rebamipide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
2360 90098-04-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • OPC-12759
  • rebamipide
  • proamipide
  • mucosta
Rebamipide is a mucosal protective agent and is postulated to increase gastric blood flow, prostaglandin biosynthesis and decrease free oxygen radicals.
  • Molecular weight: 370.79
  • Formula: C19H15ClN2O4
  • CLOGP: 1.97
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 3
  • TPSA: 95.50
  • ALOGS: -4.56
  • ROTB: 5

Drug dosage:

DoseUnitRoute
0.30 g O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 4 Hosey CM, Chan R, Benet LZ

Approvals:

DateAgencyCompanyOrphan
Sept. 26, 2011 PMDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hepatic function abnormal 244.73 17.32 120 9290 32561 50563153
Platelet count decreased 224.92 17.32 170 9240 100556 50495158
Interstitial lung disease 200.17 17.32 124 9286 53052 50542662
Drug eruption 104.09 17.32 61 9349 23545 50572169
Drug ineffective 86.77 17.32 23 9387 819310 49776404
Fatigue 78.46 17.32 18 9392 707583 49888131
Malignant neoplasm progression 76.67 17.32 78 9332 68046 50527668
White blood cell count decreased 76.34 17.32 101 9309 116621 50479093
Spinal compression fracture 72.93 17.32 39 9371 12617 50583097
Osteonecrosis of jaw 72.59 17.32 55 9355 32471 50563243
Liver disorder 72.36 17.32 58 9352 37164 50558550
Pyrexia 69.30 17.32 190 9220 380013 50215701
Cerebral infarction 60.67 17.32 42 9368 21562 50574152
Blood bilirubin increased 60.31 17.32 49 9361 31989 50563725
Neutrophil count decreased 57.87 17.32 56 9354 45970 50549744
Renal impairment 51.79 17.32 67 9343 75594 50520120
Anaemia 50.76 17.32 131 9279 252325 50343389
Altered state of consciousness 48.76 17.32 37 9373 21873 50573841
Erythema multiforme 44.17 17.32 25 9385 9025 50586689
Haemorrhage subcutaneous 43.39 17.32 17 9393 2684 50593030
Iron deficiency anaemia 43.25 17.32 31 9379 16803 50578911
Upper respiratory tract inflammation 41.80 17.32 16 9394 2373 50593341
Decreased appetite 41.11 17.32 105 9305 200818 50394896
Disseminated intravascular coagulation 40.50 17.32 30 9380 17105 50578609
Alanine aminotransferase increased 39.58 17.32 64 9346 88295 50507419
Blood pressure decreased 39.01 17.32 50 9360 55859 50539855
Aspartate aminotransferase increased 38.39 17.32 59 9351 77939 50517775
Joint swelling 34.54 17.32 3 9407 245283 50350431
Cancer pain 33.68 17.32 14 9396 2573 50593141
Cardiac failure 32.59 17.32 54 9356 75986 50519728
Pain 32.49 17.32 36 9374 578867 50016847
Gastric ulcer haemorrhage 32.12 17.32 16 9394 4468 50591246
Concomitant disease aggravated 30.70 17.32 19 9391 8072 50587642
Drug hypersensitivity 30.60 17.32 5 9405 251005 50344709
Toxicity to various agents 28.85 17.32 3 9407 212496 50383218
Drug-induced liver injury 27.69 17.32 30 9380 28065 50567649
Pancytopenia 27.43 17.32 53 9357 83977 50511737
Febrile neutropenia 26.44 17.32 57 9353 97610 50498104
Enterocolitis 26.40 17.32 16 9394 6551 50589163
Fulminant type 1 diabetes mellitus 26.16 17.32 7 9403 326 50595388
Peritonitis 25.63 17.32 22 9388 15464 50580250
Drug intolerance 25.32 17.32 5 9405 219099 50376615
Pneumonia bacterial 24.82 17.32 16 9394 7293 50588421
Cutaneous symptom 24.54 17.32 6 9404 194 50595520
Ileus 24.39 17.32 20 9390 13209 50582505
Adrenocorticotropic hormone deficiency 22.80 17.32 6 9404 262 50595452
Duodenal ulcer haemorrhage 22.53 17.32 10 9400 2156 50593558
Gastrointestinal perforation 22.15 17.32 11 9399 3050 50592664
Colony stimulating factor therapy 21.78 17.32 6 9404 312 50595402
Gamma-glutamyltransferase increased 21.45 17.32 27 9383 29596 50566118
Swelling 20.43 17.32 6 9404 200866 50394848
Enteritis infectious 20.43 17.32 9 9401 1906 50593808
Compression fracture 20.37 17.32 13 9397 5824 50589890
Infective spondylitis 20.24 17.32 5 9405 169 50595545
Colon cancer 20.05 17.32 15 9395 8676 50587038
Product dose omission issue 19.62 17.32 5 9405 183833 50411881
Pharyngitis 19.58 17.32 20 9390 17483 50578231
Haemoglobin decreased 19.57 17.32 60 9350 127156 50468558
Gastric cancer 19.37 17.32 10 9400 3008 50592706
Sputum retention 19.35 17.32 6 9404 473 50595241
Malignant pleural effusion 18.74 17.32 9 9401 2321 50593393
Pyelonephritis 18.38 17.32 18 9392 14971 50580743
Paronychia 18.04 17.32 11 9399 4553 50591161
Blood alkaline phosphatase increased 17.91 17.32 28 9382 37498 50558216
Blood lactate dehydrogenase increased 17.74 17.32 20 9390 19542 50576172
Infusion related reaction 17.36 17.32 5 9405 169552 50426162

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Interstitial lung disease 209.58 18.90 154 8181 57564 29508628
Hepatic function abnormal 170.68 18.90 117 8218 39142 29527050
Platelet count decreased 91.43 18.90 129 8206 104543 29461649
Malignant neoplasm progression 70.37 18.90 95 8240 73764 29492428
Disseminated intravascular coagulation 60.60 18.90 48 8287 19932 29546260
Upper respiratory tract inflammation 59.88 18.90 21 8314 1599 29564593
Cerebral infarction 59.70 18.90 52 8283 24623 29541569
Fatigue 55.63 18.90 11 8324 316810 29249382
Neutrophil count decreased 52.46 18.90 63 8272 43504 29522688
Drug eruption 48.16 18.90 39 8296 16702 29549490
Renal impairment 45.65 18.90 82 8253 81251 29484941
White blood cell count decreased 41.71 18.90 80 8255 83282 29482910
Pyrexia 37.44 18.90 170 8165 287452 29278740
Stomatitis 37.22 18.90 49 8286 37064 29529128
Drug ineffective 37.11 18.90 29 8306 363141 29203051
Decreased appetite 35.05 18.90 105 8230 145237 29420955
Drug-induced liver injury 30.55 18.90 34 8301 21621 29544571
Eosinophil count increased 29.69 18.90 21 8314 7348 29558844
Gastric ulcer haemorrhage 29.57 18.90 18 8317 4896 29561296
C-reactive protein increased 29.23 18.90 48 8287 44215 29521977
Hyperuricaemia 28.61 18.90 20 8315 6869 29559323
Liver disorder 28.38 18.90 37 8298 27712 29538480
Spinal compression fracture 26.03 18.90 18 8317 6076 29560116
Pneumonia bacterial 25.26 18.90 21 8314 9322 29556870
Gastric ulcer 25.04 18.90 25 8310 14036 29552156
Aspartate aminotransferase increased 24.70 18.90 53 8282 59672 29506520
Pneumonia aspiration 24.47 18.90 40 8295 36697 29529495
Altered state of consciousness 24.30 18.90 29 8306 19860 29546332
Cancer pain 23.45 18.90 12 8323 2335 29563857
Osteonecrosis of jaw 23.42 18.90 26 8309 16484 29549708
Gastric cancer 22.47 18.90 15 8320 4779 29561413
Prescribed underdose 22.09 18.90 18 8317 7768 29558424
Blood lactate dehydrogenase increased 21.83 18.90 27 8308 19182 29547010
Confusional state 21.22 18.90 5 8330 127872 29438320
Lymphangiosis carcinomatosa 20.67 18.90 8 8327 804 29565388
Death 20.54 18.90 41 8294 342043 29224149
Cholangitis 20.50 18.90 17 8318 7520 29558672
Erythema multiforme 20.14 18.90 17 8318 7700 29558492
Anaemia 19.83 18.90 110 8225 200841 29365351
Asthenia 19.71 18.90 19 8316 215231 29350961
Shunt stenosis 19.36 18.90 7 8328 582 29565610
Gamma-glutamyltransferase increased 19.01 18.90 30 8305 26707 29539485

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Interstitial lung disease 386.80 15.23 276 18086 97456 64382914
Hepatic function abnormal 374.14 15.23 231 18131 64082 64416288
Platelet count decreased 291.65 15.23 295 18067 167416 64312954
Malignant neoplasm progression 150.91 15.23 173 18189 112698 64367672
Drug eruption 133.39 15.23 98 18264 36038 64444332
Fatigue 127.24 15.23 29 18333 748701 63731669
White blood cell count decreased 115.23 15.23 180 18182 157657 64322713
Cerebral infarction 111.78 15.23 93 18269 40951 64439419
Drug ineffective 110.36 15.23 51 18311 840196 63640174
Neutrophil count decreased 100.87 15.23 117 18245 77079 64403291
Disseminated intravascular coagulation 97.99 15.23 78 18284 32270 64448100
Upper respiratory tract inflammation 94.98 15.23 37 18325 3745 64476625
Liver disorder 92.70 15.23 94 18268 53257 64427113
Spinal compression fracture 88.10 15.23 54 18308 14721 64465649
Renal impairment 86.26 15.23 145 18217 134872 64345498
Pyrexia 85.32 15.23 349 18013 558295 63922075
Osteonecrosis of jaw 83.89 15.23 78 18284 39747 64440623
Toxicity to various agents 83.60 15.23 5 18357 363508 64116862
Decreased appetite 73.97 15.23 211 18151 281078 64199292
Blood bilirubin increased 61.77 15.23 79 18283 57474 64422896
Altered state of consciousness 60.80 15.23 64 18298 37838 64442532
Cancer pain 58.03 15.23 27 18335 4230 64476140
Gastric ulcer haemorrhage 56.98 15.23 33 18329 8110 64472260
Anaemia 56.38 15.23 235 18127 378445 64101925
Erythema multiforme 54.37 15.23 41 18321 15660 64464710
Confusional state 53.37 15.23 6 18356 261138 64219232
Aspartate aminotransferase increased 51.91 15.23 109 18253 119679 64360691
Pain 51.66 15.23 49 18313 553462 63926908
Drug-induced liver injury 47.38 15.23 63 18299 47580 64432790
Drug hypersensitivity 47.27 15.23 6 18356 237809 64242561
Pneumonia bacterial 47.12 15.23 37 18325 14998 64465372
Joint swelling 46.49 15.23 4 18358 215378 64264992
Haemorrhage subcutaneous 45.40 15.23 23 18339 4338 64476032
Cardiac failure 44.59 15.23 109 18253 132264 64348106
Alanine aminotransferase increased 44.22 15.23 112 18250 138919 64341451
Completed suicide 43.79 15.23 6 18356 224408 64255962
Stomatitis 43.21 15.23 96 18266 109509 64370861
Hyperuricaemia 40.68 15.23 29 18333 10162 64470208
Blood pressure decreased 40.35 15.23 81 18281 86118 64394252
Gastric cancer 39.39 15.23 24 18338 6469 64473901
Hypotension 38.80 15.23 31 18331 380943 64099427
Blood lactate dehydrogenase increased 38.02 15.23 47 18315 33031 64447339
Gamma-glutamyltransferase increased 37.67 15.23 57 18305 48453 64431917
Fulminant type 1 diabetes mellitus 35.99 15.23 13 18349 1067 64479303
Enteritis infectious 34.56 15.23 17 18345 3011 64477359
Drug intolerance 34.45 15.23 6 18356 187986 64292384
Anxiety 33.95 15.23 8 18354 202641 64277729
Iron deficiency anaemia 33.40 15.23 36 18326 21853 64458517
Gastric ulcer 33.21 15.23 42 18320 30192 64450178
C-reactive protein increased 32.85 15.23 79 18283 94830 64385540
Enterocolitis 32.21 15.23 27 18335 11991 64468379
Peripheral swelling 31.77 15.23 10 18352 209143 64271227
Peritonitis 31.11 15.23 37 18325 24986 64455384
Pneumonia aspiration 30.53 15.23 58 18304 59213 64421157
Eosinophil count increased 30.40 15.23 28 18334 14084 64466286
Product dose omission issue 30.14 15.23 9 18353 194738 64285632
Dyspnoea 28.50 15.23 107 18255 718567 63761803
Gastrointestinal perforation 27.76 15.23 18 18344 5406 64474964
Asthenia 27.46 15.23 50 18312 427994 64052376
Death 27.04 15.23 61 18301 482644 63997726
Colon cancer 26.90 15.23 25 18337 12714 64467656
Pneumonia 26.46 15.23 259 18103 559317 63921053
Haemoglobin decreased 25.83 15.23 117 18245 194946 64285424
Infective spondylitis 25.75 15.23 8 18354 412 64479958
Small intestine ulcer 25.65 15.23 9 18353 679 64479691
Swelling 25.53 15.23 7 18355 160211 64320159
Blood alkaline phosphatase increased 25.28 15.23 52 18310 56227 64424143
Shunt stenosis 25.25 15.23 10 18352 1057 64479313
Hypoalbuminaemia 25.11 15.23 28 18334 17646 64462724
Pharyngitis 25.07 15.23 29 18333 19010 64461360
Concomitant disease aggravated 25.05 15.23 23 18339 11519 64468851
Constipation 24.94 15.23 130 18232 229207 64251163
Radiation pneumonitis 24.66 15.23 14 18348 3314 64477056
Shock haemorrhagic 24.54 15.23 27 18335 16764 64463606
Compression fracture 24.42 15.23 17 18345 5735 64474635
Infusion related reaction 23.02 15.23 9 18353 164458 64315912
Prescribed underdose 22.99 15.23 27 18335 17988 64462382
Sputum retention 22.94 15.23 9 18353 928 64479442
Weight decreased 22.51 15.23 29 18333 285710 64194660
Cholangitis 22.43 15.23 21 18341 10781 64469589
Chronic gastritis 22.32 15.23 13 18349 3227 64477143
Herpes zoster 22.31 15.23 61 18301 79126 64401244
Febrile neutropenia 22.24 15.23 109 18253 187548 64292822
Hypopituitarism 21.86 15.23 12 18350 2661 64477709
Cutaneous symptom 21.29 15.23 7 18355 433 64479937
Hepatitis fulminant 20.87 15.23 16 18346 6258 64474112
Duodenal ulcer haemorrhage 20.76 15.23 16 18346 6309 64474061
Post herpetic neuralgia 20.67 15.23 11 18351 2294 64478076
Hypocalcaemia 20.45 15.23 40 18322 41713 64438657
Idiopathic pulmonary fibrosis 20.41 15.23 13 18349 3787 64476583
Cerebral haemorrhage 20.40 15.23 45 18317 51045 64429325
Paronychia 20.39 15.23 16 18346 6476 64473894
Adrenocorticotropic hormone deficiency 20.14 15.23 8 18354 852 64479518
Lymphangiosis carcinomatosa 20.12 15.23 10 18352 1811 64478559
Pleural effusion 19.90 15.23 80 18282 126479 64353891
Cytomegalovirus enterocolitis 19.74 15.23 9 18353 1346 64479024
Cerebellar haemorrhage 19.28 15.23 11 18351 2626 64477744
Ileus 19.28 15.23 28 18334 22938 64457432
Pyelonephritis acute 19.10 15.23 14 18348 5120 64475250
Pancytopenia 18.99 15.23 86 18276 143223 64337147
Hypersensitivity 18.73 15.23 17 18345 196435 64283935
Pneumothorax 18.08 15.23 28 18334 24270 64456100
Cholecystitis 18.05 15.23 25 18337 19611 64460759
Cholecystitis acute 17.88 15.23 19 18343 11341 64469029
Rash 17.76 15.23 204 18158 458345 64022025
Blood urea increased 17.75 15.23 39 18323 44114 64436256
White blood cell count increased 17.75 15.23 50 18312 65964 64414406
Weight increased 17.48 15.23 21 18341 213327 64267043
Pyelonephritis 17.42 15.23 23 18339 17243 64463127
Shunt occlusion 17.40 15.23 8 18354 1219 64479151
Syncope 17.08 15.23 12 18350 157623 64322747
Metastases to liver 17.00 15.23 27 18335 23914 64456456
Periodontitis 16.98 15.23 12 18350 4147 64476223
Atypical mycobacterial infection 16.91 15.23 8 18354 1300 64479070
Ocular dysmetria 16.90 15.23 4 18358 72 64480298
Pneumocystis jirovecii pneumonia 16.71 15.23 29 18333 27605 64452765
Enterocolitis bacterial 16.66 15.23 6 18356 488 64479882
Pulmonary alveolar haemorrhage 16.61 15.23 17 18345 9721 64470649
Diabetes mellitus 16.57 15.23 49 18313 66425 64413945
Aortic dissection 16.55 15.23 11 18351 3441 64476929
Eczema 16.45 15.23 30 18332 29690 64450680
Colony stimulating factor therapy 16.42 15.23 6 18356 509 64479861
Subdural haematoma 16.40 15.23 29 18333 28025 64452345
Cellulitis 16.18 15.23 61 18301 93596 64386774
Dyslalia 15.80 15.23 7 18355 978 64479392
Ileal ulcer 15.65 15.23 7 18355 1001 64479369
Brain stem haemorrhage 15.62 15.23 8 18354 1543 64478827
Malignant pleural effusion 15.56 15.23 10 18352 2957 64477413
Insomnia 15.56 15.23 103 18259 197733 64282637
Rhinitis allergic 15.43 15.23 15 18347 8063 64472307
Eosinophilic pustular folliculitis 15.36 15.23 4 18358 108 64480262
Cardiac failure acute 15.31 15.23 21 18341 16323 64464047
Thalamus haemorrhage 15.29 15.23 8 18354 1611 64478759

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A02BX14 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR ACID RELATED DISORDERS
DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
Other drugs for peptic ulcer and gastro-oesophageal reflux disease (GORD)
MeSH PA D000897 Anti-Ulcer Agents
MeSH PA D000975 Antioxidants
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D005765 Gastrointestinal Agents
MeSH PA D020011 Protective Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Gastritis indication 4556007 DOID:4029
Peptic ulcer indication 13200003 DOID:750




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.32 acidic
pKa2 12.06 acidic
pKa3 13.42 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Cholecystokinin receptor type A GPCR AGONIST IC50 4.40 IUPHAR

External reference:

IDSource
D01121 KEGG_DRUG
C0069562 UMLSCUI
CHEBI:32090 CHEBI
CHEMBL1697771 ChEMBL_ID
DB11656 DRUGBANK_ID
C052785 MESH_SUPPLEMENTAL_RECORD_UI
5042 PUBCHEM_CID
871 IUPHAR_LIGAND_ID
6454 INN_ID
LR583V32ZR UNII
1172393005 SNOMEDCT_US
1172878003 SNOMEDCT_US

Pharmaceutical products:

None