acetylsalicylic acid 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
74 50-78-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • acetylsalisylic acid
  • aspirin
  • acetylsalicylic acid
  • aspirin sodium
  • aspirin magnesium
  • aspirin potassium
  • aspirin calcium
  • aspirin anhydride
  • aspirin lysine
The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
  • Molecular weight: 180.16
  • Formula: C9H8O4
  • CLOGP: 1.09
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 63.60
  • ALOGS: -2.09
  • ROTB: 3
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
1 tablet O
30 mg O
3 g O
1 g P
3 g R

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 4.60 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 1.40 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 370.22 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution) 0.22 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 12 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.68 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 0.26 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
April 12, 1950 FDA ENDO PHARMS
Jan. 1, 1898 YEAR INTRODUCED

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 1523.97 11.21 9193 932420 1035572 61511837
Gastrointestinal haemorrhage 1226.69 11.21 3293 938320 77883 62469526
Myocardial infarction 1048.35 11.21 3564 938049 96329 62451080
Cerebrovascular accident 770.48 11.21 3411 938202 104613 62442796
Acute myocardial infarction 685.88 11.21 1490 940123 30634 62516775
Treatment failure 681.61 11.21 1191 940422 197852 62349557
Labelled drug-drug interaction medication error 661.45 11.21 902 940711 12497 62534912
Coronary artery disease 658.77 11.21 1473 940140 30904 62516505
Off label use 629.32 11.21 6686 934927 667776 61879633
Alopecia 618.63 11.21 2738 938875 334798 62212611
Pemphigus 599.83 11.21 1132 940481 182594 62364815
Toxicity to various agents 569.85 11.21 5888 935725 241362 62306047
Systemic lupus erythematosus 564.24 11.21 1430 940183 207488 62339921
Cardiac failure congestive 528.64 11.21 2739 938874 89694 62457715
Completed suicide 515.04 11.21 3813 937800 141860 62405549
Psoriatic arthropathy 503.05 11.21 373 941240 91147 62456262
Glossodynia 454.34 11.21 1262 940351 177614 62369795
Product use issue 419.33 11.21 1763 939850 218757 62328652
Drug intolerance 415.45 11.21 2775 938838 305886 62241523
Device expulsion 391.46 11.21 34 941579 34888 62512521
Melaena 373.12 11.21 1144 940469 29221 62518188
Angina pectoris 362.91 11.21 1126 940487 28952 62518457
Aspirin-exacerbated respiratory disease 355.80 11.21 200 941413 695 62546714
Abdominal discomfort 352.32 11.21 3053 938560 317832 62229577
Hand deformity 348.15 11.21 1205 940408 158252 62389157
Contraindicated product administered 346.91 11.21 1854 939759 215794 62331615
Arthropathy 314.65 11.21 2113 939500 232679 62314730
Therapeutic product effect incomplete 288.06 11.21 923 940690 124133 62423276
Upper gastrointestinal haemorrhage 283.71 11.21 764 940849 18088 62529321
Synovitis 282.08 11.21 1621 939992 185297 62362112
Transient ischaemic attack 275.64 11.21 1201 940412 36552 62510857
Injection site pain 262.77 11.21 1012 940601 128788 62418621
Musculoskeletal stiffness 255.57 11.21 1645 939968 182973 62364436
Rhabdomyolysis 251.55 11.21 1303 940310 42648 62504761
Pain 248.50 11.21 8744 932869 731884 61815525
Angina unstable 246.12 11.21 405 941208 6690 62540719
Hypotension 244.29 11.21 5524 936089 267080 62280329
Plasma cell myeloma 235.80 11.21 1107 940506 34798 62512611
Wound 235.10 11.21 1437 940176 161826 62385583
Syncope 234.23 11.21 2718 938895 114667 62432742
Metabolic acidosis 230.07 11.21 1295 940318 43774 62503635
Acute hepatic failure 227.50 11.21 693 940920 17634 62529775
Atrial fibrillation 226.67 11.21 2687 938926 113949 62433460
Injection site reaction 223.87 11.21 325 941288 58199 62489210
Condition aggravated 218.68 11.21 4429 937184 397788 62149621
Vascular stent thrombosis 217.42 11.21 151 941462 826 62546583
Acute kidney injury 215.49 11.21 5271 936342 258144 62289265
Product use in unapproved indication 211.16 11.21 1671 939942 177409 62370000
Haematoma 210.97 11.21 1049 940564 33771 62513638
Fall 208.30 11.21 7438 934175 384896 62162513
Cerebral haemorrhage 205.15 11.21 952 940661 29777 62517632
Anaemia 195.13 11.21 5715 935898 287715 62259694
Lower gastrointestinal haemorrhage 194.15 11.21 388 941225 7502 62539907
Malignant neoplasm progression 193.35 11.21 600 941013 81521 62465888
Coronary arterial stent insertion 193.17 11.21 224 941389 2605 62544804
Fibromyalgia 192.60 11.21 583 941030 79837 62467572
Exposure to toxic agent 192.56 11.21 318 941295 5269 62542140
C-reactive protein abnormal 189.40 11.21 243 941370 45853 62501556
Haemoglobin decreased 187.34 11.21 3116 938497 142369 62405040
Injection site erythema 183.82 11.21 625 940988 82549 62464860
Haematemesis 183.39 11.21 915 940698 29497 62517912
Discomfort 181.36 11.21 1597 940016 165777 62381632
Hypoglycaemia 180.53 11.21 1515 940098 58550 62488859
Coronary artery occlusion 170.33 11.21 376 941237 7815 62539594
Swelling 166.49 11.21 2977 938636 272401 62275008
Coagulopathy 165.08 11.21 673 940940 19871 62527538
Myocardial ischaemia 151.96 11.21 478 941135 12381 62535028
Haemorrhage intracranial 150.56 11.21 490 941123 12929 62534480
Loss of personal independence in daily activities 150.29 11.21 837 940776 96453 62450956
Rheumatic fever 147.32 11.21 258 941355 42853 62504556
Febrile neutropenia 146.26 11.21 1091 940522 117358 62430051
Bradycardia 143.09 11.21 1689 939924 71538 62475871
Coronary artery stenosis 142.44 11.21 254 941359 4490 62542919
Disease progression 142.08 11.21 1151 940462 121607 62425802
Chest pain 142.02 11.21 4201 937412 211758 62335651
Pericarditis 141.39 11.21 1258 940355 130321 62417088
Coronary artery bypass 141.12 11.21 175 941438 2194 62545215
Haematochezia 140.99 11.21 1312 940301 52232 62495177
Anti-cyclic citrullinated peptide antibody positive 140.83 11.21 1076 940537 115136 62432273
Blood loss anaemia 140.72 11.21 370 941243 8631 62538778
Arthralgia 135.33 11.21 6989 934624 562721 61984688
Drug interaction 134.72 11.21 4397 937216 224734 62322675
Premature delivery 132.66 11.21 836 940777 29445 62517964
Duodenal ulcer 131.79 11.21 329 941284 7427 62539982
International normalised ratio increased 130.60 11.21 1154 940459 45271 62502138
Therapy non-responder 126.69 11.21 636 940977 75265 62472144
Gastric ulcer 126.20 11.21 696 940917 23341 62524068
Angioedema 126.13 11.21 1175 940438 46790 62500619
Swollen joint count increased 125.72 11.21 213 941400 35841 62511568
Acute coronary syndrome 123.91 11.21 381 941232 9745 62537664
Haemorrhage 123.46 11.21 1417 940196 59605 62487804
Rheumatoid factor positive 122.42 11.21 741 940872 83665 62463744
Rectal haemorrhage 121.94 11.21 1187 940426 47843 62499566
Product administration error 116.58 11.21 647 940966 21750 62525659
Overdose 115.72 11.21 2372 939241 112706 62434703
Injection site swelling 115.23 11.21 343 941270 47229 62500180
Thrombosis in device 115.13 11.21 179 941434 2811 62544598
Hyponatraemia 111.69 11.21 2304 939309 109596 62437813
Injection site pruritus 111.67 11.21 322 941291 44794 62502615
Therapeutic product effect decreased 110.87 11.21 2107 939506 191080 62356329
Myelosuppression 110.32 11.21 113 941500 23590 62523819
Anion gap 110.19 11.21 116 941497 1201 62546208
Hip arthroplasty 109.40 11.21 352 941261 47294 62500115
Subdural haematoma 109.33 11.21 462 941151 13866 62533543
Hospitalisation 107.24 11.21 779 940834 84302 62463107
Adverse event 104.98 11.21 580 941033 66979 62480430
Knee arthroplasty 104.94 11.21 430 941183 53776 62493633
Epistaxis 103.84 11.21 1585 940028 71140 62476269
Blood pressure increased 103.62 11.21 3142 938471 158920 62388489
Wrong technique in product usage process 103.11 11.21 524 941089 61816 62485593
Prescribed overdose 102.27 11.21 221 941392 33932 62513477
Blood pressure fluctuation 101.66 11.21 1093 940520 45224 62502185
Suicidal ideation 100.81 11.21 529 941084 61892 62485517
Cerebral infarction 99.95 11.21 652 940961 23241 62524168
Mucosal inflammation 98.73 11.21 360 941253 46568 62500841
Asthenia 98.03 11.21 6774 934839 376830 62170579
Liver injury 94.90 11.21 518 941095 60002 62487407
Deafness transitory 94.78 11.21 131 941482 1839 62545570
Hemiparesis 94.77 11.21 631 940982 22651 62524758
Maternal exposure during pregnancy 94.16 11.21 2513 939100 217549 62329860
Thrombosis 92.72 11.21 1412 940201 63343 62484066
Full blood count decreased 91.13 11.21 680 940933 25344 62522065
Therapeutic response decreased 90.86 11.21 537 941076 60988 62486421
Carotid artery stenosis 90.69 11.21 222 941391 4948 62542461
Vascular stent stenosis 90.45 11.21 71 941542 482 62546927
Grip strength decreased 89.99 11.21 119 941494 22168 62525241
Deep vein thrombosis postoperative 88.58 11.21 29 941584 11340 62536069
Vascular pseudoaneurysm 87.68 11.21 111 941502 1423 62545986
Joint swelling 87.54 11.21 3969 937644 323697 62223712
Lactic acidosis 87.54 11.21 911 940702 37376 62510033
Breast cancer stage II 86.68 11.21 13 941600 8723 62538686
Accidental exposure to product 86.56 11.21 172 941441 27233 62520176
Therapy interrupted 86.03 11.21 224 941389 32231 62515178
Retroperitoneal haemorrhage 85.58 11.21 151 941462 2646 62544763
Diverticulum intestinal haemorrhagic 84.58 11.21 110 941503 1451 62545958
Migraine 84.18 11.21 1054 940559 102292 62445117
Gastric ulcer haemorrhage 83.19 11.21 208 941405 4700 62542709
Ischaemic stroke 82.57 11.21 502 941111 17455 62529954
Duodenal ulcer perforation 82.54 11.21 860 940753 86349 62461060
Rash 81.66 11.21 7185 934428 553686 61993723
Orthostatic hypotension 81.54 11.21 858 940755 35302 62512107
Device dislocation 81.48 11.21 161 941452 25544 62521865
Joint stiffness 81.13 11.21 332 941281 41537 62505872
Confusional state 80.73 11.21 4283 937330 232097 62315312
Duodenal ulcer haemorrhage 80.47 11.21 137 941476 2330 62545079
Sinus bradycardia 80.22 11.21 427 941186 14124 62533285
Device difficult to use 80.03 11.21 45 941568 12751 62534658
Drug resistance 78.57 11.21 137 941476 22796 62524613
Arteriosclerosis coronary artery 78.47 11.21 288 941325 8085 62539324
Type 2 diabetes mellitus 78.46 11.21 589 941024 63279 62484130
Drug hypersensitivity 78.44 11.21 3786 937827 306901 62240508
Neoplasm progression 78.26 11.21 277 941336 36151 62511258
Psoriasis 77.68 11.21 869 940744 86088 62461321
Coronary artery thrombosis 77.46 11.21 90 941523 1049 62546360
Cardiac arrest 77.03 11.21 1857 939756 90688 62456721
Pregnancy 76.56 11.21 284 941329 36552 62510857
Arteriosclerosis 76.36 11.21 324 941289 9742 62537667
Hemiplegia 76.16 11.21 307 941306 9016 62538393
Helicobacter infection 75.67 11.21 946 940667 91839 62455570
Pericardial haemorrhage 75.42 11.21 106 941507 1513 62545896
Mitral valve incompetence 74.96 11.21 523 941090 19071 62528338
Haemorrhagic transformation stroke 74.81 11.21 92 941521 1143 62546266
Constipation 74.66 11.21 4065 937548 220878 62326531
Hypersensitivity 73.22 11.21 3570 938043 289115 62258294
Haemorrhagic stroke 72.80 11.21 220 941393 5572 62541837
Gastritis erosive 72.75 11.21 226 941387 5813 62541596
Product prescribing error 72.66 11.21 651 940962 25638 62521771
Internal haemorrhage 72.43 11.21 204 941409 4961 62542448
Hyperkalaemia 71.56 11.21 1166 940447 53037 62494372
Retroperitoneal haematoma 71.37 11.21 143 941470 2770 62544639
No adverse event 71.36 11.21 343 941270 41062 62506347
Autoimmune disorder 71.12 11.21 90 941523 17087 62530322
Product dose omission issue 70.54 11.21 2800 938813 231513 62315896
Intentional product misuse 70.16 11.21 1282 940331 59635 62487774
Dehydration 69.58 11.21 3191 938422 170163 62377246
Retinitis 69.52 11.21 6 941607 6190 62541219
Heart rate decreased 68.94 11.21 1003 940610 44557 62502852
Breast cancer stage III 68.68 11.21 34 941579 10352 62537057
Hepatic enzyme increased 68.44 11.21 2384 939229 199944 62347465
Drug ineffective for unapproved indication 67.32 11.21 268 941345 33795 62513614
Device issue 67.04 11.21 159 941454 23622 62523787
Depressed level of consciousness 66.86 11.21 1293 940320 60785 62486624
Breast cancer stage I 66.66 11.21 11 941602 6878 62540531
Blood cholesterol increased 66.14 11.21 988 940625 93044 62454365
Wheezing 65.68 11.21 1009 940604 94586 62452823
Shock haemorrhagic 65.63 11.21 306 941307 9589 62537820
Gastrointestinal toxicity 65.34 11.21 17 941596 7724 62539685
Lacunar infarction 65.32 11.21 148 941465 3132 62544277
Adjustment disorder with depressed mood 65.10 11.21 35 941578 10169 62537240
Rheumatoid nodule 64.87 11.21 96 941517 17059 62530350
Carotid artery thrombosis 64.71 11.21 134 941479 2660 62544749
Haematotoxicity 64.60 11.21 29 941584 9347 62538062
Foot deformity 64.48 11.21 205 941408 27648 62519761
Metastases to liver 63.54 11.21 162 941451 23477 62523932
Subarachnoid haemorrhage 62.97 11.21 395 941218 13888 62533521
Neurologic neglect syndrome 62.44 11.21 130 941483 2591 62544818
Infection 61.95 11.21 2772 938841 226401 62321008
Joint range of motion decreased 61.05 11.21 260 941353 32168 62515241
Mobility decreased 60.97 11.21 1350 940263 119809 62427600
Unintentional medical device removal 60.90 11.21 9 941604 6106 62541303
Cytomegalovirus infection 60.74 11.21 138 941475 20814 62526595
Faeces discoloured 60.54 11.21 476 941137 18033 62529376
Inflammation 60.47 11.21 857 940756 81416 62465993
Spinal epidural haematoma 60.42 11.21 79 941534 1048 62546361
Facet joint syndrome 59.81 11.21 55 941558 12083 62535326
Drug abuse 59.64 11.21 738 940875 71780 62475629
Hepatic cirrhosis 59.42 11.21 179 941434 24555 62522854
Extradural haematoma 59.33 11.21 98 941515 1624 62545785
Product monitoring error 59.10 11.21 174 941439 4342 62543067
Ankylosing spondylitis 58.41 11.21 42 941571 10432 62536977
Renal failure 58.41 11.21 2215 939398 115437 62431972
Hypertensive emergency 58.10 11.21 102 941511 1780 62545629
Infective pulmonary exacerbation of cystic fibrosis 58.09 11.21 29 941584 8788 62538621
Haematuria 58.03 11.21 675 940938 28482 62518927
Peripheral arterial occlusive disease 58.00 11.21 165 941448 4036 62543373
Blood creatinine increased 57.42 11.21 1708 939905 86136 62461273
Blood creatine phosphokinase increased 57.28 11.21 697 940916 29733 62517676
Palmar-plantar erythrodysaesthesia syndrome 57.14 11.21 164 941449 22851 62524558
Osteoarthritis 57.09 11.21 1032 940581 94311 62453098
Lupus vulgaris 57.05 11.21 10 941603 5984 62541425
Chronic obstructive pulmonary disease 56.83 11.21 1273 940340 61413 62485996
Post procedural haematoma 56.72 11.21 82 941531 1203 62546206
Abortion spontaneous 56.19 11.21 439 941174 46756 62500653
Coronary artery restenosis 55.79 11.21 46 941567 338 62547071
Metastases to bone 55.76 11.21 145 941468 20874 62526535
Neurotoxicity 55.08 11.21 105 941508 16885 62530524
Asthma 54.95 11.21 1455 940158 126106 62421303
Neutropenia 53.57 11.21 2087 939526 172918 62374491
Ecchymosis 53.47 11.21 314 941299 10780 62536629
Presyncope 53.43 11.21 639 940974 27146 62520263
Abdominal wall haematoma 53.39 11.21 131 941482 2924 62544485
Lip dry 53.37 11.21 92 941521 15378 62532031
Intraventricular haemorrhage 53.06 11.21 105 941508 2015 62545394
Heart rate irregular 52.92 11.21 537 941076 21884 62525525
Post procedural haemorrhage 52.61 11.21 246 941367 7718 62539691
Haemorrhagic arteriovenous malformation 52.51 11.21 31 941582 121 62547288
Injection site rash 51.25 11.21 128 941485 18681 62528728
Blood urea increased 50.87 11.21 607 941006 25772 62521637
C-reactive protein increased 50.63 11.21 1045 940568 93662 62453747
Analgesic drug level increased 50.59 11.21 110 941503 2262 62545147
Incorrect route of product administration 50.52 11.21 222 941391 27230 62520179
Cerebellar haemorrhage 50.29 11.21 81 941532 1313 62546096
Vascular graft 50.01 11.21 62 941551 777 62546632
COVID-19 49.79 11.21 1286 940327 111817 62435592
Hypophagia 49.62 11.21 694 940919 30565 62516844
Unintended pregnancy 49.50 11.21 15 941598 6164 62541245
Haemoptysis 49.39 11.21 647 940966 28079 62519330
Haemophagocytic lymphohistiocytosis 49.07 11.21 51 941562 10576 62536833
Intentional self-injury 48.94 11.21 205 941408 25482 62521927
Uterine perforation 48.82 11.21 21 941592 6942 62540467
Peripheral ischaemia 48.45 11.21 171 941442 4707 62542702
Lupus-like syndrome 48.30 11.21 96 941517 15199 62532210
Complication of device insertion 48.17 11.21 26 941587 7538 62539871
Fear of injection 48.06 11.21 23 941590 7141 62540268
Obesity 47.70 11.21 255 941358 29697 62517712
Arthritis 47.65 11.21 1331 940282 114590 62432819
Cardiac failure 47.58 11.21 1692 939921 87450 62459959
Lung disorder 47.37 11.21 644 940969 61617 62485792
Pneumocystis jirovecii pneumonia 46.96 11.21 114 941499 16800 62530609
Febrile bone marrow aplasia 46.91 11.21 25 941588 7300 62540109
Device malfunction 46.75 11.21 124 941489 17733 62529676
Medication error 46.52 11.21 1059 940554 51225 62496184
Ischaemia 46.29 11.21 166 941447 4606 62542803
Stent placement 45.68 11.21 141 941472 3614 62543795
Breast cancer female 45.54 11.21 82 941531 13477 62533932
Epstein-Barr virus infection 45.26 11.21 32 941581 8018 62539391
Creatinine renal clearance decreased 45.15 11.21 404 941209 15904 62531505
Injection site warmth 44.93 11.21 99 941514 15096 62532313
Cardiac disorder 44.82 11.21 1028 940585 49788 62497621
Subdural haemorrhage 44.56 11.21 124 941489 2994 62544415
Lower limb fracture 44.50 11.21 196 941417 24025 62523384
Multiple-drug resistance 44.32 11.21 11 941602 5159 62542250
Adjustment disorder 44.05 11.21 125 941488 3053 62544356
Red blood cell sedimentation rate increased 43.98 11.21 428 941185 43554 62503855
Product quality issue 43.92 11.21 331 941282 35534 62511875
Surgery 43.71 11.21 332 941281 35580 62511829
Atrioventricular block 43.25 11.21 226 941387 7421 62539988
Neuroleptic malignant syndrome 43.17 11.21 70 941543 11986 62535423
Mood swings 43.16 11.21 133 941480 18115 62529294
Dizziness 42.97 11.21 7128 934485 422797 62124612
Pulmonary toxicity 42.96 11.21 46 941567 9409 62538000
Acute myeloid leukaemia 42.71 11.21 122 941491 17025 62530384
Atrioventricular block complete 42.70 11.21 238 941375 8013 62539396
Device use error 42.64 11.21 16 941597 5745 62541664
Blood glucose decreased 42.57 11.21 487 941126 20465 62526944
Transplant dysfunction 42.48 11.21 10 941603 4862 62542547
Coordination abnormal 42.22 11.21 349 941264 13424 62533985
Therapy partial responder 41.93 11.21 58 941555 10600 62536809
Urinary tract infection 41.40 11.21 4508 937105 260176 62287233
Prothrombin time prolonged 41.23 11.21 263 941350 9301 62538108
Gastric haemorrhage 41.07 11.21 196 941417 6202 62541207
Acute graft versus host disease 40.83 11.21 8 941605 4420 62542989
Granuloma skin 40.67 11.21 39 941574 8398 62539011
Joint destruction 40.54 11.21 21 941592 6231 62541178
Sinus node dysfunction 40.47 11.21 157 941456 4528 62542881
Pulmonary fibrosis 40.39 11.21 386 941227 39423 62507986
Rheumatoid arthritis 40.02 11.21 3230 938383 250589 62296820
Amenorrhoea 39.96 11.21 53 941560 9861 62537548
Bone marrow failure 39.94 11.21 262 941351 29028 62518381
X-ray abnormal 39.66 11.21 37 941576 8073 62539336
Hepatic necrosis 39.29 11.21 178 941435 5509 62541900
Dislocation of vertebra 39.25 11.21 42 941571 8593 62538816
Gastrointestinal vascular malformation haemorrhagic 39.22 11.21 30 941583 195 62547214
Muscle spasticity 39.21 11.21 495 941118 21299 62526110
Anti-cyclic citrullinated peptide antibody 39.15 11.21 26 941587 6732 62540677
Blood calcium decreased 39.10 11.21 580 941033 25871 62521538
Disability 39.08 11.21 140 941473 18207 62529202
Injection site urticaria 38.95 11.21 95 941518 13978 62533431
Ischaemic cardiomyopathy 38.90 11.21 102 941511 2375 62545034
Balance disorder 38.75 11.21 1576 940037 82846 62464563
Multiple sclerosis relapse 38.49 11.21 497 941116 47981 62499428
Acidosis 38.47 11.21 292 941321 10941 62536468
Blood pressure decreased 38.44 11.21 1249 940364 63773 62483636
Acute lung injury 38.34 11.21 77 941536 1494 62545915
Intentional product use issue 38.29 11.21 1529 940084 126363 62421046
Cerebral ischaemia 38.16 11.21 199 941414 6529 62540880
Intermittent claudication 37.77 11.21 84 941529 1755 62545654
Intentional overdose 37.74 11.21 1400 940213 72752 62474657
Cataract 37.73 11.21 1111 940502 55942 62491467
Drug tolerance decreased 37.44 11.21 133 941480 17340 62530069
Personality disorder 37.29 11.21 178 941435 5633 62541776
Accidental overdose 37.20 11.21 518 941095 22791 62524618
Pyroglutamate increased 37.18 11.21 39 941574 402 62547007
Exposure during pregnancy 37.14 11.21 1906 939707 153641 62393768
Ventricular fibrillation 37.07 11.21 302 941311 11565 62535844
Arterial stenosis 36.89 11.21 45 941568 554 62546855
Low birth weight baby 36.47 11.21 205 941408 6924 62540485
Metastases to lung 36.14 11.21 85 941528 12665 62534744
Blood glucose increased 36.05 11.21 1553 940060 82203 62465206
Arterial haemorrhage 35.91 11.21 79 941534 1638 62545771
Peripheral venous disease 35.76 11.21 114 941499 15363 62532046
Aphasia 35.75 11.21 688 940925 32312 62515097
Metastases to lymph nodes 35.63 11.21 41 941572 8117 62539292
Colitis microscopic 35.56 11.21 249 941364 9090 62538319
Panniculitis 35.49 11.21 72 941541 11313 62536096
Sleep disorder 35.47 11.21 929 940684 80637 62466772
Adverse drug reaction 35.44 11.21 905 940708 78809 62468600
Pharyngeal haemorrhage 35.28 11.21 43 941570 529 62546880
Blood pressure diastolic decreased 35.19 11.21 502 941111 22204 62525205
Coronary artery aneurysm 35.17 11.21 15 941598 22 62547387
Coronary artery dissection 35.16 11.21 53 941560 809 62546600
Heparin-induced thrombocytopenia 35.16 11.21 148 941465 4434 62542975
Myalgia 35.13 11.21 2575 939038 143954 62403455
Renal impairment 35.11 11.21 1625 939988 86730 62460679
Metastases to central nervous system 35.08 11.21 90 941523 13015 62534394
Pulmonary oedema 35.06 11.21 1064 940549 53809 62493600
Spinal cord haemorrhage 34.97 11.21 29 941584 215 62547194
Chronic graft versus host disease 34.82 11.21 3 941610 3099 62544310
Myopathy 34.53 11.21 284 941329 10907 62536502
Interstitial lung disease 34.30 11.21 679 940934 61229 62486180
Carotid arteriosclerosis 34.22 11.21 60 941553 1046 62546363
Oesophageal intramural haematoma 34.08 11.21 20 941593 77 62547332
Hyperprolactinaemia 34.02 11.21 8 941605 3892 62543517
Blood parathyroid hormone decreased 33.99 11.21 58 941555 9733 62537676
Dyspnoea 33.88 11.21 10630 930983 650683 61896726
Peripheral vascular disorder 33.88 11.21 178 941435 5857 62541552
C-reactive protein 33.79 11.21 15 941598 4867 62542542
Urogenital haemorrhage 33.76 11.21 30 941583 247 62547162
Impaired quality of life 33.64 11.21 99 941514 13684 62533725
Hepatic failure 33.55 11.21 728 940885 34928 62512481
Traumatic haemorrhage 33.55 11.21 42 941571 532 62546877
Device breakage 33.48 11.21 76 941537 11466 62535943
Multiple injuries 33.47 11.21 79 941534 1719 62545690
Electrocardiogram ST segment elevation 33.43 11.21 131 941482 3796 62543613
Dysarthria 33.42 11.21 850 940763 41861 62505548
Oedema peripheral 33.36 11.21 3254 938359 186257 62361152
Posterior reversible encephalopathy syndrome 33.31 11.21 138 941475 17207 62530202
Injury 33.25 11.21 829 940784 72418 62474991
Systemic infection 33.06 11.21 147 941466 4513 62542896
Deformity 33.03 11.21 78 941535 11606 62535803
Graft versus host disease 32.91 11.21 31 941582 6732 62540677
Cardiovascular disorder 32.89 11.21 293 941320 11519 62535890
Ventricular hypertrophy 32.89 11.21 119 941494 3317 62544092
HELLP syndrome 32.77 11.21 57 941556 987 62546422
Pathogen resistance 32.72 11.21 28 941585 6370 62541039
Product storage error 32.61 11.21 113 941500 14843 62532566
Dystonia 32.48 11.21 101 941512 13718 62533691
Drug tolerance 32.48 11.21 33 941580 6916 62540493
Sinus arrest 32.41 11.21 82 941531 1867 62545542
Haematocrit decreased 32.30 11.21 788 940825 38552 62508857
Arterial occlusive disease 32.27 11.21 174 941439 5784 62541625
Graft versus host disease in skin 32.09 11.21 3 941610 2902 62544507
Ascites 31.80 11.21 419 941194 40309 62507100
Cardiogenic shock 31.72 11.21 406 941207 17526 62529883
Urine abnormality 31.50 11.21 195 941418 6824 62540585
Large intestinal haemorrhage 31.43 11.21 65 941548 1289 62546120
Swollen tongue 31.31 11.21 706 940907 34094 62513315
Cytomegalovirus viraemia 31.05 11.21 23 941590 5626 62541783
Spontaneous haematoma 31.01 11.21 51 941562 842 62546567
Myoglobin blood increased 30.93 11.21 66 941547 1339 62546070
Tenosynovitis 30.91 11.21 103 941510 13692 62533717
Gastritis 30.86 11.21 748 940865 36555 62510854
Complication of device removal 30.86 11.21 19 941594 5123 62542286
Small intestinal haemorrhage 30.69 11.21 84 941529 2008 62545401
Tricuspid valve incompetence 30.68 11.21 342 941271 14279 62533130
Labile blood pressure 30.51 11.21 76 941537 1713 62545696
Atrioventricular block second degree 30.48 11.21 127 941486 3787 62543622
Cystic fibrosis 30.30 11.21 6 941607 3290 62544119
Abortion incomplete 30.29 11.21 5 941608 3126 62544283
Aortic stenosis 30.23 11.21 151 941462 4869 62542540
Peripheral artery stenosis 30.11 11.21 41 941572 567 62546842
Mental status changes 30.09 11.21 785 940828 38814 62508595
Drug dose omission by device 29.86 11.21 17 941596 4784 62542625
Hip fracture 29.75 11.21 608 941005 28866 62518543
Microcytic anaemia 29.69 11.21 115 941498 3314 62544095
Aortic valve stenosis 29.68 11.21 112 941501 3187 62544222
Cognitive disorder 29.67 11.21 1059 940554 54756 62492653
Post transplant lymphoproliferative disorder 29.63 11.21 19 941594 5012 62542397
Puncture site haemorrhage 29.57 11.21 29 941584 274 62547135
Occult blood positive 29.30 11.21 120 941493 3550 62543859
Sexual dysfunction 29.23 11.21 14 941599 4345 62543064
Dyspnoea exertional 29.13 11.21 1132 940481 59170 62488239
Hypothermia 29.10 11.21 319 941294 13262 62534147
Body temperature increased 29.05 11.21 740 940873 36452 62510957
Gastrointestinal pain 29.05 11.21 246 941367 9530 62537879
Head injury 28.94 11.21 569 941044 26827 62520582
Eating disorder 28.91 11.21 419 941194 18597 62528812
Hepatic ischaemia 28.77 11.21 42 941571 622 62546787
Troponin increased 28.67 11.21 252 941361 9869 62537540
Anion gap abnormal 28.51 11.21 33 941580 383 62547026
Liver function test increased 28.47 11.21 330 941283 32481 62514928
Infusion related reaction 28.39 11.21 3197 938416 242324 62305085
Leukopenia 28.14 11.21 902 940711 76388 62471021
Unresponsive to stimuli 27.95 11.21 678 940935 33138 62514271
Brain herniation 27.62 11.21 118 941495 3559 62543850
Labile hypertension 27.51 11.21 35 941578 451 62546958
Sedation complication 27.51 11.21 320 941293 13502 62533907
Pregnancy with contraceptive device 27.27 11.21 18 941595 4676 62542733
Enthesopathy 27.26 11.21 54 941559 8560 62538849
Diverticulum 27.25 11.21 285 941328 11706 62535703
Drug dependence 27.19 11.21 232 941381 24251 62523158
Thrombotic microangiopathy 27.15 11.21 74 941539 10487 62536922
Bone erosion 27.03 11.21 153 941460 17564 62529845
Aneurysm 27.02 11.21 98 941515 2735 62544674
Oesophagitis haemorrhagic 26.84 11.21 35 941578 463 62546946
Electric shock 26.78 11.21 60 941553 1260 62546149
Pyrexia 26.74 11.21 6378 935235 464100 62083309
Withdrawal syndrome 26.70 11.21 180 941433 19817 62527592
Blood iron abnormal 26.69 11.21 12 941601 3864 62543545
Blood creatine phosphokinase MB increased 26.63 11.21 57 941556 1159 62546250
Renal artery stenosis 26.38 11.21 75 941538 1834 62545575
Dilatation atrial 26.33 11.21 77 941536 1914 62545495
Illness 26.30 11.21 541 941072 48518 62498891
Hepatitis B reactivation 26.27 11.21 7 941606 3130 62544279
Pulmonary renal syndrome 26.19 11.21 33 941580 421 62546988
Bundle branch block left 26.17 11.21 187 941426 6872 62540537
Diverticulitis intestinal haemorrhagic 26.14 11.21 19 941594 113 62547296
Immune reconstitution inflammatory syndrome 26.11 11.21 31 941582 6053 62541356
Human herpesvirus 6 infection 25.92 11.21 6 941607 2951 62544458
Drug withdrawal syndrome 25.79 11.21 268 941345 26926 62520483
Foetal growth restriction 25.67 11.21 196 941417 7357 62540052
Cerebrovascular disorder 25.62 11.21 94 941519 2638 62544771
Alanine aminotransferase increased 25.62 11.21 1828 939785 101942 62445467
Blood pressure systolic increased 25.62 11.21 901 940712 46496 62500913
Glycosylated haemoglobin increased 25.56 11.21 289 941324 12109 62535300
Oesophageal haemorrhage 25.50 11.21 36 941577 516 62546893
Galactorrhoea 25.43 11.21 15 941598 4140 62543269
Muscle haemorrhage 25.42 11.21 104 941509 3075 62544334
Blood potassium decreased 25.28 11.21 809 940804 41217 62506192
Cerebral haematoma 25.24 11.21 115 941498 3568 62543841
Joint dislocation 25.22 11.21 169 941444 18631 62528778
Anion gap increased 25.10 11.21 73 941540 1809 62545600
Respiratory arrest 25.05 11.21 648 940965 31997 62515412
Arrhythmia 25.02 11.21 742 940871 37398 62510011
Pallor 25.00 11.21 612 941001 29956 62517453
Venoocclusive liver disease 24.92 11.21 21 941592 4814 62542595
Normochromic normocytic anaemia 24.84 11.21 135 941478 4501 62542908
Hepatitis cholestatic 24.81 11.21 181 941432 6697 62540712
Osteoporosis 24.68 11.21 654 940959 56684 62490725
Colitis ischaemic 24.57 11.21 255 941358 10453 62536956
Haemodialysis 24.43 11.21 221 941392 8726 62538683
Abnormal loss of weight 24.31 11.21 158 941455 5624 62541785
Second primary malignancy 24.19 11.21 51 941562 7902 62539507
Haemorrhage subcutaneous 24.18 11.21 98 941515 2885 62544524
Product preparation error 24.12 11.21 33 941580 6059 62541350
Activated partial thromboplastin time prolonged 24.06 11.21 180 941433 6713 62540696
Paradoxical drug reaction 24.02 11.21 16 941597 4136 62543273
Graft versus host disease in gastrointestinal tract 23.99 11.21 9 941604 3232 62544177
Thalamus haemorrhage 23.96 11.21 40 941573 669 62546740
Arthrodesis 23.93 11.21 6 941607 2795 62544614
Diverticulum intestinal 23.83 11.21 176 941437 6537 62540872
Hypochromic anaemia 23.69 11.21 73 941540 1869 62545540
Left ventricular hypertrophy 23.44 11.21 147 941466 5168 62542241
Coronary angioplasty 23.39 11.21 16 941597 85 62547324
Circulatory collapse 23.30 11.21 456 941157 21482 62525927
Acute graft versus host disease in skin 23.28 11.21 11 941602 3441 62543968
Hyperlipidaemia 23.28 11.21 414 941199 19157 62528252
Pyroglutamic acidosis 23.05 11.21 37 941576 598 62546811
Laboratory test abnormal 22.98 11.21 542 941071 26370 62521039
Haemothorax 22.92 11.21 78 941535 2107 62545302
Heart rate increased 22.90 11.21 1658 939955 92580 62454829
Ischaemic cerebral infarction 22.77 11.21 57 941556 1289 62546120
Underdose 22.72 11.21 279 941334 27177 62520232
Sinusitis 22.71 11.21 3759 937854 222894 62324515
Bleeding time prolonged 22.66 11.21 38 941575 638 62546771
Cardiomegaly 22.54 11.21 377 941236 17237 62530172
Traumatic intracranial haemorrhage 22.50 11.21 32 941581 462 62546947
Blood prolactin increased 22.37 11.21 12 941601 3491 62543918
Pancytopenia 22.32 11.21 1192 940421 95741 62451668
Neoplasm malignant 22.30 11.21 310 941303 29551 62517858
Cardiac tamponade 22.28 11.21 134 941479 4641 62542768
Peripheral coldness 22.18 11.21 277 941336 11888 62535521
Functional gastrointestinal disorder 22.14 11.21 123 941490 4136 62543273
Electrocardiogram ST segment depression 22.13 11.21 93 941520 2784 62544625
Anuria 22.13 11.21 284 941329 12267 62535142
Deafness 22.12 11.21 382 941231 17575 62529834
Akathisia 22.10 11.21 66 941547 9080 62538329
Complication associated with device 22.09 11.21 154 941459 16824 62530585
Hepatorenal syndrome 22.08 11.21 71 941542 1861 62545548
Respiratory rate increased 22.06 11.21 304 941309 13344 62534065
Ovarian cyst 22.06 11.21 142 941471 15803 62531606
Aortic valve incompetence 21.84 11.21 158 941455 5830 62541579
Paraesthesia 21.67 11.21 2018 939595 154948 62392461
Flatulence 21.66 11.21 671 940942 34031 62513378
Retinal haemorrhage 21.64 11.21 137 941476 4832 62542577
Loss of consciousness 21.63 11.21 2034 939579 116087 62431322
Seizure 21.63 11.21 1683 939930 130951 62416458
Abortion early 21.57 11.21 10 941603 20 62547389
Electrolyte imbalance 21.56 11.21 418 941195 19658 62527751
Ventricular tachycardia 21.46 11.21 416 941197 19563 62527846
Dementia 21.45 11.21 395 941218 18399 62529010
Haemoperitoneum 21.39 11.21 89 941524 2652 62544757
Aspergillus infection 21.34 11.21 56 941557 8037 62539372
Bone density decreased 21.32 11.21 128 941485 14484 62532925
Device deployment issue 21.30 11.21 16 941597 3886 62543523
Body height decreased 21.27 11.21 236 941377 9842 62537567
Mucormycosis 21.21 11.21 8 941605 2863 62544546
Oesophageal mucosal dissection 21.18 11.21 9 941604 13 62547396
Iron deficiency anaemia 21.18 11.21 415 941198 19554 62527855
Pharyngitis 21.16 11.21 418 941195 19725 62527684
Gastrointestinal ulcer haemorrhage 21.10 11.21 37 941576 645 62546764
Sciatica 21.02 11.21 370 941243 33954 62513455
Deep vein thrombosis 20.82 11.21 1477 940136 82323 62465086
Potentiating drug interaction 20.81 11.21 123 941490 4233 62543176
Intracranial aneurysm 20.80 11.21 110 941503 3629 62543780
Renal papillary necrosis 20.79 11.21 23 941590 253 62547156
Blood immunoglobulin E increased 20.74 11.21 16 941597 3833 62543576
Embedded device 20.72 11.21 13 941600 3470 62543939
Angiopathy 20.60 11.21 128 941485 4485 62542924
Polyarthritis 20.58 11.21 79 941534 10067 62537342
Lethargy 20.54 11.21 1022 940591 54985 62492424
Haemorrhage urinary tract 20.43 11.21 41 941572 795 62546614
Subcutaneous haematoma 20.42 11.21 64 941549 1654 62545755
Adenovirus infection 20.34 11.21 14 941599 3557 62543852
Supraventricular extrasystoles 20.28 11.21 127 941486 4462 62542947
Procedural pain 20.27 11.21 213 941400 21356 62526053
Blood potassium increased 20.27 11.21 383 941230 17926 62529483
Lymphoproliferative disorder 20.27 11.21 11 941602 3179 62544230
Embolic stroke 20.26 11.21 110 941503 3666 62543743
Drug specific antibody 20.21 11.21 5 941608 2350 62545059
Osteonecrosis of jaw 20.13 11.21 383 941230 34740 62512669
Carotid artery disease 20.13 11.21 62 941551 1587 62545822
Inappropriate schedule of product administration 20.09 11.21 1300 940313 102665 62444744
Mitral valve stenosis 20.07 11.21 50 941563 1127 62546282
Nail disorder 20.07 11.21 112 941501 12903 62534506
Crystal urine present 20.02 11.21 62 941551 1592 62545817
Ventricular extrasystoles 19.99 11.21 263 941350 11424 62535985
Blood creatine increased 19.97 11.21 147 941466 5454 62541955
Skin necrosis 19.94 11.21 123 941490 13827 62533582
Hypovolaemia 19.88 11.21 244 941369 10429 62536980
Product dose omission in error 19.82 11.21 53 941560 7559 62539850
Sarcoidosis 19.77 11.21 48 941565 7074 62540335
Premature baby 19.71 11.21 424 941189 20311 62527098
Blood pressure inadequately controlled 19.71 11.21 134 941479 4844 62542565
Cardiac valve disease 19.63 11.21 119 941494 4133 62543276
Basal ganglia haemorrhage 19.61 11.21 35 941578 619 62546790
Device leakage 19.56 11.21 48 941565 7048 62540361
Sickle cell anaemia with crisis 19.54 11.21 37 941576 5966 62541443
PCO2 decreased 19.54 11.21 53 941560 1260 62546149
Acne 19.54 11.21 236 941377 23057 62524352
Foetal exposure timing unspecified 19.49 11.21 22 941591 248 62547161
Femoral artery aneurysm 19.48 11.21 7 941606 4 62547405
Aortic arteriosclerosis 19.39 11.21 158 941455 6051 62541358
Anaphylactic shock 19.24 11.21 241 941372 23392 62524017
Oral allergy syndrome 19.22 11.21 12 941601 53 62547356
Gangrene 19.22 11.21 156 941457 5967 62541442
Traumatic liver injury 19.05 11.21 23 941590 280 62547129
Breast cancer 18.99 11.21 559 941054 47824 62499585
Vascular device infection 18.97 11.21 51 941562 7261 62540148
Product substitution issue 18.94 11.21 149 941464 15847 62531562
Metastases to peritoneum 18.94 11.21 14 941599 3428 62543981
Splenic rupture 18.91 11.21 53 941560 1285 62546124
Dermatitis atopic 18.90 11.21 77 941536 9647 62537762
Mouth haemorrhage 18.76 11.21 168 941445 6615 62540794
Petechiae 18.73 11.21 300 941313 13597 62533812
Irritability 18.67 11.21 344 941269 31350 62516059
Injection site induration 18.60 11.21 72 941541 9154 62538255
Exposure via ingestion 18.59 11.21 89 941524 2820 62544589
Gait inability 18.57 11.21 621 940992 52338 62495071
Diabetic retinopathy 18.51 11.21 76 941537 2251 62545158
Brain contusion 18.44 11.21 32 941581 553 62546856
Asthma-chronic obstructive pulmonary disease overlap syndrome 18.43 11.21 4 941609 2057 62545352
Ageusia 18.37 11.21 296 941317 13432 62533977
Device inappropriate shock delivery 18.34 11.21 7 941606 6 62547403
Bronchopulmonary aspergillosis 18.32 11.21 66 941547 8569 62538840
Drug eruption 18.32 11.21 307 941306 28387 62519022
Arterial injury 18.27 11.21 22 941591 267 62547142
Extremity contracture 18.26 11.21 51 941562 1234 62546175
Myositis 18.21 11.21 214 941399 9052 62538357
Exostosis 18.20 11.21 173 941440 17689 62529720
Headache 18.07 11.21 8818 932795 624423 61922986
Menstruation irregular 18.06 11.21 49 941564 6955 62540454
Brain stem haemorrhage 18.05 11.21 37 941576 729 62546680
Injection site mass 18.04 11.21 183 941430 18473 62528936
Nodule 18.03 11.21 212 941401 20814 62526595
Hypersensitivity myocarditis 18.03 11.21 19 941594 197 62547212
Endometriosis 18.02 11.21 32 941581 5288 62542121
Status epilepticus 17.99 11.21 142 941471 15091 62532318
Disorientation 17.98 11.21 736 940877 38716 62508693
Electrocardiogram T wave abnormal 17.97 11.21 78 941535 2369 62545040
Prescribed underdose 17.87 11.21 321 941292 29368 62518041
Injection site bruising 17.78 11.21 479 941134 41431 62505978
Lupus vasculitis 17.77 11.21 31 941582 538 62546871
Hyperglycaemia 17.72 11.21 775 940838 41092 62506317
Mania 17.70 11.21 109 941504 12258 62535151
Implant site pain 17.69 11.21 7 941606 2433 62544976
Diabetes mellitus inadequate control 17.64 11.21 319 941294 14807 62532602
Angioplasty 17.62 11.21 53 941560 1339 62546070
Subchorionic haematoma 17.60 11.21 15 941598 116 62547293
Bradyarrhythmia 17.56 11.21 70 941543 2045 62545364
Atrioventricular block first degree 17.55 11.21 175 941438 7098 62540311
Mediastinal haematoma 17.54 11.21 13 941600 80 62547329
Small intestinal ulcer haemorrhage 17.51 11.21 12 941601 64 62547345
Percutaneous coronary intervention 17.48 11.21 20 941593 229 62547180
Granuloma 17.48 11.21 37 941576 5724 62541685
Product label confusion 17.43 11.21 3 941610 1819 62545590
Gastrointestinal angiodysplasia 17.42 11.21 28 941585 453 62546956
Pregnancy with implant contraceptive 17.41 11.21 9 941604 2674 62544735
Device related infection 17.41 11.21 243 941370 23149 62524260
Platelet dysfunction 17.39 11.21 14 941599 99 62547310
Wound haematoma 17.37 11.21 12 941601 65 62547344
Pulmonary tuberculosis 17.35 11.21 25 941588 4492 62542917
Hepatotoxicity 17.34 11.21 693 940920 36348 62511061
Oral herpes 17.29 11.21 277 941336 25797 62521612
Extremity necrosis 17.29 11.21 58 941555 1555 62545854
Ejection fraction 17.28 11.21 7 941606 2399 62545010
Shoulder arthroplasty 17.22 11.21 110 941503 3892 62543517
Insurance issue 17.19 11.21 41 941572 6080 62541329
Depression 17.18 11.21 2604 939009 193888 62353521
Seronegative arthritis 17.18 11.21 20 941593 3939 62543470
Ductus arteriosus premature closure 17.16 11.21 23 941590 313 62547096
Bursitis 17.14 11.21 418 941195 36623 62510786
Sleep disorder due to a general medical condition 17.14 11.21 108 941505 12080 62535329
Left-to-right cardiac shunt 17.11 11.21 15 941598 121 62547288
Blood sodium decreased 17.06 11.21 476 941137 23776 62523633
Renal haemorrhage 17.05 11.21 41 941572 903 62546506
Vascular graft occlusion 16.97 11.21 19 941594 212 62547197
Nonreassuring foetal heart rate pattern 16.90 11.21 11 941602 53 62547356
Dry gangrene 16.89 11.21 33 941580 627 62546782
Liver transplant 16.81 11.21 73 941540 2218 62545191
Blood alkaline phosphatase increased 16.80 11.21 789 940824 42178 62505231
Incorrect dose administered by device 16.77 11.21 24 941589 4324 62543085
Ultrasound Doppler abnormal 16.74 11.21 16 941597 146 62547263
Thrombotic stroke 16.72 11.21 29 941584 501 62546908
Hiatus hernia 16.67 11.21 429 941184 21165 62526244
Non-cardiac chest pain 16.66 11.21 154 941459 6118 62541291
Peripheral artery thrombosis 16.63 11.21 65 941548 1881 62545528
Bundle branch block right 16.60 11.21 129 941484 4869 62542540
Finger deformity 16.56 11.21 59 941554 7686 62539723
Platelet aggregation inhibition 16.56 11.21 15 941598 127 62547282
Catheterisation cardiac 16.52 11.21 121 941492 4482 62542927
Cardio-respiratory arrest 16.52 11.21 1066 940547 58893 62488516
Musculoskeletal deformity 16.49 11.21 4 941609 1905 62545504
Blood pH decreased 16.42 11.21 79 941534 2508 62544901
Hypertensive heart disease 16.39 11.21 76 941537 2376 62545033
Feeding disorder 16.37 11.21 284 941329 13078 62534331
Rash papulosquamous 16.36 11.21 13 941600 90 62547319
Infusion site swelling 16.36 11.21 219 941394 9551 62537858
Atrial flutter 16.34 11.21 219 941394 9553 62537856
Essential thrombocythaemia 16.33 11.21 16 941597 151 62547258
Anosognosia 16.33 11.21 14 941599 3182 62544227
Vascular dementia 16.30 11.21 30 941583 544 62546865
Acute pulmonary oedema 16.29 11.21 189 941424 7969 62539440
Genital haemorrhage 16.25 11.21 55 941558 7277 62540132
Contusion 16.22 11.21 2499 939114 147545 62399864
Maternal exposure before pregnancy 16.20 11.21 58 941555 7545 62539864
Haemoglobin increased 16.18 11.21 101 941512 3545 62543864
Tooth disorder 16.16 11.21 539 941074 27618 62519791
Chronic kidney disease 16.15 11.21 826 940787 44572 62502837
Peptic ulcer 16.14 11.21 120 941493 4467 62542942
Cystitis 16.13 11.21 983 940630 54008 62493401
Respiratory alkalosis 16.09 11.21 81 941532 2620 62544789
Thrombocytosis 16.04 11.21 144 941469 5674 62541735
Periorbital haematoma 16.01 11.21 36 941577 758 62546651
Tachyarrhythmia 15.99 11.21 117 941496 4333 62543076
Tuberculosis 15.94 11.21 99 941514 11112 62536297
Urinary incontinence 15.94 11.21 603 941010 31411 62515998
Hepatitis acute 15.92 11.21 206 941407 8914 62538495
Virologic failure 15.89 11.21 4 941609 1858 62545551
Full blood count increased 15.89 11.21 43 941570 1021 62546388
Ventricular internal diameter abnormal 15.86 11.21 9 941604 32 62547377
Electrocardiogram T wave inversion 15.80 11.21 97 941516 3384 62544025
Uveitis 15.78 11.21 115 941498 12438 62534971
Dermatitis exfoliative generalised 15.71 11.21 20 941593 3787 62543622
Acute lymphocytic leukaemia recurrent 15.66 11.21 7 941606 2262 62545147
Rectourethral fistula 15.66 11.21 9 941604 33 62547376
Eye disorder 15.61 11.21 444 941169 22241 62525168
Blood urine present 15.59 11.21 312 941301 14757 62532652
Breast cancer stage IV 15.59 11.21 5 941608 1981 62545428
Pre-existing condition improved 15.58 11.21 66 941547 8178 62539231
Skin haemorrhage 15.57 11.21 223 941390 9871 62537538
Brain stem infarction 15.55 11.21 36 941577 773 62546636
Pelvic pain 15.51 11.21 127 941486 13392 62534017
Carotid artery occlusion 15.51 11.21 121 941492 4573 62542836
Road traffic accident 15.45 11.21 419 941194 36213 62511196
Platelet aggregation increased 15.43 11.21 7 941606 13 62547396
Joint effusion 15.42 11.21 170 941443 16890 62530519
International normalised ratio decreased 15.41 11.21 117 941496 4384 62543025
Mood altered 15.36 11.21 142 941471 14601 62532808
Juvenile idiopathic arthritis 15.31 11.21 16 941597 3310 62544099
Poisoning 15.31 11.21 287 941326 13413 62533996
Reye's syndrome 15.29 11.21 6 941607 6 62547403
Orthopnoea 15.28 11.21 151 941462 6110 62541299
Androgenetic alopecia 15.27 11.21 15 941598 142 62547267
Metastasis 15.25 11.21 34 941579 5163 62542246
Platelet function test abnormal 15.23 11.21 12 941601 82 62547327
Duodenitis 15.17 11.21 102 941511 3673 62543736
Pelvic haematoma 15.05 11.21 30 941583 579 62546830
Osmolar gap 15.01 11.21 13 941600 103 62547306
Chromaturia 14.99 11.21 339 941274 16378 62531031
Faecaloma 14.99 11.21 182 941431 7759 62539650
Tuberculin test positive 14.95 11.21 18 941595 3493 62543916
Choroidal haemorrhage 14.93 11.21 10 941603 51 62547358
Bronchiectasis 14.93 11.21 160 941453 15982 62531427
Mucosal erosion 14.93 11.21 53 941560 1463 62545946
Transplant rejection 14.92 11.21 96 941517 10684 62536725
Platelet count increased 14.91 11.21 356 941257 17355 62530054
Red blood cell sedimentation rate abnormal 14.90 11.21 205 941408 19577 62527832
Subclavian steal syndrome 14.90 11.21 9 941604 37 62547372
Vessel puncture site haematoma 14.88 11.21 14 941599 125 62547284
Cerebral thrombosis 14.88 11.21 57 941556 1634 62545775
Cerebral amyloid angiopathy 14.88 11.21 15 941598 147 62547262
Capillary fragility test 14.84 11.21 8 941605 25 62547384
Aortic aneurysm rupture 14.84 11.21 28 941585 518 62546891
Periorbital oedema 14.81 11.21 139 941474 5545 62541864
Infusion site pain 14.79 11.21 341 941272 16528 62530881
Electrocardiogram PR prolongation 14.79 11.21 33 941580 691 62546718
Oesophageal ulcer haemorrhage 14.76 11.21 23 941590 362 62547047
Aortic valve sclerosis 14.63 11.21 45 941568 1151 62546258
Hereditary angioedema 14.62 11.21 60 941553 7502 62539907
Vascular occlusion 14.61 11.21 39 941574 918 62546491
Rectal polyp 14.59 11.21 46 941567 1193 62546216
Sensory loss 14.55 11.21 223 941390 10015 62537394
Gastrointestinal ischaemia 14.47 11.21 16 941597 176 62547233
Dysmorphism 14.47 11.21 8 941605 2288 62545121
Gastritis haemorrhagic 14.36 11.21 53 941560 1492 62545917
Body tinea 14.35 11.21 5 941608 1880 62545529
Aortic aneurysm 14.35 11.21 102 941511 3742 62543667
Palpitations 14.34 11.21 1896 939717 110874 62436535
Diastolic dysfunction 14.33 11.21 153 941460 6318 62541091
Lip swelling 14.27 11.21 580 941033 30483 62516926
Gastrointestinal ulcer 14.23 11.21 67 941546 2108 62545301
Procedural haemorrhage 14.22 11.21 78 941535 2610 62544799
Onychomadesis 14.22 11.21 42 941571 5798 62541611
Spinal subdural haematoma 14.22 11.21 14 941599 133 62547276
Gestational diabetes 14.20 11.21 70 941543 8326 62539083
Cytomegalovirus infection reactivation 14.20 11.21 23 941590 3940 62543469
Laryngitis 14.20 11.21 172 941441 16795 62530614
Disease recurrence 14.18 11.21 312 941301 27718 62519691
Immune-mediated myositis 14.14 11.21 48 941565 1295 62546114
Sinus arrhythmia 14.08 11.21 51 941562 1422 62545987
Electrocardiogram ST-T change 14.07 11.21 41 941572 1017 62546392
Sudden cardiac death 14.06 11.21 66 941547 2074 62545335
Haemolysis 14.06 11.21 158 941455 6610 62540799
Lichen planopilaris 14.04 11.21 9 941604 42 62547367
Tachypnoea 14.03 11.21 346 941267 16956 62530453
Wound infection 14.02 11.21 228 941385 21182 62526227
Hypoaesthesia 14.01 11.21 2238 939375 166155 62381254
Haemorrhoidal haemorrhage 13.97 11.21 110 941503 4169 62543240
Vertebral artery stenosis 13.95 11.21 10 941603 58 62547351
Low density lipoprotein increased 13.94 11.21 150 941463 6207 62541202
Nodal rhythm 13.92 11.21 57 941556 1686 62545723
Bezoar 13.89 11.21 52 941561 1474 62545935
Tongue haematoma 13.86 11.21 11 941602 76 62547333
Coronary artery dilatation 13.82 11.21 5 941608 3 62547406
Lip haematoma 13.82 11.21 5 941608 3 62547406
Muscle spasms 13.81 11.21 2573 939040 153577 62393832
Cerebellar infarction 13.80 11.21 63 941550 1956 62545453
Haemorrhagic erosive gastritis 13.79 11.21 25 941588 448 62546961
Vitamin K deficiency 13.78 11.21 24 941589 416 62546993
Diffuse large B-cell lymphoma 13.78 11.21 52 941561 6660 62540749
Placental infarction 13.76 11.21 20 941593 295 62547114
Vascular stent occlusion 13.73 11.21 9 941604 44 62547365
Muscular weakness 13.71 11.21 2042 939571 120311 62427098
Pulmonary alveolar haemorrhage 13.63 11.21 117 941496 4551 62542858
Brown-Sequard syndrome 13.62 11.21 6 941607 10 62547399
Idiopathic intracranial hypertension 13.61 11.21 14 941599 2917 62544492
Ventricular dysfunction 13.60 11.21 80 941533 2748 62544661
Hallucination, auditory 13.59 11.21 123 941490 12701 62534708
Cerebral artery stenosis 13.52 11.21 25 941588 455 62546954
Gingival bleeding 13.49 11.21 262 941351 12325 62535084
Varicella zoster virus infection 13.47 11.21 12 941601 2677 62544732
Coeliac disease 13.44 11.21 123 941490 12674 62534735
Cerebral hyperperfusion syndrome 13.43 11.21 7 941606 20 62547389
Ectopic pregnancy 13.42 11.21 11 941602 2556 62544853
Cerebrovascular stenosis 13.41 11.21 8 941605 32 62547377
Catatonia 13.38 11.21 29 941584 4448 62542961
Analgesic drug level above therapeutic 13.36 11.21 15 941598 168 62547241
Large intestine polyp 13.31 11.21 182 941431 7975 62539434
Oxygen saturation decreased 13.30 11.21 1505 940108 87080 62460329
Thrombotic thrombocytopenic purpura 13.29 11.21 100 941513 3736 62543673
Leukocytosis 13.27 11.21 490 941123 25445 62521964
Oliguria 13.23 11.21 199 941414 8902 62538507
Coronary artery insufficiency 13.22 11.21 11 941602 82 62547327
Frequent bowel movements 13.21 11.21 251 941362 22771 62524638
Erythema 13.20 11.21 2349 939264 173402 62374007
Cerebral artery occlusion 13.19 11.21 36 941577 859 62546550
Retinal artery occlusion 13.16 11.21 54 941559 1599 62545810
Hypocapnia 13.13 11.21 22 941591 369 62547040
Hypogammaglobulinaemia 13.08 11.21 58 941555 7097 62540312
Cardiac failure chronic 13.04 11.21 111 941502 4307 62543102
Placental insufficiency 13.03 11.21 49 941564 1392 62546017
Ocular retrobulbar haemorrhage 13.03 11.21 12 941601 104 62547305
Hypoacusis 13.02 11.21 459 941154 23692 62523717
Drug reaction with eosinophilia and systemic symptoms 13.01 11.21 392 941221 33444 62513965
Capillary fragility increased 12.90 11.21 4 941609 0 62547409
Myocardial haemorrhage 12.90 11.21 4 941609 0 62547409
Subcapsular hepatic haematoma 12.90 11.21 4 941609 0 62547409
Cardiac pacemaker insertion 12.89 11.21 105 941508 4021 62543388
Leukocyturia 12.88 11.21 49 941564 1400 62546009
Coronary artery reocclusion 12.87 11.21 8 941605 35 62547374
Paronychia 12.85 11.21 41 941572 5524 62541885
Dermatitis acneiform 12.85 11.21 35 941578 4961 62542448
Skin discolouration 12.79 11.21 685 940928 37143 62510266
Alanine aminotransferase abnormal 12.79 11.21 30 941583 4474 62542935
Otitis media bacterial 12.74 11.21 5 941608 5 62547404
Otitis media staphylococcal 12.74 11.21 5 941608 5 62547404
Angiogram 12.73 11.21 10 941603 68 62547341
Anticoagulation drug level below therapeutic 12.72 11.21 31 941582 689 62546720
Hyperhidrosis 12.71 11.21 1805 939808 106031 62441378
Blood pressure abnormal 12.65 11.21 305 941308 14893 62532516
Mitral valve calcification 12.63 11.21 38 941575 960 62546449
Dysphoria 12.61 11.21 35 941578 4931 62542478
Blepharospasm 12.61 11.21 46 941567 5950 62541459
Urine albumin/creatinine ratio increased 12.60 11.21 19 941594 290 62547119
Cardiac operation 12.60 11.21 88 941525 3210 62544199
Haemorrhagic cerebral infarction 12.58 11.21 29 941584 621 62546788
Nervousness 12.57 11.21 571 941042 30408 62517001
Post procedural pulmonary embolism 12.55 11.21 18 941595 262 62547147
Cholecystitis acute 12.55 11.21 182 941431 8078 62539331
Bipolar disorder 12.55 11.21 68 941545 7892 62539517
Urinary straining 12.54 11.21 8 941605 37 62547372
Infusion site erythema 12.48 11.21 243 941370 11436 62535973
Giant cell arteritis 12.47 11.21 67 941546 2224 62545185
Menstruation delayed 12.47 11.21 5 941608 1724 62545685
Peripheral artery occlusion 12.46 11.21 45 941568 1253 62546156
Brain death 12.45 11.21 90 941523 3320 62544089
Cardiac murmur 12.40 11.21 293 941320 14259 62533150
Pruritus allergic 12.39 11.21 4 941609 1578 62545831
Basal cell carcinoma 12.38 11.21 318 941295 27673 62519736
Brain compression 12.37 11.21 22 941591 388 62547021
Onychomycosis 12.37 11.21 68 941545 7864 62539545
Facial paralysis 12.36 11.21 284 941329 13757 62533652
Intestinal ischaemia 12.34 11.21 167 941446 7301 62540108
Nail ridging 12.33 11.21 22 941591 389 62547020
Adrenal insufficiency 12.33 11.21 189 941424 17726 62529683
Base excess 12.29 11.21 10 941603 72 62547337
Blood calcium increased 12.28 11.21 201 941412 9149 62538260
Colorectal cancer 12.28 11.21 22 941591 3623 62543786
Interventricular septum rupture 12.28 11.21 5 941608 6 62547403
Cardiotoxicity 12.27 11.21 74 941539 8364 62539045
Infarction 12.25 11.21 74 941539 2567 62544842
Administration site pain 12.24 11.21 34 941579 820 62546589
Carotid bruit 12.19 11.21 31 941582 708 62546701
Product adhesion issue 12.18 11.21 33 941580 4686 62542723
Tendonitis 12.15 11.21 211 941402 19404 62528005
Psychotic symptom 12.13 11.21 4 941609 1557 62545852
Multiple allergies 12.10 11.21 279 941334 13523 62533886
Infusion site nodule 12.08 11.21 49 941564 1443 62545966
Cystitis haemorrhagic 12.08 11.21 27 941586 4096 62543313
Intestinal haemorrhage 12.07 11.21 98 941515 3749 62543660
Hypotensive transfusion reaction 12.07 11.21 8 941605 40 62547369
Arterial restenosis 12.06 11.21 6 941607 15 62547394
Dermatitis exfoliative 12.06 11.21 129 941484 5330 62542079
Obstructive shock 11.92 11.21 8 941605 41 62547368
Septic shock 11.89 11.21 839 940774 65790 62481619
Nasal disorder 11.88 11.21 78 941535 2786 62544623
Vitreous haemorrhage 11.88 11.21 61 941552 1989 62545420
Tongue oedema 11.88 11.21 112 941501 4474 62542935
Polycythaemia vera 11.87 11.21 14 941599 166 62547243
Iliac artery stenosis 11.87 11.21 10 941603 76 62547333
Sensitivity to weather change 11.87 11.21 61 941552 7176 62540233
Puncture site haematoma 11.86 11.21 5 941608 7 62547402
Viral mutation identified 11.86 11.21 6 941607 1804 62545605
Injection site discolouration 11.85 11.21 68 941545 7780 62539629
Epilepsy 11.83 11.21 308 941305 26757 62520652
Increased tendency to bruise 11.77 11.21 221 941392 10331 62537078
Rhinitis allergic 11.77 11.21 114 941499 11613 62535796
Coagulation time abnormal 11.77 11.21 10 941603 77 62547332
Hand-eye coordination impaired 11.73 11.21 7 941606 28 62547381
Leriche syndrome 11.73 11.21 7 941606 28 62547381
Myocardial rupture 11.71 11.21 9 941604 59 62547350
Therapy cessation 11.68 11.21 353 941260 30104 62517305
Artery dissection 11.67 11.21 10 941603 78 62547331
Tongue haemorrhage 11.66 11.21 22 941591 407 62547002
Live birth 11.65 11.21 290 941323 25340 62522069
Troponin T increased 11.64 11.21 43 941570 1211 62546198
Haptoglobin increased 11.63 11.21 8 941605 43 62547366
Skin laceration 11.61 11.21 429 941184 22279 62525130
Aortic valve disease 11.59 11.21 41 941572 1130 62546279
Injury associated with device 11.58 11.21 23 941590 3643 62543766
Mallory-Weiss syndrome 11.57 11.21 49 941564 1472 62545937
Spinal cord haematoma 11.56 11.21 14 941599 171 62547238
Anti A antibody positive 11.55 11.21 7 941606 29 62547380
Umbilical haemorrhage 11.55 11.21 6 941607 17 62547392
High density lipoprotein decreased 11.50 11.21 63 941550 2107 62545302
Large intestinal ulcer 11.50 11.21 89 941524 3355 62544054
Rheumatoid lung 11.44 11.21 25 941588 3823 62543586
Pneumonitis 11.43 11.21 417 941196 34805 62512604
Lymphopenia 11.40 11.21 197 941416 18130 62529279
Ocular icterus 11.40 11.21 93 941520 3563 62543846
Colitis ulcerative 11.38 11.21 297 941316 25794 62521615
Dissociation 11.37 11.21 16 941597 2903 62544506
Thinking abnormal 11.31 11.21 102 941511 10541 62536868
Eructation 11.27 11.21 180 941433 8153 62539256
Microalbuminuria 11.26 11.21 21 941592 385 62547024
Left atrial dilatation 11.22 11.21 56 941557 1805 62545604
Vitello-intestinal duct remnant 11.21 11.21 8 941605 46 62547363

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Myocardial infarction 1515.34 13.72 5878 746691 115207 34089155
Gastrointestinal haemorrhage 1441.44 13.72 4685 747884 83792 34120570
Drug ineffective 1197.74 13.72 5420 747149 451331 33753031
Coronary artery disease 1164 13.72 2946 749623 45359 34159003
Off label use 933.83 13.72 5267 747302 414257 33790105
Acute myocardial infarction 924.55 13.72 2900 749669 50819 34153543
Labelled drug-drug interaction medication error 808.86 13.72 1279 751290 13660 34190702
Drug abuse 613.28 13.72 738 751831 98358 34106004
Angina pectoris 549.34 13.72 1704 750865 29659 34174703
Upper gastrointestinal haemorrhage 544.64 13.72 1488 751081 24030 34180332
Cardiac failure congestive 524.53 13.72 3327 749242 79943 34124419
Melaena 521.67 13.72 1813 750756 33567 34170795
Gastric haemorrhage 480.58 13.72 823 751746 9438 34194924
Vascular stent thrombosis 479.13 13.72 441 752128 2494 34201868
Angina unstable 443.26 13.72 854 751715 10799 34193563
Cerebrovascular accident 440.25 13.72 3231 749338 81580 34122782
Febrile neutropenia 437.03 13.72 1497 751072 135352 34069010
Product use in unapproved indication 398.12 13.72 1252 751317 116247 34088115
Chest pain 333.52 13.72 4182 748387 122580 34081782
Treatment failure 325.08 13.72 315 752254 46382 34157980
Coronary artery bypass 312.58 13.72 453 752116 4449 34199913
Lower gastrointestinal haemorrhage 307.35 13.72 649 751920 8803 34195559
Haemorrhage 290.21 13.72 1998 750571 49372 34154990
Disease progression 287.95 13.72 1271 751298 106806 34097556
Thrombosis in device 286.69 13.72 356 752213 2969 34201393
Coronary arterial stent insertion 286.08 13.72 397 752172 3732 34200630
Haematuria 285.63 13.72 1952 750617 48114 34156248
Cerebral haemorrhage 283.82 13.72 1494 751075 33443 34170919
Syncope 276.07 13.72 3098 749471 88353 34116009
Death 273.19 13.72 6509 746060 391540 33812822
Neutropenia 252.97 13.72 2158 750411 154620 34049742
Haematemesis 251.78 13.72 1223 751346 26488 34177874
Coronary artery stenosis 244.53 13.72 599 751970 9017 34195345
Malignant neoplasm progression 236.56 13.72 1032 751537 87014 34117348
Coronary artery occlusion 235.60 13.72 641 751928 10321 34194041
Subdural haematoma 222.57 13.72 951 751618 19470 34184892
Haemorrhage intracranial 211.02 13.72 789 751780 15157 34189205
Gastric ulcer 199.36 13.72 765 751804 14885 34189477
Rectal haemorrhage 197.11 13.72 1513 751056 38736 34165626
Haematoma 186.47 13.72 1063 751506 24542 34179820
Transient ischaemic attack 185.35 13.72 1122 751447 26491 34177871
Myocardial ischaemia 184.58 13.72 804 751765 16604 34187758
Dizziness 179.83 13.72 6059 746510 212462 33991900
Mucosal inflammation 171.11 13.72 359 752210 38263 34166099
Drug dependence 167.76 13.72 164 752405 24053 34180309
Aspirin-exacerbated respiratory disease 166.87 13.72 104 752465 283 34204079
Therapeutic product effect incomplete 163.71 13.72 549 752020 49992 34154370
Epistaxis 160.37 13.72 1939 750630 56312 34148050
Acute coronary syndrome 157.93 13.72 644 751925 12901 34191461
Blood loss anaemia 154.48 13.72 457 752112 7737 34196625
Condition aggravated 151.28 13.72 3073 749496 189123 34015239
Faeces discoloured 150.06 13.72 677 751892 14201 34190161
Hospitalisation 149.12 13.72 673 751896 56229 34148133
Myelosuppression 148.48 13.72 118 752451 19147 34185215
Pyrexia 148.17 13.72 5768 746801 327245 33877117
Rhabdomyolysis 147.47 13.72 2172 750397 65991 34138371
Atrial fibrillation 143.41 13.72 3549 749020 118844 34085518
Bone marrow failure 139.85 13.72 260 752309 28993 34175369
Drug resistance 137.18 13.72 216 752353 25711 34178651
Haematochezia 136.93 13.72 1569 751000 44965 34159397
Sepsis 136.80 13.72 2644 749925 163917 34040445
Duodenal ulcer 134.85 13.72 509 752060 9823 34194539
Post procedural haemorrhage 134.68 13.72 439 752130 7850 34196512
Vascular stent stenosis 134.62 13.72 146 752423 1035 34203327
Cytomegalovirus infection 128.77 13.72 228 752341 25907 34178455
Drug ineffective for unapproved indication 126.01 13.72 197 752372 23518 34180844
C-reactive protein abnormal 122.77 13.72 20 752549 8690 34195672
Gastritis erosive 122.63 13.72 342 752227 5590 34198772
Pancytopenia 118.61 13.72 1393 751176 93764 34110598
Pathogen resistance 116.63 13.72 30 752539 9452 34194910
Graft versus host disease 116.30 13.72 41 752528 10528 34193834
Anaemia 116.25 13.72 6138 746431 227197 33977165
Foetal exposure during pregnancy 113.95 13.72 428 752141 37673 34166689
Haemorrhagic stroke 112.32 13.72 353 752216 6186 34198176
Plasma cell myeloma 112.07 13.72 1391 751178 40646 34163716
Injection site pain 111.62 13.72 446 752123 38559 34165803
Drug intolerance 111.32 13.72 787 751782 58783 34145579
Immune reconstitution inflammatory syndrome 111.07 13.72 26 752543 8733 34195629
Gastric ulcer haemorrhage 109.93 13.72 312 752257 5154 34199208
Septic shock 109.82 13.72 1002 751567 70832 34133530
Neurotoxicity 108.25 13.72 137 752432 17873 34186489
Coronary artery restenosis 107.82 13.72 122 752447 912 34203450
Therapy partial responder 106.33 13.72 37 752532 9579 34194783
Psychotic disorder 105.20 13.72 231 752338 24221 34180141
Subarachnoid haemorrhage 105.11 13.72 544 752025 12091 34192271
Hypotension 104.89 13.72 5803 746766 215846 33988516
Coronary artery thrombosis 103.50 13.72 175 752394 1984 34202378
Product use issue 103.18 13.72 867 751702 62349 34142013
Seizure 102.19 13.72 1614 750955 103243 34101119
Haemoglobin decreased 101.72 13.72 3359 749210 117413 34086949
Ascites 100.94 13.72 588 751981 45983 34158379
Product dose omission issue 99.83 13.72 1895 750674 117816 34086546
Haemorrhagic arteriovenous malformation 99.83 13.72 76 752493 314 34204048
Akathisia 99.08 13.72 26 752543 8083 34196279
Product administration error 99.01 13.72 647 751922 15697 34188665
Bronchopulmonary aspergillosis 98.41 13.72 102 752467 14557 34189805
Mitral valve incompetence 97.62 13.72 603 751966 14340 34190022
Vascular graft 97.54 13.72 141 752428 1381 34202981
Bradycardia 97.13 13.72 2216 750353 73202 34131160
Shock haemorrhagic 96.65 13.72 492 752077 10862 34193500
COVID-19 95.94 13.72 1137 751432 76413 34127949
Fall 93.07 13.72 5297 747272 197588 34006774
Dyspnoea 91.82 13.72 9355 743214 367427 33836935
Pneumocystis jirovecii pneumonia 91.73 13.72 178 752391 19532 34184830
Small intestinal haemorrhage 90.92 13.72 163 752406 1943 34202419
Carotid artery stenosis 90.90 13.72 276 752293 4743 34199619
Leukopenia 90.85 13.72 889 751680 61967 34142395
Suicidal ideation 90.19 13.72 505 752064 39883 34164479
Duodenal ulcer haemorrhage 89.23 13.72 274 752295 4739 34199623
Multiple-drug resistance 89.19 13.72 6 752563 5233 34199129
Acute graft versus host disease 87.17 13.72 17 752552 6486 34197876
Haematotoxicity 86.44 13.72 34 752535 8160 34196202
Venoocclusive liver disease 85.79 13.72 32 752537 7934 34196428
Stomatitis 85.75 13.72 549 752020 41965 34162397
Retroperitoneal haematoma 84.88 13.72 182 752387 2496 34201866
Aspergillus infection 84.85 13.72 83 752486 12171 34192191
Neuroleptic malignant syndrome 83.43 13.72 162 752407 17772 34186590
Status epilepticus 83.30 13.72 89 752480 12525 34191837
Infective pulmonary exacerbation of cystic fibrosis 82.73 13.72 22 752547 6779 34197583
Angioedema 81.99 13.72 1194 751375 36180 34168182
Ischaemic cardiomyopathy 81.11 13.72 312 752257 6077 34198285
Multiple organ dysfunction syndrome 80.59 13.72 1161 751408 75405 34128957
Diverticulum intestinal haemorrhagic 79.70 13.72 172 752397 2370 34201992
Thrombosis 78.74 13.72 1525 751044 48933 34155429
Therapeutic response decreased 76.58 13.72 347 752222 28966 34175396
Infection 74.58 13.72 1443 751126 89472 34114890
Ischaemic stroke 74.25 13.72 658 751911 17592 34186770
Neoplasm progression 74.13 13.72 255 752314 23045 34181317
Post transplant lymphoproliferative disorder 74.13 13.72 24 752545 6504 34197858
Posterior reversible encephalopathy syndrome 72.97 13.72 64 752505 9890 34194472
Iron deficiency anaemia 72.69 13.72 425 752144 9904 34194458
Intentional self-injury 72.58 13.72 115 752454 13656 34190706
Intraventricular haemorrhage 71.44 13.72 202 752367 3329 34201033
International normalised ratio increased 71.36 13.72 1423 751146 45904 34158458
Psoriatic arthropathy 71.20 13.72 205 752364 19593 34184769
Acute graft versus host disease in skin 70.98 13.72 13 752556 5188 34199174
Haemophagocytic lymphohistiocytosis 69.65 13.72 107 752462 12866 34191496
Vascular pseudoaneurysm 69.52 13.72 148 752421 2019 34202343
Cerebral infarction 69.13 13.72 899 751670 26556 34177806
Febrile bone marrow aplasia 68.82 13.72 46 752523 8163 34196199
Intercepted product preparation error 68.47 13.72 5 752564 4073 34200289
Intentional product use issue 67.96 13.72 893 751676 58923 34145439
Cytokine release syndrome 67.73 13.72 258 752311 22619 34181743
Presyncope 66.46 13.72 665 751904 18394 34185968
Myalgia 66.13 13.72 2321 750248 81789 34122573
Subdural haemorrhage 65.99 13.72 184 752385 3007 34201355
Haemorrhagic transformation stroke 65.91 13.72 118 752451 1405 34202957
Post procedural haematoma 64.46 13.72 117 752452 1409 34202953
Pain 64.17 13.72 3678 748891 200997 34003365
Enthesopathy 64.11 13.72 11 752558 4602 34199760
Occult blood positive 63.62 13.72 212 752357 3836 34200526
Graft versus host disease in gastrointestinal tract 63.35 13.72 4 752565 3679 34200683
Sedation 62.78 13.72 236 752333 20770 34183592
Dyspnoea exertional 62.50 13.72 1293 751276 41986 34162376
Pericardial haemorrhage 62.28 13.72 179 752390 2979 34201383
Virologic failure 62.27 13.72 3 752566 3477 34200885
Synovitis 62.07 13.72 131 752438 13935 34190427
BK virus infection 61.87 13.72 23 752546 5715 34198647
Ventricular tachycardia 61.44 13.72 857 751712 25722 34178640
Arterial haemorrhage 61.39 13.72 85 752484 797 34203565
Gastrointestinal vascular malformation haemorrhagic 61.11 13.72 72 752497 565 34203797
Appendicolith 61.02 13.72 57 752512 8544 34195818
Serotonin syndrome 60.84 13.72 222 752347 19711 34184651
Wrong technique in product usage process 60.77 13.72 489 752080 35497 34168865
Internal haemorrhage 59.81 13.72 241 752328 4800 34199562
Asthenia 59.49 13.72 6089 746480 239162 33965200
Gastritis 59.24 13.72 726 751843 21147 34183215
Cytomegalovirus viraemia 59.17 13.72 44 752525 7386 34196976
Progressive multifocal leukoencephalopathy 58.96 13.72 74 752495 9690 34194672
Lymphopenia 58.85 13.72 169 752400 16166 34188196
Thrombotic microangiopathy 58.69 13.72 86 752483 10544 34193818
Cardiac failure 57.99 13.72 2460 750109 88788 34115574
Graft versus host disease in skin 57.65 13.72 8 752561 3917 34200445
Arteriosclerosis 57.50 13.72 448 752121 11520 34192842
Diastolic dysfunction 57.38 13.72 276 752293 5951 34198411
Aggression 57.16 13.72 549 752020 38415 34165947
Incorrect route of product administration 56.91 13.72 149 752420 14696 34189666
Thrombocytopenia 56.81 13.72 2766 749803 153481 34050881
Acute myeloid leukaemia 56.74 13.72 202 752367 18068 34186294
Oesophageal carcinoma 56.72 13.72 70 752499 9234 34195128
Somnolence 55.83 13.72 1895 750674 109221 34095141
Exposure during pregnancy 55.75 13.72 66 752503 8868 34195494
Joint swelling 55.59 13.72 930 751639 58960 34145402
Diverticulum 55.29 13.72 302 752267 6857 34197505
Drug reaction with eosinophilia and systemic symptoms 54.64 13.72 451 752118 32561 34171801
Interstitial lung disease 54.48 13.72 1033 751536 64249 34140113
No adverse event 54.32 13.72 281 752288 22646 34181716
Muscle haemorrhage 54.30 13.72 190 752379 3528 34200834
Arteriosclerosis coronary artery 53.84 13.72 456 752113 12029 34192333
Therapeutic product effect decreased 53.78 13.72 483 752086 34260 34170102
Chronic graft versus host disease 53.47 13.72 14 752555 4359 34200003
Hiatus hernia 53.43 13.72 314 752255 7331 34197031
Chest discomfort 53.38 13.72 1545 751024 52985 34151377
Ventricular hypokinesia 53.28 13.72 249 752320 5303 34199059
C-reactive protein increased 52.89 13.72 832 751737 53266 34151096
Drug hypersensitivity 51.25 13.72 1330 751239 79199 34125163
Depression 51.12 13.72 1646 750923 95452 34108910
Therapy non-responder 51.09 13.72 567 752002 38579 34165783
Abdominal wall haematoma 50.55 13.72 118 752451 1719 34202643
Drug withdrawal syndrome 50.49 13.72 237 752332 19597 34184765
Spinal epidural haematoma 50.27 13.72 47 752522 272 34204090
Arthralgia 50.16 13.72 3073 749496 166968 34037394
Injection site reaction 49.82 13.72 131 752438 12902 34191460
Osteonecrosis 49.39 13.72 160 752409 14730 34189632
Product monitoring error 49.26 13.72 206 752363 4175 34200187
Extradural haematoma 48.76 13.72 90 752479 1099 34203263
Withdrawal syndrome 48.52 13.72 124 752445 12331 34192031
Peptic ulcer 48.50 13.72 151 752418 2632 34201730
Mallory-Weiss syndrome 48.48 13.72 98 752471 1286 34203076
Electrocardiogram abnormal 48.29 13.72 353 752216 8894 34195468
Obsessive-compulsive disorder 48.26 13.72 30 752539 5534 34198828
Cytomegalovirus infection reactivation 48.11 13.72 25 752544 5093 34199269
Loss of personal independence in daily activities 48.03 13.72 469 752100 32710 34171652
Vomiting 47.86 13.72 4635 747934 242986 33961376
Bacterial infection 47.61 13.72 197 752372 16866 34187496
Toxicity to various agents 47.51 13.72 3691 748878 196671 34007691
Epilepsy 47.31 13.72 270 752299 21225 34183137
Intermittent claudication 47.16 13.72 132 752437 2162 34202200
Percutaneous coronary intervention 47.03 13.72 40 752529 200 34204162
Cardiac disorder 46.16 13.72 1236 751333 41890 34162472
Hemiplegia 45.95 13.72 282 752287 6690 34197672
Syringe issue 45.81 13.72 33 752536 5631 34198731
Appendicitis 45.79 13.72 164 752405 14643 34189719
Epstein-Barr virus infection 44.83 13.72 59 752510 7569 34196793
Poisoning deliberate 44.75 13.72 62 752507 7782 34196580
Adenovirus infection 44.69 13.72 29 752540 5228 34199134
Duodenitis 44.49 13.72 214 752355 4614 34199748
Colorectal cancer 43.66 13.72 24 752545 4737 34199625
Prostate cancer 43.54 13.72 596 751973 39053 34165309
Neutrophil count decreased 43.46 13.72 806 751763 50298 34154064
Viral mutation identified 43.43 13.72 6 752563 2948 34201414
Cytopenia 43.41 13.72 135 752434 12588 34191774
Tumour lysis syndrome 43.33 13.72 204 752365 16855 34187507
Suicide attempt 43.31 13.72 587 751982 38529 34165833
Exposure to toxic agent 43.05 13.72 175 752394 3500 34200862
Gastritis haemorrhagic 43.02 13.72 96 752473 1355 34203007
Device leakage 42.74 13.72 47 752522 6528 34197834
Haemobilia 42.69 13.72 48 752521 356 34204006
Nausea 42.60 13.72 6546 746023 333362 33871000
Retroperitoneal haemorrhage 42.54 13.72 148 752421 2740 34201622
Hypoglycaemia 42.48 13.72 1506 751063 53134 34151228
Traumatic intracranial haemorrhage 42.39 13.72 64 752505 654 34203708
Cystitis haemorrhagic 42.25 13.72 36 752533 5643 34198719
Dystonia 42.22 13.72 108 752461 10737 34193625
Apparent death 42.09 13.72 13 752556 3631 34200731
Tricuspid valve incompetence 41.84 13.72 356 752213 9404 34194958
Pseudomonas infection 41.81 13.72 132 752437 12250 34192112
Prostate cancer stage I 41.20 13.72 4 752565 2585 34201777
Heparin-induced thrombocytopenia 41.19 13.72 233 752336 5362 34199000
Hypogammaglobulinaemia 40.45 13.72 65 752504 7675 34196687
Ventricular extrasystoles 40.44 13.72 416 752153 11592 34192770
Haemoptysis 40.29 13.72 1013 751556 33993 34170369
Cardiac failure chronic 40.13 13.72 299 752270 7580 34196782
Gingival bleeding 39.92 13.72 273 752296 6727 34197635
Hepatocellular injury 39.28 13.72 298 752271 21913 34182449
Behaviour disorder 39.20 13.72 29 752540 4881 34199481
Eye haemorrhage 39.08 13.72 190 752379 4115 34200247
Stent placement 39.07 13.72 214 752355 4864 34199498
Contusion 38.86 13.72 1042 751527 35322 34169040
Accidental exposure to product 38.79 13.72 143 752426 12659 34191703
Blood pressure decreased 38.60 13.72 1414 751155 50101 34154261
Peripheral vascular disorder 38.59 13.72 212 752357 4824 34199538
Haematocrit decreased 38.49 13.72 937 751632 31279 34173083
Sinus node dysfunction 38.20 13.72 187 752382 4062 34200300
Candida infection 38.19 13.72 224 752345 17491 34186871
Cardiovascular disorder 38.07 13.72 357 752212 9699 34194663
Schizophrenia 37.99 13.72 81 752488 8585 34195777
Multiple injuries 37.94 13.72 108 752461 1787 34202575
Cardiac tamponade 37.92 13.72 218 752351 5048 34199314
Colitis 37.76 13.72 578 751991 37172 34167190
Ulcer haemorrhage 37.75 13.72 135 752434 2535 34201827
Lymphoma 37.71 13.72 140 752429 12367 34191995
Cytomegalovirus chorioretinitis 37.68 13.72 15 752554 3574 34200788
Red blood cell sedimentation rate abnormal 37.68 13.72 15 752554 3574 34200788
Venoocclusive disease 37.38 13.72 8 752561 2859 34201503
Cerebral haematoma 37.21 13.72 197 752372 4418 34199944
Klebsiella infection 37.18 13.72 80 752489 8451 34195911
Drug use disorder 37.18 13.72 22 752547 4169 34200193
Hyperlipidaemia 37.10 13.72 477 752092 14052 34190310
Peripheral arterial occlusive disease 37.09 13.72 235 752334 5639 34198723
Unintentional medical device removal 36.99 13.72 7 752562 2729 34201633
Neutrophil count increased 36.86 13.72 217 752352 16929 34187433
Mania 36.81 13.72 95 752474 9416 34194946
Drug withdrawal syndrome neonatal 36.59 13.72 16 752553 3603 34200759
Hepatitis B 36.49 13.72 45 752524 5938 34198424
Acute graft versus host disease in intestine 36.46 13.72 7 752562 2701 34201661
Gastrointestinal arteriovenous malformation 36.16 13.72 42 752527 324 34204038
Gastrointestinal ulcer haemorrhage 35.99 13.72 61 752508 693 34203669
Euphoric mood 35.93 13.72 41 752528 5600 34198762
Cerebellar haemorrhage 35.91 13.72 94 752475 1477 34202885
Acute hepatic failure 35.91 13.72 462 752107 13612 34190750
Sinus bradycardia 35.85 13.72 432 752137 12531 34191831
Gastrointestinal ulcer 35.72 13.72 99 752470 1612 34202750
Agitation 35.71 13.72 951 751618 56448 34147914
High density lipoprotein decreased 35.47 13.72 155 752414 3205 34201157
Transplant rejection 35.46 13.72 109 752460 10202 34194160
Procedural haemorrhage 35.40 13.72 125 752444 2332 34202030
Blood pressure increased 35.17 13.72 2273 750296 85829 34118533
Lipodystrophy acquired 35.07 13.72 14 752555 3330 34201032
Swollen tongue 35.00 13.72 474 752095 14131 34190231
Irritability 34.90 13.72 351 752218 24339 34180023
Blood phosphorus increased 34.83 13.72 71 752498 7650 34196712
Miosis 34.82 13.72 98 752471 9437 34194925
Disinhibition 34.67 13.72 13 752556 3213 34201149
Vascular graft occlusion 34.54 13.72 52 752517 530 34203832
Embolic stroke 34.47 13.72 188 752381 4266 34200096
Pulmonary alveolar haemorrhage 34.34 13.72 278 752291 7234 34197128
Muscle spasms 34.24 13.72 1958 750611 73043 34131319
Hyperbilirubinaemia 34.21 13.72 217 752352 16626 34187736
Musculoskeletal stiffness 34.08 13.72 755 751814 45925 34158437
Prostate cancer stage IV 34.05 13.72 6 752563 2462 34201900
Systemic candida 33.85 13.72 19 752550 3707 34200655
Thalamus haemorrhage 33.83 13.72 70 752499 935 34203427
Aortic aneurysm 33.81 13.72 256 752313 6523 34197839
Stress 33.74 13.72 455 752114 29892 34174470
Heart rate decreased 33.73 13.72 909 751660 30836 34173526
Vascular stent occlusion 33.73 13.72 30 752539 161 34204201
Hepatitis B reactivation 33.72 13.72 21 752548 3870 34200492
Tongue haematoma 33.71 13.72 26 752543 110 34204252
Sickle cell anaemia with crisis 33.59 13.72 23 752546 4030 34200332
Blood bilirubin increased 33.50 13.72 601 751968 37695 34166667
Fat embolism 33.46 13.72 30 752539 163 34204199
Alcohol abuse 33.37 13.72 31 752538 4659 34199703
Ventricular hypertrophy 33.35 13.72 191 752378 4416 34199946
Hepatojugular reflux 33.27 13.72 52 752517 549 34203813
Paranoia 33.25 13.72 140 752429 11928 34192434
Encephalopathy 33.24 13.72 547 752022 34772 34169590
Peptic ulcer haemorrhage 33.11 13.72 50 752519 511 34203851
Aortic stenosis 33.09 13.72 183 752386 4175 34200187
Therapy interrupted 32.94 13.72 167 752402 13530 34190832
Mucormycosis 32.88 13.72 48 752521 5894 34198468
Hyperammonaemia 32.77 13.72 54 752515 6313 34198049
Diarrhoea 32.71 13.72 7668 744901 382244 33822118
Agranulocytosis 32.70 13.72 341 752228 23480 34180882
Alopecia 32.48 13.72 351 752218 24004 34180358
Fatigue 32.37 13.72 8705 743864 361948 33842414
Basilar artery thrombosis 32.34 13.72 33 752536 216 34204146
Splenic haematoma 32.29 13.72 29 752540 158 34204204
Pallor 32.24 13.72 747 751822 24733 34179629
Large intestinal haemorrhage 32.24 13.72 93 752476 1551 34202811
Paradoxical drug reaction 32.05 13.72 16 752553 3335 34201027
Haemorrhage urinary tract 32.03 13.72 101 752468 1773 34202589
Gastrooesophageal reflux disease 31.92 13.72 1055 751514 36869 34167493
Aplasia 31.85 13.72 31 752538 4557 34199805
Ecchymosis 31.77 13.72 253 752316 6550 34197812
Electrocardiogram ST segment depression 31.72 13.72 121 752448 2347 34202015
Bone erosion 31.69 13.72 24 752545 3991 34200371
Arterial occlusive disease 31.59 13.72 180 752389 4154 34200208
Lacunar infarction 31.45 13.72 141 752428 2949 34201413
Coronary artery aneurysm 31.29 13.72 22 752547 78 34204284
Sleep terror 31.19 13.72 6 752563 2312 34202050
Generalised tonic-clonic seizure 31.19 13.72 298 752271 20876 34183486
Alanine aminotransferase abnormal 31.04 13.72 33 752536 4655 34199707
Renal cancer 30.91 13.72 76 752493 7659 34196703
Haemorrhagic cerebral infarction 30.90 13.72 62 752507 809 34203553
Immune effector cell-associated neurotoxicity syndrome 30.87 13.72 21 752548 3692 34200670
Gout 30.74 13.72 584 751985 18669 34185693
Tenosynovitis 30.45 13.72 32 752537 4538 34199824
Blood creatinine increased 30.44 13.72 2407 750162 92569 34111793
Coronary artery perforation 30.44 13.72 18 752551 43 34204319
Rash maculo-papular 30.41 13.72 430 752139 28021 34176341
Angiocardiogram 30.37 13.72 29 752540 173 34204189
Chromaturia 30.32 13.72 460 752109 14060 34190302
Cardiac ventricular thrombosis 30.28 13.72 73 752496 1087 34203275
Device use error 30.21 13.72 7 752562 2368 34201994
Enterococcal infection 30.17 13.72 101 752468 9205 34195157
Left ventricular failure 30.16 13.72 202 752367 4942 34199420
Pneumonia cytomegaloviral 30.10 13.72 14 752555 3040 34201322
Product storage error 30.02 13.72 83 752486 8039 34196323
Hemiparesis 29.97 13.72 492 752077 15286 34189076
Puncture site haemorrhage 29.95 13.72 35 752534 272 34204090
Acute lymphocytic leukaemia recurrent 29.93 13.72 14 752555 3030 34201332
Subcapsular renal haematoma 29.72 13.72 41 752528 383 34203979
Injection site erythema 29.70 13.72 210 752359 15689 34188673
Product prescribing error 29.58 13.72 674 751895 22253 34182109
Fungal infection 29.51 13.72 211 752358 15724 34188638
Bundle branch block left 29.38 13.72 225 752344 5754 34198608
Abnormal behaviour 29.37 13.72 370 752199 24599 34179763
Helicobacter gastritis 29.33 13.72 75 752494 1161 34203201
Heart rate irregular 29.32 13.72 491 752078 15316 34189046
Cerebral artery occlusion 29.27 13.72 56 752513 704 34203658
Neutropenic sepsis 29.19 13.72 175 752394 13592 34190770
Myocardial rupture 29.16 13.72 27 752542 154 34204208
Skin toxicity 29.15 13.72 36 752533 4748 34199614
Mediastinal haematoma 29.05 13.72 22 752547 90 34204272
Cardiac aneurysm 29.01 13.72 64 752505 896 34203466
Nocturia 29.00 13.72 342 752227 9868 34194494
Carotid artery disease 28.88 13.72 62 752507 851 34203511
Haemorrhagic infarction 28.85 13.72 43 752526 434 34203928
Haemothorax 28.75 13.72 161 752408 3691 34200671
Respiratory depression 28.70 13.72 218 752351 16027 34188335
Injection site swelling 28.60 13.72 139 752430 11388 34192974
Coronary angioplasty 28.52 13.72 40 752529 380 34203982
Peripheral artery stenosis 28.49 13.72 60 752509 812 34203550
Developmental delay 28.48 13.72 12 752557 2763 34201599
Palmar-plantar erythrodysaesthesia syndrome 28.45 13.72 228 752341 16567 34187795
Subcutaneous haematoma 28.40 13.72 65 752504 934 34203428
Anxiety 28.38 13.72 1802 750767 97626 34106736
Gastrointestinal polyp haemorrhage 28.33 13.72 36 752533 308 34204054
Poisoning 28.31 13.72 151 752418 12075 34192287
Basal ganglia haemorrhage 28.28 13.72 62 752507 864 34203498
Nocardiosis 28.25 13.72 26 752543 3925 34200437
Atrioventricular block complete 28.20 13.72 316 752253 9003 34195359
Psychiatric decompensation 28.12 13.72 14 752555 2923 34201439
Inappropriate schedule of product administration 27.96 13.72 1077 751492 61219 34143143
Prostate cancer stage III 27.94 13.72 3 752566 1790 34202572
Tuberculosis 27.87 13.72 93 752476 8484 34195878
Urinary bladder haemorrhage 27.85 13.72 92 752477 1657 34202705
Pulmonary tuberculosis 27.70 13.72 37 752532 4717 34199645
Pharyngeal haemorrhage 27.69 13.72 55 752514 712 34203650
Glomerular filtration rate decreased 27.60 13.72 412 752157 12549 34191813
Psychomotor skills impaired 27.57 13.72 26 752543 3880 34200482
Leukoencephalopathy 27.54 13.72 30 752539 4185 34200177
Hyperammonaemic encephalopathy 27.37 13.72 8 752561 2316 34202046
Blood creatine phosphokinase MB increased 27.21 13.72 96 752473 1790 34202572
Orthostatic hypotension 27.20 13.72 741 751828 25178 34179184
Bacteraemia 27.17 13.72 282 752287 19435 34184927
Coma 27.07 13.72 762 751807 44916 34159446
Blood creatine phosphokinase increased 27.06 13.72 1203 751366 43654 34160708
Hypertensive crisis 27.05 13.72 298 752271 8453 34195909
Hepatic function abnormal 26.81 13.72 738 751831 43625 34160737
Arterial restenosis 26.80 13.72 18 752551 58 34204304
Diffuse large B-cell lymphoma 26.73 13.72 76 752493 7294 34197068
Occult blood 26.38 13.72 58 752511 810 34203552
Angiopathy 26.38 13.72 167 752402 4006 34200356
Troponin increased 26.22 13.72 367 752202 11022 34193340
Atrial flutter 26.11 13.72 476 752093 15098 34189264
Hepatocellular carcinoma 26.10 13.72 79 752490 7430 34196932
Hallucination, auditory 26.06 13.72 150 752419 11767 34192595
Second primary malignancy 25.97 13.72 85 752484 7801 34196561
Ventricular dysfunction 25.76 13.72 158 752411 3747 34200615
Pulmonary haematoma 25.70 13.72 17 752552 53 34204309
Electrocardiogram ST segment elevation 25.68 13.72 197 752372 5041 34199321
Mobility decreased 25.66 13.72 475 752094 29653 34174709
Platelet dysfunction 25.62 13.72 31 752538 251 34204111
Scrotal haematoma 25.58 13.72 19 752550 75 34204287
Hyperthermia 25.41 13.72 129 752440 10448 34193914
Splenic rupture 25.38 13.72 82 752487 1459 34202903
Respiratory failure 25.38 13.72 2002 750567 106570 34097792
Metastases to liver 25.26 13.72 181 752388 13482 34190880
Herpes simplex 25.18 13.72 51 752518 5508 34198854
Atrioventricular block 25.12 13.72 275 752294 7788 34196574
Extrapyramidal disorder 25.11 13.72 168 752401 12712 34191650
Lymphadenopathy 25.11 13.72 446 752123 28017 34176345
Oesophageal ulcer 25.02 13.72 141 752428 3240 34201122
Hyperkalaemia 24.99 13.72 1775 750794 67614 34136748
Rheumatoid arthritis 24.98 13.72 629 751940 37609 34166753
Systemic infection 24.98 13.72 195 752374 5017 34199345
Colonic haematoma 24.95 13.72 14 752555 29 34204333
Helicobacter test positive 24.95 13.72 57 752512 818 34203544
Mouth haemorrhage 24.94 13.72 198 752371 5121 34199241
Bradypnoea 24.89 13.72 15 752554 2814 34201548
Loss of consciousness 24.87 13.72 2085 750484 80582 34123780
Prostate cancer stage II 24.84 13.72 9 752560 2272 34202090
Stenosis 24.82 13.72 79 752490 1394 34202968
Head injury 24.73 13.72 538 752031 17622 34186740
Large intestine polyp 24.69 13.72 270 752299 7644 34196718
Sinus arrest 24.62 13.72 88 752481 1652 34202710
Antipsychotic drug level below therapeutic 24.60 13.72 12 752557 2535 34201827
Catheter site haematoma 24.56 13.72 24 752545 148 34204214
Body height decreased 24.42 13.72 154 752415 3689 34200673
Platelet function test abnormal 24.40 13.72 21 752548 107 34204255
Device related infection 24.38 13.72 245 752324 16992 34187370
Strongyloidiasis 24.38 13.72 14 752555 2697 34201665
Coagulopathy 24.37 13.72 578 751991 19211 34185151
Haemorrhage subcutaneous 24.37 13.72 107 752462 2217 34202145
Tongue oedema 24.21 13.72 128 752441 2869 34201493
Acute respiratory distress syndrome 24.17 13.72 403 752166 25566 34178796
Hepatitis C 24.12 13.72 119 752450 9711 34194651
Labelled drug-disease interaction medication error 23.98 13.72 21 752548 110 34204252
Inflammation 23.82 13.72 447 752122 27848 34176514
Myelodysplastic syndrome 23.58 13.72 282 752287 18926 34185436
Joint ankylosis 23.57 13.72 3 752566 1569 34202793
Aortic valve incompetence 23.56 13.72 212 752357 5692 34198670
Oedema peripheral 23.55 13.72 2935 749634 116877 34087485
Bleeding time prolonged 23.54 13.72 47 752522 611 34203751
Myocarditis 23.52 13.72 185 752384 13497 34190865
Bladder tamponade 23.46 13.72 42 752527 500 34203862
Haemorrhagic diathesis 23.25 13.72 121 752448 2695 34201667
Low density lipoprotein increased 22.96 13.72 169 752400 4267 34200095
Uveitis 22.94 13.72 84 752485 7451 34196911
Benign prostatic hyperplasia 22.91 13.72 439 752130 14056 34190306
Prothrombin time prolonged 22.84 13.72 306 752263 9100 34195262
Ventricular arrhythmia 22.84 13.72 200 752369 5328 34199034
Erythema 22.82 13.72 1624 750945 87156 34117206
Mitochondrial toxicity 22.79 13.72 15 752554 2684 34201678
Oesophageal intramural haematoma 22.73 13.72 11 752558 14 34204348
Sudden cardiac death 22.71 13.72 147 752422 3554 34200808
Hypertension 22.66 13.72 3309 749260 133134 34071228
Haemorrhagic erosive gastritis 22.63 13.72 26 752543 198 34204164
Antipsychotic drug level increased 22.61 13.72 30 752539 3835 34200527
Aplastic anaemia 22.50 13.72 120 752449 9596 34194766
Staphylococcal infection 22.46 13.72 535 752034 32225 34172137
Growth retardation 22.44 13.72 6 752563 1842 34202520
Lymphocyte count decreased 22.41 13.72 347 752222 22275 34182087
Increased tendency to bruise 22.34 13.72 157 752412 3904 34200458
Cerebrovascular disorder 22.33 13.72 88 752481 1734 34202628
Ischaemia 22.31 13.72 172 752397 4408 34199954
Neoplasm malignant 22.29 13.72 298 752271 19607 34184755
Ejection fraction decreased 22.25 13.72 555 752014 18599 34185763
Haemarthrosis 22.22 13.72 133 752436 3126 34201236
Blood glucose increased 22.22 13.72 1696 750873 65022 34139340
Respiratory tract haemorrhage 22.22 13.72 69 752500 1201 34203161
Gastrointestinal angiodysplasia 22.18 13.72 44 752525 569 34203793
Aortic intramural haematoma 22.00 13.72 13 752556 31 34204331
Muscular weakness 21.99 13.72 1839 750730 71058 34133304
Device issue 21.95 13.72 122 752447 9655 34194707
Bundle branch block right 21.90 13.72 253 752316 7263 34197099
Microcytic anaemia 21.84 13.72 106 752463 2294 34202068
Social avoidant behaviour 21.67 13.72 21 752548 3093 34201269
Vertigo 21.64 13.72 711 751858 24825 34179537
Angioplasty 21.64 13.72 59 752510 951 34203411
Traumatic haematoma 21.58 13.72 48 752521 676 34203686
Venous pressure jugular increased 21.55 13.72 51 752518 750 34203612
Aortic aneurysm rupture 21.54 13.72 60 752509 980 34203382
Aortic valve stenosis 21.53 13.72 115 752454 2588 34201774
Juvenile idiopathic arthritis 21.49 13.72 7 752562 1890 34202472
Blindness transient 21.48 13.72 100 752469 2126 34202236
Spontaneous haematoma 21.48 13.72 40 752529 492 34203870
Hypomania 21.47 13.72 12 752557 2347 34202015
Viral load increased 21.40 13.72 14 752555 2513 34201849
Human herpesvirus 6 infection 21.36 13.72 9 752560 2072 34202290
Non-cardiac chest pain 21.28 13.72 162 752407 4135 34200227
Foetal exposure timing unspecified 21.27 13.72 26 752543 213 34204149
Eosinophilia 21.23 13.72 417 752152 25805 34178557
Implant site haematoma 21.21 13.72 16 752553 65 34204297
Respiratory distress 21.12 13.72 595 751974 35070 34169292
Cardiac valve disease 21.11 13.72 127 752442 2991 34201371
Osteonecrosis of jaw 21.07 13.72 265 752304 17624 34186738
Sleep disorder 21.04 13.72 520 752049 31168 34173194
Electrocardiogram Q wave abnormal 21.00 13.72 36 752533 413 34203949
Blood urea increased 20.96 13.72 826 751743 29538 34174824
Intra-abdominal haematoma 20.87 13.72 71 752498 1299 34203063
Coagulation time abnormal 20.85 13.72 21 752548 135 34204227
Hypercholesterolaemia 20.84 13.72 284 752285 8478 34195884
Incision site haemorrhage 20.79 13.72 40 752529 505 34203857
Carotid bruit 20.71 13.72 23 752546 168 34204194
Peripheral ischaemia 20.59 13.72 200 752369 5487 34198875
Metastases to lung 20.54 13.72 117 752452 9203 34195159
Autism spectrum disorder 20.44 13.72 12 752557 2284 34202078
Salivary hypersecretion 20.44 13.72 106 752463 8538 34195824
Intestinal diaphragm disease 20.42 13.72 26 752543 223 34204139
Coronary artery dissection 20.35 13.72 29 752540 280 34204082
Hypertriglyceridaemia 20.31 13.72 103 752466 8345 34196017
Vitreous haemorrhage 20.31 13.72 103 752466 2270 34202092
Polycythaemia vera 20.25 13.72 30 752539 301 34204061
Ankylosing spondylitis 20.17 13.72 58 752511 5546 34198816
Haemorrhoidal haemorrhage 20.15 13.72 143 752426 3568 34200794
Device interaction 20.14 13.72 41 752528 541 34203821
Dysmorphism 20.03 13.72 23 752546 3133 34201229
Arterial spasm 19.99 13.72 17 752552 85 34204277
Disturbance in attention 19.99 13.72 416 752153 25529 34178833
Computerised tomogram coronary artery abnormal 19.95 13.72 24 752545 193 34204169
Anion gap 19.94 13.72 52 752517 815 34203547
Asthma 19.90 13.72 734 751835 41922 34162440
Electrocardiogram PR prolongation 19.90 13.72 53 752516 842 34203520
Hyphaema 19.89 13.72 41 752528 546 34203816
Coronary ostial stenosis 19.87 13.72 16 752553 73 34204289
Drug level decreased 19.82 13.72 94 752475 7752 34196610
Pneumonia fungal 19.79 13.72 82 752487 7018 34197344
Ageusia 19.79 13.72 322 752247 9986 34194376
Precancerous skin lesion 19.77 13.72 42 752527 572 34203790
Basilar artery stenosis 19.76 13.72 10 752559 15 34204347
Intracardiac thrombus 19.75 13.72 106 752463 2390 34201972
Left ventricular dysfunction 19.74 13.72 314 752255 9693 34194669
Small intestine ulcer 19.70 13.72 35 752534 414 34203948
Colitis microscopic 19.70 13.72 101 752468 2236 34202126
Fistula 19.69 13.72 78 752491 6762 34197600
Chronic obstructive pulmonary disease 19.68 13.72 1263 751306 47655 34156707
Chronic kidney disease 19.61 13.72 1080 751489 40130 34164232
Orthostatic intolerance 19.59 13.72 50 752519 773 34203589
Ill-defined disorder 19.55 13.72 198 752371 13711 34190651
Philadelphia positive acute lymphocytic leukaemia 19.54 13.72 11 752558 23 34204339
Full blood count decreased 19.52 13.72 519 752050 17569 34186793
Hypofibrinogenaemia 19.50 13.72 6 752563 1680 34202682
Dermatitis exfoliative generalised 19.49 13.72 31 752538 3676 34200686
Granulocytopenia 19.48 13.72 74 752495 6493 34197869
Meningitis cryptococcal 19.45 13.72 14 752555 2390 34201972
Extrasystoles 19.42 13.72 145 752424 3678 34200684
Blood pressure fluctuation 19.38 13.72 695 751874 24554 34179808
Cerebral microhaemorrhage 19.36 13.72 15 752554 64 34204298
Vessel puncture site haematoma 19.33 13.72 13 752556 42 34204320
Device malfunction 19.29 13.72 138 752431 10283 34194079
Renal haemorrhage 19.19 13.72 72 752497 1385 34202977
Cataract 19.18 13.72 717 751852 25469 34178893
Arterial stenosis 19.16 13.72 62 752507 1104 34203258
Page kidney 19.12 13.72 13 752556 43 34204319
JC virus infection 19.02 13.72 12 752557 2196 34202166
Cystic fibrosis 19.00 13.72 6 752563 1652 34202710
Mycobacterial infection 18.98 13.72 14 752555 2360 34202002
Kidney transplant rejection 18.84 13.72 90 752479 7407 34196955
Haemorrhagic cholecystitis 18.81 13.72 16 752553 80 34204282
Terminal state 18.77 13.72 35 752534 3899 34200463
Basal ganglia infarction 18.76 13.72 23 752546 189 34204173
Cerebral artery stenosis 18.73 13.72 30 752539 324 34204038
Cerebral mass effect 18.69 13.72 55 752514 928 34203434
Atrioventricular block first degree 18.62 13.72 207 752362 5885 34198477
Periorbital haemorrhage 18.61 13.72 17 752552 95 34204267
Erosive duodenitis 18.56 13.72 80 752489 1644 34202718
Brain stem haemorrhage 18.55 13.72 53 752516 879 34203483
Polyomavirus-associated nephropathy 18.51 13.72 34 752535 3810 34200552
Actinic elastosis 18.51 13.72 13 752556 46 34204316
Surgery 18.49 13.72 205 752364 13952 34190410
Blood urine present 18.47 13.72 332 752237 10502 34193860
Transplant failure 18.41 13.72 30 752539 3523 34200839
Circulatory collapse 18.41 13.72 588 751981 20450 34183912
Device embolisation 18.36 13.72 10 752559 19 34204343
Myopathy 18.28 13.72 350 752219 11204 34193158
Silent myocardial infarction 18.27 13.72 32 752537 374 34203988
Finger amputation 18.18 13.72 21 752548 161 34204201
Vertebral artery stenosis 18.11 13.72 19 752550 129 34204233
Adrenal insufficiency 18.11 13.72 204 752365 13843 34190519
Migraine 18.03 13.72 266 752303 17212 34187150
Diverticulum oesophageal 18.00 13.72 8 752561 7 34204355
Diffuse large B-cell lymphoma recurrent 17.93 13.72 26 752543 3202 34201160
Conjunctival haemorrhage 17.93 13.72 120 752449 2935 34201427
Encephalitis 17.91 13.72 88 752481 7189 34197173
Electrocardiogram T wave inversion 17.83 13.72 95 752474 2136 34202226
Orthopnoea 17.76 13.72 178 752391 4925 34199437
Pneumatosis intestinalis 17.76 13.72 36 752533 3887 34200475
Palmoplantar keratoderma 17.68 13.72 10 752559 1943 34202419
Hyperreflexia 17.64 13.72 26 752543 3180 34201182
Pneumonitis 17.64 13.72 575 751994 33303 34171059
Lymphoproliferative disorder 17.63 13.72 20 752549 2739 34201623
Blood parathyroid hormone decreased 17.60 13.72 5 752564 1475 34202887
Small intestine polyp 17.60 13.72 9 752560 14 34204348
Drug effective for unapproved indication 17.58 13.72 18 752551 2584 34201778
Metastases to central nervous system 17.55 13.72 104 752465 8101 34196261
Hypertensive heart disease 17.54 13.72 100 752469 2308 34202054
Metabolic acidosis 17.43 13.72 1127 751442 42553 34161809
Escherichia infection 17.38 13.72 105 752464 8140 34196222
Epigastric discomfort 17.38 13.72 94 752475 2126 34202236
Acute graft versus host disease in liver 17.36 13.72 6 752563 1560 34202802
Intestinal haematoma 17.31 13.72 16 752553 91 34204271
Depression suicidal 17.30 13.72 17 752552 2488 34201874
Affective disorder 17.30 13.72 43 752526 4317 34200045
Gastrointestinal disorder 17.25 13.72 578 751991 33370 34170992
Anal fistula 17.23 13.72 59 752510 5340 34199022
Hyperthermia malignant 17.20 13.72 13 752556 2164 34202198
Haemoperitoneum 17.19 13.72 81 752488 1731 34202631
Talipes 17.19 13.72 10 752559 1913 34202449
Arteriovenous malformation 17.19 13.72 47 752522 759 34203603
Hypocoagulable state 17.11 13.72 52 752517 894 34203468
Hepatic fibrosis 17.08 13.72 47 752522 4560 34199802
Aortic bypass 17.04 13.72 8 752561 9 34204353
Tooth disorder 17.00 13.72 329 752240 10553 34193809
Osteolysis 16.86 13.72 26 752543 3122 34201240
Gastric ulcer perforation 16.84 13.72 56 752513 1012 34203350
Prescription drug used without a prescription 16.84 13.72 13 752556 2141 34202221
Wound haemorrhage 16.81 13.72 89 752480 1996 34202366
Hernia 16.81 13.72 295 752274 9288 34195074
Fanconi syndrome 16.77 13.72 8 752561 1712 34202650
Pneumonia aspiration 16.76 13.72 734 751835 41169 34163193
Disseminated intravascular coagulation 16.74 13.72 350 752219 21466 34182896
Cerebral aspergillosis 16.73 13.72 5 752564 1427 34202935
Haematoma muscle 16.71 13.72 66 752503 1302 34203060
Coronary artery insufficiency 16.66 13.72 15 752554 82 34204280
Reye's syndrome 16.61 13.72 8 752561 10 34204352
Brain stem infarction 16.60 13.72 63 752506 1219 34203143
Brain contusion 16.57 13.72 47 752522 776 34203586
Periorbital oedema 16.54 13.72 138 752431 3624 34200738
Pharyngeal haematoma 16.52 13.72 13 752556 57 34204305
Illness 16.46 13.72 199 752370 13330 34191032
Aneurysm 16.37 13.72 83 752486 1829 34202533
Complications of transplanted kidney 16.37 13.72 48 752521 4561 34199801
Pruritus genital 16.36 13.72 14 752555 2190 34202172
Dermatitis acneiform 16.32 13.72 73 752496 6116 34198246
Product quality issue 16.30 13.72 263 752306 16772 34187590
Abscess 16.28 13.72 169 752400 11648 34192714
Cerebellar infarction 16.22 13.72 83 752486 1836 34202526
Swelling 16.15 13.72 746 751823 41620 34162742
Atrioventricular block second degree 16.15 13.72 138 752431 3650 34200712
Foetal anticonvulsant syndrome 16.13 13.72 3 752566 1184 34203178
Needle issue 16.09 13.72 73 752496 6092 34198270
Hepatic necrosis 16.06 13.72 138 752431 3656 34200706
Cardiac valve replacement complication 16.05 13.72 11 752558 37 34204325
Disturbance in social behaviour 16.03 13.72 10 752559 1841 34202521
Incision site haematoma 16.02 13.72 15 752554 87 34204275
Dizziness postural 16.00 13.72 203 752366 5961 34198401
Cerebral ventricular rupture 15.93 13.72 21 752548 187 34204175
Disseminated cryptococcosis 15.91 13.72 5 752564 1381 34202981
Diverticulitis intestinal haemorrhagic 15.89 13.72 28 752541 329 34204033
Cardiotoxicity 15.89 13.72 65 752504 5583 34198779
Hepatic cytolysis 15.87 13.72 218 752351 14278 34190084
Stent-graft endoleak 15.85 13.72 10 752559 28 34204334
Erosive oesophagitis 15.83 13.72 69 752500 1425 34202937
Faeces pale 15.80 13.72 66 752503 1337 34203025
Arrhythmia 15.79 13.72 932 751637 34876 34169486
Toxic anterior segment syndrome 15.79 13.72 3 752566 1166 34203196
Blue toe syndrome 15.77 13.72 18 752551 136 34204226
Electrocardiogram QT prolonged 15.63 13.72 721 751848 40231 34164131
Polyneuropathy 15.61 13.72 226 752343 14670 34189692
Frequent bowel movements 15.59 13.72 188 752381 12599 34191763
Myoclonus 15.57 13.72 223 752346 14502 34189860
Psoriasis 15.49 13.72 680 751889 38132 34166230
Gastric mucosal lesion 15.47 13.72 37 752532 548 34203814
Tardive dyskinesia 15.44 13.72 68 752501 5722 34198640
Anastomotic ulcer haemorrhage 15.36 13.72 9 752560 21 34204341
Muscle injury 15.34 13.72 68 752501 1415 34202947
Prostatic adenoma 15.34 13.72 19 752550 158 34204204
Varicella zoster virus infection 15.30 13.72 10 752559 1796 34202566
Tongue disorder 15.30 13.72 61 752508 5278 34199084
Vascular device infection 15.29 13.72 43 752526 4142 34200220
Intestinal obstruction 15.29 13.72 374 752195 22448 34181914
Disease recurrence 15.28 13.72 349 752220 21141 34183221
Vessel puncture site haemorrhage 15.23 13.72 14 752555 79 34204283
Psychomotor hyperactivity 15.22 13.72 133 752436 9489 34194873
Idiopathic pulmonary fibrosis 15.20 13.72 129 752440 3405 34200957
Carcinogenicity 15.19 13.72 12 752557 53 34204309
Rhythm idioventricular 15.19 13.72 26 752543 298 34204064
Extraocular muscle disorder 15.18 13.72 20 752549 178 34204184
Hypotonia neonatal 15.18 13.72 5 752564 1340 34203022
Implant site haemorrhage 15.17 13.72 15 752554 94 34204268
Staphylococcal bacteraemia 15.13 13.72 113 752456 8339 34196023
Persecutory delusion 15.12 13.72 20 752549 2560 34201802
Cardiac murmur 15.11 13.72 245 752324 7592 34196770
Oesophagitis haemorrhagic 15.11 13.72 22 752547 217 34204145
Barrett's oesophagus 15.10 13.72 32 752537 435 34203927
Cholestasis 15.09 13.72 453 752116 26495 34177867
Drug interaction 15.08 13.72 5251 747318 220695 33983667
Cerebral ischaemia 15.07 13.72 205 752364 6117 34198245
Degenerative mitral valve disease 15.06 13.72 24 752545 258 34204104
Steroid diabetes 15.04 13.72 15 752554 2180 34202182
Neutropenic colitis 14.97 13.72 28 752541 3116 34201246
Aortic valve sclerosis 14.97 13.72 52 752517 962 34203400
Pneumonia 14.96 13.72 7331 745238 355296 33849066
Blood potassium increased 14.95 13.72 463 752106 16032 34188330
Infective exacerbation of chronic obstructive airways disease 14.91 13.72 79 752490 1772 34202590
Diabetic foot 14.88 13.72 107 752462 2681 34201681
Hypoalbuminaemia 14.84 13.72 179 752390 11995 34192367
Altered state of consciousness 14.84 13.72 377 752192 22516 34181846
Mesenteric artery thrombosis 14.79 13.72 31 752538 418 34203944
Ruptured cerebral aneurysm 14.75 13.72 17 752552 130 34204232
Pneumocystis jirovecii infection 14.73 13.72 10 752559 1760 34202602
Labelled drug-drug interaction issue 14.67 13.72 26 752543 307 34204055
Hepatic encephalopathy 14.63 13.72 225 752344 14460 34189902
Arterial stent insertion 14.60 13.72 14 752555 84 34204278
Essential hypertension 14.59 13.72 114 752455 2934 34201428
Drug dose omission by device 14.56 13.72 16 752553 2223 34202139
Systolic dysfunction 14.50 13.72 104 752465 2604 34201758
Dilatation atrial 14.49 13.72 84 752485 1951 34202411
Splenic haemorrhage 14.46 13.72 31 752538 425 34203937
Peripheral artery occlusion 14.44 13.72 74 752495 1638 34202724
Acute kidney injury 14.36 13.72 7003 745566 297985 33906377
Clostridium difficile colitis 14.35 13.72 245 752324 15485 34188877
Pneumonia klebsiella 14.34 13.72 31 752538 3269 34201093
Carcinoma in situ of skin 14.32 13.72 13 752556 72 34204290
Shone complex 14.32 13.72 13 752556 72 34204290
Coronary revascularisation 14.32 13.72 9 752560 25 34204337
Psychotic symptom 14.30 13.72 10 752559 1733 34202629
Exercise tolerance decreased 14.27 13.72 173 752396 5025 34199337
Facial bones fracture 14.20 13.72 98 752471 2422 34201940
Tendon rupture 14.20 13.72 221 752348 6791 34197571
Tic 14.18 13.72 14 752555 2044 34202318
Red blood cell sedimentation rate 14.16 13.72 4 752565 1184 34203178
Cerebral small vessel ischaemic disease 14.12 13.72 28 752541 362 34204000
Malaise 14.12 13.72 3670 748899 182155 34022207
Platelet aggregation test 14.11 13.72 10 752559 36 34204326
Splenic injury 14.08 13.72 9 752560 26 34204336
Oesophageal haemorrhage 14.06 13.72 61 752508 1257 34203105
Gastrointestinal toxicity 14.05 13.72 23 752546 2696 34201666
Enterocolitis 14.04 13.72 108 752461 7918 34196444
Haemorrhage coronary artery 14.02 13.72 7 752562 10 34204352
Coronary artery reocclusion 14.02 13.72 14 752555 89 34204273
Thrombotic stroke 14.01 13.72 23 752546 254 34204108
Fungaemia 13.96 13.72 21 752548 2547 34201815
Ocular myasthenia 13.88 13.72 21 752548 215 34204147
Multiple sclerosis relapse 13.85 13.72 199 752370 12934 34191428
Angiogram abnormal 13.84 13.72 9 752560 27 34204335
Platelet aggregation inhibition 13.84 13.72 8 752561 18 34204344
Ocular retrobulbar haemorrhage 13.84 13.72 8 752561 18 34204344
Histoplasmosis disseminated 13.82 13.72 6 752563 1357 34203005
Headache 13.77 13.72 3980 748589 196655 34007707
Coronary artery embolism 13.76 13.72 17 752552 141 34204221

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Myocardial infarction 2895.50 11.65 8374 1376398 175755 78183861
Gastrointestinal haemorrhage 2828.66 11.65 7224 1377548 140495 78219121
Coronary artery disease 1905.45 11.65 3784 1380988 61690 78297926
Drug ineffective 1876.55 11.65 11070 1373702 1069843 77289773
Acute myocardial infarction 1763.43 11.65 4038 1380734 72998 78286618
Labelled drug-drug interaction medication error 1512.46 11.65 2122 1382650 25528 78334088
Cerebrovascular accident 1250.37 11.65 5679 1379093 149613 78210003
Cardiac failure congestive 1190.27 11.65 5266 1379506 137136 78222480
Off label use 1113.31 11.65 10241 1374531 896974 77462642
Melaena 957.09 11.65 2771 1382001 58119 78301497
Upper gastrointestinal haemorrhage 901.61 11.65 2128 1382644 39252 78320364
Angina pectoris 858.57 11.65 2401 1382371 49331 78310285
Treatment failure 753.06 11.65 1120 1383652 169366 78190250
Angina unstable 741.88 11.65 1156 1383616 15371 78344245
Vascular stent thrombosis 706.84 11.65 556 1384216 3154 78356462
Drug intolerance 577.10 11.65 2490 1382282 261629 78097987
Cerebral haemorrhage 544.40 11.65 2214 1382558 55459 78304157
Syncope 541.96 11.65 5124 1379648 174325 78185291
Gastric haemorrhage 540.19 11.65 952 1383820 14098 78345518
Lower gastrointestinal haemorrhage 520.35 11.65 974 1383798 15151 78344465
Coronary arterial stent insertion 501.23 11.65 571 1384201 5473 78354143
Coronary artery bypass 493.09 11.65 567 1384205 5495 78354121
Aspirin-exacerbated respiratory disease 492.90 11.65 290 1384482 917 78358699
Haematuria 490.58 11.65 2431 1382341 66405 78293211
Rhabdomyolysis 482.07 11.65 3256 1381516 99875 78259741
Alopecia 465.41 11.65 2248 1382524 229107 78130509
Product use in unapproved indication 461.04 11.65 2508 1382264 247851 78111765
Haematemesis 456.26 11.65 1959 1382813 50305 78309311
Psoriatic arthropathy 439.49 11.65 423 1384349 77576 78282040
Drug abuse 434.57 11.65 1412 1383360 161279 78198337
Chest pain 431.62 11.65 7094 1377678 275210 78084406
Haemorrhage 416.46 11.65 2861 1381911 88257 78271359
Synovitis 415.37 11.65 1290 1383482 149444 78210172
Febrile neutropenia 413.85 11.65 2335 1382437 228664 78130952
Transient ischaemic attack 412.41 11.65 1912 1382860 50783 78308833
Coronary artery stenosis 394.04 11.65 747 1384025 11737 78347879
Haematoma 386.70 11.65 1864 1382908 50331 78309285
Coronary artery occlusion 379.57 11.65 829 1383943 14486 78345130
Subdural haematoma 378.51 11.65 1305 1383467 30129 78329487
Myocardial ischaemia 375.78 11.65 1135 1383637 24384 78335232
Hypotension 372.49 11.65 10146 1374626 430171 77929445
Haemorrhage intracranial 371.71 11.65 1150 1383622 25043 78334573
Completed suicide 370.80 11.65 6163 1378609 239604 78120012
Atrial fibrillation 367.81 11.65 5142 1379630 192744 78166872
Injection site pain 364.25 11.65 1102 1383670 128736 78230880
Anaemia 361.47 11.65 10201 1374571 434814 77924802
Thrombosis in device 349.96 11.65 452 1384320 4990 78354626
Therapeutic product effect incomplete 346.75 11.65 1276 1383496 140369 78219247
Rectal haemorrhage 338.20 11.65 2378 1382394 73922 78285694
Product use issue 336.44 11.65 2196 1382576 207626 78151990
Device expulsion 324.83 11.65 35 1384737 25826 78333790
C-reactive protein abnormal 318.67 11.65 225 1384547 48142 78311474
Haematochezia 317.93 11.65 2606 1382166 85039 78274577
Gastric ulcer 312.35 11.65 1292 1383480 32613 78327003
Blood loss anaemia 310.76 11.65 772 1384000 14726 78344890
Pain 303.59 11.65 9611 1375161 694191 77665425
Condition aggravated 301.57 11.65 6520 1378252 494604 77865012
Haemoglobin decreased 293.81 11.65 5455 1379317 216664 78142952
Acute coronary syndrome 292.64 11.65 920 1383852 20213 78339403
Systemic lupus erythematosus 292.17 11.65 1098 1383674 120051 78239565
Musculoskeletal stiffness 285.43 11.65 1822 1382950 173186 78186430
Hand deformity 281.54 11.65 896 1383876 103023 78256593
Pemphigus 278.71 11.65 846 1383926 98736 78260880
Duodenal ulcer 277.69 11.65 766 1384006 15603 78344013
Bradycardia 274.21 11.65 3577 1381195 131980 78227636
Acute kidney injury 272.89 11.65 11319 1373453 508085 77851531
Joint swelling 269.72 11.65 3463 1381309 285183 78074433
Malignant neoplasm progression 268.88 11.65 1329 1383443 134661 78224955
Disease progression 262.96 11.65 1996 1382776 182366 78177250
Arthropathy 261.44 11.65 1899 1382873 175212 78184404
Epistaxis 258.95 11.65 3020 1381752 108495 78251121
Injection site erythema 257.56 11.65 613 1384159 77584 78282032
Arthralgia 253.70 11.65 7778 1376994 564025 77795591
Angioedema 252.61 11.65 2217 1382555 73818 78285798
Fall 250.50 11.65 10602 1374170 477027 77882589
Glossodynia 246.94 11.65 940 1383832 102397 78257219
Product administration error 245.83 11.65 1151 1383621 30695 78328921
Myelosuppression 243.15 11.65 205 1384567 40091 78319525
Acute hepatic failure 241.79 11.65 1101 1383671 29012 78330604
Therapeutic product effect decreased 239.90 11.65 1761 1383011 162102 78197514
Injection site reaction 237.77 11.65 364 1384408 54421 78305195
Plasma cell myeloma 237.22 11.65 1662 1383110 51597 78308019
Fibromyalgia 237.00 11.65 474 1384298 63866 78295750
Hypoglycaemia 230.42 11.65 2739 1382033 98855 78260761
Neutropenia 229.70 11.65 3562 1381210 284148 78075468
Toxicity to various agents 228.01 11.65 9216 1375556 412324 77947292
International normalised ratio increased 221.61 11.65 2349 1382423 82372 78277244
Faeces discoloured 217.02 11.65 1042 1383730 28085 78331531
Infection 216.19 11.65 2926 1381846 238786 78120830
Exposure to toxic agent 214.87 11.65 485 1384287 8673 78350943
Metabolic acidosis 214.83 11.65 2286 1382486 80243 78279373
Contraindicated product administered 213.71 11.65 1729 1383043 155809 78203807
Loss of personal independence in daily activities 212.37 11.65 986 1383786 101594 78258022
Drug interaction 210.17 11.65 9014 1375758 406169 77953447
Mucosal inflammation 207.28 11.65 648 1384124 74932 78284684
Gastritis erosive 206.70 11.65 530 1384242 10317 78349299
Vascular stent stenosis 202.85 11.65 186 1384586 1341 78358275
Post procedural haemorrhage 202.08 11.65 611 1384161 13133 78346483
Pericarditis 193.98 11.65 1040 1383732 103196 78256420
Gastric ulcer haemorrhage 193.08 11.65 461 1384311 8566 78351050
Swelling 192.46 11.65 2627 1382145 214084 78145532
Product dose omission issue 192.37 11.65 3080 1381692 244457 78115159
Anti-cyclic citrullinated peptide antibody positive 191.80 11.65 767 1384005 82376 78277240
Carotid artery stenosis 187.04 11.65 447 1384325 8311 78351305
Mitral valve incompetence 184.77 11.65 982 1383790 27583 78332033
Abdominal discomfort 184.22 11.65 3152 1381620 247575 78112041
Haemorrhagic stroke 181.55 11.65 511 1384261 10535 78349081
Cerebral infarction 175.33 11.65 1376 1383396 44300 78315316
Ischaemic stroke 174.95 11.65 1079 1383693 32052 78327564
Subarachnoid haemorrhage 171.40 11.65 860 1383912 23605 78336011
Rheumatoid factor positive 171.27 11.65 503 1384269 59336 78300280
Coagulopathy 170.07 11.65 1140 1383632 34866 78324750
Duodenal ulcer haemorrhage 169.90 11.65 381 1384391 6782 78352834
Rheumatic fever 167.39 11.65 149 1384623 28376 78331240
Drug ineffective for unapproved indication 165.30 11.65 406 1384366 50832 78308784
Hypersensitivity 163.80 11.65 3390 1381382 258849 78100767
Shock haemorrhagic 163.70 11.65 737 1384035 19323 78340293
Coronary artery thrombosis 163.35 11.65 234 1384538 2872 78356744
Cytomegalovirus infection 161.52 11.65 309 1384463 42335 78317281
Diverticulum intestinal haemorrhagic 161.45 11.65 267 1384505 3744 78355872
Bone marrow failure 160.95 11.65 410 1384362 50697 78308919
Injection site swelling 160.40 11.65 363 1384409 46769 78312847
Drug resistance 159.78 11.65 306 1384466 41907 78317709
Intraventricular haemorrhage 158.68 11.65 296 1384476 4591 78355025
Dizziness 154.86 11.65 10869 1373903 515572 77844044
Swollen joint count increased 154.55 11.65 104 1384668 22823 78336793
Therapy non-responder 149.89 11.65 962 1383810 91343 78268273
Pyrexia 149.73 11.65 9965 1374807 668744 77690872
Drug hypersensitivity 149.71 11.65 3997 1380775 294919 78064697
Arteriosclerosis coronary artery 147.98 11.65 658 1384114 17158 78342458
Haemorrhagic arteriovenous malformation 146.48 11.65 104 1384668 491 78359125
Injection site pruritus 145.24 11.65 324 1384448 41959 78317657
Vascular graft 143.81 11.65 177 1384595 1854 78357762
Retroperitoneal haematoma 143.12 11.65 297 1384475 5000 78354616
Hospitalisation 142.09 11.65 1004 1383768 93232 78266384
Vascular pseudoaneurysm 141.75 11.65 234 1384538 3276 78356340
Coronary artery restenosis 140.91 11.65 143 1384629 1186 78358430
COVID-19 140.78 11.65 1909 1382863 155765 78203851
Cardiac failure 140.58 11.65 3603 1381169 151239 78208377
Neoplasm progression 140.37 11.65 445 1384327 51237 78308379
Discomfort 139.80 11.65 1449 1383323 124168 78235448
Ischaemic cardiomyopathy 138.45 11.65 368 1384404 7327 78352289
Arteriosclerosis 137.92 11.65 655 1384117 17572 78342044
Stomatitis 133.86 11.65 1769 1383003 144988 78214628
Haematotoxicity 131.95 11.65 52 1384720 15467 78344149
Internal haemorrhage 131.10 11.65 394 1384378 8439 78351177
Neurotoxicity 130.85 11.65 227 1384545 32291 78327325
Hemiplegia 130.37 11.65 560 1384212 14379 78345237
Pericardial haemorrhage 129.71 11.65 259 1384513 4236 78355380
Migraine 129.08 11.65 938 1383834 86555 78273061
Asthenia 126.96 11.65 10424 1374348 501265 77858351
Hemiparesis 126.60 11.65 1011 1383761 32722 78326894
Hyperkalaemia 125.27 11.65 2732 1382040 111666 78247950
Haemorrhagic transformation stroke 124.59 11.65 191 1384581 2501 78357115
Wrong technique in product usage process 124.03 11.65 762 1384010 73113 78286503
Pathogen resistance 122.04 11.65 48 1384724 14294 78345322
Subdural haemorrhage 121.06 11.65 298 1384474 5650 78353966
Therapeutic response decreased 119.98 11.65 675 1384097 66178 78293438
Acute graft versus host disease 119.77 11.65 17 1384755 10150 78349466
Thrombosis 119.71 11.65 2090 1382682 82010 78277606
Suicidal ideation 119.70 11.65 804 1383968 75536 78284080
Presyncope 119.65 11.65 1164 1383608 39890 78319726
Rash 119.40 11.65 8540 1376232 569818 77789798
Drug dependence 117.18 11.65 342 1384430 40427 78319189
Breast cancer stage II 116.07 11.65 6 1384766 8114 78351502
Product prescribing error 115.98 11.65 1240 1383532 43573 78316043
Sinus bradycardia 114.84 11.65 792 1383980 24455 78335161
Product monitoring error 114.49 11.65 378 1384394 8528 78351088
Small intestinal haemorrhage 114.34 11.65 235 1384537 3928 78355688
Post procedural haematoma 114.06 11.65 174 1384598 2268 78357348
Retroperitoneal haemorrhage 113.40 11.65 276 1384496 5194 78354422
Haemoptysis 113.28 11.65 1478 1383294 54521 78305095
Blood creatine phosphokinase increased 112.58 11.65 1692 1383080 64398 78295218
Anion gap 111.32 11.65 162 1384610 2019 78357597
Immune reconstitution inflammatory syndrome 110.30 11.65 51 1384721 13790 78345826
Knee arthroplasty 110.15 11.65 383 1384389 42865 78316751
Graft versus host disease 109.84 11.65 62 1384710 14964 78344652
Deep vein thrombosis postoperative 109.46 11.65 26 1384746 10726 78348890
Hip arthroplasty 109.41 11.65 291 1384481 35465 78324151
Infective pulmonary exacerbation of cystic fibrosis 109.36 11.65 43 1384729 12808 78346808
Therapy partial responder 109.33 11.65 85 1384687 17312 78342304
Extradural haematoma 108.52 11.65 186 1384586 2690 78356926
Pneumocystis jirovecii pneumonia 108.49 11.65 253 1384519 32255 78327361
Blood creatinine increased 108.38 11.65 3491 1381281 151566 78208050
Wound 106.09 11.65 1400 1383372 114779 78244837
Orthostatic hypotension 105.23 11.65 1462 1383310 54702 78304914
Duodenal ulcer perforation 104.47 11.65 696 1384076 65515 78294101
Gastrointestinal vascular malformation haemorrhagic 104.29 11.65 96 1384676 696 78358920
Blood pressure increased 104.07 11.65 4577 1380195 206783 78152833
Spinal epidural haematoma 103.34 11.65 126 1384646 1306 78358310
Grip strength decreased 103.10 11.65 137 1384635 21732 78337884
Posterior reversible encephalopathy syndrome 101.67 11.65 188 1384584 26093 78333523
Multiple-drug resistance 100.84 11.65 16 1384756 8792 78350824
Inflammation 100.43 11.65 1091 1383681 92662 78266954
Haemophagocytic lymphohistiocytosis 99.72 11.65 140 1384632 21697 78337919
Mobility decreased 99.26 11.65 1507 1383265 120668 78238948
Arthritis 99.26 11.65 1400 1383372 113480 78246136
Aspergillus infection 98.80 11.65 112 1384660 19049 78340567
Bronchopulmonary aspergillosis 98.78 11.65 146 1384626 22148 78337468
Neuroleptic malignant syndrome 97.28 11.65 208 1384564 27351 78332265
Myalgia 96.74 11.65 4044 1380728 181597 78178019
Ventricular tachycardia 96.54 11.65 1134 1383638 40801 78318815
Occult blood positive 96.54 11.65 301 1384471 6582 78353034
Dyspnoea 96.04 11.65 16595 1368177 840430 77519186
Heart rate decreased 95.65 11.65 1735 1383037 68581 78291035
Blood pressure fluctuation 94.96 11.65 1667 1383105 65478 78294138
Rheumatoid nodule 94.27 11.65 98 1384674 17340 78342276
Abdominal wall haematoma 93.78 11.65 239 1384533 4634 78354982
Pancytopenia 92.68 11.65 2180 1382592 163565 78196051
C-reactive protein increased 92.44 11.65 1629 1383143 127398 78232218
Breast cancer stage III 92.03 11.65 28 1384744 9798 78349818
Gastritis 91.41 11.65 1253 1383519 46740 78312876
Headache 91.20 11.65 9950 1374822 643822 77715794
Unintentional medical device removal 90.61 11.65 13 1384759 7699 78351917
Post transplant lymphoproliferative disorder 90.19 11.65 43 1384729 11421 78348195
Therapy interrupted 88.56 11.65 265 1384507 31076 78328540
Peripheral arterial occlusive disease 88.45 11.65 330 1384442 7928 78351688
Febrile bone marrow aplasia 87.84 11.65 59 1384713 12961 78346655
Acute myeloid leukaemia 87.37 11.65 261 1384511 30624 78328992
Helicobacter infection 87.29 11.65 781 1383991 68923 78290693
Ecchymosis 87.17 11.65 506 1384266 14700 78344916
Breast cancer stage I 86.93 11.65 8 1384764 6692 78352924
Sleep disorder 86.66 11.65 1010 1383762 84667 78274949
Cytomegalovirus viraemia 86.63 11.65 58 1384714 12763 78346853
Ascites 85.54 11.65 868 1383904 74694 78284922
Venoocclusive liver disease 85.43 11.65 49 1384723 11722 78347894
Intentional self-injury 85.35 11.65 283 1384489 32136 78327480
Premature delivery 85.17 11.65 698 1384074 22769 78336847
Device issue 84.94 11.65 218 1384554 26890 78332726
Device difficult to use 84.62 11.65 65 1384707 13320 78346296
Psoriasis 84.57 11.65 1072 1383700 88515 78271101
Status epilepticus 83.48 11.65 195 1384577 24846 78334770
Incorrect route of product administration 83.24 11.65 318 1384454 34611 78325005
Dyspnoea exertional 83.10 11.65 2040 1382732 85033 78274583
Joint stiffness 82.98 11.65 395 1384377 40435 78319181
Epstein-Barr virus infection 82.56 11.65 77 1384695 14339 78345277
Lacunar infarction 82.16 11.65 259 1384513 5698 78353918
Chronic obstructive pulmonary disease 81.75 11.65 2002 1382770 83417 78276199
Acute graft versus host disease in skin 81.02 11.65 17 1384755 7641 78351975
Facet joint syndrome 80.67 11.65 48 1384724 11254 78348362
Cerebellar haemorrhage 80.39 11.65 165 1384607 2755 78356861
Pregnancy 80.29 11.65 221 1384551 26630 78332986
Asthma 79.72 11.65 1762 1383010 133333 78226283
Hepatic enzyme increased 79.43 11.65 2489 1382283 180121 78179495
Accidental exposure to product 79.35 11.65 278 1384494 31044 78328572
Intentional product use issue 79.23 11.65 2022 1382750 150090 78209526
Heparin-induced thrombocytopenia 79.21 11.65 356 1384416 9326 78350290
Iron deficiency anaemia 78.83 11.65 736 1384036 24936 78334680
Overdose 78.67 11.65 3933 1380839 180273 78179343
Lip dry 78.55 11.65 91 1384681 15327 78344289
Autoimmune disorder 77.37 11.65 105 1384667 16507 78343109
Intermittent claudication 77.21 11.65 180 1384592 3291 78356325
Red blood cell sedimentation rate 76.83 11.65 5 1384767 5560 78354056
Cardiac arrest 76.74 11.65 3690 1381082 168406 78191210
Cardiac disorder 76.03 11.65 1583 1383189 64174 78295442
Dystonia 75.95 11.65 161 1384611 21238 78338378
Septic shock 75.83 11.65 1590 1383182 121211 78238405
Adverse event 75.69 11.65 674 1384098 59540 78300076
Enthesopathy 75.15 11.65 55 1384717 11553 78348063
Haematocrit decreased 74.53 11.65 1487 1383285 59825 78299791
Sinus node dysfunction 74.52 11.65 298 1384474 7403 78352213
Blood urea increased 74.33 11.65 1226 1383546 47564 78312052
Multiple injuries 74.22 11.65 178 1384594 3317 78356299
Diverticulum 74.21 11.65 478 1384294 14418 78345198
Blood pressure decreased 73.85 11.65 2256 1382516 97210 78262406
Illness 73.33 11.65 489 1384283 46022 78313594
Metastases to liver 73.29 11.65 249 1384523 28065 78331551
Heart rate irregular 73.15 11.65 879 1383893 31800 78327816
Foot deformity 72.84 11.65 197 1384575 23877 78335739
Muscle haemorrhage 72.76 11.65 258 1384514 6042 78353574
Lactic acidosis 72.50 11.65 1666 1383106 68693 78290923
Ventricular hypertrophy 72.44 11.65 275 1384497 6663 78352953
Arterial haemorrhage 72.03 11.65 146 1384626 2415 78357201
Graft versus host disease in gastrointestinal tract 71.75 11.65 12 1384760 6344 78353272
Atrioventricular block complete 71.42 11.65 514 1384258 16096 78343520
Joint range of motion decreased 71.19 11.65 316 1384456 32966 78326650
Akathisia 71.13 11.65 75 1384697 13184 78346432
Stent placement 70.21 11.65 261 1384511 6259 78353357
Leukopenia 70.07 11.65 1515 1383257 114998 78244618
Red blood cell sedimentation rate increased 69.96 11.65 488 1384284 45454 78314162
Adverse drug reaction 69.75 11.65 776 1383996 65616 78294000
Graft versus host disease in skin 69.60 11.65 11 1384761 6062 78353554
Duodenitis 68.25 11.65 297 1384475 7670 78351946
Thrombotic microangiopathy 68.09 11.65 156 1384616 20013 78339603
Chronic graft versus host disease 67.86 11.65 17 1384755 6764 78352852
Cardiovascular disorder 67.51 11.65 540 1384232 17485 78342131
Adjustment disorder with depressed mood 67.12 11.65 37 1384735 9049 78350567
Hyperlipidaemia 67.04 11.65 721 1384051 25372 78334244
Device use error 66.93 11.65 20 1384752 7081 78352535
Peripheral ischaemia 66.64 11.65 333 1384439 9124 78350492
Prescribed overdose 66.62 11.65 385 1384387 37498 78322118
Interstitial lung disease 66.60 11.65 1468 1383304 111132 78248484
Prothrombin time prolonged 66.45 11.65 512 1384260 16387 78343229
Diastolic dysfunction 66.09 11.65 366 1384406 10445 78349171
Hepatic necrosis 65.95 11.65 323 1384449 8777 78350839
Dehydration 65.93 11.65 5084 1379688 243103 78116513
Wheezing 65.88 11.65 1532 1383240 115132 78244484
Electrocardiogram abnormal 65.77 11.65 507 1384265 16230 78343386
Folliculitis 65.68 11.65 629 1384143 54751 78304865
Cardiac failure chronic 65.44 11.65 373 1384399 10762 78348854
Ischaemia 65.38 11.65 296 1384476 7779 78351837
Retinitis 65.17 11.65 10 1384762 5633 78353983
Myopathy 64.89 11.65 593 1384179 19970 78339646
Adenovirus infection 64.46 11.65 33 1384739 8414 78351202
Withdrawal syndrome 64.30 11.65 244 1384528 26610 78333006
Systemic infection 64.26 11.65 337 1384435 9415 78350201
Nausea 64.09 11.65 15192 1369580 942004 77417612
Atrioventricular block 63.58 11.65 440 1384332 13601 78346015
Rheumatoid arthritis 63.37 11.65 2965 1381807 205505 78154111
Cardiac tamponade 62.82 11.65 323 1384449 8953 78350663
Drug tolerance decreased 62.52 11.65 80 1384692 12898 78346718
Tricuspid valve incompetence 62.48 11.65 569 1384203 19143 78340473
Large intestinal haemorrhage 61.89 11.65 145 1384627 2660 78356956
Pharyngeal haemorrhage 61.79 11.65 94 1384678 1222 78358394
Hypertensive emergency 61.48 11.65 144 1384628 2641 78356975
Palmar-plantar erythrodysaesthesia syndrome 61.39 11.65 331 1384441 32803 78326813
Sepsis 60.64 11.65 3947 1380825 265481 78094135
Cerebral haematoma 60.52 11.65 286 1384486 7656 78351960
Pulmonary alveolar haemorrhage 60.40 11.65 373 1384399 11084 78348532
Peptic ulcer 60.37 11.65 241 1384531 5982 78353634
Ankylosing spondylitis 60.08 11.65 74 1384698 12131 78347485
Granuloma skin 60.00 11.65 43 1384729 9131 78350485
Injection site warmth 59.91 11.65 103 1384669 14704 78344912
Pallor 59.79 11.65 1211 1383561 48851 78310765
Aortic stenosis 59.39 11.65 273 1384499 7222 78352394
Breast cancer female 59.08 11.65 67 1384705 11394 78348222
Peripheral vascular disorder 58.90 11.65 286 1384486 7744 78351872
Maternal exposure during pregnancy 58.88 11.65 1863 1382909 134675 78224941
Fear of injection 58.85 11.65 28 1384744 7446 78352170
Panniculitis 58.83 11.65 77 1384695 12294 78347322
Electrocardiogram ST segment elevation 58.69 11.65 295 1384477 8102 78351514
Tenosynovitis 58.64 11.65 113 1384659 15441 78344175
Abortion spontaneous 58.49 11.65 288 1384484 29219 78330397
Psychotic disorder 58.13 11.65 450 1384322 40952 78318664
Lung disorder 58.02 11.65 1016 1383756 79541 78280075
Oesophageal carcinoma 58.01 11.65 64 1384708 11020 78348596
Blood parathyroid hormone decreased 57.19 11.65 59 1384713 10477 78349139
Osteoporosis 57.03 11.65 632 1384140 53480 78306136
Oedema peripheral 56.96 11.65 5105 1379667 247183 78112433
Disturbance in social behaviour 56.96 11.65 9 1384763 4961 78354655
Lower limb fracture 56.19 11.65 210 1384562 23005 78336611
Traumatic intracranial haemorrhage 56.17 11.65 87 1384685 1150 78358466
Swollen tongue 56.00 11.65 1045 1383727 41525 78318091
Transplant rejection 55.89 11.65 163 1384609 19274 78340342
Gastrointestinal toxicity 55.72 11.65 36 1384736 8073 78351543
Cytomegalovirus infection reactivation 55.52 11.65 42 1384730 8674 78350942
Microcytic anaemia 55.03 11.65 209 1384563 5065 78354551
Loss of consciousness 54.80 11.65 3499 1381273 164444 78195172
Troponin increased 54.67 11.65 543 1384229 18712 78340904
Colorectal cancer 54.65 11.65 42 1384730 8605 78351011
Haemobilia 54.50 11.65 56 1384716 472 78359144
Puncture site haemorrhage 54.24 11.65 60 1384712 555 78359061
Red blood cell sedimentation rate abnormal 53.82 11.65 185 1384587 20778 78338838
Uterine perforation 53.79 11.65 21 1384751 6282 78353334
Ventricular extrasystoles 53.70 11.65 551 1384221 19153 78340463
Drug reaction with eosinophilia and systemic symptoms 53.69 11.65 788 1383984 63456 78296160
Angiopathy 53.22 11.65 254 1384518 6828 78352788
Blood creatine phosphokinase MB increased 53.20 11.65 137 1384635 2674 78356942
Atrial flutter 53.01 11.65 592 1384180 21033 78338583
Blister 52.78 11.65 1625 1383147 117851 78241765
Percutaneous coronary intervention 52.74 11.65 49 1384723 360 78359256
Human herpesvirus 6 infection 52.71 11.65 14 1384758 5356 78354260
Embolic stroke 52.64 11.65 272 1384500 7554 78352062
Hyperprolactinaemia 52.40 11.65 9 1384763 4667 78354949
Aortic aneurysm 52.34 11.65 287 1384485 8159 78351457
Cerebrovascular disorder 51.94 11.65 162 1384610 3543 78356073
Head injury 51.85 11.65 925 1383847 36444 78323172
Thalamus haemorrhage 51.81 11.65 103 1384669 1679 78357937
Arterial stenosis 51.74 11.65 91 1384681 1345 78358271
Haemothorax 51.43 11.65 210 1384562 5268 78354348
Injection site rash 51.31 11.65 151 1384621 17803 78341813
Neurologic neglect syndrome 51.27 11.65 138 1384634 2769 78356847
Procedural haemorrhage 51.19 11.65 189 1384583 4517 78355099
Bundle branch block left 51.09 11.65 359 1384413 11154 78348462
Transplant dysfunction 51.08 11.65 31 1384741 7190 78352426
Oesophageal intramural haematoma 50.96 11.65 30 1384742 95 78359521
Carotid artery thrombosis 50.92 11.65 142 1384630 2911 78356705
Gastritis haemorrhagic 50.81 11.65 130 1384642 2527 78357089
Cerebral ischaemia 50.80 11.65 351 1384421 10844 78348772
Malaise 50.54 11.65 7599 1377173 482270 77877346
Bone erosion 50.35 11.65 151 1384621 17696 78341920
Lymphopenia 50.34 11.65 317 1384455 30240 78329376
Mood swings 49.99 11.65 177 1384595 19703 78339913
Sinus arrest 49.52 11.65 157 1384615 3465 78356151
Chromaturia 49.36 11.65 673 1384099 25073 78334543
Paradoxical drug reaction 49.23 11.65 32 1384740 7153 78352463
Confusional state 49.10 11.65 6273 1378499 311724 78047892
Tongue haematoma 49.08 11.65 37 1384735 195 78359421
Blood cholesterol increased 49.07 11.65 1093 1383679 82627 78276989
Mania 49.04 11.65 158 1384614 18102 78341514
Chronic kidney disease 48.97 11.65 1500 1383272 64654 78294962
Peptic ulcer haemorrhage 48.82 11.65 72 1384700 909 78358707
Irritable bowel syndrome 48.75 11.65 773 1383999 61468 78298148
Benign prostatic hyperplasia 48.58 11.65 357 1384415 11255 78348361
Seizure 48.53 11.65 2732 1382040 186102 78173514
Diarrhoea 48.39 11.65 14096 1370676 866393 77493223
Osteonecrosis of jaw 48.32 11.65 498 1384274 42728 78316888
Arterial occlusive disease 48.22 11.65 281 1384491 8175 78351441
Gastrointestinal ulcer haemorrhage 47.97 11.65 83 1384689 1210 78358406
Mallory-Weiss syndrome 47.91 11.65 133 1384639 2719 78356897
Hepatitis B reactivation 47.91 11.65 23 1384749 6085 78353531
Hepatic cirrhosis 47.80 11.65 382 1384390 34524 78325092
Arrhythmia 47.71 11.65 1398 1383374 59874 78299742
Vascular graft occlusion 47.65 11.65 61 1384711 667 78358949
Coronary artery aneurysm 47.64 11.65 31 1384741 123 78359493
Ventricular dysfunction 47.44 11.65 219 1384553 5804 78353812
Renal failure 47.43 11.65 4080 1380692 196888 78162728
Virologic failure 47.12 11.65 8 1384764 4183 78355433
Impaired healing 47.02 11.65 1160 1383612 86495 78273121
Ventricular hypokinesia 46.99 11.65 299 1384473 8980 78350636
Aortic valve incompetence 46.98 11.65 305 1384467 9225 78350391
Splenic rupture 46.61 11.65 119 1384653 2310 78357306
Electrocardiogram ST segment depression 46.59 11.65 188 1384584 4690 78354926
Bundle branch block right 46.56 11.65 345 1384427 10906 78348710
Erythema 46.41 11.65 3294 1381478 219996 78139620
Obesity 46.00 11.65 389 1384383 34736 78324880
Bleeding time prolonged 45.93 11.65 81 1384691 1200 78358416
BK virus infection 45.90 11.65 51 1384721 8753 78350863
Peripheral artery stenosis 45.85 11.65 82 1384690 1229 78358387
Cystitis haemorrhagic 45.80 11.65 55 1384717 9117 78350499
Hiatus hernia 45.77 11.65 612 1384160 22700 78336916
High density lipoprotein decreased 45.74 11.65 181 1384591 4474 78355142
Osteoarthritis 45.60 11.65 1160 1383612 86149 78273467
Analgesic drug level increased 45.52 11.65 140 1384632 3038 78356578
Drug tolerance 45.50 11.65 50 1384722 8625 78350991
Second primary malignancy 45.27 11.65 115 1384657 14235 78345381
Vascular stent occlusion 45.27 11.65 36 1384736 208 78359408
Metastases to bone 44.71 11.65 245 1384527 24182 78335434
Coronary artery dissection 44.50 11.65 75 1384697 1069 78358547
Aortic valve stenosis 44.32 11.65 196 1384576 5098 78354518
Mediastinal haematoma 44.28 11.65 34 1384738 185 78359431
Dislocation of vertebra 44.06 11.65 43 1384729 7837 78351779
Candida infection 44.06 11.65 437 1384335 37777 78321839
Gastrointestinal disorder 44.04 11.65 1705 1383067 120500 78239116
Disability 44.01 11.65 151 1384621 16969 78342647
X-ray abnormal 43.93 11.65 23 1384749 5790 78353826
Complication of device insertion 43.89 11.65 28 1384744 6322 78353294
Product storage error 43.85 11.65 140 1384632 16086 78343530
Poisoning deliberate 43.84 11.65 173 1384599 18655 78340961
Aphasia 43.72 11.65 1092 1383680 45640 78313976
Atrioventricular block second degree 43.67 11.65 246 1384526 7066 78352550
Device leakage 43.48 11.65 76 1384696 10780 78348836
Lupus vulgaris 43.40 11.65 4 1384768 3342 78356274
Pneumonia cytomegaloviral 43.33 11.65 16 1384756 4953 78354663
Medication error 43.00 11.65 1526 1383246 67116 78292500
Anti-cyclic citrullinated peptide antibody 42.99 11.65 24 1384748 5828 78353788
Gastrointestinal angiodysplasia 42.81 11.65 71 1384701 998 78358618
Mouth haemorrhage 42.74 11.65 330 1384442 10569 78349047
Haemorrhage urinary tract 42.57 11.65 116 1384656 2345 78357271
Depression 42.49 11.65 3214 1381558 213576 78146040
Metastases to lung 42.22 11.65 167 1384605 17996 78341620
Cytokine release syndrome 42.20 11.65 410 1384362 35588 78324028
Diverticulum intestinal 42.17 11.65 275 1384497 8330 78351286
Basal ganglia haemorrhage 42.03 11.65 91 1384681 1580 78358036
Viral mutation identified 42.00 11.65 8 1384764 3850 78355766
Fungal infection 41.88 11.65 493 1384279 41255 78318361
Intercepted product preparation error 41.83 11.65 6 1384766 3554 78356062
C-reactive protein 41.81 11.65 17 1384755 4962 78354654
Haemorrhagic infarction 41.72 11.65 59 1384713 715 78358901
Metastases to central nervous system 41.71 11.65 145 1384627 16230 78343386
Multiple sclerosis relapse 41.64 11.65 563 1384209 45970 78313646
Ill-defined disorder 41.52 11.65 850 1383922 65025 78294591
Gastrointestinal ulcer 41.42 11.65 143 1384629 3303 78356313
Subcutaneous haematoma 41.34 11.65 124 1384648 2653 78356963
Diffuse large B-cell lymphoma recurrent 41.23 11.65 11 1384761 4196 78355420
Coronary angioplasty 41.19 11.65 43 1384729 370 78359246
Bacterial infection 41.15 11.65 346 1384426 30934 78328682
Injection site urticaria 41.07 11.65 102 1384670 12724 78346892
Serotonin syndrome 40.57 11.65 544 1384228 44483 78315133
Carotid artery disease 40.45 11.65 108 1384664 2156 78357460
Urinary bladder haemorrhage 40.39 11.65 116 1384656 2420 78357196
Hepatojugular reflux 40.39 11.65 53 1384719 595 78359021
Dysarthria 40.32 11.65 1495 1383277 66127 78293489
Haemorrhage subcutaneous 40.23 11.65 178 1384594 4631 78354985
Sickle cell anaemia with crisis 40.09 11.65 47 1384725 7875 78351741
Basilar artery thrombosis 40.04 11.65 41 1384731 344 78359272
Haemorrhagic cerebral infarction 40.04 11.65 83 1384689 1396 78358220
Mucormycosis 39.98 11.65 53 1384719 8416 78351200
Device dislocation 39.96 11.65 275 1384497 25695 78333921
Lymphoproliferative disorder 39.86 11.65 24 1384748 5591 78354025
Large intestine polyp 39.86 11.65 366 1384406 12342 78347274
Full blood count decreased 39.78 11.65 671 1384101 26148 78333468
Glomerular filtration rate decreased 39.74 11.65 584 1384188 22118 78337498
Metastases to lymph nodes 39.66 11.65 75 1384697 10322 78349294
Drug withdrawal syndrome 39.62 11.65 398 1384374 34320 78325296
Weight increased 39.40 11.65 4215 1380557 273171 78086445
Gout 39.22 11.65 626 1384146 24123 78335493
Intentional product misuse 39.18 11.65 2025 1382747 93140 78266476
Potentiating drug interaction 39.13 11.65 275 1384497 8544 78351072
Unintended pregnancy 39.09 11.65 10 1384762 3923 78355693
Breast cancer 39.08 11.65 386 1384386 33395 78326221
Ventricular fibrillation 39.03 11.65 775 1383997 31151 78328465
Blood glucose increased 38.88 11.65 2403 1382369 112572 78247044
Adjustment disorder 38.88 11.65 155 1384617 3845 78355771
Coagulation time abnormal 38.83 11.65 32 1384740 196 78359420
Device related infection 38.78 11.65 394 1384378 33900 78325716
Blood glucose decreased 38.78 11.65 656 1384116 25578 78334038
Platelet dysfunction 38.77 11.65 43 1384729 399 78359217
Spontaneous haematoma 38.73 11.65 80 1384692 1342 78358274
Brain herniation 38.73 11.65 242 1384530 7221 78352395
Renal haemorrhage 38.69 11.65 106 1384666 2150 78357466
Cardiac aneurysm 38.56 11.65 83 1384689 1435 78358181
Amenorrhoea 38.54 11.65 46 1384726 7646 78351970
Coordination abnormal 38.46 11.65 465 1384307 16847 78342769
Electrocardiogram PR prolongation 38.44 11.65 85 1384687 1498 78358118
Inappropriate schedule of product administration 38.33 11.65 1912 1382860 131716 78227900
Cytomegalovirus chorioretinitis 38.23 11.65 24 1384748 5466 78354150
Creatinine renal clearance decreased 38.20 11.65 501 1384271 18501 78341115
Dilatation atrial 38.00 11.65 146 1384626 3558 78356058
Pulmonary oedema 37.99 11.65 1886 1382886 86368 78273248
Urogenital haemorrhage 37.94 11.65 64 1384708 913 78358703
Appendicolith 37.88 11.65 56 1384716 8495 78351121
Colitis microscopic 37.86 11.65 318 1384454 10450 78349166
Diffuse large B-cell lymphoma 37.83 11.65 98 1384674 12051 78347565
Atrioventricular block first degree 37.80 11.65 357 1384415 12134 78347482
Paraesthesia 37.47 11.65 2596 1382176 173727 78185889
Depressed level of consciousness 37.46 11.65 2045 1382727 94607 78265009
Muscular weakness 37.43 11.65 3260 1381512 157469 78202147
No adverse event 37.38 11.65 439 1384333 36753 78322863
Helicobacter test positive 37.30 11.65 76 1384696 1262 78358354
Coronary artery perforation 37.29 11.65 22 1384750 70 78359546
Circulatory collapse 37.28 11.65 887 1383885 36781 78322835
Oesophagitis haemorrhagic 37.13 11.65 52 1384720 624 78358992
Agranulocytosis 37.05 11.65 554 1384218 44476 78315140
Acute graft versus host disease in intestine 36.98 11.65 12 1384760 4029 78355587
Nasopharyngitis 36.97 11.65 3851 1380921 250030 78109586
Sleep disorder due to general medical condition, insomnia type 36.83 11.65 533 1384239 43023 78316593
Strongyloidiasis 36.70 11.65 11 1384761 3887 78355729
Gastrointestinal polyp haemorrhage 36.65 11.65 45 1384727 470 78359146
Low density lipoprotein increased 36.60 11.65 266 1384506 8356 78351260
Cystic fibrosis 36.44 11.65 11 1384761 3869 78355747
Abortion incomplete 36.38 11.65 5 1384767 3059 78356557
Neutrophil count decreased 36.29 11.65 1300 1383472 92659 78266957
Renal cancer 36.28 11.65 101 1384671 12125 78347491
Drug dose omission by device 36.25 11.65 33 1384739 6217 78353399
Carotid arteriosclerosis 36.19 11.65 115 1384657 2541 78357075
Helicobacter gastritis 36.12 11.65 109 1384663 2340 78357276
Oesophageal ulcer 36.09 11.65 226 1384546 6749 78352867
Ventricular arrhythmia 35.97 11.65 270 1384502 8570 78351046
Joint destruction 35.92 11.65 30 1384742 5895 78353721
Spinal cord haemorrhage 35.86 11.65 47 1384725 527 78359089
Erosive duodenitis 35.84 11.65 99 1384673 2018 78357598
Myocardial rupture 35.72 11.65 32 1384740 223 78359393
Hyponatraemia 35.68 11.65 3569 1381203 174279 78185337
Hypogammaglobulinaemia 35.52 11.65 111 1384661 12840 78346776
Bone density decreased 35.49 11.65 116 1384656 13231 78346385
Hypertensive heart disease 35.43 11.65 156 1384616 4050 78355566
Pulmonary tuberculosis 35.34 11.65 51 1384721 7814 78351802
Brain stem infarction 35.30 11.65 95 1384677 1906 78357710
Ulcer haemorrhage 35.26 11.65 197 1384575 5641 78353975
Acute lymphocytic leukaemia recurrent 35.24 11.65 19 1384753 4705 78354911
Traumatic haemorrhage 35.15 11.65 74 1384698 1259 78358357
Cardiac murmur 35.14 11.65 425 1384347 15399 78344217
Leukoencephalopathy 35.06 11.65 52 1384720 7877 78351739
Haemoperitoneum 35.01 11.65 159 1384613 4184 78355432
Aneurysm 34.90 11.65 138 1384634 3410 78356206
Pseudomonas infection 34.87 11.65 216 1384556 20687 78338929
International normalised ratio decreased 34.85 11.65 250 1384522 7820 78351796
Cerebral artery occlusion 34.75 11.65 86 1384686 1636 78357980
Sudden cardiac death 34.73 11.65 181 1384591 5044 78354572
Alanine aminotransferase abnormal 34.68 11.65 63 1384709 8804 78350812
Neutropenic sepsis 34.42 11.65 302 1384470 26762 78332854
Sinusitis 34.36 11.65 2924 1381848 192577 78167039
Toxic anterior segment syndrome 34.06 11.65 4 1384768 2760 78356856
Surgery 34.00 11.65 384 1384388 32382 78327234
Lower respiratory tract infection 33.65 11.65 1867 1382905 127353 78232263
Multiple organ dysfunction syndrome 33.62 11.65 1725 1383047 118521 78241095
Device malfunction 33.55 11.65 226 1384546 21222 78338394
Anxiety 33.47 11.65 3790 1380982 244722 78114894
Exposure during pregnancy 33.44 11.65 1425 1383347 99707 78259909
Tongue oedema 33.40 11.65 225 1384547 6892 78352724
Hypertension 33.40 11.65 6377 1378395 324615 78035001
Oesophageal haemorrhage 33.32 11.65 86 1384686 1681 78357935
Tuberculosis 33.29 11.65 143 1384629 15055 78344561
Chest discomfort 33.26 11.65 2807 1381965 135237 78224379
Epilepsy 33.17 11.65 504 1384268 40356 78319260
Gingival bleeding 33.08 11.65 430 1384342 15846 78343770
Haemarthrosis 33.05 11.65 193 1384579 5619 78353997
Intentional overdose 32.99 11.65 2199 1382573 103761 78255855
Aplasia 32.93 11.65 53 1384719 7767 78351849
Juvenile idiopathic arthritis 32.92 11.65 21 1384751 4742 78354874
Splenic haematoma 32.88 11.65 34 1384738 289 78359327
Peripheral venous disease 32.86 11.65 153 1384619 15756 78343860
Angiocardiogram 32.85 11.65 30 1384742 215 78359401
Activated partial thromboplastin time prolonged 32.85 11.65 385 1384387 13843 78345773
Electrolyte imbalance 32.67 11.65 734 1384038 30147 78329469
Anion gap abnormal 32.60 11.65 48 1384724 605 78359011
Neoplasm malignant 32.54 11.65 374 1384398 31436 78328180
Dermatitis exfoliative generalised 32.49 11.65 47 1384725 7194 78352422
Non-cardiac chest pain 32.29 11.65 279 1384493 9245 78350371
Ovarian cyst 32.27 11.65 112 1384660 12543 78347073
Cardiac valve disease 32.23 11.65 190 1384582 5551 78354065
Renal impairment 32.18 11.65 3170 1381602 154613 78205003
Polycythaemia vera 32.15 11.65 36 1384736 338 78359278
Hypertensive crisis 32.03 11.65 523 1384249 20247 78339369
Aortic aneurysm rupture 31.98 11.65 70 1384702 1225 78358391
Pulmonary fibrosis 31.87 11.65 556 1384216 43556 78316060
Tumour lysis syndrome 31.85 11.65 264 1384508 23675 78335941
Brain stem haemorrhage 31.83 11.65 81 1384691 1569 78358047
Type 2 diabetes mellitus 31.71 11.65 752 1384020 56370 78303246
Blood potassium increased 31.66 11.65 698 1384074 28577 78331039
Subcapsular renal haematoma 31.65 11.65 52 1384720 725 78358891
Brain contusion 31.42 11.65 72 1384700 1301 78358315
Prostate cancer stage I 31.41 11.65 4 1384768 2593 78357023
Haemorrhoidal haemorrhage 31.40 11.65 214 1384558 6581 78353035
Infusion related reaction 31.30 11.65 3509 1381263 226728 78132888
Oral herpes 31.22 11.65 315 1384457 27139 78332477
Vascular device infection 31.16 11.65 84 1384688 10192 78349424
Impaired quality of life 31.12 11.65 136 1384636 14250 78345366
Sleep disorder due to a general medical condition 30.87 11.65 135 1384637 14142 78345474
Acute lung injury 30.83 11.65 121 1384651 2979 78356637
Miosis 30.78 11.65 155 1384617 15634 78343982
Vitreous haemorrhage 30.73 11.65 137 1384635 3576 78356040
Secondary immunodeficiency 30.68 11.65 9 1384763 3225 78356391
Diverticulitis intestinal haemorrhagic 30.55 11.65 40 1384732 448 78359168
Procedural pain 30.52 11.65 255 1384517 22829 78336787
Normochromic normocytic anaemia 30.32 11.65 234 1384538 7493 78352123
Herpes simplex 30.31 11.65 109 1384663 12078 78347538
Cytopenia 30.30 11.65 218 1384554 20165 78339451
Product quality issue 30.23 11.65 411 1384361 33529 78326087
Naevus flammeus 30.22 11.65 19 1384753 70 78359546
Arterial restenosis 30.14 11.65 18 1384754 59 78359557
Haemodialysis 30.11 11.65 463 1384309 17705 78341911
Left ventricular failure 30.08 11.65 276 1384496 9305 78350311
Mycobacterial infection 30.04 11.65 13 1384759 3655 78355961
Orthopnoea 30.03 11.65 287 1384485 9786 78349830
Frequent bowel movements 29.94 11.65 348 1384424 29191 78330425
Platelet function test abnormal 29.93 11.65 26 1384746 173 78359443
Muscle injury 29.89 11.65 629 1384143 47932 78311684
Product dose omission in error 29.87 11.65 56 1384716 7732 78351884
Staphylococcal infection 29.77 11.65 777 1383995 57518 78302098
Reye's syndrome 29.77 11.65 13 1384759 16 78359600
Klebsiella infection 29.70 11.65 156 1384616 15564 78344052
Myositis 29.69 11.65 483 1384289 18685 78340931
Appendicitis 29.67 11.65 225 1384547 20569 78339047
Electrocardiogram T wave inversion 29.65 11.65 177 1384595 5195 78354421
Dementia 29.61 11.65 597 1384175 24062 78335554
Electrocardiogram Q wave abnormal 29.58 11.65 45 1384727 585 78359031
Nodule 29.50 11.65 256 1384516 22738 78336878
Haemorrhagic erosive gastritis 29.48 11.65 49 1384723 690 78358926
Gastrointestinal arteriovenous malformation 29.41 11.65 57 1384715 911 78358705
Sarcoidosis 29.34 11.65 63 1384709 8272 78351344
Injection site bruising 29.24 11.65 518 1384254 40484 78319132
Oropharyngeal pain 29.20 11.65 1576 1383196 107777 78251839
Hyperammonaemia 29.09 11.65 97 1384675 10996 78348620
Hallucination, auditory 29.01 11.65 225 1384547 20468 78339148
Irritability 28.96 11.65 521 1384251 40623 78318993
Thrombotic stroke 28.90 11.65 49 1384723 702 78358914
Accidental overdose 28.90 11.65 896 1383876 38685 78320931
Peripheral coldness 28.81 11.65 413 1384359 15557 78344059
Asthma-chronic obstructive pulmonary disease overlap syndrome 28.72 11.65 10 1384762 3211 78356405
Respiratory tract haemorrhage 28.66 11.65 83 1384689 1740 78357876
Osteonecrosis 28.63 11.65 374 1384398 30721 78328895
Occult blood 28.60 11.65 80 1384692 1643 78357973
Balance disorder 28.57 11.65 2039 1382733 96818 78262798
Diabetic foot 28.56 11.65 132 1384640 3500 78356116
Fat embolism 28.48 11.65 37 1384735 411 78359205
Myelodysplastic syndrome 28.43 11.65 363 1384409 29938 78329678
Deafness transitory 28.31 11.65 57 1384715 938 78358678
Blood pressure inadequately controlled 28.22 11.65 194 1384578 5983 78353633
Renal papillary necrosis 28.10 11.65 36 1384736 394 78359222
Small intestine ulcer 27.79 11.65 47 1384725 672 78358944
Stress 27.75 11.65 1115 1383657 78497 78281119
Rash maculo-papular 27.71 11.65 751 1384021 55327 78304289
Haemorrhagic cholecystitis 27.69 11.65 19 1384753 84 78359532
Pulmonary renal syndrome 27.66 11.65 44 1384728 596 78359020
Lymphadenopathy 27.65 11.65 708 1384064 52539 78307077
Immunodeficiency 27.64 11.65 243 1384529 21525 78338091
Injection site mass 27.58 11.65 221 1384551 19963 78339653
Cardiogenic shock 27.54 11.65 937 1383835 40977 78318639
Varicella zoster virus infection 27.53 11.65 22 1384750 4419 78355197
Labile blood pressure 27.52 11.65 94 1384678 2159 78357457
Cardiomegaly 27.46 11.65 625 1384147 25727 78333889
Periorbital oedema 27.38 11.65 244 1384528 8158 78351458
Lipodystrophy acquired 27.34 11.65 21 1384751 4304 78355312
Immune effector cell-associated neurotoxicity syndrome 27.20 11.65 37 1384735 5811 78353805
Hyphaema 27.19 11.65 53 1384719 851 78358765
Syringe issue 27.17 11.65 42 1384730 6256 78353360
Implant site haematoma 27.05 11.65 23 1384749 148 78359468
Cerebral artery stenosis 26.95 11.65 48 1384724 717 78358899
Urine abnormality 26.94 11.65 239 1384533 7980 78351636
Ejection fraction decreased 26.93 11.65 789 1383983 33788 78325828
Orthostatic intolerance 26.86 11.65 84 1384688 1840 78357776
Anosognosia 26.85 11.65 16 1384756 3748 78355868
Cerebellar infarction 26.82 11.65 130 1384642 3517 78356099
Hyperglycaemia 26.82 11.65 1486 1383286 68849 78290767
Cushingoid 26.82 11.65 81 1384691 9471 78350145
Drug use disorder 26.77 11.65 70 1384702 8581 78351035
Skin toxicity 26.71 11.65 66 1384706 8248 78351368
Galactorrhoea 26.71 11.65 15 1384757 3631 78355985
Total lung capacity increased 26.71 11.65 4 1384768 2294 78357322
Colonic haematoma 26.67 11.65 18 1384754 77 78359539
Acidosis 26.65 11.65 487 1384285 19275 78340341
Blood pH decreased 26.51 11.65 156 1384616 4555 78355061
Vertebral artery stenosis 26.49 11.65 24 1384748 170 78359446
Drug eruption 26.48 11.65 571 1384201 43364 78316252
Lupus-like syndrome 26.46 11.65 137 1384635 13720 78345896
Injury 26.45 11.65 1088 1383684 76408 78283208
HELLP syndrome 26.40 11.65 49 1384723 757 78358859
Injection site induration 26.34 11.65 85 1384687 9734 78349882
Device breakage 26.21 11.65 96 1384676 10579 78349037
Conjunctival haemorrhage 26.09 11.65 183 1384589 5682 78353934
Catheter site haematoma 26.03 11.65 33 1384739 357 78359259
Nocturia 25.97 11.65 357 1384415 13324 78346292
Systemic candida 25.91 11.65 48 1384724 6658 78352958
Silent myocardial infarction 25.78 11.65 46 1384726 688 78358928
Deep vein thrombosis 25.78 11.65 2437 1382335 118482 78241134
Diabetes mellitus inadequate control 25.76 11.65 577 1384195 23687 78335929
Complication of device removal 25.73 11.65 18 1384754 3871 78355745
Scrotal haematoma 25.66 11.65 17 1384755 70 78359546
Cerebral hyperperfusion syndrome 25.62 11.65 20 1384752 112 78359504
Dry mouth 25.51 11.65 1258 1383514 86761 78272855
Cerebral mass effect 25.49 11.65 82 1384690 1824 78357792
Labile hypertension 25.48 11.65 39 1384733 510 78359106
Left ventricular hypertrophy 25.48 11.65 302 1384470 10889 78348727
Antipsychotic drug level increased 25.44 11.65 40 1384732 5917 78353699
Glycosylated haemoglobin increased 25.40 11.65 473 1384299 18787 78340829
Blood urine present 25.37 11.65 515 1384257 20782 78338834
Pyroglutamic acidosis 25.26 11.65 57 1384715 1019 78358597
Bacteraemia 25.25 11.65 409 1384363 32415 78327201
Affective disorder 25.23 11.65 68 1384704 8251 78351365
Aortic valve sclerosis 25.11 11.65 78 1384694 1702 78357914
Cerebral microhaemorrhage 25.05 11.65 26 1384746 222 78359394
Adrenal insufficiency 25.00 11.65 346 1384426 28141 78331475
Intestinal haemorrhage 24.88 11.65 194 1384578 6232 78353384
Bursitis 24.88 11.65 455 1384317 35389 78324227
Pyroglutamate increased 24.80 11.65 44 1384728 655 78358961
Angioplasty 24.78 11.65 80 1384692 1783 78357833
Blood prolactin increased 24.70 11.65 20 1384752 3991 78355625
Hypochromic anaemia 24.68 11.65 104 1384668 2647 78356969
Vessel puncture site haematoma 24.68 11.65 24 1384748 188 78359428
Oesophagitis 24.66 11.65 574 1384198 23715 78335901
Small intestinal ulcer haemorrhage 24.66 11.65 19 1384753 104 78359512
Hepatitis B 24.60 11.65 69 1384703 8263 78351353
Choroidal haemorrhage 24.59 11.65 22 1384750 153 78359463
Unresponsive to stimuli 24.59 11.65 1195 1383577 54593 78305023
Bradyarrhythmia 24.44 11.65 139 1384633 4007 78355609
Lymphoma 24.40 11.65 190 1384582 17270 78342346
Venoocclusive disease 24.38 11.65 26 1384746 4547 78355069
Prostate cancer stage IV 24.26 11.65 6 1384766 2408 78357208
Type V hyperlipidaemia 24.21 11.65 55 1384717 988 78358628
Intra-abdominal haematoma 24.18 11.65 107 1384665 2784 78356832
Essential hypertension 24.14 11.65 184 1384588 5869 78353747
Computerised tomogram coronary artery abnormal 24.11 11.65 24 1384748 194 78359422
Spinal cord haematoma 24.11 11.65 29 1384743 296 78359320
Oesophageal mucosal dissection 24.08 11.65 12 1384760 24 78359592
Pregnancy with contraceptive device 24.06 11.65 17 1384755 3637 78355979
Pelvic pain 24.06 11.65 135 1384637 13246 78346370
Personality disorder 24.05 11.65 186 1384586 5960 78353656
Abortion early 23.95 11.65 10 1384762 10 78359606
Alcohol abuse 23.88 11.65 35 1384737 5328 78354288
Eye haemorrhage 23.87 11.65 267 1384505 9490 78350126
Mental status changes 23.86 11.65 1406 1383366 65553 78294063
Idiopathic pulmonary fibrosis 23.78 11.65 140 1384632 4088 78355528
Drug specific antibody 23.71 11.65 8 1384764 2620 78356996
Blood pressure diastolic decreased 23.68 11.65 690 1384082 29526 78330090
Carotid bruit 23.66 11.65 46 1384726 737 78358879
Cerebral thrombosis 23.61 11.65 93 1384679 2294 78357322
Sciatica 23.60 11.65 420 1384352 32802 78326814
Uveitis 23.59 11.65 183 1384589 16647 78342969
Wound haemorrhage 23.55 11.65 138 1384634 4023 78355593
Basilar artery stenosis 23.55 11.65 13 1384759 35 78359581
Post procedural complication 23.54 11.65 561 1384211 23268 78336348
Aggression 23.50 11.65 689 1384083 50269 78309347
Cardiac ventricular thrombosis 23.46 11.65 76 1384696 1697 78357919
Nocardiosis 23.44 11.65 39 1384733 5640 78353976
Skin necrosis 23.37 11.65 201 1384571 17886 78341730
Liver function test increased 23.37 11.65 519 1384253 39254 78320362
Bladder tamponade 23.28 11.65 39 1384733 553 78359063
Obsessive-compulsive disorder 23.28 11.65 42 1384730 5885 78353731
Acne 23.24 11.65 332 1384440 26858 78332758
Hypovolaemic shock 23.17 11.65 320 1384452 11956 78347660
Electrocardiogram T wave abnormal 23.15 11.65 127 1384645 3611 78356005
Hepatocellular injury 23.09 11.65 639 1384133 46954 78312662
Gastroduodenal haemorrhage 23.08 11.65 27 1384745 267 78359349
Sleep terror 23.05 11.65 26 1384746 4432 78355184
Exercise tolerance decreased 23.00 11.65 250 1384522 8821 78350795
Mycobacterium chelonae infection 23 11.65 7 1384765 2449 78357167
Gastric mucosal lesion 22.95 11.65 51 1384721 902 78358714
Arteriovenous malformation 22.87 11.65 75 1384697 1686 78357930
Stenosis 22.86 11.65 93 1384679 2329 78357287
Obliterative bronchiolitis 22.85 11.65 12 1384760 3016 78356600
Behaviour disorder 22.82 11.65 47 1384725 6266 78353350
Rheumatoid lung 22.78 11.65 24 1384748 4221 78355395
Coronary artery insufficiency 22.75 11.65 22 1384750 171 78359445
Progressive multifocal leukoencephalopathy 22.75 11.65 238 1384534 20362 78339254
Nail disorder 22.73 11.65 117 1384655 11735 78347881
Hepatotoxicity 22.64 11.65 1100 1383672 50252 78309364
Retinal artery occlusion 22.51 11.65 115 1384657 3179 78356437
Tongue disorder 22.49 11.65 146 1384626 13829 78345787
Labelled drug-disease interaction medication error 22.49 11.65 28 1384744 297 78359319
Vertigo 22.46 11.65 1439 1383333 67643 78291973
Infection reactivation 22.43 11.65 9 1384763 2648 78356968
Mood altered 22.32 11.65 200 1384572 17647 78341969
Thrombotic thrombocytopenic purpura 22.26 11.65 188 1384584 6188 78353428
Platelet aggregation inhibition 22.26 11.65 20 1384752 140 78359476
Herpes zoster 22.23 11.65 1356 1383416 91727 78267889
Insurance issue 22.18 11.65 41 1384731 5692 78353924
Metastases to peritoneum 22.06 11.65 26 1384746 4346 78355270
Schizophrenia 22.06 11.65 167 1384605 15273 78344343
Ocular retrobulbar haemorrhage 22.04 11.65 20 1384752 142 78359474
Pneumatosis intestinalis 21.98 11.65 49 1384723 6348 78353268
Chronic gastrointestinal bleeding 21.98 11.65 34 1384738 449 78359167
Generalised tonic-clonic seizure 21.97 11.65 587 1384185 43323 78316293
Thinking abnormal 21.95 11.65 136 1384636 13025 78346591
Dermatitis acneiform 21.91 11.65 94 1384678 9899 78349717
Respiratory alkalosis 21.88 11.65 139 1384633 4172 78355444
Oculogyric crisis 21.84 11.65 12 1384760 2940 78356676
Pulmonary toxicity 21.77 11.65 133 1384639 12781 78346835
Fusarium infection 21.73 11.65 3 1384769 1829 78357787
Subclavian steal syndrome 21.68 11.65 13 1384759 43 78359573
Peripheral artery occlusion 21.66 11.65 95 1384677 2462 78357154
Retinal haemorrhage 21.55 11.65 228 1384544 7989 78351627
Intracardiac thrombus 21.53 11.65 138 1384634 4155 78355461
Hyperammonaemic encephalopathy 21.50 11.65 31 1384741 4751 78354865
Intracranial aneurysm 21.45 11.65 144 1384628 4406 78355210
Inguinal hernia 21.44 11.65 189 1384583 6299 78353317
Device interaction 21.38 11.65 43 1384729 707 78358909
Anaphylactic shock 21.36 11.65 469 1384303 35527 78324089
Foetal growth restriction 21.31 11.65 83 1384689 2036 78357580
Haematoma muscle 21.28 11.65 96 1384676 2519 78357097
Pulmonary haematoma 21.27 11.65 18 1384754 115 78359501
Philadelphia positive acute lymphocytic leukaemia 21.25 11.65 14 1384758 57 78359559
Blindness transient 21.23 11.65 149 1384623 4627 78354989
Respiratory rate increased 21.18 11.65 508 1384264 21092 78338524
Basal ganglia infarction 21.14 11.65 38 1384734 572 78359044
Underdose 21.11 11.65 427 1384345 32724 78326892
Extraocular muscle disorder 21.11 11.65 27 1384745 295 78359321
Acute graft versus host disease in liver 21.09 11.65 4 1384768 1931 78357685
Device deployment issue 21.08 11.65 15 1384757 3197 78356419
Infective exacerbation of chronic obstructive airways disease 21.03 11.65 100 1384672 2684 78356932
Arterial intramural haematoma 20.94 11.65 15 1384757 72 78359544
Extravasation blood 20.93 11.65 31 1384741 393 78359223
Laryngitis 20.83 11.65 178 1384594 15861 78343755
JC virus infection 20.77 11.65 22 1384750 3859 78355757
Coronary artery surgery 20.71 11.65 21 1384751 174 78359442
Somnolence 20.70 11.65 3743 1381029 235238 78124378
Eosinophilia 20.69 11.65 614 1384158 44731 78314885
Acute myeloid leukaemia recurrent 20.67 11.65 17 1384755 3366 78356250
Traumatic haematoma 20.62 11.65 81 1384691 1995 78357621
Seronegative arthritis 20.52 11.65 31 1384741 4661 78354955
Electric shock 20.52 11.65 62 1384710 1332 78358284
Rectal polyp 20.51 11.65 70 1384702 1607 78358009
Fistula 20.42 11.65 136 1384636 12804 78346812
Mouth ulceration 20.34 11.65 509 1384263 37885 78321731
Dry eye 20.27 11.65 487 1384285 36444 78323172
Aortic intramural haematoma 20.21 11.65 19 1384753 142 78359474
Paresis 20.17 11.65 135 1384637 4126 78355490
Epstein-Barr virus associated lymphoproliferative disorder 20.07 11.65 19 1384753 3513 78356103
Nasal disorder 20.05 11.65 123 1384649 3646 78355970
Periorbital haematoma 20.04 11.65 49 1384723 925 78358691
Aortic arteriosclerosis 20.01 11.65 240 1384532 8678 78350938
Cardiac stress test abnormal 19.95 11.65 44 1384728 774 78358842
Unevaluable event 19.91 11.65 776 1383996 54809 78304807
Arterial spasm 19.91 11.65 19 1384753 145 78359471
Platelet aggregation test 19.90 11.65 13 1384759 52 78359564
Pharyngeal haematoma 19.82 11.65 18 1384754 128 78359488
Drug effective for unapproved indication 19.79 11.65 47 1384725 5954 78353662
Atheroembolism 19.70 11.65 27 1384745 317 78359299
Sinus rhythm 19.64 11.65 45 1384727 813 78358803
Coeliac disease 19.61 11.65 116 1384656 11235 78348381
Incision site haemorrhage 19.60 11.65 52 1384720 1034 78358582
Facial paralysis 19.59 11.65 492 1384280 20580 78339036
Diabetic retinopathy 19.56 11.65 106 1384666 3000 78356616
Cerebral amyloid angiopathy 19.52 11.65 27 1384745 320 78359296
Leukaemia recurrent 19.49 11.65 12 1384760 2762 78356854
Coronary artery reocclusion 19.42 11.65 19 1384753 150 78359466
Endometriosis 19.40 11.65 21 1384751 3647 78355969
Mitral valve calcification 19.37 11.65 63 1384709 1410 78358206
Mitral valve thickening 19.35 11.65 30 1384742 397 78359219
Intestinal diaphragm disease 19.34 11.65 27 1384745 323 78359293
Blood calcium decreased 19.34 11.65 705 1384067 31114 78328502
Stent-graft endoleak 19.34 11.65 11 1384761 32 78359584
Colitis 19.29 11.65 1058 1383714 72249 78287367
Euphoric mood 19.28 11.65 69 1384703 7657 78351959
Atrial thrombosis 19.25 11.65 119 1384653 3537 78356079
Intra-abdominal haemorrhage 19.23 11.65 140 1384632 4400 78355216
Memory impairment 19.20 11.65 1674 1383098 110060 78249556
Inferior vena cava dilatation 19.19 11.65 45 1384727 826 78358790
Blepharospasm 19.15 11.65 46 1384726 5805 78353811
Gangrene 19.14 11.65 239 1384533 8725 78350891
Mental disorder 19.10 11.65 406 1384366 30896 78328720
Rebound effect 19.07 11.65 63 1384709 7163 78352453
Intracranial haematoma 19.03 11.65 47 1384725 893 78358723
Incision site haematoma 19.00 11.65 18 1384754 136 78359480
Arthrodesis 18.98 11.65 9 1384763 2398 78357218
Sexual dysfunction 18.93 11.65 70 1384702 7693 78351923
Eyelid haematoma 18.93 11.65 12 1384760 45 78359571
Pulmonary haemorrhage 18.92 11.65 360 1384412 14357 78345259
Ventricle rupture 18.82 11.65 15 1384757 87 78359529
Blood sodium decreased 18.82 11.65 731 1384041 32524 78327092
Catatonia 18.81 11.65 83 1384689 8673 78350943
Wound infection 18.77 11.65 298 1384474 23693 78335923
Joint effusion 18.74 11.65 211 1384561 17803 78341813
Hepatic ischaemia 18.74 11.65 52 1384720 1063 78358553
Paronychia 18.66 11.65 71 1384701 7737 78351879
Cardiotoxicity 18.63 11.65 130 1384642 12109 78347507
Pain in jaw 18.63 11.65 635 1384137 45516 78314100
Pneumonia fungal 18.61 11.65 116 1384656 11094 78348522
Vascular procedure complication 18.61 11.65 10 1384762 25 78359591
Blood pressure systolic increased 18.56 11.65 1377 1383395 65609 78294007
Exostosis 18.52 11.65 195 1384577 16663 78342953
Psychotic symptom 18.49 11.65 12 1384760 2685 78356931
Metabolic disorder 18.46 11.65 89 1384683 9081 78350535
Liver injury 18.44 11.65 799 1383973 55815 78303801
Insomnia 18.43 11.65 3868 1380904 241302 78118314
Depressive symptom 18.37 11.65 54 1384718 6369 78353247
Compartment syndrome 18.36 11.65 151 1384621 4931 78354685
Dermatitis atopic 18.33 11.65 101 1384671 9955 78349661
Deformity 18.32 11.65 95 1384677 9510 78350106
Haemorrhagic ascites 18.32 11.65 24 1384748 269 78359347
QRS axis abnormal 18.29 11.65 78 1384694 1996 78357620
Road traffic accident 18.28 11.65 598 1384174 43066 78316550
Gait inability 18.27 11.65 836 1383936 58081 78301535
Erectile dysfunction 18.27 11.65 357 1384415 14307 78345309
Skin haemorrhage 18.22 11.65 301 1384471 11680 78347936
Wrong technique in device usage process 18.22 11.65 26 1384746 4002 78355614
Granuloma 18.22 11.65 78 1384694 8219 78351397
Page kidney 18.21 11.65 13 1384759 62 78359554
Subclavian artery stenosis 18.19 11.65 22 1384750 226 78359390
Thalamic infarction 18.19 11.65 57 1384715 1250 78358366
Joint dislocation 18.18 11.65 197 1384575 16742 78342874
Incorrect dose administered by device 18.16 11.65 37 1384735 4952 78354664
Troponin T increased 18.15 11.65 114 1384658 3408 78356208
Social avoidant behaviour 18.12 11.65 35 1384737 4779 78354837
Kounis syndrome 18.12 11.65 132 1384640 4150 78355466
Peripheral artery thrombosis 18.11 11.65 113 1384659 3370 78356246
Kidney transplant rejection 18.08 11.65 104 1384668 10142 78349474
Ocular icterus 18.06 11.65 160 1384612 5340 78354276
Prostate cancer stage II 18.05 11.65 8 1384764 2218 78357398
Disease recurrence 18.01 11.65 606 1384166 43503 78316113
Peripheral swelling 18.01 11.65 4278 1380494 265339 78094277
Coronary revascularisation 18.00 11.65 11 1384761 38 78359578
Leriche syndrome 18.00 11.65 11 1384761 38 78359578
Haemorrhagic diathesis 17.97 11.65 173 1384599 5911 78353705
Liver function test abnormal 17.97 11.65 1326 1383446 63149 78296467
Aortic valve disease 17.90 11.65 74 1384698 1867 78357749
Hernia 17.90 11.65 405 1384367 16654 78342962
Anticoagulation drug level below therapeutic 17.89 11.65 63 1384709 1470 78358146
Increased tendency to bruise 17.85 11.65 268 1384504 10196 78349420
Prinzmetal angina 17.81 11.65 68 1384704 1652 78357964
Post procedural myocardial infarction 17.80 11.65 11 1384761 39 78359577
Viral load increased 17.78 11.65 15 1384757 2933 78356683
Low density lipoprotein abnormal 17.73 11.65 30 1384742 429 78359187
Immune-mediated myositis 17.73 11.65 112 1384660 3355 78356261
Urine albumin/creatinine ratio increased 17.73 11.65 34 1384738 539 78359077
Breast cancer stage IV 17.68 11.65 6 1384766 1958 78357658
Dilatation ventricular 17.68 11.65 128 1384644 4016 78355600
Meningitis cryptococcal 17.53 11.65 21 1384751 3485 78356131
Psychiatric decompensation 17.51 11.65 26 1384746 3937 78355679
Renal artery stenosis 17.51 11.65 112 1384660 3370 78356246
Supraventricular extrasystoles 17.46 11.65 192 1384580 6795 78352821
Necrotising myositis 17.37 11.65 55 1384717 1213 78358403
Hip fracture 17.36 11.65 676 1384096 30085 78329531
Crystal urine present 17.35 11.65 79 1384693 2081 78357535
Venous pressure jugular increased 17.34 11.65 57 1384715 1283 78358333
Metal poisoning 17.33 11.65 14 1384758 83 78359533
Obstructive shock 17.33 11.65 14 1384758 83 78359533
Myocardial necrosis marker increased 17.31 11.65 106 1384666 3140 78356476
Supraventricular tachycardia 17.30 11.65 488 1384284 20782 78338834
Enterococcal infection 17.26 11.65 181 1384591 15479 78344137
Transplant failure 17.25 11.65 34 1384738 4607 78355009
Erosive oesophagitis 17.24 11.65 97 1384675 2785 78356831
Vascular pseudoaneurysm ruptured 17.23 11.65 18 1384754 155 78359461
Cataract 17.21 11.65 1277 1383495 60843 78298773
Myocardial haemorrhage 17.21 11.65 11 1384761 42 78359574
Vascular access site haemorrhage 17.21 11.65 11 1384761 42 78359574
Spinal subdural haematoma 17.20 11.65 21 1384751 218 78359398
Vertebrobasilar insufficiency 17.20 11.65 24 1384748 287 78359329
Ageusia 17.18 11.65 394 1384378 16238 78343378
Chronic sinusitis 17.17 11.65 144 1384628 12882 78346734
Product preparation error 17.08 11.65 48 1384724 5745 78353871
Brain death 17.05 11.65 162 1384610 5515 78354101
Mitral valve stenosis 17.05 11.65 53 1384719 1157 78358459
Blue toe syndrome 16.99 11.65 34 1384738 557 78359059
ECG signs of myocardial ischaemia 16.98 11.65 26 1384746 340 78359276
Degenerative mitral valve disease 16.96 11.65 24 1384748 291 78359325
Ankle arthroplasty 16.95 11.65 3 1384769 1522 78358094
Arterial disorder 16.91 11.65 74 1384698 1916 78357700
Colitis ischaemic 16.86 11.65 367 1384405 14992 78344624
Cholestasis 16.85 11.65 736 1384036 51373 78308243
Arterial stent insertion 16.84 11.65 14 1384758 87 78359529
Coronary ostial stenosis 16.81 11.65 18 1384754 160 78359456
Palmoplantar keratoderma 16.79 11.65 24 1384748 3692 78355924
Suicide attempt 16.79 11.65 1226 1383546 81706 78277910
Otitis media staphylococcal 16.76 11.65 7 1384765 7 78359609
Spontaneous haemorrhage 16.70 11.65 41 1384731 776 78358840
Skin flap necrosis 16.69 11.65 10 1384762 33 78359583
Ear haemorrhage 16.67 11.65 78 1384694 2079 78357537
Intestinal haematoma 16.64 11.65 20 1384752 204 78359412
Periorbital haemorrhage 16.64 11.65 22 1384750 249 78359367
Hypothermia 16.63 11.65 515 1384257 22231 78337385
Neutrophil count increased 16.59 11.65 386 1384386 29010 78330606
Hypoaesthesia 16.58 11.65 2799 1381973 176553 78183063
Drop attacks 16.55 11.65 48 1384724 1007 78358609
Aneurysm ruptured 16.54 11.65 45 1384727 909 78358707
Lethargy 16.53 11.65 1633 1383139 79659 78279957
Carcinogenicity 16.49 11.65 13 1384759 74 78359542
Ventricular asystole 16.48 11.65 23 1384749 275 78359341
Craniocerebral injury 16.47 11.65 150 1384622 5046 78354570
Infarction 16.47 11.65 136 1384636 4446 78355170
Spinal operation 16.43 11.65 76 1384696 7841 78351775
Vomiting 16.42 11.65 10954 1373818 654874 77704742
Gastric ulcer perforation 16.35 11.65 77 1384695 2058 78357558
Coagulation time prolonged 16.29 11.65 86 1384686 2409 78357207
Medical device site thrombosis 16.27 11.65 10 1384762 35 78359581
Cardiospasm 16.26 11.65 20 1384752 3281 78356335
Cholecystitis acute 16.26 11.65 326 1384446 13125 78346491
Tardive dyskinesia 16.23 11.65 112 1384660 10459 78349157
Cerebral arteriosclerosis 16.23 11.65 40 1384732 759 78358857
Aortic valve replacement 16.18 11.65 55 1384717 1260 78358356
Pancreatic carcinoma stage IV 16.17 11.65 9 1384763 2189 78357427
Femoral artery aneurysm 16.16 11.65 19 1384753 189 78359427
Myxoedema coma 16.15 11.65 38 1384734 699 78358917
Hypovolaemia 16.13 11.65 412 1384360 17279 78342337
Tonsillitis 16.08 11.65 61 1384711 6653 78352963
Abnormal loss of weight 16.08 11.65 219 1384553 8157 78351459
Vascular graft complication 16.05 11.65 17 1384755 149 78359467
Lip haematoma 16.04 11.65 6 1384766 3 78359613
Musculoskeletal toxicity 16.01 11.65 19 1384753 191 78359425
Traumatic liver injury 15.97 11.65 35 1384737 613 78359003
Pneumocystis jirovecii infection 15.94 11.65 16 1384756 2878 78356738
Barrett's oesophagus 15.90 11.65 40 1384732 769 78358847
Essential thrombocythaemia 15.88 11.65 17 1384755 151 78359465
Gestational diabetes 15.84 11.65 56 1384716 6237 78353379
Osteolysis 15.83 11.65 34 1384738 4464 78355152
Brain stem ischaemia 15.78 11.65 23 1384749 287 78359329
Dysuria 15.78 11.65 1057 1383715 49894 78309722
Gastric ulcer helicobacter 15.75 11.65 8 1384764 17 78359599
Polyomavirus viraemia 15.74 11.65 5 1384767 1702 78357914
Pituitary haemorrhage 15.73 11.65 23 1384749 288 78359328
Gallbladder rupture 15.72 11.65 45 1384727 937 78358679
Dizziness postural 15.71 11.65 285 1384487 11264 78348352
Colitis ulcerative 15.71 11.65 471 1384301 34271 78325345
Ejection fraction 15.69 11.65 10 1384762 2259 78357357
Petechiae 15.67 11.65 468 1384304 20097 78339519
Live birth 15.63 11.65 230 1384542 18514 78341102
Ischaemic cerebral infarction 15.62 11.65 86 1384686 2449 78357167
Microalbuminuria 15.61 11.65 43 1384729 875 78358741
Anti factor VIII antibody positive 15.61 11.65 13 1384759 81 78359535
Carotid artery occlusion 15.53 11.65 202 1384570 7445 78352171
Hemiataxia 15.49 11.65 10 1384762 39 78359577
Left-to-right cardiac shunt 15.47 11.65 14 1384758 99 78359517
Tachypnoea 15.46 11.65 693 1384079 31370 78328246
Haemorrhage coronary artery 15.46 11.65 7 1384765 10 78359606
Embedded device 15.43 11.65 21 1384751 3298 78356318
Congenital hiatus hernia 15.43 11.65 40 1384732 784 78358832
Hyperreflexia 15.40 11.65 84 1384688 8301 78351315
Idiopathic intracranial hypertension 15.38 11.65 20 1384752 3202 78356414
Post procedural stroke 15.37 11.65 14 1384758 100 78359516
Genitourinary tract neoplasm 15.35 11.65 5 1384767 0 78359616
Gravitational oedema 15.33 11.65 68 1384704 1771 78357845
Encephalitis 15.31 11.65 173 1384599 14587 78345029
Lupus vasculitis 15.29 11.65 32 1384740 542 78359074
Functional gastrointestinal disorder 15.29 11.65 143 1384629 4847 78354769
Hyperbilirubinaemia 15.26 11.65 317 1384455 24201 78335415
Subchorionic haematoma 15.16 11.65 14 1384758 102 78359514
Polyarthritis 15.15 11.65 137 1384635 12065 78347551
Duodenitis haemorrhagic 15.13 11.65 16 1384756 140 78359476
Cerebral ventricular rupture 15.11 11.65 28 1384744 432 78359184
Precancerous skin lesion 15.09 11.65 55 1384717 1306 78358310
Bladder neoplasm 15.07 11.65 65 1384707 1672 78357944
Product substitution issue 15.05 11.65 254 1384518 20002 78339614
Hypofibrinogenaemia 15.01 11.65 8 1384764 1994 78357622
Mediastinal haemorrhage 15.00 11.65 12 1384760 70 78359546
Myoglobinaemia 15.00 11.65 15 1384757 122 78359494
Left atrial dilatation 14.99 11.65 100 1384672 3053 78356563
Large intestinal ulcer 14.96 11.65 138 1384634 4659 78354957
Systolic dysfunction 14.93 11.65 115 1384657 3680 78355936
Foetal exposure during pregnancy 14.93 11.65 51 1384721 5739 78353877
Blood creatine increased 14.92 11.65 239 1384533 9216 78350400
Oesophageal ulcer haemorrhage 14.91 11.65 33 1384739 582 78359034
Faeces pale 14.90 11.65 95 1384677 2855 78356761
Portal hypertension 14.89 11.65 68 1384704 7040 78352576
Injection site inflammation 14.89 11.65 29 1384743 3947 78355669
Hypoglycaemic coma 14.88 11.65 137 1384635 4623 78354993
Hypokinesia 14.86 11.65 435 1384337 18625 78340991
Angiogram 14.85 11.65 14 1384758 105 78359511
Trifascicular block 14.84 11.65 17 1384755 164 78359452
Mycotic allergy 14.83 11.65 4 1384768 1515 78358101
Hypertensive nephropathy 14.83 11.65 45 1384727 969 78358647
Anastomotic haemorrhage 14.82 11.65 21 1384751 255 78359361
Leukocyturia 14.81 11.65 71 1384701 1912 78357704
Gastrointestinal tract mucosal pigmentation 14.80 11.65 46 1384726 1004 78358612
Blood lactic acid increased 14.79 11.65 307 1384465 12437 78347179
Synovial cyst 14.79 11.65 108 1384664 9957 78349659
Anion gap increased 14.79 11.65 113 1384659 3607 78356009
Vascular occlusion 14.73 11.65 59 1384713 1467 78358149
Nonreassuring foetal heart rate pattern 14.71 11.65 7 1384765 12 78359604
Gastric cancer stage IV 14.70 11.65 4 1384768 1506 78358110
Dementia Alzheimer's type 14.70 11.65 45 1384727 974 78358642
Dyspnoea paroxysmal nocturnal 14.68 11.65 77 1384695 2151 78357465
Neutrophil percentage increased 14.68 11.65 135 1384637 4554 78355062
Bronchiectasis 14.66 11.65 287 1384485 22099 78337517
Cold sweat 14.65 11.65 427 1384345 18272 78341344
Anuria 14.63 11.65 472 1384300 20491 78339125
Haemodilution 14.63 11.65 16 1384756 146 78359470
Gene mutation 14.63 11.65 15 1384757 2671 78356945
Haemorrhoids 14.58 11.65 632 1384140 28496 78331120
Cardiac valve replacement complication 14.56 11.65 19 1384753 212 78359404
Body tinea 14.51 11.65 7 1384765 1847 78357769
Hypocoagulable state 14.50 11.65 75 1384697 2084 78357532
Tuberculin test positive 14.44 11.65 23 1384749 3385 78356231
Myoglobin blood increased 14.42 11.65 99 1384673 3052 78356564
Depression suicidal 14.41 11.65 28 1384744 3814 78355802
Systemic mycosis 14.39 11.65 15 1384757 2651 78356965
Small intestine polyp 14.37 11.65 8 1384764 22 78359594
Blood immunoglobulin E increased 14.37 11.65 53 1384719 5829 78353787
Otitis media bacterial 14.37 11.65 6 1384766 6 78359610
Tracheal haemorrhage 14.37 11.65 34 1384738 628 78358988
Contrast encephalopathy 14.32 11.65 17 1384755 171 78359445
Arteriospasm coronary 14.31 11.65 179 1384593 6537 78353079
Graft thrombosis 14.29 11.65 27 1384745 423 78359193
Aortic bypass 14.28 11.65 10 1384762 46 78359570
Choroidal dystrophy 14.28 11.65 10 1384762 46 78359570
Heart valve incompetence 14.24 11.65 102 1384670 3189 78356427
Growth retardation 14.23 11.65 8 1384764 1935 78357681
Platelet aggregation increased 14.17 11.65 14 1384758 112 78359504
Androgenetic alopecia 14.15 11.65 16 1384756 152 78359464
Umbilical haemorrhage 14.13 11.65 8 1384764 23 78359593
Immunosuppression 14.10 11.65 148 1384624 12655 78346961
Eructation 14.07 11.65 267 1384505 10642 78348974
Oral candidiasis 14.06 11.65 399 1384373 29229 78330387
Cardiac operation 14.06 11.65 141 1384631 4871 78354745
Arterial injury 14.06 11.65 36 1384736 700 78358916
Pericardial rub 14.05 11.65 7 1384765 14 78359602
Joint laxity 14.05 11.65 12 1384760 2332 78357284
Peripheral artery aneurysm 14.04 11.65 27 1384745 429 78359187
Vasoplegia syndrome 14.01 11.65 26 1384746 3604 78356012
Hyperaesthesia 13.99 11.65 140 1384632 12082 78347534
Lymphocyte percentage decreased 13.97 11.65 140 1384632 4836 78354780
Mesenteric artery thrombosis 13.96 11.65 33 1384739 609 78359007
Sinus arrhythmia 13.96 11.65 73 1384699 2037 78357579
Menstruation irregular 13.93 11.65 43 1384729 4993 78354623
Wound haematoma 13.92 11.65 16 1384756 155 78359461
Uvulitis 13.91 11.65 6 1384766 7 78359609
Coagulation factor VIII level decreased 13.89 11.65 8 1384764 24 78359592
Facial paresis 13.87 11.65 152 1384620 5374 78354242
Constipation 13.84 11.65 5288 1379484 277762 78081854
Jaundice 13.83 11.65 1091 1383681 52258 78307358
Electrocardiogram ST-T change 13.80 11.65 60 1384712 1549 78358067
Electrocardiogram P wave abnormal 13.77 11.65 24 1384748 352 78359264
Azotaemia 13.75 11.65 211 1384561 8065 78351551
Crying 13.74 11.65 300 1384472 22743 78336873
Cerebral aspergillosis 13.73 11.65 7 1384765 1789 78357827
Brain natriuretic peptide increased 13.69 11.65 224 1384548 8676 78350940
Eye excision 13.68 11.65 12 1384760 81 78359535
Mycobacterium tuberculosis complex test positive 13.67 11.65 17 1384755 2775 78356841
Polymyositis 13.66 11.65 95 1384677 2941 78356675
Capillary fragility test 13.66 11.65 8 1384764 25 78359591
Toxic skin eruption 13.65 11.65 289 1384483 22004 78337612
Thrombocytopenia 13.63 11.65 4257 1380515 261002 78098614
Steroid diabetes 13.63 11.65 25 1384747 3481 78356135
Intestinal obstruction 13.63 11.65 609 1384163 42411 78317205
Brain stem stroke 13.56 11.65 35 1384737 684 78358932
Pulmonary vascular disorder 13.56 11.65 45 1384727 1018 78358598
Staphylococcal bacteraemia 13.55 11.65 141 1384631 12077 78347539
Anal inflammation 13.53 11.65 4 1384768 1426 78358190
Persecutory delusion 13.52 11.65 42 1384730 4867 78354749
Actinic elastosis 13.51 11.65 10 1384762 51 78359565
Rhinitis perennial 13.50 11.65 23 1384749 331 78359285
Nodal arrhythmia 13.48 11.65 69 1384703 1909 78357707
Nodal rhythm 13.47 11.65 97 1384675 3038 78356578
Vascular graft thrombosis 13.47 11.65 18 1384754 206 78359410
Extrasystoles 13.44 11.65 192 1384580 7227 78352389
Forced expiratory volume decreased 13.42 11.65 80 1384692 7734 78351882
Pharyngeal oedema 13.42 11.65 374 1384398 15898 78343718
Prothrombin time abnormal 13.38 11.65 46 1384726 1060 78358556
Rectal ulcer 13.38 11.65 72 1384700 2032 78357584
Encephalopathy 13.38 11.65 998 1383774 66399 78293217
Device inappropriate shock delivery 13.36 11.65 10 1384762 52 78359564
Carotid artery dissection 13.35 11.65 23 1384749 334 78359282
Fanconi syndrome 13.35 11.65 18 1384754 2838 78356778
Patent ductus arteriosus 13.35 11.65 13 1384759 102 78359514
Hypertriglyceridaemia 13.34 11.65 149 1384623 12591 78347025
Cardiac procedure complication 13.32 11.65 24 1384748 362 78359254
Vascular access complication 13.29 11.65 11 1384761 2171 78357445
Dermatitis exfoliative 13.28 11.65 263 1384509 10566 78349050
Hand-eye coordination impaired 13.23 11.65 8 1384764 27 78359589
Cardiac perfusion defect 13.23 11.65 8 1384764 27 78359589
Rash pruritic 13.23 11.65 1067 1383705 70562 78289054
Mucosal erosion 13.20 11.65 77 1384695 2241 78357375
Laryngeal haematoma 13.18 11.65 16 1384756 165 78359451
Cardiac failure acute 13.16 11.65 426 1384346 18503 78341113
Diabetic nephropathy 13.14 11.65 92 1384680 2855 78356761
Blood bicarbonate decreased 13.13 11.65 143 1384629 5048 78354568
Neoplasm recurrence 13.12 11.65 34 1384738 4180 78355436
Subcapsular hepatic haematoma 13.08 11.65 6 1384766 9 78359607
Pregnancy with implant contraceptive 13.08 11.65 8 1384764 1848 78357768
Hepatitis C 13.07 11.65 138 1384634 11787 78347829
Gastric occult blood positive 13.06 11.65 5 1384767 3 78359613
Venous stenosis 13.04 11.65 20 1384752 262 78359354
Atypical mycobacterial infection 13.02 11.65 7 1384765 1736 78357880
Prostatic adenoma 12.98 11.65 13 1384759 106 78359510
Histoplasmosis disseminated 12.97 11.65 13 1384759 2340 78357276
Diabetic neuropathy 12.96 11.65 165 1384607 6051 78353565
Neutropenic colitis 12.93 11.65 53 1384719 5654 78353962
Giant cell arteritis 12.93 11.65 87 1384685 2664 78356952
Ear infection 12.93 11.65 478 1384294 33954 78325662
Pneumonitis 12.92 11.65 896 1383876 59964 78299652
Laryngotracheal oedema 12.92 11.65 9 1384763 41 78359575
Polyomavirus-associated nephropathy 12.91 11.65 52 1384720 5575 78354041
Femur fracture 12.90 11.65 544 1384228 38108 78321508
Puncture site haematoma 12.90 11.65 16 1384756 169 78359447
Presbyoesophagus 12.90 11.65 7 1384765 18 78359598
Vascular dementia 12.85 11.65 39 1384733 840 78358776
Akinesia 12.83 11.65 100 1384672 3212 78356404
Putamen haemorrhage 12.83 11.65 28 1384744 489 78359127
Tumour haemorrhage 12.82 11.65 119 1384653 4025 78355591
Choroiditis 12.82 11.65 4 1384768 1377 78358239
Spur cell anaemia 12.79 11.65 13 1384759 108 78359508
Cardiac perforation 12.77 11.65 15 1384757 149 78359467
Cardiac pacemaker insertion 12.77 11.65 156 1384616 5666 78353950
Lichen planopilaris 12.75 11.65 9 1384763 42 78359574
Therapeutic response increased 12.71 11.65 30 1384742 553 78359063
Hepatocellular carcinoma 12.69 11.65 98 1384674 8923 78350693
Impaired work ability 12.68 11.65 253 1384519 19428 78340188
Vessel perforation 12.64 11.65 7 1384765 19 78359597
Aorta hypoplasia 12.62 11.65 8 1384764 30 78359586
Cardiac function test abnormal 12.62 11.65 14 1384758 130 78359486
Acute generalised exanthematous pustulosis 12.61 11.65 217 1384555 17037 78342579
Finger deformity 12.59 11.65 77 1384695 7397 78352219
Agonal rhythm 12.57 11.65 11 1384761 74 78359542
Device use issue 12.56 11.65 18 1384754 2766 78356850
Endoscopy upper gastrointestinal tract 12.54 11.65 14 1384758 131 78359485
Nodular regenerative hyperplasia 12.53 11.65 4 1384768 1357 78358259
Osteomalacia 12.52 11.65 5 1384767 1475 78358141
Hyperthermia 12.50 11.65 229 1384543 17808 78341808
Blood phosphorus increased 12.49 11.65 117 1384655 10230 78349386
Scedosporium infection 12.49 11.65 5 1384767 1473 78358143
Sensitivity to weather change 12.48 11.65 85 1384687 7962 78351654
Body height decreased 12.48 11.65 214 1384558 8366 78351250
Jaundice hepatocellular 12.46 11.65 14 1384758 132 78359484
Blood HIV RNA increased 12.46 11.65 8 1384764 1800 78357816
Dieulafoy's vascular malformation 12.43 11.65 8 1384764 31 78359585
Genital haemorrhage 12.42 11.65 61 1384711 6194 78353422
Amputation 12.42 11.65 36 1384736 755 78358861
Hypersensitivity myocarditis 12.38 11.65 19 1384753 249 78359367
Coronary artery embolism 12.38 11.65 21 1384751 301 78359315
Blood creatinine abnormal 12.33 11.65 133 1384639 4684 78354932
Urine analysis abnormal 12.32 11.65 170 1384602 6350 78353266
Ruptured cerebral aneurysm 12.31 11.65 29 1384743 534 78359082
Procedural complication 12.30 11.65 201 1384571 7782 78351834
Malignant transformation 12.29 11.65 3 1384769 1215 78358401
Lateral medullary syndrome 12.29 11.65 10 1384762 60 78359556
SARS-CoV-2 test false negative 12.28 11.65 4 1384768 0 78359616
Capillary fragility increased 12.28 11.65 4 1384768 0 78359616
Anginal equivalent 12.28 11.65 4 1384768 0 78359616
Hemianopia homonymous 12.27 11.65 51 1384721 1290 78358326
Cytomegalovirus colitis 12.26 11.65 41 1384731 4644 78354972
Tongue haemorrhage 12.24 11.65 42 1384730 967 78358649
Organising pneumonia 12.23 11.65 126 1384646 10813 78348803
Stem cell transplant 12.22 11.65 29 1384743 3675 78355941
Transient global amnesia 12.19 11.65 41 1384731 934 78358682
Aortic occlusion 12.17 11.65 16 1384756 180 78359436
Haemorrhagic disorder 12.15 11.65 57 1384715 1521 78358095
Embolic cerebral infarction 12.15 11.65 49 1384723 1222 78358394
Tooth socket haemorrhage 12.15 11.65 12 1384760 96 78359520
Polycystic ovaries 12.14 11.65 30 1384742 3749 78355867
Fungaemia 12.14 11.65 40 1384732 4551 78355065
Base excess 12.13 11.65 11 1384761 78 78359538
White blood cell count decreased 12.08 11.65 2993 1381779 185295 78174321
Dressler's syndrome 12.07 11.65 8 1384764 33 78359583
Acute chest syndrome 12.06 11.65 6 1384766 1555 78358061
Hyperkinesia 12.05 11.65 85 1384687 2644 78356972
Malignant atrophic papulosis 12.04 11.65 6 1384766 12 78359604
Panic attack 12.04 11.65 324 1384448 23892 78335724
Arteriovenous fistula 12.00 11.65 51 1384721 1303 78358313
Anal fistula 11.98 11.65 71 1384701 6873 78352743
Flap necrosis 11.97 11.65 5 1384767 5 78359611
Eating disorder 11.96 11.65 456 1384316 20241 78339375
Influenza 11.94 11.65 2023 1382749 127583 78232033
Splenic haemorrhage 11.94 11.65 33 1384739 673 78358943
Platelet count normal 11.93 11.65 7 1384765 22 78359594
Chest wall haematoma 11.93 11.65 25 1384747 424 78359192
Catheterisation cardiac 11.92 11.65 152 1384620 5576 78354040
Pruritus genital 11.92 11.65 39 1384733 4447 78355169
Sinonasal obstruction 11.91 11.65 21 1384751 311 78359305
Angiogram abnormal 11.89 11.65 8 1384764 34 78359582
Lung transplant 11.88 11.65 40 1384732 4521 78355095
Device physical property issue 11.87 11.65 17 1384755 2613 78357003
Dry gangrene 11.85 11.65 41 1384731 948 78358668
Thoracic haemorrhage 11.85 11.65 17 1384755 209 78359407
Hyperhidrosis 11.85 11.65 2884 1381888 148608 78211008
Glomerular filtration rate increased 11.83 11.65 47 1384725 1164 78358452
Myoglobinuria 11.82 11.65 44 1384728 1056 78358560
Mesenteric arterial occlusion 11.78 11.65 18 1384754 235 78359381
Bladder sphincter atony 11.77 11.65 13 1384759 120 78359496
Corneal oedema 11.76 11.65 17 1384755 2603 78357013
Lymphangiosis carcinomatosa 11.76 11.65 12 1384760 2142 78357474
Arterial rupture 11.74 11.65 36 1384736 780 78358836
Haematocoele 11.73 11.65 6 1384766 13 78359603
Anastomotic ulcer haemorrhage 11.69 11.65 12 1384760 101 78359515
Chronic gastritis 11.68 11.65 115 1384657 3953 78355663
Onychomadesis 11.68 11.65 49 1384723 5193 78354423
Physical examination abnormal 11.68 11.65 20 1384752 289 78359327
Vessel puncture site haemorrhage 11.67 11.65 16 1384756 188 78359428
Bipolar disorder 11.66 11.65 82 1384690 7625 78351991
Upper respiratory tract infection 11.66 11.65 1395 1383377 89773 78269843
Abnormal behaviour 11.66 11.65 515 1384257 35906 78323710
Attention deficit hyperactivity disorder 11.66 11.65 25 1384747 3284 78356332

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cyst 21.21 17.52 9 1077 18 88688
Urinary tract disorder 20.30 17.52 9 1077 21 88685
Congenital acrochordon 17.62 17.52 9 1077 32 88674

Pharmacologic Action:

SourceCodeDescription
ATC A01AD05 ALIMENTARY TRACT AND METABOLISM
STOMATOLOGICAL PREPARATIONS
STOMATOLOGICAL PREPARATIONS
Other agents for local oral treatment
ATC B01AC06 BLOOD AND BLOOD FORMING ORGANS
ANTITHROMBOTIC AGENTS
ANTITHROMBOTIC AGENTS
Platelet aggregation inhibitors excl. heparin
ATC B01AC56 BLOOD AND BLOOD FORMING ORGANS
ANTITHROMBOTIC AGENTS
ANTITHROMBOTIC AGENTS
Platelet aggregation inhibitors excl. heparin
ATC C07FX02 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS, OTHER COMBINATIONS
Beta blocking agents, other combinations
ATC C07FX03 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS, OTHER COMBINATIONS
Beta blocking agents, other combinations
ATC C07FX04 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS, OTHER COMBINATIONS
Beta blocking agents, other combinations
ATC C10BX01 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX02 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX04 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX05 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX06 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX08 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX12 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC M01BA03 MUSCULO-SKELETAL SYSTEM
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
ANTIINFLAMMATORY/ANTIRHEUMATIC AGENTS IN COMBINATION
Antiinflammatory/antirheumatic agents in combination with corticosteroids
ATC N02AJ02 NERVOUS SYSTEM
ANALGESICS
OPIOIDS
Opioids in combination with non-opioid analgesics
ATC N02AJ07 NERVOUS SYSTEM
ANALGESICS
OPIOIDS
Opioids in combination with non-opioid analgesics
ATC N02AJ18 NERVOUS SYSTEM
ANALGESICS
OPIOIDS
Opioids in combination with non-opioid analgesics
ATC N02BA01 NERVOUS SYSTEM
ANALGESICS
OTHER ANALGESICS AND ANTIPYRETICS
Salicylic acid and derivatives
ATC N02BA51 NERVOUS SYSTEM
ANALGESICS
OTHER ANALGESICS AND ANTIPYRETICS
Salicylic acid and derivatives
ATC N02BA71 NERVOUS SYSTEM
ANALGESICS
OTHER ANALGESICS AND ANTIPYRETICS
Salicylic acid and derivatives
FDA CS M0001335 Anti-Inflammatory Agents, Non-Steroidal
FDA MoA N0000000160 Cyclooxygenase Inhibitors
FDA PE N0000008832 Decreased Platelet Aggregation
FDA PE N0000008836 Decreased Prostaglandin Production
FDA EPC N0000175578 Platelet Aggregation Inhibitor
MeSH PA D000700 Analgesics
MeSH PA D018712 Analgesics, Non-Narcotic
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000894 Anti-Inflammatory Agents, Non-Steroidal
MeSH PA D058633 Antipyretics
MeSH PA D018501 Antirheumatic Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D016861 Cyclooxygenase Inhibitors
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D005343 Fibrinolytic Agents
MeSH PA D006401 Hematologic Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D010975 Platelet Aggregation Inhibitors
MeSH PA D018689 Sensory System Agents
CHEBI has role CHEBI:35475 non-steroidal anti-inflammatory agent
CHEBI has role CHEBI:35493 anti-pyretic
CHEBI has role CHEBI:49023 prostaglandin inhibitor
CHEBI has role CHEBI:50249 anticoagulants
CHEBI has role CHEBI:50427 platelet aggregation inhibitors
CHEBI has role CHEBI:50629 COX-2 inhibitor
CHEBI has role CHEBI:50630 COX-1 inhibitor
CHEBI has role CHEBI:50905 teratogeno
CHEBI has role CHEBI:73182 plant activators
CHEBI has role CHEBI:77425 EC 1.1.1.188 (prostaglandin-F synthase) inhibitors
CHEBI has role CHEBI:88188 allergenic drug
CHEBI has role CHEBI:176497 geroprotectors
FDA EPC N0000175722 Nonsteroidal Anti-inflammatory Drug

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Sinus headache indication 4969004
Pain indication 22253000
Myocardial infarction indication 22298006 DOID:5844
Toothache indication 27355003
Migraine indication 37796009 DOID:6364
Joint pain indication 57676002
Rheumatoid arthritis indication 69896004 DOID:7148
Common cold indication 82272006 DOID:10459
Backache indication 161891005
Headache disorder indication 230461009
Influenza-like symptoms indication 315642008
Osteoarthritis indication 396275006
Arthritic Pain indication




🐶 Veterinary Drug Use

SpeciesUseRelation
Dogs Pain Indication
Dogs Inflammation Indication

🐶 Veterinary products

ProductApplicantIngredients
Cortaba Tablets Zoetis Inc. 2

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.57 acidic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
325MG;40MG YOSPRALA GENUS LIFESCIENCES N205103 Sept. 14, 2016 DISCN TABLET, DELAYED RELEASE ORAL 6926907 Feb. 28, 2023 TREATMENT OR SECONDARY PREVENTION OF CARDIOVASCULAR DISEASE, CARDIOVASCULAR EVENTS, OR CEREBROVASCULAR EVENTS AND RISK-REDUCTION OF ASPIRIN-ASSOCIATED GASTRIC ULCERS
325MG;40MG YOSPRALA GENUS LIFESCIENCES N205103 Sept. 14, 2016 DISCN TABLET, DELAYED RELEASE ORAL 8206741 Feb. 28, 2023 TREATMENT OR SECONDARY PREVENTION OF CARDIOVASCULAR DISEASE, CARDIOVASCULAR EVENTS, OR CEREBROVASCULAR EVENTS AND RISK-REDUCTION OF ASPIRIN-ASSOCIATED GASTRIC ULCERS
81MG;40MG YOSPRALA GENUS LIFESCIENCES N205103 Sept. 14, 2016 DISCN TABLET, DELAYED RELEASE ORAL 6926907 Feb. 28, 2023 TREATMENT OR SECONDARY PREVENTION OF CARDIOVASCULAR DISEASE, CARDIOVASCULAR EVENTS, OR CEREBROVASCULAR EVENTS AND RISK-REDUCTION OF ASPIRIN-ASSOCIATED GASTRIC ULCERS
81MG;40MG YOSPRALA GENUS LIFESCIENCES N205103 Sept. 14, 2016 DISCN TABLET, DELAYED RELEASE ORAL 8206741 Feb. 28, 2023 TREATMENT OR SECONDARY PREVENTION OF CARDIOVASCULAR DISEASE, CARDIOVASCULAR EVENTS, OR CEREBROVASCULAR EVENTS AND RISK-REDUCTION OF ASPIRIN-ASSOCIATED GASTRIC ULCERS
325MG VAZALORE PLX PHARMA N203697 Jan. 14, 2013 OTC CAPSULE ORAL 10786444 Sept. 29, 2032 A METHOD OF TARGETING RELEASE OF A NON-STEROIDAL ANTI-INFLAMMATORY DRUG (NSAID) TO THE SMALL INTESTINE OF THE SUBJECT WHEN ADMINISTERED ORALLY
325MG VAZALORE PLX PHARMA N203697 Jan. 14, 2013 OTC CAPSULE ORAL 9226892 Sept. 29, 2032 TEMPORARY REDUCTION OF FEVER
325MG VAZALORE PLX PHARMA N203697 Jan. 14, 2013 OTC CAPSULE ORAL 9226892 Sept. 29, 2032 TEMPORARY RELIEF OF MINOR ACHES AND PAINS
325MG VAZALORE PLX PHARMA N203697 Jan. 14, 2013 OTC CAPSULE ORAL 9226892 Sept. 29, 2032 TREATMENT/PREVENTION OF CARDIOVASCULAR DISEASE
81MG VAZALORE PLX PHARMA N203697 Feb. 26, 2021 OTC CAPSULE ORAL 10786444 Sept. 29, 2032 A METHOD OF TARGETING RELEASE OF A NON-STEROIDAL ANTI-INFLAMMATORY DRUG (NSAID) TO THE SMALL INTESTINE OF THE SUBJECT WHEN ADMINISTERED ORALLY
325MG;40MG YOSPRALA GENUS LIFESCIENCES N205103 Sept. 14, 2016 DISCN TABLET, DELAYED RELEASE ORAL 9987231 Jan. 2, 2033 FOR SECONDARY PREVENTION OF CARDIOVASCULAR AND CEREBROVASCULAR EVENTS IN PATIENTS AT RISK OF DEVELOPING ASPIRIN-ASSOCIATED GASTRIC ULCERS
81MG;40MG YOSPRALA GENUS LIFESCIENCES N205103 Sept. 14, 2016 DISCN TABLET, DELAYED RELEASE ORAL 9987231 Jan. 2, 2033 FOR SECONDARY PREVENTION OF CARDIOVASCULAR AND CEREBROVASCULAR EVENTS IN PATIENTS AT RISK OF DEVELOPING ASPIRIN-ASSOCIATED GASTRIC ULCERS
325MG;40MG YOSPRALA GENUS LIFESCIENCES N205103 Sept. 14, 2016 DISCN TABLET, DELAYED RELEASE ORAL 9539214 March 13, 2033 TREATMENT OR SECONDARY PREVENTION OF CARDIOVASCULAR DISEASE, CARDIOVASCULAR EVENTS, OR CEREBROVASCULAR EVENTS AND RISK-REDUCTION OF ASPIRIN-ASSOCIATED GASTRIC ULCERS
81MG;40MG YOSPRALA GENUS LIFESCIENCES N205103 Sept. 14, 2016 DISCN TABLET, DELAYED RELEASE ORAL 9539214 March 13, 2033 TREATMENT OR SECONDARY PREVENTION OF CARDIOVASCULAR DISEASE, CARDIOVASCULAR EVENTS, OR CEREBROVASCULAR EVENTS AND RISK-REDUCTION OF ASPIRIN-ASSOCIATED GASTRIC ULCERS

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Prostaglandin G/H synthase 2 Enzyme INHIBITOR IC50 5.12 WOMBAT-PK CHEMBL
Prostaglandin G/H synthase 1 Enzyme INHIBITOR IC50 5.77 WOMBAT-PK CHEMBL
Gamma-glutamyltranspeptidase 1 Enzyme IC50 4.44 CHEMBL
Acid-sensing ion channel 3 Ion channel BLOCKER IC50 4 IUPHAR
Nicotinate phosphoribosyltransferase Enzyme Ki 9.30 CHEMBL
Acidic phospholipase A2 3 Enzyme Kd 5.20 WOMBAT-PK
Prostaglandin G/H synthase 1 Enzyme IC50 6.52 CHEMBL
Prostaglandin G/H synthase 2 Enzyme IC50 5.62 CHEMBL
Prostaglandin G/H synthase 1 Enzyme IC50 6.46 CHEMBL

External reference:

IDSource
4017536 VUID
N0000145918 NUI
D00109 KEGG_DRUG
1191 RXNORM
C0004057 UMLSCUI
CHEBI:15365 CHEBI
AIN PDB_CHEM_ID
CHEMBL25 ChEMBL_ID
DB00945 DRUGBANK_ID
2244 PUBCHEM_CID
4139 IUPHAR_LIGAND_ID
493-53-8 SECONDARY_CAS_RN
132-49-0 SECONDARY_CAS_RN
25817-25-8 SECONDARY_CAS_RN
69-46-5 SECONDARY_CAS_RN
1466-82-6 SECONDARY_CAS_RN
37933-78-1 SECONDARY_CAS_RN
387458008 SNOMEDCT_US
7947003 SNOMEDCT_US
D001241 MESH_DESCRIPTOR_UI
CHEMBL1697753 ChEMBL_ID
4017536 VANDF
244 MMSL
34512 MMSL
4223 MMSL
d00170 MMSL
R16CO5Y76E UNII
001587 NDDF

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Fiorinal with Codeine HUMAN PRESCRIPTION DRUG LABEL 4 0023-6010 CAPSULE 325 mg ORAL NDA 36 sections
Fiorinal HUMAN PRESCRIPTION DRUG LABEL 3 0023-6146 CAPSULE 325 mg ORAL NDA 23 sections
ExcedrinExtra Strength Pain Reliever HUMAN OTC DRUG LABEL 3 0067-2000 TABLET, FILM COATED 250 mg ORAL OTC monograph not final 13 sections
ExcedrinExtra Strength Pain Reliever HUMAN OTC DRUG LABEL 3 0067-2000 TABLET, FILM COATED 250 mg ORAL OTC monograph not final 13 sections
ExcedrinExtra Strength Pain Reliever HUMAN OTC DRUG LABEL 3 0067-2001 TABLET, FILM COATED 250 mg ORAL OTC monograph not final 15 sections
ExcedrinExtra Strength Pain Reliever HUMAN OTC DRUG LABEL 3 0067-2001 TABLET, FILM COATED 250 mg ORAL OTC monograph not final 15 sections
ExcedrinExtra Strength Geltabs HUMAN OTC DRUG LABEL 3 0067-2021 TABLET, COATED 250 mg ORAL OTC monograph not final 14 sections
ExcedrinMigraine Geltabs HUMAN OTC DRUG LABEL 3 0067-2035 TABLET, COATED 250 mg ORAL NDA 14 sections
EXCEDRINMIGRAINE HUMAN OTC DRUG LABEL 3 0067-2039 TABLET, FILM COATED 250 mg ORAL NDA 15 sections
EXCEDRINMIGRAINE HUMAN OTC DRUG LABEL 3 0067-2039 TABLET, FILM COATED 250 mg ORAL NDA 15 sections
ExcedrinMigraine HUMAN OTC DRUG LABEL 3 0067-2040 TABLET, FILM COATED 250 mg ORAL NDA 16 sections
ExcedrinMigraine HUMAN OTC DRUG LABEL 3 0067-2040 TABLET, FILM COATED 250 mg ORAL NDA 16 sections
Excedrin PM Triple Action Caplets HUMAN OTC DRUG LABEL 3 0067-2056 TABLET, COATED 250 mg ORAL OTC monograph not final 16 sections
Excedrin PM Triple Action Caplets HUMAN OTC DRUG LABEL 3 0067-2056 TABLET, COATED 250 mg ORAL OTC monograph not final 16 sections
EXCEDRINMIGRAINE HUMAN OTC DRUG LABEL 3 0067-8201 TABLET, FILM COATED 250 mg ORAL NDA 15 sections
EXCEDRINMIGRAINE HUMAN OTC DRUG LABEL 3 0067-8201 TABLET, FILM COATED 250 mg ORAL NDA 15 sections
ExcedrinExtra Strength Pain Reliever HUMAN OTC DRUG LABEL 3 0067-8202 TABLET, FILM COATED 250 mg ORAL OTC monograph not final 15 sections
ExcedrinExtra Strength Pain Reliever HUMAN OTC DRUG LABEL 3 0067-8202 TABLET, FILM COATED 250 mg ORAL OTC monograph not final 15 sections
ExcedrinExtra Strength Pain Reliever HUMAN OTC DRUG LABEL 3 0067-8203 TABLET, FILM COATED 250 mg ORAL OTC monograph not final 15 sections
good sense aspirin HUMAN OTC DRUG LABEL 1 0113-0259 TABLET, CHEWABLE 81 mg ORAL OTC monograph not final 15 sections
Good Sense aspirin HUMAN OTC DRUG LABEL 1 0113-0274 TABLET, CHEWABLE 81 mg ORAL OTC monograph not final 15 sections
Good Sense aspirin HUMAN OTC DRUG LABEL 1 0113-0274 TABLET, CHEWABLE 81 mg ORAL OTC monograph not final 15 sections
good sense migraine formula HUMAN OTC DRUG LABEL 3 0113-0374 TABLET, FILM COATED 250 mg ORAL ANDA 15 sections
good sense migraine formula HUMAN OTC DRUG LABEL 3 0113-0374 TABLET, FILM COATED 250 mg ORAL ANDA 15 sections
good sense aspirin HUMAN OTC DRUG LABEL 1 0113-0416 TABLET, FILM COATED 325 mg ORAL OTC monograph not final 15 sections
good sense aspirin HUMAN OTC DRUG LABEL 1 0113-0467 TABLET, CHEWABLE 81 mg ORAL OTC monograph not final 15 sections
good sense aspirin HUMAN OTC DRUG LABEL 1 0113-0467 TABLET, CHEWABLE 81 mg ORAL OTC monograph not final 15 sections
Basic Care Aspirin HUMAN OTC DRUG LABEL 1 0113-0773 TABLET, FILM COATED 325 mg ORAL OTC monograph not final 15 sections
good sense migraine formula HUMAN OTC DRUG LABEL 3 0113-1619 TABLET, FILM COATED 250 mg ORAL ANDA 15 sections
good sense headache relief HUMAN OTC DRUG LABEL 3 0113-1855 TABLET, FILM COATED 250 mg ORAL OTC monograph not final 15 sections