bifemelane 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
369 90293-01-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • bifemelane
  • 4-(o-Benzylphenoxy)-N-methylbutylamine
  • bifemelane hydrochloride
  • bifemelane HCl
  • Molecular weight: 269.39
  • Formula: C18H23NO
  • CLOGP: 3.97
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 1
  • TPSA: 21.26
  • ALOGS: -5.22
  • ROTB: 8

Drug dosage:

None

ADMET properties:

PropertyValueReference
BA (Bioavailability) 13 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,AKT1,AKT2,AKT3,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,ITK,JAK2,JAK3,MAP2K6,MAP3K7,MAPK10,MAPK12,MAPK7,MET,NTRK2,PAK4,PDK2,PDK4,PDPK1,PIM2,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK 43
kinase-selectivity-class AXL,GRK2,PDK4,SIK2 4
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N06AX08 NERVOUS SYSTEM
PSYCHOANALEPTICS
ANTIDEPRESSANTS
Other antidepressants
MeSH PA D000928 Antidepressive Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D011619 Psychotropic Drugs

Related Drugs by ATC class:

N06AX Other antidepressants 28 drugs
agomelatinebrexanolonebupropiondesvenlafaxinedextromethorphanduloxetineesketaminegepironelevomilnacipranmedifoxaminemianserinmilnacipran show all 28 →

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Cerebrovascular disease indication 62914000 DOID:6713




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 10.48 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Amine oxidase [flavin-containing] B Enzyme INHIBITOR Ki 4.34 IUPHAR
Amine oxidase [flavin-containing] A Enzyme INHIBITOR Ki 5.38 IUPHAR
Lethal(3)malignant brain tumor-like protein 1 Nuclear other IC50 4.04 CHEMBL

External reference:

IDSource
D01793 KEGG_DRUG
47111 RXNORM
C0106291 UMLSCUI
CHEBI:92338 CHEBI
CHEMBL1192517 ChEMBL_ID
DB13550 DRUGBANK_ID
C031906 MESH_SUPPLEMENTAL_RECORD_UI
2377 PUBCHEM_CID
11742 IUPHAR_LIGAND_ID
5902 INN_ID
62232-46-6 SECONDARY_CAS_RN
Z4501GN13G UNII
006415 NDDF
006416 NDDF
Z4501GN13G INXIGHT DRUGS

Pharmaceutical products:

None