rebamipide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
2360 90098-04-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • OPC-12759
  • rebamipide
  • proamipide
  • mucosta
Rebamipide is a mucosal protective agent and is postulated to increase gastric blood flow, prostaglandin biosynthesis and decrease free oxygen radicals.
  • Molecular weight: 370.79
  • Formula: C19H15ClN2O4
  • CLOGP: 1.97
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 3
  • TPSA: 95.50
  • ALOGS: -4.56
  • ROTB: 5

Drug dosage:

DoseUnitRoute
0.30 g O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 4 Hosey CM, Chan R, Benet LZ
S (Water solubility) 0.03 mg/mL Bocci G, Oprea TI, Benet LZ
BA (Bioavailability) 8 %

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,ERBB2,FLT3,GRK2,GRK3,ITK,JAK2,MAP3K21,MAP3K7,MAPK7,MAPK9,MAPKAPK2,NTRK2,PDK1,PDK2,PDK4,PIK3CB,PIK3CD,PIM2,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TTK 38
kinase-selectivity-class ACVR2B,AXL,BRAF,CDK9,DYRK1B,EIF2AK3,GRK2,GRK3,MAPK7,MAPK8,STK33,TEK 12
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
Sept. 26, 2011 PMDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hepatic function abnormal 325.62 18.92 149 12522 46139 90569637
Platelet count decreased 292.02 18.92 201 12470 136768 90479008
Interstitial lung disease 284.62 18.92 160 12511 76245 90539531
Drug eruption 142.23 18.92 78 12593 35329 90580447
White blood cell count decreased 108.41 18.92 125 12546 166984 90448792
Anaemia 108.28 18.92 184 12487 352618 90263158
Drug ineffective 104.99 18.92 32 12639 1384266 89231510
Cerebral infarction 102.43 18.92 57 12614 26539 90589237
Spinal compression fracture 100.80 18.92 47 12624 15131 90600645
Renal impairment 95.15 18.92 94 12577 105327 90510449
Neutrophil count decreased 92.40 18.92 78 12593 71454 90544322
Pyrexia 91.31 18.92 249 12422 660236 89955540
Malignant neoplasm progression 90.40 18.92 92 12579 106778 90508998
Osteonecrosis of jaw 89.32 18.92 60 12611 39043 90576733
Fatigue 88.62 18.92 26 12645 1153997 89461779
Altered state of consciousness 83.30 18.92 53 12618 31479 90584297
Milk-alkali syndrome 79.38 18.92 21 12650 1252 90614524
Erythema multiforme 75.41 18.92 36 12635 12210 90603566
Blood bilirubin increased 67.95 18.92 53 12618 43417 90572359
Gastric ulcer haemorrhage 67.22 18.92 26 12645 5285 90610491
Disseminated intravascular coagulation 63.95 18.92 39 12632 21499 90594277
Blood pressure decreased 62.44 18.92 64 12607 74831 90540945
Aspartate aminotransferase increased 60.07 18.92 73 12598 102864 90512912
Joint swelling 58.08 18.92 3 12668 503297 90112479
Liver disorder 56.62 18.92 77 12594 121192 90494584
Alanine aminotransferase increased 56.56 18.92 76 12595 118262 90497514
Cardiac failure 53.36 18.92 71 12600 109425 90506351
Fulminant type 1 diabetes mellitus 52.44 18.92 14 12657 864 90614912
Decreased appetite 51.86 18.92 142 12529 376398 90239378
Haemorrhage subcutaneous 51.59 18.92 19 12652 3377 90612399
Iron deficiency anaemia 50.91 18.92 35 12636 23627 90592149
Upper respiratory tract inflammation 48.29 18.92 17 12654 2655 90613121
Pneumonia bacterial 45.41 18.92 26 12645 12764 90603012
Drug intolerance 45.08 18.92 5 12666 447586 90168190
Pain 44.96 18.92 44 12627 996297 89619479
Drug hypersensitivity 44.68 18.92 6 12665 463603 90152173
Enterocolitis 44.57 18.92 24 12647 10466 90605310
Febrile neutropenia 41.24 18.92 77 12594 158272 90457504
Gastric ulcer 39.74 18.92 32 12639 27416 90588360
Peritonitis 39.71 18.92 28 12643 19677 90596099
Hypokalaemia 39.57 18.92 68 12603 131048 90484728
Swelling 36.82 18.92 7 12664 419051 90196725
Gamma-glutamyltransferase increased 36.37 18.92 35 12636 37917 90577859
Calculus urinary 35.32 18.92 12 12659 1686 90614090
Glossodynia 33.94 18.92 3 12668 321776 90294000
Cerebral haemorrhage 33.39 18.92 32 12639 34490 90581286
Ileus 32.16 18.92 23 12648 16523 90599253
Pancytopenia 31.95 18.92 59 12612 120204 90495572
Cancer pain 31.57 18.92 14 12657 4011 90611765
Alopecia 31.40 18.92 15 12656 495056 90120720
Pneumocystis jirovecii pneumonia 30.86 18.92 25 12646 21591 90594185
Immune-mediated hepatic disorder 30.86 18.92 11 12660 1781 90613995
Haemoglobin decreased 30.61 18.92 69 12602 161887 90453889
Concomitant disease aggravated 29.51 18.92 19 12652 11499 90604277
Wound 28.98 18.92 4 12667 302976 90312800
Peripheral swelling 28.60 18.92 11 12660 413095 90202681
Abdominal discomfort 27.99 18.92 16 12655 477312 90138464
Blood alkaline phosphatase increased 27.86 18.92 34 12637 48045 90567731
Enteritis infectious 27.57 18.92 11 12660 2424 90613352
Gastrointestinal perforation 27.48 18.92 13 12658 4319 90611457
Duodenal ulcer haemorrhage 27.06 18.92 11 12660 2545 90613231
Colony stimulating factor therapy 26.46 18.92 7 12664 417 90615359
Compression fracture 26.30 18.92 16 12655 8773 90607003
Gastroenteritis 26.22 18.92 26 12645 29203 90586573
Herpes zoster 25.85 18.92 47 12624 94597 90521179
Gastric cancer 25.37 18.92 13 12658 5123 90610653
Thrombotic cerebral infarction 24.89 18.92 6 12665 245 90615531
Pyelonephritis acute 24.69 18.92 13 12658 5419 90610357
Anaphylactic shock 24.51 18.92 26 12645 31591 90584185
Weight increased 24.51 18.92 14 12657 417913 90197863
Pharyngitis 24.42 18.92 22 12649 21925 90593851
Depressed level of consciousness 23.61 18.92 39 12632 72745 90543031
Anxiety 23.61 18.92 7 12664 309765 90306011
Pulmonary alveolar haemorrhage 23.48 18.92 13 12658 5985 90609791
Product dose omission issue 23.33 18.92 6 12665 291681 90324095
Constipation 23.27 18.92 89 12582 280306 90335470
Colon cancer 23.09 18.92 16 12655 10928 90604848
Hepatitis fulminant 22.48 18.92 11 12660 3934 90611842
Adrenocorticotropic hormone deficiency 22.35 18.92 7 12664 761 90615015
Lymphocyte count decreased 22.31 18.92 26 12645 35024 90580752
Pneumonia aspiration 22.20 18.92 28 12643 40912 90574864
Blood urea increased 21.80 18.92 24 12647 30389 90585387
Helicobacter infection 21.67 18.92 3 12668 226847 90388929
Infusion related reaction 21.66 18.92 16 12655 416764 90199012
Systemic lupus erythematosus 21.39 18.92 12 12659 361884 90253892
Discomfort 21.27 18.92 6 12665 274329 90341447
Drug-induced liver injury 21.14 18.92 42 12629 90276 90525500
Infective spondylitis 21.11 18.92 5 12666 189 90615587
Pyelonephritis 21.07 18.92 20 12651 21296 90594480
Hypophosphataemia 20.83 18.92 17 12654 14837 90600939
Dehydration 20.68 18.92 67 12604 194380 90421396
Cutaneous symptom 20.52 18.92 6 12665 517 90615259
Breast cancer 20.46 18.92 31 12640 53730 90562046
Thyroiditis 20.30 18.92 10 12661 3627 90612149
Malignant catatonia 20.14 18.92 5 12666 231 90615545
Pulmonary toxicity 20.08 18.92 15 12656 11516 90604260
Sepsis 20.07 18.92 63 12608 179751 90436025
Subarachnoid haemorrhage 20.02 18.92 18 12653 17886 90597890
Cellulitis 19.63 18.92 41 12630 91296 90524480
Cardiac failure acute 19.62 18.92 15 12656 11914 90603862
Blood creatine phosphokinase increased 19.62 18.92 24 12647 33999 90581777
Femur fracture 19.60 18.92 28 12643 46054 90569722
Blood lactate dehydrogenase increased 19.52 18.92 21 12650 25911 90589865
Shock 19.41 18.92 22 12649 28756 90587020
Sinusitis 19.39 18.92 12 12659 343076 90272700
Hypersensitivity 19.38 18.92 21 12650 454656 90161120
Pleural effusion 19.27 18.92 46 12625 111945 90503831
Malignant pleural effusion 19.12 18.92 9 12662 2955 90612821
Sputum retention 19.09 18.92 6 12665 660 90615116

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Interstitial lung disease 286.49 18.00 205 11086 78257 42531787
Hepatic function abnormal 214.33 18.00 146 11145 51421 42558623
Platelet count decreased 92.80 18.00 146 11145 138435 42471609
Cerebral infarction 83.79 18.00 68 11223 31101 42578943
Disseminated intravascular coagulation 70.69 18.00 56 11235 24738 42585306
Malignant neoplasm progression 69.46 18.00 112 11179 108288 42501756
Fatigue 68.23 18.00 16 11275 435625 42174419
Drug eruption 67.69 18.00 53 11238 23022 42587022
Upper respiratory tract inflammation 65.48 18.00 23 11268 1873 42608171
Decreased appetite 64.03 18.00 151 11140 192986 42417058
Drug ineffective 61.02 18.00 47 11244 630150 41979894
Neutrophil count decreased 60.27 18.00 79 11212 63336 42546708
Renal impairment 50.07 18.00 98 11193 110130 42499914
Pyrexia 49.00 18.00 220 11071 393822 42216222
Toxicity to various agents 45.97 18.00 4 11287 229132 42380912
White blood cell count decreased 45.18 18.00 94 11197 110302 42499742
Non-small cell lung cancer 38.48 18.00 21 11270 4953 42605091
Drug-induced liver injury 38.40 18.00 49 11242 38224 42571820
Aspartate aminotransferase increased 36.72 18.00 70 11221 77093 42532951
Stomatitis 36.35 18.00 55 11236 50274 42559770
Pneumonia aspiration 35.14 18.00 54 11237 50024 42560020
C-reactive protein increased 33.16 18.00 60 11231 63500 42546544
Liver disorder 32.50 18.00 46 11245 39598 42570446
Gastric ulcer haemorrhage 31.87 18.00 20 11271 6107 42603937
Pneumonia 31.45 18.00 205 11086 421944 42188100
Osteonecrosis of jaw 30.35 18.00 31 11260 19018 42591026
Cholangitis 30.07 18.00 24 11267 10703 42599341
Gastric cancer 29.69 18.00 20 11271 6883 42603161
Gastric ulcer 29.61 18.00 30 11261 18232 42591812
Confusional state 28.55 18.00 5 11286 167592 42442452
Spinal compression fracture 28.23 18.00 20 11271 7463 42602581
Immune-mediated enterocolitis 28.20 18.00 18 11273 5659 42604385
Fulminant type 1 diabetes mellitus 26.86 18.00 11 11280 1363 42608681
Hyperuricaemia 26.23 18.00 21 11270 9403 42600641
Lymphangiosis carcinomatosa 26.23 18.00 10 11281 1027 42609017
Alanine aminotransferase increased 25.88 18.00 66 11225 88340 42521704
Altered state of consciousness 25.55 18.00 35 11256 29224 42580820
Blood lactate dehydrogenase increased 25.54 18.00 33 11258 26048 42583996
Cancer pain 24.69 18.00 14 11277 3553 42606491
Cardiac failure 24.55 18.00 73 11218 106783 42503261
Hypoalbuminaemia 24.14 18.00 25 11266 15585 42594459
Pneumonia bacterial 24.03 18.00 25 11266 15667 42594377
Eosinophil count increased 23.80 18.00 21 11270 10742 42599302
Product dose omission issue 23.43 18.00 6 11285 154359 42455685
Gamma-glutamyltransferase increased 22.73 18.00 35 11256 32462 42577582
Prescribed underdose 22.61 18.00 20 11271 10262 42599782
Death 21.81 18.00 59 11232 471126 42138918
Rectal cancer 21.26 18.00 11 11280 2329 42607715
Erythema multiforme 21.13 18.00 19 11272 9958 42600086
Immune-mediated hepatic disorder 20.52 18.00 11 11280 2503 42607541
Blood pressure decreased 19.67 18.00 46 11245 58286 42551758
Bulbospinal muscular atrophy congenital 19.65 18.00 4 11287 37 42610007
Gastrointestinal perforation 19.30 18.00 13 11278 4473 42605571
Radiation pneumonitis 18.93 18.00 11 11280 2922 42607122
Pneumothorax 18.82 18.00 27 11264 23516 42586528
Enteritis infectious 18.76 18.00 9 11282 1622 42608422
Hypotension 18.23 18.00 25 11266 257606 42352438
Hepatocellular carcinoma 18.14 18.00 16 11275 8178 42601866

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Interstitial lung disease 560.32 15.51 361 24105 138973 110425860
Hepatic function abnormal 504.94 15.51 288 24178 89007 110475826
Platelet count decreased 359.75 15.51 341 24125 230102 110334731
Drug eruption 188.52 15.51 128 24338 53531 110511302
Cerebral infarction 180.55 15.51 123 24343 51715 110513118
Malignant neoplasm progression 171.38 15.51 202 24264 174365 110390468
Fatigue 151.95 15.51 41 24425 1215917 109348916
White blood cell count decreased 151.08 15.51 218 24248 229172 110335661
Neutrophil count decreased 146.14 15.51 156 24310 120785 110444048
Drug ineffective 145.77 15.51 78 24388 1520462 109044371
Disseminated intravascular coagulation 134.42 15.51 94 24372 41192 110523641
Renal impairment 134.28 15.51 186 24280 188259 110376574
Pyrexia 124.52 15.51 458 24008 897807 109667026
Spinal compression fracture 116.50 15.51 64 24402 18328 110546505
Osteonecrosis of jaw 110.93 15.51 89 24377 47928 110516905
Upper respiratory tract inflammation 109.90 15.51 40 24426 4331 110560502
Decreased appetite 109.84 15.51 290 24176 475556 110089277
Anaemia 96.77 15.51 303 24163 546783 110018050
Gastric ulcer haemorrhage 92.42 15.51 45 24421 10049 110554784
Altered state of consciousness 89.12 15.51 85 24381 57541 110507292
Aspartate aminotransferase increased 88.17 15.51 140 24326 159796 110405037
Erythema multiforme 82.93 15.51 54 24412 21043 110543790
Confusional state 78.01 15.51 7 24459 468673 110096160
Drug hypersensitivity 74.99 15.51 7 24459 454083 110110750
Liver disorder 74.95 15.51 122 24344 142121 110422712
Blood bilirubin increased 72.94 15.51 87 24379 75885 110488948
Joint swelling 72.67 15.51 7 24459 442838 110121995
Cardiac failure 71.91 15.51 140 24326 187486 110377347
Alanine aminotransferase increased 71.50 15.51 138 24328 183635 110381198
Blood pressure decreased 70.78 15.51 106 24360 114985 110449848
Pneumonia bacterial 65.64 15.51 51 24415 26210 110538623
Pain 65.47 15.51 69 24397 954886 109609947
Drug intolerance 65.20 15.51 7 24459 406505 110158328
Fulminant type 1 diabetes mellitus 64.57 15.51 23 24443 2340 110562493
Gastric ulcer 63.97 15.51 60 24406 39767 110525066
Toxicity to various agents 62.11 15.51 15 24451 480540 110084293
Pneumonia aspiration 60.53 15.51 82 24384 81151 110483682
Milk-alkali syndrome 60.46 15.51 21 24445 1984 110562849
Gamma-glutamyltransferase increased 58.51 15.51 70 24396 61239 110503594
Cancer pain 58.44 15.51 29 24437 6743 110558090
Haemorrhage subcutaneous 57.74 15.51 27 24439 5512 110559321
Non-small cell lung cancer 54.10 15.51 29 24437 7906 110556927
Enterocolitis 52.20 15.51 39 24427 18910 110545923
Peritonitis 52.13 15.51 49 24417 32558 110532275
Peripheral swelling 51.44 15.51 13 24453 404021 110160812
Gastric cancer 50.31 15.51 31 24435 10977 110553856
Pneumonia 49.88 15.51 348 24118 876366 109688467
Anxiety 48.19 15.51 9 24457 345069 110219764
Blood lactate dehydrogenase increased 47.96 15.51 54 24412 44280 110520553
Immune-mediated hepatic disorder 47.34 15.51 22 24444 4428 110560405
Swelling 47.26 15.51 10 24456 351031 110213802
Iron deficiency anaemia 45.86 15.51 45 24421 31514 110533319
Cholangitis 45.85 15.51 34 24432 16301 110548532
Drug-induced liver injury 45.26 15.51 89 24377 119978 110444855
Hyperuricaemia 44.77 15.51 32 24434 14499 110550334
Gastrointestinal perforation 44.62 15.51 25 24441 7431 110557402
Therapeutic product effect decreased 42.43 15.51 3 24463 244313 110320520
Constipation 42.39 15.51 174 24292 357612 110207221
Enteritis infectious 40.70 15.51 19 24447 3863 110560970
Cerebral haemorrhage 40.16 15.51 60 24406 64908 110499925
Hypoalbuminaemia 39.67 15.51 40 24426 28934 110535899
Herpes zoster 39.24 15.51 79 24387 108300 110456533
Colon cancer 39.07 15.51 31 24435 16412 110548421
Haemoglobin decreased 38.65 15.51 132 24334 248595 110316238
Product dose omission issue 37.90 15.51 12 24454 321770 110243063
Pneumocystis jirovecii pneumonia 37.86 15.51 47 24419 42688 110522145
Glossodynia 37.77 15.51 3 24463 222001 110342832
Compression fracture 37.03 15.51 24 24442 9275 110555558
Pneumothorax 36.51 15.51 42 24424 35243 110529590
Blood alkaline phosphatase increased 36.20 15.51 60 24406 70875 110493958
Pleural effusion 33.69 15.51 101 24365 177608 110387225
Febrile neutropenia 33.60 15.51 149 24317 316618 110248215
Physical deconditioning 33.07 15.51 16 24450 3521 110561312
Alopecia 32.87 15.51 20 24446 364733 110200100
Infusion related reaction 32.85 15.51 22 24444 381140 110183693
Shock haemorrhagic 32.61 15.51 35 24431 27212 110537621
Weight increased 32.58 15.51 27 24439 419617 110145216
Calculus urinary 31.73 15.51 15 24451 3137 110561696
Pharyngitis 31.38 15.51 33 24433 25065 110539768
Hypersensitivity 31.36 15.51 26 24440 403972 110160861
Paraesthesia 31.35 15.51 11 24455 276510 110288323
Blood creatine phosphokinase increased 31.03 15.51 57 24409 73020 110491813
Wound 30.89 15.51 7 24459 234430 110330403
Cardiac failure acute 30.72 15.51 32 24434 24046 110540787
Immune-mediated enterocolitis 30.39 15.51 22 24444 10163 110554670
Adrenocorticotropic hormone deficiency 30.30 15.51 13 24453 2169 110562664
Lymphocyte count decreased 29.99 15.51 49 24417 57194 110507639
Pericarditis 29.98 15.51 6 24460 219108 110345725
General physical health deterioration 29.88 15.51 30 24436 425265 110139568
Product use in unapproved indication 29.82 15.51 33 24433 447344 110117489
Hypopituitarism 29.81 15.51 16 24450 4374 110560459
Hypotension 29.39 15.51 44 24422 523805 110041028
Cerebrovascular accident 29.36 15.51 3 24463 181281 110383552
Radiation pneumonitis 29.31 15.51 16 24450 4520 110560313
Thyroiditis 28.75 15.51 18 24448 6555 110558278
Lymphangiosis carcinomatosa 28.69 15.51 13 24453 2469 110562364
Completed suicide 28.60 15.51 9 24457 242372 110322461
Sleep disorder 28.11 15.51 5 24461 198639 110366194
Asthenia 28.09 15.51 70 24396 688929 109875904
Duodenal ulcer haemorrhage 27.79 15.51 19 24447 8018 110556815
Mobility decreased 27.69 15.51 9 24457 237413 110327420
Hypokalaemia 27.60 15.51 96 24370 182352 110382481
Small intestinal perforation 27.08 15.51 15 24451 4361 110560472
Eosinophil count increased 26.89 15.51 28 24438 21030 110543803
Chronic gastritis 26.69 15.51 16 24450 5395 110559438
Thrombotic cerebral infarction 26.61 15.51 9 24457 785 110564048
Cytomegalovirus enterocolitis 26.53 15.51 12 24454 2269 110562564
Abdominal discomfort 26.30 15.51 29 24437 393829 110171004
Shunt occlusion 26.28 15.51 11 24455 1726 110563107
Dyspnoea 26.27 15.51 141 24325 1106731 109458102
Type 2 diabetes mellitus 26.10 15.51 4 24462 177228 110387605
Blood urea increased 26.07 15.51 45 24421 54912 110509921
Small intestine ulcer 25.79 15.51 9 24457 862 110563971
Infective spondylitis 25.78 15.51 8 24458 530 110564303
Memory impairment 25.70 15.51 6 24460 196938 110367895
Psoriatic arthropathy 25.67 15.51 6 24460 196755 110368078
Cholecystitis 25.42 15.51 30 24436 25852 110538981
Discomfort 25.28 15.51 8 24458 214699 110350134
Pulmonary toxicity 25.22 15.51 25 24441 17721 110547112
Post herpetic neuralgia 25.16 15.51 13 24453 3288 110561545
Shunt stenosis 24.95 15.51 10 24456 1406 110563427
Pancytopenia 24.84 15.51 102 24364 209511 110355322
Tumour haemorrhage 24.55 15.51 15 24451 5230 110559603
Hepatitis fulminant 24.43 15.51 18 24448 8542 110556291
Wheezing 24.41 15.51 13 24453 255217 110309616
Sinusitis 24.40 15.51 18 24448 296670 110268163
Ileus 24.38 15.51 32 24434 30697 110534136
Dry mouth 24.36 15.51 7 24459 199941 110364892
Ureterolithiasis 24.30 15.51 14 24452 4388 110560445
Cellulitis 24.23 15.51 72 24394 125944 110438889
Folliculitis 24.21 15.51 4 24462 167649 110397184
Muscle spasms 24.03 15.51 16 24450 278141 110286692
Concomitant disease aggravated 23.15 15.51 23 24443 16341 110548492
Subdural haematoma 23.00 15.51 34 24432 36420 110528413
Maternal exposure during pregnancy 22.92 15.51 14 24452 254869 110309964
Hypocalcaemia 22.88 15.51 47 24419 65319 110499514
Aortic dissection 22.82 15.51 14 24452 4919 110559914
Hypothyroidism 22.73 15.51 50 24416 72849 110491984
C-reactive protein increased 22.71 15.51 102 24364 217817 110347016
Lymphoma 22.55 15.51 25 24441 20146 110544687
Pyelonephritis acute 22.48 15.51 16 24450 7197 110557636
Cerebellar haemorrhage 22.43 15.51 12 24454 3259 110561574
Metastases to liver 22.32 15.51 33 24433 35353 110529480
Diabetes mellitus 22.25 15.51 60 24406 99321 110465512
Therapy non-responder 22.17 15.51 4 24462 157303 110407530
Hepatocellular carcinoma 22.14 15.51 18 24448 9862 110554971
Cholecystitis acute 21.99 15.51 22 24444 15760 110549073
Weight decreased 21.96 15.51 44 24422 468013 110096820
Sputum retention 21.89 15.51 9 24457 1350 110563483
Femur fracture 21.87 15.51 37 24429 44432 110520401
Thalamus haemorrhage 21.80 15.51 10 24456 1954 110562879
Immune-mediated myocarditis 21.67 15.51 12 24454 3486 110561347
Dyslalia 21.65 15.51 9 24457 1388 110563445
Systemic lupus erythematosus 21.47 15.51 15 24451 254323 110310510
Irritable bowel syndrome 21.43 15.51 5 24461 164210 110400623
Off label use 21.28 15.51 221 24245 1499964 109064869
Helicobacter infection 21.02 15.51 7 24459 181870 110382963
Conjunctival hyperaemia 20.68 15.51 14 24452 5817 110559016
Cardiac failure chronic 20.64 15.51 20 24446 13791 110551042
Musculoskeletal stiffness 20.50 15.51 19 24447 279803 110285030
Colony stimulating factor therapy 20.43 15.51 7 24459 635 110564198
Infectious pleural effusion 20.40 15.51 13 24453 4878 110559955
Impaired healing 20.36 15.51 9 24457 196708 110368125
Renal disorder 20.26 15.51 38 24428 49441 110515392
Idiopathic pulmonary fibrosis 20.13 15.51 13 24453 4991 110559842
Night sweats 19.78 15.51 3 24463 133980 110430853
Ascites 19.75 15.51 55 24411 92753 110472080
Periodontitis 19.66 15.51 13 24453 5195 110559638
Enterocolitis bacterial 19.54 15.51 7 24459 724 110564109
Immune-mediated lung disease 19.44 15.51 13 24453 5290 110559543
Blood creatinine increased 19.35 15.51 86 24380 182803 110382030
Brain stem haemorrhage 19.34 15.51 9 24457 1817 110563016
Toxic skin eruption 19.32 15.51 27 24439 27488 110537345
White blood cell count increased 19.25 15.51 56 24410 96786 110468047
Contraindicated product administered 19.22 15.51 16 24450 248251 110316582
Bursitis 18.98 15.51 3 24463 129915 110434918
Cholangitis acute 18.94 15.51 9 24457 1904 110562929
Dehydration 18.87 15.51 116 24350 279395 110285438
Death 18.86 15.51 85 24381 698784 109866049
Gastroenteritis 18.70 15.51 32 24434 38768 110526065
Hyperglycaemia 18.68 15.51 51 24415 85039 110479794
Duodenal perforation 18.54 15.51 10 24456 2760 110562073
Fracture 18.42 15.51 25 24441 24763 110540070
Femoral neck fracture 18.41 15.51 18 24448 12549 110552284
Paronychia 18.38 15.51 17 24449 11064 110553769
Corneal erosion 18.33 15.51 6 24460 473 110564360
Cutaneous symptom 18.23 15.51 7 24459 878 110563955
Immune-mediated hypothyroidism 18.19 15.51 10 24456 2865 110561968
Rectal cancer 18.16 15.51 11 24455 3778 110561055
Arthralgia 18.08 15.51 100 24366 779532 109785301
Pyelonephritis 18.06 15.51 25 24441 25225 110539608
Anaphylactic shock 17.97 15.51 37 24429 51509 110513324
Melaena 17.96 15.51 44 24422 68713 110496120
Intentional product use issue 17.96 15.51 17 24449 247889 110316944
Ocular dysmetria 17.85 15.51 4 24462 73 110564760
Depressed level of consciousness 17.78 15.51 60 24406 112218 110452615
Faeces discoloured 17.70 15.51 29 24437 33919 110530914
Product use issue 17.64 15.51 26 24440 311669 110253164
Pulmonary alveolar haemorrhage 17.58 15.51 22 24444 20128 110544705
Malaise 17.47 15.51 226 24240 671593 109893240
Malignant pleural effusion 17.38 15.51 11 24455 4082 110560751
Immune thrombocytopenia 17.19 15.51 23 24443 22471 110542362
Liver injury 17.01 15.51 6 24460 150407 110414426
Rectal haemorrhage 16.99 15.51 3 24463 119830 110445003
Shock 16.98 15.51 37 24429 53551 110511282
Exposure during pregnancy 16.80 15.51 8 24458 167416 110397417
Adrenal insufficiency 16.66 15.51 32 24434 42358 110522475
Gastric polyps 16.64 15.51 12 24454 5511 110559322
Depression 16.50 15.51 28 24438 317307 110247526
Silent thyroiditis 16.44 15.51 5 24461 310 110564523
Tumour associated fever 16.39 15.51 7 24459 1154 110563679
Osteomyelitis 16.10 15.51 29 24437 36571 110528262
Skin erosion 16.01 15.51 12 24454 5842 110558991
Blister 16 15.51 16 24450 227360 110337473
Hypoproteinaemia 15.85 15.51 12 24454 5933 110558900
Large intestine polyp 15.64 15.51 18 24448 15099 110549734
Injury 15.57 15.51 10 24456 177255 110387578
Hypophosphataemia 15.51 15.51 27 24439 33155 110531678

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A02BX14 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR ACID RELATED DISORDERS
DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
Other drugs for peptic ulcer and gastro-oesophageal reflux disease (GORD)
MeSH PA D000897 Anti-Ulcer Agents
MeSH PA D000975 Antioxidants
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D005765 Gastrointestinal Agents
MeSH PA D020011 Protective Agents
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35842 antirheumatic drug
CHEBI has role CHEBI:48578 radical scavenger
CHEBI has role CHEBI:49201 anti-ulcer drug
CHEBI has role CHEBI:55324 gastrointestinal drug
CHEBI has role CHEBI:66981 ophthalmology drug
CHEBI has role CHEBI:67079 anti-inflammatory agent

Related Drugs by ATC class:

A02BX Other drugs for peptic ulcer and gastro-oesophageal reflux disease (GORD) 15 drugs
acetoxolonealginic acidbismuth subcitratebismuth subnitratecarbenoxolonegefarnateirsogladinemethiosulfonium chloridepirenzepineproglumidesucralfatesulglicotide show all 15 →

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Gastritis indication 4556007 DOID:4029
Peptic ulcer indication 13200003 DOID:750




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.32 acidic
pKa2 12.06 acidic
pKa3 13.42 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Cholecystokinin receptor type A GPCR AGONIST IC50 4.40 IUPHAR

External reference:

IDSource
D01121 KEGG_DRUG
C0069562 UMLSCUI
CHEBI:32090 CHEBI
VJX PDB_CHEM_ID
CHEMBL1697771 ChEMBL_ID
DB11656 DRUGBANK_ID
C052785 MESH_SUPPLEMENTAL_RECORD_UI
5042 PUBCHEM_CID
871 IUPHAR_LIGAND_ID
6454 INN_ID
LR583V32ZR UNII
1172393005 SNOMEDCT_US
1172878003 SNOMEDCT_US

Pharmaceutical products:

None