Stem definition | Drug id | CAS RN |
---|---|---|
anorexics | 435 | 34911-55-2 |
Dose | Unit | Route |
---|---|---|
0.30 | g | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 312 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 0.50 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 31.28 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
Date | Agency | Company | Orphan |
---|---|---|---|
Dec. 30, 1985 | FDA | GLAXOSMITHKLINE |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Completed suicide | 3323.90 | 9.92 | 2686 | 122561 | 129203 | 50350674 |
Toxicity to various agents | 805.92 | 9.92 | 1683 | 123564 | 210816 | 50269061 |
Overdose | 460.58 | 9.92 | 859 | 124388 | 98868 | 50381009 |
Intentional overdose | 450.32 | 9.92 | 658 | 124589 | 61846 | 50418031 |
Seizure | 412.78 | 9.92 | 905 | 124342 | 116969 | 50362908 |
Generalised tonic-clonic seizure | 409.98 | 9.92 | 410 | 124837 | 25900 | 50453977 |
Depression | 371.03 | 9.92 | 1072 | 124175 | 164351 | 50315526 |
Anxiety | 366.13 | 9.92 | 1117 | 124130 | 176489 | 50303388 |
Suicidal ideation | 353.31 | 9.92 | 551 | 124696 | 54834 | 50425043 |
Cardio-respiratory arrest | 332.47 | 9.92 | 528 | 124719 | 53364 | 50426513 |
Suspected suicide | 326.58 | 9.92 | 189 | 125058 | 5168 | 50474709 |
Product substitution issue | 293.92 | 9.92 | 258 | 124989 | 13799 | 50466078 |
Serotonin syndrome | 269.30 | 9.92 | 319 | 124928 | 24394 | 50455483 |
Electrocardiogram QRS complex prolonged | 237.34 | 9.92 | 154 | 125093 | 5190 | 50474687 |
Suicide attempt | 234.07 | 9.92 | 442 | 124805 | 51290 | 50428587 |
Cardiac arrest | 231.30 | 9.92 | 586 | 124661 | 83065 | 50396812 |
Temperature regulation disorder | 220.79 | 9.92 | 135 | 125112 | 4092 | 50475785 |
Status epilepticus | 203.44 | 9.92 | 206 | 125041 | 13200 | 50466677 |
Agitation | 197.03 | 9.92 | 419 | 124828 | 52965 | 50426912 |
Respiratory arrest | 178.12 | 9.92 | 289 | 124958 | 29720 | 50450157 |
Mydriasis | 171.77 | 9.92 | 169 | 125078 | 10458 | 50469419 |
Irritability | 170.41 | 9.92 | 275 | 124972 | 28151 | 50451726 |
Pemphigus | 167.68 | 9.92 | 45 | 125202 | 120121 | 50359756 |
Drug withdrawal syndrome | 167.52 | 9.92 | 255 | 124992 | 24826 | 50455051 |
Coeliac disease | 162.98 | 9.92 | 150 | 125097 | 8535 | 50471342 |
Systemic lupus erythematosus | 152.18 | 9.92 | 79 | 125168 | 140543 | 50339334 |
Food allergy | 151.65 | 9.92 | 140 | 125107 | 7997 | 50471880 |
Neutropenia | 143.32 | 9.92 | 95 | 125152 | 147870 | 50332007 |
Swelling | 141.96 | 9.92 | 173 | 125074 | 200699 | 50279178 |
Asthma | 141.05 | 9.92 | 514 | 124733 | 88823 | 50391054 |
Poisoning | 139.63 | 9.92 | 163 | 125084 | 12266 | 50467611 |
Tremor | 138.79 | 9.92 | 608 | 124639 | 114295 | 50365582 |
Thrombocytopenia | 137.74 | 9.92 | 72 | 125175 | 127601 | 50352276 |
Anaemia | 134.77 | 9.92 | 263 | 124984 | 252193 | 50227684 |
Electrocardiogram QT prolonged | 134.60 | 9.92 | 355 | 124892 | 51531 | 50428346 |
Hyperhidrosis | 134.06 | 9.92 | 506 | 124741 | 88920 | 50390957 |
Sinus tachycardia | 128.55 | 9.92 | 207 | 125040 | 21147 | 50458730 |
Sleep apnoea syndrome | 127.13 | 9.92 | 219 | 125028 | 23649 | 50456228 |
White blood cell count abnormal | 126.22 | 9.92 | 106 | 125141 | 5334 | 50474543 |
Pyrexia | 124.35 | 9.92 | 502 | 124745 | 379701 | 50100176 |
Acute kidney injury | 123.96 | 9.92 | 235 | 125012 | 227823 | 50252054 |
Glossodynia | 123.44 | 9.92 | 66 | 125181 | 115503 | 50364374 |
Insomnia | 121.75 | 9.92 | 795 | 124452 | 174070 | 50305807 |
Hand deformity | 121.33 | 9.92 | 48 | 125199 | 100151 | 50379726 |
Arthropathy | 116.90 | 9.92 | 131 | 125116 | 157775 | 50322102 |
Febrile neutropenia | 114.67 | 9.92 | 49 | 125198 | 97618 | 50382259 |
Immunodeficiency | 112.35 | 9.92 | 160 | 125087 | 14668 | 50465209 |
Maternal exposure during pregnancy | 110.34 | 9.92 | 140 | 125107 | 159638 | 50320239 |
Joint swelling | 105.48 | 9.92 | 287 | 124960 | 244999 | 50234878 |
Helicobacter infection | 105.36 | 9.92 | 4 | 125243 | 49698 | 50430179 |
Treatment failure | 100.97 | 9.92 | 115 | 125132 | 137522 | 50342355 |
Pancytopenia | 100.51 | 9.92 | 41 | 125206 | 83989 | 50395888 |
Withdrawal syndrome | 98.44 | 9.92 | 165 | 125082 | 17425 | 50462452 |
General physical health deterioration | 97.10 | 9.92 | 126 | 125121 | 142308 | 50337569 |
Sensitisation | 96.91 | 9.92 | 56 | 125191 | 1526 | 50478351 |
Duodenal ulcer perforation | 95.57 | 9.92 | 4 | 125243 | 45607 | 50434270 |
Peripheral swelling | 95.40 | 9.92 | 232 | 125015 | 205704 | 50274173 |
Infusion related reaction | 95.38 | 9.92 | 171 | 125076 | 169386 | 50310491 |
Headache | 92.80 | 9.92 | 1763 | 123484 | 504772 | 49975105 |
Therapeutic response unexpected | 92.70 | 9.92 | 152 | 125095 | 15763 | 50464114 |
Polycystic ovaries | 92.10 | 9.92 | 64 | 125183 | 2420 | 50477457 |
Anger | 89.88 | 9.92 | 125 | 125122 | 11208 | 50468669 |
Cardiac failure | 89.49 | 9.92 | 38 | 125209 | 76002 | 50403875 |
Drug hypersensitivity | 88.47 | 9.92 | 980 | 124267 | 250030 | 50229847 |
Drug abuse | 88.30 | 9.92 | 337 | 124910 | 59509 | 50420368 |
Feeling abnormal | 88.16 | 9.92 | 572 | 124675 | 124920 | 50354957 |
Malignant neoplasm progression | 83.50 | 9.92 | 32 | 125215 | 68092 | 50411785 |
Bursitis | 83.09 | 9.92 | 175 | 125072 | 21960 | 50457917 |
Exposure via ingestion | 82.94 | 9.92 | 63 | 125184 | 2740 | 50477137 |
Memory impairment | 80.36 | 9.92 | 399 | 124848 | 78961 | 50400916 |
Myoclonus | 79.99 | 9.92 | 135 | 125112 | 14335 | 50465542 |
Infarction | 79.41 | 9.92 | 57 | 125190 | 2271 | 50477606 |
Product odour abnormal | 79.25 | 9.92 | 43 | 125204 | 1034 | 50478843 |
Ejection fraction | 77.59 | 9.92 | 44 | 125203 | 1156 | 50478721 |
Crying | 77.32 | 9.92 | 162 | 125085 | 20254 | 50459623 |
Blister | 75.93 | 9.92 | 60 | 125187 | 85358 | 50394519 |
Pericarditis | 74.17 | 9.92 | 52 | 125195 | 78637 | 50401240 |
Sympathomimetic effect | 73.97 | 9.92 | 19 | 125228 | 39 | 50479838 |
Dyspnoea | 73.92 | 9.92 | 935 | 124312 | 546673 | 49933204 |
Psoriasis | 73.50 | 9.92 | 352 | 124895 | 68648 | 50411229 |
Muscle injury | 72.33 | 9.92 | 5 | 125242 | 37106 | 50442771 |
Rash | 72.00 | 9.92 | 714 | 124533 | 436757 | 50043120 |
Mental status changes | 71.58 | 9.92 | 225 | 125022 | 36047 | 50443830 |
Tardive dyskinesia | 71.21 | 9.92 | 89 | 125158 | 7190 | 50472687 |
Lower respiratory tract infection | 70.39 | 9.92 | 79 | 125168 | 95122 | 50384755 |
Alopecia | 69.42 | 9.92 | 341 | 124906 | 244706 | 50235171 |
Diarrhoea | 68.62 | 9.92 | 1035 | 124212 | 587441 | 49892436 |
Pulseless electrical activity | 67.49 | 9.92 | 84 | 125163 | 6757 | 50473120 |
Anti-cyclic citrullinated peptide antibody positive | 67.38 | 9.92 | 46 | 125201 | 70541 | 50409336 |
Abdominal discomfort | 66.97 | 9.92 | 320 | 124927 | 231321 | 50248556 |
Migraine | 66.89 | 9.92 | 365 | 124882 | 74915 | 50404962 |
Postmortem blood drug level increased | 65.58 | 9.92 | 31 | 125216 | 551 | 50479326 |
Atrial fibrillation | 65.29 | 9.92 | 94 | 125153 | 101651 | 50378226 |
Postictal state | 64.59 | 9.92 | 36 | 125211 | 914 | 50478963 |
Disturbance in attention | 63.90 | 9.92 | 196 | 125051 | 30990 | 50448887 |
Sepsis | 62.90 | 9.92 | 148 | 125099 | 132777 | 50347100 |
Panic attack | 62.50 | 9.92 | 144 | 125103 | 19198 | 50460679 |
Folliculitis | 62.16 | 9.92 | 11 | 125236 | 39214 | 50440663 |
Cholecystitis chronic | 59.93 | 9.92 | 95 | 125152 | 9574 | 50470303 |
Cerebral venous thrombosis | 59.70 | 9.92 | 44 | 125203 | 1827 | 50478050 |
Weight increased | 59.08 | 9.92 | 761 | 124486 | 201130 | 50278747 |
Product residue present | 58.60 | 9.92 | 58 | 125189 | 3614 | 50476263 |
Synovitis | 57.73 | 9.92 | 139 | 125108 | 123726 | 50356151 |
Platelet count decreased | 57.13 | 9.92 | 101 | 125146 | 100625 | 50379252 |
Renal impairment | 56.79 | 9.92 | 62 | 125185 | 75599 | 50404278 |
Pneumonia | 56.34 | 9.92 | 632 | 124615 | 377769 | 50102108 |
Bone marrow failure | 56.01 | 9.92 | 3 | 125244 | 27621 | 50452256 |
Bronchial neoplasm | 54.82 | 9.92 | 25 | 125222 | 408 | 50479469 |
Disease progression | 54.48 | 9.92 | 96 | 125151 | 95770 | 50384107 |
Hyperkalaemia | 53.50 | 9.92 | 26 | 125221 | 48063 | 50431814 |
Brain injury | 53.27 | 9.92 | 70 | 125177 | 5944 | 50473933 |
Hyponatraemia | 53.09 | 9.92 | 98 | 125149 | 96041 | 50383836 |
Gastrointestinal disorder | 52.41 | 9.92 | 96 | 125151 | 94360 | 50385517 |
Areflexia | 52.13 | 9.92 | 48 | 125199 | 2732 | 50477145 |
Hepatocellular injury | 52.04 | 9.92 | 3 | 125244 | 25944 | 50453933 |
Sleep-related eating disorder | 51.93 | 9.92 | 29 | 125218 | 739 | 50479138 |
Mental disorder | 51.54 | 9.92 | 145 | 125102 | 21846 | 50458031 |
Wound | 51.48 | 9.92 | 116 | 125131 | 105678 | 50374199 |
Bipolar disorder | 51.31 | 9.92 | 73 | 125174 | 6684 | 50473193 |
Tachycardia | 51.22 | 9.92 | 422 | 124825 | 99341 | 50380536 |
Haemoglobin decreased | 50.83 | 9.92 | 154 | 125093 | 127062 | 50352815 |
Nicotine dependence | 50.57 | 9.92 | 27 | 125220 | 628 | 50479249 |
Multiple organ dysfunction syndrome | 50.50 | 9.92 | 31 | 125216 | 50306 | 50429571 |
Bronchial haemorrhage | 50.45 | 9.92 | 25 | 125222 | 495 | 50479382 |
Persistent genital arousal disorder | 49.98 | 9.92 | 20 | 125227 | 232 | 50479645 |
Discomfort | 48.64 | 9.92 | 124 | 125123 | 108256 | 50371621 |
Asthma exercise induced | 48.22 | 9.92 | 20 | 125227 | 256 | 50479621 |
Factor V Leiden mutation | 48.08 | 9.92 | 18 | 125229 | 172 | 50479705 |
Cardiogenic shock | 48.06 | 9.92 | 114 | 125133 | 15485 | 50464392 |
Rash erythematous | 47.93 | 9.92 | 192 | 125055 | 34660 | 50445217 |
Stomatitis | 47.00 | 9.92 | 114 | 125133 | 101230 | 50378647 |
Multiple sclerosis relapse | 46.33 | 9.92 | 220 | 125027 | 42744 | 50437133 |
Mucosal inflammation | 45.74 | 9.92 | 21 | 125226 | 40121 | 50439756 |
Neutrophil count decreased | 45.27 | 9.92 | 29 | 125218 | 45997 | 50433880 |
Leukopenia | 44.69 | 9.92 | 61 | 125186 | 67467 | 50412410 |
Nasal turbinate hypertrophy | 44.49 | 9.92 | 25 | 125222 | 645 | 50479232 |
Emotional distress | 44.41 | 9.92 | 164 | 125083 | 28499 | 50451378 |
Hepatic function abnormal | 44.14 | 9.92 | 13 | 125234 | 32668 | 50447209 |
Infection | 43.74 | 9.92 | 250 | 124997 | 172704 | 50307173 |
Rubber sensitivity | 43.52 | 9.92 | 36 | 125211 | 1773 | 50478104 |
Intentional product misuse | 43.13 | 9.92 | 229 | 125018 | 46505 | 50433372 |
Hyperreflexia | 42.92 | 9.92 | 58 | 125189 | 5060 | 50474817 |
Hallucination | 42.63 | 9.92 | 228 | 125019 | 46429 | 50433448 |
Product complaint | 42.27 | 9.92 | 90 | 125157 | 11376 | 50468501 |
Mood altered | 42.26 | 9.92 | 96 | 125151 | 12677 | 50467200 |
Hostility | 41.91 | 9.92 | 35 | 125212 | 1747 | 50478130 |
Septic shock | 41.65 | 9.92 | 48 | 125199 | 57127 | 50422750 |
Brugada syndrome | 41.61 | 9.92 | 19 | 125228 | 311 | 50479566 |
Multiple sclerosis | 41.24 | 9.92 | 128 | 125119 | 20365 | 50459512 |
Pleural effusion | 40.70 | 9.92 | 88 | 125159 | 81366 | 50398511 |
Cholestasis | 40.51 | 9.92 | 7 | 125240 | 25394 | 50454483 |
Gastrointestinal haemorrhage | 40.24 | 9.92 | 75 | 125172 | 73246 | 50406631 |
Hypokalaemia | 40.00 | 9.92 | 100 | 125147 | 87892 | 50391985 |
Drug intolerance | 39.62 | 9.92 | 349 | 124898 | 218755 | 50261122 |
Foot deformity | 39.60 | 9.92 | 121 | 125126 | 19089 | 50460788 |
Depressed mood | 39.48 | 9.92 | 178 | 125069 | 33845 | 50446032 |
Affective disorder | 39.38 | 9.92 | 56 | 125191 | 5125 | 50474752 |
Libido increased | 39.14 | 9.92 | 29 | 125218 | 1214 | 50478663 |
Joint dislocation | 38.94 | 9.92 | 91 | 125156 | 12242 | 50467635 |
Impaired healing | 38.64 | 9.92 | 71 | 125176 | 69715 | 50410162 |
Endometrial ablation | 38.64 | 9.92 | 25 | 125222 | 838 | 50479039 |
White blood cell count decreased | 37.45 | 9.92 | 155 | 125092 | 116567 | 50363310 |
Muscle twitching | 37.40 | 9.92 | 103 | 125144 | 15328 | 50464549 |
Arthralgia | 36.99 | 9.92 | 816 | 124431 | 437886 | 50041991 |
Rhinitis allergic | 36.94 | 9.92 | 65 | 125182 | 7135 | 50472742 |
Nephrectomy | 36.92 | 9.92 | 24 | 125223 | 811 | 50479066 |
Vertigo | 36.81 | 9.92 | 237 | 125010 | 51595 | 50428282 |
Hallucinations, mixed | 36.72 | 9.92 | 48 | 125199 | 4055 | 50475822 |
Nightmare | 36.66 | 9.92 | 105 | 125142 | 15981 | 50463896 |
Impulse-control disorder | 36.54 | 9.92 | 22 | 125225 | 648 | 50479229 |
Pre-existing condition improved | 36.32 | 9.92 | 64 | 125183 | 7033 | 50472844 |
Lung disorder | 35.54 | 9.92 | 35 | 125212 | 44764 | 50435113 |
Pupil fixed | 35.51 | 9.92 | 30 | 125217 | 1522 | 50478355 |
Hepatic failure | 35.09 | 9.92 | 18 | 125229 | 32265 | 50447612 |
Fluid retention | 34.99 | 9.92 | 230 | 125017 | 50419 | 50429458 |
Sleep disorder due to general medical condition, insomnia type | 34.98 | 9.92 | 17 | 125230 | 31430 | 50448447 |
Exostosis | 34.65 | 9.92 | 84 | 125163 | 11569 | 50468308 |
Nasopharyngitis | 34.57 | 9.92 | 308 | 124939 | 192619 | 50287258 |
Retinitis | 34.26 | 9.92 | 32 | 125215 | 1855 | 50478022 |
Pruritus | 34.18 | 9.92 | 495 | 124752 | 283073 | 50196804 |
Abnormal dreams | 33.87 | 9.92 | 73 | 125174 | 9304 | 50470573 |
Mania | 33.87 | 9.92 | 80 | 125167 | 10836 | 50469041 |
Hypoglycaemia | 33.87 | 9.92 | 50 | 125197 | 53531 | 50426346 |
Choreoathetosis | 33.54 | 9.92 | 18 | 125229 | 423 | 50479454 |
Fibromyalgia | 33.38 | 9.92 | 208 | 125039 | 44770 | 50435107 |
Liver disorder | 33.25 | 9.92 | 26 | 125221 | 37196 | 50442681 |
Sleep paralysis | 33.04 | 9.92 | 19 | 125228 | 513 | 50479364 |
Thinking abnormal | 32.88 | 9.92 | 73 | 125174 | 9494 | 50470383 |
International normalised ratio increased | 32.78 | 9.92 | 35 | 125212 | 43117 | 50436760 |
Renal failure | 32.74 | 9.92 | 144 | 125103 | 106489 | 50373388 |
Drug eruption | 32.60 | 9.92 | 9 | 125238 | 23597 | 50456280 |
C-reactive protein abnormal | 32.54 | 9.92 | 14 | 125233 | 27795 | 50452082 |
Amnesia | 32.35 | 9.92 | 197 | 125050 | 42063 | 50437814 |
Upper respiratory tract infection | 32.34 | 9.92 | 276 | 124971 | 65622 | 50414255 |
Bronchial disorder | 32.33 | 9.92 | 25 | 125222 | 1117 | 50478760 |
Lupus-like syndrome | 32.15 | 9.92 | 72 | 125175 | 9419 | 50470458 |
Akathisia | 31.98 | 9.92 | 66 | 125181 | 8163 | 50471714 |
Stress | 31.71 | 9.92 | 235 | 125012 | 53558 | 50426319 |
Libido decreased | 31.54 | 9.92 | 34 | 125213 | 2342 | 50477535 |
Epistaxis | 31.20 | 9.92 | 70 | 125177 | 63884 | 50415993 |
Bruxism | 31.07 | 9.92 | 38 | 125209 | 3002 | 50476875 |
Drug screen positive | 30.76 | 9.92 | 40 | 125207 | 3362 | 50476515 |
Ascites | 29.64 | 9.92 | 27 | 125220 | 35834 | 50444043 |
Endometriosis | 29.44 | 9.92 | 43 | 125204 | 4032 | 50475845 |
Thermal burn | 29.23 | 9.92 | 47 | 125200 | 4794 | 50475083 |
Gambling disorder | 29.23 | 9.92 | 24 | 125223 | 1170 | 50478707 |
Death | 29.20 | 9.92 | 599 | 124648 | 324780 | 50155097 |
Carpal tunnel syndrome | 29.03 | 9.92 | 100 | 125147 | 16793 | 50463084 |
Economic problem | 28.69 | 9.92 | 29 | 125218 | 1853 | 50478024 |
Gamma-glutamyltransferase increased | 28.67 | 9.92 | 19 | 125228 | 29604 | 50450273 |
Hypercalcaemia | 28.56 | 9.92 | 11 | 125236 | 23341 | 50456536 |
Feeling jittery | 28.56 | 9.92 | 76 | 125171 | 11084 | 50468793 |
Rheumatic fever | 28.37 | 9.92 | 4 | 125243 | 16863 | 50463014 |
Urine sodium increased | 28.05 | 9.92 | 10 | 125237 | 82 | 50479795 |
Vision blurred | 28.04 | 9.92 | 308 | 124939 | 78339 | 50401538 |
Affect lability | 27.98 | 9.92 | 66 | 125181 | 8932 | 50470945 |
Automatism | 27.94 | 9.92 | 9 | 125238 | 52 | 50479825 |
Product quality issue | 27.65 | 9.92 | 150 | 125097 | 30708 | 50449169 |
Central nervous system necrosis | 27.46 | 9.92 | 11 | 125236 | 128 | 50479749 |
Toxic epidermal necrolysis | 27.18 | 9.92 | 9 | 125238 | 20983 | 50458894 |
Brain death | 27.18 | 9.92 | 34 | 125213 | 2749 | 50477128 |
Anorgasmia | 27.14 | 9.92 | 17 | 125230 | 538 | 50479339 |
Sputum purulent | 27.08 | 9.92 | 21 | 125226 | 942 | 50478935 |
Anti-neutrophil cytoplasmic antibody positive vasculitis | 26.99 | 9.92 | 31 | 125216 | 2291 | 50477586 |
Jaundice | 26.89 | 9.92 | 16 | 125231 | 26413 | 50453464 |
Myelodysplastic syndrome | 26.88 | 9.92 | 3 | 125244 | 15129 | 50464748 |
Electroencephalogram abnormal | 26.86 | 9.92 | 38 | 125209 | 3461 | 50476416 |
Obsessive-compulsive disorder | 26.72 | 9.92 | 37 | 125210 | 3303 | 50476574 |
Hypothyroidism | 26.71 | 9.92 | 160 | 125087 | 33965 | 50445912 |
Somnolence | 26.67 | 9.92 | 535 | 124712 | 154450 | 50325427 |
Cerebral haemorrhage | 26.66 | 9.92 | 17 | 125230 | 27035 | 50452842 |
Anhedonia | 26.57 | 9.92 | 67 | 125180 | 9457 | 50470420 |
Restless legs syndrome | 26.36 | 9.92 | 93 | 125154 | 15804 | 50464073 |
Tachyphrenia | 26.32 | 9.92 | 23 | 125224 | 1222 | 50478655 |
Dyskinesia | 26.03 | 9.92 | 137 | 125110 | 27724 | 50452153 |
Mucosal dryness | 25.99 | 9.92 | 31 | 125216 | 2386 | 50477491 |
Off label use | 25.98 | 9.92 | 937 | 124310 | 473489 | 50006388 |
Syncope | 25.96 | 9.92 | 149 | 125098 | 102853 | 50377024 |
Hallucination, auditory | 25.39 | 9.92 | 71 | 125176 | 10657 | 50469220 |
Major depression | 25.34 | 9.92 | 54 | 125193 | 6830 | 50473047 |
Feeling of despair | 25.27 | 9.92 | 28 | 125219 | 1990 | 50477887 |
Thalamic infarction | 25.21 | 9.92 | 15 | 125232 | 432 | 50479445 |
Urine osmolarity increased | 24.99 | 9.92 | 10 | 125237 | 116 | 50479761 |
Melaena | 24.98 | 9.92 | 18 | 125229 | 26846 | 50453031 |
Unresponsive to stimuli | 24.91 | 9.92 | 145 | 125102 | 30464 | 50449413 |
Tinnitus | 24.70 | 9.92 | 136 | 125111 | 27996 | 50451881 |
Hepatotoxicity | 24.34 | 9.92 | 19 | 125228 | 27207 | 50452670 |
Blood lactate dehydrogenase increased | 24.28 | 9.92 | 9 | 125238 | 19553 | 50460324 |
Binge eating | 24.18 | 9.92 | 14 | 125233 | 383 | 50479494 |
Posterior reversible encephalopathy syndrome | 24.06 | 9.92 | 4 | 125243 | 14924 | 50464953 |
Osteonecrosis of jaw | 24.02 | 9.92 | 27 | 125220 | 32499 | 50447378 |
Gastrooesophageal reflux disease | 23.98 | 9.92 | 292 | 124955 | 76136 | 50403741 |
Haematemesis | 23.97 | 9.92 | 20 | 125227 | 27705 | 50452172 |
Supraventricular tachycardia | 23.97 | 9.92 | 78 | 125169 | 12723 | 50467154 |
Swollen joint count increased | 23.94 | 9.92 | 4 | 125243 | 14869 | 50465008 |
Decreased interest | 23.86 | 9.92 | 33 | 125214 | 2943 | 50476934 |
Dysphemia | 23.85 | 9.92 | 29 | 125218 | 2277 | 50477600 |
Nervousness | 23.83 | 9.92 | 133 | 125114 | 27518 | 50452359 |
Large intestine anastomosis | 23.64 | 9.92 | 7 | 125240 | 29 | 50479848 |
Post-traumatic stress disorder | 23.59 | 9.92 | 40 | 125207 | 4263 | 50475614 |
Accidental exposure to product by child | 23.58 | 9.92 | 20 | 125227 | 1020 | 50478857 |
Dyspnoea exertional | 23.45 | 9.92 | 58 | 125189 | 51175 | 50428702 |
Adrenergic syndrome | 23.45 | 9.92 | 7 | 125240 | 30 | 50479847 |
Asthenia | 23.37 | 9.92 | 606 | 124641 | 318436 | 50161441 |
Hepatitis | 23.34 | 9.92 | 26 | 125221 | 31427 | 50448450 |
Haemorrhage | 23.31 | 9.92 | 62 | 125185 | 53379 | 50426498 |
Rash maculo-papular | 23.30 | 9.92 | 19 | 125228 | 26622 | 50453255 |
Erythema dyschromicum perstans | 23.29 | 9.92 | 8 | 125239 | 58 | 50479819 |
Secondary immunodeficiency | 23.23 | 9.92 | 21 | 125226 | 1167 | 50478710 |
Product use issue | 23.23 | 9.92 | 247 | 125000 | 149228 | 50330649 |
Agranulocytosis | 23.20 | 9.92 | 12 | 125235 | 21409 | 50458468 |
Irritable bowel syndrome | 22.96 | 9.92 | 59 | 125188 | 51382 | 50428495 |
Complication of device insertion | 22.94 | 9.92 | 48 | 125199 | 5993 | 50473884 |
Soft tissue injury | 22.87 | 9.92 | 23 | 125224 | 1461 | 50478416 |
Hip arthroplasty | 22.75 | 9.92 | 25 | 125222 | 30404 | 50449473 |
Treatment noncompliance | 22.73 | 9.92 | 140 | 125107 | 30010 | 50449867 |
Sexual dysfunction | 22.72 | 9.92 | 34 | 125213 | 3258 | 50476619 |
Attention deficit hyperactivity disorder | 22.65 | 9.92 | 29 | 125218 | 2400 | 50477477 |
Oesophageal pain | 22.36 | 9.92 | 31 | 125216 | 2771 | 50477106 |
Lactic acidosis | 22.20 | 9.92 | 30 | 125217 | 33325 | 50446552 |
Blood creatinine increased | 22.09 | 9.92 | 105 | 125142 | 76055 | 50403822 |
Oppositional defiant disorder | 21.95 | 9.92 | 7 | 125240 | 39 | 50479838 |
Hepatic cirrhosis | 21.94 | 9.92 | 94 | 125153 | 17483 | 50462394 |
Drug dependence | 21.90 | 9.92 | 102 | 125145 | 19657 | 50460220 |
Therapeutic product effect incomplete | 21.88 | 9.92 | 333 | 124914 | 91182 | 50388695 |
Neoplasm progression | 21.75 | 9.92 | 24 | 125223 | 29133 | 50450744 |
Ventricular tachycardia | 21.62 | 9.92 | 87 | 125160 | 15734 | 50464143 |
Interstitial lung disease | 21.49 | 9.92 | 64 | 125183 | 53112 | 50426765 |
Oedema | 21.40 | 9.92 | 95 | 125152 | 70086 | 50409791 |
Peritonitis | 21.21 | 9.92 | 6 | 125241 | 15480 | 50464397 |
Impaired work ability | 21.09 | 9.92 | 78 | 125169 | 13562 | 50466315 |
Compulsive shopping | 20.94 | 9.92 | 16 | 125231 | 702 | 50479175 |
Anticholinergic syndrome | 20.93 | 9.92 | 24 | 125223 | 1771 | 50478106 |
Oesophageal spasm | 20.76 | 9.92 | 27 | 125220 | 2269 | 50477608 |
Corneal reflex decreased | 20.66 | 9.92 | 9 | 125238 | 131 | 50479746 |
Hypotonic urinary bladder | 20.66 | 9.92 | 5 | 125242 | 7 | 50479870 |
Solar urticaria | 20.59 | 9.92 | 7 | 125240 | 49 | 50479828 |
Cardiomyopathy acute | 20.51 | 9.92 | 10 | 125237 | 191 | 50479686 |
Heart rate decreased | 20.32 | 9.92 | 37 | 125210 | 36460 | 50443417 |
Emotional disorder | 20.28 | 9.92 | 70 | 125177 | 11766 | 50468111 |
Urine amphetamine positive | 20.24 | 9.92 | 7 | 125240 | 52 | 50479825 |
Paranoia | 20.23 | 9.92 | 64 | 125183 | 10284 | 50469593 |
Liver injury | 20.12 | 9.92 | 19 | 125228 | 24787 | 50455090 |
Biliary dyskinesia | 20.03 | 9.92 | 28 | 125219 | 2522 | 50477355 |
Dystonia | 19.97 | 9.92 | 70 | 125177 | 11856 | 50468021 |
Product dose omission issue | 19.97 | 9.92 | 596 | 124651 | 183242 | 50296635 |
Rhinitis | 19.71 | 9.92 | 55 | 125192 | 8246 | 50471631 |
Hypomagnesaemia | 19.66 | 9.92 | 17 | 125230 | 23139 | 50456738 |
Self esteem decreased | 19.56 | 9.92 | 14 | 125233 | 555 | 50479322 |
Caput succedaneum | 19.55 | 9.92 | 5 | 125242 | 10 | 50479867 |
Dizziness | 19.54 | 9.92 | 1046 | 124201 | 345323 | 50134554 |
Alcoholism | 19.46 | 9.92 | 22 | 125225 | 1598 | 50478279 |
Disseminated intravascular coagulation | 19.46 | 9.92 | 9 | 125238 | 17126 | 50462751 |
Cerebral infarction | 19.41 | 9.92 | 15 | 125232 | 21589 | 50458288 |
Rhonchi | 19.13 | 9.92 | 26 | 125221 | 2281 | 50477596 |
Cough | 19.07 | 9.92 | 453 | 124794 | 240811 | 50239066 |
Bone erosion | 19.06 | 9.92 | 68 | 125179 | 11619 | 50468258 |
Sexually inappropriate behaviour | 19.04 | 9.92 | 8 | 125239 | 106 | 50479771 |
Gallbladder disorder | 18.98 | 9.92 | 87 | 125160 | 16655 | 50463222 |
Liver function test abnormal | 18.92 | 9.92 | 52 | 125195 | 44287 | 50435590 |
Apathy | 18.91 | 9.92 | 51 | 125196 | 7497 | 50472380 |
Upper gastrointestinal haemorrhage | 18.88 | 9.92 | 8 | 125239 | 16027 | 50463850 |
Sternal fracture | 18.82 | 9.92 | 24 | 125223 | 1978 | 50477899 |
Blood test abnormal | 18.58 | 9.92 | 66 | 125181 | 11253 | 50468624 |
Somnambulism | 18.56 | 9.92 | 39 | 125208 | 4885 | 50474992 |
Injury | 18.55 | 9.92 | 194 | 125053 | 48731 | 50431146 |
Neuropathy peripheral | 18.41 | 9.92 | 152 | 125095 | 96605 | 50383272 |
Femur fracture | 18.28 | 9.92 | 41 | 125206 | 37423 | 50442454 |
Infusion site scar | 18.24 | 9.92 | 11 | 125236 | 325 | 50479552 |
Dysphoria | 18.21 | 9.92 | 38 | 125209 | 4736 | 50475141 |
Pneumonitis | 18.20 | 9.92 | 28 | 125219 | 29482 | 50450395 |
Ventricular tachyarrhythmia | 18.16 | 9.92 | 7 | 125240 | 73 | 50479804 |
Burning sensation | 18.08 | 9.92 | 182 | 125065 | 45264 | 50434613 |
Clonus | 18.04 | 9.92 | 35 | 125212 | 4140 | 50475737 |
Metastases to liver | 18.01 | 9.92 | 14 | 125233 | 20090 | 50459787 |
Uterine perforation | 17.76 | 9.92 | 45 | 125202 | 6370 | 50473507 |
Knee arthroplasty | 17.67 | 9.92 | 39 | 125208 | 35807 | 50444070 |
Tongue biting | 17.60 | 9.92 | 19 | 125228 | 1311 | 50478566 |
Cortisol increased | 17.54 | 9.92 | 11 | 125236 | 349 | 50479528 |
Oscillopsia | 17.52 | 9.92 | 8 | 125239 | 131 | 50479746 |
Respiratory failure | 17.46 | 9.92 | 143 | 125104 | 91038 | 50388839 |
Blood bilirubin increased | 17.37 | 9.92 | 33 | 125214 | 32005 | 50447872 |
Product coating issue | 17.18 | 9.92 | 6 | 125241 | 46 | 50479831 |
Loss of libido | 17.12 | 9.92 | 18 | 125229 | 1205 | 50478672 |
Premature delivery | 17.08 | 9.92 | 20 | 125227 | 23643 | 50456234 |
Liver function test increased | 17.07 | 9.92 | 23 | 125224 | 25583 | 50454294 |
Herpes zoster | 16.98 | 9.92 | 104 | 125143 | 70682 | 50409195 |
Subacute cutaneous lupus erythematosus | 16.92 | 9.92 | 24 | 125223 | 2191 | 50477686 |
C-reactive protein increased | 16.83 | 9.92 | 96 | 125151 | 66378 | 50413499 |
Dermatillomania | 16.68 | 9.92 | 8 | 125239 | 147 | 50479730 |
Ill-defined disorder | 16.65 | 9.92 | 74 | 125173 | 54580 | 50425297 |
Ejection fraction abnormal | 16.62 | 9.92 | 15 | 125232 | 832 | 50479045 |
Post-traumatic neck syndrome | 16.56 | 9.92 | 22 | 125225 | 1888 | 50477989 |
Gastrointestinal sounds abnormal | 16.36 | 9.92 | 31 | 125216 | 3603 | 50476274 |
Dissociation | 16.30 | 9.92 | 24 | 125223 | 2267 | 50477610 |
Device dislocation | 16.21 | 9.92 | 100 | 125147 | 21446 | 50458431 |
Premature baby | 16.14 | 9.92 | 13 | 125234 | 18324 | 50461553 |
Right ventricular systolic pressure decreased | 16.12 | 9.92 | 5 | 125242 | 25 | 50479852 |
Narcolepsy | 16.11 | 9.92 | 17 | 125230 | 1143 | 50478734 |
Nausea | 16.04 | 9.92 | 1986 | 123261 | 703412 | 49776465 |
Iron deficiency anaemia | 16.02 | 9.92 | 11 | 125236 | 16823 | 50463054 |
Mood swings | 15.98 | 9.92 | 80 | 125167 | 15874 | 50464003 |
Sedation | 15.97 | 9.92 | 130 | 125117 | 30480 | 50449397 |
Abnormal behaviour | 15.91 | 9.92 | 93 | 125154 | 19565 | 50460312 |
Road traffic accident | 15.86 | 9.92 | 109 | 125138 | 24243 | 50455634 |
Cardiac failure congestive | 15.85 | 9.92 | 133 | 125114 | 84249 | 50395628 |
Drug specific antibody | 15.79 | 9.92 | 21 | 125226 | 1804 | 50478073 |
Urinary tract infection | 15.72 | 9.92 | 428 | 124819 | 223592 | 50256285 |
Macular degeneration | 15.67 | 9.92 | 8 | 125239 | 14380 | 50465497 |
Drug reaction with eosinophilia and systemic symptoms | 15.66 | 9.92 | 29 | 125218 | 28395 | 50451482 |
Haemangioma congenital | 15.55 | 9.92 | 11 | 125236 | 428 | 50479449 |
Haemoglobin urine | 15.42 | 9.92 | 7 | 125240 | 113 | 50479764 |
Balance disorder | 15.41 | 9.92 | 253 | 124994 | 70337 | 50409540 |
Snoring | 15.40 | 9.92 | 29 | 125218 | 3355 | 50476522 |
Encephalopathy | 15.39 | 9.92 | 139 | 125108 | 33572 | 50446305 |
Hypertonic bladder | 15.28 | 9.92 | 27 | 125220 | 2973 | 50476904 |
Skin necrosis | 15.28 | 9.92 | 4 | 125243 | 10863 | 50469014 |
Vomiting | 15.21 | 9.92 | 960 | 124287 | 459798 | 50020079 |
Euphoric mood | 15.14 | 9.92 | 32 | 125215 | 4023 | 50475854 |
Device placement issue | 15.13 | 9.92 | 14 | 125233 | 802 | 50479075 |
Decreased appetite | 15.12 | 9.92 | 380 | 124867 | 200543 | 50279334 |
Wound infection fungal | 15.04 | 9.92 | 7 | 125240 | 120 | 50479757 |
Orgasmic sensation decreased | 15.01 | 9.92 | 3 | 125244 | 0 | 50479877 |
Hypervolaemia | 14.97 | 9.92 | 25 | 125222 | 25474 | 50454403 |
Drug tolerance | 14.93 | 9.92 | 36 | 125211 | 4940 | 50474937 |
Contraindicated product administered | 14.92 | 9.92 | 269 | 124978 | 148689 | 50331188 |
Rheumatoid factor positive | 14.89 | 9.92 | 68 | 125179 | 49791 | 50430086 |
Personality disorder | 14.87 | 9.92 | 33 | 125214 | 4291 | 50475586 |
Dysgraphia | 14.85 | 9.92 | 25 | 125222 | 2648 | 50477229 |
Blood pressure systolic increased | 14.80 | 9.92 | 42 | 125205 | 35407 | 50444470 |
Hypertensive crisis | 14.80 | 9.92 | 7 | 125240 | 13147 | 50466730 |
Sleep disorder due to a general medical condition | 14.79 | 9.92 | 46 | 125201 | 7325 | 50472552 |
Exposure via breast milk | 14.68 | 9.92 | 19 | 125228 | 1589 | 50478288 |
Tenosynovitis | 14.64 | 9.92 | 4 | 125243 | 10561 | 50469316 |
Skin ulcer | 14.64 | 9.92 | 42 | 125205 | 35276 | 50444601 |
Impaired driving ability | 14.49 | 9.92 | 31 | 125216 | 3930 | 50475947 |
Sensitivity to weather change | 14.48 | 9.92 | 40 | 125207 | 5961 | 50473916 |
Gestational diabetes | 14.44 | 9.92 | 46 | 125201 | 7419 | 50472458 |
Polyneuropathy | 14.37 | 9.92 | 6 | 125241 | 12125 | 50467752 |
Metastases to bone | 14.34 | 9.92 | 14 | 125233 | 17981 | 50461896 |
Generalised anxiety disorder | 14.32 | 9.92 | 20 | 125227 | 1800 | 50478077 |
Haematuria | 14.23 | 9.92 | 26 | 125221 | 25587 | 50454290 |
Acute myeloid leukaemia | 14.15 | 9.92 | 10 | 125237 | 15064 | 50464813 |
Cholelithiasis | 14.12 | 9.92 | 150 | 125097 | 37823 | 50442054 |
Decorticate posture | 14.12 | 9.92 | 9 | 125238 | 294 | 50479583 |
Chronic fatigue syndrome | 14.07 | 9.92 | 15 | 125232 | 1020 | 50478857 |
Pelvic pain | 14.02 | 9.92 | 60 | 125187 | 11153 | 50468724 |
Obesity | 14.00 | 9.92 | 80 | 125167 | 16695 | 50463182 |
Rheumatoid arthritis | 13.98 | 9.92 | 624 | 124623 | 201926 | 50277951 |
Bipolar I disorder | 13.96 | 9.92 | 18 | 125229 | 1500 | 50478377 |
Mental impairment | 13.96 | 9.92 | 63 | 125184 | 11981 | 50467896 |
Homicidal ideation | 13.84 | 9.92 | 19 | 125228 | 1683 | 50478194 |
Pupillary reflex impaired | 13.81 | 9.92 | 20 | 125227 | 1861 | 50478016 |
False positive investigation result | 13.80 | 9.92 | 11 | 125236 | 514 | 50479363 |
Cerebrovascular accident | 13.69 | 9.92 | 159 | 125088 | 94521 | 50385356 |
Pulmonary hypertension | 13.66 | 9.92 | 40 | 125207 | 33377 | 50446500 |
Drug tolerance decreased | 13.61 | 9.92 | 3 | 125244 | 9157 | 50470720 |
Haematoma | 13.61 | 9.92 | 35 | 125212 | 30475 | 50449402 |
Poor personal hygiene | 13.54 | 9.92 | 9 | 125238 | 316 | 50479561 |
Abscess sterile | 13.52 | 9.92 | 5 | 125242 | 46 | 50479831 |
Oedema peripheral | 13.49 | 9.92 | 293 | 124954 | 157668 | 50322209 |
Palmar-plantar erythrodysaesthesia syndrome | 13.45 | 9.92 | 18 | 125229 | 20080 | 50459797 |
Forced expiratory volume decreased | 13.41 | 9.92 | 32 | 125215 | 4362 | 50475515 |
Muscle rigidity | 13.39 | 9.92 | 54 | 125193 | 9775 | 50470102 |
Pallor | 13.38 | 9.92 | 23 | 125224 | 23176 | 50456701 |
Hypocalcaemia | 13.37 | 9.92 | 29 | 125218 | 26787 | 50453090 |
Executive dysfunction | 13.34 | 9.92 | 7 | 125240 | 157 | 50479720 |
Angina pectoris | 13.32 | 9.92 | 28 | 125219 | 26160 | 50453717 |
Antidepressant discontinuation syndrome | 13.24 | 9.92 | 4 | 125243 | 18 | 50479859 |
Bone pain | 13.18 | 9.92 | 66 | 125181 | 47163 | 50432714 |
Brain stem syndrome | 13.15 | 9.92 | 9 | 125238 | 332 | 50479545 |
Food craving | 13.13 | 9.92 | 17 | 125230 | 1422 | 50478455 |
Insurance issue | 13.07 | 9.92 | 23 | 125224 | 2525 | 50477352 |
Dyspareunia | 12.94 | 9.92 | 21 | 125226 | 2158 | 50477719 |
Mobility decreased | 12.86 | 9.92 | 131 | 125116 | 79817 | 50400060 |
Flat affect | 12.83 | 9.92 | 16 | 125231 | 1289 | 50478588 |
Bipolar II disorder | 12.81 | 9.92 | 8 | 125239 | 252 | 50479625 |
Gait disturbance | 12.62 | 9.92 | 472 | 124775 | 149533 | 50330344 |
Myoglobinuria | 12.58 | 9.92 | 8 | 125239 | 260 | 50479617 |
Musculoskeletal pain | 12.57 | 9.92 | 116 | 125131 | 72061 | 50407816 |
Mass excision | 12.56 | 9.92 | 8 | 125239 | 261 | 50479616 |
Stoma site ulcer | 12.50 | 9.92 | 8 | 125239 | 263 | 50479614 |
Blood pressure fluctuation | 12.48 | 9.92 | 46 | 125201 | 35777 | 50444100 |
Pericardial effusion | 12.48 | 9.92 | 28 | 125219 | 25561 | 50454316 |
Ankle fracture | 12.48 | 9.92 | 74 | 125173 | 15648 | 50464229 |
Bezoar | 12.42 | 9.92 | 16 | 125231 | 1332 | 50478545 |
Parkinsonism | 12.37 | 9.92 | 49 | 125198 | 8798 | 50471079 |
Tooth fracture | 12.34 | 9.92 | 52 | 125195 | 9599 | 50470278 |
Galactorrhoea | 12.34 | 9.92 | 28 | 125219 | 3695 | 50476182 |
Bronchiectasis | 12.32 | 9.92 | 5 | 125242 | 10278 | 50469599 |
Carbon monoxide poisoning | 12.31 | 9.92 | 7 | 125240 | 185 | 50479692 |
Essential tremor | 12.27 | 9.92 | 13 | 125234 | 878 | 50478999 |
Device expulsion | 12.23 | 9.92 | 117 | 125130 | 28705 | 50451172 |
Panniculitis | 12.20 | 9.92 | 3 | 125244 | 8500 | 50471377 |
Coagulopathy | 12.08 | 9.92 | 16 | 125231 | 17928 | 50461949 |
Haemolytic anaemia | 12.00 | 9.92 | 4 | 125243 | 9288 | 50470589 |
Acute myocardial infarction | 11.99 | 9.92 | 35 | 125212 | 29238 | 50450639 |
Intentional self-injury | 11.97 | 9.92 | 98 | 125149 | 23014 | 50456863 |
Malaise | 11.95 | 9.92 | 694 | 124553 | 334838 | 50145039 |
Right ventricular failure | 11.95 | 9.92 | 13 | 125234 | 15880 | 50463997 |
Fear | 11.89 | 9.92 | 69 | 125178 | 14480 | 50465397 |
Suicidal behaviour | 11.88 | 9.92 | 21 | 125226 | 2313 | 50477564 |
Shock haemorrhagic | 11.87 | 9.92 | 3 | 125244 | 8341 | 50471536 |
Social anxiety disorder | 11.84 | 9.92 | 9 | 125238 | 392 | 50479485 |
Colitis | 11.83 | 9.92 | 52 | 125195 | 38477 | 50441400 |
Clostridium difficile colitis | 11.76 | 9.92 | 16 | 125231 | 17726 | 50462151 |
Blood pressure orthostatic abnormal | 11.73 | 9.92 | 3 | 125244 | 6 | 50479871 |
Pain in jaw | 11.72 | 9.92 | 52 | 125195 | 38376 | 50441501 |
Distractibility | 11.72 | 9.92 | 9 | 125238 | 398 | 50479479 |
Ulcer | 11.68 | 9.92 | 20 | 125227 | 20180 | 50459697 |
Anaphylactic shock | 11.61 | 9.92 | 20 | 125227 | 20135 | 50459742 |
Restlessness | 11.60 | 9.92 | 104 | 125143 | 25069 | 50454808 |
Middle insomnia | 11.58 | 9.92 | 52 | 125195 | 9869 | 50470008 |
Tri-iodothyronine free decreased | 11.52 | 9.92 | 8 | 125239 | 302 | 50479575 |
Clostridium difficile infection | 11.48 | 9.92 | 29 | 125218 | 25410 | 50454467 |
Partner stress | 11.48 | 9.92 | 8 | 125239 | 304 | 50479573 |
Impulsive behaviour | 11.44 | 9.92 | 16 | 125231 | 1442 | 50478435 |
Nystagmus | 11.43 | 9.92 | 35 | 125212 | 5526 | 50474351 |
Homeless | 11.40 | 9.92 | 5 | 125242 | 74 | 50479803 |
Drug screen false positive | 11.37 | 9.92 | 12 | 125235 | 807 | 50479070 |
Injection site mass | 11.31 | 9.92 | 72 | 125175 | 15608 | 50464269 |
Disorientation | 11.31 | 9.92 | 136 | 125111 | 35348 | 50444529 |
Diverticulitis | 11.31 | 9.92 | 43 | 125204 | 33139 | 50446738 |
Bankruptcy | 11.31 | 9.92 | 4 | 125243 | 32 | 50479845 |
Incorrect route of product administration | 11.25 | 9.92 | 82 | 125165 | 18584 | 50461293 |
Rheumatoid nodule | 11.24 | 9.92 | 9 | 125238 | 12726 | 50467151 |
Electrocardiogram QRS complex shortened | 11.21 | 9.92 | 9 | 125238 | 425 | 50479452 |
Therapeutic product effect decreased | 11.14 | 9.92 | 254 | 124993 | 135796 | 50344081 |
Priapism | 11.11 | 9.92 | 5 | 125242 | 79 | 50479798 |
Hepatic encephalopathy | 11.04 | 9.92 | 5 | 125242 | 9631 | 50470246 |
Basal cell carcinoma | 11.04 | 9.92 | 26 | 125221 | 23330 | 50456547 |
Gaze palsy | 11.02 | 9.92 | 15 | 125232 | 1318 | 50478559 |
Abnormal sleep-related event | 10.96 | 9.92 | 11 | 125236 | 697 | 50479180 |
Pancreatitis acute | 10.86 | 9.92 | 27 | 125220 | 23785 | 50456092 |
Orthostatic hypotension | 10.85 | 9.92 | 37 | 125210 | 29444 | 50450433 |
Hyperphagia | 10.83 | 9.92 | 16 | 125231 | 1516 | 50478361 |
Tubulointerstitial nephritis | 10.83 | 9.92 | 13 | 125234 | 15198 | 50464679 |
Panic disorder | 10.81 | 9.92 | 20 | 125227 | 2283 | 50477594 |
Diabetes mellitus | 10.80 | 9.92 | 176 | 125071 | 48857 | 50431020 |
Metastases to lung | 10.76 | 9.92 | 7 | 125240 | 11013 | 50468864 |
Convulsive threshold lowered | 10.75 | 9.92 | 8 | 125239 | 337 | 50479540 |
Diabetes mellitus inadequate control | 10.74 | 9.92 | 10 | 125237 | 13135 | 50466742 |
Vocal cord thickening | 10.71 | 9.92 | 4 | 125243 | 38 | 50479839 |
Rectal haemorrhage | 10.69 | 9.92 | 54 | 125193 | 38504 | 50441373 |
Device related infection | 10.69 | 9.92 | 22 | 125225 | 20713 | 50459164 |
Infusion site discomfort | 10.68 | 9.92 | 12 | 125235 | 866 | 50479011 |
Live birth | 10.67 | 9.92 | 15 | 125232 | 16393 | 50463484 |
Haemophagocytic lymphohistiocytosis | 10.67 | 9.92 | 4 | 125243 | 8629 | 50471248 |
Blood potassium increased | 10.66 | 9.92 | 15 | 125232 | 16383 | 50463494 |
Intermenstrual bleeding | 10.56 | 9.92 | 39 | 125208 | 6775 | 50473102 |
Serum sickness-like reaction | 10.56 | 9.92 | 9 | 125238 | 462 | 50479415 |
Poor quality sleep | 10.54 | 9.92 | 74 | 125173 | 16572 | 50463305 |
Formication | 10.54 | 9.92 | 26 | 125221 | 3620 | 50476257 |
Hangover | 10.54 | 9.92 | 15 | 125232 | 1374 | 50478503 |
Accidental poisoning | 10.53 | 9.92 | 10 | 125237 | 592 | 50479285 |
Depressive symptom | 10.53 | 9.92 | 24 | 125223 | 3176 | 50476701 |
Blood pressure systolic abnormal | 10.52 | 9.92 | 3 | 125244 | 7703 | 50472174 |
Drug-induced liver injury | 10.51 | 9.92 | 35 | 125212 | 28060 | 50451817 |
Inadequate analgesia | 10.51 | 9.92 | 21 | 125226 | 2537 | 50477340 |
Psychotic disorder | 10.51 | 9.92 | 91 | 125156 | 21721 | 50458156 |
Postmortem blood drug level abnormal | 10.49 | 9.92 | 8 | 125239 | 350 | 50479527 |
Ankle operation | 10.43 | 9.92 | 14 | 125233 | 1213 | 50478664 |
Mouth ulceration | 10.43 | 9.92 | 35 | 125212 | 27989 | 50451888 |
Drug titration error | 10.42 | 9.92 | 10 | 125237 | 600 | 50479277 |
Plasma cell myeloma | 10.41 | 9.92 | 41 | 125206 | 31281 | 50448596 |
Heavy menstrual bleeding | 10.39 | 9.92 | 70 | 125177 | 15467 | 50464410 |
Multiple fractures | 10.38 | 9.92 | 38 | 125209 | 6573 | 50473304 |
Product solubility abnormal | 10.38 | 9.92 | 11 | 125236 | 743 | 50479134 |
Tearfulness | 10.35 | 9.92 | 26 | 125221 | 3661 | 50476216 |
Pulmonary oedema | 10.18 | 9.92 | 75 | 125172 | 48863 | 50431014 |
Embedded device | 10.15 | 9.92 | 22 | 125225 | 2815 | 50477062 |
Blood triglycerides increased | 10.14 | 9.92 | 55 | 125192 | 11257 | 50468620 |
Haemodialysis | 10.12 | 9.92 | 4 | 125243 | 8358 | 50471519 |
Pineal gland cyst | 10.02 | 9.92 | 3 | 125244 | 13 | 50479864 |
Dry mouth | 10.01 | 9.92 | 195 | 125052 | 55983 | 50423894 |
Pneumothorax | 9.98 | 9.92 | 12 | 125235 | 14022 | 50465855 |
Sputum discoloured | 9.97 | 9.92 | 62 | 125185 | 13333 | 50466544 |
Drug ineffective | 9.93 | 9.92 | 1832 | 123415 | 817501 | 49662376 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Completed suicide | 2117.34 | 11.18 | 1508 | 48510 | 88738 | 29435771 |
Depression | 1069.80 | 11.18 | 990 | 49028 | 84157 | 29440352 |
Toxicity to various agents | 600.10 | 11.18 | 1060 | 48958 | 172601 | 29351908 |
Serotonin syndrome | 467.29 | 11.18 | 318 | 49700 | 17194 | 29507315 |
Drug interaction | 426.59 | 11.18 | 992 | 49026 | 196393 | 29328116 |
Intentional overdose | 335.17 | 11.18 | 368 | 49650 | 38160 | 29486349 |
Suicidal ideation | 304.38 | 11.18 | 333 | 49685 | 34383 | 29490126 |
Overdose | 298.96 | 11.18 | 506 | 49512 | 79313 | 29445196 |
Anxiety | 242.17 | 11.18 | 480 | 49538 | 84885 | 29439624 |
Drug abuse | 227.55 | 11.18 | 450 | 49568 | 79433 | 29445076 |
Seizure | 223.62 | 11.18 | 489 | 49529 | 92634 | 29431875 |
Cardio-respiratory arrest | 190.83 | 11.18 | 322 | 49696 | 50279 | 29474230 |
Loss of personal independence in daily activities | 149.04 | 11.18 | 199 | 49819 | 25241 | 29499268 |
Status epilepticus | 145.55 | 11.18 | 131 | 49887 | 10663 | 29513846 |
Electrocardiogram QRS complex prolonged | 144.95 | 11.18 | 89 | 49929 | 4021 | 29520488 |
Febrile neutropenia | 139.64 | 11.18 | 14 | 50004 | 112226 | 29412283 |
Generalised tonic-clonic seizure | 125.02 | 11.18 | 158 | 49860 | 18981 | 29505528 |
Hyperreflexia | 121.28 | 11.18 | 69 | 49949 | 2703 | 29521806 |
Anaemia | 119.33 | 11.18 | 99 | 49919 | 200852 | 29323657 |
Acute kidney injury | 115.43 | 11.18 | 169 | 49849 | 265098 | 29259411 |
Suicide attempt | 115.39 | 11.18 | 207 | 49811 | 33903 | 29490606 |
Thrombocytopenia | 111.97 | 11.18 | 44 | 49974 | 134779 | 29389730 |
Tremor | 105.28 | 11.18 | 318 | 49700 | 73220 | 29451289 |
Psychiatric decompensation | 104.48 | 11.18 | 51 | 49967 | 1453 | 29523056 |
Depression suicidal | 101.70 | 11.18 | 48 | 49970 | 1267 | 29523242 |
Poisoning | 100.13 | 11.18 | 103 | 49915 | 9890 | 29514619 |
Paranoia | 99.33 | 11.18 | 102 | 49916 | 9775 | 29514734 |
Distributive shock | 98.47 | 11.18 | 43 | 49975 | 942 | 29523567 |
Suspected suicide | 93.13 | 11.18 | 67 | 49951 | 3953 | 29520556 |
Tearfulness | 91.75 | 11.18 | 48 | 49970 | 1588 | 29522921 |
Insomnia | 85.99 | 11.18 | 337 | 49681 | 88424 | 29436085 |
Pyrexia | 84.83 | 11.18 | 230 | 49788 | 287392 | 29237117 |
Agitation | 82.17 | 11.18 | 231 | 49787 | 51073 | 29473436 |
Sepsis | 81.32 | 11.18 | 73 | 49945 | 142609 | 29381900 |
Psychotic disorder | 81.28 | 11.18 | 133 | 49885 | 20221 | 29504288 |
Product substitution issue | 75.15 | 11.18 | 85 | 49933 | 9087 | 29515422 |
Neutropenia | 73.13 | 11.18 | 69 | 49949 | 131642 | 29392867 |
Malignant neoplasm progression | 72.16 | 11.18 | 18 | 50000 | 73841 | 29450668 |
Sexual dysfunction | 71.44 | 11.18 | 67 | 49951 | 5747 | 29518762 |
Pneumonia | 67.33 | 11.18 | 296 | 49722 | 319876 | 29204633 |
Postmortem blood drug level increased | 67.08 | 11.18 | 22 | 49996 | 209 | 29524300 |
General physical health deterioration | 65.61 | 11.18 | 47 | 49971 | 102810 | 29421699 |
Cardiogenic shock | 64.28 | 11.18 | 116 | 49902 | 19074 | 29505435 |
Platelet count decreased | 63.98 | 11.18 | 50 | 49968 | 104622 | 29419887 |
Pancytopenia | 62.90 | 11.18 | 31 | 49987 | 83137 | 29441372 |
Septic shock | 59.66 | 11.18 | 16 | 50002 | 62544 | 29461965 |
Therapeutic response unexpected | 59.09 | 11.18 | 73 | 49945 | 8565 | 29515944 |
Interstitial lung disease | 58.48 | 11.18 | 13 | 50005 | 57705 | 29466804 |
Respiratory arrest | 57.72 | 11.18 | 132 | 49886 | 25701 | 29498808 |
Irritability | 57.22 | 11.18 | 120 | 49898 | 22032 | 29502477 |
Exposure via ingestion | 57.01 | 11.18 | 38 | 49980 | 1980 | 29522529 |
Hyperkalaemia | 56.14 | 11.18 | 17 | 50001 | 61375 | 29463134 |
Anger | 54.49 | 11.18 | 79 | 49939 | 10811 | 29513698 |
Depressive symptom | 52.56 | 11.18 | 34 | 49984 | 1683 | 29522826 |
Tardive dyskinesia | 52.32 | 11.18 | 54 | 49964 | 5204 | 29519305 |
Vein of Galen aneurysmal malformation | 51.62 | 11.18 | 11 | 50007 | 11 | 29524498 |
Depressed mood | 50.78 | 11.18 | 96 | 49922 | 16352 | 29508157 |
Renal impairment | 50.77 | 11.18 | 38 | 49980 | 81295 | 29443214 |
Memory impairment | 49.59 | 11.18 | 155 | 49863 | 36315 | 29488194 |
Erectile dysfunction | 49.39 | 11.18 | 100 | 49918 | 17909 | 29506600 |
Dyspnoea | 48.90 | 11.18 | 338 | 49680 | 326394 | 29198115 |
Major depression | 48.67 | 11.18 | 45 | 49973 | 3790 | 29520719 |
Pupil fixed | 48.06 | 11.18 | 32 | 49986 | 1664 | 29522845 |
Cardiac arrest | 47.05 | 11.18 | 276 | 49742 | 85315 | 29439194 |
Autonomic nervous system imbalance | 46.96 | 11.18 | 36 | 49982 | 2340 | 29522169 |
C-reactive protein increased | 44.77 | 11.18 | 10 | 50008 | 44253 | 29480256 |
Feeling abnormal | 44.26 | 11.18 | 196 | 49822 | 54249 | 29470260 |
Diarrhoea | 44.14 | 11.18 | 356 | 49662 | 332342 | 29192167 |
Haemoglobin decreased | 44.14 | 11.18 | 72 | 49946 | 108303 | 29416206 |
Cardiac failure | 43.42 | 11.18 | 42 | 49976 | 79245 | 29445264 |
Electrocardiogram QT prolonged | 43.21 | 11.18 | 147 | 49871 | 35990 | 29488519 |
Clonus | 42.61 | 11.18 | 34 | 49984 | 2344 | 29522165 |
Libido decreased | 42.51 | 11.18 | 44 | 49974 | 4254 | 29520255 |
Disease progression | 41.91 | 11.18 | 46 | 49972 | 81870 | 29442639 |
Intentional product misuse | 41.44 | 11.18 | 141 | 49877 | 34520 | 29489989 |
Renal failure | 41.04 | 11.18 | 87 | 49931 | 118512 | 29405997 |
Rhinitis perennial | 40.96 | 11.18 | 15 | 50003 | 203 | 29524306 |
Disturbance in attention | 40.89 | 11.18 | 103 | 49915 | 21321 | 29503188 |
Product residue present | 40.65 | 11.18 | 34 | 49984 | 2505 | 29522004 |
Maternal drugs affecting foetus | 40.58 | 11.18 | 41 | 49977 | 3852 | 29520657 |
Drug withdrawal syndrome | 40.28 | 11.18 | 92 | 49926 | 17892 | 29506617 |
Euphoric mood | 40.01 | 11.18 | 45 | 49973 | 4780 | 29519729 |
Psychomotor skills impaired | 39.26 | 11.18 | 34 | 49984 | 2627 | 29521882 |
Myoclonus | 39.02 | 11.18 | 76 | 49942 | 13233 | 29511276 |
Pleural effusion | 38.33 | 11.18 | 39 | 49979 | 71869 | 29452640 |
Depersonalisation/derealisation disorder | 38.26 | 11.18 | 19 | 49999 | 562 | 29523947 |
Panic attack | 38.21 | 11.18 | 58 | 49960 | 8268 | 29516241 |
Basilar artery occlusion | 37.38 | 11.18 | 11 | 50007 | 70 | 29524439 |
Electrocardiogram PR prolongation | 36.91 | 11.18 | 20 | 49998 | 711 | 29523798 |
Hyponatraemic coma | 36.80 | 11.18 | 9 | 50009 | 24 | 29524485 |
Multiple organ dysfunction syndrome | 36.25 | 11.18 | 32 | 49986 | 63084 | 29461425 |
Hallucination, visual | 36.08 | 11.18 | 79 | 49939 | 14936 | 29509573 |
Neonatal toxicity | 36.03 | 11.18 | 9 | 50009 | 27 | 29524482 |
Mucosal inflammation | 34.34 | 11.18 | 6 | 50012 | 31589 | 29492920 |
Drug reaction with eosinophilia and systemic symptoms | 33.48 | 11.18 | 4 | 50014 | 27988 | 29496521 |
Dysphoria | 33.47 | 11.18 | 28 | 49990 | 2064 | 29522445 |
Mood swings | 32.55 | 11.18 | 50 | 49968 | 7201 | 29517308 |
Blood creatinine increased | 32.39 | 11.18 | 59 | 49959 | 85043 | 29439466 |
Vasoplegia syndrome | 32.36 | 11.18 | 24 | 49994 | 1484 | 29523025 |
Sedation | 31.47 | 11.18 | 82 | 49936 | 17323 | 29507186 |
Lower respiratory tract infection | 31.17 | 11.18 | 4 | 50014 | 26498 | 29498011 |
Bradyphrenia | 31.08 | 11.18 | 37 | 49981 | 4177 | 29520332 |
Off label use | 30.80 | 11.18 | 343 | 49675 | 300457 | 29224052 |
Tinnitus | 30.77 | 11.18 | 76 | 49942 | 15538 | 29508971 |
Transposition of the great vessels | 30.17 | 11.18 | 15 | 50003 | 445 | 29524064 |
Mood altered | 29.70 | 11.18 | 51 | 49967 | 8060 | 29516449 |
Hypokalaemia | 29.38 | 11.18 | 25 | 49993 | 50178 | 29474331 |
Leukopenia | 29.34 | 11.18 | 30 | 49988 | 55173 | 29469336 |
Intentional self-injury | 29.30 | 11.18 | 65 | 49953 | 12396 | 29512113 |
Talipes | 28.70 | 11.18 | 24 | 49994 | 1768 | 29522741 |
Ascites | 28.66 | 11.18 | 13 | 50005 | 36606 | 29487903 |
Encephalopathy neonatal | 28.64 | 11.18 | 8 | 50010 | 41 | 29524468 |
Mania | 28.53 | 11.18 | 52 | 49966 | 8611 | 29515898 |
Respiratory failure | 28.25 | 11.18 | 78 | 49940 | 97053 | 29427456 |
Melaena | 27.84 | 11.18 | 9 | 50009 | 31167 | 29493342 |
Infection | 27.63 | 11.18 | 55 | 49963 | 76696 | 29447813 |
Incorrect route of product administration | 27.29 | 11.18 | 58 | 49960 | 10743 | 29513766 |
Hallucination | 27.05 | 11.18 | 148 | 49870 | 44564 | 29479945 |
Cholestasis | 26.52 | 11.18 | 4 | 50014 | 23458 | 29501051 |
Dry mouth | 26.37 | 11.18 | 89 | 49929 | 21695 | 29502814 |
Hepatic function abnormal | 26.26 | 11.18 | 17 | 50001 | 39242 | 29485267 |
Cytomegalovirus infection | 26.14 | 11.18 | 4 | 50014 | 23211 | 29501298 |
Abnormal behaviour | 25.83 | 11.18 | 92 | 49926 | 23035 | 29501474 |
Delusion | 25.81 | 11.18 | 58 | 49960 | 11158 | 29513351 |
White blood cell count decreased | 25.72 | 11.18 | 65 | 49953 | 83297 | 29441212 |
Apathy | 25.54 | 11.18 | 41 | 49977 | 6130 | 29518379 |
Infusion related reaction | 25.50 | 11.18 | 22 | 49996 | 43864 | 29480645 |
Gastrointestinal haemorrhage | 25.33 | 11.18 | 61 | 49957 | 79472 | 29445037 |
Tachycardia | 25.25 | 11.18 | 209 | 49809 | 72201 | 29452308 |
Aggression | 25.22 | 11.18 | 123 | 49895 | 35418 | 29489091 |
Erythema | 24.87 | 11.18 | 57 | 49961 | 75549 | 29448960 |
Emotional distress | 24.65 | 11.18 | 65 | 49953 | 13830 | 29510679 |
Feelings of worthlessness | 24.58 | 11.18 | 11 | 50007 | 256 | 29524253 |
Eosinophilia | 24.54 | 11.18 | 4 | 50014 | 22157 | 29502352 |
Bone marrow failure | 24.37 | 11.18 | 8 | 50010 | 27441 | 29497068 |
Substance use disorder | 24.15 | 11.18 | 11 | 50007 | 267 | 29524242 |
Adjustment disorder | 23.91 | 11.18 | 17 | 50001 | 984 | 29523525 |
Weight increased | 23.46 | 11.18 | 215 | 49803 | 76452 | 29448057 |
Cerebral haemorrhage | 23.31 | 11.18 | 12 | 50006 | 31414 | 29493095 |
Pelvic abscess | 23.26 | 11.18 | 16 | 50002 | 878 | 29523631 |
Restless legs syndrome | 23.10 | 11.18 | 42 | 49976 | 6942 | 29517567 |
Sleep disorder | 23.08 | 11.18 | 92 | 49926 | 24294 | 29500215 |
Drug dependence | 23.04 | 11.18 | 83 | 49935 | 20898 | 29503611 |
Hypomania | 22.84 | 11.18 | 23 | 49995 | 2152 | 29522357 |
Abdominal pain | 22.72 | 11.18 | 135 | 49883 | 135222 | 29389287 |
Malaise | 22.37 | 11.18 | 168 | 49850 | 159434 | 29365075 |
Stomatitis | 22.30 | 11.18 | 18 | 50000 | 37095 | 29487414 |
Nightmare | 21.89 | 11.18 | 55 | 49963 | 11362 | 29513147 |
Atrial fibrillation | 21.88 | 11.18 | 98 | 49920 | 105548 | 29418961 |
Marital problem | 21.78 | 11.18 | 7 | 50011 | 62 | 29524447 |
Gamma-glutamyltransferase increased | 21.70 | 11.18 | 9 | 50009 | 26728 | 29497781 |
Rheumatoid arthritis | 21.40 | 11.18 | 14 | 50004 | 32138 | 29492371 |
Mental status changes | 21.39 | 11.18 | 116 | 49902 | 34811 | 29489698 |
Persecutory delusion | 21.32 | 11.18 | 22 | 49996 | 2119 | 29522390 |
Product complaint | 21.14 | 11.18 | 35 | 49983 | 5370 | 29519139 |
Dehydration | 21.12 | 11.18 | 111 | 49907 | 114637 | 29409872 |
Hallucination, tactile | 20.98 | 11.18 | 10 | 50008 | 270 | 29524239 |
Dyskinesia | 20.88 | 11.18 | 78 | 49940 | 19983 | 29504526 |
Unresponsive to stimuli | 20.81 | 11.18 | 91 | 49927 | 25035 | 29499474 |
Orgasm abnormal | 20.80 | 11.18 | 8 | 50010 | 125 | 29524384 |
Alcoholism | 20.68 | 11.18 | 24 | 49994 | 2637 | 29521872 |
Jaundice | 20.55 | 11.18 | 12 | 50006 | 29284 | 29495225 |
Gun shot wound | 20.49 | 11.18 | 16 | 50002 | 1069 | 29523440 |
Pre-existing condition improved | 20.39 | 11.18 | 22 | 49996 | 2231 | 29522278 |
Lupus-like syndrome | 20.31 | 11.18 | 22 | 49996 | 2240 | 29522269 |
Hallucination, auditory | 20.30 | 11.18 | 48 | 49970 | 9545 | 29514964 |
Amnesia | 20.30 | 11.18 | 84 | 49934 | 22559 | 29501950 |
Haematuria | 20.22 | 11.18 | 27 | 49991 | 44112 | 29480397 |
Substance abuse | 20.19 | 11.18 | 39 | 49979 | 6748 | 29517761 |
Dysarthria | 19.84 | 11.18 | 104 | 49914 | 30807 | 29493702 |
Treatment failure | 19.71 | 11.18 | 20 | 49998 | 36919 | 29487590 |
Decreased interest | 19.56 | 11.18 | 21 | 49997 | 2117 | 29522392 |
Accidental poisoning | 19.46 | 11.18 | 12 | 50006 | 546 | 29523963 |
Thinking abnormal | 19.27 | 11.18 | 33 | 49985 | 5203 | 29519306 |
Disseminated intravascular coagulation | 19.25 | 11.18 | 5 | 50013 | 19975 | 29504534 |
Road traffic accident | 19.21 | 11.18 | 64 | 49954 | 15497 | 29509012 |
Ideas of reference | 19.20 | 11.18 | 6 | 50012 | 48 | 29524461 |
Oedema peripheral | 19.16 | 11.18 | 100 | 49918 | 103457 | 29421052 |
Akathisia | 19.15 | 11.18 | 38 | 49980 | 6704 | 29517805 |
Withdrawal syndrome | 19.07 | 11.18 | 51 | 49967 | 10941 | 29513568 |
Atrial septal defect | 18.97 | 11.18 | 38 | 49980 | 6751 | 29517758 |
Crying | 18.75 | 11.18 | 33 | 49985 | 5318 | 29519191 |
Psychomotor retardation | 18.53 | 11.18 | 24 | 49994 | 2952 | 29521557 |
Injection site reaction | 18.50 | 11.18 | 51 | 49967 | 11137 | 29513372 |
Obsessive-compulsive disorder | 18.39 | 11.18 | 30 | 49988 | 4546 | 29519963 |
Product use in unapproved indication | 18.34 | 11.18 | 80 | 49938 | 86795 | 29437714 |
Oxygen saturation decreased | 18.14 | 11.18 | 30 | 49988 | 44907 | 29479602 |
Disorientation | 18.05 | 11.18 | 98 | 49920 | 29417 | 29495092 |
Vomiting | 17.93 | 11.18 | 252 | 49766 | 212008 | 29312501 |
Lung disorder | 17.90 | 11.18 | 15 | 50003 | 30347 | 29494162 |
Drug resistance | 17.89 | 11.18 | 7 | 50011 | 21533 | 29502976 |
Delirium | 17.85 | 11.18 | 121 | 49897 | 39276 | 29485233 |
Dissociation | 17.83 | 11.18 | 15 | 50003 | 1114 | 29523395 |
Feeling jittery | 17.66 | 11.18 | 26 | 49992 | 3607 | 29520902 |
International normalised ratio increased | 17.56 | 11.18 | 30 | 49988 | 44342 | 29480167 |
Drug withdrawal syndrome neonatal | 17.52 | 11.18 | 25 | 49993 | 3370 | 29521139 |
Blood testosterone decreased | 17.50 | 11.18 | 27 | 49991 | 3903 | 29520606 |
Hepatocellular injury | 17.49 | 11.18 | 7 | 50011 | 21236 | 29503273 |
Liver disorder | 17.25 | 11.18 | 13 | 50005 | 27736 | 29496773 |
Dependence | 16.86 | 11.18 | 14 | 50004 | 1021 | 29523488 |
Vision blurred | 16.80 | 11.18 | 121 | 49897 | 40055 | 29484454 |
Neutrophil count decreased | 16.75 | 11.18 | 30 | 49988 | 43537 | 29480972 |
Cutaneous lupus erythematosus | 16.56 | 11.18 | 12 | 50006 | 716 | 29523793 |
Tongue biting | 16.48 | 11.18 | 12 | 50006 | 721 | 29523788 |
Poor feeding infant | 16.44 | 11.18 | 10 | 50008 | 444 | 29524065 |
Postictal state | 16.38 | 11.18 | 12 | 50006 | 728 | 29523781 |
Agranulocytosis | 16.26 | 11.18 | 7 | 50011 | 20333 | 29504176 |
Product quality issue | 15.88 | 11.18 | 61 | 49957 | 15834 | 29508675 |
Hyperhidrosis | 15.87 | 11.18 | 173 | 49845 | 64367 | 29460142 |
Loss of employment | 15.79 | 11.18 | 10 | 50008 | 477 | 29524032 |
Mydriasis | 15.75 | 11.18 | 33 | 49985 | 6052 | 29518457 |
Hunger | 15.53 | 11.18 | 15 | 50003 | 1334 | 29523175 |
COVID-19 | 15.52 | 11.18 | 23 | 49995 | 35991 | 29488518 |
Decreased appetite | 15.51 | 11.18 | 164 | 49854 | 145178 | 29379331 |
Suicidal behaviour | 15.38 | 11.18 | 15 | 50003 | 1350 | 29523159 |
Abulia | 15.35 | 11.18 | 10 | 50008 | 501 | 29524008 |
Foetal exposure during pregnancy | 15.33 | 11.18 | 104 | 49914 | 33763 | 29490746 |
Hostility | 15.32 | 11.18 | 12 | 50006 | 805 | 29523704 |
Sinus tachycardia | 15.19 | 11.18 | 58 | 49960 | 15011 | 29509498 |
Blood triglycerides increased | 15.15 | 11.18 | 52 | 49966 | 12782 | 29511727 |
Loss of libido | 15.05 | 11.18 | 19 | 49999 | 2277 | 29522232 |
Sleep apnoea syndrome | 14.77 | 11.18 | 64 | 49954 | 17535 | 29506974 |
Hypoplastic right heart syndrome | 14.75 | 11.18 | 4 | 50014 | 18 | 29524491 |
Depressed level of consciousness | 14.72 | 11.18 | 110 | 49908 | 36832 | 29487677 |
Persistent depressive disorder | 14.67 | 11.18 | 8 | 50010 | 288 | 29524221 |
Hypoglycaemia | 14.67 | 11.18 | 38 | 49980 | 48308 | 29476201 |
Injection site mass | 14.61 | 11.18 | 30 | 49988 | 5425 | 29519084 |
Balance disorder | 14.59 | 11.18 | 108 | 49910 | 36062 | 29488447 |
Myelodysplastic syndrome | 14.43 | 11.18 | 6 | 50012 | 17788 | 29506721 |
Colitis | 14.42 | 11.18 | 19 | 49999 | 31229 | 29493280 |
Lactic acidosis | 14.37 | 11.18 | 18 | 50000 | 30229 | 29494280 |
Acute myeloid leukaemia | 14.33 | 11.18 | 5 | 50013 | 16508 | 29508001 |
Multiple sclerosis | 14.23 | 11.18 | 30 | 49988 | 5524 | 29518985 |
Tubulointerstitial nephritis | 14.22 | 11.18 | 6 | 50012 | 17637 | 29506872 |
Hallucinations, mixed | 14.18 | 11.18 | 19 | 49999 | 2414 | 29522095 |
Toxic optic neuropathy | 14.15 | 11.18 | 11 | 50007 | 730 | 29523779 |
Dissociative disorder | 14.13 | 11.18 | 7 | 50011 | 206 | 29524303 |
Clonic convulsion | 14.12 | 11.18 | 10 | 50008 | 575 | 29523934 |
Slow speech | 14.12 | 11.18 | 12 | 50006 | 904 | 29523605 |
Binge drinking | 14.08 | 11.18 | 3 | 50015 | 3 | 29524506 |
Upper gastrointestinal haemorrhage | 13.97 | 11.18 | 10 | 50008 | 21904 | 29502605 |
Urine amphetamine positive | 13.94 | 11.18 | 4 | 50014 | 23 | 29524486 |
Product solubility abnormal | 13.83 | 11.18 | 9 | 50009 | 450 | 29524059 |
Double inlet left ventricle | 13.79 | 11.18 | 4 | 50014 | 24 | 29524485 |
Bipolar disorder | 13.79 | 11.18 | 22 | 49996 | 3273 | 29521236 |
Prescribed overdose | 13.78 | 11.18 | 39 | 49979 | 8644 | 29515865 |
Testicular pain | 13.73 | 11.18 | 19 | 49999 | 2490 | 29522019 |
Hepatic failure | 13.70 | 11.18 | 20 | 49998 | 31492 | 29493017 |
Priapism | 13.61 | 11.18 | 26 | 49992 | 4462 | 29520047 |
Blood pressure decreased | 13.60 | 11.18 | 36 | 49982 | 45441 | 29479068 |
Extra dose administered | 13.50 | 11.18 | 21 | 49997 | 3056 | 29521453 |
Migraine | 13.50 | 11.18 | 49 | 49969 | 12381 | 29512128 |
Obesity | 13.47 | 11.18 | 42 | 49976 | 9821 | 29514688 |
Energy increased | 13.38 | 11.18 | 13 | 50005 | 1165 | 29523344 |
Ventricular hypoplasia | 13.37 | 11.18 | 5 | 50013 | 72 | 29524437 |
Blood cholesterol increased | 13.31 | 11.18 | 57 | 49961 | 15538 | 29508971 |
Gastrooesophageal reflux disease | 13.25 | 11.18 | 95 | 49923 | 31401 | 29493108 |
Cytokine release syndrome | 13.19 | 11.18 | 3 | 50015 | 13116 | 29511393 |
Restlessness | 13.18 | 11.18 | 73 | 49945 | 22072 | 29502437 |
Psychomotor hyperactivity | 13.15 | 11.18 | 37 | 49981 | 8176 | 29516333 |
Rash maculo-papular | 13.13 | 11.18 | 13 | 50005 | 24276 | 29500233 |
Emotional disorder | 13.06 | 11.18 | 27 | 49991 | 4904 | 29519605 |
Pulmonary fibrosis | 13.05 | 11.18 | 5 | 50013 | 15577 | 29508932 |
Sperm concentration decreased | 13.05 | 11.18 | 6 | 50012 | 149 | 29524360 |
Cognitive disorder | 13.03 | 11.18 | 76 | 49942 | 23423 | 29501086 |
Pneumonitis | 13.00 | 11.18 | 17 | 50001 | 28027 | 29496482 |
Drug tolerance | 12.84 | 11.18 | 17 | 50001 | 2136 | 29522373 |
Pulmonary oedema | 12.65 | 11.18 | 34 | 49984 | 42701 | 29481808 |
Epistaxis | 12.57 | 11.18 | 45 | 49973 | 51659 | 29472850 |
Brugada syndrome | 12.51 | 11.18 | 10 | 50008 | 691 | 29523818 |
Inflammation | 12.48 | 11.18 | 12 | 50006 | 22716 | 29501793 |
Respiratory distress | 12.43 | 11.18 | 22 | 49996 | 32084 | 29492425 |
Univentricular heart | 12.39 | 11.18 | 4 | 50014 | 36 | 29524473 |
Symptom masked | 12.31 | 11.18 | 9 | 50009 | 544 | 29523965 |
Psoriasis | 12.30 | 11.18 | 95 | 49923 | 32132 | 29492377 |
Congenital aortic stenosis | 12.30 | 11.18 | 5 | 50013 | 91 | 29524418 |
Tongue spasm | 12.01 | 11.18 | 4 | 50014 | 40 | 29524469 |
Cough | 11.94 | 11.18 | 147 | 49871 | 126580 | 29397929 |
Blood lactate dehydrogenase increased | 11.94 | 11.18 | 9 | 50009 | 19200 | 29505309 |
Cerebral disorder | 11.92 | 11.18 | 17 | 50001 | 2291 | 29522218 |
Gambling disorder | 11.90 | 11.18 | 14 | 50004 | 1561 | 29522948 |
Pericardial effusion | 11.87 | 11.18 | 11 | 50007 | 21197 | 29503312 |
Life expectancy shortened | 11.84 | 11.18 | 4 | 50014 | 42 | 29524467 |
Antidepressant drug level increased | 11.82 | 11.18 | 5 | 50013 | 101 | 29524408 |
Lymphadenopathy | 11.80 | 11.18 | 15 | 50003 | 25034 | 29499475 |
Nervousness | 11.80 | 11.18 | 44 | 49974 | 11262 | 29513247 |
Haemorrhage | 11.79 | 11.18 | 38 | 49980 | 45034 | 29479475 |
Haemoptysis | 11.77 | 11.18 | 21 | 49997 | 30529 | 29493980 |
Male orgasmic disorder | 11.73 | 11.18 | 5 | 50013 | 103 | 29524406 |
Ejaculation disorder | 11.59 | 11.18 | 11 | 50007 | 957 | 29523552 |
Genital discomfort | 11.59 | 11.18 | 4 | 50014 | 45 | 29524464 |
Congenital tricuspid valve atresia | 11.51 | 11.18 | 5 | 50013 | 108 | 29524401 |
Drug screen positive | 11.50 | 11.18 | 22 | 49996 | 3779 | 29520730 |
Inadequate analgesia | 11.49 | 11.18 | 18 | 50000 | 2636 | 29521873 |
Social avoidant behaviour | 11.44 | 11.18 | 19 | 49999 | 2923 | 29521586 |
Inability to afford medication | 11.36 | 11.18 | 11 | 50007 | 981 | 29523528 |
Metastases to liver | 11.36 | 11.18 | 3 | 50015 | 11853 | 29512656 |
Neuropathy peripheral | 11.29 | 11.18 | 72 | 49946 | 70955 | 29453554 |
Lethargy | 11.29 | 11.18 | 105 | 49913 | 37475 | 29487034 |
Intercepted medication error | 11.24 | 11.18 | 8 | 50010 | 464 | 29524045 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Completed suicide | 5384.45 | 10.31 | 4190 | 135031 | 220224 | 64139287 |
Toxicity to various agents | 1422.07 | 10.31 | 2690 | 136531 | 360823 | 63998688 |
Intentional overdose | 838.93 | 10.31 | 1002 | 138219 | 88942 | 64270569 |
Depression | 838.18 | 10.31 | 1454 | 137767 | 181837 | 64177674 |
Overdose | 750.53 | 10.31 | 1282 | 137939 | 158284 | 64201227 |
Serotonin syndrome | 693.36 | 10.31 | 617 | 138604 | 38665 | 64320846 |
Seizure | 576.79 | 10.31 | 1175 | 138046 | 165717 | 64193794 |
Cardio-respiratory arrest | 534.34 | 10.31 | 844 | 138377 | 97549 | 64261962 |
Generalised tonic-clonic seizure | 511.28 | 10.31 | 525 | 138696 | 39332 | 64320179 |
Anxiety | 462.78 | 10.31 | 1212 | 138009 | 201437 | 64158074 |
Suicidal ideation | 453.35 | 10.31 | 635 | 138586 | 65907 | 64293604 |
Electrocardiogram QRS complex prolonged | 409.77 | 10.31 | 253 | 138968 | 8991 | 64350520 |
Suspected suicide | 389.07 | 10.31 | 239 | 138982 | 8415 | 64351096 |
Status epilepticus | 373.68 | 10.31 | 336 | 138885 | 21327 | 64338184 |
Suicide attempt | 286.33 | 10.31 | 534 | 138687 | 70473 | 64289038 |
Cardiac arrest | 265.35 | 10.31 | 833 | 138388 | 153231 | 64206280 |
Acute kidney injury | 256.31 | 10.31 | 358 | 138863 | 448882 | 63910629 |
Drug abuse | 255.45 | 10.31 | 745 | 138476 | 131629 | 64227882 |
Anaemia | 251.62 | 10.31 | 268 | 138953 | 378412 | 63981099 |
Febrile neutropenia | 242.69 | 10.31 | 54 | 139167 | 187603 | 64171908 |
Product substitution issue | 239.40 | 10.31 | 241 | 138980 | 17620 | 64341891 |
Thrombocytopenia | 239.06 | 10.31 | 92 | 139129 | 223709 | 64135802 |
Temperature regulation disorder | 233.01 | 10.31 | 133 | 139088 | 4078 | 64355433 |
Agitation | 225.78 | 10.31 | 552 | 138669 | 87815 | 64271696 |
Poisoning | 224.08 | 10.31 | 256 | 138965 | 21623 | 64337888 |
Respiratory arrest | 223.05 | 10.31 | 406 | 138815 | 52579 | 64306932 |
Mydriasis | 196.82 | 10.31 | 202 | 139019 | 15110 | 64344401 |
Neutropenia | 194.78 | 10.31 | 140 | 139081 | 239484 | 64120027 |
Electrocardiogram QT prolonged | 193.15 | 10.31 | 487 | 138734 | 78961 | 64280550 |
Pyrexia | 188.37 | 10.31 | 600 | 138621 | 558044 | 63801467 |
Coeliac disease | 186.27 | 10.31 | 143 | 139078 | 7269 | 64352242 |
Tremor | 182.07 | 10.31 | 717 | 138504 | 147513 | 64211998 |
Food allergy | 164.23 | 10.31 | 136 | 139085 | 7715 | 64351796 |
Pancytopenia | 161.32 | 10.31 | 54 | 139167 | 143255 | 64216256 |
Asthma | 149.44 | 10.31 | 499 | 138722 | 94726 | 64264785 |
Drug withdrawal syndrome | 148.79 | 10.31 | 253 | 138968 | 31038 | 64328473 |
Sepsis | 148.39 | 10.31 | 167 | 139054 | 230174 | 64129337 |
General physical health deterioration | 143.18 | 10.31 | 138 | 139083 | 204287 | 64155224 |
Irritability | 141.42 | 10.31 | 271 | 138950 | 36475 | 64323036 |
Sinus tachycardia | 138.43 | 10.31 | 249 | 138972 | 31939 | 64327572 |
Exposure via ingestion | 135.22 | 10.31 | 100 | 139121 | 4802 | 64354709 |
Malignant neoplasm progression | 135.18 | 10.31 | 38 | 139183 | 112833 | 64246678 |
Postmortem blood drug level increased | 132.77 | 10.31 | 53 | 139168 | 708 | 64358803 |
Cardiac failure | 124.66 | 10.31 | 65 | 139156 | 132308 | 64227203 |
Myoclonus | 120.62 | 10.31 | 204 | 139017 | 24914 | 64334597 |
Renal impairment | 120.35 | 10.31 | 71 | 139150 | 134946 | 64224565 |
Platelet count decreased | 116.50 | 10.31 | 114 | 139107 | 167597 | 64191914 |
Hyperkalaemia | 115.74 | 10.31 | 37 | 139184 | 101092 | 64258419 |
Hyperhidrosis | 114.85 | 10.31 | 554 | 138667 | 124366 | 64235145 |
Immunodeficiency | 114.38 | 10.31 | 157 | 139064 | 15967 | 64343544 |
Dyspnoea | 112.41 | 10.31 | 1002 | 138219 | 717672 | 63641839 |
Insomnia | 109.63 | 10.31 | 767 | 138454 | 197069 | 64162442 |
Pneumonia | 108.57 | 10.31 | 735 | 138486 | 558841 | 63800670 |
Hyperreflexia | 106.11 | 10.31 | 102 | 139119 | 7046 | 64352465 |
Drug interaction | 105.54 | 10.31 | 1220 | 138001 | 360863 | 63998648 |
Sensitisation | 99.35 | 10.31 | 56 | 139165 | 1675 | 64357836 |
Headache | 98.26 | 10.31 | 1646 | 137575 | 527821 | 63831690 |
Bursitis | 97.27 | 10.31 | 170 | 139051 | 21315 | 64338196 |
Tardive dyskinesia | 96.70 | 10.31 | 109 | 139112 | 9069 | 64350442 |
Atrial fibrillation | 95.65 | 10.31 | 138 | 139083 | 170951 | 64188560 |
Polycystic ovaries | 95.54 | 10.31 | 59 | 139162 | 2096 | 64357415 |
Feeling abnormal | 93.73 | 10.31 | 550 | 138671 | 133052 | 64226459 |
Cardiogenic shock | 91.89 | 10.31 | 211 | 139010 | 32216 | 64327295 |
Disease progression | 90.88 | 10.31 | 103 | 139118 | 141577 | 64217934 |
Anger | 90.84 | 10.31 | 139 | 139082 | 15602 | 64343909 |
Septic shock | 90.40 | 10.31 | 58 | 139163 | 105379 | 64254132 |
Diarrhoea | 90.13 | 10.31 | 1063 | 138158 | 721641 | 63637870 |
Haemoglobin decreased | 85.76 | 10.31 | 183 | 139038 | 194880 | 64164631 |
Withdrawal syndrome | 85.20 | 10.31 | 169 | 139052 | 23323 | 64336188 |
Multiple organ dysfunction syndrome | 83.96 | 10.31 | 58 | 139163 | 101355 | 64258156 |
Pupil fixed | 82.63 | 10.31 | 63 | 139158 | 3169 | 64356342 |
Mental status changes | 81.69 | 10.31 | 304 | 138917 | 60858 | 64298653 |
Paranoia | 81.44 | 10.31 | 135 | 139086 | 16217 | 64343294 |
Memory impairment | 80.90 | 10.31 | 383 | 138838 | 85299 | 64274212 |
Migraine | 80.78 | 10.31 | 308 | 138913 | 62369 | 64297142 |
Ejection fraction | 80.36 | 10.31 | 44 | 139177 | 1242 | 64358269 |
Tachycardia | 78.22 | 10.31 | 572 | 138649 | 149007 | 64210504 |
Drug hypersensitivity | 76.81 | 10.31 | 818 | 138403 | 236997 | 64122514 |
Depression suicidal | 76.27 | 10.31 | 54 | 139167 | 2421 | 64357090 |
Tearfulness | 75.71 | 10.31 | 70 | 139151 | 4603 | 64354908 |
Psychiatric decompensation | 74.20 | 10.31 | 53 | 139168 | 2410 | 64357101 |
Renal failure | 72.95 | 10.31 | 179 | 139042 | 181509 | 64178002 |
Sympathomimetic effect | 72.74 | 10.31 | 19 | 139202 | 52 | 64359459 |
Mucosal inflammation | 71.41 | 10.31 | 23 | 139198 | 62561 | 64296950 |
Bone marrow failure | 70.17 | 10.31 | 10 | 139211 | 47942 | 64311569 |
Postictal state | 70.11 | 10.31 | 44 | 139177 | 1609 | 64357902 |
Loss of personal independence in daily activities | 69.95 | 10.31 | 326 | 138895 | 72128 | 64287383 |
Crying | 69.84 | 10.31 | 142 | 139079 | 19948 | 64339563 |
Panic attack | 69.19 | 10.31 | 145 | 139076 | 20808 | 64338703 |
Interstitial lung disease | 68.34 | 10.31 | 66 | 139155 | 97666 | 64261845 |
Pleural effusion | 67.88 | 10.31 | 105 | 139116 | 126454 | 64233057 |
Hepatic function abnormal | 67.66 | 10.31 | 27 | 139194 | 64286 | 64295225 |
Infusion related reaction | 67.63 | 10.31 | 160 | 139061 | 164307 | 64195204 |
Cholestasis | 66.50 | 10.31 | 9 | 139212 | 44863 | 64314648 |
Intentional product misuse | 65.95 | 10.31 | 320 | 138901 | 71975 | 64287536 |
Leukopenia | 65.57 | 10.31 | 73 | 139148 | 101169 | 64258342 |
Neutrophil count decreased | 65.44 | 10.31 | 43 | 139178 | 77153 | 64282358 |
White blood cell count decreased | 65.34 | 10.31 | 153 | 139068 | 157684 | 64201827 |
Hepatocellular injury | 64.88 | 10.31 | 10 | 139211 | 45225 | 64314286 |
Infarction | 63.54 | 10.31 | 59 | 139162 | 3901 | 64355610 |
Gastrointestinal haemorrhage | 63.40 | 10.31 | 118 | 139103 | 132194 | 64227317 |
Pulseless electrical activity | 63.21 | 10.31 | 105 | 139116 | 12634 | 64346877 |
Peripheral swelling | 63.20 | 10.31 | 235 | 138986 | 208918 | 64150593 |
Emotional distress | 62.97 | 10.31 | 196 | 139025 | 35842 | 64323669 |
Hallucination | 62.72 | 10.31 | 317 | 138904 | 72471 | 64287040 |
Distributive shock | 62.67 | 10.31 | 43 | 139178 | 1832 | 64357679 |
Swelling | 62.63 | 10.31 | 160 | 139061 | 160058 | 64199453 |
Areflexia | 62.44 | 10.31 | 65 | 139156 | 4942 | 64354569 |
Lupus-like syndrome | 61.45 | 10.31 | 85 | 139136 | 8706 | 64350805 |
Cytomegalovirus infection | 61.43 | 10.31 | 5 | 139216 | 37194 | 64322317 |
Helicobacter infection | 61.08 | 10.31 | 6 | 139215 | 38356 | 64321155 |
Lower respiratory tract infection | 60.42 | 10.31 | 69 | 139152 | 94545 | 64264966 |
Clonus | 58.77 | 10.31 | 69 | 139152 | 5998 | 64353513 |
Hypokalaemia | 58.15 | 10.31 | 109 | 139112 | 121794 | 64237717 |
Hypoglycaemia | 58.01 | 10.31 | 65 | 139156 | 89827 | 64269684 |
Psychotic disorder | 57.61 | 10.31 | 185 | 139036 | 34393 | 64325118 |
Bronchial neoplasm | 57.55 | 10.31 | 25 | 139196 | 418 | 64359093 |
Disturbance in attention | 57.23 | 10.31 | 207 | 139014 | 40867 | 64318644 |
Hyponatraemia | 56.55 | 10.31 | 150 | 139071 | 148189 | 64211322 |
Sleep apnoea syndrome | 55.63 | 10.31 | 166 | 139055 | 29666 | 64329845 |
Melaena | 55.48 | 10.31 | 23 | 139198 | 53525 | 64305986 |
Psoriasis | 55.40 | 10.31 | 303 | 138918 | 71400 | 64288111 |
Lung disorder | 55.38 | 10.31 | 31 | 139190 | 60669 | 64298842 |
Product quality issue | 53.86 | 10.31 | 164 | 139057 | 29635 | 64329876 |
Duodenal ulcer perforation | 53.62 | 10.31 | 6 | 139215 | 34619 | 64324892 |
Joint dislocation | 53.57 | 10.31 | 92 | 139129 | 11373 | 64348138 |
Brain injury | 53.33 | 10.31 | 85 | 139136 | 9880 | 64349631 |
Rubber sensitivity | 52.87 | 10.31 | 34 | 139187 | 1298 | 64358213 |
Arthropathy | 52.71 | 10.31 | 114 | 139107 | 120853 | 64238658 |
Cerebral venous thrombosis | 52.55 | 10.31 | 43 | 139178 | 2398 | 64357113 |
International normalised ratio increased | 52.46 | 10.31 | 56 | 139165 | 79111 | 64280400 |
Cholecystitis chronic | 52.17 | 10.31 | 81 | 139140 | 9206 | 64350305 |
Ascites | 51.92 | 10.31 | 35 | 139186 | 61966 | 64297545 |
Depressive symptom | 51.87 | 10.31 | 56 | 139165 | 4440 | 64355071 |
Nasal turbinate hypertrophy | 51.31 | 10.31 | 25 | 139196 | 550 | 64358961 |
Cerebral haemorrhage | 51.25 | 10.31 | 23 | 139198 | 51067 | 64308444 |
Multiple sclerosis relapse | 51.24 | 10.31 | 200 | 139021 | 40935 | 64318576 |
Unresponsive to stimuli | 51.05 | 10.31 | 230 | 138991 | 50163 | 64309348 |
Foot deformity | 50.80 | 10.31 | 111 | 139110 | 16393 | 64343118 |
Treatment failure | 50.15 | 10.31 | 111 | 139110 | 116705 | 64242806 |
Jaundice | 50.00 | 10.31 | 21 | 139200 | 48491 | 64311020 |
Persistent genital arousal disorder | 49.58 | 10.31 | 19 | 139202 | 226 | 64359285 |
Neuropathy peripheral | 49.37 | 10.31 | 113 | 139108 | 117412 | 64242099 |
Mental disorder | 49.17 | 10.31 | 147 | 139074 | 26298 | 64333213 |
Liver disorder | 49.02 | 10.31 | 27 | 139194 | 53324 | 64306187 |
Sexual dysfunction | 48.92 | 10.31 | 65 | 139156 | 6406 | 64353105 |
Joint swelling | 48.87 | 10.31 | 269 | 138952 | 215113 | 64144398 |
Therapeutic response unexpected | 48.58 | 10.31 | 111 | 139110 | 16890 | 64342621 |
Weight increased | 48.49 | 10.31 | 687 | 138534 | 212661 | 64146850 |
Gamma-glutamyltransferase increased | 48.41 | 10.31 | 22 | 139199 | 48488 | 64311023 |
Blood creatinine increased | 48.27 | 10.31 | 142 | 139079 | 135640 | 64223871 |
Akathisia | 48.15 | 10.31 | 88 | 139133 | 11422 | 64348089 |
Hostility | 47.77 | 10.31 | 39 | 139182 | 2168 | 64357343 |
Pneumocystis jirovecii pneumonia | 47.69 | 10.31 | 3 | 139218 | 27631 | 64331880 |
Product residue present | 47.62 | 10.31 | 46 | 139175 | 3196 | 64356315 |
Hepatic failure | 46.75 | 10.31 | 31 | 139190 | 55363 | 64304148 |
Brugada syndrome | 46.49 | 10.31 | 29 | 139192 | 1049 | 64358462 |
Depressed mood | 45.99 | 10.31 | 193 | 139028 | 40819 | 64318692 |
Off label use | 45.88 | 10.31 | 1029 | 138192 | 631777 | 63727734 |
Nicotine dependence | 45.82 | 10.31 | 26 | 139195 | 788 | 64358723 |
Epistaxis | 45.70 | 10.31 | 89 | 139132 | 98042 | 64261469 |
Libido decreased | 45.67 | 10.31 | 54 | 139167 | 4730 | 64354781 |
Blister | 45.52 | 10.31 | 65 | 139156 | 80902 | 64278609 |
Toxic epidermal necrolysis | 45.44 | 10.31 | 12 | 139209 | 37154 | 64322357 |
Mania | 45.07 | 10.31 | 105 | 139116 | 16181 | 64343330 |
Product odour abnormal | 44.70 | 10.31 | 29 | 139192 | 1124 | 64358387 |
Stomatitis | 43.95 | 10.31 | 108 | 139113 | 109497 | 64250014 |
Libido increased | 43.81 | 10.31 | 34 | 139187 | 1756 | 64357755 |
Respiratory failure | 43.68 | 10.31 | 189 | 139032 | 160994 | 64198517 |
Endometrial ablation | 43.52 | 10.31 | 25 | 139196 | 776 | 64358735 |
Autonomic nervous system imbalance | 43.40 | 10.31 | 49 | 139172 | 4083 | 64355428 |
Drug reaction with eosinophilia and systemic symptoms | 42.28 | 10.31 | 33 | 139188 | 54184 | 64305327 |
Multiple sclerosis | 41.77 | 10.31 | 112 | 139109 | 18829 | 64340682 |
Muscle twitching | 41.56 | 10.31 | 112 | 139109 | 18886 | 64340625 |
Incorrect route of product administration | 40.96 | 10.31 | 127 | 139094 | 23171 | 64336340 |
Major depression | 40.91 | 10.31 | 66 | 139155 | 7750 | 64351761 |
Carpal tunnel syndrome | 40.51 | 10.31 | 99 | 139122 | 15729 | 64343782 |
Decreased appetite | 39.55 | 10.31 | 402 | 138819 | 280887 | 64078624 |
Intentional self-injury | 39.30 | 10.31 | 145 | 139076 | 28899 | 64330612 |
Rhinitis allergic | 39.30 | 10.31 | 66 | 139155 | 8012 | 64351499 |
Affective disorder | 39.23 | 10.31 | 59 | 139162 | 6521 | 64352990 |
Fibromyalgia | 39.17 | 10.31 | 167 | 139054 | 35564 | 64323947 |
Pemphigus | 39.04 | 10.31 | 44 | 139177 | 60657 | 64298854 |
Sleep-related eating disorder | 38.97 | 10.31 | 22 | 139199 | 660 | 64358851 |
Pneumonitis | 38.84 | 10.31 | 31 | 139190 | 50334 | 64309177 |
Haematuria | 38.71 | 10.31 | 44 | 139177 | 60427 | 64299084 |
Therapeutic product effect incomplete | 38.67 | 10.31 | 367 | 138854 | 103115 | 64256396 |
Product complaint | 38.63 | 10.31 | 82 | 139139 | 11872 | 64347639 |
Systemic lupus erythematosus | 38.25 | 10.31 | 68 | 139153 | 77544 | 64281967 |
Rash | 38.09 | 10.31 | 729 | 138492 | 457820 | 63901691 |
Hand deformity | 37.71 | 10.31 | 48 | 139173 | 62723 | 64296788 |
Vision blurred | 37.66 | 10.31 | 328 | 138893 | 89988 | 64269523 |
Exostosis | 37.58 | 10.31 | 79 | 139142 | 11359 | 64348152 |
Muscle injury | 37.56 | 10.31 | 6 | 139215 | 26431 | 64333080 |
Rash maculo-papular | 37.46 | 10.31 | 28 | 139193 | 46998 | 64312513 |
Agranulocytosis | 37.13 | 10.31 | 18 | 139203 | 38211 | 64321300 |
Thinking abnormal | 37.03 | 10.31 | 79 | 139142 | 11477 | 64348034 |
Mood altered | 36.78 | 10.31 | 96 | 139125 | 15883 | 64343628 |
Disseminated intravascular coagulation | 36.70 | 10.31 | 12 | 139209 | 32336 | 64327175 |
Upper gastrointestinal haemorrhage | 36.69 | 10.31 | 15 | 139206 | 35205 | 64324306 |
Drug eruption | 36.67 | 10.31 | 16 | 139205 | 36120 | 64323391 |
Euphoric mood | 36.35 | 10.31 | 57 | 139164 | 6534 | 64352977 |
Folliculitis | 36.23 | 10.31 | 10 | 139211 | 30067 | 64329444 |
Lactic acidosis | 35.82 | 10.31 | 48 | 139173 | 61362 | 64298149 |
Infection | 35.61 | 10.31 | 243 | 138978 | 184637 | 64174874 |
Nightmare | 35.59 | 10.31 | 113 | 139108 | 20880 | 64338631 |
Osteonecrosis of jaw | 35.38 | 10.31 | 21 | 139200 | 39804 | 64319707 |
Syncope | 35.13 | 10.31 | 198 | 139023 | 157437 | 64202074 |
Gastrooesophageal reflux disease | 34.69 | 10.31 | 302 | 138919 | 82841 | 64276670 |
C-reactive protein increased | 34.64 | 10.31 | 98 | 139123 | 94811 | 64264700 |
Vertigo | 34.52 | 10.31 | 232 | 138989 | 58779 | 64300732 |
Maternal exposure during pregnancy | 34.27 | 10.31 | 100 | 139121 | 95784 | 64263727 |
Hyponatraemic coma | 34.10 | 10.31 | 9 | 139212 | 26 | 64359485 |
Tinnitus | 33.98 | 10.31 | 155 | 139066 | 33978 | 64325533 |
Gastrointestinal disorder | 33.96 | 10.31 | 91 | 139130 | 89618 | 64269893 |
Bronchial haemorrhage | 33.86 | 10.31 | 25 | 139196 | 1197 | 64358314 |
Hallucination, visual | 33.59 | 10.31 | 134 | 139087 | 27700 | 64331811 |
Myelodysplastic syndrome | 33.54 | 10.31 | 9 | 139212 | 27570 | 64331941 |
Pericarditis | 33.38 | 10.31 | 52 | 139169 | 62464 | 64297047 |
Retinitis | 33.33 | 10.31 | 31 | 139190 | 2054 | 64357457 |
Rhinitis perennial | 33.07 | 10.31 | 14 | 139207 | 219 | 64359292 |
Blood lactate dehydrogenase increased | 33.01 | 10.31 | 15 | 139206 | 33063 | 64326448 |
Sedation | 32.55 | 10.31 | 176 | 139045 | 41286 | 64318225 |
Cough | 32.44 | 10.31 | 458 | 138763 | 301690 | 64057821 |
Impaired work ability | 31.57 | 10.31 | 88 | 139133 | 15131 | 64344380 |
Device expulsion | 31.57 | 10.31 | 109 | 139112 | 21027 | 64338484 |
Haematemesis | 31.40 | 10.31 | 33 | 139188 | 46966 | 64312545 |
Complication of device insertion | 31.40 | 10.31 | 46 | 139175 | 4966 | 64354545 |
Bipolar disorder | 31.25 | 10.31 | 54 | 139167 | 6707 | 64352804 |
Upper respiratory tract infection | 31.22 | 10.31 | 266 | 138955 | 72519 | 64286992 |
Dysphemia | 31.09 | 10.31 | 36 | 139185 | 3083 | 64356428 |
Posterior reversible encephalopathy syndrome | 30.87 | 10.31 | 6 | 139215 | 22940 | 64336571 |
Endometriosis | 30.86 | 10.31 | 34 | 139187 | 2758 | 64356753 |
Rash erythematous | 30.76 | 10.31 | 195 | 139026 | 48438 | 64311073 |
Fluid retention | 30.58 | 10.31 | 227 | 138994 | 59379 | 64300132 |
Decreased interest | 30.55 | 10.31 | 37 | 139184 | 3323 | 64356188 |
Urine amphetamine positive | 30.52 | 10.31 | 10 | 139211 | 72 | 64359439 |
Nephrectomy | 30.51 | 10.31 | 25 | 139196 | 1397 | 64358114 |
Bronchopulmonary aspergillosis | 30.34 | 10.31 | 3 | 139218 | 19082 | 64340429 |
Amnesia | 30.20 | 10.31 | 193 | 139028 | 48076 | 64311435 |
Asthenia | 30.10 | 10.31 | 699 | 138522 | 427345 | 63932166 |
Hypomagnesaemia | 30.10 | 10.31 | 22 | 139199 | 37354 | 64322157 |
Alcoholism | 30.05 | 10.31 | 37 | 139184 | 3380 | 64356131 |
Anaphylactic shock | 29.88 | 10.31 | 14 | 139207 | 30314 | 64329197 |
Obsessive-compulsive disorder | 29.87 | 10.31 | 44 | 139177 | 4774 | 64354737 |
Obesity | 29.81 | 10.31 | 105 | 139116 | 20457 | 64339054 |
Psychomotor skills impaired | 29.65 | 10.31 | 39 | 139182 | 3806 | 64355705 |
Sleep disorder due to a general medical condition | 29.57 | 10.31 | 59 | 139162 | 8175 | 64351336 |
Polyneuropathy | 29.45 | 10.31 | 4 | 139217 | 19890 | 64339621 |
Oedema peripheral | 29.37 | 10.31 | 301 | 138920 | 210016 | 64149495 |
Abnormal behaviour | 29.35 | 10.31 | 147 | 139074 | 33475 | 64326036 |
Hypothyroidism | 29.27 | 10.31 | 168 | 139053 | 40289 | 64319222 |
Sleep paralysis | 29.21 | 10.31 | 17 | 139204 | 541 | 64358970 |
Hepatotoxicity | 29.09 | 10.31 | 26 | 139195 | 39936 | 64319575 |
Vomiting | 28.94 | 10.31 | 938 | 138283 | 550179 | 63809332 |
Bradyphrenia | 28.65 | 10.31 | 63 | 139158 | 9343 | 64350168 |
Apathy | 28.47 | 10.31 | 70 | 139151 | 11162 | 64348349 |
Acute myeloid leukaemia | 28.12 | 10.31 | 12 | 139209 | 27451 | 64332060 |
Haemoptysis | 27.94 | 10.31 | 39 | 139182 | 49009 | 64310502 |
Malaise | 27.88 | 10.31 | 647 | 138574 | 395600 | 63963911 |
Drug resistance | 27.83 | 10.31 | 21 | 139200 | 35081 | 64324430 |
Disorientation | 27.73 | 10.31 | 211 | 139010 | 55617 | 64303894 |
C-reactive protein abnormal | 27.72 | 10.31 | 14 | 139207 | 29033 | 64330478 |
Corneal reflex decreased | 27.67 | 10.31 | 14 | 139207 | 335 | 64359176 |
Colitis | 27.50 | 10.31 | 53 | 139168 | 58621 | 64300890 |
Haemorrhage | 27.46 | 10.31 | 84 | 139137 | 79267 | 64280244 |
Eosinophilia | 27.45 | 10.31 | 25 | 139196 | 38051 | 64321460 |
Haemophagocytic lymphohistiocytosis | 27.40 | 10.31 | 3 | 139218 | 17606 | 64341905 |
Hypercalcaemia | 27.30 | 10.31 | 17 | 139204 | 31399 | 64328112 |
Hepatitis | 27.23 | 10.31 | 35 | 139186 | 45547 | 64313964 |
Feeling jittery | 26.66 | 10.31 | 66 | 139155 | 10569 | 64348942 |
Oesophageal spasm | 26.62 | 10.31 | 30 | 139191 | 2495 | 64357016 |
Tubulointerstitial nephritis | 26.48 | 10.31 | 17 | 139204 | 30892 | 64328619 |
Pruritus | 26.41 | 10.31 | 495 | 138726 | 311905 | 64047606 |
Impaired healing | 26.32 | 10.31 | 57 | 139164 | 60416 | 64299095 |
Electroencephalogram abnormal | 25.96 | 10.31 | 43 | 139178 | 5160 | 64354351 |
Tongue biting | 25.90 | 10.31 | 25 | 139196 | 1735 | 64357776 |
Injection site mass | 25.74 | 10.31 | 89 | 139132 | 17181 | 64342330 |
Mucosal dryness | 25.60 | 10.31 | 32 | 139189 | 2969 | 64356542 |
Dissociation | 25.51 | 10.31 | 32 | 139189 | 2979 | 64356532 |
Thrombotic microangiopathy | 25.50 | 10.31 | 3 | 139218 | 16652 | 64342859 |
Cardiac failure congestive | 25.45 | 10.31 | 171 | 139050 | 130409 | 64229102 |
Anuria | 25.43 | 10.31 | 5 | 139216 | 18959 | 64340552 |
Metastases to liver | 25.26 | 10.31 | 10 | 139211 | 23931 | 64335580 |
Basilar artery occlusion | 25.00 | 10.31 | 11 | 139210 | 190 | 64359321 |
Uterine perforation | 24.98 | 10.31 | 45 | 139176 | 5775 | 64353736 |
Hallucinations, mixed | 24.97 | 10.31 | 46 | 139175 | 6006 | 64353505 |
Nervousness | 24.94 | 10.31 | 128 | 139093 | 29428 | 64330083 |
Nephropathy toxic | 24.82 | 10.31 | 4 | 139217 | 17510 | 64342001 |
Pericardial effusion | 24.65 | 10.31 | 29 | 139192 | 39225 | 64320286 |
Anti-neutrophil cytoplasmic antibody positive vasculitis | 24.55 | 10.31 | 31 | 139190 | 2905 | 64356606 |
Drug dependence | 24.54 | 10.31 | 139 | 139082 | 33173 | 64326338 |
Dehydration | 24.53 | 10.31 | 325 | 138896 | 216438 | 64143073 |
Restless legs syndrome | 24.47 | 10.31 | 87 | 139134 | 17029 | 64342482 |
Pneumothorax | 24.27 | 10.31 | 11 | 139210 | 24287 | 64335224 |
Burning sensation | 24.27 | 10.31 | 187 | 139034 | 49477 | 64310034 |
Impulse-control disorder | 24.21 | 10.31 | 23 | 139198 | 1565 | 64357946 |
Haematoma | 24.19 | 10.31 | 39 | 139182 | 46211 | 64313300 |
Dyspnoea exertional | 24.15 | 10.31 | 80 | 139141 | 73650 | 64285861 |
Brain death | 24.02 | 10.31 | 40 | 139181 | 4821 | 64354690 |
Erythema dyschromicum perstans | 24.02 | 10.31 | 8 | 139213 | 61 | 64359450 |
Cerebral infarction | 24.02 | 10.31 | 32 | 139189 | 41012 | 64318499 |
Peritonitis | 23.97 | 10.31 | 12 | 139209 | 25011 | 64334500 |
Abnormal dreams | 23.61 | 10.31 | 62 | 139159 | 10294 | 64349217 |
Oedema | 23.57 | 10.31 | 110 | 139111 | 91825 | 64267686 |
Shock haemorrhagic | 23.43 | 10.31 | 4 | 139217 | 16787 | 64342724 |
Solar urticaria | 23.26 | 10.31 | 8 | 139213 | 68 | 64359443 |
Device dislocation | 23.22 | 10.31 | 99 | 139122 | 21079 | 64338432 |
Anorgasmia | 23.17 | 10.31 | 18 | 139203 | 931 | 64358580 |
Sputum purulent | 23.10 | 10.31 | 20 | 139201 | 1206 | 64358305 |
Economic problem | 23.08 | 10.31 | 26 | 139195 | 2161 | 64357350 |
Skin ulcer | 23.07 | 10.31 | 37 | 139184 | 43937 | 64315574 |
Heart rate decreased | 23.07 | 10.31 | 53 | 139168 | 55014 | 64304497 |
Anti-cyclic citrullinated peptide antibody positive | 23.03 | 10.31 | 45 | 139176 | 49517 | 64309994 |
Wound | 23.02 | 10.31 | 86 | 139135 | 76391 | 64283120 |
Orgasm abnormal | 22.98 | 10.31 | 10 | 139211 | 168 | 64359343 |
Drug screen positive | 22.96 | 10.31 | 43 | 139178 | 5686 | 64353825 |
Neoplasm progression | 22.91 | 10.31 | 33 | 139188 | 40931 | 64318580 |
Blood bilirubin increased | 22.84 | 10.31 | 57 | 139164 | 57496 | 64302015 |
Substance abuse | 22.60 | 10.31 | 57 | 139164 | 9235 | 64350276 |
Gambling disorder | 22.57 | 10.31 | 24 | 139197 | 1870 | 64357641 |
Dyskinesia | 22.52 | 10.31 | 154 | 139067 | 39234 | 64320277 |
Transplant rejection | 22.48 | 10.31 | 5 | 139216 | 17396 | 64342115 |
Soft tissue injury | 22.44 | 10.31 | 22 | 139199 | 1557 | 64357954 |
Balance disorder | 22.25 | 10.31 | 278 | 138943 | 83648 | 64275863 |
Device related infection | 22.20 | 10.31 | 20 | 139201 | 30606 | 64328905 |
Infusion site scar | 22.09 | 10.31 | 11 | 139210 | 254 | 64359257 |
Bronchial disorder | 22.08 | 10.31 | 25 | 139196 | 2090 | 64357421 |
Accidental poisoning | 22.07 | 10.31 | 21 | 139200 | 1432 | 64358079 |
Accidental exposure to product by child | 22.00 | 10.31 | 27 | 139194 | 2458 | 64357053 |
Oesophageal pain | 21.99 | 10.31 | 31 | 139190 | 3232 | 64356279 |
Muscle rigidity | 21.79 | 10.31 | 85 | 139136 | 17388 | 64342123 |
Rectal haemorrhage | 21.70 | 10.31 | 65 | 139156 | 61752 | 64297759 |
Anhedonia | 21.63 | 10.31 | 72 | 139149 | 13634 | 64345877 |
Pancreatitis acute | 21.61 | 10.31 | 37 | 139184 | 42818 | 64316693 |
Blood pressure decreased | 21.59 | 10.31 | 104 | 139117 | 86095 | 64273416 |
Dysphoria | 21.54 | 10.31 | 36 | 139185 | 4352 | 64355159 |
Self esteem decreased | 21.54 | 10.31 | 17 | 139204 | 900 | 64358611 |
Arthralgia | 21.48 | 10.31 | 760 | 138461 | 441500 | 63918011 |
Central nervous system necrosis | 21.37 | 10.31 | 11 | 139210 | 273 | 64359238 |
Dystonia | 21.32 | 10.31 | 89 | 139132 | 18776 | 64340735 |
Feeling of despair | 21.29 | 10.31 | 27 | 139194 | 2541 | 64356970 |
Attention deficit hyperactivity disorder | 21.21 | 10.31 | 28 | 139193 | 2742 | 64356769 |
Injury | 21.12 | 10.31 | 199 | 139022 | 55793 | 64303718 |
Psychomotor retardation | 21.11 | 10.31 | 39 | 139182 | 5104 | 64354407 |
Pallor | 20.95 | 10.31 | 32 | 139189 | 38749 | 64320762 |
Hypomania | 20.89 | 10.31 | 41 | 139180 | 5613 | 64353898 |
Angina pectoris | 20.88 | 10.31 | 41 | 139180 | 45040 | 64314471 |
Hallucination, auditory | 20.80 | 10.31 | 82 | 139139 | 16857 | 64342654 |
Feelings of worthlessness | 20.77 | 10.31 | 13 | 139208 | 473 | 64359038 |
Nasopharyngitis | 20.74 | 10.31 | 298 | 138923 | 195775 | 64163736 |
Clostridium difficile colitis | 20.68 | 10.31 | 17 | 139204 | 27206 | 64332305 |
Aspergillus infection | 20.58 | 10.31 | 5 | 139216 | 16374 | 64343137 |
Metastases to lung | 20.52 | 10.31 | 4 | 139217 | 15260 | 64344251 |
Sleep disorder due to general medical condition, insomnia type | 20.47 | 10.31 | 16 | 139205 | 26254 | 64333257 |
Hepatic encephalopathy | 20.33 | 10.31 | 10 | 139211 | 21056 | 64338455 |
Psychomotor hyperactivity | 20.27 | 10.31 | 73 | 139148 | 14378 | 64345133 |
Pulmonary oedema | 20.24 | 10.31 | 94 | 139127 | 78580 | 64280931 |
Cardiomyopathy acute | 20.04 | 10.31 | 10 | 139211 | 232 | 64359279 |
Drug tolerance | 19.96 | 10.31 | 42 | 139179 | 6043 | 64353468 |
Somnolence | 19.88 | 10.31 | 578 | 138643 | 203067 | 64156444 |
Stress | 19.86 | 10.31 | 209 | 139012 | 60325 | 64299186 |
Urine sodium increased | 19.77 | 10.31 | 9 | 139212 | 169 | 64359342 |
Gallbladder disorder | 19.76 | 10.31 | 81 | 139140 | 16949 | 64342562 |
Erectile dysfunction | 19.63 | 10.31 | 66 | 139155 | 12561 | 64346950 |
Blood pressure systolic increased | 19.60 | 10.31 | 49 | 139172 | 49404 | 64310107 |
Compulsive shopping | 19.54 | 10.31 | 15 | 139206 | 762 | 64358749 |
Palmar-plantar erythrodysaesthesia syndrome | 19.52 | 10.31 | 20 | 139201 | 28799 | 64330712 |
Adrenergic syndrome | 19.51 | 10.31 | 8 | 139213 | 115 | 64359396 |
Hypocalcaemia | 19.32 | 10.31 | 38 | 139183 | 41715 | 64317796 |
Glossodynia | 19.31 | 10.31 | 73 | 139148 | 64623 | 64294888 |
Serum sickness-like reaction | 19.30 | 10.31 | 13 | 139208 | 537 | 64358974 |
Bone erosion | 19.28 | 10.31 | 62 | 139159 | 11533 | 64347978 |
Oliguria | 19.22 | 10.31 | 4 | 139217 | 14572 | 64344939 |
Extra dose administered | 19.20 | 10.31 | 44 | 139177 | 6706 | 64352805 |
Synovitis | 19.18 | 10.31 | 130 | 139091 | 98960 | 64260551 |
Binge eating | 19.14 | 10.31 | 12 | 139209 | 438 | 64359073 |
Electrocardiogram PR prolongation | 19.10 | 10.31 | 19 | 139202 | 1368 | 64358143 |
Dry mouth | 19.07 | 10.31 | 207 | 139014 | 60211 | 64299300 |
Post-traumatic neck syndrome | 19.04 | 10.31 | 22 | 139199 | 1880 | 64357631 |
Bacteraemia | 19.01 | 10.31 | 18 | 139203 | 26893 | 64332618 |
Blood pressure fluctuation | 18.60 | 10.31 | 54 | 139167 | 51817 | 64307694 |
Cytokine release syndrome | 18.48 | 10.31 | 11 | 139210 | 20818 | 64338693 |
Dependence | 18.41 | 10.31 | 23 | 139198 | 2132 | 64357379 |
Liver function test abnormal | 18.40 | 10.31 | 66 | 139155 | 59335 | 64300176 |
Treatment noncompliance | 18.16 | 10.31 | 158 | 139063 | 43324 | 64316187 |
Acute myocardial infarction | 18.12 | 10.31 | 83 | 139138 | 69635 | 64289876 |
Cardiotoxicity | 18.05 | 10.31 | 56 | 139165 | 10218 | 64349293 |
Urinary tract infection | 18.03 | 10.31 | 372 | 138849 | 231224 | 64128287 |
Left ventricular dysfunction | 18.02 | 10.31 | 7 | 139214 | 16947 | 64342564 |
Plasma cell myeloma | 18.00 | 10.31 | 46 | 139175 | 46029 | 64313482 |
Emotional disorder | 17.95 | 10.31 | 64 | 139157 | 12543 | 64346968 |
Loss of libido | 17.95 | 10.31 | 24 | 139197 | 2380 | 64357131 |
Marital problem | 17.91 | 10.31 | 9 | 139212 | 212 | 64359299 |
Device placement issue | 17.89 | 10.31 | 14 | 139207 | 732 | 64358779 |
Enterococcal infection | 17.88 | 10.31 | 4 | 139217 | 13862 | 64345649 |
Herpes zoster | 17.88 | 10.31 | 99 | 139122 | 79088 | 64280423 |
Liver injury | 17.86 | 10.31 | 23 | 139198 | 29909 | 64329602 |
Subacute cutaneous lupus erythematosus | 17.86 | 10.31 | 27 | 139194 | 2998 | 64356513 |
Partner stress | 17.83 | 10.31 | 10 | 139211 | 296 | 64359215 |
Blood test abnormal | 17.83 | 10.31 | 65 | 139156 | 12878 | 64346633 |
Graft versus host disease | 17.78 | 10.31 | 4 | 139217 | 13809 | 64345702 |
Product dose omission issue | 17.73 | 10.31 | 548 | 138673 | 194199 | 64165312 |
Homicidal ideation | 17.73 | 10.31 | 28 | 139193 | 3229 | 64356282 |
Hyperbilirubinaemia | 17.71 | 10.31 | 12 | 139209 | 21193 | 64338318 |
Sternal fracture | 17.65 | 10.31 | 23 | 139198 | 2224 | 64357287 |
Chronic fatigue syndrome | 17.64 | 10.31 | 17 | 139204 | 1178 | 64358333 |
Oculocephalogyric reflex absent | 17.51 | 10.31 | 5 | 139216 | 21 | 64359490 |
Poor personal hygiene | 17.45 | 10.31 | 12 | 139209 | 513 | 64358998 |
Brain stem syndrome | 17.34 | 10.31 | 14 | 139207 | 766 | 64358745 |
Delusion | 17.33 | 10.31 | 81 | 139140 | 17933 | 64341578 |
Drug specific antibody | 17.33 | 10.31 | 22 | 139199 | 2073 | 64357438 |
Large intestine anastomosis | 17.30 | 10.31 | 7 | 139214 | 97 | 64359414 |
Automatism | 17.30 | 10.31 | 8 | 139213 | 156 | 64359355 |
Sudden death | 17.29 | 10.31 | 11 | 139210 | 20085 | 64339426 |
Generalised anxiety disorder | 17.27 | 10.31 | 21 | 139200 | 1894 | 64357617 |
Compartment syndrome | 17.25 | 10.31 | 32 | 139189 | 4200 | 64355311 |
Mood swings | 17.14 | 10.31 | 79 | 139142 | 17389 | 64342122 |
Prescribed overdose | 17.12 | 10.31 | 88 | 139133 | 20243 | 64339268 |
Basal cell carcinoma | 17.09 | 10.31 | 25 | 139196 | 30813 | 64328698 |
Respiratory distress | 16.98 | 10.31 | 57 | 139164 | 52274 | 64307237 |
Atrioventricular block complete | 16.98 | 10.31 | 5 | 139216 | 14413 | 64345098 |
Dyspareunia | 16.86 | 10.31 | 20 | 139201 | 1757 | 64357754 |
Thalamic infarction | 16.75 | 10.31 | 16 | 139205 | 1096 | 64358415 |
Supraventricular tachycardia | 16.74 | 10.31 | 83 | 139138 | 18824 | 64340687 |
Biliary dyskinesia | 16.68 | 10.31 | 23 | 139198 | 2349 | 64357162 |
Choreoathetosis | 16.65 | 10.31 | 18 | 139203 | 1429 | 64358082 |
Dermatitis bullous | 16.54 | 10.31 | 3 | 139218 | 12051 | 64347460 |
Metastases to bone | 16.49 | 10.31 | 12 | 139209 | 20423 | 64339088 |
Haemolytic anaemia | 16.46 | 10.31 | 7 | 139214 | 16046 | 64343465 |
Rhonchi | 16.46 | 10.31 | 28 | 139193 | 3435 | 64356076 |
Oscillopsia | 16.42 | 10.31 | 8 | 139213 | 176 | 64359335 |
Liver function test increased | 16.30 | 10.31 | 26 | 139195 | 30944 | 64328567 |
Abdominal pain | 16.27 | 10.31 | 532 | 138689 | 311843 | 64047668 |
Injection site reaction | 16.20 | 10.31 | 163 | 139058 | 46501 | 64313010 |
Hyperglycaemia | 16.19 | 10.31 | 72 | 139149 | 60896 | 64298615 |
Substance use disorder | 16.15 | 10.31 | 10 | 139211 | 357 | 64359154 |
Tenosynovitis | 16.12 | 10.31 | 3 | 139218 | 11830 | 64347681 |
Inadequate analgesia | 16.12 | 10.31 | 30 | 139191 | 3948 | 64355563 |
Haematochezia | 16.09 | 10.31 | 81 | 139140 | 66292 | 64293219 |
Staphylococcal sepsis | 16.08 | 10.31 | 4 | 139217 | 12895 | 64346616 |
Lymphopenia | 16.06 | 10.31 | 19 | 139202 | 25638 | 64333873 |
Impulsive behaviour | 16.05 | 10.31 | 24 | 139197 | 2639 | 64356872 |
Anticholinergic syndrome | 16.01 | 10.31 | 24 | 139197 | 2645 | 64356866 |
Urine osmolarity increased | 16.00 | 10.31 | 9 | 139212 | 268 | 64359243 |
Suicidal behaviour | 15.96 | 10.31 | 25 | 139196 | 2862 | 64356649 |
Poor quality sleep | 15.94 | 10.31 | 82 | 139139 | 18869 | 64340642 |
Wound infection fungal | 15.86 | 10.31 | 8 | 139213 | 190 | 64359321 |
Vaginal haemorrhage | 15.79 | 10.31 | 83 | 139138 | 19261 | 64340250 |
Hypertensive crisis | 15.68 | 10.31 | 10 | 139211 | 18238 | 64341273 |
Haemoglobin urine | 15.65 | 10.31 | 7 | 139214 | 126 | 64359385 |
Bruxism | 15.53 | 10.31 | 28 | 139193 | 3596 | 64355915 |
Prostate cancer | 15.49 | 10.31 | 12 | 139209 | 19783 | 64339728 |
Gun shot wound | 15.45 | 10.31 | 15 | 139206 | 1049 | 64358462 |
Corneal light reflex test abnormal | 15.42 | 10.31 | 3 | 139218 | 0 | 64359511 |
Cardiac failure acute | 15.41 | 10.31 | 8 | 139213 | 16336 | 64343175 |
Gastric ulcer | 15.34 | 10.31 | 26 | 139195 | 30208 | 64329303 |
Bipolar I disorder | 15.29 | 10.31 | 19 | 139202 | 1752 | 64357759 |
Duodenal ulcer | 15.28 | 10.31 | 6 | 139215 | 14429 | 64345082 |
Postmortem blood drug level abnormal | 15.21 | 10.31 | 12 | 139209 | 635 | 64358876 |
Road traffic accident | 15.15 | 10.31 | 116 | 139105 | 30629 | 64328882 |
Orthostatic hypotension | 15.10 | 10.31 | 51 | 139170 | 46687 | 64312824 |
Oxygen saturation decreased | 15.10 | 10.31 | 153 | 139068 | 107023 | 64252488 |
Injection site induration | 15.07 | 10.31 | 48 | 139173 | 8884 | 64350627 |
Body height decreased | 15.01 | 10.31 | 43 | 139178 | 7511 | 64352000 |
Post-traumatic stress disorder | 14.94 | 10.31 | 30 | 139191 | 4175 | 64355336 |
Priapism | 14.93 | 10.31 | 29 | 139192 | 3941 | 64355570 |
Premature delivery | 14.89 | 10.31 | 11 | 139210 | 18578 | 64340933 |
Decorticate posture | 14.87 | 10.31 | 9 | 139212 | 308 | 64359203 |
Personality disorder | 14.86 | 10.31 | 32 | 139189 | 4679 | 64354832 |
Alanine aminotransferase increased | 14.80 | 10.31 | 211 | 139010 | 138820 | 64220691 |
Bronchiectasis | 14.76 | 10.31 | 6 | 139215 | 14134 | 64345377 |
Acute hepatic failure | 14.63 | 10.31 | 21 | 139200 | 26091 | 64333420 |
Bladder cancer | 14.49 | 10.31 | 3 | 139218 | 10971 | 64348540 |
Enterocolitis | 14.47 | 10.31 | 4 | 139217 | 12014 | 64347497 |
Electrolyte imbalance | 14.45 | 10.31 | 20 | 139201 | 25223 | 64334288 |
Lymphoma | 14.42 | 10.31 | 6 | 139215 | 13935 | 64345576 |
Body temperature decreased | 14.39 | 10.31 | 21 | 139200 | 25907 | 64333604 |
Restlessness | 14.31 | 10.31 | 140 | 139081 | 39645 | 64319866 |
Social anxiety disorder | 14.29 | 10.31 | 10 | 139211 | 440 | 64359071 |
Clostridium difficile infection | 14.20 | 10.31 | 36 | 139185 | 36127 | 64323384 |
Hypophosphataemia | 14.19 | 10.31 | 7 | 139214 | 14713 | 64344798 |
Sensitivity to weather change | 14.10 | 10.31 | 39 | 139182 | 6675 | 64352836 |
Pulmonary hypertension | 13.99 | 10.31 | 47 | 139174 | 43092 | 64316419 |
Vasoplegia syndrome | 13.99 | 10.31 | 23 | 139198 | 2744 | 64356767 |
Dizziness | 13.88 | 10.31 | 1093 | 138128 | 429070 | 63930441 |
Stoma site ulcer | 13.88 | 10.31 | 8 | 139213 | 250 | 64359261 |
Pseudomonas infection | 13.79 | 10.31 | 11 | 139210 | 17872 | 64341639 |
Pulmonary arterial hypertension | 13.63 | 10.31 | 21 | 139200 | 25346 | 64334165 |
Hypotonic urinary bladder | 13.56 | 10.31 | 5 | 139216 | 53 | 64359458 |
Pelvic pain | 13.55 | 10.31 | 53 | 139168 | 10857 | 64348654 |
Pre-existing condition improved | 13.50 | 10.31 | 31 | 139190 | 4731 | 64354780 |
Pupillary reflex impaired | 13.50 | 10.31 | 24 | 139197 | 3049 | 64356462 |
Carbon monoxide poisoning | 13.48 | 10.31 | 8 | 139213 | 264 | 64359247 |
Food craving | 13.47 | 10.31 | 16 | 139205 | 1408 | 64358103 |
Dysarthria | 13.35 | 10.31 | 191 | 139030 | 59215 | 64300296 |
Pharyngeal exudate | 13.35 | 10.31 | 3 | 139218 | 3 | 64359508 |
Ankle fracture | 13.32 | 10.31 | 65 | 139156 | 14645 | 64344866 |
Acute respiratory failure | 13.24 | 10.31 | 59 | 139162 | 49875 | 64309636 |
Faeces discoloured | 13.17 | 10.31 | 22 | 139199 | 25707 | 64333804 |
Cutaneous lupus erythematosus | 13.16 | 10.31 | 22 | 139199 | 2660 | 64356851 |
Gastrointestinal sounds abnormal | 13.15 | 10.31 | 31 | 139190 | 4812 | 64354699 |
Coagulopathy | 13.15 | 10.31 | 31 | 139190 | 31889 | 64327622 |
Pulmonary fibrosis | 13.14 | 10.31 | 28 | 139193 | 29850 | 64329661 |
Homeless | 13.12 | 10.31 | 6 | 139215 | 114 | 64359397 |
Flat affect | 13.05 | 10.31 | 18 | 139203 | 1839 | 64357672 |
Clonic convulsion | 13.02 | 10.31 | 14 | 139207 | 1105 | 64358406 |
Joint stiffness | 12.97 | 10.31 | 111 | 139110 | 30293 | 64329218 |
Ischaemic stroke | 12.94 | 10.31 | 27 | 139194 | 29008 | 64330503 |
Tachyphrenia | 12.90 | 10.31 | 18 | 139203 | 1858 | 64357653 |
Heavy menstrual bleeding | 12.89 | 10.31 | 56 | 139165 | 12021 | 64347490 |
Hepatic cirrhosis | 12.84 | 10.31 | 99 | 139122 | 26199 | 64333312 |
Dermatillomania | 12.80 | 10.31 | 7 | 139214 | 197 | 64359314 |
Blood potassium increased | 12.58 | 10.31 | 23 | 139198 | 25957 | 64333554 |
Blood pressure systolic abnormal | 12.56 | 10.31 | 3 | 139218 | 9939 | 64349572 |
Hyperammonaemia | 12.49 | 10.31 | 3 | 139218 | 9901 | 64349610 |
Initial insomnia | 12.48 | 10.31 | 34 | 139187 | 5770 | 64353741 |
Abscess sterile | 12.44 | 10.31 | 5 | 139216 | 68 | 64359443 |
Increased appetite | 12.36 | 10.31 | 49 | 139172 | 10097 | 64349414 |
Chills | 12.36 | 10.31 | 215 | 139006 | 137049 | 64222462 |
Hypoxia | 12.35 | 10.31 | 126 | 139095 | 88023 | 64271488 |
Non-alcoholic steatohepatitis | 12.35 | 10.31 | 18 | 139203 | 1934 | 64357577 |
Affect lability | 12.26 | 10.31 | 45 | 139176 | 8945 | 64350566 |
Persistent depressive disorder | 12.22 | 10.31 | 13 | 139208 | 1013 | 64358498 |
Hypervolaemia | 12.22 | 10.31 | 42 | 139179 | 38243 | 64321268 |
Cortisol increased | 12.17 | 10.31 | 9 | 139212 | 432 | 64359079 |
Binge drinking | 12.14 | 10.31 | 3 | 139218 | 6 | 64359505 |
Eczema | 12.13 | 10.31 | 29 | 139192 | 29691 | 64329820 |
Vaginal odour | 12.13 | 10.31 | 8 | 139213 | 319 | 64359192 |
Encephalitis | 12.08 | 10.31 | 6 | 139215 | 12565 | 64346946 |
Injection site abscess | 12.07 | 10.31 | 15 | 139206 | 1383 | 64358128 |
Right ventricular systolic pressure decreased | 12.06 | 10.31 | 5 | 139216 | 74 | 64359437 |
Accidental overdose | 12.03 | 10.31 | 118 | 139103 | 33439 | 64326072 |
Respiratory tract infection | 11.96 | 10.31 | 41 | 139180 | 37366 | 64322145 |
Face oedema | 11.92 | 10.31 | 22 | 139199 | 24739 | 64334772 |
Mental impairment | 11.91 | 10.31 | 68 | 139153 | 16275 | 64343236 |
Femur fracture | 11.90 | 10.31 | 36 | 139185 | 34099 | 64325412 |
Abulia | 11.89 | 10.31 | 12 | 139209 | 879 | 64358632 |
Disease recurrence | 11.89 | 10.31 | 32 | 139189 | 31478 | 64328033 |
Kidney transplant rejection | 11.76 | 10.31 | 3 | 139218 | 9508 | 64350003 |
Subdural haematoma | 11.75 | 10.31 | 27 | 139194 | 28027 | 64331484 |
Tongue spasm | 11.71 | 10.31 | 5 | 139216 | 80 | 64359431 |
Purpura | 11.64 | 10.31 | 12 | 139209 | 17234 | 64342277 |
Multiple fractures | 11.63 | 10.31 | 34 | 139187 | 6006 | 64353505 |
Peripheral sensory neuropathy | 11.60 | 10.31 | 5 | 139216 | 11373 | 64348138 |
Narcolepsy | 11.57 | 10.31 | 13 | 139208 | 1078 | 64358433 |
Oesophagitis | 11.54 | 10.31 | 18 | 139203 | 21612 | 64337899 |
Infusion site discomfort | 11.50 | 10.31 | 11 | 139210 | 755 | 64358756 |
Hyperlipidaemia | 11.50 | 10.31 | 87 | 139134 | 22889 | 64336622 |
Lower gastrointestinal haemorrhage | 11.49 | 10.31 | 8 | 139213 | 13931 | 64345580 |
Galactorrhoea | 11.48 | 10.31 | 23 | 139198 | 3196 | 64356315 |
Blood pressure diastolic decreased | 11.48 | 10.31 | 19 | 139202 | 22282 | 64337229 |
Urinary incontinence | 11.47 | 10.31 | 124 | 139097 | 36027 | 64323484 |
Hallucination, tactile | 11.44 | 10.31 | 9 | 139212 | 474 | 64359037 |
Ideas of reference | 11.44 | 10.31 | 6 | 139215 | 155 | 64359356 |
Panic disorder | 11.43 | 10.31 | 21 | 139200 | 2736 | 64356775 |
Ileus | 11.42 | 10.31 | 20 | 139201 | 22946 | 64336565 |
Tri-iodothyronine free decreased | 11.41 | 10.31 | 8 | 139213 | 353 | 64359158 |
Ejaculation failure | 11.41 | 10.31 | 8 | 139213 | 353 | 64359158 |
Tooth fracture | 11.35 | 10.31 | 47 | 139174 | 9880 | 64349631 |
Right ventricular failure | 11.33 | 10.31 | 18 | 139203 | 21453 | 64338058 |
Toxic optic neuropathy | 11.28 | 10.31 | 12 | 139209 | 935 | 64358576 |
Ventricular tachyarrhythmia | 11.28 | 10.31 | 7 | 139214 | 251 | 64359260 |
Bankruptcy | 11.24 | 10.31 | 4 | 139217 | 38 | 64359473 |
Renal tubular necrosis | 11.23 | 10.31 | 19 | 139202 | 22091 | 64337420 |
Blood urea increased | 11.21 | 10.31 | 53 | 139168 | 44100 | 64315411 |
Partial seizures | 11.19 | 10.31 | 38 | 139183 | 7269 | 64352242 |
Hyperuricaemia | 11.18 | 10.31 | 4 | 139217 | 10187 | 64349324 |
Concussion | 11.05 | 10.31 | 40 | 139181 | 7898 | 64351613 |
Reactive psychosis | 11.04 | 10.31 | 3 | 139218 | 10 | 64359501 |
Family stress | 11.03 | 10.31 | 10 | 139211 | 641 | 64358870 |
Muscular weakness | 10.98 | 10.31 | 201 | 139020 | 127137 | 64232374 |
Visuospatial deficit | 10.97 | 10.31 | 4 | 139217 | 41 | 64359470 |
Aggression | 10.93 | 10.31 | 150 | 139071 | 46082 | 64313429 |
Blood triglycerides increased | 10.93 | 10.31 | 74 | 139147 | 18792 | 64340719 |
Pain in jaw | 10.90 | 10.31 | 48 | 139173 | 40707 | 64318804 |
Cardiac failure chronic | 10.90 | 10.31 | 3 | 139218 | 9038 | 64350473 |
Feeling guilty | 10.83 | 10.31 | 11 | 139210 | 812 | 64358699 |
Hyperthyroidism | 10.81 | 10.31 | 14 | 139207 | 18165 | 64341346 |
Erythema induratum | 10.81 | 10.31 | 6 | 139215 | 174 | 64359337 |
Gastric haemorrhage | 10.77 | 10.31 | 8 | 139213 | 13473 | 64346038 |
Hypoaesthesia | 10.75 | 10.31 | 384 | 138837 | 138724 | 64220787 |
Dermatitis atopic | 10.73 | 10.31 | 25 | 139196 | 3851 | 64355660 |
Ventricular tachycardia | 10.63 | 10.31 | 117 | 139104 | 34148 | 64325363 |
Drug screen false positive | 10.63 | 10.31 | 12 | 139209 | 1000 | 64358511 |
Gastroenteritis | 10.60 | 10.31 | 31 | 139190 | 29680 | 64329831 |
Klebsiella infection | 10.46 | 10.31 | 8 | 139213 | 13273 | 64346238 |
Bone pain | 10.45 | 10.31 | 60 | 139161 | 47512 | 64311999 |
Petechiae | 10.42 | 10.31 | 15 | 139206 | 18611 | 64340900 |
Blood osmolarity decreased | 10.41 | 10.31 | 13 | 139208 | 1205 | 64358306 |
Ejection fraction abnormal | 10.39 | 10.31 | 14 | 139207 | 1399 | 64358112 |
Mass excision | 10.38 | 10.31 | 7 | 139214 | 290 | 64359221 |
Abscess | 10.36 | 10.31 | 16 | 139205 | 19288 | 64340223 |
Conduction disorder | 10.34 | 10.31 | 21 | 139200 | 2947 | 64356564 |
None
Source | Code | Description |
---|---|---|
ATC | A08AA62 | ALIMENTARY TRACT AND METABOLISM ANTIOBESITY PREPARATIONS, EXCL. DIET PRODUCTS ANTIOBESITY PREPARATIONS, EXCL. DIET PRODUCTS Centrally acting antiobesity products |
ATC | N06AX12 | NERVOUS SYSTEM PSYCHOANALEPTICS ANTIDEPRESSANTS Other antidepressants |
FDA MoA | N0000000102 | Norepinephrine Uptake Inhibitors |
FDA MoA | N0000000114 | Dopamine Uptake Inhibitors |
FDA PE | N0000009282 | Increased Dopamine Activity |
FDA PE | N0000009456 | Increased Norepinephrine Activity |
CHEBI has role | CHEBI:35469 | antidepressants |
CHEBI has role | CHEBI:35703 | Xenobiotic |
CHEBI has role | CHEBI:78298 | environmental contaminants |
FDA EPC | N0000180855 | Aminoketone |
MeSH PA | D000928 | Antidepressive Agents |
MeSH PA | D018687 | Antidepressive Agents, Second-Generation |
MeSH PA | D002491 | Central Nervous System Agents |
MeSH PA | D065690 | Cytochrome P-450 CYP2D6 Inhibitors |
MeSH PA | D065607 | Cytochrome P-450 Enzyme Inhibitors |
MeSH PA | D015259 | Dopamine Agents |
MeSH PA | D018765 | Dopamine Uptake Inhibitors |
MeSH PA | D004791 | Enzyme Inhibitors |
MeSH PA | D049990 | Membrane Transport Modulators |
MeSH PA | D065606 | Metabolic Side Effects of Drugs and Substances |
MeSH PA | D018377 | Neurotransmitter Agents |
MeSH PA | D014179 | Neurotransmitter Uptake Inhibitors |
MeSH PA | D011619 | Psychotropic Drugs |
MeSH PA | D000077444 | Smoking Cessation Agents |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Depressive disorder | indication | 35489007 | |
Nicotine dependence | indication | 56294008 | DOID:0050742 |
Seasonal affective disorder | indication | 247803002 | |
Major depressive disorder | indication | 370143000 | |
Smoking cessation assistance | indication | 384742004 | |
Obesity | indication | 414916001 | DOID:9970 |
Bipolar affective disorder, current episode depression | off-label use | 191627008 | DOID:3312 |
Attention deficit hyperactivity disorder | off-label use | 406506008 | |
Suicidal thoughts | contraindication | 6471006 | |
Alcoholism | contraindication | 7200002 | |
Mood swings | contraindication | 18963009 | |
Lowered convulsive threshold | contraindication | 19260006 | |
Cirrhosis of liver | contraindication | 19943007 | DOID:5082 |
Myocardial infarction | contraindication | 22298006 | DOID:5844 |
Feeling agitated | contraindication | 24199005 | |
Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
Anorexia nervosa | contraindication | 56882008 | DOID:8689 |
Hepatic failure | contraindication | 59927004 | |
Psychotic disorder | contraindication | 69322001 | |
Opioid dependence | contraindication | 75544000 | DOID:2559 |
Bulimia nervosa | contraindication | 78004001 | |
Hostile behavior | contraindication | 79351003 | |
Injury of head | contraindication | 82271004 | |
Weight loss | contraindication | 89362005 | |
Kidney disease | contraindication | 90708001 | DOID:557 |
Secondary malignant neoplasm of cerebrum | contraindication | 94248000 | |
Neoplasm of central nervous system | contraindication | 126951006 | DOID:3620 |
Seizure disorder | contraindication | 128613002 | |
Bipolar affective disorder, current episode manic | contraindication | 191618007 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Diabetic - poor control | contraindication | 268519009 | |
Alcohol withdrawal-induced convulsion | contraindication | 308742005 | |
Panic disorder | contraindication | 371631005 | DOID:594 |
Sedative Drug Dependence | contraindication | ||
Seizure due to Abrupt Benzodiazepine Withdrawal | contraindication | ||
Stimulant Drug Dependence | contraindication |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 7.87 | Basic |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
---|---|---|---|---|---|---|---|---|---|---|
90MG;8MG | CONTRAVE | NALPROPION | N200063 | Sept. 10, 2014 | RX | TABLET, EXTENDED RELEASE | ORAL | 11278544 | April 21, 2024 | FOR CHRONIC WEIGHT MANAGEMENT FOR TREATING OVERWEIGHT OR OBESITY |
90MG;8MG | CONTRAVE | NALPROPION | N200063 | Sept. 10, 2014 | RX | TABLET, EXTENDED RELEASE | ORAL | 7462626 | July 20, 2024 | FOR CHRONIC WEIGHT MANAGEMENT FOR TREATING OVERWEIGHT OR OBESITY |
90MG;8MG | CONTRAVE | NALPROPION | N200063 | Sept. 10, 2014 | RX | TABLET, EXTENDED RELEASE | ORAL | 8815889 | July 20, 2024 | FOR EFFECT ON BLOOD GLUCOSE PARAMETERS IN PATIENTS WITH INSULIN RESISTANCE |
174MG | APLENZIN | BAUSCH | N022108 | April 23, 2008 | RX | TABLET, EXTENDED RELEASE | ORAL | 7569610 | June 27, 2026 | TREATMENT OF MAJOR DEPRESSIVE DISORDER BY DOSING AT INTERVALS OF 24 HOURS |
348MG | APLENZIN | BAUSCH | N022108 | April 23, 2008 | RX | TABLET, EXTENDED RELEASE | ORAL | 7569610 | June 27, 2026 | TREATMENT OF MAJOR DEPRESSIVE DISORDER BY DOSING AT INTERVALS OF 24 HOURS |
522MG | APLENZIN | BAUSCH | N022108 | April 23, 2008 | RX | TABLET, EXTENDED RELEASE | ORAL | 7569610 | June 27, 2026 | TREATMENT OF MAJOR DEPRESSIVE DISORDER BY DOSING AT INTERVALS OF 24 HOURS |
90MG;8MG | CONTRAVE | NALPROPION | N200063 | Sept. 10, 2014 | RX | TABLET, EXTENDED RELEASE | ORAL | 9107837 | June 4, 2027 | USE OF NALTREXONE AND BUPROPION IN EXTENDED-RELEASE FORM FOR CHRONIC WEIGHT MANAGEMENT FOR TREATING OVERWEIGHT OR OBESITY |
90MG;8MG | CONTRAVE | NALPROPION | N200063 | Sept. 10, 2014 | RX | TABLET, EXTENDED RELEASE | ORAL | 10307376 | Nov. 8, 2027 | USE OF NALTREXONE AND BUPROPION BASED ON AN ESCALATING DOSE SCHEDULE |
90MG;8MG | CONTRAVE | NALPROPION | N200063 | Sept. 10, 2014 | RX | TABLET, EXTENDED RELEASE | ORAL | 8318788 | Nov. 8, 2027 | USE OF NALTREXONE AND BUPROPION IN A LAYERED FORMULATION FOR CHRONIC WEIGHT MANAGEMENT FOR AFFECTING WEIGHT LOSS |
90MG;8MG | CONTRAVE | NALPROPION | N200063 | Sept. 10, 2014 | RX | TABLET, EXTENDED RELEASE | ORAL | 8722085 | Nov. 8, 2027 | USE OF NALTREXONE AND BUPROPION BASED ON AN ESCALATING DOSE SCHEDULE |
90MG;8MG | CONTRAVE | NALPROPION | N200063 | Sept. 10, 2014 | RX | TABLET, EXTENDED RELEASE | ORAL | 9125868 | Nov. 8, 2027 | USE OF NALTREXONE AND BUPROPION BASED ON AN ESCALATING DOSE SCHEDULE |
90MG;8MG | CONTRAVE | NALPROPION | N200063 | Sept. 10, 2014 | RX | TABLET, EXTENDED RELEASE | ORAL | 11324741 | May 29, 2029 | FOR CHRONIC WEIGHT MANAGEMENT FOR TREATING OVERWEIGHT OR OBESITY |
90MG;8MG | CONTRAVE | NALPROPION | N200063 | Sept. 10, 2014 | RX | TABLET, EXTENDED RELEASE | ORAL | 8916195 | Feb. 2, 2030 | USE OF NALTREXONE AND BUPROPION IN EXTENDED-RELEASE FORM FOR CHRONIC WEIGHT MANAGEMENT FOR TREATING OVERWEIGHT OR OBESITY |
90MG;8MG | CONTRAVE | NALPROPION | N200063 | Sept. 10, 2014 | RX | TABLET, EXTENDED RELEASE | ORAL | 11033543 | Jan. 10, 2031 | FOR CHRONIC WEIGHT MANAGEMENT FOR TREATING OVERWEIGHT OR OBESITY |
90MG;8MG | CONTRAVE | NALPROPION | N200063 | Sept. 10, 2014 | RX | TABLET, EXTENDED RELEASE | ORAL | 9248123 | Jan. 13, 2032 | USE OF NALTREXONE AND BUPROPION FOR CHRONIC WEIGHT MANAGEMENT FOR TREATING OVERWEIGHT OR OBESITY IN PATIENTS WITH MAJOR DEPRESSIVE DISORDER |
90MG;8MG | CONTRAVE | NALPROPION | N200063 | Sept. 10, 2014 | RX | TABLET, EXTENDED RELEASE | ORAL | 10403170 | June 5, 2033 | FOR CHRONIC WEIGHT MANAGEMENT FOR TREATING OVERWEIGHT OR OBESITY |
90MG;8MG | CONTRAVE | NALPROPION | N200063 | Sept. 10, 2014 | RX | TABLET, EXTENDED RELEASE | ORAL | 11139056 | June 5, 2033 | FOR CHRONIC WEIGHT MANAGEMENT FOR TREATING OVERWEIGHT OR OBESITY |
90MG;8MG | CONTRAVE | NALPROPION | N200063 | Sept. 10, 2014 | RX | TABLET, EXTENDED RELEASE | ORAL | 9633575 | June 25, 2033 | FOR CHRONIC WEIGHT MANAGEMENT FOR TREATING OVERWEIGHT OR OBESITY |
90MG;8MG | CONTRAVE | NALPROPION | N200063 | Sept. 10, 2014 | RX | TABLET, EXTENDED RELEASE | ORAL | 10231964 | July 2, 2034 | FOR CHRONIC WEIGHT MANAGEMENT FOR TREATING OVERWEIGHT OR OBESITY |
90MG;8MG | CONTRAVE | NALPROPION | N200063 | Sept. 10, 2014 | RX | TABLET, EXTENDED RELEASE | ORAL | 10828294 | July 2, 2034 | FOR CHRONIC WEIGHT MANAGEMENT FOR TREATING OVERWEIGHT OR OBESITY |
90MG;8MG | CONTRAVE | NALPROPION | N200063 | Sept. 10, 2014 | RX | TABLET, EXTENDED RELEASE | ORAL | 10835527 | July 2, 2034 | FOR CHRONIC WEIGHT MANAGEMENT FOR TREATING OVERWEIGHT OR OBESITY |
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Sodium-dependent dopamine transporter | Transporter | INHIBITOR | Kd | 6.28 | WOMBAT-PK | CHEMBL | |||
Sodium-dependent noradrenaline transporter | Transporter | INHIBITOR | Ki | 5.16 | CHEMBL | CHEMBL | |||
Cytochrome P450 2D6 | Enzyme | WOMBAT-PK | |||||||
Neuronal acetylcholine receptor subunit alpha-7 | Ion channel | IC50 | 4.30 | CHEMBL | |||||
Cytochrome P450 2C19 | Enzyme | IC50 | 5.70 | DRUG MATRIX | |||||
Neuronal acetylcholine receptor; alpha3/beta4 | Ion channel | IC50 | 5.74 | CHEMBL | |||||
Sodium-dependent serotonin transporter | Transporter | Kd | 5.04 | WOMBAT-PK | |||||
Neuronal acetylcholine receptor; alpha3/beta2 | Ion channel | IC50 | 6 | CHEMBL | |||||
Alpha-1A adrenergic receptor | GPCR | Ki | 4.80 | PDSP | |||||
Membrane-associated progesterone receptor component 1 | Membrane receptor | Ki | 5.85 | DRUG MATRIX | |||||
Sodium-dependent dopamine transporter | Transporter | IC50 | 5.91 | CHEMBL |
ID | Source |
---|---|
4019645 | VUID |
N0000147738 | NUI |
D00817 | KEGG_DRUG |
31677-93-7 | SECONDARY_CAS_RN |
905818-69-1 | SECONDARY_CAS_RN |
203204 | RXNORM |
C0085208 | UMLSCUI |
CHEBI:3219 | CHEBI |
CHEMBL894 | ChEMBL_ID |
DB01156 | DRUGBANK_ID |
CHEMBL1201735 | ChEMBL_ID |
CHEMBL1698 | ChEMBL_ID |
D016642 | MESH_DESCRIPTOR_UI |
444 | PUBCHEM_CID |
7135 | IUPHAR_LIGAND_ID |
3562 | INN_ID |
01ZG3TPX31 | UNII |
162122 | MMSL |
26259 | MMSL |
31548 | MMSL |
4307 | MMSL |
4319 | MMSL |
d00181 | MMSL |
001512 | NDDF |
004611 | NDDF |
012996 | NDDF |
387564004 | SNOMEDCT_US |
395733003 | SNOMEDCT_US |
431408005 | SNOMEDCT_US |
96199001 | SNOMEDCT_US |
4019483 | VANDF |
4019645 | VANDF |
4029878 | VANDF |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Bupropion Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0115-5445 | TABLET, FILM COATED, EXTENDED RELEASE | 200 mg | ORAL | ANDA | 30 sections |
Bupropion Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0115-6811 | TABLET, FILM COATED, EXTENDED RELEASE | 150 mg | ORAL | ANDA | 30 sections |
WELLBUTRINSR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0173-0135 | TABLET, FILM COATED | 150 mg | ORAL | NDA | 29 sections |
WELLBUTRINSR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0173-0135 | TABLET, FILM COATED | 150 mg | ORAL | NDA | 29 sections |
WELLBUTRINSR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0173-0722 | TABLET, FILM COATED | 200 mg | ORAL | NDA | 29 sections |
WELLBUTRINSR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0173-0722 | TABLET, FILM COATED | 200 mg | ORAL | NDA | 29 sections |
WELLBUTRINSR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0173-0947 | TABLET, FILM COATED | 100 mg | ORAL | NDA | 29 sections |
WELLBUTRINSR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0173-0947 | TABLET, FILM COATED | 100 mg | ORAL | NDA | 29 sections |
Bupropion Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0185-0410 | TABLET, EXTENDED RELEASE | 100 mg | ORAL | ANDA | 29 sections |
Bupropion Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0185-0410 | TABLET, EXTENDED RELEASE | 100 mg | ORAL | ANDA | 29 sections |
Bupropion Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0185-0415 | TABLET, EXTENDED RELEASE | 150 mg | ORAL | ANDA | 29 sections |
Bupropion Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0185-0415 | TABLET, EXTENDED RELEASE | 150 mg | ORAL | ANDA | 29 sections |
Bupropion Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0185-1111 | TABLET, EXTENDED RELEASE | 200 mg | ORAL | ANDA | 29 sections |
Bupropion Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0185-1111 | TABLET, EXTENDED RELEASE | 200 mg | ORAL | ANDA | 29 sections |
WELLBUTRINXL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0187-0730 | TABLET, EXTENDED RELEASE | 150 mg | ORAL | NDA | 28 sections |
WELLBUTRINXL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0187-0730 | TABLET, EXTENDED RELEASE | 150 mg | ORAL | NDA | 28 sections |
WELLBUTRINXL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0187-0731 | TABLET, EXTENDED RELEASE | 300 mg | ORAL | NDA | 28 sections |
WELLBUTRINXL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0187-0731 | TABLET, EXTENDED RELEASE | 300 mg | ORAL | NDA | 28 sections |
Aplenzin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0187-5810 | TABLET, EXTENDED RELEASE | 174 mg | ORAL | NDA | 29 sections |
Aplenzin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0187-5810 | TABLET, EXTENDED RELEASE | 174 mg | ORAL | NDA | 29 sections |
Aplenzin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0187-5811 | TABLET, EXTENDED RELEASE | 348 mg | ORAL | NDA | 29 sections |
Aplenzin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0187-5811 | TABLET, EXTENDED RELEASE | 348 mg | ORAL | NDA | 29 sections |
Aplenzin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0187-5812 | TABLET, EXTENDED RELEASE | 522 mg | ORAL | NDA | 29 sections |
Aplenzin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0187-5812 | TABLET, EXTENDED RELEASE | 522 mg | ORAL | NDA | 29 sections |
Bupropion Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0440-7200 | TABLET, FILM COATED, EXTENDED RELEASE | 150 mg | ORAL | ANDA | 28 sections |
Bupropion hydrochloride (XL) | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0527-2415 | TABLET, EXTENDED RELEASE | 150 mg | ORAL | ANDA | 21 sections |
Bupropion hydrochloride (XL) | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0527-2430 | TABLET, EXTENDED RELEASE | 300 mg | ORAL | ANDA | 21 sections |
Bupropion HydrochlorideXL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0591-3331 | TABLET, FILM COATED, EXTENDED RELEASE | 150 mg | ORAL | ANDA | 29 sections |
Bupropion HydrochlorideXL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0591-3331 | TABLET, FILM COATED, EXTENDED RELEASE | 150 mg | ORAL | ANDA | 29 sections |
Bupropion HydrochlorideSR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0591-3540 | TABLET, FILM COATED, EXTENDED RELEASE | 100 mg | ORAL | ANDA | 29 sections |