gepirone Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
anxiolytics, buspirone derivatives 4562 83928-76-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • gepirone ER
  • gepirone
  • gepirone monohydrochloride
  • gepirone hydrochloride
  • gepirone HCl
  • Molecular weight: 359.47
  • Formula: C19H29N5O2
  • CLOGP: 1.79
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 0
  • TPSA: 69.64
  • ALOGS: -2.52
  • ROTB: 6

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC N06AX19 NERVOUS SYSTEM
PSYCHOANALEPTICS
ANTIDEPRESSANTS
Other antidepressants
MeSH PA D014151 Anti-Anxiety Agents
MeSH PA D000928 Antidepressive Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D011619 Psychotropic Drugs
MeSH PA D018490 Serotonin Agents
MeSH PA D017366 Serotonin Receptor Agonists
MeSH PA D014149 Tranquilizing Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Major depressive disorder indication 370143000

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.51 Basic
pKa2 2.23 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
5-hydroxytryptamine receptor 1A GPCR AGONIST Ki 7.89 CHEMBL
D(2) dopamine receptor GPCR Ki 7.24 CHEMBL
Adrenergic receptor alpha-1 GPCR Ki 5.62 CHEMBL
Serotonin 1 (5-HT1) receptor GPCR IC50 6.17 CHEMBL
5-hydroxytryptamine receptor 1A GPCR Ki 7.50 CHEMBL

External reference:

IDSource
80C9L8EP6V UNII
83928-66-9 SECONDARY_CAS_RN
CHEMBL284092 ChEMBL_ID
5676 INN_ID
C039979 MESH_SUPPLEMENTAL_RECORD_UI
DB12184 DRUGBANK_ID
CHEBI:135990 CHEBI
CHEMBL1204187 ChEMBL_ID
55191 PUBCHEM_CID

Pharmaceutical products:

None