bupropion Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
anorexics 435 34911-55-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • bupropion
  • (+/-)-Bupropion
  • amfebutamon
  • amfebutamone
  • aplenzin
  • elontril
  • bupropion hydrochloride
  • bupropion hydrobromide
  • bupropion HCl
  • wellbutrin
A propiophenone-derived antidepressant and antismoking agent that inhibits the uptake of DOPAMINE.
  • Molecular weight: 239.74
  • Formula: C13H18ClNO
  • CLOGP: 3.21
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 1
  • TPSA: 29.10
  • ALOGS: -3.54
  • ROTB: 4

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.30 g O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 312 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 31.28 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Approvals:

DateAgencyCompanyOrphan
Dec. 30, 1985 FDA GLAXOSMITHKLINE

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 3269.81 9.93 2781 113367 143139 46426775
Toxicity to various agents 762.55 9.93 1647 114501 210119 46359795
Depression 561.95 9.93 1279 114869 168825 46401089
Overdose 435.37 9.93 852 115296 101127 46468787
Product substitution issue 409.02 9.93 322 115826 14709 46555205
Generalised tonic-clonic seizure 388.78 9.93 405 115743 26717 46543197
Seizure 385.79 9.93 907 115241 122147 46447767
Intentional overdose 385.72 9.93 627 115521 64317 46505597
Suicidal ideation 380.13 9.93 577 115571 55805 46514109
Anxiety 347.39 9.93 1118 115030 180839 46389075
Poisoning 324.28 9.93 273 115875 13721 46556193
Cardio-respiratory arrest 293.57 9.93 531 115617 59338 46510576
Respiratory arrest 250.73 9.93 362 115786 33454 46536460
Cardiac arrest 244.55 9.93 630 115518 89769 46480145
Electrocardiogram QRS complex prolonged 238.75 9.93 156 115992 5293 46564621
Suicide attempt 226.36 9.93 453 115695 54583 46515331
Agitation 208.88 9.93 440 115708 54975 46514939
Serotonin syndrome 195.40 9.93 270 115878 23950 46545964
Suspected suicide 193.44 9.93 129 116019 4532 46565382
Irritability 164.33 9.93 274 115874 28672 46541242
Temperature regulation disorder 164.07 9.93 103 116045 3257 46566657
Insomnia 161.59 9.93 824 115324 164100 46405814
Acute kidney injury 160.58 9.93 211 115937 235644 46334270
Status epilepticus 154.09 9.93 182 115966 13797 46556117
Tremor 153.59 9.93 632 115516 115007 46454907
Anaemia 149.70 9.93 254 115894 255525 46314389
Drug withdrawal syndrome 148.53 9.93 254 115894 27130 46542784
Mydriasis 148.32 9.93 156 115992 10397 46559517
Electrocardiogram QT prolonged 140.03 9.93 359 115789 50966 46518948
Neutropenia 138.66 9.93 93 116055 143111 46426803
Therapeutic response unexpected 136.46 9.93 181 115967 15435 46554479
Feeling abnormal 128.17 9.93 633 115515 124427 46445487
Thrombocytopenia 125.53 9.93 80 116068 126501 46443413
Pyrexia 124.34 9.93 448 115700 348354 46221560
Coeliac disease 119.19 9.93 116 116032 7045 46562869
Sinus tachycardia 115.03 9.93 199 115949 21450 46548464
Food allergy 109.24 9.93 109 116039 6824 46563090
Febrile neutropenia 108.10 9.93 50 116098 94577 46475337
White blood cell count abnormal 100.51 9.93 91 116057 5041 46564873
Cardiac failure 99.78 9.93 37 116111 79911 46490003
Pneumonia 98.65 9.93 542 115606 375778 46194136
Pancytopenia 98.63 9.93 44 116104 85014 46484900
Treatment failure 94.81 9.93 57 116091 93030 46476884
Anger 93.89 9.93 131 116017 11721 46558193
Product complaint 93.26 9.93 132 116016 11969 46557945
Pemphigus 92.11 9.93 5 116143 45269 46524645
Diarrhoea 90.38 9.93 924 115224 558678 46011236
Hyperhidrosis 87.18 9.93 446 115702 88862 46481052
Weight increased 87.02 9.93 703 115445 163770 46406144
General physical health deterioration 84.52 9.93 98 116050 115671 46454243
Malignant neoplasm progression 82.80 9.93 29 116119 64897 46505017
Hyponatraemia 82.73 9.93 78 116070 101254 46468660
Drug abuse 80.54 9.93 342 115806 63066 46506848
Headache 79.16 9.93 1647 114501 476705 46093209
Withdrawal syndrome 77.79 9.93 152 115996 17982 46551932
Dyspnoea 77.23 9.93 866 115282 514682 46055232
Postmortem blood drug level increased 73.41 9.93 31 116117 414 46569500
Atrial fibrillation 73.15 9.93 90 116058 103500 46466414
Exposure via ingestion 72.91 9.93 64 116084 3403 46566511
Crying 72.89 9.93 162 115986 20979 46548935
Myoclonus 72.44 9.93 129 116019 14223 46555691
Renal impairment 72.34 9.93 48 116100 74324 46495590
Panic attack 71.93 9.93 157 115991 20085 46549829
Product residue present 70.52 9.93 66 116082 3816 46566098
Tardive dyskinesia 69.89 9.93 90 116058 7453 46562461
Mental status changes 69.68 9.93 231 115917 37857 46532057
Sepsis 68.15 9.93 148 116000 135866 46434048
Systemic lupus erythematosus 67.65 9.93 39 116109 65141 46504773
Sympathomimetic effect 66.72 9.93 17 116131 33 46569881
Disturbance in attention 66.52 9.93 201 115947 31359 46538555
Maternal exposure during pregnancy 66.39 9.93 95 116053 102454 46467460
Postictal state 65.69 9.93 37 116111 954 46568960
Hand deformity 64.07 9.93 6 116142 34568 46535346
Haemoglobin decreased 63.21 9.93 142 116006 128807 46441107
Immunodeficiency 62.59 9.93 115 116033 12991 46556923
Pulseless electrical activity 62.50 9.93 83 116065 7084 46562830
Bone marrow failure 61.23 9.93 3 116145 29666 46540248
Cholecystitis chronic 60.39 9.93 100 116048 10399 46559515
Platelet count decreased 59.62 9.93 98 116050 99926 46469988
Memory impairment 59.33 9.93 362 115786 76975 46492939
Hyperkalaemia 59.14 9.93 26 116122 50683 46519231
Hepatocellular injury 57.83 9.93 4 116144 29518 46540396
Cerebral venous thrombosis 56.62 9.93 45 116103 2082 46567832
Mental disorder 56.18 9.93 152 115996 22273 46547641
Product odour abnormal 55.91 9.93 35 116113 1101 46568813
Septic shock 55.45 9.93 38 116110 57855 46512059
Joint swelling 54.68 9.93 220 115928 165853 46404061
Bursitis 54.30 9.93 139 116009 19703 46550211
Swelling 54.06 9.93 146 116002 124365 46445549
Migraine 53.85 9.93 328 115820 69698 46500216
Pleural effusion 53.53 9.93 77 116071 82875 46487039
Peripheral swelling 52.29 9.93 209 115939 157862 46412052
Brain injury 50.24 9.93 69 116079 6081 46563833
Death 49.95 9.93 564 115584 334984 46234930
Infection 49.86 9.93 168 115980 133424 46436490
Mood altered 49.80 9.93 104 116044 12903 46557011
Feeling jittery 49.33 9.93 94 116054 10914 46559000
Sleep-related eating disorder 49.03 9.93 26 116122 593 46569321
Disease progression 48.54 9.93 96 116052 91204 46478710
Cardiogenic shock 48.22 9.93 118 116030 16266 46553648
Hepatic function abnormal 48.15 9.93 13 116135 34408 46535506
Pupil fixed 47.10 9.93 37 116111 1683 46568231
Drug hypersensitivity 47.07 9.93 860 115288 242965 46326949
Areflexia 46.65 9.93 47 116101 2976 46566938
Leukopenia 46.55 9.93 61 116087 68282 46501632
Intentional product misuse 46.40 9.93 236 115912 46892 46523022
Renal failure 45.78 9.93 138 116010 113456 46456458
Neutrophil count decreased 45.03 9.93 26 116122 43400 46526514
Multiple organ dysfunction syndrome 44.34 9.93 38 116110 51672 46518242
Gastrointestinal haemorrhage 44.09 9.93 78 116070 77295 46492619
Glossodynia 44.01 9.93 28 116120 44345 46525569
Sleep apnoea syndrome 43.63 9.93 138 116010 22063 46547851
White blood cell count decreased 42.65 9.93 140 116008 112091 46457823
Hypokalaemia 42.26 9.93 98 116050 87926 46481988
Infusion related reaction 42.20 9.93 121 116027 101087 46468827
Cholestasis 41.93 9.93 8 116140 26885 46543029
Mucosal inflammation 40.90 9.93 23 116125 38953 46530961
Major depression 40.21 9.93 65 116083 6625 46563289
Multiple sclerosis relapse 40.12 9.93 209 115939 41916 46527998
Infarction 39.66 9.93 38 116110 2263 46567651
Amnesia 39.27 9.93 206 115942 41425 46528489
Depressed mood 37.95 9.93 174 115974 33145 46536769
Affect lability 37.82 9.93 70 116078 7950 46561964
Thinking abnormal 37.02 9.93 78 116070 9736 46560178
Drug screen positive 36.95 9.93 47 116101 3844 46566070
Bipolar disorder 36.85 9.93 65 116083 7112 46562802
Rash 36.75 9.93 645 115503 355867 46214047
Anti-cyclic citrullinated peptide antibody positive 36.34 9.93 3 116145 19142 46550772
Liver disorder 36.26 9.93 24 116124 37222 46532692
Choreoathetosis 36.24 9.93 19 116129 423 46569491
Toxic epidermal necrolysis 36.10 9.93 6 116142 22272 46547642
Drug titration error 35.95 9.93 21 116127 581 46569333
Hyperreflexia 35.68 9.93 54 116094 5200 46564714
Epistaxis 35.58 9.93 66 116082 64239 46505675
Emotional distress 35.45 9.93 161 115987 30546 46539368
Automatism 35.42 9.93 11 116137 55 46569859
Abnormal dreams 34.57 9.93 78 116070 10201 46559713
Unresponsive to stimuli 34.43 9.93 165 115983 32009 46537905
Gamma-glutamyltransferase increased 34.37 9.93 18 116130 31722 46538192
Impaired work ability 34.04 9.93 88 116060 12548 46557366
Cerebral haemorrhage 33.95 9.93 14 116134 28357 46541557
Lower respiratory tract infection 33.73 9.93 53 116095 55036 46514878
Lung disorder 33.41 9.93 35 116113 43269 46526645
Feeling of despair 33.39 9.93 31 116117 1774 46568140
Arthropathy 33.33 9.93 104 116044 84596 46485318
Brain death 33.19 9.93 38 116110 2785 46567129
Drug reaction with eosinophilia and systemic symptoms 33.13 9.93 16 116132 29532 46540382
Nervousness 32.65 9.93 149 115999 28326 46541588
Peritonitis 32.64 9.93 6 116142 20708 46549206
Hypoglycaemia 32.60 9.93 53 116095 54296 46515618
Off label use 32.52 9.93 709 115439 379132 46190782
Sleep paralysis 32.35 9.93 18 116130 453 46569461
Malaise 32.00 9.93 606 115542 330626 46239288
C-reactive protein increased 31.66 9.93 61 116087 58529 46511385
Rubber sensitivity 31.12 9.93 29 116119 1667 46568247
Hallucination 31.12 9.93 222 115926 49729 46520185
Decreased appetite 31.11 9.93 320 115828 193516 46376398
Stress 30.90 9.93 227 115921 51324 46518590
International normalised ratio increased 30.75 9.93 43 116105 46840 46523074
Mania 30.74 9.93 77 116071 10769 46559145
Nightmare 30.65 9.93 101 116047 16497 46553417
Libido decreased 30.51 9.93 35 116113 2570 46567344
Electroencephalogram abnormal 30.49 9.93 42 116106 3712 46566202
Economic problem 30.43 9.93 31 116117 1989 46567925
Jaundice 30.29 9.93 17 116131 28828 46541086
Cough 30.03 9.93 398 115750 229851 46340063
Akathisia 29.91 9.93 62 116086 7652 46562262
Bruxism 29.53 9.93 37 116111 2980 46566934
Hepatic failure 29.33 9.93 24 116124 33392 46536522
Plasma cell myeloma 28.97 9.93 41 116107 44437 46525477
Vision blurred 28.68 9.93 314 115834 79394 46490520
Muscle twitching 28.64 9.93 91 116057 14581 46555333
Herpes zoster 28.39 9.93 81 116067 67791 46502123
Oedema 28.08 9.93 80 116068 66991 46502923
Restless legs syndrome 28.00 9.93 95 116053 15748 46554166
Central nervous system necrosis 27.96 9.93 11 116137 121 46569793
Drug intolerance 27.80 9.93 233 115915 146816 46423098
Ventricular tachycardia 27.62 9.93 99 116049 16868 46553046
Mood swings 27.46 9.93 96 116052 16156 46553758
Haematemesis 27.45 9.93 19 116129 28787 46541127
Tachyphrenia 27.44 9.93 24 116124 1270 46568644
Gambling disorder 27.40 9.93 24 116124 1272 46568642
Syncope 27.31 9.93 151 115997 104652 46465262
Blood creatinine increased 27.19 9.93 98 116050 76305 46493609
Decreased interest 26.71 9.93 36 116112 3116 46566798
Ascites 26.64 9.93 31 116117 36553 46533361
Apathy 26.53 9.93 57 116091 7211 46562703
Somnolence 26.39 9.93 541 115607 155980 46413934
Hostility 26.38 9.93 24 116124 1338 46568576
Osteonecrosis of jaw 26.32 9.93 28 116120 34374 46535540
Accidental exposure to product by child 26.20 9.93 22 116126 1101 46568813
Myelodysplastic syndrome 25.97 9.93 4 116144 15707 46554207
Nausea 25.90 9.93 2014 114134 685440 45884474
Injury 25.89 9.93 193 115955 43834 46526080
Rash erythematous 25.83 9.93 160 115988 34190 46535724
Pre-existing condition improved 25.47 9.93 53 116095 6559 46563355
Tachycardia 25.37 9.93 368 115780 99254 46470660
Agranulocytosis 24.89 9.93 12 116136 22173 46547741
Thalamic infarction 24.85 9.93 16 116132 529 46569385
Haemorrhage 24.82 9.93 63 116085 54806 46515108
Posterior reversible encephalopathy syndrome 24.70 9.93 4 116144 15137 46554777
Binge eating 24.68 9.93 14 116134 366 46569548
C-reactive protein abnormal 24.65 9.93 11 116137 21259 46548655
Rash maculo-papular 24.49 9.93 20 116128 27854 46542060
Melaena 24.31 9.93 20 116128 27752 46542162
Hypercalcaemia 24.20 9.93 11 116137 21035 46548879
Polycystic ovaries 24.12 9.93 23 116125 1361 46568553
Affective disorder 23.94 9.93 43 116105 4772 46565142
Hepatitis 23.78 9.93 27 116121 32188 46537726
Large intestine anastomosis 23.60 9.93 7 116141 29 46569885
Interstitial lung disease 23.59 9.93 63 116085 53886 46516028
Erythema dyschromicum perstans 23.50 9.93 8 116140 56 46569858
Anorgasmia 23.49 9.93 16 116132 582 46569332
Attention deficit hyperactivity disorder 23.47 9.93 28 116120 2144 46567770
Tinnitus 23.44 9.93 133 116015 27540 46542374
Adrenergic syndrome 23.41 9.93 7 116141 30 46569884
Impulse-control disorder 23.39 9.93 17 116131 687 46569227
Lactic acidosis 23.36 9.93 30 116118 33879 46536035
Drug eruption 23.23 9.93 12 116136 21317 46548597
Dysphemia 23.21 9.93 29 116119 2329 46567585
Premature delivery 23.18 9.93 13 116135 22056 46547858
Blood lactate dehydrogenase increased 23.13 9.93 11 116137 20489 46549425
Hallucination, auditory 23.13 9.93 69 116079 10687 46559227
Product quality issue 23.12 9.93 160 115988 35488 46534426
Corneal reflex decreased 23.00 9.93 10 116138 144 46569770
Paranoia 22.80 9.93 68 116080 10529 46559385
Drug dependence 22.71 9.93 104 116044 19797 46550117
Arthralgia 22.59 9.93 713 115435 363890 46206024
Post-traumatic stress disorder 22.54 9.93 38 116110 4010 46565904
Gastrointestinal sounds abnormal 22.36 9.93 35 116113 3471 46566443
Oedema peripheral 22.32 9.93 272 115876 159434 46410480
Upper gastrointestinal haemorrhage 22.16 9.93 7 116141 16731 46553183
Anhedonia 21.94 9.93 66 116082 10269 46559645
Oppositional defiant disorder 21.91 9.93 7 116141 39 46569875
Urine osmolarity increased 21.81 9.93 9 116139 113 46569801
Obsessive-compulsive disorder 21.77 9.93 33 116115 3182 46566732
Red blood cell sedimentation rate abnormal 21.41 9.93 4 116144 13645 46556269
Hypocalcaemia 21.40 9.93 21 116127 26764 46543150
Impaired driving ability 21.36 9.93 38 116110 4186 46565728
Respiratory failure 21.35 9.93 143 116005 94673 46475241
Solar urticaria 21.34 9.93 7 116141 43 46569871
Asthma 21.31 9.93 333 115815 91209 46478705
Bronchial neoplasm 21.26 9.93 11 116137 238 46569676
Urinary tract infection 21.23 9.93 403 115745 219863 46350051
Food craving 21.21 9.93 20 116128 1167 46568747
Product use issue 21.18 9.93 143 116005 94501 46475413
Alopecia 21.06 9.93 281 115867 162133 46407781
Dyspnoea exertional 21.04 9.93 60 116088 50229 46519685
Dizziness 20.88 9.93 1041 115107 339373 46230541
Toxic skin eruption 20.83 9.93 3 116145 12384 46557530
Hypomagnesaemia 20.70 9.93 15 116133 22195 46547719
Priapism 20.63 9.93 5 116143 7 46569907
Hypotonic urinary bladder 20.63 9.93 5 116143 7 46569907
Urine sodium increased 20.58 9.93 8 116140 85 46569829
Vertigo 20.57 9.93 209 115939 51839 46518075
Asthenia 20.57 9.93 603 115545 310472 46259442
Nicotine dependence 20.56 9.93 14 116134 509 46569405
Self esteem decreased 20.11 9.93 14 116134 528 46569386
Neoplasm progression 20.10 9.93 22 116126 26661 46543253
Pericarditis 20.01 9.93 18 116130 23909 46546005
Blood bilirubin increased 19.88 9.93 34 116114 34150 46535764
Cardiac failure congestive 19.86 9.93 140 116008 91610 46478304
Liver function test abnormal 19.79 9.93 55 116093 46432 46523482
Stomatitis 19.70 9.93 95 116053 68202 46501712
Sexual dysfunction 19.69 9.93 27 116121 2376 46567538
Cardiomyopathy acute 19.69 9.93 10 116138 208 46569706
Gallbladder disorder 19.64 9.93 91 116057 17407 46552507
Caput succedaneum 19.53 9.93 5 116143 10 46569904
Neuropathy peripheral 19.52 9.93 139 116009 90754 46479160
Road traffic accident 19.50 9.93 113 116035 23578 46546336
Dyskinesia 19.45 9.93 131 116017 28794 46541120
Nasopharyngitis 19.41 9.93 268 115880 153730 46416184
Emotional disorder 19.29 9.93 71 116077 12253 46557661
Cerebrovascular accident 19.13 9.93 160 115988 100879 46469035
Anticholinergic syndrome 19.05 9.93 23 116125 1783 46568131
Fluid overload 18.78 9.93 24 116124 27161 46542753
Pneumonitis 18.70 9.93 26 116122 28394 46541520
Anuria 18.69 9.93 3 116145 11428 46558486
Euphoric mood 18.55 9.93 36 116112 4236 46565678
Hunger 18.50 9.93 34 116114 3841 46566073
Mobility decreased 18.24 9.93 83 116065 60511 46509403
Biliary dyskinesia 18.13 9.93 28 116120 2745 46567169
Liver function test increased 18.11 9.93 18 116130 22808 46547106
Heart rate decreased 18.04 9.93 32 116116 31691 46538223
Dysphoria 17.93 9.93 37 116111 4552 46565362
Bronchial haemorrhage 17.92 9.93 11 116137 334 46569580
Wound infection fungal 17.87 9.93 7 116141 76 46569838
Ventricular tachyarrhythmia 17.79 9.93 7 116141 77 46569837
Multiple sclerosis 17.72 9.93 114 116034 24677 46545237
Abdominal discomfort 17.67 9.93 267 115881 150898 46419016
Oscillopsia 17.53 9.93 8 116140 130 46569784
Disseminated intravascular coagulation 17.50 9.93 13 116135 18992 46550922
Balance disorder 17.49 9.93 241 115907 64280 46505634
Bone pain 17.45 9.93 59 116089 46831 46523083
Blister 17.41 9.93 55 116093 44576 46525338
Pulmonary hypertension 17.32 9.93 40 116108 35953 46533961
Metastases to liver 17.27 9.93 14 116134 19571 46550343
Tongue biting 17.12 9.93 19 116129 1345 46568569
Parkinsonism 17.10 9.93 51 116097 7897 46562017
Polyneuropathy 17.05 9.93 4 116144 11640 46558274
Synovitis 17.02 9.93 86 116062 60989 46508925
Sensitisation 16.98 9.93 14 116134 683 46569231
Iron deficiency anaemia 16.86 9.93 11 116137 17195 46552719
Psoriasis 16.82 9.93 282 115866 78322 46491592
Restlessness 16.81 9.93 115 116033 25409 46544505
Cerebral infarction 16.80 9.93 20 116128 23346 46546568
Somnambulism 16.69 9.93 38 116110 4999 46564915
Dysgraphia 16.61 9.93 27 116121 2765 46567149
Pupillary reflex impaired 16.59 9.93 23 116125 2045 46567869
Supraventricular tachycardia 16.39 9.93 71 116077 13199 46556715
Hepatotoxicity 16.34 9.93 23 116125 24986 46544928
Mucosal dryness 16.21 9.93 24 116124 2266 46567648
Sedation 16.16 9.93 105 116043 22805 46547109
Right ventricular systolic pressure decreased 16.10 9.93 5 116143 25 46569889
Dystonia 16.09 9.93 63 116085 11194 46558720
Narcolepsy 16.05 9.93 17 116131 1142 46568772
Metastases to bone 16.03 9.93 12 116136 17464 46552450
Homicidal ideation 15.91 9.93 21 116127 1781 46568133
Dermatillomania 15.85 9.93 8 116140 164 46569750
Pulmonary arterial hypertension 15.82 9.93 25 116123 25903 46544011
Tearfulness 15.75 9.93 33 116115 4102 46565812
Libido increased 15.73 9.93 14 116134 758 46569156
Nasal turbinate hypertrophy 15.73 9.93 11 116137 418 46569496
Mental impairment 15.66 9.93 67 116081 12389 46557525
Choroidal effusion 15.61 9.93 11 116137 423 46569491
Loss of libido 15.59 9.93 18 116130 1331 46568583
Acute myeloid leukaemia 15.58 9.93 10 116138 15768 46554146
Clostridium difficile infection 15.51 9.93 24 116124 25079 46544835
Pruritus 15.45 9.93 472 115676 241880 46328034
Haemoglobin urine 15.38 9.93 7 116141 113 46569801
Compulsive shopping 15.38 9.93 14 116134 781 46569133
Haematuria 15.36 9.93 27 116121 26831 46543083
Cardiotoxicity 15.29 9.93 44 116104 6678 46563236
Palmar-plantar erythrodysaesthesia syndrome 15.25 9.93 17 116131 20434 46549480
Orgasmic sensation decreased 15.00 9.93 3 116145 0 46569914
Depressive symptom 14.97 9.93 26 116122 2810 46567104
Acute myocardial infarction 14.95 9.93 36 116112 31888 46538026
Femur fracture 14.85 9.93 45 116103 36952 46532962
Pain in extremity 14.78 9.93 511 115637 258169 46311745
Convulsive threshold lowered 14.73 9.93 10 116138 362 46569552
Ejection fraction 14.65 9.93 12 116136 580 46569334
Drug resistance 14.60 9.93 13 116135 17355 46552559
Electrocardiogram QRS complex shortened 14.49 9.93 10 116138 372 46569542
Bipolar II disorder 14.46 9.93 9 116139 280 46569634
Pallor 14.45 9.93 22 116126 23144 46546770
Breast cancer metastatic 14.45 9.93 8 116140 13670 46556244
Infusion site scar 14.42 9.93 8 116140 200 46569714
Haemangioma congenital 14.42 9.93 11 116137 479 46569435
Pancreatitis acute 14.23 9.93 25 116123 24847 46545067
Drug screen false positive 14.21 9.93 14 116134 863 46569051
Multiple fractures 14.21 9.93 38 116110 5529 46564385
Posturing 14.20 9.93 11 116137 490 46569424
Energy increased 14.13 9.93 22 116126 2172 46567742
Uterine perforation 14.12 9.93 45 116103 7222 46562692
Aggression 14.11 9.93 101 116047 22643 46547271
Abnormal behaviour 13.94 9.93 95 116053 20963 46548951
Anaphylactic shock 13.90 9.93 18 116130 20256 46549658
Hallucinations, mixed 13.84 9.93 30 116118 3819 46566095
Essential tremor 13.82 9.93 13 116135 756 46569158
Autonomic nervous system imbalance 13.81 9.93 23 116125 2403 46567511
Hypoxic-ischaemic encephalopathy 13.80 9.93 31 116117 4042 46565872
Snoring 13.74 9.93 28 116120 3414 46566500
Product coating issue 13.69 9.93 5 116143 44 46569870
Thrombophlebitis superficial 13.64 9.93 35 116113 4968 46564946
Muscle rigidity 13.63 9.93 55 116093 9906 46560008
Bipolar I disorder 13.63 9.93 18 116130 1528 46568386
Chronic fatigue syndrome 13.59 9.93 15 116133 1056 46568858
Premature baby 13.57 9.93 15 116133 18097 46551817
Pneumothorax 13.48 9.93 10 116138 14619 46555295
Abscess sterile 13.40 9.93 5 116143 47 46569867
Diverticulitis 13.40 9.93 40 116108 32999 46536915
Haematoma 13.35 9.93 38 116110 31834 46538080
Dehydration 13.26 9.93 299 115849 159241 46410673
Bezoar 13.25 9.93 17 116131 1402 46568512
Upper respiratory tract infection 13.22 9.93 227 115921 63329 46506585
Poor personal hygiene 13.13 9.93 9 116139 331 46569583
Lethargy 13.01 9.93 189 115959 50982 46518932
Brain stem syndrome 12.89 9.93 9 116139 341 46569573
Staring 12.78 9.93 17 116131 1453 46568461
Corneal oedema 12.75 9.93 18 116130 1628 46568286
Cortisol increased 12.73 9.93 9 116139 348 46569566
Patient dissatisfaction with treatment 12.71 9.93 5 116143 55 46569859
Partner stress 12.69 9.93 7 116141 173 46569741
Decorticate posture 12.66 9.93 9 116139 351 46569563
Hypertonic bladder 12.66 9.93 25 116123 2979 46566935
Generalised anxiety disorder 12.63 9.93 18 116130 1642 46568272
Peritonitis bacterial 12.62 9.93 3 116145 8650 46561264
Shock haemorrhagic 12.56 9.93 3 116145 8621 46561293
Skin necrosis 12.51 9.93 3 116145 8601 46561313
Joint dislocation 12.43 9.93 58 116090 11128 46558786
Panic reaction 12.41 9.93 28 116120 3661 46566253
Accidental poisoning 12.39 9.93 11 116137 594 46569320
Fibromyalgia 12.36 9.93 142 116006 36321 46533593
Dissociation 12.33 9.93 19 116129 1858 46568056
Foot deformity 12.32 9.93 73 116075 15352 46554562
Executive dysfunction 12.21 9.93 6 116142 116 46569798
Clostridium difficile colitis 12.18 9.93 17 116131 18536 46551378
Inappropriate schedule of product administration 12.04 9.93 228 115920 64785 46505129
Social anxiety disorder 12.04 9.93 9 116139 380 46569534
Musculoskeletal pain 11.97 9.93 114 116034 70014 46499900
Angina pectoris 11.91 9.93 31 116117 26744 46543170
Anti-neutrophil cytoplasmic antibody positive vasculitis 11.90 9.93 19 116129 1916 46567998
Gastrointestinal disorder 11.89 9.93 93 116055 59483 46510431
Rectal haemorrhage 11.75 9.93 52 116096 38203 46531711
Hypohidrosis 11.75 9.93 4 116144 28 46569886
Oesophageal pain 11.75 9.93 22 116126 2521 46567393
Dry mouth 11.73 9.93 197 115951 54729 46515185
Hypertensive crisis 11.67 9.93 10 116138 13605 46556309
Blood triglycerides increased 11.59 9.93 59 116089 11724 46558190
Gastroenteritis 11.59 9.93 27 116121 24192 46545722
Carbon monoxide poisoning 11.57 9.93 7 116141 207 46569707
Obsessive thoughts 11.56 9.93 10 116138 521 46569393
Haemolytic anaemia 11.54 9.93 5 116143 9837 46560077
Psychomotor hyperactivity 11.54 9.93 51 116097 9562 46560352
Acute lung injury 11.52 9.93 15 116133 1256 46568658
Vocal cord thickening 11.51 9.93 4 116144 30 46569884
Nephrectomy 11.50 9.93 10 116138 525 46569389
Aphasia 11.42 9.93 115 116033 28452 46541462
Serum sickness-like reaction 11.37 9.93 9 116139 414 46569500
Right ventricular failure 11.33 9.93 14 116134 16079 46553835
Colitis 11.33 9.93 51 116097 37296 46532618
Rheumatoid factor positive 11.31 9.93 21 116127 20440 46549474
Skin ulcer 11.30 9.93 42 116106 32416 46537498
Homeless 11.29 9.93 4 116144 32 46569882
Bankruptcy 11.29 9.93 4 116144 32 46569882
Wheezing 11.28 9.93 82 116066 53304 46516610
Eosinophilia 11.28 9.93 19 116129 19198 46550716
Distractibility 11.28 9.93 8 116140 311 46569603
Gaze palsy 11.27 9.93 15 116133 1283 46568631
Flat affect 11.27 9.93 15 116133 1283 46568631
Hyperbilirubinaemia 11.18 9.93 6 116142 10432 46559482
Thermal burn 11.17 9.93 32 116116 4845 46565069
Treatment noncompliance 11.09 9.93 118 116030 29613 46540301
Psychotic disorder 11.02 9.93 95 116053 22526 46547388
Endometrial ablation 11.02 9.93 11 116137 689 46569225
Initial insomnia 10.97 9.93 30 116118 4422 46565492
Tension 10.93 9.93 23 116125 2869 46567045
Impulsive behaviour 10.90 9.93 16 116132 1499 46568415
Disorientation 10.87 9.93 140 116008 36778 46533136
Fluid retention 10.87 9.93 183 115965 50863 46519051
Blood pressure orthostatic abnormal 10.86 9.93 3 116145 9 46569905
Tuberculosis 10.85 9.93 6 116142 10259 46559655
Increased appetite 10.82 9.93 46 116102 8481 46561433
Drug-induced liver injury 10.81 9.93 30 116118 25338 46544576
Galactorrhoea 10.80 9.93 27 116121 3770 46566144
Impatience 10.80 9.93 8 116140 333 46569581
Extrapyramidal disorder 10.79 9.93 56 116092 11212 46558702
Pain in jaw 10.70 9.93 54 116094 38318 46531596
Blindness cortical 10.66 9.93 9 116139 454 46569460
Hepatic encephalopathy 10.64 9.93 6 116142 10151 46559763
Motor dysfunction 10.61 9.93 41 116107 7241 46562673
Osteonecrosis 10.56 9.93 31 116117 25713 46544201
Mouth ulceration 10.51 9.93 33 116115 26799 46543115
Bronchiectasis 10.51 9.93 5 116143 9311 46560603
Angle closure glaucoma 10.50 9.93 19 116129 2120 46567794
Ankle operation 10.50 9.93 14 116134 1199 46568715
Tunnel vision 10.44 9.93 10 116138 595 46569319
Device related infection 10.44 9.93 23 116125 21018 46548896
Apnoea 10.43 9.93 41 116107 7298 46562616
Abnormal sleep-related event 10.42 9.93 11 116137 736 46569178
Panic disorder 10.42 9.93 21 116127 2540 46567374
Drug tolerance 10.36 9.93 24 116124 3194 46566720
Gait disturbance 10.33 9.93 451 115697 144812 46425102
Tubulointerstitial nephritis 10.27 9.93 13 116135 14775 46555139
Metastases to lung 10.26 9.93 7 116141 10689 46559225
Product dose omission issue 10.22 9.93 515 115633 168005 46401909
Coagulopathy 10.22 9.93 19 116129 18480 46551434
Oesophageal spasm 10.19 9.93 18 116130 1971 46567943
Hyperphagia 10.18 9.93 16 116132 1592 46568322
Feeling guilty 10.16 9.93 9 116139 484 46569430
Fear 10.14 9.93 72 116076 16100 46553814
Inadequate analgesia 10.14 9.93 22 116126 2802 46567112
Agraphia 10.09 9.93 4 116144 45 46569869
Purpura senile 10.03 9.93 10 116138 625 46569289

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 2208.04 11.46 1591 47816 97901 29805170
Depression 841.81 11.46 883 48524 89554 29813517
Toxicity to various agents 585.80 11.46 1046 48361 176137 29726934
Serotonin syndrome 449.37 11.46 310 49097 17581 29885490
Suicidal ideation 298.69 11.46 332 49075 35782 29867289
Overdose 266.06 11.46 489 48918 83848 29819223
Intentional overdose 259.91 11.46 331 49076 41150 29861921
Anxiety 246.46 11.46 491 48916 89380 29813691
Seizure 223.50 11.46 498 48909 97977 29805094
Poisoning 199.66 11.46 159 49248 11223 29891848
Drug abuse 180.46 11.46 410 48997 81662 29821409
Drug interaction 175.03 11.46 721 48686 198847 29704224
Generalised tonic-clonic seizure 174.16 11.46 187 49220 19364 29883707
Cardio-respiratory arrest 167.72 11.46 322 49085 56984 29846087
Electrocardiogram QRS complex prolonged 153.96 11.46 93 49314 4184 29898887
Status epilepticus 139.62 11.46 128 49279 10944 29892127
Febrile neutropenia 121.89 11.46 16 49391 106677 29796394
Anaemia 119.17 11.46 101 49306 207891 29695180
Tremor 117.90 11.46 331 49076 75032 29828039
Suicide attempt 117.01 11.46 214 49193 36483 29866588
Thrombocytopenia 113.71 11.46 42 49365 137002 29766069
Agitation 107.66 11.46 260 49147 53813 29849258
Hyperreflexia 105.47 11.46 63 49344 2776 29900295
Product substitution issue 103.77 11.46 104 49303 9931 29893140
Acute kidney injury 103.19 11.46 184 49223 273658 29629413
Respiratory arrest 88.71 11.46 167 49240 29091 29873980
Pyrexia 80.76 11.46 235 49172 294254 29608817
Sepsis 80.24 11.46 74 49333 146321 29756750
Insomnia 79.74 11.46 335 49072 93001 29810070
Postmortem blood drug level increased 78.48 11.46 22 49385 118 29902953
Neutropenia 74.02 11.46 62 49345 128478 29774593
Sexual dysfunction 72.98 11.46 68 49339 5933 29897138
Paranoia 71.26 11.46 86 49321 10102 29892969
Irritability 70.41 11.46 132 49275 22918 29880153
Therapeutic response unexpected 70.34 11.46 80 49327 8823 29894248
Depression suicidal 68.33 11.46 36 49371 1240 29901831
Psychotic disorder 67.96 11.46 125 49282 21390 29881681
Malignant neoplasm progression 67.31 11.46 18 49389 72269 29830802
General physical health deterioration 66.96 11.46 41 49366 99903 29803168
Pneumonia 64.66 11.46 308 49099 333998 29569073
Tearfulness 63.43 11.46 37 49370 1559 29901512
Platelet count decreased 61.32 11.46 51 49356 106078 29796993
Interstitial lung disease 59.94 11.46 13 49394 60184 29842887
Pancytopenia 59.65 11.46 33 49374 85019 29818052
Psychiatric decompensation 59.01 11.46 33 49374 1282 29901789
Septic shock 58.91 11.46 16 49391 63591 29839480
Erectile dysfunction 56.95 11.46 105 49302 17997 29885074
Suspected suicide 55.07 11.46 44 49363 3117 29899954
Electrocardiogram QT prolonged 54.60 11.46 156 49251 35679 29867392
Cardiac arrest 53.73 11.46 298 49109 92552 29810519
Multiple organ dysfunction syndrome 53.37 11.46 19 49388 63468 29839603
Anger 53.28 11.46 78 49329 11042 29892029
Product complaint 52.49 11.46 56 49351 5750 29897321
Vein of Galen aneurysmal malformation 51.89 11.46 11 49396 11 29903060
Renal impairment 51.72 11.46 38 49369 84146 29818925
Disturbance in attention 51.25 11.46 113 49294 22016 29881055
Major depression 49.72 11.46 46 49361 3976 29899095
Exposure via ingestion 49.06 11.46 38 49369 2573 29900498
Feeling abnormal 48.64 11.46 204 49203 56552 29846519
Drug withdrawal syndrome 47.98 11.46 103 49304 19706 29883365
Dyspnoea 46.35 11.46 341 49066 332954 29570117
Disease progression 45.36 11.46 39 49368 79835 29823236
Diarrhoea 44.95 11.46 345 49062 333758 29569313
Cardiac failure 43.52 11.46 44 49363 83374 29819697
Euphoric mood 43.50 11.46 44 49363 4246 29898825
Haemoglobin decreased 42.51 11.46 77 49330 114021 29789050
Clonus 42.09 11.46 34 49373 2447 29900624
Hyperkalaemia 41.58 11.46 29 49378 65981 29837090
Intentional product misuse 40.83 11.46 138 49269 34529 29868542
Myoclonus 40.35 11.46 76 49331 13236 29889835
C-reactive protein increased 40.13 11.46 11 49396 43462 29859609
Maternal drugs affecting foetus 40.03 11.46 42 49365 4231 29898840
Libido decreased 39.45 11.46 43 49364 4523 29898548
Tardive dyskinesia 39.20 11.46 45 49362 5012 29898059
Memory impairment 38.63 11.46 142 49265 37032 29866039
Autonomic nervous system imbalance 38.60 11.46 32 49375 2389 29900682
Renal failure 38.14 11.46 99 49308 128867 29774204
Loss of personal independence in daily activities 38.03 11.46 99 49308 21436 29881635
Depressive symptom 37.76 11.46 27 49380 1618 29901453
Electrocardiogram PR prolongation 36.87 11.46 20 49387 731 29902340
Neonatal toxicity 36.25 11.46 9 49398 27 29903044
Tinnitus 35.96 11.46 81 49326 16007 29887064
Product residue present 35.79 11.46 32 49375 2646 29900425
Dysphoria 35.52 11.46 29 49378 2119 29900952
Pleural effusion 35.39 11.46 42 49365 74024 29829047
Hallucination, visual 34.76 11.46 80 49327 16033 29887038
Panic attack 34.71 11.46 56 49351 8625 29894446
Dry mouth 34.33 11.46 99 49308 22751 29880320
Hyponatraemic coma 34.06 11.46 9 49398 37 29903034
Leukopenia 33.65 11.46 26 49381 56133 29846938
Pupil fixed 32.99 11.46 26 49381 1806 29901265
Mood swings 32.98 11.46 51 49356 7575 29895496
Lactic acidosis 32.61 11.46 6 49401 31207 29871864
Mania 32.52 11.46 56 49351 9098 29893973
Basilar artery occlusion 32.25 11.46 10 49397 80 29902991
Rheumatoid arthritis 31.87 11.46 14 49393 41183 29861888
Depressed mood 31.85 11.46 80 49327 16949 29886122
Hepatic function abnormal 31.29 11.46 15 49392 41930 29861141
Drug reaction with eosinophilia and systemic symptoms 30.81 11.46 5 49402 28483 29874588
Talipes 30.65 11.46 24 49383 1651 29901420
Melaena 30.32 11.46 8 49399 32429 29870642
Weight increased 28.85 11.46 217 49190 74696 29828375
Hallucination 28.70 11.46 158 49249 48901 29854170
Blood creatinine increased 28.67 11.46 68 49339 91307 29811764
Respiratory failure 28.42 11.46 79 49328 100563 29802508
Cytomegalovirus infection 28.37 11.46 3 49404 23671 29879400
Hypomania 28.27 11.46 26 49381 2230 29900841
Delirium 28.02 11.46 137 49270 40494 29862577
Infection 27.91 11.46 54 49353 78020 29825051
Cholestasis 27.85 11.46 4 49403 24946 29878125
Akathisia 27.69 11.46 41 49366 5863 29897208
Mucosal inflammation 27.61 11.46 8 49399 30486 29872585
Aggression 27.31 11.46 127 49280 36780 29866291
Bone marrow failure 26.63 11.46 8 49399 29777 29873294
Ascites 26.56 11.46 13 49394 35908 29867163
Hallucinations, mixed 26.15 11.46 26 49381 2457 29900614
Intentional self-injury 25.75 11.46 64 49343 13468 29889603
Encephalopathy neonatal 25.72 11.46 7 49400 33 29903038
Sedation 25.63 11.46 72 49335 16301 29886770
Erythema 25.62 11.46 56 49351 77395 29825676
Thinking abnormal 25.07 11.46 37 49370 5274 29897797
Mood altered 24.87 11.46 47 49360 8203 29894868
Gastrointestinal haemorrhage 24.69 11.46 64 49343 83382 29819689
Abnormal behaviour 24.24 11.46 95 49312 25528 29877543
Eosinophilia 23.71 11.46 4 49403 22156 29880915
White blood cell count decreased 23.62 11.46 66 49341 83881 29819190
Mental status changes 23.44 11.46 122 49285 36957 29866114
Cardiogenic shock 23.37 11.46 71 49336 16790 29886281
Withdrawal syndrome 23.33 11.46 55 49352 11195 29891876
Psychomotor skills impaired 23.24 11.46 22 49385 1957 29901114
Dehydration 23.07 11.46 115 49292 123424 29779647
Depersonalisation/derealisation disorder 23.04 11.46 13 49394 514 29902557
Product use in unapproved indication 22.98 11.46 55 49352 73638 29829433
Cerebral haemorrhage 22.69 11.46 13 49394 32874 29870197
Atrial septal defect 22.51 11.46 40 49367 6661 29896410
Hypokalaemia 22.37 11.46 30 49377 50162 29852909
Restlessness 22.36 11.46 85 49322 22514 29880557
Substance abuse 22.34 11.46 41 49366 6999 29896072
Incorrect route of product administration 22.05 11.46 54 49353 11261 29891810
Disseminated intravascular coagulation 21.63 11.46 5 49402 22166 29880905
Psychomotor retardation 21.60 11.46 23 49384 2356 29900715
Gun shot wound 21.56 11.46 17 49390 1181 29901890
Hallucination, auditory 21.55 11.46 49 49358 9740 29893331
Feeling jittery 21.41 11.46 29 49378 3819 29899252
Stomatitis 21.40 11.46 18 49389 37261 29865810
Orgasm abnormal 21.29 11.46 8 49399 120 29902951
Gamma-glutamyltransferase increased 21.13 11.46 11 49396 29339 29873732
Unresponsive to stimuli 21.10 11.46 93 49314 26326 29876745
Nightmare 20.79 11.46 55 49352 12021 29891050
Hallucination, tactile 20.78 11.46 10 49397 283 29902788
Malaise 20.70 11.46 176 49231 166786 29736285
Dyskinesia 20.69 11.46 81 49326 21753 29881318
Mydriasis 19.78 11.46 36 49371 6107 29896964
Social avoidant behaviour 19.74 11.46 24 49383 2839 29900232
Depressed level of consciousness 19.67 11.46 119 49288 38103 29864968
Jaundice 19.50 11.46 15 49392 32471 29870600
Pre-existing condition improved 19.34 11.46 20 49387 1981 29901090
Drug withdrawal syndrome neonatal 19.32 11.46 25 49382 3150 29899921
Neutrophil count decreased 19.30 11.46 25 49382 42429 29860642
Delusion 19.04 11.46 53 49354 11936 29891135
Amnesia 18.96 11.46 85 49322 24236 29878835
Liver disorder 18.78 11.46 13 49394 29709 29873362
Haematuria 18.78 11.46 28 49379 44806 29858265
Tachycardia 18.73 11.46 195 49212 73544 29829527
Off label use 18.71 11.46 294 49113 248996 29654075
Sleep disorder 18.67 11.46 85 49322 24394 29878677
Transposition of the great vessels 18.49 11.46 11 49396 481 29902590
Road traffic accident 18.39 11.46 66 49341 17005 29886066
Ideas of reference 18.35 11.46 6 49401 58 29903013
Infusion related reaction 18.32 11.46 24 49383 40540 29862531
Atrial fibrillation 18.31 11.46 104 49303 108020 29795051
Accidental poisoning 18.24 11.46 11 49396 493 29902578
Crying 18.22 11.46 33 49374 5576 29897495
Persecutory delusion 18.22 11.46 20 49387 2120 29900951
Bradyphrenia 17.87 11.46 27 49380 3930 29899141
Balance disorder 17.76 11.46 112 49295 36381 29866690
Disorientation 17.58 11.46 100 49307 31318 29871753
Marital problem 17.26 11.46 6 49401 71 29903000
Loss of libido 17.24 11.46 19 49388 2023 29901048
Vision blurred 17.15 11.46 123 49284 41693 29861378
Blood testosterone decreased 17.08 11.46 28 49379 4368 29898703
Incoherent 17.06 11.46 27 49380 4091 29898980
Drug dependence 17.03 11.46 75 49332 21220 29881851
Apathy 16.96 11.46 34 49373 6198 29896873
Drug resistance 16.95 11.46 6 49401 20127 29882944
Tongue biting 16.94 11.46 12 49395 708 29902363
Foetal exposure during pregnancy 16.63 11.46 111 49296 36760 29866311
Plasma cell myeloma 16.59 11.46 40 49367 53422 29849649
Alcoholism 16.43 11.46 24 49383 3390 29899681
Brugada syndrome 16.35 11.46 11 49396 597 29902474
Treatment failure 16.20 11.46 20 49387 34659 29868412
Agranulocytosis 16.13 11.46 8 49399 21934 29881137
Blood cholesterol increased 16.11 11.46 63 49344 16907 29886164
Pelvic abscess 16.05 11.46 13 49394 939 29902132
Dissociation 16.02 11.46 14 49393 1123 29901948
Abdominal pain 15.92 11.46 145 49262 135509 29767562
Hyperhidrosis 15.91 11.46 175 49232 66915 29836156
Restless legs syndrome 15.80 11.46 35 49372 6837 29896234
Acute myeloid leukaemia 15.80 11.46 5 49402 18001 29885070
Blood triglycerides increased 15.79 11.46 55 49352 13962 29889109
Oedema peripheral 15.74 11.46 106 49301 105726 29797345
Impaired work ability 15.61 11.46 31 49376 5612 29897459
Poor feeding infant 15.58 11.46 9 49398 372 29902699
Injection site reaction 15.56 11.46 46 49361 10714 29892357
Hunger 15.56 11.46 15 49392 1365 29901706
Emotional distress 15.35 11.46 59 49348 15706 29887365
Hypotonia neonatal 15.17 11.46 13 49394 1016 29902055
Myelodysplastic syndrome 15.13 11.46 6 49401 18772 29884299
Dependence 15.11 11.46 14 49393 1212 29901859
Accidental overdose 15.10 11.46 65 49342 18210 29884861
Clonic convulsion 15.06 11.46 10 49397 531 29902540
Hepatocellular injury 14.99 11.46 12 49395 25459 29877612
Product quality issue 14.92 11.46 66 49341 18708 29884363
Lung disorder 14.86 11.46 18 49389 31451 29871620
Hypoplastic right heart syndrome 14.85 11.46 4 49403 18 29903053
Rhinitis perennial 14.81 11.46 6 49401 111 29902960
Obesity 14.76 11.46 39 49368 8516 29894555
Dysphemia 14.67 11.46 15 49392 1466 29901605
Injection site mass 14.66 11.46 28 49379 4925 29898146
Hostility 14.58 11.46 12 49395 887 29902184
Cough 14.43 11.46 135 49272 125507 29777564
Impulsive behaviour 14.42 11.46 17 49390 1948 29901123
Drug screen positive 14.41 11.46 26 49381 4381 29898690
Cognitive disorder 14.32 11.46 77 49330 23613 29879458
Priapism 14.27 11.46 27 49380 4716 29898355
Obsessive-compulsive disorder 14.27 11.46 25 49382 4116 29898955
Emotional disorder 14.11 11.46 28 49379 5066 29898005
Ventricular hypoplasia 14.03 11.46 5 49402 64 29903007
Decreased appetite 14.02 11.46 169 49238 149741 29753330
Symptom masked 13.97 11.46 9 49398 454 29902617
Nervousness 13.93 11.46 47 49360 11741 29891330
Epistaxis 13.92 11.46 43 49364 52938 29850133
Bruxism 13.89 11.46 14 49393 1345 29901726
Exposure during pregnancy 13.79 11.46 40 49367 9221 29893850
Bicuspid aortic valve 13.62 11.46 7 49400 229 29902842
Urinary tract infection 13.49 11.46 69 49338 73590 29829481
Sinus tachycardia 13.48 11.46 56 49351 15448 29887623
Extra dose administered 13.47 11.46 20 49387 2866 29900205
Upper gastrointestinal haemorrhage 13.44 11.46 10 49397 22018 29881053
Death 13.37 11.46 469 48938 356814 29546257
Blood pressure decreased 13.24 11.46 37 49370 47038 29856033
Loss of employment 13.22 11.46 9 49398 498 29902573
Migraine 13.21 11.46 49 49358 12825 29890246
Cerebral disorder 13.16 11.46 18 49389 2392 29900679
Cardiotoxicity 13.12 11.46 25 49382 4389 29898682
Drug tolerance 13.12 11.46 17 49390 2145 29900926
International normalised ratio increased 13.08 11.46 38 49369 47701 29855370
Toxic optic neuropathy 12.97 11.46 10 49397 672 29902399
Binge drinking 12.94 11.46 3 49404 6 29903065
Pulmonary fibrosis 12.93 11.46 5 49402 15885 29887186
Pulmonary valve disease 12.73 11.46 5 49402 85 29902986
Postictal state 12.67 11.46 10 49397 696 29902375
Pneumonitis 12.65 11.46 16 49391 27438 29875633
Testicular pain 12.64 11.46 19 49388 2753 29900318
Treatment noncompliance 12.60 11.46 78 49329 25175 29877896
Past-pointing 12.59 11.46 4 49403 35 29903036
Compartment syndrome 12.50 11.46 18 49389 2509 29900562
Persistent depressive disorder 12.49 11.46 7 49400 273 29902798
Respiratory distress 12.49 11.46 22 49385 32950 29870121
Life expectancy shortened 12.49 11.46 4 49403 36 29903035
Congenital aortic stenosis 12.42 11.46 5 49402 91 29902980
Affective disorder 12.35 11.46 20 49387 3088 29899983
Neuropathy peripheral 12.35 11.46 67 49340 70408 29832663
Hepatic encephalopathy 12.35 11.46 4 49403 14188 29888883
Alcohol use 12.08 11.46 22 49385 3733 29899338
Anaphylactic shock 12.07 11.46 4 49403 13989 29889082
Suicidal behaviour 12.07 11.46 13 49394 1349 29901722
Genital discomfort 12.02 11.46 4 49403 41 29903030
Bipolar disorder 11.99 11.46 22 49385 3754 29899317
Osteonecrosis of jaw 11.96 11.46 8 49399 18610 29884461
Gastric ulcer 11.91 11.46 5 49402 15116 29887955
Post-traumatic stress disorder 11.90 11.46 14 49393 1601 29901470
Tongue spasm 11.77 11.46 4 49403 44 29903027
Hepatic failure 11.76 11.46 24 49383 34019 29869052
Feelings of worthlessness 11.60 11.46 6 49401 199 29902872
Ejaculation failure 11.60 11.46 10 49397 788 29902283
Inadequate analgesia 11.56 11.46 18 49389 2690 29900381
Dysarthria 11.54 11.46 88 49319 30402 29872669
Ejaculation disorder 11.52 11.46 11 49396 989 29902082
Cerebral infarction 11.51 11.46 16 49391 26357 29876714
Deep vein thrombosis 11.46 11.46 56 49351 60445 29842626

Pharmacologic Action:

SourceCodeDescription
ATC A08AA62 ALIMENTARY TRACT AND METABOLISM
ANTIOBESITY PREPARATIONS, EXCL. DIET PRODUCTS
ANTIOBESITY PREPARATIONS, EXCL. DIET PRODUCTS
Centrally acting antiobesity products
ATC N06AX12 NERVOUS SYSTEM
PSYCHOANALEPTICS
ANTIDEPRESSANTS
Other antidepressants
FDA MoA N0000000102 Norepinephrine Uptake Inhibitors
FDA MoA N0000000114 Dopamine Uptake Inhibitors
FDA PE N0000009282 Increased Dopamine Activity
FDA PE N0000009456 Increased Norepinephrine Activity
CHEBI has role CHEBI:35469 thymoanaleptics
CHEBI has role CHEBI:35703 xenobiotic
CHEBI has role CHEBI:78298 environmental contaminants
MeSH PA D000928 Antidepressive Agents
MeSH PA D018687 Antidepressive Agents, Second-Generation
MeSH PA D002491 Central Nervous System Agents
MeSH PA D065690 Cytochrome P-450 CYP2D6 Inhibitors
MeSH PA D065607 Cytochrome P-450 Enzyme Inhibitors
MeSH PA D015259 Dopamine Agents
MeSH PA D018765 Dopamine Uptake Inhibitors
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D065606 Metabolic Side Effects of Drugs and Substances
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D014179 Neurotransmitter Uptake Inhibitors
MeSH PA D011619 Psychotropic Drugs
MeSH PA D000077444 Smoking Cessation Agents
FDA EPC N0000180855 Aminoketone

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Depressive disorder indication 35489007
Nicotine dependence indication 56294008 DOID:0050742
Seasonal affective disorder indication 247803002
Major depressive disorder indication 370143000
Smoking cessation assistance indication 384742004
Obesity indication 414916001 DOID:9970
Bipolar affective disorder, current episode depression off-label use 191627008 DOID:3312
Attention deficit hyperactivity disorder off-label use 406506008
Suicidal thoughts contraindication 6471006
Alcoholism contraindication 7200002
Mood swings contraindication 18963009
Lowered convulsive threshold contraindication 19260006
Cirrhosis of liver contraindication 19943007 DOID:5082
Myocardial infarction contraindication 22298006 DOID:5844
Feeling agitated contraindication 24199005
Hypertensive disorder contraindication 38341003 DOID:10763
Anorexia nervosa contraindication 56882008 DOID:8689
Hepatic failure contraindication 59927004
Psychotic disorder contraindication 69322001
Opioid dependence contraindication 75544000 DOID:2559
Bulimia nervosa contraindication 78004001
Hostile behavior contraindication 79351003
Injury of head contraindication 82271004
Weight loss contraindication 89362005
Kidney disease contraindication 90708001 DOID:557
Secondary malignant neoplasm of cerebrum contraindication 94248000
Neoplasm of central nervous system contraindication 126951006 DOID:3620
Seizure disorder contraindication 128613002
Bipolar affective disorder, current episode manic contraindication 191618007
Disease of liver contraindication 235856003 DOID:409
Diabetic - poor control contraindication 268519009
Alcohol withdrawal-induced convulsion contraindication 308742005
Panic disorder contraindication 371631005 DOID:594
Sedative Drug Dependence contraindication
Seizure due to Abrupt Benzodiazepine Withdrawal contraindication
Stimulant Drug Dependence contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.87 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Sodium-dependent noradrenaline transporter Transporter INHIBITOR Ki 5.16 CHEMBL CHEMBL
Sodium-dependent dopamine transporter Transporter INHIBITOR Kd 6.28 WOMBAT-PK CHEMBL
Neuronal acetylcholine receptor subunit alpha-7 Ion channel IC50 4.30 CHEMBL
Neuronal acetylcholine receptor; alpha3/beta2 Ion channel IC50 6 CHEMBL
Neuronal acetylcholine receptor; alpha3/beta4 Ion channel IC50 5.74 CHEMBL
Sodium-dependent serotonin transporter Transporter Kd 5.04 WOMBAT-PK
Cytochrome P450 2D6 Enzyme WOMBAT-PK
Alpha-1A adrenergic receptor GPCR Ki 4.80 PDSP
Cytochrome P450 2C19 Enzyme IC50 5.70 DRUG MATRIX
Membrane-associated progesterone receptor component 1 Membrane receptor Ki 5.85 DRUG MATRIX
Sodium-dependent dopamine transporter Transporter IC50 5.91 CHEMBL

External reference:

IDSource
4019645 VUID
N0000147738 NUI
D00817 KEGG_DRUG
905818-69-1 SECONDARY_CAS_RN
4019483 VANDF
4019645 VANDF
4029878 VANDF
C0085208 UMLSCUI
CHEBI:3219 CHEBI
CHEMBL1201735 ChEMBL_ID
CHEMBL894 ChEMBL_ID
CHEMBL1698 ChEMBL_ID
DB01156 DRUGBANK_ID
D016642 MESH_DESCRIPTOR_UI
444 PUBCHEM_CID
3562 INN_ID
7135 IUPHAR_LIGAND_ID
01ZG3TPX31 UNII
203204 RXNORM
162122 MMSL
26259 MMSL
31548 MMSL
4307 MMSL
4319 MMSL
d00181 MMSL
001512 NDDF
004611 NDDF
012996 NDDF
387564004 SNOMEDCT_US
395733003 SNOMEDCT_US
431408005 SNOMEDCT_US
96199001 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Bupropion Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0115-5445 TABLET, FILM COATED, EXTENDED RELEASE 200 mg ORAL ANDA 30 sections
Bupropion Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0115-6811 TABLET, FILM COATED, EXTENDED RELEASE 150 mg ORAL ANDA 30 sections
WELLBUTRINSR HUMAN PRESCRIPTION DRUG LABEL 1 0173-0135 TABLET, FILM COATED 150 mg ORAL NDA 29 sections
WELLBUTRINSR HUMAN PRESCRIPTION DRUG LABEL 1 0173-0722 TABLET, FILM COATED 200 mg ORAL NDA 29 sections
WELLBUTRINSR HUMAN PRESCRIPTION DRUG LABEL 1 0173-0947 TABLET, FILM COATED 100 mg ORAL NDA 29 sections
Bupropion Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0185-0410 TABLET, EXTENDED RELEASE 100 mg ORAL ANDA 29 sections
Bupropion Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0185-0415 TABLET, EXTENDED RELEASE 150 mg ORAL ANDA 29 sections
Bupropion Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0185-1111 TABLET, EXTENDED RELEASE 200 mg ORAL ANDA 29 sections
WELLBUTRINXL HUMAN PRESCRIPTION DRUG LABEL 1 0187-0730 TABLET, EXTENDED RELEASE 150 mg ORAL NDA 28 sections
WELLBUTRINXL HUMAN PRESCRIPTION DRUG LABEL 1 0187-0731 TABLET, EXTENDED RELEASE 300 mg ORAL NDA 28 sections
Aplenzin HUMAN PRESCRIPTION DRUG LABEL 1 0187-5810 TABLET, EXTENDED RELEASE 174 mg ORAL NDA 29 sections
Aplenzin HUMAN PRESCRIPTION DRUG LABEL 1 0187-5811 TABLET, EXTENDED RELEASE 348 mg ORAL NDA 29 sections
Aplenzin HUMAN PRESCRIPTION DRUG LABEL 1 0187-5812 TABLET, EXTENDED RELEASE 522 mg ORAL NDA 29 sections
Bupropion Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0440-7200 TABLET, FILM COATED, EXTENDED RELEASE 150 mg ORAL ANDA 28 sections
Bupropion HydrochlorideXL HUMAN PRESCRIPTION DRUG LABEL 1 0591-3331 TABLET, FILM COATED, EXTENDED RELEASE 150 mg ORAL ANDA 29 sections
Bupropion HydrochlorideSR HUMAN PRESCRIPTION DRUG LABEL 1 0591-3540 TABLET, FILM COATED, EXTENDED RELEASE 100 mg ORAL ANDA 29 sections
Bupropion HydrochlorideSR HUMAN PRESCRIPTION DRUG LABEL 1 0591-3541 TABLET, FILM COATED, EXTENDED RELEASE 150 mg ORAL ANDA 29 sections
Bupropion HydrochlorideSR HUMAN PRESCRIPTION DRUG LABEL 1 0591-3542 TABLET, FILM COATED, EXTENDED RELEASE 200 mg ORAL ANDA 29 sections
Bupropion HydrochlorideSR HUMAN PRESCRIPTION DRUG LABEL 1 0591-3543 TABLET, FILM COATED, EXTENDED RELEASE 150 mg ORAL ANDA 29 sections
Bupropion Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0615-7631 TABLET, FILM COATED 75 mg ORAL ANDA 27 sections
Bupropion Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0615-7632 TABLET, FILM COATED 100 mg ORAL ANDA 27 sections
Bupropion Hydrochloride(XL) HUMAN PRESCRIPTION DRUG LABEL 1 0615-8179 TABLET, EXTENDED RELEASE 300 mg ORAL ANDA 30 sections
Bupropion Hydrochloride(XL) HUMAN PRESCRIPTION DRUG LABEL 1 0615-8241 TABLET, EXTENDED RELEASE 150 mg ORAL ANDA 30 sections
bupropion Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0615-8261 TABLET 75 mg ORAL ANDA 25 sections
bupropion HUMAN PRESCRIPTION DRUG LABEL 1 0615-8262 TABLET, EXTENDED RELEASE 150 mg ORAL ANDA 31 sections
bupropion Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0615-8296 TABLET 100 mg ORAL ANDA 29 sections
Bupropion hydrochloride (XL) HUMAN PRESCRIPTION DRUG LABEL 1 0781-5528 TABLET, EXTENDED RELEASE 150 mg ORAL ANDA 21 sections
Bupropion hydrochloride (XL) HUMAN PRESCRIPTION DRUG LABEL 1 0781-5529 TABLET, EXTENDED RELEASE 300 mg ORAL ANDA 21 sections
Bupropion Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0904-6573 TABLET, FILM COATED, EXTENDED RELEASE 300 mg ORAL ANDA 30 sections
Bupropion Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0904-6585 TABLET, EXTENDED RELEASE 150 mg ORAL ANDA 29 sections