sucralfate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4106	54182-58-0

Description:

Molecule	Description
Synonyms: sucralfate antepsin carafate sucralfin sucrate sulcrate ulcerlmin ulcogant	A basic aluminum complex of sulfated sucrose. Molecular weight: Formula: None CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: ALOGS: ROTB: None

Molecule

Description

Synonyms:

sucralfate
antepsin
carafate
sucralfin
sucrate
sulcrate
ulcerlmin
ulcogant

A basic aluminum complex of sulfated sucrose.

Molecular weight:
Formula: None
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA:
ALOGS:
ROTB: None

Drug dosage:

Dose	Unit	Route
4	g	O

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Oct. 30, 1981	FDA	FOREST LABS INC

FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Vaginal flatulence	119.24	12.00	48	29280	3245	63456449
Proctitis	108.10	12.00	52	29276	5389	63454305
Female genital tract fistula	94.69	12.00	53	29275	7506	63452188
Radiculopathy	88.27	12.00	53	29275	8558	63451136
Vaginal discharge	80.03	12.00	51	29277	9147	63450547
Maternal exposure during pregnancy	78.83	12.00	6	29322	220056	63239638
Drug ineffective	73.18	12.00	244	29084	1044521	62415173
Contraindicated product administered	72.44	12.00	8	29320	217640	63242054
Abdominal pain	66.51	12.00	290	29038	293166	63166528
Cholecystitis chronic	65.18	12.00	47	29281	10314	63449380

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FDA Adverse Event Reporting System (Male)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Gastrointestinal haemorrhage	47.04	11.95	106	13645	88371	34854809
Blood aluminium increased	38.62	11.95	6	13745	3	34943177
Gastrooesophageal reflux disease	34.39	11.95	57	13694	37867	34905313
Oesophagitis	31.29	11.95	32	13719	13229	34929951
Asthma-chronic obstructive pulmonary disease overlap syndrome	23.38	11.95	11	13740	1276	34941904
Dysphagia	22.92	11.95	65	13686	62316	34880864
Brugada syndrome	21.49	11.95	9	13742	792	34942388
Completed suicide	21.48	11.95	6	13745	98162	34845018
Vomiting	20.61	11.95	167	13584	247454	34695726
Gastric mucosal calcinosis	20.52	11.95	3	13748	0	34943180

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FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Toxicity to various agents	61.70	11.18	52	33474	421488	79289374
Oesophagitis	58.28	11.18	61	33465	24228	79686634
Gastrointestinal haemorrhage	57.51	11.18	164	33362	147555	79563307
Cholecystitis chronic	54.67	11.18	40	33486	9866	79700996
Nausea	52.44	11.18	623	32903	956573	78754289
Gastritis	50.43	11.18	80	33446	47913	79662949
Completed suicide	48.97	11.18	21	33505	245746	79465116
Gastrooesophageal reflux disease	48.89	11.18	124	33402	104122	79606740
Abdominal pain	47.48	11.18	303	33223	389266	79321596
Vaginal flatulence	45.35	11.18	22	33504	2553	79708309

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FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

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Source	Code	Description
ATC	A02BX02	ALIMENTARY TRACT AND METABOLISM DRUGS FOR ACID RELATED DISORDERS DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD) Other drugs for peptic ulcer and gastro-oesophageal reflux disease (GORD)
FDA CS	M0015420	Organometallic Compounds
FDA EPC	N0000175801	Aluminum Complex
MeSH PA	D000897	Anti-Ulcer Agents
MeSH PA	D005765	Gastrointestinal Agents

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Drug Use | Suggest Off label Use Form| |View source of the data|

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Disease	Relation	SNOMED_ID	DOID
Duodenal ulcer disease	indication	51868009	DOID:1724
Maintenance of Healing Duodenal Ulcer	indication
Gingivostomatitis	off-label use	20607006
Peptic reflux disease	off-label use	57643001
Stomatitis	off-label use	61170000	DOID:9637
Gastroesophageal reflux disease	off-label use	235595009	DOID:8534
Gastric ulcer	off-label use	397825006	DOID:10808
NSAID-Induced Duodenal Ulcer	off-label use
Sclerotherapy Induced Esophageal Ulcer	off-label use
Stress-Related GI Mucosal Bleeding Prevention	off-label use

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🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Pepsin A-5	Enzyme	P0DJD9	PEPA5_HUMAN	INHIBITOR				CHEMBL	CHEMBL

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External reference:

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ID	Source
001132	NDDF
10156	RXNORM
121494085	PUBCHEM_CID
1948	MMSL
2723	INN_ID
387387008	SNOMEDCT_US
4018816	VUID
4018816	VANDF
476	MMSL
5518	MMSL

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Pharmaceutical products:

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Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Carafate	HUMAN PRESCRIPTION DRUG LABEL	1	17856-0170	SUSPENSION	1 g	ORAL	NDA	19 sections
Sucralfate	HUMAN PRESCRIPTION DRUG LABEL	1	0093-2210	TABLET	1 g	ORAL	ANDA	20 sections
Sucralfate	HUMAN PRESCRIPTION DRUG LABEL	1	0093-2210	TABLET	1 g	ORAL	ANDA	20 sections
Sucralfate	HUMAN PRESCRIPTION DRUG LABEL	1	0121-0747	SUSPENSION	1 g	ORAL	NDA	20 sections
Sucralfate	HUMAN PRESCRIPTION DRUG LABEL	1	0121-0974	SUSPENSION	1 g	ORAL	ANDA	17 sections
Sucralfate	HUMAN PRESCRIPTION DRUG LABEL	1	0121-0974	SUSPENSION	1 g	ORAL	ANDA	17 sections
Sucralfate	HUMAN PRESCRIPTION DRUG LABEL	1	0254-1011	SUSPENSION	1 g	ORAL	NDA authorized generic	19 sections
sucralfate	HUMAN PRESCRIPTION DRUG LABEL	1	0378-9205	SUSPENSION	1 g	ORAL	ANDA	20 sections
Sucralfate	HUMAN PRESCRIPTION DRUG LABEL	1	0615-4517	TABLET	1 g	ORAL	ANDA	20 sections
Sucralfate	HUMAN PRESCRIPTION DRUG LABEL	1	0904-7269	SUSPENSION	1 g	ORAL	ANDA	17 sections

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