desvenlafaxine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4380	93413-62-8

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: desvenlafaxine desvenlafaxine succinate pristiq DVS-233 desvenlafaxine fumarate	The exact mechanism of the antidepressant action of desvenlafaxine is unknown, but is thought to be related to the potentiation of serotonin and norepinephrine in the central nervous system, through inhibition of their reuptake. Non-clinical studies have shown that desvenlafaxine is a potent and selective serotonin and norepinephrine reuptake inhibitor (SNRI). Molecular weight: 263.38 Formula: C16H25NO2 CLOGP: 2.68 LIPINSKI: 0 HAC: 3 HDO: 2 TPSA: 43.70 ALOGS: -2.27 ROTB: 4 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

desvenlafaxine
desvenlafaxine succinate
pristiq
DVS-233
desvenlafaxine fumarate

The exact mechanism of the antidepressant action of desvenlafaxine is unknown, but is thought to be related to the potentiation of serotonin and norepinephrine in the central nervous system, through inhibition of their reuptake. Non-clinical studies have shown that desvenlafaxine is a potent and selective serotonin and norepinephrine reuptake inhibitor (SNRI).

Molecular weight: 263.38
Formula: C16H25NO2
CLOGP: 2.68
LIPINSKI: 0
HAC: 3
HDO: 2
TPSA: 43.70
ALOGS: -2.27
ROTB: 4

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
50	mg	O

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	3	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	572 mg/mL	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	45 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	5.42 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution)	3.50 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	4.90 mL/min/kg	Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)	0.70 %	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	8.40 hours	Lombardo F, Berellini G, Obach RS

Approvals:

Date	Agency	Company	Orphan
Feb. 29, 2008	FDA	WYETH PHARMS INC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Product residue present	772.21	14.53	199	24197	3780	63460846
Drug withdrawal syndrome	652.65	14.53	280	24116	26914	63437712
Suicidal ideation	375.23	14.53	256	24140	62165	63402461
Withdrawal syndrome	306.81	14.53	151	24245	19846	63444780
Feeling abnormal	292.16	14.53	321	24075	148071	63316555
Crying	281.90	14.53	150	24246	23193	63441433
Anxiety	246.43	14.53	357	24039	217184	63247442
Irritability	216.84	14.53	141	24255	31553	63433073
Insomnia	212	14.53	331	24065	214921	63249705
Dizziness	157.79	14.53	440	23956	429485	63035141
Anger	147.39	14.53	79	24317	12377	63452249
Nausea	136.47	14.53	667	23729	853804	62610822
Hyperhidrosis	116.03	14.53	173	24223	107663	63356963
Headache	107.00	14.53	503	23893	632738	62831888
Panic attack	102.84	14.53	78	24318	22253	63442373
Tremor	101.37	14.53	182	24214	132057	63332569
Nervousness	100.07	14.53	88	24308	30891	63433735
Depression	98.85	14.53	227	24169	196265	63268361
Agitation	98.30	14.53	118	24278	59639	63404987
Emotional disorder	90.18	14.53	59	24337	13320	63451306
Intentional product misuse	86.90	14.53	112	24284	60805	63403821
Condition aggravated	85.72	14.53	343	24053	401874	63062752
Abnormal dreams	84.94	14.53	52	24344	10464	63454162
Completed suicide	75.09	14.53	170	24226	145503	63319123
Feeling jittery	73.43	14.53	52	24344	13351	63451275
Contraindicated product administered	70.78	14.53	3	24393	217645	63246981
Suicide attempt	68.74	14.53	100	24296	60818	63403808
Thinking abnormal	67.04	14.53	45	24351	10598	63454028
Nightmare	64.95	14.53	56	24340	19138	63445488
Persistent genital arousal disorder	58.86	14.53	15	24381	271	63464355
Synovitis	53.59	14.53	5	24391	186913	63277713
Depressed mood	52.82	14.53	71	24325	40120	63424506
Overdose	52.41	14.53	128	24268	114950	63349676
Serotonin syndrome	51.05	14.53	59	24337	28623	63436003
Systemic lupus erythematosus	49.55	14.53	10	24386	208908	63255718
Disturbance in attention	49.48	14.53	67	24329	38122	63426504
Product substitution issue	48.78	14.53	44	24352	15952	63448674
Seizure	48.60	14.53	136	24260	132498	63332128
Pyrexia	47.55	14.53	67	24329	470411	62994215
Middle insomnia	47.12	14.53	39	24357	12604	63452022
Impaired driving ability	46.15	14.53	26	24370	4485	63460141
Drug ineffective	45.03	14.53	604	23792	1044161	62420465
Joint swelling	43.76	14.53	37	24359	327629	63136997
Pre-existing condition improved	42.89	14.53	31	24365	8213	63456413
Drug screen positive	42.87	14.53	23	24373	3606	63461020
Paraesthesia	42.65	14.53	145	24251	156821	63307805
Maternal exposure during pregnancy	42.02	14.53	16	24380	220046	63244580
Mania	41.67	14.53	36	24360	12331	63452295
Vision blurred	41.58	14.53	102	24294	91822	63372804
Migraine	40.87	14.53	109	24287	103237	63361389
Mydriasis	40.68	14.53	35	24361	11921	63452705
Acute kidney injury	40.00	14.53	26	24370	263389	63201237
Anorgasmia	39.59	14.53	13	24383	590	63464036
Tinnitus	39.47	14.53	58	24338	35570	63429056
Pericarditis	39.13	14.53	3	24393	131576	63333050
Blood pressure increased	39.12	14.53	144	24252	161918	63302708
Stomatitis	39.00	14.53	4	24392	138721	63325905
Dissociation	38.75	14.53	20	24376	2899	63461727
Somnolence	38.40	14.53	153	24243	178532	63286094
Anaemia	38.12	14.53	34	24362	293396	63171230
Bruxism	37.93	14.53	21	24375	3504	63461122
Coma scale abnormal	37.87	14.53	24	24372	5129	63459497
General physical health deterioration	37.86	14.53	15	24381	201387	63263239
Therapeutic response unexpected	37.50	14.53	41	24355	18718	63445908
Treatment failure	37.13	14.53	15	24381	199028	63265598
Energy increased	36.98	14.53	19	24377	2728	63461898
Aggression	34.74	14.53	44	24352	23454	63441172
Drug screen false positive	34.72	14.53	13	24383	871	63463755
Neutropenia	34.63	14.53	12	24384	174993	63289633
Mood altered	34.42	14.53	35	24361	14708	63449918
Arthropathy	33.22	14.53	25	24371	234767	63229859
Restlessness	32.70	14.53	48	24348	29405	63435221
Rheumatoid arthritis	32.26	14.53	30	24366	253789	63210837
Yawning	32.20	14.53	13	24383	1067	63463559
Lower respiratory tract infection	32.06	14.53	6	24390	132301	63332325
Paranoia	31.50	14.53	30	24366	11649	63452977
Infusion related reaction	31.22	14.53	29	24367	245492	63219134
Weight increased	30.65	14.53	188	24208	260604	63204022
Thrombocytopenia	30.54	14.53	10	24386	151147	63313479
Mood swings	29.92	14.53	36	24360	18212	63446414
Death	29.81	14.53	62	24334	374319	63090307
Peripheral swelling	29.78	14.53	35	24361	265907	63198719
Palpitations	29.59	14.53	103	24293	112667	63351959
Tachyphrenia	29.18	14.53	13	24383	1361	63463265
Mental disorder	28.43	14.53	42	24354	25877	63438749
Abnormal behaviour	28.37	14.53	38	24358	21388	63443238
Drug hypersensitivity	28.15	14.53	210	24186	310477	63154149
Euphoric mood	26.86	14.53	19	24377	4868	63459758
Stress	26.70	14.53	71	24325	67096	63397530
Wound	26.32	14.53	15	24381	163248	63301378
Libido decreased	26.26	14.53	15	24381	2657	63461969
Swelling	26.03	14.53	41	24355	275337	63189289
Nonspecific reaction	25.61	14.53	14	24382	2278	63462348
Amnesia	25.46	14.53	62	24334	55523	63409103
Glossodynia	25.36	14.53	19	24377	178857	63285769
Hostility	25.35	14.53	13	24383	1859	63462767
Hypersensitivity vasculitis	24.97	14.53	17	24379	4095	63460531
Infection	24.76	14.53	31	24365	229142	63235484
Panic reaction	24.74	14.53	17	24379	4157	63460469
Sympathomimetic effect	24.59	14.53	6	24390	90	63464536
Bipolar disorder	24.47	14.53	22	24374	7938	63456688
Unevaluable event	24.27	14.53	58	24338	51328	63413298
Tardive dyskinesia	23.23	14.53	22	24374	8480	63456146
Loss of libido	23.13	14.53	11	24385	1338	63463288
Wrong technique in product usage process	22.88	14.53	64	24332	62276	63402350
Apathy	22.60	14.53	22	24374	8772	63455854
Impaired healing	22.13	14.53	6	24390	102536	63362090
Febrile neutropenia	21.96	14.53	9	24387	118440	63346186
Hallucination	21.84	14.53	58	24338	54759	63409867
Post-traumatic stress disorder	21.25	14.53	17	24379	5234	63459392
Abdominal discomfort	20.90	14.53	59	24337	320826	63143800
Obsessive-compulsive disorder	20.51	14.53	15	24381	4045	63460581
Negative thoughts	20.42	14.53	9	24387	918	63463708
Tearfulness	20.26	14.53	15	24381	4124	63460502
Sepsis	19.55	14.53	18	24378	153105	63311521
Hepatic enzyme increased	19.23	14.53	30	24366	202298	63262328
Hallucination, auditory	18.93	14.53	24	24372	12800	63451826
Brain injury	18.82	14.53	18	24378	7025	63457601
Suicidal behaviour	18.67	14.53	12	24384	2627	63461999
Drug intolerance	18.48	14.53	59	24337	308602	63156024
Malaise	18.36	14.53	242	24154	415712	63048914
Alopecia	17.87	14.53	68	24328	337468	63127158
Pneumonia	17.73	14.53	103	24293	456664	63007962
Muscle twitching	17.57	14.53	29	24367	19639	63444987
Memory impairment	17.56	14.53	83	24313	104175	63360451
Restless legs syndrome	17.47	14.53	28	24368	18503	63446123
Product prescribing error	17.38	14.53	34	24362	26255	63438371
Intestinal pseudo-obstruction	17.38	14.53	8	24388	904	63463722
Arthralgia	17.37	14.53	138	24258	569572	62895054
Hypertensive emergency	16.99	14.53	10	24386	1872	63462754
Drug dependence	16.59	14.53	32	24364	24451	63440175
Decreased interest	16.39	14.53	12	24384	3242	63461384
Therapeutic response changed	16.34	14.53	8	24388	1037	63463589
Blood triglycerides increased	16.31	14.53	22	24374	12466	63452160
Impatience	16.27	14.53	6	24390	385	63464241
Wrong strength	16.27	14.53	4	24392	62	63464564
Malabsorption	16.09	14.53	13	24383	4059	63460567
Wernicke-Korsakoff syndrome	15.98	14.53	4	24392	67	63464559
Renal impairment	15.91	14.53	7	24389	88348	63376278
Feeling drunk	15.90	14.53	13	24383	4129	63460497
Galactorrhoea	15.86	14.53	13	24383	4142	63460484
Change in seizure presentation	15.82	14.53	6	24390	417	63464209
Discomfort	15.72	14.53	25	24371	167349	63297277
Pain	15.66	14.53	196	24200	740432	62724194
Malignant neoplasm progression	15.61	14.53	6	24390	82115	63382511
Dyspnoea	15.52	14.53	171	24225	661142	62803484
Ill-defined disorder	15.50	14.53	6	24390	81749	63382877
Coma	15.41	14.53	3	24393	64361	63400265
Aerophagia	15.40	14.53	3	24393	14	63464612
Insulinoma	15.17	14.53	4	24392	83	63464543
Major depression	15.12	14.53	17	24379	8001	63456625
Affect lability	15.10	14.53	20	24376	11131	63453495
Vertigo	15.09	14.53	54	24342	59833	63404793
Disease progression	15.01	14.53	15	24381	122743	63341883
Sleep-related eating disorder	14.77	14.53	7	24389	844	63463782
Impaired work ability	14.59	14.53	25	24371	17450	63447176

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Product residue present	228.17	22.39	61	6812	2685	34947373
Serotonin syndrome	184.02	22.39	86	6787	19847	34930211
Drug withdrawal syndrome	166.01	22.39	80	6793	19754	34930304
Suicidal ideation	124.88	22.39	85	6788	40303	34909755
Anxiety	100.18	22.39	110	6763	99318	34850740
Suicide attempt	73.22	22.39	61	6812	39055	34911003
Hyperhidrosis	73.15	22.39	82	6791	75610	34874448
Overdose	70.39	22.39	88	6785	90971	34859087
Sexual dysfunction	57.48	22.39	27	6846	6276	34943782
Major depression	55.77	22.39	24	6849	4548	34945510
Feeling abnormal	55.15	22.39	65	6808	63170	34886888
Completed suicide	54.76	22.39	81	6792	98087	34851971
Insomnia	54.07	22.39	83	6790	103824	34846234
Withdrawal syndrome	50.20	22.39	31	6842	12424	34937634
Anger	48.97	22.39	30	6843	11854	34938204
Panic attack	41.93	22.39	25	6848	9407	34940651
Schizophreniform disorder	41.87	22.39	8	6865	72	34949986
Depression	40.23	22.39	70	6803	97028	34853030
Thinking abnormal	40.23	22.39	21	6852	6116	34943942
Drug ineffective	39.18	22.39	185	6688	456566	34493492
Nervousness	37.63	22.39	26	6847	12580	34937478
Erectile dysfunction	34.13	22.39	30	6843	20607	34929451
Coma scale abnormal	32.98	22.39	16	6857	3992	34946066
Drug interaction	30.01	22.39	105	6768	225841	34724217
Crying	29.92	22.39	17	6856	5845	34944213
Mania	29.29	22.39	20	6853	9491	34940567
Tremor	28.45	22.39	55	6818	82532	34867526
Libido decreased	27.76	22.39	15	6858	4681	34945377
Irritability	27.73	22.39	29	6844	24661	34925397
Dizziness	27.68	22.39	100	6773	218421	34731637
Drug screen positive	27.30	22.39	14	6859	3929	34946129
Headache	26.42	22.39	93	6780	200542	34749516
Dry mouth	26.25	22.39	31	6842	30134	34919924
Abnormal behaviour	25.70	22.39	28	6845	24941	34925117
Emotional disorder	25.01	22.39	15	6858	5701	34944357
Drug screen false positive	24.22	22.39	8	6865	731	34949327
Paralysis	24.15	22.39	15	6858	6067	34943991
Condition aggravated	22.68	22.39	86	6787	192110	34757948
Bipolar disorder	22.47	22.39	12	6861	3657	34946401

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Withdrawal syndrome	287.74	14.44	140	20506	26714	79697028
Suicidal ideation	238.02	14.44	180	20466	76160	79647582
Drug withdrawal syndrome	237.42	14.44	134	20512	34584	79689158
Feeling abnormal	223.24	14.44	239	20407	158960	79564782
Product residue present	191.96	14.44	60	20586	3476	79720266
Anxiety	191.35	14.44	276	20370	248236	79475506
Crying	190.92	14.44	101	20545	22942	79700800
Serotonin syndrome	169.39	14.44	119	20527	44908	79678834
Irritability	134.79	14.44	100	20546	41044	79682698
Overdose	125.01	14.44	193	20453	184013	79539729
Anger	111.25	14.44	64	20582	17098	79706644
Completed suicide	110.96	14.44	215	20431	245552	79478190
Suicide attempt	109.93	14.44	121	20525	82811	79640931
Insomnia	99.30	14.44	205	20441	244965	79478777
Depression	88.62	14.44	182	20464	216608	79507134
Panic attack	84.13	14.44	61	20585	24155	79699587
Hyperhidrosis	84.08	14.44	145	20501	151347	79572395
Emotional disorder	81.04	14.44	49	20597	14338	79709404
Dizziness	80.95	14.44	309	20337	526132	79197610
Coma scale abnormal	68.93	14.44	37	20609	8641	79715101
Nervousness	66.86	14.44	61	20585	33354	79690388
Tremor	66.19	14.44	140	20506	169943	79553799
Persistent genital arousal disorder	65.01	14.44	15	20631	266	79723476
Headache	63.63	14.44	335	20311	653437	79070305
Nausea	61.32	14.44	440	20206	956756	78766986
Drug ineffective	59.81	14.44	480	20166	1080433	78643309
Intentional product misuse	59.33	14.44	96	20550	95069	79628673
Product substitution issue	59.17	14.44	46	20600	20210	79703532
Depressed mood	57.84	14.44	67	20579	48413	79675329
Drug hypersensitivity	54.78	14.44	186	20460	298730	79425012
Thinking abnormal	54.68	14.44	37	20609	13124	79710618
Major depression	54.25	14.44	32	20614	8948	79714794
Acute kidney injury	51.27	14.44	36	20610	519368	79204374
Nightmare	47.47	14.44	45	20601	25816	79697926
Abnormal dreams	47.21	14.44	32	20614	11380	79712362
Agitation	41.00	14.44	84	20562	99631	79624111
Impaired driving ability	39.98	14.44	22	20624	5393	79718349
Pre-existing condition improved	39.43	14.44	22	20624	5541	79718201
Dissociation	37.23	14.44	19	20627	4002	79719740
General physical health deterioration	36.22	14.44	13	20633	275225	79448517
Febrile neutropenia	35.78	14.44	8	20638	230991	79492751
Neutropenia	35.54	14.44	15	20631	287695	79436047
Anaemia	35.21	14.44	38	20608	444977	79278765
Feeling jittery	35.00	14.44	28	20618	12813	79710929
Thrombocytopenia	34.11	14.44	13	20633	265246	79458496
Schizophreniform disorder	33.86	14.44	8	20638	158	79723584
Mental disorder	33.60	14.44	41	20605	31261	79692481
Panic reaction	31.84	14.44	18	20628	4647	79719095
Pyrexia	31.44	14.44	82	20564	678627	79045115
Tinnitus	30.77	14.44	47	20599	44286	79679456
Mood altered	30.76	14.44	30	20616	17817	79705925
Migraine	30.56	14.44	69	20577	87424	79636318
Mania	30.18	14.44	30	20616	18230	79705512
Seizure	29.83	14.44	112	20534	188722	79535020
Therapeutic response unexpected	29.74	14.44	31	20615	19915	79703827
Abnormal behaviour	28.71	14.44	41	20605	36380	79687362
Tardive dyskinesia	28.71	14.44	23	20623	10548	79713194
Paranoia	28.61	14.44	30	20616	19402	79704340
Condition aggravated	28.29	14.44	224	20422	500900	79222842
Mood swings	28.05	14.44	30	20616	19850	79703892
Hostility	27.63	14.44	13	20633	2297	79721445
Disturbance in attention	27.32	14.44	48	20598	50753	79672989
Contraindicated product administered	25.32	14.44	5	20641	157533	79566209
Prescribed overdose	24.66	14.44	39	20607	37844	79685898
Frustration tolerance decreased	24.03	14.44	18	20628	7484	79716258
Synovitis	23.78	14.44	5	20641	150729	79573013
Yawning	23.78	14.44	10	20636	1356	79722386
Bipolar disorder	23.59	14.44	18	20628	7689	79716053
Memory impairment	23.55	14.44	73	20573	111661	79612081
Suicidal behaviour	23.45	14.44	13	20633	3234	79720508
Bruxism	23.41	14.44	14	20632	4012	79719730
Renal impairment	23.37	14.44	6	20640	157777	79565965
Hypersensitivity vasculitis	23.00	14.44	17	20629	6926	79716816
Drug effective for unapproved indication	22.87	14.44	16	20630	5985	79717757
Product dose omission issue	22.69	14.44	125	20521	247412	79476330
Drug dependence	22.55	14.44	39	20607	40730	79683012
Malignant neoplasm progression	22.53	14.44	4	20642	135986	79587756
Sepsis	22.42	14.44	22	20624	269406	79454336
Affect lability	21.44	14.44	20	20626	11239	79712503
Reversible cerebral vasoconstriction syndrome	21.42	14.44	12	20634	3045	79720697
Systemic lupus erythematosus	21.34	14.44	3	20643	121146	79602596
Sympathomimetic effect	21.15	14.44	5	20641	99	79723643
Multiple organ dysfunction syndrome	21.13	14.44	3	20643	120243	79603499
Renal failure	21.04	14.44	13	20633	200955	79522787
Aggression	21.02	14.44	43	20603	50915	79672827
Drug interaction	20.94	14.44	181	20465	415002	79308740
Product dispensing error	20.47	14.44	21	20625	13242	79710500
Drug screen positive	20.43	14.44	15	20631	6048	79717694
Malaise	19.93	14.44	204	20442	489665	79234077
Hypersomnia	19.70	14.44	27	20619	23059	79700683
Stress	19.62	14.44	55	20591	79557	79644185
Self-injurious ideation	19.48	14.44	12	20634	3626	79720116
Toxicity to various agents	19.32	14.44	180	20466	421360	79302382
Palpitations	19.08	14.44	74	20572	126536	79597206
False positive investigation result	18.89	14.44	8	20638	1104	79722638
Bradycardia	18.52	14.44	6	20640	135551	79588191
Wrong strength	18.18	14.44	5	20641	184	79723558
Paraesthesia	18.17	14.44	92	20554	176231	79547511
Energy increased	18.02	14.44	11	20635	3271	79720471
Therapeutic response changed	17.68	14.44	8	20638	1293	79722449
Septic shock	17.56	14.44	5	20641	122796	79600946
Wernicke-Korsakoff syndrome	17.39	14.44	4	20642	70	79723672
Mental impairment	17.37	14.44	23	20623	19013	79704729
Hypertensive emergency	17.02	14.44	10	20636	2775	79720967
Amnesia	16.97	14.44	45	20601	63012	79660730
Ankyloglossia congenital	16.95	14.44	3	20643	12	79723730
Change in seizure presentation	16.90	14.44	6	20640	516	79723226
Tachyphrenia	16.89	14.44	9	20637	2071	79721671
Emotional distress	16.81	14.44	34	20612	39935	79683807
Impaired work ability	16.77	14.44	23	20623	19658	79704084
Ejaculation disorder	16.71	14.44	6	20640	533	79723209
Impulsive behaviour	16.65	14.44	10	20636	2890	79720852
Dysphoria	16.61	14.44	12	20634	4722	79719020
Joint swelling	16.50	14.44	31	20615	288615	79435127
Somnolence	16.40	14.44	112	20534	238869	79484873
Obsessive-compulsive disorder	16.32	14.44	13	20633	5914	79717828
Vertigo	16.32	14.44	47	20599	69035	79654707
Blood pressure orthostatic	16.27	14.44	4	20642	94	79723648
Hypotension	16.21	14.44	59	20587	440258	79283484
Stomatitis	16.05	14.44	9	20637	146748	79576994
Death	15.95	14.44	84	20562	566430	79157312
Hyperkalaemia	15.74	14.44	5	20641	114393	79609349
Brain injury	15.58	14.44	17	20629	11500	79712242
Lower respiratory tract infection	15.52	14.44	7	20639	129213	79594529
C-reactive protein increased	15.48	14.44	7	20639	129020	79594722
Paralysis	15.35	14.44	18	20628	13159	79710583
Dyspnoea	15.34	14.44	145	20501	856880	78866862
Insulinoma	15.09	14.44	4	20642	128	79723614
Intestinal pseudo-obstruction	14.98	14.44	9	20637	2600	79721142
Anorgasmia	14.82	14.44	7	20639	1247	79722495
Blood pressure increased	14.46	14.44	99	20547	211261	79512481

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	N06AX23	NERVOUS SYSTEM PSYCHOANALEPTICS ANTIDEPRESSANTS Other antidepressants
FDA MoA	N0000000102	Norepinephrine Uptake Inhibitors
FDA MoA	N0000000109	Serotonin Uptake Inhibitors
MeSH PA	D000928	Antidepressive Agents
MeSH PA	D002491	Central Nervous System Agents
MeSH PA	D049990	Membrane Transport Modulators
MeSH PA	D018377	Neurotransmitter Agents
MeSH PA	D014179	Neurotransmitter Uptake Inhibitors
MeSH PA	D011619	Psychotropic Drugs
MeSH PA	D000068760	Serotonin and Noradrenaline Reuptake Inhibitors
FDA EPC	N0000175749	Serotonin and Norepinephrine Reuptake Inhibitor
FDA MoA	N0000182137	Cytochrome P450 2D6 Inhibitors
CHEBI has role	CHEBI:35469	antidepressants
CHEBI has role	CHEBI:49103	drug metabolites
CHEBI has role	CHEBI:83399	marine xenobiotic metabolites

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Major depressive disorder	indication	370143000
Generalized anxiety disorder	off-label use	21897009	DOID:14320
Social phobia	off-label use	25501002	DOID:11257
Menopausal flushing	off-label use	198436008
Neuropathic pain	off-label use	247398009
Panic disorder	off-label use	371631005	DOID:594
Ocular hypertension	contraindication	4210003	DOID:9282
Suicidal thoughts	contraindication	6471006
Hypercholesterolemia	contraindication	13644009
Bipolar disorder	contraindication	13746004	DOID:3312
Neuroleptic malignant syndrome	contraindication	15244003	DOID:14464
Hypertensive disorder	contraindication	38341003	DOID:10763
Disorder of cardiovascular system	contraindication	49601007	DOID:1287
Syndrome of inappropriate vasopressin secretion	contraindication	55004003	DOID:3401
Cerebrovascular disease	contraindication	62914000	DOID:6713
Blood coagulation disorder	contraindication	64779008	DOID:1247
Hyponatremia	contraindication	89627008
Seizure disorder	contraindication	128613002
Bleeding	contraindication	131148009
Impaired renal function disorder	contraindication	197663003
Mania	contraindication	231494001
Hypomania	contraindication	231496004
Interstitial lung disease	contraindication	233703007	DOID:3082
Disease of liver	contraindication	235856003	DOID:409
Hypertriglyceridemia	contraindication	302870006
Serotonin syndrome	contraindication	371089000
Angle-closure glaucoma	contraindication	392291006	DOID:13550
Myocardial infarction in recovery phase	contraindication	418044006
Hypertensive urgency	contraindication	443482000

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	10.79	acidic
pKa2	9.33	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source	MoA source
Sodium-dependent serotonin transporter	Transporter	P31645	SC6A4_HUMAN	INHIBITOR	Ki	7.33	WOMBAT-PK	CHEMBL
Sodium-dependent noradrenaline transporter	Transporter	P23975	SC6A2_HUMAN	INHIBITOR	Ki	6.28	WOMBAT-PK	CHEMBL
Alpha-1A adrenergic receptor	GPCR		ADA1A_RAT		IC50	7.22	CHEMBL

External reference:

ID	Source
D07793	KEGG_DRUG
4027338	VUID
N0000176142	NUI
386750-22-7	SECONDARY_CAS_RN
4027338	VANDF
C1880288	UMLSCUI
CHEBI:83527	CHEBI
CHEMBL1118	ChEMBL_ID
CHEMBL1201728	ChEMBL_ID
DB06700	DRUGBANK_ID
7158	IUPHAR_LIGAND_ID
8361	INN_ID
93414-04-1	SECONDARY_CAS_RN
NG99554ANW	UNII
125017	PUBCHEM_CID
683693	RXNORM
132507	MMSL
200628	MMSL
25184	MMSL
339716	MMSL
38906	MMSL
d07113	MMSL
012574	NDDF
012575	NDDF
015249	NDDF
430267008	SNOMEDCT_US
430271006	SNOMEDCT_US
433292007	SNOMEDCT_US
D000069468	MESH_DESCRIPTOR_UI
CHEMBL3989861	ChEMBL_ID

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Pristiq Extended-Release	HUMAN PRESCRIPTION DRUG LABEL	1	0008-1210	TABLET, EXTENDED RELEASE	25 mg	ORAL	NDA	31 sections
Pristiq Extended-Release	HUMAN PRESCRIPTION DRUG LABEL	1	0008-1210	TABLET, EXTENDED RELEASE	25 mg	ORAL	NDA	31 sections
Pristiq Extended-Release	HUMAN PRESCRIPTION DRUG LABEL	1	0008-1210	TABLET, EXTENDED RELEASE	25 mg	ORAL	NDA	31 sections
Pristiq Extended-Release	HUMAN PRESCRIPTION DRUG LABEL	1	0008-1211	TABLET, EXTENDED RELEASE	50 mg	ORAL	NDA	31 sections
Pristiq Extended-Release	HUMAN PRESCRIPTION DRUG LABEL	1	0008-1211	TABLET, EXTENDED RELEASE	50 mg	ORAL	NDA	31 sections
Pristiq Extended-Release	HUMAN PRESCRIPTION DRUG LABEL	1	0008-1211	TABLET, EXTENDED RELEASE	50 mg	ORAL	NDA	31 sections
Pristiq Extended-Release	HUMAN PRESCRIPTION DRUG LABEL	1	0008-1222	TABLET, EXTENDED RELEASE	100 mg	ORAL	NDA	31 sections
Pristiq Extended-Release	HUMAN PRESCRIPTION DRUG LABEL	1	0008-1222	TABLET, EXTENDED RELEASE	100 mg	ORAL	NDA	31 sections
Pristiq Extended-Release	HUMAN PRESCRIPTION DRUG LABEL	1	0008-1222	TABLET, EXTENDED RELEASE	100 mg	ORAL	NDA	31 sections
Desvenlafaxine	HUMAN PRESCRIPTION DRUG LABEL	1	0054-0400	TABLET, FILM COATED, EXTENDED RELEASE	50 mg	ORAL	ANDA	30 sections
Desvenlafaxine	HUMAN PRESCRIPTION DRUG LABEL	1	0054-0400	TABLET, FILM COATED, EXTENDED RELEASE	50 mg	ORAL	ANDA	30 sections
Desvenlafaxine	HUMAN PRESCRIPTION DRUG LABEL	1	0054-0401	TABLET, FILM COATED, EXTENDED RELEASE	100 mg	ORAL	ANDA	30 sections
Desvenlafaxine	HUMAN PRESCRIPTION DRUG LABEL	1	0054-0401	TABLET, FILM COATED, EXTENDED RELEASE	100 mg	ORAL	ANDA	30 sections
Desvenlafaxine	HUMAN PRESCRIPTION DRUG LABEL	1	0054-0603	TABLET, FILM COATED, EXTENDED RELEASE	25 mg	ORAL	ANDA	30 sections
Desvenlafaxine	HUMAN PRESCRIPTION DRUG LABEL	1	0054-0603	TABLET, FILM COATED, EXTENDED RELEASE	25 mg	ORAL	ANDA	30 sections
Desvenlafaxine	HUMAN PRESCRIPTION DRUG LABEL	1	0591-3659	TABLET, EXTENDED RELEASE	50 mg	ORAL	ANDA	30 sections
Desvenlafaxine	HUMAN PRESCRIPTION DRUG LABEL	1	0591-3659	TABLET, EXTENDED RELEASE	50 mg	ORAL	ANDA	30 sections
Desvenlafaxine	HUMAN PRESCRIPTION DRUG LABEL	1	0591-3660	TABLET, EXTENDED RELEASE	100 mg	ORAL	ANDA	30 sections
Desvenlafaxine	HUMAN PRESCRIPTION DRUG LABEL	1	0591-3660	TABLET, EXTENDED RELEASE	100 mg	ORAL	ANDA	30 sections
Desvenlafaxine	HUMAN PRESCRIPTION DRUG LABEL	1	0591-4060	TABLET, EXTENDED RELEASE	25 mg	ORAL	ANDA	30 sections
Desvenlafaxine	HUMAN PRESCRIPTION DRUG LABEL	1	0591-4060	TABLET, EXTENDED RELEASE	25 mg	ORAL	ANDA	30 sections
Desvenlafaxine	Human Prescription Drug Label	1	35208-009	TABLET, EXTENDED RELEASE	50 mg	ORAL	ANDA	30 sections
Desvenlafaxine	Human Prescription Drug Label	1	35208-010	TABLET, EXTENDED RELEASE	100 mg	ORAL	ANDA	30 sections
PristiqExtended-Release	HUMAN PRESCRIPTION DRUG LABEL	1	43063-262	TABLET, EXTENDED RELEASE	50 mg	ORAL	NDA	31 sections
Desvenlafaxine	Human Prescription Drug Label	1	46708-152	TABLET, EXTENDED RELEASE	50 mg	ORAL	NDA	30 sections
Desvenlafaxine	Human Prescription Drug Label	1	46708-152	TABLET, EXTENDED RELEASE	50 mg	ORAL	NDA	30 sections
Desvenlafaxine	Human Prescription Drug Label	1	46708-153	TABLET, EXTENDED RELEASE	100 mg	ORAL	NDA	30 sections
Desvenlafaxine	Human Prescription Drug Label	1	46708-153	TABLET, EXTENDED RELEASE	100 mg	ORAL	NDA	30 sections
Desvenlafaxine	Human Prescription Drug Label	1	46708-540	TABLET, EXTENDED RELEASE	50 mg	ORAL	ANDA	30 sections
Desvenlafaxine	Human Prescription Drug Label	1	46708-540	TABLET, EXTENDED RELEASE	50 mg	ORAL	ANDA	30 sections