DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
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Structure 🔎
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L1000
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DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
Search
Structure 🔎
Similarity 🔎
Smart API
Redial
About
Download
L1000
FAQ
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All
FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
gepirone 🐶
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
anxiolytics, buspirone derivatives
4562
83928-76-1
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
gepirone ER
gepirone
gepirone monohydrochloride
gepirone hydrochloride
gepirone HCl
Molecular weight: 359.47
Formula: C19H29N5O2
CLOGP: 1.84
LIPINSKI: 0
HAC: 7
HDO: 0
TPSA: 69.64
ALOGS: -2.52
ROTB: 6
Drug dosage:
None
ADMET properties:
None
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
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Source
Code
Description
ATC
N06AX19
NERVOUS SYSTEM
PSYCHOANALEPTICS
ANTIDEPRESSANTS
Other antidepressants
MeSH PA
D014151
Anti-Anxiety Agents
MeSH PA
D000928
Antidepressive Agents
MeSH PA
D002491
Central Nervous System Agents
MeSH PA
D002492
Central Nervous System Depressants
MeSH PA
D018377
Neurotransmitter Agents
MeSH PA
D011619
Psychotropic Drugs
MeSH PA
D018490
Serotonin Agents
MeSH PA
D017366
Serotonin Receptor Agonists
MeSH PA
D014149
Tranquilizing Agents
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Drug Use
| Suggest Off label Use Form|
|View source of the data|
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Disease
Relation
SNOMED_ID
DOID
Major depressive disorder
indication
370143000
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🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
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Dissociation level
Dissociation constant
Type (acidic/basic)
pKa1
7.51
Basic
pKa2
2.23
Basic
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Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
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Target
Class
Pharos
UniProt
Action
Type
Activity value
(-log[M])
Mechanism
action
Bioact source
MoA source
D(2) dopamine receptor
GPCR
P14416
DRD2_HUMAN
Ki
7.24
CHEMBL
5-hydroxytryptamine receptor 1A
GPCR
P08908
5HT1A_HUMAN
AGONIST
Ki
7.89
CHEMBL
5-hydroxytryptamine receptor 2A
GPCR
P28223
5HT2A_HUMAN
Ki
5.44
CHEMBL
5-hydroxytryptamine receptor 1A
GPCR
5HT1A_RAT
Ki
7.50
CHEMBL
Serotonin 1 (5-HT1) receptor
GPCR
5HT1A_RAT
5HT1B_RAT
5HT1D_RAT
5HT1F_RAT
IC50
6.17
CHEMBL
Adrenergic receptor alpha-1
GPCR
ADA1B_RAT
ADA1D_RAT
ADA1A_RAT
Ki
5.62
CHEMBL
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External reference:
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ID
Source
55191
PUBCHEM_CID
5676
INN_ID
83928-66-9
SECONDARY_CAS_RN
C0066624
UMLSCUI
C039979
MESH_SUPPLEMENTAL_RECORD_UI
CHEBI:135990
CHEBI
CHEMBL1204187
ChEMBL_ID
CHEMBL284092
ChEMBL_ID
DB12184
DRUGBANK_ID
JW5Y7B8Z18
UNII
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Pharmaceutical products:
None
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gepirone