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acetoxolone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| steroids not used as glucocorticosteroids | 62 | 6277-14-1 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
|
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| azlogd74 | LogD at pH 7.4 | 3.632 | High | 0.81 | |
| caco2-efflux | Caco-2 efflux ratio (BA/AB) | 0.483 | High | 0.81 | |
| caco2-intrinsic-papp | Caco-2 intrinsic apparent permeability | 65.766 | 10^-6 cm/s | High | 0.81 |
| dh-clint | Dog hepatocyte intrinsic clearance | 17.458 | uL/min/10^6 cells | High | 0.81 |
| dppb | Dog plasma protein binding (% unbound) | 0.730 | % | High | 0.81 |
| herg | hERG pIC50 | 4.990 | pIC50 | High | 0.81 |
| fcs-ppb | Fetal calf serum protein binding (% unbound) | 1.700 | % | High | 0.81 |
| hh-clint | Human hepatocyte intrinsic clearance | 6.808 | uL/min/10^6 cells | High | 0.81 |
| hlm-clint | Human liver microsomal intrinsic clearance | 15.346 | uL/min/mg protein | High | 0.81 |
| hppb | Human plasma protein binding (% unbound) | 0.860 | % | High | 0.81 |
| kinase-safety-class | ACVR2B,AXL,CAMK2D,CDK5,CDK9,EIF2AK3,ERBB2,GRK2,ITK,MAPK7,PDK1,PDK2,PRKDC | 13 | |||
| kinase-selectivity-class | EIF2AK3,GRK2 | 2 | |||
| mdck-mdr1-efflux | MDCK-MDR1 efflux ratio | 1.138 | High | 0.81 | |
| mh-clint | Mouse hepatocyte intrinsic clearance | 18.197 | High | 0.81 | |
| mppb | Mouse plasma protein binding (% unbound) | 1.050 | High | 0.81 | |
| nih-mdck-mdr1-efflux | NIH MDCK-MDR1 efflux ratio | 5.058 | High | 0.81 | |
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 | |||
| pppb | Pig plasma protein binding (% unbound) | 0.670 | % | High | 0.81 |
| rh-clint | Rat hepatocyte intrinsic clearance | 15.812 | uL/min/10^6 cells | High | 0.81 |
| rh-fuinc | Rat hepatocyte fraction unbound in incubation | 10.090 | % | High | 0.81 |
| rppb | Rat plasma protein binding (% unbound) | 0.950 | % | High | 0.81 |
| solubility-dd | Solubility at pH 7.4 in DMSO | 101.859 | uM | High | 0.81 |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | A02BX09 | ALIMENTARY TRACT AND METABOLISM DRUGS FOR ACID RELATED DISORDERS DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD) Other drugs for peptic ulcer and gastro-oesophageal reflux disease (GORD) |
| CHEBI has role | CHEBI:49201 | anti-ulcer drug |
Related Drugs by ATC class:
A02BX Other drugs for peptic ulcer and gastro-oesophageal reflux disease (GORD) 15 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Gastritis | indication | 4556007 | DOID:4029 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 4.89 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Liver carboxylesterase 1 | Enzyme | IC50 | 4.30 | CHEMBL | |||||
| Estradiol 17-beta-dehydrogenase 1 | Enzyme | IC50 | 4.73 | CHEMBL | |||||
| Estradiol 17-beta-dehydrogenase 2 | Enzyme | IC50 | 5.42 | CHEMBL | |||||
| Corticosteroid 11-beta-dehydrogenase isozyme 2 | Enzyme | IC50 | 6.70 | CHEMBL | |||||
| Corticosteroid 11-beta-dehydrogenase isozyme 1 | Enzyme | IC50 | 6.10 | CHEMBL | |||||
| Cocaine esterase | Enzyme | IC50 | 4.39 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 16784 | RXNORM |
| C0050521 | UMLSCUI |
| CHEBI:81306 | CHEBI |
| CHEMBL207413 | ChEMBL_ID |
| DB13640 | DRUGBANK_ID |
| C013384 | MESH_SUPPLEMENTAL_RECORD_UI |
| CWW961Q19K | UNII |
| 94320 | PUBCHEM_CID |
| 004300 | NDDF |
Pharmaceutical products:
None