37 274583 31079 110283600
Adverse drug reaction 13.02 10.01 184 274436 105375 110209304
Pupillary reflex impaired 13.02 10.01 30 274590 3985 110310694
Acute respiratory distress syndrome 13.01 10.01 78 274542 53120 110261559
Blood glucose decreased 13.00 10.01 121 274499 29367 110285312
Cardiac failure acute 12.99 10.01 25 274595 24053 110290626
Physical assault 12.93 10.01 18 274602 1610 110313069
Intestinal perforation 12.90 10.01 20 274600 20924 110293755
Application site perspiration 12.89 10.01 4 274616 20 110314659
Gamma-glutamyltransferase increased 12.88 10.01 219 274401 61090 110253589
Haemolytic anaemia 12.86 10.01 20 274600 20900 110293779
Haemodialysis 12.86 10.01 15 274605 17704 110296975
Oropharyngeal pain 12.86 10.01 433 274187 134843 110179836
Illusion 12.78 10.01 20 274600 1987 110312692
Dental restoration failure 12.77 10.01 15 274605 1132 110313547
Enterocolitis 12.75 10.01 17 274603 18932 110295747
Drug ineffective 12.74 10.01 4088 270532 1516452 108798227
Hepatic function abnormal 12.73 10.01 151 274469 89144 110225535
Hypercalcaemia 12.73 10.01 66 274554 46591 110268088
Respiratory tract infection 12.71 10.01 115 274505 71502 110243177
Ventricular hypokinesia 12.64 10.01 6 274614 11208 110303471
Blood bilirubin increased 12.63 10.01 124 274496 75848 110238831
Somatic delusion 12.62 10.01 12 274608 709 110313970
Drug metabolising enzyme decreased 12.57 10.01 4 274616 22 110314657
Communication disorder 12.50 10.01 34 274586 5005 110309674
Hyperglycaemia 12.48 10.01 143 274477 84947 110229732
Trigeminal neuralgia 12.48 10.01 31 274589 4321 110310358
Anaphylactic reaction 12.47 10.01 204 274416 114096 110200583
Gambling 12.41 10.01 9 274611 363 110314316
Mitochondrial encephalomyopathy 12.41 10.01 6 274614 112 110314567
Fibula fracture 12.40 10.01 32 274588 4566 110310113
Inadequate analgesia 12.34 10.01 34 274586 5043 110309636
Angle closure glaucoma 12.30 10.01 27 274593 3472 110311207
Oliguria 12.29 10.01 17 274603 18640 110296039
Dyspnoea exertional 12.27 10.01 183 274437 103877 110210802
Activation syndrome 12.24 10.01 9 274611 371 110314308
Tooth loss 12.18 10.01 46 274574 8050 110306629
Tethered cord syndrome 12.14 10.01 4 274616 25 110314654
Haemorrhage 12.12 10.01 189 274431 106503 110208176
Cushingoid 12.12 10.01 7 274613 11705 110302974
Trismus 12.10 10.01 40 274580 6556 110308123
Acute hepatic failure 12.09 10.01 48 274572 36420 110278259
Frostbite 12.08 10.01 8 274612 278 110314401
Menopausal symptoms 12.04 10.01 22 274598 2479 110312200
Cholecystectomy 12.03 10.01 56 274564 10753 110303926
Paraesthesia oral 12.02 10.01 43 274577 33628 110281051
Iron deficiency 12.00 10.01 17 274603 18459 110296220
Cataract 11.98 10.01 270 274350 79215 110235464
Rapid eye movement sleep behaviour disorder 11.89 10.01 11 274609 628 110314051
Holmes-Adie pupil 11.88 10.01 4 274616 27 110314652
Pulmonary haemorrhage 11.87 10.01 14 274606 16442 110298237
Appendicitis 11.80 10.01 34 274586 28430 110286249
Deep vein thrombosis 11.77 10.01 261 274359 139626 110175053
Gallbladder disorder 11.76 10.01 91 274529 20938 110293741
Prescription form tampering 11.74 10.01 10 274610 511 110314168
Graft versus host disease in skin 11.73 10.01 3 274617 8251 110306428
Lymphoma 11.73 10.01 20 274600 20151 110294528
Cranial nerve decompression 11.72 10.01 3 274617 6 110314673
Psychopathic personality 11.72 10.01 3 274617 6 110314673
Fractured coccyx 11.66 10.01 15 274605 1243 110313436
Benign prostatic hyperplasia 11.63 10.01 17 274603 18217 110296462
Therapeutic response unexpected 11.62 10.01 100 274520 23743 110290936
Mean cell haemoglobin concentration increased 11.62 10.01 14 274606 1085 110313594
Retrograde ejaculation 11.61 10.01 9 274611 402 110314277
Liver function test abnormal 11.61 10.01 238 274382 68712 110245967
Fear-related avoidance of activities 11.60 10.01 6 274614 130 110314549
Conversion disorder 11.60 10.01 21 274599 2349 110312330
Posterior reversible encephalopathy syndrome 11.59 10.01 44 274576 33817 110280862
Overlap syndrome 11.59 10.01 4 274616 9055 110305624
Pseudomonal sepsis 11.56 10.01 4 274616 9042 110305637
Enuresis 11.56 10.01 29 274591 4067 110310612
International normalised ratio increased 11.52 10.01 149 274471 86623 110228056
Instillation site inflammation 11.52 10.01 4 274616 30 110314649
Axillary pain 11.51 10.01 22 274598 2564 110312115
Vasoconstriction 11.51 10.01 14 274606 1096 110313583
Forced expiratory flow decreased 11.50 10.01 8 274612 302 110314377
Self-injurious ideation 11.46 10.01 30 274590 4316 110310363
Nystagmus 11.46 10.01 58 274562 11519 110303160
Alveolar bone resorption 11.45 10.01 5 274615 73 110314606
Blood bilirubin 11.40 10.01 4 274616 31 110314648
Acute painful neuropathy of rapid glycaemic control 11.40 10.01 4 274616 31 110314648
Staphylococcal sepsis 11.40 10.01 16 274604 17438 110297241
Withdrawal hypertension 11.38 10.01 9 274611 414 110314265
Hyperthyroidism 11.38 10.01 36 274584 29225 110285454
Hypoxia 11.38 10.01 240 274380 129275 110185404
Cyst 11.33 10.01 75 274545 16421 110298258
Paralogism 11.29 10.01 4 274616 32 110314647
Biliary dyskinesia 11.28 10.01 21 274599 2400 110312279
Infective pulmonary exacerbation of cystic fibrosis 11.27 10.01 12 274608 14759 110299920
Therapy cessation 11.23 10.01 165 274455 44692 110269987
Tachyphylaxis 11.16 10.01 9 274611 426 110314253
Hallucinations, mixed 11.16 10.01 47 274573 8646 110306033
Abulia 11.15 10.01 15 274605 1298 110313381
Benign vaginal neoplasm 11.15 10.01 5 274615 78 110314601
Chronic sinusitis 11.12 10.01 29 274591 25055 110289624
Vitamin B12 deficiency 11.12 10.01 52 274568 10003 110304676
Bacterial sepsis 11.12 10.01 6 274614 10420 110304259
Large intestine perforation 11.11 10.01 15 274605 16614 110298065
Thirst 11.09 10.01 92 274528 21615 110293064
Limb deformity 11.07 10.01 27 274593 3719 110310960
Cardio-respiratory arrest 11.07 10.01 371 274249 115465 110199214
Wrong patient 11.05 10.01 16 274604 1483 110313196
Excessive eye blinking 11.03 10.01 18 274602 1852 110312827
Cephalo-pelvic disproportion 11.01 10.01 6 274614 145 110314534
Distributive shock 11.00 10.01 36 274584 5868 110308811
Aspartate aminotransferase abnormal 10.95 10.01 25 274595 3300 110311379
Arthritis 10.92 10.01 515 274105 167071 110147608
Tuberculosis 10.92 10.01 17 274603 17757 110296922
Transfusion 10.88 10.01 30 274590 25442 110289237
Rectocele repair 10.87 10.01 3 274617 9 110314670
Angina unstable 10.80 10.01 15 274605 16417 110298262
Dysphemia 10.79 10.01 28 274592 4009 110310670
Intrusive thoughts 10.76 10.01 11 274609 710 110313969
Genital discomfort 10.72 10.01 6 274614 153 110314526
Incorrect dose administered 10.69 10.01 335 274285 103306 110211373
Electrocardiogram QT prolonged 10.67 10.01 350 274270 108610 110206069
Knee operation 10.65 10.01 40 274580 6982 110307697
Narcissistic personality disorder 10.63 10.01 3 274617 10 110314669
Dental caries 10.61 10.01 61 274559 12712 110301967
Embolism 10.57 10.01 15 274605 16274 110298405
Anxiety disorder 10.56 10.01 32 274588 5008 110309671
Food allergy 10.52 10.01 21 274599 19927 110294752
Family stress 10.48 10.01 11 274609 732 110313947
Renal injury 10.48 10.01 19 274601 18694 110295985
Multiple lentigines syndrome 10.43 10.01 7 274613 249 110314430
Vitamin C decreased 10.42 10.01 4 274616 41 110314638
Macular degeneration 10.42 10.01 24 274596 21635 110293044
Aphonia 10.41 10.01 61 274559 12799 110301880
Cholecystitis chronic 10.41 10.01 49 274571 9451 110305228
Labelled drug-drug interaction medication error 10.40 10.01 115 274505 29187 110285492
Delirium tremens 10.39 10.01 11 274609 740 110313939
Economic problem 10.37 10.01 28 274592 4103 110310576
Suspected suicide attempt 10.35 10.01 8 274612 356 110314323
Hypervolaemia 10.35 10.01 76 274544 49384 110265295
Muscle rigidity 10.29 10.01 98 274522 23933 110290746
Blood prolactin increased 10.22 10.01 30 274590 4612 110310067
Iritis 10.18 10.01 30 274590 4622 110310057
Ear infection 10.17 10.01 103 274517 62629 110252050
Spondyloarthropathy 10.16 10.01 16 274604 1598 110313081
Dehydration 10.14 10.01 579 274041 278932 110035747
Magnetic resonance imaging spinal abnormal 10.14 10.01 7 274613 261 110314418
Food craving 10.13 10.01 18 274602 1985 110312694
Binge eating 10.12 10.01 10 274610 620 110314059
Hepatocellular carcinoma 10.09 10.01 6 274614 9874 110304805
Polyneuropathy 10.07 10.01 43 274577 31969 110282710
Dermatitis acneiform 10.04 10.01 10 274610 12685 110301994
Sexual abuse 10.04 10.01 7 274613 265 110314414
Craniocerebral injury 10.01 10.01 35 274585 5899 110308780

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Liver disorder 28.47 27.38 8 564 9 113372
Telangiectasia congenital 27.74 27.38 9 563 22 113359

Pharmacologic Action:

SourceCodeDescription
ATC N06AX21 NERVOUS SYSTEM
PSYCHOANALEPTICS
ANTIDEPRESSANTS
Other antidepressants
FDA MoA N0000000102 Norepinephrine Uptake Inhibitors
FDA MoA N0000000109 Serotonin Uptake Inhibitors
MeSH PA D000068760 Serotonin and Noradrenaline Reuptake Inhibitors
MeSH PA D000700 Analgesics
MeSH PA D000928 Antidepressive Agents
MeSH PA D011619 Psychotropic Drugs
MeSH PA D014179 Neurotransmitter Uptake Inhibitors
MeSH PA D015259 Dopamine Agents
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018689 Sensory System Agents
MeSH PA D049990 Membrane Transport Modulators
FDA EPC N0000175749 Serotonin and Norepinephrine Reuptake Inhibitor
CHEBI has role CHEBI:76779 EC 3.4.21.26 (prolyl oligopeptidase) inhibitor

Related Drugs by ATC class:

N06AX Other antidepressants 28 drugs
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Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Generalized anxiety disorder indication 21897009 DOID:14320
Female stress incontinence indication 60241006 DOID:724
Fibromyalgia indication 203082005 DOID:631
Major depressive disorder indication 370143000
Diabetic peripheral neuropathy indication 424736006
Chronic Musculoskeletal Pain indication
Osteoarthritis off-label use 396275006
Suicidal thoughts contraindication 6471006
Alcoholism contraindication 7200002
Bipolar disorder contraindication 13746004 DOID:3312
Neuroleptic malignant syndrome contraindication 15244003 DOID:14464
Jaundice contraindication 18165001
Cirrhosis of liver contraindication 19943007 DOID:5082
Orthostatic hypotension contraindication 28651003
Hypertensive disorder contraindication 38341003 DOID:10763
Alcoholic liver damage contraindication 41309000
Syndrome of inappropriate vasopressin secretion contraindication 55004003 DOID:3401
Acute nephropathy contraindication 58574008
Blood coagulation disorder contraindication 64779008 DOID:1247
Chronic hepatitis contraindication 76783007 DOID:2237
Hyperglycemia contraindication 80394007 DOID:4195
Epilepsy contraindication 84757009 DOID:1826
Hyponatremia contraindication 89627008
Inflammatory disease of liver contraindication 128241005
Liver function tests abnormal contraindication 166603001
Mania contraindication 231494001
Hypomania contraindication 231496004
Disease of liver contraindication 235856003 DOID:409
Retention of urine contraindication 267064002
Serotonin syndrome contraindication 371089000
Angle-closure glaucoma contraindication 392291006 DOID:13550
Gastrointestinal hypomotility contraindication 421807004




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.7 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Sodium-dependent serotonin transporter Transporter INHIBITOR Ki 9.62 CHEMBL CHEMBL
Sodium-dependent noradrenaline transporter Transporter INHIBITOR Ki 8.22 CHEMBL CHEMBL
5-hydroxytryptamine receptor 1A GPCR Ki 5.30 PDSP
5-hydroxytryptamine receptor 2A GPCR ANTAGONIST Ki 6.30 IUPHAR
5-hydroxytryptamine receptor 2B GPCR Ki 5.68 PDSP
5-hydroxytryptamine receptor 2C GPCR ANTAGONIST Ki 6 IUPHAR
5-hydroxytryptamine receptor 6 GPCR ANTAGONIST Ki 6.40 IUPHAR
5-hydroxytryptamine receptor 7 GPCR Ki 5.65 PDSP
Histamine H1 receptor GPCR Ki 5.64 PDSP
5-hydroxytryptamine receptor 1B GPCR Ki 5.40 PDSP
5-hydroxytryptamine receptor 1D GPCR Ki 5.52 PDSP
Sodium-dependent dopamine transporter Transporter Ki 6.62 CHEMBL
5-hydroxytryptamine receptor 1F GPCR Ki 5.35 PDSP
5-hydroxytryptamine receptor 1E GPCR Ki 5.43 PDSP
P2X purinoceptor 4 Ion channel IC50 5.23 CHEMBL
Serine hydroxymethyltransferase, mitochondrial Enzyme IC50 5.16 CHEMBL
Sodium-dependent serotonin transporter Transporter Ki 10.09 CHEMBL
Sodium-dependent dopamine transporter Transporter IC50 6.43 CHEMBL
5-hydroxytryptamine receptor 2A GPCR Ki 5.91 CHEMBL
5-hydroxytryptamine receptor 2C GPCR Ki 5.61 CHEMBL
Transporter Transporter Ki 8.52 CHEMBL

External reference:

IDSource
D01179 KEGG_DRUG
136434-34-9 SECONDARY_CAS_RN
4021477 VANDF
C0245561 UMLSCUI
29E PDB_CHEM_ID
CHEMBL1175 ChEMBL_ID
CHEMBL1200328 ChEMBL_ID
DB00476 DRUGBANK_ID
D000068736 MESH_DESCRIPTOR_UI
60835 PUBCHEM_CID
202 IUPHAR_LIGAND_ID
7012 INN_ID
O5TNM5N07U UNII
476250 RXNORM
18760 MMSL
208014 MMSL
33554 MMSL
59319 MMSL
d05355 MMSL
008705 NDDF
008707 NDDF
407032004 SNOMEDCT_US
407033009 SNOMEDCT_US
426892003 SNOMEDCT_US
CHEBI:31526 CHEBI
O5TNM5N07U INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Cymbalta HUMAN PRESCRIPTION DRUG LABEL 1 0002-3235 CAPSULE, DELAYED RELEASE 20 mg ORAL NDA 36 sections
Cymbalta HUMAN PRESCRIPTION DRUG LABEL 1 0002-3240 CAPSULE, DELAYED RELEASE 30 mg ORAL NDA 36 sections
Cymbalta HUMAN PRESCRIPTION DRUG LABEL 1 0002-3270 CAPSULE, DELAYED RELEASE 60 mg ORAL NDA 36 sections
Duloxetine HUMAN PRESCRIPTION DRUG LABEL 1 0228-2890 CAPSULE, DELAYED RELEASE PELLETS 20 mg ORAL ANDA 29 sections
Duloxetine HUMAN PRESCRIPTION DRUG LABEL 1 0228-2890 CAPSULE, DELAYED RELEASE PELLETS 20 mg ORAL ANDA 29 sections
Duloxetine HUMAN PRESCRIPTION DRUG LABEL 1 0228-2891 CAPSULE, DELAYED RELEASE PELLETS 30 mg ORAL ANDA 29 sections
Duloxetine HUMAN PRESCRIPTION DRUG LABEL 1 0228-2891 CAPSULE, DELAYED RELEASE PELLETS 30 mg ORAL ANDA 29 sections
Duloxetine HUMAN PRESCRIPTION DRUG LABEL 1 0228-2892 CAPSULE, DELAYED RELEASE PELLETS 60 mg ORAL ANDA 29 sections
Duloxetine HUMAN PRESCRIPTION DRUG LABEL 1 0228-2892 CAPSULE, DELAYED RELEASE PELLETS 60 mg ORAL ANDA 29 sections
Duloxetine HUMAN PRESCRIPTION DRUG LABEL 1 0615-8494 CAPSULE, DELAYED RELEASE 20 mg ORAL ANDA 25 sections
Duloxetine HUMAN PRESCRIPTION DRUG LABEL 1 0615-8495 CAPSULE, DELAYED RELEASE 30 mg ORAL ANDA 25 sections
Duloxetine HUMAN PRESCRIPTION DRUG LABEL 1 0615-8496 CAPSULE, DELAYED RELEASE 60 mg ORAL ANDA 25 sections
Cymbalta HUMAN PRESCRIPTION DRUG LABEL 1 21695-145 CAPSULE, DELAYED RELEASE 30 mg ORAL NDA 34 sections
Cymbalta HUMAN PRESCRIPTION DRUG LABEL 1 21695-146 CAPSULE, DELAYED RELEASE 60 mg ORAL NDA 34 sections
Cymbalta HUMAN PRESCRIPTION DRUG LABEL 1 21695-657 CAPSULE, DELAYED RELEASE 20 mg ORAL NDA 34 sections
Duloxetine Human Prescription Drug Label 1 25000-608 CAPSULE, DELAYED RELEASE 20 mg ORAL ANDA 35 sections
Duloxetine Human Prescription Drug Label 1 25000-609 CAPSULE, DELAYED RELEASE 30 mg ORAL ANDA 35 sections
Duloxetine Human Prescription Drug Label 1 25000-610 CAPSULE, DELAYED RELEASE 60 mg ORAL ANDA 35 sections
Duloxetine Human Prescription Drug Label 1 27241-097 CAPSULE, DELAYED RELEASE 20 mg ORAL ANDA 31 sections
Duloxetine Human Prescription Drug Label 1 27241-098 CAPSULE, DELAYED RELEASE 30 mg ORAL ANDA 31 sections
Duloxetine Human Prescription Drug Label 1 27241-099 CAPSULE, DELAYED RELEASE 60 mg ORAL ANDA 31 sections
Duloxetine Human Prescription Drug Label 1 27241-164 CAPSULE, DELAYED RELEASE 40 mg ORAL ANDA 31 sections
Duloxetine HUMAN PRESCRIPTION DRUG LABEL 1 31722-168 CAPSULE, DELAYED RELEASE 20 mg ORAL ANDA 31 sections
Duloxetine HUMAN PRESCRIPTION DRUG LABEL 1 31722-169 CAPSULE, DELAYED RELEASE 30 mg ORAL ANDA 31 sections
Duloxetine HUMAN PRESCRIPTION DRUG LABEL 1 31722-170 CAPSULE, DELAYED RELEASE 60 mg ORAL ANDA 31 sections
Duloxetine Hydrochloride Human Prescription Drug Label 1 33342-160 CAPSULE, DELAYED RELEASE 20 mg ORAL ANDA 31 sections
Duloxetine Hydrochloride Human Prescription Drug Label 1 33342-161 CAPSULE, DELAYED RELEASE 30 mg ORAL ANDA 31 sections
Duloxetine Hydrochloride Human Prescription Drug Label 1 33342-162 CAPSULE, DELAYED RELEASE 60 mg ORAL ANDA 31 sections
CYMBALTA HUMAN PRESCRIPTION DRUG LABEL 1 42549-646 CAPSULE, DELAYED RELEASE 30 mg ORAL NDA 34 sections
Duloxetine HUMAN PRESCRIPTION DRUG LABEL 1 42708-196 CAPSULE, DELAYED RELEASE 60 mg ORAL ANDA 25 sections