acetoxolone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
steroids not used as glucocorticosteroids 62 6277-14-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • acetoxolone
  • acetylglycyrrhetic acid
  • acetylglycyrrhetinic acid
  • glycyrrhetic acid acetate
  • glycyrrhetinic acid acetate
  • glycyrrhetinyl acetate
  • Molecular weight: 512.73
  • Formula: C32H48O5
  • CLOGP: 7.42
  • LIPINSKI: 2
  • HAC: 5
  • HDO: 1
  • TPSA: 80.67
  • ALOGS: -5.97
  • ROTB: 3

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A02BX09 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR ACID RELATED DISORDERS
DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
Other drugs for peptic ulcer and gastro-oesophageal reflux disease (GORD)

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Gastritis indication 4556007 DOID:4029




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.89 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Liver carboxylesterase 1 Enzyme IC50 4.30 CHEMBL
Estradiol 17-beta-dehydrogenase 1 Enzyme IC50 4.73 CHEMBL
Estradiol 17-beta-dehydrogenase 2 Enzyme IC50 5.42 CHEMBL
Corticosteroid 11-beta-dehydrogenase isozyme 2 Enzyme IC50 6.70 CHEMBL
Corticosteroid 11-beta-dehydrogenase isozyme 1 Enzyme IC50 6.10 CHEMBL
Cocaine esterase Enzyme IC50 4.39 CHEMBL

External reference:

IDSource
16784 RXNORM
C0050521 UMLSCUI
CHEBI:81306 CHEBI
CHEMBL207413 ChEMBL_ID
DB13640 DRUGBANK_ID
C013384 MESH_SUPPLEMENTAL_RECORD_UI
CWW961Q19K UNII
94320 PUBCHEM_CID
004300 NDDF

Pharmaceutical products:

None