bupropion 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
anorexics 435 34911-55-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • bupropion
  • (+/-)-Bupropion
  • amfebutamon
  • amfebutamone
  • aplenzin
  • elontril
  • bupropion hydrochloride
  • bupropion hydrobromide
  • bupropion HCl
  • wellbutrin
A propiophenone-derived antidepressant and antismoking agent that inhibits the uptake of DOPAMINE.
  • Molecular weight: 239.74
  • Formula: C13H18ClNO
  • CLOGP: 3.21
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 1
  • TPSA: 29.10
  • ALOGS: -3.54
  • ROTB: 4
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.30 g O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 312 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 31.28 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Approvals:

DateAgencyCompanyOrphan
Dec. 30, 1985 FDA GLAXOSMITHKLINE

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 3414.53 9.96 2728 134399 131105 56023835
Toxicity to various agents 788.65 9.96 1708 135419 222856 55932084
Depression 617.00 9.96 1357 135770 178760 55976180
Overdose 472.00 9.96 890 136237 104940 56050000
Intentional overdose 460.26 9.96 690 136437 67427 56087513
Anxiety 417.76 9.96 1223 135904 191949 55962991
Generalised tonic-clonic seizure 417.60 9.96 420 136707 27146 56127794
Seizure 404.77 9.96 922 136205 124197 56030743
Suicidal ideation 377.38 9.96 576 136551 57166 56097774
Suspected suicide 336.47 9.96 193 136934 5273 56149667
Cardio-respiratory arrest 329.73 9.96 529 136598 54792 56100148
Product substitution issue 294.98 9.96 261 136866 14338 56140602
Serotonin syndrome 283.20 9.96 336 136791 26154 56128786
Suicide attempt 259.60 9.96 488 136639 57348 56097592
Electrocardiogram QRS complex prolonged 243.74 9.96 157 136970 5310 56149630
Cardiac arrest 232.65 9.96 593 136534 85721 56069219
Temperature regulation disorder 228.55 9.96 140 136987 4328 56150612
Agitation 218.90 9.96 446 136681 55590 56099350
Status epilepticus 213.48 9.96 222 136905 14919 56140021
Irritability 183.20 9.96 288 136839 29300 56125640
Respiratory arrest 177.15 9.96 289 136838 30336 56124604
Swelling 176.81 9.96 194 136933 239577 55915363
Sleep apnoea syndrome 173.03 9.96 262 136865 25799 56129141
Drug withdrawal syndrome 170.33 9.96 259 136868 25598 56129342
Mydriasis 168.19 9.96 169 136958 10902 56144038
Food allergy 155.26 9.96 146 136981 8678 56146262
Pemphigus 153.06 9.96 97 137030 157115 55997825
Neutropenia 152.06 9.96 99 137028 158068 55996872
Coeliac disease 151.91 9.96 155 136972 10184 56144756
Sensitisation 149.46 9.96 85 137042 2283 56152657
Hyperhidrosis 148.90 9.96 536 136591 93552 56061388
Arthropathy 148.77 9.96 161 136966 200114 55954826
Systemic lupus erythematosus 146.10 9.96 134 136993 179944 55974996
Tremor 145.74 9.96 633 136494 120456 56034484
Polycystic ovaries 144.85 9.96 94 137033 3220 56151720
Anaemia 142.53 9.96 272 136855 267239 55887701
Thrombocytopenia 139.69 9.96 79 137048 136145 56018795
Poisoning 137.70 9.96 163 136964 12650 56142290
Pyrexia 137.47 9.96 540 136587 418233 55736707
White blood cell count abnormal 132.91 9.96 112 137015 5755 56149185
Electrocardiogram QT prolonged 132.70 9.96 361 136766 54227 56100713
Asthma 131.51 9.96 584 136543 112186 56042754
Sinus tachycardia 127.37 9.96 210 136917 22234 56132706
Acute kidney injury 127.19 9.96 246 136881 240517 55914423
Febrile neutropenia 125.39 9.96 50 137077 105495 56049445
Immunodeficiency 124.05 9.96 174 136953 15983 56138957
Ejection fraction 123.11 9.96 67 137060 1648 56153292
Helicobacter infection 121.60 9.96 17 137110 73251 56081689
Peripheral swelling 119.54 9.96 245 136882 234481 55920459
Glossodynia 118.33 9.96 118 137009 152340 56002600
Duodenal ulcer perforation 113.09 9.96 16 137111 68326 56086614
Headache 110.63 9.96 1943 135184 557101 55597839
Joint swelling 110.15 9.96 351 136776 289449 55865491
Insomnia 107.13 9.96 817 136310 191043 55963897
Pancytopenia 107.07 9.96 41 137086 88674 56066266
Hand deformity 105.62 9.96 103 137024 134389 56020551
Muscle injury 103.59 9.96 6 137121 52494 56102446
Drug hypersensitivity 101.73 9.96 1071 136056 274134 55880806
Withdrawal syndrome 99.76 9.96 169 136958 18293 56136647
Cardiac failure 98.97 9.96 38 137089 82055 56072885
Lower respiratory tract infection 97.18 9.96 82 137045 114712 56040228
Therapeutic response unexpected 96.07 9.96 159 136968 16885 56138055
Drug abuse 95.95 9.96 372 136755 67238 56087702
Maternal exposure during pregnancy 95.50 9.96 199 136928 189354 55965586
Folliculitis 95.49 9.96 11 137116 54968 56099972
Blister 94.38 9.96 76 137051 108811 56046129
Anger 93.04 9.96 128 136999 11544 56143396
Feeling abnormal 92.76 9.96 600 136527 133002 56021938
Infusion related reaction 92.63 9.96 235 136892 208696 55946244
Foot deformity 89.89 9.96 187 136940 23638 56131302
General physical health deterioration 88.60 9.96 175 136952 169835 55985105
Treatment failure 86.57 9.96 178 136949 170214 55984726
Infarction 86.30 9.96 61 137066 2410 56152530
Joint dislocation 84.71 9.96 144 136983 15629 56139311
Retinitis 84.28 9.96 75 137052 4149 56150791
Malignant neoplasm progression 83.95 9.96 37 137090 73550 56081390
Exposure via ingestion 83.73 9.96 63 137064 2745 56152195
Memory impairment 83.22 9.96 424 136703 86133 56068807
Crying 82.91 9.96 170 136957 21270 56133670
Exostosis 81.02 9.96 137 136990 14806 56140134
Product odour abnormal 78.27 9.96 43 137084 1078 56153862
Myoclonus 77.98 9.96 136 136991 15067 56139873
Tardive dyskinesia 77.89 9.96 97 137030 7934 56147006
Dyspnoea 76.05 9.96 1003 136124 591574 55563366
Sympathomimetic effect 74.27 9.96 19 137108 39 56154901
Alopecia 73.97 9.96 416 136711 293042 55861898
Rash 73.74 9.96 807 136320 492240 55662700
Atrial fibrillation 71.80 9.96 96 137031 108801 56046139
Pericarditis 70.83 9.96 97 137030 108826 56046114
Rhinitis allergic 70.68 9.96 95 137032 8379 56146561
Migraine 70.46 9.96 406 136721 86391 56068549
Mental status changes 70.13 9.96 226 136901 37275 56117665
Abdominal discomfort 69.36 9.96 394 136733 276880 55878060
Lupus-like syndrome 68.79 9.96 115 137012 12312 56142628
Bursitis 68.60 9.96 184 136943 27398 56127542
Disturbance in attention 67.22 9.96 203 136924 32337 56122603
Pulseless electrical activity 66.78 9.96 84 137043 6940 56148000
Gastrointestinal disorder 65.88 9.96 108 137019 112594 56042346
Postmortem blood drug level increased 65.55 9.96 31 137096 561 56154379
Diarrhoea 65.34 9.96 1129 135998 637378 55517562
Postictal state 64.66 9.96 36 137091 927 56154013
Disease progression 63.16 9.96 99 137028 105074 56049866
Impaired healing 62.02 9.96 72 137055 86769 56068171
Bone erosion 61.80 9.96 122 137005 14852 56140088
Product residue present 61.47 9.96 60 137067 3735 56151205
Platelet count decreased 61.20 9.96 103 137024 106280 56048660
Panic attack 60.85 9.96 146 136981 20301 56134639
Cholecystitis chronic 60.48 9.96 95 137032 9653 56145287
Stomatitis 59.83 9.96 128 136999 120682 56034258
Bronchial neoplasm 59.59 9.96 27 137100 441 56154499
Cerebral venous thrombosis 59.45 9.96 44 137083 1869 56153071
Hepatic cirrhosis 59.21 9.96 148 136979 21115 56133825
Nicotine dependence 57.41 9.96 30 137097 678 56154262
Bipolar disorder 57.24 9.96 81 137046 7499 56147441
Nephrectomy 56.96 9.96 36 137091 1177 56153763
Bone marrow failure 56.52 9.96 3 137124 28283 56126657
Mental disorder 56.24 9.96 155 136972 23449 56131491
Sepsis 56.15 9.96 165 136962 139675 56015265
Hallucinations, mixed 55.53 9.96 61 137066 4363 56150577
Bronchial haemorrhage 55.11 9.96 27 137100 530 56154410
Anti-cyclic citrullinated peptide antibody positive 54.41 9.96 98 137029 98502 56056438
Hyperkalaemia 54.30 9.96 28 137099 50837 56104103
Tachycardia 54.14 9.96 442 136685 105434 56049506
Sleep-related eating disorder 53.83 9.96 30 137097 774 56154166
Psoriasis 53.50 9.96 398 136729 92294 56062646
Multiple organ dysfunction syndrome 53.49 9.96 31 137096 52739 56102201
Carpal tunnel syndrome 53.40 9.96 129 136998 18015 56136925
Hepatocellular injury 52.39 9.96 3 137124 26511 56128429
Synovitis 52.12 9.96 209 136918 161096 55993844
Asthma exercise induced 51.44 9.96 21 137106 262 56154678
Areflexia 51.40 9.96 48 137079 2827 56152113
Weight increased 51.27 9.96 815 136312 228888 55926052
Brain injury 51.12 9.96 70 137057 6285 56148655
Hyponatraemia 50.75 9.96 108 137019 102031 56052909
Hallucination 50.22 9.96 245 136882 48904 56106036
Factor V Leiden mutation 49.93 9.96 19 137108 194 56154746
C-reactive protein abnormal 49.69 9.96 14 137113 36795 56118145
Mucosal inflammation 49.66 9.96 21 137106 42789 56112151
Discomfort 49.47 9.96 178 136949 141583 56013357
Neutrophil count decreased 49.47 9.96 30 137097 49792 56105148
Rubber sensitivity 49.45 9.96 40 137087 1940 56153000
Renal impairment 49.39 9.96 75 137052 80638 56074302
Sleep disorder due to general medical condition, insomnia type 49.09 9.96 22 137105 43316 56111624
Nasal turbinate hypertrophy 48.82 9.96 27 137100 686 56154254
Persistent genital arousal disorder 48.57 9.96 21 137106 305 56154635
Major depression 48.57 9.96 75 137052 7509 56147431
Emotional distress 48.26 9.96 171 136956 29592 56125348
Rash erythematous 47.36 9.96 198 136929 37023 56117917
Haemoglobin decreased 47.09 9.96 168 136959 133969 56020971
Hepatic function abnormal 46.92 9.96 13 137114 34545 56120395
Wound 46.65 9.96 177 136950 138627 56016313
Cardiogenic shock 45.85 9.96 114 137013 16211 56138729
Irritable bowel syndrome 45.47 9.96 60 137067 68398 56086542
Endometrial ablation 45.37 9.96 28 137099 877 56154063
Liver disorder 45.06 9.96 26 137101 44344 56110596
Therapeutic product effect incomplete 45.04 9.96 425 136702 105606 56049334
Thermal burn 45.00 9.96 61 137066 5424 56149516
Hypothyroidism 44.61 9.96 198 136929 37998 56116942
Nasopharyngitis 44.55 9.96 335 136792 220624 55934316
Leukopenia 44.30 9.96 65 137062 70875 56084065
Fibromyalgia 44.00 9.96 272 136855 59331 56095609
Multiple sclerosis relapse 43.86 9.96 221 136906 44682 56110258
Arthralgia 43.81 9.96 911 136216 500758 55654182
Mood altered 43.72 9.96 99 137028 13256 56141684
Hostility 43.64 9.96 36 137091 1795 56153145
Brugada syndrome 43.53 9.96 20 137107 338 56154602
Thinking abnormal 43.47 9.96 83 137044 9858 56145082
Blood test abnormal 43.23 9.96 96 137031 12688 56142252
Intentional product misuse 43.15 9.96 243 136884 51261 56103679
Oesophageal spasm 42.97 9.96 43 137084 2759 56152181
Cholestasis 42.91 9.96 7 137120 26906 56128034
Libido increased 42.63 9.96 31 137096 1281 56153659
Affective disorder 42.50 9.96 60 137067 5543 56149397
Hyperreflexia 42.48 9.96 58 137069 5192 56149748
Depressed mood 42.10 9.96 188 136939 36171 56118769
Fluid retention 41.96 9.96 250 136877 53828 56101112
Product complaint 41.69 9.96 90 137037 11670 56143270
White blood cell count decreased 41.48 9.96 162 136965 125828 56029112
Gastrointestinal haemorrhage 41.44 9.96 76 137051 75875 56079065
Nightmare 40.59 9.96 111 137016 16715 56138225
Lung disorder 40.44 9.96 41 137086 52556 56102384
Pruritus 40.06 9.96 537 136590 316086 55838854
Vertigo 39.63 9.96 248 136879 54324 56100616
Pre-existing condition improved 39.01 9.96 67 137060 7331 56147609
Hallucination, auditory 38.37 9.96 86 137041 11438 56143502
Muscle twitching 38.04 9.96 106 137021 16136 56138804
Abnormal dreams 37.88 9.96 77 137050 9572 56145368
Impulse-control disorder 37.86 9.96 23 137104 700 56154240
Upper respiratory tract infection 37.73 9.96 300 136827 70988 56083952
Sleep disorder due to a general medical condition 37.44 9.96 74 137053 9016 56145924
Pleural effusion 37.17 9.96 97 137030 85383 56069557
Pneumonia 37.07 9.96 734 136393 406364 55748576
Bruxism 36.90 9.96 42 137085 3124 56151816
Bronchial disorder 36.29 9.96 27 137100 1156 56153784
Oesophageal pain 35.74 9.96 42 137085 3233 56151707
Laryngitis 35.72 9.96 94 137033 13836 56141104
Hypokalaemia 35.36 9.96 115 137012 94322 56060618
Endometriosis 35.14 9.96 50 137077 4652 56150288
Akathisia 35.11 9.96 70 137057 8582 56146358
Gastrooesophageal reflux disease 35.00 9.96 333 136794 82924 56072016
Hypoglycaemia 34.98 9.96 51 137076 55764 56099176
Sleep paralysis 34.71 9.96 20 137107 551 56154389
Burning sensation 33.93 9.96 219 136908 48477 56106463
Pupil fixed 33.70 9.96 30 137097 1660 56153280
Hepatic failure 33.47 9.96 20 137107 33466 56121474
Dizziness 33.25 9.96 1173 135954 374967 55779973
Septic shock 33.08 9.96 61 137066 60774 56094166
Mania 32.93 9.96 81 137046 11439 56143501
Treatment noncompliance 32.88 9.96 162 136965 32461 56122479
Feeling jittery 32.65 9.96 83 137044 11963 56142977
Drug eruption 32.61 9.96 11 137116 25752 56129188
Stress 32.32 9.96 250 136877 58660 56096280
Vision blurred 32.06 9.96 326 136801 82617 56072323
Choreoathetosis 31.87 9.96 18 137109 477 56154463
Death 31.85 9.96 613 136514 340813 55814127
Liver injury 31.74 9.96 33 137094 41815 56113125
Libido decreased 31.61 9.96 34 137093 2374 56152566
Obsessive-compulsive disorder 31.60 9.96 42 137085 3664 56151276
Tinnitus 31.58 9.96 151 136976 29891 56125049
Epistaxis 31.54 9.96 73 137054 66950 56087990
Ejection fraction abnormal 31.30 9.96 24 137103 1076 56153864
Sputum purulent 31.16 9.96 23 137104 973 56153967
International normalised ratio increased 30.91 9.96 37 137090 44004 56110936
Drug intolerance 30.69 9.96 457 136670 264361 55890579
Drug screen positive 30.69 9.96 40 137087 3424 56151516
Rheumatic fever 30.57 9.96 16 137111 28811 56126129
Economic problem 30.55 9.96 30 137097 1881 56153059
Ascites 30.33 9.96 28 137099 37516 56117424
Gamma-glutamyltransferase increased 30.32 9.96 19 137108 30986 56123954
Hypercalcaemia 30.22 9.96 12 137115 25399 56129541
Tachyphrenia 30.09 9.96 25 137102 1259 56153681
Plasma cell myeloma 29.85 9.96 42 137085 46604 56108336
Anti-neutrophil cytoplasmic antibody positive vasculitis 29.66 9.96 34 137093 2549 56152391
Anorgasmia 29.65 9.96 18 137109 547 56154393
Gambling disorder 29.26 9.96 24 137103 1187 56153753
Myelodysplastic syndrome 29.20 9.96 3 137124 16403 56138537
Binge eating 28.98 9.96 16 137111 405 56154535
Cerebral haemorrhage 28.71 9.96 17 137110 28589 56126351
Anhedonia 28.65 9.96 70 137057 9844 56145096
Toxic epidermal necrolysis 28.63 9.96 9 137118 22033 56132907
Dyskinesia 28.24 9.96 143 136984 28965 56125975
Product quality issue 28.09 9.96 152 136975 31584 56123356
Somnolence 27.94 9.96 556 136571 162857 55992083
Amnesia 27.91 9.96 201 136926 46121 56108819
Renal disorder 27.72 9.96 144 136983 29461 56125479
Jaundice 27.71 9.96 16 137111 27278 56127662
Central nervous system necrosis 27.63 9.96 11 137116 128 56154812
Urine sodium increased 27.49 9.96 10 137117 89 56154851
Automatism 27.39 9.96 9 137118 57 56154883
Restless legs syndrome 27.16 9.96 97 137030 16850 56138090
Renal failure 27.04 9.96 158 136969 110342 56044598
Electroencephalogram abnormal 26.99 9.96 38 137089 3501 56151439
Joint stiffness 26.98 9.96 163 136964 35262 56119678
Secondary immunodeficiency 26.71 9.96 23 137104 1217 56153723
Infection 26.59 9.96 336 136791 199870 55955070
Rash maculo-papular 26.54 9.96 19 137108 28888 56126052
Nervousness 26.38 9.96 140 136987 28875 56126065
Asthenia 26.12 9.96 636 136491 342337 55812603
Brain death 25.73 9.96 34 137093 2949 56151991
Ventricular tachycardia 25.62 9.96 95 137032 16806 56138134
Mucosal dryness 25.56 9.96 31 137096 2467 56152473
Melaena 25.44 9.96 19 137108 28271 56126669
Sexual dysfunction 25.28 9.96 36 137091 3352 56151588
Decreased interest 25.18 9.96 34 137093 3012 56151928
Urine osmolarity increased 25.14 9.96 10 137117 116 56154824
Reversible cerebral vasoconstriction syndrome 25.14 9.96 30 137097 2347 56152593
Haematemesis 24.99 9.96 20 137107 28738 56126202
Agranulocytosis 24.89 9.96 12 137115 22647 56132293
Product dose omission issue 24.86 9.96 664 136463 204089 55950851
Syncope 24.76 9.96 158 136969 108041 56046899
Dyspnoea exertional 24.59 9.96 61 137066 54628 56100312
Neoplasm progression 24.56 9.96 25 137102 31991 56122949
Osteonecrosis of jaw 24.52 9.96 27 137100 33331 56121609
Multiple sclerosis 24.50 9.96 133 136994 27669 56127271
Thalamic infarction 24.39 9.96 15 137112 467 56154473
Off label use 24.22 9.96 1108 136019 555072 55599868
Blood lactate dehydrogenase increased 24.20 9.96 10 137117 20665 56134275
Unresponsive to stimuli 24.18 9.96 146 136981 31579 56123361
Feeling of despair 24.15 9.96 28 137099 2125 56152815
Attention deficit hyperactivity disorder 24.06 9.96 31 137096 2623 56152317
Macular degeneration 24.06 9.96 8 137119 18900 56136040
Ill-defined disorder 23.94 9.96 86 137041 68457 56086483
Post-traumatic stress disorder 23.80 9.96 41 137086 4497 56150443
Large intestine anastomosis 23.75 9.96 7 137120 29 56154911
Affect lability 23.63 9.96 66 137061 10059 56144881
Posterior reversible encephalopathy syndrome 23.63 9.96 5 137122 15955 56138985
Adrenergic syndrome 23.56 9.96 7 137120 30 56154910
Soft tissue injury 23.54 9.96 24 137103 1575 56153365
Lactic acidosis 23.45 9.96 31 137096 35315 56119625
Erythema dyschromicum perstans 23.42 9.96 8 137119 58 56154882
Swollen joint count increased 23.40 9.96 15 137112 24169 56130771
Drug specific antibody 23.24 9.96 27 137100 2053 56152887
Hepatotoxicity 23.14 9.96 25 137102 31128 56123812
Dissociation 23.13 9.96 30 137097 2555 56152385
Haemorrhage 23.02 9.96 66 137061 56331 56098609
Supraventricular tachycardia 22.97 9.96 78 137049 13213 56141727
Nausea 22.92 9.96 2159 134968 762019 55392921
Dysphemia 22.72 9.96 29 137098 2431 56152509
Myoglobinuria 22.66 9.96 12 137115 279 56154661
Hip arthroplasty 22.57 9.96 37 137090 38586 56116354
Drug tolerance decreased 22.51 9.96 3 137124 13408 56141532
Interstitial lung disease 22.40 9.96 68 137059 56995 56097945
Hypomagnesaemia 22.24 9.96 17 137110 24998 56129942
Peritonitis 22.17 9.96 6 137121 16196 56138744
Oppositional defiant disorder 22.06 9.96 7 137120 39 56154901
Accidental exposure to product by child 21.78 9.96 20 137107 1153 56153787
Rhonchi 21.67 9.96 28 137099 2376 56152564
Hepatitis 21.61 9.96 33 137094 35408 56119532
Heart rate decreased 21.56 9.96 41 137086 40386 56114554
Complication of device insertion 21.45 9.96 48 137079 6376 56148564
Rheumatoid arthritis 21.43 9.96 740 136387 381864 55773076
Mood swings 21.23 9.96 89 137038 16658 56138282
Paranoia 21.23 9.96 66 137061 10678 56144262
Product use issue 21.21 9.96 322 136805 185719 55969221
Cardiac disorder 21.03 9.96 187 136940 45700 56109240
Compulsive shopping 20.99 9.96 16 137111 711 56154229
Hypotonic urinary bladder 20.74 9.96 5 137122 7 56154933
Corneal reflex decreased 20.74 9.96 9 137118 132 56154808
Rhinitis 20.69 9.96 58 137069 8858 56146082
Dystonia 20.68 9.96 72 137055 12349 56142591
Oedema 20.65 9.96 116 137011 81804 56073136
Pneumonitis 20.61 9.96 28 137099 31536 56123404
Impaired work ability 20.51 9.96 80 137047 14492 56140448
Cerebral infarction 20.39 9.96 15 137112 22490 56132450
Disseminated intravascular coagulation 20.38 9.96 9 137118 17876 56137064
Solar urticaria 20.34 9.96 7 137120 52 56154888
Urine amphetamine positive 20.34 9.96 7 137120 52 56154888
Biliary dyskinesia 20.26 9.96 28 137099 2535 56152405
Metastases to liver 20.06 9.96 14 137113 21572 56133368
Narcolepsy 19.91 9.96 20 137107 1289 56153651
Sternal fracture 19.88 9.96 25 137102 2065 56152875
Musculoskeletal pain 19.87 9.96 116 137011 81036 56073904
Anticholinergic syndrome 19.79 9.96 24 137103 1910 56153030
Neuropathy peripheral 19.77 9.96 158 136969 102735 56052205
Liver function test abnormal 19.72 9.96 52 137075 45619 56109321
Apathy 19.71 9.96 53 137074 7901 56147039
Caput succedaneum 19.63 9.96 5 137122 10 56154930
Self esteem decreased 19.52 9.96 14 137113 566 56154374
Emotional disorder 19.38 9.96 70 137057 12225 56142715
Tongue biting 19.35 9.96 20 137107 1334 56153606
Cardiomyopathy acute 19.26 9.96 10 137117 223 56154717
Respiratory failure 19.19 9.96 144 136983 94918 56060022
Mass excision 19.12 9.96 11 137116 302 56154638
Blood creatinine increased 18.91 9.96 116 137011 80075 56074865
Gallbladder disorder 18.85 9.96 88 137039 17246 56137694
Blood pressure systolic increased 18.79 9.96 45 137082 40791 56114149
Upper gastrointestinal haemorrhage 18.78 9.96 9 137118 17045 56137895
Alcoholism 18.78 9.96 25 137102 2184 56152756
Sexually inappropriate behaviour 18.58 9.96 8 137119 115 56154825
Femur fracture 18.32 9.96 43 137084 39252 56115688
Dysphoria 18.25 9.96 38 137089 4804 56150136
Tenosynovitis 18.25 9.96 4 137123 12457 56142483
Sensitivity to weather change 18.22 9.96 46 137081 6603 56148337
Haemoglobin urine 18.15 9.96 8 137119 122 56154818
Job dissatisfaction 18.13 9.96 6 137121 39 56154901
Somnambulism 18.08 9.96 39 137088 5053 56149887
Drug tolerance 18.05 9.96 43 137084 5951 56148989
Skin necrosis 18.04 9.96 4 137123 12357 56142583
Urinary tract infection 18.01 9.96 447 136680 240066 55914874
Drug dependence 18.01 9.96 105 137022 22428 56132512
Clonus 17.99 9.96 35 137092 4214 56150726
Haemangioma congenital 17.91 9.96 12 137115 434 56154506
Uterine perforation 17.82 9.96 45 137082 6460 56148480
Post-traumatic neck syndrome 17.77 9.96 23 137104 1955 56152985
Premature delivery 17.68 9.96 24 137103 27036 56127904
Cough 17.66 9.96 490 136637 259471 55895469
Blood bilirubin increased 17.64 9.96 34 137093 33320 56121620
Oscillopsia 17.64 9.96 8 137119 131 56154809
Drug titration error 17.47 9.96 14 137113 670 56154270
Skin ulcer 17.41 9.96 43 137084 38565 56116375
Euphoric mood 17.37 9.96 35 137092 4323 56150617
Liver function test increased 17.34 9.96 26 137101 28107 56126833
Product coating issue 17.27 9.96 6 137121 46 56154894
Device dislocation 17.20 9.96 104 137023 22502 56132438
Loss of libido 17.20 9.96 18 137109 1218 56153722
Knee arthroplasty 17.19 9.96 53 137074 44206 56110734
Acute myeloid leukaemia 17.15 9.96 10 137117 16962 56137978
Premature baby 17.14 9.96 13 137114 19192 56135748
Sedation 16.99 9.96 144 136983 34710 56120230
Infusion site scar 16.97 9.96 11 137116 376 56154564
Forced expiratory volume decreased 16.90 9.96 36 137091 4624 56150316
Cortisol increased 16.79 9.96 11 137116 383 56154557
Herpes zoster 16.76 9.96 112 137015 75777 56079163
Dermatillomania 16.76 9.96 8 137119 148 56154792
Cardiac failure congestive 16.71 9.96 135 136992 87585 56067355
Metastases to bone 16.42 9.96 14 137113 19494 56135446
Pulmonary hypertension 16.23 9.96 40 137087 35904 56119036
Right ventricular systolic pressure decreased 16.20 9.96 5 137122 25 56154915
Exposure via breast milk 16.17 9.96 21 137106 1791 56153149
Iron deficiency anaemia 16.16 9.96 12 137115 17907 56137033
Subacute cutaneous lupus erythematosus 16.13 9.96 24 137103 2325 56152615
Hypertensive crisis 16.09 9.96 7 137120 14029 56140911
Abnormal behaviour 15.90 9.96 94 137033 20178 56134762
Pulmonary arterial hypertension 15.85 9.96 25 137102 26478 56128462
Restlessness 15.81 9.96 115 137012 26471 56128469
Polyneuropathy 15.79 9.96 6 137121 13044 56141896
Gastrointestinal sounds abnormal 15.70 9.96 31 137096 3774 56151166
Encephalopathy 15.69 9.96 143 136984 35182 56119758
Haematuria 15.63 9.96 26 137101 26961 56127979
Vomiting 15.28 9.96 1027 136100 497201 55657739
Device placement issue 15.28 9.96 15 137112 940 56154000
Angina pectoris 15.25 9.96 28 137099 27948 56126992
Contraindicated product administered 15.11 9.96 342 136785 185944 55968996
Contusion 15.07 9.96 221 136906 128209 56026731
Orgasmic sensation decreased 15.06 9.96 3 137124 0 56154940
Generalised anxiety disorder 15.01 9.96 21 137106 1923 56153017
Hypervolaemia 14.85 9.96 26 137101 26432 56128508
Panniculitis 14.74 9.96 3 137124 9839 56145101
Wound infection fungal 14.69 9.96 7 137120 129 56154811
Rheumatoid nodule 14.67 9.96 9 137118 14848 56140092
Ulcer 14.63 9.96 20 137107 22465 56132475
Ventricular tachyarrhythmia 14.59 9.96 7 137120 131 56154809
Snoring 14.56 9.96 29 137098 3552 56151388
Dysgraphia 14.49 9.96 25 137102 2745 56152195
Palmar-plantar erythrodysaesthesia syndrome 14.46 9.96 18 137109 21047 56133893
Breast cancer metastatic 14.42 9.96 10 137117 15459 56139481
Sputum discoloured 14.42 9.96 71 137056 14221 56140719
Balance disorder 14.31 9.96 264 136863 76256 56078684
Decorticate posture 14.25 9.96 9 137118 294 56154646
Colitis 14.24 9.96 53 137074 41758 56113182
Visual impairment 14.22 9.96 257 136870 73945 56080995
Cannabinoid hyperemesis syndrome 14.21 9.96 5 137122 40 56154900
Lymphoedema 14.17 9.96 57 137070 10473 56144467
Hypertonic bladder 14.15 9.96 27 137100 3205 56151735
Impaired driving ability 14.12 9.96 31 137096 4065 56150875
Pericardial effusion 14.11 9.96 28 137099 27147 56127793
Homicidal ideation 14.02 9.96 19 137108 1689 56153251
Dyspareunia 13.98 9.96 22 137105 2238 56152702
Chronic fatigue syndrome 13.92 9.96 15 137112 1050 56153890
Product solubility abnormal 13.87 9.96 13 137114 769 56154171
Obesity 13.86 9.96 98 137029 22350 56132590
Cerebrovascular accident 13.77 9.96 165 136962 99105 56055835
Gestational diabetes 13.65 9.96 47 137080 8017 56146923
Poor personal hygiene 13.64 9.96 9 137118 317 56154623
Abscess sterile 13.51 9.96 5 137122 47 56154893
Infusion site discomfort 13.49 9.96 15 137112 1087 56153853
Ankle fracture 13.47 9.96 77 137050 16326 56138614
Pelvic pain 13.46 9.96 61 137066 11806 56143134
Cholelithiasis 13.33 9.96 151 136976 39313 56115627
Pallor 13.31 9.96 24 137103 24125 56130815
Antidepressant discontinuation syndrome 13.30 9.96 4 137123 18 56154922
Clostridium difficile infection 13.30 9.96 29 137098 27169 56127771
False positive investigation result 13.29 9.96 11 137116 551 56154389
Wrong technique in product usage process 13.17 9.96 207 136920 57961 56096979
Pupillary reflex impaired 13.12 9.96 20 137107 1980 56152960
Incorrect route of product administration 13.11 9.96 93 137034 21236 56133704
Basal cell carcinoma 13.08 9.96 26 137101 25195 56129745
Shock haemorrhagic 13.03 9.96 3 137124 9030 56145910
Brain stem syndrome 13.02 9.96 9 137118 343 56154597
Coagulopathy 12.84 9.96 16 137111 18700 56136240
Drug reaction with eosinophilia and systemic symptoms 12.71 9.96 35 137092 30269 56124671
Mental impairment 12.69 9.96 63 137064 12659 56142281
Bipolar I disorder 12.67 9.96 18 137109 1672 56153268
Bronchiectasis 12.64 9.96 6 137121 11428 56143512
Food craving 12.62 9.96 17 137110 1502 56153438
Stoma site ulcer 12.62 9.96 8 137119 263 56154677
Blood pressure fluctuation 12.58 9.96 53 137074 40307 56114633
Anaphylactic shock 12.54 9.96 21 137106 21719 56133221
Executive dysfunction 12.51 9.96 7 137120 182 56154758
Diverticulitis 12.50 9.96 45 137082 35807 56119133
Flat affect 12.49 9.96 16 137111 1346 56153594
Depressive symptom 12.44 9.96 27 137100 3514 56151426
Bezoar 12.44 9.96 16 137111 1352 56153588
Carbon monoxide poisoning 12.41 9.96 7 137120 185 56154755
Device expulsion 12.40 9.96 121 137006 30328 56124612
Hypoaesthesia 12.39 9.96 441 136686 141050 56013890
Therapeutic product effect decreased 12.39 9.96 316 136811 169136 55985804
Personality disorder 12.35 9.96 34 137093 5139 56149801
Yawning 12.32 9.96 14 137113 1039 56153901
Right ventricular failure 12.32 9.96 13 137114 16366 56138574
Parkinsonism 12.31 9.96 51 137076 9495 56145445
Insurance issue 12.29 9.96 28 137099 3764 56151176
Haemophagocytic lymphohistiocytosis 12.27 9.96 4 137123 9568 56145372
Muscle rigidity 12.22 9.96 55 137072 10616 56144324
Pain in jaw 12.21 9.96 53 137074 39983 56114957
Pancreatitis acute 12.11 9.96 27 137100 25097 56129843
Orthostatic hypotension 12.03 9.96 41 137086 33158 56121782
Injection site mass 11.99 9.96 76 137051 16717 56138223
Haematoma 11.97 9.96 39 137088 31980 56122960
Drug ineffective 11.96 9.96 2013 135114 916976 55237964
Embedded device 11.89 9.96 24 137103 2969 56151971
Road traffic accident 11.88 9.96 112 137015 27815 56127125
Arthritis 11.87 9.96 323 136804 99529 56055411
Device related infection 11.84 9.96 22 137105 21858 56133082
Tooth fracture 11.79 9.96 53 137074 10223 56144717
Galactorrhoea 11.79 9.96 28 137099 3867 56151073
Social anxiety disorder 11.79 9.96 9 137118 401 56154539
Pituitary hyperplasia 11.78 9.96 3 137124 6 56154934
Blood pressure orthostatic abnormal 11.78 9.96 3 137124 6 56154934
Metastases to lung 11.71 9.96 7 137120 11711 56143229
Drug resistance 11.70 9.96 20 137107 20522 56134418
Hepatic encephalopathy 11.66 9.96 5 137122 10105 56144835
Bone pain 11.62 9.96 73 137054 50112 56104828
Ankle arthroplasty 11.62 9.96 16 137111 1444 56153496
Fear 11.61 9.96 69 137058 14839 56140101
Blood potassium increased 11.59 9.96 15 137112 17246 56137694
Hypertension 11.59 9.96 716 136411 243562 55911378
Pulmonary oedema 11.53 9.96 75 137052 51068 56103872
Drug screen false positive 11.51 9.96 12 137115 808 56154132
Suicidal behaviour 11.49 9.96 21 137106 2412 56152528
Homeless 11.48 9.96 5 137122 74 56154866
Bipolar II disorder 11.45 9.96 8 137119 310 56154630
Distractibility 11.44 9.96 9 137118 419 56154521
Disorientation 11.43 9.96 138 136989 36475 56118465
Tri-iodothyronine free decreased 11.43 9.96 8 137119 311 56154629
Rectal haemorrhage 11.41 9.96 57 137070 41410 56113530
Bankruptcy 11.37 9.96 4 137123 32 56154908
Inadequate analgesia 11.31 9.96 22 137105 2649 56152291
Illusion 11.27 9.96 13 137114 981 56153959
Electrocardiogram QRS complex shortened 11.26 9.96 9 137118 429 56154511
Impulsive behaviour 11.23 9.96 16 137111 1491 56153449
Panic disorder 11.14 9.96 21 137106 2470 56152470
Priapism 11.13 9.96 5 137122 80 56154860
Intermenstrual bleeding 11.07 9.96 40 137087 6987 56147953
Partner stress 11.04 9.96 8 137119 329 56154611
Panic reaction 11.02 9.96 27 137100 3803 56151137
Injury 11.02 9.96 206 136921 59645 56095295
Gaze palsy 11.01 9.96 15 137112 1340 56153600
Essential tremor 10.97 9.96 13 137114 1010 56153930
Diabetes mellitus 10.95 9.96 185 136942 52550 56102390
Body temperature decreased 10.90 9.96 17 137110 18091 56136849
Blood pressure diastolic decreased 10.84 9.96 19 137108 19304 56135636
Haemolytic anaemia 10.84 9.96 5 137122 9680 56145260
Nystagmus 10.79 9.96 35 137092 5790 56149150
Convulsive threshold lowered 10.79 9.96 8 137119 341 56154599
Vocal cord thickening 10.77 9.96 4 137123 38 56154902
Middle insomnia 10.76 9.96 54 137073 10896 56144044
Acute myocardial infarction 10.70 9.96 38 137089 30355 56124585
Serum sickness-like reaction 10.67 9.96 9 137118 463 56154477
Poor quality sleep 10.67 9.96 77 137050 17678 56137262
Tubulointerstitial nephritis 10.66 9.96 15 137112 16650 56138290
Pulmonary toxicity 10.64 9.96 3 137124 7880 56147060
Abnormal sleep-related event 10.62 9.96 11 137116 735 56154205
Concussion 10.59 9.96 44 137083 8202 56146738
Postmortem blood drug level abnormal 10.58 9.96 8 137119 351 56154589
Poor feeding infant 10.55 9.96 7 137120 249 56154691
Hyperphagia 10.52 9.96 16 137111 1580 56153360
Ankle operation 10.51 9.96 14 137113 1224 56153716
Mouth ulceration 10.47 9.96 37 137090 29603 56125337
Foetal death 10.39 9.96 45 137082 8542 56146398
Gait disturbance 10.39 9.96 492 136635 162829 55992111
Hangover 10.36 9.96 15 137112 1418 56153522
Cystitis interstitial 10.35 9.96 15 137112 1419 56153521
Live birth 10.35 9.96 20 137107 19585 56135355
Haemodialysis 10.31 9.96 4 137123 8587 56146353
Rhinorrhoea 10.31 9.96 89 137038 56948 56097992
Red blood cell count decreased 10.26 9.96 50 137077 36567 56118373
Tearfulness 10.25 9.96 26 137101 3742 56151198
Osteoporosis 10.23 9.96 181 136946 51871 56103069
Haemoptysis 10.18 9.96 32 137095 26528 56128412
Blood pressure diastolic abnormal 10.16 9.96 8 137119 11590 56143350
Eosinophilia 10.16 9.96 21 137106 20056 56134884
Foot operation 10.15 9.96 36 137091 6231 56148709
Heavy menstrual bleeding 10.15 9.96 71 137056 16138 56138802
Accidental poisoning 10.11 9.96 10 137117 633 56154307
Bacteraemia 10.07 9.96 14 137113 15617 56139323
Pineal gland cyst 10.07 9.96 3 137124 13 56154927
Clostridium difficile colitis 10.00 9.96 19 137108 18719 56136221

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 2175.39 11.39 1535 51471 89979 31554359
Depression 1529.10 11.39 1241 51765 89574 31554764
Toxicity to various agents 600.15 11.39 1080 51926 180407 31463931
Drug interaction 536.47 11.39 1116 51890 207427 31436911
Serotonin syndrome 507.08 11.39 342 52664 18431 31625907
Suicidal ideation 361.30 11.39 371 52635 36035 31608303
Intentional overdose 356.22 11.39 391 52615 40998 31603340
Overdose 309.97 11.39 528 52478 84136 31560202
Anxiety 308.93 11.39 549 52457 90484 31553854
Drug abuse 241.40 11.39 484 52522 87274 31557064
Seizure 225.58 11.39 508 52498 99260 31545078
Loss of personal independence in daily activities 200.69 11.39 242 52764 28046 31616292
Cardio-respiratory arrest 188.27 11.39 322 52684 51404 31592934
Psychiatric decompensation 187.92 11.39 83 52923 1893 31642445
Febrile neutropenia 149.97 11.39 15 52991 121834 31522504
Depression suicidal 149.90 11.39 67 52939 1573 31642765
Suicide attempt 143.62 11.39 238 52768 37010 31607328
Electrocardiogram QRS complex prolonged 143.53 11.39 89 52917 4140 31640198
Status epilepticus 137.73 11.39 133 52873 11973 31632365
Generalised tonic-clonic seizure 137.24 11.39 168 52838 19763 31624575
Paranoia 133.55 11.39 123 52883 10432 31633906
Tearfulness 133.54 11.39 65 52941 1862 31642476
Hyperreflexia 131.40 11.39 74 52932 2875 31641463
Anaemia 129.14 11.39 101 52905 213421 31430917
Acute kidney injury 123.50 11.39 173 52833 279541 31364797
Thrombocytopenia 120.66 11.39 44 52962 142703 31501635
Psychotic disorder 106.15 11.39 157 52849 22136 31622202
Tremor 105.58 11.39 324 52682 76096 31568242
Poisoning 104.95 11.39 107 52899 10284 31634054
Suspected suicide 97.10 11.39 69 52937 4038 31640300
Distributive shock 94.19 11.39 43 52963 1062 31643276
Depressive symptom 94.06 11.39 53 52953 2061 31642277
Insomnia 89.21 11.39 354 52652 94482 31549856
Sepsis 87.86 11.39 75 52931 151854 31492484
Pyrexia 87.27 11.39 242 52764 303598 31340740
Agitation 86.60 11.39 242 52764 53927 31590411
Sexual dysfunction 82.28 11.39 73 52933 5895 31638443
Neutropenia 81.51 11.39 69 52937 140295 31504043
Malignant neoplasm progression 76.38 11.39 19 52987 78979 31565359
Product substitution issue 75.68 11.39 86 52920 9346 31634992
Major depression 75.09 11.39 60 52946 4193 31640145
General physical health deterioration 74.55 11.39 49 52957 113386 31530952
Pneumonia 71.24 11.39 304 52702 335008 31309330
Psychomotor skills impaired 70.41 11.39 51 52955 3076 31641262
Pancytopenia 67.10 11.39 31 52975 87285 31557053
Platelet count decreased 66.94 11.39 52 52954 110383 31533955
Postmortem blood drug level increased 66.14 11.39 22 52984 222 31644116
Depressed mood 64.63 11.39 110 52896 17465 31626873
Interstitial lung disease 62.89 11.39 13 52993 61390 31582948
Rhinitis perennial 59.77 11.39 22 52984 306 31644032
Panic attack 59.31 11.39 73 52933 8630 31635708
Therapeutic response unexpected 58.78 11.39 74 52932 8950 31635388
Septic shock 58.24 11.39 19 52987 66139 31578199
Irritability 57.76 11.39 122 52884 22767 31621571
Exposure via ingestion 57.28 11.39 38 52968 1987 31642351
Respiratory arrest 57.27 11.39 132 52874 26125 31618213
Hyperkalaemia 55.74 11.39 19 52987 64332 31580006
Renal impairment 54.45 11.39 39 52967 86310 31558028
Cardiogenic shock 53.75 11.39 117 52889 22291 31622047
Anger 53.73 11.39 79 52927 11074 31633264
Disturbance in attention 53.60 11.39 117 52889 22333 31622005
Tardive dyskinesia 52.09 11.39 55 52951 5504 31638834
Clonus 52.02 11.39 39 52967 2480 31641858
Memory impairment 51.98 11.39 161 52845 37969 31606369
Vein of Galen aneurysmal malformation 51.74 11.39 11 52995 11 31644327
C-reactive protein increased 50.44 11.39 10 52996 48640 31595698
Disease progression 49.44 11.39 47 52959 90417 31553921
Feeling abnormal 48.96 11.39 207 52799 56795 31587543
Cardiac failure 48.94 11.39 43 52963 85910 31558428
Pupil fixed 48.20 11.39 32 52974 1675 31642663
Diarrhoea 48.03 11.39 369 52637 352040 31292298
Erectile dysfunction 47.93 11.39 102 52904 19133 31625205
Dyspnoea 47.10 11.39 359 52647 343120 31301218
Autonomic nervous system imbalance 46.12 11.39 36 52970 2431 31641907
Incorrect route of product administration 45.50 11.39 75 52931 11598 31632740
Electrocardiogram QT prolonged 44.21 11.39 152 52854 37835 31606503
Drug withdrawal syndrome 43.94 11.39 97 52909 18653 31625685
Libido decreased 43.56 11.39 45 52961 4391 31639947
Renal failure 43.42 11.39 88 52918 123242 31521096
Cardiac arrest 43.35 11.39 276 52730 88786 31555552
Haemoglobin decreased 41.74 11.39 78 52928 112597 31531741
Adjustment disorder 41.09 11.39 25 52981 1123 31643215
Sedation 40.98 11.39 95 52911 18870 31625468
Maternal drugs affecting foetus 40.88 11.39 41 52965 3862 31640476
Pleural effusion 40.84 11.39 39 52967 74881 31569457
Myoclonus 40.56 11.39 79 52927 13911 31630427
Product residue present 39.94 11.39 34 52972 2596 31641742
Euphoric mood 39.70 11.39 45 52961 4875 31639463
Hallucination, visual 39.63 11.39 84 52922 15710 31628628
Off label use 39.10 11.39 382 52624 346892 31297446
Multiple organ dysfunction syndrome 38.96 11.39 34 52972 68169 31576169
Depersonalisation/derealisation disorder 38.31 11.39 19 52987 567 31643771
Mucosal inflammation 38.03 11.39 6 53000 34421 31609917
Psychomotor retardation 37.49 11.39 36 52970 3216 31641122
Basilar artery occlusion 36.98 11.39 11 52995 74 31644264
Hyponatraemic coma 36.91 11.39 9 52997 24 31644314
Electrocardiogram PR prolongation 36.74 11.39 20 52986 726 31643612
Intentional product misuse 36.69 11.39 143 52863 37808 31606530
Neonatal toxicity 36.13 11.39 9 52997 27 31644311
Drug reaction with eosinophilia and systemic symptoms 36.10 11.39 4 53002 30014 31614324
Bradyphrenia 35.06 11.39 40 52966 4364 31639974
Dysphoria 34.89 11.39 29 52977 2143 31642195
Blood creatinine increased 34.48 11.39 60 52946 89018 31555320
Lower respiratory tract infection 33.36 11.39 4 53002 28233 31616105
Hypokalaemia 32.72 11.39 25 52981 53549 31590789
Ascites 32.37 11.39 14 52992 40999 31603339
Rheumatoid arthritis 32.27 11.39 20 52986 47789 31596549
Mood swings 32.09 11.39 50 52956 7374 31636964
Substance abuse 32.04 11.39 49 52957 7109 31637229
Mania 31.85 11.39 56 52950 9121 31635217
Mood altered 31.69 11.39 53 52953 8293 31636045
Leukopenia 31.63 11.39 30 52976 57798 31586540
Infection 30.97 11.39 56 52950 81875 31562463
Tinnitus 30.32 11.39 77 52929 16198 31628140
Transposition of the great vessels 30.17 11.39 15 52991 450 31643888
Vasoplegia syndrome 29.88 11.39 24 52982 1689 31642649
Melaena 29.40 11.39 9 52997 32645 31611693
Aggression 29.39 11.39 132 52874 37159 31607179
Restless legs syndrome 29.11 11.39 49 52957 7707 31636631
Intentional self-injury 29.09 11.39 67 52939 13248 31631090
Encephalopathy neonatal 28.73 11.39 8 52998 41 31644297
White blood cell count decreased 28.55 11.39 65 52941 87333 31557005
Cholestasis 28.55 11.39 4 53002 25071 31619267
Talipes 28.31 11.39 24 52982 1822 31642516
Hepatic function abnormal 28.16 11.39 17 52989 41205 31603133
Cytomegalovirus infection 27.99 11.39 4 53002 24703 31619635
Feelings of worthlessness 27.48 11.39 12 52994 266 31644072
Hallucination 27.17 11.39 151 52855 46259 31598079
Delusion 26.91 11.39 61 52945 11936 31632402
Prescribed overdose 26.76 11.39 52 52954 9140 31635198
Drug withdrawal syndrome neonatal 26.60 11.39 31 52975 3461 31640877
Tachycardia 26.55 11.39 218 52788 75989 31568349
Gastrointestinal haemorrhage 26.47 11.39 62 52944 82487 31561851
Feeling jittery 26.25 11.39 32 52974 3745 31640593
Infusion related reaction 26.20 11.39 25 52981 48030 31596308
Crying 26.03 11.39 39 52967 5558 31638780
Eosinophilia 25.80 11.39 4 53002 23249 31621089
Erythema 25.30 11.39 61 52945 80344 31563994
Dry mouth 25.15 11.39 94 52912 24364 31619974
Abnormal behaviour 24.85 11.39 92 52914 23736 31620602
Emotional distress 24.77 11.39 66 52940 14290 31630048
Abdominal pain 24.72 11.39 143 52863 145809 31498529
Bone marrow failure 24.71 11.39 8 52998 28000 31616338
Cerebral haemorrhage 24.65 11.39 12 52994 32800 31611538
Apathy 24.39 11.39 41 52965 6441 31637897
Drug dependence 24.24 11.39 88 52918 22491 31621847
Mental status changes 23.76 11.39 121 52885 35847 31608491
Sleep disorder 23.63 11.39 97 52909 26251 31618087
Malaise 23.53 11.39 175 52831 168336 31476002
Atrial fibrillation 23.52 11.39 104 52902 113679 31530659
Withdrawal syndrome 23.47 11.39 57 52949 11660 31632678
Thinking abnormal 23.34 11.39 37 52969 5536 31638802
Stomatitis 23.33 11.39 19 52987 39419 31604919
Pelvic abscess 23.25 11.39 16 52990 889 31643449
Dehydration 22.77 11.39 112 52894 118999 31525339
Gamma-glutamyltransferase increased 22.76 11.39 9 52997 27816 31616522
Hypomania 22.53 11.39 23 52983 2212 31642126
Hallucination, auditory 22.49 11.39 52 52954 10308 31634030
Oedema peripheral 22.34 11.39 101 52905 109738 31534600
Dissociation 22.08 11.39 18 52988 1294 31643044
Respiratory failure 22.03 11.39 91 52915 101358 31542980
Marital problem 21.85 11.39 7 52999 62 31644276
Jaundice 21.38 11.39 12 52994 30275 31614063
Dyskinesia 21.20 11.39 80 52926 20830 31623508
Decreased interest 21.15 11.39 22 52984 2163 31642175
Akathisia 21.07 11.39 41 52965 7212 31637126
Oxygen saturation decreased 20.95 11.39 31 52975 49084 31595254
Hallucination, tactile 20.95 11.39 10 52996 274 31644064
Orgasm abnormal 20.88 11.39 8 52998 125 31644213
Product complaint 20.87 11.39 35 52971 5489 31638849
Unresponsive to stimuli 20.83 11.39 92 52914 25708 31618630
Weight increased 20.71 11.39 221 52785 82726 31561612
Gun shot wound 20.53 11.39 16 52990 1078 31643260
Substance use disorder 20.39 11.39 12 52994 507 31643831
Road traffic accident 20.33 11.39 67 52939 16314 31628024
Nightmare 20.14 11.39 55 52951 12082 31632256
Amnesia 20.09 11.39 85 52921 23317 31621021
Prostate cancer 19.99 11.39 20 52986 37581 31606757
Persecutory delusion 19.81 11.39 22 52984 2330 31642008
Vomiting 19.76 11.39 260 52746 223713 31420625
Disseminated intravascular coagulation 19.72 11.39 5 53001 20532 31623806
Pre-existing condition improved 19.62 11.39 22 52984 2355 31641983
Dysarthria 19.29 11.39 105 52901 31912 31612426
Ideas of reference 19.27 11.39 6 53000 48 31644290
Liver disorder 19.26 11.39 13 52993 29694 31614644
Haematuria 19.02 11.39 30 52976 46284 31598054
Lupus-like syndrome 18.75 11.39 22 52984 2473 31641865
Atrial septal defect 18.73 11.39 38 52968 6889 31637449
Disorientation 18.64 11.39 101 52905 30643 31613695
Lung disorder 18.58 11.39 16 52990 32296 31612042
Injection site reaction 18.54 11.39 52 52954 11599 31632739
Drug resistance 18.51 11.39 8 52998 23445 31620893
Plasma cell myeloma 18.49 11.39 42 52964 56489 31587849
Obsessive-compulsive disorder 18.28 11.39 31 52975 4906 31639432
Toxic epidermal necrolysis 18.27 11.39 5 53001 19519 31624819
Foetal exposure during pregnancy 18.24 11.39 124 52882 40752 31603586
Clonic convulsion 18.14 11.39 12 52994 624 31643714
Obesity 18.12 11.39 50 52956 11050 31633288
Psychomotor hyperactivity 17.87 11.39 43 52963 8744 31635594
Alcoholism 17.72 11.39 25 52981 3374 31640964
Hepatocellular injury 17.57 11.39 7 52999 21537 31622801
Abulia 17.44 11.39 11 52995 527 31643811
Blood testosterone decreased 17.39 11.39 28 52978 4245 31640093
Agranulocytosis 17.17 11.39 7 52999 21240 31623098
Acute myeloid leukaemia 17.07 11.39 5 53001 18667 31625671
International normalised ratio increased 17.00 11.39 31 52975 45192 31599146
Accidental poisoning 16.63 11.39 12 52994 719 31643619
Mydriasis 16.61 11.39 35 52971 6517 31637821
Cognitive disorder 16.57 11.39 84 52922 24839 31619499
Gastrooesophageal reflux disease 16.47 11.39 105 52901 33766 31610572
Postictal state 16.44 11.39 12 52994 732 31643606
Delirium 16.35 11.39 122 52884 41299 31603039
Dependence 16.32 11.39 14 52992 1080 31643258
Cutaneous lupus erythematosus 16.30 11.39 12 52994 742 31643596
Vision blurred 16.29 11.39 123 52883 41792 31602546
Dissociative disorder 16.22 11.39 8 52998 236 31644102
Poor feeding infant 16.14 11.39 10 52996 464 31643874
Myelodysplastic syndrome 16.12 11.39 6 53000 19245 31625093
Loss of employment 15.88 11.39 10 52996 478 31643860
Product quality issue 15.80 11.39 61 52945 16050 31628288
Decreased appetite 15.74 11.39 172 52834 153045 31491293
Tongue biting 15.73 11.39 12 52994 783 31643555
Hallucinations, mixed 15.54 11.39 20 52986 2472 31641866
Hostility 15.44 11.39 12 52994 805 31643533
Gastric hypomotility 15.31 11.39 6 53000 100 31644238
Treatment failure 15.30 11.39 28 52978 40764 31603574
Upper gastrointestinal haemorrhage 15.23 11.39 10 52996 23173 31621165
Hyperhidrosis 15.19 11.39 176 52830 67217 31577121
Inflammation 15.13 11.39 12 52994 25229 31619109
Energy increased 15.05 11.39 14 52992 1202 31643136
Hypoglycaemia 14.97 11.39 40 52966 50906 31593432
Suicidal behaviour 14.92 11.39 15 52991 1417 31642921
Abnormal clotting factor 14.90 11.39 5 53001 52 31644286
Colitis 14.83 11.39 21 52985 33866 31610472
Hypoplastic right heart syndrome 14.79 11.39 4 53002 18 31644320
Neutrophil count decreased 14.74 11.39 35 52971 46359 31597979
Balance disorder 14.65 11.39 110 52896 37312 31607026
Hunger 14.62 11.39 15 52991 1452 31642886
Loss of libido 14.59 11.39 19 52987 2376 31641962
Hepatic failure 14.58 11.39 20 52986 32682 31611656
Brugada syndrome 14.57 11.39 11 52995 707 31643631
Priapism 14.51 11.39 27 52979 4593 31639745
Injection site mass 14.49 11.39 31 52975 5833 31638505
Rash maculo-papular 14.46 11.39 13 52993 25706 31618632
Persistent depressive disorder 14.39 11.39 8 52998 303 31644035
Pulmonary fibrosis 14.28 11.39 5 53001 16655 31627683
Blood triglycerides increased 14.20 11.39 52 52954 13345 31630993
Lip pruritus 14.11 11.39 3 53003 3 31644335
Binge drinking 14.11 11.39 3 53003 3 31644335
Urine amphetamine positive 13.98 11.39 4 53002 23 31644315
Sleep apnoea syndrome 13.98 11.39 65 52941 18560 31625778
Sinus tachycardia 13.94 11.39 58 52948 15791 31628547
Double inlet left ventricle 13.84 11.39 4 53002 24 31644314
Pulmonary oedema 13.80 11.39 34 52972 44468 31599870
Sleep disorder due to a general medical condition 13.79 11.39 24 52982 3878 31640460
Lactic acidosis 13.77 11.39 20 52986 31917 31612421
Abnormal dreams 13.62 11.39 34 52972 7074 31637264
Product solubility abnormal 13.54 11.39 9 52997 472 31643866
Toxic optic neuropathy 13.54 11.39 11 52995 787 31643551
Tubulointerstitial nephritis 13.54 11.39 7 52999 18489 31625849
Gambling disorder 13.52 11.39 15 52991 1587 31642751
Extra dose administered 13.46 11.39 22 52984 3378 31640960
Ejaculation disorder 13.43 11.39 12 52994 978 31643360
Neuropathy peripheral 13.40 11.39 73 52933 75576 31568762
Migraine 13.35 11.39 53 52953 14127 31630211
Bipolar disorder 13.28 11.39 23 52983 3701 31640637
Mental disorder 13.26 11.39 52 52954 13782 31630556
Depressed level of consciousness 13.20 11.39 110 52896 38491 31605847
Testicular pain 13.19 11.39 19 52987 2613 31641725
Sperm concentration decreased 13.11 11.39 6 53000 149 31644189
Haemoptysis 13.07 11.39 21 52985 32168 31612170
Ventricular hypoplasia 13.06 11.39 5 53001 78 31644260
Epistaxis 13.05 11.39 46 52960 53661 31590677
Blood lactate dehydrogenase increased 13.05 11.39 9 52997 20330 31624008
Pericardial effusion 13.01 11.39 11 52995 22412 31621926
Inadequate analgesia 12.86 11.39 19 52987 2674 31641664
Enuresis 12.80 11.39 17 52989 2167 31642171
Slow speech 12.78 11.39 12 52994 1042 31643296
Muscle rigidity 12.75 11.39 41 52965 9856 31634482
Lymphadenopathy 12.66 11.39 15 52991 26106 31618232
Lethargy 12.63 11.39 109 52897 38532 31605806
Cytokine release syndrome 12.63 11.39 6 53000 16636 31627702
Respiratory distress 12.61 11.39 23 52983 33530 31610808
Pneumonitis 12.44 11.39 20 52986 30632 31613706
Univentricular heart 12.43 11.39 4 53002 36 31644302
Bacteraemia 12.43 11.39 7 52999 17627 31626711
Metastases to liver 12.41 11.39 3 53003 12724 31631614
Muscle twitching 12.38 11.39 36 52970 8194 31636144
Congenital aortic stenosis 12.35 11.39 5 53001 91 31644247
Hypotonia neonatal 12.35 11.39 13 52993 1296 31643042
Restlessness 12.35 11.39 74 52932 23287 31621051
Pulmonary embolism 12.25 11.39 83 52923 81563 31562775
Joint swelling 12.17 11.39 47 52959 53384 31590954
Alanine aminotransferase increased 12.17 11.39 74 52932 74582 31569756
Emotional disorder 12.12 11.39 27 52979 5222 31639116
Urinary tract infection 12.11 11.39 77 52929 76792 31567546
Product use in unapproved indication 11.99 11.39 107 52899 99064 31545274
Hypercholesterolaemia 11.96 11.39 35 52971 7995 31636343
Derealisation 11.95 11.39 9 52997 576 31643762
Symptom masked 11.91 11.39 9 52997 579 31643759
Haemorrhage 11.87 11.39 40 52966 47294 31597044
Change in sustained attention 11.80 11.39 3 53003 10 31644328
Drug eruption 11.74 11.39 8 52998 18179 31626159
Male orgasmic disorder 11.70 11.39 5 53001 105 31644233
Bladder cancer 11.66 11.39 5 53001 14720 31629618
Tongue spasm 11.63 11.39 4 53002 45 31644293
Accidental overdose 11.61 11.39 61 52945 18289 31626049
Congenital tricuspid valve atresia 11.57 11.39 5 53001 108 31644230
Gastric ulcer 11.54 11.39 5 53001 14629 31629709
Hypomagnesaemia 11.50 11.39 9 52997 19049 31625289
Drug screen positive 11.47 11.39 22 52984 3830 31640508

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 5505.01 10.33 4256 147801 222879 70553508
Toxicity to various agents 1381.18 10.33 2725 149332 379447 70396940
Depression 1284.29 10.33 1841 150216 197133 70579254
Intentional overdose 1053.17 10.33 1173 150884 97262 70679125
Overdose 762.04 10.33 1331 150726 168414 70607973
Serotonin syndrome 740.29 10.33 658 151399 41456 70734931
Seizure 633.01 10.33 1263 150794 176699 70599688
Electrocardiogram QRS complex prolonged 616.58 10.33 336 151721 9470 70766917
Anxiety 551.06 10.33 1358 150699 218972 70557415
Generalised tonic-clonic seizure 528.89 10.33 544 151513 41117 70735270
Cardio-respiratory arrest 525.42 10.33 845 151212 99832 70676555
Suicidal ideation 492.46 10.33 674 151383 68922 70707465
Suspected suicide 401.32 10.33 245 151812 8589 70767798
Status epilepticus 373.95 10.33 354 151703 24172 70752215
Suicide attempt 329.93 10.33 603 151454 78907 70697480
Acute kidney injury 274.60 10.33 370 151687 474254 70302133
Anaemia 273.62 10.33 277 151780 403146 70373241
Febrile neutropenia 267.31 10.33 56 152001 204262 70572125
Drug abuse 265.97 10.33 806 151251 146450 70629937
Cardiac arrest 256.68 10.33 840 151217 158994 70617393
Thrombocytopenia 251.38 10.33 99 151958 239011 70537376
Electrocardiogram QT prolonged 249.01 10.33 552 151505 82965 70693422
Agitation 246.26 10.33 588 151469 92787 70683600
Temperature regulation disorder 240.47 10.33 138 151919 4306 70772081
Product substitution issue 238.96 10.33 244 151813 18269 70758118
Poisoning 225.23 10.33 260 151797 22362 70754025
Respiratory arrest 219.85 10.33 406 151651 53527 70722860
Neutropenia 214.53 10.33 144 151913 257012 70519375
Pyrexia 204.97 10.33 645 151412 606307 70170080
Mydriasis 192.50 10.33 204 151853 15949 70760438
Tremor 181.28 10.33 737 151320 154887 70621500
Pancytopenia 173.44 10.33 54 152003 151053 70625334
Coeliac disease 172.41 10.33 148 151909 8885 70767502
Food allergy 167.48 10.33 142 151915 8382 70768005
Drug withdrawal syndrome 153.55 10.33 262 151795 32453 70743934
Sensitisation 150.64 10.33 83 151974 2390 70773997
Irritability 148.58 10.33 282 151775 37943 70738444
Sepsis 147.98 10.33 184 151873 244361 70532026
Polycystic ovaries 146.94 10.33 86 151971 2786 70773601
Drug interaction 144.45 10.33 1348 150709 380093 70396294
Asthma 142.17 10.33 574 151483 120219 70656168
Malignant neoplasm progression 140.60 10.33 43 152014 121696 70654691
Cardiac failure 140.31 10.33 66 151991 143475 70632912
Psychiatric decompensation 138.64 10.33 84 151973 2903 70773484
Exposure via ingestion 135.59 10.33 100 151957 4815 70771572
General physical health deterioration 135.20 10.33 185 151872 235846 70540541
Sinus tachycardia 132.81 10.33 251 151806 33662 70742725
Postmortem blood drug level increased 131.66 10.33 53 152004 730 70775657
Immunodeficiency 128.58 10.33 173 151884 17382 70759005
Platelet count decreased 125.66 10.33 118 151939 178104 70598283
Hyperhidrosis 124.08 10.33 585 151472 131001 70645386
Ejection fraction 123.74 10.33 65 151992 1697 70774690
Myoclonus 119.66 10.33 208 151849 26147 70750240
Renal impairment 118.07 10.33 82 151975 143855 70632532
Hyperkalaemia 117.19 10.33 41 152016 106550 70669837
Dyspnoea 117.12 10.33 1072 150985 768988 70007399
Hyperreflexia 112.61 10.33 107 151950 7335 70769052
Headache 111.42 10.33 1804 150253 578601 70197786
Depression suicidal 110.88 10.33 72 151985 2815 70773572
Disease progression 110.13 10.33 104 151953 156568 70619819
Loss of personal independence in daily activities 110.04 10.33 416 151641 84494 70691893
Foot deformity 107.09 10.33 173 151884 20482 70755905
Atrial fibrillation 107.05 10.33 143 151914 184205 70592182
Paranoia 105.32 10.33 156 151901 17132 70759255
Joint dislocation 104.60 10.33 142 151915 14389 70761998
Tearfulness 103.52 10.33 86 151971 4934 70771453
Lupus-like syndrome 102.48 10.33 125 151932 11390 70764997
Tardive dyskinesia 100.31 10.33 115 151942 9814 70766573
Feeling abnormal 99.87 10.33 583 151474 141736 70634651
Insomnia 94.29 10.33 793 151264 217013 70559374
Anger 91.78 10.33 141 151916 15991 70760396
Multiple organ dysfunction syndrome 91.43 10.33 60 151997 108455 70667932
Pneumonia 90.49 10.33 830 151227 595402 70180985
Diarrhoea 90.31 10.33 1162 150895 782179 69994208
Withdrawal syndrome 89.78 10.33 178 151879 24726 70751661
Sleep apnoea syndrome 87.24 10.33 207 151850 32506 70743881
Migraine 87.13 10.33 346 151711 71892 70704495
Drug hypersensitivity 86.73 10.33 902 151155 261557 70514830
Exostosis 85.32 10.33 128 151929 14217 70762170
Retinitis 85.23 10.33 71 151986 4089 70772298
Peripheral swelling 83.40 10.33 246 151811 236317 70540070
Lower respiratory tract infection 82.56 10.33 71 151986 111842 70664545
Bursitis 82.50 10.33 179 151878 26494 70749893
Panic attack 82.05 10.33 160 151897 21959 70754428
Crying 81.88 10.33 156 151901 21043 70755344
Septic shock 81.87 10.33 72 151985 112186 70664201
Mental status changes 81.62 10.33 309 151748 62792 70713595
Haemoglobin decreased 81.61 10.33 201 151856 204958 70571429
Depressive symptom 81.28 10.33 76 151981 5105 70771282
Tachycardia 81.10 10.33 600 151457 157946 70618441
Pupil fixed 80.60 10.33 63 151994 3311 70773076
Mucosal inflammation 80.09 10.33 23 152034 67827 70708560
Memory impairment 79.50 10.33 401 151656 92240 70684147
Swelling 78.75 10.33 180 151877 188359 70588028
Cardiogenic shock 78.32 10.33 212 151845 36095 70740292
Major depression 77.81 10.33 94 151963 8480 70767907
White blood cell count decreased 73.87 10.33 159 151898 169982 70606405
Hepatic function abnormal 73.29 10.33 27 152030 67969 70708418
Interstitial lung disease 72.95 10.33 70 151987 104615 70671772
Sympathomimetic effect 72.87 10.33 19 152038 52 70776335
Rhinitis allergic 71.76 10.33 94 151963 9201 70767186
Cholestasis 71.75 10.33 9 152048 47863 70728524
Bone marrow failure 71.58 10.33 10 152047 49000 70727387
Postictal state 70.26 10.33 44 152013 1614 70774773
Infarction 69.99 10.33 64 151993 4178 70772209
Hallucination 69.63 10.33 336 151721 75924 70700463
Renal failure 69.27 10.33 193 151864 188877 70587510
Leukopenia 68.88 10.33 76 151981 106484 70669903
Carpal tunnel syndrome 67.71 10.33 127 151930 16930 70759457
Helicobacter infection 67.30 10.33 18 152039 55638 70720749
Gastrointestinal haemorrhage 66.91 10.33 120 151937 137288 70639099
Neutrophil count decreased 66.67 10.33 49 152008 83507 70692880
Disturbance in attention 66.56 10.33 223 151834 42671 70733716
Pleural effusion 66.54 10.33 114 151943 132750 70643637
Cytomegalovirus infection 66.08 10.33 5 152052 39753 70736634
Hepatocellular injury 65.93 10.33 10 152047 46081 70730306
Clonus 65.70 10.33 74 151983 6194 70770193
Emotional distress 65.57 10.33 202 151855 36986 70739401
Therapeutic product effect incomplete 64.92 10.33 460 151597 119422 70656965
Psychotic disorder 64.82 10.33 203 151854 37498 70738889
Arthropathy 64.50 10.33 141 151916 149916 70626471
Bronchial neoplasm 62.46 10.33 27 152030 449 70775938
Hypoglycaemia 62.43 10.33 66 151991 94298 70682089
Intentional product misuse 62.39 10.33 336 151721 79259 70697128
Liver disorder 62.18 10.33 27 152030 61541 70714846
Areflexia 61.58 10.33 65 151992 5057 70771330
Duodenal ulcer perforation 60.93 10.33 17 152040 51095 70725292
Pulseless electrical activity 60.90 10.33 105 151952 13110 70763277
Muscle injury 60.82 10.33 6 152051 38488 70737899
Lung disorder 60.47 10.33 37 152020 69447 70706940
Sexual dysfunction 60.22 10.33 73 151984 6608 70769779
Sleep disorder due to a general medical condition 60.21 10.33 92 151965 10384 70766003
Infusion related reaction 60.20 10.33 219 151838 197315 70579072
Melaena 59.69 10.33 23 152034 56332 70720055
Hyponatraemia 59.69 10.33 162 151895 159925 70616462
Rubber sensitivity 59.18 10.33 38 152019 1457 70774930
Folliculitis 59.17 10.33 10 152047 42560 70733827
Bone erosion 59.03 10.33 112 151945 15061 70761326
Ascites 57.36 10.33 37 152020 67510 70708877
Fibromyalgia 56.67 10.33 228 151829 47646 70728741
Hypokalaemia 56.60 10.33 123 151934 131065 70645322
Neuropathy peripheral 56.40 10.33 117 151940 126779 70649608
Depressed mood 56.18 10.33 214 151843 43606 70732781
Distributive shock 56.12 10.33 43 152014 2194 70774193
Nasal turbinate hypertrophy 56.01 10.33 27 152030 584 70775803
Cerebral haemorrhage 55.39 10.33 23 152034 53841 70722546
Blister 55.31 10.33 81 151976 100445 70675942
Product quality issue 53.88 10.33 166 151891 30395 70745992
Plasma cell myeloma 53.30 10.33 47 152010 73154 70703233
Nicotine dependence 52.79 10.33 29 152028 830 70775557
Psychomotor skills impaired 52.63 10.33 55 152002 4229 70772158
Stomatitis 52.59 10.33 124 151933 128387 70648000
Pneumocystis jirovecii pneumonia 52.30 10.33 3 152054 30079 70746308
Jaundice 52.17 10.33 21 152036 50087 70726300
Cholecystitis chronic 52.00 10.33 81 151976 9295 70767092
Akathisia 51.91 10.33 94 151963 12199 70764188
Cerebral venous thrombosis 51.68 10.33 43 152014 2472 70773915
Gamma-glutamyltransferase increased 51.55 10.33 22 152035 50663 70725724
Incorrect route of product administration 51.54 10.33 149 151908 26343 70750044
Oesophageal spasm 51.19 10.33 47 152010 3084 70773303
Endometrial ablation 50.63 10.33 28 152029 812 70775575
Brugada syndrome 50.63 10.33 31 152026 1092 70775295
International normalised ratio increased 50.61 10.33 59 151998 80667 70695720
Nephrectomy 50.45 10.33 37 152020 1766 70774621
Rhinitis perennial 50.13 10.33 21 152036 322 70776065
Brain injury 49.77 10.33 85 151972 10532 70765855
Unresponsive to stimuli 49.72 10.33 232 151825 51699 70724688
Hostility 49.36 10.33 40 152017 2215 70774172
Joint swelling 48.74 10.33 330 151727 252881 70523506
Epistaxis 48.73 10.33 91 151966 102536 70673851
Multiple sclerosis relapse 48.65 10.33 202 151855 42815 70733572
Mental disorder 48.49 10.33 152 151905 28088 70748299
Gastrooesophageal reflux disease 48.26 10.33 347 151710 90492 70685895
Product residue present 48.24 10.33 47 152010 3323 70773064
Therapeutic response unexpected 48.21 10.33 115 151942 18116 70758271
Persistent genital arousal disorder 48.08 10.33 20 152037 301 70776086
Blood creatinine increased 48.01 10.33 152 151905 142849 70633538
Off label use 47.73 10.33 1221 150836 741839 70034548
Libido increased 47.05 10.33 36 152021 1833 70774554
Hepatic failure 47.00 10.33 33 152024 57592 70718795
Thinking abnormal 46.93 10.33 89 151968 11962 70764425
Libido decreased 46.42 10.33 55 152002 4861 70771526
Gastrointestinal disorder 46.18 10.33 98 151959 105329 70671058
Mania 46.14 10.33 109 151948 17065 70759322
C-reactive protein abnormal 43.85 10.33 14 152043 38565 70737822
Hypothyroidism 43.50 10.33 204 151853 45551 70730836
Product odour abnormal 43.15 10.33 29 152028 1202 70775185
Impaired healing 42.83 10.33 58 151999 74316 70702071
Rash maculo-papular 42.49 10.33 28 152029 50517 70725870
Muscle twitching 41.98 10.33 115 151942 19712 70756675
Autonomic nervous system imbalance 41.73 10.33 49 152008 4290 70772097
Respiratory failure 41.54 10.33 203 151854 168532 70607855
Pneumonitis 41.04 10.33 34 152023 54563 70721824
Vision blurred 40.60 10.33 345 151712 94639 70681748
Toxic epidermal necrolysis 40.50 10.33 17 152040 39540 70736847
Haematuria 40.35 10.33 46 152011 63527 70712860
Tinnitus 40.22 10.33 169 151888 36007 70740380
Agranulocytosis 40.17 10.33 18 152039 40280 70736107
Drug reaction with eosinophilia and systemic symptoms 40.17 10.33 39 152018 57974 70718413
Rash 40.05 10.33 813 151244 509749 70266638
Joint stiffness 39.63 10.33 165 151892 35011 70741376
Blood test abnormal 39.63 10.33 93 151964 14497 70761890
Laryngitis 39.35 10.33 89 151968 13542 70762845
Burning sensation 39.29 10.33 220 151837 52650 70723737
Sedation 39.18 10.33 201 151856 46530 70729857
Drug eruption 38.82 10.33 18 152039 39478 70736909
Upper gastrointestinal haemorrhage 38.54 10.33 16 152041 37461 70738926
Disseminated intravascular coagulation 38.53 10.33 12 152045 33586 70742801
Hepatic cirrhosis 38.50 10.33 149 151908 30582 70745805
Mood altered 38.37 10.33 99 151958 16376 70760011
Sleep-related eating disorder 38.31 10.33 22 152035 687 70775700
Syncope 38.17 10.33 204 151853 165505 70610882
Lactic acidosis 38.16 10.33 50 152007 64974 70711413
Bronchial haemorrhage 37.73 10.33 27 152030 1240 70775147
Product complaint 37.72 10.33 82 151975 12149 70764238
Euphoric mood 37.49 10.33 59 151998 6830 70769557
Treatment failure 37.49 10.33 170 151887 143972 70632415
Asthenia 37.32 10.33 724 151333 456942 70319445
Weight increased 37.29 10.33 728 151329 241603 70534784
Myelodysplastic syndrome 37.23 10.33 9 152048 29776 70746611
Endometriosis 37.02 10.33 40 152017 3196 70773191
Nightmare 36.89 10.33 118 151939 22038 70754349
Osteonecrosis of jaw 36.85 10.33 21 152036 40981 70735406
Oesophageal pain 36.67 10.33 43 152014 3759 70772628
Affective disorder 36.55 10.33 61 151996 7418 70768969
Bipolar disorder 35.78 10.33 61 151996 7547 70768840
Psoriasis 35.68 10.33 345 151712 98088 70678299
Fluid retention 35.34 10.33 245 151812 63140 70713247
Hypomagnesaemia 35.06 10.33 22 152035 40742 70735645
Obsessive-compulsive disorder 34.95 10.33 50 152007 5320 70771067
Hallucination, visual 34.94 10.33 140 151917 29197 70747190
Vertigo 34.85 10.33 242 151815 62401 70713986
Psychomotor retardation 34.79 10.33 51 152006 5547 70770840
Blood lactate dehydrogenase increased 34.53 10.33 16 152041 35111 70741276
Upper respiratory tract infection 34.43 10.33 289 151768 78985 70697402
Bronchopulmonary aspergillosis 33.90 10.33 3 152054 20999 70755388
Acute myeloid leukaemia 33.82 10.33 12 152045 30928 70745459
Intentional self-injury 33.75 10.33 146 151911 31504 70744883
Haematemesis 33.56 10.33 33 152024 48764 70727623
Pruritus 33.48 10.33 530 151527 345030 70431357
Decreased interest 33.32 10.33 39 152018 3402 70772985
Anaphylactic shock 33.20 10.33 14 152043 32476 70743911
Prostate cancer 32.54 10.33 13 152044 31150 70745237
Drug resistance 32.31 10.33 21 152036 38169 70738218
Dissociation 32.26 10.33 38 152019 3338 70773049
Polyneuropathy 32.15 10.33 4 152053 21411 70754976
Obesity 32.08 10.33 128 151929 26643 70749744
Feeling jittery 31.81 10.33 74 151983 11469 70764918
Colitis 31.71 10.33 55 152002 63759 70712628
Substance abuse 31.55 10.33 67 151990 9770 70766617
Restless legs syndrome 31.47 10.33 99 151958 18329 70758058
Posterior reversible encephalopathy syndrome 31.24 10.33 7 152050 24395 70751992
Hallucinations, mixed 31.24 10.33 52 152005 6310 70770077
Cough 31.20 10.33 500 151557 324877 70451510
Haemophagocytic lymphohistiocytosis 31.13 10.33 3 152054 19609 70756778
Hyponatraemic coma 30.98 10.33 9 152048 41 70776346
Hepatitis 30.82 10.33 37 152020 49943 70726444
Haemoptysis 30.77 10.33 39 152018 51413 70724974
Urine amphetamine positive 30.59 10.33 10 152047 72 70776315
Sleep paralysis 30.48 10.33 18 152039 593 70775794
Eosinophilia 30.44 10.33 25 152032 40294 70736093
Hypercalcaemia 30.35 10.33 18 152039 34367 70742020
Vomiting 30.12 10.33 1006 151051 592105 70184282
Dysphemia 29.98 10.33 36 152021 3227 70773160
Impaired work ability 29.97 10.33 90 151967 16250 70760137
Device expulsion 29.64 10.33 110 151947 22136 70754251
Complication of device insertion 29.48 10.33 46 152011 5286 70771101
Heart rate decreased 29.42 10.33 55 152002 61960 70714427
Abnormal dreams 29.25 10.33 68 151989 10535 70765852
Rash erythematous 28.89 10.33 200 151857 51518 70724869
Decreased appetite 28.66 10.33 470 151587 304310 70472077
Reversible cerebral vasoconstriction syndrome 28.65 10.33 32 152025 2653 70773734
Sleep disorder due to general medical condition, insomnia type 28.44 10.33 21 152036 35711 70740676
Metastases to liver 28.35 10.33 10 152047 25868 70750519
Haemorrhage 28.18 10.33 89 151968 83726 70692661
Hallucination, auditory 28.17 10.33 95 151962 18233 70758154
Nasopharyngitis 27.95 10.33 323 151734 221883 70554504
Pericardial effusion 27.87 10.33 29 152028 41747 70734640
Cardiac failure congestive 27.84 10.33 173 151884 135284 70641103
Hepatotoxicity 27.73 10.33 32 152025 43954 70732433
Corneal reflex decreased 27.68 10.33 14 152043 337 70776050
Thrombotic microangiopathy 27.63 10.33 3 152054 17845 70758542
Abnormal behaviour 27.51 10.33 147 151910 34562 70741825
Neoplasm progression 27.34 10.33 34 152023 45194 70731193
Dyspnoea exertional 27.28 10.33 82 151975 78348 70698039
Skin ulcer 27.26 10.33 38 152019 48107 70728280
Disorientation 27.23 10.33 215 151842 57708 70718679
Apathy 27.16 10.33 71 151986 11837 70764550
Tongue biting 26.87 10.33 26 152031 1823 70774564
Sputum purulent 26.84 10.33 22 152035 1238 70775149
Pneumothorax 26.63 10.33 11 152046 25835 70750552
Systemic lupus erythematosus 26.60 10.33 120 151937 101782 70674605
Bradyphrenia 26.58 10.33 63 151994 9883 70766504
Nephropathy toxic 26.52 10.33 4 152053 18510 70757877
Anuria 26.48 10.33 5 152052 19648 70756739
Anti-neutrophil cytoplasmic antibody positive vasculitis 26.48 10.33 34 152023 3263 70773124
Bladder cancer 26.43 10.33 3 152054 17239 70759148
Cerebral infarction 26.35 10.33 32 152025 42977 70733410
Blood pressure systolic increased 26.11 10.33 52 152005 57207 70719180
Amnesia 25.85 10.33 196 151861 51959 70724428
Electroencephalogram abnormal 25.85 10.33 43 152014 5215 70771172
Shock haemorrhagic 25.73 10.33 4 152053 18102 70758285
Pericarditis 25.72 10.33 94 151963 84611 70691776
Multiple sclerosis 25.71 10.33 115 151942 25170 70751217
Tubulointerstitial nephritis 25.60 10.33 20 152037 33056 70743331
Peritonitis 25.58 10.33 12 152045 26147 70750240
Anorgasmia 25.36 10.33 20 152037 1065 70775322
Impulse-control disorder 25.14 10.33 24 152033 1655 70774732
Basilar artery occlusion 24.91 10.33 11 152046 193 70776194
Uterine perforation 24.81 10.33 45 152012 5846 70770541
Nervousness 24.80 10.33 132 151925 30988 70745399
Economic problem 24.79 10.33 27 152030 2177 70774210
Pemphigus 24.66 10.33 93 151964 82943 70693444
Arthralgia 24.56 10.33 858 151199 502532 70273855
Blood bilirubin increased 24.33 10.33 58 151999 59843 70716544
Dizziness 24.29 10.33 1222 150835 462919 70313468
Device related infection 24.24 10.33 20 152037 32165 70744222
Erythema dyschromicum perstans 24.07 10.33 8 152049 61 70776326
Mucosal dryness 24.02 10.33 32 152025 3184 70773203
Dehydration 23.89 10.33 341 151716 225801 70550586
Injection site mass 23.85 10.33 90 151967 18253 70758134
Muscle rigidity 23.83 10.33 91 151966 18559 70757828
Haematoma 23.81 10.33 42 152015 48376 70728011
Angina pectoris 23.77 10.33 42 152015 48341 70728046
Transplant rejection 23.69 10.33 5 152052 18166 70758221
Hand deformity 23.69 10.33 100 151957 86382 70690005
Dyskinesia 23.63 10.33 160 151897 40914 70735473
Oedema 23.57 10.33 128 151929 103453 70672934
Drug specific antibody 23.47 10.33 27 152030 2312 70774075
Pancreatitis acute 23.37 10.33 38 152019 45186 70731201
Bronchial disorder 23.33 10.33 27 152030 2327 70774060
Solar urticaria 23.31 10.33 8 152049 68 70776319
Pulmonary oedema 23.25 10.33 94 151963 82184 70694203
Cytokine release syndrome 23.15 10.33 14 152043 26453 70749934
Aspergillus infection 23.13 10.33 5 152052 17863 70758524
Orgasm abnormal 23.04 10.33 10 152047 168 70776219
Anhedonia 23.03 10.33 75 151982 14138 70762249
Feelings of worthlessness 23.02 10.33 14 152043 487 70775900
Psychomotor hyperactivity 22.85 10.33 79 151978 15354 70761033
Pulmonary arterial hypertension 22.84 10.33 22 152035 32833 70743554
Soft tissue injury 22.77 10.33 23 152034 1699 70774688
Attention deficit hyperactivity disorder 22.74 10.33 30 152027 2957 70773430
Alcoholism 22.72 10.33 37 152020 4408 70771979
Metastases to lung 22.63 10.33 4 152053 16480 70759907
Device dislocation 22.61 10.33 102 151955 22405 70753982
Drug screen positive 22.58 10.33 43 152014 5797 70770590
Pallor 22.54 10.33 33 152024 40941 70735446
Drug dependence 22.44 10.33 147 151910 37174 70739213
Brain death 22.38 10.33 40 152017 5138 70771249
Oedema peripheral 22.35 10.33 349 151708 227742 70548645
Bacteraemia 22.34 10.33 18 152039 29291 70747096
Ejection fraction abnormal 22.32 10.33 23 152034 1740 70774647
Urinary tract infection 22.28 10.33 387 151670 248382 70528005
C-reactive protein increased 22.26 10.33 142 151915 110375 70666012
Gambling disorder 22.25 10.33 24 152033 1914 70774473
Drug tolerance 22.00 10.33 49 152008 7379 70769008
Hepatic encephalopathy 21.86 10.33 10 152047 22108 70754279
Irritable bowel syndrome 21.65 10.33 48 152009 50802 70725585
Central nervous system necrosis 21.44 10.33 11 152046 273 70776114
Self esteem decreased 21.38 10.33 17 152040 916 70775471
Rectal haemorrhage 21.37 10.33 71 151986 65760 70710627
Palmar-plantar erythrodysaesthesia syndrome 21.33 10.33 20 152037 30227 70746160
Herpes zoster 21.28 10.33 102 151955 85133 70691254
Dystonia 21.08 10.33 91 151966 19615 70756772
Accidental exposure to product by child 21.08 10.33 28 152029 2778 70773609
Dysphoria 21.07 10.33 36 152021 4462 70771925
Blood pressure fluctuation 21.03 10.33 61 151996 58951 70717436
Mood swings 20.77 10.33 86 151971 18200 70758187
Feeling of despair 20.76 10.33 27 152030 2624 70773763
Basal cell carcinoma 20.72 10.33 25 152032 33673 70742714
Infusion site scar 20.71 10.33 11 152046 294 70776093
Clostridium difficile colitis 20.65 10.33 19 152038 28977 70747410
Infection 20.48 10.33 323 151734 210462 70565925
Accidental poisoning 20.37 10.33 21 152036 1589 70774798
Cardiotoxicity 20.32 10.33 61 151996 11009 70765378
Hypomania 20.22 10.33 42 152015 6030 70770357
Post-traumatic neck syndrome 20.18 10.33 23 152034 1950 70774437
Prescribed overdose 20.12 10.33 113 151944 27068 70749319
Tenosynovitis 20.06 10.33 3 152054 13973 70762414
Oliguria 19.92 10.33 4 152053 15047 70761340
Graft versus host disease 19.87 10.33 4 152053 15019 70761368
Liver injury 19.81 10.33 36 152021 40999 70735388
Liver function test abnormal 19.81 10.33 66 151991 61080 70715307
Balance disorder 19.80 10.33 287 151770 89841 70686546
Treatment noncompliance 19.80 10.33 169 151888 46405 70729982
Hyperbilirubinaemia 19.66 10.33 12 152045 22556 70753831
Left ventricular dysfunction 19.57 10.33 7 152050 17950 70758437
Adrenergic syndrome 19.50 10.33 8 152049 116 70776271
Hyperglycaemia 19.48 10.33 72 151985 64600 70711787
Alanine aminotransferase increased 19.47 10.33 212 151845 147268 70629119
Compulsive shopping 19.45 10.33 15 152042 773 70775614
Stress 19.37 10.33 227 151830 67739 70708648
Metastases to bone 19.35 10.33 12 152045 22364 70754023
Gallbladder disorder 19.11 10.33 82 151975 17630 70758757
Urine sodium increased 19.04 10.33 9 152048 186 70776201
Enterococcal infection 19.04 10.33 4 152053 14578 70761809
Maternal exposure during pregnancy 18.99 10.33 157 151900 115188 70661199
Serum sickness-like reaction 18.92 10.33 13 152044 559 70775828
Acute myocardial infarction 18.92 10.33 86 151971 72801 70703586
Cardiomyopathy acute 18.83 10.33 10 152047 267 70776120
Electrocardiogram PR prolongation 18.68 10.33 19 152038 1415 70774972
Sudden death 18.63 10.33 11 152046 21053 70755334
Delusion 18.62 10.33 86 151971 19079 70757308
Sternal fracture 18.50 10.33 24 152033 2327 70774060
Malaise 18.41 10.33 750 151307 432182 70344205
Haemoglobin urine 18.40 10.33 8 152049 135 70776252
Respiratory distress 18.39 10.33 58 151999 54592 70721795
Renal disorder 18.37 10.33 142 151915 37867 70738520
Binge eating 18.35 10.33 12 152045 475 70775912
Extra dose administered 18.28 10.33 45 152012 7232 70769155
Lymphopenia 18.24 10.33 19 152038 27340 70749047
Blood pressure decreased 18.22 10.33 118 151939 91397 70684990
Atrioventricular block complete 18.15 10.33 5 152052 15158 70761229
Rhonchi 18.11 10.33 30 152027 3625 70772762
Oxygen saturation decreased 18.04 10.33 161 151896 116268 70660119
Erectile dysfunction 18.01 10.33 67 151990 13495 70762892
Product dose omission issue 17.90 10.33 601 151456 216867 70559520
Marital problem 17.86 10.33 9 152048 215 70776172
Ankle arthroplasty 17.80 10.33 17 152040 1173 70775214
Somnolence 17.78 10.33 596 151461 215010 70561377
Sensitivity to weather change 17.76 10.33 45 152012 7360 70769027
Dermatitis bullous 17.72 10.33 3 152054 12754 70763633
Partner stress 17.54 10.33 10 152047 308 70776079
Poor personal hygiene 17.46 10.33 12 152045 516 70775871
Restlessness 17.46 10.33 152 151905 41976 70734411
Homicidal ideation 17.45 10.33 28 152029 3295 70773092
Chronic fatigue syndrome 17.41 10.33 17 152040 1205 70775182
Pulmonary hypertension 17.40 10.33 47 152010 46489 70729898
Loss of libido 17.36 10.33 24 152033 2473 70773914
Dependence 17.35 10.33 23 152034 2277 70774110
Large intestine anastomosis 17.35 10.33 7 152050 97 70776290
Adjustment disorder 17.21 10.33 27 152030 3117 70773270
Cardiac failure acute 17.14 10.33 8 152049 17479 70758908
Hypertensive crisis 17.12 10.33 10 152047 19252 70757135
Brain stem syndrome 17.06 10.33 14 152043 789 70775598
Clostridium difficile infection 17.06 10.33 36 152021 38780 70737607
Liver function test increased 16.97 10.33 29 152028 33818 70742569
Mass excision 16.95 10.33 10 152047 329 70776058
Abdominal pain 16.92 10.33 582 151475 341545 70434842
Lymphoma 16.90 10.33 6 152051 15456 70760931
Staphylococcal sepsis 16.89 10.33 4 152053 13423 70762964
Body temperature decreased 16.87 10.33 22 152035 28650 70747737
Dyspareunia 16.79 10.33 20 152037 1777 70774610
Subacute cutaneous lupus erythematosus 16.77 10.33 27 152030 3186 70773201
Automatism 16.77 10.33 8 152049 169 70776218
Inadequate analgesia 16.75 10.33 31 152026 4091 70772296
Supraventricular tachycardia 16.67 10.33 85 151972 19625 70756762
Generalised anxiety disorder 16.61 10.33 21 152036 1984 70774403
Biliary dyskinesia 16.60 10.33 23 152034 2376 70774011
Duodenal ulcer 16.58 10.33 6 152051 15274 70761113
Gun shot wound 16.47 10.33 16 152041 1127 70775260
Emotional disorder 16.46 10.33 64 151993 13162 70763225
Bruxism 16.36 10.33 29 152028 3700 70772687
Device placement issue 16.35 10.33 14 152043 837 70775550
Injection site reaction 16.26 10.33 171 151886 49681 70726706
Hypocalcaemia 16.25 10.33 46 152011 44813 70731574
Musculoskeletal pain 16.24 10.33 120 151937 90207 70686180
Enterocolitis 16.23 10.33 4 152053 13062 70763325
Job dissatisfaction 16.20 10.33 6 152051 65 70776322
Oscillopsia 16.19 10.33 8 152049 183 70776204
Gastric ulcer 16.16 10.33 27 152030 31763 70744624
Compartment syndrome 16.09 10.33 32 152025 4454 70771933
Choreoathetosis 16.06 10.33 18 152039 1498 70774889
Injury 16.05 10.33 212 151845 65033 70711354
Eczema 15.99 10.33 30 152027 33751 70742636
Haemolytic anaemia 15.97 10.33 8 152049 16786 70759601
Urine osmolarity increased 15.91 10.33 9 152048 273 70776114
Bezoar 15.79 10.33 22 152035 2284 70774103
Haematochezia 15.71 10.33 92 151965 72989 70703398
Clonic convulsion 15.58 10.33 16 152041 1205 70775182
Wound infection fungal 15.58 10.33 8 152049 199 70776188
Impulsive behaviour 15.56 10.33 24 152033 2730 70773657
Tachyphrenia 15.48 10.33 20 152037 1931 70774456
Corneal light reflex test abnormal 15.44 10.33 3 152054 0 70776387
Thalamic infarction 15.38 10.33 16 152041 1224 70775163
Poor quality sleep 15.33 10.33 85 151972 20264 70756123
Pseudomonas infection 15.33 10.33 11 152046 18983 70757404
Postmortem blood drug level abnormal 15.25 10.33 12 152045 637 70775750
Premature delivery 15.12 10.33 14 152043 21290 70755097
Wound 15.08 10.33 137 151920 98595 70677792
Oculocephalogyric reflex absent 15.06 10.33 5 152052 38 70776349
Synovitis 15.03 10.33 191 151866 129037 70647350
Suicidal behaviour 15.03 10.33 25 152032 3031 70773356
Respiratory tract infection 14.98 10.33 44 152013 42354 70734033
Blood pressure diastolic decreased 14.94 10.33 20 152037 25760 70750627
Dry mouth 14.94 10.33 223 151834 70234 70706153
Hypoxia 14.93 10.33 128 151929 93216 70683171
Decorticate posture 14.93 10.33 9 152048 308 70776079
Bronchiectasis 14.82 10.33 8 152049 16089 70760298
Cannabinoid hyperemesis syndrome 14.73 10.33 5 152052 41 70776346
Acute respiratory failure 14.73 10.33 62 151995 53603 70722784
Accidental overdose 14.70 10.33 127 151930 34994 70741393
Orthostatic hypotension 14.69 10.33 59 151998 51684 70724703
Lymphoedema 14.69 10.33 55 152002 11114 70765273
Infusion site discomfort 14.57 10.33 14 152043 973 70775414
Acute hepatic failure 14.54 10.33 23 152034 27649 70748738
Injection site induration 14.52 10.33 48 152009 9120 70767267
Hypoaesthesia 14.51 10.33 432 151625 153307 70623080
Coagulopathy 14.47 10.33 31 152026 33218 70743169
Electrolyte imbalance 14.42 10.33 22 152035 26839 70749548
Body height decreased 14.40 10.33 43 152014 7740 70768647
Priapism 14.36 10.33 29 152028 4081 70772306
Bipolar I disorder 14.20 10.33 19 152038 1898 70774489
Hyperthermia 14.17 10.33 72 151985 16599 70759788
Anticholinergic syndrome 14.16 10.33 24 152033 2956 70773431
Drug titration error 14.15 10.33 14 152043 1009 70775378
Post-traumatic stress disorder 14.11 10.33 30 152027 4377 70772010
Blood potassium increased 14.08 10.33 23 152034 27303 70749084
Ischaemic stroke 14.04 10.33 28 152029 30792 70745595
Vaginal haemorrhage 14.01 10.33 83 151974 20269 70756118
Stoma site ulcer 13.93 10.33 8 152049 250 70776137
Hypophosphataemia 13.78 10.33 9 152048 16317 70760070
Ear infection 13.77 10.33 106 151951 28230 70748157
Muscular weakness 13.76 10.33 211 151846 138125 70638262
Pre-existing condition improved 13.71 10.33 32 152025 4970 70771417
Persecutory delusion 13.61 10.33 30 152027 4487 70771900
Arthritis 13.61 10.33 290 151767 97690 70678697
Ankle fracture 13.56 10.33 67 151990 15277 70761110
Social anxiety disorder 13.49 10.33 10 152047 485 70775902
Hypervolaemia 13.46 10.33 42 152015 39664 70736723
Faeces discoloured 13.41 10.33 23 152034 26786 70749601
Carbon monoxide poisoning 13.40 10.33 8 152049 269 70776118
Abortion spontaneous 13.40 10.33 100 151957 26379 70750008
Non-alcoholic steatohepatitis 13.38 10.33 19 152038 2008 70774379
Pituitary hyperplasia 13.37 10.33 3 152054 3 70776384
Pharyngeal exudate 13.37 10.33 3 152054 3 70776384
Sedation complication 13.35 10.33 6 152051 13404 70762983
Abulia 13.31 10.33 13 152044 922 70775465
Hypotonic urinary bladder 13.27 10.33 5 152052 57 70776330
Homeless 13.15 10.33 6 152051 114 70776273
Illusion 13.15 10.33 17 152040 1642 70774745
Hyperammonaemia 13.08 10.33 3 152054 10290 70766097
Cardiac failure chronic 13.04 10.33 3 152054 10266 70766121
Aggression 13.01 10.33 160 151897 48286 70728101
Erythema induratum 12.91 10.33 7 152050 195 70776192
Hallucination, tactile 12.90 10.33 10 152047 519 70775868
Substance use disorder 12.89 10.33 11 152046 655 70775732
Pelvic pain 12.84 10.33 54 152003 11506 70764881
Face oedema 12.82 10.33 22 152035 25617 70750770
Road traffic accident 12.78 10.33 122 151935 34560 70741827
Initial insomnia 12.77 10.33 36 152021 6273 70770114
Cytopenia 12.76 10.33 11 152046 17312 70759075
Peripheral sensory neuropathy 12.73 10.33 5 152052 12105 70764282
Food craving 12.71 10.33 16 152041 1505 70774882
Red blood cell count decreased 12.68 10.33 63 151994 52098 70724289
Flat affect 12.65 10.33 18 152039 1905 70774482
Pupillary reflex impaired 12.63 10.33 24 152033 3230 70773157
Lower gastrointestinal haemorrhage 12.58 10.33 8 152049 14712 70761675
Cardiac disorder 12.58 10.33 188 151869 59227 70717160
Personality disorder 12.57 10.33 33 152024 5515 70770872
Purpura 12.54 10.33 12 152045 17963 70758424
Blood pressure systolic abnormal 12.50 10.33 6 152051 12903 70763484
Pancreatic carcinoma 12.50 10.33 6 152051 12898 70763489
Dermatillomania 12.47 10.33 7 152050 209 70776178
Blood calcium decreased 12.47 10.33 27 152030 28819 70747568
Kidney transplant rejection 12.47 10.33 3 152054 9958 70766429
Heavy menstrual bleeding 12.43 10.33 57 152000 12608 70763779
Hyperuricaemia 12.43 10.33 4 152053 10962 70765425
Renal tubular necrosis 12.42 10.33 19 152038 23152 70753235
Abscess sterile 12.41 10.33 5 152052 69 70776318
Femur fracture 12.40 10.33 38 152019 36094 70740293
Gastrointestinal sounds abnormal 12.40 10.33 31 152026 5030 70771357
Ventricular tachycardia 12.38 10.33 126 151931 36297 70740090
Glossodynia 12.36 10.33 122 151935 86365 70690022
Anaphylactic reaction 12.36 10.33 102 151955 74872 70701515
Cutaneous lupus erythematosus 12.31 10.33 22 152035 2826 70773561
Blood lactic acid increased 12.26 10.33 52 152005 11121 70765266
Anti-cyclic citrullinated peptide antibody positive 12.25 10.33 94 151963 70091 70706296
Drug tolerance decreased 12.23 10.33 3 152054 9830 70766557
Drug screen false positive 12.22 10.33 13 152044 1020 70775367
Panic disorder 12.22 10.33 22 152035 2842 70773545
Forced expiratory volume decreased 12.22 10.33 39 152018 7275 70769112
Subdural haematoma 12.19 10.33 28 152029 29270 70747117
Binge drinking 12.16 10.33 3 152054 6 70776381
Narcolepsy 12.15 10.33 14 152043 1201 70775186
Encephalitis 12.15 10.33 7 152050 13578 70762809
Persistent depressive disorder 12.14 10.33 13 152044 1028 70775359
Vaginal odour 12.13 10.33 8 152049 321 70776066
Concussion 12.12 10.33 43 152014 8466 70767921
Abscess 11.99 10.33 16 152041 20638 70755749
Dysarthria 11.98 10.33 194 151863 62119 70714268
Ileus 11.94 10.33 21 152036 24216 70752171
Vasoplegia syndrome 11.91 10.33 23 152034 3133 70773254
Klebsiella infection 11.90 10.33 8 152049 14284 70762103
Pain in jaw 11.89 10.33 49 152008 42620 70733767
Rheumatoid nodule 11.80 10.33 9 152048 15058 70761329
Injection site abscess 11.75 10.33 15 152042 1431 70774956
Oesophagitis 11.74 10.33 19 152038 22633 70753754
Gastric haemorrhage 11.73 10.33 8 152049 14177 70762210
Cerebrovascular accident 11.64 10.33 227 151830 143243 70633144
Visual impairment 11.62 10.33 239 151818 80011 70696376
Rhinorrhoea 11.54 10.33 89 151968 66282 70710105
Parkinsonism 11.53 10.33 64 151993 15261 70761126
Cortisol increased 11.53 10.33 9 152048 472 70775915
Right ventricular systolic pressure decreased 11.52 10.33 5 152052 84 70776303
Ideas of reference 11.48 10.33 6 152051 155 70776232
Chills 11.47 10.33 230 151827 144556 70631831
Tongue spasm 11.47 10.33 5 152052 85 70776302
Ejaculation failure 11.44 10.33 8 152049 354 70776033
Increased appetite 11.35 10.33 49 152008 10564 70765823
Rales 11.31 10.33 12 152045 17123 70759264
Partial seizures 11.29 10.33 41 152016 8164 70768223
Bankruptcy 11.27 10.33 4 152053 38 70776349
Right ventricular failure 11.24 10.33 19 152038 22255 70754132
Osteoporosis 11.24 10.33 157 151900 48750 70727637
Hyperthyroidism 11.23 10.33 16 152041 20075 70756312
Blood pressure diastolic abnormal 11.23 10.33 10 152047 15494 70760893
Tri-iodothyronine free decreased 11.22 10.33 8 152049 365 70776022
Inflammatory marker increased 11.21 10.33 3 152054 9271 70767116
Contusion 11.19 10.33 200 151857 127836 70648551
Pulmonary fibrosis 11.14 10.33 37 152020 34273 70742114
Urinary incontinence 11.05 10.33 127 151930 37715 70738672
Derealisation 11.04 10.33 15 152042 1521 70774866
Mental impairment 11.01 10.33 69 151988 17186 70759201
Visuospatial deficit 11.00 10.33 4 152053 41 70776346
Petechiae 10.98 10.33 15 152042 19157 70757230
Staphylococcal bacteraemia 10.97 10.33 5 152052 11077 70765310
Blood uric acid increased 10.95 10.33 3 152054 9126 70767261
Hyperlipidaemia 10.90 10.33 88 151969 23775 70752612
Gastritis erosive 10.89 10.33 4 152053 10091 70766296
Energy increased 10.86 10.33 21 152036 2863 70773524
Blood urea increased 10.85 10.33 56 152001 45853 70730534
Reactive psychosis 10.84 10.33 3 152054 11 70776376
Secondary immunodeficiency 10.84 10.33 21 152036 2868 70773519
Galactorrhoea 10.82 10.33 23 152034 3355 70773032
Family stress 10.82 10.33 10 152047 662 70775725
Angioedema 10.81 10.33 91 151966 66519 70709868
Hypertension 10.80 10.33 755 151302 295278 70481109
Heparin-induced thrombocytopenia 10.78 10.33 3 152054 9034 70767353
Blood parathyroid hormone decreased 10.76 10.33 3 152054 9021 70767366
Pulmonary mass 10.74 10.33 25 152032 26008 70750379
Erysipelas 10.59 10.33 4 152053 9920 70766467
Sputum discoloured 10.58 10.33 73 151984 18778 70757609
Tooth fracture 10.56 10.33 48 152009 10579 70765808
Cachexia 10.55 10.33 4 152053 9896 70766491
Red blood cell sedimentation rate increased 10.54 10.33 128 151929 38514 70737873
Acute pulmonary oedema 10.52 10.33 8 152049 13404 70762983
Feeling guilty 10.48 10.33 11 152046 850 70775537
Myoglobinuria 10.47 10.33 12 152045 1023 70775364
Change in sustained attention 10.45 10.33 3 152054 13 70776374
Tic 10.42 10.33 20 152037 2713 70773674
Multiple fractures 10.34 10.33 35 152022 6730 70769657

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A08AA62 ALIMENTARY TRACT AND METABOLISM
ANTIOBESITY PREPARATIONS, EXCL. DIET PRODUCTS
ANTIOBESITY PREPARATIONS, EXCL. DIET PRODUCTS
Centrally acting antiobesity products
ATC N06AX12 NERVOUS SYSTEM
PSYCHOANALEPTICS
ANTIDEPRESSANTS
Other antidepressants
FDA MoA N0000000102 Norepinephrine Uptake Inhibitors
FDA MoA N0000000114 Dopamine Uptake Inhibitors
FDA PE N0000009282 Increased Dopamine Activity
FDA PE N0000009456 Increased Norepinephrine Activity
CHEBI has role CHEBI:35469 antidepressants
CHEBI has role CHEBI:35703 Xenobiotic
CHEBI has role CHEBI:78298 environmental contaminants
FDA EPC N0000180855 Aminoketone
MeSH PA D000928 Antidepressive Agents
MeSH PA D018687 Antidepressive Agents, Second-Generation
MeSH PA D002491 Central Nervous System Agents
MeSH PA D065690 Cytochrome P-450 CYP2D6 Inhibitors
MeSH PA D065607 Cytochrome P-450 Enzyme Inhibitors
MeSH PA D015259 Dopamine Agents
MeSH PA D018765 Dopamine Uptake Inhibitors
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D065606 Metabolic Side Effects of Drugs and Substances
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D014179 Neurotransmitter Uptake Inhibitors
MeSH PA D011619 Psychotropic Drugs
MeSH PA D000077444 Smoking Cessation Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Depressive disorder indication 35489007
Nicotine dependence indication 56294008 DOID:0050742
Seasonal affective disorder indication 247803002
Major depressive disorder indication 370143000
Smoking cessation assistance indication 384742004
Obesity indication 414916001 DOID:9970
Bipolar affective disorder, current episode depression off-label use 191627008 DOID:3312
Attention deficit hyperactivity disorder off-label use 406506008
Suicidal thoughts contraindication 6471006
Alcoholism contraindication 7200002
Mood swings contraindication 18963009
Lowered convulsive threshold contraindication 19260006
Cirrhosis of liver contraindication 19943007 DOID:5082
Myocardial infarction contraindication 22298006 DOID:5844
Feeling agitated contraindication 24199005
Hypertensive disorder contraindication 38341003 DOID:10763
Anorexia nervosa contraindication 56882008 DOID:8689
Hepatic failure contraindication 59927004
Psychotic disorder contraindication 69322001
Opioid dependence contraindication 75544000 DOID:2559
Bulimia nervosa contraindication 78004001
Hostile behavior contraindication 79351003
Injury of head contraindication 82271004
Weight loss contraindication 89362005
Kidney disease contraindication 90708001 DOID:557
Secondary malignant neoplasm of cerebrum contraindication 94248000
Neoplasm of central nervous system contraindication 126951006 DOID:3620
Seizure disorder contraindication 128613002
Bipolar affective disorder, current episode manic contraindication 191618007
Disease of liver contraindication 235856003 DOID:409
Diabetic - poor control contraindication 268519009
Alcohol withdrawal-induced convulsion contraindication 308742005
Panic disorder contraindication 371631005 DOID:594
Sedative Drug Dependence contraindication
Seizure due to Abrupt Benzodiazepine Withdrawal contraindication
Stimulant Drug Dependence contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.87 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
90MG;8MG CONTRAVE NALPROPION N200063 Sept. 10, 2014 RX TABLET, EXTENDED RELEASE ORAL 11278544 April 21, 2024 FOR CHRONIC WEIGHT MANAGEMENT FOR TREATING OVERWEIGHT OR OBESITY
90MG;8MG CONTRAVE NALPROPION N200063 Sept. 10, 2014 RX TABLET, EXTENDED RELEASE ORAL 7462626 July 20, 2024 FOR CHRONIC WEIGHT MANAGEMENT FOR TREATING OVERWEIGHT OR OBESITY
90MG;8MG CONTRAVE NALPROPION N200063 Sept. 10, 2014 RX TABLET, EXTENDED RELEASE ORAL 8815889 July 20, 2024 FOR EFFECT ON BLOOD GLUCOSE PARAMETERS IN PATIENTS WITH INSULIN RESISTANCE
174MG APLENZIN BAUSCH N022108 April 23, 2008 RX TABLET, EXTENDED RELEASE ORAL 7569610 June 27, 2026 TREATMENT OF MAJOR DEPRESSIVE DISORDER BY DOSING AT INTERVALS OF 24 HOURS
348MG APLENZIN BAUSCH N022108 April 23, 2008 RX TABLET, EXTENDED RELEASE ORAL 7569610 June 27, 2026 TREATMENT OF MAJOR DEPRESSIVE DISORDER BY DOSING AT INTERVALS OF 24 HOURS
522MG APLENZIN BAUSCH N022108 April 23, 2008 RX TABLET, EXTENDED RELEASE ORAL 7569610 June 27, 2026 TREATMENT OF MAJOR DEPRESSIVE DISORDER BY DOSING AT INTERVALS OF 24 HOURS
90MG;8MG CONTRAVE NALPROPION N200063 Sept. 10, 2014 RX TABLET, EXTENDED RELEASE ORAL 9107837 June 4, 2027 USE OF NALTREXONE AND BUPROPION IN EXTENDED-RELEASE FORM FOR CHRONIC WEIGHT MANAGEMENT FOR TREATING OVERWEIGHT OR OBESITY
90MG;8MG CONTRAVE NALPROPION N200063 Sept. 10, 2014 RX TABLET, EXTENDED RELEASE ORAL 10307376 Nov. 8, 2027 USE OF NALTREXONE AND BUPROPION BASED ON AN ESCALATING DOSE SCHEDULE
90MG;8MG CONTRAVE NALPROPION N200063 Sept. 10, 2014 RX TABLET, EXTENDED RELEASE ORAL 8318788 Nov. 8, 2027 USE OF NALTREXONE AND BUPROPION IN A LAYERED FORMULATION FOR CHRONIC WEIGHT MANAGEMENT FOR AFFECTING WEIGHT LOSS
90MG;8MG CONTRAVE NALPROPION N200063 Sept. 10, 2014 RX TABLET, EXTENDED RELEASE ORAL 8722085 Nov. 8, 2027 USE OF NALTREXONE AND BUPROPION BASED ON AN ESCALATING DOSE SCHEDULE
90MG;8MG CONTRAVE NALPROPION N200063 Sept. 10, 2014 RX TABLET, EXTENDED RELEASE ORAL 9125868 Nov. 8, 2027 USE OF NALTREXONE AND BUPROPION BASED ON AN ESCALATING DOSE SCHEDULE
90MG;8MG CONTRAVE NALPROPION N200063 Sept. 10, 2014 RX TABLET, EXTENDED RELEASE ORAL 11324741 May 29, 2029 FOR CHRONIC WEIGHT MANAGEMENT FOR TREATING OVERWEIGHT OR OBESITY
90MG;8MG CONTRAVE NALPROPION N200063 Sept. 10, 2014 RX TABLET, EXTENDED RELEASE ORAL 8916195 Feb. 2, 2030 USE OF NALTREXONE AND BUPROPION IN EXTENDED-RELEASE FORM FOR CHRONIC WEIGHT MANAGEMENT FOR TREATING OVERWEIGHT OR OBESITY
90MG;8MG CONTRAVE NALPROPION N200063 Sept. 10, 2014 RX TABLET, EXTENDED RELEASE ORAL 11033543 Jan. 10, 2031 FOR CHRONIC WEIGHT MANAGEMENT FOR TREATING OVERWEIGHT OR OBESITY
90MG;8MG CONTRAVE NALPROPION N200063 Sept. 10, 2014 RX TABLET, EXTENDED RELEASE ORAL 9248123 Jan. 13, 2032 USE OF NALTREXONE AND BUPROPION FOR CHRONIC WEIGHT MANAGEMENT FOR TREATING OVERWEIGHT OR OBESITY IN PATIENTS WITH MAJOR DEPRESSIVE DISORDER
90MG;8MG CONTRAVE NALPROPION N200063 Sept. 10, 2014 RX TABLET, EXTENDED RELEASE ORAL 10403170 June 5, 2033 FOR CHRONIC WEIGHT MANAGEMENT FOR TREATING OVERWEIGHT OR OBESITY
90MG;8MG CONTRAVE NALPROPION N200063 Sept. 10, 2014 RX TABLET, EXTENDED RELEASE ORAL 11139056 June 5, 2033 FOR CHRONIC WEIGHT MANAGEMENT FOR TREATING OVERWEIGHT OR OBESITY
90MG;8MG CONTRAVE NALPROPION N200063 Sept. 10, 2014 RX TABLET, EXTENDED RELEASE ORAL 9633575 June 25, 2033 FOR CHRONIC WEIGHT MANAGEMENT FOR TREATING OVERWEIGHT OR OBESITY
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 8569328 Oct. 29, 2033 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER
90MG;8MG CONTRAVE NALPROPION N200063 Sept. 10, 2014 RX TABLET, EXTENDED RELEASE ORAL 10231964 July 2, 2034 FOR CHRONIC WEIGHT MANAGEMENT FOR TREATING OVERWEIGHT OR OBESITY
90MG;8MG CONTRAVE NALPROPION N200063 Sept. 10, 2014 RX TABLET, EXTENDED RELEASE ORAL 10828294 July 2, 2034 FOR CHRONIC WEIGHT MANAGEMENT FOR TREATING OVERWEIGHT OR OBESITY
90MG;8MG CONTRAVE NALPROPION N200063 Sept. 10, 2014 RX TABLET, EXTENDED RELEASE ORAL 10835527 July 2, 2034 FOR CHRONIC WEIGHT MANAGEMENT FOR TREATING OVERWEIGHT OR OBESITY
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 10058518 Nov. 5, 2034 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 10064857 Nov. 5, 2034 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 10080727 Nov. 5, 2034 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 10092560 Nov. 5, 2034 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 10092561 Nov. 5, 2034 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 10105327 Nov. 5, 2034 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 10105361 Nov. 5, 2034 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 10251879 Nov. 5, 2034 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 10463634 Nov. 5, 2034 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 10512643 Nov. 5, 2034 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 10548857 Nov. 5, 2034 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 10596167 Nov. 5, 2034 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 10772850 Nov. 5, 2034 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 10786469 Nov. 5, 2034 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 10786496 Nov. 5, 2034 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 10799497 Nov. 5, 2034 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 10806710 Nov. 5, 2034 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 10864209 Nov. 5, 2034 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 10874663 Nov. 5, 2034 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 10874664 Nov. 5, 2034 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 10874665 Nov. 5, 2034 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 10881624 Nov. 5, 2034 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 10881657 Nov. 5, 2034 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 10894046 Nov. 5, 2034 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 10894047 Nov. 5, 2034 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 10898453 Nov. 5, 2034 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 10933034 Nov. 5, 2034 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 10945973 Nov. 5, 2034 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 10966941 Nov. 5, 2034 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 10966974 Nov. 5, 2034 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 11020389 Nov. 5, 2034 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 11058648 Nov. 5, 2034 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 11090300 Nov. 5, 2034 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 11096937 Nov. 5, 2034 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 11123343 Nov. 5, 2034 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 11129826 Nov. 5, 2034 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 11141388 Nov. 5, 2034 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 11141416 Nov. 5, 2034 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 11147808 Nov. 5, 2034 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 11185515 Nov. 5, 2034 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 11191739 Nov. 5, 2034 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 11197839 Nov. 5, 2034 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 11207281 Nov. 5, 2034 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 11213521 Nov. 5, 2034 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 11229640 Nov. 5, 2034 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 11234946 Nov. 5, 2034 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 11253491 Nov. 5, 2034 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 11253492 Nov. 5, 2034 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 11273133 Nov. 5, 2034 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 11273134 Nov. 5, 2034 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 11285118 Nov. 5, 2034 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 11285146 Nov. 5, 2034 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 11291638 Nov. 5, 2034 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 11291665 Nov. 5, 2034 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 11298351 Nov. 5, 2034 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 11298352 Nov. 5, 2034 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 11311534 Nov. 5, 2034 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 11344544 Nov. 5, 2034 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 11357744 Nov. 5, 2034 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 11364233 Nov. 5, 2034 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 11382874 Nov. 5, 2034 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 11419867 Nov. 5, 2034 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 11426370 Nov. 5, 2034 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 11426401 Nov. 5, 2034 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 11433067 Nov. 5, 2034 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 11439636 Nov. 5, 2034 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 9168234 Nov. 5, 2034 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 9198905 Nov. 5, 2034 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 9205083 Nov. 5, 2034 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 9238032 Nov. 5, 2034 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 9278095 Nov. 5, 2034 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 9314462 Nov. 5, 2034 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 9370513 Nov. 5, 2034 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 9375429 Nov. 5, 2034 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 9408815 Nov. 5, 2034 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 9421176 Nov. 5, 2034 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 9457023 Nov. 5, 2034 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 9457025 Nov. 5, 2034 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 9474731 Nov. 5, 2034 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 9486450 Nov. 5, 2034 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 9700528 Nov. 5, 2034 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 9700553 Nov. 5, 2034 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 9707191 Nov. 5, 2034 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 9763932 Nov. 5, 2034 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 9861595 Nov. 5, 2034 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 9867819 Nov. 5, 2034 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 9968568 Nov. 5, 2034 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 10780066 Nov. 9, 2034 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 10780064 Jan. 7, 2040 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 10925842 Jan. 7, 2040 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 10940124 Jan. 7, 2040 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL 10966942 Jan. 7, 2040 DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
105MG;45MG AUVELITY AXSOME N215430 Aug. 18, 2022 RX TABLET, EXTENDED RELEASE ORAL Aug. 18, 2025 NEW PRODUCT

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Sodium-dependent dopamine transporter Transporter INHIBITOR Kd 6.28 WOMBAT-PK CHEMBL
Sodium-dependent noradrenaline transporter Transporter INHIBITOR Ki 5.16 CHEMBL CHEMBL
Cytochrome P450 2D6 Enzyme WOMBAT-PK
Neuronal acetylcholine receptor subunit alpha-7 Ion channel IC50 4.30 CHEMBL
Cytochrome P450 2C19 Enzyme IC50 5.70 DRUG MATRIX
Neuronal acetylcholine receptor; alpha3/beta4 Ion channel IC50 5.74 CHEMBL
Sodium-dependent serotonin transporter Transporter Kd 5.04 WOMBAT-PK
Neuronal acetylcholine receptor; alpha3/beta2 Ion channel IC50 6 CHEMBL
Alpha-1A adrenergic receptor GPCR Ki 4.80 PDSP
Membrane-associated progesterone receptor component 1 Membrane receptor Ki 5.85 DRUG MATRIX
Sodium-dependent dopamine transporter Transporter IC50 5.91 CHEMBL

External reference:

IDSource
4019645 VUID
N0000147738 NUI
D00817 KEGG_DRUG
31677-93-7 SECONDARY_CAS_RN
905818-69-1 SECONDARY_CAS_RN
203204 RXNORM
4019483 VANDF
4019645 VANDF
4029878 VANDF
C0085208 UMLSCUI
CHEBI:3219 CHEBI
CHEMBL894 ChEMBL_ID
DB01156 DRUGBANK_ID
CHEMBL1201735 ChEMBL_ID
CHEMBL1698 ChEMBL_ID
D016642 MESH_DESCRIPTOR_UI
444 PUBCHEM_CID
7135 IUPHAR_LIGAND_ID
3562 INN_ID
01ZG3TPX31 UNII
162122 MMSL
26259 MMSL
31548 MMSL
4307 MMSL
4319 MMSL
d00181 MMSL
001512 NDDF
004611 NDDF
012996 NDDF
387564004 SNOMEDCT_US
395733003 SNOMEDCT_US
431408005 SNOMEDCT_US
96199001 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Bupropion Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0115-5445 TABLET, FILM COATED, EXTENDED RELEASE 200 mg ORAL ANDA 30 sections
Bupropion Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0115-6811 TABLET, FILM COATED, EXTENDED RELEASE 150 mg ORAL ANDA 30 sections
Bupropion Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0115-6811 TABLET, FILM COATED, EXTENDED RELEASE 150 mg ORAL ANDA 30 sections
WELLBUTRINSR HUMAN PRESCRIPTION DRUG LABEL 1 0173-0135 TABLET, FILM COATED 150 mg ORAL NDA 29 sections
WELLBUTRINSR HUMAN PRESCRIPTION DRUG LABEL 1 0173-0135 TABLET, FILM COATED 150 mg ORAL NDA 29 sections
WELLBUTRINSR HUMAN PRESCRIPTION DRUG LABEL 1 0173-0135 TABLET, FILM COATED 150 mg ORAL NDA 29 sections
WELLBUTRINSR HUMAN PRESCRIPTION DRUG LABEL 1 0173-0722 TABLET, FILM COATED 200 mg ORAL NDA 29 sections
WELLBUTRINSR HUMAN PRESCRIPTION DRUG LABEL 1 0173-0722 TABLET, FILM COATED 200 mg ORAL NDA 29 sections
WELLBUTRINSR HUMAN PRESCRIPTION DRUG LABEL 1 0173-0722 TABLET, FILM COATED 200 mg ORAL NDA 29 sections
WELLBUTRINSR HUMAN PRESCRIPTION DRUG LABEL 1 0173-0947 TABLET, FILM COATED 100 mg ORAL NDA 29 sections
WELLBUTRINSR HUMAN PRESCRIPTION DRUG LABEL 1 0173-0947 TABLET, FILM COATED 100 mg ORAL NDA 29 sections
WELLBUTRINSR HUMAN PRESCRIPTION DRUG LABEL 1 0173-0947 TABLET, FILM COATED 100 mg ORAL NDA 29 sections
Bupropion Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0185-0410 TABLET, EXTENDED RELEASE 100 mg ORAL ANDA 29 sections
Bupropion Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0185-0410 TABLET, EXTENDED RELEASE 100 mg ORAL ANDA 29 sections
Bupropion Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0185-0415 TABLET, EXTENDED RELEASE 150 mg ORAL ANDA 29 sections
Bupropion Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0185-0415 TABLET, EXTENDED RELEASE 150 mg ORAL ANDA 29 sections
Bupropion Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0185-1111 TABLET, EXTENDED RELEASE 200 mg ORAL ANDA 29 sections
Bupropion Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0185-1111 TABLET, EXTENDED RELEASE 200 mg ORAL ANDA 29 sections
WELLBUTRINXL HUMAN PRESCRIPTION DRUG LABEL 1 0187-0730 TABLET, EXTENDED RELEASE 150 mg ORAL NDA 28 sections
WELLBUTRINXL HUMAN PRESCRIPTION DRUG LABEL 1 0187-0730 TABLET, EXTENDED RELEASE 150 mg ORAL NDA 28 sections
WELLBUTRINXL HUMAN PRESCRIPTION DRUG LABEL 1 0187-0731 TABLET, EXTENDED RELEASE 300 mg ORAL NDA 28 sections
WELLBUTRINXL HUMAN PRESCRIPTION DRUG LABEL 1 0187-0731 TABLET, EXTENDED RELEASE 300 mg ORAL NDA 28 sections
Aplenzin HUMAN PRESCRIPTION DRUG LABEL 1 0187-5810 TABLET, EXTENDED RELEASE 174 mg ORAL NDA 29 sections
Aplenzin HUMAN PRESCRIPTION DRUG LABEL 1 0187-5810 TABLET, EXTENDED RELEASE 174 mg ORAL NDA 29 sections
Aplenzin HUMAN PRESCRIPTION DRUG LABEL 1 0187-5811 TABLET, EXTENDED RELEASE 348 mg ORAL NDA 29 sections
Aplenzin HUMAN PRESCRIPTION DRUG LABEL 1 0187-5811 TABLET, EXTENDED RELEASE 348 mg ORAL NDA 29 sections
Aplenzin HUMAN PRESCRIPTION DRUG LABEL 1 0187-5812 TABLET, EXTENDED RELEASE 522 mg ORAL NDA 29 sections
Aplenzin HUMAN PRESCRIPTION DRUG LABEL 1 0187-5812 TABLET, EXTENDED RELEASE 522 mg ORAL NDA 29 sections
Bupropion Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0440-7200 TABLET, FILM COATED, EXTENDED RELEASE 150 mg ORAL ANDA 28 sections
Bupropion hydrochloride (XL) HUMAN PRESCRIPTION DRUG LABEL 1 0527-2415 TABLET, EXTENDED RELEASE 150 mg ORAL ANDA 21 sections